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Sample records for administration faa regulations

  1. 41 CFR 102-37.535 - What information must FAA provide to GSA on its administration of the public airport donation...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... FAA provide to GSA on its administration of the public airport donation program? 102-37.535 Section... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.535 What information must FAA provide to GSA on its administration...

  2. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  3. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  4. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  5. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  6. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  7. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of... responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and...

  8. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of... responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and...

  9. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of... responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and...

  10. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of... responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and...

  11. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of the Report of Excess Real Property (Standard Form 118)) given to eligible public agencies that...

  12. 41 CFR 102-37.535 - What information must FAA provide to GSA on its administration of the public airport donation...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What information must FAA provide to GSA on its administration of the public airport donation program? 102-37.535 Section... Donations to Public Airports § 102-37.535 What information must FAA provide to GSA on its administration...

  13. FAA fluorescent penetrant activities

    SciTech Connect

    Moore, D.G.; Larson, B.F.

    1997-11-01

    The Federal Aviation Administration`s Airworthiness Assurance NDI Validation Center (AANC) and the Center for Aviation Systems Reliability (CASR) are currently working to develop a liquid penetrant inspection (LPI) system evaluation capability that will support the needs of the penetrant manufacturers, commercial airline industry and the FAA. The main focus of this facility is to support the evaluation of penetrant inspection materials, penetrant systems and to apply resources to support industry needs. This paper discusses efforts to create such a facility and an initial project to produce fatigue crack specimens for evaluation of Type 1 penetrant sensitivities.

  14. FAA Perspective

    NASA Technical Reports Server (NTRS)

    Bond, Tom

    2009-01-01

    This viewgraph presentation describes the Federal Aviation Administration's perspective on improvements on aircraft icing. The most important areas that are discussed include: 1) Improvements in SLD engineering tools to meet concerns about means of compliance (MOC); and 2) 3-D iced aerodynamics.

  15. The systems approach to airport security: The FAA (Federal Aviation Administration)/BWI (Baltimore-Washington International) Airport demonstration project

    SciTech Connect

    Caskey, D.L.; Olascoaga, M.T.

    1990-01-01

    Sandia National Laboratories has been involved in designing, installing and evaluating security systems for various applications during the past 15 years. A systems approach to security that evolved from this experience was applied to aviation security for the Federal Aviation Administration. A general systems study of aviation security in the United States was concluded in 1987. One result of the study was a recommendation that an enhanced security system concept designed to meet specified objectives be demonstrated at an operational airport. Baltimore-Washington International Airport was selected as the site for the demonstration project which began in 1988 and will be completed in 1992. This article introduced the systems approach to airport security and discussed its application at Baltimore-Washington International Airport. Examples of design features that could be included in an enhanced security concept also were presented, including details of the proposed Ramps Area Intrusion Detection System (RAIDS).

  16. 14 CFR 11.25 - How does FAA issue rules?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false How does FAA issue rules? 11.25 Section 11... RULES GENERAL RULEMAKING PROCEDURES Rulemaking Procedures General § 11.25 How does FAA issue rules? (a... new regulation, or to change a current regulation, FAA will issue one or more of the...

  17. Towards FAA Certification of UAVs

    NASA Technical Reports Server (NTRS)

    Nelson, Stacy

    2003-01-01

    As of June 30, 2003, all Unmanned Aerial Vehicles (UAV), no matter how small, must adhere to the same FAA regulations as human-piloted aircraft. These regulations include certification for flying in controlled airspace and certification of flight software based on RTCA DO-178B. This paper provides an overview of the steps necessary to obtain certification, as well as a discussion about the challenges UAV's face when trying to meet these requirements. It is divided into two parts: 1) Certifications for Flying in Controlled Airspace; 2) Certification of Flight Software per RTCA DO-178B.

  18. FAA Smoke Transport Code

    SciTech Connect

    Domino, Stefan; Luketa-Hanlin, Anay; Gallegos, Carlos

    2006-10-27

    FAA Smoke Transport Code, a physics-based Computational Fluid Dynamics tool, which couples heat, mass, and momentum transfer, has been developed to provide information on smoke transport in cargo compartments with various geometries and flight conditions. The software package contains a graphical user interface for specification of geometry and boundary conditions, analysis module for solving the governing equations, and a post-processing tool. The current code was produced by making substantial improvements and additions to a code obtained from a university. The original code was able to compute steady, uniform, isothermal turbulent pressurization. In addition, a preprocessor and postprocessor were added to arrive at the current software package.

  19. An Instructional Systems Approach or FAA Student Centered Training.

    ERIC Educational Resources Information Center

    Federal Aviation Administration (DOT), Washington, DC.

    The Federal Aviation Administration (FAA) Academy has been using a systems approach as part of its training program since 1969. This booklet describes the general characteristics of an instructional system and explains the steps the FAA goes through in implementing the approach. These steps are: 1) recognize a need for training, 2) specify the…

  20. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  1. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  2. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  3. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  4. 14 CFR 47.19 - FAA Aircraft Registry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false FAA Aircraft Registry. 47.19 Section 47.19 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION General § 47.19 FAA Aircraft Registry. Each application, request, notification, or...

  5. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  6. 78 FR 29245 - U.S. General Services Administration Federal Property Management Regulations; Administrative Wage...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-20

    ... Administration Federal Property Management Regulations; Administrative Wage Garnishment AGENCY: Office of the... amending the U.S. General Services Administration Property Management Regulation (GSPMR) to remove... telephone number. The Administrative Wage Garnishment Code of Federal Regulations (CFR) Parts affected...

  7. FAA Smoke Transport Code

    2006-10-27

    FAA Smoke Transport Code, a physics-based Computational Fluid Dynamics tool, which couples heat, mass, and momentum transfer, has been developed to provide information on smoke transport in cargo compartments with various geometries and flight conditions. The software package contains a graphical user interface for specification of geometry and boundary conditions, analysis module for solving the governing equations, and a post-processing tool. The current code was produced by making substantial improvements and additions to a codemore » obtained from a university. The original code was able to compute steady, uniform, isothermal turbulent pressurization. In addition, a preprocessor and postprocessor were added to arrive at the current software package.« less

  8. Administrative Regulations: Department of Desegregation Implementation.

    ERIC Educational Resources Information Center

    Fleming, Margaret, Ed.

    Pursuant to the July 1979 Remedial Order of the Federal District Court, this document represents the Cleveland Board of Education Administrative Regulations for the desegregation of the Cleveland school system. Seventeen areas are covered by the regulations: transportation, student assignments, safety and security, community relations, student…

  9. 77 FR 40493 - Export Administration Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Parts 740, 742, 748, 750, 752, and 760 Export Administration Regulations CFR Correction In Title 15 of the Code of Federal Regulations, Parts 300 to 799, revised as...

  10. 14 CFR 39.5 - When does FAA issue airworthiness directives?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false When does FAA issue airworthiness directives? 39.5 Section 39.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS DIRECTIVES § 39.5 When does FAA issue airworthiness directives? FAA...

  11. NASA-FAA-NOAA Partnering Strategy

    NASA Technical Reports Server (NTRS)

    Colantonio, Ron

    2003-01-01

    This viewgraph presentation provides an overview of NASA-FAA (Federal Aviation Administration) and NOAA (National Oceanic and Atmospheric Administration) collaboration efforts particularly in the area of aviation and aircraft safety. Five technology areas are being jointly by these agencies: (1) aviation weather information; (2) weather products; (3) automet technologies; (4) forward looking weather sensors and (5) turbulence controls and mitigation systems. Memorandum of Agreements (MOU) between these agencies are reviewed. A general review of the pros and pitfalls of inter-agency collaborations is also presented.

  12. The FAA aging airplane program plan for transport aircraft

    NASA Technical Reports Server (NTRS)

    Curtis, Dayton; Lewis, Jess

    1992-01-01

    The Federal Aviation Administration (FAA) Aging Airplane Program is focused on five program areas: maintenance, transport airplanes, commuter airplanes, airplane engines, and research. These programs are complementary and concurrent, and have been in effect since 1988. The programs address the aging airplane challenge through different methods, including policies, procedures, and hardware development. Each program is carefully monitored and its progress tracked to ensure that the needs of the FAA, the industry, and the flying public are being met.

  13. NASA/FAA helicopter simulator workshop

    NASA Technical Reports Server (NTRS)

    Larsen, William E. (Editor); Randle, Robert J., Jr. (Editor); Bray, Richard S. (Editor); Zuk, John (Editor)

    1992-01-01

    A workshop was convened by the FAA and NASA for the purpose of providing a forum at which leading designers, manufacturers, and users of helicopter simulators could initiate and participate in a development process that would facilitate the formulation of qualification standards by the regulatory agency. Formal papers were presented, special topics were discussed in breakout sessions, and a draft FAA advisory circular defining specifications for helicopter simulators was presented and discussed. A working group of volunteers was formed to work with the National Simulator Program Office to develop a final version of the circular. The workshop attracted 90 individuals from a constituency of simulator manufacturers, training organizations, the military, civil regulators, research scientists, and five foreign countries.

  14. FAA Film Catalog.

    ERIC Educational Resources Information Center

    Federal Aviation Administration (DOT), Washington, DC.

    Some 75 films from the U.S. Department of Transportation's Federal Aviation Administration are listed in this catalog. Topics dealt with include aerodynamics, airports, aviation history and careers, flying clubs, navigation and weather. Most of the films are 16mm sound and color productions. Filmstrips requiring a 35mm projector and phonograph or…

  15. 78 FR 63276 - Interim Policy, FAA Review of Solar Energy System Projects on Federally Obligated Airports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... Federal Aviation Administration Interim Policy, FAA Review of Solar Energy System Projects on Federally... federally obligated airports to construct solar energy systems on airport property. FAA is adopting an... for measuring ocular impact of proposed solar energy systems which are effective upon publication....

  16. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false FAA/USSPACECOM Launch Notification Form A Appendix A to Part 415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part 415—FAA/USSPACECOM Launch Notification...

  17. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false FAA/USSPACECOM Launch Notification Form A Appendix A to Part 415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part 415—FAA/USSPACECOM Launch Notification...

  18. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false FAA/USSPACECOM Launch Notification Form A Appendix A to Part 415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part 415—FAA/USSPACECOM Launch Notification...

  19. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false FAA/USSPACECOM Launch Notification Form A Appendix A to Part 415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part 415—FAA/USSPACECOM Launch Notification...

  20. 7 CFR 52.1 - Administration of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... MARKETING ACT OF 1946 PROCESSED FRUITS AND VEGETABLES, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER PROCESSED FOOD PRODUCTS 1 Regulations Governing Inspection and Certification § 52.1 Administration...

  1. 7 CFR 52.1 - Administration of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... MARKETING ACT OF 1946 PROCESSED FRUITS AND VEGETABLES, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER PROCESSED FOOD PRODUCTS 1 Regulations Governing Inspection and Certification § 52.1 Administration...

  2. 7 CFR 52.1 - Administration of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... MARKETING ACT OF 1946 PROCESSED FRUITS AND VEGETABLES, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER PROCESSED FOOD PRODUCTS 1 Regulations Governing Inspection and Certification § 52.1 Administration...

  3. NDE research efforts at the FAA Center for Aviation Systems Reliability

    NASA Technical Reports Server (NTRS)

    Thompson, Donald O.; Brasche, Lisa J. H.

    1992-01-01

    The Federal Aviation Administration-Center for Aviation Systems Reliability (FAA-CASR), a part of the Institute for Physical Research and Technology at Iowa State University, began operation in the Fall of 1990 with funding from the FAA. The mission of the FAA-CASR is to develop quantitative nondestructive evaluation (NDE) methods for aircraft structures and materials including prototype instrumentation, software, techniques, and procedures and to develop and maintain comprehensive education and training programs in aviation specific inspection procedures and practices. To accomplish this mission, FAA-CASR brings together resources from universities, government, and industry to develop a comprehensive approach to problems specific to the aviation industry. The problem areas are targeted by the FAA, aviation manufacturers, the airline industry and other members of the aviation business community. This consortium approach ensures that the focus of the efforts is on relevant problems and also facilitates effective transfer of the results to industry.

  4. 75 FR 6433 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Federal Aviation Administration Notice of Availability of a Draft Environmental Assessment and Public...: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Availability of a Draft Environmental... Chicago, Illinois. SUMMARY: The Federal Aviation Administration (FAA) proposes to fund, construct,...

  5. FAA bulk technology overview for explosives detection

    NASA Astrophysics Data System (ADS)

    Novakoff, Alan K.

    1993-04-01

    The Federal Aviation Administration (FAA) is the leading federal agency responsible for encouraging and fostering the development of a safe, secure, and efficient national airspace system (NAS). Our goal is to establish an operating environment that ensures a threat-free system to preclude acts of terrorism and fatalities. As part of the process to meet this goal, our research and development activities continually search for technologies to ensure aviation security. Recent acts of terrorism against the aviation community have demonstrated an increasing level of sophistication in the design and deployment of explosive devices. In order to prevent the introduction of explosives onto an aircraft they must be detected prior to passenger and baggage loading. The Bulk Detection program is one method of developing a number of technologies that 'see' into and 'alarm' on suspect baggage. These detection devices must be capable of providing this serve with a confidence commensurate with the state-of-the- art available today. This program utilizes the expertise of government agencies, universities and industries working toward constructing their plans and executing their designs to produce the best available equipment.

  6. Summary of the FAA low data rate voice CODEC evaluation and demonstration program

    NASA Astrophysics Data System (ADS)

    Grable, Markus R.

    1990-05-01

    The Federal Aviation Administration's (FAAs) low data rate voice coder/decoder (CODEC) evaluation and demonstration program is summarized. This program will assess the performance and operational characteristics of low data rate voice digitizing equipment in an aeronautical satellite link environment for air traffic control (ATC) applications. A concern of the FAA is to achieve acceptable voice performance for ATC in the most efficient manner. The FAA will recommend a low data rate voice CODEC standard for inclusion to Aeronautical Mobile Satellite Service (AMSS) voice communications based on the program results. The Phase II CODEC evaluation and results are focused upon.

  7. Food and Drug Administration regulation and evaluation of vaccines.

    PubMed

    Marshall, Valerie; Baylor, Norman W

    2011-05-01

    The vaccine-approval process in the United States is regulated by the Center for Biologics Evaluation and Research of the US Food and Drug Administration. Throughout the life cycle of development, from preclinical studies to after licensure, vaccines are subject to rigorous testing and oversight. Manufacturers must adhere to good manufacturing practices and control procedures to ensure the quality of vaccines. As mandated by Title 21 of the Code of Regulations, licensed vaccines must meet stringent criteria for safety, efficacy, and potency.

  8. 15 CFR 30.16 - Export Administration Regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Requirements § 30.16 Export Administration Regulations. The EAR issued by the U.S. Department of Commerce, BIS, also contain some additional reporting requirements pertaining to EEI (see 15 CFR 730-774). (a) The EAR.... (see 15 CFR 758.1(b) and 772.1, definition of the United States.) (b) Requirements to place...

  9. 15 CFR 30.16 - Export Administration Regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Requirements § 30.16 Export Administration Regulations. The EAR issued by the U.S. Department of Commerce, BIS, also contain some additional reporting requirements pertaining to EEI (see 15 CFR 730-774). (a) The EAR.... (see 15 CFR 758.1(b) and 772.1, definition of the United States.) (b) Requirements to place...

  10. 15 CFR 30.16 - Export Administration Regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Requirements § 30.16 Export Administration Regulations. The EAR issued by the U.S. Department of Commerce, BIS, also contain some additional reporting requirements pertaining to EEI (see 15 CFR 730-774). (a) The EAR.... (see 15 CFR 758.1(b) and 772.1, definition of the United States.) (b) Requirements to place...

  11. 7 CFR 1150.272 - Responsibility for administration of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Procedure for Certification of Milk Producer Organizations § 1150.272 Responsibility for administration of regulations. The Dairy Division shall have the responsibility for administering the provisions of this subpart....

  12. 7 CFR 1150.272 - Responsibility for administration of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Procedure for Certification of Milk Producer Organizations § 1150.272 Responsibility for administration of regulations. The Dairy Division shall have the responsibility for administering the provisions of this subpart....

  13. 7 CFR 1150.272 - Responsibility for administration of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MILK), DEPARTMENT OF AGRICULTURE DAIRY PROMOTION PROGRAM Procedure for Certification of Milk Producer Organizations § 1150.272 Responsibility for administration of regulations. The Dairy Division shall have the responsibility for administering the provisions of this subpart....

  14. FAA Fluorescent Penetrant Laboratory Inspections

    SciTech Connect

    WINDES,CONNOR L.; MOORE,DAVID G.

    2000-08-02

    The Federal Aviation Administration Airworthiness Assurance NDI Validation Center currently assesses the capability of various non-destructive inspection (NDI) methods used for analyzing aircraft components. The focus of one such exercise is to evaluate the sensitivity of fluorescent liquid penetrant inspection. A baseline procedure using the water-washable fluorescent penetrant method defines a foundation for comparing the brightness of low cycle fatigue cracks in titanium test panels. The analysis of deviations in the baseline procedure will determine an acceptable range of operation for the steps in the inspection process. The data also gives insight into the depth of each crack and which step(s) of the inspection process most affect penetrant sensitivities. A set of six low cycle fatigue cracks produced in 6.35-mm thick Ti-6Al-4V specimens was used to conduct the experiments to produce sensitivity data. The results will document the consistency of the crack readings and compare previous experiments to find the best parameters for water-washable penetrant.

  15. 14 CFR 15.1 - Scope of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT General Procedures § 15.1 Scope of regulations. (a) These regulations apply to claims asserted under the Federal Tort Claims Act, as amended, for money damages against... consideration by the FAA of administrative claims under the Federal Tort Claims Act....

  16. 14 CFR 15.1 - Scope of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT General Procedures § 15.1 Scope of regulations. (a) These regulations apply to claims asserted under the Federal Tort Claims Act, as amended, for money damages against... consideration by the FAA of administrative claims under the Federal Tort Claims Act....

  17. 14 CFR 15.1 - Scope of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT General Procedures § 15.1 Scope of regulations. (a) These regulations apply to claims asserted under the Federal Tort Claims Act, as amended, for money damages against... consideration by the FAA of administrative claims under the Federal Tort Claims Act....

  18. 14 CFR 15.1 - Scope of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ADMINISTRATIVE CLAIMS UNDER FEDERAL TORT CLAIMS ACT General Procedures § 15.1 Scope of regulations. (a) These regulations apply to claims asserted under the Federal Tort Claims Act, as amended, for money damages against... consideration by the FAA of administrative claims under the Federal Tort Claims Act....

  19. FAA/NASA Joint University Program for Air Transportation Research 1994-1995

    NASA Technical Reports Server (NTRS)

    Remer, J. H.

    1998-01-01

    The Joint University Program for Air Transportation Research (JUP) is a coordinated set of three grants co-sponsored by the Federal Aviation Administration (FAA) and the National Aeronautics and Space Administration (NASA). Under JUP, three institutions: the Massachusetts Institute of Technology, Princeton, and Ohio Universities receive research grants and collaborate with FAA and NASA in defining and performing civil aeronautics research in a multitude of areas. Some of these disciplines are artificial intelligence, control theory, atmospheric hazards, navigation, avionics, human factors, flight dynamics, air traffic management, and electronic communications.

  20. 49 CFR 1540.115 - Threat assessments regarding citizens of the United States holding or applying for FAA...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... means the Assistant Administrator for Intelligence for TSA. Date of service means— (1) The date of... the officer next in rank below the Administrator. FAA Administrator means the Administrator of the... posing, or is known to pose— (1) A threat to transportation or national security; (2) A threat of...

  1. 49 CFR 1540.115 - Threat assessments regarding citizens of the United States holding or applying for FAA...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... means the Assistant Administrator for Intelligence for TSA. Date of service means— (1) The date of... the officer next in rank below the Administrator. FAA Administrator means the Administrator of the... posing, or is known to pose— (1) A threat to transportation or national security; (2) A threat of...

  2. 49 CFR 1540.115 - Threat assessments regarding citizens of the United States holding or applying for FAA...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... means the Assistant Administrator for Intelligence for TSA. Date of service means— (1) The date of... the officer next in rank below the Administrator. FAA Administrator means the Administrator of the... posing, or is known to pose— (1) A threat to transportation or national security; (2) A threat of...

  3. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware...

  4. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. Link to an amendment...

  5. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. Link to an amendment published at 79 FR 56986,...

  6. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. A notification to the Federal...

  7. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. A notification to the...

  8. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. A notification to the Federal...

  9. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. A notification to the Federal...

  10. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. A notification to the...

  11. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. A notification to the Federal...

  12. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. A notification to the...

  13. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. A notification to the...

  14. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false FAA/USSPACECOM Launch Notification Form A Appendix A to Part 415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part...

  15. 77 FR 66466 - General Services Administration Regulation; Information Collection; Packing List Clause

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-05

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION General Services Administration Regulation; Information Collection; Packing List Clause AGENCY... information collection documents from the General Services Administration, Regulatory Secretariat (MVCB),...

  16. 77 FR 5020 - General Services Administration Acquisition Regulation; Information Collection; GSA Form 527...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... ADMINISTRATION General Services Administration Acquisition Regulation; Information Collection; GSA Form 527... and Financial Information'' on your attached document. Fax: (202) 501-4067. Mail: General Services... provided. SUPPLEMENTARY INFORMATION: A. Purpose The General Services Administration will be requesting...

  17. 13 CFR 101.407 - May the Administrator waive these regulations?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false May the Administrator waive these regulations? 101.407 Section 101.407 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION ADMINISTRATION Intergovernmental Partnership § 101.407 May the Administrator waive these regulations?...

  18. Technology Development, Validation, and Transfer Via the FAA Airworthiness Assurance Validation

    SciTech Connect

    Perry, R.L.

    1999-04-15

    In 1991, the Federal Aviation Administration (FAA) established an Airworthiness Assurance NDI Validation Center (AANC) at Sandia National Laboratories. Its primary mission is to support technology development, validation, and transfer to industry in order to enhance the airworthiness and improve the aircraft maintenance practices of the U.S. commercial aviation industry. The Center conducts projects in a myriad of engineering disciplines. The results are placed in the public domain so that the industry at-large can reap the benefits of FAA-funded Research and Development efforts. To support the Center's goals, the FAA/AANC has set up a hangar facility at the Albuquerque International Airport which contains a collection of transport and commuter aircraft as well as other test specimens. The facility replicates a working maintenance environment by incorporating both the physical inspection difficulties as well as the environmental factors which influence maintenance reliability.

  19. 14 CFR 11.87 - Are there circumstances in which FAA may decide not to publish a summary of my petition for...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... decide not to publish a summary of my petition for exemption? 11.87 Section 11.87 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES GENERAL RULEMAKING... in which FAA may decide not to publish a summary of my petition for exemption? The FAA may...

  20. FAA Technical Center Aeronautical Data Link Research Plan

    NASA Astrophysics Data System (ADS)

    Buck, Frank; Cratch, Preston; Fischer, Terence; Lunder, Joseph; Shingledecker, Clark; Stahl, David; Sweeney, David

    1992-10-01

    The purpose of this plan is to project a clear and distinct description of the Data Link research that is to be conducted at the Federal Aviation Administration (FAA) Technical Center over the next 4 years. It explicitly defines what is to be achieved at a specific time in the future. End-to-end, high fidelity simulations will be the primary methodology for answering research questions. The end-to-end simulations identified in this plan are intended to investigate controller/aircrew integration issues using candidate Data Link hardware and software configurations. Research will also focus on testing Data Link applications in terms of their impact on controllers, aircrew, and the overall safety, efficiency, and productivity of the system. Additionally, research efforts are planned to address the most critical human factors issues surrounding Data Link.

  1. Status of the FAA flight loads monitoring program

    NASA Technical Reports Server (NTRS)

    Barnes, Terence J.; Defiore, Thomas

    1992-01-01

    In support of the Federal Aviation Administration Aging Aircraft Research Program, the Agency has established a Flight Loads Data Collection Program for Commercial Aircraft. The objectives of this Program are as follows: (1) review existing data collected by other sources including but not limited to U.S., Foreign, Military, etc.; (2) collect current operational usage data from both large and small transport aircraft; and (3) develop criteria for future generations of transports. This paper presents the status of the various programs which are completed, underway or planned. The FAA will be collecting, storing, and analyzing the data which characterize typical commercial transport operations. The airframe manufacturers will handle the task of calculating the loads and stresses.

  2. 75 FR 59102 - Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... guidance on mapping PII and supplementary PII numbers stored in the Electronic Document Access system to... Defense Acquisition Regulations System 48 CFR Part 204 Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters AGENCY: Defense Acquisition Regulations System, Department of...

  3. A perspective on the FAA approval process: Integrating rotorcraft displays, controls and workload

    NASA Technical Reports Server (NTRS)

    Green, David L.; Hart, Jake; Hwoschinsky, Peter

    1993-01-01

    The FAA is responsible for making the determination that a helicopter is safe for IFR operations in the National Airspace System (NAS). This involves objective and subjective evaluations of cockpit displays, flying qualities, procedures and human factors as they affect performance and workload. After all of the objective evaluations are completed, and all Federal Regulations have been met, FAA pilots make the final subjective judgement as to suitability for use by civil pilots in the NAS. The paper uses the flying qualities and pilot workload characteristics of a small helicopter to help examine the FAA pilot's involvement in this process. The result highlights the strengths of the process and its importance to the approval of new aircraft and equipments for civil IFR helicopter applications. The paper also identifies opportunities for improvement.

  4. FAA/NASA En Route Noise Symposium

    NASA Technical Reports Server (NTRS)

    Powell, Clemans A. (Compiler)

    1990-01-01

    Aircraft community noise annoyance is traditionally a concern only in localities near airports. The proposed introduction of large commercial airplanes with advanced turboprop propulsion systems with supersonic propellers has given rise to concerns of noise annoyance in areas previously considered not to be impacted by aircraft noise. A symposium was held to assess the current knowledge of factors important to the impact of en route noise and to aid in the formulation of FAA and NASA programs in the area. Papers were invited on human response to aircraft noise in areas with low ambient noise levels, aircraft noise heard indoors and outdoors, aircraft noise in recreational areas, detection of propeller and jet aircraft noise, and methodological issues relevant to the design of future studies.

  5. 41 CFR 105-1.101 - General Services Administration Property Management Regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-INTRODUCTION 1.1-Regulations System § 105-1.101 General Services Administration Property Management Regulations... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false General Services Administration Property Management Regulations. 105-1.101 Section 105-1.101 Public Contracts and...

  6. Scientific Self-Regulation: A Brief Primer for Research Administrators

    ERIC Educational Resources Information Center

    Atkinson, Timothy N.

    2005-01-01

    The National Academies of Science recently recommended a battery of guidelines for Academe to create an "environment" conducive to the responsible conduct of research. These guidelines affect the research administration field as a whole, as research administrators will be expected to assist in these changes. Research administrators,…

  7. 76 FR 81941 - General Services Administration Acquisition Regulation; Information Collection; Price Reductions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION General Services Administration Acquisition Regulation; Information Collection; Price Reductions.... FOR FURTHER INFORMATION CONTACT: Ms. Dana Munson, General Services Acquisition Policy Division,...

  8. 78 FR 27239 - General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... ADMINISTRATION General Services Administration Acquisition Regulation; Submission for OMB Review; Industrial... the Office of Management and Budget (OMB) a request to review and approve a reinstatement of a previously approved information collection requirement regarding industrial funding fee and sales...

  9. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  10. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  11. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  12. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  13. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  14. 47 CFR 73.4102 - FAA communications, broadcast of.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false FAA communications, broadcast of. 73.4102 Section 73.4102 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Rules Applicable to All Broadcast Stations § 73.4102 FAA...

  15. 50 CFR 260.1 - Administration of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE PROCESSED FISHERY PRODUCTS, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER PROCESSED FOOD PRODUCTS INSPECTION AND CERTIFICATION Inspection and Certification of Establishments...

  16. Discovering the Regulatory Considerations of the Federal Aviation Administration: Interviewing the Aviation Rulemaking Advisory Committee

    NASA Technical Reports Server (NTRS)

    Lu, Chien-tsung

    2005-01-01

    Maintenance Resource Management (MRM) training for aviation mechanics has become mandatory in many industrialized countries since 1998. Yet, to date, MRM training remains optional in the U.S. Interestingly, a similar safety discipline, namely Crew/Cockpit Resource Management (CRM), is mandatory for pilots, flight engineers, flight attendants, and dispatchers and is regulated in the Federal Aviation Administration s (FAA) Federal Aviation Regulations (FARs). If MRM training is important to enhance aviation technicians working behavior, the rationale to not regulate it opens a window for study. This research aims to inductively investigate the FAA s regulatory rationale concerning MRM training based on direct inputs from the FAA s Aviation Rulemaking Advisory Committee (ARAC) members. Delphi methodology associated with purposive sampling technique was adopted. The result revealed that the FAA cannot regulate MRM because the aviation industry is strongly opposed to it due to the lack of training budgets, the need of a quantifiable cost-effect analysis, concern over the FAA s inspection workforce, an ongoing voluntary alternative called the Air Transportation Surveillance System (ATOS), the government s lower priority on maintenance after 9/11, and the airlines tight embracement of operational flexibility without regulation.

  17. 77 FR 2726 - General Services Administration Acquisition Regulation; Information Collection; Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... ADMINISTRATION General Services Administration Acquisition Regulation; Information Collection; Contract Financing... 1142 was inadvertently deleted as part of the rewrite of GSAR regulations on Contract Financing. GSA... Information Collection 3090- 0080, Contract Financing Final Payment; (GSAR Part 532 and 552.232-72; GSA...

  18. FAA Pilot Knowledge Tests: Learning or Rote Memorization?

    NASA Technical Reports Server (NTRS)

    Casner, Stephen M.; Jones, Karen M.; Puentes, Antonio; Irani, Homi

    2004-01-01

    The FAA pilot knowledge test is a multiple-choice assessment tool designed to measure the extent to which applicants for FAA pilot certificates and ratings have mastered a corpus of required aeronautical knowledge. All questions that appear on the test are drawn from a database of questions that is made available to the public. The FAA and others are concerned that releasing test questions may encourage students to focus their study on memorizing test questions. To investigate this concern, we created our own database of questions that differed from FAA questions in four different ways. Our first three question types were derived by modifying existing FAA questions: (1) rewording questions and answers; (2) shuffling answers; and (3) substituting different figures for problems that used figures. Our last question type posed a question about required knowledge for which no FAA question currently exists. Forty-eight student pilots completed one of two paper-and-pencil knowledge tests that contained a mix of these experimental questions. The results indicate significantly lower scores for some question types when compared to unaltered FAA questions to which participants had prior access.

  19. 78 FR 6824 - Considerations Regarding Food and Drug Administration Review and Regulation of Drugs for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... HUMAN SERVICES Food and Drug Administration Considerations Regarding Food and Drug Administration Review and Regulation of Drugs for the Treatment of Amyotrophic Lateral Sclerosis; Public Hearing AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public hearing; request for comments. SUMMARY:...

  20. 75 FR 73984 - Amendments to General Regulations of the Food and Drug Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ...'' (62 FR 62466, November 21, 1997). This guidance document may be accessed at http://www.fda.gov... HUMAN SERVICES Food and Drug Administration 21 CFR Parts 1, 14, and 17 RIN 0910-AG55 Amendments to General Regulations of the Food and Drug Administration AGENCY: Food and Drug Administration, HHS....

  1. 7 CFR 52.1 - Administration of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT PROCESSED FRUITS AND VEGETABLES, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER PROCESSED FOOD PRODUCTS 1 Regulations Governing Inspection...

  2. 7 CFR 52.1 - Administration of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT PROCESSED FRUITS AND VEGETABLES, PROCESSED PRODUCTS THEREOF, AND CERTAIN OTHER PROCESSED FOOD PRODUCTS 1 Regulations Governing Inspection...

  3. 75 FR 33682 - Export Administration Regulations; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... most recently by the Notice of August 13, 2009 (74 FR 41325 (August 14, 2009)), has continued the EAR....; E.O. 13222, 66 FR 44025, 3 CFR, 2001 Comp., p. 783; Notice of August 13, 2009, 74 FR 41325 (August... Bureau of Industry and Security 15 CFR Part 766 RIN 0694-AE93 Export Administration...

  4. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... are implemented in the Export Administration Regulations (EAR) (15 CFR parts 730 through 774) and the International Traffic in Arms Regulations (ITAR) (22 CFR parts 120 through 130). See in particular §§ 742.2 and..., Tobacco, Firearms and Explosives Regulations in 27 CFR part 447....

  5. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... are implemented in the Export Administration Regulations (EAR) (15 CFR parts 730 through 774) and the International Traffic in Arms Regulations (ITAR) (22 CFR parts 120 through 130). See in particular §§ 742.2 and..., Tobacco, Firearms and Explosives Regulations in 27 CFR part 447....

  6. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... are implemented in the Export Administration Regulations (EAR) (15 CFR parts 730 through 774) and the International Traffic in Arms Regulations (ITAR) (22 CFR parts 120 through 130). See in particular §§ 742.2 and..., Tobacco, Firearms and Explosives Regulations in 27 CFR part 447....

  7. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... are implemented in the Export Administration Regulations (EAR) (15 CFR parts 730 through 774) and the International Traffic in Arms Regulations (ITAR) (22 CFR parts 120 through 130). See in particular §§ 742.2 and..., Tobacco, Firearms and Explosives Regulations in 27 CFR part 447....

  8. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General... accordance with the regulations of the Patent and Trademark Office 37 CFR part 5. See § 370.10(j).) ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF...

  9. 22 CFR 120.42 - Subject to the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... found at 15 CFR parts 730 through 774. ... Regulations (EAR). 120.42 Section 120.42 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.42 Subject to the Export Administration Regulations (EAR)....

  10. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General... accordance with the regulations of the Patent and Trademark Office 37 CFR part 5. See § 370.10(j).) ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF...

  11. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General... accordance with the regulations of the Patent and Trademark Office 37 CFR part 5. See § 370.10(j).) ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF...

  12. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General... accordance with the regulations of the Patent and Trademark Office 37 CFR part 5. See § 370.10(j).) ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF...

  13. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... are implemented in the Export Administration Regulations (EAR) (15 CFR parts 730 through 774) and the International Traffic in Arms Regulations (ITAR) (22 CFR parts 120 through 130). See in particular §§ 742.2 and..., Tobacco, Firearms and Explosives Regulations in 27 CFR part 447....

  14. 14 CFR 39.21 - Where can I get information about FAA-approved alternative methods of compliance?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Where can I get information about FAA-approved alternative methods of compliance? 39.21 Section 39.21 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS DIRECTIVES § 39.21 Where can I...

  15. FAA Fluorescent Penetrant Activities - An Update

    SciTech Connect

    Moore, D.G.

    1998-10-20

    The Federal Aviation Administration's Airworthiness Assurance NDI Validation Center (AANC) is currently characterizing low cycle fatigue specimens that will support the needs of penetrant manufacturers, commercial airline industry and the Federal Aviation Administration. The main focus of this characterization is to maintain and enhance the evaluation of penetrant inspection materials and apply resources to support the aircraft community needs. This paper discusses efforts to-date to document the Wright Laboratory penetrant evaluation process and characterize penetrant brightness readings in the initial set of sample calibration panels using Type 1 penetrant.

  16. 76 FR 78966 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... Federal Aviation Administration Approval of Noise Compatibility Program for Kona International Airport at Keahole, Keahole, North Kona, HI AGENCY: Federal Aviation Administration, DOT. ACTION: Notice. SUMMARY: The Federal Aviation Administration (FAA) announces its findings on the noise compatibility...

  17. Collegiate Aviation and FAA Air Traffic Control.

    ERIC Educational Resources Information Center

    Ruiz, Jose R.; Ruiz, Lorelei E.

    2003-01-01

    Based on a literature review this article describes the Air Traffic-Collegiate Training Initiative (AT-CTI) program, including objectives, the process by which postsecondary institutes become affiliated, advantages of affiliation, and the recruitment and employment of air traffic control graduates by the Federal Aviation Administration. (Contains…

  18. 75 FR 1788 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1364...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1364...: Under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35), the General...

  19. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Regulations (CFR) Parts 1-99, Parts 200-299, Parts 500-599, and Parts 600-799. Relevant sections of the FDA... Administrative Provisions A Appendix A to Subpart A of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION... Good Manufacturing Practices Pt. 26, Subpt. A, App. A Appendix A to Subpart A of Part 26—List...

  20. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Regulations (CFR) Parts 1-99, Parts 200-299, Parts 500-599, and Parts 600-799. Relevant sections of the FDA... Administrative Provisions A Appendix A to Subpart A of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION... Good Manufacturing Practices Pt. 26, Subpt. A, App. A Appendix A to Subpart A of Part 26—List...

  1. 75 FR 14448 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements... announcing a public workshop entitled ``FDA Clinical Trial Requirements, Regulations, Compliance, and Good... representatives. The program will focus on the relationships among the FDA and clinical trial staff,...

  2. 77 FR 15370 - General Services Administration Acquisition Regulation; Information Collection; Price Reductions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... date of the notice of request for comments regarding OMB Control No. 3090-0235, Price Reductions Clause, published in the Federal Register at 76 FR 81941, on December 29, 2011. DATES: Submit comments on or before... ADMINISTRATION General Services Administration Acquisition Regulation; Information Collection; Price...

  3. 77 FR 58380 - General Services Administration Acquisition Regulation; Submission for OMB Review; Price...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... ADMINISTRATION General Services Administration Acquisition Regulation; Submission for OMB Review; Price... collection requirement regarding the GSAR Price Reductions Clause. A notice was published in the Federal Register at 76 FR 89141, on December 29, 2011. One respondent submitted comments. Public comments...

  4. The Infralimbic Cortex Regulates the Consolidation of Extinction after Cocaine Self-Administration

    ERIC Educational Resources Information Center

    LaLumiere, Ryan T.; Niehoff, Kate E.; Kalivas, Peter W.

    2010-01-01

    The infralimbic cortex (IL) regulates the consolidation of extinction learning for fear conditioning. Whether the IL influences the consolidation of extinction learning for cocaine self-administration is unknown. To address this issue, male Sprague-Dawley rats underwent 2 wk of cocaine self-administration followed by extinction training. On the…

  5. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... requirement concerning cost accounting standards administration. A request for public comments was published in the Federal Register at 74 FR 58628, on November 13, 2009. No comments were received. Public... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCIES: Department...

  6. 41 CFR 102-37.530 - What are FAA's responsibilities in the donation of surplus property to public airports?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... responsibilities in the donation of surplus property to public airports? 102-37.530 Section 102-37.530 Public... MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.530 What are FAA's responsibilities in the donation of surplus property to public airports?...

  7. 41 CFR 102-37.530 - What are FAA's responsibilities in the donation of surplus property to public airports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... responsibilities in the donation of surplus property to public airports? 102-37.530 Section 102-37.530 Public... MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.530 What are FAA's responsibilities in the donation of surplus property to public airports?...

  8. 14 CFR 193.17 - How must design and production approval holders handle information they receive from the FAA...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATIONS PROTECTION OF VOLUNTARILY SUBMITTED INFORMATION § 193.17 How must design and production approval... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false How must design and production approval holders handle information they receive from the FAA under this part? 193.17 Section 193.17...

  9. 43 CFR 19.6 - Regulations respecting administration and uses of wilderness areas under jurisdiction of the...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Regulations respecting administration and... § 19.6 Regulations respecting administration and uses of wilderness areas under jurisdiction of the Secretary. Regulations respecting administration and use of areas under the jurisdiction of the...

  10. 75 FR 2457 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS Case... Regulation Supplement (DFARS) to improve the effectiveness of DoD oversight of contractor business systems.... Background Contractor business systems and internal controls are the first line of defense against...

  11. 34 CFR 299.2 - What general administrative regulations apply to ESEA programs?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... governments. Note: 34 CFR 222.13 indicates which EDGAR provisions apply to title VIII programs (Impact Aid... 34 Education 1 2011-07-01 2011-07-01 false What general administrative regulations apply to ESEA programs? 299.2 Section 299.2 Education Regulations of the Offices of the Department of Education OFFICE...

  12. 34 CFR 299.2 - What general administrative regulations apply to ESEA programs?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... governments. Note: 34 CFR 222.13 indicates which EDGAR provisions apply to title VIII programs (Impact Aid... 34 Education 1 2010-07-01 2010-07-01 false What general administrative regulations apply to ESEA programs? 299.2 Section 299.2 Education Regulations of the Offices of the Department of Education OFFICE...

  13. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  14. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  15. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  16. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  17. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  18. 32 CFR 644.314 - Rules and regulations of the General Services Administration (GSA).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Rules and regulations of the General Services Administration (GSA). 644.314 Section 644.314 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal § 644.314 Rules and regulations...

  19. 32 CFR 644.314 - Rules and regulations of the General Services Administration (GSA).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Rules and regulations of the General Services Administration (GSA). 644.314 Section 644.314 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL PROPERTY REAL ESTATE HANDBOOK Disposal § 644.314 Rules and regulations...

  20. Evaluating the compliance of Keck's LGSAO automated aircraft protection system with FAA adopted criteria

    NASA Astrophysics Data System (ADS)

    Stomski, Paul J.; Campbell, Randy; Murphy, Thomas W.

    2014-07-01

    The W. M. Keck Observatory (WMKO) applied for and received a determination of no-objection from the Federal Aviation Administration (FAA) for laser guide star adaptive optics (LGS-AO) operations using an automated aircraft protection system (APS) in late 2013. WMKO's APS, named AIRSAFE, uses transponder based aircraft detection (TBAD) to replace human aircraft spotters. The FAA required WMKO to self-certify AIRSAFE compliance with SAE Aerospace Standard 6029A: "Performance Criteria for Laser Control Measures Used for Aviation Safety"[1] (AS- 6029A). AS-6029A prescribes performance and administrative criteria for an APS; essentially, requiring AIRSAFE to adequately protect all types of aircraft, traveling at any speed, altitude, distance and direction reasonably expected in the operating environment. A description of the analysis that comprises this compliance evaluation is the main focus of this paper. Also discussed is the AIRSAFE compliance with AS-6029A administrative criteria that includes characterization of site specific air traffic, failure modes, limitations, operating procedures, preventative maintenance procedures, and periodic system test procedures.

  1. Aviation Maintenance Technology. Course Content Guides. FAA Approved Curriculum.

    ERIC Educational Resources Information Center

    Shrawder, Jack; And Others

    Course content guides are provided for the 30 courses in this aviation maintenance technology curriculum approved by the Federal Aviation Administration. Course titles are physics for technicians; aircraft information, regulations, and procedures; aircraft assembly; fundamentals of aircraft electronics; aircraft electrical components; aircraft…

  2. 76 FR 6094 - FAA Public Forum To Conduct Regulatory Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... announces an informal meeting to discuss the FAA rotorcraft rules, 14 CFR parts 27 and 29, and to gather any... Stellar, Rotorcraft Standards Staff, ASW-110, 2601 Meacham Boulevard, Fort Worth, TX 76137; telephone (817... changes to enhance rotorcraft safety. The goal is to reduce the accident/incident rate for...

  3. 14 CFR 91.1050 - Employment of former FAA employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Operations Program Management § 91.1050 Employment of former FAA employees. (a) Except as specified in paragraph (c) of this section, no fractional owner or fractional ownership program manager may knowingly... of the fractional owner or fractional ownership program manager in any matter before the...

  4. Employee Retirement Income Security Act of 1974: rules and regulations for administration and enforcement; claims procedure. Pension and Welfare Benefits Administration, Labor. Final regulation.

    PubMed

    2000-11-21

    This document contains a final regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). The regulation establishes new standards for the processing of claims under group health plans and plans providing disability benefits and further clarifies existing standards for all other employee benefit plans. The new standards are intended to ensure more timely benefit determinations, to improve access to information on which a benefit determination is made, and to assure that participants and beneficiaries will be afforded a full and fair review of denied claims. When effective, the regulation will affect participants and beneficiaries of employee benefit plans, employers who sponsor employee benefit plans, plan fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  5. Health Care Financing Administration--Fiscal year 1980 regulation plan. Notice of regulation plan.

    PubMed

    1980-06-12

    HCFA has adopted a new regulation management system which includes a process for developing a regulation plan at the beginning of each fiscal year. Each initiative in the plan is designed to achieve specific programmatic goals and objectives in accordance with priorities. The plan includes a projected schedule for publishing each regulatory initiative in priority order. The annual HCFA plan supplements the Semi-Annual Agenda of Regulations published by HHS in June and December of each year in accordance with Executive Order 12044 "Improving Federal Government Regulations" (See 43 FR 12661 published March 23, 1978), and the Department's procedures which implement the Executive Order (See 43 FR 23119 published May 30, 1978, and 44 FR 59662 published October 16, 1979). The HCFA plan includes: [1] initiatives which appear in the Semi-Annual Agenda of Regulations because HCFA and the Secretary of HHS have concluded that specific regulation changes are needed; [2] new initiatives at an early stage of consideration where HCFA and the Secretary have not yet concluded that specific regulation changes are needed; and [3] routine initiatives that provide guidelines for existing regulations. HCFA is publishing the plan to provide the public with advance notice as early as possible of regulation initiatives that are planned or under active consideration. HCFA welcomes comments on the content of the plan, the priority set for each initiative, and projected publications targets.

  6. 76 FR 2745 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Eighty-Fourth Meeting: RTCA Special Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special...

  7. 77 FR 64837 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Federal Aviation Administration Fourth Meeting: RTCA Special Committee 227, Standards of Navigation Performance AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION... 15, 2012. Kathy Hitt, Management Analyst, Business Operations Group, Federal Aviation...

  8. 77 FR 25932 - Revisions to the Export Administration Regulations (EAR): Control of Energetic Materials and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-02

    ... rule (76 FR 41958) (herein ``the July 15 proposed rule'') that set forth a framework for how articles... Administration Regulations (EAR). On November 7, 2011 (76 FR 68675) (herein ``the November 7 proposed rule...), as extended by the Notice of August 12, 2011, 76 FR 50661 (August 16, 2011), has continued the...

  9. 78 FR 45026 - Revisions to the Export Administration Regulations (EAR): Control of Military Electronic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    .... 78, No. 143 / Thursday, July 25, 2013 / Proposed Rules#0;#0; ] DEPARTMENT OF COMMERCE Bureau of..., reducing incentives for foreign manufacturers to design out and avoid U.S.-origin content and services, and... Administration Regulations: Initial Implementation of Export Control Reform'' (78 FR 22660, April 16,...

  10. 78 FR 60695 - Regulatory Reorganization; Administrative Changes to Regulations Due to the Consolidation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Fiscal Service Bureau of the Fiscal Service 31 CFR Chapter II, Parts 202-391 RIN 1510-AB31 Regulatory Reorganization; Administrative Changes to Regulations Due to the Consolidation of the Financial Management Service and the Bureau of the Public Debt Into the Bureau of the Fiscal Service AGENCY: Bureau of...

  11. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... (DFARS Case 2009-D038) in the Federal Register on January 15, 2010 (75 FR 2457). The public comment... rule, DoD published a second proposed rule with request for comments on December 3, 2010 (75 FR 75550... Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS...

  12. 77 FR 31026 - Requirements for Importing Food and Drug Administration Regulated Products Into the United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... to be discussed are FDA regulations with respect to importing pharmaceutical products, medical... meeting. SUMMARY: The Food and Drug Administration (FDA) is announcing the following meeting..., Chicago, IL 60661; 312-596-4217; email: lisa.misevicz@fda.hhs.gov . Registration: Send...

  13. 44 CFR 4.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false May the Administrator waive any provision of these regulations? 4.13 Section 4.13 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL INTERGOVERNMENTAL REVIEW OF...

  14. 44 CFR 4.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false May the Administrator waive any provision of these regulations? 4.13 Section 4.13 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL INTERGOVERNMENTAL REVIEW OF...

  15. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... technical data under the authority of this part. Export Administration Regulations 15 CFR 379.3 General... nominal cost, or obtained without costs, or are readily available at libraries open to the public. The...) Instruction in academic institutions and academic laboratories, excluding information that involves...

  16. 75 FR 28632 - Federal Housing Administration (FHA)-Temporary Exemption From Compliance With FHA's Regulation on...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT RIN 2502-ZA05 Federal Housing Administration (FHA)--Temporary Exemption From Compliance With FHA's Regulation on Property Flipping AGENCY: Office of the Assistant Secretary for...

  17. 76 FR 81363 - Federal Housing Administration (FHA): Temporary Exemption From Compliance With FHA's Regulation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-28

    ... transactions include, for example, sales by HUD of real estate-owned (REO) properties under HUD's regulations... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT 24 CFR Part 203 RIN 2502-ZA05 Federal Housing Administration (FHA):...

  18. 76 FR 76072 - Revisions to the Export Administration Regulations (EAR): Control of Gas Turbine Engines and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... Administration Regulations (EAR): Control of Gas Turbine Engines and Related Items the President Determines No... publishes this proposed rule that describes how military gas turbine engines and related articles that the... USML Category XIX the military gas turbine engines and related articles that would remain on the...

  19. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  20. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  1. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  2. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  3. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  4. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... was published in the Federal Register at 77 FR 69441, on November 19, 2012. Two respondents submitted... the Federal Register at 75 FR 3236, on January 20, 2010. Based on data from the Federal Procurement... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of...

  5. GIS and RDBMS Used with Offline FAA Airspace Databases

    NASA Technical Reports Server (NTRS)

    Clark, J.; Simmons, J.; Scofield, E.; Talbott, B.

    1994-01-01

    A geographic information system (GIS) and relational database management system (RDBMS) were used in a Macintosh environment to access, manipulate, and display off-line FAA databases of airport and navigational aid locations, airways, and airspace boundaries. This proof-of-concept effort used data available from the Adaptation Controlled Environment System (ACES) and Digital Aeronautical Chart Supplement (DACS) databases to allow FAA cartographers and others to create computer-assisted charts and overlays as reference material for air traffic controllers. These products were created on an engineering model of the future GRASP (GRaphics Adaptation Support Position) workstation that will be used to make graphics and text products for the Advanced Automation System (AAS), which will upgrade and replace the current air traffic control system. Techniques developed during the prototyping effort have shown the viability of using databases to create graphical products without the need for an intervening data entry step.

  6. Prohibited or regulated? LSD psychotherapy and the United States Food and Drug Administration.

    PubMed

    Oram, Matthew

    2016-09-01

    Over the 1950s and early 1960s, the use of the hallucinogenic drug lysergic acid diethylamide (LSD) to facilitate psychotherapy was a promising field of psychiatric research in the USA. However, during the 1960s, research began to decline, before coming to a complete halt in the mid-1970s. This has commonly been explained through the increase in prohibitive federal regulations during the 1960s that aimed to curb the growing recreational use of the drug. However, closely examining the Food and Drug Administration's regulation of LSD research in the 1960s will reveal that not only was LSD research never prohibited, but that the administration supported research to a greater degree than has been recognized. Instead, the decline in research reflected more complex changes in the regulation of pharmaceutical research and development. PMID:27194113

  7. Prohibited or regulated? LSD psychotherapy and the United States Food and Drug Administration.

    PubMed

    Oram, Matthew

    2016-09-01

    Over the 1950s and early 1960s, the use of the hallucinogenic drug lysergic acid diethylamide (LSD) to facilitate psychotherapy was a promising field of psychiatric research in the USA. However, during the 1960s, research began to decline, before coming to a complete halt in the mid-1970s. This has commonly been explained through the increase in prohibitive federal regulations during the 1960s that aimed to curb the growing recreational use of the drug. However, closely examining the Food and Drug Administration's regulation of LSD research in the 1960s will reveal that not only was LSD research never prohibited, but that the administration supported research to a greater degree than has been recognized. Instead, the decline in research reflected more complex changes in the regulation of pharmaceutical research and development.

  8. 14 CFR Appendix B to Part 187 - Fees for FAA Services for Certain Flights

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the point of exit of U.S.-controlled airspace based on FAA flight data. Fees are assessed using the... available, the best available FAA flight data will be used to calculate the entry and exit points. (2) A... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Fees for FAA Services for Certain Flights...

  9. 14 CFR Appendix B to Part 187 - Fees for FAA Services for Certain Flights

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the point of exit of U.S.-controlled airspace based on FAA flight data. Fees are assessed using the... available, the best available FAA flight data will be used to calculate the entry and exit points. (2) A... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Fees for FAA Services for Certain Flights...

  10. 14 CFR Appendix B to Part 187 - Fees for FAA Services for Certain Flights

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the point of exit of U.S.-controlled airspace based on FAA flight data. Fees are assessed using the... available, the best available FAA flight data will be used to calculate the entry and exit points. (2) A... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Fees for FAA Services for Certain Flights...

  11. 14 CFR Appendix B to Part 187 - Fees for FAA Services for Certain Flights

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the point of exit of U.S.-controlled airspace based on FAA flight data. Fees are assessed using the... available, the best available FAA flight data will be used to calculate the entry and exit points. (2) A... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Fees for FAA Services for Certain Flights...

  12. 14 CFR Appendix B to Part 187 - Fees for FAA Services for Certain Flights

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the point of exit of U.S.-controlled airspace based on FAA flight data. Fees are assessed using the... available, the best available FAA flight data will be used to calculate the entry and exit points. (2) A... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Fees for FAA Services for Certain Flights...

  13. The FAA's postmortem forensic toxicology self-evaluated proficiency test program: the second seven years.

    PubMed

    Chaturvedi, Arvind K; Craft, Kristi J; Cardona, Patrick S; Rogers, Paul B; Canfield, Dennis V

    2009-05-01

    During toxicological evaluations of samples from fatally injured pilots involved in civil aviation accidents, a high degree of quality control/quality assurance (QC/QA) is maintained. Under this philosophy, the Federal Aviation Administration (FAA) started a forensic toxicology proficiency-testing (PT) program in July 1991. In continuation of the first seven years of the PT findings reported earlier, PT findings of the next seven years are summarized herein. Twenty-eight survey samples (12 urine, 9 blood, and 7 tissue homogenate) with/without alcohols/volatiles, drugs, and/or putrefactive amine(s) were submitted to an average of 31 laboratories, of which an average of 25 participants returned their results. Analytes in survey samples were correctly identified and quantitated by a large number of participants, but some false positives of concern were reported. It is anticipated that the FAA's PT program will continue to serve the forensic toxicology community through this important part of the QC/QA for laboratory accreditations.

  14. A Survey of the Aircraft Maintenance Industry to Solicit Perceptions Regarding the Effectiveness of Recent Graduates of F.A.A. Approved Maintenance Schools.

    ERIC Educational Resources Information Center

    O'Brian, Benjamin H.

    A study examined the perceptions of employers in the aircraft maintenance industry regarding the effectiveness of recent graduates of Federal Aeronautics Administration (FAA)-approved maintenance schools. Of the 100 employers who were contacted, 68 returned usable surveys. Based on responses, it was concluded that the views of employers in the…

  15. Runways at small airports are deteriorating because of deferred maintenance: Action needed by FAA and the Congress

    NASA Astrophysics Data System (ADS)

    1982-09-01

    Runways at many small airports are deteriorating faster than necessary because airport owners--usually local governments--have deferred critical maintenance. The result is damage to the runways' basic structure and a shortened useful life if they are not repaired. Based on GAO's review of 46 airports, studies by others, and the views of FAA officials, deferred maintenance is apparently a longstanding nationwide problem. Lack of funds is cited by airport owners as the primary reason for not performing needed maintenance; however, the Federal Aviation Administration's apathy to bring about satisfactory maintenance is a contributing cause. GAO is recommending actions that FAA can take to help ensure that runways at small airports are properly maintained. The Congress should recognize the airport owners' lack of resources to properly maintain airports when considering future revisions to the Airport Improvement Program.

  16. Heckler v. Chaney: judicial and administrative regulation of capital punishment by lethal injection.

    PubMed

    Stolls, M

    1985-01-01

    Capital punishment by lethal injection, which was expected to be the most safe and effective of available methods, can produce unusually cruel and inhuman death. In Heckler v. Chaney, inmates sentenced to death by lethal injection, as well as members of both the medical and legal communities, challenged the Food and Drug Administration's (FDA) refusal to regulate certain drugs used for capital punishment by lethal injection. By declining to review the FDA's nonenforcement decision, the Supreme Court also declined an opportunity to reevaluate its standard for determining cruel and unusual punishment, which upholds any method of execution that is no more unusually cruel than existing methods. This Comment examines the propriety of judicial and administrative regulation of capital punishment by lethal injection.

  17. A case for tobacco content regulation by the U.S. Food and Drug Administration

    PubMed Central

    du Toit, J.A.

    2010-01-01

    Although many people welcome the recent move by the United States to give its Food and Drug Administration (fda) the authority to regulate the content of tobacco, some worry that such regulation constitutes unwarranted interference with the freedom of competent adult tobacco consumers. The concern for protecting the autonomy of individuals is valuable indeed, but given the highly addictive nature of tobacco products (and especially the nicotine in tobacco products), the continued use of tobacco by smokers cannot —without straining credulity—be said to be autonomous. This fact, combined with a proper construal of the fda’s role and an appreciation of the substantial morbidity and mortality associated with tobacco use, makes a strong case for content regulation. PMID:20697516

  18. FAA/NASA Joint University Program for Air Transportation Research: 1993-1994

    NASA Technical Reports Server (NTRS)

    Hueschen, Richard M. (Compiler)

    1995-01-01

    This report summarizes the research conducted during the academic year 1993-1994 under the NASA/FAA sponsored Joint University Program for Air Transportation Research. The year end review was held at Ohio University, Athens, Ohio, July 14-15, 1994. The Joint University Program is a coordinated set of three grants sponsored by NASA Langley Research Center and the Federal Aviation Administration, one each with the Massachusetts Institute of Technology (NGL-22-009-640), Ohio University (NGR-36-009-017), and Princeton University (NGL-31-001-252). Completed works, status reports, and annotated bibliographies are presented for research topics which include navigation, guidance and control theory and practice, aircraft performance, human factors, and expert systems concepts applied to aircraft and airport operations. An overview of the year's activities for each university is also presented.

  19. FAA/NASA Joint University Program for Air Transportation Research, 1992-1993

    NASA Technical Reports Server (NTRS)

    Morrell, Frederick R. (Compiler)

    1994-01-01

    The research conducted during the academic year 1992-1993 under the FAA/NASA sponsored Joint University Program for Air Transportation Research is summarized. The year end review was held at Ohio University, Athens, Ohio, 17-18 June 1993. The Joint University Program is a coordinated set of three grants sponsored by the Federal Aviation Administration and NASA Langley Research Center, one each with the Massachusetts Institute of Technology, Ohio University, and Princeton University. Completed works, status reports, and annotated bibliographies are presented for research topics, which include navigation, guidance, and control theory and practice, aircraft performance, human factors and air traffic management. An overview of the year's activities for each university is also presented.

  20. Implementing International Health Regulation (2005) in the Brazilian legal-administrative system.

    PubMed

    Lima, Yara Oyram Ramos; Costa, Ediná Alves

    2015-06-01

    The scope of this study was to analyze how the International Sanitary Regulation (ISR 2005)has been incorporated into the Brazilian legal-administrative system, in relation to sanitary control measures involving freight, means of transportation and travelers and possible alterations to health surveillance activities, competencies and procedures. This case study has been undertaken using a qualitative approach, of a descriptive and exploratory nature, using institutional data sources and interviews with key-informants involved in implementing ISR (2005). Alterations to the Brazilian legal-administrative system resulting from ISR (2005) were identified, in relation to standards, special competencies and procedures relating to sanitary controls for freight, modes of transportation and travelers. In its present form, the International Sanitary Regulation is an instrument that, in addition to introducing new international and national sanitary control concepts and elements, also helps to clarify questions that are helpful on a national level, relating to the specific competencies and procedures which will, to a certain extent, put pressure on administrative structures in the areas of sanitary control and surveillance.

  1. The Effect of Growth Hormone Administration on the Regulation of Mitochondrial Apoptosis in-Vivo

    PubMed Central

    Keane, James; Tajouri, Lotti; Gray, Bon

    2015-01-01

    The purpose of this study was to determine whether recombinant human growth hormone (rhGH) would show any significant effects on the expression of apoptosis regulating proteins in peripheral blood mononuclear cells (PBMCs). Additionally, the potential for post-transcriptional regulation of gene expression by miRNA was assessed in two cellular compartments, the cytosol and the mitochondria. Ten male subjects were subcutaneously injected with either rhGH (1 mg) or saline (0.9%) for seven consecutive days in a double-blinded fashion. Blood sampling was undertaken prior to treatment administration and over a period of three weeks following treatment cessation. Bcl-2 and Bak gene and protein expression levels were measured in PBMCs, while attention was also directed to the expression of miR-181a and miR-125b, known translational inhibitors of Bcl-2 and Bak respectively. Results showed that rhGH significantly decreased Bak protein concentrations compared to placebo samples for up to 8 days post treatment. While cytosolic miRNA expression was not found to be significantly affected by rhGH, measurement of the expression of miR-125b in mitochondrial fractions showed a significant down-regulation eight days post-rhGH administration. These findings suggest that rhGH induces short-term anti-apoptotic effects which may be partially mediated through a novel pathway that alters the concentration of mitochondrially-associated miRNAs. PMID:26057745

  2. US Food and Drug Administration international collaborations for cellular therapy product regulation

    PubMed Central

    2012-01-01

    Cellular therapy products are an emerging medical product class undergoing rapid scientific and clinical innovation worldwide. These products pose unique regulatory challenges both for countries with existing regulatory frameworks and for countries where regulatory frameworks for cellular therapy products are under development. The United States Food and Drug Administration (US FDA) has a history of productive working relationships with international regulatory authorities, and seeks to extend this to the cellular therapy field. The US FDA and its global regulatory counterparts are engaged in collaborations focused on the convergence of scientific and regulatory approaches, and the education of scientists, clinicians, regulators, and the public at large on the development of cellular therapies. PMID:23021082

  3. Allopregnanolone Elevations Following Pregnenolone Administration are Associated with Enhanced Activation of Emotion Regulation Neurocircuits

    PubMed Central

    Sripada, Rebecca K.; Marx, Christine E.; King, Anthony P.; Rampton, Jessica C.; Ho, Shaun; Liberzon, Israel

    2013-01-01

    Background The neurosteroid allopregnanolone is a potent allosteric modulator of the GABA(A) receptor with anxiolytic properties. Exogenous administration of allopregnanolone reduces anxiety, and allopregnanolone blockade impairs social and affective functioning. However, the neural mechanism whereby allopregnanolone improves mood and reduces anxiety is unknown. In particular, brain imaging has not been used to link neurosteroid effects to emotion regulation neurocircuitry. Methods To investigate the brain basis of allopregnanolone’s impact on emotion regulation, participants were administered 400mg of pregnenolone (N=16) or placebo (N=15) and underwent 3T fMRI while performing the Shifted-Attention Emotion Appraisal Task (SEAT), which probes emotional processing and regulation. Results Compared to placebo, allopregnanolone was associated with reduced activity in the amygdala and insula across all conditions. During the appraisal condition, allopregnanolone increased activity in the dorsal medial prefrontal cortex and enhanced connectivity between the amygdala and dorsal medial prefrontal cortex, an effect that was associated with reduced self-reported anxiety. Conclusions These results demonstrate that in response to emotional stimuli, allopregnanolone reduces activity in regions associated with generation of negative emotion. Furthermore, allopregnanolone may enhance activity in regions linked to regulatory processes. Aberrant activity in these regions has been linked to anxiety psychopathology. These results thus provide initial neuroimaging evidence that allopregnanolone may be a target for pharmacological intervention in the treatment of anxiety disorders, and suggest potential future directions for research into neurosteroid effects on emotion regulation neurocircuitry. PMID:23348009

  4. Regulation of rat MOR-1 gene expression after chronic intracerebroventricular administration of morphine

    PubMed Central

    ZHU, ZHI-PING; BADISA, RAMESH B.; PALM, DONALD E.; GOODMAN, CARL B.

    2012-01-01

    The μ-opioid receptor is the primary site for the action of morphine. In the present study, we investigated the regulation of the μ-opioid receptor mRNA levels in the locus ceruleus, ventral tegmental area, nucleus accumbens, and hypothalamus of the rat brain following intracerebroventricular administration of morphine for 7 days. The isolated mRNA from these regions was subjected to real-time quantitative RT-PCR to determine the regulation of μ-opioid receptor gene expression. It was observed that 7 days of treatment with morphine significantly down-regulated the μ-opioid receptor mRNA levels in the hypothalamus of the brain in comparison to the control group. However, the μ-opioid receptor levels in the locus ceruleus, ventral tegmental area, and nucleus accumbens regions remained the same as the control levels. Down-regulation of μ-opioid receptor mRNA levels in the hypothalamus region of the brain indicates the probable role of opioids to influence neuroendocrine function. The results further indicate that cellular adaptation for morphine tolerance is tissue-specific. These findings help us to understand the mechanism of morphine tolerance in various regions of the brain. PMID:22089925

  5. Potassium determinations using SEM, FAAS and XRF: some experimental notes

    NASA Astrophysics Data System (ADS)

    Liritzis, I.; Mavrikis, D.; Zacharias, N.; Sakalis, A.; Tsirliganis, N.; Polymeris, G.S.

    The calibration of Scanning Electron Microscopy coupled with Energy Dispersive X- Rays Spec-trometry (SEM-EDS) for elemental quantitative analysis is an important task for characterization, provenance and absolute dating purposes. In particular the potassium determination is an im-portant contributor to dose rate assessments in luminescence and Electron Spin Resonance (ESR) dating. Here a SEM-EDX is calibrated on different archaeological and geoarchaeological materials against standard laboratory samples as well as measured by micro X-Rays Fluorescence (μXRF) and flame atomic absorption spectroscopy (FAAS) techniques. A common linear relationship is obtained for most elements and certain rock types used and two clear linear regressions for two types of rocks; one for granite, diorite, microgranite and sediments and another ceramic sherds, soils, marble schists, breccia. Such linear regressions become readily available for a future fast, efficient and accu-rate way of potassium determination.

  6. Use of Ground Penetrating Radar at the FAA's National Airport Pavement Test Facility

    NASA Astrophysics Data System (ADS)

    Injun, Song

    2015-04-01

    The Federal Aviation Administration (FAA) in the United States has used a ground-coupled Ground Penetrating Radar (GPR) at the National Airport Pavement Test Facility (NAPTF) since 2005. One of the primary objectives of the testing at the facility is to provide full-scale pavement response and failure information for use in airplane landing gear design and configuration studies. During the traffic testing at the facility, a GSSI GPR system was used to develop new procedures for monitoring Hot Mix Asphalt (HMA) pavement density changes that is directly related to pavement failure. After reviewing current setups for data acquisition software and procedures for identifying different pavement layers, dielectric constant and pavement thickness were selected as dominant parameters controlling HMA properties provided by GPR. A new methodology showing HMA density changes in terms of dielectric constant variations, called dielectric sweep test, was developed and applied in full-scale pavement test. The dielectric constant changes were successfully monitored with increasing airplane traffic numbers. The changes were compared to pavement performance data (permanent deformation). The measured dielectric constants based on the known HMA thicknesses were also compared with computed dielectric constants using an equation from ASTM D4748-98 Standard Test Method for Determining the Thickness of Bound Pavement Layers Using Short-Pulse Radar. Six inches diameter cylindrical cores were taken after construction and traffic testing for the HMA layer bulk specific gravity. The measured bulk specific gravity was also compared to monitor HMA density changes caused by aircraft traffic conditions. Additionally this presentation will review the applications of the FAA's ground-coupled GPR on embedded rebar identification in concrete pavement, sewer pipes in soil, and gage identifications in 3D plots.

  7. Tobacco advertising and sales practices in licensed retail outlets after the Food and Drug Administration regulations.

    PubMed

    Frick, Ryan G; Klein, Elizabeth G; Ferketich, Amy K; Wewers, Mary Ellen

    2012-10-01

    To assess retailer compliance with Food and Drug Administration (FDA) regulations on tobacco sales and advertising practices, including point-of-sale advertisements, in two distinct Columbus, Ohio neighborhood groups by income. Data were gathered from a random sample of 129 licensed tobacco retailers, which included data on both exterior and interior advertisements as well as sales practices. Descriptive analyses compared retail outlets by high and low income neighborhood locations. Compliance with FDA regulations was high in the random sample of urban tobacco retail outlets. None of the retail outlets sold loose cigarettes or offered free items with purchase. Less than 10% of the outlets surveyed offered self-service access to cigarettes or smokeless tobacco products. From all surveyed retail outlets 95% had cigarette, 57% had smokeless, and 57% had cigar advertisements at the point-of-sale. There were no significant differences in compliance by income, but the mean number of advertisements on the building and self-service access to cigars was significantly different by neighborhood income. There was a high degree of compliance with the new FDA regulation on tobacco marketing and sales practices in urban retail tobacco outlets in Columbus, Ohio. Tobacco advertising and marketing remain highly prevalent in retail outlets, with some significant differences between high and low income neighborhoods.

  8. The new E.U. Animal Transport Regulation: improved welfare and health or increased administration?

    PubMed

    Hartung, J

    2006-03-01

    There is public discussion of the new E.U. Animal Transport Regulation No 1/2005 of Dec. 2004 and its advantages and draw-backs. This Regulation is no longer a Directive, so that it is directly applicable in the Members States. Although the Regulation is recognised to have great potential to improve welfare and health of transported animals, it will also increase administrative work. Most improvements will come through better education and the increased responsibilities of animal attendants, drivers, keepers and transport organisers, and through the stricter control mechanisms (log book, training, instructions etc.) and the introduction of the GPS control systems to further enhance the transparency of animal movements. The formats of the transport certificates used in all Member States will be harmonised. Technical records will be kept on air temperature and water consumption. Contact offices in all member states for transport affairs will improve the exchange of data between the responsible authorities and harmonise control and surveillance practice. Specific regulations are now in place for horses (broken, unbroken, registered) and for the transport age of young animals (piglets, lambs, calves, foals). In spite of some substantial improvements there are still significant gaps in our knowledge of both normal and long transports, for example optimal journey times, food and water supply on long transports, environmental factors such as vibration, motion, light and ventilation requirements in different European geographical regions. The same is true for the epidemiological aspects of the prevention of disease transmission; for example, very little is known about the bacterial and particulate emissions of the animal transport vehicles which travel across Europe. A serious drawback of the regulation is the fact that it does not abolish the unloading of animals on long transports to rest for 24 h at staging points, so that the concomitant risks to health and welfare

  9. 49 CFR 23.21 - Who must submit an ACDBE program to FAA, and when?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DISADVANTAGED BUSINESS ENTERPRISE IN AIRPORT CONCESSIONS ACDBE Programs § 23.21 Who must submit an ACDBE program... your revised ACDBE program is a condition of eligibility for FAA financial assistance. (3) Until your... DBE concessions program, and you apply for a grant of FAA funds for airport planning and...

  10. 49 CFR 23.21 - Who must submit an ACDBE program to FAA, and when?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DISADVANTAGED BUSINESS ENTERPRISE IN AIRPORT CONCESSIONS ACDBE Programs § 23.21 Who must submit an ACDBE program... your revised ACDBE program is a condition of eligibility for FAA financial assistance. (3) Until your... DBE concessions program, and you apply for a grant of FAA funds for airport planning and...

  11. Fracture Analysis of the FAA/NASA Wide Stiffened Panels

    NASA Technical Reports Server (NTRS)

    Seshadri, B. R.; Newman, J. C., Jr.; Dawicke, D. S.; Young, R. D.

    1998-01-01

    This paper presents the fracture analyses conducted on the FAA/NASA stiffened and unstiffened panels using the STAGS (STructural Analysis of General Shells) code with the critical crack-tip-opening angle (CTOA) fracture criterion. The STAGS code with the "plane-strain" core option was used in all analyses. Previous analyses of wide, flat panels have shown that the high-constraint conditions around a crack front, like plane strain, has to be modeled in order for the critical CTOA fracture criterion to predict wide panel failures from small laboratory tests. In the present study, the critical CTOA value was determined from a wide (unstiffened) panel with anti-buckling guides. The plane-strain core size was estimated from previous fracture analyses and was equal to about the sheet thickness. Rivet flexibility and stiffener failure was based on methods and criteria, like that currently used in industry. STAGS and the CTOA criterion were used to predict load-against-crack extension for the wide panels with a single crack and multiple-site damage cracking at many adjacent rivet holes. Analyses were able to predict stable crack growth and residual strength with a few percent (5%) of stiffened panel tests results but over predicted the buckling failure load on a unstiffened panel with a single crack by 10%.

  12. Fracture Analysis of the FAA/NASA Wide Stiffened Panels

    NASA Technical Reports Server (NTRS)

    Seshadri, B. R.; Newman, J. C., Jr.; Dawicke, D. S.; Young, R. D.

    1999-01-01

    This paper presents the fracture analyses conducted on the FAA/NASA stiffened and unstiffened panels using the STAGS (STructural Analysis of General Shells) code with the critical crack-tip-opening angle (CTOA) fracture criterion. The STAGS code with the "plane-strain" core option was used in all analyses. Previous analyses of wide, flat panels have shown that the high-constraint conditions around a crack front, like plane strain, has to be modeled in order for the critical CTOA fracture criterion to predict wide panel failures from small laboratory tests. In the present study, the critical CTOA value was determined from a wide (unstiffened) panel with anti-buckling guides. The plane-strain core size was estimated from previous fracture analyses and was equal to about the sheet thickness. Rivet flexibility and stiffener failure was based on methods and criteria, like that currently used in industry. STAGS and the CTOA criterion were used to predict load-against-crack extension for the wide panels with a single crack and multiple-site damage cracking at many adjacent rivet holes. Analyses were able to predict stable crack growth and residual strength within a few percent (5%) of stiffened panel tests results but over predicted the buckling failure load on an unstiffened panel with a single crack by 10%.

  13. Controlled impact demonstration seat/cabin restraint systems: FAA

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1986-01-01

    The FAA restraint system experiments consisted of 24 standard and modified seats, 2 standard galleys and 2 standard overhead compartments. Under the controlled impact demonstration (CID) program, the experimental objective was to demonstrate the effectiveness of individual restraint system designs when exposed to a survivable air-to-ground impact condition. What researchers were looking for was the performance exhibited by standard and modified designs, performance differences resulting from their installed cabin location, and interrelating performance demonstrated by test article and attaching floor and/or fuselage structure. The other restraint system experiment consisted of 2 standard overhead stowage compartments and 2 galley modules. Again, researchers were concerned with the retention of stowed equipment and carry-on articles. The overhead compartments were loaded with test weights up to their maximum capacity, and each of the galleys was filled with test articles: aft with normal galley equipment, forward with hazardous material test packages. A breakdown of instrumentation and distribution is given beginning with 11 instrumented type anthropomorphic dummies and 185 sensors which provided for acceleration and load measurements at the various experiment and associated structure locations. The onboard cameras provided additional coverage of these experiments, including the areas of cabin which were not instrumented. Test results showing the window-side leg forces versus pulse duration are given.

  14. 21 CFR 10.90 - Food and Drug Administration regulations, recommendations, and agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATIVE PRACTICES AND PROCEDURES General Administrative... Commissioner, e.g., model State and local ordinances, or personnel practices for reducing radiation...

  15. 21 CFR 10.90 - Food and Drug Administration regulations, recommendations, and agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATIVE PRACTICES AND PROCEDURES General Administrative... Commissioner, e.g., model State and local ordinances, or personnel practices for reducing radiation...

  16. 78 FR 25524 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... TRANSPORTATION Federal Aviation Administration Notice of Request To Release Airport Property AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Intent to Rule on Request to Release Airport Property..., Airports Compliance Specialist, Federal Aviation Administration, Airports Division, ACE- 610C, 901...

  17. 21 CFR 10.90 - Food and Drug Administration regulations, recommendations, and agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATIVE PRACTICES AND PROCEDURES General Administrative... Commissioner, e.g., model State and local ordinances, or personnel practices for reducing radiation exposure... be rescinded and has no force or effect whatever....

  18. 21 CFR 10.90 - Food and Drug Administration regulations, recommendations, and agreements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATIVE PRACTICES AND PROCEDURES General Administrative... Commissioner, e.g., model State and local ordinances, or personnel practices for reducing radiation exposure... rescinded and has no force or effect whatever....

  19. 21 CFR 10.90 - Food and Drug Administration regulations, recommendations, and agreements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATIVE PRACTICES AND PROCEDURES General Administrative... Commissioner, e.g., model State and local ordinances, or personnel practices for reducing radiation exposure... rescinded and has no force or effect whatever....

  20. Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats.

    PubMed

    Rodd, Zachary A; Bell, Richard L; Oster, Scott M; Toalston, Jamie E; Pommer, Tylene J; McBride, William J; Murphy, James M

    2010-05-01

    Several studies indicated the involvement of serotonin-3 ([5-hydroxy tryptamine] 5-HT(3)) receptors in regulating alcohol-drinking behavior. The objective of this study was to determine the involvement of 5-HT(3) receptors within the ventral tegmental area (VTA) in regulating ethanol self-administration by alcohol-preferring (P) rats. Standard two-lever operant chambers (Coulbourn Instruments, Allentown, PA) were used to examine the effects of seven consecutive bilateral microinfusions of ICS 205-930 (ICS), a 5-HT(3) receptor antagonist, directly into the posterior VTA on the acquisition and maintenance of 15% (vol/vol) ethanol self-administration. P rats readily acquired ethanol self-administration by the fourth session. The three highest doses (0.125, 0.25, and 1.25 microg) of ICS prevented acquisition of ethanol self-administration. During the acquisition postinjection period, all rats treated with ICS demonstrated higher responding on the ethanol lever, with the highest dose producing the greatest effect. In contrast, during the maintenance phase, the three highest doses (0.75, 1.0, and 1.25 microg) of ICS significantly increased responding on the ethanol lever; after the 7-day dosing regimen, responding on the ethanol lever returned to control levels. Microinfusion of ICS into the posterior VTA did not alter the low responding on the water lever and did not alter saccharin (0.0125% wt/v) self-administration. Microinfusion of ICS into the anterior VTA did not alter ethanol self-administration. Overall, the results of this study suggest that 5-HT(3) receptors in the posterior VTA of the P rat may be involved in regulating ethanol self-administration. In addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-HT(3) receptor antagonist may alter neuronal circuitry within the posterior VTA.

  1. Serotonin-3 Receptors in the Posterior Ventral Tegmental Area Regulate Ethanol Self-Administration of Alcohol-Preferring (P) Rats

    PubMed Central

    Rodd, Zachary A.; Bell, Richard L.; Oster, Scott M.; Toalston, Jamie E.; Pommer, Tylene J.; McBride, William J.; Murphy, James M.

    2015-01-01

    Several studies indicated the involvement of serotonin-3 (5-HT3) receptors in regulating alcohol-drinking behavior. The objective of this study was to determine the involvement of 5-HT3 receptors within the ventral tegmental area (VTA) in regulating ethanol self-administration by alcohol-preferring (P) rats. Standard two-lever operant chambers were used to examine the effects of 7 consecutive bilateral micro-infusions of ICS205-930 (ICS), a 5-HT3 receptor antagonist, directly into the posterior VTA on the acquisition and maintenance of 15% (v/v) ethanol self-administration. P rats readily acquired ethanol self-administration by the 4th session. The three highest doses (0.125, 0.25 and 1.25 ug) of ICS prevented acquisition of ethanol self-administration. During the acquisition post-injection period, all rats treated with ICS demonstrated higher responding on the ethanol lever, with the highest dose producing the greatest effect. In contrast, during the maintenance phase, the 3 highest doses (0.75, 1.0 and 1.25 ug) of ICS significantly increased responding on the ethanol lever; following the 7-day dosing regimen, responding on the ethanol lever returned to control levels. Micro-infusion of ICS into the posterior VTA did not alter the low responding on the water lever, and did not alter saccharin (0.0125% w/v) self-administration.. Micro-infusion of ICS into the anterior VTA did not alter ethanol self-administration. Overall, the results of this study suggest that 5-HT3 receptors in the posterior VTA of the P rat may be involved in regulating ethanol self-administration. In addition, chronic operant ethanol self-administration, and/or repeated treatments with a 5-HT3 receptor antagonist may alter neuronal circuitry within the posterior VTA. PMID:20682192

  2. 77 FR 59790 - General Services Administration Acquisition Regulation (GSAR); Rewrite of Part 504...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... October 9, 2008, GSA published in the Federal Register at 73 FR 59589 a proposed rule with a request for... (GSAR); Rewrite of Part 504; Administrative Matters AGENCY: Office of Acquisition Policy, General... Administrative Matters and Forms. This final rule is part of the General Services Administration...

  3. Precision Departure Release Capability (PDRC): NASA to FAA Research Transition

    NASA Technical Reports Server (NTRS)

    Engelland, Shawn; Davis, Thomas J.

    2013-01-01

    departure runway assignments to the Center scheduling tool. The PDRC concept also incorporates earlier NASA and FAA research into automation-assisted CFR coordination. The PDRC concept reduces uncertainty by automatically communicating coordinated release times with seconds-level precision enabling TMCs and FLMs to work with target times rather than windows. NASA has developed a PDRC prototype system that integrates the Center's TMA system with a research prototype Tower decision support tool. A two-phase field evaluation was conducted at NASA's North Texas Research Station in Dallas-Fort Worth. The field evaluation validated the PDRC concept and demonstrated reduced release time uncertainty while being used for tactical departure scheduling of more than 230 operational flights over 29 weeks of operations.

  4. 75 FR 1020 - Amendments to the Export Administration Regulations (EAR) Based Upon the Accession of Albania and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Part 738 RIN 0694-AE62 Amendments to the Export Administration Regulations (EAR) Based Upon the Accession of Albania and Croatia to Formal Membership in the North...

  5. Education Department General Administrative Regulations. 34 CFR Parts 74, 75, 76, 77, 79, 80, 81, 82, 85 and 86.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    During calendar year 1994, the U.S. Department of Education published significant revisions to the Education Department General Administrative Regulations (EDGAR). These regulatory changes addressed the noncompeting continuation (NCC) application process for discretionary grants and cooperative agreements, the Department's implementation of the…

  6. 14 CFR 61.41 - Flight training received from flight instructors not certificated by the FAA.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the FAA. (a) A person may credit flight training toward the requirements of a pilot certificate or... Armed Force in a program for training military pilots of either— (i) The United States; or (ii)...

  7. 14 CFR 61.41 - Flight training received from flight instructors not certificated by the FAA.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the FAA. (a) A person may credit flight training toward the requirements of a pilot certificate or... Armed Force in a program for training military pilots of either— (i) The United States; or (ii)...

  8. 14 CFR 147.8 - Employment of former FAA employees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Section 147.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES AVIATION MAINTENANCE TECHNICIAN SCHOOLS General § 147.8... aviation maintenance technician certificate may knowingly employ or make a contractual arrangement...

  9. 14 CFR 147.8 - Employment of former FAA employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Section 147.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES AVIATION MAINTENANCE TECHNICIAN SCHOOLS General § 147.8... aviation maintenance technician certificate may knowingly employ or make a contractual arrangement...

  10. 14 CFR 147.8 - Employment of former FAA employees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Section 147.8 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES AVIATION MAINTENANCE TECHNICIAN SCHOOLS General § 147.8... aviation maintenance technician certificate may knowingly employ or make a contractual arrangement...

  11. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats.

    PubMed

    Logrip, Marian L; Vendruscolo, Leandro F; Schlosburg, Joel E; Koob, George F; Zorrilla, Eric P

    2014-06-01

    A history of stress produces increases in rodent relapse-like alcohol self-administration behavior and regional brain gene expression of phosphodiesterase 10A (PDE10A), a dual-specificity cyclic adenosine monophosphate/cyclic guanosine monophosphate-inhibiting enzyme. Here, we tested the hypothesis that administration of TP-10, a specific PDE10A inhibitor, would reduce alcohol self-administration in conditions predisposing to elevated self-administration. TP-10 administration dose-dependently (0.562, 1.0 mg/kg; subcutaneously) reduced relapse-like alcohol self-administration regardless of stress history enhancement of relapse-like behavior. TP-10 also reduced alcohol self-administration in genetically alcohol-preferring rats, as well as in alcohol-non-dependent and -dependent rats. Effective systemic TP-10 doses did not alter alcohol pharmacokinetics, significantly reduce motor activity or intrabout operant response speed, or promote a conditioned place aversion. TP-10 also reduced saccharin self-administration, suggesting a general role for PDE10A in the self-administration of reinforcing substances. PDE10A inhibition in the dorsolateral striatum, but not the nucleus accumbens, reduced alcohol self-administration. Taken together, the results implicate dorsolateral striatum PDE10A in facilitating alcohol intake and support further investigation of PDE10A systems in the pathophysiology and potential treatment of substance use disorders.

  12. Summary of the industry/NASA/FAA workshop on philosophy of automation: Promises and realities

    NASA Technical Reports Server (NTRS)

    Norman, Susan D.

    1990-01-01

    Issues of flight deck automation are multi-faceted and complex. The rapid introduction of advanced computer based technology on to the flight deck of transport category aircraft has had considerable impact on both aircraft operations and the flight crew. As part of NASA's responsibility to facilitate an active exchange of ideas and information between members of the aviation community, an Industry/NASA/FAA workshop was conducted in August 1988. One of the most important conclusions to emerge from the workshop was that the introduction of automation has clearly benefited aviation and has substantially improved the operational safety and efficiency of our air transport system. For example, one carrier stated that they have been flying the Boeing 767 (one of the first aircraft to employ substantial automation) since 1982, and they have never had an accident or incident resulting in damage to the aircraft. Notwithstanding its benefits, many issues associated with the design, certification, and operation of automated aircraft were identified. For example two key conceptual issues were the need for the crew to have a thorough understanding of the system and the importance of defining the pilot's role. With respect to certification, a fundamental issue is the lack of comprehensive human factors requirements in the current regulations. Operational considerations, which have been a factor in incidents involving automation, were also cited. Viewgraphs used in the presentation are given.

  13. Federal Aviation Administration retained savings program proposal

    SciTech Connect

    Hostick, D.J.; Larson, L.L.; Hostick, C.J.

    1998-03-01

    Federal legislation allows federal agencies to retain up to 50% of the savings associated with implementing energy efficiency and water conservation measures and practices. Given budget pressures to reduce expenditures, the use of retained savings to fund additional projects represents a source of funds outside of the traditional budget cycle. The Southwest Region Federal Aviation Administration (FAA) has tasked Pacific Northwest National Laboratory (PNNL) to develop a model retained savings program for Southwest Region FAA use and as a prototype for consideration by the FAA. PNNL recommends the following steps be taken in developing a Southwest Region FAA retained savings program: Establish a retained savings mechanism. Determine the level at which the retained savings should be consolidated into a fund. The preliminary recommendation is to establish a revolving efficiency loan fund at the regional level. Such a mechanism allows some consolidation of savings to fund larger projects, while maintaining a sense of facility ownership in that the funds will remain within the region.

  14. 76 FR 17138 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements... public workshop on FDA's clinical trial requirements is designed to aid the clinical research... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical...

  15. 77 FR 8886 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements... public workshop on FDA's clinical trial requirements is designed to aid the clinical research... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical...

  16. 76 FR 78933 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements... workshop. The public workshop on FDA's clinical trial requirements is designed to aid the clinical research... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical...

  17. 76 FR 51040 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements... workshop. The public workshop on FDA's clinical trial requirements is designed to aid the clinical research... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical...

  18. 75 FR 51824 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements... workshop. The public workshop on FDA's clinical trial requirements is designed to aid the clinical research... interaction with FDA representatives. The program will focus on the relationships among FDA and clinical...

  19. 75 FR 1788 - General Services Administration Regulation; Submission for OMB Review; Packing List Clause

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... comments was published in the Federal Register at 74 FR 52811, October 14, 2009. No comments were received... Administration, 1800 F Street, NW., Room 4041, Washington, DC 20405. Please cite OMB Control No. 3090-0246... General Services Administration, Regulatory Secretariat (MVPR), 1800 F Street, NW., Room 4041,...

  20. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Administrative Provisions A Appendix A to Subpart A of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION... Good Manufacturing Practices Pt. 26, Subpt. A, App. A Appendix A to Subpart A of Part 26—List of... and veterinary use and establishing a European Agency for the Evaluation of Medicinal...

  1. 75 FR 48872 - General Services Administration Acquisition Regulation; Rewrite of GSAR Part 541, Acquisition of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-12

    ... must provide that the limit can only be increased by affirmative action of the Government. Comment: The... Administration (GSA). ACTION: Final rule. SUMMARY: The General Services Administration (GSA) is amending the... Federal Register at 71 FR 7910, an Advanced Notice of Proposed Rulemaking (ANPR) with a request...

  2. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Regulations (CFR) Parts 1-99, Parts 200-299, Parts 500-599, and Parts 600-799. Relevant sections of the FDA... Directive 65/65/EEC of 26 January 1965 on the approximation of provisions laid down by law, regulation, or... Directive 75/319/EEC of 20 May 1975 on the approximation of provisions laid down by law, regulation...

  3. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Regulations (CFR) Parts 1-99, Parts 200-299, Parts 500-599, and Parts 600-799. Relevant sections of the FDA... Directive 65/65/EEC of 26 January 1965 on the approximation of provisions laid down by law, regulation, or... Directive 75/319/EEC of 20 May 1975 on the approximation of provisions laid down by law, regulation...

  4. μ Opioid Receptor Expression after Morphine Administration Is Regulated by miR-212/132 Cluster.

    PubMed

    Garcia-Concejo, Adrian; Jimenez-Gonzalez, Ada; Rodríguez, Raquel E

    2016-01-01

    Since their discovery, miRNAs have emerged as a promising therapeutical approach in the treatment of several diseases, as demonstrated by miR-212 and its relation to addiction. Here we prove that the miR-212/132 cluster can be regulated by morphine, through the activation of mu opioid receptor (Oprm1). The molecular pathways triggered after morphine administration also induce changes in the levels of expression of oprm1. In addition, miR-212/132 cluster is actively repressing the expression of mu opioid receptor by targeting a sequence in the 3' UTR of its mRNA. These findings suggest that this cluster is closely related to opioid signaling, and function as a post-transcriptional regulator, modulating morphine response in a dose dependent manner. The regulation of miR-212/132 cluster expression is mediated by MAP kinase pathway, CaMKII-CaMKIV and PKA, through the phosphorylation of CREB. Moreover, the regulation of both oprm1 and of the cluster promoter is mediated by MeCP2, acting as a transcriptional repressor on methylated DNA after prolonged morphine administration. This mechanism explains the molecular signaling triggered by morphine as well as the regulation of the expression of the mu opioid receptor mediated by morphine and the implication of miR-212/132 in these processes. PMID:27380026

  5. μ Opioid Receptor Expression after Morphine Administration Is Regulated by miR-212/132 Cluster

    PubMed Central

    Garcia-Concejo, Adrian; Jimenez-Gonzalez, Ada; Rodríguez, Raquel E.

    2016-01-01

    Since their discovery, miRNAs have emerged as a promising therapeutical approach in the treatment of several diseases, as demonstrated by miR-212 and its relation to addiction. Here we prove that the miR-212/132 cluster can be regulated by morphine, through the activation of mu opioid receptor (Oprm1). The molecular pathways triggered after morphine administration also induce changes in the levels of expression of oprm1. In addition, miR-212/132 cluster is actively repressing the expression of mu opioid receptor by targeting a sequence in the 3’ UTR of its mRNA. These findings suggest that this cluster is closely related to opioid signaling, and function as a post-transcriptional regulator, modulating morphine response in a dose dependent manner. The regulation of miR-212/132 cluster expression is mediated by MAP kinase pathway, CaMKII-CaMKIV and PKA, through the phosphorylation of CREB. Moreover, the regulation of both oprm1 and of the cluster promoter is mediated by MeCP2, acting as a transcriptional repressor on methylated DNA after prolonged morphine administration. This mechanism explains the molecular signaling triggered by morphine as well as the regulation of the expression of the mu opioid receptor mediated by morphine and the implication of miR-212/132 in these processes. PMID:27380026

  6. Impact of implementing an Internal Bed Regulation Committee on administrative and care indicators at a teaching hospital

    PubMed Central

    Rodrigues, Luciane Cristine Ribeiro; Juliani, Carmen Maria Casquel Monti

    2015-01-01

    Objective To compare hospital indicators before and after implementing an Internal Bed Regulation Committee at a reference hospital. Methods It is an quantitative, evaluation, exploratory, descriptive and cross-sectional research. The data was gathered from the hospital administrative reports for the period 2008-2013, provided by the Information Technology Center of the Complexo FAMEMA. Results The indicators improved after implementation of the Internal Bed Regulation Committee. Conclusion The individuals involved in the process acknowledged the improvement. It is necessary to carry on the regulatory actions, especially in a comprehensive and complex healthcare system, such as the brazilian Sistema Único de Saúde. PMID:25993075

  7. Regulation of lipid droplet-associated proteins following growth hormone administration and feed restriction in lactating Holstein cows.

    PubMed

    Faylon, M P; Koltes, D E; Spurlock, D M

    2014-05-01

    Lipid metabolism plays a crucial role in the adaptation of dairy cows to periods of energy insufficiency. The objective of the current study was to determine if lipolytic proteins are consistently regulated when energy mobilization is stimulated by different factors. We evaluated 2 models of altered energy balance in mid-lactation Holstein cows, including feed restriction (FR) and administration of bovine growth hormone (GH), by quantifying the abundance and (or) phosphorylation of hormone-sensitive lipase (HSL), perilipin (PLIN), and adipose triglyceride lipase (ATGL). For GH administration, adipose tissue and blood samples were collected 4d before and 3 and 7d after administration of GH (n=20 cows). Similarly, adipose and blood samples were obtained 6d before and 1 and 4d after initiation of FR (n=18 cows). Estimated net energy balance decreased and nonesterified fatty acid concentration increased in both experimental models. Decreased ATGL and PLIN protein abundance was observed with GH administration and FR. Additionally, the abundance of phosphorylated HSLSer565 decreased in both models. Decreased abundance of phosphorylated PLIN was observed with GH administration, but not FR. Decreased ATGL protein abundance appears to be a consistent response to energy insufficiency in lactating cows, as this response was also described with negative energy balance at the onset of lactation. In contrast, the abundance of PLIN protein and phosphorylation of HSL using antibodies targeting serine residue 565 of HSL (HSLSer565) were altered in the current research, but not at the onset of lactation. Our findings demonstrate that lipolysis is altered through the regulation of multiple proteins, and that this regulation differs according to physiological state in lactating cows. PMID:24630665

  8. 75 FR 12809 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... Federal Aviation Administration Notice of Intent To Rule on Request To Release Airport Property at the Dallas/Fort Worth International Airport, DFW Airport, Texas AGENCY: Federal Aviation Administration (FAA... provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR...

  9. 76 FR 54928 - Export Administration Regulations: Netherlands Antilles, Curaçao, Sint Maarten and Timor-Leste

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... Administration Regulations (EAR), e.g., the Commerce Country Chart, the Country Groups, and License Exception APP... Services, Bureau of Industry and Security, U.S. Department of Commerce at 202-482-2440 or by e-mail....S.C. app. 5; 22 U.S.C. 7201 et seq.; 22 U.S.C. 7210; E.O. 13026, 61 FR 58767, 3 CFR, 1996 Comp.,...

  10. An Investigation Into Criteria Commonly Used by the FAA to Grant Relief to Part 135 Operators Under FAR Sections: 135.213, 135.219, and/or 135.225

    NASA Technical Reports Server (NTRS)

    Williams, Louis J.; Heck, Michael L.; Burgess, Malcolm A.; Stough, H. P. (Technical Monitor)

    2002-01-01

    The objective of this study was to determine the criteria commonly used by the FAA to grant waivers, exemptions, or deviations to FAR Part 135, Sections 135.213, 135.219, and 135.225 and the potential impact on Flight Information Services Data Link (FISDL) implementation. These aviation regulations address the requirements for the use of weather reports or forecasts when conducting operations under FAR Part 135. In this study a literature search was conducted to obtain historical records of requests for relief from the 3 FAR sections under consideration. The exemption request records were then analyzed in order to determine the reasons given by the FAA for either granting or denying the request. In addition, FAA personnel and Part 135 operators were interviewed to determine the procedures used for satisfying the requirements of the 3 FAR sections.

  11. Guidelines for Federal Aviation Administration Regional Aviation Education Coordinators and Aviation Education Facilitators.

    ERIC Educational Resources Information Center

    Strickler, Mervin K., Jr.

    This publication is designed to provide both policy guidance and examples of how to work with various constituencies in planning and carrying out appropriate Federal Aviation Administration (FAA) aviation education activities. Information is provided on the history of aerospace/aviation education, FAA educational materials, aerospace/aviation…

  12. 77 FR 71099 - Federal Housing Administration (FHA): Temporary Waiver of FHA's Regulation on Property Flipping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-29

    ... transactions include sales by HUD of real estate-owned (REO) properties under HUD's regulations in 24 CFR part... Register on May 21, 2010, at 75 FR 28633. The May 2010 notice waived HUD's regulations through December 31... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOUSING...

  13. 76 FR 8892 - Removal of Expired Federal Aviation Administration Regulations and References

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... and are not currently in effect. This technical amendment is necessary to update our regulations. The... passed. To maintain an accurate body of regulations, we are removing and/or amending SFAR Nos. 36, 80, 92... recordkeeping requirements. 14 CFR Part 61 Aircraft, Airmen, Alcohol abuse, Aviation safety, Drug...

  14. Hypocretin/Orexin Regulation of Dopamine Signaling and Cocaine Self-Administration Is Mediated Predominantly by Hypocretin Receptor 1

    PubMed Central

    2015-01-01

    Extensive evidence suggests that the hypocretins/orexins influence cocaine reinforcement and dopamine signaling via actions at hypocretin receptor 1. By comparison, the involvement of hypocretin receptor 2 in reward and reinforcement processes has received relatively little attention. Thus, although there is some evidence that hypocretin receptor 2 regulates intake of some drugs of abuse, it is currently unclear to what extent hypocretin receptor 2 participates in the regulation of dopamine signaling or cocaine self-administration, particularly under high effort conditions. To address this, we examined the effects of hypocretin receptor 1, and/or hypocretin receptor 2 blockade on dopamine signaling and cocaine reinforcement. We used in vivo fast scan cyclic voltammetry to test the effects of hypocretin antagonists on dopamine signaling in the nucleus accumbens core and a progressive ratio schedule to examine the effects of these antagonists on cocaine self-administration. Results demonstrate that blockade of either hypocretin receptor 1 or both hypocretin receptor 1 and 2 significantly reduces the effects of cocaine on dopamine signaling and decreases the motivation to take cocaine. In contrast, blockade of hypocretin receptor 2 alone had no significant effects on dopamine signaling or self-administration. These findings suggest a differential involvement of the two hypocretin receptors, with hypocretin receptor 1 appearing to be more involved than hypocretin receptor 2 in the regulation of dopamine signaling and cocaine self-administration. When considered with the existing literature, these data support the hypothesis that hypocretins exert a permissive influence on dopamine signaling and motivated behavior via preferential actions on hypocretin receptor 1. PMID:25496218

  15. Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1.

    PubMed

    Prince, Courtney D; Rau, Andrew R; Yorgason, Jordan T; España, Rodrigo A

    2015-01-21

    Extensive evidence suggests that the hypocretins/orexins influence cocaine reinforcement and dopamine signaling via actions at hypocretin receptor 1. By comparison, the involvement of hypocretin receptor 2 in reward and reinforcement processes has received relatively little attention. Thus, although there is some evidence that hypocretin receptor 2 regulates intake of some drugs of abuse, it is currently unclear to what extent hypocretin receptor 2 participates in the regulation of dopamine signaling or cocaine self-administration, particularly under high effort conditions. To address this, we examined the effects of hypocretin receptor 1, and/or hypocretin receptor 2 blockade on dopamine signaling and cocaine reinforcement. We used in vivo fast scan cyclic voltammetry to test the effects of hypocretin antagonists on dopamine signaling in the nucleus accumbens core and a progressive ratio schedule to examine the effects of these antagonists on cocaine self-administration. Results demonstrate that blockade of either hypocretin receptor 1 or both hypocretin receptor 1 and 2 significantly reduces the effects of cocaine on dopamine signaling and decreases the motivation to take cocaine. In contrast, blockade of hypocretin receptor 2 alone had no significant effects on dopamine signaling or self-administration. These findings suggest a differential involvement of the two hypocretin receptors, with hypocretin receptor 1 appearing to be more involved than hypocretin receptor 2 in the regulation of dopamine signaling and cocaine self-administration. When considered with the existing literature, these data support the hypothesis that hypocretins exert a permissive influence on dopamine signaling and motivated behavior via preferential actions on hypocretin receptor 1. PMID:25496218

  16. 78 FR 303 - General Services Administration Acquisition Regulation; Information Collection; Proposal To Lease...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-03

    ... and Budget (OMB) a request to review and approve an extension of a previously approved information... required by regulation, but necessary to (1) evaluate whether the physical attributes of offered...

  17. 77 FR 35310 - Revisions to the Export Administration Regulations (EAR): Control of Military Training Equipment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-13

    ... Administration's ongoing Export Control Reform Initiative, BIS published a proposed rule (76 FR 41958) (herein... 7, 2011, BIS published a rule (76 FR 68675) proposing several changes to the framework initially..., ``specially designed'' for military applications, it was identified in the new ECCNs proposed in this...

  18. 77 FR 22191 - Revisions to the Export Administration Regulations (EAR): Export Control Classification Number...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... Administrative practice and procedure, Exports, Inventions and patents, Research science and technology. 15 CFR... identified in an existing ECCN. As BIS explained in the proposed rule issued on July 15, 2011 (76 FR 41958... Initiative, the Bureau of Industry and Security (BIS) published a proposed rule (76 FR 41958) (herein...

  19. Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration

    ERIC Educational Resources Information Center

    Smagula, Cynthia S.; Self, David W.; Choi, Kwang-Ho; Simmons, Diana; Walker, John R.

    2004-01-01

    Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic…

  20. 78 FR 57156 - General Services Administration Acquisition Regulation; Submission for OMB Review; Modifications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-17

    ... Acquisition Policy Division, GSA, 202-357-9652 or email Dana.Munson@gsa.gov for clarification of content. For... Services Administration, Regulatory Secretariat Division (MVCB), 2250C, 1800 F Street NW., Washington, DC...-72 Modifications (Multiple Award Schedule), is being reinstated at GSAR 552.238-81,...

  1. 78 FR 43972 - Amendments to the Export Administration Regulations: Implementation of Limited Syria Waiver for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ...). See 69 FR 26766 (May 14, 2004). In addition, BIS later made administrative changes to General Order No.... See 74 FR 77115 (Dec. 12, 2011). On June 12, 2013, the Secretary of State exercised authority..., 2001 (3 CFR, 2001 Comp., p. 783 (2002)), as amended by Executive Order 13637 of March 8, 2013, 78...

  2. 77 FR 69768 - General Services Administration Acquisition Regulation (GSAR); Rewrite of Part 504...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... (GSA) published a document in the Federal Register on October 1, 2012 (77 FR 59790), revising... published in the Federal Register at 77 FR 59790 on October 1, 2012 contained a typographical error. This...); Rewrite of Part 504, Administrative Matters; Correction AGENCY: Office of Acquisition Policy,...

  3. 75 FR 73951 - Amendments to General Regulations of the Food and Drug Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... procedures for issuing a direct final rule? In the Federal Register of November 21, 1997 (62 FR 62466), FDA... document entitled ``Guidance for FDA and Industry: Direct Final Rule Procedures'' (62 FR 62466). This... HUMAN SERVICES Food and Drug Administration 21 CFR Parts 1, 14, and 17 RIN 0910-AG55 Amendments...

  4. 39 CFR 233.9 - Regulations governing remission or mitigation of administrative, civil, and criminal forfeitures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... related crime would be any offense involving a violation of the Federal laws relating to drugs, or the... considering remission or mitigation of administrative forfeitures under the jurisdiction of the Postal... and, where required, took all reasonable steps under the circumstances to ensure that such...

  5. FAA Airworthiness Assurance NDI Validation Center (AANC) operated by Sandia National Laboratories.

    SciTech Connect

    Roach, Dennis Patrick; Hartman, Roger D.

    2010-09-01

    Airworthiness Assurance NDI Validation Center (AANC) objectives are: (1) Enhance aircraft safety and reliability; (2) Aid developing advanced aircraft designs and maintenance techniques; (3) Provide our customers with comprehensive, independent, and quantitative/qualitative evaluations of new and enhanced inspection, maintenance, and repair techniques; (4) Facilitate transferring effective technologies into the aviation industry; (5) Support FAA rulemaking process by providing guidance on content & necessary tools to meet requirements or recommendations of FARs, ADs, ACs, SBs, SSIDs, CPCP, and WFD; and (6) Coordinate with and respond to Airworthiness Assurance Working Group (AAWG) in support of FAA Aviation Rulemaking Advisory Committee (ARAC).

  6. Region-specific up-regulation of oxytocin receptor binding in the brain of mice following chronic nicotine administration.

    PubMed

    Zanos, Panos; Georgiou, Polymnia; Metaxas, Athanasios; Kitchen, Ian; Winsky-Sommerer, Raphaelle; Bailey, Alexis

    2015-07-23

    Nicotine addiction is considered to be the main preventable cause of death worldwide. While growing evidence indicates that the neurohypophysial peptide oxytocin can modulate the addictive properties of several abused drugs, the regulation of the oxytocinergic system following nicotine administration has so far received little attention. Here, we examined the effects of long-term nicotine or saline administration on the central oxytocinergic system using [(125)I]OVTA autoradiographic binding in mouse brain. Male, 7-week old C57BL6J mice were treated with either nicotine (7.8 mg/kg daily; rate of 0.5 μl per hour) or saline for a period of 14-days via osmotic minipumps. Chronic nicotine administration induced a marked region-specific upregulation of the oxytocin receptor binding in the amygdala, a brain region involved in stress and emotional regulation. These results provide direct evidence for nicotine-induced neuroadaptations in the oxytocinergic system, which may be involved in the modulation of nicotine-seeking as well as emotional consequence of chronic drug use. PMID:26037668

  7. Education Department General Administrative Regulations. 34 CFR Parts 74, 75, 76, 77, 79, 80, 81, 82, 85, 86, 97, 98, and 99.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    This publication by the U.S. Department of Education is an unofficial version of the Department's General Administrative Regulations. The volume incorporates final regulations that the Department published too late to appear in the official July 1, 1998, version of Title 34 of the Code of Federal Regulations issued by the Office of the Federal…

  8. US Food and Drug Administration regulations governing label claims for food products, including probiotics.

    PubMed

    Saldanha, Leila G

    2008-02-01

    The US Congress has granted the Food and Drug Administration the authority to permit manufacturers to use claims in food labels that fit into the following broad categories: health claims, structure/function claims, nutrient content claims, and dietary guidance messages. This article outlines the scope and evolution of these claims and how they are used in the marketing of probiotics. Probiotics are live microorganisms (in most cases, bacteria) that are similar to beneficial microorganisms found in the human gut.

  9. 75 FR 22819 - Considerations Regarding Food and Drug Administration Review and Regulation of Articles for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... and Regulation of Articles for the Treatment of Rare Diseases; Public Hearing AGENCY: Food and Drug... by which FDA considers articles for people with rare diseases, a recent public law (Agriculture..., marketing authorization for, and postmarket surveillance of, articles for rare diseases. The scope of...

  10. 15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., minerals, food additives and dietary supplements, and bottled water. These items do not fall within the... Regulations (EAR). In this part, references to the EAR are references to 15 CFR chapter VII, subchapter C... applications to export and reexport items on the U.S. Munitions List. (See 22 CFR parts 120 through 130.)...

  11. 15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., minerals, food additives and dietary supplements, and bottled water. These items do not fall within the... Regulations (EAR). In this part, references to the EAR are references to 15 CFR chapter VII, subchapter C... items on the U.S. Munitions List. (See 22 CFR parts 120 through 130.) Dual use. Items that have...

  12. 15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., minerals, food additives and dietary supplements, and bottled water. These items do not fall within the... Regulations (EAR). In this part, references to the EAR are references to 15 CFR chapter VII, subchapter C..., responsible for reviewing applications to export and reexport items on the U.S. Munitions List. (See 22...

  13. 15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., minerals, food additives and dietary supplements, and bottled water. These items do not fall within the... Regulations (EAR). In this part, references to the EAR are references to 15 CFR chapter VII, subchapter C... items on the U.S. Munitions List. (See 22 CFR parts 120 through 130.) Dual use. Items that have...

  14. 20 CFR 672.500 - What administrative regulations apply to the YouthBuild program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... requirements found in 20 CFR part 667, except those that apply only to the WIA Title I-B program and those that... grants requirements: Circular A-110 (codified at 2 CFR part 215), and Circular A-102 at 29 CFR parts 95 and 97, as applicable; (2) The Department's regulations at 29 CFR part 37, which implement...

  15. 20 CFR 672.500 - What administrative regulations apply to the YouthBuild program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... requirements found in 20 CFR part 667, except those that apply only to the WIA Title I-B program and those that... grants requirements: Circular A-110 (codified at 2 CFR part 215), and Circular A-102 at 29 CFR parts 95 and 97, as applicable; (2) The Department's regulations at 29 CFR part 37, which implement...

  16. 20 CFR 672.500 - What administrative regulations apply to the YouthBuild program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... requirements found in 20 CFR part 667, except those that apply only to the WIA Title I-B program and those that... grants requirements: Circular A-110 (codified at 2 CFR part 215), and Circular A-102 at 29 CFR parts 95 and 97, as applicable; (2) The Department's regulations at 29 CFR part 37, which implement...

  17. 75 FR 53864 - Updated Statements of Legal Authority for the Export Administration Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ..., Inventions and patents, Research, Science and technology. 15 CFR Parts 736, 738, 770, and 772 Exports. 15 CFR... Regarding Export Control Regulations (74 FR 50681, August 16, 2010), which is the most recent such annual... recordkeeping requirements, Science and technology. 0 Accordingly, parts 730, 732, 734, 736, 738, 740, 742,...

  18. 76 FR 58393 - Updated Statements of Legal Authority for the Export Administration Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... procedure, Exports, Inventions and patents, Research, Science and technology. 15 CFR Parts 736, 738, 770... notice of August 12, 2011--Continuation of Emergency Regarding Export Control Regulations (76 FR 50661... procedure, Exports, Reporting and recordkeeping requirements, Science and technology. Accordingly, parts...

  19. Administrative Action to End Discrimination Based on Handicap: HEW's Section 504 Regulation.

    ERIC Educational Resources Information Center

    Engebretson, Mark F.

    1979-01-01

    Examines the drafting of regulations under Section 504 of the Rehabilitation Act of 1973, which prohibits discrimination against handicapped persons by recipients of federal funds. Available from Harvard Legislative Research Bureau, Langdell Hall, Harvard Law School, Cambridge, MA 02138; single copy $4.00. (Author/IRT)

  20. 77 FR 73289 - Hazardous Substances and Articles; Administration and Enforcement Regulations: Revisions to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-10

    ... rulemaking to amend and to update regulations on the CPSC's animal testing methods under the FHSA. 77 FR... ) approved by the Commission. 77 FR 38751. The proposed codification at 16 CFR 1500.232 would make the ICCVAM... FR 38754). We received three comments on the proposed rule. Two of the comments were from...

  1. 76 FR 12563 - Amendments to General Regulations of the Food and Drug Administration; Confirmation of Effective...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... that appeared in the Federal Register of November 30, 2010 (75 FR 73951). The direct final rule amends... (75 FR 73951), FDA solicited comments concerning the direct final rule for a 75-day period ending... authority to regulate these products under the Family Smoking Prevention and Tobacco Control Act,...

  2. 78 FR 69543 - Amendments to General Regulations of the Food and Drug Administration; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... Federal Register of November 30, 2010 (75 FR 73951), we amended certain regulations in part 1 (21 CFR part... products under the Tobacco Control Act (75 FR 73951 at 73952). However, the revisions inadvertently created... to section 302 of the Federal Food, Drug, and Cosmetic Act (FD&C Act) (21 U.S.C. 332); Revised Sec....

  3. 78 FR 61743 - Revisions to the Export Administration Regulations: Initial Implementation of Export Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-03

    ... October 3, 2013 Part VII Department of Commerce Bureau of Industry and Security 15 CFR Parts 730, 732, 734... / Rules and Regulations#0;#0; ] DEPARTMENT OF COMMERCE Bureau of Industry and Security 15 CFR Parts 730... Reform; Correction AGENCY: Bureau of Industry and Security, Commerce. ACTION: Final rule;...

  4. 77 FR 74631 - General Services Administration Acquisition Regulation: Modifications (Multiple Award Schedules...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... (Multiple Award Schedules); Information Collection AGENCY: Office of Acquisition Policy, General Services... Modifications (Multiple Award Schedule). DATES: Submit comments on or before: February 15, 2013. FOR FURTHER... Acquisition Regulation (GSAR) to add clause 552.243-72; Modifications (Multiple Award Schedules). Under...

  5. 77 FR 56766 - Updated Statements of Legal Authority for the Export Administration Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... 746 of the EAR with respect to Syria is based in part on Executive Order 13338, 69 FR 26751, 3 CFR... August 15, 2012--Continuation of Emergency Regarding Export Control Regulations, 77 FR 49699 (August 16... Actions of the Government of Syria, 77 FR 27559 (May 10, 2012), which is the most recent such...

  6. 76 FR 6149 - Federal Housing Administration (FHA): Temporary Exemption From Compliance With FHA's Regulation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... provided in the May 21, 2010 (75 FR 28632), that led to HUD's decision to issue the waiver. Section 203.37a... include, for example, sales by HUD of real estate-owned (REO) properties under HUD's regulations in 24 CFR... for Housing--Federal Housing Commissioner. Appendix Assessment of Exemption From Compliance With...

  7. 15 CFR 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations (EAR). In this part, references to the EAR are references to 15 CFR chapter VII, subchapter C... magnetometers) together with software that permit reduction of rigid body rotation noise of the platform... items on the U.S. Munitions List. (See 22 CFR parts 120 through 130.) Dual use. Items that have...

  8. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 3

    NASA Technical Reports Server (NTRS)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing.

  9. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 2

    NASA Technical Reports Server (NTRS)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing.

  10. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 1

    NASA Technical Reports Server (NTRS)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA conference on Fibrous Composites in structural Design. Presentations were made in the following areas of composite structural design: perspectives in composites; design methodology; design applications; design criteria; supporting technology; damage tolerance; and manufacturing.

  11. The genomic organization of the Fanconi anemia group A (FAA) gene

    SciTech Connect

    Ianzano, L.; Centra, M.; Savino, M.

    1997-05-01

    Fanconi anemia (FA) is a genetically heterogeneous disease involving at least five genes on the basis of complementation analysis (FAA to FAE). The FAA gene has been recently isolated by two independent approaches, positional and functional cloning. In the present study we describe the genomic structure of the FAA gene. The gene contains 43 exons spanning approximately 80 kb as determined by the alignment of four cosmids and the fine localization of the first and the last exons in restriction fragments of these clones. Exons range from 34 to 188 bp. All but three of the splice sites were consistent with the ag-gt rule. We also describe three alternative splicing events in cDNA clones that result in the loss of exon 37, a 23-bp deletion at the 5{prime} end of exon 41. Sequence analysis of the 5{prime} region upstream of the putative transcription start site showed no obvious TATA and CAAT boxes, but did show a GC-rich region, typical of housekeeping genes. Knowledge of the structure of the FAA gene will provide an invaluable resource for the discovery of mutations in the gene that accounts for about 60-66% of FA patients. 24 refs., 3 figs., 1 tab.

  12. Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.

    PubMed

    Cho, Jin Hee; Cho, Yun Ha; Kim, Hyo Young; Cha, Seung Ha; Ryu, Hyun; Jang, Wooyoung; Shin, Kyung Ho

    2015-04-01

    Caffeine produces a variety of behavioral effects including increased alertness, reduced food intake, anxiogenic effects, and dependence upon repeated exposure. Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine. Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum. However, it is not clear whether acute caffeine administration alters CART in other areas of the brain. To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice. We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas. In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg. This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration.

  13. Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.

    PubMed

    Cho, Jin Hee; Cho, Yun Ha; Kim, Hyo Young; Cha, Seung Ha; Ryu, Hyun; Jang, Wooyoung; Shin, Kyung Ho

    2015-04-01

    Caffeine produces a variety of behavioral effects including increased alertness, reduced food intake, anxiogenic effects, and dependence upon repeated exposure. Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine. Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum. However, it is not clear whether acute caffeine administration alters CART in other areas of the brain. To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice. We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas. In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg. This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration. PMID:25820086

  14. Regulation of skeletal muscle protein degradation and synthesis by oral administration of lysine in rats.

    PubMed

    Sato, Tomonori; Ito, Yoshiaki; Nagasawa, Takashi

    2013-01-01

    Several catabolic diseases and unloading induce muscle mass wasting, which causes severe pathological progression in various diseases and aging. Leucine is known to attenuate muscle loss via stimulation of protein synthesis and suppression of protein degradation in skeletal muscle. The aim of this study was to investigate the effects of lysine intake on protein degradation and synthesis in skeletal muscle. Fasted rats were administered 22.8-570 mg Lys/100 g body weight and the rates of myofibrillar protein degradation were assessed for 0-6 h after Lys administration. The rates of myofibrillar protein degradation evaluated by MeHis release from the isolated muscles were markedly suppressed after administration of 114 mg Lys/100 g body weight and of 570 mg Lys/100 g body weight. LC3-II, a marker of the autophagic-lysosomal pathway, tended to decrease (p=0.05, 0.08) after Lys intake (114 mg/100 g body weight). However, expression of ubiquitin ligase E3 atrogin-1 mRNA and levels of ubiquitinated proteins were not suppressed by Lys intake. Phosphorylation levels of mTOR, S6K1 and 4E-BP1 in the gastrocnemius muscle were not altered after Lys intake. These results suggest that Lys is able to suppress myofibrillar protein degradation at least partially through the autophagic-lysosomal pathway, not the ubiquitin-proteasomal pathway, whereas Lys might be unable to stimulate protein synthesis within this time frame. PMID:24418875

  15. Regulation of skeletal muscle protein degradation and synthesis by oral administration of lysine in rats.

    PubMed

    Sato, Tomonori; Ito, Yoshiaki; Nagasawa, Takashi

    2013-01-01

    Several catabolic diseases and unloading induce muscle mass wasting, which causes severe pathological progression in various diseases and aging. Leucine is known to attenuate muscle loss via stimulation of protein synthesis and suppression of protein degradation in skeletal muscle. The aim of this study was to investigate the effects of lysine intake on protein degradation and synthesis in skeletal muscle. Fasted rats were administered 22.8-570 mg Lys/100 g body weight and the rates of myofibrillar protein degradation were assessed for 0-6 h after Lys administration. The rates of myofibrillar protein degradation evaluated by MeHis release from the isolated muscles were markedly suppressed after administration of 114 mg Lys/100 g body weight and of 570 mg Lys/100 g body weight. LC3-II, a marker of the autophagic-lysosomal pathway, tended to decrease (p=0.05, 0.08) after Lys intake (114 mg/100 g body weight). However, expression of ubiquitin ligase E3 atrogin-1 mRNA and levels of ubiquitinated proteins were not suppressed by Lys intake. Phosphorylation levels of mTOR, S6K1 and 4E-BP1 in the gastrocnemius muscle were not altered after Lys intake. These results suggest that Lys is able to suppress myofibrillar protein degradation at least partially through the autophagic-lysosomal pathway, not the ubiquitin-proteasomal pathway, whereas Lys might be unable to stimulate protein synthesis within this time frame.

  16. 76 FR 77115 - Amendments to the Export Administration Regulations: Facilitating Enhanced Public Understanding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... that of August 12, 2011 (76 FR 50,661 (Aug. 16, 2011)), has continued the Regulations in effect under.... 13026, 61 FR 58767, 3 CFR, 1996 Comp., p. 228; E.O. 13222, 66 FR 44025, 3 CFR, 2001 Comp., p. 783; Notice of August 12, 2011 (76 FR 50661 (Aug. 16, 2011)). Sec. 732.1 0 2. Section 732.1 is amended by: 0...

  17. 49 CFR 23.45 - What are the requirements for submitting overall goal information to the FAA?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... you concluded your goals were appropriate. This means that you must provide to the FAA the data, calculations, assumptions, and reasoning used in establishing your goals. (f) Your submission must include your...-conscious means, respectively, and the basis for making this projection (see § 23.51(d)(5)) (g) FAA...

  18. Melatonin administration in diabetes: regulation of plasma Cr, V, and Mg in young male Zucker diabetic fatty rats.

    PubMed

    Navarro-Alarcon, Miguel; Ruiz-Ojeda, Francisco J; Blanca-Herrera, Rosa M; Kaki, Abdullah; Adem, Abdu; Agil, Ahmad

    2014-03-01

    The use of melatonin, a neurohormone present in plants, represents an exciting approach for the maintenance of optimum health conditions. Melatonin administration ameliorates glucose homeostasis in Zucker diabetic fatty (ZDF) rats. The objective of this study was to investigate the effects of melatonin in diabetes in relation to the levels and regulation of plasma chromium (Cr), vanadium (V), and magnesium (Mg) in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. At the age of 6 weeks, ZDF (n = 30) and ZL (n = 30) groups were each subdivided into three groups: control (C) (n = 10), vehicle-treated (V') (n = 10) and melatonin-treated (M) (10 mg kg(-1) per day; n = 10) groups for a 6 week period. After treatment, plasma mineral concentrations were measured by flame (Mg) and electrothermal (Cr and V) atomic absorption spectrometry. No significant differences were found between the C and V' groups (p > 0.05). Plasma Mg levels were significantly lower in C-ZDF vs. C-ZL rats, demonstrating the presence of hypomagnesemia in this diabetes mellitus model. Plasma V and Cr levels were significantly higher in M-ZDF vs. C-ZDF rats. Plasma Mg levels in ZDF rats were not affected by melatonin treatment (p > 0.05). Melatonin administration ameliorates the diabetic status of ZDF rats by enhancing plasma Cr and V concentrations. This appears to be the first report of a beneficial effect of melatonin treatment on plasma Cr and V regulation in ZDF rats.

  19. NASA/FAA/NCAR Supercooled Large Droplet Icing Flight Research: Summary of Winter 1996-1997 Flight Operations

    NASA Technical Reports Server (NTRS)

    Miller, Dean; Ratvasky, Thomas; Bernstein, Ben; McDonough, Frank; Strapp, J. Walter

    1998-01-01

    During the winter of 1996-1997, a flight research program was conducted at the NASA-Lewis Research Center to study the characteristics of Supercooled Large Droplets (SLD) within the Great Lakes region. This flight program was a joint effort between the National Aeronautics and Space Administration (NASA), the National Center for Atmospheric Research (NCAR), and the Federal Aviation Administration (FAA). Based on weather forecasts and real-time in-flight guidance provided by NCAR, the NASA-Lewis Icing Research Aircraft was flown to locations where conditions were believed to be conducive to the formation of Supercooled Large Droplets aloft. Onboard instrumentation was then used to record meteorological, ice accretion, and aero-performance characteristics encountered during the flight. A total of 29 icing research flights were conducted, during which "conventional" small droplet icing, SLD, and mixed phase conditions were encountered aloft. This paper will describe how flight operations were conducted, provide an operational summary of the flights, present selected experimental results from one typical research flight, and conclude with practical "lessons learned" from this first year of operation.

  20. The institutionalization of pharmaceutical administration after the korean liberation: focusing on regulating the pharmaceutical affairs law(yaksabeop) in 1953.

    PubMed

    Sihn, Kyu-Hwan

    2013-12-01

    The pharmaceutical administration under U.S Military Government in Korea and government of the Republic of Korea aimed at cleaning up the vestiges of Japanese imperialism which the pharmaceutical administration attached police administration and preparing with legal and systemic basis after the Korean liberation. The pharmaceutical bureau under U.S Military Government in Korea was reorganized as the independent division. The pharmaceutical bureau focused on preserving order, narcotics control and the distribution of relief drug. U.S Military Government proceeded supply side pharmaceutical policy for the distribution of relief drug without constructing human and material infrastructure. After the Korean War, Korean society asked the construction of system for nation building. Korean national assembly regulated National Medical Law(Gukmin uiryobeop) for promotion of public health in 1951. The Pharmaceutical Affairs Law(Yaksabeop) was regulated in 1953, and it prescribed the job requirement of pharmacist, apothecary, and drug maker and seller, and presented the frame of managing medical supplies. The Pharmaceutical Law originally planned the ideal pharmaceutical administration, but it rather secured the status of traditional apothecary, and drug maker and seller. On the contrary, though the Pharmaceutical Law guaranteed the traditional druggists, it did not materialize reproduction system such as educational and license system. It means that the traditional druggists would be degenerated in the near future. After the armistice agreement in 1953, Korean was in medical difficulties. Korean government was suffered from the deficiency of medical resources. Because of destruction of pharmaceutical facilities, Korean had to depend on United States and international aid. The Pharmaceutical Affairs Law did not cleaned up the vestiges of Japanese imperialism, and compromised with reality lacked human and material infrastructure. As a result, the law became the origin of

  1. Employee Retirement Income Security Act of 1974; rules and regulations for administration and enforcement; claims procedure. Final regulation; delay of applicability date.

    PubMed

    2001-07-01

    This action delays for at least six months and not more than one year the applicability date for the regulation governing minimum requirements for benefit claims procedures of group health plans covered by Title I of the Employee Retirement Income Security Act. As published on November 21, 2000, the benefit claims procedure would be applicable to claims filed on or after January 1, 2002. The current action amends the regulation so that it will apply to group health claims filed on or after the first day of the first plan year beginning on or after July 1, 2002, but in no event later than January 1, 2003. This action provides a limited additional period within which group health plan sponsors, administrators, and service providers can bring their claims processing systems into compliance with the new requirements. A postponement of the applicability date with respect to group health claims will allow a more orderly transition to the new standards and will avoid the confusion and additional expense that would be caused if certain pending Congressional bills are enacted before or soon after the original applicability date. This action does not apply to pension plans or plans providing disability or welfare benefits (other than group health). For these plans, the regulation will continue to be applicable to claims filed on or after January 1, 2002.

  2. Voglibose administration regulates body weight and energy intake in high fat-induced obese mice.

    PubMed

    Do, Hyun Ju; Jin, Taeon; Chung, Ji Hyung; Hwang, Ji Won; Shin, Min-Jeong

    2014-01-17

    We tested whether long-term administration of voglibose (VO) prevents diet induced obesity in addition to hypoglycemic effects in high fat fed mice and further investigated the underlying mechanisms by which voglibose exerts its weight lowering effect. Male C57BL/6 mice were fed ad libitum for 12 weeks with the control diet (CTL), high-fat diet (HFD) or the HFD with VO supplementations. Blood lipid profile, plasma leptin levels and hepatic triglyceride content, as well as expressions of genes involved in appetite and mitochondrial function were examined. The results showed that VO significantly reduced body weight, fat mass and energy intakes in high fat fed mice. VO showed improved metabolic profiles including blood glucose, triglyceride and free fatty acid. Elevated levels of plasma leptin in HFD were significantly reduced with the VO, furthermore, VO modulated the hypothalamic expressions of leptin receptors and appetite related genes. VO showed the upregulated expressions of PGC-1 in the liver and epididymal adipose tissue. In conclusion, VO may exert antiobesity properties through reductions in energy intake and improvement in mitochondrial function, indicating that VO has potential therapeutic use in patients with obesity, type 2 diabetes, and related complications.

  3. Regulated hypothermia in the hypothyroid rat induced by administration of propylthiouracil.

    PubMed

    Yang, Y; Gordon, C J

    1997-05-01

    Propylthiouracil (PTU), an antithyroidal drug that reduces serum L-thyroxine (T4) and 3,5,3'-triiodothyronine (T3), is presumed to lower core temperature (T0) by impairing metabolic thermogenesis. However, it is not understood why PTU-treated animals cannot use behavioral and other thermoeffectors to maintain normal Tc. Male rats were administered PTU in drinking water (0.05 mg/ml) while the following parameters were measured: 1) Tc and motor activity (MA) recorded by radiotelemetry for 24 h at ambient temperatures (Ta) of 10-30 degrees C; 2) selected Ta, MA, and Tc in a temperature gradient; and 3) Tc, MA, and grooming behavior during exposure to heat stress (TH = 34.5 degrees C) for 2 h. PTU reduced serum levels of T4, and T3 by 95 and 60%, respectively. Tc decreased after 3 days of PTU treatment; a 0.5 degree C decrease in Tc persisted throughout the PTU treatment. PTU rats exposed to Ta of 10-30 degrees C maintained a consistent hypothermic Tc during the light phase; however, a deficit in the stability of Tc at night was noted during exposure to 10 degrees C. In the temperature gradient, PTU rats selected warmer Ta, but their Tc was maintained at the same hypothermic levels as observed at fixed Ta values of 15-30 degrees C. Heat stress caused Tc of control rats to increase to 39 degrees C, whereas Tc of the PTU rats was maintained below 38 degrees C. The regulation of Tc at hypothermic levels over a wide range of Ta values and when rats were housed in a temperature gradient indicates that chronic PTU induces a state of regulated hypothermia. PMID:9176328

  4. Restoring Equal Opportunity in Education: An Analysis of Arguments for and against the Bush Administration Single-Sex Education Regulations. Briefing Paper #C368

    ERIC Educational Resources Information Center

    English, Ashley

    2009-01-01

    In 2006, the George W. Bush Administration issued new Title IX regulations that allow for sex-segregated classrooms and schools in public, non-vocational elementary and secondary schools. These regulations provide schools with another condition that allows them to provide sex-segregated programs as long as they meet an "important governmental…

  5. Agenda-building influences on the news media's coverage of the U.S. Food and Drug Administration's push to regulate tobacco, 1993-2009.

    PubMed

    Foster, Caroline; Thrasher, Jim; Kim, Sei-Hill; Rose, India; Besley, John; Navarro, Ashley

    2012-01-01

    Citing agenda-building theory, this article examines the influence of three key factors on the news media's coverage of the process of placing tobacco and tobacco products under regulation of the U.S. Food and Drug Administration between 1993 and 2009. We analyzed data from a content analysis of 570 news articles from The New York Times and Washington Post and found that the media published significantly more FDA regulation articles during the Clinton administration than during the Bush administration. Our analysis links that imbalance of media coverage to the influence of the president of the United States (Clinton and Bush, during the duration of this study), journalistic routines and real world events. We compared the Clinton and Bush era news coverage on article prominence, article topics, and reasons to support/oppose FDA regulation and found significant differences, which we suggest led to the imbalance of news articles in the two administrations. PMID:23293806

  6. Extraction of nickel from edible oils with a complexing agent prior to determination by FAAS.

    PubMed

    Tokay, Feyzullah; Bağdat, Sema

    2016-04-15

    In the present work, a new extraction method for separation of nickel from edible oils and determination by FAAS is reported. This method is based on extraction of Ni(II) ions from the oil to aqueous phase with N,N'-bis(4-methoxysalicylidene) ethylenediamine (MSE) and determination by FAAS. Properties of the complex formed between MSE and Ni(II) were investigated spectrophotometrically. Central composite design (CCD) was utilized for optimization of MSE to oil, stirring time and temperature, which were 0.97 mL g(-1), 15.4 min, and 29.7°C, respectively. The developed method was tested with an oil-based metal standard and the recovery was 93.8±3.9%. The proposed method was applied with five different edible oils. PMID:26616973

  7. Proceedings of the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. Volume 1

    NASA Technical Reports Server (NTRS)

    Bigelow, Catherine A. (Compiler)

    1997-01-01

    This publication contains the fifty-two technical papers presented at the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. The symposium, hosted by the FAA Center of Excellence for Computational Modeling of Aircraft Structures at Georgia Institute of Technology, was held to disseminate information on recent developments in advanced technologies to extend the life of high-time aircraft and design longer-life aircraft. Affiliations of the participants included 33% from government agencies and laboratories, 19% from academia, and 48% from industry; in all 240 people were in attendance. Technical papers were selected for presentation at the symposium, after a review of extended abstracts received by the Organizing Committee from a general call for papers.

  8. New method for speciation analysis of aluminium fluoride complexes by HPLC-FAAS hyphenated technique.

    PubMed

    Frankowski, M; Zioła-Frankowska, A; Siepak, J

    2010-03-15

    Speciation analysis of aluminium in the presented system of HPLC-FAAS hyphenated technique lasts 4min. Using the bifunctional column in model analysis and using the calculation methods for modelling using the Mineql program enabled the authors to presume that particular forms will be subjected to elution in the following order: (1) AlF(2)(+) and AlF(4)(-), (2) AlF(2+) and AlF(3)(0) and (3) Al(3+). Based on the obtained results for model solutions, the presented method enables the determination of aluminium fluoride complexes and Al(3+) speciation form. The study compares the tendency of occurrence variability of aluminium fluoride complexes and Al(3+) form, determined based on the results obtained using the HPLC-FAAS hyphenated technique with the trend defined based on the Mineql program calculation method. The method was successfully applied to soil samples. PMID:20152461

  9. Proceedings of the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. Volume 2

    NASA Technical Reports Server (NTRS)

    Bigelow, Catherine A. (Compiler)

    1997-01-01

    This publication contains the fifty-two technical papers presented at the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. The symposium, hosted by the FAA Center of Excellence for Computational Modeling of Aircraft Structures at Georgia Institute of Technology, was held to disseminate information on recent developments in advanced technologies to extend the life of high-time aircraft and design longer-life aircraft. Affiliations of the participants included 33% from government agencies and laboratories, 19% from academia, and 48% from industry; in all 240 people were in attendance. Technical papers were selected for presentation at the symposium, after a review of extended abstracts received by the Organizing Committee from a general call for papers.

  10. CB1 Receptors Regulate Alcohol-Seeking Behavior and Alcohol Self-administration of Female Alcohol-Preferring (P) Rats

    PubMed Central

    Getachew, Bruk; Hauser, Sheketha R.; Dhaher, Ronnie; Bell, Richard L.; Oster, Scott M.; McBride, William J.; Rodd, Zachary A.

    2015-01-01

    Rationale The endogenous cannabinoid (CB) system mediates a number of behaviors associated with drug-seeking and drug self-administration. In this study the effects of CB1 receptor manipulations on operant ethanol (EtOH) responding during EtOH-seeking, EtOH- relapse as well as on-going EtOH self-administration were determined. Methods Alcohol-preferring (P) rats were trained in 2-lever operant chambers to self-administer 15% EtOH (v/v) and water on a concurrent fixed-ratio 5 – fixed-ratio 1 (FR5-FR1) schedule of reinforcement in daily 1-hr sessions. After 10 weeks, rats underwent 7 extinction sessions, followed by 2 weeks in their home cages without access to EtOH or operant chambers. Rats were then returned to the operant chambers for testing of EtOH-seeking behavior (no EtOH present) for 4 sessions. After a week in their home cages following the EtOH-seeking test, rats were returned to the operant chambers with access to EtOH and water (relapse). Rats were then maintained in the operant chambers for daily 1-hr sessions with access to 15% EtOH and water for several weeks. Results The CB1 receptor antagonist (SR141716A), at doses of 1 and 2 mg/kg, i.p. reduced EtOH-seeking and transiently reduced EtOH self-administration during relapse and maintenance. Conversely, treatment with the CB1 receptor agonist CP, 55-940, at doses of 1 and 10 μg/kg i.p., increased EtOH-seeking and EtOH self-administration during relapse. Conclusions The results of this study demonstrate that activation of CB1 receptors are involved in regulating EtOH-seeking as well as the reinforcing effects of EtOH under relapse and on-going self-administration conditions. PMID:21110997

  11. NextGen Technologies on the FAA's Standard Terminal Automation Replacement System

    NASA Technical Reports Server (NTRS)

    Witzberger, Kevin; Swenson, Harry; Martin, Lynne; Lin, Melody; Cheng, Jinn-Hwei

    2014-01-01

    This paper describes the integration, evaluation, and results from a high-fidelity human-in-the-loop (HITL) simulation of key NASA Air Traffic Management Technology Demonstration - 1 (ATD- 1) technologies implemented in an enhanced version of the FAA's Standard Terminal Automation Replacement System (STARS) platform. These ATD-1 technologies include: (1) a NASA enhanced version of the FAA's Time-Based Flow Management, (2) a NASA ground-based automation technology known as controller-managed spacing (CMS), and (3) a NASA advanced avionics airborne technology known as flight-deck interval management (FIM). These ATD-1 technologies have been extensively tested in large-scale HITL simulations using general-purpose workstations to study air transportation technologies. These general purpose workstations perform multiple functions and are collectively referred to as the Multi-Aircraft Control System (MACS). Researchers at NASA Ames Research Center and Raytheon collaborated to augment the STARS platform by including CMS and FIM advisory tools to validate the feasibility of integrating these automation enhancements into the current FAA automation infrastructure. NASA Ames acquired three STARS terminal controller workstations, and then integrated the ATD-1 technologies. HITL simulations were conducted to evaluate the ATD-1 technologies when using the STARS platform. These results were compared with the results obtained when the ATD-1 technologies were tested in the MACS environment. Results collected from the numerical data show acceptably minor differences, and, together with the subjective controller questionnaires showing a trend towards preferring STARS, validate the ATD-1/STARS integration.

  12. Survey: Federal Aviation Administration National Communication Center

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The National Communication (NATCOM) Center (commonly known as the FAA Weather Message Switching Center), is a Federal Aviation Administration (FAA) facility with responsibility for providing communication switching services to the National Weather Service (NWS), the FAA, commercial and private flight organizations under the auspices of the FAA, and DoD. Data handled by NATCOM include weather data, flight plans, and Notices to Airmen (NOTAMS) on both national and international networks. The communications and data management functions are handled through four computer-controlled communication networks designated as WMSC, AFTN, A-BDIS, and NASNET. The functions of these networks are discussed with emphasis on those networks that support the different elements of the NWS. The primary network of concern to NASA, the WMSC (Weather Message Switching Center) network, performs approximately 60 percent of its work for the NWS, 20 percent for the State Department, and 20 percent for the FAA. This document discusses the current and future systems capabilities and workload of NATCOM in terms of new roles.

  13. Gonadal and pituitary responsiveness of stallions is not down-regulated by prolonged pulsatile administration of GnRH.

    PubMed

    Brinsko, S P; Squires, E L; Pickett, B W; Nett, T M

    1998-01-01

    The objective of this study was to determine if prolonged pulsatile administration of homologous gonadotropin-releasing hormone (GnRH) at therapeutic or 5x therapeutic doses would cause down-regulation of the stallion's hypothalamic-pituitary-testicular axis. Fifteen stallions were randomly assigned to three treatment groups (n=5/group) and received a 0.5 ml subcutaneous dose of saline (group 1), 50 microg GnRH (group 2), or 250 microg GnRH (group 3) every 2 hours for 75 days. Weekly evaluations of follicle stimulating hormone, luteinizing hormone, and testosterone and monthly evaluations of daily sperm output and spermatozoal motility failed to demonstrate any decreased pituitary or gonadal responsiveness within or among treatment groups (P > 0.1) as a result of treatment with GnRH. Results of this study demonstrate that the hypothalamic-pituitary-testicularaxis of the stallion, unlike that of other domestic species, is remarkably refractory to GnRH-induced down-regulation.

  14. Federal Aviation Administration Curriculum Guide for Aviation Magnet Schools Programs.

    ERIC Educational Resources Information Center

    Strickler, Mervin K., Jr.

    The Federal Aviation Administration (FAA) and its predecessor organizations, Civil Aeronautics Agency (CAA) and the Civil Aeronautics Administration (CAA) have pioneered the use of aviation education in working with schools and colleges of the nation to attain their objectives. This publication includes: a brief history of the role of aviation in…

  15. Factors Contributing to Financial Aid Administrators' Job Satisfaction: NASFAA 2008 Financial Aid Administrators' Job Satisfaction Survey Results

    ERIC Educational Resources Information Center

    National Association of Student Financial Aid Administrators (NJ1), 2008

    2008-01-01

    In what kind of job environment are financial aid administrators (FAA) currently working? How satisfied are they with their jobs? What motivates them and what factors are considered morale dampers? How are financial aid (FA) functions viewed by campus' top administrators? Does FA get similar respect and appreciation from their campus peer offices…

  16. Differential regulation of MeCP2 and PP1 in passive or voluntary administration of cocaine or food.

    PubMed

    Bodetto, Sarah Pol; Romieu, Pascal; Sartori, Maxime; Tesone-Coelho, Carolina; Majchrzak, Monique; Barbelivien, Alexandra; Zwiller, Jean; Anglard, Patrick

    2014-12-01

    Cocaine exposure induces changes in the expression of numerous genes, in part through epigenetic modifications. We have initially shown that cocaine increases the expression of the chromatin remodeling protein methyl-CpG binding protein 2 (MeCP2) and characterized the protein phosphatase-1Cβ (PP1Cβ) gene, as repressed by passive i.p. cocaine injections through a Mecp2-mediated mechanism involving de novo DNA methylation. Both proteins being involved in learning and memory processes, we investigated whether voluntary cocaine administration would similarly affect their expression using an operant self-administration paradigm. Passive and voluntary i.v. cocaine intake was found to induce Mecp2 and to repress PP1Cβ in the prefrontal cortex and the caudate putamen. This observation is consistent with the role of Mecp2 acting as a transcriptional repressor of PP1Cβ and shows that passive intake was sufficient to alter their expression. Surprisingly, striking differences were observed under the same conditions in food-restricted rats tested for food pellet delivery. In the prefrontal cortex and throughout the striatum, both proteins were induced by food operant conditioning, but remained unaffected by passive food delivery. Although cocaine and food activate a common reward circuit, changes observed in the expression of other genes such as reelin and GAD67 provide new insights into molecular mechanisms differentiating neuroadaptations triggered by each reinforcer. The identification of hitherto unknown genes differentially regulated by drugs of abuse and a natural reinforcer should improve our understanding of how two rewarding stimuli differ in their ability to drive behavior.

  17. Regulation of feeding behavior and plasma testosterone in response to central neuropeptide Y administration in a songbird.

    PubMed

    Davies, Scott; Deviche, Pierre

    2015-08-01

    In mammalian and avian model species, neuropeptide Y (NPY) simultaneously promotes feeding behavior and suppresses the secretion of reproductive hormones, thereby modulating the resource allocation trade-off between investing in essential somatic processes or in the reproductive system. Investigations into this dual role of NPY in birds have focused on domesticated species and, to our knowledge, no study has examined this role in songbirds. We determined whether NPY treatment acutely regulates feeding behavior and activity of the reproductive system in a male songbird, the Abert's Towhee, Melozone aberti. Intracerebroventricular (ICV) administration of NPY promoted behaviors associated with feeding (decreased latency to initiate pecking in the food bowl, increased number of feeding bouts following treatment, and increased number of pecks into the food bowl during each feeding bout), and it stimulated hopping and drinking behavior. By contrast, we found no effect of NPY treatment on plasma testosterone secretion 60 min after treatment. These results suggest that in male Abert's Towhees NPY stimulates feeding behavior, but provide no evidence that this peptide concurrently influences testosterone secretion.

  18. The Federal Aviation Administration/Massachusetts Institute of Technology (FAA/MIT) Lincoln Laboratory Doppler weather radar program

    NASA Technical Reports Server (NTRS)

    Evans, James E.

    1988-01-01

    The program focuses on providing real-time information on hazardous aviation weather to end users such as air traffic control and pilots. Existing systems will soon be replaced by a Next Generation Weather Radar (NEXRAD), which will be concerned with detecting such hazards as heavy rain and hail, turbulence, low-altitude wind shear, and mesocyclones and tornadoes. Other systems in process are the Central Weather Processor (CWP), and the terminal Doppler weather radar (TDWR). Weather measurements near Memphis are central to ongoing work, especially in the area of microbursts and wind shear.

  19. Automating test case generation for coverages required by FAA standard DO-178B

    NASA Technical Reports Server (NTRS)

    Voas, Jeffrey M.; Payne, Jeffery E.; Miller, Keith W.

    1993-01-01

    Coverage testing techniques are required by the FAA for various levels of subsystem criticality at the unit testing level. Higher levels of criticality require coverage schemes that frequently require more and more test cases, particularly when the number of conditions in a decision grows. For example, if we have a decision with n conditions of the form: if (/ci/ or /c2/ or .... or /cn/) then there are 2(n) possible combinations of condition outcomes. Given the enormous number of inputs that may be required to satisfy different coverages, and given that there are no automated tools for determining these inputs (to our knowledge), we will show how one alternative testing technique, mutation testing, can be coerced into generating inputs that satisfy a code coverage scheme X, i.e., if we modify the rules for mutant generation during mutation testing, this technique will provide test cases that satisfy X.

  20. An overview of the joint FAA/NASA aircraft/ground runway friction program

    NASA Technical Reports Server (NTRS)

    Yager, Thomas J.

    1989-01-01

    There is a need for information on runways which may become slippery due to various forms and types of contaminants. Experience has shown that since the beginning of all weather aircraft operations, there have been landing and aborted takeoff incidents and/or accidents each year where aircraft have either run off the end or veered off the shoulder of low friction runways. NASA Langley's Landing and Impact Dynamics Branch is involved in several research programs directed towards obtaining a better understanding of how different tire properties interact with varying pavement surface characteristics to produce acceptable performance for aircraft ground handling requirements. One such effort, which was jointly supported by not only NASA and the FAA but by several aviation industry groups including the Flight Safety Foundation, is described.

  1. NASA/FAA Helicopter ATC simulation investigation of RNAV/MLS instrument approaches

    NASA Technical Reports Server (NTRS)

    Peach, L. L., Jr.; Tobias, L.; Lee, H. Q.

    1982-01-01

    The NASA/FAA Helicopter Air Traffic Control (ATC) simulation investigations to determine the feasibility of simultaneous, independent instrument approach procedures for helicopters at major terminal areas, using Area Navigation/Microwave Landing System (RNAV/MLS) guidance, was conducted at several levels of helicopter display sophistication, up to that of a Cockpit Display of Traffic Information (CDTI) system. Test objectives included the determination of pilot acceptability and the tracking performance of the RNAV/MLS's noninterfering rotorcraft approach path structure, along with the evaluation of the effect on controller workload of multiroute structures combining conventional and rotorcraft approaches at various arrival rates and traffic separations. The utility of electronic area maps and CDTI displays was also investigated. Participating pilots flew 127 simulated instrument approaches in an ATC simulation laboratory.

  2. CSLAA and FAA'S Rules: Incorporating a 'Risk Management Framework' to Minimise Human Space Flight Risks

    NASA Astrophysics Data System (ADS)

    Chaddha, S.

    2012-01-01

    th This year marks the 50 anniversary of a landmark victory for humankind in its endeavour of entering and exploring the final frontier. During these years of space activity, we have witnessed a number of cumulative successes. One of which is the emergence of the commercial human space flight, or "space tourism", market. Commercial companies have the aim of travelling people into space safely and affordably. This paper shall consider the U.S. regulatory framework governing the space tourism market. It scrutinises the adequacy of the Commercial Space Launch and Amendment Act of 2004 (CSLAA), as bolstered by the FAA's requirements, to protect launching passengers to an acceptable standard of safety from the inherent risks associated with human space flights. It is argued that the legislative regime embeds a three-limb "risk management framework" as an appropriate response to address the concern over the safety of public space travel.

  3. NASA,FAA,ONERA Swept-Wing Icing and Aerodynamics: Summary of Research and Current Status

    NASA Technical Reports Server (NTRS)

    Broeren, Andy

    2015-01-01

    NASA, FAA, ONERA, and other partner organizations have embarked on a significant, collaborative research effort to address the technical challenges associated with icing on large scale, three-dimensional swept wings. These are extremely complex phenomena important to the design, certification and safe operation of small and large transport aircraft. There is increasing demand to balance trade-offs in aircraft efficiency, cost and noise that tend to compete directly with allowable performance degradations over an increasing range of icing conditions. Computational fluid dynamics codes have reached a level of maturity that they are being proposed by manufacturers for use in certification of aircraft for flight in icing. However, sufficient high-quality data to evaluate their performance on iced swept wings are not currently available in the public domain and significant knowledge gaps remain.

  4. Precision Departure Release Capability (PDRC) Overview and Results: NASA to FAA Research Transition

    NASA Technical Reports Server (NTRS)

    Engelland, Shawn; Davis, Tom.

    2013-01-01

    NASA researchers developed the Precision Departure Release Capability (PDRC) concept to improve the tactical departure scheduling process. The PDRC system is comprised of: 1) a surface automation system that computes ready time predictions and departure runway assignments, 2) an en route scheduling automation tool that uses this information to estimate ascent trajectories to the merge point and computes release times and, 3) an interface that provides two-way communication between the two systems. To minimize technology transfer issues and facilitate its adoption by TMCs and Frontline Managers (FLM), NASA developed the PDRC prototype using the Surface Decision Support System (SDSS) for the Tower surface automation tool, a research version of the FAA TMA (RTMA) for en route automation tool and a digital interface between the two DSTs to facilitate coordination.

  5. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  6. 49 CFR 23.45 - What are the requirements for submitting overall goal information to the FAA?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... goal information to the FAA? 23.45 Section 23.45 Transportation Office of the Secretary of Transportation PARTICIPATION OF DISADVANTAGED BUSINESS ENTERPRISE IN AIRPORT CONCESSIONS Goals, Good Faith Efforts, and Counting § 23.45 What are the requirements for submitting overall goal information to the...

  7. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  8. 78 FR 33146 - Notice of Proposal Policy for Distribution of FAA Data and Information; Extension of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    .... ACTION: Notice for Data and Information Policy; Extension of comment period. SUMMARY: This action extends the comment period set out in the notice concerning data and information policy that was published on May 1, 2013. In that document, the FAA proposed its data and information distribution policy...

  9. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  10. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  11. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  12. 14 CFR 11.89 - How much time do I have to submit comments to FAA on a petition for exemption?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false How much time do I have to submit comments to FAA on a petition for exemption? 11.89 Section 11.89 Aeronautics and Space FEDERAL AVIATION... Petitions for Rulemaking and for Exemption § 11.89 How much time do I have to submit comments to FAA on...

  13. 41 CFR 102-35.5 - What is the scope of the General Services Administration's regulations on the disposal of...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of the Federal Property Management Regulations (FPMR)(41 CFR parts 101-42 and 101-45). With two..., the Northern Mariana Islands, the Federated States of Micronesia, the Marshall Islands, and Palau....

  14. ARRA FEMP Technical Assistance -- Federal Aviation Administration Project 209 -- Control Tower and Support Building, Palm Springs, CA

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-03-31

    This report represents findings of a design review team that evaluated construction documents (at the 100% level) and operating specifications for a new control tower and support building that will be built in Palm Springs, California by the Federal Aviation Administration (FAA). The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for the FAA that would not have otherwise occurred.

  15. Simplified multi-element analysis of ground and instant coffees by ICP-OES and FAAS.

    PubMed

    Szymczycha-Madeja, Anna; Welna, Maja; Pohl, Pawel

    2015-01-01

    A simplified alternative to the wet digestion sample preparation procedure for roasted ground and instant coffees has been developed and validated for the determination of different elements by inductively coupled plasma optical emission spectrometry (ICP-OES) (Al, Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, Zn) and flame atomic absorption spectrometry (FAAS) (Ca, Fe, K, Mg, Na). The proposed procedure, i.e. the ultrasound-assisted solubilisation in aqua regia, is quite fast and simple, requires minimal use of reagents, and demonstrated good analytical performance, i.e. accuracy from -4.7% to 1.9%, precision within 0.5-8.6% and recovery in the range 93.5-103%. Detection limits of elements were from 0.086 ng ml(-1) (Sr) to 40 ng ml(-1) (Fe). A preliminary classification of 18 samples of ground and instant coffees was successfully made based on concentrations of selected elements and using principal component analysis and hierarchic cluster analysis.

  16. Factorial design in the optimization of preconcentration procedure for lead determination by FAAS.

    PubMed

    Soylak, Mustafa; Narin, Ibrahim; Bezerra, Marcos de Almeida; Ferreira, Sérgio Luís Costa

    2005-02-28

    The present paper proposes a preconcentration procedure for lead determination using flame atomic absorption spectrometry (FAAS). It is based on lead(II) ions extraction as brilliant cresyl blue (BCB) complex and its sorption onto Diaion HP-2MG, a methacrylic ester copolymer. The optimization step was carried out using factorial design and the variables studied were pH, shaking time and reagent concentration. In the established experimental conditions, lead can be determinate with a limit of detection of 3.7mugL(-1) lead (N = 20) and a relative standard deviation of 7% for a lead concentration of 100mugL(-1). The accuracy was confirmed by analysis of a certified reference material, the stream sediment furnished by National Research Centre for Certified Reference Materials (NRCCRM), China (GBW 07310). Effect of other ions in the procedure proposed was also studied. The method was applied for lead determination in real samples of water, tea, soil and dust. Tests of addition/recovery in the experiments for lead determination in water samples revealed that the proposed procedure could be applied satisfactorily for analysis of these samples. PMID:18969885

  17. NASA/FAA flight-test investigation of helicopter microwave landing system approaches

    NASA Technical Reports Server (NTRS)

    Peach, I. L., Jr.; Bull, J. S.; Anderson, D. J.; Dugan, D. C.; Ross, V. L.; Hunting, A. W.; Pate, D. P.; Savage, J. C.

    1980-01-01

    The helicopter Microwave Landing System flight-test investigations, conducted by a joint NASA/FAA effort in order to gather statistical data for establishing terminal instrument procedures criteria, and to provide a performance data base for developing advanced MLS guidance concepts, are presented. The specific flight-test objectives were to: (1) develop acceptable angle-only MLS approach profiles; (2) determine tracking errors; (3) determine altitude loss during missed approach; (4) evaluate guidance display sensitivities; and (5) evaluate pilot acceptability. Fourteen pilots flew 140 manual (without stability augmentation) dual-pilot simulated instrument approaches in a UH-1H helicopter. The flight profiles flown included 3-, 6-, and 9-degree glideslope, centerline approaches to decision heights of 50, 100, and 150 ft, respectively. The angular guidance display sensitivities and the data acquisition system are also described. Eight major conclusions are made, and include the following: (1) the use of pitch attitude to control airspeed and collective to control glideslope was the preferred pilot technique for the steep glideslope approaches, and (2) angular guidance deviation indicator sensitivity requirements for helicopter MLS approaches to STOLports and heliports have been found to be significantly different from standard ILS sensitivities.

  18. The individual mandate as healthcare regulation: what the Obama Administration should have said in NFIB v. Sebelius.

    PubMed

    Moncrieff, Abigail R

    2013-01-01

    There was an argument that the Obama Administration's lawyers could have made--but didn't--in defending Obamacare's individual mandate against constitutional attack. That argument would have highlighted the role of comprehensive health insurance in steering individuals' healthcare savings and consumption decisions. Because consumer-directed healthcare, which reaches its apex when individuals self-insure, suffers from several known market failures and because comprehensive health insurance policies play an unusually aggressive regulatory role in attempting to correct those failures, the individual mandate could be seen as an attempt to eliminate inefficiencies in the healthcare market that arise from individual decisions to self-insure. This argument would done a better job than the Obama Administration's of aligning the individual mandate with existing Commerce Clause and Necessary and Proper Clause precedent, and it would have done a better job of addressing the conservative Justices' primary concerns with upholding the mandate. This Article lays out this forgone defense of the individual mandate.

  19. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  20. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  1. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  2. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  3. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  4. Intravenous or intranasal administration of gliadin is able to down-regulate the specific immune response in mice.

    PubMed

    Rossi, M; Maurano, F; Caputo, N; Auricchio, S; Sette, A; Capparelli, R; Troncone, R

    1999-08-01

    The mucosal lesion in coeliac disease (CD) represents an immunologically mediated injury triggered by gliadin and is restricted by a particular assortment of major histocompatibility complex (MHC) class II genes. Therefore, immunomodulatory strategies to tolerize gliadin-specific, class II-restricted T-cell responses could represent an alternative to current treatments of CD, which are based on a gluten-free diet. In this study, BALB/c mice derived from a gluten-free diet colony were tolerized by either intranasal (i.n.) or intravenous (i.v.) administration of single or multiple doses of gliadin. While a single dose failed to induce tolerance, a significant decrease in gliadin-specific T-cell proliferation was detected (P < 0.001) after multiple i.n. or i.v. administrations. No significant difference in antibody titre was detected for antigen-specific immunoglobulin G (IgG) or the IgG1 subclass, but a lower IgG2a-specific titre was observed. Both interferon-gamma (IFN-gamma) and interleukin (IL)-2 expression, measured by enzyme-linked immunosorbent assay (ELISA) and reverse transcription-polymerase chain reaction (RT-PCR), were reduced on antigen administration, both i.v. and i.n. Neither regimen showed a regulatory effect on IL-4 production. As T helper 1 (Th1) cytokines seem to be important in the pathogenesis of CD, our data therefore highlight the potential of i.n. and i.v. routes for the design of useful immunomodulatory strategies for CD.

  5. Up-regulation of 5-HT2B receptor density and receptor-mediated glycogenolysis in mouse astrocytes by long-term fluoxetine administration.

    PubMed

    Kong, Ebenezer K C; Peng, Liang; Chen, Ye; Yu, Albert C H; Hertz, Leif

    2002-02-01

    The effects were studied of short-term (1 week) versus long-term (2-3 weeks) fluoxetine treatment of primary cultures of mouse astrocytes, differentiated by treatment with dibutyryl cyclic AMP. From previous experiments it is known that acute treatment with fluoxetine stimulates glycogenolysis and increases free cytosolic Ca2+ concentration ([Ca2+]i]) in these cultures, whereas short-term (one week) treatment with 10 microM down-regulates the effects on glycogen and [Ca2+]i, when fluoxetine administration is renewed (or when serotonin is administered). Moreover, antagonist studies have shown that these responses are evoked by activation of a 5-HT2, receptor that is different from the 5-HT2A receptor and therefore at that time tentatively were interpreted as being exerted on 5-HT2C receptors. In the present study the cultures were found by RT-PCR to express mRNA for 5-HT2A and 5-HT2B receptors, but not for the 5-HT2C receptor, identifying the 5-HT2 receptor activated by fluoxetine as the 5-HT2B receptor, the most recently cloned 5-Ht2 receptor and a 5-HT receptor known to be more abundant in human, than in rodent, brain. Both short-term and long-term treatment with fluoxetine increased the specific binding of [3H]mesulergine, a ligand for alL three 5-HT2 receptors. Long-term treatment with fluoxetine caused an agonist-induced up-regulation of the glycogenolytic response to renewed administration of fluoxetine, whereas short-term treatment abolished the fluoxetine-induced hydrolysis of glycogen. Thus, during a treatment period similar to that required for fluoxetine's clinical response to occur, 5-HT2B-mediated effects are initially down-regulated and subsequently up-regulated. PMID:11930908

  6. An on-line preconcentration/separation system for the determination of bismuth in environmental samples by FAAS.

    PubMed

    Sahan, Serkan; Saçmaci, Serife; Sahin, Uğur; Ulgen, Ahmet; Kartal, Senol

    2010-03-15

    An on-line preconcentration procedure for the determination of bismuth by flame atomic absorption spectrometry (FAAS) has been described. Lewatit TP-207 chelating resin, including iminodiacetate group, packed in a minicolumn was used as adsorbent material. Bi(III) was sorbed on the chelating resin, from which it could be eluted with 3 mol L(-1) HNO(3) and then introduced directly to the nebulizer-burner system of FAAS. Best preconcentration conditions were established by testing different resin quantities, acidity of sample, types of eluent, sample and eluent solution volumes, adsorption and elution flow rates, and effect of interfering ions. The detection limit of the method was 2.75 microg L(-1) while the relative standard deviation was 3.0% for 0.4 microg mL(-1) Bi(III) concentration. The developed method has been applied successfully to the determination of bismuth in pharmaceutical cream, standard reference materials and various natural water samples with satisfactory results.

  7. Biomimetic FAA-certifiable, artificial muscle structures for commercial aircraft wings

    NASA Astrophysics Data System (ADS)

    Barrett, Ronald M.; Barrett, Cassandra M.

    2014-07-01

    This paper is centered on a new form of adaptive material which functions much in the same way as skeletal muscle tissue, is structurally modeled on plant actuator cells and capable of rapidly expanding or shrinking by as much as an order of magnitude in prescribed directions. Rapid changes of plant cell shape and sizes are often initiated via ion-transport driven fluid migration and resulting turgor pressure variation. Certain plant cellular structures like those in Mimosa pudica (sensitive plant), Albizia julibrissin (Mimosa tree), or Dionaea muscipula (Venus Flytrap) all exhibit actuation physiology which employs such turgor pressure manipulation. The paper begins with dynamic micrographs of a sectioned basal articulation joint from A. julibrissin. These figures show large cellular dimensional changes as the structure undergoes foliage articulation. By mimicking such structures in aircraft flight control mechanisms, extremely lightweight pneumatic control surface actuators can be designed. This paper shows several fundamental layouts of such surfaces with actuator elements made exclusively from FAA-certifiable materials, summarizes their structural mechanics and shows actuator power and energy densities that are higher than nearly all classes of conventional adaptive materials available today. A sample flap structure is shown to possess the ability to change its shape and structural stiffness as its cell pressures are manipulated, which in turn changes the surface lift-curve slope when exposed to airflows. Because the structural stiffness can be altered, it is also shown that the commanded section lift-curve slope can be similarly controlled between 1.2 and 6.2 rad-1. Several aircraft weight reduction principles are also shown to come into play as the need to concentrate loads to pass through point actuators is eliminated. The paper concludes with a summary of interrelated performance and airframe-level improvements including enhanced gust rejection, load

  8. Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice

    PubMed Central

    Faccidomo, Sara; Salling, Michael C; Galunas, Christina; Hodge, Clyde W

    2015-01-01

    Rationale Extracellular-signal regulated protein kinase (ERK1/2) is activated by ethanol in reward-related brain regions. Accordingly, systemic inhibition of ERK1/2 potentiates ethanol reinforcement. However, the brain region(s) that mediate this effect are unknown. Objective To pharmacologically inhibit ERK1/2 in the medial prefrontal cortex (PFC), nucleus accumbens (NAC) and amygdala (AMY) prior to ethanol or sucrose self-administration, and evaluate effects of operant ethanol self-administration on ERK1/2 phosphorylation (pERK1/2). Methods Male C57BL/6J mice were trained to lever press on a fixed-ratio-4 schedule of 9% ethanol+2% sucrose (ethanol) or 2% sucrose (sucrose) reinforcement. Mice were sacrificed immediately after the 30th self-administration session and pERK1/2 immunoreactivity was quantified in targeted brain regions. Additional groups of mice were injected with SL 327 (0–1.7 μg/side) in PFC, NAC or AMY prior to self-administration. Results pERK1/2 immunoreactivity was significantly increased by operant ethanol (g/kg=1.21 g/kg; BAC=54.9 mg/dl) in the PFC, NAC (core and shell), and AMY (central nucleus) as compared to sucrose. Microinjection of SL 327 (1.7 μg) into the PFC selectively increased ethanol self-administration. Intra-NAC injection of SL 327 had no effect on ethanol- but suppressed sucrose-reinforced responding. Intra-AMY microinjection of SL 327 had no effect on either ethanol- or sucrose-reinforced responding. Locomotor activity was unaffected under all conditions. Conclusions Operant ethanol self-administration increases pERK1/2 activation in the PFC, NAC and AMY. However, ERK1/2 activity only in the PFC mechanistically regulates ethanol self-administration. These data suggest that ethanol-induced activation of ERK1/2 in the PFC is a critical pharmacological effect that mediates the reinforcing properties of the drug. PMID:26123321

  9. Sex differences in nicotine self-administration in rats during progressive unit dose reduction: Implications for nicotine regulation policy

    PubMed Central

    Grebenstein, Patricia; Burroughs, Danielle; Zhang, Yan; LeSage, Mark G.

    2013-01-01

    Reducing the nicotine content in tobacco products is being considered by the FDA as a policy to reduce the addictiveness of tobacco products. Understanding individual differences in response to nicotine reduction will be critical to developing safe and effective policy. Animal and human research demonstrating sex differences in the reinforcing effects of nicotine suggests that males and females may respond differently to nicotine-reduction policies. However, no studies have directly examined sex differences in the effects of nicotine unit-dose reduction on nicotine self-administration (NSA) in animals. The purpose of the present study was to examine this issue in a rodent self-administration model. Male and female rats were trained to self-administer nicotine (0.06 mg/kg) under an FR 3 schedule during daily 23 h sessions. Rats were then exposed to saline extinction and reacquisition of NSA, followed by weekly reductions in the unit dose (0.03 to 0.00025 mg/kg) until extinction levels of responding were achieved. Males and females were compared with respect to baseline levels of intake, resistance to extinction, degree of compensatory increases in responding during dose reduction, and the threshold reinforcing unit dose of nicotine. Exponential demand-curve analysis was also conducted to compare the sensitivity of males and females to increases in the unit price (FR/unit dose) of nicotine (i.e., elasticity of demand or reinforcing efficacy). Females exhibited significantly higher baseline intake and less compensation than males. However, there were no sex differences in the reinforcement threshold or elasticity of demand. Dose–response relationships were very well described by the exponential demand function (r2 values > 0.96 for individual subjects). These findings suggest that females may exhibit less compensatory smoking in response to nicotine reduction policies, even though their nicotine reinforcement threshold and elasticity of demand may not differ from

  10. Sex differences in nicotine self-administration in rats during progressive unit dose reduction: implications for nicotine regulation policy.

    PubMed

    Grebenstein, Patricia; Burroughs, Danielle; Zhang, Yan; LeSage, Mark G

    2013-12-01

    Reducing the nicotine content in tobacco products is being considered by the FDA as a policy to reduce the addictiveness of tobacco products. Understanding individual differences in response to nicotine reduction will be critical to developing safe and effective policy. Animal and human research demonstrating sex differences in the reinforcing effects of nicotine suggests that males and females may respond differently to nicotine-reduction policies. However, no studies have directly examined sex differences in the effects of nicotine unit-dose reduction on nicotine self-administration (NSA) in animals. The purpose of the present study was to examine this issue in a rodent self-administration model. Male and female rats were trained to self-administer nicotine (0.06mg/kg) under an FR 3 schedule during daily 23h sessions. Rats were then exposed to saline extinction and reacquisition of NSA, followed by weekly reductions in the unit dose (0.03 to 0.00025mg/kg) until extinction levels of responding were achieved. Males and females were compared with respect to baseline levels of intake, resistance to extinction, degree of compensatory increases in responding during dose reduction, and the threshold reinforcing unit dose of nicotine. Exponential demand-curve analysis was also conducted to compare the sensitivity of males and females to increases in the unit price (FR/unit dose) of nicotine (i.e., elasticity of demand or reinforcing efficacy). Females exhibited significantly higher baseline intake and less compensation than males. However, there were no sex differences in the reinforcement threshold or elasticity of demand. Dose-response relationships were very well described by the exponential demand function (r(2) values>0.96 for individual subjects). These findings suggest that females may exhibit less compensatory smoking in response to nicotine reduction policies, even though their nicotine reinforcement threshold and elasticity of demand may not differ from males

  11. Regulations for the administration and enforcement of the Radiation Control for Health and Safety Act of 1968

    SciTech Connect

    Not Available

    1988-04-01

    The purpose of the Act is to protect the public from unnecessary exposure to radiation from electronic products, including ionizing, nonionizing, electromagnetic, or particulate radiation, or any sonic, infrasonic, or ultrasonic wave. The regulations in the publication cover general provisions, statements of policy and interpretation, radiation protection recommendations, recordkeeping and reporting requirements for manufacturers, dealers, and distributors; notification requirements for defects or failure to comply; repurchase, repairs, or replacement of electronic products; importation of products; and performance standards for television receivers, cathode ray tubes, diagnostic x-ray equipment, radiographic equipment, fluoroscopic equipment, computer aided tomography equipment, microwave ovens, laser products, sunlamps, ultraviolet lamps, mercury lamps, and ultrasonic therapy products.

  12. State Regulation of Medication Administration by Unlicensed Assistive Personnel in Residential Care and Adult Day Services Settings.

    PubMed

    Carder, Paula C; O'Keeffe, Janet

    2016-09-01

    Residential care settings and adult day services are two community-based care options used by older adults with chronic health conditions. Most states have regulatory provisions that allow unlicensed assistive personnel (UAP) to administer medications. The current national policy study examined state regulations to identify which states permit UAP to administer medications, as well as staffing and training requirements. Key findings include states lack clear and adequate provisions for nurse oversight of UAP who administer medications, although adult day service regulations provide a greater level of nurse oversight than residential care settings. Specifically, 32 states require residential care to hire a nurse, but only six include provisions regarding nurse availability (e.g., on-call, on-site, number of hours). In contrast, 10 of 20 states that require adult day service programs to hire a nurse provide availability provisions. Nurse oversight of UAP is an important means of assuring quality care and reducing errors; thus, state regulatory agencies might need to strengthen nurse oversight provisions. [Res Gerontol Nurs. 2016; 9(5):209-222.]. PMID:27054368

  13. The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain.

    PubMed

    Miszkiel, Joanna; Detka, Jan; Cholewa, Joanna; Frankowska, Małgorzata; Nowak, Ewa; Budziszewska, Bogusława; Przegaliński, Edmund; Filip, Małgorzata

    2014-08-01

    According to a current hypothesis of learning processes, recent papers pointed out to an important role of the extracellular signal-regulated kinase (ERK), in drug addiction. We employed the Western blotting techniques to examine the ERK activity immediately after cocaine iv self-administration and in different drug-free withdrawal periods in rats. To distinguish motivational vs. pharmacological effects of the psychostimulant intake, a "yoked" procedure was used. Animals were decapitated after 14 daily cocaine self-administration sessions or on the 1st, 3rd or 10th extinction days. At each time point the activity of the ERK was assessed in several brain structures, including the prefrontal cortex, hippocampus, dorsal striatum and nucleus accumbens. Passive, repeated iv cocaine administration resulted in a 45% increase in ERK phosphorylation in the hippocampus while cocaine self-administration did not change brain ERK activity. On the 1st day of extinction, the activity of the ERK in the prefrontal cortex was decreased in rats with a history of cocaine chronic intake: by 66% for "active" cocaine group and by 35% for "yoked" cocaine group. On the 3rd day the reduction in the ERK activity (25-34%) was observed in the hippocampus for both cocaine-treated groups, and also in the nucleus accumbens for "yoked" cocaine group (40%). On the 10th day of extinction there was no significant alteration in ERK activity in any group of rats. Our findings suggest that cortical ERK is involved in cocaine seeking behavior in rats. They also indicate the time and regional adaptations in this enzyme activity after cocaine withdrawal. PMID:24948065

  14. 76 FR 3489 - Revision of American Viticultural Area Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... prescribe regulations for the labeling of wine, distilled spirits, and malt beverages. The FAA Act provides... appellations of origin on wine labels and in wine advertisements. Part 9 of the TTB regulations (27 CFR part 9... TTB regulations (27 CFR 4.25(e)(1)(i)) defines a viticultural area for American wine as a...

  15. Extended access to methamphetamine self-administration up-regulates dopamine transporter levels 72 hours after withdrawal in rats.

    PubMed

    D'Arcy, Christina; Luevano, Joe E; Miranda-Arango, Manuel; Pipkin, Joseph A; Jackson, Jonathan A; Castañeda, Eddie; Gosselink, Kristin L; O'Dell, Laura E

    2016-01-01

    Previous studies have demonstrated that there are persistent changes in dopamine systems following withdrawal from methamphetamine (METH). This study examined changes in striatal dopamine transporter (DAT), tyrosine hydroxylase (TH) and dopamine receptor 2 (D2) 72 h after withdrawal from METH intravenous self- administration (IVSA). Rats were given limited (1h) or extended (6h) access to METH IVSA (0.05 mg/kg/0.1 ml infusion) for 22 days. Controls did not receive METH IVSA. The rats given extended access to IVSA displayed higher METH intake during the first hour of drug access compared to rats given limited access. Extended access to METH also produced a concomitant increase in striatal DAT levels relative to drug-naïve controls. There were no changes in TH or D2 levels across groups. Previous studies have reported a decrease in striatal DAT levels during protracted periods (>7 days) of withdrawal from METH IVSA. This study extends previous work by showing an increase in striatal DAT protein expression during an earlier time point of withdrawal from this drug. These results are an important step toward understanding the dynamic changes in dopamine systems that occur during different time points of withdrawal from METH IVSA.

  16. [Comparative study on trace elements in Elsholtzia bodineri Vaniot. from Honghe by FAAS].

    PubMed

    Zhang, Ju-Cheng; Liu, Wei; Yi, Zhong-Zhou; Qiu, Cheng-Shu; Li, Ying; Yan, He-Ping

    2008-11-01

    In the present paper, the authors prepared all the samples by the same method, and optimized the work conditions for flame qtomic absorption spectrometry. FAAS was applied to determine the trace elements, such as Pb, Cr, Cd, Cu, Zn, Hg, Se etc, in Elsholtzia bodineri Vaniot. from Mengzi, Shiping, Mile and Jianshui located in Honghe state. The method is simple, rapid and accurate, and allows simultaneous determination of many elements. The recoveries were in the range of 98.7%-116.4%, and RSD was 0.07%-1.69%. The contents of Pb, Cd and Hg were 53.47, 6.03 and 7.68 microg x g(-1), respectively, in the sample from Jianshui, and were higher than those from other areas. The content of Mn was the highest, and was higher in Mengzi than in other areas, and the average content in the four samples was 913.48 microg x g(-1), which was higher than the content in the soil. Fe is the semi-microelement whose average content in Elsholtzia bodineri Vaniot. from Honghe was 688.46 microg x g(-1), the high-to-low content sequence of Fe in terms of location was Mengzi, Mile, Shiping and Jianshui. The average content of Zn was 116.64 microg x g(-1), and the highest one was from Shiping. But we did not obtain the data of Se in the Elsholtzia bodineri Vaniot. from Honghe state by AAS, and did not detect Hg in samples from Shiping and Mile. The content of the detected elements in Mengzi's sample had the sequence as follows; Mn > Fe > Zn > Pb > Cu > Cr > Cd > Hg>Se, while the sequence was Mn > Fe > Zn > Pb > Cu > Hg > Cd > Cr > Se in the sample of Jianshui, Mn > Fe > Z n >Pb > Cu > Cd > Cr > Hg > Se in Shiping, and Fe > Mn > Zn > Pb > Cu > Cd > Cr > Hg > Se in Mile. The results show that the content of the trace elements is high, especially, Mn, Fe and Zn, in Elsholtzia bodineri Vaniot. in Honghe. Therefore, Elsholtzia bodineri Vaniot., which can be used as drug or beverage, is worth exploitation. PMID:19271521

  17. Employee Retirement Income Security Act of 1974; rules and regulations for administration and enforcement; claims procedure--Department of Labor. Notice of proposed rulemaking.

    PubMed

    1998-09-01

    This document contains a proposed regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). This proposed regulation would establish new standards for the processing of group health disability, pension, and other employee benefit plan claims filed by participants and beneficiaries. In the case of group health plans, as well as certain plans providing disability benefits, the new standards are intended to ensure more timely benefit determinations, improved access to information on which a benefit determination is made, and greater assurance that participants and beneficiaries will be afforded a full and fair review of denied claims. If adopted as final, the proposed regulation would affect participants and beneficiaries of employee benefit plans, plan, fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  18. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance Federal Aviation Administration – Project 209 Control Tower and Support Building Oakland, CA

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-03-01

    This report represents findings of a design review team that evaluated construction documents (at the 70% level) and operating specifications for a new control tower and support building that will be build at Oakland, California by the Federal Aviation Administration (FAA). The focus of the review was to identify measures that could be incorporated into the final design and operating specification that would result in additional energy savings for the FAA that would not have otherwise occurred.

  19. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance Federal Aviation Administration Project 209 - Control Tower and Support Building, Las Vegas, NV

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-03-31

    This report represents findings of a design review team that evaluated construction documents (at the 70% level) and operating specifications for a new control tower and support building that will be built in Las Vegas, Nevada by the Federal Aviation Administration (FAA). The focus of the review was to identify measures that could be incorporated into the final design and operating specification that would result in additional energy savings for the FAA that would not have otherwise occurred.

  20. Separation of Cr(III) and Cr(VI) using melamine-formaldehyde resin and determination of both species in water by FAAS.

    PubMed

    Demirata, B; Tor, I; Filik, H; Afşar, H

    1996-10-01

    A method is described for the determination of Cr(VI) and total chromium by FAAS. Cr(VI) is separated from Cr(III) by adsorption on melamine-formaldehyde resin. After elution of Cr(VI) with 0.1 mol/l NaAc solution, it is analysed by FAAS. Total chromium is determined by FAAS after conversion of Cr(III) to Cr(VI) by oxidation with hydrogen peroxide, total Cr(VI) is concentrated as above. If the total concentration of chromium is sufficient, the determination can be directly made by FAAS. Cr(III) can then be calculated by subtracting Cr(VI) from the total Cr. This method was successfully applied to the determination of chromium in lake water.

  1. Rapid and sensitive ultrasonic-assisted derivatisation microextraction (UDME) technique for bitter taste-free amino acids (FAA) study by HPLC-FLD.

    PubMed

    Chen, Guang; Li, Jun; Sun, Zhiwei; Zhang, Shijuan; Li, Guoliang; Song, Cuihua; Suo, Yourui; You, Jinmao

    2014-01-15

    Amino acids, as the main contributors to taste, are usually found in relatively high levels in bitter foods. In this work, we focused on seeking a rapid, sensitive and simple method to determine FAA for large batches of micro-samples and to explore the relationship between FAA and bitterness. Overall condition optimisation indicated that the new UDME technique offered higher derivatisation yields and extraction efficiencies than traditional methods. Only 35min was needed in the whole operation process. Very low LLOQ (Lower limit of quantification: 0.21-5.43nmol/L) for FAA in twelve bitter foods was obtained, with which BTT (bitter taste thresholds) and CABT (content of FAA at BTT level) were newly determined. The ratio of CABT to BTT increased with decreasing of BTT. This work provided powerful potential for the high-throughput trace analysis of micro-sample and also a methodology to study the relationship between the chemical constituents and the taste.

  2. 7 CFR 201.3 - Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Administration § 201.3 Administrator. The Administrator of the Agricultural Marketing Service...

  3. Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2.

    PubMed

    Ruiz, María L; Villanueva, Silvina S M; Luquita, Marcelo G; Ikushiro, Shin-ichi; Mottino, Aldo D; Catania, Viviana A

    2007-11-01

    The effect of spironolactone (SL) administration on 17alpha-ethynylestradiol (EE)-induced cholestasis was studied, with emphasis on expression and activity of Mrps. Adult male Wistar rats were divided into the following groups: EE (5 mg/kg daily for 5 days, s.c.), SL (200 micromol/kg daily for 3 days, i.p.), EE+SL (same doses, SL administered the last 3 days of EE treatment), and controls. SL prevented the decrease in bile salt-independent fraction of bile flow induced by EE, in association with normalization of biliary excretion of glutathione. Western blot studies indicate that EE decreased the expression of multidrug resistance-associated protein 2 (Mrp2) by 41% and increased that of Mrp3 by 200%, whereas SL only affected Mrp2 expression (+60%) with respect to controls. The EE+SL group showed increased levels of Mrp2 and Mrp3 to the same extent as that registered for the individual treatments. Real-time polymerase chain reaction studies indicated that up-regulation of Mrp2 and Mrp3 by SL and EE, respectively, was at the transcriptional level. To estimate Mrp2 and Mrp3 activities, apical and basolateral excretion of acetaminophen glucuronide (APAP-glu), a common substrate for both transporters, was measured in the recirculating isolated perfused liver model. Biliary/perfusate excretion ratio was decreased in EE (-88%) and increased in SL (+36%) with respect to controls. Coadministration of rats with SL partially prevented (-53%) impairment induced by EE in this ratio. In conclusion, SL administration to EE-induced cholestatic rats counteracted the decrease in bile flow and biliary excretion of glutathione and APAP-glu, a model Mrp substrate, findings associated with up-regulation of Mrp2 expression. PMID:17686906

  4. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala.

    PubMed

    Kenny, Paul J; Chartoff, Elena; Roberto, Marisa; Carlezon, William A; Markou, Athina

    2009-01-01

    Nicotine is considered an important component of tobacco responsible for the smoking habit in humans. Nicotine increases glutamate-mediated transmission throughout brain reward circuitries. This action of nicotine could potentially contribute to its intrinsic rewarding and reward-enhancing properties, which motivate consumption of the drug. Here we show that the competitive N-methyl-D-aspartate (NMDA) receptor antagonist LY235959 (0.5-2.5 mg per kg) abolished nicotine-enhanced brain reward function, reflected in blockade of the lowering of intracranial self-stimulation (ICSS) thresholds usually observed after experimenter-administered (0.25 mg per kg) or intravenously self-administered (0.03 mg per kg per infusion) nicotine injections. The highest LY235959 dose (5 mg per kg) tested reversed the hedonic valence of nicotine from positive to negative, reflected in nicotine-induced elevations of ICSS thresholds. LY235959 doses that reversed nicotine-induced lowering of ICSS thresholds also markedly decreased nicotine self-administration without altering responding for food reinforcement, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor antagonist NBQX had no effects on nicotine intake. In addition, nicotine self-administration upregulated NMDA receptor subunit expression in the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA), suggesting important interactions between nicotine and the NMDA receptor. Furthermore, nicotine (1 microM) increased NMDA receptor-mediated excitatory postsynaptic currents in rat CeA slices, similar to its previously described effects in the VTA. Finally, infusion of LY235959 (0.1-10 ng per side) into the CeA or VTA decreased nicotine self-administration. Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug.

  5. Single session of cocaine intravenous self-administration shapes goal-oriented behaviours and up-regulates Arc mRNA levels in rat medial prefrontal cortex.

    PubMed

    Fumagalli, Fabio; Franchi, Carlotta; Caffino, Lucia; Racagni, Giorgio; Riva, Marco A; Cervo, Luigi

    2009-04-01

    To separate the direct pharmacological effects of cocaine from those associated with active drug self-administration we employed a yoked control-operant paradigm and investigated the expression of well established markers of the rapid action of cocaine, i.e. the inducible early genes Arc and Zif268 and trophic factors, i.e. brain-derived neurotrophic factor (BDNF) and basic fibroblast growth factor (FGF-2), in rats after a single intravenous (i.v.) cocaine self-administration session. Animals self-administering cocaine (SA, 0.25 mg/0.1 ml saline per infusion, 2-h session) did more active lever-presses than yoked-cocaine (YC) and yoked-vehicle (YV) animals. This goal-oriented behaviour was accompanied by a selective increase in Arc mRNA levels in the medial prefrontal cortex (mPFC). There were no changes in the expression of the other genes in this brain region. mRNA levels of Arc and Zif268 in striatum and Zif268 in the nucleus accumbens markedly increased both in SA and YC animals; but there was no change in the expression of FGF-2 and BDNF. No changes were observed in hippocampus, hypothalamus, frontal cortex, and midbrain in SA and YC animals compared to YV animals in any of the genes. These findings demonstrate that a single session of cocaine i.v. self-administration is sufficient to shape rat behaviour towards goal-directed behaviours and selectively up-regulate Arc expression in mPFC (of SA animals), providing the first evidence that the mPFC's function is already profoundly influenced by the first voluntary cocaine exposure.

  6. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: Role of the ventral tegmental area and central nucleus of the amygdala

    PubMed Central

    Kenny, Paul J.; Chartoff, Elena; Roberto, Marisa; Carlezon, William A.; Markou, Athina

    2009-01-01

    Nicotine is considered an important component of tobacco responsible for the smoking habit in humans. Nicotine increases glutamate-mediated transmission throughout brain reward circuitries. This action of nicotine could potentially contribute to its intrinsic rewarding and reward-enhancing properties, which motivate consumption of the drug. Here we show that the competitive N-methyl-D-aspartate (NMDA) receptor antagonist LY235959 (0.5–2.5 mg/kg) abolished nicotine-enhanced brain reward function, reflected in blockade of the lowering of intracranial self-stimulation (ICSS) thresholds usually observed after experimenter-administered (0.25 mg/kg) or intravenously self-administered (0.03 mg/kg/infusion) nicotine injections. The highest LY235959 dose (5 mg/kg) tested reversed the hedonic valence of nicotine from positive to negative, reflected in nicotine-induced elevations of ICSS thresholds. LY235959 doses that reversed nicotine-induced lowering of ICSS thresholds also markedly decreased nicotine self-administration without altering responding for food reinforcement, whereas the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist NBQX had no effects on nicotine intake. In addition, nicotine self-administration upregulated NMDA receptor subunit expression in the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA), suggesting important interactions between nicotine and the NMDA receptor. Furthermore, nicotine (1 μM) increased NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in rat CeA slices, similar to its previously described effects in the VTA. Finally, infusion of LY235959 (0.1–10 ng/side) into the CeA or VTA decreased nicotine self-administration. Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug. PMID:18418357

  7. 14 CFR 11.33 - How can I track FAA's rulemaking activities?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... docket number or the regulation identifier number. (a) Docket ID. We assign a docket ID to each... well as public comments on the proceeding, will display the same docket ID. This ID allows you to....regulations.gov. If you can't find the material in the electronic docket, contact the person listed under...

  8. 14 CFR 11.33 - How can I track FAA's rulemaking activities?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... docket number or the regulation identifier number. (a) Docket ID. We assign a docket ID to each... well as public comments on the proceeding, will display the same docket ID. This ID allows you to....regulations.gov. If you can't find the material in the electronic docket, contact the person listed under...

  9. 14 CFR 11.33 - How can I track FAA's rulemaking activities?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... docket number or the regulation identifier number. (a) Docket ID. We assign a docket ID to each... well as public comments on the proceeding, will display the same docket ID. This ID allows you to....regulations.gov. If you can't find the material in the electronic docket, contact the person listed under...

  10. 14 CFR 11.33 - How can I track FAA's rulemaking activities?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... docket number or the regulation identifier number. (a) Docket ID. We assign a docket ID to each... well as public comments on the proceeding, will display the same docket ID. This ID allows you to....regulations.gov. If you can't find the material in the electronic docket, contact the person listed under...

  11. 14 CFR 11.33 - How can I track FAA's rulemaking activities?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... docket number or the regulation identifier number. (a) Docket ID. We assign a docket ID to each... well as public comments on the proceeding, will display the same docket ID. This ID allows you to....regulations.gov. If you can't find the material in the electronic docket, contact the person listed under...

  12. 7 CFR 62.100 - Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Definitions Administration § 62.100 Administrator. The LS Program Deputy Administrator is charged with the administration of official assessments conducted according to the regulations in this part and approved...

  13. Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.

    PubMed

    Yang, Yan; Yang, Fei; Yang, Fan; Li, Chun-Li; Wang, Yan; Li, Zhen; Lu, Yun-Fei; Yu, Yao-Qing; Fu, Han; He, Ting; Sun, Wei; Wang, Rui-Rui; Chen, Jun

    2016-02-01

    The α2δ-1 subunit of the voltage-gated Ca(2+) channel (VGCC) is a molecular target of gabapentin (GBP), which has been used as a first-line drug for the relief of neuropathic pain. GBP exerts its anti-nociceptive effects by disrupting trafficking of the α2δ-1 subunit to the presynaptic membrane, resulting in decreased neurotransmitter release. We previously showed that GBP has an anti-allodynic effect in the first two weeks; but this is followed by insensitivity in the later stage after repeated administration in a rat model of central post-stroke pain (CPSP) hypersensitivity induced by intra-thalamic hemorrhage. To explore the mechanisms underlying GBP insensitivity, the cellular localization and time-course of expression of the α2δ-1 subunit in both the thalamus and spinal dorsal horn were studied in the same model. We found that the α2δ-1 subunit was mostly localized in neurons, but not astrocytes and microglia. The level of α2δ-1 protein increased in the first two weeks after injury but then decreased in the third week, when GBP insensitivity occurred. Furthermore, the α2δ-1 down-regulation was likely caused by later neuronal loss in the injured thalamus through a mechanism other than apoptosis. In summary, the present results suggest that the GBP receptor α2δ-1 is mainly expressed in thalamic neurons in which it is up-regulated in the early stage of CPSP but this is followed by dramatic down-regulation, which is likely associated with GBP insensitivity after long-term use. PMID:26781878

  14. Results from FAA program to validate bonded composite doublers for commercial aviation use

    SciTech Connect

    Roach, D.P.

    1997-09-01

    The number of commercial airframes exceeding twenty years of service continues to grow. In addition, Service Life Extension Programs are attempting to extend the {open_quotes}economic{close_quotes} service life of commercial airframes to thirty years. The use of bonded composites may offer the airframe manufacturers and aircraft maintenance facilities a cost effective method to extend the lives of their aircraft. The Federal Aviation Administration Assurance NDI Validation Center (AANC) to validate the use of bonded composite doublers on commercial aircraft.

  15. Intracerebroventricular administration of ouabain, a Na/K-ATPase inhibitor, activates tyrosine hydroxylase through extracellular signal-regulated kinase in rat striatum.

    PubMed

    Yu, Hyun Sook; Kim, Se Hyun; Park, Hong Geun; Kim, Yong Sik; Ahn, Yong Min

    2011-11-01

    Alteration in dopamine neurotransmission has been reported to be involved in the mania of bipolar disorder. Tyrosine hydroxylase (TH) is the rate-limiting enzyme that is crucial for dopamine biosynthesis, and its activity is tightly regulated by phosphorylation at multiple N-terminal serine residues. Previously, we have reported that intracerebroventricular (ICV) injection of ouabain, a selective Na/K-ATPase inhibitor, induces hyperactivity in rats that mimics manic symptoms related to the activation of extracellular signal-regulated protein kinase1/2 (ERK1/2), which plays crucial roles in the modulation of TH phosphorylation. In this study, we investigated the effects of ICV injection of ouabain on TH phosphorylation in rat striatum and the involvement of ERK1/2 in ouabain-induced TH activation. ICV ouabain induced an acute dose-dependent increase in locomotor activity and in TH phosphorylation in rat striatum. TH phosphorylation at Ser19 was significantly increased with 100, 500, and 1000μM ouabain, and phosphorylation at Ser31 and Ser40 was significantly increased with 500 and 1000μM. We also found that ICV pretreatment with U0126, a specific MEK1/2 inhibitor, attenuated the 1000μM ouabain-induced increase in TH phosphorylation at Ser19, Ser31, and Ser40, as well as the hyperactivity of rats. Moreover, the increased phosphorylation of TH (Ser19, Ser31, and Ser40) was maintained until 8h after single administration ouabain was accompanied by increased phosphorylation of ERK1/2 (Thr202/Tyr204) and p90RSK (Thr359/Ser363). These findings imply that TH activation of the ERK1/2 signal pathway could play an important role in ouabain-induced hyperactivity of rats, a mania model. PMID:21871514

  16. Embracing 21st Century Information Sharing: Defining a New Paradigm for the Food and Drug Administration's Regulation of Biopharmaceutical Company Communications with Healthcare Professionals.

    PubMed

    Spears, James M; Francer, Jeffrey K; Turner, Natale A

    2015-01-01

    The Food and Drug Administration (FDA) plays a unique role in protecting the public health and minimizing the risk of the distribution of unsafe or ineffective medicines in the United States. Perhaps equally as important for public health, however, is the need for healthcare professionals to be well informed about the benefits and risks of the medicines they prescribe. In this way, information sharing is critical to healthcare delivery. FDA's current interpretation of laws and regulations governing healthcare communications prohibits biopharmaceutical companies from sharing certain accurate, data-driven information about FDA-approved uses and medically accepted alternative uses of FDA-approved drugs with healthcare professionals. Often, these uses are the standard of care for good medical practice and are, accordingly, reimbursed under the federal healthcare programs. FDA has failed to describe adequately how manufacturers can share truthful and non-misleading information about such uses with healthcare professionals and formulary decision makers. This failure could impede medical innovation, negatively impact patient care, and increase healthcare costs. To improve public health, FDA should reform its current approach and provide manufacturers with a clear safe harbor on how to share data and information on both approved uses and medically accepted alternative uses of FDA-approved drugs with healthcare professionals. This Article describes key principles for a new regulatory paradigm.

  17. Optimization of Ultrasound-Assisted Extraction of Cr, Cu, Zn, Cd, and Pb from Sediment, Followed by FAAS and GFAAS Analysis.

    PubMed

    Mimura, Aparecida M S; Oliveira, Marcone A L; Ciminelli, Virginia S T; Silva, Julio C J

    2016-01-01

    An ultrasound method for simultaneous extraction of Cr, Cu, Zn, Cd, and Pb from sediment, and determination by flame atomic absorption spectrometry (FAAS) and graphite furnace atomic absorption spectrometry (GFAAS) was proposed. The experimental results obtained using analytical curves and the method of standard additions agreed at a confidence level of 95% for all the analytes, as determined by FAAS and GFAAS, indicating no significant matrix effects. Recoveries ranged from 80.1 to 93.7% (certified reference material) and from 89 to 107% (spike tests). The LOD and LOQ results from the method were consistent with the techniques used (FAAS and GFAAS), with high analytical throughput. The proposed method was then used to determine Cr, Cu, Zn, Cd, and Pb in river sediment samples from Rio Doce, Minas Gerais, Brazil. The results indicated levels below those permitted by Brazilian legislation for all the analytes, with the exception of Cr. PMID:26851077

  18. FirstAidAssistanceSystem (FAAS): improvement of first aid measures using Car2Car-communication technology

    NASA Astrophysics Data System (ADS)

    Tuchscheerer, Sven; Hoppe, Tobias; Krätzer, Christian; Dittmann, Jana

    2011-01-01

    This work's goal is the enhancement of first aid measures directly after car accidents by calling suited first aiders via Car-to-Car (C2C) communication and to assist them providing detailed multimedia support instructions. Our concept combines upcoming C2C communication technologies with established technology, in particular GPS and GSM. After a collision, the proposed FirstAidAssistanceSystem (FAAS) sends a broadcast message using C2C technology according to the IEEE 802.11p standard. All nearby cars (as potential first aiders) are located and at least one nearest candidate (we suggest 3-5) driving towards the accident scene is chosen and notified as first aider. A support guide on his multipurpose display (e.g. the navigation system) provides first aiders with detailed instructions and illustrative tutorials. The paper presents our concept in detail with a discussion of practical evaluation criteria and an introduction of a first test implementation.

  19. Impaired recovery of brain muscarinic receptor sites following an adaptive down-regulation induced by repeated administration of diisopropyl fluorophosphate in aged rats

    SciTech Connect

    Pintor, A.; Fortuna, S.; De Angelis, S.; Michalek, H. )

    1990-01-01

    Potential age-related differences in the recovery rate of brain cholinesterase activity (ChE) and muscarinic acetylcholine receptor binding sites (mAChRs) following reduction induced by repeated treatment with diisopropyl fluorophosphate (DFP) were evaluated in Sprague-Dawley rats. Male 3- and 24-month old rats were s.c. injected with DFP on alternate days for 2 weeks and killed 48 hr and 7, 14, 21, 28 and 35 days after the last treatment. In the hippocampus and striatum, but not in the cerebral cortex, of control rats there as a significant age-related decline of ChE activity and maximal density of 3H-QNB binding sites (Bmax). The repeated administration of DFP during the first week caused a syndrome of cholinergic stimulation both in aged and young rats. The syndrome was more pronounced, in terms of intensity and duration in aged than in young animals resulting in 40 and 12% mortality, respectively; during the second week the syndrome attenuated in the two age-groups. The percentage inhibition of brain ChE at the end of DFP treatment did not differ between young and surviving aged rats. The down-regulation of mACRs was present in the three brain regions of both young and age rats (from 20 to 40%). Factorial analysis of variance showed significant differences for age, recovery rate, and significant interaction between age and recovery rate, both for ChE and mAChRs in young rats the three brain areas.

  20. 48 CFR 3028.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administration. 3028.106 Section 3028.106 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY... 3028.106 Administration....

  1. Attitudes on En Route Air Traffic Control Training and Work: A Comparison of Recruits Initially Trained at the FAA Academy and Recruits Initially Trained at Assigned Centers.

    ERIC Educational Resources Information Center

    Mathews, John J.; And Others

    In the comparison, questionnaires concerning aspects of training-related and work-related attitudes were sent to 225 Air Traffic Control (ATC) trainees who represented groups of attritions and retentions in two En Route training programs; viz, programs that provided basic training at the FAA Academy and programs that provided basic training at the…

  2. 41 CFR 102-33.230 - May we use military FSCAP on non-military FAA-type certificated Government aircraft?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false May we use military FSCAP on non-military FAA-type certificated Government aircraft? 102-33.230 Section 102-33.230 Public... Aircraft Parts Managing Aircraft Parts § 102-33.230 May we use military FSCAP on non-military...

  3. 41 CFR 102-33.230 - May we use military FSCAP on non-military FAA-type certificated Government aircraft?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false May we use military FSCAP on non-military FAA-type certificated Government aircraft? 102-33.230 Section 102-33.230 Public... Aircraft Parts Managing Aircraft Parts § 102-33.230 May we use military FSCAP on non-military...

  4. Determination of Fe Content of Some Food Items by Flame Atomic Absorption Spectroscopy (FAAS): A Guided-Inquiry Learning Experience in Instrumental Analysis Laboratory

    ERIC Educational Resources Information Center

    Fakayode, Sayo O.; King, Angela G.; Yakubu, Mamudu; Mohammed, Abdul K.; Pollard, David A.

    2012-01-01

    This article presents a guided-inquiry (GI) hands-on determination of Fe in food samples including plantains, spinach, lima beans, oatmeal, Frosted Flakes cereal (generic), tilapia fish, and chicken using flame atomic absorption spectroscopy (FAAS). The utility of the GI experiment, which is part of an instrumental analysis laboratory course,…

  5. 18 CFR 415.40 - Administrative agency.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 2 2011-04-01 2011-04-01 false Administrative agency. 415.40 Section 415.40 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-FLOOD PLAIN REGULATIONS Administration § 415.40 Administrative agency....

  6. 18 CFR 415.40 - Administrative agency.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Administrative agency. 415.40 Section 415.40 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL BASIN REGULATIONS-FLOOD PLAIN REGULATIONS Administration § 415.40 Administrative agency....

  7. 48 CFR 702.170-2 - Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administrator. 702.170-2 Section 702.170-2 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL DEFINITIONS OF WORDS AND TERMS Definitions 702.170-2 Administrator. Administrator means the Administrator...

  8. 48 CFR 30.607 - Subcontract administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Subcontract administration. 30.607 Section 30.607 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Administration 30.607...

  9. 5 CFR 179.307 - Administrative offset.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 179.307 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS... administrative offset regulations, and the applicable provisions of 4 CFR part 102 with respect to providing the... administrative offset regulations and with the applicable provisions of 4 CFR part 102, including providing...

  10. Administrative Synergy

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  11. 75 FR 77569 - Special Conditions: Gulfstream Model GVI Airplane; Electronic Flight Control System Mode...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-13

    ...; Electronic Flight Control System Mode Annunciation AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... design features include an electronic flight control system. The applicable airworthiness regulations do... INFORMATION CONTACT: Joe Jacobsen, FAA, Airplane and Flight Crew Interface Branch, ANM-111,...

  12. [Preparation of Pb2+ imprinted acrylic acid-co-styrene and analysis of its adsorption properties by FAAS].

    PubMed

    Shawket, Abliz; Abdiryim, Supahun; Wang, Ji-De; Ismayil, Nurulla

    2011-06-01

    With lead ion template, acrylic acid as functional monomer, potassium persulfate as initiator, strytrene as framework monomer, lead ion imprinted polymers (Pb(II)-IIPs) were prepared using free emulsion polymerization method. The structure and morphology of the polymers were analyzed by UV-spectra, FTIR and scanning electron microscopy. The adsorption/ desorption and selectivity for Pb2+ were investigated by flame atomic absorption spectrometry (FAAS) as the detection means. The results show that compared with non-imprinted polymers(NIPs), the Pb(II)-IIPs had higher specific adsorption properties and selective recognition ability for Pb(II). The relative selectivity coefficient of Pb(II)-IIPs for Pb(II) was 6.25, 6.18, 6.25 and 6.38 in the presence of Cd(II), Cu(II), Mn(II) and Zn(II) interferences, respectively. The absorption rate was the best at the pH of adsorbent solution of 6, Adsorption rate reached 96% during the 2.5 h static adsorption time. Using 3.0 mol x L(-1) HCI as the best desorption solvent to desorb the adsorbents, the desorbtion rate reached 98%. Under the best adsorption conditions, the adsorption capacity of Pb(II)-IIPs for Pb(II) was found to be 40. mg x g(-1). PMID:21847962

  13. Determination of toxic heavy metals in sea water by FAAS after preconcentration with a novel chelating resin.

    PubMed

    Manivannan, D; Biju, V M

    2011-01-01

    A solid phase extraction procedure was developed for preconcentration of toxic heavy metals such as cadmium, cobalt, copper, manganese, lead and zinc in sea water samples. A microcolumn packed with 6-[(4-hydroxyphenyl)diazenyl]naphthalene-2,3-diol-formaldehyde (HPDN-F) resin acts as a sorbent to retain the analyte ions by forming metal chelates. The retained trace level metal was subsequently eluted with 1 mol/L HCl and the acid eluent was analysed by Flame Atomic Absorption Spectrophotometer (FAAS). The HPDN-F chelating resin and its metal chelates were characterized by spectral and thermal analysis. The chelating property of the HPDN-F resin towards divalent metal ions was studied as a function of pH and preconcentration flow rate. The recoveries of cadmium, cobalt, copper, manganese, lead and zinc under the optimum working conditions were above 95%. The relative standard deviations were < 2%. The limits of detection were < 0.1 microg/L. The method presented was applied for the determination of cadmium, cobalt, copper, manganese, lead and zinc in sea water samples.

  14. Navigation and flight director guidance for the NASA/FAA helicopter MLS curved approach flight test program

    NASA Technical Reports Server (NTRS)

    Phatak, A. V.; Lee, M. G.

    1985-01-01

    The navigation and flight director guidance systems implemented in the NASA/FAA helicopter microwave landing system (MLS) curved approach flight test program is described. Flight test were conducted at the U.S. Navy's Crows Landing facility, using the NASA Ames UH-lH helicopter equipped with the V/STOLAND avionics system. The purpose of these tests was to investigate the feasibility of flying complex, curved and descending approaches to a landing using MLS flight director guidance. A description of the navigation aids used, the avionics system, cockpit instrumentation and on-board navigation equipment used for the flight test is provided. Three generic reference flight paths were developed and flown during the test. They were as follows: U-Turn, S-turn and Straight-In flight profiles. These profiles and their geometries are described in detail. A 3-cue flight director was implemented on the helicopter. A description of the formulation and implementation of the flight director laws is also presented. Performance data and analysis is presented for one pilot conducting the flight director approaches.

  15. [Two steps elution method FI on-line adsorption and preconcentration coupled with FAAS for the determination of trace zinc].

    PubMed

    Wang, Zhong-yuan; Zhang, Hong-kang; Fang, Hong-da; Su, Yao-dong; Mittal, Gauri S

    2011-12-01

    A flow injection two steps elution method on-line sorption and preconcentration system coupled to flame atomic absorption spectrometry (FAAS) was developed for the determination of trace Zn in water samples. The conventional elution procedure was divided into two steps: elution procedure and detection procedure. During the elution procedure, the eluent was pumped into KR by the suction of the peristaltic pump and through PTFE tube instead of peristaltic pump tube. By the new method, the dispersion of the analyte was decreased notably, and high absorbance peak value was achieved. Because the eluent was not through the peristaltic pump tube, the peristaltic pump tube was protected from being eroded. Emptying procedure was added in order to insure the veracity and repeatability of the experiment of every time. With 60 s (sample throughput of 37 x h(-1)) of sampling at a flow rate of 6.0 mL x min(-1), an enhancement factor (EF) of 28 (higher than 9 achieved by conventional elution method) and a detection limit (3sigma) of 0.35 x L(-1) were obtained. The precision (RSD, n=11) was 2.1% at the 20 microg x L(-1) level. When 0.1% phi triethannolamine was used as masking reagent, the recovery rate was from 98.7% to 99.6%.

  16. Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

    PubMed Central

    Gallardo, Christian M; Darvas, Martin; Oviatt, Mia; Chang, Chris H; Michalik, Mateusz; Huddy, Timothy F; Meyer, Emily E; Shuster, Scott A; Aguayo, Antonio; Hill, Elizabeth M; Kiani, Karun; Ikpeazu, Jonathan; Martinez, Johan S; Purpura, Mari; Smit, Andrea N; Patton, Danica F; Mistlberger, Ralph E; Palmiter, Richard D; Steele, Andrew D

    2014-01-01

    Daily rhythms of food anticipatory activity (FAA) are regulated independently of the suprachiasmatic nucleus, which mediates entrainment of rhythms to light, but the neural circuits that establish FAA remain elusive. In this study, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly reduced FAA, whereas mice lacking the dopamine D2 receptor have normal FAA. To determine where dopamine exerts its effect, we limited expression of dopamine signaling to the dorsal striatum of dopamine-deficient mice; these mice developed FAA. Within the dorsal striatum, the daily rhythm of clock gene period2 expression was markedly suppressed in D1R KO mice. Pharmacological activation of D1R at the same time daily was sufficient to establish anticipatory activity in wild-type mice. These results demonstrate that dopamine signaling to D1R-expressing neurons in the dorsal striatum plays an important role in manifestation of FAA, possibly by synchronizing circadian oscillators that modulate motivational processes and behavioral output. DOI: http://dx.doi.org/10.7554/eLife.03781.001 PMID:25217530

  17. 5 CFR 831.101 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Administration. 831.101 Section 831.101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Administration and General Provisions § 831.101 Administration. (a) OPM has charge of...

  18. Administrative Actions for Noncompliance; Lesser Administrative Actions. Direct final rule.

    PubMed

    2016-04-01

    The Food and Drug Administration (FDA) is amending the regulation describing lesser administrative actions that may be imposed on an Institutional Review Board (IRB) that has failed to comply with FDA's IRB regulations. We are clarifying that FDA may require the IRB to withhold approval of new FDA-regulated studies, stop the enrollment of new subjects in ongoing studies, and terminate ongoing studies, or any combination of these actions until the noncompliance with FDA's IRB regulations is corrected. We are taking this action to ensure clarity and improve the accuracy of the regulations.

  19. Further increased production of free fatty acids by overexpressing a predicted transketolase gene of the pentose phosphate pathway in Aspergillus oryzae faaA disruptant.

    PubMed

    Tamano, Koichi; Miura, Ai

    2016-09-01

    Free fatty acids are useful as source materials for the production of biodiesel fuel and various chemicals such as pharmaceuticals and dietary supplements. Previously, we attained a 9.2-fold increase in free fatty acid productivity by disrupting a predicted acyl-CoA synthetase gene (faaA, AO090011000642) in Aspergillus oryzae. In this study, we achieved further increase in the productivity by overexpressing a predicted transketolase gene of the pentose phosphate pathway in the faaA disruptant. The A. oryzae genome is predicted to have three transketolase genes and overexpression of AO090023000345, one of the three genes, resulted in phenotypic change and further increase (corresponding to an increased production of 0.38 mmol/g dry cell weight) in free fatty acids at 1.4-fold compared to the faaA disruptant. Additionally, the biomass of hyphae increased at 1.2-fold by the overexpression. As a result, free fatty acid production yield per liter of liquid culture increased at 1.7-fold by the overexpression.

  20. Remotely Operated Aircraft (ROA) Impact on the National Airspace System (NAS) Work Package, 2005: Composite Report on FAA Flight Plan and Operational Evaluation Plan. Version 7.0

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The purpose of this document is to present the findings that resulted from a high-level analysis and evaluation of the following documents: (1) The OEP (Operational Evolution Plan) Version 7 -- a 10-year plan for operational improvements to increase capacity and efficiency in U.S. air travel and transport and other use of domestic airspace. The OEP is the FAA commitment to operational improvements. It is outcome driven, with clear lines of accountability within FAA organizations. The OEP concentrates on operational solutions and integrates safety, certification, procedures, staffing, equipment, avionics and research; (2) The Draft Flight Plan 2006 through 2010 -- a multi-year strategic effort, setting a course for the FAA through 2001, to provide the safest and most efficient air transportation system in the world; (3) The NAS System Architecture Version 5 -- a blueprint for modernizing the NAS and improving NAS services and capabilities through the year 2015; and (4) The NAS-SR-1000 System Requirements Specification (NASSRS) -- a compilation of requirements which describe the operational capabilities for the NAS. The analysis is particularly focused on examining the documents for relevance to existing and/or planned future UAV operations. The evaluation specifically focuses on potential factors that could materially affect the development of a commercial ROA industry, such as: (1) Design limitations of the CNS/ATM system, (2) Human limitations, The information presented was taken from program specifications or program office lead personnel.

  1. Administrative Ecology

    ERIC Educational Resources Information Center

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  2. Administrative Support.

    ERIC Educational Resources Information Center

    Doran, Dorothy; And Others

    This guide is intended to assist business education teachers in administrative support courses. The materials presented are based on the Arizona validated occupational competencies and tasks for the occupations of receptionist, secretary, and administrative assistant. Word processing skills have been infused into each of the three sections. The…

  3. Regulating private human suborbital flight at the international and European level: Tendencies and suggestions

    NASA Astrophysics Data System (ADS)

    Masson-Zwaan, Tanja; Moro-Aguilar, Rafael

    2013-12-01

    In the context of the FAST20XX project (Future High-Altitude High-Speed Transport) that started in 2009 under the 7th Framework Programme of the European Union (EU), the authors reexamined the legal status of private human suborbital flight, and researched whether it might be regulated as aviation or as spaceflight. International space law is ambiguous as to accommodating suborbital activities. While some provisions of the UN outer space treaties would seem to exclude them, generally there is not any explicit condition in terms of reaching orbit as a requirement for application. International air law presents equal difficulties in dealing with this activity. The classic definition of "aircraft" as contained in the Annexes to the Chicago Convention does not really encompass the kind of rocket-powered vehicles that are envisaged here. As a result, it is unclear whether the United Nations Committee on the Peaceful Uses of Outer Space (COPUOS), the International Civil Aviation Organization (ICAO), or both could be involved in an eventual international regulation of suborbital flight. In the absence of a uniform international regime, each state has the sovereign right to regulate human suborbital flights operating within its airspace. So far, two practical solutions have been realised or proposed, and will be analyzed. On the one hand, the USA granted power for regulation and licensing over private human suborbital flight to the Office of Commercial Space Transportation of the Federal Aviation Administration (FAA/AST). Subsequent regulations by the FAA have set out a series of requirements for companies that want to operate these flights, enabling a market to develop. On the other side of the Atlantic, both the European Space Agency (ESA) and a group of representatives of the European Aviation Safety Agency (EASA) of the European Union (EU) seem to rather regard this activity as aviation, potentially subject to the regulation and certification competences of EASA

  4. 49 CFR 1540.117 - Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... the Assistant Administrator for Intelligence for TSA. Date of service means— (1) The date of personal... other evidence if there is no certificate of service or postmark. Deputy Administrator means the officer...— (1) A threat to transportation or national security; (2) A threat of air piracy or terrorism; (3)...

  5. 49 CFR 1540.117 - Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the Assistant Administrator for Intelligence for TSA. Date of service means— (1) The date of personal... other evidence if there is no certificate of service or postmark. Deputy Administrator means the officer...— (1) A threat to transportation or national security; (2) A threat of air piracy or terrorism; (3)...

  6. 49 CFR 1540.117 - Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the Assistant Administrator for Intelligence for TSA. Date of service means— (1) The date of personal... other evidence if there is no certificate of service or postmark. Deputy Administrator means the officer...— (1) A threat to transportation or national security; (2) A threat of air piracy or terrorism; (3)...

  7. American Recovery and Reinvestment Act (ARRA) - FEMP Technical Assistance - Federal Aviation Administration - Project 209 - Control Tower and Support Building, Boise, Idaho

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-06-28

    This report documents an energy audit performed by Pacific Northwest National Laboratory (PNNL) and Redhorse Corporation (Redhorse) conducted on the Federal Aviation Administration (FAA) control tower and base building in Boise, Idaho. This report presents findings of the energy audit team that evaluated construction documents and operating specifications (at the 100% level) followed by a site visit of the facility under construction. The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for FAA that would not have otherwise occurred.

  8. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance Federal Aviation Administration – Project 209 Control Tower and Support Building, Reno, Nevada

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-06-30

    Pacific Northwest National Laboratory (PNNL) and Redhorse Corporation (Redhorse) conducted an energy audit on the Federal Aviation Administration (FAA) control tower and base building in Reno, Nevada. This report presents the findings of the energy audit team that evaluated construction documents and operating specifications (at the 100% level) and completed a site visit. The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for the FAA that would not have otherwise occurred.

  9. 7 CFR 29.51 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Administration. 29.51 Section 29.51 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Administration § 29.51 Administration. The Director is charged with the supervision...

  10. 7 CFR 57.10 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Administration. 57.10 Section 57.10 Agriculture... PRODUCTS INSPECTION ACT) Regulations Governing the Inspection of Eggs General § 57.10 Administration. The... require in the enforcement or administration of the provisions of the act and the regulations in this...

  11. Complying with the Drug-Free Schools and Campuses Regulations (34 CFR Part 86). A Guide for University and College Administrators.

    ERIC Educational Resources Information Center

    Pittayathikhun, Tanutda; Ku, Richard; Rigby, Donna; Mattsson, Marilyn; DeJong, William

    This document describes ways in which higher education institutions have responded to the requirements of the 1989 amendments to the Drug-Free Schools and Campuses Act, Part 86, Regulations, and is intended to help institutions improve current programs and avoid overlooking requirements that might result in noncompliance. Chapter 1 presents the…

  12. Policies, Procedures, Guidelines, Rules and Regulations for the Administration and Operation of Public Junior Colleges. (Compilation of Existing Actions of the Illinois Junior College Board.)

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    This document is a compilation of existing policies, procedures, guidelines, rules, and regulations previously adopted by the Illinois Junior College Board, from its establishment in September 1965 through May 1973. Also in the document is a listing of due dates for various documents that are to be sent to the board office during the following…

  13. α6β2*-subtype nicotinic acetylcholine receptors are more sensitive than α4β2*-subtype receptors to regulation by chronic nicotine administration.

    PubMed

    Marks, Michael J; Grady, Sharon R; Salminen, Outi; Paley, Miranda A; Wageman, Charles R; McIntosh, J Michael; Whiteaker, Paul

    2014-07-01

    Nicotinic acetylcholine receptors (nAChR) of the α6β2* subtype (where *indicates the possible presence of additional subunits) are prominently expressed on dopaminergic neurons. Because of this, their role in tobacco use and nicotine dependence has received much attention. Previous studies have demonstrated that α6β2*-nAChR are down-regulated following chronic nicotine exposure (unlike other subtypes that have been investigated - most prominently α4β2* nAChR). This study examines, for the first time, effects across a comprehensive chronic nicotine dose range. Chronic nicotine dose-responses and quantitative ligand-binding autoradiography were used to define nicotine sensitivity of changes in α4β2*-nAChR and α6β2*-nAChR expression. α6β2*-nAChR down-regulation by chronic nicotine exposure in dopaminergic and optic-tract nuclei was ≈three-fold more sensitive than up-regulation of α4β2*-nAChR. In contrast, nAChR-mediated [(3) H]-dopamine release from dopamine-terminal region synaptosomal preparations changed only in response to chronic treatment with high nicotine doses, whereas dopaminergic parameters (transporter expression and activity, dopamine receptor expression) were largely unchanged. Functional measures in olfactory tubercle preparations were made for the first time; both nAChR expression levels and nAChR-mediated functional measures changed differently between striatum and olfactory tubercles. These results show that functional changes measured using synaptosomal [(3) H]-DA release are primarily owing to changes in nAChR, rather than in dopaminergic, function. This study examined dose-response relationships for murine α6β2*-nicotinic acetylcholine receptor (nAChR) down-regulation by chronic nicotine treatment. The ID50 value for α6β2* down-regulation (35 nM) is ≈ 3x lower than the ED50 value for α4β2* nAChR up-regulation (95 nM), both well within the range reached by human smokers. Chronic nicotine treatment altered α6β2*- and α4

  14. 48 CFR 228.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 228.106 Section 228.106 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.106 Administration....

  15. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  16. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  17. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  18. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  19. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  20. 5 CFR 362.101 - Program administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Program administration. 362.101 Section 362.101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS General Provisions § 362.101 Program administration. (a) The Pathways Programs authorized under Executive Order 13562 consist of the...

  1. 7 CFR 868.5 - Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administrator. 868.5 Section 868.5 Agriculture... FOR CERTAIN AGRICULTURAL COMMODITIES Regulations Administration § 868.5 Administrator. The Administrator, under the authority delegated by the Secretary, is charged with administering the programs...

  2. 7 CFR 29.51 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Administration. 29.51 Section 29.51 Agriculture... INSPECTION Regulations Administration § 29.51 Administration. The Director is charged with the supervision of the Division and the performance of all duties assigned thereto in the administration of the...

  3. Chronic administration of aripiprazole activates GSK3β-dependent signalling pathways, and up-regulates GABAA receptor expression and CREB1 activity in rats

    PubMed Central

    Pan, Bo; Huang, Xu-Feng; Deng, Chao

    2016-01-01

    Aripiprazole is a D2-like receptor (D2R) partial agonist with a favourable clinical profile. Previous investigations indicated that acute and short-term administration of aripiprazole had effects on PKA activity, GSK3β-dependent pathways, GABAA receptors, NMDA receptor and CREB1 in the brain. Since antipsychotics are used chronically in clinics, the present study investigated the long-term effects of chronic oral aripiprazole treatment on these cellular signalling pathways, in comparison with haloperidol (a D2R antagonist) and bifeprunox (a potent D2R partial agonist). We found that the Akt-GSK3β pathway was activated by aripiprazole and bifeprunox in the prefrontal cortex; NMDA NR2A levels were reduced by aripiprazole and haloperidol. In the nucleus accumbens, all three drugs increased Akt-GSK3β signalling; in addition, both aripiprazole and haloperidol, but not bifeprunox, increased the expression of Dvl-3, β-catenin and GABAA receptors, NMDA receptor subunits, as well as CREB1 phosphorylation levels. The results suggest that chronic oral administration of aripiprazole affects schizophrenia-related cellular signalling pathways and markers (including Akt-GSK3β signalling, Dvl-GSK3β-β-catenin signalling, GABAA receptor, NMDA receptor and CREB1) in a brain-region-dependent manner; the selective effects of aripiprazole on these signalling pathways might be associated with its unique clinical effects. PMID:27435909

  4. Regulation of hepatic macrophage function by oral administration of xiao-chai-hu-tang (sho-saiko-to, TJ-9) in rats.

    PubMed

    Fujiwara, K; Mochida, S; Nagoshi, S; Iijima, O; Matsuzaki, Y; Takeda, S; Aburada, M

    1995-05-01

    The effect of Xiao-Chai-Hu-Tang (Sho-saiko-to, TJ-9), the extract of a mixture of 7 herbs, on hepatic macrophage function was studied using rats. Hepatic macrophages were activated by injection of Corynebacterium parvum or 70% partial hepatectomy. Oral administration of TJ-9 for 3 weeks did not affect the ability of these macrophages to produce superoxide anions evaluated in situ by liver perfusion with nitro blue tetrazolium (NBT) and phorbol myristate acetate (PMA). However, the similar administration of TJ-9 attenuated the blocking of the activation after partial hepatectomy produced by pretreatment with gum arabic, a polysaccharide of high molecular weight. When gum arabic was added to the medium of rat hepatic macrophages cultured with normal rat sera, their ability to produce superoxide anions was reduced in a dose-related manner. This reduction was attenuated by changing the sera to the sera obtained from rats given oral doses of TJ-9 for 3 weeks. These results suggest that TJ-9 may improve the blocked function of hepatic macrophages in activation. PMID:7650948

  5. 7 CFR 400.56 - Administrative appeal exhaustion.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... contained in 7 CFR part 400, subpart J. Administrative remedies through the appeal process must be exhausted... CORPORATION, DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Actual Production History §...

  6. 7 CFR 400.56 - Administrative appeal exhaustion.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... contained in 7 CFR part 400, subpart J. Administrative remedies through the appeal process must be exhausted... CORPORATION, DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Actual Production History §...

  7. 7 CFR 400.56 - Administrative appeal exhaustion.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... contained in 7 CFR part 400, subpart J. Administrative remedies through the appeal process must be exhausted... CORPORATION, DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Actual Production History §...

  8. 7 CFR 400.56 - Administrative appeal exhaustion.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... contained in 7 CFR part 400, subpart J. Administrative remedies through the appeal process must be exhausted... CORPORATION, DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Actual Production History §...

  9. Early administration of nifedipine protects against angiotensin II-induced cardiomyocyte hypertrophy through regulating CaMKII-SERCA2a pathway and apoptosis in rat cardiomyocytes.

    PubMed

    Luo, Ji; Zhang, Wei-dong; Du, Yi-meng

    2016-04-01

    The calcium channel blocker (CCB), nifedipine, is a more effective treatment for early- than late-stage cardiac hypertrophy. We investigated the effects of early- and late-stage nifedipine administration on calcium homeostasis, CaMKII (Ca(2+) /calmodulin-dependent protein kinase II) activity and apoptosis of cardiomyocytes under hypertrophic stimulation with angiotensin II (AngII). Primary rat cardiomyocytes were divided into five treatment groups: AK, AngII plus the CaMKII inhibitor, KN-93; AN-1 (early-stage), AngII plus nifedipine × 48 h; AN-2 (late-stage), AngII × 48 h, then AngII plus nifedipine × 48 h; C, untreated; and A, AngII × 48 h. The t1/2β [time required for intracellular Ca(2+) concentration ([Ca(2+) ]i) to decline to one half of the peak value] decreased; however, CaMKII and SERCA2a (sarcoplasmic reticulum Ca(2+) -ATPase 2a) activities increased in the AN-1 group compared with the AK group. In the AN-2 group compared with the AN-1 group, CaMKII activity, t1/2α [time required for [Ca(2+) ]i to increase from the bottom to one half of peak value], t1/2β, and apoptosis increased. These results indicate that the timing of CCB administration affects the calcium concentration and apoptosis of hypertrophic cardiomyocytes through the CaMKII-SERCA2a signalling pathway, thereby influencing the drug's protective activity against cardiomyocyte hypertrophy. PMID:26968727

  10. Regulation of Hippocampal Cannabinoid CB1 Receptor Actions by Adenosine A1 Receptors and Chronic Caffeine Administration: Implications for the Effects of Δ9-Tetrahydrocannabinol on Spatial Memory

    PubMed Central

    Sousa, Vasco C; Assaife-Lopes, Natália; Ribeiro, Joaquim A; Pratt, Judith A; Brett, Ros R; Sebastião, Ana M

    2011-01-01

    The cannabinoid CB1 receptor-mediated modulation of γ-aminobutyric acid (GABA) release from inhibitory interneurons is important for the integrity of hippocampal-dependent spatial memory. Although adenosine A1 receptors have a central role in fine-tuning excitatory transmission in the hippocampus, A1 receptors localized in GABAergic cells do not directly influence GABA release. CB1 and A1 receptors are the main targets for the effects of two of the most heavily consumed psychoactive substances worldwide: Δ9-tetrahydrocannabinol (THC, a CB1 receptor agonist) and caffeine (an adenosine receptor antagonist). We first tested the hypothesis that an A1–CB1 interaction influences GABA and glutamate release in the hippocampus. We found that A1 receptor activation attenuated the CB1-mediated inhibition of GABA and glutamate release and this interaction was manifested at the level of G-protein activation. Using in vivo and in vitro approaches, we then investigated the functional implications of the adenosine–cannabinoid interplay that may arise following chronic caffeine consumption. Chronic administration of caffeine in mice (intraperitoneally, 3 mg/kg/day, for 15 days, >12 h before trials) led to an A1-mediated enhancement of the CB1-dependent acute disruptive effects of THC on a short-term spatial memory task, despite inducing a reduction in cortical and hippocampal CB1 receptor number and an attenuation of CB1 coupling with G protein. A1 receptor levels were increased following chronic caffeine administration. This study shows that A1 receptors exert a negative modulatory effect on CB1-mediated inhibition of GABA and glutamate release, and provides the first evidence of chronic caffeine-induced alterations on the cannabinoid system in the cortex and hippocampus, with functional implications in spatial memory. PMID:20927050

  11. Federal Aviation Administration's approach to engine rotor integrity

    NASA Technical Reports Server (NTRS)

    Forney, A. K.

    1977-01-01

    Sections of the U.S. Airworthiness Standards which contribute to rotor integrity are explored. Reports published under NASA's Rotor Burst Protection program are included in current FAA studies to determine the weight penalty for two different levels of increased containment, and the penalty associated with protecting critical structure and systems, the passenger cabin, and the flight deck by strategic location of armor shields or deflector plates. Findings of the two studies will be used to propose revisions to regulations to reduce uncontained rotor failures.

  12. Health Care Financing Administration--Medicare and Medicaid; provider agreements: redesignation and rewrite of Medicare regulations; effective dates; effect of change in ownership. Final rule with comment period.

    PubMed

    1980-04-01

    These regulations revise and redesignate the policies pertaining to provider agreements under the Medicare program to simplify them and to make them easier to read. We have made substantive changes only in the provisions relating to the effective date of the agreement and the effect of a change in ownership. These substantive changes were issued as proposed rulemaking on February 5, 1979, and will also apply to the Medicaid program. The substantive changes make provider agreements effective on the date of the onsite health and safety survey if all Federal requirements are met. If all requirements are not met, the effective date is the date the requirements are met or the date the provider submits an acceptable plan of correction or waiver request. The revised regulations also provide that existing provider agreements be assigned to new owners, subject to the terms and conditions under which they were originally issued. The intent of the substantive changes is to achieve maximum uniformity of policy for the two programs and to provide continuity of coverage for beneficiaries and recipients when there is change of ownership. PMID:10297749

  13. Administrative IT

    ERIC Educational Resources Information Center

    Grayson, Katherine, Ed.

    2006-01-01

    When it comes to Administrative IT solutions and processes, best practices range across the spectrum. Enterprise resource planning (ERP), student information systems (SIS), and tech support are prominent and continuing areas of focus. But widespread change can also be accomplished via the implementation of campuswide document imaging and sharing,…

  14. Database Administrator

    ERIC Educational Resources Information Center

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  15. ADMINISTRATIVE CLIMATE.

    ERIC Educational Resources Information Center

    BRUCE, ROBERT L.; CARTER, G.L., JR.

    IN THE COOPERATIVE EXTENSION SERVICE, STYLES OF LEADERSHIP PROFOUNDLY AFFECT THE QUALITY OF THE SERVICE RENDERED. ACCORDINGLY, MAJOR INFLUENCES ON ADMINISTRATIVE CLIMATE AND EMPLOYEE PRODUCTIVITY ARE EXAMINED IN ESSAYS ON (1) SOURCES OF JOB SATISFACTION AND DISSATISFACTION, (2) MOTIVATIONAL THEORIES BASED ON JOB-RELATED SATISFACTIONS AND NEEDS,…

  16. Engineering Administration.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    This book is intended to acquaint naval engineering officers with their duties in the engineering department. Standard shipboard organizations are analyzed in connection with personnel assignments, division operations, and watch systems. Detailed descriptions are included for the administration of directives, ship's bills, damage control, training…

  17. Oral Administration of Achyranthis radix Extract Prevents TMA-induced Allergic Contact Dermatitis by Regulating Th2 Cytokine and Chemokine Production in Vivo.

    PubMed

    Jung, Sung Keun; Choi, Dae Woon; Kwon, Da-Ae; Kim, Min Jung; Seong, Ki Seung; Shon, Dong-Hwa

    2015-12-03

    Allergic contact dermatitis (ACD) remains a major skin disease in many countries, necessitating the discovery of novel and effective anti-ACD agents. In this study, we investigated the preventive effects of Achyranthis radix extract (AcRE) on trimellitic anhydride (TMA)-induced dermatitis and the potential mechanism of action involved. Oral administration of AcRE and prednisolone (PS) significantly suppressed TMA-induced increases in ear and epidermal thickness, and IgE expression. In addition, abnormal expression of IL-1β and TNF-α protein and mRNA was also significantly attenuated by oral administration of AcRE. Treatment with AcRE also significantly suppressed TMA-induced IL-4 and IL-13 cytokines and mRNA expression in vivo. Moreover, AcRE strongly suppressed TMA-induced IL-4 and IL-5 production in draining lymph nodes, as well as OVA-induced IL-4 and IL-5 expression in primary cultured splenocytes. Interestingly, AcRE suppressed IL-4-induced STAT6 phosphorylation in both primary cultured splenocytes and HaCaT cells, and TMA-induced GATA3 mRNA expression ex vivo. AcRE also suppressed TMA-mediated CCL11 and IL-4-induced CCL26 mRNA expression and infiltration of CCR3 positive cells. The major compounds from AcRE were identified as gentisic acid (0.64 ± 0.2 μg/g dry weight of AcRE), protocatechuic acid (2.69 ± 0.1 μg/g dry weight of AcRE), 4-hydroxybenzoic acid (5.59 ± 0.3 μg/g dry weight of AcRE), caffeic acid (4.21 ± 0.1 μg/g dry weight of AcRE), and ferulic acid (14.78 ± 0.4 ± 0.3 μg/g dry weight of AcRE). Taken together, these results suggest that AcRE has potential for development as an agent to prevent and treat allergic contact dermatitis.

  18. Neuroendocrine control of osmotic regulation in the freshwater shrimp Macrobrachium olfersii (Wiegmann) (Crustacea, decapoda): free amino acid concentrations in the hemolymph.

    PubMed

    Freire, C A; McNamara, J C; Rosa, J C; Greene, L J

    1995-10-01

    The participation of neuroendocrine factors present within the central nervous system in the regulation of hemolymph free amino acid (FAA) concentrations was examined in the freshwater shrimp Macrobrachium olfersii. Test shrimps were injected intramuscularly with homogenates prepared from the eyestalks (ES), ventral nerve cord (VNC), supraesophageal (SEG), or thoracic ganglia (TG) of donor shrimps previously exposed for 6 hr to a high-salinity medium (HSM, 21% salinity). After injection of the homogenate, the shrimps were maintained for up to 6 hr in either freshwater (FW) or HSM. Hemolymph was sampled by cardiac puncture and prepared for reverse phase HPLC, derivatizing the FAA with phenylisothiocyanate. An FAA profile was determined and the [FAA]:[Cl-] ratios for the four FAA present in highest concentration (Gly, Arg, Ala, and Pro for ES and VNC experiments; Glu, Leu, Ala, and Val for SEG and TG experiments) were obtained. Nonparametric analyses revealed specific, notable effects resulting from homogenate injection, e.g., ES homogenate increased [Pro]/[Cl-] ratios in FW-exposed shrimps; SEG homogenate increased [Glu]/[Cl-] and [Val]/[Cl-] ratios in HSM-exposed shrimps; and TG homogenate increased [FAA]/[Cl-] ratios for Glu, Leu, Ala, and Val in HSM-exposed shrimps. Total FAA concentrations decreased after exposure of the shrimps to HSM but were increased by the injection of ES homogenate in FW-exposed shrimps and by TG homogenate in HSM-exposed shrimps. The total [FAA]/[Cl-] ratio was also increased by TG homogenate in HSM-exposed animals. There were no clear effects on [Cl-] alone.(ABSTRACT TRUNCATED AT 250 WORDS)

  19. 48 CFR 27.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Administration of patent... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305 Administration of patent rights clauses....

  20. 48 CFR 27.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Administration of patent... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305 Administration of patent rights clauses....

  1. 48 CFR 27.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Administration of patent... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305 Administration of patent rights clauses....

  2. 48 CFR 27.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Administration of patent... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305 Administration of patent rights clauses....

  3. 48 CFR 27.305 - Administration of patent rights clauses.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Administration of patent... REGULATION GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights under Government Contracts 27.305 Administration of patent rights clauses....

  4. Reported infections after human tissue transplantation before and after new Food and Drug Administration (FDA) regulations, United States, 2001 through June, 2010.

    PubMed

    Mallick, Tarun K; Mosquera, Alexis; Zinderman, Craig E; St Martin, Laura; Wise, Robert P

    2012-06-01

    Processors distributed about 1.5 million human tissue allografts in the U.S. in 2007. The potential for transmitting infections through allografts concerns clinicians and patients. In 2005, FDA implemented Current Good Tissue Practice (CGTP) rules requiring tissue establishments to report to FDA certain serious infections after allograft transplantations. We describe infection reports following tissue transplants received by FDA from 2005 through June, 2010, and compare reporting before and after implementation of CGTP rules. We identified reports received by FDA from January 2001 through June, 2010, for infections in human tissue recipients, examining the reports by tissue type, organism, time to onset, severity, and reporter characteristics. Among 562 reports, 83 (20.8/year) were received from 2001-2004, before the CGTP rules, 43 in the 2005 transition year, and 436 (96.9/year) from 2006 through June, 2010, after the rules. Tissue processors accounted for 84.2% of reports submitted after the rules, compared to 26.5% previously. Bacterial infections were the most commonly reported organisms before (64.6%) and after (62.2%) the new rules. Afterward, 2.5% (11) of reports described deaths, and 33.7% (147) involved hospitalizations. Before the rules, 13% (11) described deaths, and another 72% involved hospitalizations. Reports received by the FDA quadrupled since 2005, suggesting that CGTP regulations have contributed to increased reporting and improved tissue safety surveillance. However, these data do not confirm that the reported infections were caused by suspect tissues; most reports may represent routine post-surgical infections not actually due to allografts.

  5. The "déjà vu effect:" evaluation of United States medical device legislation, regulation, and the Food and Drug Administration's contentious 510(k) program.

    PubMed

    Bauman, Jordan

    2012-01-01

    With the Medical Device Amendments of 1976, Congress granted FDA authority to regulate medical devices by implementing a risk-based regulatory framework. Several years prior to this legislation, the Cooper Committee reviewed the medical device regulatory landscape and uncovered weaknesses that could be detrimental to public health. However, only after several high-profile incidents involving unsafe medical devices did Congress respond with strong legislation. Since 1976, additional medical device legislative revisions have been enacted to address deficiencies highlighted by various groups representing Congress, FDA, and industry. A repetitive conclusion from these groups has been that the 510(k) program is incapable of serving as a premarket evaluation of safety and effectiveness under the existing statutory framework. However, these legislative revisions did not change the statutory framework despite these repeated findings. In 2009, CDRH convened separate groups to again review the 510(k) program. While more comprehensive than previous initiatives, the observed deficiencies and the proposed recommendations are remarkably similar to those identified by their predecessors. This cyclical review of the medical device regulatory landscape whereby the same observations and recommendations are repeated yet the output of such review does not yield major legislative revision of the existing statutory framework can be described as the "déjà vu effect." This will continue unless Congress enacts legislation that implements a new statutory framework with a different standard other than substantial equivalence. In the past, Congress has implemented major legislation only after a public health crisis. Hopefully this will not be the driving force in the future.

  6. 32 CFR 700.722 - Administration and discipline: Staff unassigned to an administrative command.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Administration and discipline: Staff unassigned... REGULATIONS AND OFFICIAL RECORDS Commanders In Chief and Other Commanders Administration and Discipline § 700.722 Administration and discipline: Staff unassigned to an administrative command. (a) When it is...

  7. 32 CFR 700.722 - Administration and discipline: Staff unassigned to an administrative command.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Administration and discipline: Staff unassigned... REGULATIONS AND OFFICIAL RECORDS Commanders In Chief and Other Commanders Administration and Discipline § 700.722 Administration and discipline: Staff unassigned to an administrative command. (a) When it is...

  8. 32 CFR 700.722 - Administration and discipline: Staff unassigned to an administrative command.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Administration and discipline: Staff unassigned... REGULATIONS AND OFFICIAL RECORDS Commanders In Chief and Other Commanders Administration and Discipline § 700.722 Administration and discipline: Staff unassigned to an administrative command. (a) When it is...

  9. 32 CFR 700.722 - Administration and discipline: Staff unassigned to an administrative command.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Administration and discipline: Staff unassigned... REGULATIONS AND OFFICIAL RECORDS Commanders In Chief and Other Commanders Administration and Discipline § 700.722 Administration and discipline: Staff unassigned to an administrative command. (a) When it is...

  10. 32 CFR 700.722 - Administration and discipline: Staff unassigned to an administrative command.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Administration and discipline: Staff unassigned... REGULATIONS AND OFFICIAL RECORDS Commanders In Chief and Other Commanders Administration and Discipline § 700.722 Administration and discipline: Staff unassigned to an administrative command. (a) When it is...

  11. Direct and long-lasting effects elicited by repeated drug administration on 50-kHz ultrasonic vocalizations are regulated differently: implications for the study of the affective properties of drugs of abuse.

    PubMed

    Simola, Nicola; Frau, Lucia; Plumitallo, Antonio; Morelli, Micaela

    2014-03-01

    Several studies suggest that 50-kHz ultrasonic vocalizations (USVs) may indicate a positive affective state in rats, and these vocalizations are increasingly being used to investigate the properties of psychoactive drugs. Previous studies, however, have focused on dopaminergic psychostimulants and morphine, whereas little is known about how other drugs modulate 50-kHz USVs. To further elucidate the neuropharmacology of 50-kHz USVs, the present study characterized the direct and long-lasting effects of different drugs of abuse, by measuring the number of 50-kHz USVs and their 'trill' subtype emitted by adult male rats. Rats received repeated administrations of amphetamine (2 mg/kg, i.p.), 3,4-methylenedioxymethamphetamine (MDMA, 7.5 mg/kg, i.p.), morphine (7.5 mg/kg, s.c.), or nicotine (0.4 mg/kg, s.c.), on either consecutive or alternate days (five administrations in total) in a novel environment. Seven days later, rats were re-exposed to the drug-paired environment, subjected to USVs recording, and then challenged with the same drug. Finally, 7 d after the challenge, rats were repeatedly exposed to the drug-paired environment and vocalizations were measured. Amphetamine was the only drug to stimulate 50-kHz USVs and 'trill' subtype emission during administration and challenge. Conversely, all rats emitted 50-kHz USVs when re-exposed to the test cage, and this effect was most marked in morphine-treated rats, and less evident in nicotine-treated rats. This study demonstrates that the direct and long-lasting effects of drugs on 50-kHz USVs are regulated differently, providing a better understanding of the usefulness of these vocalizations in the study of psychoactive drugs.

  12. Direct and long-lasting effects elicited by repeated drug administration on 50-kHz ultrasonic vocalizations are regulated differently: implications for the study of the affective properties of drugs of abuse.

    PubMed

    Simola, Nicola; Frau, Lucia; Plumitallo, Antonio; Morelli, Micaela

    2014-03-01

    Several studies suggest that 50-kHz ultrasonic vocalizations (USVs) may indicate a positive affective state in rats, and these vocalizations are increasingly being used to investigate the properties of psychoactive drugs. Previous studies, however, have focused on dopaminergic psychostimulants and morphine, whereas little is known about how other drugs modulate 50-kHz USVs. To further elucidate the neuropharmacology of 50-kHz USVs, the present study characterized the direct and long-lasting effects of different drugs of abuse, by measuring the number of 50-kHz USVs and their 'trill' subtype emitted by adult male rats. Rats received repeated administrations of amphetamine (2 mg/kg, i.p.), 3,4-methylenedioxymethamphetamine (MDMA, 7.5 mg/kg, i.p.), morphine (7.5 mg/kg, s.c.), or nicotine (0.4 mg/kg, s.c.), on either consecutive or alternate days (five administrations in total) in a novel environment. Seven days later, rats were re-exposed to the drug-paired environment, subjected to USVs recording, and then challenged with the same drug. Finally, 7 d after the challenge, rats were repeatedly exposed to the drug-paired environment and vocalizations were measured. Amphetamine was the only drug to stimulate 50-kHz USVs and 'trill' subtype emission during administration and challenge. Conversely, all rats emitted 50-kHz USVs when re-exposed to the test cage, and this effect was most marked in morphine-treated rats, and less evident in nicotine-treated rats. This study demonstrates that the direct and long-lasting effects of drugs on 50-kHz USVs are regulated differently, providing a better understanding of the usefulness of these vocalizations in the study of psychoactive drugs. PMID:24138707

  13. 29 CFR 100.614 - Collection by administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 2 2010-07-01 2010-07-01 false Collection by administrative offset. 100.614 Section 100.614 Labor Regulations Relating to Labor NATIONAL LABOR RELATIONS BOARD ADMINISTRATIVE REGULATIONS Debt Collection Procedures § 100.614 Collection by administrative offset. (a) Application. (1) The NLRB may administratively undertake collection...

  14. 7 CFR 253.4 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 4 2011-01-01 2011-01-01 false Administration. 253.4 Section 253.4 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM FOR HOUSEHOLDS ON INDIAN RESERVATIONS §...

  15. 7 CFR 253.4 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 4 2013-01-01 2013-01-01 false Administration. 253.4 Section 253.4 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM FOR HOUSEHOLDS ON INDIAN RESERVATIONS §...

  16. 48 CFR 1028.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1028.106 Section 1028.106 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 1028.106 Administration....

  17. 7 CFR 1434.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1434.2 Section 1434.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... FOR HONEY § 1434.2 Administration. (a) The regulations of this part shall be administered under...

  18. 7 CFR 1469.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1469.2 Section 1469.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. (a) The regulations in this part will be administered under the general supervision and...

  19. 48 CFR 1328.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1328.106 Section 1328.106 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 1328.106 Administration....

  20. 48 CFR 828.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 828.106 Section 828.106 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 828.106 Administration....

  1. 48 CFR 428.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Administration. 428.106 Section 428.106 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 428.106 Administration....

  2. 7 CFR 735.400 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 735.400 Section 735.400 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. This subpart sets forth the regulations under which DACO may authorize one or more...

  3. 7 CFR 735.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 735.2 Section 735.2 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. (a) FSA will administer all provisions and activities regulated under the Act under the...

  4. 7 CFR 625.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 625.3 Section 625.3 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.3 Administration. (a) The regulations...

  5. 7 CFR 1400.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1400.2 Section 1400.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.2 Administration. (a) The regulations...

  6. 48 CFR 2828.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Administration. 2828.106 Section 2828.106 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General Contracting Requirements BONDS AND INSURANCE Bonds 2828.106 Administration....

  7. 48 CFR 1228.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1228.106 Section 1228.106 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 1228.106 Administration....

  8. 24 CFR 594.25 - Project administration.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 3 2011-04-01 2010-04-01 true Project administration. 594.25 Section 594.25 Housing and Urban Development Regulations Relating to Housing and Urban Development... Grant Amounts § 594.25 Project administration. Project administration will be governed by the terms...

  9. 24 CFR 594.25 - Project administration.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 3 2013-04-01 2013-04-01 false Project administration. 594.25 Section 594.25 Housing and Urban Development Regulations Relating to Housing and Urban Development... Grant Amounts § 594.25 Project administration. Project administration will be governed by the terms...

  10. 24 CFR 594.25 - Project administration.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 3 2014-04-01 2013-04-01 true Project administration. 594.25 Section 594.25 Housing and Urban Development Regulations Relating to Housing and Urban Development... Grant Amounts § 594.25 Project administration. Project administration will be governed by the terms...

  11. 24 CFR 594.25 - Project administration.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 3 2012-04-01 2012-04-01 false Project administration. 594.25 Section 594.25 Housing and Urban Development Regulations Relating to Housing and Urban Development... Grant Amounts § 594.25 Project administration. Project administration will be governed by the terms...

  12. 46 CFR 296.50 - Administrative determinations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Administrative determinations. 296.50 Section 296.50 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND OPERATORS MARITIME SECURITY PROGRAM (MSP) Appeals Procedures § 296.50 Administrative determinations. (a) Policy. A Contractor who disagrees...

  13. 7 CFR 1205.11 - Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... Procedures for Conduct of Sign-up Period Definitions § 1205.11 Administrator. The term Administrator means the Administrator of the Agricultural Marketing Service, or any officer or employee of USDA to...

  14. 46 CFR 296.50 - Administrative determinations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Administrative determinations. 296.50 Section 296.50 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND..., Scott Air Force Base, IL 62225-5357. (c) Process. The Administrator, or the Commander in the case of...

  15. 12 CFR 360.4 - Administrative expenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Administrative expenses. 360.4 Section 360.4 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY RESOLUTION AND RECEIVERSHIP RULES § 360.4 Administrative expenses. The priority for administrative...

  16. 7 CFR 633.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 633.3 Section 633.3 Agriculture... AGRICULTURE LONG TERM CONTRACTING WATER BANK PROGRAM § 633.3 Administration. (a) The regulations in this part... administration and related policy matters. No determination by the State Technical Committee shall compel...

  17. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....

  18. 24 CFR 594.25 - Project administration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Project administration. 594.25 Section 594.25 Housing and Urban Development Regulations Relating to Housing and Urban Development... Grant Amounts § 594.25 Project administration. Project administration will be governed by the terms...

  19. 49 CFR 510.6 - Administrative depositions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 6 2011-10-01 2011-10-01 false Administrative depositions. 510.6 Section 510.6 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMATION GATHERING POWERS § 510.6 Administrative depositions....

  20. 49 CFR 510.6 - Administrative depositions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Administrative depositions. 510.6 Section 510.6 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMATION GATHERING POWERS § 510.6 Administrative depositions....

  1. 48 CFR 30.607 - Subcontract administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Administration 30.607 Subcontract administration. When a negotiated CAS price adjustment or a determination of noncompliance is required at the... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontract...

  2. 45 CFR 1703.501 - Administrative Review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Administrative Review. 1703.501 Section 1703.501 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE GOVERNMENT IN THE SUNSHINE ACT Administrative Review § 1703.501 Administrative Review....

  3. 5 CFR 362.301 - Program administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Program administration. 362.301 Section 362.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS... an entry-level developmental experience designed to lead to a civil service career in the...

  4. 5 CFR 362.301 - Program administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Program administration. 362.301 Section 362.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS... an entry-level developmental experience designed to lead to a civil service career in the...

  5. 45 CFR 1703.501 - Administrative Review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 4 2012-10-01 2012-10-01 false Administrative Review. 1703.501 Section 1703.501 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE GOVERNMENT IN THE SUNSHINE ACT Administrative Review § 1703.501 Administrative Review....

  6. Compliance with High-Intensity Radiated Fields Regulations - Emitter's Perspective

    NASA Technical Reports Server (NTRS)

    Statman, Joseph; Jamnejad, Vahraz; Nguyen, Lee

    2012-01-01

    NASA's Deep Space Network (DSN) uses high-power transmitters on its large antennas to communicate with spacecraft of NASA and its partner agencies. The prime reflectors of the DSN antennas are parabolic, at 34m and 70m in diameter. The DSN transmitters radiate Continuous Wave (CW) signals at 20 kW - 500 kW at X-band and S-band frequencies. The combination of antenna reflector size and high frequency results in a very narrow beam with extensive oscillating near-field pattern. Another unique feature of the DSN antennas is that they (and the radiated beam) move mostly at very slow sidereal rate, essentially identical in magnitude and at the opposite direction of Earth rotation.The DSN is in the process of revamping its documentation to provide analysis of the High Intensity Radiation Fields (HIRF) environment resulting from radio frequency radiation from DSN antennas for comparison to FAA regulations regarding certification of HIRF protection as outlined in the FAA regulations on HIRF protection for aircraft electrical and electronic systems (Title 14, Code of Federal Regulations (14 CFR) [section sign][section sign] 23.1308, 25.1317, 27.1317, and 29.1317).This paper presents work done at JPL, in consultation with the FAA. The work includes analysis of the radiated field structure created by the unique DSN emitters (combination of transmitters and antennas) and comparing it to the fields defined in the environments in the FAA regulations. The paper identifies areas that required special attention, including the implications of the very narrow beam of the DSN emitters and the sidereal rate motion. The paper derives the maximum emitter power allowed without mitigation and the mitigation zones, where required.Finally, the paper presents summary of the results of the analyses of the DSN emitters and the resulting DSN process documentation.

  7. Solvent microextraction-flame atomic absorption spectrometry (SME-FAAS) for determination of ultratrace amounts of cadmium in meat and fish samples.

    PubMed

    Goudarzi, Nasser

    2009-02-11

    A simple, low cost and highly sensitive method based on solvent microextraction (SME) for separation/preconcentration and flame atomic absorption spectrometry (FAAS) was proposed for the determination of ultratrace amounts of cadmium in meat and fish samples. The analytical procedure involved the formation of a hydrophobic complex by mixing the analyte solution with an ammonium pyrrolidinedithiocarbamate (APDC) solution. In suitable conditions, the complex of cadmium-APDC entered the micro organic phase, and thus, separation of the analyte from the matrix was achieved. Under optimal chemical and instrumental conditions, a detection limit (3 sigma) of 0.8 ng L(-1) and an enrichment factor of 93 were achieved. The relative standard deviation for the method was found to be 2.2% for Cd. The interference effects of some anions and cations were also investigated. The developed method has been applied to the determination of trace Cd in meat and fish samples. PMID:19138082

  8. Determination of cadmium in alcohol fuel using Moringa oleifera seeds as a biosorbent in an on-line system coupled to FAAS.

    PubMed

    Alves, Vanessa Nunes; Mosquetta, Rafael; Coelho, Nívia Maria Melo; Bianchin, Joyce Nunes; Di Pietro Roux, Kalya Cravo; Martendal, Edmar; Carasek, Eduardo

    2010-01-15

    In this study a new method for determination of cadmium in alcohol fuel using Moringa oleifera seeds as a biosorbent in an on-line preconcentration system coupled to flame atomic absorption spectrometry (FAAS) was developed. Flow and chemical variables of the proposed system were optimized through multivariate designs. The limit of detection for cadmium was 5.50microg L(-1) and the precision was below 2.3% (35.0microg L(-1), n=9). The analytical curve was linear from 5 to 150microg L(-1), with a correlation coefficient of 0.9993. The developed method was successfully applied to spiked alcohol fuel, and accuracy was assessed through recovery tests, with recovery ranging from 97.50 to 100%. PMID:20006064

  9. Application of High Resolution-Continuum Source Flame Atomic Absorption Spectrometry (HR-CS FAAS): determination of trace elements in tea and tisanes.

    PubMed

    Paz-Rodríguez, Beatriz; Domínguez-González, María Raquel; Aboal-Somoza, Manuel; Bermejo-Barrera, Pilar

    2015-03-01

    A new application of HR-CS FAAS (High Resolution-Continuum Source Flame Atomic Absorption Spectrometry) has been developed for the determination of several trace elements (Ca, Co, Cu, Fe, Mn, Ni, Na and Zn) in infusions made from tea, rooibos and tea with seaweed samples. The proposed methods are fast, inexpensive and show good performances: the mean analytical recovery was approximately 100%. The mean limit of detection was 29.4 μg/l, and the mean limit of quantification was 98.0 μg/l (both limits refer to the brewed samples). Due to the matrix effect observed, the standard addition method had to be applied. Preliminary classification (based on metal contents) using chemometric techniques such as PCA (Principal Component Analysis) and CA (Cluster Analysis), was successful for infusions made from rooibos and tea with seaweed, but inconclusive for black and green teas.

  10. Application of High Resolution-Continuum Source Flame Atomic Absorption Spectrometry (HR-CS FAAS): determination of trace elements in tea and tisanes.

    PubMed

    Paz-Rodríguez, Beatriz; Domínguez-González, María Raquel; Aboal-Somoza, Manuel; Bermejo-Barrera, Pilar

    2015-03-01

    A new application of HR-CS FAAS (High Resolution-Continuum Source Flame Atomic Absorption Spectrometry) has been developed for the determination of several trace elements (Ca, Co, Cu, Fe, Mn, Ni, Na and Zn) in infusions made from tea, rooibos and tea with seaweed samples. The proposed methods are fast, inexpensive and show good performances: the mean analytical recovery was approximately 100%. The mean limit of detection was 29.4 μg/l, and the mean limit of quantification was 98.0 μg/l (both limits refer to the brewed samples). Due to the matrix effect observed, the standard addition method had to be applied. Preliminary classification (based on metal contents) using chemometric techniques such as PCA (Principal Component Analysis) and CA (Cluster Analysis), was successful for infusions made from rooibos and tea with seaweed, but inconclusive for black and green teas. PMID:25306375

  11. [FI-KR non-separated method coupled with FAAS for the determination of Fe(II) and Fe(III) in water].

    PubMed

    Wang, Zhong-yuan; Zhang, Hong-kang; Fang, Hong-da; Su, Yao-dong; Mittal, Gauri S

    2012-03-01

    An FI-KR non-separated method coupled with FAAS for the determination of Fe(II) and Fe(III) was developed. With 60 s of sampling at a flow rate of 6.0 mL x min(-1), EF of 41 for Fe(III) and 9 for Fe(II) were obtained. The precision (RSD, n = 11) for Fe(III) and Fe(II) was 2.3% and 3.1% at the 0.04 mg x L(-1) level respectively. When 0.1 per thousand phi TEA was used as masking reagent, the recovery rate for Fe(III) and Fe(II) was from 97% to 101% and from 96% to 100% respectively.

  12. Determination of heavy metals at sub-ppm levels in seawater and dialysis solutions by FAAS after tetrakis(pyridine)-nickel(II)bis(thiocyanate) coprecipitation.

    PubMed

    Sahin, Uğur; Kartal, Senol; Ulgen, Ahmet

    2008-06-01

    A coprecipitation method has been developed for the determination of Cr(III), Mn(II), Fe(III), Co(II), Cu(II), Cd(II) and Pb(II) ions in aqueous samples by flame atomic absorption spectrometry (FAAS) with the combination of pyridine, nickel(II) as a carrier element and potassium thiocyanate as an auxiliary complexing agent. The obtained coprecipitates were dissolved with nitric acid and measured by FAAS. The coprecipitation conditions, such as the effect of the pH, amounts of nickel, pyridine and potassium thiocyanate, sample volume, and the standing time of the precipitate formation were examined in detail. It was found that the metal ions studied were quantitatively coprecipitated with tetrakis(pyridine)-nickel(II)bis(thiocyanate) precipitate (TP-Ni-BT) in the pH range of 9.0 - 10.5. The reliability of the results was evaluated by recovery tests, using synthetic seawater solutions spiked with the analyte metal ions. The obtained recoveries ranged from 96 to 101% for all of the metal ions investigated. The proposed method was validated by analyses of two certified reference materials (NIST SRM 2711 Montana soil and HPS Certified Waste Water Trace Metals Lot #D532205). It was also successfully applied to seawater and dialysis solution samples. The detection limits (n = 25, 3s) were in the range of 0.01-2.44 microg l(-1) for the studied elements and the relative standard deviations were < or =6%, which indicated that this method could fully satisfy the requirements for analysis of such samples as seawater and dialysis solution having high salt contents. PMID:18544864

  13. 75 FR 45104 - Information Collection Requirement; Defense Federal Acquisition Regulation Supplement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... Regulation Supplement; Administrative Matters AGENCY: Defense Acquisition Regulations System, Department of... Federal Acquisition Regulation Supplement (DFARS) Part 204, Administrative Matters, and related clauses...

  14. 5 CFR 550.1301 - Purpose, applicability, and administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... administration. 550.1301 Section 550.1301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Firefighter Pay § 550.1301 Purpose, applicability, and administration... subpart applies to any firefighter as defined in § 550.1302. (c) Administration. The head of an...

  15. 5 CFR 550.1301 - Purpose, applicability, and administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... administration. 550.1301 Section 550.1301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Firefighter Pay § 550.1301 Purpose, applicability, and administration... subpart applies to any firefighter as defined in § 550.1302. (c) Administration. The head of an...

  16. 5 CFR 179.309 - Additional administrative procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Additional administrative procedures. 179.309 Section 179.309 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Administrative Offset § 179.309 Additional administrative procedures....

  17. 5 CFR 550.401 - Purpose, applicability, authority, and administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Purpose, applicability, authority, and administration. 550.401 Section 550.401 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PAY ADMINISTRATION (GENERAL) Payments During Evacuation § 550.401 Purpose, applicability, authority, and administration....

  18. Circadian regulation of food-anticipatory activity in molecular clock-deficient mice.

    PubMed

    Takasu, Nana N; Kurosawa, Gen; Tokuda, Isao T; Mochizuki, Atsushi; Todo, Takeshi; Nakamura, Wataru

    2012-01-01

    In the mammalian brain, the suprachiasmatic nucleus (SCN) of the anterior hypothalamus is considered to be the principal circadian pacemaker, keeping the rhythm of most physiological and behavioral processes on the basis of light/dark cycles. Because restriction of food availability to a certain time of day elicits anticipatory behavior even after ablation of the SCN, such behavior has been assumed to be under the control of another circadian oscillator. According to recent studies, however, mutant mice lacking circadian clock function exhibit normal food-anticipatory activity (FAA), a daily increase in locomotor activity preceding periodic feeding, suggesting that FAA is independent of the known circadian oscillator. To investigate the molecular basis of FAA, we examined oscillatory properties in mice lacking molecular clock components. Mice with SCN lesions or with mutant circadian periods were exposed to restricted feeding schedules at periods within and outside circadian range. Periodic feeding led to the entrainment of FAA rhythms only within a limited circadian range. Cry1(-/-) mice, which are known to be a "short-period mutant," entrained to a shorter period of feeding cycles than did Cry2(-/-) mice. This result indicated that the intrinsic periods of FAA rhythms are also affected by Cry deficiency. Bmal1(-/-) mice, deficient in another essential element of the molecular clock machinery, exhibited a pre-feeding increase of activity far from circadian range, indicating a deficit in circadian oscillation. We propose that mice possess a food-entrainable pacemaker outside the SCN in which canonical clock genes such as Cry1, Cry2 and Bmal1 play essential roles in regulating FAA in a circadian oscillatory manner.

  19. Co-administration of the mTORC1/TORC2 inhibitor INK128 and the Bcl-2/Bcl-xL antagonist ABT-737 kills human myeloid leukemia cells through Mcl-1 down-regulation and AKT inactivation

    PubMed Central

    Rahmani, Mohamed; Aust, Mandy Mayo; Hawkins, Elisa; Parker, Rebecca E.; Ross, Masey; Kmieciak, Maciej; Reshko, Leonid Borisovich; Rizzo, Kathryn A.; Dumur, Catherine I.; Ferreira-Gonzalez, Andrea; Grant, Steven

    2015-01-01

    Effects of concurrent inhibition of mTORC1/2 and Bcl-2/Bcl-xL in human acute myeloid leukemia cells were examined. Tetracycline-inducible Bcl-2/Bcl-xL dual knockdown markedly sensitized acute myeloid leukemia cells to the dual TORC1/2 inhibitor INK128 in vitro as well as in vivo. Moreover, INK128 co-administered with the Bcl-2/xL antagonist ABT-737 sharply induced cell death in multiple acute myeloid leukemia cell lines, including TKI-resistant FLT3-ITD mutants and primary acute myeloid leukemia blasts carrying various genetic aberrations e.g., FLT3, IDH2, NPM1, and Kras, while exerting minimal toxicity toward normal hematopoietic CD34+ cells. Combined treatment was particularly active against CD34+/CD38−/CD123+ primitive leukemic progenitor cells. The INK128/ABT-737 regimen was also effective in the presence of a protective stromal microenvironment. Notably, INK128 was more potent than the TORC1 inhibitor rapamycin in down-regulating Mcl-1, diminishing AKT and 4EBP1 phosphorylation, and potentiating ABT-737 activity. Mcl-1 ectopic expression dramatically attenuated INK128/ABT-737 lethality, indicating an important functional role for Mcl-1 down-regulation in INK128/ABT-737 actions. Immunoprecipitation analysis revealed that combined treatment markedly diminished Bax, Bak, and Bim binding to all major anti-apoptotic Bcl-2 members (Bcl-2/Bcl-xL/Mcl-1), while Bax/Bak knockdown reduced cell death. Finally, INK128/ABT-737 co-administration sharply attenuated leukemia growth and significantly prolonged survival in a systemic acute myeloid leukemia xenograft model. Analysis of subcutaneous acute myeloid leukemia-derived tumors revealed significant decrease in 4EBP1 phosphorylation and Mcl-1 protein level, consistent with results obtained in vitro. These findings demonstrate that co-administration of dual mTORC1/mTORC2 inhibitors and BH3-mimetics exhibits potent anti-leukemic activity in vitro and in vivo, arguing that this strategy warrants attention in acute myeloid

  20. 48 CFR 1442.202 - Assignment of contract administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Assignment of contract administration. (a) The decision to withhold normal individual contract administration... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Assignment of contract administration. 1442.202 Section 1442.202 Federal Acquisition Regulations System DEPARTMENT OF THE...

  1. 50 CFR 402.04 - Counterpart regulations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.04 Counterpart regulations....

  2. 50 CFR 402.04 - Counterpart regulations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.04 Counterpart regulations....

  3. 50 CFR 402.04 - Counterpart regulations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.04 Counterpart regulations....

  4. 50 CFR 402.04 - Counterpart regulations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.04 Counterpart regulations....

  5. 50 CFR 402.04 - Counterpart regulations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE); ENDANGERED SPECIES COMMITTEE REGULATIONS SUBCHAPTER A INTERAGENCY COOPERATION-ENDANGERED SPECIES ACT OF 1973, AS AMENDED General § 402.04 Counterpart regulations....

  6. Use of High-Resolution Continuum Source Flame Atomic Absorption Spectrometry (HR-CS FAAS) for Sequential Multi-Element Determination of Metals in Seawater and Wastewater Samples

    NASA Astrophysics Data System (ADS)

    Peña-Vázquez, E.; Barciela-Alonso, M. C.; Pita-Calvo, C.; Domínguez-González, R.; Bermejo-Barrera, P.

    2015-09-01

    The objective of this work is to develop a method for the determination of metals in saline matrices using high-resolution continuum source flame atomic absorption spectrometry (HR-CS FAAS). Module SFS 6 for sample injection was used in the manual mode, and flame operating conditions were selected. The main absorption lines were used for all the elements, and the number of selected analytical pixels were 5 (CP±2) for Cd, Cu, Fe, Ni, Pb and Zn, and 3 pixels for Mn (CP±1). Samples were acidified (0.5% (v/v) nitric acid), and the standard addition method was used for the sequential determination of the analytes in diluted samples (1:2). The method showed good precision (RSD(%) < 4%, except for Pb (6.5%)) and good recoveries. Accuracy was checked after the analysis of an SPS-WW2 wastewater reference material diluted with synthetic seawater (dilution 1:2), showing a good agreement between certified and experimental results.

  7. Direct Zinc Determination in Brazilian Sugar Cane Spirit by Solid-Phase Extraction Using Moringa oleifera Husks in a Flow System with Detection by FAAS

    PubMed Central

    Alves, Vanessa N.; Borges, Simone S. O.; Coelho, Nivia M. M.

    2011-01-01

    This paper reports a method for the determination of zinc in Brazilian sugar cane spirit, (cachaça in Portuguese), using solid-phase extraction with a flow injection analysis system and detection by FAAS. The sorbent material used was activated carbon obtained from Moringa oleifera husks. Flow and chemical variables of the proposed system were optimized through multivariate designs. The factors selected were sorbent mass, sample pH, sample flow rate, and eluent concentration. The optimum extraction conditions were obtained using a sample pH of 4.0, a sample flow rate of 6.0 mL min−1, 30.0 mg of sorbent mass, and 1.0 mol L−1 HNO3 as the eluent at a flow rate of 4.0 mL min−1. The limit of detection for zinc was 1.9 μg L−1, and the precision was below 0.82% (20.0 μg L−1, n = 7). The analytical curve was linear from 2 to 50 μg L−1, with a correlation coefficient of 0.9996. The method developed was successfully applied to spiked Brazilian sugar cane spirit, and accuracy was assessed through recovery tests, with results ranging from 83% to 100%. PMID:21785595

  8. 75 FR 16345 - Administrative Practices and Procedures; Good Guidance Practices; Technical Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-01

    ..., 301-827-7010. SUPPLEMENTARY INFORMATION: FDA is amending its administrative regulations in 21 CFR part.... 10.90 Food and Drug Administration regulations, recommendations, and agreements. (a) Regulations. FDA... Administration, HHS. ACTION: Final rule; technical amendment. SUMMARY: The Food and Drug Administration (FDA)...

  9. Senior Administrators Should Have Administrative Contracts.

    ERIC Educational Resources Information Center

    Posner, Gary J.

    1987-01-01

    Recognizing that termination is viewed by the employee as the equivalent to capital punishment of a career, an administrative contract can reduce the emotional and financial entanglements that often result. Administrative contracts are described. (MLW)

  10. Small Business Administration Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... businesses. Timetable: Action Date FR Cite NPRM 08/00/10 Regulatory Flexibility Analysis Required: Yes Agency... Manufacturing Assistance Act of 2004 (Reauthorization Act) to regulate Small Business Lending Companies (SBLCs... Part XVI Small Business Administration Semiannual Regulatory Agenda ] SMALL...

  11. 48 CFR 46.104 - Contract administration office responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract administration office responsibilities. 46.104 Section 46.104 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE General 46.104 Contract administration...

  12. 27 CFR 26.3 - Delegations of the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 1135.26, Delegation of the Administrator's Authorities in 27 CFR Part 26, Liquors and Articles From... Administrator. 26.3 Section 26.3 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Regulations § 26.3 Delegations of the Administrator. The regulatory authorities of the Administrator...

  13. 27 CFR 29.42 - Delegations of the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the Administrator's Authorities in 27 CFR Part 29, Stills and Miscellaneous Regulations. You may... Administrator. 29.42 Section 29.42 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... Delegations of the Administrator. The regulatory authorities of the Administrator contained in this part...

  14. 46 CFR 390.6 - Administration of the agreement.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Administration of the agreement. 390.6 Section 390.6 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS UNDER PUBLIC LAW 91-469 CAPITAL CONSTRUCTION FUND § 390.6 Administration of the agreement. (a) In general. The Maritime Administrator...

  15. 46 CFR 390.6 - Administration of the agreement.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Administration of the agreement. 390.6 Section 390.6 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS UNDER PUBLIC LAW 91-469 CAPITAL CONSTRUCTION FUND § 390.6 Administration of the agreement. (a) In general. The Maritime Administrator...

  16. 46 CFR 5.19 - Administrative Law Judge.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Administrative Law Judge. 5.19 Section 5.19 Shipping... REGULATIONS-PERSONNEL ACTION Definitions § 5.19 Administrative Law Judge. (a) An Administrative Law Judge... has delegated to Administrative Law Judges the authority to admonish, suspend, with or...

  17. 46 CFR 5.19 - Administrative Law Judge.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Administrative Law Judge. 5.19 Section 5.19 Shipping... REGULATIONS-PERSONNEL ACTION Definitions § 5.19 Administrative Law Judge. (a) An Administrative Law Judge... has delegated to Administrative Law Judges the authority to admonish, suspend, with or...

  18. 5 CFR 930.205 - Administrative law judge pay system.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Administrative law judge pay system. 930.205 Section 930.205 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) PROGRAMS FOR SPECIFIC POSITIONS AND EXAMINATIONS (MISCELLANEOUS) Administrative...

  19. 5 CFR 930.205 - Administrative law judge pay system.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Administrative law judge pay system. 930.205 Section 930.205 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) PROGRAMS FOR SPECIFIC POSITIONS AND EXAMINATIONS (MISCELLANEOUS) Administrative...

  20. 7 CFR 1.343 - Right to administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Right to administrative offset. 1.343 Section 1.343 Agriculture Office of the Secretary of Agriculture ADMINISTRATIVE REGULATIONS Procedures Related to Administrative Hearings Under the Program Fraud Civil Remedies Act of 1986 § 1.343 Right to administrative...