Science.gov

Sample records for administration central heating

  1. Centralized administrative services management.

    PubMed

    Freed, D H

    1994-06-01

    Virtually every hospital has imposed guidelines or controls on one or more administrative service expenses. However, the actual deployment of such strategies is often voluntary, decentralized, disjointed and episodic. An alternative approach is to cluster administrative elements across hospital departments and make them the responsibility of a dedicated manager. This approach treats administrative services as an organizing principle with uniform, predictable standards of service and cost. Customer requirements for products and services are met without the need for them to physically manage that process. Materiel managers can demonstrate a leadership role by applying their professionalism and know-how to a set of products and services traditionally ignored or dealt with in an uncoordinated manner. While some initial resistance can be expected as traditional barriers are disassembled, the results should be very rewarding for the hospital and materiel manager alike.

  2. 8. PHOTOCOPY, HEATING DRAWING FOR ADMINISTRATION BUILDING. NIKE Missile ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. PHOTOCOPY, HEATING DRAWING FOR ADMINISTRATION BUILDING. - NIKE Missile Base SL-40, Administration Building, East central portion of base, southeast of Mess Hall, northeast of HIPAR Equipment Building, Hecker, Monroe County, IL

  3. Voices from the Field: Central Office Administrators

    ERIC Educational Resources Information Center

    Dickson, Ken

    2015-01-01

    School systems' central office administrators sometimes take paths that seem easiest, even when it is clear the paths will not lead to sustained positive results that are needed--particularly in terms of twice-exceptional (2e) students. To appropriately address the needs of 2e learners, we must ensure that central office administrative services…

  4. The Physics of Central Heating of Houses

    ERIC Educational Resources Information Center

    Cowking, A.; And Others

    1978-01-01

    Explains the function of a central heating system and calculates the total heat energy required to heat a house. Estimates annual heat requirement and amount of fuel needed. Gives detailed calculation of heat required for a particular house as an example. (G A)

  5. 47 CFR 52.15 - Central office code administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Central office code administration. 52.15... (CONTINUED) NUMBERING Administration § 52.15 Central office code administration. (a) Central Office Code.... (b) Duties of the entity or entities performing central office code administration may include,...

  6. German central solar heating plants with seasonal heat storage

    SciTech Connect

    Bauer, D.; Marx, R.; Nussbicker-Lux, J.; Ochs, F.; Heidemann, W.; Mueller-Steinhagen, H.

    2010-04-15

    Central solar heating plants contribute to the reduction of CO{sub 2}-emissions and global warming. The combination of central solar heating plants with seasonal heat storage enables high solar fractions of 50% and more. Several pilot central solar heating plants with seasonal heat storage (CSHPSS) built in Germany since 1996 have proven the appropriate operation of these systems and confirmed the high solar fractions. Four different types of seasonal thermal energy stores have been developed, tested and monitored under realistic operation conditions: Hot-water thermal energy store (e.g. in Friedrichshafen), gravel-water thermal energy store (e.g. in Steinfurt-Borghorst), borehole thermal energy store (in Neckarsulm) and aquifer thermal energy store (in Rostock). In this paper, measured heat balances of several German CSHPSS are presented. The different types of thermal energy stores and the affiliated central solar heating plants and district heating systems are described. Their operational characteristics are compared using measured data gained from an extensive monitoring program. Thus long-term operational experiences such as the influence of net return temperatures are shown. (author)

  7. 1. EXTERIOR OF CENTRAL HEATING STATION, BUILDING 102, LOOKING NORTH. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EXTERIOR OF CENTRAL HEATING STATION, BUILDING 102, LOOKING NORTH. - Mill Valley Air Force Station, Central Heating Station, East Ridgecrest Boulevard, Mount Tamalpais, Mill Valley, Marin County, CA

  8. Heat Exchange After Atropine and Pralidoxime Administration

    DTIC Science & Technology

    1986-12-01

    calculated from weight changes. b,,Z&-expected result -of 4 tropine injection, decreased eccrine sweating 6-66%v po<.05) and elevated esophageal W-O- ’ and...The expected result of atropine injection, decreased eccrine sweating (-60%, pɘ.05) and elevated esophageal (+0.4 0C, pɘ.05) and skin temperatures...heat, pralidoxime chloride, sweating rate vii r-1 INTRODUCTION Eccrine sweat gland activity is depressed by systemic or local atropine administration

  9. 7 CFR 3.43 - Non-centralized administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Non-centralized administrative offset. 3.43 Section 3.43 Agriculture Office of the Secretary of Agriculture DEBT MANAGEMENT Administrative Offset § 3.43 Non-centralized administrative offset. (a) Scope. In cooperation with the Federal agency certifying...

  10. 3. INTERIOR VIEW OF CENTRAL HEATING STATION, BUILDING 102, SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. INTERIOR VIEW OF CENTRAL HEATING STATION, BUILDING 102, SHOWING FURNACES, LOOKING SOUTH. - Mill Valley Air Force Station, Central Heating Station, East Ridgecrest Boulevard, Mount Tamalpais, Mill Valley, Marin County, CA

  11. Developing a Performance Measurement System for University Central Administrative Services

    ERIC Educational Resources Information Center

    Arena, Marika; Arnaboldi, Michela; Azzone, Giovanni; Carlucci, Paola

    2009-01-01

    Central administrative services have recently received increasing attention from practitioners and academics due to the challenging need to both manage scarce resources and provide high-quality services. In this context, performance measurement systems (PMSs) may assume a central role, although an unresolved debate remains on the claimed benefits…

  12. Central solar heating plants with seasonal storage

    SciTech Connect

    Breger, D.S.; Sunderland, J.E.

    1989-03-01

    The University of Massachusetts has recently started a two year effort to identify and design a significant Central Solar Heating Plant with Seasonal Storage (CSHPSS) in Massachusetts. The work is closely associated with the U.S. participation in the International Energy Agency (IEA) Task on CSHPSS. The University is working closely with the Commonwealth of Massachusetts to assist in identifying State facilities as potential sites and to explore and secure State support which will be essential for product development after the design phase. Currently, the primary site is the University of Massachusetts, Amherst campus with particular interest in several large buildings which are funded for construction over the next 4-5 years. Seasonal thermal energy storage will utilize one of several geological formations.

  13. Intraventricular administration of isoproterenol inhibits both heat production and heat loss mechanisms in rats.

    PubMed

    Lin, M T; Chandra, A; Fan, Y C; Sun, R

    1980-07-15

    At an ambient temperature (Ta) of 8 degrees C, intraventricular administration of isoproterenol inhibited metabolic heat production and led to hypothermia in rats. In contrast, at a Ta of 22 degrees C and of 30 degrees C, isoproterenol decreased cutaneous circulation and led to hyperthermia. The data indicate that isoproterenol inhibits both heat production and heat loss mechanisms in rats.

  14. Central nervous system administration of interleukin-6 produces splenic sympathoexcitation

    PubMed Central

    Helwig, Bryan G.; Craig, Robin A.; Fels, Richard J.; Blecha, Frank; Kenney, Michael J.

    2008-01-01

    Interleukin-6 (IL-6) is a multifunctional cytokine that has been shown to play a pivotal role in centrally-mediated physiological responses including activation of the hypothalamic-pituitary-adrenal axis. Cerebral spinal fluid (CSF) concentrations of IL-6 are elevated in multiple pathophysiological conditions including Alzheimer’s disease, autoimmune disease, and meningitis. Despite this, the effect of IL-6 on central regulation of sympathetic nerve discharge (SND) remains unknown which limits understanding of sympathetic-immune interactions in health and disease. In the present study we determined the effect of intracerebroventricular (icv, lateral ventricle) administration of IL-6 on splenic SND in urethane-chloralose-anesthetized rats. A second goal was to determine if icv injected IL-6 enters the brain parenchyma and acts as a volume transmission signal to access areas of the brain involved in regulation of sympathetic nerve outflow. Icv administration of IL-6 (10 ng, 100 ng, and 400 ng) significantly and progressively increased splenic SND from control levels in baroreceptor denervated Sprague-Dawley rats. Administration of 100 ng and 400 ng IL-6 resulted in significantly higher SND responses when compared to those elicited with a 10 ng dose. Sixty minutes following icv administration, fluorescently labeled IL-6 was not distributed throughout the parenchyma of the brain but was localized to the periventricular areas of the ventricular system. Brain sections counter-stained for the IL-6 receptor (IL-6R) revealed that IL-6 and the IL-6R were co-localized in periventricular areas adjoining the third ventricle. These results demonstrate that icv IL-6 administration increases splenic SND, an effect likely achieved via signaling mechanisms originating in the periventricular cells. PMID:18547874

  15. Indoor air pollution by different heating systems: coal burning, open fireplace and central heating.

    PubMed

    Moriske, H J; Drews, M; Ebert, G; Menk, G; Scheller, C; Schöndube, M; Konieczny, L

    1996-11-01

    Investigations of indoor air pollution by different heating systems in private homes are described. Sixteen homes, 7 with coal burning, 1 with open fireplace (wood burning) and 8 with central heating have been investigated. We measured the concentrations of carbon monoxide, carbon dioxide and sedimented dust in indoor air, of total suspended particulates, heavy metals and of polycyclic aromatic hydrocarbons in indoor and outdoor air. Measurements were taken during winter (heating period) and during summer (non-heating period). Generally, we found higher indoor air pollution in homes with coal burning and open fireplace than in homes with central heating. Especially, the concentrations of carbon monoxide, sedimented dust and of some heavy metals were higher. In one case, we found also high indoor air pollution in a home with central heating. This apartment is on the ground floor of a block of flats, and the central heating system in the basement showed a malfunctioning of the exhaust system.

  16. Investigating the efficiency of development of centralized heating in Russia

    NASA Astrophysics Data System (ADS)

    Volkova, E. A.; Makarova, A. S.; Khorshev, A. A.; Urvantseva, L. V.; Shul'Gina, V. S.

    2010-12-01

    The efficiency of centralized heating systems developed on a local level in Russia has been studied. The obtained results allow numerous schemes applied for the heat and electricity supply used in various towns to be generalized and a unified system of technical and economic indices to be formulated that characterize the technology of heat and power generation and transport. Using these indices, calculations of the efficiency of combined and separate schemes of energy supply in various climatic zones of Russia have been performed. Based on the complex comparative analysis of the efficiency of centralized heating systems with allowance for the local and system factors, it is possible to estimate the optimum scale of centralized heating in Russia up to 2030 and recognize the main trends in the development of this industry in various stages of its development.

  17. Expedient arrangement of newly constructed systems for centralized heat supply

    NASA Astrophysics Data System (ADS)

    Zeigarnik, Yu. A.; Rotinov, A. G.

    2008-11-01

    It is shown that for newly constructed combined-cycle cogeneration plants and nuclear cogeneration plants, the optimum arrangement of the centralized heat supply system is the combination of a cogeneration plant and a district heat-supply station (a boiler house).

  18. OVERVIEW OF CENTRAL HEATING PLANT, WITH OIL STORAGE ON LEFT, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    OVERVIEW OF CENTRAL HEATING PLANT, WITH OIL STORAGE ON LEFT, BOILER BUILDING ON RIGHT, SOUTH AND EAST ELEVATIONS, CAMERA FACING NORTH. - New Haven Rail Yard, Central Steam Plant and Oil Storage, Vicinity of Union Avenue, New Haven, New Haven County, CT

  19. Selection Guidelines for Central Heat Plant Controls.

    DTIC Science & Technology

    1994-11-01

    with information essential for improving future reports. 1. Does this report satisfy a need? (Comment on purpose, related project, or other area of... satisfy the heating needs by generating and distributing steam in a safe, reliable and cost-effective manner (Wohadlo et al., 1990). The heart of the... HOTE : IF FLUE DUST & ASH 100 - % COMB. IN REFUSE SAMPLE PIT REFUSE DIFFER MATERIALLY 24 -- IN COMBUSTIBLE CONTENT, THEY ITEM 43 ITEM 22 ITEM 23 SHOULD

  20. The Black-White Achievement Gap through the Lens of Central Office Administrators

    ERIC Educational Resources Information Center

    Baskin, Roger S., Sr.

    2013-01-01

    This study investigated the perceptions of Black and White central office administrators regarding the Black-White achievement gap. Four research questions (RQ) were explored: RQ1: How do central office administrators understand the causes of the Black-White achievement gap? RQ2: How do central office administrators perceive their role in…

  1. Changes in the timing, length and heating degree days of the heating season in central heating zone of China

    NASA Astrophysics Data System (ADS)

    Shen, Xiangjin; Liu, Binhui

    2016-09-01

    Climate change affects the demand for energy consumption, especially for heating and cooling buildings. Using daily mean temperature (Tmean) data, this study analyzed the spatiotemporal changes of the starting date for heating (HS), ending date for heating (HE), length (HL) and heating degree day (HDD) of the heating season in central heating zone of China. Over China’s central heating zone, regional average HS has become later by 0.97 day per decade and HE has become earlier by 1.49 days per decade during 1960–2011, resulting in a decline of HL (‑2.47 days/decade). Regional averaged HDD decreased significantly by 63.22 °C/decade, which implies a decreasing energy demand for heating over the central heating zone of China. Spatially, there are generally larger energy-saving rate in the south, due to low average HDD during the heating season. Over China’s central heating zone, Tmean had a greater effect on HL in warm localities and a greater effect on HDD in cold localities. We project that the sensitivity of HL (HDD) to temperature change will increase (decrease) in a warmer climate. These opposite sensitivities should be considered when we want to predict the effects of climate change on heating energy consumption in China in the future.

  2. Changes in the timing, length and heating degree days of the heating season in central heating zone of China

    PubMed Central

    Shen, Xiangjin; Liu, Binhui

    2016-01-01

    Climate change affects the demand for energy consumption, especially for heating and cooling buildings. Using daily mean temperature (Tmean) data, this study analyzed the spatiotemporal changes of the starting date for heating (HS), ending date for heating (HE), length (HL) and heating degree day (HDD) of the heating season in central heating zone of China. Over China’s central heating zone, regional average HS has become later by 0.97 day per decade and HE has become earlier by 1.49 days per decade during 1960–2011, resulting in a decline of HL (−2.47 days/decade). Regional averaged HDD decreased significantly by 63.22 °C/decade, which implies a decreasing energy demand for heating over the central heating zone of China. Spatially, there are generally larger energy-saving rate in the south, due to low average HDD during the heating season. Over China’s central heating zone, Tmean had a greater effect on HL in warm localities and a greater effect on HDD in cold localities. We project that the sensitivity of HL (HDD) to temperature change will increase (decrease) in a warmer climate. These opposite sensitivities should be considered when we want to predict the effects of climate change on heating energy consumption in China in the future. PMID:27651063

  3. Changes in the timing, length and heating degree days of the heating season in central heating zone of China.

    PubMed

    Shen, Xiangjin; Liu, Binhui

    2016-09-21

    Climate change affects the demand for energy consumption, especially for heating and cooling buildings. Using daily mean temperature (Tmean) data, this study analyzed the spatiotemporal changes of the starting date for heating (HS), ending date for heating (HE), length (HL) and heating degree day (HDD) of the heating season in central heating zone of China. Over China's central heating zone, regional average HS has become later by 0.97 day per decade and HE has become earlier by 1.49 days per decade during 1960-2011, resulting in a decline of HL (-2.47 days/decade). Regional averaged HDD decreased significantly by 63.22 °C/decade, which implies a decreasing energy demand for heating over the central heating zone of China. Spatially, there are generally larger energy-saving rate in the south, due to low average HDD during the heating season. Over China's central heating zone, Tmean had a greater effect on HL in warm localities and a greater effect on HDD in cold localities. We project that the sensitivity of HL (HDD) to temperature change will increase (decrease) in a warmer climate. These opposite sensitivities should be considered when we want to predict the effects of climate change on heating energy consumption in China in the future.

  4. 9. Print of a drawing: "Proposed Central Heating Plant. Quartermaster ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Print of a drawing: "Proposed Central Heating Plant. Quartermaster Area. Fort Benjamin Harrison. Indiana." 7S1, Plan No. 1, dated January 8, 1920. (8" x 10? print enlarged from 4" x 5" negative.) - Fort Benjamin Harrison, Building No. 27, Otis Avenue east of Green Avenue, Lawrence, Marion County, IN

  5. Deska: Tool for Central Administration of a Grid Site

    NASA Astrophysics Data System (ADS)

    Kundrát, Jan; Krejčová, Martina; Hubík, Tomáš; Kerpl, Lukáš

    2011-12-01

    Running a typical Tier-2 site requires mastering quite a few tools for fabric management. Keeping an inventory of installed HW machines, their roles and detailed information, from IP addresses to rack locations, is typically done using various in-house applications ranging from simple spreadsheets to web applications. Such solutions, whose documentation usually leaves much to be desired, typically do not prevent a significant duplication of information, and therefore the data therein quickly become obsolete. After having deployed Cfengine as one of a few sites in the WLCG environment, the Prague Tier-2 site set forth to further automate the fabric management, developing the Deska project. The aim of the system is to provide a central place to perform changes, from adding new machines or moving them between racks to changing their assigned service roles and additional metadata. The database provides an authoritative source of information from which all other systems and services (like DHCP servers, Ethernet switches or the Cfengine system) pull their data, using newly developed configuration adaptors. An easy-to-use command line interface modelled after the Cisco IOS-based switches was developed, enabling the data center administrators to easily change any information in an intuitive way. We provide an overview of the current status of the implementation and describe our design choices aimed at further reducing the system engineers' workload.

  6. Nonadiabatic heating of the central plasma sheet at substorm onset

    NASA Technical Reports Server (NTRS)

    Huang, C. Y.; Frank, L. A.; Rostoker, G.; Fennell, J.; Mitchell, D. G.

    1992-01-01

    Heating events in the plasma sheet boundary layer and central plasma sheet are found to occur at the onset of expansive phase activity. The main effect is a dramatic increase in plasma temperature, coincident with a partial dipolarization of the magnetic field. Fluxes of energetic particles increase without dispersion during these events which occur at all radial distances up to 23 RE, the apogee of the ISEE spacecraft. A major difference between these heating events and those observed at geosynchronous distances lies in the heating mechanism which is nonadiabatic beyond 10 RE but may be adiabatic closer to earth. The energy required to account for the increase in plasma thermal energy is comparable with that required for Joule heating of the ionosphere. The plasma sheet must be considered as a major sink in the energy balance of a substorm. Lobe magnetic pressures during these events are estimated. Change in lobe pressure are generally not correlated with onsets or intensifications of expansive phase activity.

  7. Can intradermal administration of angiotensin II influence human heat loss responses during whole body heat stress?

    PubMed

    Fujii, Naoto; Meade, Robert D; Paull, Gabrielle; McGinn, Ryan; Foudil-bey, Imane; Akbari, Pegah; Kenny, Glen P

    2015-05-01

    It is unclear if angiotensin II, which can increase the production of reactive oxygen species (oxidative stress), modulates heat loss responses of cutaneous blood flow and sweating. We tested the hypothesis that angiotensin II-induced increases in oxidative stress impair cutaneous perfusion and sweating during rest and exercise in the heat. Eleven young (24 ± 4 yr) healthy adults performed two 30-min cycling bouts at a fixed rate of metabolic heat production (400 W) in the heat (35°C). The first and second exercises were followed by a 20- and 40-min recovery. Four microdialysis fibers were placed in the forearm skin for continuous administration of either: 1) lactated Ringer (control), 2) 10 μM angiotensin II, 3) 10 mM ascorbate (an antioxidant), or 4) a combination of 10 μM angiotensin II + 10 mM ascorbate. Cutaneous vascular conductance (CVC; laser-Doppler perfusion units/mean arterial pressure) and sweating (ventilated capsule) were evaluated at each skin site. Compared with control, angiotensin II reduced both CVC and sweating at baseline resting and during each recovery in the heat (all P < 0.05). However, during both exercise bouts, there were no differences in CVC or sweating between the treatment sites (all P > 0.05). When ascorbate was coinfused with angiotensin II, the effect of angiotensin II on sweating was abolished (all P > 0.05); however, its effect on CVC at baseline resting and during each recovery remained intact (all P < 0.05). We show angiotensin II impairs cutaneous perfusion independent of oxidative stress, while it impairs sweating through increasing oxidative stress during exposure to an ambient heat stress before and following exercise.

  8. Can intradermal administration of angiotensin II influence human heat loss responses during whole body heat stress?

    PubMed Central

    Fujii, Naoto; Meade, Robert D.; Paull, Gabrielle; McGinn, Ryan; Foudil-bey, Imane; Akbari, Pegah

    2015-01-01

    It is unclear if angiotensin II, which can increase the production of reactive oxygen species (oxidative stress), modulates heat loss responses of cutaneous blood flow and sweating. We tested the hypothesis that angiotensin II-induced increases in oxidative stress impair cutaneous perfusion and sweating during rest and exercise in the heat. Eleven young (24 ± 4 yr) healthy adults performed two 30-min cycling bouts at a fixed rate of metabolic heat production (400 W) in the heat (35°C). The first and second exercises were followed by a 20- and 40-min recovery. Four microdialysis fibers were placed in the forearm skin for continuous administration of either: 1) lactated Ringer (control), 2) 10 μM angiotensin II, 3) 10 mM ascorbate (an antioxidant), or 4) a combination of 10 μM angiotensin II + 10 mM ascorbate. Cutaneous vascular conductance (CVC; laser-Doppler perfusion units/mean arterial pressure) and sweating (ventilated capsule) were evaluated at each skin site. Compared with control, angiotensin II reduced both CVC and sweating at baseline resting and during each recovery in the heat (all P < 0.05). However, during both exercise bouts, there were no differences in CVC or sweating between the treatment sites (all P > 0.05). When ascorbate was coinfused with angiotensin II, the effect of angiotensin II on sweating was abolished (all P > 0.05); however, its effect on CVC at baseline resting and during each recovery remained intact (all P < 0.05). We show angiotensin II impairs cutaneous perfusion independent of oxidative stress, while it impairs sweating through increasing oxidative stress during exposure to an ambient heat stress before and following exercise. PMID:25767030

  9. 10 CFR 16.13 - Procedures for centralized administrative offset.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... collected. (f) Fees. Agencies that perform centralized salary offset computer matching services may charge a... made. The disbursing official may deduct the amount of the erroneous offset payment from future...

  10. 16 CFR Appendix I to Part 305 - Heating Performance and Cost for Central Air Conditioners

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Heating Performance and Cost for Central Air... RULEâ) Pt. 305, App. I Appendix I to Part 305—Heating Performance and Cost for Central Air Conditioners Manufacturer's rated heating capacity (Btu's/hr.) Range of HSPF's Low High Single Package Units Heat...

  11. 16 CFR Appendix I to Part 305 - Heating Performance and Cost for Central Air Conditioners

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Heating Performance and Cost for Central Air... RULEâ) Pt. 305, App. I Appendix I to Part 305—Heating Performance and Cost for Central Air Conditioners Manufacturer's rated heating capacity (Btu's/hr.) Range of HSPF's Low High Single Package Units Heat...

  12. 16 CFR Appendix I to Part 305 - Heating Performance and Cost for Central Air Conditioners

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Heating Performance and Cost for Central Air... RULEâ) Pt. 305, App. I Appendix I to Part 305—Heating Performance and Cost for Central Air Conditioners Manufacturer's rated heating capacity (Btu's/hr.) Range of HSPF's Low High Single Package Units Heat...

  13. 16 CFR Appendix I to Part 305 - Heating Performance and Cost for Central Air Conditioners

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Heating Performance and Cost for Central Air... RULEâ) Pt. 305, App. I Appendix I to Part 305—Heating Performance and Cost for Central Air Conditioners Manufacturer's rated heating capacity (Btu's/hr.) Range of HSPF's Low High Single Package Units Heat...

  14. Research on central heating system control strategy based on genetic algorithm

    NASA Astrophysics Data System (ADS)

    Ding, Sa; Yang, Jianhua; Lu, Wei; Duan, Zhipeng

    2017-03-01

    The central heating is a major way of warming in northeast China in winter, however, the traditional heating method is inefficient, intensifying the energy consumption. How to improve the heating efficiency and reduce energy waste attracts more and more attentions in our country. In this paper, the mathematical model of heat transfer station temperature control system was established based on the structure of central heating system. The feedforward-feedback control strategy was used to overcome temperature fluctuations caused by the pressurized heating exchange system. The genetic algorithm was used to optimize the parameters of PID controller and simulation results demonstrated that central heating temperature achieved well control effect and meet stabilization requirements.

  15. 16 CFR Appendix I to Part 305 - Heating Performance and Cost for Central Air Conditioners

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Heating Performance and Cost for Central Air... CONSERVATION ACT (âENERGY LABELING RULEâ) Pt. 305, App. I Appendix I to Part 305—Heating Performance and Cost for Central Air Conditioners Manufacturer's rated heating capacity (Btu's/hr.) Range of HSPF's...

  16. 19 CFR 351.103 - Central Records Unit and Administrative Protective Order and Dockets Unit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    .... and 5 p.m. on business days. Among other things, the Central Records Unit is responsible for... the APO/Dockets Unit are between 8:30 a.m. and 5 p.m. on business days. Among other things, the APO... 19 Customs Duties 3 2011-04-01 2011-04-01 false Central Records Unit and Administrative...

  17. Professional Development to Enhance Instructional Leadership and Practice of Central Office Administrators

    ERIC Educational Resources Information Center

    McCue, Cheryl A. R.

    2016-01-01

    Decades of research and practice suggest that educational administrators need to experience opportunities for professional development and continuous learning. This project study addressed the problem regarding the lack of a formal or systemic plan for professional development of central office administrators in a large suburban school district in…

  18. CAIS standard manual. System number 28. Central heating plants

    SciTech Connect

    1995-04-28

    At this installation the list of facilities to be surveyed will be addressed on the basis of 32 unique systems that form the CAIS Engineering Deficiency Standards and Inspection Methods document. Each system deals with a specific technical aspect of the facility to be surveyed. Within each system a further breakdown is made to subsystems, each having a specific list of components. Specific observations of the listed defects are provided so as to allow the entry of observed quantification data. A DOD CAIS manual is provided for each of the 32 systems with an internal organization. The System Tree is a graphical representation of the Work Breakdown Structure, showing system, subsystem and component relationships for the Central Heating Plants.

  19. Central apelin-13 administration modulates hypothalamic control of feeding.

    PubMed

    Ferrante, C; Orlando, G; Recinella, L; Leone, S; Chiavaroli, A; Di Nisio, C; Shohreh, R; Manippa, F; Ricciuti, A; Vacca, M; Brunetti, L

    2016-01-01

    The 77 amino prepropeptide apelin has been isolated from bovine stomach tissue and several smaller fragments, including apelin-13, showed high affinity for the orphan APJ receptor. The distribution of apelinergic fibers and receptors in the hypothalamus may suggest a role of apelin-13 on energy balance regulation, albeit the studies reporting the acute effects of apelin on feeding control are inconsistent. Considering the possible involvement of apelinergic system on hypothalamic appetite controlling network, in the present study we evaluated in the rat the effects of intrahypothalamic apelin-13 injection on food intake and the involvement of orexigenic and anorexigenic hypothalamic peptides and neurotransmitters. Eighteen rats (6 for each group of treatment) were injected into the ARC with either vehicle or apelin-13 (1-2 μg/rat). Food intake and hypothalamic peptide and neurotransmitter levels were evaluated 2 and 24 h after injection. Compared to vehicle, apelin-13 administration increased food intake both 2 and 24 h following treatment. This effect could be related to inhibited cocaine- and amphetamine-regulated transcript (CART) gene expression and serotonin (5-hydroxytryptamine, 5-HT) synthesis and release, and increased orexin A gene expression in the hypothalamus.

  20. District Central Office Leadership as Teaching: How Central Office Administrators Support Principals' Development as Instructional Leaders

    ERIC Educational Resources Information Center

    Honig, Meredith I.

    2012-01-01

    Purpose: Research on educational leadership underscores the importance of principals operating as instructional leaders and intensive job-embedded supports for such work; this research also identifies central office staff as key support providers. However, it teaches little about what central office staff do when they provide such support and how…

  1. How much Energy is Embodied in your Central Heating Boiler?

    NASA Astrophysics Data System (ADS)

    Koubogiannis, D.; Nouhou, C.

    2016-11-01

    Life Cycle Analysis (LCA) is an important tool in current research to quantitatively assess energy consumption and environmental impact of a building. In the context of LCA, the Embodied Energy (EE) related to the building and the corresponding Embodied CO2 emissions are valuable data. In such a case, these data concern the constitutive materials of the building and any subsystem, component or equipment in it. Usually, after calculating the mass of these materials, embodied energy values are estimated multiplying them by the corresponding EE coefficients concerning the production of these materials (EEMP). However, apart from transportation energy costs, another part of EE is that consumed for the manufacturing of any item as a finished product. The present work focuses on the manufacturing EE (EEMFG) of central heating boilers in Hellenic dwellings. Six typical boilers of different types are studied. Each of them is analyzed to its constitutive materials and its EEMP is estimated. For four of them, the boiler house where it was constructed in Greece was visited and data were collected. Based on them the corresponding boiler EEMFG values are estimated. The results concerning the EE for material production and manufacturing, as well as the results concerning the corresponding ECO2 values are discussed and assessed. Benchmark values correlating EE and ECO2 with the mass or the heat rate of the boiler are extracted.

  2. Oral Pyridostigmine Administration in Rats: Effects on Thermoregulation, Clinical Chemistry, and Performance in the Heat

    DTIC Science & Technology

    1984-01-01

    PERIOD COVERED " N Oral pyridostigmine administration in rats: .T 0 PTPR C E -,effects a thermoregulation, clinical chemistry , and performance in the heat...thermoregulation, clinical chemistry , and performance in the heat R. Francesconi, R. Hubbard, C. Matthew, N. Leva, J. Youxng, and V. Pense US Amny

  3. Psychophysical and cerebral responses to heat stimulation in patients with central pain, painless central sensory loss, and in healthy persons.

    PubMed

    Casey, Kenneth L; Geisser, Michael; Lorenz, Jürgen; Morrow, Thomas J; Paulson, Pamela; Minoshima, Satoshi

    2012-02-01

    Patients with central pain (CP) typically have chronic pain within an area of reduced pain and temperature sensation, suggesting an impairment of endogenous pain modulation mechanisms. We tested the hypothesis that some brain structures normally activated by cutaneous heat stimulation would be hyperresponsive among patients with CP but not among patients with a central nervous system lesion causing a loss of heat or nociceptive sensation with no pain (NP). We used H(2)(15)O positron emission tomography to measure, in 15 healthy control participants, 10 NP patients, and 10 CP patients, increases in regional cerebral blood flow among volumes of interest (VOI) from the resting (no stimulus) condition during bilateral contact heat stimulation at heat detection, heat pain threshold, and heat pain tolerance levels. Both patient groups had a reduced perception of heat intensity and unpleasantness on the clinically affected side and a bilateral impairment of heat detection. Compared with the HC group, both NP and CP patients had more hyperactive and hypoactive VOI in the resting state and more hyperresponsive and hyporesponsive VOI during heat stimulation. Compared with NP patients, CP patients had more hyperresponsive VOI in the intralaminar thalamus and sensory-motor cortex during heat stimulation. Our results show that focal CNS lesions produce bilateral sensory deficits and widespread changes in the nociceptive excitability of the brain. The increased nociceptive excitability within the intralaminar thalamus and sensory-motor cortex of our sample of CP patients suggests an underlying pathophysiology for the pain in some central pain syndromes.

  4. Climate change, workplace heat exposure, and occupational health and productivity in Central America.

    PubMed

    Kjellstrom, Tord; Crowe, Jennifer

    2011-01-01

    Climate change is increasing heat exposure in places such as Central America, a tropical region with generally hot/humid conditions. Working people are at particular risk of heat stress because of the intrabody heat production caused by physical labor. This article aims to describe the risks of occupational heat exposure on health and productivity in Central America, and to make tentative estimates of the impact of ongoing climate change on these risks. A review of relevant literature and estimation of the heat exposure variable wet bulb globe temperature (WBGT) in different locations within the region were used to estimate the effects. We found that heat stress at work is a real threat. Literature from Central America and heat exposure estimates show that some workers are already at risk under current conditions. These conditions will likely worsen with climate change, demonstrating the need to create solutions that will protect worker health and productivity.

  5. Central Administration of Galanin Receptor 1 Agonist Boosted Insulin Sensitivity in Adipose Cells of Diabetic Rats

    PubMed Central

    Zhang, Zhenwen; Fang, Penghua; He, Biao; Guo, Lili; Runesson, Johan; Langel, Ülo; Shi, Mingyi; Zhu, Yan; Bo, Ping

    2016-01-01

    Our previous studies testified the beneficial effect of central galanin on insulin sensitivity of type 2 diabetic rats. The aim of the study was further to investigate whether central M617, a galanin receptor 1 agonist, can benefit insulin sensitivity. The effects of intracerebroventricular administration of M617 on insulin sensitivity and insulin signaling were evaluated in adipose tissues of type 2 diabetic rats. The results showed that central injection of M617 significantly increased plasma adiponectin contents, glucose infusion rates in hyperinsulinemic-euglycemic clamp tests, GLUT4 mRNA expression levels, GLUT4 contents in plasma membranes, and total cell membranes of the adipose cells but reduced the plasma C-reactive protein concentration in nondiabetic and diabetic rats. The ratios of GLUT4 contents were higher in plasma membranes to total cell membranes in both nondiabetic and diabetic M617 groups than each control. In addition, the central administration of M617 enhanced the ratios of pAkt/Akt and pAS160/AS160, but not phosphorylative cAMP response element-binding protein (pCREB)/CREB in the adipose cells of nondiabetic and diabetic rats. These results suggest that excitation of central galanin receptor 1 facilitates insulin sensitivity via activation of the Akt/AS160 signaling pathway in the fat cells of type 2 diabetic rats. PMID:27127795

  6. Central heating devices cause childhood injuries but rarely burns: a study in Greece.

    PubMed

    Petridou, Eleni; Alexe, Delia; Trichopoulos, Dimitrios

    2002-06-01

    Injuries related to central heating devices represent a non-negligible fraction of all indoor injuries among children with mechanical lesions, outnumbering burns. Prevention strategies refer mainly to modifications or safer use of the appliances and improvements in building design.

  7. Activation of mesolimbic dopaminergic neurons following central administration of histamine is mediated by H1 receptors.

    PubMed

    Fleckenstein, A E; Lookingland, K J; Moore, K E

    1993-01-01

    The effect of intracerebroventricular administration of histamine on the activity of mesolimbic and nigrostriatal dopaminergic (DA) neurons was determined in male rats. The activity of these neurons was estimated by measuring: (1) the accumulation of 3,4-dihydroxyphenylalanine (DOPA) after administration of a decarboxylase inhibitor, and (2) the concentration of 3,4-dihydroxyphenylacetic acid (DOPAC) in the nucleus accumbens and striatum, which contain the terminals of these neurons. Central administration of histamine increased both DOPA accumulation and DOPAC concentrations in the nucleus accumbens, but was without effect in the striatum. The increase in DOPAC concentrations in the nucleus accumbens occurred within 10 min and was sustained for at least 120 min. The H1 antagonist mepyramine blocked whereas the H2 antagonist zolantidine did not affect histamine-induced increases in DOPAC concentrations in the nucleus accumbens. Neither mepyramine nor zolantidine affected basal DOPAC concentrations in the nucleus accumbens. These results indicate that central administration of histamine stimulates mesolimbic DA neurons through an action at the H1 receptor, but has no effect upon the activity of nigrostriatal DA neurons.

  8. 16 CFR 305.12 - Labeling for central air conditioners, heat pumps, and furnaces.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... pumps, and furnaces. 305.12 Section 305.12 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... air conditioners, heat pumps, and furnaces. (a) Layout. All energy labels for central air conditioners, heat pumps, and furnaces (including boilers) shall use one size, similar colors, and typefaces...

  9. 10 CFR 429.16 - Central air conditioners and heat pumps.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CONSUMER PRODUCTS AND COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.16 Central air conditioners... mean divided by 1.05, where: ER02MY11.030 and (B) Any represented value of the energy efficiency or other measure of energy consumption of the central air conditioner or heat pump for which...

  10. 10 CFR 429.16 - Central air conditioners and heat pumps.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CONSUMER PRODUCTS AND COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.16 Central air conditioners... mean divided by 1.05, where: ER02MY11.030 and (B) Any represented value of the energy efficiency or other measure of energy consumption of the central air conditioner or heat pump for which...

  11. 10 CFR 429.16 - Central air conditioners and heat pumps.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CONSUMER PRODUCTS AND COMMERCIAL AND INDUSTRIAL EQUIPMENT Certification § 429.16 Central air conditioners... mean divided by 1.05, where: ER02MY11.030 and (B) Any represented value of the energy efficiency or other measure of energy consumption of the central air conditioner or heat pump for which...

  12. Heat sources for tertiary metamorphism and anatexis in the Annapurna-Manaslu region, central Nepal

    NASA Technical Reports Server (NTRS)

    England, Philip; Le Fort, Patrick; Molnar, Peter; Pecher, Arnaud

    1992-01-01

    The metamorphic evolution of the rocks near the Main Central Thrust in the Annapurna-Manaslu region of central Nepal is examined. In this region, all three types of metamorphic features can be observed: regional metamorphism, anatectic granitoids, and inverted metamorphic isograds. In this work, each phase of metamorphism is treated separately to estimate the heat sources required for each process. This approach makes it possible to identify the important parameters for each process, to draw preliminary conclusions about the heat sources required for each of these phases, and to determine which parameters need to be measured more precisely in order to constrain these heat sources.

  13. Effects of passive heating on central blood volume and ventricular dimensions in humans.

    PubMed

    Crandall, C G; Wilson, T E; Marving, J; Vogelsang, T W; Kjaer, A; Hesse, B; Secher, N H

    2008-01-01

    Mixed findings regarding the effects of whole-body heat stress on central blood volume have been reported. This study evaluated the hypothesis that heat stress reduces central blood volume and alters blood volume distribution. Ten healthy experimental and seven healthy time control (i.e. non-heat stressed) subjects participated in this protocol. Changes in regional blood volume during heat stress and time control were estimated using technetium-99m labelled autologous red blood cells and gamma camera imaging. Whole-body heating increased internal temperature (> 1.0 degrees C), cutaneous vascular conductance (approximately fivefold), and heart rate (52 +/- 2 to 93 +/- 4 beats min(-1)), while reducing central venous pressure (5.5 +/- 07 to 0.2 +/- 0.6 mmHg) accompanied by minor decreases in mean arterial pressure (all P < 0.05). The heat stress reduced the blood volume of the heart (18 +/- 2%), heart plus central vasculature (17 +/- 2%), thorax (14 +/- 2%), inferior vena cava (23 +/- 2%) and liver (23 +/- 2%) (all P heat stress did not significantly change left ventricular end-diastolic volume, while ventricular end-systolic volume was reduced by 24 +/- 6% of pre-heat stress levels (P < 0.001 relative to time control subjects). Thus, heat stress increased left ventricular ejection fraction from 60 +/- 1% to 68 +/- 2% (P = 0.02). We conclude that heat stress shifts blood volume from thoracic and splanchnic regions presumably to aid in heat dissipation, while simultaneously increasing heart rate and ejection fraction.

  14. Malathion Administration: Effects on Physiological and Physical Performance in the Heat,

    DTIC Science & Technology

    1982-12-09

    chronic chlorpromazine administration compromises the ability to work in the heat, the effects of atropine singly or in combination with organophosphate...more potent insecticide, parathion, had effects on hemoglobin concentration or kidney and liver organ weight to body weight ratios. Paul et al. (26...that consumption of up to 5 ppm parathion in food for 42 days had no significant effects on the organ to body weight ratios of heart, brain, liver

  15. Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system

    PubMed Central

    McGowan, Jeremy WD; Shao, Qingmei; Vig, Parminder JS; Bidwell, Gene L

    2016-01-01

    Bypassing the blood–brain barrier is one of the primary considerations when designing compounds intended to function in the central nervous system (CNS). Intranasal (IN) administration of otherwise blood–brain barrier impermeable molecules can result in high CNS concentrations and low systemic accumulation, indicating that IN administration may be a useful method of delivering therapeutics to the CNS. Elastin-like polypeptide (ELP) is a large, non-immunogenic, highly manipulable biopolymer with extensive evidence supporting its use as a carrier with the ability to improve drug pharmacokinetics and drug targeting. The ability of ELP to reach the CNS via IN administration has been shown previously. Previous studies have also identified the ability of cell penetrating peptides (CPPs) to increase the uptake of molecules in some instances, including via the IN route. Here, we compared and contrasted the biodistribution of ELPs with or without addition of the CPPs Tat or SynB1 via both the IN and intravenous routes. Administration of ELP via the IN route led to significant accumulation in the brain, especially in the olfactory bulbs. When injected intravenously, <3% of the ELP signal was present outside the vascular compartment. This contrasted with IN administration, which resulted in 79% of the fluorescence signal localized outside the vascular space. The fusion of Tat or SynB1 significantly altered the biodistribution of ELP, decreasing the total CNS accumulation following IN administration. The addition of CPPs to ELP increased their retention in the nasal epithelium. These results suggest ELP may represent an effective CNS delivery vector without further modification and that the addition of a CPP significantly influences biodistribution. PMID:27660412

  16. Intranasal administration of elastin-like polypeptide for therapeutic delivery to the central nervous system.

    PubMed

    McGowan, Jeremy Wd; Shao, Qingmei; Vig, Parminder Js; Bidwell, Gene L

    Bypassing the blood-brain barrier is one of the primary considerations when designing compounds intended to function in the central nervous system (CNS). Intranasal (IN) administration of otherwise blood-brain barrier impermeable molecules can result in high CNS concentrations and low systemic accumulation, indicating that IN administration may be a useful method of delivering therapeutics to the CNS. Elastin-like polypeptide (ELP) is a large, non-immunogenic, highly manipulable biopolymer with extensive evidence supporting its use as a carrier with the ability to improve drug pharmacokinetics and drug targeting. The ability of ELP to reach the CNS via IN administration has been shown previously. Previous studies have also identified the ability of cell penetrating peptides (CPPs) to increase the uptake of molecules in some instances, including via the IN route. Here, we compared and contrasted the biodistribution of ELPs with or without addition of the CPPs Tat or SynB1 via both the IN and intravenous routes. Administration of ELP via the IN route led to significant accumulation in the brain, especially in the olfactory bulbs. When injected intravenously, <3% of the ELP signal was present outside the vascular compartment. This contrasted with IN administration, which resulted in 79% of the fluorescence signal localized outside the vascular space. The fusion of Tat or SynB1 significantly altered the biodistribution of ELP, decreasing the total CNS accumulation following IN administration. The addition of CPPs to ELP increased their retention in the nasal epithelium. These results suggest ELP may represent an effective CNS delivery vector without further modification and that the addition of a CPP significantly influences biodistribution.

  17. [The Protomedicato Tribunal in the Central Administration of the Spanish Crown].

    PubMed

    Campos Díez, M S

    1996-01-01

    The Protomedicato was born, developed, and declined in the central administration of the Castilian Kingdom during the historic period known as the Modern Age (15th-19th centuries). The main objective of this study was to produce a conceptual analysis of this royal institution, a high collegiate court of technical character whose aim was to control all health-related professions in Castile; it had an independent jurisdiction and was not subordinate to the Royal Council (Consejo Real), although it was sometimes influenced by this council. We studied the legislative and everyday life and evolution of this court through different stages in its long life span. The Protomedicato, considered not as an isolated institution but within the bureaucracy of modern administration, is analyzed in the context of its sometimes strained relationship with other national, regional and local institutions of the Kingdom, the University, the Church and the Professional Association.

  18. Hot-spot heating in central-station arrays

    NASA Technical Reports Server (NTRS)

    Gonzalez, C. C.

    1983-01-01

    Hot spot tests performed on the Sacramento Municipal Utility District (SMUD) verificaton array show that current imbalance occurs, resulting in significant hot spot heating. One cause of current imbalance is differences in the average shunt resistances of parallel cell strings due to cell shunt resistance variations. In depth hot spot tests are performed on the verification array with bypass diodes. The tests had several objectives: (1) a comparison of hot spot temperatures achieved under field conditions with those obtained with the present laboratory hot spot test using similar modules; (2) an assessment of current imbalance versus cross tie frequency; and (3) an assessment of different shadow patterns and shadow densities. Instrumented modules are used to vary the number of cross ties and to measure the test-cell current and back-bias voltage. The widths, lengths, and densities of the shadows are varied to maximize the back bias voltage at maximum power current. An infrared camera is used to indicate the existence of hot spots and estimate temperature increases in conjunction with thermocouples. The results of these hot spot tests indicate a sensitivity of back bias heating to the shadow size (amount of cell coverage) and density.

  19. Solar augmentation for process heat with central receiver technology

    NASA Astrophysics Data System (ADS)

    Kotzé, Johannes P.; du Toit, Philip; Bode, Sebastian J.; Larmuth, James N.; Landman, Willem A.; Gauché, Paul

    2016-05-01

    Coal fired boilers are currently one of the most widespread ways to deliver process heat to industry. John Thompson Boilers (JTB) offer industrial steam supply solutions for industry and utility scale applications in Southern Africa. Transport cost add significant cost to the coal price in locations far from the coal fields in Mpumalanga, Gauteng and Limpopo. The Helio100 project developed a low cost, self-learning, wireless heliostat technology that requires no ground preparation. This is attractive as an augmentation alternative, as it can easily be installed on any open land that a client may have available. This paper explores the techno economic feasibility of solar augmentation for JTB coal fired steam boilers by comparing the fuel savings of a generic 2MW heliostat field at various locations throughout South Africa.

  20. Designing for the home: a comparative study of support aids for central heating systems.

    PubMed

    Sauer, J; Wastell, D G; Schmeink, C

    2009-03-01

    The study examined the influence of different types of enhanced system support on user performance during the management of a central heating system. A computer-based simulation of a central heating system, called CHESS V2.0, was used to model different interface options, providing different support facilities to the user (e.g., historical, predictive, and instructional displays). Seventy-five participants took part in the study and completed a series of operational scenarios under different support conditions. The simulation environment allowed the collection of performance measures (e.g., energy consumption), information sampling, and system control behaviour. Subjective user evaluations of various aspects of the system were also measured. The results showed performance gains for predictive displays whereas no such benefits were observed for the other display types. The data also revealed that status and predictive displays were valued most highly by users. The implications of the findings for designers of central heating systems are discussed.

  1. System design package for the solar heating and cooling central data processing system

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The central data processing system provides the resources required to assess the performance of solar heating and cooling systems installed at remote sites. These sites consist of residential, commercial, government, and educational types of buildings, and the solar heating and cooling systems can be hot-water, space heating, cooling, and combinations of these. The instrumentation data associated with these systems will vary according to the application and must be collected, processed, and presented in a form which supports continuity of performance evaluation across all applications. Overall software system requirements were established for use in the central integration facility which transforms raw data collected at remote sites into performance evaluation information for assessing the performance of solar heating and cooling systems.

  2. Effects of central galanin administration on muscarinic cholinergic and galanin receptor G protein coupling.

    PubMed

    Barreda-Gómez, G; Giralt, M T; Rodríguez-Puertas, R

    2005-06-01

    The neuropeptide galanin is expressed in the mammalian central nervous system and has been implicated in neurotrophic actions. Central galanin administration induces cognitive deficits in rodents and inhibits the release of acetylcholine in the hippocampus. In addition, a galanin hyperinnervation of the basal forebrain cholinergic cells in Alzheimer's disease patients has been reported. To evaluate the effect of galanin treatment on galanin and muscarinic cholinergic receptor G protein coupling, galanin was administered into the lateral ventricle of rats via an implanted cannula. Galanin or muscarinic receptor functional coupling to G proteins was quantified by galanin or carbachol stimulation of guanosine 5'-(gamma-[35S]thio)triphosphate binding in rat brain slices. Guanosine 5'-(gamma-[35S]thio)triphosphate basal binding in nucleus basalis of Meynert and thalamic nuclei was increased in the vehicle treated group. This effect was reverted by galanin treatment and indicates that the surgery increased receptor functional coupling to G proteins, which is restored by a possible neurotrophic action mediated by galanin. In addition, in galanin administered animals, galanin-stimulated binding was increased in the amygdala but decreased in the diagonal band, whilst binding stimulation mediated by carbachol was found to be increased in the amygdala, thalamic nuclei and diagonal band. These findings indicate that galanin treatment modulates the coupling of galanin and muscarinic cholinergic receptors to G proteins in specific regions of the rat central nervous system.

  3. Knowledge Level on Administration of Chemotherapy through Peripheral and Central Venous Catheter among Oncology Nurses

    PubMed Central

    Kapucu, Sevgisun; Özkaraman, Ayşe Özaydın; Uysal, Neşe; Bagcivan, Gulcan; Şeref, Ferhan Çetin; Elöz, Aygül

    2017-01-01

    Objective: The aim of this study is to determine the knowledge levels of oncology nurses about peripheral and central venous catheter during their chemotherapy administration. Methods: Data collection of this descriptive study was started on April 15, 2015–July 15, 2015. The data presented in this summary belong to 165 nurses. Data were collected with data collection form including questions related to sociodemographic qualifications and knowledge levels of nurses. Data collection forms were E-mailed to the members of Turkish Oncology Nursing Society. Data presented with numbers, percentages, and mean ± standard deviation. Results: The mean age of nurses was 33.60 ± 7.34 years and mean duration for oncology nursing experience was 2.65 ± 0.91 years. Nurses had correct information about the importance of selecting peripheral venous catheter and choosing the placement area for chemotherapy administration (63.6%), control of catheter before the administration (93.9%), influence of chemotherapeutic agent on length of catheter (40.6%), and management of extravasation (75.7%). Nurses also had correct information about the first use of port catheter (67.3%) and checking the catheter whether it is working properly or not (75.8%). Conclusions: In General, nurses’ level of knowledge related to catheter is 50% and higher. It is recommended to increase the knowledge of nurses about evidence-based information for catheter care as a step to safe chemotherapy practice. PMID:28217732

  4. Distinct BOLD Activation Profiles Following Central and Peripheral Oxytocin Administration in Awake Rats

    PubMed Central

    Ferris, Craig F.; Yee, Jason R.; Kenkel, William M.; Dumais, Kelly Marie; Moore, Kelsey; Veenema, Alexa H.; Kulkarni, Praveen; Perkybile, Allison M.; Carter, C. Sue

    2015-01-01

    A growing body of literature has suggested that intranasal oxytocin (OT) or other systemic routes of administration can alter prosocial behavior, presumably by directly activating OT sensitive neural circuits in the brain. Yet there is no clear evidence that OT given peripherally can cross the blood–brain barrier at levels sufficient to engage the OT receptor. To address this issue we examined changes in blood oxygen level-dependent (BOLD) signal intensity in response to peripheral OT injections (0.1, 0.5, or 2.5 mg/kg) during functional magnetic resonance imaging (fMRI) in awake rats imaged at 7.0 T. These data were compared to OT (1 μg/5 μl) given directly to the brain via the lateral cerebroventricle. Using a 3D annotated MRI atlas of the rat brain segmented into 171 brain areas and computational analysis, we reconstructed the distributed integrated neural circuits identified with BOLD fMRI following central and peripheral OT. Both routes of administration caused significant changes in BOLD signal within the first 10 min of administration. As expected, central OT activated a majority of brain areas known to express a high density of OT receptors, e.g., lateral septum, subiculum, shell of the accumbens, bed nucleus of the stria terminalis. This profile of activation was not matched by peripheral OT. The change in BOLD signal to peripheral OT did not show any discernible dose–response. Interestingly, peripheral OT affected all subdivisions of the olfactory bulb, in addition to the cerebellum and several brainstem areas relevant to the autonomic nervous system, including the solitary tract nucleus. The results from this imaging study do not support a direct central action of peripheral OT on the brain. Instead, the patterns of brain activity suggest that peripheral OT may interact at the level of the olfactory bulb and through sensory afferents from the autonomic nervous system to influence brain activity. PMID:26441574

  5. Developing a strategy for improving efficiency in the heating sector in central and eastern Europe

    SciTech Connect

    Meyer, A.S.

    1995-12-31

    Heating is a vital energy service in Central and Eastern Europe, but the current delivery mechanisms are riddled with problems. District heating (DH) in its present technical form and with the present management structures is an inefficient system which produces expensive heat. Customers cannot control it and react to overheating by opening windows, even in winter. DH facilities together with other forms of individual heating are responsible for air pollution, causing severe impacts on the health of urban residents. The issues relating to DH are discussed, the first World Bank activities and experiences with projects in Poland are analyzed, and the cornerstones of a strategy to support future World Bank financing and the development of sound heating policies in CEE are presented.

  6. Climate change scenarios of heat waves in Central Europe and their uncertainties

    NASA Astrophysics Data System (ADS)

    Lhotka, Ondřej; Kyselý, Jan; Farda, Aleš

    2017-01-01

    The study examines climate change scenarios of Central European heat waves with a focus on related uncertainties in a large ensemble of regional climate model (RCM) simulations from the EURO-CORDEX and ENSEMBLES projects. Historical runs (1970-1999) driven by global climate models (GCMs) are evaluated against the E-OBS gridded data set in the first step. Although the RCMs are found to reproduce the frequency of heat waves quite well, those RCMs with the coarser grid (25 and 50 km) considerably overestimate the frequency of severe heat waves. This deficiency is improved in higher-resolution (12.5 km) EURO-CORDEX RCMs. In the near future (2020-2049), heat waves are projected to be nearly twice as frequent in comparison to the modelled historical period, and the increase is even larger for severe heat waves. Uncertainty originates mainly from the selection of RCMs and GCMs because the increase is similar for all concentration scenarios. For the late twenty-first century (2070-2099), a substantial increase in heat wave frequencies is projected, the magnitude of which depends mainly upon concentration scenario. Three to four heat waves per summer are projected in this period (compared to less than one in the recent climate), and severe heat waves are likely to become a regular phenomenon. This increment is primarily driven by a positive shift of temperature distribution, but changes in its scale and enhanced temporal autocorrelation of temperature also contribute to the projected increase in heat wave frequencies.

  7. 16 CFR 305.12 - Labeling for central air conditioners, heat pumps, and furnaces.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... pumps, and furnaces. 305.12 Section 305.12 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... pumps, and furnaces. (a) Layout. All energy labels for central air conditioners, heat pumps, and furnaces (including boilers) shall use one size, similar colors, and typefaces with consistent...

  8. 16 CFR 305.12 - Labeling for central air conditioners, heat pumps, and furnaces.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... pumps, and furnaces. 305.12 Section 305.12 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... pumps, and furnaces. (a) Layout. All energy labels for central air conditioners, heat pumps, and furnaces (including boilers) shall use one size, similar colors, and typefaces with consistent...

  9. 16 CFR 305.12 - Labeling for central air conditioners, heat pumps, and furnaces.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... pumps, and furnaces. 305.12 Section 305.12 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... pumps, and furnaces. (a) Layout. All energy labels for central air conditioners, heat pumps, and furnaces (including boilers) shall use one size, similar colors, and typefaces with consistent...

  10. 16 CFR 305.12 - Labeling for central air conditioners, heat pumps, and furnaces.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... pumps, and furnaces. 305.12 Section 305.12 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS... pumps, and furnaces. (a) Layout. All energy labels for central air conditioners, heat pumps, and furnaces (including boilers) shall use one size, similar colors, and typefaces with consistent...

  11. No influence of lower leg heating on central arterial pulse pressure in young men.

    PubMed

    Kosaki, Keisei; Sugawara, Jun; Akazawa, Nobuhiko; Tanahashi, Koichiro; Kumagai, Hiroshi; Ajisaka, Ryuichi; Maeda, Seiji

    2015-07-01

    Central arterial pulse pressure (PP), a strong predictor of cardiovascular disease, mainly consists of an incident wave generated by left ventricular ejection and a late-arriving reflected wave emanating from the lower body. We have tested the hypothesis that a reduction in leg vascular tone by heat treatment of the lower leg attenuates the central arterial PP. Pressure and wave properties of the peripheral and central arteries were measured in eight young men before and after heat treatment of the lower leg (temperature approx. 43 °C) for 30 and 60 min, respectively. Following the lower leg heat trial, leg (femoral-ankle) pulse wave velocity (PWV) was significantly decreased, but aortic (carotid-femoral) PWV and parameters of wave reflection and carotid arterial PP did not change significantly. No significant changes were observed in these parameters in the control trial. These results suggest that the reduction in leg vascular tone induced by heat treatment of the lower leg may not affect wave reflection and central arterial PP in young men.

  12. Advective heat transport associated with regional Earth degassing in central Apennine (Italy)

    NASA Astrophysics Data System (ADS)

    Chiodini, G.; Cardellini, C.; Caliro, S.; Chiarabba, C.; Frondini, F.

    2013-07-01

    In this work we show that the main springs of the central Apennine transport a total amount of heat of ˜2.2×109 J s-1. Most of this heat (57%) is the result of geothermal warming while the remaining 43% is due to gravitational potential energy dissipation. This result indicates that a large area of the central Apennines is very hot with heat flux values >300 mW m-2. These values are higher than those measured in the magmatic and famously geothermal provinces of Tuscany and Latium and about 1/3 of the total heat discharged at Yellowstone. This finding is surprising because the central Apennines have been thought to be a relatively cold area. Translated by CO2 rich fluids, this heat anomaly suggests the existence of a thermal source such as a large magmatic intrusion at depth. Recent tomographic images of the area support the presence of such an intrusion visible as a broad negative velocity anomaly in seismic waves. Our results indicate that the thermal regime of tectonically active areas of the Earth, where meteoric waters infiltrate and deeply circulate, should be revised on the basis of mass and energy balances of the groundwater systems.

  13. Central nervous insulin administration does not potentiate the acute glucoregulatory impact of concurrent mild hyperinsulinemia.

    PubMed

    Ott, Volker; Lehnert, Hendrik; Staub, Josefine; Wönne, Kathrin; Born, Jan; Hallschmid, Manfred

    2015-03-01

    Experiments in rodents suggest that hypothalamic insulin signaling essentially contributes to the acute control of peripheral glucose homeostasis. Against this background, we investigated in healthy humans whether intranasal (IN) insulin, which is known to effectively reach the brain compartment, impacts systemic glucose metabolism. Twenty overnight-fasted healthy, normal-weight men were IN administered 210 and 420 international units [IU] (10 and 20 IU every 15 min) of the insulin analog aspart (ins-asp) and placebo, respectively, during experimental sessions lasting 6 h. The use of ins-asp rather than human insulin enabled us to disentangle exogenous and endogenous insulin kinetics. IN insulin dose-dependently decreased plasma glucose concentrations while reducing C-peptide and attenuating endogenous insulin levels. However, we also observed a slight dose-dependent permeation of ins-asp into the circulation. In control experiments mimicking the systemic but not the central nervous uptake of the IN 210 IU dose via intravenous infusion of ins-asp at a dose of 0.12 IU/kg/24 h (n = 10), we obtained essentially identical effects on fasting plasma glucose concentrations. This pattern indicates that sustained IN insulin administration to the human brain to enhance central nervous insulin signaling does not acutely alter systemic glucose homeostasis beyond effects accounted for by concurrent mild hyperinsulinemia.

  14. Central administration of GPR55 receptor agonist and antagonist modulates anxiety-related behaviors in rats.

    PubMed

    Rahimi, Abbasali; Hajizadeh Moghaddam, Akbar; Roohbakhsh, Ali

    2015-04-01

    G-protein-coupled receptor 55 (GPR55) has been proposed as an atypical cannabinoid receptor, which is activated by lysophosphatidylinositols and some synthetic or endogenous cannabinoid molecules. The exact role of GPR55 receptors in the central nervous system especially in anxiety needs to be evaluated. In this study, the effects of intracerebroventricular (i.c.v.) administration of agonist and antagonist of GPR55 receptor on anxiety-related behaviors in rats were investigated. Here, O-1602 (GPR55 agonist) at the doses of 0.2, 1, and 5 μg/rat increased %OAT and %OAE but not the locomotor activity, showing an anxiolytic response, whereas i.c.v. injection of ML193 (GPR55 antagonist) at the doses of 0.1 and 1 μg/rat increased anxiety-like behaviors while causing locomotor impairment. The antagonistic effect of ML193 on the anxiolytic-like effect of O-1602 was also evaluated. The results showed that ML193 decreased the anxiolytic-like effect of O-1602. Based on these results, it may be concluded that central GPR55 may have a role in modulation of anxiety-like behaviors in rats. Further experiments are needed to elucidate the exact role of these receptors in anxiety.

  15. Mesoscale budgets of heat and moisture in a convective system over the central United States

    NASA Technical Reports Server (NTRS)

    Kuo, Y.-H.; Anthes, R. A.

    1984-01-01

    Mesoscale heat and moisture budget calculations from the April 10-11 AVE-SESAME central U.S. region are calculated in order to diagnose the effect of midlatitude organized convection on its environment. When averaged over an area greater than the observational scale, the noise levels of 5 C/day for the heat budget and 2 g/kg per day for the moisture budget are considerably reduced. The credibility of such area-averaged budget results is indicated by the general agreement obtained between the observed rainfall rate and the vertically integrated heat sources and moisture sinks. The vertical convective heating that is diagnosed from this organized midlatitude convection differs significantly from tropical structures diagnosed on much larger temporal and spatial scales. A time lag of several hours between the moisture convergence and rainfall rate is noted.

  16. Heat deposition into the superconducting central column of a spherical tokamak fusion plant

    NASA Astrophysics Data System (ADS)

    Windsor, C. G.; Morgan, J. G.; Buxton, P. F.

    2015-02-01

    A key challenge in designing a fusion power plant is to manage the heat deposition into the central core containing superconducting toroidal field coils. Spherical tokamaks have limited space for shielding the central core from fast neutrons produced by fusion and the resulting gamma rays. This paper reports a series of three-dimensional computations using the Monte Carlo N-particle code to calculate the heat deposition into the superconducting core. For a given fusion power, this is considered as a function of plasma major radius R0, core radius rsc and shield thickness d. Computations over the ranges 0.6 m ⩽ R0 ⩽ 1.6 m, 0.15 m ⩽ rsc ⩽ 0.25 m and 0.15 m ⩽ d ⩽ 0.4 m are presented. The deposited power shows an exponential dependence on all three variables to within around 2%. The additional effects of source profile, the outer shield and shield material are all considered. The results can be interpolated to 2% accuracy and have been successfully incorporated into a system code. A possible pilot plant with 174 MW of fusion is shown to lead to a heat deposition into the superconducting core of order 30 kW. An estimate of 1.7 MW is made for the cryogenic plant power necessary for heat removal, and of 88 s running time for an adiabatic experiment where the heat deposition is absorbed by a 10 K temperature rise.

  17. Heat flow and subsurface temperature distributions in central and western New York. Volume 2

    SciTech Connect

    Hodge, D.S.; Fromm, K.A.

    1982-08-01

    Existing data in western and central New York indicates the possibility of a low-temperature, direct-use geothermal resource. This report evaluates the heat flow and provides a representation of temperatures at depth in this area. This has been done by: (1) analyzing known temperature distributions, (2) measuring the thermal conductivity of sedimentary rock units. Based on this information, areas of higher-than-normal heat flow and temperatures in possible geothermal source reservoirs are described to aid in targeting areas for the exploitation of geothermal energy in New York.

  18. Different Behaviour of Heat Flow and Helium Anomalies Through the Geothermal Areas of Central Italy

    NASA Astrophysics Data System (ADS)

    Bellani, S.; Magro, G.

    2005-12-01

    The high enthalpy geothermal areas and more than 30% of the Italian spas are concentrated in central Italy (Tuscany and Latium regions). A wide part of this area is affected by a large heat-flow anomaly, with maxima corresponding to the geothermal fields of Larderello, Mt. Amiata and Latera. Mt.Amiata and Latera are located in areas of quaternary quiescent volcanism, while there are no outcrops of extrusive rocks in the Larderello geothermal field. Surface heat flow in a continental area has an average value of 50-60 mW/m2. The background regional value in these geothermal areas is 120-150 mW/m2, with peaks up to 1000 mW/m2 at Larderello, 600 mW/m2 at Mt. Amiata and 300 mW/m2 at Latera. Anomalous heat flow is very often related to the presence of 3He-enriched fluids. In central Italy the He isotopic ratio (3He/4He expressed as R/Ra), in gases from cold and thermal manifestations and in geothermal wells ranges from 0.2 to 3.2 R/Ra. In particular, Larderello fluids range between 0.5 and 3.2, while the interval for Mt. Amiata and Latera fluids spans from 0.2 to 0.6. The R/Ra and heat flow profiles through central Italy, NW-SE trending, show no straightforward correlation between the two parameters. A phased correlation exists between heat flow and R/Ra relative maxima at Larderello, while they are decoupled at Mt. Amiata and Latera geothermal fields. Different heat and He transport mechanisms through the crust are the most likely explanation: mantle 3He-enriched fluids move upwards mainly via fluid filled conduits, while heat diffuses faster than He throughout the entire bulk rock. At Larderello, the almost constant values of R/Ra in geothermal wells and paleo-fluids (fluid inclusions) indicate that the contribution of hot 3He-enriched fluids must have occurred through deeply rooted faults at least in the last 1 Ma. In the Mt. Amiata area the presence of several spas, marked by low R/Ra ratios down to crustal values, could indicate the addition of radiogenic 4He. Rock

  19. Oxytocin reduces background anxiety in a fear-potentiated startle paradigm: peripheral vs central administration.

    PubMed

    Ayers, Luke W; Missig, Galen; Schulkin, Jay; Rosen, Jeffrey B

    2011-11-01

    Oxytocin is known to have anti-anxiety and anti-stress effects. Using a fear-potentiated startle paradigm in rats, we previously demonstrated that subcutaneously administered oxytocin suppressed acoustic startle following fear conditioning compared with startle before fear conditioning (termed background anxiety), but did not have an effect on cue-specific fear-potentiated startle. The findings suggest oxytocin reduces background anxiety, an anxious state not directly related to cue-specific fear, but sustained beyond the immediate threat. The goal of the present study was to compare the effects of centrally and peripherally administered oxytocin on background anxiety and cue-specific fear. Male rats were given oxytocin either subcutaneously (SC) or intracerebroventricularly (ICV) into the lateral ventricles before fear-potentiated startle testing. Oxytocin doses of 0.01 and 0.1 μg/kg SC reduced background anxiety. ICV administration of oxytocin at doses from 0.002 to 20 μg oxytocin had no effect on background anxiety or cue-specific fear-potentiated startle. The 20 μg ICV dose of oxytocin did reduce acoustic startle in non-fear conditioned rats. These studies indicate that oxytocin is potent and effective in reducing background anxiety when delivered peripherally, but not when delivered into the cerebroventricular system. Oxytocin given systemically may have anti-anxiety properties that are particularly germane to the hypervigilance and exaggerated startle typically seen in many anxiety and mental health disorder patients.

  20. Antinociception induced by central administration of histamine in the formalin test in rats.

    PubMed

    Mojtahedin, Ali; Tamaddonfard, Esmaeal; Zanboori, Ali

    2008-01-01

    In the present study, effects of intracerebroventricular (icv) administration of histamine, mepyramine (H1-receptor antagonist) and famotidine (H2-receptor antagonist) have been investigated on the formalin test in rats. Subcutaneous injection of formalin (50 microl, 1%) into the ventral surface of the left hind paw produced a marked biphasic pain response (first phase: 0-5 min and second phase: 15-45 min). All the performed treatments did not significantly influence the first phase of pain. Histamine at the doses of 10 and 40 microg and mepyramine and famotidine at the same doses of 20 and 80 microg, significantly (P < 0.05) decreased the late phase of formalin-induced pain. Pretreatments with mepyramine and famotidine at the same dose of 80 microg, significantly (P < 0.05) prevented the histamine (40 microg)-induced antinociception. These results indicate that brain histamine produces antinociception, and both central H1 and H2 receptors may involve in the histamine-induced antinociception in the formalin test in rats.

  1. Central Heat and Power Plant Coal Dust and Silica Risk Management, Eielson Air Force Base, Alaska

    DTIC Science & Technology

    2014-12-11

    evaluation of potential ammonia exposures at the Eielson Air Force Base (EAFB) Central Heat and Power Plant (CHPP) following the installation of a new...boiler and emission controls. While the main purpose of the visit was an ammonia health risk assessment, the potential exposure to coal dust and...addition to the main ammonia health risk assessment letter and designed to inform EAFB of the status of the pending silica rule, exposure assessment

  2. Preliminary design review package for the solar heating and cooling central data processing system

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The Central Data Processing System (CDPS) is designed to transform the raw data collected at remote sites into performance evaluation information for assessing the performance of solar heating and cooling systems. Software requirements for the CDPS are described. The programming standards to be used in development, documentation, and maintenance of the software are discussed along with the CDPS operations approach in support of daily data collection and processing.

  3. ENERGY STAR Certified Non-AHRI Central Air Conditioner Equipment and Air Source Heat Pump

    EPA Pesticide Factsheets

    Certified models meet all ENERGY STAR requirements as listed in the Version 5.0 ENERGY STAR Program Requirements for Air Source Heat Pump and Central Air Conditioner Equipment that are effective as of September 15, 2015. A detailed listing of key efficiency criteria are available at http://www.energystar.gov/index.cfm?c=airsrc_heat.pr_crit_as_heat_pumps Listed products have been submitted to EPA by ENERGY STAR partners that do not participate in the AHRI certification program. EPA will continue to update this list with products that are certified by EPA-recognized certification bodies other than AHRI. The majority of ENERGY STAR products, certified by AHRI, can be found on the CEE/AHRI Verified Directory at http://www.ceedirectory.org/

  4. Teacher Stress and Administrative Support as Predictors of Teachers' Self-Efficacy for Special Education Teachers in California's Central Valley

    ERIC Educational Resources Information Center

    Kerr, Michelle Bailey

    2013-01-01

    The purpose of this study was to examine the impact that perceived administrative support and stress had on special education teachers' self-efficacy. A survey was used to gather quantitative data from 244 special education teachers in Central California's Tulare and Fresno counties. Using correlation and regression analysis, this study found a…

  5. Central Nervous Insulin Administration before Nocturnal Sleep Decreases Breakfast Intake in Healthy Young and Elderly Subjects

    PubMed Central

    Santiago, João C. P.; Hallschmid, Manfred

    2017-01-01

    Peripheral insulin acts on the brain to regulate metabolic functions, in particular decreasing food intake and body weight. This concept has been supported by studies in humans relying on the intranasal route of administration, a method that permits the direct permeation of insulin into the CNS without substantial absorption into the blood stream. We investigated if intranasal insulin administration before nocturnal sleep, a period of reduced metabolic activity and largely absent external stimulation, affects food intake and energy turnover on the subsequent morning. Healthy participants who were either young (16 men and 16 women; mean age ± SEM, 23.68 ± 0.40 years, mean BMI ± SEM, 22.83 ± 0.33 kg/m2) or elderly (10 men, 9 women; 70.79 ± 0.81 years, 25.27 ± 0.60 kg/m2) were intranasally administered intranasal insulin (160 IU) or placebo before a night of regular sleep that was polysomnographically recorded. Blood was repeatedly sampled for the determination of circulating glucose, insulin, leptin and total ghrelin. In the morning, energy expenditure was assessed via indirect calorimetry and subjects were offered a large standardized breakfast buffet from which they could eat ad libitum. Insulin compared to placebo reduced breakfast size by around 110 kcal (1,054.43 ± 50.91 vs. 1,162.36 ± 64.69 kcal, p = 0.0095), in particular decreasing carbohydrate intake (502.70 ± 25.97 vs. 589.82 ± 35.03 kcal, p = 0.0080). This effect was not dependent on sex or age (all p > 0.11). Sleep architecture, blood glucose and hormonal parameters as well as energy expenditure were not or only marginally affected. Results show that intranasal insulin administered to healthy young and elderly humans before sleep exerts a delayed inhibitory effect on energy intake that is not compensated for by changes in energy expenditure. While the exact underlying mechanisms cannot be derived from our data, findings indicate a long-lasting catabolic effect of central nervous insulin delivery

  6. Central Nervous Insulin Administration before Nocturnal Sleep Decreases Breakfast Intake in Healthy Young and Elderly Subjects.

    PubMed

    Santiago, João C P; Hallschmid, Manfred

    2017-01-01

    Peripheral insulin acts on the brain to regulate metabolic functions, in particular decreasing food intake and body weight. This concept has been supported by studies in humans relying on the intranasal route of administration, a method that permits the direct permeation of insulin into the CNS without substantial absorption into the blood stream. We investigated if intranasal insulin administration before nocturnal sleep, a period of reduced metabolic activity and largely absent external stimulation, affects food intake and energy turnover on the subsequent morning. Healthy participants who were either young (16 men and 16 women; mean age ± SEM, 23.68 ± 0.40 years, mean BMI ± SEM, 22.83 ± 0.33 kg/m(2)) or elderly (10 men, 9 women; 70.79 ± 0.81 years, 25.27 ± 0.60 kg/m(2)) were intranasally administered intranasal insulin (160 IU) or placebo before a night of regular sleep that was polysomnographically recorded. Blood was repeatedly sampled for the determination of circulating glucose, insulin, leptin and total ghrelin. In the morning, energy expenditure was assessed via indirect calorimetry and subjects were offered a large standardized breakfast buffet from which they could eat ad libitum. Insulin compared to placebo reduced breakfast size by around 110 kcal (1,054.43 ± 50.91 vs. 1,162.36 ± 64.69 kcal, p = 0.0095), in particular decreasing carbohydrate intake (502.70 ± 25.97 vs. 589.82 ± 35.03 kcal, p = 0.0080). This effect was not dependent on sex or age (all p > 0.11). Sleep architecture, blood glucose and hormonal parameters as well as energy expenditure were not or only marginally affected. Results show that intranasal insulin administered to healthy young and elderly humans before sleep exerts a delayed inhibitory effect on energy intake that is not compensated for by changes in energy expenditure. While the exact underlying mechanisms cannot be derived from our data, findings indicate a long-lasting catabolic effect of central nervous insulin

  7. A new perspective on the 1930s mega-heat waves across central United States

    NASA Astrophysics Data System (ADS)

    Cowan, Tim; Hegerl, Gabi

    2016-04-01

    The unprecedented hot and dry conditions that plagued contiguous United States during the 1930s caused widespread devastation for many local communities and severely dented the emerging economy. The heat extremes experienced during the aptly named Dust Bowl decade were not isolated incidences, but part of a tendency towards warm summers over the central United States in the early 1930s, and peaked in the boreal summer 1936. Using high-quality daily maximum and minimum temperature observations from more than 880 Global Historical Climate Network stations across the United States and southern Canada, we assess the record breaking heat waves in the 1930s Dust Bowl decade. A comparison is made to more recent heat waves that have occurred during the latter half of the 20th century (i.e., in a warming world), both averaged over selected years and across decades. We further test the ability of coupled climate models to simulate mega-heat waves (i.e. most extreme events) across the United States in a pre-industrial climate without the impact of any long-term anthropogenic warming. Well-established heat wave metrics based on the temperature percentile threshold exceedances over three or more consecutive days are used to describe variations in the frequency, duration, amplitude and timing of the events. Casual factors such as drought severity/soil moisture deficits in the lead up to the heat waves (interannual), as well as the concurrent synoptic conditions (interdiurnal) and variability in Pacific and Atlantic sea surface temperatures (decadal) are also investigated. Results suggest that while each heat wave summer in the 1930s exhibited quite unique characteristics in terms of their timing, duration, amplitude, and regional clustering, a common factor in the Dust Bowl decade was the high number of consecutive dry seasons, as measured by drought indicators such as the Palmer Drought Severity and Standardised Precipitation indices, that preceded the mega-heat waves. This

  8. Effects of oral administration of heat-killed Enterococcus faecium strain NHRD IHARA in post-weaning piglets.

    PubMed

    Sukegawa, Shin; Ihara, Yasuhiro; Yuge, Kaoruko; Rao, Shengbin; Oka, Kentaro; Arakawa, Fumihiro; Fujimura, Tatsuya; Murakami, Hiroshi; Kurazono, Hisao; Takahashi, Motomichi; Morimatsu, Fumiki

    2014-04-01

    Probiotic bacteria such as lactic acid bacteria (LAB) have recently received attention as candidates for alternative anti-microbial feed additives. We previously isolated Enterococcus faecium strain NHRD IHARA (FERM BP-11090, NHRD IHARA strain) and reported its probiotic efficacy. However, we have not determined the effect of oral administration of heat-killed cells of this strain. Here, we performed two experiments to investigate the effect of oral administration of the heat-killed NHRD IHARA strain on post-weaning piglets. In Experiment 1, there was a significant improvement in growth performance (P = 0.04) and increase in serum immunoglobulin A (IgA) production (P = 0.03) in the group fed heat-killed cells. These results were similar to previous results we obtained with live cells. We also found changes in serum and fecal IgA production that were unrelated to the patterns of microbiotal change. In Experiment 2, we detected a significant improvement in villus growth in the jejunum (P = 0.0002). In conclusion, oral administration of the heat-killed NHRD IHARA strain in post-weaning piglets had the same efficacy as administration of the live strain. The heat-killed NHRD IHARA strain can be used as feed additives to improve pig growth and health on commercial farms.

  9. Calibration of Discrete Element Heat Transfer Parameters by Central Composite Design

    NASA Astrophysics Data System (ADS)

    Deng, Zongquan; Cui, Jinsheng; Hou, Xuyan; Jiang, Shengyuan

    2017-03-01

    The efficiency and precision of parameter calibration in discrete element method (DEM) are not satisfactory, and parameter calibration for granular heat transfer is rarely involved. Accordingly, parameter calibration for granular heat transfer with the DEM is studied. The heat transfer in granular assemblies is simulated with DEM, and the effective thermal conductivity (ETC) of these granular assemblies is measured with the transient method in simulations. The measurement testbed is designed to test the ETC of the granular assemblies under normal pressure and a vacuum based on the steady method. Central composite design (CCD) is used to simulate the impact of the DEM parameters on the ETC of granular assemblies, and the heat transfer parameters are calibrated and compared with experimental data. The results show that, within the scope of the considered parameters, the ETC of the granular assemblies increases with an increasing particle thermal conductivity and decreases with an increasing particle shear modulus and particle diameter. The particle thermal conductivity has the greatest impact on the ETC of granular assemblies followed by the particle shear modulus and then the particle diameter. The calibration results show good agreement with the experimental results. The error is less than 4%, which is within a reasonable range for the scope of the CCD parameters. The proposed research provides high efficiency and high accuracy parameter calibration for granular heat transfer in DEM.

  10. Effect of volume loading on the Frank–Starling relation during reductions in central blood volume in heat-stressed humans

    PubMed Central

    Bundgaard-Nielsen, M; Wilson, T E; Seifert, T; Secher, N H; Crandall, C G

    2010-01-01

    During reductions in central blood volume while heat stressed, a greater decrease in stroke volume (SV) for a similar decrease in ventricular filling pressure, compared to normothermia, suggests that the heart is operating on a steeper portion of a Frank–Starling curve. If so, volume loading of heat-stressed individuals would shift the operating point to a flatter portion of the heat stress Frank–Starling curve thereby attenuating the reduction in SV during subsequent decreases in central blood volume. To investigate this hypothesis, right heart catheterization was performed in eight males from whom pulmonary capillary wedge pressure (PCWP), central venous pressure and SV (via thermodilution) were obtained while central blood volume was reduced via lower-body negative pressure (LBNP) during normothermia, whole-body heating (increase in blood temperature ∼1°C), and during whole-body heating after intravascular volume expansion. Volume expansion was accomplished by administration of a combination of a synthetic colloid (HES 130/0.4, Voluven) and saline. Before LBNP, SV was not affected by heating (122 ± 30 ml; mean ±s.d.) compared to normothermia (110 ± 20 ml; P= 0.06). However, subsequent volume loading increased SV to 143 ± 29 ml (P= 0.003). LBNP provoked a larger decrease in SV relative to the decrease in PCWP during heating (8.6 ± 1.9 ml mmHg−1) compared to normothermia (4.5 ± 3.0 ml mmHg−1, P= 0.02). After volume loading while heat stressed, the reduction in the SV to PCWP ratio during LBNP was comparable to that observed during normothermia (4.8 ± 2.3 ml mmHg−1; P= 0.78). These data support the hypothesis that a Frank–Starling mechanism contributes to compromised blood pressure control during simulated haemorrhage in heat-stressed individuals, and extend those findings by showing that volume infusion corrects this deficit by shifting the operating point to a flatter portion of the heat stress Frank–Starling curve. PMID:20603336

  11. Effect of volume loading on the Frank-Starling relation during reductions in central blood volume in heat-stressed humans.

    PubMed

    Bundgaard-Nielsen, M; Wilson, T E; Seifert, T; Secher, N H; Crandall, C G

    2010-09-01

    During reductions in central blood volume while heat stressed, a greater decrease in stroke volume (SV) for a similar decrease in ventricular filling pressure, compared to normothermia, suggests that the heart is operating on a steeper portion of a Frank-Starling curve. If so, volume loading of heat-stressed individuals would shift the operating point to a flatter portion of the heat stress Frank-Starling curve thereby attenuating the reduction in SV during subsequent decreases in central blood volume. To investigate this hypothesis, right heart catheterization was performed in eight males from whom pulmonary capillary wedge pressure (PCWP), central venous pressure and SV (via thermodilution) were obtained while central blood volume was reduced via lower-body negative pressure (LBNP) during normothermia, whole-body heating (increase in blood temperature 1 degrees C), and during whole-body heating after intravascular volume expansion. Volume expansion was accomplished by administration of a combination of a synthetic colloid (HES 130/0.4, Voluven) and saline. Before LBNP, SV was not affected by heating (122 +/- 30 ml; mean +/- s.d.) compared to normothermia (110 +/- 20 ml; P = 0.06). However, subsequent volume loading increased SV to 143 +/- 29 ml (P = 0.003). LBNP provoked a larger decrease in SV relative to the decrease in PCWP during heating (8.6 +/- 1.9 ml mmHg(1)) compared to normothermia (4.5 +/- 3.0 ml mmHg(1), P = 0.02). After volume loading while heat stressed, the reduction in the SV to PCWP ratio during LBNP was comparable to that observed during normothermia (4.8 +/- 2.3 ml mmHg(1); P = 0.78). These data support the hypothesis that a Frank-Starling mechanism contributes to compromised blood pressure control during simulated haemorrhage in heat-stressed individuals, and extend those findings by showing that volume infusion corrects this deficit by shifting the operating point to a flatter portion of the heat stress Frank-Starling curve.

  12. RESTful M2M Gateway for Remote Wireless Monitoring for District Central Heating Networks

    PubMed Central

    Cheng, Bo; Wei, Zesan

    2014-01-01

    In recent years, the increased interest in energy conservation and environmental protection, combined with the development of modern communication and computer technology, has resulted in the replacement of distributed heating by central heating in urban areas. This paper proposes a Representational State Transfer (REST) Machine-to-Machine (M2M) gateway for wireless remote monitoring for a district central heating network. In particular, we focus on the resource-oriented RESTful M2M gateway architecture, and present an uniform devices abstraction approach based on Open Service Gateway Initiative (OSGi) technology, and implement the resource mapping mechanism between resource address mapping mechanism between RESTful resources and the physical sensor devices, and present the buffer queue combined with polling method to implement the data scheduling and Quality of Service (QoS) guarantee, and also give the RESTful M2M gateway open service Application Programming Interface (API) set. The performance has been measured and analyzed. Finally, the conclusions and future work are presented. PMID:25436650

  13. RESTful M2M gateway for remote wireless monitoring for district central heating networks.

    PubMed

    Cheng, Bo; Wei, Zesan

    2014-11-27

    In recent years, the increased interest in energy conservation and environmental protection, combined with the development of modern communication and computer technology, has resulted in the replacement of distributed heating by central heating in urban areas. This paper proposes a Representational State Transfer (REST) Machine-to-Machine (M2M) gateway for wireless remote monitoring for a district central heating network. In particular, we focus on the resource-oriented RESTful M2M gateway architecture, and present an uniform devices abstraction approach based on Open Service Gateway Initiative (OSGi) technology, and implement the resource mapping mechanism between resource address mapping mechanism between RESTful resources and the physical sensor devices, and present the buffer queue combined with polling method to implement the data scheduling and Quality of Service (QoS) guarantee, and also give the RESTful M2M gateway open service Application Programming Interface (API) set. The performance has been measured and analyzed. Finally, the conclusions and future work are presented.

  14. Mapping regional distribution of land surface heat fluxes on the southern side of the central Himalayas using TESEBS

    NASA Astrophysics Data System (ADS)

    Amatya, Pukar Man; Ma, Yaoming; Han, Cunbo; Wang, Binbin; Devkota, Lochan Prasad

    2016-05-01

    Recent scientific studies based on large-scale climate model have highlighted the importance of the heat release from the southern side of the Himalayas for the development of South Asian Summer Monsoon. However, studies related to land surface heat fluxes are nonexistent on the southern side. In this study, we test the feasibility of deriving land surface heat fluxes on the central Himalayan region using Topographically Enhanced Surface Energy Balance System (TESEBS), which is forced by MODIS land surface products and Global Land Data Assimilation System (GLDAS) meteorological data. The model results were validated using the first eddy covariance measurement system established in the southern side of the central Himalayas. The derived land surface heat fluxes were close to the field measurements with mean bias of 15.97, -19.89, 8.79, and -20.39 W m-2 for net radiation flux, ground heat flux, sensible heat flux, and latent heat flux respectively. Land surface heat fluxes show strong contrast in pre monsoon, summer monsoon, post monsoon, and winter seasons and different land surface states among the different physiographic regions. In the central Himalayas, the latent heat flux is the dominant consumer of available energy for all physiographic regions except for the High Himalaya where the sensible heat flux is high.

  15. Development of a solar thermal central heat receiver using molten salt

    NASA Astrophysics Data System (ADS)

    Tracey, T. R.

    1981-06-01

    The development and test of a 5 MWth solar heat receiver using a molten nitrate salt (60 percent NaNO3, 40 percent KNaNO3) as the heat transfer fluid is described. The application of the receiver concept in a central receiver solar power system is explained. The advantages of using molten nitrate salts as the receiver heat transfer fluid and the storage fluid are discussed. The problems associated with the receiver development including the need for high temperatures and combinations of creep and fatigue in the receiver tubes are discussed. Our approach to scaling from the 5 MWth test receiver to commercial receivers in the range of 200 MWth to 500 MWth is defined. The 5 MWth test system is described including the instrumentation used. The test facility which has a 60 m tower and 222 heliostats is described. The test results are presented. The receiver was in test for 500 hr at temperature and heat flux levels expected in commercial receiver systems.

  16. Central Data Processing System (CDPS) user's manual: Solar heating and cooling program

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The software and data base management system required to assess the performance of solar heating and cooling systems installed at multiple sites is presented. The instrumentation data associated with these systems is collected, processed, and presented in a form which supported continuity of performance evaluation across all applications. The CDPS consisted of three major elements: communication interface computer, central data processing computer, and performance evaluation data base. Users of the performance data base were identified, and procedures for operation, and guidelines for software maintenance were outlined. The manual also defined the output capabilities of the CDPS in support of external users of the system.

  17. Effect of long-term administration of zinc after scrotal heating on mice spermatozoa and subsequent offspring quality.

    PubMed

    Ghasemi, N; Babaei, H; Azizallahi, S; Kheradmand, A

    2009-08-01

    This study was set to investigate whether the adverse effects of heat on spermatozoa and subsequent foetuses could be prevented by long-term zinc administration. The scrotums of animals were immersed in water at either 43 degrees C (heat group) or 23 degrees C (control group). Half of the heat and control mice were given 10 mg kg(-1) zinc every other day for 60 days and the others received sterile saline instead of zinc. Heat stress significantly reduced sperm motility, concentration, hypoosmotic swelling-water test (HOS-WT) positive and chromomycin A(3) (CMA(3)) negative spermatozoa at the first 15 days, and the greatest decrease occurred at 30 days (P < 0.05). Sperm motility, concentration and HOS-WT positive spermatozoa were also reduced initially in the zinc administered group, but we did not observe any further decrease in the above mentioned parameters on day 30 (P < 0.05). The weight of foetuses obtained from the females mated with paternal heat treatment males was significantly lower than that of the control group (P < 0.05) and long-term zinc therapy caused a partial recovery (P > 0.05). This study demonstrates that the adverse effects of hyperthermia on semen parameters may be prevented by zinc therapy. Likewise, long-term administration of zinc could improve quality of litter obtained from the females mated with scrotal heat treatment males.

  18. Feedback quality and environmentally friendly use of domestic central heating systems.

    PubMed

    Sauer, J; Schmeink, C; Wastell, D G

    2007-06-01

    The study examined the influence of system-embedded feedback on user behaviour during the environmentally friendly operation of a central heating system. A PC-based simulation, called CHESS, was developed to model the critical features of a central heating system. After having received 30 min of training on the simulation task, 60 participants worked on a series of operational scenarios under different levels of system feedback. In addition to the collection of various performance measures (e.g. energy consumption, energy wastage), a range of user variables was collected (e.g. environmental concern). As hypothesized, the results showed that increased feedback resulted in improved environmentally friendly performance and, more importantly, the specific feedback indicator influenced the type of strategy used to improve human - machine system performance. A major implication is that system designers need to develop feedback indicators that are chiefly influenced by user behaviour and are largely immune to factors that are beyond the user's control (e.g. weather conditions).

  19. Peripheral markers of central fatigue in trained and untrained during uncompensable heat stress.

    PubMed

    Wright, Heather E; Selkirk, Glen A; Rhind, Shawn G; McLellan, Tom M

    2012-03-01

    The development of fatigue is more pronounced in the heat than thermoneutral environments; however, it is unclear whether biomarkers of central fatigue are consistent with the higher core temperature (T (c)) tolerated by endurance trained (TR) versus untrained (UT) during exertional heat stress (EHS). The purpose of this study was to examine the indicators of central fatigue during EHS in TR versus UT. Twelve TR and 11 UT males (mean ± SE [Formula: see text] = 70 ± 2 and 50 ± 1 mL kg LBM(-1) min(-1), respectively) walked on a treadmill to exhaustion (EXH) in 40°C (dry) wearing protective clothing. Venous blood was obtained at PRE and 0.5°C T (c) increments from 38 to 40°C/EXH. Free tryptophan (f-TRP) decreased dramatically at 39.5°C for the TR. Branch chain amino acids decreased with T (c) and were greater for UT than TR at EXH. Tyrosine and phenylalanine remained unchanged. Serum S100β was undetectable (<5 pg mL(-1)). Albumin was greater for the UT from PRE to 39.0°C and at EXH. Prolactin (PRL) responded to relative thermal strain with similar EXH values despite higher T (c) tolerated for TR (39.7 ± 0.09°C) than UT (39.0 ± 0.09°C). The high EXH PRL values for both groups support its use as a biomarker of the serotonin and dopamine interplay within the brain during the development of central fatigue.

  20. Anomalous subglacial heat flow in central Greenland induced by the Iceland plume.

    NASA Astrophysics Data System (ADS)

    Petrunin, Alexey G.; Rogozhina, Irina; Kaban, Mikhail K.; Vaughan, Alan P. M.; Steinberger, Bernhard; Johnson, Jesse; Koulakov, Ivan; Thomas, Maik

    2013-04-01

    3000 m of ice sheet thickness has ensured that central Greenland has kept it geothermal heat flow (GHF) distribution enigmatic. Some few direct ice temperature measurements from deep ice cores reveal a GHF of 50 to 60 mW/m² in the Summit region and this is noticeably above what would be expected for the underlying Early Proterozoic lithosphere. In addition, indirect estimates from zones of rapid basal melting suggest extreme anomalies 15 to 30 times continental background. Subglacial topography indicates caldera like topographic features in the zones hinting at possible volcanic activity in the past [1], and all of these observations combined hint at an anomalous lithospheric structure. Further supporting this comes from new high-resolution P-wave tomography, which shows a strong thermal anomaly in the lithosphere crossing Greenland from east to west [2]. Rock outcrops at the eastern and western end of this zone indicate significant former magmatic activity, older in the east and younger in the west. Additionally, plate modelling studies suggest that the Greenland plate passed over the mantle plume that is currently under Iceland from late Cretaceous to Neogene times, consistent with the evidence from age of magmatism. Evidence of rapid basal melt revealed by ice penetrating radar along the hypocentre of the putative plume track indicates that it continues to affect the Greenland continental geotherm today. We analyse plume-induced thermal disturbance of the present-day lithosphere and their effects on the central Greenland ice sheet by using a novel evolutionary model of the climate-ice-lithosphere-upper mantle system. Our results indicate that mantle plume-induced erosion of the lithosphere has occurred, explaining caldera-type volcanic structures, the GHF anomaly, and requiring dyke intrusion into the crust during the early Cenozoic. The residual thermo-mechanical effect of the mantle plume has raised deep-sourced heat flow by over 25 mW/m² since 60 Ma and

  1. Serving Six Institutions: A History of Administrative Computing at the Associated Colleges of Central Kansas.

    ERIC Educational Resources Information Center

    Brown, Ray; Doughty, Gavin; McDowell, Valerie

    This paper offers a brief history and description of a voluntary consortium of six church-related private colleges, the Associated Colleges of Central Kansas (ACCK), that is governed by a board of directors made up of the presidents of the member colleges. The schools, all within close geographical proximity, have a combined enrollment of over…

  2. Value impact assessment: A preliminary assessment of improvement opportunities at the Quantico Central Heating Plant

    SciTech Connect

    Brambley, M.R.; Weakley, S.A.

    1990-09-01

    This report presents the results of a preliminary assessment of opportunities for improvement at the US Marine Corps (USMC) Quantico, Virginia, Central Heating Plant (CHP). This study is part of a program intended to provide the CHP staff with a computerized Artificial Intelligence (AI) decision support system that will assist in a more efficient, reliable, and safe operation of their plant. As part of the effort to provide the AI decision support system, a team of six scientists and engineers from the Pacific Northwest Laboratory (PNL) visited the plant to characterize the conditions and environment of the CHP. This assessment resulted in a list of potential performance improvement opportunities at the CHP. In this report, 12 of these opportunities are discussed and qualitatively analyzed. 70 refs., 7 figs., 6 tabs.

  3. Activation of noradrenergic neurons projecting to the diencephalon following central administration of histamine is mediated by H1 receptors.

    PubMed

    Fleckenstein, A E; Lookingland, K J; Moore, K E

    1994-02-28

    The effect of histamine on the activity of noradrenergic neurons terminating in discrete regions of the diencephalon was examined in male rats. Noradrenergic neuronal activity was estimated by measuring the concentration of norepinephrine and its metabolite 3-methoxy-4-hydroxyphenylethyleneglycol [MHPG] in the medial zona incerta [MZI] and in the dorsomedial [DMN], periventricular [PeVN] and medial preoptic hypothalamic nuclei [MPN]. The intracerebroventricular administration of histamine effected a time-related increase in MHPG concentrations in the MZI, DMN, PeVN and MPN; these effects were blocked by the H1 antagonist mepyramine but not the H2 antagonist zolantidine. Neither mepyramine nor zolantidine affected basal MHPG concentrations in any of the brain regions examined. These results indicate that central administration of histamine increases the activity of noradrenergic neurons projecting to the diencephalon via an action at H1 but not H2 receptors.

  4. Increased occupational coal dust toxicity in blood of central heating system workers.

    PubMed

    Tuluce, Yasin; Ozkol, Halil; Koyuncu, Ismail; Ine, Hatice

    2011-02-01

    Coal dust causes lung diseases in occupational exposure. Reactive oxygen species have been implicated in the pathogenesis of its toxicity. In this study, serum enzymes, lipid profile and other biochemical values with oxidant/antioxidant status in whole blood and serum of central heating system workers (CHSW; the persons responsible for heating the apartment with coal) were determined to reflect the cell injury. Blood samples were obtained from CHSW (n = 25) and healthy individuals (n = 25). All values were measured in whole blood and serum. ANOVA was used for the estimation of statistical data. In the group of CHSW, creatinine, ferritin, alanin aminotransferase, aspartate aminotransferase, creatine phosphokinase, gamma glutamyl transferase, lactate dehydrogenase and glutathione reductase activities as well as triglyceride, very low density lipoprotein, protein carbonyl and malondialdehide were significantly higher, while transferrin, high density lipoprotein and catalase (CAT) activities were lower than the group of healthy individuals. This result is consistent with hypothesis that respirable coal dust generates lipid and protein oxidation and induces leakage of serum enzymes by cell damage. It also leads to imbalance in antioxidant defense system, lipid profile and other biochemical parameters.

  5. A critical evaluation of semianalytic methods in the study of centrally heated, unresolved, infrared sources

    NASA Technical Reports Server (NTRS)

    Doty, Steven D.; Leung, Chun Ming

    1994-01-01

    We critically evaluate current methods of analysis in infrared (IR) astronomy and investigate the conditions under which these semianalytic methods are reliable. Specifically we examine the usual assumptions of homogeneities in dust density and temperature, and neglect of opacity effects when applied to internally heated, unresolved IR sources. To accomplish this, a series of radiation transport models for these sources have been constructed. The model results are treated as observed quantities and analyzed to derive the source parameters, using simple semianalytic methods. The discrepancies between the derived and actual model parameters can then be attributed to the limitations of the analysis methods and provide a measure of their reliability. Applying this approach to centrally heated, unresolved IR sources, we have studied in detail the following diagnostic problems: (1) determination of dust mass from monochromatic and integrated luminosities; (2) estimation of dust temperature distribution from color temperatures derived from the flux spectrum; and (3) determination of the empirical grain emissivity law (opacity function) for both continuum and spectral features.

  6. Effect of passive whole body heating on central conduction and cortical excitability in multiple sclerosis patients and healthy controls.

    PubMed

    White, Andrea T; Vanhaitsma, Timothy A; Vener, Jamie; Davis, Scott L

    2013-06-15

    Heat stress is associated with increased fatigue perception and decrements in function for individuals with multiple sclerosis (MS). Similarly, healthy individuals experience decrements in exercise performance during hyperthermia. Alterations in central nervous system (CNS) function during hyperthermia include reduced voluntary activation of muscle and increased effort perception. The purpose of this investigation was to test the hypothesis that passive heat exposure in MS patients will produce increased subjective fatigue and impairments in physiological measures of central conduction and cortical excitability compared with healthy individuals. Eleven healthy individuals and 11 MS patients completed a series of transcranial magnetic stimulation studies to examine central conduction and cortical excitability under thermoneutral and heat-stressed (HS) conditions at rest and after a fatiguing thumb abduction task. Passive heat stress resulted in significantly greater fatigue perception and impairments in force production in MS patients. Central motor conduction time was significantly shorter during HS in controls; however, in MS patients normal increases in conduction velocity with increased temperature were not observed centrally. MS patients also exhibited decreased cortical excitability during HS, evidenced by significant increases in resting motor threshold, decreased MEP amplitude, and decreased recruitment curve slope. Both groups exhibited postexercise depression of MEP amplitude, but the magnitude of these decrements was amplified in MS patients during HS. Taken together, these results suggest that CNS pathology in MS patients played a substantial role in reducing cortical excitability during HS.

  7. Record-breaking 2015 heat waves in Central Europe: how to view them in the climate change context?

    NASA Astrophysics Data System (ADS)

    Lhotka, Ondrej; Plavcová, Eva; Kyselý, Jan

    2016-04-01

    The 2015 summer was the warmest summer ever observed in Central Europe according to many characteristics, including the overall severity of heat waves. We assess how unusual this summer was by i) comparing the seasonal temperature anomalies and severity of heat waves against long-term temperature records at Central European stations, ii) evaluating its temperature characteristics at the continental scale against hot summers and major heat waves affecting Europe recently (including the 2003 western-European heat waves and the 2010 Russian heat waves), and iii) identifying time slices in climate change scenarios for the 21st century in which similar events are projected to occur over Central Europe at least once per decade. In the last point, we make use of a large ensemble of RCM simulations from CORDEX and ENSEMBLES projects and critically evaluate their ability to simulate events such as the 2015 summer (in terms of both seasonal temperature anomalies and heat waves, including their spatial extent). We examine also how results for the climate change scenarios depend on radiative forcing and driving global models.

  8. Central administration of chicken growth hormone-releasing hormone decreases food intake in chicks.

    PubMed

    Tachibana, Tetsuya; Sugimoto, Ikue; Ogino, Madoka; Khan, Md Sakirul Islam; Masuda, Keiko; Ukena, Kazuyoshi; Wang, Yajun

    2015-02-01

    Growth hormone-releasing hormone (GHRH) is well known as a stimulator of growth hormone (GH) secretion. GHRH not only stimulates GH release but also modifies feeding behavior and energy homeostasis in rodents. In chickens (Gallus gallus domesticus), on the other hand, two types of GHRH, namely, chicken GHRH (cGHRH) and cGHRH-like peptide (cGHRH-LP), have been identified. The purpose of the present study was to investigate the effect of central injection of cGHRH and cGHRH-LP on feeding behavior in chicks. Intracerebroventricular (ICV) injection of both cGHRH and cGHRH-LP (0.04 to 1 nmol) significantly decreased food intake without any abnormal behavior in chicks. Furthermore, the feeding-inhibitory effect was not abolished by co-injection of the antagonist for pituitary adenylate cyclase-activating polypeptide (PACAP) or corticotropin-releasing hormone (CRH) receptors, suggesting that the anorexigenic effect of cGHRH and cGHRH-LP might not be related to the PACAP and CRH systems in the brain of chicks. Finally, 24-h food deprivation increased mRNA expression of cGHRH but not cGHRH-LP in the diencephalon. These results suggest that central cGHRH is related to inhibiting feeding behavior and energy homeostasis in chicks.

  9. Central administration of metastin increases food intake through opioid neurons in chicks.

    PubMed

    Khan, Md Sakirul Islam; Ohkubo, Takeshi; Masuda, Naoto; Tachibana, Tetsuya; Ueda, Hiroshi

    2009-06-01

    Metastin, an RFamide peptide, has been isolated from human placenta and possesses several physiological actions in mammals. However, little is known about this bioactive peptide in avian species. This study was conducted to assess the effect of metastin on feeding behavior of chicks (Gallus gallus). The food intake of chicks is significantly increased by the intracerebroventricular injection of metastin. Beta-funaltrexamine, a mu-opioid receptor antagonist, significantly attenuates metastin-induced food intake in chicks. In contrast, delta- and kappa-opioid receptor antagonists did not show any influence on metastin-induced food intake in chicks. In addition, administration of N(G)-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, did not influence metastin-induced food intake. Taken together, this study shows the orexigenic effect of metastin in chicks and suggests that this effect is mediated by mu-opioid receptor.

  10. Central administration of angiotensin IV rapidly enhances novel object recognition among mice.

    PubMed

    Paris, Jason J; Eans, Shainnel O; Mizrachi, Elisa; Reilley, Kate J; Ganno, Michelle L; McLaughlin, Jay P

    2013-07-01

    Angiotensin IV (Val(1)-Tyr(2)-Ile(3)-His(4)-Pro(5)-Phe(6)) has demonstrated potential cognitive-enhancing effects. The present investigation assessed and characterized: (1) dose-dependency of angiotensin IV's cognitive enhancement in a C57BL/6J mouse model of novel object recognition, (2) the time-course for these effects, (3) the identity of residues in the hexapeptide important to these effects and (4) the necessity of actions at angiotensin IV receptors for procognitive activity. Assessment of C57BL/6J mice in a novel object recognition task demonstrated that prior administration of angiotensin IV (0.1, 1.0, or 10.0, but not 0.01 nmol, i.c.v.) significantly enhanced novel object recognition in a dose-dependent manner. These effects were time dependent, with improved novel object recognition observed when angiotensin IV (0.1 nmol, i.c.v.) was administered 10 or 20, but not 30 min prior to the onset of the novel object recognition testing. An alanine scan of the angiotensin IV peptide revealed that replacement of the Val(1), Ile(3), His(4), or Phe(6) residues with Ala attenuated peptide-induced improvements in novel object recognition, whereas Tyr(2) or Pro(5) replacement did not significantly affect performance. Administration of the angiotensin IV receptor antagonist, divalinal-Ang IV (20 nmol, i.c.v.), reduced (but did not abolish) novel object recognition; however, this antagonist completely blocked the procognitive effects of angiotensin IV (0.1 nmol, i.c.v.) in this task. Rotorod testing demonstrated no locomotor effects with any angiotensin IV or divalinal-Ang IV dose tested. These data demonstrate that angiotensin IV produces a rapid enhancement of associative learning and memory performance in a mouse model that was dependent on the angiotensin IV receptor.

  11. Land surface and atmospheric conditions associated with heat waves over the Chickasaw Nation in the South Central United States

    NASA Astrophysics Data System (ADS)

    Lee, Eungul; Bieda, Rahama; Shanmugasundaram, Jothiganesh; Basara Richter, Heather

    2016-06-01

    Exposure to extreme heat was reconstructed based on regional land-atmosphere processes from 1979 to 2010 in the South Central U.S. The study region surrounds the Chickasaw Nation (CN), a predominantly Native American population with a highly prevalent burden of climate-sensitive chronic diseases. Land surface and atmospheric conditions for summer heat waves were analyzed during spring (March-April-May, MAM) and summer (June-July-August, JJA) based on the Climate and Ocean: Variability, Predictability, and Change maximum temperature definition for heat wave frequency (HWF). The spatial-temporal pattern of HWF was determined using empirical orthogonal function (EOF) analysis and the corresponding principle component time series of the first EOF of HWF. Statistically significant analyses of observed conditions indicated that sensible heat increased and latent heat fluxes decreased with high HWF in the South Central U.S. The largest positive correlations of sensible heat flux to HWF and the largest negative correlations of latent heat flux to HWF were specifically observed over the CN. This is a significantly different energy transfer regime due to less available soil moisture during the antecedent MAM and JJA. The higher sensible heat from dry soil could cause significant warming from the near surface (>2.0°C) to the lower troposphere (>1.5°C), and accumulated boundary layer heat could induce the significant patterns of higher geopotential height and enhance anticyclonic circulations (negative vorticity anomaly) at the midtroposphere. Results suggested a positive land-atmosphere feedback associated with heat waves and called attention to the need for region-specific climate adaptation planning.

  12. Heat flow and subsurface temperature distributions in central and western New York. Final report

    SciTech Connect

    Hodge, D.S.; Fromm, K.

    1984-01-01

    Initiation of a geothermal energy program in western and central New York requires knowledge of subsurface temperatures for targeting areas of potential resources. The temperature distribution in possible geothermal reservoirs, calculated from heat flow measurements and modeling techniques, shows that a large area of New York can be considered for exploitation of geothermal resources. Though the temperatures at currently accessible depths show the availability of only a low-temperature (less than 100/sup 0/C), direct-use resource, this can be considered as an alternative for the future energy needs of New York State. From analysis of bottom-hole-temperature data and direct heat flow measurements, estimates of temperatures in the Cambrian Sandstones provide the basis of the economic evaluation of the reservoir. This reservoir contains the extractable fluids needed for targeting a potential geothermal well site in the low-temperature geothermal target zone. In the northern section of the Appalachian basin, reservoir temperatures in the Cambrian are below 50/sup 0/C but may be over 80/sup 0/C in the deeper parts of the basin in southern New York State. Using a minimum of 50/sup 0/C as a useful reservoir temperature, temperatures in excess of this value are encountered in the Theresa Formation at depths in excess of 1300 meters. Considering a maximum depth for economical drilling to be 2500 meters with present technology, the 2500 meters to the Theresa (sea level datum) forms the lower limit of the geothermal resource. Temperatures in the range of 70/sup 0/C to 80/sup 0/C are predicted for the southern portion of New York State.

  13. Dense gas in the Galactic central molecular zone is warm and heated by turbulence

    NASA Astrophysics Data System (ADS)

    Ginsburg, Adam; Henkel, Christian; Ao, Yiping; Riquelme, Denise; Kauffmann, Jens; Pillai, Thushara; Mills, Elisabeth A. C.; Requena-Torres, Miguel A.; Immer, Katharina; Testi, Leonardo; Ott, Juergen; Bally, John; Battersby, Cara; Darling, Jeremy; Aalto, Susanne; Stanke, Thomas; Kendrew, Sarah; Kruijssen, J. M. Diederik; Longmore, Steven; Dale, James; Guesten, Rolf; Menten, Karl M.

    2016-02-01

    Context. The Galactic center is the closest region where we can study star formation under extreme physical conditions like those in high-redshift galaxies. Aims: We measure the temperature of the dense gas in the central molecular zone (CMZ) and examine what drives it. Methods: We mapped the inner 300 pc of the CMZ in the temperature-sensitive J = 3-2 para-formaldehyde (p - H2CO) transitions. We used the 32,1-22,0/ 30,3-20,2 line ratio to determine the gas temperature in n ~ 104-105 cm-3 gas. We have produced temperature maps and cubes with 30'' and 1 km s-1 resolution and published all data in FITS form. Results: Dense gas temperatures in the Galactic center range from ~60 K to >100 K in selected regions. The highest gas temperatures TG> 100 K are observed around the Sgr B2 cores, in the extended Sgr B2 cloud, the 20 km s-1 and 50 km s-1 clouds, and in "The Brick" (G0.253+0.016). We infer an upper limit on the cosmic ray ionization rate ζCR< 10-14s-1. Conclusions: The dense molecular gas temperature of the region around our Galactic center is similar to values found in the central regions of other galaxies, in particular starburst systems. The gas temperature is uniformly higher than the dust temperature, confirming that dust is a coolant in the dense gas. Turbulent heating can readily explain the observed temperatures given the observed line widths. Cosmic rays cannot explain the observed variation in gas temperatures, so CMZ dense gas temperatures are not dominated by cosmic ray heating. The gas temperatures previously observed to be high in the inner ~75 pc are confirmed to be high in the entire CMZ. The data can be accessed from doi:10.7910/DVN/27601 and are available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/586/A50

  14. A Comparison of the Perceptions of School Work Culture by Administrators and Faculty in the Public Charter and Non-Charter Elementary Schools of a Central Florida County

    ERIC Educational Resources Information Center

    Quin, Wayne Anthony

    2012-01-01

    This study investigated perceptions of school work culture of instructional staff members (administrators and faculty) in public charter and public non-charter elementary schools in a large urban metropolitan county of Central Florida by assessing differences in perceptions of administrators and faculty related to school work culture, perceptions…

  15. Effects of human opiorphin on food intake and water intake in mice following central administration.

    PubMed

    Chen, Yong; Tian, Xiao-Zhu; Bai, Lu; Liu, Ze-Qi; Xiao, Xing-Peng; Liu, Pu; Li, Xiang-Kai

    2017-02-22

    Human opiorphin plays an important pharmacological functions in rats or mice. The present study was performed to investigate effects and underlying mechanism of central injected opiorphin on food intake and water intake in mice. Intracerebroventricularly (i.c.v.) administered opiorphin (5-20μg/kg) dose-dependently suppressed food intake in fasted mice, but had no influence on food intake in freely feeding mice. The cumulative food intake was significantly decreased at 60min after injection of 10 and 20μg/kg opiorphin and the food intake was significantly reduced during the 20-60min period after treatment. Non-selected opiate receptor antagonist naloxone could fully block the inhibitory effect induced by opiorphin on cumulative food intake at 60min in fasted mice, suggesting that the anorexic effect of opiorphin was related to the opioid system. Moreover, the anorexic effect induced by opiorphin in fasted mice was also significantly inhibited by pretreatment with captopril or valsartan, which suggested that endogenous angiotensin may be involved in the response to opiorphin. Interestingly, the effect of opiorphin on water intake was increased in both fasted and freely feeding mice, which was completely blocked by captopril and valsartan. Furthermore, naloxone did not modify the effect of opiorphin on water intake. All together, the food and water intake effects of opiorphin may be due to the protection of the endogenous angiotensin and opioid peptides from degradation by NEP or APN.

  16. Central administration of methamphetamine synergizes with metabolic inhibition to deplete striatal monoamines.

    PubMed

    Burrows, K B; Nixdorf, W L; Yamamoto, B K

    2000-03-01

    These studies examined, in vivo, the effect of local intrastriatal perfusion of methamphetamine (MA) on dopamine (DA) and glutamate release in relation to changes in striatal DA and serotonin (5-HT) content measured 1 week after treatment. Interactions between the inhibition of energy metabolism and the direct perfusion of MA on long-term decreases in DA and 5-HT content also were investigated. MA (100 microM), the succinate dehydrogenase inhibitor malonate, or the combination of MA and malonate was reverse-dialyzed into the striatum for 8 h. The continuous local perfusion of MA alone increased DA release by 30-fold, similar to that seen after systemic administration, but did not increase glutamate or body temperature, and did not deplete neurotransmitter content. Malonate perfusion increased both DA and glutamate overflow, and dose dependently decreased DA content. 5-HT content was not as affected by malonate perfusions (200 mM malonate depleted DA by 66% and 5-HT by 40%). When MA was coperfused with 200 mM malonate, DA content was reduced by 80% and to a greater extent compared with malonate alone. Coperfusion of MA and 200 mM malonate did not enhance 5-HT loss. Overall, the present findings provide evidence that energy metabolism plays an important role in MA toxicity and that striatal dopaminergic terminals are more vulnerable than 5-HT terminals to damage after metabolic stress.

  17. Acute Effect of Central Administration of Urotensin II on Baroreflex and Blood Pressure in Conscious Normotensive Rabbits

    PubMed Central

    Lim, Kyungjoon; Sata, Yusuke; Jackson, Kristy L.; Burke, Sandra L.; Head, Geoffrey A.

    2017-01-01

    In the present study, we examined the effects of central administration of Urotensin II on blood pressure, heart rate, and baroreceptor heart rate reflexes in conscious normotensive rabbits. Preliminary operations were undertaken to implant a balloon cuff on the inferior vena cava for baroreflex assessments and to implant cannula into the lateral and fourth ventricle. After 2 weeks of recovery cumulative dose response curves to Urotensin II (10, 100 ng, 1, 10, and 100 μg) given into the ventricles, or Ringer's solution as a vehicle were performed on separate days. Injections were given each hour and baroreflex assessments were made 30 min after each administration. Analysis of the dose response curves to Urotensin II compared to vehicle administered into the lateral or fourth ventricle, indicated little change to blood pressure or heart rate. Analysis of the time course to the highest dose over a 30 min period revealed a small (−5 mmHg) depressor response maximal at 10 min when injected into the fourth ventricle but no effect when injected into the lateral ventricle. Baroreflex assessments made at each dose showed that there was no change in baroreflex sensitivity but that an increase in the upper plateau was observed when Urotensin was injected into the lateral ventricle and a tendency for a reduced lower heart rate plateau was observed after fourth ventricle administration. Clonidine administration in the fourth ventricle decreased blood pressure and heart rate, thus confirming catheter patency. In conclusion, our findings suggest that Urotensin II in the forebrain and brainstem may play a role in modulating cardiac sympathetic and vagal baroreflexes but only during large acute changes in blood pressure. PMID:28280470

  18. Central neuropeptide B administration activates stress hormone secretion and stimulates feeding in male rats.

    PubMed

    Samson, W K; Baker, J R; Samson, C K; Samson, H W; Taylor, M M

    2004-10-01

    Neuropeptide B (NPB) was identified to be an endogenous, peptide ligand for the orphan receptors GPR7 and GPR8. Because GPR7 is expressed in rat brain and, in particular, in the hypothalamus, we hypothesized that NPB might interact with neuroendocrine systems that control hormone release from the anterior pituitary gland. No significant effects of NPB were observed on the in vitro releases of prolactin, adrenocorticotropic hormone (ACTH) or growth hormone (GH) when log molar concentrations ranging from 1 pM to 100 nM NPB were incubated with dispersed anterior pituitary cells harvested from male rats. In addition NPB (100 nM) did not alter the concentration response stimulation of prolactin secretion by thyrotropin-releasing hormone, ACTH secretion by corticotropin-releasing factor (CRF) and GH secretion by GH-releasing hormone. However, NPB, when injected into the lateral cerebroventricle (i.c.v.) of conscious, unrestrained male rats, elevated prolactin and corticosterone, and lowered GH levels in circulation. The threshold dose for the effect on corticosterone and prolactin levels was 1.0 nmol, while that for the effect on GH release was 3.0 nmol NPB. Pretreatment with a polyclonal anti-CRF antiserum completely blocked the ability of NPB to stimulate ACTH release and significantly inhibited the effect of NPB on plasma corticosterone levels. NPB administration i.c.v. did not significantly alter plasma vasopressin and oxytocin levels in conscious rats. It did stimulate feeding (minimum effective dose 1.0 nmol) in sated animals in a manner similar to that of the other endogenous ligand for GPR7, neuropeptide W. We conclude that NPB can act in the brain to modulate neuroendocrine signals accessing the anterior pituitary gland, but does not itself act as a releasing or inhibiting factor in the gland, at least with regard to prolactin, ACTH and GH secretion.

  19. Recent trends (2003-2013) of land surface heat fluxes on the southern side of the central Himalayas, Nepal

    NASA Astrophysics Data System (ADS)

    Amatya, Pukar Man; Ma, Yaoming; Han, Cunbo; Wang, Binbin; Devkota, Lochan Prasad

    2015-12-01

    Novice efforts have been made in order to study the regional distribution of land surface heat fluxes on the southern side of the central Himalayas utilizing high-resolution remotely sensed products, but these have been on instantaneous scale. In this study the Surface Energy Balance System model is used to obtain annual averaged maps of the land surface heat fluxes for 11 years (2003-2013) and study their annual trends on the central Himalayan region. The maps were derived at 5 km resolution using monthly input products ranging from satellite derived to Global Land Data Assimilation System meteorological data. It was found that the net radiation flux is increasing as a result of decreasing precipitation (drier environment). The sensible heat flux did not change much except for the northwestern High Himalaya and High Mountains. In northwestern High Himalaya sensible heat flux is decreasing because of decrease in wind speed, ground-air temperature difference, and increase in winter precipitation, whereas in High Mountains it is increasing due to increase in ground-air temperature difference and high rate of deforestation. The latent heat flux has an overall increasing trend with increase more pronounced in the lower regions compared to high elevated regions. It has been reported that precipitation is decreasing with altitude in this region. Therefore, the increasing trend in latent heat flux can be attributed to increase in net radiation flux under persistent forest cover and irrigation land used for agriculture.

  20. Heat Shock Proteins: Old and Novel Roles in Neurodegenerative Diseases in the Central Nervous System.

    PubMed

    van Noort, Johannes M; Bugiani, Marianna; Amor, Sandra

    2016-10-31

    Heat shock proteins (HSPs) are families of molecular chaperones that play important homeostatic functions in the central nervous system (CNS) by preventing protein misfolding, promoting degradation of improperly folded proteins, and protecting against apoptosis and inflammatory damage especially during hyperthermia, hypoxia, or oxidative stress. Under stress conditions, HSPs are upregulated to protect cells from damage that accumulates during ageing as well as pathological conditions. An important, yet frequently overlooked function of some HSPs is their ability to function as extracellular messengers (also termed chaperokines) that modulate immune responses within the CNS. Given the strong association between protein aggregation, innate immune cell activation and neurodegeneration, the expression and roles of HSPs in the CNS is attracting attention in many neurodegenerative disorders including inflammatory diseases such as multiple sclerosis, protein folding diseases such as Alzheimer's disease and amyotrophic lateral sclerosis, and genetic white matter diseases. This is especially so since several studies show that HSPs act therapeutically by modulating innate immune activation and may thus serve as neuroprotective agents. Here we review the evidence linking HSPs with neurodegenerative disorders in humans and the experimental animal models of these disorders. We discuss the mechanisms by which HSP protect cells, and how the knowledge of their endogenous functions can be exploited to treat disorders of the CNS.

  1. Experimental pneumococcal meningitis causes central nervous system pathology without inducing the 72-kd heat shock protein.

    PubMed Central

    Täuber, M. G.; Kennedy, S. L.; Tureen, J. H.; Lowenstein, D. H.

    1992-01-01

    We examined whether experimental pneumococcal meningitis induced the 72-kd heat shock protein (HSP72), a sensitive marker of neuronal stress in other models of central nervous system (CNS) injury. Brain injury was characterized by vasculitis, cerebritis, and abscess formation in the cortex of infected animals. The extent of these changes correlated with the size of the inoculum (P less than 0.003) and with pathophysiologic parameters of disease severity, i.e., cerebrospinal fluid (CSF) lactate (r = 0.61, P less than 0.0001) and CSF glucose concentrations (r = -0.55, P less than 0.0001). Despite the presence of numerous cortical regions having morphologic evidence of injury, HSP72 was not detected in most animals. When present, only rare neurons were HSP72 positive. Western blot analysis of brain samples confirmed the paucity of HSP72 induction. The lack of neuronal HSP72 expression in this model suggests that at least some of the events leading to neuronal injury in meningitis are unique, when compared with CNS diseases associated with HSP72 induction. Images Figure 1 Figure 2 Figure 3 PMID:1632471

  2. Domestic central heating radiators: a cause for concern in all age groups.

    PubMed

    Harper, R D; Dickson, W A

    1996-05-01

    A retrospective analysis of all burns admitted to the Welsh Regional Burns and Plastic Surgery Unit, Chepstow, in the period 1 January 1990 to 1 October 1993, highlighted a group of 50 patients who had sustained contact burns from the radiators of domestic central heating systems. There was a male prevalence, with an average age of 43.4 years (range 6 months to 100 years). The mean TBSA burned was 1.58 per cent (range 0.13-6.0 per cent) and half of the injuries were full thickness depth. The forearm and hand were predominantly injured. Although the literature has indicated that the incidence of contact burns peaks at the extremes of the age spectrum, this study has shown that contact radiator burns can be sustained by all age groups. The aim of the audit was to investigate the mechanism of injury and link precipitating factors. The contribution of the high surface temperature of the radiator to the burn injury is alluded to. The various methods available to reduce this risk are discussed and the use of the low surface temperature radiator, already routinely used in health care premises, is advocated.

  3. Antidepressant-Like Effects of Central BDNF Administration in Mice of Antidepressant Sensitive Catalepsy (ASC) Strain.

    PubMed

    Tikhonova, Maria; Kulikov, Alexander V

    2012-08-31

    Although numerous data evidence the implication of brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression, the potential for BDNF to correct genetically defined depressive-like states is poorly studied. This study was aimed to reveal antidepressant-like effects of BDNF (300 ng, 2×, i.c.v.) on behavior and mRNA expression of genes associated with depression-like state in the brain in mice of antidepressant sensitive catalepsy (ASC) strain characterized by high hereditary predisposition to catalepsy and depressive-like features. Behavioral tests were held on the 7th-16th days after the first (4th-13th after the second) BDNF injection. Results showed that BDNF normalized impaired sexual motivation in the ASC males, and this BDNF effect differed, with advantageous effects, from that of widely used antidepressants. The anticataleptic effect of two BDNF injections was enhanced compared with a single administration. A tendency to decrease the immobility duration in tail-suspension test was observed in BDNF-treated ASC mice. The effects on catalepsy and sexual motivation were specific since BDNF did not alter locomotor and exploratory activity or social interest in the ASC mice. Along with behavioral antidepressant-like effects on the ASC mice, BDNF increased hippocampal mRNA levels of Bdnf and Creb1 (cAMP response element-binding protein gene). BDNF also augmented mRNA levels of Arc gene encoding Arc (Activity-regulated cytoskeleton-associated) protein involved in BDNF-induced processes of neuronal and synaptic plasticity in hippocampus and prefrontal cortex. The data suggest that: [1] BDNF is effective in the treatment of some genetically defined behavioral disturbances; [2] BDNF influences sexually-motivated behavior; [3] Arc mRNA levels may serve as a molecular marker of BDNF physiological activity associated with its long-lasting behavioral effects; [4] ASC mouse strain can be used as a suitable model to study mechanisms of BDNF effects on

  4. Sedative effect of central administration of Coriandrum sativum essential oil and its major component linalool in neonatal chicks.

    PubMed

    Gastón, María Soledad; Cid, Mariana Paula; Vázquez, Ana María; Decarlini, María Florencia; Demmel, Gabriela I; Rossi, Laura I; Aimar, Mario Leandro; Salvatierra, Nancy Alicia

    2016-10-01

    Context Coriandrum sativum L. (Apiaceae) (coriander) is an herb grown throughout the world as a culinary, medicinal or essential crop. In traditional medicine, it is used for the relief of anxiety and insomnia. Systemic hydro-alcoholic and aqueous extract from aerial parts and seeds had anxiolytic and sedative action in rodents, but little is known about its central effect in chicks. Objective To study the effects of intracerebroventricular administration of essential oil from coriander seeds and its major component linalool on locomotor activity and emotionality of neonatal chicks. Materials and methods The chemical composition of coriander essential oil was determined by a gas-chromatographic analysis (> 80% linalool). Behavioural effects of central administration of coriander oil and linalool (both at doses of 0.86, 8.6 and 86 μg/chick) versus saline and a sedative diazepam dose (17.5 μg/chick, standard drug) in an open field test for 10 min were observed. Results Doses of 8.6 and 86 μg from coriander oil and linalool significantly decreased (p < 0.05) squares crossed number, attempted escapes, defecation number and distress calls, and significantly increased (p < 0.05) the sleeping posture on an open field compared with saline and were similar to the diazepam group. Discussion and conclusion The results indicate that intracerebroventricular injection of essential oil from Coriandrum sativum seeds induced a sedative effect at 8.6 and 86 μg doses. This effect may be due to monoterpene linalool, which also induced a similar sedative effect, and, therefore, could be considered as a potential therapeutic agent similar to diazepam.

  5. Evaluation and demonstration of decentralized space and water heating versus centralized services for new and rehabilitated multifamily buildings. Final report

    SciTech Connect

    Belkus, P.; Tuluca, A.

    1993-06-01

    The general objective of this research was aimed at developing sufficient technical and economic know-how to convince the building and design communities of the appropriateness and energy advantages of decentralized space and water heating for multifamily buildings. Two main goals were established to guide this research. First, the research sought to determine the cost-benefit advantages of decentralized space and water heating versus centralized systems for multifamily applications based on innovative gas piping and appliance technologies. The second goal was to ensure that this information is made available to the design community.

  6. NMDA receptors mediate heat shock protein induction in the mouse brain following administration of the ibotenic acid analogue AMAA.

    PubMed

    Planas, A M; Ferrer, I; Rodríguez-Farré, E

    1995-11-27

    Expression of inducible heat shock protein-70 (HSP-70) and hsp-70 mRNA were studied in the adult mouse brain following systemic administration of the ibotenic acid analogue (+/-)-2-amino-3-hydroxy-5-methyl-4-isoxazoleacetic acid (AMAA), which is a potent N-methyl-D-aspartate (NMDA) agonist. At the dose of 20 mg/kg, AMAA produced excitatory behaviours in adult mice but overt convulsions were not seen. This treatment did not result in any detectable morphological brain damage at 4 days following administration. At 2.5 h and 5 h following treatment induction of hsp-70 mRNA expression was found in the pyramidal cell layers of CA1 and, to a lesser extent, CA3 fields of hippocampal Ammon's horn, amygdala, olfactory lobes, tenia tecta, hypothalamic nuclei and a superficial layer of cingulate, frontal and retrosplenial cortices. The presence of HSP-70 was detected by immunochemistry at 24 h following drug administration in those regions previously showing hsp-70 mRNA induction. AMAA-induced hsp-70 mRNA expression was prevented by pre-treatment with the non-competitive NMDA antagonist MK-801. These results suggest that NMDA receptors are involved in the stress response induced by AMAA.

  7. Ozone pollution during heat wave periods over last 15 years in Central Europe

    NASA Astrophysics Data System (ADS)

    Struzewska, J.; Kaminski, J. W.; Jefimow, M.

    2012-04-01

    Periods characterized with the high ozone concentrations are usually associated with very high air temperature and antycyclonic conditions or meridional circulation. A 15-year (1997 - 2011) maximum daily temperature records from GSOD NOAA archive was analyzed for 20 stations in Central Europe. For each year the number of days with the maximum temperature exceeding 25oC and 30oC was calculated. For years with a positive anomaly of the number of the hot days the data were analyzed to identify exact dates and the duration of such events. This allows classification of the high temperature period as "heat waves" (periods with maximum temperature exceeding 30oC lasting at least 3 consecutive days) and hot weather periods (periods with maximum temperature exceeding 25oC and high daily average temperature). These two types of high temperature are usually associated with different air masses inflow - subtropical from the south or transformed polar from westerly directions. This indicates also the differences in contribution of transboundary transport of ozone and its precursors. For selected high temperature episodes the ozone pollution was assessed based on AirBase (1997-2009) and national database (2010-2011). The analysis covered the 8-hour running average and daily maximum concentration of ozone near the surface. Also, the contribution to the SOMO35 index during selected episodes will be calculated as a diagnostic for adverse health effects. Since the two analyzed types of hot weather periods have different origin in terms of synoptic scale situation, an attempt will be made to answer whether there are differences in the intensity of ozone episodes during selected hot weather periods. The outcome from the study will be useful for the interpretation of modelling results for air quality in future climate.

  8. Analysis of temperature trends, heat and cold waves in Central Italy (1952-2008)

    NASA Astrophysics Data System (ADS)

    Romano, E.; Volpi, E.; Stefanucci, F.

    2012-04-01

    Most of the recent studies on climate change agree in assessing a positive global trend of the mean temperature. However, analysis of temperature data at basin scale appears to be quite complicated because of several factors affecting measures: location, slope exposition, distance from the sea, etc., resulting in a high meteorological variability also at short distances. In this study we present an analysis of minimum and maximum daily temperature data registered in Umbria Region (Tiber Basin, Central Italy) for the period 1952-2008 in order to estimate mean trends and possible increases in the "extreme events" such us "heat waves" and "cold waves". Among the about 80 stations available for the study period, only those ones with at least 45 years of data, even not consecutive, have been retained, resulting in a data set of only 5 stations. Data have been analyzed at annual and seasonal time scale, taking into account the spatial trend due to the elevation. The spatial correlation among stations appear to be quite high, but not related to the reciprocal distances. The time trend of each temperature time series has been studied by means of classical trend tests (Mann-Kendall and t-Student test). Results are comparable for the two tests but not unique for minimum and maximum temperature. Concerning Tmax, 3 out of 5 stations present a positive trend in the last 30 years, ranging from 0.02 to 0.09 °C/y, while the remaining two stations do not present any significant trend; however, the same stations show a negative trend over the period 1960-1990. This results in a positive trend over the whole period 1952-2008 ranging from 0.02 to 0.03 °C/y. Concerning Tmin, 3 out of 5 of the study stations do not present any statistically significant trend over the last 30 years, while one station shows a negative trend (- 0.05 °C/y) and one a positive trend (+ 0.07 °C/y); moreover, 3 out of 5 stations have a significant positive trend in the period 1952-2008 (the annual

  9. Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1beta administration.

    PubMed

    Whitaker, Keith W; Reyes, Teresa M

    2008-03-01

    Loss of appetite and cachexia is an obstacle in the treatment of chronic infection and cancer. Proinflammatory cytokines released from activated immune cells and acting in the central nervous system (CNS) are prime candidates for mediating these metabolic changes, potentially affecting both energy intake as well as energy expenditure. The effect of intravenous administration of two proinflammatory cytokines, interleukin (IL)-1beta (15 microg/kg) and tumor necrosis factor (TNF)-alpha (10 microg/kg), on food and water intake, locomotor activity, oxygen consumption (VO2), and respiratory exchange ratio (RER) was evaluated. The two cytokines elicited a comparable decrease in food intake and activated similar numbers of cells in the paraventricular nucleus of the hypothalamus (PVH), a region that plays a critical role in the regulation of appetite and metabolism (determined via expression of the immediate early gene, c-fos). However, only IL-1beta reduced locomotion and RER, and increased VO2, while TNF-alpha was without effect. To examine the role of the melanocortins in mediating IL-1beta- induced metabolic changes, animals were pretreated centrally with a melanocortin receptor antagonist, HS014. Pretreatment with HS014 blocked the effect of IL-1beta on food intake and RER at later time points (beyond 8 h post injection), as well as the hypoactivity and increased metabolic rate. Further, HS014 blocked the induction of Fos-ir in the PVH. These data highlight the importance of the melanocortin system, particularly within the PVH, in mediating a broad range of metabolic responses to IL-1beta.

  10. Attenuation of systemic morphine-induced analgesia by central administration of ghrelin and related peptides in mice.

    PubMed

    Zeng, Ping; Chen, Jia-Xiang; Yang, Bei; Zhi, Xing; Guo, Fa-Xian; Sun, Meng-Li; Wang, Jing-Lei; Wei, Jie

    2013-12-01

    Ghrelin, an acylated 28-amino peptide secreted in the gastric endocrine cells, has been demonstrated to stimulate the release of growth hormone, increase food intake, and inhibit pro-inflammatory cascade, etc. Ghrelin mainly combines with its receptor (GHS-R1α) to play the role in physiological and pathological functions. It has been reported that ghrelin plays important roles in the control of pain through interaction with the opioid system in inflammatory pain and acute pain. However, very few studies show the effect of supraspinal ghrelin system on antinociception induced by intraperitoneal (i.p.) administration of morphine. In the present study, intracerebroventricular (i.c.v.) injection of ghrelin (0.1, 1, 10 and 100 nmol/L) produced inhibition of systemic morphine (6 mg/kg, i.p.) analgesia in the tail withdrawal test. Similarly, i.c.v. injection GHRP-6 and GHRP-2 which are the agonists of GHS-R1α, also decreased analgesia effect induced by morphine injected intraperitoneally in mice. Furthermore, these anti-opioid activities of ghrelin and related peptides were not blocked by pretreatment with the GHS-R1α selective antagonist [d-Lys(3)]-GHRP-6 (100 nmol/L, i.c.v.). These results demonstrated that central ghrelin and related peptides could inhibit the analgesia effect induced by intraperitoneal (i.p.) administration of morphine. The anti-opioid effects of ghrelin and related peptides do not interact with GHS-R1a. These findings may pave the way for a new strategy on investigating the interaction between ghrelin system and opioids on pain modulation.

  11. Heat flow in Railroad Valley, Nevada and implications for geothermal resources in the south-central Great Basin

    USGS Publications Warehouse

    Williams, C.F.; Sass, J.H.

    2006-01-01

    The Great Basin is a province of high average heat flow (approximately 90 mW m-2), with higher values characteristic of some areas and relatively low heat flow (<60 mW m-2) characteristic of an area in south-central Nevada known as the Eureka Low. There is hydrologie and thermal evidence that the Eureka Low results from a relatively shallow, hydrologically controlled heat sink associated with interbasin water flow in the Paleozoic carbonate aquifers. Evaluating this hypothesis and investigating the thermal state of the Eureka Low at depth is a high priority for the US Geological Survey as it prepares a new national geothermal resource assessment. Part of this investigation is focused on Railroad Valley, the site of the largest petroleum reservoirs in Nevada and one of the few locations within the Eureka Low with a known geothermal system. Temperature and thermal conductivity data have been acquired from wells in Railroad Valley in order to determine heat flow in the basin. The results reveal a complex interaction of cooling due to shallow ground-water flow, relatively low (49 to 76 mW m-2) conductive heat flow at depth in most of the basin, and high (up to 234 mW m-2) heat flow associated with the 125??C geothermal system that encompasses the Bacon Flat and Grant Canyon oil fields. The presence of the Railroad Valley geothermal resource within the Eureka Low may be reflect the absence of deep ground-water flow sweeping heat out of the basin. If true, this suggests that other areas in the carbonate aquifer province may contain deep geothermal resources that are masked by ground-water flow.

  12. Examining Perceptions of Administrators, Teachers, Parents, and Community Residents about Advantages and Disadvantages of Consolidating Two High Schools in a School District in Central Pennsylvania

    ERIC Educational Resources Information Center

    Ackell, Robert J.

    2013-01-01

    This mixed methods triangulation approach examined the perceptions of administrators, teachers, parents, and community residents about a consideration of a secondary school consolidation in a school district in central Pennsylvania. These groups are referred to as "stakeholders" in this study. The purpose of this research was to develop…

  13. Contracting Out. National Oceanic and Atmospheric Administration's Central Library. Report to the Chairman, Subcommittee on Commerce, Justice, State, and the Judiciary, Committee on Appropriations, U.S. Senate.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    In response to a request by the Senate Committee on Appropriations for an examination of the A-76 program of the Department of Commerce's National Oceanic and Atmospheric Administration (NOAA), in particular NOAA's decision to contract for the operation of its Central Library, this report describes a General Accounting Office (GAO) review which:…

  14. Solar space and water heating system at Stanford University Central Food Services Building. Final report

    SciTech Connect

    Not Available

    1980-05-01

    This active hydronic domestic hot water and space heating system was 840 ft/sup 2/ of single-glazed, liquid, flat plate collectors and 1550 gal heat storage tanks. The following are discussed: energy conservation, design philosophy, operation, acceptance testing, performance data, collector selection, bidding, costs, economics, problems, and recommendations. An operation and maintenance manual and as-built drawings are included in appendices. (MHR)

  15. Wastewater recycling and heat reclamation at the Red Lion Central Laundry, Portland, Oregon

    SciTech Connect

    Garlick, T.F.; Halverson, M.A.; Ledbetter, M.R.

    1996-09-01

    This report discusses water, energy, and cost savings that can be achieved in a commercial laundry through the use of a wastewater recycling and heat recovery system. Cost savings are achieved through reductions in water use, reduction in sewage charges, reductions in water heating energy, and potential reductions in water treatment chemicals. This report provides an economic analysis of the impact of capital investment, daily consumption, and local utility rates on the payback period.

  16. Inactivation of the central nucleus of the amygdala reduces the effect of punishment on cocaine self-administration in rats.

    PubMed

    Xue, YueQiang; Steketee, Jeffery D; Sun, WenLin

    2012-03-01

    Continued cocaine use despite the negative consequences is a hallmark of cocaine addiction. One such consequence is punishment, which is often used by society to curb cocaine use. Unfortunately, we know little about the mechanism involved in regulation by punishment of cocaine use. The fact that cocaine addicts continue to use cocaine despite potentially severe punishment suggests that the mechanism may be impaired. Such impairment is expected to critically contribute to compulsive cocaine use. This study was aimed at testing the hypothesis that the central nucleus of the amygdala (CeN) plays a critical role in such regulation. To this end, rats were trained to press a lever to self-administer cocaine under a chained schedule: a response on one lever (cocaine-seeking lever) led to access to the other lever (cocaine-taking lever), on which a response was reinforced by cocaine and cues. Thereafter, responses on the seeking lever were punished by footshock with a probability of 0.5. Cocaine self-administration (SA) was significantly suppressed by punishment in an intensity-dependent manner. Interestingly, rats trained with daily 6-h (extended access) but not 2-h (limited access) sessions showed resistance to the lower intensity of punishment. Inactivation of the CeN induced a robust anti-punishment effect in both groups. These data provided evidence that the CeN is a critical neural substrate involved in regulation by punishment of cocaine SA. Rats with a history of extended cocaine SA appeared to be less sensitive to punishment. The decreased sensitivity could result from the neuroplastic changes induced by extended cocaine SA in the CeN.

  17. Influence of Route of Administration on Immediate and Extended Protection in Rats Immunized with Escherichia coli Heat-Labile Enterotoxin

    PubMed Central

    Klipstein, Frederick A.; Engert, Richard F.

    1980-01-01

    The effect of route of administration, dosage, and number of boosts employed during immunization with the polymyxin-release form of Escherichia coli heat-labile (LT) enterotoxin on the degree and duration of protection afforded was evaluated in rats which were challenged by the ligated loop technique. Increasing the boosting dosage by fivefold from 50 to 250 μg resulted in a marked increase in protection against challenge with toxin in rats immunized either just by the parenteral route (i.p./i.p.) or by a parenteral prime, followed by peroral boosts (i.p./p.o.) in rats pretreated with cimetidine to ablate gastric secretions; such was not the case, however, even with a 50-fold increase in dosage in rats immunized just by the peroral route (p.o./p.o.). Four weekly peroral boosts were required to achieve the strongest degree of protection. Increasing the boosting dosage also increased the degree of protection against challenge with viable LT+/ST− and LT+/ST+ strains (ST indicates heat-stable enterotoxin) in rats immunized by the i.p./p.o., but not by the i.p./i.p., route; no protection was evident against an LT−/ST+ strain. Protection was lost within 3 weeks after immunization in rats immunized by the i.p./i.p. route. In contrast, protection was extended over the 3-month observation period in those immunized by the i.p./p.o. route; the degree of protection was enhanced in rats which received an additional boost at 2 months. These observations establish the fact that immunization with LT is similar to that with cholera toxin in that arousal of the local immune intestinal response by means of peroral immunization provides maximal extended protection. PMID:6987180

  18. Cytoskeletal stability and heat shock-mediated thermoprotection of central pattern generation in Locusta migratoria.

    PubMed

    Garlick, Kristopher M; Robertson, R Meldrum

    2007-06-01

    Prior exposure to extreme temperatures can induce thermoprotection in migratory locusts, which is important for survival in their natural environment. An important motor activity that needs to be protected is ventilation. The mechanism underlying heat shock is not fully understood, and our goal was to test the idea that cytoskeletal stability is critical for such thermoprotection. Cytoskeletal stabilizers (concanavalin A) and destabilizers (colchicine) were bath-applied in semi-intact locust preparations in both control (C) and pre-treated heat-shocked (3 h, 45 degrees C) animals. We measured parameters of the ventilatory motor pattern during maintained high temperature (43 degrees C) and recorded the times taken for motor pattern generation to fail and then recover on returning to room temperature. We found that concanavalin A mimicked the effects of a prior heat stress in control animals by increasing time to failure and decreasing time to recovery of motor pattern generation. However, colchicine destroyed protection in heat-shocked animals by decreasing time to failure and increasing time to recovery. Our findings confirm that the cytoskeleton has a mechanistic role in preserving neural function at high temperatures, possibly through stabilizing ion channels and other integral membrane proteins (e.g. Na(+)/K(+) ATPase) and their interactions with heat shock proteins.

  19. Regional expression of inducible heat shock protein-70 mRNA in the rat brain following administration of convulsant drugs.

    PubMed

    Planas, A M; Soriano, M A; Ferrer, I; Rodríguez Farré, E

    1994-11-01

    Expression of inducible heat shock protein-70 mRNA (hsp-70 mRNA) was studied in the rat brain following systemic administration of different convulsant agents: an L-type voltage-dependent calcium channel agonist, (+/-)-BAY K 8644 (BAY-K); the excitotoxic glutamate agonists kainic acid and N-methyl-D-aspartic acid (NMDA); and the GABAA receptor complex antagonists pentylenetetrazole (PTZ) and lindane (gamma-hexaclorocyclohexane). BAY-K induced minimal hsp-70 mRNA expression in the hippocampus of convulsant rats, localized in the dentate gyrus and the pyramidal cell layer of Ammon's horn. Kainic acid treatment in rats, showing severe limbic convulsions, caused intense expression of hsp-70 mRNA and protein (HSP-70). Expression was localized in select cerebral regions, notably the pyramidal cell layer of the hippocampal CA3 field of Ammon's horn and the piriform cortex, and also the subicular complex and the amygdala, and, to a lesser extent, the entorhinal cortex, the pyramidal cell layer of CA1, several thalamic nuclei, and the parietal cortex. In contrast, systemic administration of NMDA, PTZ or lindane led to no detectable induction of hsp-70 mRNA in the rat brain, despite producing convulsions. Histological examination revealed cell injury only following kainic acid treatment. Damage was most apparent in the piriform and entorhinal cortices, pyramidal cell layer of the CA1 field, and cortical amygdaloid nuclei. BAY-K, NMDA, PTZ and lindane did not lead to any observable histopathological changes. These results show that convulsions of different aetiology do not inevitably induce hsp-70 mRNA expression or cell damage. Intense expression of hsp-70 mRNA was generally associated with regions that later showed variable degrees of nerve cell damage, although hsp-70 mRNA expression was not always predictive of subsequent cell death or survival.

  20. Intranasal administration of milnacipran in rats: evaluation of the transport of drugs to the systemic circulation and central nervous system and the pharmacological effect.

    PubMed

    Uchida, Masaki; Katoh, Takuya; Mori, Mutsuhiro; Maeno, Takuya; Ohtake, Kazuo; Kobayashi, Jun; Morimoto, Yasunori; Natsume, Hideshi

    2011-01-01

    Recently, transnasal drug delivery has attracted a great deal of attention as an administration route to deliver drugs directly to the central nervous systems (CNS) and drug targeting of the CNS is expected to increase. In the present study, we investigated the possibility of using a transnasal delivery system for milnacipran, a serotonin-noradrenaline reuptake inhibitor (SNRI), by evaluating the transport to the systemic circulation and cerebrospinal fluid (CSF) and the pharmacological effect after intranasal (i.n.) administration. Moreover, the effect of chitosan as a bioadhesive material on the transport to the systemic circulation and CSF and the pharmacological effect after i.n. administration were evaluated. As a result, i.n. administration of milnacipran was found to produce a higher direct delivery to the CNS as well as to the systemic circulation, suggesting that this is a promising route of administration and an alternative to peroral (p.o.) administration. Furthermore, the i.n. co-administration with chitosan led to increased plasma and CSF concentrations and an enhanced pharmacological effect, evaluated by means of the forced swimming test. The results suggested that chitosan produced a long residence time of milnacipran in the nasal cavity due to its bioadhesive effect, leading to the enhanced transport of milnacipran from the systemic circulation to the CNS via the blood-brain barrier by an increase in systemic absorption as well as direct transport to the CNS, resulting in a higher antidepressant effect compared to that with p.o. administration.

  1. Heat flow and thermotectonic problems of the central Ventura Basin, southern California

    USGS Publications Warehouse

    De Rito, R. F.; Lachenbruch, A.H.; Moses, T.H.; Munroe, R.J.

    1989-01-01

    The Ventura Basin, southern California, is located near the Big Bend area of the San Andreas fault system, within the Transverse Ranges physiographic province. Negative curvature of the Ventura Avenue temperature profiles may be explained by an increase in thermal conductivity associated with tectonic compaction of the underlying Pliocene clastic sequence. Basinwide, heat flow averages about 48 mW/m2, a value which is low relative to most of southern California. As heat flow does not vary systematically to the maximum measured depth of about 4 km, this anomly is not easily explained in terms of hydrologic effects or recent uplift and erosion. However, a diminution of heat flow is an expectable consequence of the accumulation of cold sediments (up to 12 km) since Eocene time. -from Authors

  2. Heat Flow and Geothermal Potential in the South-Central United States

    SciTech Connect

    Negraru, Petru T. Blackwell, David D.; Erkan, Kamil

    2008-12-15

    Geothermal exploration is typically limited to high-grade hydrothermal reservoirs that are usually found in the western United States, yet large areas with subsurface temperatures above 150 deg. C at economic drilling depths can be found east of the Rocky Mountains. The object of this paper is to present new heat flow data and to evaluate the geothermal potential of Texas and adjacent areas. The new data show that, west of the Ouachita Thrust Belt, the heat flow values are lower than east of the fault zone. Basement heat flow values for the Palo Duro and Fort Worth Basins are below 50 mW/m{sup 2} while, in the frontal zone of the belt, they can exceed 60 mW/m{sup 2}. Further east, along the Balcones fault system the heat flow is in general higher than 55 mW/m{sup 2}. The eastern most heat flow sites are in Louisiana and they show very high heat flow (over 80 mW/m{sup 2}), which is associated with the apparently highly radioactive basement of the Sabine uplift. The geothermal resource in this area is large and diverse, and can be divided in high grade (temperature above 150 deg. C) convective systems, conductive based enhanced geothermal systems and geothermal/geopressured systems. One of the most attractive areas east of the cordillera extends from eastern Texas across Louisiana and Arkansas to western Mississippi. Here temperatures reach exploitation range at depths below 4 km, and tapping such a resource from shut in hydrocarbon fields is relatively easy. The initial costs of the development can be greatly reduced if existing hydrocarbon infrastructure is used, and therefore using shut-in hydrocarbon fields for geothermal purposes should not be neglected.

  3. Central unresolved issues in thermal energy storage for building heating and cooling

    SciTech Connect

    Swet, C.J.; Baylin, F.

    1980-07-01

    This document explores the frontier of the rapidly expanding field of thermal energy storage, investigates unresolved issues, outlines research aimed at finding solutions, and suggests avenues meriting future research. Issues related to applications include value-based ranking of storage concepts, temperature constraints, consistency of assumptions, nomenclature and taxonomy, and screening criteria for materials. Issues related to technologies include assessing seasonal storage concepts, diurnal coolness storage, selection of hot-side storage concepts for cooling-only systems, phase-change storage in building materials, freeze protection for solar water heating systems, and justification of phase-change storage for active solar space heating.

  4. Acute central administration of immepip, a histamine H3 receptor agonist, suppresses hypothalamic histamine release and elicits feeding behavior in rats.

    PubMed

    Chiba, Seiichi; Itateyama, Emi; Sakata, Toshiie; Yoshimatsu, Hironobu

    2009-04-06

    Histamine suppresses feeding behavior via histamine H1 receptors in the hypothalamus. This study was performed to examine whether the acute reduction of histamine release in the hypothalamus caused by immepip, a histamine H3 agonist, modulates the feeding behavior of rats. Rats had a catheter implanted in the third cerebral ventricle (i3v) and were given central injections of phosphate-buffered-saline or immepip (100-300 pmol/rat). Following the i3v administration of immepip, the rats developed dose-dependent hypokinesia within 10 min of administration. Next to hypokinesia, the rats showed significant dose-dependent feeding behavior. High-performance liquid chromatography (HPLC) confirmed the reduction in histamine release in the hypothalamus of rats following i3v administration of immepip. These results suggest that i3v administration of immepip, an H3 receptor agonist, suppresses hypothalamic histamine release and elicits feeding behavior in rats.

  5. Central limit theorem for the solution to the heat equation with moving time

    NASA Astrophysics Data System (ADS)

    Liu, Junfeng; Tudor, Ciprian A.

    2016-03-01

    We consider the solution to the stochastic heat equation driven by the time-space white noise and study the asymptotic behavior of its spatial quadratic variations with “moving time”, meaning that the time variable is not fixed and its values are allowed to be very big or very small. We investigate the limit distribution of these variations via Malliavin calculus.

  6. Safety review package for University of Central Florida flat-plate heat pipe experiment

    NASA Technical Reports Server (NTRS)

    Chow, Louis C.

    1998-01-01

    A flat-plate heat pipe (FPHP) experiment has been set up for micro-gravity tests on a NASA supplied aircraft. This report presents an analysis on various components of the experimental setup to certify that it will satisfy the flight safety and operation requirements.

  7. Case Study: Fuel Cells Provide Combined Heat and Power at Verizon's Garden City Central Office

    SciTech Connect

    2010-12-01

    This case study describes how Verizon's Central Office in Garden City, NY, installed a 1.4-MW phosphoric acid fuel cell system as an alternative solution to bolster electric reliability, optimize the company's energy use, and reduce costs in an environmentally responsible manner.

  8. Report of results of benchmarking survey of central heating operations at NASA centers and various corporations

    NASA Technical Reports Server (NTRS)

    Hoffman, Thomas R.

    1995-01-01

    In recent years, Total Quality Management has swept across the country. Many companies and the Government have started looking at every aspect on how business is done and how money is spent. The idea or goal is to provide a service that is better, faster and cheaper. The first step in this process is to document or measure the process or operation as it stands now. For Lewis Research Center, this report is the first step in the analysis of heating plant operations. This report establishes the original benchmark that can be referred to in the future. The report also provides a comparison to other organization's heating plants to help in the brainstorming of new ideas. The next step is to propose and implement changes that would meet the goals as mentioned above. After the changes have been implemented the measuring process starts over again. This provides for a continuous improvement process.

  9. Wastewater recycling and heat reclamation project: Red Lion Central Laundry, Portland, Oregon

    SciTech Connect

    Garlick, T.F.; Halverson, M.A.; Ledbetter, M.R.

    1997-06-01

    This report discusses water, energy, and cost savings that can be achieved in a commercial laundry through the use of a wastewater recycling and heat recovery system. Cost savings are achieved through reductions in water use, reduction in sewage charges (typically based on water use), reductions in water heating energy, and potential reductions in water treatment chemicals because the recycled water has already been treated with soaps and conditioners. A recovery system saves water by recycling wash water that would normally be dumped into the city sewage system. Recycling the wash water produces considerable energy savings because the recycled water has a higher temperature than fresh water. As a result, a hot water heater consumes less energy to heat the recycled water. The demonstration project discussed in this report was based in a large commercial laundry in Portland, Oregon. The laundry serves a large hotel/motel chain and processes an average of 25,000 pounds of laundry per day. A wastewater recovery system using a membrane microfiltration unit (MFU) was installed in the laundry in September 1995. Time series data of the water and energy consumption of the laundry were taken before and after installation of the MFU. Energy savings were measured by performing a thermal energy balance around the washing machines. Water savings were calculated by metering volumetric flow rates. After a period of approximately five months, the MFU has achieved final results of 52 percent savings in water consumption and 44 percent savings in energy to heat water. This five-month period represents a learning curve during which several small technical improvements were made to the MFU and laundry staff adjusted laundry operations to maximize the benefits of the MFU. An economic analysis discusses the impact of capital investment, daily consumption, and local utility rates on the payback period.

  10. Fast ignition when heating the central part of an inertial confinement fusion target by an ion beam

    SciTech Connect

    Gus’kov, S. Yu.; Zmitrenko, N. V.; Il’in, D. V.; Sherman, V. E.

    2014-11-15

    We investigate the ignition and burning of a precompressed laser fusion target when it is rapidly heated by an ion beam with the formation of a temperature peak in the central part of the target. We present the results of our comprehensive numerical simulations of the problem that include the following components: (1) the target compression under the action of a profiled laser pulse, (2) the heating of the compressed target with spatially nonuniform density and temperature distributions by a beam of high-energy ions, and (3) the burning of the target with the initial spatial density distribution formed at the instant of maximum target compression and the initial spatial temperature distribution formed as a result of the compressed-target heating by an ion beam. The dependences of the threshold energies of the igniting ion beam and the thermonuclear gain on the width of the Gaussian beam ion energy spectrum have been established. The peculiarities of fast ignition by an ion beam related to the spatial distribution of parameters for the target precompressed by a laser pulse are discussed.

  11. Gallium-cladding compatibility testing plan: Phase 3 -- Test plan for centrally heated surrogate rodlet test. Revision 2

    SciTech Connect

    Morris, R.N.; Baldwin, C.A.; Wilson, D.F.

    1998-07-01

    The Fissile Materials Disposition Program (FMDP) is investigating the use of weapons grade plutonium in mixed oxide (MOX) fuel for light-water reactors (LWR). Commercial MOX fuel has been successfully used in overseas reactors for many years; however, weapons derived fuel may differ from the previous commercial fuels because of small amounts of gallium impurities. A concern presently exists that the gallium may migrate out of the fuel, react with and weaken the clad, and thereby promote loss of fuel pin integrity. Phases 1 and 2 of the gallium task are presently underway to investigate the types of reactions that occur between gallium and clad materials. This is a Level-2 document as defined in the Fissile Materials Disposition Program Light-Water Reactor Mixed-Oxide Fuel Irradiation Test Project Plan. This Plan summarizes the projected Phase 3 Gallium-Cladding compatibility heating test and the follow-on post test examination (PTE). This work will be performed using centrally-heated surrogate pellets, to avoid unnecessary complexities and costs associated with working with plutonium and an irradiation environment. Two sets of rodlets containing pellets prepared by two different methods will be heated. Both sets will have an initial bulk gallium content of approximately 10 ppm. The major emphasis of the PTE task will be to examine the material interactions, particularly indications of gallium transport from the pellets to the clad.

  12. Monitored performance of residential geothermal heat pumps in central Texas and Southern Michigan

    SciTech Connect

    Sullivan, W.N.

    1997-11-01

    This report summarizes measured performance of residential geothermal heat pumps (GHP`s) that were installed in family housing units at Ft. Hood, Texas and at Selfridge Air National Guard base in Michigan. These units were built as part of a joint Department of Defense/Department of Energy program to evaluate the energy savings potential of GHP`s installed at military facilities. At the Ft. Hood site, the GHP performance was compared to conventional forced air electric air conditioning and natural gas heating. At Selfridge, the homes under test were originally equipped with electric baseboard heat and no air conditioning. Installation of the GHP systems at both sites was straightforward but more problems and costs were incurred at Selfridge because of the need to install ductwork in the homes. The GHP`s at both sites produced impressive energy savings. These savings approached 40% for most of the homes tested. The low cost of energy on these bases relative to the incremental cost of the GHP conversions precludes rapid payback of the GHP`s from energy savings alone. Estimates based on simple payback (no inflation and no interest on capital) indicated payback times from 15 to 20 years at both sites. These payback times may be reduced by considering the additional savings possible due to reduced maintenance costs. Results are summarized in terms of 15 minute, hourly, monthly, and annual performance parameters. The results indicate that all the systems were working properly but several design shortcomings were identified. Recommendations are made for improvements in future installations at both sites.

  13. Effects of vertically ribbed surface roughness on the forced convective heat losses in central receiver systems

    NASA Astrophysics Data System (ADS)

    Uhlig, Ralf; Frantz, Cathy; Fritsch, Andreas

    2016-05-01

    External receiver configurations are directly exposed to ambient wind. Therefore, a precise determination of the convective losses is a key factor in the prediction and evaluation of the efficiency of the solar absorbers. Based on several studies, the forced convective losses of external receivers are modeled using correlations for a roughened cylinder in a cross-flow of air. However at high wind velocities, the thermal efficiency measured during the Solar Two experiment was considerably lower than the efficiency predicted by these correlations. A detailed review of the available literature on the convective losses of external receivers has been made. Three CFD models of different level of detail have been developed to analyze the influence of the actual shape of the receiver and tower configuration, of the receiver shape and of the absorber panels on the forced convective heat transfer coefficients. The heat transfer coefficients deduced from the correlations have been compared to the results of the CFD simulations. In a final step the influence of both modeling approaches on the thermal efficiency of an external tubular receiver has been studied in a thermal FE model of the Solar Two receiver.

  14. Electron cyclotron heating and current drive for maintaining minimum q in negative central shear discharges

    NASA Astrophysics Data System (ADS)

    Casper, T. A.; Kaiser, T. B.; Jong, R. A.; Destro, L. L. Lo; Moller, J.; Pearlstein, L. D.; Dodge, T.

    2003-07-01

    Toroidal plasmas created with negative magnetic shear in the core region offer advantages in terms of MHD stability properties. These plasmas, transiently created in several tokamaks, have exhibited high-performance as measured by normalized stored energy and neutron production rates. A critical issue with extending the duration of these plasmas is the need to maintain the off-axis-peaked current distribution required to support the minimum in the safety factor q at large radii. We present equilibrium and transport simulations that explore the use of electron cyclotron heating and current drive to maintain this negative shear configuration. Using parameters consistent with DIII-D tokamak operation (Strait E et al 1995 Phys. Rev. Lett. 75 4421, Rice B W et al 1996 Nucl. Fusion 36 1271), we find that with sufficiently high injected power, it is possible to achieve steady-state conditions employing well aligned electron cyclotron and bootstrap current drive in fully non-inductively current-driven configurations.

  15. Ground-water temperature of the Wyoming quadrangle in central Delaware : with application to ground-water-source heat pumps

    USGS Publications Warehouse

    Hodges, Arthur L.

    1982-01-01

    Ground-water temperature was measured during a one-year period (1980-81) in 20 wells in the Wyoming Quadrangle in central Delaware. Data from thermistors set at fixed depths in two wells were collected twice each week, and vertical temperature profiles of the remaining 18 wells were made monthly. Ground-water temperature at 8 feet below land surface in well Jc55-1 ranged from 45.0 degrees F in February to 70.1 degrees F in September. Temperature at 35 feet below land surface in the same well reached a minimum of 56.0 degrees F in August, and a maximum of 57.8 degrees F in February. Average annual temperature of ground water at 25 feet below land surface in all wells ranged from 54.6 degrees F to 57.8 degrees F. Variations of average temperature probably reflect the presence or absence of forestation in the recharge areas of the wells. Ground-water-source heat pumps supplied with water from wells 30 or more feet below land surface will operate more efficiently in both heating and cooling modes than those supplied with water from shallower depths. (USGS)

  16. Surface heating and patchiness in the coastal ocean off central California during a wind relaxation event

    NASA Technical Reports Server (NTRS)

    Ramp, Steven R.; Garwood, Roland W.; Snow, Richard L.; Davis, Curtiss O.

    1991-01-01

    The difference between the temperature of the ocean at 4-cm and 2-m depth was continuously monitored during a cruise to the coastal transition zone off Point Arena, California, during June 1987. The two temperatures were coincident most of the time but diverged during one nearshore leg of the cruise where large temperature differences of up to 4.7 C were observed between the 4-cm and 2-m sensors, in areas which were separated by regions where the two temperatures were coincident as usual. The spatial scale of this 'patchy' thermal structure was about 5-10 km. A mixed layer model (Garwood, 1977) was used to simulate the near surface stratification when forced by the observed wind stress, surface heating, and optical clarity of the water. The model produced a thin strongly stratified surface layer at stations where exceptionally high turbidity was observed but did not produce such features otherwise. This simple model could not explain the horizontal patchiness in the thermal structure, which was likely due to patchiness in the near-surface chlorophyll distributions or to submesoscale variability of the surface wind stress.

  17. In search of a heating source for the generation of an anatectic complex: Peña Negra, Central Spain

    NASA Astrophysics Data System (ADS)

    Pereira, D.

    2003-04-01

    The Peña Negra complex in the north-central part of the Sierra de Gredos, Avila batholith, central Spain, provides a superb opportunity for the study of Variscan partial melting processes. The erosional level displayed may be considered to be that at which the Hercynian granites were produced. The protolith for the anatectic melts appears to have been the Schistogreywacke complex, together with the gneisses that were the main source for the Iberian granites (Pereira and Rodríguez-Alonso, 2000). However, the heat source for the anatexis remains controversial. The presence of basic rocks in the vicinity has given rise to the suggestion that mafic magmas of mantle origin may have been involved in the generation of the anatectic granites. Whilst data from experimental petrology may be used to support this concept, the volumes of mafic magma necessary for the anatexis appear improbably large. Geophysical models for Central Iberia do not support the presence of the requisite large basic complexes at depth. Furthermore radiometric dating of the scarce basic outcrops indicates that they are too old to have been involved in the granitic magma genesis. The alternative interpretation put forward here is that melting of the protolith was promoted by the radioactive decay of K, U and Th, elements that are present in relatively high concentrations in the supposed protolith rocks. Anatexis was enhanced by the presence of shear structures that permitted the concentration of volatiles as well as by existence of a fertile protolith. The situation is believed to have been analogous to that in other European Variscan terrains.

  18. The Development of a Series of Recommendations and Procedures Required in Administration of a Centralized Program of Occupational Competency Assessment.

    ERIC Educational Resources Information Center

    Hoyman, Ronald D.

    A study was conducted to provide information and representative examples necessary for the establishment of administrative procedures required in conducting a statewide program to assess the occupational competency of vocational-technical instructors. The data used in the study was obtained from a review of the current literature, samples of forms…

  19. Anxiolytic-like effect of central administration of NOP receptor antagonist UFP-101 in rats submitted to the elevated T-maze.

    PubMed

    Duzzioni, Marcelo; Duarte, Filipe S; Leme, Leandro R; Gavioli, Elaine C; De Lima, Thereza C M

    2011-09-12

    Depression and anxiety disorders present several genetic and neurobiological similarities. Drugs with antidepressant activity are effective in the treatment of a wide spectrum of anxiety disorders. Preclinical results showed that acute and chronic treatment with the NOP antagonist [Nphe(1),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-101) produced antidepressant-like effects in rodents. Thus, the present study aimed to investigate the effect of central administration of UFP-101 on the anxiety-related behavior in rats as evaluated in the elevated T-maze (ETM) test. Our results showed that UFP-101 reduced the latency of inhibitory avoidance in the ETM, indicating an anxiolytic-like effect. The endogenous peptide N/OFQ prevented this anxiolytic-like action of UFP-101, demonstrating its modulation via central NOP receptors. However, UFP-101 failed to interfere with the latency to escape. No change was observed in locomotor activity after UFP-101 treatment, ruling out any nonspecific motor effect. In conclusion, our results showed that the central administration of UFP-101 presents an anxiolytic-like effect in rats evaluated in the ETM test, providing new insights for drug development to treat anxiety disorders targeting the N/OFQ-NOP receptor system.

  20. Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism.

    PubMed

    Burgos-Ramos, Emma; Canelles, Sandra; Rodríguez, Amaia; Gómez-Ambrosi, Javier; Frago, Laura M; Chowen, Julie A; Frühbeck, Gema; Argente, Jesús; Barrios, Vicente

    2015-11-05

    Leptin and insulin use overlapping signaling mechanisms to modify hepatic glucose metabolism, which is critical in maintaining normal glycemia. We examined the effect of an increase in central leptin and insulin on hepatic glucose metabolism and its influence on serum glucose levels. Chronic leptin infusion increased serum leptin and reduced hepatic SH-phosphotyrosine phosphatase 1, the association of suppressor of cytokine signaling 3 to the insulin receptor in liver and the rise in glycemia induced by central insulin. Leptin also decreased hepatic phosphoenolpyruvate carboxykinase levels and increased insulin's ability to phosphorylate insulin receptor substrate-1, Akt and glycogen synthase kinase on Ser9 and to stimulate glucose transporter 2 and glycogen levels. Peripheral leptin treatment reproduced some of these changes, but to a lesser extent. Our data indicate that leptin increases the hepatic response to a rise in insulin, suggesting that pharmacological manipulation of leptin targets may be of interest for controlling glycemia.

  1. Comparing Administrative and Clinical Data for Central Line Associated Blood Stream Infections in Pediatric Intensive Care Unit and Pediatric Cardiothoracic Intensive Care Unit

    PubMed Central

    Bond, Jory; Issa, Mohamed; Nasrallah, Ali; Bahroloomi, Sheena; Blackwood, Roland A.

    2016-01-01

    Central line associated bloodstream infections (CLABSIs) are a frequent source of health complication for patients of all ages, including for patients in the pediatric intensive care unit (PICU) and Pediatric Cardiothoracic Intensive Care Unit (PCTU). Many hospitals, including the University of Michigan Health System, currently use the International Classification of Disease (ICD) coding system when coding for CLABSI. The purpose of this study was to determine the accuracy of coding for CLABSI infections with ICD-9CM codes in PICU and PCTU patients. A retrospective chart review was conducted for 75 PICU and PCTU patients with 90 events of hospital acquired central line infections at the University of Michigan Health System (from 2007-2011). The different variables examined in the chart review included the type of central line the patient had, the duration of the stay of the line, the type of organism infecting the patient, and the treatment the patient received. A review was conducted to assess if patients had received the proper ICD-9CM code for their hospital acquired infection. In addition, each patient chart was searched using Electronic Medical Record Search Engine to determine if any phrases that commonly referred to hospital acquired CLABSIs were present in their charts. Our review found that in most CLABSI cases the hospital’s administrative data diagnosis using ICD-9CM coding systems did not code for the CLABSI. Our results indicate a low sensitivity of 32% in the PICU and an even lower sensitivity of 12% in the PCTU. Using these results, we can conclude that the ICD-9CM coding system cannot be used for accurately defining hospital acquired CLABSIs in administrative data. With the new use of the ICD-10CM coding system, further research is needed to assess the effects of the ICD-10CM coding system on the accuracy of administrative data.

  2. Central Administration of Insulin and Leptin Together Enhance Renal Sympathetic Nerve Activity and Fos Production in the Arcuate Nucleus

    PubMed Central

    Habeeballah, Hamza; Alsuhaymi, Naif; Stebbing, Martin J.; Jenkins, Trisha A.; Badoer, Emilio

    2017-01-01

    There is considerable interest in the central actions of insulin and leptin. Both induce sympatho-excitation. This study (i) investigated whether centrally administered leptin and insulin together elicits greater increases in renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) than when given alone, and (ii) quantified the number of activated neurons in brain regions influencing SNA, to identify potential central sites of interaction. In anesthetised (urethane 1.4–1.6 g/kg iv) male Sprague-Dawley rats, RSNA, MAP, and HR were recorded following intracerebroventricular (ICV) saline (control; n = 5), leptin (7 μg; n = 5), insulin (500 mU; n = 4) and the combination of leptin and insulin; (n = 4). Following leptin or insulin alone, RSNA was significantly increased (74 and 62% respectively). MAP responses were not significantly different between the groups. Insulin alone significantly increased HR. Leptin alone also increased HR but it was significantly less than following insulin alone (P < 0.005). When leptin and insulin were combined, the RSNA increase (124%) was significantly greater than the response to either alone. There were no differences between the groups in MAP responses, however, the increase in HR induced by insulin was attenuated by leptin. Of the brain regions examined, only in the arcuate nucleus did leptin and insulin together increase the number of Fos-positive cell nuclei significantly more than leptin or insulin alone. In the lamina terminalis and rostroventrolateral medulla, leptin and insulin together increased Fos, but the effect was not greater than leptin alone. The results suggest that when central leptin and insulin levels are elevated, the sympatho-excitatory response in RSNA will be greater. The arcuate nucleus may be a common site of cardiovascular integration. PMID:28119622

  3. Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues.

    PubMed

    Padron, Alvaro Souto; Neto, Ruy Andrade Louzada; Pantaleão, Thiago Urgal; de Souza dos Santos, Maria Carolina; Araujo, Renata Lopes; de Andrade, Bruno Moulin; da Silva Leandro, Monique; de Castro, João Pedro Saar Werneck; Ferreira, Andrea Claudia Freitas; de Carvalho, Denise Pires

    2014-06-01

    In general, 3,5-diiodothyronine (3,5-T2) increases the resting metabolic rate and oxygen consumption, exerting short-term beneficial metabolic effects on rats subjected to a high-fat diet. Our aim was to evaluate the effects of chronic 3,5-T2 administration on the hypothalamus-pituitary-thyroid axis, body mass gain, adipose tissue mass, and body oxygen consumption in Wistar rats from 3 to 6 months of age. The rats were treated daily with 3,5-T2 (25, 50, or 75 μg/100 g body weight, s.c.) for 90 days between the ages of 3 and 6 months. The administration of 3,5-T2 suppressed thyroid function, reducing not only thyroid iodide uptake but also thyroperoxidase, NADPH oxidase 4 (NOX4), and thyroid type 1 iodothyronine deiodinase (D1 (DIO1)) activities and expression levels, whereas the expression of the TSH receptor and dual oxidase (DUOX) were increased. Serum TSH, 3,3',5-triiodothyronine, and thyroxine were reduced in a 3,5-T2 dose-dependent manner, whereas oxygen consumption increased in these animals, indicating the direct action of 3,5-T2 on this physiological variable. Type 2 deiodinase activity increased in both the hypothalamus and the pituitary, and D1 activities in the liver and kidney were also increased in groups treated with 3,5-T2. Moreover, after 3 months of 3,5-T2 administration, body mass and retroperitoneal fat pad mass were significantly reduced, whereas the heart rate and mass were unchanged. Thus, 3,5-T2 acts as a direct stimulator of energy expenditure and reduces body mass gain; however, TSH suppression may develop secondary to 3,5-T2 administration.

  4. Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues

    PubMed Central

    Padron, Alvaro Souto; Neto, Ruy Andrade Louzada; Pantaleão, Thiago Urgal; de Souza dos Santos, Maria Carolina; Araujo, Renata Lopes; de Andrade, Bruno Moulin; da Silva Leandro, Monique; de Castro, João Pedro Saar Werneck; Ferreira, Andrea Claudia Freitas; de Carvalho, Denise Pires

    2014-01-01

    In general, 3,5-diiodothyronine (3,5-T2) increases the resting metabolic rate and oxygen consumption, exerting short-term beneficial metabolic effects on rats subjected to a high-fat diet. Our aim was to evaluate the effects of chronic 3,5-T2 administration on the hypothalamus–pituitary–thyroid axis, body mass gain, adipose tissue mass, and body oxygen consumption in Wistar rats from 3 to 6 months of age. The rats were treated daily with 3,5-T2 (25, 50, or 75 μg/100 g body weight, s.c.) for 90 days between the ages of 3 and 6 months. The administration of 3,5-T2 suppressed thyroid function, reducing not only thyroid iodide uptake but also thyroperoxidase, NADPH oxidase 4 (NOX4), and thyroid type 1 iodothyronine deiodinase (D1 (DIO1)) activities and expression levels, whereas the expression of the TSH receptor and dual oxidase (DUOX) were increased. Serum TSH, 3,3′,5-triiodothyronine, and thyroxine were reduced in a 3,5-T2 dose-dependent manner, whereas oxygen consumption increased in these animals, indicating the direct action of 3,5-T2 on this physiological variable. Type 2 deiodinase activity increased in both the hypothalamus and the pituitary, and D1 activities in the liver and kidney were also increased in groups treated with 3,5-T2. Moreover, after 3 months of 3,5-T2 administration, body mass and retroperitoneal fat pad mass were significantly reduced, whereas the heart rate and mass were unchanged. Thus, 3,5-T2 acts as a direct stimulator of energy expenditure and reduces body mass gain; however, TSH suppression may develop secondary to 3,5-T2 administration. PMID:24692290

  5. Unified-planning, graded-administration, and centralized-controlling: a management modality for treating acquired immune deficiency syndrome with Chinese medicine in Henan Province of China.

    PubMed

    Xu, Li-Ran; Guo, Hui-jun; Liu, Zhi-bin; Li, Qiang; Yang, Ji-ping; He, Ying

    2015-04-01

    Henan Province in China has a major epidemic of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). Chinese medicine (CM) has been used throughout the last decade, and a management modality was developed, which can be described by unified-planning, graded-administration, and centralized-controlling (UGC). The UGC modality has one primary concept (patient-centered medicine from CM theory), four basic foundations (classifying administrative region, characteristics of CM on disease treatment, health resource conditions, and distribution of patients living with HIV), six important relationships (the "three uniformities and three combinations," and the six relationships therein guide the treatment of AIDS with CM), and four key sections (management, operation, records, and evaluation). In this article, the authors introduce the UGC modality, which could be beneficial to developing countries or resource-limited areas for the management of chronic infectious disease.

  6. L-arginine abolishes the hypothalamic serotonergic activation induced by central interleukin-1β administration to normal rats

    PubMed Central

    2013-01-01

    IL-1β-induced anorexia may depend on interactions of the cytokine with neuropeptides and neurotransmitters of the central nervous system control of energy balance and serotonin is likely to be one catabolic mediator targeted by IL-1β. In the complex interplay involved in feeding modulation, nitric oxide has been ascribed a stimulatory action, which could be of significance in counteracting IL-1β effects. The present study aims to explore the participation of the nitric oxide and the serotonin systems on the central mechanisms induced by IL-1β and the relevance of their putative interactions to IL-1β hypophagia in normal rats. Serotonin levels were determined in microdialysates of the ventromedial hypothalamus after a single intracerebroventricular injection of 10 ng of IL-1β , with or without the pre-injection of 20 μg of the nitric oxide precursor L-arginine. IL-1β significantly stimulated hypothalamic serotonin extracellular levels, with a peak variation of 130 ±37% above baseline. IL- 1β also reduced the 4-h and the 24-h food intakes (by 23% and 58%, respectively). The IL-1β-induced serotonergic activation was abolished by the pre-injection of L-arginine while the hypophagic effect was unaffected. The data showed that one central effect of IL-1β is serotonergic stimulation in the ventromedial hypothalamus, an action inhibited by nitric oxide activity. It is suggested that, although serotonin participates in IL-1β anorexia, other mechanisms recruited by IL-1β in normal rats are able to override the absence of the serotonergic hypophagic influence. PMID:24314273

  7. Cardiovascular and behavioral effects produced by administration of liposome-entrapped GABA into the rat central nervous system.

    PubMed

    Vaz, G C; Bahia, A P C O; de Figueiredo Müller-Ribeiro, F C; Xavier, C H; Patel, K P; Santos, R A S; Moreira, F A; Frézard, F; Fontes, M A P

    2015-01-29

    Liposomes are nanosystems that allow a sustained release of entrapped substances. Gamma-aminobutyric acid (GABA) is the most prevalent inhibitory neurotransmitter of the central nervous system (CNS). We developed a liposomal formulation of GABA for application in long-term CNS functional studies. Two days after liposome-entrapped GABA was injected intracerebroventricularly (ICV), Wistar rats were submitted to the following evaluations: (1) changes in mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) to ICV injection of bicuculline methiodide (BMI) in anesthetized rats; (2) changes in cardiovascular reactivity to air jet stress in conscious rats; and (3) anxiety-like behavior in conscious rats. GABA and saline-containing pegylated liposomes were prepared with a mean diameter of 200 nm. Rats with implanted cannulas targeted to lateral cerebral ventricle (n = 5-8/group) received either GABA solution (GS), empty liposomes (EL) or GABA-containing liposomes (GL). Following (48 h) central microinjection (2 μL, 0.09 M and 99 g/L) of liposomes, animals were submitted to the different protocols. Animals that received GL demonstrated attenuated response of RSNA to BMI microinjection (GS 48 ± 9, EL 43 ± 9, GL 11 ± 8%; P < 0.05), blunted tachycardia in the stress trial (ΔHR: GS 115 ± 14, EL 117 ± 10, GL 74 ± 9 bpm; P<0.05) and spent more time in the open arms of elevated plus maze (EL 6 ± 2 vs. GL 18 ± 5%; P = 0.028) compared with GS and EL groups. These results indicate that liposome-entrapped GABA can be a potential tool for exploring the chronic effects of GABA in specific regions and pathways of the central nervous system.

  8. Developmental lead exposure induces opposite effects on ethanol intake and locomotion in response to central vs. systemic cyanamide administration.

    PubMed

    Mattalloni, Mara Soledad; Deza-Ponzio, Romina; Albrecht, Paula Alejandra; Cancela, Liliana Marina; Virgolini, Miriam Beatriz

    2017-02-01

    Lead (Pb) is a developmental neurotoxicant that elicits differential responses to drugs of abuse. Particularly, ethanol consumption has been demonstrated to be increased as a consequence of environmental Pb exposure, with catalase (CAT) and brain acetaldehyde (ACD, the first metabolite of ethanol) playing a role. The present study sought to interfere with ethanol metabolism by inhibiting ALDH2 (mitochondrial aldehyde dehydrogenase) activity in both liver and brain from control and Pb-exposed rats as a strategy to accumulate ACD, a substance that plays a major role in the drug's reinforcing and/or aversive effects. To evaluate the impact on a 2-h chronic voluntary ethanol intake test, developmentally Pb-exposed and control rats were administered with cyanamide (CY, an ALDH inhibitor) either systemically or intracerebroventricularly (i.c.v.) on the last 4 sessions of the experiment. Furthermore, on the last session and after locomotor activity was assessed, all animals were sacrificed to obtain brain and liver samples for ALDH2 and CAT activity determination. Systemic CY administration reduced the elevated ethanol intake already reported in the Pb-exposed animals (but not in the controls) accompanied by liver (but not brain) ALDH2 inactivation. On the other hand, a 0.3 mg i.c.v. CY administration enhanced both ethanol intake and locomotor activity accompanied by brain ALDH2 inactivation in control animals, while an increase in ethanol consumption was also observed in the Pb-exposed group, although in the absence of brain ALDH2 blockade. No changes were observed in CAT activity as a consequence of CY administration. These results support the participation of liver and brain ACD in ethanol intake and locomotor activity, responses that are modulated by developmental Pb exposure.

  9. Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice.

    PubMed

    Rodgers, Jean; Bradley, Barbara; Kennedy, Peter G E; Sternberg, Jeremy M

    2015-01-01

    Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ and TNF-α concentrations, CNS parasitosis and ameliorates neuro-inflammatory pathology and clinical symptoms of disease. The results provide evidence that CNS invasion may be susceptible to immunological attenuation.

  10. The thermal state and strength of the lithosphere in the Spanish Central System and Tajo Basin from crustal heat production and thermal isostasy

    NASA Astrophysics Data System (ADS)

    Jiménez-Díaz, Alberto; Ruiz, Javier; Villaseca, Carlos; Tejero, Rosa; Capote, Ramón

    2012-07-01

    In this work we have modeled the thermal structure of the lithosphere of the Spanish Central System and the Tajo Basin, and their implications for lithospheric strength. For this, we have used refined heat-producing elements (HPE) values to obtain new estimates of heat production rates in the Spanish Central System and Tajo Basin areas, which have been used joined to the relation between topography and thermal structure of the lithosphere to calculate the best-fit surface heat flows in the study area. Moreover, we have implemented a temperature-dependent thermal conductivity (appropriate for olivine) for the lithospheric mantle to improve the calculations of temperature profiles in the mantle. The geotherms so obtained, together with the implementation of a new rheological law for the upper lithospheric mantle, have been used to calculate refined estimations of the strength and effective elastic thickness of the lithosphere. We have obtained surface heat flow values of 84 mW m-2 and ˜82 mW m-2 for the Spanish Central System and the Tajo Basin, respectively. The thermal state of the lithosphere affects mantle temperatures, and hence may be playing an important role in the uplift and maintenance of the Spanish Central System.

  11. Central Fos expression and conditioned flavor avoidance in rats following intragastric administration of bitter taste receptor ligands.

    PubMed

    Hao, Shuzhen; Dulake, Michelle; Espero, Elvis; Sternini, Catia; Raybould, Helen E; Rinaman, Linda

    2009-03-01

    G protein-coupled receptors that signal bitter taste (T2Rs) are expressed in the mucosal lining of the oral cavity and gastrointestinal (GI) tract. In mice, intragastric infusion of T2R ligands activates Fos expression within the caudal viscerosensory portion of the nucleus of the solitary tract (NTS) through a vagal pathway (Hao S, Sternini C, Raybould HE. Am J Physiol Regul Integr Comp Physiol 294: R33-R38, 2008). The present study was performed in rats to further characterize the distribution and chemical phenotypes of brain stem and forebrain neurons activated to express Fos after intragastric gavage of T2R ligands, and to determine a potential behavioral correlate of this central neural activation. Compared with relatively low brain stem and forebrain Fos expression in control rats gavaged intragastrically with water, rats gavaged intragastrically with T2R ligands displayed significantly increased activation of neurons within the caudal medial (visceral) NTS and caudal ventrolateral medulla, including noradrenergic neurons, and within the lateral parabrachial nucleus, central nucleus of the amygdala, and paraventricular nucleus of the hypothalamus. A behavioral correlate of this Fos activation was evidenced when rats avoided consuming flavors that previously were paired with intragastric gavage of T2R ligands. While unconditioned aversive responses to bitter tastants in the oral cavity are often sufficient to inhibit further consumption, a second line of defense may be provided postingestively by ligand-induced signaling at GI T2Rs that signal the brain via vagal sensory inputs to the caudal medulla.

  12. Regional Climate Zone Modeling of a Commercial Absorption Heat Pump Hot Water Heater Part 1: Southern and South Central Climate Zones

    SciTech Connect

    Geoghegan, Patrick J; Shen, Bo; Keinath, Christopher M.; Garrabrant, Michael A.

    2016-01-01

    Commercial hot water heating accounts for approximately 0.78 Quads of primary energy use with 0.44 Quads of this amount from natural gas fired heaters. An ammonia-water based commercial absorption system, if fully deployed, could achieve a high level of savings, much higher than would be possible by conversion to the high efficiency nonheat-pump gas fired alternatives. In comparison with air source electric heat pumps, the absorption system is able to maintain higher coefficients of performance in colder climates. The ammonia-water system also has the advantage of zero Ozone Depletion Potential and low Global Warming Potential. A thermodynamic model of a single effect ammonia-water absorption system for commercial space and water heating was developed, and its performance was investigated for a range of ambient and return water temperatures. This allowed for the development of a performance map which was then used in a building energy modeling software. Modeling of two commercial water heating systems was performed; one using an absorption heat pump and another using a condensing gas storage system. The energy and financial savings were investigated for a range of locations and climate zones in the southern and south central United States. A follow up paper will analyze northern and north/central regions. Results showed that the system using an absorption heat pump offers significant savings.

  13. Heat tracing to examine seasonal groundwater flow beneath a low-gradient stream in rural central Illinois, USA

    NASA Astrophysics Data System (ADS)

    Bastola, Hridaya; Peterson, Eric W.

    2016-02-01

    The thermal profile of a streambed is affected by a number of factors including: temperatures of stream water and groundwater, hydraulic conductivity, thermal conductivity, heat capacity of the streambed, and the geometry of hyporheic flow paths. Changes in these parameters over time cause changes in thermal profiles. In this study, temperature data were collected at depths of 30, 60, 90 and 150 cm at six streambed wells 5 m apart along the thalweg of Little Kickapoo Creek, in rural central Illinois, USA. This is a third-order low-gradient baseflow-fed stream. A positive temperature gradient with inflection at 90-cm depth was observed during the summer period. A negative temperature gradient with inflection at 30 cm was observed during the winter period, which suggests greater influence of stream-water temperatures in the substrate during the summer. Thermal models of the streambed were built using VS2DHI to simulate the thermal profiles observed in the field. Comparison of the parameters along with analysis of temperature envelopes and Peclet numbers suggested greater upwelling and stability in temperatures during the winter than during the summer. Upwelling was more pronounced in the downstream reach of the pool in the riffle and pool sequence.

  14. Treatment with a hybrid between the synapsin ABC domains and the B subunit of E. coli heat-labile toxin reduces frequency of proinflammatory cells and cytokines in the central nervous system of rats with EAE.

    PubMed

    Bibolini, M J; Scerbo, M J; Roth, G A; Monferran, C G

    2014-09-26

    Multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), are crucially dependent on the invasion of activated autoreactive lymphocytes and blood macrophages into the central nervous system (CNS). Proinflammatory mononuclear cells and activated local microglia mediate inflammation, demyelination and axonal damage at the target organ. Previously, we observed that the administration of a hybrid between the synapsin ABC domains and the B subunit of Escherichia coli heat labile-enterotoxin (LTBABC) to rats with EAE ameliorated disease by modulating the peripheral Th1 response to myelin basic protein (MBP). In the present study, we investigated the effect of LTBABC administration on proinflammatory cell frequency in the CNS of rats with EAE. Treatment with the hybrid in the inductive phase of EAE attenuated disease severity and diminished histological inflammatory infiltrates and demyelination in the spinal cord of rats with acute EAE. Lower frequencies of infiltrating and local macrophages as well as CD4+ T cells that produce the proinflammatory cytokines interferon-gamma (IFN-γ) and interleukin (IL)-17 were found at the target organ. Concomitantly, low levels of INF-γ and IL-17 and increased levels of IL-10 were measured in cultures of CNS infiltrating cells and spinal cord tissue. An increased frequency of CD4+CD25+Foxp3 cells was observed at the disease peak and at the beginning of the recovery stage. These results provide further evidence for the immunomodulatory properties of the fusion protein LTBABC in autoimmune demyelinating disease affecting the central nervous system.

  15. [Perioperative management of a child with central diabetes insipidus who underwent two surgeries before and after desmopressin administration].

    PubMed

    Kiriyama, Keiji; Tachibana, Kazuya; Nishimura, Nobuyuki; Takeuchi, Muneyuki; Kinouchi, Keiko

    2013-03-01

    A 14-year-old girl weighing 32 kg was diagnosed with suprasellar tumor causing hydrocephalus, hypothyroidism, adrenal dysfunction and central diabetes insipidus. She was treated with levothyroxine and hydrocortisone and urged to take fluid to replace urine. She was scheduled to undergo ventricular drainage to relieve hydrocephalus prior to tumor resection. For the first surgery, desmopressin was not started and urine output reached 4,000 to 6,000 ml x day(-1), urine osmolality 64 mOsm x l(-1) and urine specific gravity 1.002. Anesthesia was induced with sevoflurane and maintained with propofol and remifentanil. Maintenance fluid was with acetated Ringer's solution and urine loss was replaced with 5% dextrose. Bradycardia and hypotension occurred after intubation, which was treated with volume load. Infusion volume was 750 ml and urine output was 1100 ml during 133 min of anesthesia. Postoperative day 1 nasal desmopressin was started. Ten days later, partial tumor resection was performed. Anesthesia was induced with propofol and fentanyl and maintained with sevoflurane and remifentanil. Infusion volume was 610 ml, urine output 380 ml, and blood loss 151 ml during 344 min of anesthesia. Hemodynamic parameters were stable throughout the procedure. Pathology of the tumor was revealed to be germinoma. Bradycardia and hypotension experienced during the first surgery was suspected to be caused by preoperative hypovolemia brought by polyuria. Desmopressin was proved to be effective to treat excessive urine output and to maintain good perioperative water balance.

  16. The influence of vasopressin deficiency and acute desmopressin administration on melatonin secretion in patients with central diabetes insipidus.

    PubMed

    Catrina, S B; Rotarus, R; Wivall, I-L; Coculescu, M; Brismar, K

    2004-01-01

    Melatonin secretion is modulated by the light-dark schedule, mainly through a sympathetic input to the pineal gland. Besides this, arginine vasopressin (AVP) has been found in the pineal glands of several animal species and there is experimental evidence that AVP modulates melatonin secretion in animals. However, the interaction between vasopressin and melatonin secretion in humans has not been systematically investigated. We proposed to study the nocturnal melatonin pattern in patients with central diabetes insipidus (CDI) who lack endogenous secretion of AVP, and the effect on their melatonin secretion of the agonist for V2 type receptors: desmopressin (1-Desamino [8-D Arginine] vasopressin). Plasma melatonin levels were measured in 14 patients with CDI, every 2 h starting from 22:00 h until 06:00 h, following iv injection of saline (day 1) and 3 microg desmopressin (day 2) at 20:00 h. The lights were turned off at 22:30 h and the samples were taken in a dim light. The plasma melatonin secretion pattern was normal in patients with CDI. Desmopressin at a dose 3 times higher than the antidiuretic one did not modify the melatonin levels or the time of the peak secretion. In conclusion melatonin secretion is not modulated by AVP in humans.

  17. High-dose methotrexate following intravitreal methotrexate administration in preventing central nervous system involvement of primary intraocular lymphoma.

    PubMed

    Akiyama, Hiroki; Takase, Hiroshi; Kubo, Fumito; Miki, Tohru; Yamamoto, Masahide; Tomita, Makoto; Mochizuki, Manabu; Miura, Osamu; Arai, Ayako

    2016-10-01

    In order to prevent central nervous system (CNS) involvement and improve the prognosis of primary intraocular lymphoma (PIOL), we prospectively evaluated the efficacy of combined therapy using intravitreal methotrexate (MTX) and systemic high-dose MTX on treatment-naïve PIOL. Patients with newly diagnosed PIOL whose lymphoma was limited to the eyes were enrolled. The patients were treated with weekly intravitreal MTX until the ocular lesions were resolved, followed by five cycles of systemic high-dose MTX (3.5 g/m(2) ) every other week. Ten patients were enrolled in this study and completed the treatment. All patients achieved complete response for their ocular lesions with rapid decrease of intravitreal interleukin-10 concentration. Adverse events of intravitreal and systemic high-dose MTX were mild and tolerable. With a median follow-up of 29.5 months, four patients (40%) experienced the CNS disease development and the mean CNS lymphoma-free survival (CLFS) time was 51.1 months. Two-year CLFS, which was the primary end-point of the study, was 58.3% (95% confidence interval, 23.0-82.1%). In contrast, eight patients were treated with intravitreal MTX alone in our institute, and their 2-year CLFS was 37.5% (95% confidence interval, 8.7-67.4%). In conclusion, systemic high-dose MTX following intravitreal MTX is feasible and might be effective in preventing CNS involvement of PIOL. Further arrangements are worth considering in order to improve the effects. This study was registered with UMIN Clinical Trials Registry (UMIN000003921).

  18. Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models

    PubMed Central

    O’Neill, Jessica; Sikandar, Shafaq; McMahon, Stephen B; Dickenson, Anthony H

    2015-01-01

    Abstract The predictive value of laboratory models for human pain processing is crucial for improving translational research. The discrepancy between peripheral and central mechanisms of pain is an important consideration for drug targets, and here we describe two models of inflammatory pain that involve ultraviolet B (UVB) irradiation, which can employ peripheral and central sensitisation to produce mechanical and thermal hyperalgesia in rats and humans. We use electrophysiology in rats to measure the mechanically- and thermally-evoked activity of rat spinal neurones and quantitative sensory testing to assess human psychophysical responses to mechanical and thermal stimulation in a model of UVB irradiation and in a model of UVB irradiation with heat rekindling. Our results demonstrate peripheral sensitisation in both species driven by UVB irradiation, with a clear mechanical and thermal hypersensitivity of rat dorsal horn neurones and enhanced perceptual responses of human subjects to both mechanical and thermal stimulation. Additional heat rekindling produces markers of central sensitisation in both species, including enhanced receptive field sizes. Importantly, we also showed a correlation in the evoked activity of rat spinal neurones to human thermal pain thresholds. The parallel results in rats and humans validate the translational use of both models and the potential for such models for preclinical assessment of prospective analgesics in inflammatory pain states. Key points Translational research is key to bridging the gaps between preclinical findings and the patients, and a translational model of inflammatory pain will ideally induce both peripheral and central sensitisation, more effectively mimicking clinical pathophysiology in some chronic inflammatory conditions. We conducted a parallel investigation of two models of inflammatory pain, using ultraviolet B (UVB) irradiation alone and UVB irradiation with heat rekindling. We used rodent electrophysiology

  19. Human psychophysics and rodent spinal neurones exhibit peripheral and central mechanisms of inflammatory pain in the UVB and UVB heat rekindling models.

    PubMed

    O'Neill, Jessica; Sikandar, Shafaq; McMahon, Stephen B; Dickenson, Anthony H

    2015-09-01

    Translational research is key to bridging the gaps between preclinical findings and the patients, and a translational model of inflammatory pain will ideally induce both peripheral and central sensitisation, more effectively mimicking clinical pathophysiology in some chronic inflammatory conditions. We conducted a parallel investigation of two models of inflammatory pain, using ultraviolet B (UVB) irradiation alone and UVB irradiation with heat rekindling. We used rodent electrophysiology and human quantitative sensory testing to characterise nociceptive processing in the peripheral and central nervous systems in both models. In both species, UVB irradiation produces peripheral sensitisation measured as augmented evoked activity of rat dorsal horn neurones and increased perceptual responses of human subjects to mechanical and thermal stimuli. In both species, UVB with heat rekindling produces central sensitisation. UVB irradiation alone and UVB with heat rekindling are translational models of inflammation that produce peripheral and central sensitisation, respectively. The predictive value of laboratory models for human pain processing is crucial for improving translational research. The discrepancy between peripheral and central mechanisms of pain is an important consideration for drug targets, and here we describe two models of inflammatory pain that involve ultraviolet B (UVB) irradiation, which can employ peripheral and central sensitisation to produce mechanical and thermal hyperalgesia in rats and humans. We use electrophysiology in rats to measure the mechanically- and thermally-evoked activity of rat spinal neurones and quantitative sensory testing to assess human psychophysical responses to mechanical and thermal stimulation in a model of UVB irradiation and in a model of UVB irradiation with heat rekindling. Our results demonstrate peripheral sensitisation in both species driven by UVB irradiation, with a clear mechanical and thermal hypersensitivity of

  20. Heat pumps

    NASA Astrophysics Data System (ADS)

    Gilli, P. V.

    1982-11-01

    Heat pumps for residential/commercial space heating and hot tap water make use of free energy of direct or indirect solar heat and save from about 40 to about 70 percent of energy if compared to a conventional heating system with the same energy basis. In addition, the electrically driven compressor heat pump is able to substitute between 40% (bivalent alternative operation) to 100% (monovalent operation) of the fuel oil of an oilfired heating furnace. For average Central European conditions, solar space heating systems with high solar coverage factor show the following sequence of increasing cost effectiveness: pure solar systems (without heat pumps); heat pump assisted solar systems; solar assisted heat pump systems; subsoil/water heat pumps; air/water heat pumps; air/air heat pumps.

  1. Regional relation between skin blood flow and sweating to passive heating and local administration of acetylcholine in young, healthy humans

    PubMed Central

    Kenney, W. Larry; Alexander, Lacy M.

    2013-01-01

    Regional variation in sweating over the human body is widely recognized yet variation in vasomotor responses and mechanisms causing this variation remain unclear. This study aimed to explore the relation between regional sweating rates (RSR) and skin blood flow (SkBF) responses to thermal and pharmacological stimuli in young, healthy subjects. In nine subjects (23 ± 3 yr), intradermal microdialysis (MD) probes were inserted into the ventral forearm, abdomen, thigh, and lower back and perfused with lactated Ringer solution. RSR over each MD membrane were measured using ventilated capsules with a laser Doppler probe housed in each capsule for measurement of red cell flux (laser Doppler flux, LDF) as an index of SkBF. Subjects completed a whole body heating protocol to 1°C rise in oral temperature and an acetylcholine dose response (ACh 1 × 10−7-0.1 M; mean skin temperature 34°C). Maximal LDF were obtained at the end of both protocols (50 mM sodium nitroprusside).During heating RSR varied among sites (P < 0.0001) and was greater on the back versus other sites (P < 0.05), but LDF was similar between sites (P = 0.343). RSR and SkBF showed a strong relation during initial (arm: r = 0.77 ± 0.09, thigh: r = 0.81 ± 0.08, abdomen: r = 0.89 ± 0.04, back: r = 0.86 ± 0.04) but not latter stages of heating. No differences in RSR (P = 0.160) or SkBF (LDF, P = 0.841) were observed between sites during ACh perfusion. Taken together, these data suggest that increases in SkBF are necessary to initiate and increase sweating, but further rises in RSR are not fully dependent on SkBF in a dose-response manner. Furthermore, RSR cannot be explained by cholinergic sensitivity or variation in SkBF. PMID:23389110

  2. Central administration of oxytocin differentially increases yawning, penile erections and scratching in high- (HY) and low-yawning (LY) sublines of Sprague-Dawley rats.

    PubMed

    Eguibar, Jose R; Cortes, Carmen; Isidro, O; Ugarte, A

    2015-07-01

    Central administration of oxytocin has been shown to induce yawning, penile erection, grooming and scratching. Yawning and penile erections are due to activation of oxytocinergic neurons in the paraventricular nucleus of the hypothalamus. We selectively bred two sublines from Sprague-Dawley rats, one with a high-yawning frequency (HY) of 20yawns/h, and one with a low-yawning (LY) frequency of 2yawns/h. The aim of the current study was to analyze the behavioral effects of centrally-administered oxytocin [15ng-10μg; intracerebroventricularly (i.c.v.)] on yawning, penile erections, grooming and scratching in adult male rats from both sublines. Oxytocin produced a dose-dependent increase in yawning and penile erection frequencies and this effect was significantly higher in the HY, compared to the LY, subline. However, the number of oxytocin-induced scratching bouts was significantly higher in the LY, compared to the HY group. In conclusion, these sublines represent a suitable model for detailed analysis of behavior induced by oxytocin and other neuropeptides in animals with different spontaneous expression of behavioral traits.

  3. Effects of the Oral Administration of Viable and Heat-Killed Streptococcus bovis HC5 Cells to Pre-Sensitized BALB/c Mice

    PubMed Central

    Paiva, Aline D.; Fernandes, Kenner M.; Dias, Roberto S.; Rocha, Alípio S.; de Oliveira, Leandro L.; Neves, Clóvis A.; de Paula, Sérgio O.; Mantovani, Hilário C.

    2012-01-01

    Antimicrobial peptides have been suggested as an alternative to classical antibiotics in livestock production and bacteriocin-producing bacteria could be added to animal feeds to deliver bacteriocins in the gastrointestinal (GI) tract of ruminant and monogastric animals. In this study, viable (V) and heat-killed (HK) Streptococcus bovis HC5 cells were orally administered to pre-sensitized mice in order to assess the effects of a bacteriocin-producing bacteria on histological parameters and the immune response of the GI tract of monogastric animals. The administration of V and HK S. bovis HC5 cells during 58 days to BALB/c mice did not affect weight gain, but an increase in gut permeability was detected in animals receiving the HK cells. Viable and heat killed cells caused similar morphological alterations in the GI tract of the animals, but the most prominent effects were detected in the small intestine. The oral administration of S. bovis HC5 also influenced cytokine production in the small intestine, and the immune-mediated activity differed between V and HK cells. The relative expression of IL-12 and INF-γ was significantly higher in the small intestine of mice treated with V cells, while an increase in IL-5, IL-13 and TNF-α expression was only detected in mice treated with HK cells. Considering that even under a condition of severe challenge (pre-sensitization followed by daily exposure to the same bacterial immunogen) the general health of the animals was maintained, it appears that oral administration of S. bovis HC5 cells could be a useful route to deliver bacteriocin in the GI tract of livestock animals. PMID:23144752

  4. Effects of the oral administration of viable and heat-killed Streptococcus bovis HC5 cells to pre-sensitized BALB/c mice.

    PubMed

    Paiva, Aline D; Fernandes, Kenner M; Dias, Roberto S; Rocha, Alípio S; de Oliveira, Leandro L; Neves, Clóvis A; de Paula, Sérgio O; Mantovani, Hilário C

    2012-01-01

    Antimicrobial peptides have been suggested as an alternative to classical antibiotics in livestock production and bacteriocin-producing bacteria could be added to animal feeds to deliver bacteriocins in the gastrointestinal (GI) tract of ruminant and monogastric animals. In this study, viable (V) and heat-killed (HK) Streptococcus bovis HC5 cells were orally administered to pre-sensitized mice in order to assess the effects of a bacteriocin-producing bacteria on histological parameters and the immune response of the GI tract of monogastric animals. The administration of V and HK S. bovis HC5 cells during 58 days to BALB/c mice did not affect weight gain, but an increase in gut permeability was detected in animals receiving the HK cells. Viable and heat killed cells caused similar morphological alterations in the GI tract of the animals, but the most prominent effects were detected in the small intestine. The oral administration of S. bovis HC5 also influenced cytokine production in the small intestine, and the immune-mediated activity differed between V and HK cells. The relative expression of IL-12 and INF-γ was significantly higher in the small intestine of mice treated with V cells, while an increase in IL-5, IL-13 and TNF-α expression was only detected in mice treated with HK cells. Considering that even under a condition of severe challenge (pre-sensitization followed by daily exposure to the same bacterial immunogen) the general health of the animals was maintained, it appears that oral administration of S. bovis HC5 cells could be a useful route to deliver bacteriocin in the GI tract of livestock animals.

  5. Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates the development of dermatitis and inhibits immunoglobulin E production in atopic dermatitis model NC/Nga mice.

    PubMed

    Segawa, Shuichi; Hayashi, Atsushi; Nakakita, Yasukazu; Kaneda, Hirotaka; Watari, Junji; Yasui, Hisako

    2008-05-01

    We have previously shown that the oral administration of heat-killed Lactobacillus brevis (L. brevis) SBC8803 strain inhibits IgE production in ovalbumin (OVA)-sensitized BALB/c mice through improvement of the type-1 helper T (Th1)/Th2 balance toward Th1 dominance. Atopic dermatitis is one of the most common skin diseases and is frequently associated with elevated immunoglobulin E (IgE) antibodies against many kinds of allergens. In this study, we investigated the inhibitory effect of oral administration of L. brevis SBC8803 on the development of dermatitis and IgE elevation using the NC/Nga atopic dermatitis model mice. Male 8-week-old NC/Nga mice were sensitized by the topical application of picryl chloride to foot pads and shaved abdomen. These mice were boosted with picryl chloride by topical application onto the ears once a week for 9 weeks. The mice (n=10 per group) were fed a diet containing 0%, 0.05% or 0.5% of heat-killed L. brevis SBC8803 from 2 weeks before the first sensitization to the end of the study. Total IgE concentration in serum, clinical score, and ear thickness were periodically examined throughout the study. Finally, cytokine (interleukin (IL)-4, IL-5, IL-6, IL-10, IL-12, IFN-gamma and transforming growth factor (TGF)-beta) productions from splenocytes and Peyer's patch (PP) cells of mice were measured. Oral administration of L. brevis SBC8803 significantly inhibited IgE production and ear swelling, and suppressed the development of dermatitis in a dose-dependent manner. Immunosuppressive cytokines such as IL-10 and TGF-beta production from PP cells significantly increased in the 0.5% group compared to the control group although Th1-type and Th2-type cytokines production was not affected.

  6. Additional cooling and heating load improvements in seasonal performance modeling of room and central air conditioners and heat pumps. Topical report, Subtask 3. 2

    SciTech Connect

    Not Available

    1980-04-09

    The study focuses on improving the load modeling technique of Seasonal Performance Model (SPM) in order to estimate a more realistic load for seasonal analysis calculations on an hourly basis. A computer simulation program, Seasonal Performance Model Load (SPMLD), was used to calculate the cooling and heating loads for a typical residence in Caribou, Maine; Columbia, Missouri; and Fort Worth, Texas. The derivation of the SPMLD is described and changes made to improve cooling and heating load estimates are identified. (MCW)

  7. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: Role of the ventral tegmental area and central nucleus of the amygdala

    PubMed Central

    Kenny, Paul J.; Chartoff, Elena; Roberto, Marisa; Carlezon, William A.; Markou, Athina

    2009-01-01

    Nicotine is considered an important component of tobacco responsible for the smoking habit in humans. Nicotine increases glutamate-mediated transmission throughout brain reward circuitries. This action of nicotine could potentially contribute to its intrinsic rewarding and reward-enhancing properties, which motivate consumption of the drug. Here we show that the competitive N-methyl-D-aspartate (NMDA) receptor antagonist LY235959 (0.5–2.5 mg/kg) abolished nicotine-enhanced brain reward function, reflected in blockade of the lowering of intracranial self-stimulation (ICSS) thresholds usually observed after experimenter-administered (0.25 mg/kg) or intravenously self-administered (0.03 mg/kg/infusion) nicotine injections. The highest LY235959 dose (5 mg/kg) tested reversed the hedonic valence of nicotine from positive to negative, reflected in nicotine-induced elevations of ICSS thresholds. LY235959 doses that reversed nicotine-induced lowering of ICSS thresholds also markedly decreased nicotine self-administration without altering responding for food reinforcement, whereas the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist NBQX had no effects on nicotine intake. In addition, nicotine self-administration upregulated NMDA receptor subunit expression in the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA), suggesting important interactions between nicotine and the NMDA receptor. Furthermore, nicotine (1 μM) increased NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in rat CeA slices, similar to its previously described effects in the VTA. Finally, infusion of LY235959 (0.1–10 ng/side) into the CeA or VTA decreased nicotine self-administration. Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug. PMID:18418357

  8. Use of Sandia's Central Receiver Test Facility as a high-intensity heat source for testing missile nose-cone (Radome) radar systems

    SciTech Connect

    Porter, D.R.

    1981-09-01

    A series of tests at Sandia's Central Receiver Test Facility in support of the US Navy's SM-2 Blk 2 Radome Improvement Program is described. The CRTF was the source of high-intensity solar radiation for testing onboard radar-tracking systems under heating conditions intended to simulate those that occur in supersonic flight. Also discussed are the hardware used and the software developed at the CRTF.

  9. Estimating and interpretation of radioactive heat production using airborne gamma-ray survey data of Gabal Arrubushi area, Central Eastern Desert, Egypt

    NASA Astrophysics Data System (ADS)

    Youssef, Mohamed A. S.

    2016-02-01

    The present work deals with mapping of radioactive heat production from rocks in the Gabal Arrubushi area in the Central Eastern Desert of Egypt based on airborne spectral gamma-ray survey data. The results show that the radioactive heat production in the areas ranges from 0.01 μWm-3 to 5.2 μWm-3. Granites, muscovite and sericite schists in the western part of Gabal Arrubushi area have abnormally high radioactive heat production values from 2.57 μWm-3 to 4.44 μWm-3. Meanwhile, the higher averages of radioactive heat production of these rock units change from 1.21 μWm-3 to 1.5 μWm-3. The intermediate averages of heat production of felsitic mylonite schist, chlorite schist, felsites, amphibolites and Hammamat sediments are below the crustal average value range, i.e., from 0.8 μWm-3 to 1.2 μWm-3. The lowest averages of heat production values are less than 0.8 μWm-3 and found in the following rock units: Wadi sediments, rhyolites, andesites, gabbro and serpentinites.

  10. Oral administration of heat-inactivated Mycobacterium bovis reduces the response of farmed red deer to avian and bovine tuberculin.

    PubMed

    López, Vladimir; González-Barrio, David; Lima-Barbero, José Francisco; Ortiz, José Antonio; Domínguez, Lucas; Juste, Ramón; Garrido, Joseba M; Sevilla, Iker A; Alberdi, Pilar; de la Fuente, José; Gortázar, Christian

    2016-04-01

    Orally delivered mycobacterial antigens may not sensitize the immunized animals causing a positive tuberculin skin test response. As the first step to address this critical issue, we characterized the response of farmed red deer (Cervus elaphus) to orally delivered heat-inactivated Mycobacterium bovis. Thirty-two adult red deer hinds from a farm known to be free of tuberculosis (TB) were randomly assigned to two different treatment groups, immunized (n=24) and control (n=8). Immunized hinds were dosed orally with 2 ml of PBS containing 6 × 10(6) heat-inactivated M. bovis. The mean skin test response of immunized deer to both avian purified protein derivative (aPPD) and bovine PPD (bPPD) was consistently lower in immunized than in control hinds. One year after immunization, immunized hinds had a significant reduction in the skin test response to aPPD and in the ELISA antibody levels against both aPPD and bPPD (24-36% reduction; P<0.05). By contrast, no significant change was observed in the skin test response to phytohaemagglutinin, or in the ELISA antibody levels against the M. bovis specific antigen MPB70. The mRNA levels for C3, IFN-γ and IL-1β and serum protein levels for IFN-γ and IL-1β did not vary between immunized and control deer. However, serum C3 protein levels were significantly higher (P=0.001) in immunized than in control deer six months after immunization. These results confirm that oral heat-inactivated M. bovis does not sensitize farmed red deer and therefore does not cause false-positive responses in the tuberculin skin test. The absence of sensitization in orally immunized deer opens the possibility of testing the vaccine in deer and possibly other ruminants without the risk of causing false-positive reactions in TB-tests. This study also provided the first evidence that orally-delivered inactivated mycobacterial antigens elicit some kind of immune response in a ruminant.

  11. Effect of Ducted HPWH on Space-Conditioning and Water Heating Energy Use -- Central Florida Lab Home

    SciTech Connect

    Colon, Carlos; Martin, Eric; Parker, Danny

    2016-11-01

    The purpose of this research is to investigate the impact of ducted heat pump water heaters (HPWH's) on space conditioning and water heating energy use in residential applications. Two identical HPWH's, each of 60 gallon capacity were tested side by side at the Flexible Residential Test facility (FRTF) laboratories of the Florida Solar Energy Center (FSEC) campus in Cocoa, Florida. The water heating experiments were run in each test house from July 2014 until February 2015.

  12. Oral Administration of Heat-Killed Mycobacterium manresensis Delays Progression toward Active Tuberculosis in C3HeB/FeJ Mice

    PubMed Central

    Cardona, Paula; Marzo-Escartín, Elena; Tapia, Gustavo; Díaz, Jorge; García, Vanessa; Varela, Ismael; Vilaplana, Cristina; Cardona, Pere-Joan

    2016-01-01

    Low-dose tolerance using heat-killed mycobacteria has been tested as a means of stopping progression toward active tuberculosis (TB) lesions in a human-like murine model using C3HeB/FeJ mice. In the present study, we studied the effect of different treatment schedules with heat-killed non-tuberculous-mycobacteria (NTM) species when given orally, based on the hypothesis of generating oral tolerance. This study included M. manresensis, a new species belonging to the fortuitum group, present in drinking water. Oral treatment with M. manresensis for 2 weeks was able to induce a PPD-specific Tregs population, which has been related to a decrease in the neutrophilic infiltration found in TB lesions. Further mechanistic analysis using PPD-stimulated splenocytes links this 2-week treatment with heat-killed M. manresensis to IL-10 production and memory PPD-specific Tregs, and also to a weak PPD-specific global immune response stimulation, increasing IL-6, TNF, and IFN-γ production. In lungs, this treatment decreased the bacillary load, granulomatous infiltration and pro-inflammatory cytokines (TNF, IFN-γ, IL-6, and IL-17). Oral administration of M. manresensis during standard treatment for TB also significantly reduced the relapse of active TB after ending the treatment. Overall the data suggest that the use of heat-killed M. manresensis could be a new and promising tool for avoiding active TB induction and as adjunctive to TB treatment. This supports the usefulness of generating a new kind of protection based on a complex balanced immune response focused on both destroying the bacilli and including control of an excessive inflammatory response. PMID:26779140

  13. Thermal basin modelling of the Arauco forearc basin, south central Chile — Heat flow and active margin tectonics

    NASA Astrophysics Data System (ADS)

    Kuhn, Philipp P.; Echtler, Helmut; Littke, Ralf; Alfaro, Guillermo

    2010-11-01

    The Arauco basin is part of the coastal forearc domain in South-Central Chile. During its evolution since the Late Cretaceous it was subject to multiple deposition cycles and the erosion of lower bathyal to beach and lagoon sediments. These different environments were established in alternating accretional and erosive subduction tectonic settings along the South Andean active margin. Whereas the general development is well understood, inconsistencies arise regarding the origin of the high thermal maturity of Eocene coals and the estimates of vertical movements of the whole area during the Cenozoic. Thermal modelling of this forearc basin provides new insights regarding its thermal evolution and evaluation of the magnitudes of subsidence and inversion. Results are based on the analysis of coal samples from surface outcrops, mines and drill cores of ten onshore wells from ENAP/Sipetrol. Newly derived vitrinite reflectance (VR r) measurements indicated a temperature in the range of 135-150 °C for the oldest sediment unit of the Arauco basin, which was reached in post Eocene times. Furthermore, 1D basin modelling techniques indicate scenarios that could explain the coalification values in the basin's sediments. The models were calibrated against VR r data from drill core samples supplied by ENAP/Sipetrol. A Miocene and an Oligocene subsidence/inversion scenario were considered, while neither could be securely discarded based on the modelling results. Furthermore, it can be shown that the current thermal maturity was not reached by an increased heat flow (HF) or a deep subsidence only. Consequently, a structural inversion accompanied by the erosion of ~ 3.0 ± 0.4 km depending on the locality in combination with a high HF of ~ 64 ± 4 mW/m 2 is the best explanation of the available data. The HF, which is high for a forearc setting, can be attributed to the increased temperature of the relatively young subducted Nazca Plate and an additional influence of ascending hot

  14. Oral administration of heat-killed Lactobacillus kunkeei YB38 improves murine influenza pneumonia by enhancing IgA production.

    PubMed

    Asama, Takashi; Uematsu, Takayuki; Kobayashi, Noritada; Tatefuji, Tomoki; Hashimoto, Ken

    2017-01-01

    Influenza is one of the important respiratory tract infections that require special attention for maintaining health and hygiene. The removal of influenza virus (IFV) by secretory IgA produced by the respiratory epithelium has been reported to be a critical host defense mechanism. Therefore, we isolated Lactobacillus kunkeei YB38 (YB38), the promoter of the salivary IgA secretion in humans, from honeybee pollen and studied the effect of heat-killed YB38 treatment for preventing IFV infection in a mouse model. Female BALB/c mice received YB38 orally for 21 consecutive days and were then inoculated nasally with IFV. The YB38-treated group with a daily dose of 100 mg/kg showed an increased survival rate after IFV infection relative to the control. IgA secretion in the respiratory epithelium in the YB38-treated group (100 mg/kg) was significantly increased after 6 days of infection, while IL-6 production in the same respiratory site and the number of cells infiltrating into alveoli were significantly decreased. Moreover, lung tissue damage that appeared after IFV infection was reduced. These results suggested that the YB38 dose induced early and local IgA secretion at the infection site, inhibited persistent IFV infection, and prevented the infiltration of inflammatory immune cells or production of excessive IL-6, resulting in less damage to lung tissues.

  15. Oral administration of heat-killed Lactobacillus kunkeei YB38 improves murine influenza pneumonia by enhancing IgA production

    PubMed Central

    ASAMA, Takashi; UEMATSU, Takayuki; KOBAYASHI, Noritada; TATEFUJI, Tomoki; HASHIMOTO, Ken

    2016-01-01

    Influenza is one of the important respiratory tract infections that require special attention for maintaining health and hygiene. The removal of influenza virus (IFV) by secretory IgA produced by the respiratory epithelium has been reported to be a critical host defense mechanism. Therefore, we isolated Lactobacillus kunkeei YB38 (YB38), the promoter of the salivary IgA secretion in humans, from honeybee pollen and studied the effect of heat-killed YB38 treatment for preventing IFV infection in a mouse model. Female BALB/c mice received YB38 orally for 21 consecutive days and were then inoculated nasally with IFV. The YB38-treated group with a daily dose of 100 mg/kg showed an increased survival rate after IFV infection relative to the control. IgA secretion in the respiratory epithelium in the YB38-treated group (100 mg/kg) was significantly increased after 6 days of infection, while IL-6 production in the same respiratory site and the number of cells infiltrating into alveoli were significantly decreased. Moreover, lung tissue damage that appeared after IFV infection was reduced. These results suggested that the YB38 dose induced early and local IgA secretion at the infection site, inhibited persistent IFV infection, and prevented the infiltration of inflammatory immune cells or production of excessive IL-6, resulting in less damage to lung tissues. PMID:28243545

  16. Effect of Change of Aging Heat Treatment Pattern on the JK2LB Jacket for the ITER Central Solenoid

    NASA Astrophysics Data System (ADS)

    Ozeki, Hidemasa; Saito, Toru; Kawano, Katsumi; Takahashi, Yoshikazu; Nunoya, Yoshihiko; Yamazaki, Toru; Isono, Takaaki

    Following the recent improvement of the heat treatment pattern for the ITER CS conductor from 250 hour at 650 °C to 250 hour at 570 °C and then 100 hour at 650 °C, the mechanical properties at 4K and the material structure of the conductor jacketmade of JK2LB after heat treatment including the 570 °C phasewere studied. The mechanical test results at 4K showed no noticeable difference with the jacket heat-treated only at 650 °C to the one additionally heat-treatedat 570 °C.Both satisfied the ITER requirement. The metallographic test results also did not show large difference. In conclusion the 570 °C step does not affect noticeably the JK2LB jacket and the improved heat treatment pattern is applicable.

  17. Heat Stress-Induced PI3K/mTORC2-Dependent AKT Signaling Is a Central Mediator of Hepatocellular Carcinoma Survival to Thermal Ablation Induced Heat Stress

    PubMed Central

    Thompson, Scott M.; Callstrom, Matthew R.; Jondal, Danielle E.; Butters, Kim A.; Knudsen, Bruce E.; Anderson, Jill L.; Lien, Karen R.; Sutor, Shari L.; Lee, Ju-Seog; Thorgeirsson, Snorri S.; Grande, Joseph P.; Roberts, Lewis R.; Woodrum, David A.

    2016-01-01

    Thermal ablative therapies are important treatment options in the multidisciplinary care of patients with hepatocellular carcinoma (HCC), but lesions larger than 2–3 cm are plagued with high local recurrence rates and overall survival of these patients remains poor. Currently no adjuvant therapies exist to prevent local HCC recurrence in patients undergoing thermal ablation. The molecular mechanisms mediating HCC resistance to thermal ablation induced heat stress and local recurrence remain unclear. Here we demonstrate that the HCC cells with a poor prognostic hepatic stem cell subtype (Subtype HS) are more resistant to heat stress than HCC cells with a better prognostic hepatocyte subtype (Subtype HC). Moreover, sublethal heat stress rapidly induces phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dependent-protein kinase B (AKT) survival signaling in HCC cells in vitro and at the tumor ablation margin in vivo. Conversely, inhibition of PI3K/mTOR complex 2 (mTORC2)-dependent AKT phosphorylation or direct inhibition of AKT function both enhance HCC cell killing and decrease HCC cell survival to sublethal heat stress in both poor and better prognostic HCC subtypes while mTOR complex 1 (mTORC1)-inhibition has no impact. Finally, we showed that AKT isoforms 1, 2 and 3 are differentially upregulated in primary human HCCs and that overexpression of AKT correlates with worse tumor biology and pathologic features (AKT3) and prognosis (AKT1). Together these findings define a novel molecular mechanism whereby heat stress induces PI3K/mTORC2-dependent AKT survival signaling in HCC cells and provide a mechanistic rationale for adjuvant AKT inhibition in combination with thermal ablation as a strategy to enhance HCC cell killing and prevent local recurrence, particularly at the ablation margin. PMID:27611696

  18. Oral administration of heat-killed Lactobacillus brevis SBC8803 ameliorates alcoholic liver disease in ethanol-containing diet-fed C57BL/6N mice.

    PubMed

    Segawa, Shuichi; Wakita, Yoshihisa; Hirata, Hiroshi; Watari, Junji

    2008-12-10

    We examined the effect of heat-killed Lactobacillus brevis (L. brevis) SBC8803 on the development of alcoholic liver disease using ethanol-containing diet-fed mice. Heat-killed L. brevis was orally administered at a dose of 100 or 500 mg/kg once a day for 35 days. Alcoholic liver injury was examined by measuring the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in a serum, and the alcoholic fatty liver was assessed from the content of triglyceride (TG) and total cholesterol in the liver. Quantitative RT-PCR was used to examine mRNA expression of tumor necrosis factor (TNF)-alpha, sterol regulatory element-binding protein (SREBP)-1, SREBP-2, and peroxisome proliferator-activated receptor alpha (PPARalpha) in the liver, as well as E-cadherin, Zonula occludens 1 (ZO-1), and heat shock protein (Hsp) 25 in the small intestine. Oral administration of L. brevis significantly inhibited an increase in the level of serum ALT and AST, as well as the content of TG and total cholesterol in the liver caused by ethanol intake. L. brevis supplementation suppressed the overexpression of TNF-alpha, SREBP-1, and SREBP-2 mRNA in the liver induced by ethanol intake and up-regulated the expression of Hsp25 mRNA in the small intestine. These results suggest that L. brevis ameliorated the ethanol-induced liver injury and the fatty liver by suppressing the up-regulation of TNF-alpha and SREBPs in the liver. We speculate that the inhibition of TNF-alpha and SREBPs up-regulation by L. brevis is due to the inhibition of gut-derived endotoxin migration into the liver through the enhancement of intestinal barrier function by the induction of cytoprotective Hsps.

  19. Screening and life-cycle cost models for new pulverized-coal heating plants: An integrated computer-based module for the central heating plant economic evaluation program (CHPECON). Final report

    SciTech Connect

    Sheng, R.; Kinast, J.A.; Biederman, R.; Blazek, C.F.; Lin, M.C.

    1995-07-01

    Public Law 99-190 requires the Department of Defense (DOD) to increase the use of coal for steam generation, but DOD also has an obligation to use the most economical fuel. In support of the coal conversion effort, the U.S. Army Construction Engineering Research Laboratories (USACERL) has been tasked to develop a series of screening and life-cycle cost models to determine when and where specific coal-combustion technologies can economically be implemented in Army central heating plants. This report documents a pulverized coal-fired boiler analysis model, part of the USACERL-developed Central Heating Plant Economics model (CHPECON). The model is divided into two parts. A preliminary screening model contains options for evaluating new heating plants and cogeneration facilities fueled with pulverized coal, as well as the previous options. A cost model uses the entries provided by the screening model to provide a conceptual facility design, capital (installed) costs of the facility, operation and maintenance costs over the life of the facility, and life-cycle costs. Using these numbers the model produces a summary value for the total life-cycle cost of the plant, and a levelized cost of service.

  20. Small heat-shock proteins and leaf cooling capacity account for the unusual heat tolerance of the central spike leaves in Agave tequilana var. Weber.

    PubMed

    Luján, Rosario; Lledías, Fernando; Martínez, Luz María; Barreto, Rita; Cassab, Gladys I; Nieto-Sotelo, Jorge

    2009-12-01

    Agaves are perennial crassulacean acid metabolism (CAM) plants distributed in tropical and subtropical arid environments, features that are attractive for studying the heat-shock response. In agaves, the stress response can be analysed easily during leaf development, as they form a spirally shaped rosette, having the meristem surrounded by folded leaves in the centre (spike) and the unfolded and more mature leaves in the periphery. Here, we report that the spike of Agave tequilana is the most thermotolerant part of the rosette withstanding shocks of up to 55 degrees C. This finding was inconsistent with the patterns of heat-shock protein (Hsp) gene expression, as maximal accumulation of Hsp transcripts was at 44 degrees C in all sectors (spike, inner, middle and outer). However, levels of small HSP (sHSP)-CI and sHSP-CII proteins were conspicuously higher in spike leaves at all temperatures correlating with their thermotolerance. In addition, spike leaves showed a higher stomatal density and abated more efficiently their temperature several degrees below that of air. We propose that the greater capacity for leaf cooling during the day in response to heat stress, and the elevated levels of sHSPs, constitute part of a set of strategies that protect the SAM and folded leaves of A. tequilana from high temperatures.

  1. Nasal administration of an angiotensin antagonist in the rat model: effect of bioadhesive formulations on the distribution of drugs to the systemic and central nervous systems.

    PubMed

    Charlton, S T; Davis, S S; Illum, L

    2007-06-29

    The effect of bioadhesive formulations on the direct transport of an angiotensin antagonist drug ((14)C-GR138950) from the nasal cavity to the central nervous system was evaluated in a rat model. Three different bioadhesive polymer formulations (3% pectin LM-5, 1.0% pectin LM-12 and 0.5% chitosan G210) containing the drug were administered nasally to rats by inserting a dosing cannula 7mm into the nasal cavity after which the plasma and brain tissue levels were measured. It was found that the polymer formulations provided significantly higher plasma levels and significantly lower brain tissue levels of drug than a control, in the form of a simple drug solution. Changing the depth of insertion of the cannula from 7 to 15mm, in order to reach the olfactory region in the nasal cavity significantly decreased plasma levels and significantly increased brain tissue levels of drug for the two formulations studied (1.0% pectin LM-12 and a simple drug solution). There was no significant difference between the drug availability for the bioadhesive formulation and the control in the brain when the longer cannula was used for administration. It is suggested that the conventional rat model is not suitable for evaluation of the effects of bioadhesive formulations in nose-to-brain delivery.

  2. Teacher Union Official and Central Office Administrator Descriptions of the Level of Difficulty and Importance for Negotiating Selected Elements of Annual Professional Performance Review (APPR) into Teacher Collective Bargaining Agreements

    ERIC Educational Resources Information Center

    Neville, Patricia A.

    2012-01-01

    The relationship between teacher union officials and central office administrators' descriptions of the level of importance and the level of difficulty when negotiating Annual Professional Performance Review (APPR) language into a teachers' union collective bargaining agreement was examined. Relationships were investigated using the New York State…

  3. Higher Education Administrators' Perceptions of the Academic Quality Improvement Project as Compared to the Program to Evaluate and Advance Quality within the North Central Association of Colleges and Schools

    ERIC Educational Resources Information Center

    McDonough, Jennifer Nobles

    2012-01-01

    The purpose of this study was to examine higher education administrators' perceptions of the effectiveness of the Academic Quality Improvement Project (AQIP) as compared to the Program to Evaluate and Advance Quality (PEAQ) within the North Central Association of Colleges and Schools (NCA). The Higher Learning Commission (HLC), a commission of the…

  4. Influence of intramuscular heat stimulation on modulation of nociception: complex role of central opioid receptors in descending facilitation and inhibition.

    PubMed

    You, Hao-Jun; Lei, Jing; Ye, Gang; Fan, Xiao-Li; Li, Qiang

    2014-10-01

    It has been reported that the threshold to activate 'silent' or inactive descending facilitation of nociception is lower than that of descending inhibition. Thus, the development of pain therapy to effectively drive descending inhibition alone, without the confounding influences of facilitation is a challenge. To address this issue we investigated the effects of intramuscular stimulation with a heating-needle on spinal nociception, assessed by measuring nociceptive paw withdrawal reflex in rats. Additionally, involvement of the thalamic 'nociceptive discriminators' (thalamic mediodorsal (MD) and ventromedial (VM) nuclei), and opioid-mediated mechanisms were further explored. Descending facilitation and inhibition were elicited by 46°C noxious heating-needle stimulation, and were regulated by thalamic MD and VM nuclei, respectively. In contrast, innocuous heating-needle stimulation at a temperature of 43°C elicited descending inhibition modulated by the thalamic VM nucleus alone. Microinjection of μ/δ/κ-opioid receptor antagonists β-funaltrexamine hydrochloride/naltrindole/nor-binaltorphimine, into the VM nucleus attenuated the 46°C intramuscular heating-needle stimulation-evoked descending inhibition, whereas treatment of the MD nucleus with β-funaltrexamine hydrochloride significantly decreased the descending facilitation. By contrast, descending inhibition evoked by 43°C heating-needle stimulation was only depressed by naltrindole, as opposed to μ- and κ-opioid receptor antagonists, which failed to influence descending inhibition. The present study reveals distinct roles of μ-opioid receptors in the function of thalamic MD and VM nuclei,which exert facilitatory and inhibitory actions on nociception. Furthermore, innocuous, but not noxious, intramuscular heating-needle stimulation targeting δ-opioid receptors is suggested to be a promising avenue for the effective inhibition of pain.

  5. Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.

    PubMed

    Yang, Yan; Yang, Fei; Yang, Fan; Li, Chun-Li; Wang, Yan; Li, Zhen; Lu, Yun-Fei; Yu, Yao-Qing; Fu, Han; He, Ting; Sun, Wei; Wang, Rui-Rui; Chen, Jun

    2016-02-01

    The α2δ-1 subunit of the voltage-gated Ca(2+) channel (VGCC) is a molecular target of gabapentin (GBP), which has been used as a first-line drug for the relief of neuropathic pain. GBP exerts its anti-nociceptive effects by disrupting trafficking of the α2δ-1 subunit to the presynaptic membrane, resulting in decreased neurotransmitter release. We previously showed that GBP has an anti-allodynic effect in the first two weeks; but this is followed by insensitivity in the later stage after repeated administration in a rat model of central post-stroke pain (CPSP) hypersensitivity induced by intra-thalamic hemorrhage. To explore the mechanisms underlying GBP insensitivity, the cellular localization and time-course of expression of the α2δ-1 subunit in both the thalamus and spinal dorsal horn were studied in the same model. We found that the α2δ-1 subunit was mostly localized in neurons, but not astrocytes and microglia. The level of α2δ-1 protein increased in the first two weeks after injury but then decreased in the third week, when GBP insensitivity occurred. Furthermore, the α2δ-1 down-regulation was likely caused by later neuronal loss in the injured thalamus through a mechanism other than apoptosis. In summary, the present results suggest that the GBP receptor α2δ-1 is mainly expressed in thalamic neurons in which it is up-regulated in the early stage of CPSP but this is followed by dramatic down-regulation, which is likely associated with GBP insensitivity after long-term use.

  6. Oral Administration of Heat-Inactivated Lactobacillus plantarum K37 Modulated Airway Hyperresponsiveness in Ovalbumin-Sensitized BALB/c Mice

    PubMed Central

    Liu, Yen-Wenn; Liao, Tan-Wei; Chen, Yu-Han; Chiang, Yi-Chin; Tsai, Ying-Chieh

    2014-01-01

    This study aimed to investigate the anti-allergic effects of Lactobacillus plantarum K37 (K37) on airway hyperresponsiveness (AHR) and systemic allergic responses in ovalbumin (OVA)-sensitized and -challenged BALB/c mice. Heat-inactivated K37 (105, 107, and 109 CFU/mouse, day) were orally administered to OVA-sensitized BALB/c mice to investigate their effects on AHR, immunoglobulin (Ig) and cytokine production. The results showed that K37 dose-dependently lowered the serum levels of IgE, OVA-specific IgE and OVA-specific IgG1, ameliorated AHR induced by methacholine and suppressed eosinophil infiltration in bronchoalveolar lavage fluid (BALF). The cytokine production in spleen cells culture and BALF showed that K37 drove the immune responses toward T-helper cell type 1 (Th1) responses, elevated levels of IL-2 and IFN-γ, and reduced of IL-4, IL-5 and IL-13. K37 also improved cell infiltration in lung sections. Our results demonstrated that oral administration of K37 alleviated effectively the allergic responses in vivo. Thus, K37 can be a good source material and a promising candidate for prophylactic and therapeutic treatments of allergic diseases, like asthma. PMID:24936861

  7. Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice.

    PubMed

    Maeda, Naoyoshi; Nakamura, Risa; Hirose, Yoshitaka; Murosaki, Shinji; Yamamoto, Yoshihiro; Kase, Tetsuo; Yoshikai, Yasunobu

    2009-08-01

    We have previously reported that heat-killed Lactobacillus plantarum L-137 (HK-LP) stimulates macrophage/dendritic cells to produce T helper (Th) 1-related cytokines in vitro and in vivo in mice. We here examined the effect of oral administration of HK-LP on protection against influenza virus infection in mice. C57BL/6 mice were orally given HK-LP from day -7 to 7 and intranasally infected with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) at 100 pfu on day 0. The survival time was significantly prolonged in mice treated with HK-LP than that in mice treated with PBS as controls. The viral titers in the lung were significantly lower in mice treated with HK-LP than controls at the early stage after influenza virus infection. An appreciable level of interferon (IFN)-beta was detected in the serum of mice treated with HK-LP, while no IFN-beta was detected in controls after influenza infection. Our results suggest that HK-LP, a potent IFN-beta inducer, is useful for prevention against influenza infection.

  8. Design, cost and performance comparisons of several solar thermal systems for process heat. Volume 4: Energy centralization

    NASA Astrophysics Data System (ADS)

    Iannucci, J. J.; Hostetler, L. D.

    1981-03-01

    A large matrix of self-consistent piping systems for dishes, troughs, and central receivers are designed, costed, and analyzed for performance. The solar installations collect thermal energy at temperatures ranging from 2000 to 20000 F, at sizes of 3, 30, 300, and 1500 megawatts thermal. First order design differences and similaies are highlighted, with emphasis on the comparison of dish and trough piping. Dishes are found to inefficient piping networks due to the large length of piping required.

  9. Natural heat storage in a brine-filled solar pond in the Tully Valley of central New York

    USGS Publications Warehouse

    Hayhurst, Brett; Kappel, William M.

    2014-01-01

    The Tully Valley, located in southern Onondaga County, New York, has a long history of unusual natural hydrogeologic phenomena including mudboils (Kappel, 2009), landslides (Tamulonis and others, 2009; Pair and others, 2000), landsurface subsidence (Hackett and others, 2009; Kappel, 2009), and a brine-filled sinkhole or “Solar pond” (fig. 1), which is documented in this report. A solar pond is a pool of salty water (brine) which stores the sun’s energy in the form of heat. The saltwater naturally forms distinct layers with increasing density between transitional zones (haloclines) of rapidly changing specific conductance with depth. In a typical solar pond, the top layer has a low salt content and is often times referred to as the upper convective zone (Lu and others, 2002). The bottom layer is a concentrated brine that is either convective or temperature stratified dependent on the surrounding environment. Solar insolation is absorbed and stored in the lower, denser brine while the overlying halocline acts as an insulating layer and prevents heat from moving upwards from the lower zone (Lu and others, 2002). In the case of the Tully Valley solar pond, water within the pond can be over 90 degrees Fahrenheit (°F) in late summer and early fall. The purpose of this report is to summarize observations at the Tully Valley brine-filled sinkhole and provide supplemental climate data which might affect the pond salinity gradients insolation (solar energy).

  10. Is the oceanic heat flux on the central Amundsen sea shelf caused by barotropic or baroclinic currents?

    NASA Astrophysics Data System (ADS)

    Kalén, Ola; Assmann, Karen M.; Wåhlin, Anna K.; Ha, Ho Kyung; Kim, Tae Wan; Lee, Sang Hoon

    2016-01-01

    The glaciers that drain the West Antarctic Ice Sheet into the Amundsen Sea are accelerating and experiencing increased basal melt of the floating ice shelves. Warm and salty deep water has been observed to flow southward in deep troughs leading from the shelf break to the inner shelf area where the glaciers terminate. It has been suggested that the melting induced by this warm water is responsible for the acceleration of the glaciers. Here we investigate the structure of the currents and the associated heat flow on the shelf using in-situ observations from 2008 to 2014 in Dotson Trough, the main channel in the western part of the Amundsen Sea shelf, together with output from a numerical model. The model is generally able to reproduce the observed velocities and temperatures in the trough, albeit with a thicker warm bottom layer. In the absence of measurements of sea surface height we define the barotropic component of the flow as the vertical average of the velocity. It is shown that the flow is dominated by warm barotropic inflows on the eastern side and colder and fresher barotropic outflows on the western side. The transport of heat appears to be primarily induced by this clockwise barotropic circulation in the trough, contrary to earlier studies emphasizing a bottom-intensified baroclinic inflow as the main contributor.

  11. The Perspectives of University Administrators towards International Leadership, Study Abroad Programs, and Cooperative Agreements in Central American Public and Private Universities

    ERIC Educational Resources Information Center

    Curbelo Ruiz, Aurelio

    2013-01-01

    As the world becomes globalized by the influence of science and technology, academic institutions in Central America must provide international academic and research opportunities that are conductive to multicultural learning for students, faculty, and staff. Public and private universities in Central America are attempting to increase awareness…

  12. Immune responses and stress resistance in red sea bream, Pagrus major, after oral administration of heat-killed Lactobacillus plantarum and vitamin C.

    PubMed

    Dawood, Mahmoud A O; Koshio, Shunsuke; Ishikawa, Manabu; Yokoyama, Saichiro

    2016-07-01

    The present study evaluated the interactive benefits of dietary administration of heat-killed Lactobacillus plantarum (LP) and vitamin C (VC) on the growth, oxidative status and immune response of red sea bream (Pagrus major). A diet without LP and VC supplements was employed as a control diet. Four other test diets with 0 or 1 g LP kg(-1) combined with 0.5 or 1 g VC kg(-1) (2 × 2 factorial design) were fed to red sea bream (2 ± 0.01 g) for 56 days. A significant interaction was found between LP and VC on final body weight (FNW), weight gain (WG), hematocrit (HCT), serum bactericidal (BA) and lysozyme (LZY) activities, mucus LZY and peroxidase (PA) activities, nitro blue tetrazolium (NBT), catalase, mucus secretion and tolerance against low salinity stress test (LT50) (P < 0.05). In addition, FNW, WG, specific growth rate, feed and protein efficiency ratio, serum (BA, LZY, PA and NBT), mucus (LZY and PA), superoxide dismutase, malondialdehyde and mucus secretion were significantly affected by either LP or VC (P < 0.05). Furthermore, only LP was a significant factor on survival, plasma total cholesterol, mucus BA and alternative complement pathway (P < 0.05). However, VC supplementation affected on HCT and LT50. Interestingly, fish fed with both LP at 1 g kg(-1) diet with VC at 0.5 or 1 g kg(-1) diet showed higher growth, humoral and mucosal immune responses, anti-oxidative status, mucus secretion and LT50 as well as decreased plasma, triglyceride and total cholesterol levels than the fish fed control diet (P < 0.05). These results demonstrated that dietary LP and VC had a significant interaction for red sea bream with the capability of improving growth performance and enhancing stress resistance by immunomodulation.

  13. Demonstration of the use of ADAPT to derive predictive maintenance algorithms for the KSC central heat plant

    NASA Technical Reports Server (NTRS)

    Hunter, H. E.

    1972-01-01

    The Avco Data Analysis and Prediction Techniques (ADAPT) were employed to determine laws capable of detecting failures in a heat plant up to three days in advance of the occurrence of the failure. The projected performance of algorithms yielded a detection probability of 90% with false alarm rates of the order of 1 per year for a sample rate of 1 per day with each detection, followed by 3 hourly samplings. This performance was verified on 173 independent test cases. The program also demonstrated diagnostic algorithms and the ability to predict the time of failure to approximately plus or minus 8 hours up to three days in advance of the failure. The ADAPT programs produce simple algorithms which have a unique possibility of a relatively low cost updating procedure. The algorithms were implemented on general purpose computers at Kennedy Space Flight Center and tested against current data.

  14. Warm Molecular Gas Traced with CO J = 7 --> 6 in the Galaxy's Central 2 Parsecs: Dynamical Heating of the Circumnuclear Disks

    NASA Technical Reports Server (NTRS)

    Bradford, C. M.; Stacey, G. J.; Nikola, T.; Bolatto, A. D.; Jackson, J. M.; Savage, M. L.; Davidson, J. A.

    2005-01-01

    We present an 11" resolution map of the central 2 pc of the Galaxy in the CO J = 7 --> 6 rotational transition. The CO emission shows rotation about Sgr A* but also evidence for noncircular turbulent motion and a clumpy morphology. We combine our data set with available CO measurements to model the physical conditions in the disk. We find that the molecular gas in the region is both warm and dense, with T approx. 200-300 K and n(sub H2) approx. (5-7) x 10(exp 4) cm(exp -3). The mass of warm molecular gas we measure in the central 2 pc is at least 2000 M(solar), about 20 times the UV-excited atomic gas mass, ruling out a UV heating scenario for the molecular material. We compare the available spectral tracers with theoretical models and conclude that molecular gas is heated with magnetohydrodynamic shocks with v approx. 10-20 km s(exp -1) and B approx. 0.3- 0.5 mG. Using the conditions derived with the CO analysis, we include the other important coolants, neutral oxygen and molecular hydrogen, to estimate the total cooling budget of the molecular material. We derive a mass-to-luminosity ratio of approx. 2-3 M(solar)(L(solar)exp -1), which is consistent with the total power dissipated via turbulent decay in 0.1 pc cells with v(sub rms) approx. 15 kilometers per second. These size and velocity scales are comparable to the observed clumping scale and the velocity dispersion. At this rate, the material near Sgr A* is dissipating its orbital energy on an orbital timescale and cannot last for more than a few orbits. Our conclusions support a scenario in which the features near Sgr A* such as the circumnuclear disk and northern arm are generated by infalling clouds with low specific angular momentum.

  15. Energy Corner: Heat Reclamation Rescues Wasted Heat.

    ERIC Educational Resources Information Center

    Daugherty, Thomas

    1982-01-01

    Heat reclamation systems added to pre-existing central heating systems provide maximum savings at minimum cost. The benefits of a particular appliance marketed under the brand name "Energizer" are discussed. (Author/MLF)

  16. Administrators: Nursing Home Administrator

    ERIC Educational Resources Information Center

    Kahl, Anne

    1976-01-01

    Responsibilities, skills needed, training needed, earnings, employment outlook, and sources of additional information are outlined for the administrator who holds the top management job in a nursing home. (JT)

  17. Rewetting of Vertical Hot Surface in a Centrally Heated Annulus and a 6 x 6 Rod Bundle Geometry During Reflood Phase

    SciTech Connect

    Seok Cho; Sang-Ki Moon; Ki-Yong Choi; Se-Young Chun; Moon-Ki Chung; Won-Pil Baek

    2006-07-01

    A series of bottom reflood tests were carried out to investigate thermal-hydraulic characteristics during the reflood phase. This paper includes descriptions of three related groups of reflood tests categorized by the geometry of a flow channel and an electric power shape of heater rods. A centrally-heated annular geometry with an outer-visualizing tube was adopted for the first two groups of tests (group-A and -B), and a 6 x 6 rod bundle geometry for the other group of tests (group-C). The ranges of experimental parameters are 2{approx}8 cm/s of flooding velocity, 20{approx}80 deg. C of inlet subcooling temperature, and 500{approx}700 deg. C of initial wall temperature. In the single rod annular flow channel reflood test, quench front behavior can be easily observed through the visualizing window and a dominant flow regime near downstream of quench front is inverted annular film boiling regardless of the flooding velocity. For the case of the 6 x 6 rod bundle experiments, on the other hand, the dominant flow regime is dispersed flow film boiling (DFFB), and therefore the thermal hydraulic behavior becomes more complicated and chaotic due to the interaction between liquid phase such as droplet and liquid film and vapor phase generated from liquid-wall heat transfer. (authors)

  18. Plasma production and heating in a tandem mirror central cell by radio-frequency waves in the ion cyclotron frequency range

    NASA Astrophysics Data System (ADS)

    Golovato, S. N.; Brau, K.; Casey, J.; Coleman, J.; Gerver, M. J.; Guss, W.; Hallock, G.; Horne, S.; Irby, J.; Kumazawa, R.; Kesner, J.; Lane, B.; Machuzak, J.; Moran, T.; Myer, R.; Post, R. S.; Sevillano, E.; Smith, D. K.; Sullivan, J. D.; Torti, R.; Wang, L.; Yasaka, Y.; Yao, X. Z.; Zielinski, J.

    1988-12-01

    Plasma production and heating in the central cell of the Tara tandem mirror [Nucl. Fusion 22, 549 (1982); Plasma Physics and Controlled Nuclear Fusion Research, 1986, Proceedings of the 11th International Conference, Kyoto, Japan (IAEA, Vienna, 1987), Vol. 2, p. 251] have been studied. Using radio-frequency excitation by a slot antenna in the ion cyclotron frequency range (ICRF), plasmas with a peak β⊥ of 3%, density of 4×1012 cm-3, ion temperature of 800 eV, and electron temperature of 75-100 eV were routinely produced. The plasma radius decreased with increasing ICRF power, causing reduced ICRF coupling and saturation of the plasma beta. About 70% of the applied ICRF power can be accounted for in direct heating of both ions and electrons. Wave field measurements have identified the applied ICRF to be the slow, ion cyclotron wave. In operation without end plugging, the plasma parameters were limited by poor axial confinement and the requirements for maintenance of magnetohydrodynamic stability and microstability.

  19. Clay mineralogy and thermal history of the Neogene Vinchina Basin, central Andes of Argentina: Analysis of factors controlling the heating conditions

    NASA Astrophysics Data System (ADS)

    Collo, Gilda; DáVila, Federico M.; Nóbile, Julieta; Astini, Ricardo A.; Gehrels, George

    2011-08-01

    The Vinchina Foreland Basin, western Argentina, contains a ˜7 km thick nonmarine stratigraphy, chronologically constrained within the Mio-Pliocene (circa 19-3.4 Ma), and where distribution of Illite/Smectite interstratified phases has shown a progressive smectite-illitization progress (R0 → R1 → R3), is consistent with an incipient burial history. R0 represents randomly mixed-layered illite/smectite normally found at shallow depths, as this ordering is not stable at ˜120°C. In the Vinchina Basin, however, the R0 is still persistent at ˜7 km depth, and its appearance even in the deepest levels is consistent with previous interpretations of low burial temperatures based on thermochronologic studies of detrital apatites. The maximum paleotemperature estimation and basin depth imply geothermal gradient as low as ˜15°C/km, which allowed an estimate of heat flow values between 33 and 42 mW/m2, that would rise to between ˜40 and 51 mW/m2 when the sedimentation rate (thermal blanketing) is taken into account. These values were only reported for cold basins and represent a paleothermal state of a refrigerated lithosphere. We suggest the central Andes were dominated since the Miocene by heat transfer derived mostly from crustal contributions with a minimum input from the asthenosphere. This refrigerated lithosphere is typical of segments affected by flat subduction. Preliminary thermal models based on previous geodynamic approaches support our conclusions.

  20. Quantitative Analysis of the Principal-Agent Problem in Commercial Buildings in the U.S.: Focus on Central Space Heating and Cooling

    SciTech Connect

    Blum, Helcio; Sathaye, Jayant

    2010-05-14

    We investigate the existence of the principal-agent (PA) problem in non-government, non-mall commercial buildings in the U.S. in 2003. The analysis concentrates on space heating and cooling energy consumed by centrally installed equipment in order to verify whether a market failure caused by the PA problem might have prevented the installation of energy-efficient devices in non-owner-occupied buildings (efficiency problem) and/or the efficient operation of space-conditioning equipment in these buildings (usage problem). Commercial Buildings Energy Consumption Survey (CBECS) 2003 data for single-owner, single-tenant and multi-tenant occupied buildings were used for conducting this evaluation. These are the building subsets with the appropriate conditions for assessing both the efficiency and the usage problems. Together, these three building types represent 51.9percent of the total floor space of all buildings with space heating and 59.4percent of the total end-use energy consumption of such buildings; similarly, for space cooling, they represent 52.7percent of floor space and 51.6percent of energy consumption. Our statistical analysis shows that there is a usage PA problem. In space heating it applies only to buildings with a small floor area (<_50,000 sq. ft.). We estimate that in 2003 it accounts for additional site energy consumption of 12.3 (+ 10.5 ) TBtu (primary energy consumption of 14.6 [+- 12.4] TBtu), corresponding to 24.0percent (+- 20.5percent) of space heating and 10.2percent (+- 8.7percent) of total site energy consumed in those buildings. In space cooling, however, the analysis shows that the PA market failure affects the complete set of studied buildings. We estimate that it accounts for a higher site energy consumption of 8.3 (+-4.0) TBtu (primary energy consumption of 25.5 [+- 12.2]TBtu), which corresponds to 26.5percent (+- 12.7percent) of space cooling and 2.7percent (+- 1.3percent) of total site energy consumed in those buildings.

  1. Power and Efficiency Analysis of a Solar Central Receiver Combined Cycle Plant with a Small Particle Heat Exchanger Receiver

    NASA Astrophysics Data System (ADS)

    Virgen, Matthew Miguel

    Two significant goals in solar plant operation are lower cost and higher efficiencies. To achieve those goals, a combined cycle gas turbine (CCGT) system, which uses the hot gas turbine exhaust to produce superheated steam for a bottoming Rankine cycle by way of a heat recovery steam generator (HRSG), is investigated in this work. Building off of a previous gas turbine model created at the Combustion and Solar Energy Laboratory at SDSU, here are added the HRSG and steam turbine model, which had to handle significant change in the mass flow and temperature of air exiting the gas turbine due to varying solar input. A wide range of cases were run to explore options for maximizing both power and efficiency from the proposed CSP CCGT plant. Variable guide vanes (VGVs) were found in the earlier model to be an effective tool in providing operational flexibility to address the variable nature of solar input. Combined cycle efficiencies in the range of 50% were found to result from this plant configuration. However, a combustor inlet temperature (CIT) limit leads to two distinct Modes of operation, with a sharp drop in both plant efficiency and power occurring when the air flow through the receiver exceeded the CIT limit. This drawback can be partially addressed through strategic use of the VGVs. Since system response is fully established for the relevant range of solar input and variable guide vane angles, the System Advisor Model (SAM) from NREL can be used to find what the actual expected solar input would be over the course of the day, and plan accordingly. While the SAM software is not yet equipped to model a Brayton cycle cavity receiver, appropriate approximations were made in order to produce a suitable heliostat field to fit this system. Since the SPHER uses carbon nano-particles as the solar absorbers, questions of particle longevity and how the particles might affect the flame behavior in the combustor were addressed using the chemical kinetics software Chemkin

  2. Solar Heating Equipment

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Solar Unlimited, Inc.'s suncatcher line includes a variety of solar arrays, derived from NASA's satellite program: water heating only, partial home heating, or water and whole house central heating. Solar Unlimited developed a set of vigorous requirements to avoid problems common to solar heating technologies.

  3. Oral administration of a curcumin-phospholipid delivery system for the treatment of central serous chorioretinopathy: a 12-month follow-up study

    PubMed Central

    Mazzolani, Fabio; Togni, Stefano

    2013-01-01

    Background The therapeutic effects of Meriva®, a curcumin-phospholipid (lecithin) delivery system (formulated as Norflo® tablets), on visual acuity and retinal thickness in patients with acute and chronic central serous chorioretinopathy was previously investigated in a six-month open-label study. Methods In this follow-up study, visual acuity was again assessed by ophthalmologic evaluation and retinal thickness by optical coherence tomography (OCT). Norflo tablets were administered twice daily to patients with central serous chorioretinopathy. The study group consisted of 12 patients (total 18 eyes) who completed 12 months of follow-up. The primary endpoint was change in visual acuity before and after treatment with Norflo, and change in neuroretinal or retinal pigment epithelium detachment on OCT was the secondary endpoint. Results After 12 months of therapy, no eyes showed further reduction in visual acuity, 39% showed stabilization, and 61% showed statistically significant improvement (P = 0.0001 by Student’s t-test and P = 0.0005 by Wilcoxon signed rank test). Ninety-five percent of eyes showed a reduction in neuroretinal or retinal pigment epithelium detachment and 5% showed stabilization. The difference in retinal thickness after 12 months was statistically significant (P = 0.0001 by Student’s t-test and P = 0.0004 by Wilcoxon signed rank test). Conclusion These results, albeit preliminary, confirm our previous finding that this curcumin delivery system is effective in the management of central serous chorioretinopathy. When administered in a bioavailable formulation, curcumin is worth considering as a therapeutic agent for the management of inflammatory and degenerative eye conditions involving activation of retinal microglial cells. PMID:23723686

  4. Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide.

    PubMed

    Konsman, J P; Veeneman, J; Combe, C; Poole, S; Luheshi, G N; Dantzer, R

    2008-12-01

    Although receptors for the pro-inflammatory cytokine interleukin-1 have long been known to be expressed in the brain, their role in fever and behavioural depression observed during the acute phase response (APR) to tissue infection remains unclear. This may in part be due to the fact that interleukin-1 in the brain is bioactive only several hours after peripheral administration of bacterial lipopolysaccharide (LPS). To study the role of cerebral interleukin-1 action in temperature and behavioural changes, and activation of brain structures during the APR, interleukin-1 receptor antagonist (IL-1ra; 100 microg) was infused into the lateral brain ventricle 4 h after intraperitoneal (i.p.) LPS injection (250 microg/kg) in rats. I.p. LPS administration induced interleukin-1beta (IL-1beta) production in systemic circulation as well as in brain circumventricular organs and the choroid plexus. Intracerebroventricular (i.c.v.) infusion of IL-1ra 4 h after i.p. LPS injection attenuated the reduction in social interaction, a cardinal sign of behavioural depression during sickness, and c-Fos expression in the amygdala and bed nucleus of the stria terminalis. However, LPS-induced fever, rises in plasma corticosterone, body weight loss and c-Fos expression in the hypothalamus and caudal brainstem were not altered by i.c.v. infusion of IL-1ra. These findings, together with our previous observations showing that i.c.v. infused IL-1ra diffuses throughout perivascular spaces, where macrophages express interleukin-1 receptors, can be interpreted to suggest that circulating or locally produced brain IL-1beta acts on these cells to bring about behavioural depression and activation of limbic structures during the APR after peripheral LPS administration.

  5. Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens.

    PubMed

    McConn, Betty R; Yi, Jiaqing; Gilbert, Elizabeth R; Siegel, Paul B; Chowdhury, Vishwajit S; Furuse, Mitsuhiro; Cline, Mark A

    2016-06-01

    Gonadotropin-inhibitory hormone (GnIH), first isolated from the brain of the Japanese quail (Coturnix japonica), when centrally administered exerts orexigenic effects in birds. However, the precise mechanisms mediating this effect are poorly understood and limited information is available on this effect in models of body weight dysfunction. Thus, the purpose of the present study was to investigate appetite-associated effects of GnIH in chicks from lines that have been selected for either low or high body weight, and are anorexic or become obese, respectively. Central GnIH injection increased food intake in both lines with a similar magnitude of response. There was no effect on water intake. Hypothalamic GnIH mRNA was greater in the low than high weight lines and was greater in the fasted than fed chicks. GnIH receptor mRNA was similarly expressed in both lines, and was greater in fed than fasted chicks. Thus, although selection for body weight did not alter the effect of GnIH on feeding, fasting increased GnIH mRNA in both lines implying that it is an innate hunger factor.

  6. Enhanced central serotonin release from slices of rat hypothalamus following repeated nialamide administration: evidence supporting the overactive serotonin receptor theory of depression

    SciTech Connect

    Offord, S.J.

    1986-01-01

    Researchers are suggesting unipolar affective disorders may be related to an abnormality in biogenic amine receptor-sensitivity. This abnormality may be a result of a dysfunction in central serotonin (5-HT) release mechanisms. 5-HT neurotransmission is modulated by presynaptic autoreceptors, which are members of the 5-HT/sub 1/ receptor subtype. The autoreceptor is thought to play an important role in the homeostasis of the central 5-HT synapse and could be a site at which some antidepressants mediate their therapeutic effect. The number of 5-HT/sub 1/ type receptor binding sites are reduced and behavior mediated by this receptor is abolished following repeated injections of monoamine oxidase inhibitor type antidepressants. These changes did not occur following a single injection. It was hypothesized that repeated treatment with a monoamine oxidase inhibitor would reduce the sensitivity of 5-HT autoreceptors and enhance 5-HT release. Rats were pretreated with single or repeated (twice daily for 7 days) intraperitoneal injections of nialamide (40 mg/kg) or chlorimipramine (10 mg/kg) and the ability of the autoreceptor agonist to inhibit potassium-induced /sup 3/H-5-HT release was evaluated using an in vitro superfusion system. These changes in 5-HT autoreceptor activity are consistent with other reports evaluating monoamine oxidase inhibitors on 5-HT/sub 1/ type receptors. It is hypothesized that the changes in 5-HT neurotransmission are related to the antidepressant mechanism of monoamine oxidase inhibitors.

  7. Effects of tumor necrosis factor-alpha central administration on hippocampal damage in rat induced by amyloid beta-peptide (25-35).

    PubMed

    Stepanichev, Mikhail Yu; Zdobnova, Irina M; Yakovlev, Alexander A; Onufriev, Mikhail V; Lazareva, Natalia A; Zarubenko, Irina I; Gulyaeva, Natalia V

    2003-01-01

    Male Wistar rats received unilateral intrahippocampal injections of 3 nmol (3.18 microg) aggregated Abeta(25-35), intracerebroventricular bilateral injections of 0.5 microg human recombinant TNFalpha or both (Abeta(25-35) + TNFalpha-treated animals). Seven days after the surgery brain sections were stained with cresyl violet (Nissl), for fragmented DNA (TUNEL), glial fibrillar acidic protein (GFAP) and isolectin B4-reactive microglia. In addition, caspase-3 activity in brain regions was measured fluorometrically. The morphology of the hippocampus after the injection of Abeta(25-35) or both Abeta(25-35) and TNFalpha (but not TNFalpha alone) showed cell loss in the CA1 pyramidal cell layer. The extension of neuronal degeneration measured in the CA1 field was significantly larger in Abeta(25-35)-treated groups compared to the contralateral hemisphere of both vehicle-treated controls and animals injected with TNFalpha alone. TNFalpha augmented the Abeta(25-35)-induced damage, significantly increasing the extension of degenerating area. Administration of Abeta(25-35) caused reactive gliosis in the ipsilateral hemisphere as demonstrated by upregulation of GFAP expression and the presence of hypertrophic astrocytes in the hippocampus. This effect was much more prominent in the hippocampi of rats treated with Abeta(25-35) + TNFalpha but absent after administration of TNFalpha alone. In both Abeta(25-35)-treated groups, the damaged area of the hippocampal CA1 field and lateral band of dentate gyrus displayed many darkly stained round isolectin B4-positive phagocyte-like microglial cells. Sparse TUNEL-positive nuclei were found in the hippocampi of rats treated with Abeta(25-35) alone or together with TNFalpha, but not in the control brain sections or in brain sections of TNFalpha-injected animals. The activity of caspase-3 increased significantly in the ipsilateral hippocampus after the injection of Abeta(25-35). Surprisingly, administration of TNFalpha into the cerebral

  8. Pharmacokinetics and tissue distribution of 14C-labeled grape polyphenols in the periphery and the central nervous system following oral administration.

    PubMed

    Janle, Elsa M; Lila, Mary Ann; Grannan, Michael; Wood, Lauren; Higgins, Aine; Yousef, Gad G; Rogers, Randy B; Kim, Helen; Jackson, George S; Ho, Lap; Weaver, Connie M

    2010-08-01

    Grape polyphenols confer potential health benefits, including prevention of neurodegenerative diseases. To determine the absorption and tissue distribution of the complex grape polyphenol mixture, (14)C-labeled polyphenols were biosynthesized by grape cell suspension cultures, during co-incubation with radioisotopically labeled sucrose, and fractionated into polyphenolic subfractions. The pharmacokinetics and distribution of grape polyphenols into blood, brain, and peripheral interstitial fluid were determined by tracking the (14)C label. The blood peak (14)C concentration of the fractions ranged from 15 minutes to 4 hours. Absorption and tissue distribution varied greatly between fractions. Concentrations in interstitial fluid were lower than in blood. The amount of residual label in the brain at 24 hours ranged from 0.1% to 1.7% of the dose, depending on the fraction. (14)C label found in the brain tissue and brain microdialysate indicated that grape polyphenols or their metabolites are able to cross the blood-brain barrier. Using (14)C-labeled plant polyphenols it is possible to track the compounds or their metabolic products into any tissue and determine distribution patterns in spite of low concentrations. A central question regarding the potential role of dietary polyphenolics in neurodegenerative research is whether they are bioavailable in the brain. Our observations indicate that some grape-derived polyphenolics do reach the brain, which suggests their potential value for applications in neurodegenerative disorders.

  9. Effects on the central and peripheral nervous activity in rats elicited by acute administration of lead, mercury and manganese, and their combinations.

    PubMed

    Papp, András; Pecze, László; Szabó, Andrea; Vezér, Tünde

    2006-01-01

    Adult male Wistar rats were treated with inorganic lead, mercury and manganese, and their double combinations, in acute application. The aim was to study the effects on spontaneous and stimulus-evoked cortical, and evoked peripheral, nervous activity, to detect any interaction of the metals and any correlation between the changes caused in the spontaneous and stimulus-evoked electrical activity of the primary somatosensory cortical area, and the compound action potential of the tail nerve. In the frequency distribution of the spontaneous cortical activity, a shift to lower frequencies was seen. The cortical responses evoked by whisker or tail stimulation showed an increase of the peak-to-peak amplitude and peak latency on administration of the metals and metal combinations. With the metal combinations, synergism was observed. Correlations found between alterations of the spontaneous and evoked, or between cortical and peripheral, activity were evaluated in terms of mechanism. According to the results, combined exposure to the three heavy metals studied might lead to synergistic action, indicating an increased health risk in settings with exposure to several heavy metals.

  10. Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats.

    PubMed

    Sato, M; Frohman, L A

    1993-08-01

    The roles of GH and insulin-like growth factor-I (IGF-I) in the regulation of hypothalamic GH-releasing hormone (GRH) and somatostatin (SRIH) gene expression were investigated in the GH-deficient dwarf (dw) rat, in which endogenous feedback signals are lacking. Adult male and female dw rats were treated with GH or IGF-I by systemic (sc) administration or intracerebroventricular (icv) infusion, and hypothalamic GRH and SRIH mRNA were determined by Northern blotting and densitometric analysis. Systemic sc injection of rGH (75 micrograms every 12 h for 3 days) decreased GRH mRNA levels in both sexes. However, systemic sc injection of human IGF-I (150 micrograms every 12 h for 3 days) did not affect GRH mRNA levels in either sex despite significant stimulation of body weight gain. The use of a continuous sc infusion, which normalized serum IGF-I levels, and prolongation of the treatment period to 7 days also failed to change GRH mRNA levels. SRIH mRNA was unaffected by systemic administration of either GH or IGF-I. Continuous icv infusion of GH (1 microgram/h for 7 days) decreased GRH mRNA levels in both sexes, but did not alter SRIH mRNA levels. Continuous icv infusion of IGF-I (100 ng/h for 7 days) decreased GRH mRNA in both sexes. In contrast, SRIH mRNA levels were increased in both sexes. IGF-I decreased GRH mRNA levels at icv infusion rates of 100 and 300 ng/h and stimulated SRIH mRNA levels at infusion rates of 30 and 100 ng/h. Food intake was unaffected at these infusion rates. Changes in GRH and SRIH mRNA levels in response to systemic or central GH and IGF-I administration were similar in both sexes, except that the decrease in GRH mRNA levels produced by the icv infusion of IGF-I was greater in female than in male rats. The results provide evidence for a direct inhibitory feedback effect of GH in the central nervous system on the regulation of hypothalamic GRH gene expression that is independent of peripheral IGF-I. IGF-I feedback, in contrast, appears to

  11. Chronic central administration of apelin-13 over 10 days increases food intake, body weight, locomotor activity and body temperature in C57BL/6 mice.

    PubMed

    Valle, A; Hoggard, N; Adams, A C; Roca, P; Speakman, J R

    2008-01-01

    The peptide apelin has been located in a wide range of tissues, including the gastrointestinal tract, stomach and adipose tissue. Apelin and its receptor has also been detected in the arcuate and paraventricular nuclei of the hypothalamus, which are involved in the control of feeding behaviour and energy expenditure. This distribution suggests apelin may play a role in energy homeostasis, but previous attempts to discern the effects of apelin by acute injection into the brain have yielded conflicting results. We examined the effect of a chronic 10-day intracerebroventricular (i.c.v.) infusion of apelin-13 into the third ventricle on food intake, body temperature and locomotor activity in C57BL/6 mice. Apelin-13 (1 microg/day) increased food intake significantly on days 3-7 of infusion; thereafter, food intake of treated and control individuals converged. This convergence was potentially because of progressive conversion of apelin-13 to [Pyr(1)]apelin-13 which has a four-fold lower receptor binding affinity at the orphan G protein-coupled receptor, APJ. Locomotor activity was also higher in the apelin-treated mice, especially during the nocturnal peak, when most feeding occurs, and the first hours of the light phase. Body temperature was also elevated during this increased period of activity, but was otherwise unaffected. Apelin-13-infused animals gained more weight than the saline-infused controls, suggesting the elevated locomotor activity did not offset the increased food intake. Elevated locomotion and the consequent increases in body temperature were probably secondary effects to the increased food intake. These results suggest that apelin-13 may play a central role in the control of feeding behaviour and is one of only two peripheral ligands known to stimulate rather than inhibit intake. As apelin production is elevated during obesity, this may provide an important feed-forward mechanism exacerbating the problem. Antagonists of the apelin receptor may

  12. Central administration of murine interferon-α induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: a mini-review and original experiments.

    PubMed

    Hayley, Shawn; Scharf, Jeff; Anisman, Hymie

    2013-07-01

    A role for pro-inflammatory cytokines and their neuroinflammatory signaling cascades in depressive pathology has increasingly gained acceptance. In this regard, several lines of evidence suggested that interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) can provoke neurochemical and hormonal changes akin to those associated with psychological stressors, and that these cytokines also induce sickness behaviors that resemble some of the neurovegetative features of depression. Similarly, human depressed patients often display marked changes of pro-inflammatory cytokine levels and immune cell activity. Perhaps more germane in the analysis of the cytokine-depression connection, reports of humans undergoing interferon-α (IFN-α) treatment for certain cancers or viral infections have indicated that the pro-inflammatory cytokine caused signs of major depression in a substantial subset of those treated. In the present investigation, we demonstrated that acute or repeated infusion of IFN-α into the lateral ventricles provoked depressive-like behavior and concomitant changes in serotonin (5-HT) and mRNA expression of particular 5-HT receptors and pro-inflammatory cytokines. These actions were less evident following administration directly into the prefrontal cortex and not apparent at all when administered to the dorsal raphe nucleus. The data are discussed in relation to the induction of depression elicited by IFN-α, and are presented in the context of a mini-review that highlights potential mechanisms through which the cytokine might act to promote psychomotor and affective disturbances and interact with stressors.

  13. Peripheral and central administration of T3 improved the histological changes, memory and the dentate gyrus electrophysiological activity in an animal model of Alzheimer's disease.

    PubMed

    Farbood, Yaghoob; Shabani, Sahreh; Sarkaki, Alireza; Mard, Seyyed Ali; Ahangarpour, Akram; Khorsandi, Layasadat

    2017-01-26

    The amyloid beta (Aβ) induced Alzheimer's disease (AD) is associated with formation the amyloid plaques, cognitive impairments and decline in spontaneous discharge of neurons. In the current study, we evaluated the effect of subcutaneous (S. C) and intrahippocampal (I. H) administrations of triiodothyronine (T3) on the histological changes, memory and the dentate gyrus (DG) electrophysiological activity in an animal model of AD. Eighty adult male Wistar rats (250-300 g) were divided randomly into five groups: Sham-Operated (Sh-O), AD + Vehicle (S. C), AD + Vehicle (I. H), AD+ T3 (S. C) and AD + T3 (I. H). In order to induce animal model of AD, Aβ (10 ng/μl, bilaterally) were injected intrahippocampally. Rats were treated with T3 and/or normal saline for 10 days. Passive avoidance and spatial memory were evaluated in shuttle box apparatus and Morris water maze, respectively. Neuronal single unit recording was assessed from hippocampal DG. The percent of total time that animals spent in target quarter, the mean latency time (sec), the step through latency and the average number of spikes/bin were decreased significantly in AD rats compared with the Sh-O group (p < 0.001) and were increased significantly in AD groups that have received T3 (S. C and I. H) in compared with AD group (p < 0.01, p < 0.001). Also, formation of amyloid plaques was decreased in AD rats treated with T3.The results showed that T3 injection (S. C and I. H), by reduction of neural damage and increment of neuronal spontaneous activity improved the memory deficits in Aβ-induced AD rats.

  14. No Apparent Reduction in Schistosome Burden or Genetic Diversity Following Four Years of School-Based Mass Drug Administration in Mwea, Central Kenya, a Heavy Transmission Area

    PubMed Central

    Lelo, Agola E.; Mburu, David N.; Magoma, Gabriel N.; Mungai, Ben N.; Kihara, Jimmy H.; Mwangi, Ibrahim N.; Maina, Geoffrey M.; Kinuthia, Joseph M.; Mutuku, Martin W.; Loker, Eric S.; Mkoji, Gerald M.; Steinauer, Michelle L.

    2014-01-01

    Background Schistosomiasis is a debilitating neglected tropical disease that infects over 200 million people worldwide. To combat this disease, in 2012, the World Health Organization announced a goal of reducing and eliminating transmission of schistosomes. Current control focuses primarily on mass drug administration (MDA). Therefore, we monitored transmission of Schistosoma mansoni via fecal egg counts and genetic markers in a typical school based MDA setting to ascertain the actual impacts of MDA on the targeted schistosome population. Methods For 4 years, we followed 67 children enrolled in a MDA program in Kenya. Infection status and egg counts were measured each year prior to treatment. For 15 of these children, for which there was no evidence of acquired resistance, meaning they became re-infected following each treatment, we collected microsatellite genotype data from schistosomes passed in fecal samples as a representation of the force of transmission between drug treatments. We genotyped a total of 4938 parasites from these children, with an average of 329.2 parasites per child for the entire study, and an average of 82.3 parasites per child per annual examination. We compared prevalence, egg counts, and genetic measures including allelic richness, gene diversity (expected heterozygosity), adult worm burdens and effective number of breeders among time points to search for evidence for a change in transmission or schistosome populations during the MDA program. Findings We found no evidence of reduced transmission or schistosome population decline over the course of the program. Although prevalence declined in the 67 children as it did in the overall program, reinfection rates were high, and for the 15 children studied in detail, schistosome egg counts and estimated adult worm burdens did not decline between years 1 and 4, and genetic diversity increased over the course of drug treatment. Interpretation School based control programs undoubtedly improve the

  15. Charge exchange recombination spectroscopy measurements in the extreme ultraviolet region of central carbon concentrations during high power neutral beam heating in TFTR (Tokamak Fusion Test Reactor)

    SciTech Connect

    Stratton, B.C.; Fonck, R.J.; Ramsey, A.T.; Synakowski, E.J.; Grek, B.; Hill, K.W.; Johnson, D.W.; Mansfield, D.K.; Park, H.; Taylor, G.; Valanju, P.M. . Plasma Physics Lab.; Texas Univ., Austin, TX . Fusion Research Center)

    1989-09-01

    The carbon concentration in the central region of TFTR discharges with high power neutral beam heating has been measured by charge-extracted recombination spectroscopy (CXRS) of the C{sup +5} n = 3--4 transition in the extreme ultraviolet region. The carbon concentrations were deduced from absolute measurements of the line brightness using a calculation of the beam attenuation and the appropriate cascade-corrected line excitation rates. As a result of the high ion temperatures in most of the discharges, the contribution of beam halo neutrals to the line brightness was significant and therefore had to be included in the modeling of the data. Carbon concentrations have been measured in discharges with I{sub p} = 1.0-1.6 MA and beam power in the range of 2.6-30 MW, including a number of supershots. The results are in good agreement with carbon concentrations deduced from the visible bremsstrahlung Z{sub eff} and metallic impurity concentrations measured by x-ray pulse-height analysis, demonstrating the reliability of the atomic rates used in the beam attenuation and line excitation calculations. Carbon is the dominant impurity species in these discharges; the oxygen concentration measured via CXRS in a high beam power case was 0.0006 of n{sub e}, compard to 0.04 for carbon. Trends with I{sub p} and beam power in the carbon concentration and the inferred deuteron concentration are presented. The carbon concentration is independent of I{sub p} and decreases from 0.13 at 2.6 MW beam power to 0.04 at 30 MW, while the deuteron concentration increases from 0.25 to 0.75 over the same range of beam power. These changes are primarily the result of beam particle fueling, as the carbon density did not vary significantly with beam power. The time evolutions of the carbon and deuteron concentrations during two high power beam pulses, one which exhibited a carbon bloom and one which did not, are compared. 30 refs., 12 figs., 2 tabs.

  16. 10 CFR Appendix M to Subpart B of... - Uniform Test Method for Measuring the Energy Consumption of Central Air Conditioners and Heat Pumps

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... testing with the following installed: (1) the most restrictive filter(s); (2) supplementary heating coils... ducted unit without having an indoor air filter installed is permissible as long as the minimum external... on region IV.) For heat pumps that use a time-adaptive defrost control system (see Definition...

  17. 10 CFR Appendix M to Subpart B of... - Uniform Test Method for Measuring the Energy Consumption of Central Air Conditioners and Heat Pumps

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... testing with the following installed: (1) the most restrictive filter(s); (2) supplementary heating coils... ducted unit without having an indoor air filter installed is permissible as long as the minimum external... on region IV.) For heat pumps that use a time-adaptive defrost control system (see Definition...

  18. 10 CFR Appendix M to Subpart B of... - Uniform Test Method for Measuring the Energy Consumption of Central Air Conditioners and Heat Pumps

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... testing with the following installed: (1) the most restrictive filter(s); (2) supplementary heating coils... ducted unit without having an indoor air filter installed is permissible as long as the minimum external... on region IV.) For heat pumps that use a time-adaptive defrost control system (see Definition...

  19. Administrative Synergy

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  20. Intrapleural administration of vitreous high duty ceramic fibres and heated devitrified ceramic fibres does not give rise to pleural mesothelioma in rats.

    PubMed

    Carthew, P; Edwards, R E; Dorman, B M; Brown, R C; Young, J; Laskowski, J J; Wagner, J C

    1995-08-01

    In order to determine whether they are potentially carcinogenic to the pleural mesothelium, three samples of ceramic fibre have been administered to rats by the intrapleural route. These samples were a high-duty grade refractory ceramic fibre (manufactured by Thermal Ceramics Ltd) in the as-manufactured vitreous state and two devitrified samples produced by heating the same fibre for 2 weeks at 1200 degrees C and for two weeks at 1400 degrees C. The mean lifespans of the groups of rats treated with vitrified and devitrified ceramic fibres were not significantly different from that of the control rats. In these studies none of the treated or control rats developed pleural mesothelioma, making it unlikely that ceramic fibres of this type, whether vitreous or devitrified, are potentially carcinogenic to the pleural mesothelium.

  1. Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat.

    PubMed

    Owens, M J; Ballenger, C A; Knight, D L; Nemeroff, C B

    1996-09-01

    There is considerable evidence that the number of platelet 5-hydroxytryptamine (5-HT) transporter binding sites, as measured by [3H]imipramine binding, are significantly decreased, and platelet 5-HT2 receptor density is increased, in drug-free patients with major depression. To investigate whether these changes in the platelet 5-HT transporter or 5-HT2 receptor sites resulted from known or hypothesized biochemical changes observed in major depression, we examined, in the rat, whether a chronic hyperglucocorticoid state, or decreases or increases in central nervous system 5-HT neurotransmission, altered binding of the selective ligands [3H]citalopram and [125I] (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane to platelet and brain 5-HT transporters and 5-HT2 receptors, respectively. Chronic (6 weeks) hypercorticosteronemia did not alter either brain or platelet 5-HT transporter or 5-HT2A receptor binding. Similarly, 8-week administration of the 5-HT2A/5-HT2C agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, at a dose which down-regulates brain 5-HT2A/2C receptors, did not alter brain or platelet 5-HT transporters or platelet 5-HT2A receptors. Additionally, para-chloroamphetamine-(11 weeks) or fenfluramine-induced chronic (1.5-10 weeks) depletion of central nervous system 5-HT did not alter platelet 5-HT transporter or 5-HT2A receptor binding. Finally, there was no correlation between the number of 5-HT transporters in brain and platelets in any of the control or treatment groups. These findings suggest that the observed changes in platelet 5-HT transporter and 5-HT2A receptor binding in depressed patients are more apt to be of genetic origin (i.e., trait-dependent) rather than an epiphenomenon of hypercortisolemia or altered central nervous system 5-HT status.

  2. Cold Climate Heat Pump

    DTIC Science & Technology

    2013-08-01

    central heating , cooling, and air conditioning (HVAC) system . Both buildings had two zones for heating and cooling, which allowed for a direct...section calls for improved efficiency of mechanical systems as well as an increase of renewable resource usage. Current heating technologies in cold... heated refrigerant is injected into a mixing chamber between the two compressors. The injection leads to a gain in performance of the system through

  3. A Negotiations Primer (Central Administration Survival Kit).

    ERIC Educational Resources Information Center

    Decker, Robert H.

    The role of the school board and strategies for collective bargaining are described in this guide. Section 1 describes the development of a board philosophy, including techniques and imperatives for the collective bargaining table. The second section examines the school board role in negotiations, with a focus on its role in labor relations and…

  4. Extension and improvement of Central Station District heating budget period 1 and 2, Krakow Clean Fossil Fuels and Energy Efficiency Program. Final report

    SciTech Connect

    1997-07-01

    Project aim was to reduce pollution levels in the City of Krakow through the retirement of coal-fired (hand and mechanically-stoked) boiler houses. This was achieved by identifying attractive candidates and connecting them to the Krakow district heating system, thus permitting them to eliminate boiler operations. Because coal is less costly than district hot water, the district heating company Miejskie Przedsiebiorstwo Energetyki Cieplnej S.A., henceforth identified as MPEC, needed to provide potential customers with incentives for purchasing district heat. These incentives consisted of offerings which MPEC made to the prospective client. The offerings presented the economic and environmental benefits to district heating tie-in and also could include conservation studies of the facilities, so that consumption of energy could be reduced and the cost impact on operations mitigated. Because some of the targeted boiler houses were large, the capacity of the district heating network required enhancement at strategic locations. Consequently, project construction work included both enhancement to the district piping network as well as facility tie-ins. The process of securing new customers necessitated the strengthening of MPEC`s competitive position in Krakow`s energy marketplace, which in turn required improvements in marketing, customer service, strategic planning, and project management. Learning how US utilities address these challenges became an integral segment of the project`s scope.

  5. Administrative Ecology

    ERIC Educational Resources Information Center

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  6. Hypothalamic expression of NPY mRNA, vasopressin mRNA and CRF mRNA in response to food restriction and central administration of the orexigenic peptide GHRP-6.

    PubMed

    Johnstone, Louise E; Srisawat, Rungrudee; Kumarnsit, Ekkasit; Leng, Gareth

    2005-03-01

    In this study, we examined the effects of restricted feeding and of central administration of an orexigenic ghrelin agonist GHRP-6 on peptide mRNA expression in the hypothalamus. We compared rats fed ad libitum with rats that were allowed food for only 2?h every day, and treated with a continuous chronic i.c.v. infusion of GHRP-6 or vehicle. Ad libitum fed rats exposed to GHRP-6 increased their food intake and body weight over 6 days, but, at the end of this period, neuropeptide Y mRNA expression in the arcuate nucleus was not different to that in control rats. By contrast, expression of neuropeptide Y mRNA in the arcuate nucleus was elevated in food-restricted rats, consistent with the interpretation that increased expression reflects increased hunger. However, neuropeptide Y mRNA expression was no greater in food-restricted rats infused with GHRP-6 than in food-restricted rats infused with vehicle; thus if the drive to eat was stronger in rats infused with GHRP-6, this was not reflected by higher levels of neuropeptide Y mRNA expression. Expression of vasopressin mRNA and corticotrophin releasing factor (CRF) mRNA in the paraventricular nucleus (PVN) was not changed by food restriction. GHRP-6 infusion increased CRF mRNA expression in ad libitum rats only.

  7. 10 CFR Appendix M to Subpart B of... - Uniform Test Method for Measuring the Energy Consumption of Central Air Conditioners and Heat Pumps

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... for testing. Conduct testing with the following installed: (1) the most restrictive filter(s); (2... restriction. c. Testing a ducted unit without having an indoor air filter installed is permissible as long as... of section 4.2 for information on region IV.) For heat pumps that use a time-adaptive defrost...

  8. Flat device for heat concentration or dispersion

    NASA Technical Reports Server (NTRS)

    Jenkins, R. V.; Sabol, A. P.

    1975-01-01

    Device provides low-cost unit for efficiently transferring heat between, either to or from, flat surface and central point or region. It is based upon vapor heat transfer principle and therefore, extends applicability of heat pipe.

  9. Current irrigation practices in the central United States reduce drought and extreme heat impacts for maize and soybean, but not for wheat

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In this study, we assessed the adaptive effects of irrigation on climatic risks for three crops (maize, soybean, and wheat) at the regional scale from 1981 to 2012 in the Central US. Based on yields of 183 counties for maize, 121 for soybean and 101 for wheat, statistical models were developed for i...

  10. 10-30 micrometer Maps of the Central 5 parsecs of the Galaxy: Heating of the Cavity and Neutral-Gas Disk

    NASA Technical Reports Server (NTRS)

    Telesco, C. M.; Davidson, J. A.; Werner, M. W.

    1995-01-01

    Maps are presented for 10, 20, and 30 micrometers of the central 60' X 90' (RA X Dec) of the galaxy made at approximately 4' resolution with the MSFC bolometer array. The maps are the first to show the thermal emission from dust particles in both the ionized cavity and the neutral-gas ring with high sensitivity and an angular resolution as good as several arcsec.

  11. Feel the heat: The effect of temperature on development, behavior and central pattern generation in 3rd instar Calliphora vicina larvae.

    PubMed

    Hückesfeld, Sebastian; Niederegger, Senta; Schlegel, Philipp; Heinzel, H-G; Spiess, Roland

    2011-01-01

    Like in all poikilothermic animals, higher temperatures increase developmental rate and activity in Calliphora vicina larvae. We therefore could expect temperature to have a persistent effect on the output of the feeding and crawling central pattern generators (CPGs). When confronted with a steep temperature gradient, larvae show evasive behavior after touching the substrate with the cephalic sense organs. Beside this reflex behavior the terminal- and dorsal organ might also mediate long term CPG modulation. Both organs were thermally stimulated while their response was recorded from the maxillary- or antennal nerve. The terminal organ showed a tonic response characteristic while the dorsal organ was not sensitive to temperature. Thermal stimulation of the terminal organ did not affect the ongoing patterns of fictive feeding or crawling, recorded from the antennal- or abdominal nerve respectively. A selective increase of the central nervous system (CNS) temperature accelerated the motor patterns of both feeding and crawling. We propose that temperature affects centrally generated behavior via two pathways: short term changes like thermotaxis are mediated by the terminal organ, while long term adaptations like increased feeding rate are caused by temperature sensitive neurons in the CNS which were recently shown to exist in Drosophila larvae.

  12. Heat pipe array heat exchanger

    DOEpatents

    Reimann, Robert C.

    1987-08-25

    A heat pipe arrangement for exchanging heat between two different temperature fluids. The heat pipe arrangement is in a ounterflow relationship to increase the efficiency of the coupling of the heat from a heat source to a heat sink.

  13. Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration.

    PubMed

    Pepinsky, R Blake; Shao, Zhaohui; Ji, Benxiu; Wang, Qin; Meng, Gym; Walus, Lee; Lee, Xinhua; Hu, Yinghui; Graff, Christilyn; Garber, Ellen; Meier, Werner; Mi, Sha

    2011-11-01

    LINGO-1 (leucine-rich repeat and Ig domain containing NOGO receptor interacting protein-1) is a negative regulator of myelination and repair of damaged axons in the central nervous system (CNS). Blocking LINGO-1 function leads to robust remyelination. The anti-LINGO-1 Li81 antibody is currently being evaluated in clinical trials for multiple sclerosis (MS) and is the first MS therapy that directly targets myelin repair. LINGO-1 is selectively expressed in brain and spinal cord but not in peripheral tissues. Perhaps the greatest concern for Li81 therapy is the limited access of the drug to the CNS. Here, we measured Li81 concentrations in brain, spinal cord, and cerebral spinal fluid in rats after systemic administration and correlated them with dose-efficacy responses in rat lysolecithin and experimental autoimmune encephalomyelitis spinal cord models of remyelination. Remyelination was dose-dependent, and levels of Li81 in spinal cord that promoted myelination correlated well with affinity measurements for the binding of Li81 to LINGO-1. Observed Li81 concentrations in the CNS of 0.1 to 0.4% of blood levels are consistent with values reported for other antibodies. To understand the features of the antibody that affect CNS penetration, we also evaluated the pharmacokinetics of Li81 Fab2, Fab, and poly(ethylene glycol)-modified Fab. The reagents all showed similar CNS exposure despite large differences in their sizes, serum half-lives, and volumes of distribution, and area under the curve (AUC) measurements in the CNS directly correlated with AUC measurements in serum. These studies demonstrate that exposure levels achieved by passive diffusion of the Li81 monoclonal antibody into the CNS are sufficient and lead to robust remyelination.

  14. Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation.

    PubMed Central

    Gijbels, K.; Brocke, S.; Abrams, J. S.; Steinman, L.

    1995-01-01

    BACKGROUND: We previously demonstrated the local production of the pleiotropic cytokine interleukin-6 (IL-6) in the central nervous system (CNS) in experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis. MATERIALS AND METHODS: To assess the role of IL-6 in autoimmune CNS inflammation, we administered neutralizing antibodies to IL-6 in the EAE model. Their effect was examined at the clinical and histopathological level. Levels of administered antibody and IL-6 bioactivity were followed in serum and cerebrospinal fluid (CSF). RESULTS: Systemically administered antibodies penetrated into the fluid CSF in animals in which EAE was induced. Administration of anti-IL-6 reduced the development of actively induced as well as adoptively transferred EAE and was associated with increased levels of IL-6 activity in the CSF and to a lesser extent in the serum. Anti-IL-6 was still effective when given 1 day before the onset of disease signs in adoptively transferred EAE. The disease-reducing effect of anti-IL-6 was also reflected at the pathological level by the absence of inflammatory infiltrates in the CNS. CONCLUSIONS: Our study indicates that IL-6 plays an important role in autoimmune CNS inflammation. However, due to the complex nature of the in vivo interactions of administered antibodies, the disease-reducing effect of the anti-IL-6 antibodies could be caused by neutralization of IL-6 activity or by enhancement of IL-6 activity via induction of higher IL-6 levels in the CNS. Images FIG. 2 FIG. 3 PMID:8612202

  15. Engineering Administration.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    This book is intended to acquaint naval engineering officers with their duties in the engineering department. Standard shipboard organizations are analyzed in connection with personnel assignments, division operations, and watch systems. Detailed descriptions are included for the administration of directives, ship's bills, damage control, training…

  16. Administrative IT

    ERIC Educational Resources Information Center

    Grayson, Katherine, Ed.

    2006-01-01

    When it comes to Administrative IT solutions and processes, best practices range across the spectrum. Enterprise resource planning (ERP), student information systems (SIS), and tech support are prominent and continuing areas of focus. But widespread change can also be accomplished via the implementation of campuswide document imaging and sharing,…

  17. Database Administrator

    ERIC Educational Resources Information Center

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  18. Central electron temperature estimations of TJ-II neutral beam injection heated plasmas based on the soft x ray multi-foil technique

    SciTech Connect

    Baiao, D.; Varandas, C.

    2012-05-15

    The core electron temperature (T{sub e0}) of neutral beam heated plasmas is determined in TJ-II stellarator by using soft x ray detectors with beryllium filters of different thickness, based on the method known as the foil absorption technique. T{sub e0} estimations are done with the impurity code IONEQ, making use of complementary information from the TJ-II soft x ray tomography and the VUV survey diagnostics. When considering the actual electron density and temperature profile shapes, an acceptable agreement is found with Thomson scattering measurements for 8 different magnetic configurations. The impact of the use of both neutral beam injectors on the T{sub e0} measurements is addressed. Also, the behaviour of T{sub e0} during spontaneous profile transitions is presented.

  19. Compliance testing of Eielson AFB (Air Force Base) central heating and power plant, coal-fired Boiler Number 4, Eielson AFB, Arkansas. Final report, 7-15 June 1989

    SciTech Connect

    Garrison, J.A.

    1989-07-01

    At the request of HQ 343 CSG/DEEV and HQ AAC/SGPB, source compliance testing (particulate and visible emissions) of Boiler No 4 in the Eielson AFB Central Heating and Power Plant was conducted on 7-15 June 1989. Testing was performed to determine compliance with regards to the renewal of Alaska Department of Environmental Conservation Air Quality Control Permit to Operate 8331-AA001. Boiler No. 4 was tested on 12 and 14 Jun 89. On 12 June results indicated that visible-emissions standards were met; however, particulate-emissions standards were not met. The boiler was retested on 14 June and all emissions standards were met. All emission requirements for permit renewal have now been met.

  20. Effect of transfer of one or two in vitro-produced embryos and post-transfer administration of gonadotropin releasing hormone on pregnancy rates of heat-stressed dairy cattle.

    PubMed

    Franco, M; Block, J; Jousan, F D; de Castro e Paula, L A; Brad, A M; Franco, J M; Grisel, F; Monson, R L; Rutledge, J J; Hansen, P J

    2006-07-15

    RH or vehicle at Day 11 after anticipated ovulation (i.e. 4 days after embryo transfer). There was no difference in pregnancy rate for cows that received the GnRH or vehicle treatment (18% versus 17%, respectively). In conclusion, neither unilateral transfer of two embryos nor administration of GnRH at Day 11 after anticipated ovulation improved pregnancy rates of dairy cattle exposed to heat stress.

  1. Occupational Stressors and Administrative Role in Educational Organizations.

    ERIC Educational Resources Information Center

    Wiggins, Thomas

    To explore the relationship between occupational stressors and educational administration, a random sample of 226 Oklahoma administrators was given an administrative stress questionnaire. The administrators--including 52 superintendents, 50 central office administrators, 61 secondary principals, and 63 elementary principals--were all enrolled at…

  2. CENTRALIZATION OF CAMPUS CONTROLS.

    ERIC Educational Resources Information Center

    1967

    A COLLEGE CAMPUS HAVING A LARGE NUMBER OF SEPARATE BUILDINGS WITH ONE BASIC HEATING AND COOLING SYSTEM IS AN IDEAL SITUATION FOR REALIZING GREAT BENEFITS FROM CENTRALIZED BUILDING CONTROL SYSTEMS. TYPICAL REQUIREMENTS AND ADVANTAGES OF SUCH SYSTEMS ARE DISCUSSED BRIEFLY AND DESCRIPTIONS OF THE SYSTEM AT FOUR MAJOR UNIVERSITIES ARE GIVEN. THIS…

  3. Chimney heat exchanger

    SciTech Connect

    Whiteley, I.C.

    1981-09-01

    A heat exchanger for installation on the top of a chimney of a building includes a housing having a lower end receiving the top of the chimney and an upper end with openings permitting the escape of effluent from the chimney and a heat exchanger assembly disposed in the housing including a central chamber and a spirally arranged duct network defining an effluent spiral path between the top of the chimney and the central chamber and a fresh air spiral path between an inlet disposed at the lower end of the housing and the central chamber, the effluent and fresh air spiral paths being in heat exchange relationship such that air passing through the fresh air spiral path is heated by hot effluent gases passing upward through the chimney and the effluent spiral path for use in heating the building. A pollution trap can be disposed in the central chamber of the heat exchanger assembly for removing pollutants from the effluent, the pollution trap including a rotating cage carrying pumice stones for absorbing pollutants from the effluent with the surface of the pumice gradually ground off to reveal fresh stone as the cage rotates.

  4. Heat Islands

    EPA Pesticide Factsheets

    EPA's Heat Island Effect Site provides information on heat islands, their impacts, mitigation strategies, related research, a directory of heat island reduction initiatives in U.S. communities, and EPA's Heat Island Reduction Program.

  5. Administrative Utility Analysis: Study Summary.

    ERIC Educational Resources Information Center

    Peat, Marwick, Mitchell and Co., San Juan, Puerto Rico.

    This document summarizes the recommendations made as a result of a study on administrative utility analysis and vocational education programs for Puerto Rico. The major recommendation was that the Area of Vocational and Technical Education (AVTE) in the Puerto Rico Department of Education be restructured at the central organizational level, for…

  6. Administrative Aspects of Educational Planning.

    ERIC Educational Resources Information Center

    Lyons, Raymond, Comp.

    This seminar focused on the need for increased use of educational planning by politicians and administrators in developing and developed countries. The report includes examples of educational planning in centralized governments such as those of France and Rumania as well as in large Federal decentralized governments such as those of Brazil and…

  7. Regulation of Heat Stress by HSF1 and GR

    DTIC Science & Technology

    2015-09-01

    integrity is central to resistance of muscle cells against heat-induced injury. 15. SUBJECT TERMS heat adaptation , heat tolerance, skeletal muscle...Keywords hyperthermia, heat shock, heat injury, heat adaptation , rodent, skeletal muscle, C2C12, myotube, hsp, inflammation, cytokines, oxidative stress

  8. Heat-Related Illnesses

    DTIC Science & Technology

    1988-04-01

    immersion is rapid (see Chapter 3). Convection Heat loss to air and water vapor molecules circulating around the body is termed convection. As ambient...Skin temperature is believed to have an effect on sweating and heat loss , since a person resting in a warm environment with elevated skin temperature...exercise, rapid (10-20 minutes) decreases in central blood volume occur due to several mechanisms, including osmotic loss of plasma water into working

  9. Air Source Cold Climate Heat Pump

    DTIC Science & Technology

    2013-08-01

    The buildings were modified so that one zone used the cold climate heat pump and the other zone used its original modern central HVAC system . Both...been updated with insulation, a sheet metal roof, and a modern central HVAC system . Both buildings had two zones for heating and cooling, which...climate heat pump and the other zone used its original modern central HVAC system . Both zones were instrumented so that energy consumption and

  10. Nasa-wide Standard Administrative Systems

    NASA Technical Reports Server (NTRS)

    Schneck, P.

    1984-01-01

    Factors to be considered in developing agency-wide standard administrative systems for NASA include uniformity of hardware and software; centralization vs. decentralization; risk exposure; and models for software development.

  11. 48 CFR 801.670-4 - National Cemetery Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Authority, and Responsibilities 801.670-4 National Cemetery Administration. The Director of Logistics Management Service, the Centralized Contracting Division, and the Construction Support Division...

  12. Electric heating for high-temperature heat transport fluids

    NASA Astrophysics Data System (ADS)

    Holmes, J. T.

    1985-12-01

    Recent experiences with electric resistance heaters at the solar Central Receiver Test Facility are described. These heaters are used to preheat or maintain equipment used with molten nitrate salt or liquid sodium heat transfer fluids. Results of extensive testing performed to improve the reliability of similar heating systems used in the development program for the sodium-cooled liquid metal fast breeder nuclear reactor are also reviewed. Recommendations are made for increasing the reliability of trace heating systems for high-melting-point heat transfer fluids including thermal design, heating element selection, installation, insulation, and controls.

  13. Distributed Administrative Management Information System (DAMIS).

    ERIC Educational Resources Information Center

    Juckiewicz, Robert; Kroculick, Joseph

    Columbia University's major program to distribute its central administrative data processing to its various schools and departments is described. The Distributed Administrative Management Information System (DAMIS) will link every department and school within the university via micrcomputers, terminals, and/or minicomputers to the central…

  14. The Microcomputer in the Administrative Office.

    ERIC Educational Resources Information Center

    Huntington, Fred

    1983-01-01

    Discusses microcomputer uses for administrative computing in education at site level and central office and recommends that administrators start with a word processing program for time management, an electronic spreadsheet for financial accounting, a database management system for inventories, and self-written programs to alleviate paper…

  15. Heat Pipes

    ERIC Educational Resources Information Center

    Lewis, J.

    1975-01-01

    Describes the construction, function, and applications of heat pipes. Suggests using the heat pipe to teach principles related to heat transfer and gives sources for obtaining instructional kits for this purpose. (GS)

  16. Environmental Assessment of a Central Heating Plant.

    DTIC Science & Technology

    1983-02-01

    Brooks Air Force BaseTexas 78235 ... I 83 06 1 1 !b b ... I II I II I NOTICES When U.S. Government drawings, speoifioations, or other data are used for...this publication is for illustration purposes and does not constitute endorsement or recommendation for use by the United States Air Force. Do not...Environmental UNCLASSIFIED Health Laboratory __ IS&. OECLASSIFICATION/DOWNGRADINGBrooks Air Force Base TX 78235 SCHEDULE IS. DISTRIBUTION STATEMENT (of

  17. Minneapolis district-heating options

    NASA Astrophysics Data System (ADS)

    Stovall, T. K.; Borkowski, R. J.; Karnitz, M. A.; Strom, S.; Linwick, K.

    1981-10-01

    The feasibility of a large-scale district heating system for the Minneapolis central city area was investigated. The analysis was based on a previous city of St. Paul Hot-water district heating study and other studies done by a Swedish engineering firm. Capital costs such as building and heat source conversion, pipeline construction, and equipment were used in comparing the projected expenses of various district heating scenarios. Options such as coal, refuse-derived fuel burning, and cogeneration at the Riverside Power Station were discussed as energy supplies for a cost-effective district heating system.

  18. Heat Rash

    MedlinePlus

    ... clear up the heat rash?Should I use diaper ointment on my child?What caused my heat rash?Should I stop exercising until the heat rash clears up?What is the best way to prevent heat rash? Last Updated: April 2014 This article was contributed by: familydoctor.org editorial staff Tags: ...

  19. Senior Administrators Should Have Administrative Contracts.

    ERIC Educational Resources Information Center

    Posner, Gary J.

    1987-01-01

    Recognizing that termination is viewed by the employee as the equivalent to capital punishment of a career, an administrative contract can reduce the emotional and financial entanglements that often result. Administrative contracts are described. (MLW)

  20. Research Proposal for the Design and Engineering Phase of a Solar Heating and Cooling System Experiment at the Warner Robins Public Library, Warner Robins, Georgia. Submitted to the United States Energy Research and Development Administration.

    ERIC Educational Resources Information Center

    Phillips, Warren H.; And Others

    A number of reasons are advanced to include a solar heating and cooling experiment in a library building. The unique aspects of the experiment are to be a seasonally adjustable collector tilt and testing of a new generation of absorption air conditioners. After a brief description of the proposed experiment, the proposal contains forms filed by…

  1. The General Heating Multi-Project Pack

    ERIC Educational Resources Information Center

    Cowking A.; And Others

    1978-01-01

    Describes a multi-project pack on central heating systems, developed into an educational game, used for teaching a variety of subjects in high school. The students examine the basic decision to install a central heating system, for a particular house, and the economics involved. (GA)

  2. Central line infections - hospitals

    MedlinePlus

    ... infection; CVC - infection; Central venous device - infection; Infection control - central line infection; Nosocomial infection - central line infection; Hospital acquired infection - central line infection; Patient safety - central ...

  3. Realigning the Orbits of Central Office and Schools

    ERIC Educational Resources Information Center

    Larson, Eliot W.

    2007-01-01

    This article discusses why the work of central-office administrators and building administrators seem so disconnected from one another. The fact that central-office administrators and principals seem to travel in orbits with different paths, with seemingly few areas of significant overlap, has a decidedly negative impact on the ability of the…

  4. Veterans Health Administration

    MedlinePlus

    ... code here VA » Veterans Health Administration Veterans Health Administration Marine Continues to Serve by Serving Veterans David ... Read more » VA Medical Centers The Veterans Health Administration is home to the United States’ largest integrated ...

  5. Heat-related illness.

    PubMed

    Becker, Jonathan A; Stewart, Lynsey K

    2011-06-01

    Heat-related illness is a set of preventable conditions ranging from mild forms (e.g., heat exhaustion, heat cramps) to potentially fatal heat stroke. Hot and humid conditions challenge cardiovascular compensatory mechanisms. Once core temperature reaches 104°F (40°C), cellular damage occurs, initiating a cascade of events that may lead to organ failure and death. Early recognition of symptoms and accurate measurement of core temperature are crucial to rapid diagnosis. Milder forms of heat-related illness are manifested by symptoms such as headache, weakness, dizziness, and an inability to continue activity. These are managed by supportive measures including hydration and moving the patient to a cool place. Hyperthermia and central nervous system symptoms should prompt an evaluation for heat stroke. Initial treatments should focus on lowering core temperature through cold water immersion. Applying ice packs to the head, neck, axilla, and groin is an alternative. Additional measures include transporting the patient to a cool environment, removing excess clothing, and intravenous hydration. Delayed access to cooling is the leading cause of morbidity and mortality in persons with heat stroke. Identification of at-risk groups can help physicians and community health agencies provide preventive measures.

  6. 30 CFR 57.4500 - Heat sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Heat sources. 57.4500 Section 57.4500 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Installation/construction/maintenance § 57.4500 Heat sources. Heat sources capable of producing...

  7. 30 CFR 56.4500 - Heat sources.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Heat sources. 56.4500 Section 56.4500 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND... Installation/construction/maintenance § 56.4500 Heat sources. Heat sources capable of producing...

  8. 30 CFR 57.4500 - Heat sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Installation/construction/maintenance § 57.4500 Heat sources. Heat sources capable of producing combustion... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Heat sources. 57.4500 Section 57.4500 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY...

  9. 30 CFR 56.4500 - Heat sources.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Installation/construction/maintenance § 56.4500 Heat sources. Heat sources capable of producing combustion... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Heat sources. 56.4500 Section 56.4500 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY...

  10. [Pathophysiology of heat illness].

    PubMed

    Aruga, Tohru; Miyake, Yasufumi

    2012-06-01

    Human core temperature is strictly controlled by mechanism of radiation, conduction, convection, and evaporation from skin surface. Serial hot and humid climate induces dehydration which interferes heat pump-out from the body. Heart dysfunction is the third factor to rise body temperature. Hyperthermia and hypo-perfusion caused by dehydration and heart failure deteriorate specific organ functions, i.e. central nervous system, liver and renal functions and coagulation system. Disseminated intravascular coagulopathy is one of the standard indicators of severity and mortality of heat stroke.

  11. Heat Illness

    MedlinePlus

    ... symptoms include heavy sweating, rapid breathing and a fast, weak pulse Heat cramps - muscle pains or spasms that happen during heavy exercise Heat rash - skin irritation from excessive sweating Centers for Disease Control and Prevention

  12. Heat Stress

    MedlinePlus

    ... Stress Learn some tips to protect workers including: acclimatization, rest breaks, and fluid recommendations. NIOSH Workplace Solution: ... Blog: Adjusting to Work in the Heat: Why Acclimatization Matters The natural adaptation to the heat takes ...

  13. Extreme Heat

    MedlinePlus

    ... Emergencies Biological Threats Chemical Threats Cyber Incident Drought Earthquakes Extreme Heat Explosions Floods Hazardous Materials Incidents Home ... Emergencies Biological Threats Chemical Threats Cyber ... Heat Explosions Floods Hazardous Materials Incidents Home ...

  14. Industrial heat pump assessment study

    NASA Astrophysics Data System (ADS)

    Chappell, R. N.; Priebe, S. J.; Wilfert, G. L.

    1989-03-01

    This report summarizes preliminary studies that assess the potential of industrial heat pumps for reduction of process heating requirements in industries receiving power from the Bonneville Power Administration (BPA). This project was initiated at the request of BPA to determine the potential of industrial heat pumps in BPA's service area. Working from known heat pump principles and from a list of BPA's industrial customers, the authors estimated the fuel savings potential for six industries. Findings indicate that the pulp and paper industry would yield the greatest fuel savings and increased electrical consumption. Assessments presented in this report represent a cooperative effort between The Idaho National Engineering Laboratory (INEL), and Battelle-Northwest Laboratories.

  15. INTERIOR OF CENTRAL ROOM OF PAINT SHOP PORTION OF BUILDING, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR OF CENTRAL ROOM OF PAINT SHOP PORTION OF BUILDING, FACING SOUTHEAST - Vancouver Barracks, Paint Shop and Central Heating Plant, East Fifth Street southeast of McLoughlin Road, Vancouver, Clark County, WA

  16. Heat exchanger

    DOEpatents

    Daman, Ernest L.; McCallister, Robert A.

    1979-01-01

    A heat exchanger is provided having first and second fluid chambers for passing primary and secondary fluids. The chambers are spaced apart and have heat pipes extending from inside one chamber to inside the other chamber. A third chamber is provided for passing a purge fluid, and the heat pipe portion between the first and second chambers lies within the third chamber.

  17. Central solar energy receiver

    DOEpatents

    Drost, M. Kevin

    1983-01-01

    An improved tower-mounted central solar energy receiver for heating air drawn through the receiver by an induced draft fan. A number of vertically oriented, energy absorbing, fin-shaped slats are radially arranged in a number of concentric cylindrical arrays on top of the tower coaxially surrounding a pipe having air holes through which the fan draws air which is heated by the slats which receive the solar radiation from a heliostat field. A number of vertically oriented and wedge-shaped columns are radially arranged in a number of concentric cylindrical clusters surrounding the slat arrays. The columns have two mirror-reflecting sides to reflect radiation into the slat arrays and one energy absorbing side to reduce reradiation and reflection from the slat arrays.

  18. Management Team Stressors and Their Impact on Administrators' Health.

    ERIC Educational Resources Information Center

    Gmelch, Walter H.; Swent, Boyd

    School administrators suffer greater stress from administrative constraints than from any other stress factors, according to a survey of over 1,150 Oregon elementary and secondary principals and vice-principals, superintendents, and central office administrators. Researchers isolated 35 stressors, or stress-inducing situations, that could be…

  19. 75 FR 27227 - Energy Conservation Program: Energy Conservation Standards for Residential Central Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ... Central Air Conditioners and Heat Pumps AGENCY: Department of Energy, Office of Energy Efficiency and... conservation standards for residential central air conditioners and heat pumps; the analytical framework... preliminary technical support document for central air conditioners and heat pumps. The comment period...

  20. Central control of body temperature

    PubMed Central

    Morrison, Shaun F.

    2016-01-01

    Central neural circuits orchestrate the behavioral and autonomic repertoire that maintains body temperature during environmental temperature challenges and alters body temperature during the inflammatory response and behavioral states and in response to declining energy homeostasis. This review summarizes the central nervous system circuit mechanisms controlling the principal thermoeffectors for body temperature regulation: cutaneous vasoconstriction regulating heat loss and shivering and brown adipose tissue for thermogenesis. The activation of these thermoeffectors is regulated by parallel but distinct efferent pathways within the central nervous system that share a common peripheral thermal sensory input. The model for the neural circuit mechanism underlying central thermoregulatory control provides a useful platform for further understanding of the functional organization of central thermoregulation, for elucidating the hypothalamic circuitry and neurotransmitters involved in body temperature regulation, and for the discovery of novel therapeutic approaches to modulating body temperature and energy homeostasis. PMID:27239289

  1. Pioneering Heat Pump Project

    SciTech Connect

    Aschliman, Dave; Lubbehusen, Mike

    2015-06-30

    This project was initiated at a time when ground coupled heat pump systems in this region were limited in size and quantity. There were economic pressures with costs for natural gas and electric utilities that had many organizations considering ground coupled heat pumps; The research has added to the understanding of how ground temperatures fluctuate seasonally and how this affects the performance and operation of the heat pumps. This was done by using a series of temperature sensors buried within the middle of one of the vertical bore fields with sensors located at various depths below grade. Trending of the data showed that there is a lag in ground temperature with respect to air temperatures in the shoulder months, however as full cooling and heating season arrives, the heat rejection and heat extraction from the ground has a significant effect on the ground temps; Additionally it is better understood that while a large community geothermal bore field serving multiple buildings does provide a convenient central plant to use, it introduces complexity of not being able to easily model and predict how each building will contribute to the loads in real time. Additional controllers and programming were added to provide more insight into this real time load profile and allow for intelligent shedding of load via a dry cooler during cool nights in lieu of rejecting to the ground loop. This serves as a means to ‘condition’ the ground loop and mitigate thermal creep of the field, as is typically observed; and It has been observed when compared to traditional heating and cooling equipment, there is still a cost premium to use ground source heat pumps that is driven mostly by the cost for vertical bore holes. Horizontal loop systems are less costly to install, but do not perform as well in this climate zone for heating mode

  2. Heat Pipes

    NASA Technical Reports Server (NTRS)

    1996-01-01

    Heat Pipes were originally developed by NASA and the Los Alamos Scientific Laboratory during the 1960s to dissipate excessive heat build- up in critical areas of spacecraft and maintain even temperatures of satellites. Heat pipes are tubular devices where a working fluid alternately evaporates and condenses, transferring heat from one region of the tube to another. KONA Corporation refined and applied the same technology to solve complex heating requirements of hot runner systems in injection molds. KONA Hot Runner Systems are used throughout the plastics industry for products ranging in size from tiny medical devices to large single cavity automobile bumpers and instrument panels.

  3. Paine Appointed Administrator

    NASA Technical Reports Server (NTRS)

    1969-01-01

    President Richard M. Nixon announcing the appointment of Dr. Thomas O. Paine as Administrator for the National Aeronautics and Space Administration. The ceremony was held at the White House. Paine had been serving as acting administrator. From left to right: President Richard M. Nixon NASA Administrator Dr. Thomas O. Paine Vice President Spiro T. Agnew

  4. Central Statistical Libraries in Europe.

    ERIC Educational Resources Information Center

    Kaiser, Lisa

    The paper tries to clarify the position special governmental libraries hold in the system of libraries of today by investigating only one specific type of library mainly from a formal and historical point of view. Central statistical libraries in Europe were first regarded as administrative and archival libraries. Their early holdings of foreign…

  5. Heat pipe thermal switch

    NASA Technical Reports Server (NTRS)

    Wolf, D. A. (Inventor)

    1983-01-01

    A thermal switch for controlling the dissipation of heat between a body is described. The thermal switch is comprised of a flexible bellows defining an expansible vapor chamber for a working fluid located between an evaporation and condensation chamber. Inside the bellows is located a coiled retaining spring and four axial metal mesh wicks, two of which have their central portions located inside of the spring while the other two have their central portions located between the spring and the side wall of the bellows. The wicks are terminated and are attached to the inner surfaces of the outer end walls of evaporation and condensation chambers respectively located adjacent to the heat source and heat sink. The inner surfaces of the end walls furthermore include grooves to provide flow channels of the working fluid to and from the wick ends. The evaporation and condensation chambers are connected by turnbuckles and tension springs to provide a set point adjustment for setting the gap between an interface plate on the condensation chamber and the heat sink.

  6. Central Italy

    NASA Technical Reports Server (NTRS)

    1981-01-01

    Clouds and haze cover most of the Italian peninsula in this view of central Italy (41.5N, 14.0E) but the Bay of Naples region with Mt. Vesuvius and the island of Capri are clear. The Adriatic Sea in the background separates Italy from the cloud covered Balkans of eastern Europe and the Tyrrhenian Sea in the foreground lies between the Italian mainland and the off scene islands of Corsica and Sardinia. Several aircraft contrails can also be seen.

  7. Spatial variation of temperature and indicative of the urban heat island in Chennai Metropolitan Area, India

    NASA Astrophysics Data System (ADS)

    Jeganathan, Anushiya; Andimuthu, Ramachandran; Prasannavenkatesh, Ramachandran; Kumar, Divya Subash

    2016-01-01

    Heat island is the main product of urban climate, and one of the important problems of twenty-first century. Cities in tropical countries suffer extensively due to the urban heat island effect, and urban climate studies are necessary to improve the comfort level and city planning. Chennai is the tropical city; it is the fourth largest metropolis in India and one of the fastest growing economic and industrial growth centers in South Asia. The spatial distribution of heat intensity in Chennai Metropolitan Area was studied, and the influence of land use and green cover were analyzed in the present work. Mobile measurements were carried out throughout the study area using a grid network to represent various land use patterns of the city. The study revealed some heat and cool pockets within the city limit; the maximum intensities of temperature were noticed in the central core city and north Chennai, which are distinguished for their commercial centers and densely populated residential areas. In morning time, temperature differences between fringes and central parts of heat packets were in the range of 3-4.5 °C. Land use and green cover play a critical role in microclimate and influences it. Green cover has a significant negative correlation with observed microclimate variations. Thus, the study urges city administration, policy makers, and architects to take up effective mitigation and adaptation strategies in the city to make people more comfortable.

  8. Transportation Security Administration

    MedlinePlus

    ... content Official website of the Department of Homeland Security Transportation Security Administration A - Z Index What Can I Bring? ... form Search the Site Main menu Administrator Travel Security Screening Special Procedures TSA Pre✓® Passenger Support Travel ...

  9. Administration on Aging

    MedlinePlus

    ... Federal Initiatives Career Opportunities Contact Us Administration on Aging (AoA) The Administration on Aging (AOA) is the ... themselves. Back to top Older Americans Act and Aging Network To meet the diverse needs of the ...

  10. Rehabilitation Services Administration

    MedlinePlus

    ... Contacts OSEP Reports & Resources RSA Welcome to RSA Rehabilitation Services Administration RSA Spotlight News Commissioner's Quarterly Newsletter ... The Office of Special Education and Rehabilitative Services’ Rehabilitation Services Administration is proud to announce the publication ...

  11. Administration on Aging

    MedlinePlus

    ... Administration on Aging Administration on Disabilities Center for Integrated Programs Center for Performance and Evaluation National Institute ... Project Aging Statistics Profile of Older Americans AGing Integrated Database (AGID) Census Data & Population Estimates Projected Future ...

  12. Lung cancer and indoor pollution from heating and cooking with solid fuels: the IARC international multicentre case-control study in Eastern/Central Europe and the United Kingdom.

    PubMed

    Lissowska, Jolanta; Bardin-Mikolajczak, Alicja; Fletcher, Tony; Zaridze, David; Szeszenia-Dabrowska, Neonila; Rudnai, Peter; Fabianova, Eleonora; Cassidy, Adrian; Mates, Dana; Holcatova, Ivana; Vitova, Vera; Janout, Vladimir; Mannetje, Andrea't; Brennan, Paul; Boffetta, Paolo

    2005-08-15

    Exposure to fuel from cooking and heating has not been studied in Europe, where lung cancer rates are high and many residents have had a long tradition of burning coal and unprocessed biomass. Study subjects included 2,861 cases and 3,118 controls recruited during 1998-2002 in the Czech Republic, Hungary, Poland, Romania, Russia, Slovakia, and the United Kingdom. The odds ratio of lung cancer associated with solid fuel use was 1.22 (95% confidence interval (CI): 1.04, 1.44) for cooking or heating, 1.37 (95% CI: 0.90, 2.09) for solid fuel only for cooking, and 1.24 (95% CI: 1.05, 1.47) for solid fuels used for both cooking and heating. Risk increased relative to the percentage of time that solid fuel was used for cooking (p(trend) < 0.0001), while no risk increase was detected for solid fuel used for heating. The odds ratio of lung cancer in whole-life users of solid cooking fuel was 1.80 (95% CI: 1.35, 2.40). Switching to nonsolid fuels resulted in a decrease in risk. The odds ratio for the longest duration of time since switching was 0.76 (95% CI: 0.63, 0.92). The data suggest a modest increased risk of lung cancer related to solid-fuel use for cooking rather than heating.

  13. Legal and Administrative Language

    ERIC Educational Resources Information Center

    Schwarz, Hans

    1977-01-01

    A discussion of legal and administrative language, and the necessity for accurate translation of this language in the field of international relations. Topics treated are: characteristic features of legal and administrative terminology; the interpretation of it; and the technique of translating legal and administrative texts. (AMH)

  14. Women in Administration 1978.

    ERIC Educational Resources Information Center

    National Association of State Universities and Land Grant Colleges, Washington, DC. Office of Communications Services.

    In a survey by the National Association of State Universities and Land-Grant Colleges (NASULGC), women are shown to hold 2,905 of the 13,638 administrative positions reported by 106 major U.S. public universities--slightly more than 21 percent of the administrators at state and land-grant universities. The median number of women administrators at…

  15. School Business Administration.

    ERIC Educational Resources Information Center

    Jordan, K. Forbis; And Others

    This textbook reviews the principal concerns within each of 13 major responsibility areas in school business administration. The first chapter assesses the political, social, and economic context in which schools function and school administrators work. The role and function of the school business administrator within this context is addressed in…

  16. Heat Problems.

    ERIC Educational Resources Information Center

    Connors, G. Patrick

    Heat problems and heat cramps related to jogging can be caused by fluid imbalances, medications, dietary insufficiency, vomiting or diarrhea, among other factors. If the condition keeps reoccurring, the advice of a physician should be sought. Some preventive measures that can be taken include: (1) running during the cooler hours of the day; (2)…

  17. The School Administrator Payoff from Teacher Pensions

    ERIC Educational Resources Information Center

    Koedel, Cory; Ni, Shawn; Podgursky, Michael

    2013-01-01

    It is widely recognized that teacher quality is the central input in school performance. This insight has put human resource and compensation policies, including performance pay, tenure, alternative route recruitment, and mentoring, at center stage in school reform debates. Some school administrators have been innovators and reform leaders in…

  18. 45 CFR 30.12 - Administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... debt. (2) This section does not apply to: (i) Debts arising under the Social Security Act, except as provided in 42 U.S.C. 404; (ii) Payments made under the Social Security Act, except as provided for in 31 U...-centralized administrative offset internally or in cooperation with the agency certifying or...

  19. 75 FR 43166 - Information Collection; Central Contractor Registration Requirements for Prime Grant Recipients

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... ADMINISTRATION Information Collection; Central Contractor Registration Requirements for Prime Grant Recipients... emergency new information collection requirement regarding Central Contractor Registration Requirements for... information is necessary for the proper performance of functions of the Central Contractor...

  20. Central Station DHC Phase 1 feasibility

    SciTech Connect

    Henderson, H.L.

    1992-03-01

    This project assisted a private real estate developer in technically assessing the feasibility of integrating a central DHC system into a proposed 72 acre area mixed-use Planned Development (Central Station) just south of the Chicago Central Business District (Loop). The technical assessment concluded that a district heating and cooling system for Central Station will be feasible, provided that a major anchor load can be connected to the system. The system conceived for the site employs a modular approach that adjusts production capacity to actual load growth. The design concept includes gas-fired boilers for heating, gas turbine driven chillers for base loading, electric motor driven chillers for peaking, steam turbines for peak power and back pressure operation, and chilled water storage. Energy will be supplied to the users in the form of steam or low temperature hot water for heating, and low temperature chilled water for cooling.

  1. Central pain.

    PubMed

    Singh, Supreet

    2014-12-01

    Questions from patients about pain conditions and analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. The topic addressed in this issue is central pain, a neuropathic pain syndrome caused by a lesion in the brain or spinal cord that sensitizes one's perception of pain. It is a debilitating condition caused by various diseases such as multiple sclerosis, strokes, spinal cord injuries, or brain tumors. Varied symptoms and the use of pharmacological medicines and nonpharmacological therapies will be addressed.

  2. Bonneville Power Administration Weatherize Program; Approved Products List (APL), June 1994.

    SciTech Connect

    United States. Bonneville Power Administration

    1994-06-01

    This document contains a listing of approved products and manufacturers for the Bonneville Power Administration`s Weatherwise Program. Product listing are arranged by sections and include: Storm windows; Weatherstripping; Caulking; Insulation; Thermostats; and Air-to-air heat exchangers.

  3. Development of a heat pipe heat dissipation method for CPV application

    NASA Astrophysics Data System (ADS)

    Moon, Seok-Hwan; Lee, Kyu-Ho; Hong, Soo-Hyun; Ko, Sang-Choon; Jun, Chi-Hoon; Mun, Jae-Kyoung; Park, Ki-Sung; Park, Jun-Hee

    2014-09-01

    Even when there is a sufficient heat dissipation area from the heat sink to the environment, if the heat flux in the chip package substrate cannot be transferred rapidly to the heat sink, a thermal problem may occur.[1] In this study, a relatively thin CPV module compared to general models was considered. Because four solar chips are mounted on a center column in the CPV module, heat can accumulate rapidly. Therefore, a heat pipe with high thermal conductivity was considered as the heat dissipation method.[2] The heat pipe adopted in the present study is commercially available and has a circular type sintered wick in it. To apply the heat pipe to the CPV module with thin thickness and a central column with 4 solar cells, it should be pressed and bent. The thermal characteristics of the pressed and bent heat pipe was investigated experimentally.

  4. Challenges and Opportunities for the Obama Administration in Central Asia

    DTIC Science & Technology

    2009-06-01

    in law, development, peacemaking, and the creation of lasting 20 democratic institutions.”67 Likewise, it is essential to invest in regional... essential to persuade local participants that U.S. aims are not inimical to their own but rather in sync with them. As Sir Michael Howard wrote in 2003...Nezavisimaya Gazeta, in Russian, November 28, 2007, FBIS SOV November 28, 2007; Bulat Abdulin, “For Kazakhstan’s Army—A NATO Heading,” Marketing I

  5. 7 CFR 3.44 - Centralized administrative offset.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... TINs of debtors who owe debts referred to Treasury under this section shall be compared to the names and TINs on payments to be made by Federal disbursing officials. Federal disbursing officials include... and TIN of a debtor match the name and TIN of a payee and all other requirements for offset have...

  6. 7 CFR 3.44 - Centralized administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... TINs of debtors who owe debts referred to Treasury under this section shall be compared to the names and TINs on payments to be made by Federal disbursing officials. Federal disbursing officials include... and TIN of a debtor match the name and TIN of a payee and all other requirements for offset have...

  7. Heat collector

    DOEpatents

    Merrigan, Michael A.

    1984-01-01

    A heat collector and method suitable for efficiently and cheaply collecting solar and other thermal energy are provided. The collector employs a heat pipe in a gravity-assist mode and is not evacuated. The collector has many advantages, some of which include ease of assembly, reduced structural stresses on the heat pipe enclosure, and a low total materials cost requirement. Natural convective forces drive the collector, which after startup operates entirely passively due in part to differences in molecular weights of gaseous components within the collector.

  8. Heat collector

    DOEpatents

    Merrigan, M.A.

    1981-06-29

    A heat collector and method suitable for efficiently and cheaply collecting solar and other thermal energy are provided. The collector employs a heat pipe in a gravity-assist mode and is not evacuated. The collector has many advantages, some of which include ease of assembly, reduced structural stresses on the heat pipe enclosure, and a low total materials cost requirement. Natural convective forces drive the collector, which after startup operates entirely passively due in part to differences in molecular weights of gaseous components within the collector.

  9. Heat Pipes and Heat Rejection Component Testing at NASA Glenn Research Center

    NASA Technical Reports Server (NTRS)

    Sanzi, James L.; Jaworske, Donald A.

    2012-01-01

    Titanium-water heat pipes are being evaluated for use in the heat rejection system for space fission power systems. The heat rejection syst em currently comprises heat pipes with a graphite saddle and a composite fin. The heat input is a pumped water loop from the cooling of the power conversion system. The National Aeronautics and Space Administration has been life testing titanium-water heat pipes as well as eval uating several heat pipe radiator designs. The testing includes thermal modeling and verification of model, material compatibility, frozen startup of heat pipe radiators, and simulating low-gravity environments. Future thermal testing of titanium-water heat pipes includes low-g ravity testing of thermosyphons, radiation testing of heat pipes and fin materials, water pump performance testing, as well as Small Busine ss Innovation Research funded deliverable prototype radiator panels.

  10. Hydraulic friction heat generator

    SciTech Connect

    McMurtry, R.V.

    1987-08-11

    A hydraulic friction heat generator filled with hydraulic heat transfer fluid is described which consists of: a cylindrical housing with a central axis through its interior and with end plates generally normal to the central axis, the generator having an inlet conduit means and an outlet conduit means located at opposite ends of the cylindrical housing thereof; a drive shaft bearingly mounted in each of the end plates in coaxial alignment with the central axis and passing through one of the end plates to extend outwardly therefrom; an external power source joined to the extended shaft for rotating the shaft; and smooth-surfaced thin discs with outer generally annular peripheral edges closely-spaced from the inner wall of the cylindrical housing, the discs being fixedly mounted in axially spaced relationship on the drive shaft to be rotated thereby in a single direction, with no stationary elements interposed between the discs, each disc having at least two radially-oriented slits partially transecting the disc to extend inward from the disc peripheral edges, and the discs having a portion of each disc on one side of the slit feathered outward from the plane of the disc to form a vane for turbulently forcing the hydraulic fluid axially toward the outlet conduit means.

  11. Corrosive resistant heat exchanger

    DOEpatents

    Richlen, Scott L.

    1989-01-01

    A corrosive and errosive resistant heat exchanger which recovers heat from a contaminated heat stream. The heat exchanger utilizes a boundary layer of innocuous gas, which is continuously replenished, to protect the heat exchanger surface from the hot contaminated gas. The innocuous gas is conveyed through ducts or perforations in the heat exchanger wall. Heat from the heat stream is transferred by radiation to the heat exchanger wall. Heat is removed from the outer heat exchanger wall by a heat recovery medium.

  12. HEAT EXCHANGER

    DOEpatents

    Fox, T.H. III; Richey, T. Jr.; Winders, G.R.

    1962-10-23

    A heat exchanger is designed for use in the transfer of heat between a radioactive fiuid and a non-radioactive fiuid. The exchanger employs a removable section containing the non-hazardous fluid extending into the section designed to contain the radioactive fluid. The removable section is provided with a construction to cancel out thermal stresses. The stationary section is pressurized to prevent leakage of the radioactive fiuid and to maintain a safe, desirable level for this fiuid. (AEC)

  13. Sodium heat transfer system modeling

    NASA Astrophysics Data System (ADS)

    Baker, A. F.; Fewell, M. E.

    1983-11-01

    The sodium heat transfer system of the international energy agency (IEA) small solar power systems (SSPS) central receiver system (CRS), which includes the heliostat field, receiver, hot and cold storage vessels, and sodium/water steam generator was modeled. The computer code SOLTES (simulator of large thermal energy systems), was used to model this system. The results from SOLTES are compared to measured data.

  14. Heat flow in Oklahoma

    SciTech Connect

    Cranganu, C.; Deming, D.

    1996-12-31

    Oklahoma is one area in which terrestrial heat flow data are sparse. The thermal state of the southern mid-continent, however, is a key to understanding several important geologic problems. These include thermal anomalies associated with Paleozoic fluid migrations and the formation of Mississippi Valley-type lead-zinc deposits, the thermal evolution of the Arkoma and Anadarko sedimentary basins, and the history of hydrocarbon generation and overpressuring in the Anadarko Basin. In the late 1920s, the American Petroleum Institute made a set of equilibrium temperature logs in idle oil wells. These temperature data are generally regarded as being high quality, accurate estimates of rock temperature and they cover the entire central part of Oklahoma. Average thermal gradients in the API survey range from 14 to 43 {sup 0}C/km (average 31.2 {sup 0}C/km) over depth intervals that extend from the surface to a an average depth of 961 m. Geothermal gradients decrease from NNE to SSW. The observed change in thermal gradients could be due to a number of factors. The change in thermal gradients could simply reflect changes in lithology and thermal conductivity. Alternatively, the variation in thermal gradients could be indicative of a change in heat flow related perhaps to variations in the concentration of radioactive heat-producing elements in the crust or heat transport by one or more regional groundwater flow systems. We are proceeding to reduce ambiguity in interpretation by estimating heat flow from thermal conductivity measurements on drill cuttings and heat production from available gamma-ray logs which penetrate basement rocks.

  15. Heat flow in Oklahoma

    SciTech Connect

    Cranganu, C.; Deming, D. )

    1996-01-01

    Oklahoma is one area in which terrestrial heat flow data are sparse. The thermal state of the southern mid-continent, however, is a key to understanding several important geologic problems. These include thermal anomalies associated with Paleozoic fluid migrations and the formation of Mississippi Valley-type lead-zinc deposits, the thermal evolution of the Arkoma and Anadarko sedimentary basins, and the history of hydrocarbon generation and overpressuring in the Anadarko Basin. In the late 1920s, the American Petroleum Institute made a set of equilibrium temperature logs in idle oil wells. These temperature data are generally regarded as being high quality, accurate estimates of rock temperature and they cover the entire central part of Oklahoma. Average thermal gradients in the API survey range from 14 to 43 [sup 0]C/km (average 31.2 [sup 0]C/km) over depth intervals that extend from the surface to a an average depth of 961 m. Geothermal gradients decrease from NNE to SSW. The observed change in thermal gradients could be due to a number of factors. The change in thermal gradients could simply reflect changes in lithology and thermal conductivity. Alternatively, the variation in thermal gradients could be indicative of a change in heat flow related perhaps to variations in the concentration of radioactive heat-producing elements in the crust or heat transport by one or more regional groundwater flow systems. We are proceeding to reduce ambiguity in interpretation by estimating heat flow from thermal conductivity measurements on drill cuttings and heat production from available gamma-ray logs which penetrate basement rocks.

  16. Veterans Administration Databases

    Cancer.gov

    The Veterans Administration Information Resource Center provides database and informatics experts, customer service, expert advice, information products, and web technology to VA researchers and others.

  17. 29 CFR 1919.16 - Heat treatment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Heat treatment. 1919.16 Section 1919.16 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) GEAR CERTIFICATION Certification of Vessels' Cargo Gear § 1919.16 Heat treatment. (a) All chains...

  18. Magnetar Heating

    NASA Astrophysics Data System (ADS)

    Beloborodov, Andrei M.; Li, Xinyu

    2016-12-01

    We examine four candidate mechanisms that could explain the high surface temperatures of magnetars. (1) Heat flux from the liquid core heated by ambipolar diffusion. It could sustain the observed surface luminosity {{\\mathscr{L}}}s≈ {10}35 erg s-1 if core heating offsets neutrino cooling at a temperature {T}{core}\\gt 6× {10}8 K. This scenario is viable if the core magnetic field exceeds 1016 G and the heat-blanketing envelope of the magnetar has a light-element composition. However, we find that the lifetime of such a hot core should be shorter than the typical observed lifetime of magnetars. (2) Mechanical dissipation in the solid crust. This heating can be quasi-steady, powered by gradual (or frequent) crustal yielding to magnetic stresses. We show that it obeys a strong upper limit. As long as the crustal stresses are fostered by the field evolution in the core or Hall drift in the crust, mechanical heating is insufficient to sustain persistent {{\\mathscr{L}}}s≈ {10}35 erg s-1. The surface luminosity is increased in an alternative scenario of mechanical deformations triggered by external magnetospheric flares. (3) Ohmic dissipation in the crust, in volume or current sheets. This mechanism is inefficient because of the high conductivity of the crust. Only extreme magnetic configurations with crustal fields B\\gt {10}16 G varying on a 100 meter scale could provide {{\\mathscr{L}}}s≈ {10}35 erg s-1. (4) Bombardment of the stellar surface by particles accelerated in the magnetosphere. This mechanism produces hot spots on magnetars. Observations of transient magnetars show evidence of external heating.

  19. Directory of Energy Information Administration models 1996

    SciTech Connect

    1996-07-01

    This directory revises and updates the Directory of Energy Information Administration Models 1995, DOE/EIA-0293(95), Energy Information Administration (EIA), U.S. Department of Energy, July 1995. Four models have been deleted in this directory as they are no longer being used: (1) Market Penetration Model for Ground-Water Heat Pump Systems (MPGWHP); (2) Market Penetration Model for Residential Rooftop PV Systems (MPRESPV-PC); (3) Market Penetration Model for Active and Passive Solar Technologies (MPSOLARPC); and (4) Revenue Requirements Modeling System (RRMS).

  20. Migrant Education Administrative Guide.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Compensatory Education.

    Relating specifically to the North Carolina migrant education program's administrative responsibilities, this guide is designed to aid administrators in program management, monitoring project activities, project evaluation, self-assessment, determining needs for training and staff development, site-visit preparation, policy development, and…

  1. Champions of Children. Administrators . . .

    ERIC Educational Resources Information Center

    Chaffee, John; Olds, H. Robert

    Today, in an era of taxpayer revolts, lack of clarity in values, and changing family structure, children need advocates in the political arena as well as in the schools. This pamphlet suggests that administrators are in an excellent position to defend the rights of children on all fronts. It focuses on what administrators have done and specific…

  2. The Administrative Power Grab

    ERIC Educational Resources Information Center

    Sorenson, Richard D.

    2007-01-01

    Administrative power for some school teachers can be an aphrodisiac that can be applied negatively, especially when a leader has devastating instinct for the weaknesses of others. A leader's intellect and heart closes shop and ceases to function when drunk on power. In this article, the author describes how the use of administrative power can be…

  3. Traditionalism and Educational Administration.

    ERIC Educational Resources Information Center

    Holmes, Mark

    Administration is defined as the enactment of moral choices influencing subordinates within an organizational setting. It is distinguished from management, which is considered to involve a lower level of discretion. Educational administration is therefore in the moral domain; it involves discretionary, moral choices in a field that is itself moral…

  4. Test Administration Models

    ERIC Educational Resources Information Center

    Becker, Kirk A.; Bergstrom, Betty A.

    2013-01-01

    The need for increased exam security, improved test formats, more flexible scheduling, better measurement, and more efficient administrative processes has caused testing agencies to consider converting the administration of their exams from paper-and-pencil to computer-based testing (CBT). Many decisions must be made in order to provide an optimal…

  5. The Administrative Team.

    ERIC Educational Resources Information Center

    Ohio Association of Elementary School Principals, Westerville.

    Although needs of school districts vary with size, degree of teacher negotiation procedures, and type of community involvement, the administrative team model is presented as an effective, appropriate administrative organization. Based on an assumption that each level of authority in a school district possesses and exercises expertise and unique…

  6. Administrative Theory in Transition.

    ERIC Educational Resources Information Center

    Griffiths, Daniel E.

    This monograph analyzes transition in educational administrative theory. A brief introductory section describes the theoretical movement, the substance and repercussions of Thomas Greenfield's critique of educational administrative theory in 1974, and emerging qualitative approaches. Seven readings, all written by the volume's author, view…

  7. Improving Educational Administrative Decisions.

    ERIC Educational Resources Information Center

    Wolfe, A. E.

    This paper discusses the financial crisis facing public education in the United States today and argues that the most effective response to this crisis is to improve the decision-making skills of educational administrators. Based on a review of the literature on administrative decision-making and organizational change, the author examines several…

  8. Rural Administrative Leadership Handbook.

    ERIC Educational Resources Information Center

    Tift, Carolyn

    This resource book on rural administrative leadership is the result of 1988 interviews with school administrators involved in successful rural educational programs. The material is divided into eight chapters, each self-contained for separate use. Chapter 1, "Getting to Know the Community," addresses qualities of living and working in…

  9. Heat Pipes

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Bobs Candies, Inc. produces some 24 million pounds of candy a year, much of it 'Christmas candy.' To meet Christmas demand, it must produce year-round. Thousands of cases of candy must be stored a good part of the year in two huge warehouses. The candy is very sensitive to temperature. The warehouses must be maintained at temperatures of 78-80 degrees Fahrenheit with relative humidities of 38- 42 percent. Such precise climate control of enormous buildings can be very expensive. In 1985, energy costs for the single warehouse ran to more than $57,000 for the year. NASA and the Florida Solar Energy Center (FSEC) were adapting heat pipe technology to control humidity in building environments. The heat pipes handle the jobs of precooling and reheating without using energy. The company contacted a FSEC systems engineer and from that contact eventually emerged a cooperative test project to install a heat pipe system at Bobs' warehouses, operate it for a period of time to determine accurately the cost benefits, and gather data applicable to development of future heat pipe systems. Installation was completed in mid-1987 and data collection is still in progress. In 1989, total energy cost for two warehouses, with the heat pipes complementing the air conditioning system was $28,706, and that figures out to a cost reduction.

  10. Heat Pipes

    NASA Astrophysics Data System (ADS)

    1990-01-01

    Bobs Candies, Inc. produces some 24 million pounds of candy a year, much of it 'Christmas candy.' To meet Christmas demand, it must produce year-round. Thousands of cases of candy must be stored a good part of the year in two huge warehouses. The candy is very sensitive to temperature. The warehouses must be maintained at temperatures of 78-80 degrees Fahrenheit with relative humidities of 38- 42 percent. Such precise climate control of enormous buildings can be very expensive. In 1985, energy costs for the single warehouse ran to more than 57,000 for the year. NASA and the Florida Solar Energy Center (FSEC) were adapting heat pipe technology to control humidity in building environments. The heat pipes handle the jobs of precooling and reheating without using energy. The company contacted a FSEC systems engineer and from that contact eventually emerged a cooperative test project to install a heat pipe system at Bobs' warehouses, operate it for a period of time to determine accurately the cost benefits, and gather data applicable to development of future heat pipe systems. Installation was completed in mid-1987 and data collection is still in progress. In 1989, total energy cost for two warehouses, with the heat pipes complementing the air conditioning system was 28,706, and that figures out to a cost reduction.

  11. Exertional heat illness: a review of the syndrome affecting racing Thoroughbreds in hot and humid climates.

    PubMed

    Brownlow, M A; Dart, A J; Jeffcott, L B

    2016-07-01

    Metabolic heat produced by Thoroughbred racehorses during racing can rapidly elevate core body temperature (1°C/min). When environmental conditions are hot and humid, the normal physiological cooling mechanisms become ineffective. The heat accumulated may exceed a critical thermal maximum (estimated to be 42°C), which may trigger a complex pathophysiological cascade with potentially lethal consequences. This syndrome has been labelled exertional heat illness (EHI). EHI is described in humans, but has not been well documented in Thoroughbred racehorses. The clinical signs described in racehorses would suggest that the pathophysiological events affecting the central nervous (CNS) and gastrointestinal systems are similar to those described in humans. Clinical signs are progressive and include signs of endotoxaemia and increasing levels of CNS dysfunction. Initially, horses that may be mildly irritable (agitated, randomly kicking out) may progress to unmanageable (disorientation, severe ataxia, falling) and ultimately convulsions, coma and death. Currently, the approach to treatment is largely empirical and involves rapid and effective cooling, administration of drugs to provide sedation, administration of non-steroidal anti-inflammatory drugs to ameliorate the effects of endotoxaemia and glucocorticoids to stabilise cell membranes and reduce the effects of inflammation on the CNS. This review provides an overview of the current knowledge about EHI in Thoroughbred racehorses, suggests a likely pathophysiology of the syndrome in horses based on the current literature on heat illness in humans and horses, and outlines current treatment strategies being used to treat racehorses with clinical signs of EHI.

  12. Future Flight Central

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA 'Future Flight Central,' the world's first full-scale virtual airport control tower, opened December 13, 1999 at NASA Ames Research Center, Moffett Field, California. Constructed at a cost of $10 million, the two story facility was jointly funded by NASA and the Federal Aviation Administration (FAA). The facility is designed to test ways to solve potential air and ground traffic problems at commercial airports under realistic airport conditions and configurations. The facility provides an opportunity for airlines and airports to mitigate passenger delays by fine tuning airport hub operations, gate management, ramp movement procedures, and various other airport improvements. Twelve rear projection screens provide a seamless 360 degree high- resolution view of the airport or other screens being depicted. The imaging system, powered by supercomputers, provides a realistic view of weather conditions, enviromental and seasonal effects and the movement of up to 200 active aircraft and ground vehicles.

  13. Today's central receiver power plant

    NASA Astrophysics Data System (ADS)

    Alpert, D. J.; Kolb, G. J.; Chavez, J. M.

    1991-04-01

    For 15 years, the United States Department of Energy has worked with industry, both utilities and manufacturers, to develop the technology of solar central receiver power plants. In this type of plant, sunlight is concentrated by a field of sun-tracking mirrors, called heliostats, onto a centrally located receiver. The solar energy is collected in the form of a heated fluid, which is used to generate steam to power a conventional turbine generator. For a number of reasons, molten nitrate salt is now the preferred heat transfer fluid. Commercial plants will be sized between 100 and 200 MW. The impetus for developing central receivers comes from their unique advantages: (1) they produce clean, reliable, low-cost electricity; (2) they have practical energy storage that provides a high degree of dispatchability (annually up to 60 percent) - without fossil fuels; and (3) they are environmentally benign. Development efforts around the world have brought the technology to the brink of commercialization: The technical feasibility has been proven, and cost, performance, and reliability can be confidently predicted. Plans are currently being developed for the final steps toward commercial central receiver power plants.

  14. 10 CFR 1015.203 - Collection by administrative offset.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... section does not apply to: (i) Debts arising under the Social Security Act (42 U.S.C. 301, et. seq.) except as provided in 42 U.S.C. 404; (ii) Payments made under the Social Security Act (42 U.S.C. 301, et... centralized administrative offset. Treasury may exempt classes of DOE payments from centralized offset...

  15. 10 CFR 1015.203 - Collection by administrative offset.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... section does not apply to: (i) Debts arising under the Social Security Act (42 U.S.C. 301, et. seq.) except as provided in 42 U.S.C. 404; (ii) Payments made under the Social Security Act (42 U.S.C. 301, et... centralized administrative offset. Treasury may exempt classes of DOE payments from centralized offset...

  16. 10 CFR 1015.203 - Collection by administrative offset.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section does not apply to: (i) Debts arising under the Social Security Act (42 U.S.C. 301, et. seq.) except as provided in 42 U.S.C. 404; (ii) Payments made under the Social Security Act (42 U.S.C. 301, et... centralized administrative offset. Treasury may exempt classes of DOE payments from centralized offset...

  17. 10 CFR 1015.203 - Collection by administrative offset.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... section does not apply to: (i) Debts arising under the Social Security Act (42 U.S.C. 301, et. seq.) except as provided in 42 U.S.C. 404; (ii) Payments made under the Social Security Act (42 U.S.C. 301, et... centralized administrative offset. Treasury may exempt classes of DOE payments from centralized offset...

  18. Profiles of School Administrators in South Korea: A Comparative Perspective

    ERIC Educational Resources Information Center

    Kim, Songmi; Kim, Eugene P.

    2005-01-01

    Research literature considering school administrators in South Korea is disappointingly sparse. A central focus of this article is to investigate vital descriptors of Korean school administrators, including demographic profiles, entry perspectives, pre-service and in-service training and career commitment. Secondarily, the findings are compared to…

  19. Interactive Education in Public Administration (2): Strategies for Teachers

    ERIC Educational Resources Information Center

    Brock, Jonathan; Alford, John

    2015-01-01

    The previous article ("Interactive education in public administration (1): The role of teaching 'objects'") described the benefits of "moving from behind the lectern" to engage in interactive teaching in public policy and administration, and the central role of "objects" in that process. But teaching…

  20. 10 CFR 431.92 - Definitions concerning commercial air conditioners and heat pumps.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... total heating output of a central air-conditioning heat pump during its normal annual usage period for... heat pump (or its produced heating effect, depending on the mode of operation) to its net work input, when both the cooling (or heating) effect and the net work input are expressed in identical units...

  1. Serendipitous detection of an errant central venous catheter

    SciTech Connect

    Orzel, J.A.; Romdall, K.; Griep, R.

    1985-09-01

    The inappropriate placement of a patient's central venous catheter in the pleural space by the serendipitous injection of Tc-99m labeled red blood cells through the catheter during a GI bleeding study was discovered. Position and patency of central venous lines can be incidentally evaluated by using existing central venous catheters for administration of radiopharmaceuticals during radionuclide imaging studies.

  2. Chromospheric heating

    NASA Technical Reports Server (NTRS)

    Kalkofen, Wolfgang

    1989-01-01

    The solar chromosphere is identified with the atmosphere inside magnetic flux tubes. Between the temperature minimum and the 7000 K level, the chromosphere in the bright points of the quiet sun is heated by large-amplitude, long-period, compressive waves with periods mainly between 2 and 4 minutes. These waves do not observe the cutoff condition according to which acoustic waves with periods longer than 3 minutes do not propagate vertically in the upper solar photosphere. It is concluded that the long-period waves probably supply all the energy required for the heating of the bright points in the quiet solar chromosphere.

  3. HEAT GENERATION

    DOEpatents

    Imhoff, D.H.; Harker, W.H.

    1963-12-01

    Heat is generated by the utilization of high energy neutrons produced as by nuclear reactions between hydrogen isotopes in a blanket zone containing lithium, a neutron moderator, and uranium and/or thorium effective to achieve multtplicatton of the high energy neutron. The rnultiplied and moderated neutrons produced react further with lithium-6 to produce tritium in the blanket. Thermal neutron fissionable materials are also produced and consumed in situ in the blanket zone. The heat produced by the aggregate of the various nuclear reactions is then withdrawn from the blanket zone to be used or otherwise disposed externally. (AEC)

  4. Ion cyclotron heating experiments in PLT

    SciTech Connect

    Mazzucato, E.; Bell, R.; Bitter, M.; Cavallo, A.; Cohen, S.; Colestock, P.; Greene, G.; Hammett, G.; Hinnov, E.; Hosea, J.

    1985-03-01

    Results from ICRF heating experiments in the D-/sup 3/He minority regime on the PLT tokamak are reported. At the highest coupled rf power of 2.6 MW, a central ion temperature of 3.6 keV has been measured in plasmas with a central density of 5 x 10/sup 13/cm/sup -3/. The central value of the electron temperature is strongly modulated by the sawtooth internal relaxation and reaches values in excess of 3 keV. No deterioration of the ion heating efficiency has been found in the investigated range of plasma parameters.

  5. Renewable Heating and Cooling

    EPA Pesticide Factsheets

    Renewable heating and cooling is a set of alternative resources and technologies that can be used in place of conventional heating and cooling technologies for common applications such as water heating, space heating, space cooling and process heat.

  6. The Impact of Winter Heating on Air Pollution in China

    PubMed Central

    Xiao, Qingyang; Ma, Zongwei; Li, Shenshen; Liu, Yang

    2015-01-01

    Fossil-fuel combustion related winter heating has become a major air quality and public health concern in northern China recently. We analyzed the impact of winter heating on aerosol loadings over China using the MODIS-Aqua Collection 6 aerosol product from 2004–2012. Absolute humidity (AH) and planetary boundary layer height (PBL) -adjusted aerosol optical depth (AOD*) was constructed to reflect ground-level PM2.5 concentrations. GIS analysis, standard statistical tests, and statistical modeling indicate that winter heating is an important factor causing increased PM2.5 levels in more than three-quarters of central and eastern China. The heating season AOD* was more than five times higher as the non-heating season AOD*, and the increase in AOD* in the heating areas was greater than in the non-heating areas. Finally, central heating tend to contribute less to air pollution relative to other means of household heating. PMID:25629878

  7. The impact of winter heating on air pollution in China.

    PubMed

    Xiao, Qingyang; Ma, Zongwei; Li, Shenshen; Liu, Yang

    2015-01-01

    Fossil-fuel combustion related winter heating has become a major air quality and public health concern in northern China recently. We analyzed the impact of winter heating on aerosol loadings over China using the MODIS-Aqua Collection 6 aerosol product from 2004-2012. Absolute humidity (AH) and planetary boundary layer height (PBL) -adjusted aerosol optical depth (AOD*) was constructed to reflect ground-level PM2.5 concentrations. GIS analysis, standard statistical tests, and statistical modeling indicate that winter heating is an important factor causing increased PM2.5 levels in more than three-quarters of central and eastern China. The heating season AOD* was more than five times higher as the non-heating season AOD*, and the increase in AOD* in the heating areas was greater than in the non-heating areas. Finally, central heating tend to contribute less to air pollution relative to other means of household heating.

  8. Flash Heating

    NASA Astrophysics Data System (ADS)

    Taylor, G. J.

    2000-03-01

    Meteorites contain millimeter-sized objects called chondrules. They were melted in the solar nebula, the cloud of gas and dust in which the Sun and planets formed. Numerous experiments on rock powders have been done to understand the melting process and the cooling rates chondrules experienced. Most meteorite specialists believe that chondrules formed by flash heating, with almost instantaneous melting, though the length of time they remained molten is uncertain. Can conventional laboratory furnaces heat rock powders rapidly enough to flash melt them? Susan Maharaj and Roger Hewins (Rutgers University, New Brunswick) tested this idea by inserting tiny wires of pure elements (which have precise melting temperatures) into compressed rock powders about 3.5 mm in diameter, and placing the samples into a furnace heated to a range of temperatures. They found that at 1600 C, a sample took only six seconds to reach 1538 C. When placed into a furnace at 1500 C, samples took ten seconds to reach 1495 C. This shows that the flash heating process can be studied in conventional laboratory furnaces.

  9. Infrared heating

    Technology Transfer Automated Retrieval System (TEKTRAN)

    IR heating was first industrially used in the 1930s for automotive curing applications and rapidly became a widely applied technology in the manufacturing industry. Contrarily, a slower pace in the development of IR technologies for processing foods and agricultural products was observed, due to lim...

  10. Integration of Decentralized Thermal Storages Within District Heating (DH) Networks

    NASA Astrophysics Data System (ADS)

    Schuchardt, Georg K.

    2016-12-01

    Thermal Storages and Thermal Accumulators are an important component within District Heating (DH) systems, adding flexibility and offering additional business opportunities for these systems. Furthermore, these components have a major impact on the energy and exergy efficiency as well as the heat losses of the heat distribution system. Especially the integration of Thermal Storages within ill-conditioned parts of the overall DH system enhances the efficiency of the heat distribution. Regarding an illustrative and simplified example for a DH system, the interactions of different heat storage concepts (centralized and decentralized) and the heat losses, energy and exergy efficiencies will be examined by considering the thermal state of the heat distribution network.

  11. Exercise in the Heat: Effects of Dinitrophenol Administration,

    DTIC Science & Technology

    1987-07-26

    hyperthermic condition vs. 26.4g/min in the normothermic condition. In our experiments with the laboratory rat at 300 C, ENP treatment induced a salivary...aEwrg. Mod. In press, 1987. 19. Hubbard, R.W. W. T. Matthew, J. Lirduska, P. Curtis, W. D. Bowers, I. Leav, and M. Mager. The laboratory rat as a model

  12. Drug Education for Administrators

    ERIC Educational Resources Information Center

    Hackett, Peter; McKeon, Thomas L.

    1976-01-01

    The formulation of a drug policy and the implementation of that policy in a firm but fair manner are the responsibility of the school administrator. Authors give serious consideration to this responsibility. (Editor/RK)

  13. Food and Drug Administration

    MedlinePlus

    ... blog post. April 11, 2017 ‘Organs-on-Chips’ Technology: FDA Testing Groundbreaking Science More FDA Voice Blog ... FEAR Act Site Map Nondiscrimination Website Policies U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver ...

  14. Administrative Law Judges

    EPA Pesticide Factsheets

    The Administrative Law Judges conduct hearings and render decisions in proceedings between the EPA and persons, businesses, government entities, and other organizations which are or are alleged to be regulated under environmental laws.

  15. Needed: Nursing Administration Leaders

    ERIC Educational Resources Information Center

    Blair, Eunice M.

    1976-01-01

    A master's program that synthesizes clinical nursing knowledge with management theory and skills is one way to prepare nursing service administrators capable of exerting an influence on today's complex health care system. (Editor)

  16. The Administrator Selection Process

    ERIC Educational Resources Information Center

    Griffin, Michael F.

    1974-01-01

    Proposes that education establish for administrators systematic, rigorous, albeit subjective, selection procedures that recognize the principle of organizational democracy and the public nature of the educational enterprise. (Author/DN)

  17. Confrontation and Administrative Response

    ERIC Educational Resources Information Center

    Auerbach, Arnold J.

    1969-01-01

    Describes some of the sociological and psychological effects of organizational conflict and offers 10 operational principles to guide public administrators of schools and social agencies in meeting the confrontation tactics of activist groups. (JH)

  18. One for the Administrators

    ERIC Educational Resources Information Center

    American School and University, 1978

    1978-01-01

    Earth berms, a heavily insulated roof, and a narrow band of thermal pane windows, save energy at the administrative headquarters of the Anoka Hennepin school district in Coon Rapids, a suburb of Minneapolis, Minnesota. (Author/MLF)

  19. Goldstone (GDSCC) administrative computing

    NASA Technical Reports Server (NTRS)

    Martin, H.

    1981-01-01

    The GDSCC Data Processing Unit provides various administrative computing services for Goldstone. Those activities, including finance, manpower and station utilization, deep-space station scheduling and engineering change order (ECO) control are discussed.

  20. Bayonet heat exchangers in heat-assisted Stirling heat pump

    SciTech Connect

    Yagyu, S.; Fukuyama, Y.; Morikawa, T.; Isshiki, N.; Satoh, I.; Corey, J.; Fellows, C.

    1998-07-01

    The Multi-Temperature Heat Supply System is a research project creating a city energy system with lower environmental load. This system consists of a gas-fueled internal combustion engine and a heat-assisted Stirling heat pump utilizing shaft power and thermal power in a combination of several cylinders. The heat pump is mainly driven by engine shaft power and is partially assisted by thermal power from engine exhaust heat source. Since this heat pump is operated by proportioning the two energy sources to match the characteristics of the driving engine, the system is expected to produce cooling and heating water at high COP. This paper describes heat exchanger development in the project to develop a heat-assisted Stirling heat pump. The heat pump employs the Bayonet type heat exchangers (BHX Type I) for supplying cold and hot water and (BHX Type II) for absorbing exhaust heat from the driving engine. The heat exchanger design concepts are presented and their heat transfer and flow loss characteristics in oscillating gas flow are investigated. The main concern in the BHX Type I is an improvement of gas side heat transfer and the spirally finned tubes were applied to gas side of the heat exchanger. For the BHX Type II, internal heat transfer characteristics are the main concern. Shell-and-tube type heat exchangers are widely used in Stirling machines. However, since brazing is applied to the many tubes for their manufacturing processes, it is very difficult to change flow passages to optimize heat transfer and loss characteristics once they have been made. The challenge was to enhance heat transfer on the gas side to make a highly efficient heat exchanger with fewer parts. It is shown that the Bayonet type heat exchanger can have good performance comparable to conventional heat exchangers.

  1. Reducing home heating and cooling costs

    SciTech Connect

    Not Available

    1994-07-01

    This report is in response to a request from the House Committee on Energy and Commerce that the Energy Information Administration (EIA) undertake a neutral, unbiased analysis of the cost, safety, and health and environmental effects of the three major heating fuels: heating oil, natural gas, and electricity. The Committee also asked EIA to examine the role of conservation in the choice of heating and cooling fuel. To accommodate a wide audience, EIA decided to respond to the Committee`s request in the context of a report on reducing home heating and cooling costs. Accordingly, this report discusses ways to weatherize the home, compares the features of the three major heating and cooling fuels, and comments on the types of heating and cooling systems on the market. The report also includes a worksheet and supporting tables that will help in the selection of a heating and/or cooling system.

  2. Company Administration Study.

    DTIC Science & Technology

    1974-01-01

    iTRATION CENTER AND FORT BENJAMIN HARRISON FORT BENJAMIN HARRISON. INDIANA 46216 ATZI -XO 16 October 1973 SUBJECT: Letter of Instruction - Company...Mail, files, records management* publications, voting, etc.). ... AnnexA II ATZI -XO 18 October 1973 SUBJECT: Letter of Instruction - Company...administration as follows: A. 2 I * * " " " ’+ " " ’ ’ ’ ’’ ’ , ’" I ATZI -XO 18 October 1973 SUBJECT: Letter of Instruction - Company Administration Study tea

  3. 14 CFR 25.1326 - Pitot heat indication systems.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Pitot heat indication systems. 25.1326 Section 25.1326 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION....1326 Pitot heat indication systems. If a flight instrument pitot heating system is installed,...

  4. 14 CFR 23.1326 - Pitot heat indication systems.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Pitot heat indication systems. 23.1326 Section 23.1326 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Instruments: Installation § 23.1326 Pitot heat indication systems. If a flight instrument pitot heating...

  5. 14 CFR 25.1326 - Pitot heat indication systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Pitot heat indication systems. 25.1326 Section 25.1326 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION....1326 Pitot heat indication systems. If a flight instrument pitot heating system is installed,...

  6. 14 CFR 23.1326 - Pitot heat indication systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Pitot heat indication systems. 23.1326 Section 23.1326 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Instruments: Installation § 23.1326 Pitot heat indication systems. If a flight instrument pitot heating...

  7. Geothermal district heating systems

    NASA Astrophysics Data System (ADS)

    Budney, G. S.; Childs, F.

    1982-06-01

    Ten district heating demonstration projects and their present status are described. The projects are Klamath County YMCA, Susanville District Heating, Klamath Falls District Heating, Reno Salem Plaza Condominium, El Centro Community Center Heating/Cooling, Haakon School and Business District Heating, St. Mary's Hospital, Diamond Ring Ranch, Pagosa Springs District Heating, and Boise District Heating.

  8. Geothermal heating

    SciTech Connect

    Aureille, M.

    1982-01-01

    The aim of the study is to demonstrate the viability of geothermal heating projects in energy and economic terms and to provide nomograms from which an initial estimate may be made without having to use data-processing facilities. The effect of flow rate and temperature of the geothermal water on drilling and on the network, and the effect of climate on the type of housing are considered.

  9. Heat pump

    SciTech Connect

    Apte, A.J.

    1982-11-30

    A single working fluid heat pump system having a turbocompressor with a first fluid input for the turbine and a second fluid input for the compressor, and a single output volute or mixing chamber for combining the working fluid output flows of the turbine and the compressor. The system provides for higher efficiency than single fluid systems whose turbine and compressor are provided with separate output volutes.

  10. Collection development at the NOAA Central Library

    NASA Technical Reports Server (NTRS)

    Quillen, Steve R.

    1994-01-01

    The National Oceanic and Atmospheric Administration (NOAA) Central Library collection, approximately one million volumes, incorporates the holdings of its predecessor agencies. Within the library, the collections are filed separately, based on their source and/or classification schemes. The NOAA Central Library provides a variety of services to users, ranging from quick reference and interlibrary loan to in-depth research and online data bases.

  11. Heat pump system

    DOEpatents

    Swenson, Paul F.; Moore, Paul B.

    1982-01-01

    An air heating and cooling system for a building includes an expansion-type refrigeration circuit and a heat engine. The refrigeration circuit includes two heat exchangers, one of which is communicated with a source of indoor air from the building and the other of which is communicated with a source of air from outside the building. The heat engine includes a heat rejection circuit having a source of rejected heat and a primary heat exchanger connected to the source of rejected heat. The heat rejection circuit also includes an evaporator in heat exchange relation with the primary heat exchanger, a heat engine indoor heat exchanger, and a heat engine outdoor heat exchanger. The indoor heat exchangers are disposed in series air flow relationship, with the heat engine indoor heat exchanger being disposed downstream from the refrigeration circuit indoor heat exchanger. The outdoor heat exchangers are also disposed in series air flow relationship, with the heat engine outdoor heat exchanger disposed downstream from the refrigeration circuit outdoor heat exchanger. A common fluid is used in both of the indoor heat exchanges and in both of the outdoor heat exchangers. In a first embodiment, the heat engine is a Rankine cycle engine. In a second embodiment, the heat engine is a non-Rankine cycle engine.

  12. Heat pump system

    DOEpatents

    Swenson, Paul F.; Moore, Paul B.

    1979-01-01

    An air heating and cooling system for a building includes an expansion-type refrigeration circuit and a heat engine. The refrigeration circuit includes two heat exchangers, one of which is communicated with a source of indoor air from the building and the other of which is communicated with a source of air from outside the building. The heat engine includes a heat rejection circuit having a source of rejected heat and a primary heat exchanger connected to the source of rejected heat. The heat rejection circuit also includes an evaporator in heat exchange relation with the primary heat exchanger, a heat engine indoor heat exchanger, and a heat engine outdoor heat exchanger. The indoor heat exchangers are disposed in series air flow relationship, with the heat engine indoor heat exchanger being disposed downstream from the refrigeration circuit indoor heat exchanger. The outdoor heat exchangers are also disposed in series air flow relationship, with the heat engine outdoor heat exchanger disposed downstream from the refrigeration circuit outdoor heat exchanger. A common fluid is used in both of the indoor heat exchangers and in both of the outdoor heat exchangers. In a first embodiment, the heat engine is a Rankine cycle engine. In a second embodiment, the heat engine is a non-Rankine cycle engine.

  13. Mathematical model for calculation of the heat-hydraulic modes of heating points of heat-supplying systems

    NASA Astrophysics Data System (ADS)

    Shalaginova, Z. I.

    2016-03-01

    The mathematical model and calculation method of the thermal-hydraulic modes of heat points, based on the theory of hydraulic circuits, being developed at the Melentiev Energy Systems Institute are presented. The redundant circuit of the heat point was developed, in which all possible connecting circuits (CC) of the heat engineering equipment and the places of possible installation of control valve were inserted. It allows simulating the operating modes both at central heat points (CHP) and individual heat points (IHP). The configuration of the desired circuit is carried out automatically by removing the unnecessary links. The following circuits connecting the heating systems (HS) are considered: the dependent circuit (direct and through mixing elevator) and independent one (through the heater). The following connecting circuits of the load of hot water supply (HWS) were considered: open CC (direct water pumping from pipelines of heat networks) and a closed CC with connecting the HWS heaters on single-level (serial and parallel) and two-level (sequential and combined) circuits. The following connecting circuits of the ventilation systems (VS) were also considered: dependent circuit and independent one through a common heat exchanger with HS load. In the heat points, water temperature regulators for the hot water supply and ventilation and flow regulators for the heating system, as well as to the inlet as a whole, are possible. According to the accepted decomposition, the model of the heat point is an integral part of the overall heat-hydraulic model of the heat-supplying system having intermediate control stages (CHP and IHP), which allows to consider the operating modes of the heat networks of different levels connected with each other through CHP as well as connected through IHP of consumers with various connecting circuits of local systems of heat consumption: heating, ventilation and hot water supply. The model is implemented in the Angara data

  14. Computer hardware fault administration

    DOEpatents

    Archer, Charles J.; Megerian, Mark G.; Ratterman, Joseph D.; Smith, Brian E.

    2010-09-14

    Computer hardware fault administration carried out in a parallel computer, where the parallel computer includes a plurality of compute nodes. The compute nodes are coupled for data communications by at least two independent data communications networks, where each data communications network includes data communications links connected to the compute nodes. Typical embodiments carry out hardware fault administration by identifying a location of a defective link in the first data communications network of the parallel computer and routing communications data around the defective link through the second data communications network of the parallel computer.

  15. Hydride heat pump with heat regenerator

    NASA Technical Reports Server (NTRS)

    Jones, Jack A. (Inventor)

    1991-01-01

    A regenerative hydride heat pump process and system is provided which can regenerate a high percentage of the sensible heat of the system. A series of at least four canisters containing a lower temperature performing hydride and a series of at least four canisters containing a higher temperature performing hydride is provided. Each canister contains a heat conductive passageway through which a heat transfer fluid is circulated so that sensible heat is regenerated. The process and system are useful for air conditioning rooms, providing room heat in the winter or for hot water heating throughout the year, and, in general, for pumping heat from a lower temperature to a higher temperature.

  16. Heating systems for heating subsurface formations

    SciTech Connect

    Nguyen, Scott Vinh; Vinegar, Harold J.

    2011-04-26

    Methods and systems for heating a subsurface formation are described herein. A heating system for a subsurface formation includes a sealed conduit positioned in an opening in the formation and a heat source. The sealed conduit includes a heat transfer fluid. The heat source provides heat to a portion of the sealed conduit to change phase of the heat transfer fluid from a liquid to a vapor. The vapor in the sealed conduit rises in the sealed conduit, condenses to transfer heat to the formation and returns to the conduit portion as a liquid.

  17. 3. INTERIOR, CENTRAL BOILER ROOM, FROM MEZZANINE DECK NEAR TOP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. INTERIOR, CENTRAL BOILER ROOM, FROM MEZZANINE DECK NEAR TOP OF STAIRWAY, LOOKING NORTH-NORTHEAST. - Oakland Naval Supply Center, Heating Plant, North of B Street & West of Third Street, Oakland, Alameda County, CA

  18. 4. INTERIOR, CENTRAL BOILER ROOM, LOWER LEVEL, BOILERS, FROM SOUTHWEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. INTERIOR, CENTRAL BOILER ROOM, LOWER LEVEL, BOILERS, FROM SOUTHWEST CORNER OF ROOM, LOOKING SOUTHEAST. - Oakland Naval Supply Center, Heating Plant, North of B Street & West of Third Street, Oakland, Alameda County, CA

  19. JPRS report: Science and technology. Central Eurasia: Materials science

    NASA Astrophysics Data System (ADS)

    1992-03-01

    A bibliography is given of Central Eurasian research in materials science. Topics covered include analysis and testing; corrosion resistance; ferrous metals; nonferrous alloys, brazes, and solders; heat treatment; welding, brazing, and soldering; and extractive metallurgy.

  20. Central solar-energy receiver

    DOEpatents

    Not Available

    1981-10-27

    An improved tower-mounted central solar energy receiver for heating air drawn through the receiver by an induced draft fan is described. A number of vertically oriented, energy absorbing, fin-shaped slats are radially arranged in a number of concentric cylindrical arrays on top of the tower coaxially surrounding a pipe having air holes through which the fan draws air which is heated by the slats which receive the solar radiation from a heliostat field. A number of vertically oriented and wedge-shaped columns are radially arranged in a number of concentric cylindrical clusters surrounding the slat arrays. The columns have two mirror-reflecting sides to reflect radiation into the slat arrays and one energy absorbing side to reduce reradiation and reflection from the slat arrays.

  1. Heat exchanger

    DOEpatents

    Brackenbury, Phillip J.

    1986-04-01

    A heat exchanger comparising a shell attached at its open end to one side of a tube sheet and a detachable head connected to the other side of said tube sheet. The head is divided into a first and second chamber in fluid communication with a nozzle inlet and nozzle outlet, respectively, formed in said tube sheet. A tube bundle is mounted within said shell and is provided with inlets and outlets formed in said tube sheet in communication with said first and second chambers, respectively.

  2. Regenerative Hydride Heat Pump

    NASA Technical Reports Server (NTRS)

    Jones, Jack A.

    1992-01-01

    Hydride heat pump features regenerative heating and single circulation loop. Counterflow heat exchangers accommodate different temperatures of FeTi and LaNi4.7Al0.3 subloops. Heating scheme increases efficiency.

  3. Administrative Utility Analysis: Appendices.

    ERIC Educational Resources Information Center

    Peat, Marwick, Mitchell and Co., San Juan, Puerto Rico.

    Appendixes to a study on administrative utility analysis and vocational education programs for the Area of Vocational and Technical Education (AVTE) in the Puerto Rico Department of Education contain the planning and budgeting system elements, position descriptions, and information on the growth of vocational education in Puerto Rico. The elements…

  4. Administrative Sides of Librarying.

    ERIC Educational Resources Information Center

    Lott, Carolyn

    2003-01-01

    Discusses how the author used administrative skills learned as a school library media specialist to meet the demands of a university department chair. Topics include the influence of decisions that are made; budgeting; evaluation concerns and responsibilities; determining guidelines and goals; political concerns; and the flow of information. (LRW)

  5. The Administration of Admissions

    ERIC Educational Resources Information Center

    Campbell, Clifford C.

    1978-01-01

    Among all the tasks of the admissions officer in developing a successful marketing program, the hardest may be that of convincing other college administrators of the importance of admissions to the institution's survival. Discussed are long-range planning, budgeting, staff selection and training, and implementing a plan. (Author/LBH)

  6. Administrators Confront Student "Sexting"

    ERIC Educational Resources Information Center

    Manzo, Kathleen Kennedy

    2009-01-01

    Cellphone-savvy students have created instructional and disciplinary challenges for educators for years. But the recent emergence of "sexting" by adolescents over their mobile phones caught many school administrators off guard, and the practice is prompting efforts around the country to craft policy responses. Students' sharing of nude or…

  7. IVA: Improving Vocational Administration.

    ERIC Educational Resources Information Center

    EPD Consortium D, Richardson, TX.

    These six instructional units are intended to provide instructors of vocational education administration with a systematic package of materials for their programs of preservice and/or inservice instruction and to provide materials which could be reproduced for learner use. These units cover the following subject matter: (1) federal legislation…

  8. Migrant Education Administrative Handbook.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge. Bureau of Migrant Education.

    Intended to provide information pertaining to the administration of migrant education projects in Louisiana, the handbook is divided into two sections: basic guidelines for program operations and support services--nursing. Section I covers the Federal and State migrant program, local migrant projects, project personnel and staff development, and…

  9. Educational Administration's Weber.

    ERIC Educational Resources Information Center

    Gronn, Peter

    1994-01-01

    Discusses Max Weber's importance in Greenfield's work, particularly in Greenfield and Ribbins'"Greenfield on Educational Administration" (1993). In concentrating on human actors' subjective understanding, Greenfield was a faithful Weberian. However, he deviated from Weber by disavowing structural explanations of social and organizational…

  10. The Administrative Internship.

    ERIC Educational Resources Information Center

    Adkison, Judith A., Ed.; Warren, Andrea, Ed.

    This monograph was developed as part of the project known as Internships, Certification, Equity-Leadership, and Support (ICES). The Kansas project successfully field-tested a model for mobilizing statewide resources to prepare women for administrative careers and to place them in appropriate positions. The crucial component of the training program…

  11. Standards and Administration.

    ERIC Educational Resources Information Center

    Gross, S. P.

    1978-01-01

    Presents a literature review of water quality standards and administration, covering publications of 1976-77. Consideration is given to municipal facilities, National Pollutant Discharge Elimination Systems, regional and international water quality management, and effluent standards. A list of 99 references is also presented. (HM)

  12. Championing the Latino Administrator

    ERIC Educational Resources Information Center

    Garcia, Carlos A.

    2011-01-01

    When the author worked as a vice principal at a K-8 school in Watsonville, California, a school predominantly filled with migrant workers' children, he felt a lack of support as a Latino as he began moving up into school administration. He also continued to see what he had seen as a teacher--which was how underserved minority students were. These…

  13. Redis database administration tool

    SciTech Connect

    Martinez, J. J.

    2013-02-13

    MyRedis is a product of the Lorenz subproject under the ASC Scirntific Data Management effort. MyRedis is a web based utility designed to allow easy administration of instances of Redis databases. It can be usedd to view and manipulate data as well as run commands directly against a variety of different Redis hosts.

  14. Administrative Uses of Microcomputers.

    ERIC Educational Resources Information Center

    Crawford, Chase

    1987-01-01

    This paper examines the administrative uses of the microcomputer, stating that high performance educational managers are likely to have microcomputers in their organizations. Four situations that would justify the use of a computer are: (1) when massive amounts of data are processed through well-defined operations; (2) when data processing is…

  15. Educator Effectiveness Administrative Manual

    ERIC Educational Resources Information Center

    Pennsylvania Department of Education, 2014

    2014-01-01

    The goal of this manual is to provide guidance in the evaluation of educators, highlight critical components of effectiveness training, and offer opportunities for professional growth. The term "educator" includes teachers, all professional and temporary professional employees, education specialists, and school administrators/principals.…

  16. Discretionary Grants Administration Manual.

    ERIC Educational Resources Information Center

    Office of Human Development Services (DHHS), Washington, DC.

    This manual sets forth applicable administrative policies and procedures to recipients of discretionary project grants or cooperative agreements awarded by program offices in the Office of Human Development Services (HDS). It is intended to serve as a basic reference for project directors and business officers of recipient organizations who are…

  17. [Rural School Administrator's Resources.

    ERIC Educational Resources Information Center

    AEL, Inc., Charleston, WV.

    This packet contains resources on five topics relevant to rural school administrators. "Assessing Parent Involvement: A Checklist for Rural Schools": discusses educator beliefs that support successful parent engagement programs, challenges and advantages of rural schools attempting to involve parents and community, and aspects of…

  18. Standards for Administrators.

    ERIC Educational Resources Information Center

    Lashway, Larry

    1998-01-01

    This newsletter reviews five reports that address the implications of standards for administrators. These texts include "Designing and Implementing Standards-Based Accountability System" (Education Commission of the States), which describes some of the policy implications of standards-driven accountability; "Why Principals Fail: Are National…

  19. Heat loss factor for linear solar concentrators

    NASA Astrophysics Data System (ADS)

    Mullick, S. C.; Nanda, S. K.

    1982-05-01

    Numerical techniques are developed for calculating the heat loss factor through the glass cover of a cylindrical solar concentrator. The configuration considered was a steel tube suspended in the central space of a concentric glass tube. Heat transfer coefficients were determined for both the radiative heat between the tube and the glass and the convective heat transfer within the medium between the steel and the glass. The sum of the two coefficients is treated as the total heat transferred to the outside air by forced or mixed convection. Correlations of the outside to inside heat transfer resistances ratio to the wind velocity, the absorber temperature, the emittance of black paint, etc. were formulated. The results are noted to be applicable to flat plate collectors and useful for manufacturers of solar equipment.

  20. Advanced Contract Administration. First Week

    DTIC Science & Technology

    1988-04-14

    administration. Keywords: Contracting/administrative contracting officer relations Financial management; Production management , Quality assurance; Subcontracting; Claims; Government property; Ethics data sources and modifications.

  1. Heat waves and urban heat islands in Europe: A review of relevant drivers.

    PubMed

    Ward, Kathrin; Lauf, Steffen; Kleinschmit, Birgit; Endlicher, Wilfried

    2016-11-01

    The climate change and the proceeding urbanization create future health challenges. Consequently, more people around the globe will be impaired by extreme weather events, such as heat waves. This study investigates the causes for the emergence of surface urban heat islands and its change during heat waves in 70 European cities. A newly created climate class indicator, a set of meaningful landscape metrics, and two population-related parameters were applied to describe the Surface Urban Heat Island Magnitude (SUHIM) - the mean temperature increase within the urban heat island compared to its surrounding, as well as the Heat Magnitude (HM) - the extra heat load added to the average summer SUHIM during heat waves. We evaluated the relevance of varying urban parameters within linear models. The exemplary European-wide heat wave in July 2006 was chosen and compared to the average summer conditions using MODIS land surface temperature with an improved spatial resolution of 250m. The results revealed that the initial size of the urban heat island had significant influence on SUHIM. For the explanation of HM the size of the heat island, the regional climate and the share of central urban green spaces showed to be critical. Interestingly, cities of cooler climates and cities with higher shares of urban green spaces were more affected by additional heat during heat waves. Accordingly, cooler northern European cities seem to be more vulnerable to heat waves, whereas southern European cities appear to be better adapted. Within the ascertained population and climate clusters more detailed explanations were found. Our findings improve the understanding of the urban heat island effect across European cities and its behavior under heat waves. Also, they provide some indications for urban planners on case-specific adaptation strategies to adverse urban heat caused by heat waves.

  2. Perioperative thermoregulation and heat balance.

    PubMed

    Sessler, Daniel I

    2016-06-25

    Core body temperature is normally tightly regulated to within a few tenths of a degree. The major thermoregulatory defences in humans are sweating, arteriovenous shunt vasoconstriction, and shivering. The core temperature triggering each response defines its activation threshold. General anaesthetics greatly impair thermoregulation, synchronously reducing the thresholds for vasoconstriction and shivering. Neuraxial anaesthesia also impairs central thermoregulatory control, and prevents vasoconstriction and shivering in blocked areas. Consequently, unwarmed anaesthetised patients become hypothermic, typically by 1-2°C. Hypothermia results initially from an internal redistribution of body heat from the core to the periphery, followed by heat loss exceeding metabolic heat production. Complications of perioperative hypothermia include coagulopathy and increased transfusion requirement, surgical site infection, delayed drug metabolism, prolonged recovery, shivering, and thermal discomfort. Body temperature can be reliably measured in the oesophagus, nasopharynx, mouth, and bladder. The standard-of-care is to monitor core temperature and to maintain normothermia during general and neuraxial anaesthesia.

  3. Heat pipe methanator

    DOEpatents

    Ranken, William A.; Kemme, Joseph E.

    1976-07-27

    A heat pipe methanator for converting coal gas to methane. Gravity return heat pipes are employed to remove the heat of reaction from the methanation promoting catalyst, transmitting a portion of this heat to an incoming gas pre-heat section and delivering the remainder to a steam generating heat exchanger.

  4. SUBMILLIMETER ARRAY/PLATEAU DE BURE INTERFEROMETER MULTIPLE LINE OBSERVATIONS OF THE NEARBY SEYFERT 2 GALAXY NGC 1068: SHOCK-RELATED GAS KINEMATICS AND HEATING IN THE CENTRAL 100 pc?

    SciTech Connect

    Krips, M.; Neri, R.; Martin, S. E-mail: neri@iram.fr

    2011-07-20

    We present high angular resolution (0.''5-2.''0) observations of the millimeter continuum and the {sup 12}CO(J = 3-2), {sup 13}CO(J = 3-2), {sup 13}CO(J = 2-1), C{sup 18}O(J = 2-1), HCN(J = 3-2), HCO{sup +}(J = 4-3), and HCO{sup +}(J = 3-2) line emission in the circumnuclear disk (r {approx}< 100 pc) of the prototypical Seyfert 2 galaxy NGC 1068, carried out with the Submillimeter Array. We also include in our analysis new {sup 13}CO(J = 1-0) and improved {sup 12}CO(J = 2-1) observations of NGC 1068 at high angular resolution (1.''0-2.''0) and sensitivity, conducted with the Institute de Radioastronomie Millimetrique Plateau de Bure Interferometer. Based on the complex dynamics of the molecular gas emission indicating non-circular motions in the central {approx}100 pc, we propose a scenario in which part of the molecular gas in the circumnuclear disk of NGC 1068 is blown radially outward as a result of shocks. This shock scenario is further supported by quite warm (T{sub kin} {>=} 200 K) and dense (n(H{sub 2}) {approx_equal} 10{sup 4} cm{sup -3}) gas constrained from observed molecular line ratios. The HCN abundance in the circumnuclear disk is found to be [HCN]/[{sup 12}CO] {approx} 10{sup -3.5}. This is slightly higher than the abundances derived for Galactic and extragalactic star-forming/starbursting regions. This result lends further support to X-ray-enhanced HCN formation in the circumnuclear disk of NGC 1068 as suggested by earlier studies. The HCO{sup +} abundance ([HCO{sup +}]/[{sup 12}CO] {approx} 10{sup -5}) appears to be somewhat lower than that of Galactic and extragalactic star-forming/starbursting regions. When trying to fit the centimeter-to-millimeter continuum emission by different thermal and non-thermal processes, it appears that electron-scattered synchrotron emission yields the best results while thermal free-free emission seems to overpredict the millimeter continuum emission.

  5. Latent Heat in Soil Heat Flux Measurements

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The surface energy balance includes a term for soil heat flux. Soil heat flux is difficult to measure because it includes conduction and convection heat transfer processes. Accurate representation of soil heat flux is an important consideration in many modeling and measurement applications. Yet, the...

  6. Segmented heat exchanger

    DOEpatents

    Baldwin, Darryl Dean; Willi, Martin Leo; Fiveland, Scott Byron; Timmons, Kristine Ann

    2010-12-14

    A segmented heat exchanger system for transferring heat energy from an exhaust fluid to a working fluid. The heat exchanger system may include a first heat exchanger for receiving incoming working fluid and the exhaust fluid. The working fluid and exhaust fluid may travel through at least a portion of the first heat exchanger in a parallel flow configuration. In addition, the heat exchanger system may include a second heat exchanger for receiving working fluid from the first heat exchanger and exhaust fluid from a third heat exchanger. The working fluid and exhaust fluid may travel through at least a portion of the second heat exchanger in a counter flow configuration. Furthermore, the heat exchanger system may include a third heat exchanger for receiving working fluid from the second heat exchanger and exhaust fluid from the first heat exchanger. The working fluid and exhaust fluid may travel through at least a portion of the third heat exchanger in a parallel flow configuration.

  7. Dual source heat pump

    DOEpatents

    Ecker, Amir L.; Pietsch, Joseph A.

    1982-01-01

    What is disclosed is a heat pump apparatus for conditioning a fluid characterized by a fluid handler and path for circulating the fluid in heat exchange relationship with a refrigerant fluid; at least two refrigerant heat exchangers, one for effecting heat exchange with the fluid and a second for effecting heat exchange between refrigerant and a heat exchange fluid and the ambient air; a compressor for efficiently compressing the refrigerant; at least one throttling valve for throttling liquid refrigerant; a refrigerant circuit; refrigerant; a source of heat exchange fluid; heat exchange fluid circulating device and heat exchange fluid circuit for circulating the heat exchange fluid in heat exchange relationship with the refrigerant; and valves or switches for selecting the heat exchangers and direction of flow of the refrigerant therethrough for selecting a particular mode of operation. The heat exchange fluid provides energy for defrosting the second heat exchanger when operating in the air source mode and also provides a alternate source of heat.

  8. Heat recovery method

    SciTech Connect

    Richarts, F.

    1985-04-16

    Heat is recovered by combining a heat transfer system including heat exchangers interconnected in a circulatory system, with a heat pump system. The heat pump system is preferably operated in accordance with the Lorenz-Principle. It is not necessary to divide the heat carrier circuit of the heat pump into two or three separate circulatory circuits. The heat carrier circuit of the heat pump can thus continue to operate unchanged even if the heat pump is switched off. For this purpose the warm heat carrier coming from a discharge fluid cooler, is heated further in a condenser of the heat pump and the cold heat carrier coming from a preheater or cooler group, is cooled further in an evaporator of the heat pump.

  9. Heat pipe heat transport system for the Stirling Space Power Converter (SSPC)

    NASA Technical Reports Server (NTRS)

    Alger, Donald L.

    1992-01-01

    Life issues relating to a sodium heat pipe heat transport system are described. The heat pipe system provides heat, at a temperature of 1050 K, to a 50 kWe Stirling engine/linear alternator power converter called the Stirling Space Power Converter (SSPC). The converter is being developed under a National Aeronautics and Space Administration program. Since corrosion of heat pipe materials in contact with sodium can impact the life of the heat pipe, a literature review of sodium corrosion processes was performed. It was found that the impurity reactions, primarily oxygen, and dissolution of alloy elements were the two corrosion process likely to be operative in the heat pipe. Approaches that are being taken to minimize these corrosion processes are discussed.

  10. Human Cardiovascular Responses to Passive Heat Stress

    PubMed Central

    Crandall, Craig G.; Wilson, Thad E.

    2016-01-01

    Heat stress increases human morbidity and mortality compared to normothermic conditions. Many occupations, disease states, as well as stages of life are especially vulnerable to the stress imposed on the cardiovascular system during exposure to hot ambient conditions. This review focuses on the cardiovascular responses to heat stress that are necessary for heat dissipation. To accomplish this regulatory feat requires complex autonomic nervous system control of the heart and various vascular beds. For example, during heat stress cardiac output increases up to twofold, by increases in heart rate and an active maintenance of stroke volume via increases in inotropy in the presence of decreases in cardiac preload. Baroreflexes retain the ability to regulate blood pressure in many, but not all, heat stress conditions. Central hypovolemia is another cardiovascular challenge brought about by heat stress, which if added to a subsequent central volumetric stress, such as hemorrhage, can be problematic and potentially dangerous, as syncope and cardiovascular collapse may ensue. These combined stresses can compromise blood flow and oxygenation to important tissues such as the brain. It is notable that this compromised condition can occur at cardiac outputs that are adequate during normothermic conditions but are inadequate in heat because of the increased systemic vascular conductance associated with cutaneous vasodilation. Understanding the mechanisms within this complex regulatory system will allow for the development of treatment recommendations and countermeasures to reduce risks during the ever-increasing frequency of severe heat events that are predicted to occur. PMID:25589263

  11. Space shuttle heat pipe thermal control systems

    NASA Technical Reports Server (NTRS)

    Alario, J.

    1973-01-01

    Heat pipe (HP) thermal control systems designed for possible space shuttle applications were built and tested under this program. They are: (1) a HP augmented cold rail, (2) a HP/phase change material (PCM) modular heat sink and (3) a HP radiating panel for compartment temperature control. The HP augmented cold rail is similar to a standard two-passage fluid cold rail except that it contains an integral, centrally located HP throughout its length. The central HP core helps to increase the local power density capability by spreading concentrated heat inputs over the entire rail. The HP/PCM modular heat sink system consists of a diode HP connected in series to a standard HP that has a PCM canister attached to its mid-section. It is designed to connect a heat source to a structural heat sink during normal operation, and to automatically decouple from it and sink to the PCM whenever structural temperatures are too high. The HP radiating panel is designed to conductively couple the panel feeder HPs directly to a fluid line that serves as a source of waste heat. It is a simple strap-on type of system that requires no internal or external line modifications to distribute the heat to a large radiating area.

  12. Classifications of central solar domestic hot water systems

    NASA Astrophysics Data System (ADS)

    Guo, J. Y.; Hao, B.; Peng, C.; Wang, S. S.

    2016-08-01

    Currently, there are many means by which to classify solar domestic hot water systems, which are often categorized according to their scope of supply, solar collector positions, and type of heat storage tank. However, the lack of systematic and scientific classification as well as the general disregard of the thermal performance of the auxiliary heat source is important to DHW systems. Thus, the primary focus of this paper is to determine a classification system for solar domestic hot water systems based on the positions of the solar collector and auxiliary heating device, both respectively and in combination. Field-testing data regarding many central solar DHW systems demonstrates that the position of the auxiliary heat source clearly reflects the operational energy consumption. The consumption of collective auxiliary heating hot water system is much higher than individual auxiliary heating hot water system. In addition, costs are significantly reduced by the separation of the heat storage tank and the auxiliary heating device.

  13. 75 FR 34171 - Trueheat, Inc., a Subsidiary of Global Heating Solutions, Inc., Currently Known as Truheat, a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... Employment and Training Administration Trueheat, Inc., a Subsidiary of Global Heating Solutions, Inc... Global Heating Solutions, Inc., Currently Known as Truheat, a Division of Three Heat LLC, Allegan, MI..., applicable to workers of TrueHeat, Inc., a subsidiary of Global Heating Solutions, Inc., Allegan,...

  14. Bonneville, Power Administration Timing System

    NASA Technical Reports Server (NTRS)

    Martin, Kenneth E.

    1996-01-01

    Time is an integral part of the Bonneville Power Administration's (BPA) operational systems. Generation and power transfers are planned in advance. Utilities coordinate with each other by making these adjustments on a timed schedule. Price varies with demand, so billing is based on time. Outages for maintenance are scheduled to assure they do not interrupt reliable power delivery. Disturbance records are aligned with recorded timetags for analysis and comparison with related information. Advanced applications like traveling wave fault location and real-time phase measurement require continuous timing with high precision. Most of BPA is served by a Central Time System (CTS) at the Dittmer Control Center near Portland, OR. This system keeps time locally and supplies time to both the control center systems and field locations via a microwave signal. It is kept synchronized to national standard time and coordinated with interconnected utilities. It is the official BPA time. Powwer system control and operation is described, followed by a description of BPA timing systems including CTS, the Fault Location Acquisition Reporter, time dissemination, and phasor measurements. References are provided for further reading.

  15. Sensible and latent heating of the atmosphere as inferred from DST-6 data

    NASA Technical Reports Server (NTRS)

    Herman, G. F.; Schubert, S. D.; Johnson, W. T.

    1979-01-01

    The average distribution of convective latent heating, boundary layer sensible heat flux, and vertical velocity are determined for the winter 1976 DST period from GLAS model diagnostics. Key features are the regions of intense latent heating over Brazil, Central Africa, and Indonesia; and the regions of strong sensible heating due to air mass modification over the North Atlantic and North Pacific Oceans.

  16. Recovery Act - Geothermal Technologies Program: Ground Source Heat Pumps Final Scientific/Technical Report

    SciTech Connect

    Nick Rosenberry, Harris Companies

    2012-05-04

    A large centralized geothermal heat pump system was installed to provide ice making, space cooling, space heating, process water heating, and domestic hot water heating for an ice arena in Eagan Minnesota. This paper provides information related to the design and construction of the project. Additionally, operating conditions for 12 months after start-up are provided.

  17. Nonazeotropic Heat Pump

    NASA Technical Reports Server (NTRS)

    Ealker, David H.; Deming, Glenn

    1991-01-01

    Heat pump collects heat from water circulating in heat-rejection loop, raises temperature of collected heat, and transfers collected heat to water in separate pipe. Includes sealed motor/compressor with cooling coils, evaporator, and condenser, all mounted in outer housing. Gradients of temperature in evaporator and condenser increase heat-transfer efficiency of vapor-compression cycle. Intended to recover relatively-low-temperature waste heat and use it to make hot water.

  18. High heat flux single phase heat exchanger

    NASA Technical Reports Server (NTRS)

    Valenzuela, Javier A.; Izenson, Michael G.

    1990-01-01

    This paper presents the results obtained to date in a program to develop a high heat flux, single-phase heat exchanger for spacecraft thermal management. The intended application is a net generation interface heat exchanger to couple the crew module water thermal bus to the two-phase ammonia main thermal bus in the Space Station Freedom. The large size of the interface heat exchanger is dictated by the relatively poor water-side heat transfer characteristics. The objective of this program is to develop a single-phase heat transfer approach which can achieve heat fluxes and heat transfer coefficients comparable to those of the evaporation ammonia side. A new heat exchanger concept has been developed to meet these objecties. The main feature of this heat exchanger is that it can achieve very high heat fluxes with a pressure drop one to two orders of magnitude lower than those of previous microchannel or jet impingement high heat flux heat exchangers. This paper describes proof-of-concept experiments performed in air and water and presents analytical model of the heat exchanger.

  19. Multiple source heat pump

    DOEpatents

    Ecker, Amir L.

    1983-01-01

    A heat pump apparatus for conditioning a fluid characterized by a fluid handler and path for circulating a fluid in heat exchange relationship with a refrigerant fluid, at least three refrigerant heat exchangers, one for effecting heat exchange with the fluid, a second for effecting heat exchange with a heat exchange fluid, and a third for effecting heat exchange with ambient air; a compressor for compressing the refrigerant; at least one throttling valve connected at the inlet side of a heat exchanger in which liquid refrigerant is vaporized; a refrigerant circuit; refrigerant; a source of heat exchange fluid; heat exchange fluid circuit and pump for circulating the heat exchange fluid in heat exchange relationship with the refrigerant; and valves or switches for selecting the heat exchangers and directional flow of refrigerant therethrough for selecting a particular mode of operation. Also disclosed are a variety of embodiments, modes of operation, and schematics therefor.

  20. Central neural pathways for thermoregulation

    PubMed Central

    Morrison, Shaun F.; Nakamura, Kazuhiro

    2010-01-01

    Central neural circuits orchestrate a homeostatic repertoire to maintain body temperature during environmental temperature challenges and to alter body temperature during the inflammatory response. This review summarizes the functional organization of the neural pathways through which cutaneous thermal receptors alter thermoregulatory effectors: the cutaneous circulation for heat loss, the brown adipose tissue, skeletal muscle and heart for thermogenesis and species-dependent mechanisms (sweating, panting and saliva spreading) for evaporative heat loss. These effectors are regulated by parallel but distinct, effector-specific neural pathways that share a common peripheral thermal sensory input. The thermal afferent circuits include cutaneous thermal receptors, spinal dorsal horn neurons and lateral parabrachial nucleus neurons projecting to the preoptic area to influence warm-sensitive, inhibitory output neurons which control thermogenesis-promoting neurons in the dorsomedial hypothalamus that project to premotor neurons in the rostral ventromedial medulla, including the raphe pallidus, that descend to provide the excitation necessary to drive thermogenic thermal effectors. A distinct population of warm-sensitive preoptic neurons controls heat loss through an inhibitory input to raphe pallidus neurons controlling cutaneous vasoconstriction. PMID:21196160

  1. Heat pipe technology

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A bibliography of heat pipe technology to provide a summary of research projects conducted on heat pipes is presented. The subjects duscussed are: (1) heat pipe applications, (2) heat pipe theory, (3) design and fabrication, (4) testing and operation, (5) subject and author index, and (6) heat pipe related patents.

  2. Heat powered refrigeration compressor

    NASA Astrophysics Data System (ADS)

    Goad, R. R.

    This prototype will be of similar capacity as the compressor that will eventually be commercially produced. This unit can operate on almost any moderate temperature water heat source. This heat source could include such applications as industrial waste heat, solar, wood burning stove, resistance electrical heat produced by a windmill, or even perhaps heat put out by the condenser of another refrigeration system.

  3. 13 CFR 120.1710 - Central servicing of the Program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Central servicing of the Program. 120.1710 Section 120.1710 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS... its role as Central Servicing Agent for the Pool, at Pool formation, CSA issues a Seller Receipt...

  4. 12 CFR 741.210 - Central liquidity facility.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Central liquidity facility. 741.210 Section 741.210 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS... Unions That Also Apply to Federally Insured State-Chartered Credit Unions § 741.210 Central...

  5. Direct expansion solar collector and heat pump

    NASA Astrophysics Data System (ADS)

    1982-05-01

    A hybrid heat pump/solar collector combination in which solar collectors replace the outside air heat exchanger found in conventional air-to-air heat pump systems is discussed. The solar panels ordinarily operate at or below ambient temperature, eliminating the need to install the collector panels in a glazed and insulated enclosure. The collectors simply consist of a flat plate with a centrally located tube running longitudinally. Solar energy absorbed by exposed panels directly vaporizes the refrigerant fluid. The resulting vapor is compressed to higher temperature and pressure; then, it is condensed to release the heat absorbed during the vaporization process. Control and monitoring of the demonstration system are addressed, and the tests conducted with the demonstration system are described. The entire heat pump system is modelled, including predicted performance and costs, and economic comparisons are made with conventional flat-plate collector systems.

  6. Heat Rash (Prickly Heat or Miliaria)

    MedlinePlus

    ... humid weather. Heat rash develops when blocked pores (sweat ducts) trap perspiration under your skin. Symptoms range ... symptoms is to cool your skin and prevent sweating. Adults usually develop heat rash in skin folds ...

  7. Centralize Printing, and Save.

    ERIC Educational Resources Information Center

    McCormick, Kathleen

    1984-01-01

    Describes the operations of a centralized printing office in a California school district. Centralization greatly increased the efficiency and lowered the cost of generating publications, information services, newsletters, and press releases throughout the school year. (TE)

  8. Central Neuropathic Pain Syndromes.

    PubMed

    Watson, James C; Sandroni, Paola

    2016-03-01

    Chronic pain is common in patients with neurologic complications of a central nervous system insult such as stroke. The pain is most commonly musculoskeletal or related to obligatory overuse of neurologically unaffected limbs. However, neuropathic pain can result directly from the central nervous system injury. Impaired sensory discrimination can make it challenging to differentiate central neuropathic pain from other pain types or spasticity. Central neuropathic pain may also begin months to years after the injury, further obscuring recognition of its association with a past neurologic injury. This review focuses on unique clinical features that help distinguish central neuropathic pain. The most common clinical central pain syndromes-central poststroke pain, multiple sclerosis-related pain, and spinal cord injury-related pain-are reviewed in detail. Recent progress in understanding of the pathogenesis of central neuropathic pain is reviewed, and pharmacological, surgical, and neuromodulatory treatments of this notoriously difficult to treat pain syndrome are discussed.

  9. New Developments in Auxiliary Heating

    NASA Astrophysics Data System (ADS)

    Norreys, Peter

    2016-10-01

    The role of heating arising from the propagation of orthogonal petawatt-laser driven relativistic electron beams in dense plasma will be discussed. The energy cascade mechanism begins first with the rapid growth at 45 degrees to the two beams of electrostatic waves near the electron plasma frequency. These waves reach high amplitudes and break, which then results in the generation of a strongly driven turbulent Langmuir spectrum. Parametric decay of these waves, particularly via the modulational instability, then gives rise to a coupled turbulent ion acoustic spectrum. The resulting waves also give rise to ion heating through collisions via equilibration of both electrons and ions. In this talk, I will present the most recent analytic modelling, and particle-in-cell / Vlasov-Poisson simulation results from my team within Oxford Physics and the Central Laser Facility that explores the optimum parameter space for this process, focusing in particular on the requirements for auxiliary heating of the central hot spot in inertial confinement fusion target experiments. I will also describe new methods for hole-boring through the coronal plasma surrounding the fuel using strongly relativistic laser beams that demonstrates the strong suppression of the hosing instability under these conditions. Proof-of-concept experiments are under design for the Orion and OMEGA EP facilities.

  10. Central and peripheral demyelination

    PubMed Central

    Mehndiratta, Man Mohan; Gulati, Natasha Singh

    2014-01-01

    Several conditions cause damage to the inherently normal myelin of central nervous system, perepheral nervous system or both central and perepheral nervous system and hence termed as central demyelinating diseases, perepheral demyelinating diseases and combined central and perepheral demyelinating diseases respectively. Here we analysed and foccused on the etiology, prevalance, incidence and age of these demyelinating disorders. Clinical attention and various diagnostic tests are needed to adequately assess all these possibilities. PMID:24741263

  11. Absorption heat pump system

    DOEpatents

    Grossman, G.

    1982-06-16

    The efficiency of an absorption heat pump system is improved by conducting liquid from a second stage evaporator thereof to an auxiliary heat exchanger positioned downstream of a primary heat exchanger in the desorber of the system.

  12. Extreme Heat Guidebook

    EPA Pesticide Factsheets

    The 'Climate Change and Extreme Heat: What You Can Do to Prepare' handbook explains the connection between climate change and extreme heat events, and outlines actions citizens can take to protect their health during extreme heat.

  13. Heat Wave Safety Checklist

    MedlinePlus

    ... heat has caused more deaths than all other weather events, including floods. A heat wave is a ... care for heat- related emergencies … ❏ Listen to local weather forecasts and stay aware of upcoming temperature changes. ❏ ...

  14. Absorption heat pump system

    DOEpatents

    Grossman, Gershon

    1984-01-01

    The efficiency of an absorption heat pump system is improved by conducting liquid from a second stage evaporator thereof to an auxiliary heat exchanger positioned downstream of a primary heat exchanger in the desorber of the system.

  15. The Battle over Homework. An Administrator's Guide to Setting Sound and Effective Policies. The Practicing Administrator's Leadership Series.

    ERIC Educational Resources Information Center

    Cooper, Harris

    For many years, homework has been a topic of heated public discussion and concern of students, parents, teachers, and administrators. Perhaps the most crucial question regards its efficacy for improving academic achievement. This book combines the results of research studies and exemplary practices to provide guidance about homework to…

  16. Mass drug administration for malaria

    PubMed Central

    Poirot, Eugenie; Skarbinski, Jacek; Sinclair, David; Kachur, S Patrick; Slutsker, Laurence; Hwang, Jimee

    2013-01-01

    Background Mass drug administration (MDA), defined as the empiric administration of a therapeutic antimalarial regimen to an entire population at the same time, has been a historic component of many malaria control and elimination programmes, but is not currently recommended. With renewed interest in MDA and its role in malaria elimination, this review aims to summarize the findings from existing research studies and program experiences of MDA strategies for reducing malaria burden and transmission. Objectives To assess the impact of antimalarial MDA on population asexual parasitaemia prevalence, parasitaemia incidence, gametocytaemia prevalence, anaemia prevalence, mortality and MDA-associated adverse events. Search methods We searched the Cochrane Infectious Disease Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE+, EMBASE, to February 2013. We also searched CABS Abstracts, LILACS, reference lists, and recent conference proceedings. Selection criteria Cluster-randomized trials and non-randomized controlled studies comparing therapeutic MDA versus placebo or no MDA, and uncontrolled before-and-after studies comparing post-MDA to baseline data were selected. Studies administering intermittent preventive treatment (IPT) to sub-populations (for example, pregnant women, children or infants) were excluded. Data collection and analysis Two authors independently reviewed studies for inclusion, extracted data and assessed risk of bias. Studies were stratified by study design and then subgrouped by endemicity, by co-administration of 8-aminoquinoline plus schizonticide drugs and by plasmodium species. The quality of evidence was assessed using the GRADE approach. Main results Two cluster-randomized trials, eight non-randomized controlled studies and 22 uncontrolled before-and-after studies are included in this review. Twenty-two studies (29 comparisons) compared MDA to placebo or no intervention of which two comparisons were

  17. Woven heat exchanger

    DOEpatents

    Piscitella, R.R.

    1984-07-16

    This invention relates to a heat exchanger for waste heat recovery from high temperature industrial exhaust streams. In a woven ceramic heat exchanger using the basic tube-in-shell design, each heat exchanger consisting of tube sheets and tube, is woven separately. Individual heat exchangers are assembled in cross-flow configuration. Each heat exchanger is woven from high temperature ceramic fiber, the warp is continuous from tube to tube sheet providing a smooth transition and unitized construction.

  18. Administrator Protections in Negotiated Contracts.

    ERIC Educational Resources Information Center

    Pisapia, John Ralph; Sells, Jack D.

    1978-01-01

    Presents specific examples of provisions currently found in administrator-board collective bargaining agreements that protect administrators from the adverse effects of both bilateral decisions made by boards with teachers, and unilateral decisions made by boards concerning principals. (Author)

  19. Administrative Aspects of Human Experimentation.

    ERIC Educational Resources Information Center

    Irvine, George W.

    1992-01-01

    The following administrative aspects of scientific experimentation with human subjects are discussed: the definition of human experimentation; the distinction between experimentation and treatment; investigator responsibility; documentation; the elements and principles of informed consent; and the administrator's role in establishing and…

  20. Administration for Children and Families

    MedlinePlus

    ... Speeches Videos What is the Administration for Children & Families? The Administration for Children and Families (ACF) is ... Visit the Office of Community Services Website The Family Room Blog RSS Feed Building Community, Building Hope: ...

  1. The analysis of thermal network of district heating system from investor point of view

    NASA Astrophysics Data System (ADS)

    Takács, Ján; Rácz, Lukáš

    2016-06-01

    The hydraulics of a thermal network of a district heating system is a very important issue, to which not enough attention is often paid. In this paper the authors want to point out some of the important aspects of the design and operation of thermal networks in district heating systems. The design boundary conditions of a heat distribution network and the requirements on active pressure - circulation pump - influencing the operation costs of the centralized district heating system as a whole, are analyzed in detail. The heat generators and the heat exchange stations are designed according to the design heat loads after thermal insulation, and modern boiler units are installed in the heating plant.

  2. Regenerative adsorbent heat pump

    NASA Technical Reports Server (NTRS)

    Jones, Jack A. (Inventor)

    1991-01-01

    A regenerative adsorbent heat pump process and system is provided which can regenerate a high percentage of the sensible heat of the system and at least a portion of the heat of adsorption. A series of at least four compressors containing an adsorbent is provided. A large amount of heat is transferred from compressor to compressor so that heat is regenerated. The process and system are useful for air conditioning rooms, providing room heat in the winter or for hot water heating throughout the year, and, in general, for pumping heat from a lower temperature to a higher temperature.

  3. Solar Heating Considerations for Green Schools

    ERIC Educational Resources Information Center

    Kelley, Brian; Fiedler, Lon

    2012-01-01

    As energy costs continue to rise, many schools and universities are considering energy-saving solutions, including solar heating options, to lower costs and to attract students and staff that support environmentally friendly practices. However, administrators and facility engineers should take several issues into account before pursuing a solar…

  4. Chapter 23: Combined Heat and Power

    SciTech Connect

    Simons, George; Barsun, Stephan

    2016-11-01

    This protocol defines a combined heat and power (CHP) measure as a system that sequentially generates both electrical energy and useful thermal energy from one fuel source at a host customer's facility or residence. This protocol is aimed primarily at regulators and administrators of ratepayer-funded CHP programs; however, project developers may find the protocol useful to understand how CHP projects are evaluated.

  5. Administrative Uses of the Microcomputer.

    ERIC Educational Resources Information Center

    Spuck, Dennis W.; Atkinson, Gene

    1983-01-01

    An outline of microcomputer applications for administrative computing in education is followed by discussions of aspects of office automation, database management systems, management information systems, administrative computer systems, and software. Several potential problems relating to administrative computing in education are identified.…

  6. Administrators' Decisions about Resource Allocation

    ERIC Educational Resources Information Center

    Knight, William E.; Folkins, John W.; Hakel, Milton D.; Kennell, Richard P.

    2011-01-01

    Do academic administrators make decisions about resource allocation differently depending on the discipline receiving the funding? Does an administrator's academic identity influence these decisions? This study explored those questions with a sample of 1,690 academic administrators at doctoral-research universities. Participants used fictional…

  7. Three Generations of Educational Administration.

    ERIC Educational Resources Information Center

    Sharpe, F. G.

    This paper compares two Australian educational administration texts published in 1963 to reflect critically on the radical changes that have occurred in educational administration in Australia since then. The books are "Headmasters for Better Schools," by Bassett, Crane, and Walker; and "Training the Administrator," by…

  8. Certification of Financial Aid Administrators

    ERIC Educational Resources Information Center

    Peterson, Stacey A.

    2011-01-01

    The certification of financial aid administrators has been debated for over 37 years. A job satisfaction survey conducted by the National Association of Student Financial Aid Administrators (NASFAA, 2008a) revealed that college and university administrators' perceptions of the efficiency, effectiveness, and quality of the services provided by the…

  9. The Cultural Context of Administration.

    ERIC Educational Resources Information Center

    Ortiz, Flora Ida

    To explicate the relevance of cultural context to educational administration practices, this paper contrasts United States cultural attitudes and administrative practices with those of Latin America. Drawing on Leslie A. White's definition of culture, the author presents the Weberian model of administration as exemplary for the United States,…

  10. Comparing Administrators' Perceptions of SBM.

    ERIC Educational Resources Information Center

    Jacobson, Stephen L.; Woodworth, Beth

    The purpose of this study was to examine the perceptions of administrators of small rural districts hold about school-based management (SBM) and to compare them with the perceptions of administrators in larger, nonrural districts. Administrators' perceptions of what should occur in SBM were compared with what they perceived does occur. Responses…

  11. Central Heating and Power Plant Alternatives Review, Fort Wainwright, Alaska

    DTIC Science & Technology

    2003-05-01

    purchased from Usibelli Coal Mine, Inc. FWA maintains a coal pile for inven- tory. The typical inventory is a 90-day supply. Current Upgrade Strategy...ancillary businesses. 4. This assessment assumes that GVEA will purchase power from the nearby coal facilities (Healy and Aurora power plants) first , before...resource, which would add substantially to the costs. Typical installed costs of photo- voltaic systems are on the order $10,000/kW, or about $1 Million for

  12. Coal Gasification Processes for Retrofitting Military Central Heating Plants: Overview

    DTIC Science & Technology

    1992-11-01

    the product gas and convened to elemental sulfur by the Claus or wet oxidation processes. It is easier to remove sulfur in the form of H2S rather than...The wet oxidation process is generally more economical than the Claus process because of the low H2S content (usually less than 5 percent) in the cold...is carried out with the product gases. The fluidized-bed gasifier generally cannot handle highly caking coals without an oxidative pretreatment step

  13. A centrally heated dark halo for our Galaxy

    NASA Astrophysics Data System (ADS)

    Cole, D. R.; Binney, James

    2017-02-01

    We construct a new family of models of our Galaxy in which dark matter and disc stars are both represented by distribution functions that are analytic functions of the action integrals of motion. The potential that is self-consistently generated by the dark matter, stars, and gas is determined, and parameters in the distribution functions are adjusted until the model is compatible with observational constraints on the circular speed curve, the vertical density profile of the stellar disc near the Sun, the kinematics of nearly 200 000 giant stars within 2 kpc of the Sun, and estimates of the optical depth to microlensing of bulge stars. We find that the data require a dark halo in which the phase-space density is approximately constant for actions |J|≲ 140 kpc {km s^{-1}}. In real space, these haloes have core radii ≃2 kpc.

  14. Environmental Assessment for Decentralization of Central Heat Plant

    DTIC Science & Technology

    2005-08-01

    PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10 . SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S...Micrometers in Diameter Liability Act PM10 Particulate Matters Less Than 10 CES/CEV Civil Engineering Squadron/Civil Micrometers in Diameter Environmental...PLANT United States Air Force Dover Air Force Base, Delaware 436th Airlift Wing August 2005 10 ’! I ) I ) TABLE OF CONTENTS Section Page

  15. Central Heating Plant Coal Use Handbook. Volume 1: Technical Reference.

    DTIC Science & Technology

    1996-11-01

    specifications for a traveling grate spreader stoker 138 27 Recommended coal specifications for a vibrating grate spreader stoker 139 28 Recommended...64 19 Rail car shaker 65 20 Rail car hoe 65 21 Rotary rail car dumper 66 22 Thawing shed 66 23 Crane with clamshell bucket 68 USACERL...delivering coal from a track hopper to a bucket elevator 71 29 Screw feeder 72 30 Vibrating feeder 72 31 Reciprocating feeder 73 32 Skirtboard 74

  16. The Community College Theatre Department: An Administrative Point of Reference.

    ERIC Educational Resources Information Center

    Marine, Don

    This paper discusses aspects of faculty, administration, departmental structure, curriculum, and production operations of community college theatre departments in general and of Illinois Central College in particular. It contends that the common and revered tenet of community college institutional philosophy is "community service." The importance…

  17. 6 CFR 11.4 - Collection by administrative offset.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Program. DHS adopts the provisions of 31 CFR 901.3. (c) Non-centralized Offset for DHS Debts. When... Program as described in this section. (3) When an employee transfers to another agency, DHS should resume... Collection by administrative offset. (a) General Provisions for Offset. DHS will collect debts...

  18. Relevant Adult Programs, Resilient Students, and Retention-Driven Administration

    ERIC Educational Resources Information Center

    Beth Sullivan, Esther; Pagano, Rosanne V.

    2012-01-01

    In ten years, Alaska Pacific University has moved from a totally decentralized administration of its adult online program to a very centralized structure. Drastic changes in funding sources and student needs have compelled the university to take new approaches. As the learning landscape continues to shift for adults, online learners, and Alaska…

  19. Civil Rights in Crisis: The Reagan Administration's Reforms.

    ERIC Educational Resources Information Center

    Schroyer-Portillo, Janet

    This paper identifies major changes in the area of civil rights which have been instituted during President Reagan's term in office and discusses their implications for Hispanics. Section I briefly outlines central themes of the Administration's attitude towards civil rights. Questions about their negative impact on Hispanics are raised. The next…

  20. 41 CFR 105-55.011 - Collection by administrative offset.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) This section does not apply to— (i) Debts arising under the Social Security Act, except as provided in 42 U.S.C. 404; (ii) Payments made under the Social Security Act, except as provided for in 31 U.S.C... the Administrator. Also, the Secretary may exempt other classes of payments from centralized...

  1. 12. VIEW OF THE MANIPULATOR AND PARTS HEATING FURNACE. THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF THE MANIPULATOR AND PARTS HEATING FURNACE. THE METALS WERE HEATED PRIOR TO BEING PRESSED. THE ARM IS DRAPED WITH FIRE RESISTANT MATERIAL. (2/9/79) - Rocky Flats Plant, Uranium Rolling & Forming Operations, Southeast section of plant, southeast quadrant of intersection of Central Avenue & Eighth Street, Golden, Jefferson County, CO

  2. 19. VIEW OF THE BAKEOUT FURNACE, WHERE PARTS WERE HEATED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. VIEW OF THE BAKE-OUT FURNACE, WHERE PARTS WERE HEATED UNDER A VACUUM TO HEAT TREAT OR TO BAKE OUT ANY IMPURITIES. (9/19/72) - Rocky Flats Plant, Uranium Rolling & Forming Operations, Southeast section of plant, southeast quadrant of intersection of Central Avenue & Eighth Street, Golden, Jefferson County, CO

  3. 11. VIEW OF THE MANIPULATOR AND THE PARTS HEATING FURNACE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. VIEW OF THE MANIPULATOR AND THE PARTS HEATING FURNACE. THE PARTS OR METALS WERE HEATED PRIOR TO BEING PRESSED. THE MANIPULATOR ARM WAS USED TO INSERT AND REMOVE PARTS OR METALS FROM THE FURNACE. (2/9/79) - Rocky Flats Plant, Uranium Rolling & Forming Operations, Southeast section of plant, southeast quadrant of intersection of Central Avenue & Eighth Street, Golden, Jefferson County, CO

  4. Solar Heating System for Recreation Building at Scattergood School.

    ERIC Educational Resources Information Center

    Scattergood School, West Branch, IA.

    This report describes the solar heating of two adjoining buildings, a gymnasium and a locker room, at a coeducational boarding school. Federal assistance was obtained from the Energy Research and Development Administration (ERDA) as part of the Solar Heating and Cooling Demonstration Program. The system uses a 2,500-square-foot array of…

  5. 21 CFR 890.5730 - Moist heat pack.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Moist heat pack. 890.5730 Section 890.5730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5730 Moist heat pack....

  6. 21 CFR 890.5730 - Moist heat pack.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Moist heat pack. 890.5730 Section 890.5730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5730 Moist heat pack....

  7. 21 CFR 890.5730 - Moist heat pack.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Moist heat pack. 890.5730 Section 890.5730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5730 Moist heat pack....

  8. 21 CFR 890.5730 - Moist heat pack.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Moist heat pack. 890.5730 Section 890.5730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5730 Moist heat pack....

  9. 21 CFR 890.5730 - Moist heat pack.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Moist heat pack. 890.5730 Section 890.5730 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Therapeutic Devices § 890.5730 Moist heat pack....

  10. 14 CFR 25.833 - Combustion heating systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Combustion heating systems. 25.833 Section 25.833 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Combustion heating systems. Combustion heaters must be approved. Pressurization...

  11. 14 CFR 25.833 - Combustion heating systems.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Combustion heating systems. 25.833 Section 25.833 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... Combustion heating systems. Combustion heaters must be approved. Pressurization...

  12. 49 CFR 179.400-12 - Postweld heat treatment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.400-12 Postweld heat treatment. (a) Postweld heat treatment of the inner tank is not required. (b)...

  13. High-temperature solar central receivers

    NASA Astrophysics Data System (ADS)

    Skinrood, A. C.

    1981-07-01

    Designs and concepts for solar central receiver thermal power plants are reviewed. Concentrations of over 1,000 suns are now possible, and seven prototype plants, producing from 1-10 MWe, are close to completion, employing cavity and external receiver configurations. Heat transfer fluids are discussed, noting that the water/steam cycle is emerging as the dominant mode; liquid sodium is benefitting from extensive testing for nuclear power plants; molten salt provides thermal storage at $10-30/kWt-hr; high temperature gas systems (815 C) can be applied for gypsum board drying and NH3 production. Heliostats are all of a steel/glass configuration and require mass production to become economical. Thermal storage systems, applications for repowering in conjunction with conventional power plants, and cogeneration for electricity/process heat are examined, and power costs are projected to match those of coal if the central receiver construction costs can be halved.

  14. Heat storage module

    NASA Astrophysics Data System (ADS)

    Staehle, H. J.; Lindner, F.

    1993-02-01

    Experiments performed on TEXUS 27 sounding rocket to investigate the thermal energy storage module of solar dynamic systems are reported. One of the most suitable energy storage materials for the desired temperature range of 800 to 900 C is lithium fluoride (LiF). Due to the large volume increase during melting of approximately 22% and the corrosivity in the molten state, a canister made of graphite or glass carbon was developed for space use. The heat exchanging wall is equipped with channels and the canister is filled in such a way that molten LiF occupies the whole volume except the channels. In the discharge model, the crystallization of LiF starts at the outer wall and continues towards the center of the canister. There, a void forms due to the volume contraction. The next melting cycle starts again at the heat exchanging wall, and the surplus of volume, due to the pressure of the central void, is able to penetrate the channels against the capillary forces. As soon as the melting front reaches the void, the capillary forces drive the melt out of the channels and a new cycle can start. Tests under terrestrial conditions revealed that the melt did not penetrate the channels as long as the gravity dependent pressure did not exceed the capillary pressure. The TEXUS experiments reported were performed to clarify the following points under microgravity: the melting/freezing behavior of LiF; the formation of the void(s) (Does one void form or several voids? Where is the void located? If several voids are generated, how is their distribution?); and the predicted function of the volume compensation.

  15. An Exploratory Study of Central Office Best Practices in Washington's Top 5% Performing School Districts

    ERIC Educational Resources Information Center

    Ansingh, Pamela Jean

    2012-01-01

    How prepared are central office administrators to lead school districts in the face of changing standards and changing student populations? The purpose of this mixed methods study was to examine the responses of central office administrators in the top 5% performing school districts in Washington State with the goal of identifying common attitudes…

  16. Hitaveita (district heating) in Akureyri

    SciTech Connect

    Flovenz, O.G.; Axelsson, G.; Arnason, F.; Finnsson, M.

    1996-11-01

    Akureyri is a town of 15,000 inhabitants located in central N-Iceland. It has been heated by geothermal energy since the end of the seventies. Prior to that, it was partly heated by electricity, but mainly with oil burners, located within individual buildings. During the period 1928-1970, several attempts were made to exploit known hot spring areas in the vicinity of Akureyri. These attempts failed. Following the jump in energy price during the oil crisis of 1973, considerable effort was put into further exploration. Based on resistivity soundings, the Laugaland field was selected for deep drilling. In 1975, this resulted in the discovery of a big feed zone, which initially yielded around 100 1/s of 90{degrees}C hot water by free flow. Two years later another big feed zone was located at the Ytri-Tjarnir geothermal field initially yielding 50 1/2 of 80{degrees}C water. Based on short-term pump tests, and simulations by the Theis model, it was estimated that these two fields together could yield 240 1/s with a water level drawdown to 190 m below the surface. This was expected to satisfy the energy need for space heating in Akureyri. In 1977, Hitaveita Akureyrar was, therefore, established. Construction of the district heating system was initiated in 1976 and most of the town had been connected in 1979.

  17. Key Obama officials leave administration

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-01-01

    Secretary of the Interior Ken Salazar is one of the latest members of the Obama administration to announce that he is leaving his position near the start of President Obama's second term in office. Salazar, who has served as interior secretary since January 2009, intends to leave the department by the end of March, the department noted on 16 January. Salazar joins a number of other key officials who are planning to leave the administration. They include Environmental Protection Agency administrator Lisa Jackson, National Oceanic and Atmospheric Administration administrator Jane Lubchenco, and U.S. Geological Survey director Marcia McNutt.

  18. State Heating Oil & Propane Program. Final report 1997/98 heating season

    SciTech Connect

    Hunton, G.

    1998-06-01

    The following is a summary report of the New Hampshire Governor`s Office of Energy and Community Services (ECS) participation in the State Heating Oil and Propane Program (SHOPP) for the 1997/98 heating season. SHOPP is a cooperative effort, linking energy offices in East Coast and Midwest states, with the Department of Energy (DOE), Energy Information Administration (EIA) for the purpose of collecting retail price data for heating oil and propane. The program is funded by the participating state with a matching grant from DOE. SHOPP was initiated in response to congressional inquires into supply difficulties and price spikes of heating oil and propane associated with the winter of 1989/90. This is important to New Hampshire because heating oil controls over 55% of the residential heating market statewide. Propane controls 10% of the heating market statewide and is widely used for water heating and cooking in areas of the state where natural gas is not available. Lower installation cost, convenience, lower operating costs compared to electricity, and its perception as a clean heating fuel have all worked to increase the popularity of propane in New Hampshire and should continue to do so in the future. Any disruption in supply of these heating fuels to New Hampshire could cause prices to skyrocket and leave many residents in the cold.

  19. Wood heating handbook. Great Lakes Regional Biomass Energy Program

    SciTech Connect

    Not Available

    1985-01-01

    After reviews of the early history of the use of wood in house heating in the US, this manual has chapters on wood combustion, wood combustion equipment, sizing of wood combustion units, sizing and choosing a chimney, chimney connectors, installation of woodstove heating systems, installation of central wood heating systems, and operation and maintenance practices. Some of this information and recommendations may be hard to find in other information sources. Considerable emphasis is given to safety and fire prevention considerations. (LTN)

  20. Cold dark matter heats up.

    PubMed

    Pontzen, Andrew; Governato, Fabio

    2014-02-13

    A principal discovery in modern cosmology is that standard model particles comprise only 5 per cent of the mass-energy budget of the Universe. In the ΛCDM paradigm, the remaining 95 per cent consists of dark energy (Λ) and cold dark matter. ΛCDM is being challenged by its apparent inability to explain the low-density 'cores' of dark matter measured at the centre of galaxies, where centrally concentrated high-density 'cusps' were predicted. But before drawing conclusions, it is necessary to include the effect of gas and stars, historically seen as passive components of galaxies. We now understand that these can inject heat energy into the cold dark matter through a coupling based on rapid gravitational potential fluctuations, explaining the observed low central densities.