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Sample records for administration faa regulations

  1. 41 CFR 102-37.535 - What information must FAA provide to GSA on its administration of the public airport donation...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FAA provide to GSA on its administration of the public airport donation program? 102-37.535 Section... (Continued) FEDERAL MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.535 What information must FAA provide to GSA on its administration...

  2. FAA (Federal Aviation Administration) Air Traffic Activity FY 1986.

    DTIC Science & Technology

    1986-09-30

    AIRPORTS WITH FAA-3PSRATEO TRAFIC CONTROL TVWERS RY STATE (CONTINUED) STAT? AND LOCATION U AIR AI6 GENERAL LOCATION NAME IENTIFIPR 8 TOTAL CARRISR...0 0 0 LINUE "I 1 ZM4 3497 1273 99 74 251 LIMA ALLEN COUNTY 31 N ZI0 17 0 2 15 3LINCNFIELO IL N iC 4 0 0 4 2 LINCOLN LOGAN COUNTY IL S I S*I 9 0 0 9 0...VIRGINIA LENISBURG GREENBRIER ELWIS N 2100. %v TABLE n FISCAL YEAR 196 OPEIRATIONS AT AtFPORTS WITN CONTIRACTOR-3PERATED TRAFIC C0N11)L VtflERS BY STATE

  3. 14 CFR 11.29 - May FAA change its regulations without first issuing an ANPRM or NPRM?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false May FAA change its regulations without first issuing an ANPRM or NPRM? 11.29 Section 11.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES GENERAL RULEMAKING PROCEDURES Rulemaking...

  4. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  5. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  6. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  7. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  8. 14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under...

  9. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of... responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and...

  10. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of... responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and...

  11. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of... responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and...

  12. 41 CFR 102-75.405 - What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and a copy of... responsibilities does the Federal Aviation Administration (FAA) have after receiving a copy of the notice (and...

  13. 14 CFR 11.21 - What are the most common kinds of rulemaking actions for which FAA follows the Administrative...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false What are the most common kinds of rulemaking actions for which FAA follows the Administrative Procedure Act? 11.21 Section 11.21 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES...

  14. 77 FR 4219 - FAA-Approved Portable Oxygen Concentrators; Technical Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Federal Aviation Administration 14 CFR Part 121 FAA-Approved Portable Oxygen Concentrators; Technical...: The FAA is amending regulations relating to operating rules for FAA approved portable oxygen... Certain Portable Oxygen Concentrator Devices Onboard Aircraft'' (70 FR 40156). SFAR 106 permits...

  15. HEMP (High-Altitude Electromagnetic Pulse) validation of FAA (Federal Aviation Administration) radio facility

    NASA Astrophysics Data System (ADS)

    Sanders, Stephen C.

    1989-05-01

    The Harry Diamond Lab. provided high-altitude electromagnetic pulse (HEMP) and partial lightning hardness verification testing to a high-frequency radio facility for the FAA. The facility consisted of a shielded enclosure with antennas and cables connected through protective devices at the shield to dummy loads within the shield. It was exposed to low-level radiation with measurements of internal fields extrapolated to threat levels and compared to specific criteria. Each typical penetration was injected with a simulated lightning source, and internal measurements were compared to specific criteria. Although criteria were not always met, it was judged with confidence that the facility would protect radio equipment. It was noted that the ac power spark gap would remain shorted until ac power shut down, resulting in system upset.

  16. FAA Perspective

    NASA Technical Reports Server (NTRS)

    Bond, Tom

    2009-01-01

    This viewgraph presentation describes the Federal Aviation Administration's perspective on improvements on aircraft icing. The most important areas that are discussed include: 1) Improvements in SLD engineering tools to meet concerns about means of compliance (MOC); and 2) 3-D iced aerodynamics.

  17. The Role of the FAA in US Commercial Space Transportation

    NASA Astrophysics Data System (ADS)

    Smith, Patricia Grace

    2002-01-01

    The Commercial Space Launch Act of 1984 granted the United States (U.S.) Secretary of Transportation authority to regulate launch and launch site operations conducted by U.S. citizens or from the U.S. This authority is exercised only to the extent necessary to protect public health and safety, protect property, and preserve U.S. national security and foreign policy interests. The Secretary of Transportation has delegated this responsibility to the U.S. Federal Aviation Administration (FAA), and the FAA Associate Administrator for Commercial Space Transportation carries out activities associated with this responsibility. Since 1984, the Commercial Space Launch Act has been amended several times and the FAA's responsibilities regarding U.S. commercial space transportation activities have been expanded to include regulation of reentry activities and operation of reentry sites by U.S. citizens. Additionally, the FAA can determine safety approval criteria for vehicles, safety systems, processes, services and personnel. Since 1984, there have been no fatalities or injuries suffered by the public resulting from U.S. commercial space launch activities. While public safety is its primary focus, the FAA also promotes launches by U.S. commercial space transportation entities in order to support U.S. competitiveness in the global marketplace.

  18. 14 CFR 406.105 - Separation of functions for prosecuting civil penalties and advising the FAA decisionmaker.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; the Assistant Chief Counsel for Regulations; the Assistant Chief Counsel for Europe, Africa, and... the administrative law judge or by the FAA decisionmaker on appeal, except as counsel or a witness...

  19. 14 CFR 157.7 - FAA determinations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false FAA determinations. 157.7 Section 157.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS.... (a) The FAA will conduct an aeronautical study of an airport proposal and, after consultations...

  20. 14 CFR 145.223 - FAA inspections.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false FAA inspections. 145.223 Section 145.223 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.223 FAA inspections. (a)...

  1. The systems approach to airport security: The FAA (Federal Aviation Administration)/BWI (Baltimore-Washington International) Airport demonstration project

    SciTech Connect

    Caskey, D.L.; Olascoaga, M.T.

    1990-01-01

    Sandia National Laboratories has been involved in designing, installing and evaluating security systems for various applications during the past 15 years. A systems approach to security that evolved from this experience was applied to aviation security for the Federal Aviation Administration. A general systems study of aviation security in the United States was concluded in 1987. One result of the study was a recommendation that an enhanced security system concept designed to meet specified objectives be demonstrated at an operational airport. Baltimore-Washington International Airport was selected as the site for the demonstration project which began in 1988 and will be completed in 1992. This article introduced the systems approach to airport security and discussed its application at Baltimore-Washington International Airport. Examples of design features that could be included in an enhanced security concept also were presented, including details of the proposed Ramps Area Intrusion Detection System (RAIDS).

  2. FAA Training. Continued Improvements Needed in FAA's Controller Field Training Program. Report to Congressional Requesters.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Resources, Community, and Economic Development Div.

    Having examined the Federal Aviation Administration's (FAA) current program for providing field training to developmental and full-performance-level air traffic controllers, the General Accounting Office (GAO) recommends ensuring that FAA and contractor personnel are providing training consistently and uniformly. Further changes needed to ensure…

  3. Towards FAA Certification of UAVs

    NASA Technical Reports Server (NTRS)

    Nelson, Stacy

    2003-01-01

    As of June 30, 2003, all Unmanned Aerial Vehicles (UAV), no matter how small, must adhere to the same FAA regulations as human-piloted aircraft. These regulations include certification for flying in controlled airspace and certification of flight software based on RTCA DO-178B. This paper provides an overview of the steps necessary to obtain certification, as well as a discussion about the challenges UAV's face when trying to meet these requirements. It is divided into two parts: 1) Certifications for Flying in Controlled Airspace; 2) Certification of Flight Software per RTCA DO-178B.

  4. FAA Aviation Forecasts

    DTIC Science & Technology

    1992-02-01

    General Aviation .... ....... 110 General Economic Growth .......... .................. 110 Cost Factors ..................................... 110...General Aviation Aircraft Cost Indices ......... .. 261 -ii i Table of Contents (Continued) Page Appendix H: FAA Towered Airports...to GNP Growth (Constant Dollars) ..... 22 Commercial Air Carriers U.S. Air Carrier Revenue and Cost Trends .... ............... .28 Industry Operating

  5. 14 CFR 21.615 - FAA inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false FAA inspection. 21.615 Section 21.615 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT CERTIFICATION... quality control system; (c) Witness any tests; (d) Inspect the manufacturing facilities; and (e)...

  6. Future FAA Telecommunications Plan

    DTIC Science & Technology

    1991-08-01

    Equipment at the Position Each position will have identical ICSS modules. The quantities of modules available at each position will depend upon the...connectivity will be provided by FAA-owned cable at some locations and leased services (on-airport) at others, depending on local conditions. 16.6 DIVERSITY...others, depending on local conditions. Specific protocol, transmission, and hardware requirements will be provided in a future edition of this document

  7. 14 CFR 11.25 - How does FAA issue rules?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false How does FAA issue rules? 11.25 Section 11.25 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES GENERAL RULEMAKING PROCEDURES Rulemaking Procedures General § 11.25 How does FAA issue rules?...

  8. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  9. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  10. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  11. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  12. 14 CFR 49.11 - FAA Aircraft Registry.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false FAA Aircraft Registry. 49.11 Section 49.11 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT RECORDING OF AIRCRAFT TITLES AND SECURITY DOCUMENTS General § 49.11 FAA Aircraft Registry. To be eligible for...

  13. 14 CFR 47.19 - FAA Aircraft Registry.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false FAA Aircraft Registry. 47.19 Section 47.19 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRCRAFT REGISTRATION General § 47.19 FAA Aircraft Registry. Each application, request, notification, or...

  14. 49 CFR 1540.117 - Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 9 2012-10-01 2012-10-01 false Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or authorizations. 1540.117 Section 1540.117 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

  15. 49 CFR 1540.117 - Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 9 2014-10-01 2014-10-01 false Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or authorizations. 1540.117 Section 1540.117 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION...

  16. FAA Smoke Transport Code

    SciTech Connect

    Domino, Stefan; Luketa-Hanlin, Anay; Gallegos, Carlos

    2006-10-27

    FAA Smoke Transport Code, a physics-based Computational Fluid Dynamics tool, which couples heat, mass, and momentum transfer, has been developed to provide information on smoke transport in cargo compartments with various geometries and flight conditions. The software package contains a graphical user interface for specification of geometry and boundary conditions, analysis module for solving the governing equations, and a post-processing tool. The current code was produced by making substantial improvements and additions to a code obtained from a university. The original code was able to compute steady, uniform, isothermal turbulent pressurization. In addition, a preprocessor and postprocessor were added to arrive at the current software package.

  17. 7 CFR 51.1 - Administration of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Administration of regulations. 51.1 Section 51.1... MARKETING ACT OF 1946 FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND STANDARDS) Regulations 1 Administrative § 51.1 Administration of regulations. (a) The...

  18. 7 CFR 51.1 - Administration of regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 2 2012-01-01 2012-01-01 false Administration of regulations. 51.1 Section 51.1... MARKETING ACT OF 1946 FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND STANDARDS) Regulations 1 Administrative § 51.1 Administration of regulations. (a) The...

  19. 7 CFR 51.1 - Administration of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Administration of regulations. 51.1 Section 51.1... MARKETING ACT OF 1946 FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND STANDARDS) Regulations 1 Administrative § 51.1 Administration of regulations. (a) The...

  20. 14 CFR 39.5 - When does FAA issue airworthiness directives?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false When does FAA issue airworthiness directives? 39.5 Section 39.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS DIRECTIVES § 39.5 When does FAA issue airworthiness directives? FAA...

  1. A qualitative phenomenological study: Enhanced, risk-based FAA oversight on part 145 maintenance practices

    NASA Astrophysics Data System (ADS)

    Sheehan, Bryan G.

    The purpose of this qualitative phenomenological study was to examine the phenomenon of enhanced, risk-based Federal Aviation Administration (FAA) oversight of Part 145 repair stations that performed aircraft maintenance for Part 121 air carriers between 2007 and 2014 in Oklahoma. Specifically, this research was utilized to explore what operational changes have occurred in the domestic Part 145 repair station industry such as variations in management or hiring practices, training, recordkeeping and technical data, inventory and aircraft parts supply-chain logistics, equipment, and facilities. After interviewing 12 managers from Part 145 repair stations in Oklahoma, six major theme codes emerged from the data: quality of oversight before 2007, quality of oversight after 2007, advantages of oversight, disadvantages of oversight, status quo of oversight, and process improvement . Of those six major theme codes, 17 subthemes appeared from the data that were used to explain the phenomenon of enhanced oversight in the Part 145 repair station industry. Forty-two percent of the participants indicated a weak FAA oversight system that has hindered the continuous process improvement program in their repair stations. Some of them were financially burdened after hiring additional full-time quality assurance inspectors to specifically manage enhanced FAA oversight. Notwithstanding, the participants of the study indicated that the FAA must apply its surveillance on a more standardized and consistent basis. They want to see this standardization in how FAA inspectors interpret regulations and practice the same quality of oversight for all repair stations, particularly those that are repeat violators and fail to comply with federal aviation regulations. They believed that when the FAA enforces standardization on a consistent basis, repair stations can become more efficient and safer in the performance of their scope of work for the U.S. commercial air transportation industry.

  2. FAA navigation program

    NASA Technical Reports Server (NTRS)

    Blake, N. A.

    1978-01-01

    The FAA navigation program, which includes two major activity areas: those associated with certification of navigation systems to meet current requirements and those associated with building the data base needed to define future system improvements is examined. The near term activities, including the VORTAC upgrading program, the development of the technical data base needed for certification of LORAN C and OMEGA as a part of the current air navigation system, and the development of area navigation standards are examined in regard to cost factors and user requirements. Future system activities discussed include analysis of alternative system configurations made up of system elements including VORTAC VOR-DME, OMEGA and differential OMEGA, LORAN C, and GPS. The interrelationships between the near and far term programs are discussed. A helicopter IFR program which includes an assessment of the operational suitability of several navigation system alternatives for meeting helicopter navigation requirements for CONUS and offshore operations is reported.

  3. 7 CFR 52.1 - Administration of regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL... regulations. (a) The Administrator, Agricultural Marketing Service, United States Department of Agriculture...

  4. Data quality improvements for FAA

    SciTech Connect

    Perry, R.; Marlman, K.; Olson, D.; Werner, P.

    1997-09-01

    Effective communication among air safety professionals is only as good as the information being communicated. Data sharing cannot be effective unless the data are relevant to aviation safety problems, and decisions based on faulty data are likely to be invalid. The validity of aviation safety data depends on satisfying two primary characteristics. Data must accurately represent or conform to the real world (conformance), and it must be relevant or useful to addressing the problems at hand (utility). The FAA, in efforts to implement the Safety Performance Analysis System (SPAS), identified significant problems in the quality of the data which SPAS and FAA air safety professionals would use in defining the state of aviation safety in the US. These finding were reinforced by Department of Transportation Inspector General and General Accounting Office investigations into FAA surveillance of air transport operations. Many recent efforts to improve data quality have been centered on technological solutions to the problems. They concentrate on reducing errors in the data (conformance), but they cannot adequately address the relationship of data to need (utility). Sandia National Laboratories, working with the FAA`s Airport and Aircraft Safety Research and Development Division and the Flight Standards Service, has been involved in four programs to assist FAA in addressing their data quality problems. The Sandia approach has been data-driven rather than technology-driven. In other words, the focus has been on first establishing the data requirements by analyzing the FAA`s surveillance and decision-making processes. This process analysis looked at both the data requirements and the methods used to gather the data in order to address both the conformance and utility problems inherent in existing FAA data systems. This paper discusses Sandia`s data quality programs and their potential improvements to the safety analysis processes and surveillance programs of the FAA.

  5. 7 CFR 51.1 - Administration of regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Administration of regulations. 51.1 Section 51.1... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1 2 (INSPECTION, CERTIFICATION, AND STANDARDS) Regulations 1 Administrative § 51.1 Administration of...

  6. 7 CFR 51.1 - Administration of regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Administration of regulations. 51.1 Section 51.1... MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT FRESH FRUITS, VEGETABLES AND OTHER PRODUCTS 1,2 (INSPECTION, CERTIFICATION, AND STANDARDS) Regulations 1 Administrative § 51.1 Administration of...

  7. 15 CFR 30.16 - Export Administration Regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Export Administration Regulations. 30... OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS Export Control and Licensing Requirements § 30.16 Export Administration Regulations. The EAR issued by the U.S. Department of Commerce,...

  8. The FAA aging airplane program plan for transport aircraft

    NASA Technical Reports Server (NTRS)

    Curtis, Dayton; Lewis, Jess

    1992-01-01

    The Federal Aviation Administration (FAA) Aging Airplane Program is focused on five program areas: maintenance, transport airplanes, commuter airplanes, airplane engines, and research. These programs are complementary and concurrent, and have been in effect since 1988. The programs address the aging airplane challenge through different methods, including policies, procedures, and hardware development. Each program is carefully monitored and its progress tracked to ensure that the needs of the FAA, the industry, and the flying public are being met.

  9. NASA/FAA helicopter simulator workshop

    NASA Technical Reports Server (NTRS)

    Larsen, William E. (Editor); Randle, Robert J., Jr. (Editor); Bray, Richard S. (Editor); Zuk, John (Editor)

    1992-01-01

    A workshop was convened by the FAA and NASA for the purpose of providing a forum at which leading designers, manufacturers, and users of helicopter simulators could initiate and participate in a development process that would facilitate the formulation of qualification standards by the regulatory agency. Formal papers were presented, special topics were discussed in breakout sessions, and a draft FAA advisory circular defining specifications for helicopter simulators was presented and discussed. A working group of volunteers was formed to work with the National Simulator Program Office to develop a final version of the circular. The workshop attracted 90 individuals from a constituency of simulator manufacturers, training organizations, the military, civil regulators, research scientists, and five foreign countries.

  10. 75 FR 33682 - Export Administration Regulations; Technical Amendments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ... Bureau of Industry and Security 15 CFR Part 766 RIN 0694-AE93 Export Administration Regulations... amendment to the Export Administration Regulations (EAR). Specifically, BIS deletes references concerning Federal court jurisdiction for judicial review of final decisions and orders issued in BIS export...

  11. FAA Film Catalog.

    ERIC Educational Resources Information Center

    Federal Aviation Administration (DOT), Washington, DC.

    Some 75 films from the U.S. Department of Transportation's Federal Aviation Administration are listed in this catalog. Topics dealt with include aerodynamics, airports, aviation history and careers, flying clubs, navigation and weather. Most of the films are 16mm sound and color productions. Filmstrips requiring a 35mm projector and phonograph or…

  12. 77 FR 40493 - Export Administration Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... Bureau of Industry and Security 15 CFR Parts 740, 742, 748, 750, 752, and 760 Export Administration... heading of paragraph (d) to read ``Shippers Export Declaration or Automated Export System Record''. 0 2...): Once a mass market classification request is accepted in SNAP-R, you may export and reexport...

  13. 15 CFR 30.16 - Export Administration Regulations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Export Administration Regulations. 30.16 Section 30.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS Export Control and...

  14. 15 CFR 30.16 - Export Administration Regulations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Export Administration Regulations. 30.16 Section 30.16 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE FOREIGN TRADE REGULATIONS Export Control and...

  15. 14 CFR 193.7 - What does it mean for the FAA to designate information as protected?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... information as protected? 193.7 Section 193.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION... INFORMATION § 193.7 What does it mean for the FAA to designate information as protected? (a) General. When the FAA issues an order designating information as protected under this part, the FAA does not...

  16. FAA Vertical Flight Bibliography, 1962 - 1994

    DTIC Science & Technology

    1994-08-01

    Angeles Area (Bernhart V. Dinerman) (NTIS: AD-735399) FAA-RD-71-105 Heliport Beacon Design, Construction, and Testing ( Fred Walter) (NTIS: AD-745514...Shollenberger) (NTIS: AD-A214085) FAA-RD-71-105 Heliport Beacon Design, Construction, and Testing ( Fred Walter) (NTIS: AD-745514) FAA/CT-TN86/64 Heliport...of Technology) FAA-AEE-92-03 FISHER, F.A. (Lightning Technologies Inc.) FAA/CT-89/22 PIXLER, RICHARD S. ( Hoyle Tanner and Associates) FAA/RD-93/2

  17. 78 FR 63276 - Interim Policy, FAA Review of Solar Energy System Projects on Federally Obligated Airports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... Federal Aviation Administration Interim Policy, FAA Review of Solar Energy System Projects on Federally... federally obligated airports to construct solar energy systems on airport property. FAA is adopting an... for measuring ocular impact of proposed solar energy systems which are effective upon publication....

  18. 14 CFR 11.31 - How does FAA process direct final rules?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false How does FAA process direct final rules? 11.31 Section 11.31 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES GENERAL RULEMAKING PROCEDURES Rulemaking Procedures General § 11.31 How does FAA...

  19. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false FAA/USSPACECOM Launch Notification Form A... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part 415—FAA/USSPACECOM Launch Notification Form ER21AP99.001 ER21AP99.002...

  20. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false FAA/USSPACECOM Launch Notification Form A... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part 415—FAA/USSPACECOM Launch Notification Form ER21AP99.001 ER21AP99.002...

  1. 75 FR 6433 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-09

    ... Federal Aviation Administration Notice of Availability of a Draft Environmental Assessment and Public...: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Availability of a Draft Environmental... Chicago, Illinois. SUMMARY: The Federal Aviation Administration (FAA) proposes to fund, construct,...

  2. Food and Drug Administration regulation and evaluation of vaccines.

    PubMed

    Marshall, Valerie; Baylor, Norman W

    2011-05-01

    The vaccine-approval process in the United States is regulated by the Center for Biologics Evaluation and Research of the US Food and Drug Administration. Throughout the life cycle of development, from preclinical studies to after licensure, vaccines are subject to rigorous testing and oversight. Manufacturers must adhere to good manufacturing practices and control procedures to ensure the quality of vaccines. As mandated by Title 21 of the Code of Regulations, licensed vaccines must meet stringent criteria for safety, efficacy, and potency.

  3. 15 CFR 30.16 - Export Administration Regulations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Requirements § 30.16 Export Administration Regulations. The EAR issued by the U.S. Department of Commerce, BIS, also contain some additional reporting requirements pertaining to EEI (see 15 CFR 730-774). (a) The EAR... export control information in the EEI are found in the EAR....

  4. 15 CFR 30.16 - Export Administration Regulations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Requirements § 30.16 Export Administration Regulations. The EAR issued by the U.S. Department of Commerce, BIS, also contain some additional reporting requirements pertaining to EEI (see 15 CFR 730-774). (a) The EAR... export control information in the EEI are found in the EAR....

  5. 75 FR 33989 - Export Administration Regulations: Technical Corrections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... Security 15 CFR Part 774 RIN 0694-AE69 Export Administration Regulations: Technical Corrections AGENCY... License Requirements section of Export Control Classification Number 2B001 and the other is in the..., clarified language regarding certain performance criteria of turning machines covered by Export...

  6. 75 FR 31678 - Export Administration Regulations: Technical Corrections

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-04

    ... Bureau of Industry and Security 15 CFR Parts 734, 740, 744, 748, 750, 766 and 774 RIN 0694-AE69 Export...: Final Rule. SUMMARY: This rule clarifies language concerning the de minimis provisions of the Export... Foreign Made Items The Export Administration Regulations (EAR) generally do not apply to items that...

  7. NDE research efforts at the FAA Center for Aviation Systems Reliability

    NASA Technical Reports Server (NTRS)

    Thompson, Donald O.; Brasche, Lisa J. H.

    1992-01-01

    The Federal Aviation Administration-Center for Aviation Systems Reliability (FAA-CASR), a part of the Institute for Physical Research and Technology at Iowa State University, began operation in the Fall of 1990 with funding from the FAA. The mission of the FAA-CASR is to develop quantitative nondestructive evaluation (NDE) methods for aircraft structures and materials including prototype instrumentation, software, techniques, and procedures and to develop and maintain comprehensive education and training programs in aviation specific inspection procedures and practices. To accomplish this mission, FAA-CASR brings together resources from universities, government, and industry to develop a comprehensive approach to problems specific to the aviation industry. The problem areas are targeted by the FAA, aviation manufacturers, the airline industry and other members of the aviation business community. This consortium approach ensures that the focus of the efforts is on relevant problems and also facilitates effective transfer of the results to industry.

  8. 75 FR 14448 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practices; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public workshop. SUMMARY: The Food and Drug Administration (FDA) Los...

  9. 75 FR 13763 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1217...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... ADMINISTRATION DEPARTMENT OF DEFENSE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1217, Lessor's Annual Cost Statement AGENCY: Department of Defense (DOD), General Services Administration (GSA), and National Aeronautics...

  10. 14 CFR 406.105 - Separation of functions for prosecuting civil penalties and advising the FAA decisionmaker.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Separation of functions for...

  11. 14 CFR 406.105 - Separation of functions for prosecuting civil penalties and advising the FAA decisionmaker.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Separation of functions for...

  12. 14 CFR 406.105 - Separation of functions for prosecuting civil penalties and advising the FAA decisionmaker.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Separation of functions for...

  13. 14 CFR 406.105 - Separation of functions for prosecuting civil penalties and advising the FAA decisionmaker.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Separation of functions for...

  14. 75 FR 59102 - Defense Federal Acquisition Regulation Supplement; Part 204, Administrative Matters

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ...; Part 204, Administrative Matters AGENCY: Defense Acquisition Regulations System, Department of Defense.... 0 Therefore 48 CFR part 204 is amended as follows: PART 204--ADMINISTRATIVE MATTERS 0 1....

  15. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware...

  16. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware...

  17. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware...

  18. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware...

  19. 18 CFR 410.1 - Basin regulations-Water Code and Administrative Manual-Part III Water Quality Regulations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Code and Administrative Manual-Part III Water Quality Regulations. 410.1 Section 410.1 Conservation of... CODE AND ADMINISTRATIVE MANUAL-PART III WATER QUALITY REGULATIONS § 410.1 Basin regulations—Water Code and Administrative Manual—Part III Water Quality Regulations. (a) The Water Code of the Delaware...

  20. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Weapons Convention Regulations and the Export Administration Regulations, the International Traffic in... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL INFORMATION AND OVERVIEW OF THE CHEMICAL WEAPONS CONVENTION REGULATIONS (CWCR) § 710.6 Relationship between...

  1. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Weapons Convention Regulations and the Export Administration Regulations, the International Traffic in... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL INFORMATION AND OVERVIEW OF THE CHEMICAL WEAPONS CONVENTION REGULATIONS (CWCR) § 710.6 Relationship between...

  2. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Weapons Convention Regulations and the Export Administration Regulations, the International Traffic in... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL INFORMATION AND OVERVIEW OF THE CHEMICAL WEAPONS CONVENTION REGULATIONS (CWCR) § 710.6 Relationship between...

  3. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Weapons Convention Regulations and the Export Administration Regulations, the International Traffic in... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL INFORMATION AND OVERVIEW OF THE CHEMICAL WEAPONS CONVENTION REGULATIONS (CWCR) § 710.6 Relationship between...

  4. 15 CFR 710.6 - Relationship between the Chemical Weapons Convention Regulations and the Export Administration...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Weapons Convention Regulations and the Export Administration Regulations, the International Traffic in... INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS GENERAL INFORMATION AND OVERVIEW OF THE CHEMICAL WEAPONS CONVENTION REGULATIONS (CWCR) § 710.6 Relationship between...

  5. 77 FR 66466 - General Services Administration Regulation; Information Collection; Packing List Clause

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-05

    ... ADMINISTRATION General Services Administration Regulation; Information Collection; Packing List Clause AGENCY... packing list clause. Public comments are particularly invited on: Whether this collection of information..., Packing List Clause, by any of the following methods: Regulations.gov :...

  6. FAA Air Traffic Activity. Fiscal Year 1991

    DTIC Science & Technology

    1991-01-01

    74 0 0 74 0 UHUE ............................................................................. HI M ZHN 1683 1395 62 41 185 LIMA ALLEN COUNTY...1560433 TABLE 24- FISCAL YEAR 1991 FAA CONTRACTOR-OPERATED TRAFIC CONTROL TOWERS BY RANK ORDER OF

  7. 41 CFR 105-1.101 - General Services Administration Property Management Regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administration Property Management Regulations. 105-1.101 Section 105-1.101 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.101 General Services Administration Property Management...

  8. 21 CFR 10.90 - Food and Drug Administration regulations, recommendations, and agreements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Food and Drug Administration regulations, recommendations, and agreements. 10.90 Section 10.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Procedures § 10.90 Food and Drug Administration regulations, recommendations, and agreements. (a)...

  9. 21 CFR 10.90 - Food and Drug Administration regulations, recommendations, and agreements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Food and Drug Administration regulations, recommendations, and agreements. 10.90 Section 10.90 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF... Procedures § 10.90 Food and Drug Administration regulations, recommendations, and agreements. (a)...

  10. The FAA satellite communications program

    NASA Technical Reports Server (NTRS)

    Burcham, Karen L.

    1993-01-01

    The Federal Aviation Administration is developing satellite communications capabilities to enhance air traffic services, first in oceanic and remote regions, and later for United States domestic services. The program includes four projects which develop technical standards, assure adequate system performance, support implementation, and provide for research and development for selected areas of U.S. domestic satellite communications. The continuing focus is the application of automated data communications, which is already permitting enhanced and regular position reporting. Voice developments, necessary for non-routine communications, are also included among the necessary activities to improve ATC communications.

  11. 75 FR 73951 - Amendments to General Regulations of the Food and Drug Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Parts 1, 14, and 17 RIN 0910-AG55 Amendments to General Regulations of the Food and Drug Administration AGENCY: Food and Drug Administration, HHS. ACTION: Direct final rule. SUMMARY: The Food and Drug Administration (FDA) is amending certain of its...

  12. 75 FR 73984 - Amendments to General Regulations of the Food and Drug Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Parts 1, 14, and 17 RIN 0910-AG55 Amendments to General Regulations of the Food and Drug Administration AGENCY: Food and Drug Administration, HHS. ACTION: Proposed rule. SUMMARY: The Food and Drug Administration (FDA) is proposing to amend certain of its...

  13. FAA/NASA Joint University Program for Air Transportation Research 1994-1995

    NASA Technical Reports Server (NTRS)

    Remer, J. H.

    1998-01-01

    The Joint University Program for Air Transportation Research (JUP) is a coordinated set of three grants co-sponsored by the Federal Aviation Administration (FAA) and the National Aeronautics and Space Administration (NASA). Under JUP, three institutions: the Massachusetts Institute of Technology, Princeton, and Ohio Universities receive research grants and collaborate with FAA and NASA in defining and performing civil aeronautics research in a multitude of areas. Some of these disciplines are artificial intelligence, control theory, atmospheric hazards, navigation, avionics, human factors, flight dynamics, air traffic management, and electronic communications.

  14. 75 FR 1788 - General Services Administration Regulation; Submission for OMB Review; Packing List Clause

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... ADMINISTRATION General Services Administration Regulation; Submission for OMB Review; Packing List Clause AGENCY... approved information collection requirement regarding the packing list clause. A request for public..., Packing List Clause, in all correspondence. FOR FURTHER INFORMATION CONTACT: Michael O....

  15. 77 FR 69441 - Federal Acquisition Regulation; Information Collection; Cost Accounting Standards Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... Regulation; Information Collection; Cost Accounting Standards Administration AGENCY: Department of Defense...: Under the provisions of the Paperwork Reduction Act, the Regulatory Secretariat will be submitting to... approved information collection requirement concerning cost accounting standards administration....

  16. FAA Air Traffic Activity: Fiscal Year 1989

    DTIC Science & Technology

    1990-11-01

    H I M ZH N 178b 1487 49 52 200 LIMA ALLEN COUNTY ...................... ................. OH N ZID 610 0 12 589 9 LIN C H FIE LD...1937 GRAND TOTAL ................................................. 1229508 174 TABLE 24 - FISCAL YEAR 1989 FAA CONTRACTOR-OPERATED TRAFIC CONTROL

  17. FAA Air Traffic Activity: FY 1990. Addendum.

    DTIC Science & Technology

    1990-01-01

    HI M ZHN 1896 1578 59 55 204 LIMA ALLEN COUNTY.................................... OH N ZID 607 0 22 576 9 LINCOLN LOGAN COUNTY...GA N 24 2011 GRAND TOTAL ...................................... .... 1494614 TABLE 24- FISCAL YEAR 1990 FAA CONTRACTOR-OPERATED TRAFIC CONTROL

  18. 77 FR 14016 - General Services Administration Acquisition Regulation; Preparation, Submission, and Negotiation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ...] General Services Administration Acquisition Regulation; Preparation, Submission, and Negotiation of... Negotiation of Subcontracting Plans; Correction. Correction In the information collection document...

  19. 7 CFR 1260.520 - Responsibility for administration of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research: Certification and Nomination Procedures for the Cattlemen's Beef Promotion and Research Board § 1260.520 Responsibility for administration...

  20. 77 FR 74631 - General Services Administration Acquisition Regulation: Modifications (Multiple Award Schedules...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-17

    ... collection requirement regarding General Services Administration Acquisition Regulation (GSAR) clause... Acquisition Regulation (GSAR) to add clause 552.243-72; Modifications (Multiple Award Schedules). Under the modifications clause, vendors may request a contract modification by submitting a request to the...

  1. 7 CFR 52.1 - Administration of regulations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE REGULATIONS AND STANDARDS UNDER THE AGRICULTURAL MARKETING ACT OF 1946 PROCESSED FRUITS AND VEGETABLES, PROCESSED PRODUCTS THEREOF, AND CERTAIN...

  2. Index to FAA Office of Aerospace Medicine Reports: 1961 Through 2012

    DTIC Science & Technology

    2013-01-01

    Aerospace Medical Institute Federal Aviation Administration Oklahoma City, OK 73125 January 2013 Final Report DOT/FAA/AM-13/1 Office of Aerospace Medicine...Blvd. P.O. Box 25082 Norman, OK 73071 Oklahoma City, OK 73125 11. Contract or Grant No. 12. Sponsoring Agency Name and Address 13. Type of... Oklahoma City, Oklahoma , was attended by (left-right) then-Acting Administrator Michael Huerta, Associate Administrator for Aviation Safety Peggy

  3. 77 FR 22191 - Revisions to the Export Administration Regulations (EAR): Export Control Classification Number...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... the Export Administration Regulations (EAR): Export Control Classification Number 0Y521 Series, Items..., which amends the Export Administration Regulations (EAR) by establishing a new Export Control... the EAR. The ECCN 0Y521 series will be used for items that warrant control on the CCL but are not...

  4. 14 CFR 11.38 - What public comment procedures does the FAA follow for Special Conditions?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false What public comment procedures does the FAA follow for Special Conditions? 11.38 Section 11.38 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES GENERAL RULEMAKING PROCEDURES Rulemaking Procedures...

  5. 14 CFR 11.33 - How can I track FAA's rulemaking activities?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false How can I track FAA's rulemaking activities? 11.33 Section 11.33 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES GENERAL RULEMAKING PROCEDURES Rulemaking Procedures General § 11.33 How can...

  6. 14 CFR 11.73 - How does FAA process petitions for rulemaking?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false How does FAA process petitions for rulemaking? 11.73 Section 11.73 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... action. (d) If we have tasked ARAC to study the general subject area of your petition, we will ask...

  7. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. A notification to the Federal...

  8. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. A notification to the Federal...

  9. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. Link to an amendment published at 79 FR 56986,...

  10. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. A notification to the Federal...

  11. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. A notification to the...

  12. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. A notification to the...

  13. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. A notification to the...

  14. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. Link to an amendment...

  15. 47 CFR 17.7 - Antenna structures requiring notification to the FAA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Antenna structures requiring notification to..., MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.7 Antenna structures requiring notification to the FAA. A notification to the Federal...

  16. 47 CFR 17.14 - Certain antenna structures exempt from notification to the FAA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Certain antenna structures exempt from... CONSTRUCTION, MARKING, AND LIGHTING OF ANTENNA STRUCTURES Federal Aviation Administration Notification Criteria § 17.14 Certain antenna structures exempt from notification to the FAA. A notification to the...

  17. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false FAA/USSPACECOM Launch Notification Form A Appendix A to Part 415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part...

  18. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false FAA/USSPACECOM Launch Notification Form A Appendix A to Part 415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part...

  19. 14 CFR Appendix A to Part 415 - FAA/USSPACECOM Launch Notification Form

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false FAA/USSPACECOM Launch Notification Form A Appendix A to Part 415 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH LICENSE Pt. 415, App. A Appendix A to Part...

  20. 14 CFR 39.5 - When does FAA issue airworthiness directives?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false When does FAA issue airworthiness directives? 39.5 Section 39.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... an airworthiness directive addressing a product when we find that: (a) An unsafe condition exists...

  1. 14 CFR 39.5 - When does FAA issue airworthiness directives?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false When does FAA issue airworthiness directives? 39.5 Section 39.5 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... an airworthiness directive addressing a product when we find that: (a) An unsafe condition exists...

  2. FAA Air Traffic Activity, Fiscal Year 1980,

    DTIC Science & Technology

    2014-09-26

    instrument flight rules ( IFR ) at ARTC centers by aviation category, center, and region. Chapter II includes summaries of aircraft operations at FAA...and secondary airports. Data for FSSs, CS/Ts, and IFSSs appear in Chapter V. This information includes total flight services, IFR -DVFR and VFR aircraft...contacted, IFR -DVFR and VFR flight plans originated, pilot briefs and airport advisories by facility, state, and region. Rank order tables are

  3. FAA evaluation of UV technology for runway incursion prevention and low-visibility landings

    NASA Astrophysics Data System (ADS)

    Norris, Victor J., Jr.

    2003-09-01

    The Federal Aviation Administration (FAA) is currently evaluating a solar blind ultraviolet (UV) technology, called FogEye, that is being developed by Norris Electro Optical Systems. The technology allows for transmission and reception of low level UV signals that are free of any natural background noise. It also offers favorable atmospheric transmission characteristics. Conclusions of the FAA evaluation thus far are that the technology has considerable merit, and that applications such as preventing runway incursions and use as an Integrity Monitor during low visibility landings should be operationally assessed.

  4. Technology Development, Validation, and Transfer Via the FAA Airworthiness Assurance Validation

    SciTech Connect

    Perry, R.L.

    1999-04-15

    In 1991, the Federal Aviation Administration (FAA) established an Airworthiness Assurance NDI Validation Center (AANC) at Sandia National Laboratories. Its primary mission is to support technology development, validation, and transfer to industry in order to enhance the airworthiness and improve the aircraft maintenance practices of the U.S. commercial aviation industry. The Center conducts projects in a myriad of engineering disciplines. The results are placed in the public domain so that the industry at-large can reap the benefits of FAA-funded Research and Development efforts. To support the Center's goals, the FAA/AANC has set up a hangar facility at the Albuquerque International Airport which contains a collection of transport and commuter aircraft as well as other test specimens. The facility replicates a working maintenance environment by incorporating both the physical inspection difficulties as well as the environmental factors which influence maintenance reliability.

  5. Discovering the Regulatory Considerations of the Federal Aviation Administration: Interviewing the Aviation Rulemaking Advisory Committee

    NASA Technical Reports Server (NTRS)

    Lu, Chien-tsung

    2005-01-01

    Maintenance Resource Management (MRM) training for aviation mechanics has become mandatory in many industrialized countries since 1998. Yet, to date, MRM training remains optional in the U.S. Interestingly, a similar safety discipline, namely Crew/Cockpit Resource Management (CRM), is mandatory for pilots, flight engineers, flight attendants, and dispatchers and is regulated in the Federal Aviation Administration s (FAA) Federal Aviation Regulations (FARs). If MRM training is important to enhance aviation technicians working behavior, the rationale to not regulate it opens a window for study. This research aims to inductively investigate the FAA s regulatory rationale concerning MRM training based on direct inputs from the FAA s Aviation Rulemaking Advisory Committee (ARAC) members. Delphi methodology associated with purposive sampling technique was adopted. The result revealed that the FAA cannot regulate MRM because the aviation industry is strongly opposed to it due to the lack of training budgets, the need of a quantifiable cost-effect analysis, concern over the FAA s inspection workforce, an ongoing voluntary alternative called the Air Transportation Surveillance System (ATOS), the government s lower priority on maintenance after 9/11, and the airlines tight embracement of operational flexibility without regulation.

  6. Environmental Compliance Assessment Protocol - Federal Aviation Administration (ECAP - FAA)

    DTIC Science & Technology

    1993-10-01

    dlithiolan,2-y Carbamic chlotdds, 1 K U097 79-44-7 dimethyl- Carbaryl 100 K 63-25-2 Carbofuran 10/10000o 10 1563-66-2 Carbon disuiffide 10,000 100 K...chloro- 1000 1000 P027 542-76-7 Propoxur x 114-26-1 Propyl chioroloumae 500 109-61-5 Propylene (Propene) x 116-07-1 Propylene oxide 10,000 100 1 75-56

  7. FAA (Federal Aviation Administration) Air Traffic Activity FY 1983.

    DTIC Science & Technology

    1983-09-30

    tI1148335 NEVA (A LAS VERAS FCCARRAN INTL ( LAT ) L PRIMARY OPERAT1ENS 2E3549 121tE* 5P ? c /619 1 4අ SECEUARY OPERATIONS 13P8 3( 113* 1 1I OVERFLIGHTS 8026A...34NLSCATINE IA N I 1L1 27E 14 204 0PILSCLE SHOALS AL S 1 HSV 1366 55p 26 769 15 MNSKEGCN MI N I MKG 2263 547 e34 911 111PlSKCGEE OK h ZF 17 ) 3 Ii...821756 2K10M EI-CUiK :KV PARK NY N4 ,NY 1i 0 1 8* R(OPUC OH N 7ZSf 4t. 16 1 26 ZAIONE 41. S 1 HSV 23! C VI i~e11 tbU1JC CALLS MN IK ZAP4 ’I-36i1 .(EC CITY

  8. FAA (Federal Aviation Administration) Air Traffic Activity FY 1982,

    DTIC Science & Technology

    1982-09-30

    52442 12228 1282 36579 2351 LOCAL OPERATIONS 2070C 16669 4211 TOTAL OPERATIONS 73142 12228 1262 53248 6i FARGO HECTOR FIELD (FAR) S I TINERANT OPERATIONS...252 4991 OSIOSH liIN4e FIELD 01 N 173 7291K FORGO HECTOR FIELD NO S as3 09911 ROANOKE VA 1 174 100 FLXNT RI SHOP "I S Z A 49F|r PALM SPRI&NS...INTERNATIONAL AK M 38 6744 CHARLESTON mV 5 110 1093 SAN DIEGO LINOENG CA II 39 63626 LANSING MI 5 119 los @ PORTLAND INTERNATIONAL OR N 40 629)4 FARGO HECTOR

  9. FAA (Federal Aviation Administration) Air Traffic Activity FY 1985.

    DTIC Science & Technology

    1985-09-30

    SHERNA14 OK N 395 4247 FORT MYERS REGI1NAL FL S 396 3035 PRESCOTT 2 AZ N 397 2899 KWAJALEIN AAF K N 316 PAGa PAGO IFSS AS N 399 186 GRAND TOTAL 22373031...CA N 340 10568 PRESCOTT 2 AZ N 417 KINST3N NL N 341 10349 GRAND TOTAL 38702396 POULHKEEPSIE DUCHESS CO NY N 342 10311 KLANATH FALLS ON N 343 10300...9 MINNEAPOLIS FLYING CLOUD HN L I 4SP 1372 0 4 1366 2 MINNEAPOLIS JAMES FIELL MN L I NSP 67 0 7 58 2 MINNEAPOLIS ST PAUL INTL fn L 1 4SP 29018 21180

  10. FAA (Federal Aviation Administration) Air Traffic Activity: Fiscal Year 1987

    DTIC Science & Technology

    1987-09-30

    ITNI N ITINERANT OPERATIJNIS 52463 4333 9922 3 7540 418 LOCAL OPERArIgNS 46988 %3902 56 TOTAL OPERATIONS 99451 4513 9922 84442 iD4 JOHN F KENNEIT INTL...ITINERANT OPERATIDIS ’.33?0 3 4599 9776.4 351 LOCAL OPERATIONS 38134 3&6 1945 TOTAL OPERATIONS 8145’. 3 4S99 74053 2902 L - LUBBOCK LB S IrIVEvANT...DC L 29 324365 WORTI PHILADELPHIA PA L 1og 181150 JOHN F 951MSDI INTL Ny L 30 311521 MILLSBORO OR N 11 185933 FORT tIRYN MERCHAN TI L 31 304342 EL

  11. 22 CFR 120.42 - Subject to the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Regulations (EAR). 120.42 Section 120.42 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.42 Subject to the Export Administration Regulations (EAR). Items “subject to the EAR” are those items listed on the Commerce Control List in part 774 of the EAR and...

  12. A perspective on the FAA approval process: Integrating rotorcraft displays, controls and workload

    NASA Technical Reports Server (NTRS)

    Green, David L.; Hart, Jake; Hwoschinsky, Peter

    1993-01-01

    The FAA is responsible for making the determination that a helicopter is safe for IFR operations in the National Airspace System (NAS). This involves objective and subjective evaluations of cockpit displays, flying qualities, procedures and human factors as they affect performance and workload. After all of the objective evaluations are completed, and all Federal Regulations have been met, FAA pilots make the final subjective judgement as to suitability for use by civil pilots in the NAS. The paper uses the flying qualities and pilot workload characteristics of a small helicopter to help examine the FAA pilot's involvement in this process. The result highlights the strengths of the process and its importance to the approval of new aircraft and equipments for civil IFR helicopter applications. The paper also identifies opportunities for improvement.

  13. Human Temperature Regulation during Exercise after Oral Pyridostigmine Administration

    DTIC Science & Technology

    1990-03-01

    or vasomotor elements) which may or during exercise . Tsk was different in the three conditions by result from increased cholinergic activity after...of cholines- oration during steady-state exercise in control experi- terase enzyme activity units by the manual delta pH method ments. Thus, the small...Reprint & Copyright © by Aerospace Medical Association, Washington. DC D T IC ELECTF 0 Human Temperature Regulation * ~During Exercise After N Oral

  14. 78 FR 18285 - General Services Administration Acquisition Regulation; Submission for OMB Review; Modifications...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... OMB Review; Modifications 552.243-72 (Multiple Award Schedules) AGENCY: Office of Acquisition Policy... to review and approve an information collection requirement regarding the Modifications (Multiple... Services Administration Acquisition Regulation (GSAR) to add clause 552.243-72 Modifications...

  15. 77 FR 11355 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-24

    ... imminent cost savings that will result. Contractor business systems and internal controls are the first... Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS... contractor business systems. DATES: Effective date: February 24, 2012. FOR FURTHER INFORMATION CONTACT:...

  16. 77 FR 31026 - Requirements for Importing Food and Drug Administration Regulated Products Into the United States

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... respect to importing pharmaceutical products, medical devices, food products, as well as technology which... No: 2012-12592] DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-N-0001] Requirements for Importing Food and Drug Administration Regulated Products Into the...

  17. 78 FR 11188 - General Services Administration Regulation; Submission for OMB Review; Packing List Clause

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... ADMINISTRATION General Services Administration Regulation; Submission for OMB Review; Packing List Clause AGENCY... packing list clause. A notice was published in the Federal Register at 77 FR 66466, on November 5, 2012...: Submit comments identified by Information Collection 3090- 0246, Packing List Clause, by any of...

  18. 21 CFR 10.90 - Food and Drug Administration regulations, recommendations, and agreements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATIVE PRACTICES AND PROCEDURES General Administrative.... FDA regulations are issued in the Federal Register under § 10.40 or § 10.50 and codified in the Code... included in a separate public file of recommendations established by the Division of Dockets Management...

  19. 75 FR 82029 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1217...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... Doc No: 2010-32775] GENERAL SERVICES ADMINISTRATION [OMB Control No. 3090-00XX; Docket 2010-0002; Sequence 15] General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Form 1217, Lessor's Annual Cost Statement AGENCY: Department of Defense (DOD), General...

  20. 75 FR 2457 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ... Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS Case... the definition and administration of contractor business systems as follows: 1. DoD is proposing to... analysis is summarized as follows: The objective of the rule is to establish a definition for...

  1. 78 FR 60695 - Regulatory Reorganization; Administrative Changes to Regulations Due to the Consolidation of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Reorganization; Administrative Changes to Regulations Due to the Consolidation of the Financial Management... consolidated the bureaus formerly known as the Financial Management Service (``FMS'') and the Bureau of the... consolidation requires reorganization of, and administrative changes to, title 31 of the Code of...

  2. The Infralimbic Cortex Regulates the Consolidation of Extinction after Cocaine Self-Administration

    ERIC Educational Resources Information Center

    LaLumiere, Ryan T.; Niehoff, Kate E.; Kalivas, Peter W.

    2010-01-01

    The infralimbic cortex (IL) regulates the consolidation of extinction learning for fear conditioning. Whether the IL influences the consolidation of extinction learning for cocaine self-administration is unknown. To address this issue, male Sprague-Dawley rats underwent 2 wk of cocaine self-administration followed by extinction training. On the…

  3. 75 FR 13131 - General Services Administration Acquisition Regulation; Submission for OMB Review; GSA Advantage...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-18

    ...) contractors must participate in the GSA Advantage! system at 552.238-55. It is an online shopping service... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION General Services Administration Acquisition Regulation; Submission for OMB Review; GSA...

  4. 76 FR 78966 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... Federal Aviation Administration Approval of Noise Compatibility Program for Kona International Airport at Keahole, Keahole, North Kona, HI AGENCY: Federal Aviation Administration, DOT. ACTION: Notice. SUMMARY: The Federal Aviation Administration (FAA) announces its findings on the noise compatibility...

  5. 78 FR 13395 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ... Federal Aviation Administration Notice of Availability of Draft Alaska National Interest Lands Conservation Act (ANILCA) Section 810 Subsistence Evaluation. AGENCY: Federal Aviation Administration (FAA... Aviation Administration, Airports Division, 222 West 7th Avenue, Box 14, Anchorage, AK 99513. 5....

  6. Implementation of the FAA research and development electromagnetic database

    NASA Technical Reports Server (NTRS)

    Mcdowall, R. L.; Grush, D. J.; Cook, D. M.; Glynn, M. S.

    1991-01-01

    The Idaho National Engineering Laboratory (INEL) has been assisting the FAA in developing a database of information about lightning. The FAA Research and Development Electromagnetic Database (FRED) will ultimately contain data from a variety of airborne and ground-based lightning research projects. An outline of the data currently available in FRED is presented. The data sources which the FAA intends to incorporate into FRED are listed. In addition, it describes how the researchers may access and use the FRED menu system.

  7. 77 FR 15370 - General Services Administration Acquisition Regulation; Information Collection; Price Reductions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-15

    ... Clause; Extension of Comment Period AGENCY: Office of Acquisition Policy; General Services Administration... date of the notice of request for comments regarding OMB Control No. 3090-0235, Price Reductions Clause... Reductions Clause, by any of the following methods: Regulations.gov : http://www.regulations.gov ....

  8. 78 FR 76738 - Updated Statements of Legal Authority for the Export Administration Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...This rule updates the Code of Federal Regulations (CFR) legal authority paragraphs in the Export Administration Regulations (EAR) to include the citations to five Presidential notices extending emergencies declared pursuant to the International Emergency Economic Powers Act. This is a procedural rule that only updates authority paragraphs of the EAR. It does not alter any right, obligation or......

  9. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  10. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  11. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  12. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  13. 14 CFR 294.33 - Compliance with the regulations of the Federal Aviation Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Federal Aviation Administration. 294.33 Section 294.33 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION (AVIATION PROCEEDINGS) ECONOMIC REGULATIONS CANADIAN CHARTER AIR TAXI OPERATORS General Rules for Registrants § 294.33 Compliance with the regulations of the Federal...

  14. 76 FR 12563 - Amendments to General Regulations of the Food and Drug Administration; Confirmation of Effective...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Parts 1, 14, and 17 RIN 0910-AG55 Amendments to... certain general regulations of FDA to include tobacco products, where appropriate, in light of FDA's authority to regulate these products under the Family Smoking Prevention and Tobacco Control Act,...

  15. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF THE... DISCLOSURE § 250.7 Pertinent portions of Export Administration Regulations (EAR). The following pertinent section of the EAR is provided for the guidance of DoD personnel in determining the...

  16. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF THE... DISCLOSURE § 250.7 Pertinent portions of Export Administration Regulations (EAR). The following pertinent section of the EAR is provided for the guidance of DoD personnel in determining the...

  17. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF THE... DISCLOSURE § 250.7 Pertinent portions of Export Administration Regulations (EAR). The following pertinent section of the EAR is provided for the guidance of DoD personnel in determining the...

  18. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF THE... DISCLOSURE § 250.7 Pertinent portions of Export Administration Regulations (EAR). The following pertinent section of the EAR is provided for the guidance of DoD personnel in determining the...

  19. 32 CFR 250.7 - Pertinent portions of Export Administration Regulations (EAR).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations (EAR). 250.7 Section 250.7 National Defense Department of Defense (Continued) OFFICE OF THE... DISCLOSURE § 250.7 Pertinent portions of Export Administration Regulations (EAR). The following pertinent section of the EAR is provided for the guidance of DoD personnel in determining the...

  20. 75 FR 3236 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... and the provision at 52.230-5 include pertinent rules and regulations related to the Cost Accounting... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCIES: Department of...-0129). SUMMARY: Under the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35),...

  1. 75 FR 76692 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-09

    ... Defense Acquisition Regulations System 48 CFR Parts 215, 234, 242, 244, 245, and 252 RIN 0750-AG58 Defense Federal Acquisition Regulation Supplement; Business Systems--Definition and Administration (DFARS Case... INFORMATION: I. Background DoD published a proposed rule for Business Systems--Definition and...

  2. FAA/NASA En Route Noise Symposium

    NASA Technical Reports Server (NTRS)

    Powell, Clemans A. (Compiler)

    1990-01-01

    Aircraft community noise annoyance is traditionally a concern only in localities near airports. The proposed introduction of large commercial airplanes with advanced turboprop propulsion systems with supersonic propellers has given rise to concerns of noise annoyance in areas previously considered not to be impacted by aircraft noise. A symposium was held to assess the current knowledge of factors important to the impact of en route noise and to aid in the formulation of FAA and NASA programs in the area. Papers were invited on human response to aircraft noise in areas with low ambient noise levels, aircraft noise heard indoors and outdoors, aircraft noise in recreational areas, detection of propeller and jet aircraft noise, and methodological issues relevant to the design of future studies.

  3. The new FAA national automated ECG network: some aviation medical examiner experiences.

    PubMed

    Beers, K N; Mohler, S R

    1991-01-01

    The Federal Aviation Administration (FAA) has required, since August 1, 1987, that aviation medical examiners (AMEs) transmit by telephone all electrocardiograms (ECGs) necessary for airman "Class I" medical certification. This relatively new airman certification requirement is centralized at the Civil Aeromedical Institute (CAMI) in Oklahoma City. In calendar year 1989, the FAA received 69,000 electronically transmitted electrocardiograms. CAMI uses Marquette Electronics software to interpret the ECG signals that are received from multi-channel equipment. The single-channel transmitted ECGs are hand screened at present. The FAA "automated" screening program is unique among governmental airman medical certification programs throughout the world. This paper presents, for potential future users, the authors' experiences with the new airman automated electrocardiographic certification requirement, and covers positive and negative features involved in the implementation and operation of the program. We conclude that while the new FAA automated ECG screening program has satisfactorily replaced the former "physician-intensive" manual screening process, the new system increases the AME's equipment and operation costs. These are passed on to the airman who is seeking certification.

  4. Employee Retirement Income Security Act of 1974: rules and regulations for administration and enforcement; claims procedure. Pension and Welfare Benefits Administration, Labor. Final regulation.

    PubMed

    2000-11-21

    This document contains a final regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). The regulation establishes new standards for the processing of claims under group health plans and plans providing disability benefits and further clarifies existing standards for all other employee benefit plans. The new standards are intended to ensure more timely benefit determinations, to improve access to information on which a benefit determination is made, and to assure that participants and beneficiaries will be afforded a full and fair review of denied claims. When effective, the regulation will affect participants and beneficiaries of employee benefit plans, employers who sponsor employee benefit plans, plan fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  5. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  6. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 5 2011-07-01 2011-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  7. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 5 2013-07-01 2013-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  8. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 5 2014-07-01 2014-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  9. 32 CFR 728.58 - Federal Aviation Agency (FAA) beneficiaries.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 5 2012-07-01 2012-07-01 false Federal Aviation Agency (FAA) beneficiaries. 728.58 Section 728.58 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL... Federal Agencies § 728.58 Federal Aviation Agency (FAA) beneficiaries. (a) Beneficiaries. Air...

  10. Comparison of Intent-to-Leave with Actual Turnover within the FAA

    DTIC Science & Technology

    2006-12-01

    Incentives for early retirement (e.g., “buy-outs”) were offered in 1997 throughout the federal government as part of the shrinking of the federal...workforce under the Clinton administration (National Performance Review, 1993). It is possible that incentives for early retirement inflated the expressed...buy-out” as the primary reason. The FAA did not offer incentives for early retirement in 2000 through 2004. Actual turnover The actual turnover rate

  11. Health Care Financing Administration--Fiscal year 1980 regulation plan. Notice of regulation plan.

    PubMed

    1980-06-12

    HCFA has adopted a new regulation management system which includes a process for developing a regulation plan at the beginning of each fiscal year. Each initiative in the plan is designed to achieve specific programmatic goals and objectives in accordance with priorities. The plan includes a projected schedule for publishing each regulatory initiative in priority order. The annual HCFA plan supplements the Semi-Annual Agenda of Regulations published by HHS in June and December of each year in accordance with Executive Order 12044 "Improving Federal Government Regulations" (See 43 FR 12661 published March 23, 1978), and the Department's procedures which implement the Executive Order (See 43 FR 23119 published May 30, 1978, and 44 FR 59662 published October 16, 1979). The HCFA plan includes: [1] initiatives which appear in the Semi-Annual Agenda of Regulations because HCFA and the Secretary of HHS have concluded that specific regulation changes are needed; [2] new initiatives at an early stage of consideration where HCFA and the Secretary have not yet concluded that specific regulation changes are needed; and [3] routine initiatives that provide guidelines for existing regulations. HCFA is publishing the plan to provide the public with advance notice as early as possible of regulation initiatives that are planned or under active consideration. HCFA welcomes comments on the content of the plan, the priority set for each initiative, and projected publications targets.

  12. FAA Pilot Knowledge Tests: Learning or Rote Memorization?

    NASA Technical Reports Server (NTRS)

    Casner, Stephen M.; Jones, Karen M.; Puentes, Antonio; Irani, Homi

    2004-01-01

    The FAA pilot knowledge test is a multiple-choice assessment tool designed to measure the extent to which applicants for FAA pilot certificates and ratings have mastered a corpus of required aeronautical knowledge. All questions that appear on the test are drawn from a database of questions that is made available to the public. The FAA and others are concerned that releasing test questions may encourage students to focus their study on memorizing test questions. To investigate this concern, we created our own database of questions that differed from FAA questions in four different ways. Our first three question types were derived by modifying existing FAA questions: (1) rewording questions and answers; (2) shuffling answers; and (3) substituting different figures for problems that used figures. Our last question type posed a question about required knowledge for which no FAA question currently exists. Forty-eight student pilots completed one of two paper-and-pencil knowledge tests that contained a mix of these experimental questions. The results indicate significantly lower scores for some question types when compared to unaltered FAA questions to which participants had prior access.

  13. 78 FR 40891 - Revisions to the Export Administration Regulations: Military Vehicles; Vessels of War...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ...This rule adds to the Export Administration Regulations (EAR) controls on military vehicles and related items; vessels of war and related items; submersible vessels, oceanographic equipment and related items; and auxiliary and miscellaneous items that the President has determined no longer warrant control on the United States Munitions List (USML). This rule also adds to the EAR controls on......

  14. 76 FR 75799 - General Administrative Regulations; Mutual Consent Cancellation; Food Security Act of 1985...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... Consent Cancellation; Food Security Act of 1985, Implementation; Denial of Benefits; and Ineligibility for... remove Subpart C--General Administrative Regulations; Mutual Consent Cancellation and Subpart F--Food... quality of the human environment, health, or safety. Therefore, neither an Environmental Assessment nor...

  15. School Administrators' Opinions on Frequently Changing Regulations Related to Appointments and Relocation: A New Model Proposal

    ERIC Educational Resources Information Center

    Sezer, Senol

    2016-01-01

    The purpose of this study is to reveal school administrators' opinions on frequently changing regulations related to appointments and relocation and to offer a new model. A qualitative research design was employed. The study participants were 20 school principals and 20 vice principals working in the Ordu, Giresun and Trabzon city centres during…

  16. 78 FR 76741 - Revisions to the Export Administration Regulations (EAR): Unverified List (UVL)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ...The Bureau of Industry and Security (BIS) is amending the Export Administration Regulations (EAR) by: Requiring exporters to file an Automated Export System (AES) record for all exports subject to the EAR involving a party or parties to the transaction who are listed on the Unverified List (the ``Unverified List'' or UVL); suspending the availability of license exceptions for exports,......

  17. 76 FR 58393 - Updated Statements of Legal Authority for the Export Administration Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... Bureau of Industry and Security 15 CFR Parts 730, 732, 734, 736, 738, 740, 742, 743, 744, 746, 747, 748... of Legal Authority for the Export Administration Regulations AGENCY: Bureau of Industry and Security... Policy Division, Bureau of Industry and Security, Room H2899B, U.S. Department of Commerce,...

  18. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  19. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  20. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  1. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  2. 40 CFR 29.13 - May the Administrator waive any provision of these regulations?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false May the Administrator waive any provision of these regulations? 29.13 Section 29.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES §...

  3. 78 FR 31431 - Export Administration Regulations (EAR): Control of Spacecraft Systems and Related Items the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-24

    ... Administration Regulations (EAR): Control of Spacecraft Systems and Related Items the President Determines No Longer Warrant Control Under the United States Munitions List (USML) AGENCY: Bureau of Industry and... articles the President determines no longer warrant control under United States Munitions List...

  4. 76 FR 12279 - Amendment to the Export Administration Regulations: Application Processing, Issuance, and Denial

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... Export Administration Regulations (EAR) by clarifying the Application Processing, Issuance, and Denial..., and Denial Part 750 of the EAR provides for the revision, suspension or revocation of licenses whenever it is known that the EAR have been violated or that a violation is about to occur. In this...

  5. 78 FR 13675 - Federal Acquisition Regulation; Submission for OMB Review; Cost Accounting Standards Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ... accounting practice change, the total potential impact of the change on contracts containing a CAS provision... Regulation; Submission for OMB Review; Cost Accounting Standards Administration AGENCY: Department of Defense...: Under the provisions of the Paperwork Reduction Act, the Regulatory Secretariat will be submitting...

  6. Complying with Occupational Safety and Health Administration regulations: a guide for compounding pharmacists.

    PubMed

    Mixon, Bill; Nain, John

    2013-01-01

    In the compounding pharmacy, compliance with Occupational Safety and Health Administration regulations is essential to protect employees and customers from exposure to hazardous substances and a dangerous environment, to avert heavy fines and penalties levied for noncompliance, and to fulfill the moral obligation of pharmacists to do no harm. Without adequate vigilance, compounders are vulnerable to lapses in adherence to Occupational Safety and Health Administration requirements, the results of which can be dire in a climate of increased scrutiny about the safety and integrity of pharmaceutical compounding. Proactively addressing necessary compliance with essential safety regulations can only benefit compounders and their staff and clients, and guidance from an expert in Occupational Safety and Health Administration requirements can be a key factor in accomplishing that goal.

  7. 14 CFR 39.21 - Where can I get information about FAA-approved alternative methods of compliance?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Where can I get information about FAA-approved alternative methods of compliance? 39.21 Section 39.21 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS DIRECTIVES § 39.21 Where can I...

  8. 14 CFR 11.27 - Are there other ways FAA collects specific rulemaking recommendations before we issue an NPRM?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Are there other ways FAA collects specific rulemaking recommendations before we issue an NPRM? 11.27 Section 11.27 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES GENERAL RULEMAKING...

  9. 14 CFR 11.23 - Does FAA follow the same procedures in issuing all types of rules?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Does FAA follow the same procedures in issuing all types of rules? 11.23 Section 11.23 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES GENERAL RULEMAKING PROCEDURES Rulemaking Procedures...

  10. Prohibited or regulated? LSD psychotherapy and the United States Food and Drug Administration.

    PubMed

    Oram, Matthew

    2016-09-01

    Over the 1950s and early 1960s, the use of the hallucinogenic drug lysergic acid diethylamide (LSD) to facilitate psychotherapy was a promising field of psychiatric research in the USA. However, during the 1960s, research began to decline, before coming to a complete halt in the mid-1970s. This has commonly been explained through the increase in prohibitive federal regulations during the 1960s that aimed to curb the growing recreational use of the drug. However, closely examining the Food and Drug Administration's regulation of LSD research in the 1960s will reveal that not only was LSD research never prohibited, but that the administration supported research to a greater degree than has been recognized. Instead, the decline in research reflected more complex changes in the regulation of pharmaceutical research and development.

  11. 76 FR 2745 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Eighty-Fourth Meeting: RTCA Special Committee 159: Global Positioning System (GPS) AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of RTCA Special...

  12. 77 FR 64837 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Federal Aviation Administration Fourth Meeting: RTCA Special Committee 227, Standards of Navigation Performance AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION... 15, 2012. Kathy Hitt, Management Analyst, Business Operations Group, Federal Aviation...

  13. Compliance with the new Food and Drug Administration regulations: an approach by industry.

    PubMed

    Ward, J W

    1981-09-01

    Good Laboratory Practice regulations became effective on June 20, 1979. The regulations provide guidance for the proper conduct and reporting of nonclinical laboratory studies on articles regulated by the United States Food and Drug Administration. A fundamental requirement of the regulations is the establishment of a quality assurance unit within each research facility to ensure the utilization and maintenance of good laboratory practices. A second significant feature is the requirement for an archival unit responsible for maintaining all raw data, documentation, protocols, specimens, and final reports. Experience with the regulations has been mixed. The quality of reports has been upgraded dramatically. Protocols contain more information than ever, data recording is more extensive and more carefully executed, and reports are prepared more carefully and edited more thoroughly. Conversely, there is no real evidence that quality of science has been improved, and costs have increased markedly.

  14. Overview of composite projects at the FAA Airworthiness Assurance Validation Center

    SciTech Connect

    Shurtleff, W.W.; Roach, D.P.; Valley, M.T.

    1997-03-01

    The Airworthiness Assurance NDI Validation Center (AANC) was established by the Federal Aviation Administration (FAA) William J. Hughes Technical Center at Sandia National Laboratories in 1991 to support nondestructive inspection (NDI) technology development and assessment. The evaluations are done using a variety of characterized test specimens and test beds including entire transport and commuter aircraft. Although the initial work at the Center concentrated on metallic structure, the FAA has more recently expanded the AANC`s charter to include projects directed at composite repair and inspection. The three projects briefly described in this paper are: (1) the validation and technology transfer of a thermographic techniques for composite inspection, (2) the development of generic composite laminate and honeycomb calibration reference standards, and (3) the certification of the use of boron epoxy doubler on a Lockheed L-1011.

  15. FAA certification requirements for future fuels, fuel systems and powerplants

    NASA Technical Reports Server (NTRS)

    Horeff, T. C.

    1983-01-01

    The current FAA procedures for approving fuels, along with a comment or two as to what might be done relative to assuring the safety of using these alternative fuels, whatever they may be are addressed.

  16. Evaluation of Proposed Cab Glass Coating for FAA Control Towers

    DTIC Science & Technology

    2013-12-01

    wear vision correction? None Contacts Glasses Both If required, which correction do you use: Monofocal Bifocal Trifocal Color perception results...i AFRL-RH-WP-TR-2013-0123 Evaluation of Proposed Cab Glass Coating for FAA Control Towers Eric E. Geiselman Alan R. Pinkus, Ph.D...COVERED (From - To) 30-12-2013 Final Jun 2012 – Jun 2013 4. TITLE AND SUBTITLE Evaluation of Proposed Cab Glass Coating for FAA Control

  17. Aviation Safety: FAA and DOD Response to Similar Safety Concerns

    DTIC Science & Technology

    2002-01-01

    General Accounting Office GAO January 2002 AVIATION SAFETY FAA and DOD Response to Similar Safety Concerns GAO-02-77 Report Documentation Page Report...Date 00JAN2002 Report Type N/A Dates Covered (from... to) - Title and Subtitle AVIATION SAFETY FAA and DOD: Response to Similar Safety Concerns ...public release, distribution unlimited Supplementary Notes Abstract Safety of aircraft is a paramount concern in both civilian and military aviation

  18. FAA Rotorcraft Research, Engineering, and Development Bibliography 1962-1989

    DTIC Science & Technology

    1990-05-01

    81-4 Comprehensive Bibliography of Literature on Helicopter Noise Technology (A.M. Carter, Jr.) (NTIS: ADA 103 331) FAA-RD-75-79 Comprehensive Review...Engineering and Development Program Plan, Aircraft Icing FAA-CT-81-180 Engineering and Development Program Plan, Helicopter Icing Technology Research (NTIS: ADA...of Various NASA CR-177408 Simulation Technology Options for Terminal Instrument Procedures (TERPS) Enhancements (Anil V. Phatak, John A. Sorensen

  19. 41 CFR 102-37.530 - What are FAA's responsibilities in the donation of surplus property to public airports?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... responsibilities in the donation of surplus property to public airports? 102-37.530 Section 102-37.530 Public... MANAGEMENT REGULATION PERSONAL PROPERTY 37-DONATION OF SURPLUS PERSONAL PROPERTY Donations to Public Airports § 102-37.530 What are FAA's responsibilities in the donation of surplus property to public airports?...

  20. 15 CFR § 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2010 CFR

    2015-01-01

    ... 15 Commerce and Foreign Trade 2 2015-01-01 2015-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). § 772.1 Section § 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION...

  1. 15 CFR § 772.1 - Definitions of terms as used in the Export Administration Regulations (EAR).

    Code of Federal Regulations, 2010 CFR

    2016-01-01

    ... 15 Commerce and Foreign Trade 2 2016-01-01 2016-01-01 false Definitions of terms as used in the Export Administration Regulations (EAR). § 772.1 Section § 772.1 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION...

  2. Upgraded FAA Airfield Capacity Model Compiled from the Following Reports: FAA-RD-76-128 and FAA-EM-81-1-VOL-1

    DTIC Science & Technology

    1981-05-01

    mental User’s Guide," provides a general overview of the major changes that have been made to the program and includes revised versions of the...Arrival-Arrival Separations: DLTAIJ: 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 103 ** FAA CAPACITY MODEL - REVISED JANUARY, 1980 ** "t AIRFIELD HOURLY CAPACITY MODELO

  3. Integration of structural health monitoring solutions onto commercial aircraft via the Federal Aviation Administration structural health monitoring research program

    NASA Astrophysics Data System (ADS)

    Swindell, Paul; Doyle, Jon; Roach, Dennis

    2017-02-01

    The Federal Aviation Administration (FAA) started a research program in structural health monitoring (SHM) in 2011. The program's goal was to understand the technical gaps of implementing SHM on commercial aircraft and the potential effects on FAA regulations and guidance. The program evolved into a demonstration program consisting of a team from Sandia National Labs Airworthiness Assurance NDI Center (AANC), the Boeing Corporation, Delta Air Lines, Structural Monitoring Systems (SMS), Anodyne Electronics Manufacturing Corp (AEM) and the FAA. This paper will discuss the program from the selection of the inspection problem, the SHM system (Comparative Vacuum Monitoring-CVM) that was selected as the inspection solution and the testing completed to provide sufficient data to gain the first approved use of an SHM system for routine maintenance on commercial US aircraft.

  4. FAA Fluorescent Penetrant Activities - An Update

    SciTech Connect

    Moore, D.G.

    1998-10-20

    The Federal Aviation Administration's Airworthiness Assurance NDI Validation Center (AANC) is currently characterizing low cycle fatigue specimens that will support the needs of penetrant manufacturers, commercial airline industry and the Federal Aviation Administration. The main focus of this characterization is to maintain and enhance the evaluation of penetrant inspection materials and apply resources to support the aircraft community needs. This paper discusses efforts to-date to document the Wright Laboratory penetrant evaluation process and characterize penetrant brightness readings in the initial set of sample calibration panels using Type 1 penetrant.

  5. Collegiate Aviation and FAA Air Traffic Control.

    ERIC Educational Resources Information Center

    Ruiz, Jose R.; Ruiz, Lorelei E.

    2003-01-01

    Based on a literature review this article describes the Air Traffic-Collegiate Training Initiative (AT-CTI) program, including objectives, the process by which postsecondary institutes become affiliated, advantages of affiliation, and the recruitment and employment of air traffic control graduates by the Federal Aviation Administration. (Contains…

  6. The infralimbic cortex regulates the consolidation of extinction after cocaine self-administration.

    PubMed

    LaLumiere, Ryan T; Niehoff, Kate E; Kalivas, Peter W

    2010-04-01

    The infralimbic cortex (IL) regulates the consolidation of extinction learning for fear conditioning. Whether the IL influences the consolidation of extinction learning for cocaine self-administration is unknown. To address this issue, male Sprague-Dawley rats underwent 2 wk of cocaine self-administration followed by extinction training. On the first 5 d of extinction, rats underwent brief (15- or 30-min) extinction sessions and received intra-IL microinjections immediately after each extinction session. On days 6-12 of extinction, rats underwent full-length (2-h) extinction sessions that were used to assess the retention of the extinction learning from the short sessions. IL inactivation via microinjections of the GABA agonists baclofen and muscimol (BM) immediately after the extinction sessions (days 1-5) impaired the retention of extinction learning. Control experiments demonstrated that this effect was not due to inactivation of the prelimbic cortex or due to effects of the drugs on the subsequent day's behavior. In contrast, post-training intra-IL microinjections of the allosteric AMPA receptor potentiator 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetamide (PEPA) enhanced retention of the extinction learning. As evidence suggests a role for the beta-adrenergic receptors in memory consolidation, other rats received microinjections of the beta(2)-adrenergic receptor agonist clenbuterol or antagonist ICI-118,551 (ICI). Post-training intra-IL administration of clenbuterol or pre-training administration of ICI enhanced or impaired, respectively, the retention of extinction learning. These data indicate that the IL, and specifically the glutamatergic and beta-adrenergic systems in the IL, regulates the consolidation of extinction of cocaine self-administration and that the IL can be manipulated to influence the retention of extinction.

  7. 14 CFR 406.177 - Petition to reconsider or modify a final decision and order of the FAA decisionmaker on appeal.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Petition to reconsider or modify a...

  8. 14 CFR 406.177 - Petition to reconsider or modify a final decision and order of the FAA decisionmaker on appeal.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Petition to reconsider or modify a...

  9. 14 CFR 406.177 - Petition to reconsider or modify a final decision and order of the FAA decisionmaker on appeal.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Petition to reconsider or modify a...

  10. 14 CFR 406.177 - Petition to reconsider or modify a final decision and order of the FAA decisionmaker on appeal.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Petition to reconsider or modify a...

  11. 14 CFR 406.177 - Petition to reconsider or modify a final decision and order of the FAA decisionmaker on appeal.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space Transportation... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Petition to reconsider or modify a...

  12. Implementing International Health Regulation (2005) in the Brazilian legal-administrative system.

    PubMed

    Lima, Yara Oyram Ramos; Costa, Ediná Alves

    2015-06-01

    The scope of this study was to analyze how the International Sanitary Regulation (ISR 2005)has been incorporated into the Brazilian legal-administrative system, in relation to sanitary control measures involving freight, means of transportation and travelers and possible alterations to health surveillance activities, competencies and procedures. This case study has been undertaken using a qualitative approach, of a descriptive and exploratory nature, using institutional data sources and interviews with key-informants involved in implementing ISR (2005). Alterations to the Brazilian legal-administrative system resulting from ISR (2005) were identified, in relation to standards, special competencies and procedures relating to sanitary controls for freight, modes of transportation and travelers. In its present form, the International Sanitary Regulation is an instrument that, in addition to introducing new international and national sanitary control concepts and elements, also helps to clarify questions that are helpful on a national level, relating to the specific competencies and procedures which will, to a certain extent, put pressure on administrative structures in the areas of sanitary control and surveillance.

  13. Further amendments to general regulations of the Food and Drug Administration to incorporate tobacco products. Final rule.

    PubMed

    2012-02-02

    The Food and Drug Administration (FDA) is amending certain of its general regulations to include tobacco products, where appropriate, in light of FDA's authority to regulate these products under the Family Smoking Prevention and Tobacco Control Act (Tobacco Control Act). With these amendments, tobacco products are subject to the same general requirements that apply to other FDA-regulated products.

  14. Impact of new Food and Drug Administration regulations on college, university, and experiment station researchers.

    PubMed

    Willett, L B

    1981-09-01

    The Good Laboratory Practice regulations adopted by the Food and Drug Administration describe specific procedures to assure the integrity of the research results. Those studies conducted with the intent to provide data on the safety of drugs and chemicals will be required to comply with the published relations. The process of bringing research laboratories into compliance with the regulations may be either arduous or fairly routine depending on the organization, goals, and type of research. Typically, the Good Laboratory Practice regulations will increase sharply the cost of health safety information. Hiring more and better trained technical and professional personnel will be much of this expense. If university and experiment station researchers choose to avoid compliance with these regulations, then agricultural research science may not continue to be recognized as an authority on the safety of products used for production of human food. Irrespective of whether universities choose to conduct regulated research or delegate this role to other segments of society, academic institutions must assume the role of training those individuals needed to conduct toxicity research.

  15. Evaluating the compliance of Keck's LGSAO automated aircraft protection system with FAA adopted criteria

    NASA Astrophysics Data System (ADS)

    Stomski, Paul J.; Campbell, Randy; Murphy, Thomas W.

    2014-07-01

    The W. M. Keck Observatory (WMKO) applied for and received a determination of no-objection from the Federal Aviation Administration (FAA) for laser guide star adaptive optics (LGS-AO) operations using an automated aircraft protection system (APS) in late 2013. WMKO's APS, named AIRSAFE, uses transponder based aircraft detection (TBAD) to replace human aircraft spotters. The FAA required WMKO to self-certify AIRSAFE compliance with SAE Aerospace Standard 6029A: "Performance Criteria for Laser Control Measures Used for Aviation Safety"[1] (AS- 6029A). AS-6029A prescribes performance and administrative criteria for an APS; essentially, requiring AIRSAFE to adequately protect all types of aircraft, traveling at any speed, altitude, distance and direction reasonably expected in the operating environment. A description of the analysis that comprises this compliance evaluation is the main focus of this paper. Also discussed is the AIRSAFE compliance with AS-6029A administrative criteria that includes characterization of site specific air traffic, failure modes, limitations, operating procedures, preventative maintenance procedures, and periodic system test procedures.

  16. US Food and Drug Administration international collaborations for cellular therapy product regulation

    PubMed Central

    2012-01-01

    Cellular therapy products are an emerging medical product class undergoing rapid scientific and clinical innovation worldwide. These products pose unique regulatory challenges both for countries with existing regulatory frameworks and for countries where regulatory frameworks for cellular therapy products are under development. The United States Food and Drug Administration (US FDA) has a history of productive working relationships with international regulatory authorities, and seeks to extend this to the cellular therapy field. The US FDA and its global regulatory counterparts are engaged in collaborations focused on the convergence of scientific and regulatory approaches, and the education of scientists, clinicians, regulators, and the public at large on the development of cellular therapies. PMID:23021082

  17. United States Food and Drug Administration Regulation of Gene and Cell Therapies.

    PubMed

    Bailey, Alexander M; Arcidiacono, Judith; Benton, Kimberly A; Taraporewala, Zenobia; Winitsky, Steve

    2015-01-01

    The United States (US) Food and Drug Administration (FDA) is a regulatory agency that has oversight for a wide range of products entering the US market, including gene and cell therapies. The regulatory approach for these products is similar to other medical products within the United States and consists of a multitiered framework of statutes, regulations, and guidance documents. Within this framework, there is considerable flexibility which is necessary due to the biological and technical complexity of these products in general. This chapter provides an overview of the US FDA regulatory oversight of gene and cell therapy products.

  18. Assessment of Proposed Cab Glass Coating for FAA Control Towers

    DTIC Science & Technology

    2015-11-16

    ABSTRACT AFRL assessed the effects of an "after- market " coating that could possibly be applied to FAA air traffic control tower (ATCT) windows...Force Research Laboratory (AFRL) for help in assessing the effects of an "after- market " glass coating/treatment that could possibly be applied to FAA...Cleared 01/17/2014; 88ABW-2014-0142. Report contains color. 14. ABSTRACT AFRL assessed the effects of an "after- market " coating that could possibly be

  19. Grants for graduate programs in health administration and grants for traineeships in health administration--PHS. Amendments to final regulations.

    PubMed

    1984-05-22

    These amendments conform provisions in 42 CFR Part 58, Subpart A, "Grants for Graduate Programs in Health Administration," and Subpart D, entitled "Grants for Traineeships in Health Administration, Hospital Administration, or Health Policy Analysis and Planning at Public or Nonprofit Private Educational Institutions Other Than Schools of Public Health" to statutory amendments made by the Orphan Drug Act, Pub . L. 97-414: the Omnibus Budget Reconciliation Act of 1981, Pub . L. 97-35; and Pub . L. 94-241, the Commonwealth-- Covenant to Establish--Northern Mariana Islands.

  20. Aviation Maintenance Technology. Course Content Guides. FAA Approved Curriculum.

    ERIC Educational Resources Information Center

    Shrawder, Jack; And Others

    Course content guides are provided for the 30 courses in this aviation maintenance technology curriculum approved by the Federal Aviation Administration. Course titles are physics for technicians; aircraft information, regulations, and procedures; aircraft assembly; fundamentals of aircraft electronics; aircraft electrical components; aircraft…

  1. Neural circuitry of emotion regulation: Effects of appraisal, attention, and cortisol administration.

    PubMed

    Ma, Sean T; Abelson, James L; Okada, Go; Taylor, Stephan F; Liberzon, Israel

    2017-04-01

    Psychosocial well-being requires effective regulation of emotional responding in context of threat or stress. Neuroimaging studies have focused on instructed, volitional regulation (e.g., reappraisal or distancing), largely ignoring implicit regulation that does not involve purposeful effort to alter emotional experience. These implicit processes may or may not involve the same neural pathways as explicit regulatory strategies. We examined the neurobiology of implicit emotional regulation processes and the impact of the stress hormone cortisol on these processes. Our study task employed composite pictures of faces and places to examine neural activity during implicit emotional processing (of emotional faces), while these responses were implicitly regulated by attention shift away from the emotionally evocative stimuli, and while subjects reflectively appraised their own emotional response to them. Subjects completed the task in an fMRI scanner after random assignment to receive placebo or hydrocortisone (HCT), an orally administered version of cortisol. Implicit emotional processing activated insula/IFG, dACC/dMPFC, midbrain and amygdala. With attention shifting, we saw diminished signal in emotion generating/response regions (e.g., amygdala) and increased activations in task specific attention regions like parahippocampus. With appraisal of emotions, we observed robust activations in medial prefrontal areas, where activation is also seen in instructed reappraisal studies. We observed no main effects of HCT administration on brain, but males and females showed opposing neural effects in prefrontal areas. The data suggest that different types of emotion regulation utilize overlapping circuits, but with some strategy specific activation. Further study of the dimorphic sex response to cortisol is needed.

  2. FAA Information Technology: Complete Cost Data not Provided to OMB

    DTIC Science & Technology

    1991-01-01

    and use of information technology . However, FAA has not provided required data on information technology supporting the air traffic control system...decisionmakers in the Department of Transportation, OMB, and the Congress to focus needed attention on information technology and understates the level

  3. FAA Aviation Forecasts, Fiscal Years 1994-2005

    DTIC Science & Technology

    1994-03-01

    Concord, CA (CCR) Santa Barbara, CA (SBA) El Monte, CA (EMT) Santa Maria Public, CA (SMX) H-1 FAA TOWERED AIRPORTS Santa Monica, CA (SMO) Sanford, Fl...Juan Isla Grande, PR (SIG) Kwajalein AAF, WK (KWA) Pago Pago International, AS (TUT) H-6 APPENDIX I CONTRACT TOWERS 1. Flagstaff, Arizona (FLG) 2

  4. Tobacco advertising and sales practices in licensed retail outlets after the Food and Drug Administration regulations.

    PubMed

    Frick, Ryan G; Klein, Elizabeth G; Ferketich, Amy K; Wewers, Mary Ellen

    2012-10-01

    To assess retailer compliance with Food and Drug Administration (FDA) regulations on tobacco sales and advertising practices, including point-of-sale advertisements, in two distinct Columbus, Ohio neighborhood groups by income. Data were gathered from a random sample of 129 licensed tobacco retailers, which included data on both exterior and interior advertisements as well as sales practices. Descriptive analyses compared retail outlets by high and low income neighborhood locations. Compliance with FDA regulations was high in the random sample of urban tobacco retail outlets. None of the retail outlets sold loose cigarettes or offered free items with purchase. Less than 10% of the outlets surveyed offered self-service access to cigarettes or smokeless tobacco products. From all surveyed retail outlets 95% had cigarette, 57% had smokeless, and 57% had cigar advertisements at the point-of-sale. There were no significant differences in compliance by income, but the mean number of advertisements on the building and self-service access to cigars was significantly different by neighborhood income. There was a high degree of compliance with the new FDA regulation on tobacco marketing and sales practices in urban retail tobacco outlets in Columbus, Ohio. Tobacco advertising and marketing remain highly prevalent in retail outlets, with some significant differences between high and low income neighborhoods.

  5. Regulation of hypnosis in Propofol anesthesia administration based on non-linear control strategy.

    PubMed

    Ilyas, Muhammad; Khaqan, Ali; Iqbal, Jamshed; Riaz, Raja Ali

    Continuous adjustment of Propofol in manual delivery of anesthesia for conducting a surgical procedure overburdens the workload of an anesthetist who is working in a multi-tasking scenario. Going beyond manual administration and Target Controlled Infusion, closed-loop control of Propofol infusion has the potential to offer several benefits in terms of handling perturbations and reducing the effect of inter-patient variability. This paper proposes a closed-loop automated drug administration approach to control Depth Of Hypnosis in anesthesia. In contrast with most of the existing research on anesthesia control which makes use of linear control strategies or their improved variants, the novelty of the present research lies in applying robust control strategy i.e. Sliding Mode Control to accurately control drug infusion. Based on the derived patient's model, the designed controller uses measurements from EEG to regulate DOH on Bispectral Index by controlling infusion rate of Propofol. The performance of the controller is investigated and characterized with real dataset of 8 patients undergoing surgery. Results of this in silico study indicate that for all the patients, with 0% overshoot observed, the steady state error lies in between ±5. Clinically, this implies that in all the cases, without any overdose, the controller maintains the desired DOH level for smooth conduction of surgical procedures.

  6. [Regulation of hypnosis in Propofol anesthesia administration based on non-linear control strategy].

    PubMed

    Ilyas, Muhammad; Khaqan, Ali; Iqbal, Jamshed; Riaz, Raja Ali

    Continuous adjustment of Propofol in manual delivery of anesthesia for conducting a surgical procedure overburdens the workload of an anesthetist who is working in a multi-tasking scenario. Going beyond manual administration and Target Controlled Infusion, closed-loop control of Propofol infusion has the potential to offer several benefits in terms of handling perturbations and reducing the effect of inter-patient variability. This paper proposes a closed-loop automated drug administration approach to control Depth Of Hypnosis in anesthesia. In contrast with most of the existing research on anesthesia control which makes use of linear control strategies or their improved variants, the novelty of the present research lies in applying robust control strategy i.e. Sliding Mode Control to accurately control drug infusion. Based on the derived patient's model, the designed controller uses measurements from EEG to regulate DOH on Bispectral Index by controlling infusion rate of Propofol. The performance of the controller is investigated and characterized with real dataset of 8 patients undergoing surgery. Results of this in silico study indicate that for all the patients, with 0% overshoot observed, the steady state error lies in between ±5. Clinically, this implies that in all the cases, without any overdose, the controller maintains the desired DOH level for smooth conduction of surgical procedures.

  7. CRF-Amplified Neuronal TLR4/MCP-1 Signaling Regulates Alcohol Self-Administration

    PubMed Central

    June, Harry L; Liu, Juan; Warnock, Kaitlin T; Bell, Kimberly A; Balan, Irina; Bollino, Dominique; Puche, Adam; Aurelian, Laure

    2015-01-01

    Alcohol dependence is a complex disorder that initiates with episodes of excessive alcohol drinking known as binge drinking. It has a 50–60% risk contribution from inherited susceptibility genes; however, their exact identity and function are still poorly understood. We report that alcohol-preferring P rats have innately elevated levels of Toll-like receptor 4 (TLR4) and monocyte chemotactic protein-1 (MCP-1) that colocalize in neurons from the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA). To examine the potential role of a TLR4/MCP-1 signal, we used Herpes Simplex Virus (HSV) vectors (amplicons) that retain in vivo neurotropism. Infusion of amplicons for TLR4 or MCP-1 siRNA into the CeA or VTA from the P rats inhibited target gene expression and blunted binge drinking. A similarly delivered amplicon for scrambled siRNA did not inhibit TLR4 or MCP-1 expression nor reduce binge drinking, identifying a neuronal TLR4/MCP-1 signal that regulates the initiation of voluntary alcohol self-administration. The signal was sustained during alcohol drinking by increased expression of corticotropin-releasing factor and its feedback regulation of TLR4 expression, likely contributing to the transition to alcohol dependence. PMID:25567426

  8. 76 FR 44978 - Notice of FAA Intent To Carry Over Airport Improvement Program (AIP) Entitlement Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ...-0786] Notice of FAA Intent To Carry Over Airport Improvement Program (AIP) Entitlement Funds AGENCY... Program (AIP) must notify, in writing, the designated representative in the appropriate FAA Regional or... grants to the following year. In such cases, the FAA converts the current-year funds to AIP...

  9. GIS and RDBMS Used with Offline FAA Airspace Databases

    NASA Technical Reports Server (NTRS)

    Clark, J.; Simmons, J.; Scofield, E.; Talbott, B.

    1994-01-01

    A geographic information system (GIS) and relational database management system (RDBMS) were used in a Macintosh environment to access, manipulate, and display off-line FAA databases of airport and navigational aid locations, airways, and airspace boundaries. This proof-of-concept effort used data available from the Adaptation Controlled Environment System (ACES) and Digital Aeronautical Chart Supplement (DACS) databases to allow FAA cartographers and others to create computer-assisted charts and overlays as reference material for air traffic controllers. These products were created on an engineering model of the future GRASP (GRaphics Adaptation Support Position) workstation that will be used to make graphics and text products for the Advanced Automation System (AAS), which will upgrade and replace the current air traffic control system. Techniques developed during the prototyping effort have shown the viability of using databases to create graphical products without the need for an intervening data entry step.

  10. [Determination of palladium in automobile exhaust catalysts by FAAS method].

    PubMed

    Wei, Xiao-Feng; Cai, Guo-Hui; Xiao, Yi-Hong; Zhan, Ying-Ying; Xie, Zeng-Hong; Wei, Ke-Mei

    2009-12-01

    Palladium in automotive exhaust catalyst was determined by flame atomic absorption spectrometry (FAAS). The analytical conditions and the coexisting elements interference were studied. The catalyst was dissolved by the mixture of H2O2 and HCl. Pd in the solution was directly determined by FAAS method. The linearity of working curve ranges from 0.1 to 15 microg x mL(-1); the detection limit is 0.029 microg x mL(-1); the relative standard deviation (RSD) range is from 0.8% to 2.5%; and the recovery rate range is from 99.6% to 101.2%. It is a simple and convenient method for accurate analysis of Pd in the exhaust catalysts.

  11. First Annual FAA General Aviation Forecast Conference Proceedings

    DTIC Science & Technology

    1991-03-01

    pilot’s perspective. I have a 30-year background as an executive in communications, principally in television , but I am also an aircraft owner and have...contrasting this with the business I came from -- television , which is gauged and governed by the TV rating business, which includes overnight ratings. We...ago following the Ceritos, California midair collision between a general aviation aircraft and a Mexicana airliner, the FAA released a study calling for

  12. FAA Weather Surveillance Requirements in the Context on NEXRAD.

    DTIC Science & Technology

    1982-11-19

    7 AD-A123 876 AA WEATHER SUR VE" ANCE REQUIMENTS. HE CONTE T ON i/ NEXRAD (U) MASSACHUSETTS NST OF TECH EXINGTO N LINCO N JD LAS B G LAIRD ET 1 9 NOV...identified technical uncertainties in the NEXRAD atrawman design for FAA applications. The suggested research and development program includes an...automated display and short term prediction of hazardotus weather regions for use by ATC controllers. 17. Kam Wattl is. OlsatdaW sast NEXRAD

  13. Runways at small airports are deteriorating because of deferred maintenance: Action needed by FAA and the Congress

    NASA Astrophysics Data System (ADS)

    1982-09-01

    Runways at many small airports are deteriorating faster than necessary because airport owners--usually local governments--have deferred critical maintenance. The result is damage to the runways' basic structure and a shortened useful life if they are not repaired. Based on GAO's review of 46 airports, studies by others, and the views of FAA officials, deferred maintenance is apparently a longstanding nationwide problem. Lack of funds is cited by airport owners as the primary reason for not performing needed maintenance; however, the Federal Aviation Administration's apathy to bring about satisfactory maintenance is a contributing cause. GAO is recommending actions that FAA can take to help ensure that runways at small airports are properly maintained. The Congress should recognize the airport owners' lack of resources to properly maintain airports when considering future revisions to the Airport Improvement Program.

  14. The FAA's postmortem forensic toxicology self-evaluated proficiency test program: the second seven years.

    PubMed

    Chaturvedi, Arvind K; Craft, Kristi J; Cardona, Patrick S; Rogers, Paul B; Canfield, Dennis V

    2009-05-01

    During toxicological evaluations of samples from fatally injured pilots involved in civil aviation accidents, a high degree of quality control/quality assurance (QC/QA) is maintained. Under this philosophy, the Federal Aviation Administration (FAA) started a forensic toxicology proficiency-testing (PT) program in July 1991. In continuation of the first seven years of the PT findings reported earlier, PT findings of the next seven years are summarized herein. Twenty-eight survey samples (12 urine, 9 blood, and 7 tissue homogenate) with/without alcohols/volatiles, drugs, and/or putrefactive amine(s) were submitted to an average of 31 laboratories, of which an average of 25 participants returned their results. Analytes in survey samples were correctly identified and quantitated by a large number of participants, but some false positives of concern were reported. It is anticipated that the FAA's PT program will continue to serve the forensic toxicology community through this important part of the QC/QA for laboratory accreditations.

  15. Food and drug administration regulation of drugs that raise blood pressure.

    PubMed

    Blankfield, Robert P; Iftikhar, Imran H

    2015-01-01

    Although it is recognized that a systolic blood pressure (SBP) increase ≥ 2 mm Hg or a diastolic blood pressure (DBP) increase ≥ 1 mm Hg increases the risk of heart attacks and strokes in middle-aged adults, the Food and Drug Administration (FDA) lacks an adequate policy for regulating medications that increase blood pressure (BP). Some FDA reviewers consider a clinically significant increase in BP to occur only if a drug raises SBP ≥ 20 mm Hg or if a drug raises DBP ≥ 10 to 15 mm Hg. In recent years, numerous drugs have been regulated or taken off the market due to cardiovascular safety concerns. The list includes rofecoxib (Vioxx), valdecoxib (Bextra), nonselective nonsteroidal anti-inflammatory drugs, sibutramine (Meridia), and phenylpropanolamine. It is probable that the hypertensive effect of these drugs explains why they increase the risk of adverse cardiovascular events. Other drugs, notably serotonin-norepinephrine reuptake inhibitors and drugs used to treat attention deficit hyperactivity disorder, were approved without cardiovascular safety data despite the fact that they raise BP comparable to valdecoxib and sibutramine. It is the responsibility of the FDA to ensure that drugs are properly labeled regarding risk. Even if a drug raises BP only modestly, FDA guidelines for new drug approvals should include a requirement for cardiovascular safety data. However, such guidelines will not address the problem of how to obtain cardiovascular safety data for the many already approved drugs that increase BP. The FDA should play a role in obtaining cardiovascular safety data for such drugs.

  16. Serotonin-3 receptors in the posterior ventral tegmental area regulate ethanol self-administration of alcohol-preferring (P) rats.

    PubMed

    Rodd, Zachary A; Bell, Richard L; Oster, Scott M; Toalston, Jamie E; Pommer, Tylene J; McBride, William J; Murphy, James M

    2010-05-01

    Several studies indicated the involvement of serotonin-3 ([5-hydroxy tryptamine] 5-HT(3)) receptors in regulating alcohol-drinking behavior. The objective of this study was to determine the involvement of 5-HT(3) receptors within the ventral tegmental area (VTA) in regulating ethanol self-administration by alcohol-preferring (P) rats. Standard two-lever operant chambers (Coulbourn Instruments, Allentown, PA) were used to examine the effects of seven consecutive bilateral microinfusions of ICS 205-930 (ICS), a 5-HT(3) receptor antagonist, directly into the posterior VTA on the acquisition and maintenance of 15% (vol/vol) ethanol self-administration. P rats readily acquired ethanol self-administration by the fourth session. The three highest doses (0.125, 0.25, and 1.25 microg) of ICS prevented acquisition of ethanol self-administration. During the acquisition postinjection period, all rats treated with ICS demonstrated higher responding on the ethanol lever, with the highest dose producing the greatest effect. In contrast, during the maintenance phase, the three highest doses (0.75, 1.0, and 1.25 microg) of ICS significantly increased responding on the ethanol lever; after the 7-day dosing regimen, responding on the ethanol lever returned to control levels. Microinfusion of ICS into the posterior VTA did not alter the low responding on the water lever and did not alter saccharin (0.0125% wt/v) self-administration. Microinfusion of ICS into the anterior VTA did not alter ethanol self-administration. Overall, the results of this study suggest that 5-HT(3) receptors in the posterior VTA of the P rat may be involved in regulating ethanol self-administration. In addition, chronic operant ethanol self-administration and/or repeated treatments with a 5-HT(3) receptor antagonist may alter neuronal circuitry within the posterior VTA.

  17. 77 FR 69768 - General Services Administration Acquisition Regulation (GSAR); Rewrite of Part 504...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ...); Rewrite of Part 504, Administrative Matters; Correction AGENCY: Office of Acquisition Policy, General... Administrative Matters. The final rule contained a typographical error which needs to be corrected. DATES... amendment: PART 504--ADMINISTRATIVE MATTERS 0 1. The authority citation for 48 CFR part 504 continues...

  18. 41 CFR 102-33.230 - May we use military FSCAP on non-military FAA-type certificated Government aircraft?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... FSCAP on non-military FAA-type certificated Government aircraft? 102-33.230 Section 102-33.230 Public... certificated Government aircraft? You may use dual-use military FSCAP on non-military aircraft operated under... MANAGEMENT REGULATION PERSONAL PROPERTY 33-MANAGEMENT OF GOVERNMENT AIRCRAFT Managing Government......

  19. 41 CFR 102-33.230 - May we use military FSCAP on non-military FAA-type certificated Government aircraft?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... FSCAP on non-military FAA-type certificated Government aircraft? 102-33.230 Section 102-33.230 Public... certificated Government aircraft? You may use dual-use military FSCAP on non-military aircraft operated under... MANAGEMENT REGULATION PERSONAL PROPERTY 33-MANAGEMENT OF GOVERNMENT AIRCRAFT Managing Government......

  20. 41 CFR 102-33.230 - May we use military FSCAP on non-military FAA-type certificated Government aircraft?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... FSCAP on non-military FAA-type certificated Government aircraft? 102-33.230 Section 102-33.230 Public... certificated Government aircraft? You may use dual-use military FSCAP on non-military aircraft operated under... MANAGEMENT REGULATION PERSONAL PROPERTY 33-MANAGEMENT OF GOVERNMENT AIRCRAFT Managing Government......

  1. 41 CFR 102-33.230 - May we use military FSCAP on non-military FAA-type certificated Government aircraft?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FSCAP on non-military FAA-type certificated Government aircraft? 102-33.230 Section 102-33.230 Public... certificated Government aircraft? You may use dual-use military FSCAP on non-military aircraft operated under... MANAGEMENT REGULATION PERSONAL PROPERTY 33-MANAGEMENT OF GOVERNMENT AIRCRAFT Managing Government......

  2. 41 CFR 102-33.230 - May we use military FSCAP on non-military FAA-type certificated Government aircraft?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... FSCAP on non-military FAA-type certificated Government aircraft? 102-33.230 Section 102-33.230 Public... certificated Government aircraft? You may use dual-use military FSCAP on non-military aircraft operated under... MANAGEMENT REGULATION PERSONAL PROPERTY 33-MANAGEMENT OF GOVERNMENT AIRCRAFT Managing Government......

  3. 78 FR 25524 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... TRANSPORTATION Federal Aviation Administration Notice of Request To Release Airport Property AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Intent to Rule on Request to Release Airport Property..., Airports Compliance Specialist, Federal Aviation Administration, Airports Division, ACE- 610C, 901...

  4. FAA/NASA Joint University Program for Air Transportation Research, 1992-1993

    NASA Technical Reports Server (NTRS)

    Morrell, Frederick R. (Compiler)

    1994-01-01

    The research conducted during the academic year 1992-1993 under the FAA/NASA sponsored Joint University Program for Air Transportation Research is summarized. The year end review was held at Ohio University, Athens, Ohio, 17-18 June 1993. The Joint University Program is a coordinated set of three grants sponsored by the Federal Aviation Administration and NASA Langley Research Center, one each with the Massachusetts Institute of Technology, Ohio University, and Princeton University. Completed works, status reports, and annotated bibliographies are presented for research topics, which include navigation, guidance, and control theory and practice, aircraft performance, human factors and air traffic management. An overview of the year's activities for each university is also presented.

  5. FAA/NASA Joint University Program for Air Transportation Research: 1993-1994

    NASA Technical Reports Server (NTRS)

    Hueschen, Richard M. (Compiler)

    1995-01-01

    This report summarizes the research conducted during the academic year 1993-1994 under the NASA/FAA sponsored Joint University Program for Air Transportation Research. The year end review was held at Ohio University, Athens, Ohio, July 14-15, 1994. The Joint University Program is a coordinated set of three grants sponsored by NASA Langley Research Center and the Federal Aviation Administration, one each with the Massachusetts Institute of Technology (NGL-22-009-640), Ohio University (NGR-36-009-017), and Princeton University (NGL-31-001-252). Completed works, status reports, and annotated bibliographies are presented for research topics which include navigation, guidance and control theory and practice, aircraft performance, human factors, and expert systems concepts applied to aircraft and airport operations. An overview of the year's activities for each university is also presented.

  6. 76 FR 54928 - Export Administration Regulations: Netherlands Antilles, Curaçao, Sint Maarten and Timor-Leste

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... Administration Regulations (EAR), e.g., the Commerce Country Chart, the Country Groups, and License Exception APP... Services, Bureau of Industry and Security, U.S. Department of Commerce at 202-482-2440 or by e-mail... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF...

  7. Additional safeguards for children in clinical investigations of food and drug administration-regulated products. Final rule.

    PubMed

    2013-02-26

    The Food and Drug Administration (FDA) is amending its regulations to provide additional safeguards for children enrolled in clinical investigations of FDA-regulated products. This rule finalizes the interim rule published in 2001 to bring FDA regulations into compliance with provisions of the Children's Health Act of 2000 (the Children's Health Act). The Children's Health Act requires that all research involving children that is conducted, supported, or regulated by the Department of Health and Human Services (HHS) be in compliance with HHS regulations providing additional protections for children involved as subjects in research. FDA is taking this action both to comply with the congressional mandate and because of increases in the enrollment of children in clinical investigations as a result of ongoing pediatric initiatives.

  8. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Administrative Provisions A Appendix A to Subpart A of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION... Good Manufacturing Practices Pt. 26, Subpt. A, App. A Appendix A to Subpart A of Part 26—List of... and veterinary use and establishing a European Agency for the Evaluation of Medicinal...

  9. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Administrative Provisions A Appendix A to Subpart A of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION... Good Manufacturing Practices Pt. 26, Subpt. A, App. A Appendix A to Subpart A of Part 26—List of... and veterinary use and establishing a European Agency for the Evaluation of Medicinal...

  10. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Administrative Provisions A Appendix A to Subpart A of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION... Good Manufacturing Practices Pt. 26, Subpt. A, App. A Appendix A to Subpart A of Part 26—List of... and veterinary use and establishing a European Agency for the Evaluation of Medicinal...

  11. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Administrative Provisions A Appendix A to Subpart A of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION... Good Manufacturing Practices Pt. 26, Subpt. A, App. A Appendix A to Subpart A of Part 26—List of... and veterinary use and establishing a European Agency for the Evaluation of Medicinal...

  12. 21 CFR Appendix A to Subpart A of... - List of Applicable Laws, Regulations, and Administrative Provisions

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Administrative Provisions A Appendix A to Subpart A of Part 26 Food and Drugs FOOD AND DRUG ADMINISTRATION... Good Manufacturing Practices Pt. 26, Subpt. A, App. A Appendix A to Subpart A of Part 26—List of... and veterinary use and establishing a European Agency for the Evaluation of Medicinal...

  13. 76 FR 78010 - General Services Administration Acquisition Regulation; Information Collection; Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-15

    ... Administration, Quality Assurance (GSAR Parts 542 and 546; GSA Form 1678 and GSA Form 308) AGENCY: Office of the... quality assurance. Public comments are particularly invited on: Whether this collection of information is... comments identified by Information Collection 3090- 0027, Contract Administration and Quality...

  14. 77 FR 18818 - General Services Administration Acquisition Regulation; Submission for OMB Review; Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... Administration, Quality Assurance (GSAR Parts 542 and 546; GSA Form 1678 and GSA Form 308) AGENCY: Office of the... quality assurance. A notice was published in the Federal Register at 76 FR 78010, on December 15, 2011. No... ``Information Collection 3090-0027, Contract Administration and Quality Assurance (GSAM Part 542 and Part...

  15. 39 CFR 233.9 - Regulations governing remission or mitigation of administrative, civil, and criminal forfeitures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... administrative, civil, and criminal forfeitures. 233.9 Section 233.9 Postal Service UNITED STATES POSTAL SERVICE... mitigation of administrative, civil, and criminal forfeitures. (a) Purpose, authority, and scope—(1) Purpose... under the supervision of the Chief Counsel. (3) Scope. This section governs any petition for...

  16. Use of Ground Penetrating Radar at the FAA's National Airport Pavement Test Facility

    NASA Astrophysics Data System (ADS)

    Injun, Song

    2015-04-01

    The Federal Aviation Administration (FAA) in the United States has used a ground-coupled Ground Penetrating Radar (GPR) at the National Airport Pavement Test Facility (NAPTF) since 2005. One of the primary objectives of the testing at the facility is to provide full-scale pavement response and failure information for use in airplane landing gear design and configuration studies. During the traffic testing at the facility, a GSSI GPR system was used to develop new procedures for monitoring Hot Mix Asphalt (HMA) pavement density changes that is directly related to pavement failure. After reviewing current setups for data acquisition software and procedures for identifying different pavement layers, dielectric constant and pavement thickness were selected as dominant parameters controlling HMA properties provided by GPR. A new methodology showing HMA density changes in terms of dielectric constant variations, called dielectric sweep test, was developed and applied in full-scale pavement test. The dielectric constant changes were successfully monitored with increasing airplane traffic numbers. The changes were compared to pavement performance data (permanent deformation). The measured dielectric constants based on the known HMA thicknesses were also compared with computed dielectric constants using an equation from ASTM D4748-98 Standard Test Method for Determining the Thickness of Bound Pavement Layers Using Short-Pulse Radar. Six inches diameter cylindrical cores were taken after construction and traffic testing for the HMA layer bulk specific gravity. The measured bulk specific gravity was also compared to monitor HMA density changes caused by aircraft traffic conditions. Additionally this presentation will review the applications of the FAA's ground-coupled GPR on embedded rebar identification in concrete pavement, sewer pipes in soil, and gage identifications in 3D plots.

  17. To Set Up Norms for Drug Safety and Inspection: To Guarantee Administrative Sufficiency and Avoid Regulators from Being Wrongly Punished.

    PubMed

    Xuan, Qingsheng; Dong, Zuojun; Shao, Mingli

    2015-09-01

    Currently, as there is no systematic norm or standard for drug safety and inspection, it cannot be judged whether the regulatory authority or regulators have fulfilled their administrative responsibilities entirely or not, when a drug safety-related incident occurs. And there is a probability that some may even be wrongly punished. In this study, we have analyzed the risk of not having appropriate norms in place and also put forward recommendations for the government or the regulatory authorities to set up norms to be fulfilled for drug safety and inspection issues. This, on one hand, could provide a basic guideline for the regulatory authorities and regulators to improve their professional levels and administrative acumen and on the other hand, it could also provide a baseline for society to judge whether the regulatory authorities and regulators have fulfilled their responsibilities correctly and thereby also help prevent regulators from being mistakenly punished. This study proposes that a systematic and functional norm for drug safety and inspection could be set up relating to the determination of the responsibilities of regulatory authorities and scope of various inspections, number and frequency of inspections, number and qualifications of regulators, handling of inspection results, inspection records, and disciplinary codes for inspectors. This study also puts forward suggestions on who should be responsible for drafting the norms and what are the factors that need to be considered while formulating the norms.

  18. Impact of implementing an Internal Bed Regulation Committee on administrative and care indicators at a teaching hospital

    PubMed Central

    Rodrigues, Luciane Cristine Ribeiro; Juliani, Carmen Maria Casquel Monti

    2015-01-01

    Objective To compare hospital indicators before and after implementing an Internal Bed Regulation Committee at a reference hospital. Methods It is an quantitative, evaluation, exploratory, descriptive and cross-sectional research. The data was gathered from the hospital administrative reports for the period 2008-2013, provided by the Information Technology Center of the Complexo FAMEMA. Results The indicators improved after implementation of the Internal Bed Regulation Committee. Conclusion The individuals involved in the process acknowledged the improvement. It is necessary to carry on the regulatory actions, especially in a comprehensive and complex healthcare system, such as the brazilian Sistema Único de Saúde. PMID:25993075

  19. Federal Aviation Administration retained savings program proposal

    SciTech Connect

    Hostick, D.J.; Larson, L.L.; Hostick, C.J.

    1998-03-01

    Federal legislation allows federal agencies to retain up to 50% of the savings associated with implementing energy efficiency and water conservation measures and practices. Given budget pressures to reduce expenditures, the use of retained savings to fund additional projects represents a source of funds outside of the traditional budget cycle. The Southwest Region Federal Aviation Administration (FAA) has tasked Pacific Northwest National Laboratory (PNNL) to develop a model retained savings program for Southwest Region FAA use and as a prototype for consideration by the FAA. PNNL recommends the following steps be taken in developing a Southwest Region FAA retained savings program: Establish a retained savings mechanism. Determine the level at which the retained savings should be consolidated into a fund. The preliminary recommendation is to establish a revolving efficiency loan fund at the regional level. Such a mechanism allows some consolidation of savings to fund larger projects, while maintaining a sense of facility ownership in that the funds will remain within the region.

  20. FAA center for aviation systems reliability: an overview

    NASA Astrophysics Data System (ADS)

    Brasche, Lisa J. H.

    1996-11-01

    The FAA Center for Aviation Systems Reliability has as its objectives: to develop quantitative nondestructive evaluation (NDE) methods for aircraft structures and materials, including prototype instrumentation, software, techniques and procedures; and to develop and maintain comprehensive education and training programs specific to the inspection of aviation structures. The program, which includes contributions from Iowa State University, Northwestern University, Wayne State University, Tuskegee University, AlliedSignal Propulsion Engines, General Electric Aircraft Engines and Pratt and Whitney, has been in existence since 1990. Efforts under way include: development of inspection for adhesively bonded structures; detection of corrosion; development of advanced NDE concepts that form the basis for an inspection simulator; improvements of titanium inspection as part of the Engine Titanium Consortium; development of education and training program. An overview of the efforts underway will be provided with focus on those technologies closest to technology transfer.

  1. NASA/FAA general aviation crash dynamics program - An update

    NASA Technical Reports Server (NTRS)

    Hayduk, R. J.; Thomson, R. G.; Carden, H. D.

    1979-01-01

    Work in progress in the NASA/FAA General Aviation Crash Dynamics Program for the development of technology for increased crash-worthiness and occupant survivability of general aviation aircraft is presented. Full-scale crash testing facilities and procedures are outlined, and a chronological summary of full-scale tests conducted and planned is presented. The Plastic and Large Deflection Analysis of Nonlinear Structures and Modified Seat Occupant Model for Light Aircraft computer programs which form part of the effort to predict nonlinear geometric and material behavior of sheet-stringer aircraft structures subjected to large deformations are described, and excellent agreement between simulations and experiments is noted. The development of structural concepts to attenuate the load transmitted to the passenger through the seats and subfloor structure is discussed, and an apparatus built to test emergency locator transmitters in a realistic environment is presented.

  2. Potassium determinations using SEM, FAAS and XRF: some experimental notes

    NASA Astrophysics Data System (ADS)

    Liritzis, I.; Mavrikis, D.; Zacharias, N.; Sakalis, A.; Tsirliganis, N.; Polymeris, G.S.

    The calibration of Scanning Electron Microscopy coupled with Energy Dispersive X- Rays Spec-trometry (SEM-EDS) for elemental quantitative analysis is an important task for characterization, provenance and absolute dating purposes. In particular the potassium determination is an im-portant contributor to dose rate assessments in luminescence and Electron Spin Resonance (ESR) dating. Here a SEM-EDX is calibrated on different archaeological and geoarchaeological materials against standard laboratory samples as well as measured by micro X-Rays Fluorescence (μXRF) and flame atomic absorption spectroscopy (FAAS) techniques. A common linear relationship is obtained for most elements and certain rock types used and two clear linear regressions for two types of rocks; one for granite, diorite, microgranite and sediments and another ceramic sherds, soils, marble schists, breccia. Such linear regressions become readily available for a future fast, efficient and accu-rate way of potassium determination.

  3. FAA Integrated Noise Model User’s Guide,

    DTIC Science & Technology

    1976-03-01

    lcsl kiport Docum .ntatioo Pog. 3 . R.cipi .nt e Catalog No. c2.~ FAA~~~~~~~ 2 J j 2. Gov .rn m.n~ Acc .,sie n No. @~ ~~~~~~~~~~~~ pg,.4 T tI. and...2.4 Flight Track Definitions 2— 3 2.5 Total Traffic Mix 2—14 2.6 Traffic Mix Allocation 2—18 2.7 User Options 2—19 3 . ALTERNATE NOISE DATA 3 —1 3.1...Background 3 —1 3.2 Specifying Alternate Noise Library Entries 3 —1 3.2.1 Library Identification 3 —2 3.2 .2 ProfIle Data 3 —2 3.2.3 Acoustic Data 3 —7 4

  4. 76 FR 8892 - Removal of Expired Federal Aviation Administration Regulations and References

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-16

    ... and are not currently in effect. This technical amendment is necessary to update our regulations. The... passed. To maintain an accurate body of regulations, we are removing and/or amending SFAR Nos. 36, 80, 92... recordkeeping requirements. 14 CFR Part 61 Aircraft, Airmen, Alcohol abuse, Aviation safety, Drug...

  5. 75 FR 12809 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... Federal Aviation Administration Notice of Intent To Rule on Request To Release Airport Property at the Dallas/Fort Worth International Airport, DFW Airport, Texas AGENCY: Federal Aviation Administration (FAA... provisions of Section 125 of the Wendell H. Ford Aviation Investment Reform Act for the 21st Century (AIR...

  6. The institutionalization of pharmaceutical administration after the korean liberation: focusing on regulating the pharmaceutical affairs law(yaksabeop) in 1953.

    PubMed

    Sihn, Kyu-Hwan

    2013-12-01

    The pharmaceutical administration under U.S Military Government in Korea and government of the Republic of Korea aimed at cleaning up the vestiges of Japanese imperialism which the pharmaceutical administration attached police administration and preparing with legal and systemic basis after the Korean liberation. The pharmaceutical bureau under U.S Military Government in Korea was reorganized as the independent division. The pharmaceutical bureau focused on preserving order, narcotics control and the distribution of relief drug. U.S Military Government proceeded supply side pharmaceutical policy for the distribution of relief drug without constructing human and material infrastructure. After the Korean War, Korean society asked the construction of system for nation building. Korean national assembly regulated National Medical Law(Gukmin uiryobeop) for promotion of public health in 1951. The Pharmaceutical Affairs Law(Yaksabeop) was regulated in 1953, and it prescribed the job requirement of pharmacist, apothecary, and drug maker and seller, and presented the frame of managing medical supplies. The Pharmaceutical Law originally planned the ideal pharmaceutical administration, but it rather secured the status of traditional apothecary, and drug maker and seller. On the contrary, though the Pharmaceutical Law guaranteed the traditional druggists, it did not materialize reproduction system such as educational and license system. It means that the traditional druggists would be degenerated in the near future. After the armistice agreement in 1953, Korean was in medical difficulties. Korean government was suffered from the deficiency of medical resources. Because of destruction of pharmaceutical facilities, Korean had to depend on United States and international aid. The Pharmaceutical Affairs Law did not cleaned up the vestiges of Japanese imperialism, and compromised with reality lacked human and material infrastructure. As a result, the law became the origin of

  7. 77 FR 58380 - General Services Administration Acquisition Regulation; Submission for OMB Review; Price...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... Reductions Clause AGENCY: Office of Acquisition Policy, General Services Administration (GSA). ACTION: Notice... collection requirement regarding the GSAR Price Reductions Clause. A notice was published in the Federal... identified by Information Collection 3090- 0235, Price Reduction Clause, by any of the following...

  8. 77 FR 8886 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... of public workshop. SUMMARY: The Food and Drug Administration (FDA) Detroit District Office, in co... District Office, 300 River Pl., Suite 5900, Detroit, MI 48207, 313-393-8143, Fax: 313- 393-8139, email... 13.3 Continuing Education Credits for SoCRA CE and Nurse CNE. SoCRA designates this live activity...

  9. 76 FR 78933 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    .... ACTION: Notice of public workshop. The Food and Drug Administration (FDA), Los Angeles District Office... continuing nurse education (CNE). SOCRA designates this educational activity for a maximum of 13.3 American.... SoCRA is an approved provider of CNE by the Pennsylvania State Nurses Association (PSNA),...

  10. 76 FR 51040 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    .... ACTION: Notice of public workshop. The Food and Drug Administration (FDA) Philadelphia District Office..., Philadelphia District, 900 U.S. Customhouse, Second & Chestnut Streets, Philadelphia, PA 19106, 215-597-4390... Continuing Education Credits for SoCRA CE and Nurse CNE. SOCRA designates this live activity for a maximum...

  11. 76 FR 17138 - Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    .... ACTION: Notice of public workshop. The Food and Drug Administration (FDA) Denver District Office, in co... activity for a maximum of 13.3 Continuing Education (CE) Credits for SoCRA CE and Nurse CNE. SoCRA... nursing education by the Pennsylvania State Nurses Association (PSNA), an accredited approver by...

  12. Extinction Training Regulates Neuroadaptive Responses to Withdrawal from Chronic Cocaine Self-Administration

    ERIC Educational Resources Information Center

    Smagula, Cynthia S.; Self, David W.; Choi, Kwang-Ho; Simmons, Diana; Walker, John R.

    2004-01-01

    Cocaine produces multiple neuroadaptations with chronic repeated use. Many of these neuroadaptations can be reversed or normalized by extinction training during withdrawal from chronic cocaine self-administration in rats. This article reviews our past and present studies on extinction-induced modulation of the neuroadaptive response to chronic…

  13. 76 FR 30842 - General Services Administration Acquisition Regulation; Rewrite of Part 570; Acquiring Leasehold...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... reference the size standard established by the Small Business Administration. Further revisions were made to include where the size standards may be found on the web. The definition of ``rent and related services...; 52.203-14, Display of Hotline Poster(s). GSAR 570.602 and 570.603 are renumbered as 570.702 and...

  14. 78 FR 31879 - General Services Administration Acquisition Regulation (GSAR); Electronic Contracting Initiative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES... Regulation (GSAR); Electronic Contracting Initiative (ECI) AGENCY: Office of Acquisition Policy, General... (Federal Supply Schedule) clause, and an Alternate I version of the clause that will require...

  15. 77 FR 25481 - General Services Administration Acquisition Regulation; Submission for OMB Review; Solicitation...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... without change to http://www.regulations.gov , including any personal and/or business confidential... measure success in meeting program objectives. As such, GSAR 516.506, Solicitation provision and...

  16. 77 FR 5020 - General Services Administration Acquisition Regulation; Information Collection; GSA Form 527...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... to http://www.regulations.gov , including any personal and/or business confidential information..., Contractor's Qualifications and Financial Information AGENCY: Office of the Chief Finance Officer, GSA... Financial Information. Public comments are particularly invited on: Whether this collection of...

  17. Isolation of a Saccharomyces cerevisiae long chain fatty acyl:CoA synthetase gene (FAA1) and assessment of its role in protein N- myristoylation

    PubMed Central

    1992-01-01

    Regulation of myristoylCoA pools in Saccharomyces cerevisiae plays an important role in modulating the activity of myristoylCoA:protein N- myristoyltransferase (NMT), an essential enzyme with an ordered Bi Bi reaction that catalyzes the transfer of myristate from myristoylCoA to greater than or equal to 12 cellular proteins. At least two pathways are available for generating myristoylCoA: de novo synthesis by the multifunctional, multisubunit fatty acid synthetase complex (FAS) and activation of exogenous myristate by acylCoA synthetase. The FAA1 (fatty acid activation) gene has been isolated by genetic complementation of a faal mutant. This single copy gene, which maps to the right arm of chromosome XV, specifies a long chain acylCoA synthetase of 700 amino acids. Analyses of strains containing NMT1 and a faal null mutation indicated that FAA1 is not essential for vegetative growth when an active de novo pathway for fatty acid synthesis is present. The role of FAA1 in cellular lipid metabolism and protein N-myristoylation was therefore assessed in strains subjected to biochemical or genetic blockade of FAS. At 36 degrees C, FAA1 is required for the utilization of exogenous myristate by NMT and for the synthesis of several phospholipid species. This requirement is not apparent at 24 or 30 degrees C, suggesting that S. cerevisiae contains another acylCoA synthetase activity whose chain length and/or temperature optima may differ from Faalp. PMID:1572893

  18. 77 FR 37523 - Proposed Revisions to the Export Administration Regulations: Implementation of Export Control...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ...President Obama directed the Administration in August 2009 to conduct a broad-based review of the U.S. export control system in order to identify additional ways to enhance national security. Then- Secretary of Defense Gates described in April 2010 the initial results of that effort and why fundamental reform of the U.S. export control system is necessary to enhance national security. Since......

  19. Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects.

    PubMed

    Chan, Jean L; Bullen, John; Lee, Jennifer H; Yiannakouris, Nikos; Mantzoros, Christos S

    2004-01-01

    Ghrelin, a stomach-derived orexigenic peptide, and leptin, a fat-derived anorexigenic hormone, act primarily in the hypothalamus to regulate energy homeostasis and have been reported to be regulated in opposite directions by acute and chronic changes in nutritional state. Nutritional, anthropometric, and hormonal predictors of circulating ghrelin have not yet been fully elucidated, and whether ghrelin is regulated by leptin in humans remains unknown. To address these questions, we performed cross-sectional and interventional studies. In 120 healthy men and women, ghrelin was negatively associated with leptin as well as overall and central adiposity, but not with total energy or specific macronutrient intake. The sexual dimorphism in ghrelin levels (higher levels in women than in men) and the negative correlation between ghrelin and insulin are largely mediated by central adiposity. In six lean men, complete fasting for 3 d resulted in a low leptin state without a major change in fat mass and abolished the meal-related secretory pattern of ghrelin without increasing 24-h ghrelin levels. In addition, recombinant human leptin administration in physiological and pharmacological doses did not regulate ghrelin over several hours to a few days. These data do not support a role for regulation of circulating ghrelin by leptin levels independently of changes in adiposity and suggest that the leptin and ghrelin systems for energy homeostasis function independently of each other in healthy humans.

  20. Effects of single cortisol administrations on human affect reviewed: Coping with stress through adaptive regulation of automatic cognitive processing.

    PubMed

    Putman, Peter; Roelofs, Karin

    2011-05-01

    The human stress hormone cortisol may facilitate effective coping after psychological stress. In apparent agreement, administration of cortisol has been demonstrated to reduce fear in response to stressors. For anxious patients with phobias or posttraumatic stress disorder this has been ascribed to hypothetical inhibition of retrieval of traumatic memories. However, such stress-protective effects may also work via adaptive regulation of early cognitive processing of threatening information from the environment. This paper selectively reviews the available literature on effects of single cortisol administrations on affect and early cognitive processing of affectively significant information. The concluded working hypothesis is that immediate effects of high concentration of cortisol may facilitate stress-coping via inhibition of automatic processing of goal-irrelevant threatening information and through increased automatic approach-avoidance responses in early emotional processing. Limitations in the existing literature and suggestions for future directions are briefly discussed.

  1. 77 FR 10665 - General Services Administration Acquisition Regulation; Acquisition-Related Thresholds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-23

    ... Acquisition Regulation (GSAR) to update the acquisition- related thresholds in two GSAR clauses. DATES...-related thresholds, the GSAR clause at 552.219-71, Notice to Offerors of Subcontracting Plan Requirements...'' and ``$1,500,000'', respectively. The GSAR clause at 552.219-72, Preparation, Submission,...

  2. Administrative Action to End Discrimination Based on Handicap: HEW's Section 504 Regulation.

    ERIC Educational Resources Information Center

    Engebretson, Mark F.

    1979-01-01

    Examines the drafting of regulations under Section 504 of the Rehabilitation Act of 1973, which prohibits discrimination against handicapped persons by recipients of federal funds. Available from Harvard Legislative Research Bureau, Langdell Hall, Harvard Law School, Cambridge, MA 02138; single copy $4.00. (Author/IRT)

  3. 77 FR 2726 - General Services Administration Acquisition Regulation; Information Collection; Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ... Final Payment (GSAR Part 532 and 552.232-72; GSA Form 1142 Release of Claims) AGENCY: Office of the... extension of a previously approved information collection requirement and the reinstatement of GSA Form 1142... 1142 was inadvertently deleted as part of the rewrite of GSAR regulations on Contract Financing....

  4. 77 FR 26763 - General Services Administration Acquisition Regulation; Submission for OMB Review; Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... Financing Final Payment (GSAR Parts 532 and 552.232-72; GSA Form 1142 Release of Claims) AGENCY: Office of... reinstatement of GSA Form 1142, Release of Claims, regarding final payment under construction and building services contract. GSA Form 1142 was inadvertently deleted as part of the rewrite of GSAR regulations...

  5. 76 FR 28855 - Defense Federal Acquisition Regulation Supplement; Business Systems-Definition and Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    .... Contractor business systems and internal controls are the first line of defense against waste, fraud, and... business systems are material terms, performance of which is required to ensure contracts will be performed..., 234, 242 et al. Defense Federal Acquisition Regulation Supplement; Business Systems-- Definition...

  6. 76 FR 20901 - Further Amendments to General Regulations of the Food and Drug Administration To Incorporate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ..., Drug, and Cosmetic Act (the FD&C Act) and providing FDA with the authority to regulate tobacco products... 21 CFR Part 1 Cosmetics, Drugs, Exports, Food labeling, Imports, Labeling, Reporting and... the Federal Food, Drug, and Cosmetic Act and under authority delegated to the Commissioner of Food...

  7. Guidelines for Federal Aviation Administration Regional Aviation Education Coordinators and Aviation Education Facilitators.

    ERIC Educational Resources Information Center

    Strickler, Mervin K., Jr.

    This publication is designed to provide both policy guidance and examples of how to work with various constituencies in planning and carrying out appropriate Federal Aviation Administration (FAA) aviation education activities. Information is provided on the history of aerospace/aviation education, FAA educational materials, aerospace/aviation…

  8. Fracture Analysis of the FAA/NASA Wide Stiffened Panels

    NASA Technical Reports Server (NTRS)

    Seshadri, B. R.; Newman, J. C., Jr.; Dawicke, D. S.; Young, R. D.

    1998-01-01

    This paper presents the fracture analyses conducted on the FAA/NASA stiffened and unstiffened panels using the STAGS (STructural Analysis of General Shells) code with the critical crack-tip-opening angle (CTOA) fracture criterion. The STAGS code with the "plane-strain" core option was used in all analyses. Previous analyses of wide, flat panels have shown that the high-constraint conditions around a crack front, like plane strain, has to be modeled in order for the critical CTOA fracture criterion to predict wide panel failures from small laboratory tests. In the present study, the critical CTOA value was determined from a wide (unstiffened) panel with anti-buckling guides. The plane-strain core size was estimated from previous fracture analyses and was equal to about the sheet thickness. Rivet flexibility and stiffener failure was based on methods and criteria, like that currently used in industry. STAGS and the CTOA criterion were used to predict load-against-crack extension for the wide panels with a single crack and multiple-site damage cracking at many adjacent rivet holes. Analyses were able to predict stable crack growth and residual strength with a few percent (5%) of stiffened panel tests results but over predicted the buckling failure load on a unstiffened panel with a single crack by 10%.

  9. Controlled impact demonstration seat/cabin restraint systems: FAA

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1986-01-01

    The FAA restraint system experiments consisted of 24 standard and modified seats, 2 standard galleys and 2 standard overhead compartments. Under the controlled impact demonstration (CID) program, the experimental objective was to demonstrate the effectiveness of individual restraint system designs when exposed to a survivable air-to-ground impact condition. What researchers were looking for was the performance exhibited by standard and modified designs, performance differences resulting from their installed cabin location, and interrelating performance demonstrated by test article and attaching floor and/or fuselage structure. The other restraint system experiment consisted of 2 standard overhead stowage compartments and 2 galley modules. Again, researchers were concerned with the retention of stowed equipment and carry-on articles. The overhead compartments were loaded with test weights up to their maximum capacity, and each of the galleys was filled with test articles: aft with normal galley equipment, forward with hazardous material test packages. A breakdown of instrumentation and distribution is given beginning with 11 instrumented type anthropomorphic dummies and 185 sensors which provided for acceleration and load measurements at the various experiment and associated structure locations. The onboard cameras provided additional coverage of these experiments, including the areas of cabin which were not instrumented. Test results showing the window-side leg forces versus pulse duration are given.

  10. An example of US Food and Drug Administration device regulation: medical devices indicated for use in acute ischemic stroke.

    PubMed

    Peña, Carlos; Li, Khan; Felten, Richard; Ogden, Neil; Melkerson, Mark

    2007-06-01

    The Food and Drug Administration has established requirements for protecting the public health by assuring the safety and effectiveness of a variety of medical products including drugs, devices, and biological products, and for promoting public health by expediting the approval of treatments that are safe and effective. The Center for Devices and Radiological Health is the center within the agency that is responsible for pre- and postmarket regulation of medical devices. In this article, we review current regulation of medical devices, research and development programs, pre- and postmarket perspectives, and future considerations of medical devices, particularly as they relate to devices targeting acute ischemic stroke as an example of the process. We also review the Center for Devices and Radiological Health's historical perspective of acute ischemic stroke trials and clinical trial design considerations used in prior studies that have led to US market clearance as they are related to currently marketed devices indicated for acute ischemic stroke.

  11. Increase in cocaine- and amphetamine-regulated transcript (CART) in specific areas of the mouse brain by acute caffeine administration.

    PubMed

    Cho, Jin Hee; Cho, Yun Ha; Kim, Hyo Young; Cha, Seung Ha; Ryu, Hyun; Jang, Wooyoung; Shin, Kyung Ho

    2015-04-01

    Caffeine produces a variety of behavioral effects including increased alertness, reduced food intake, anxiogenic effects, and dependence upon repeated exposure. Although many of the effects of caffeine are mediated by its ability to block adenosine receptors, it is possible that other neural substrates, such as cocaine- and amphetamine-regulated transcript (CART), may be involved in the effects of caffeine. Indeed, a recent study demonstrated that repeated caffeine administration increases CART in the mouse striatum. However, it is not clear whether acute caffeine administration alters CART in other areas of the brain. To explore this possibility, we investigated the dose- and time-dependent changes in CART immunoreactivity (CART-IR) after a single dose of caffeine in mice. We found that a high dose of caffeine (100 mg/kg) significantly increased CART-IR 2 h after administration in the nucleus accumbens shell (AcbSh), dorsal bed nucleus of the stria terminalis (dBNST), central nucleus of the amygdala (CeA), paraventricular hypothalamic nucleus (PVN), arcuate hypothalamic nucleus (Arc), and locus coeruleus (LC), and returned to control levels after 8 h. But this increase was not observed in other brain areas. In addition, caffeine administration at doses of 25 and 50 mg/kg appears to produce dose-dependent increases in CART-IR in these brain areas; however, the magnitude of increase in CART-IR observed at a dose of 50 mg/kg was similar or greater than that observed at a dose of 100 mg/kg. This result suggests that CART-IR in AcbSh, dBNST, CeA, PVN, Arc, and LC is selectively affected by caffeine administration.

  12. FAA (Federal Aviation Administration) Assessment of Satellite Concepts and Aviation Spectrum Requirements.

    DTIC Science & Technology

    1985-02-01

    will be available to all :-112,-S. t is also assumed that zhe sata iite navigation systcm, if GPS, will nave evolved aid imrprove(i to became toe pzime...1575.42 MHz; the total GPS system, with its dual frequency precision tanging capability, utilizes a total orf s,;hg,-y gt over 40 alz (+10.23 MALz centered

  13. Federal Aviation Administration (FAA) Reauthorization: An Overview of Legislative Action in the 111th Congress

    DTIC Science & Technology

    2010-03-30

    are substantially delayed, and it seeks an increase in funding for Essential Air Service (EAS) subsidies and small community air service grants. On...distributed either as formula grants or as discretionary grants. Small airports are much more dependent on AIP grants than large and medium hub airports...the AIP funding that is not distributed under the apportioned entitlements as well as the forgone PFC revenues that are not directed to the small

  14. Federal Aviation Administration (FAA) Reauthorization: An Overview of Legislative Action in the 111th Congress

    DTIC Science & Technology

    2010-03-22

    an increase in funding for Essential Air Service (EAS) subsidies and small community air service grants. On March 10, 2010, the Senate began...are distributed either as formula grants or as discretionary grants. Small airports are much more dependent on AIP grants than large and medium hub...directed to the small airport fund. Related PFC changes are discussed later in this report. Minimum Discretionary Fund 49 U.S.C. 47115 requires that

  15. FAA (Federal Aviation Administration) Aviation Forecasts - Fiscal Years 1984-1995,

    DTIC Science & Technology

    1984-02-01

    available to the public Taxi, Aviation Activity Forecasts, through the National Technical Comuters, Federal Aviation Administra- Information Service , tion...statutory mission, that being " service to the Nation by providing a safe and efficient aviation system which contributes to national security and the...proved insufficient to justify regularly scheduled service . Airline deregulation has accelerated this process with the Majors and Nationals concentrating

  16. FAA (Federal Aviation Administration) Aviation Forecasts, Fiscal Years 1990-2001

    DTIC Science & Technology

    1990-03-01

    Chico, CA (CIC) San Luis Obispo, CA (SBP) Chino, CA (CNO) Santa Ana, CA (SNA) Concord, CA (CCR) Santa Barbara, CA (SBA) El Monte, CA (EMT) Santa Maria ...San Juan International, PR (SJU) San Antonio Stinson, TX (SSF) San Juan Isla Grande, PR (SIG) Tomball D. W. Hooks, TX (DWH) Kwajalein AAF, WK (KWA

  17. Index to FAA (Federal Aviation Administration) Office of Aviation Medicine Reports: 1961 through 1982,

    DTIC Science & Technology

    1983-01-01

    high: The aeromedical aspects of marihuana . AD775889 73-13 Tobias, J. V., and Irons, F. M.: Reception of distorted speech. AD777564 73-14 Thackray, R. I...Steen, J. A.: Interaction between marihuana and altitude on a complex behavioral task in baboons. ADA020680/5GI 75-7 Melton, C. E., Jr., Smith, R. C...68-16, 69-2, 78-31, 80-4. hangover effects, 79-7, 79-26. Altitude and heat on performance, 71-17. and marihuana effects on performance, 75-6. chamber

  18. FAA Forecast Conference Proceedings (6th) Held at Washington, DC on 21 October 1980.

    DTIC Science & Technology

    1980-10-01

    specialized Oper.ratilonis miarkets, i nclur~d ing ra rt icuIa rly,, those that are to a high AN Year agro the FAA prolec -ted that 25) air r . ,rrier...JO Six Annual r 4 . ~FAA Forecast Conference -... Proceedings & u /]-/ " j, Oct8iLC Table of Contents ’.7 I L Part I: Introduction 2 Proceedings...lrowl Ii in FAA workload hig.Inaito ohsrg totti ihhghe o\\ er thle ne\\t 12 years. or)i thle o rder (it 3 piercent per pri( es and othe( r (osts. genieral

  19. Melatonin administration in diabetes: regulation of plasma Cr, V, and Mg in young male Zucker diabetic fatty rats.

    PubMed

    Navarro-Alarcon, Miguel; Ruiz-Ojeda, Francisco J; Blanca-Herrera, Rosa M; Kaki, Abdullah; Adem, Abdu; Agil, Ahmad

    2014-03-01

    The use of melatonin, a neurohormone present in plants, represents an exciting approach for the maintenance of optimum health conditions. Melatonin administration ameliorates glucose homeostasis in Zucker diabetic fatty (ZDF) rats. The objective of this study was to investigate the effects of melatonin in diabetes in relation to the levels and regulation of plasma chromium (Cr), vanadium (V), and magnesium (Mg) in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. At the age of 6 weeks, ZDF (n = 30) and ZL (n = 30) groups were each subdivided into three groups: control (C) (n = 10), vehicle-treated (V') (n = 10) and melatonin-treated (M) (10 mg kg(-1) per day; n = 10) groups for a 6 week period. After treatment, plasma mineral concentrations were measured by flame (Mg) and electrothermal (Cr and V) atomic absorption spectrometry. No significant differences were found between the C and V' groups (p > 0.05). Plasma Mg levels were significantly lower in C-ZDF vs. C-ZL rats, demonstrating the presence of hypomagnesemia in this diabetes mellitus model. Plasma V and Cr levels were significantly higher in M-ZDF vs. C-ZDF rats. Plasma Mg levels in ZDF rats were not affected by melatonin treatment (p > 0.05). Melatonin administration ameliorates the diabetic status of ZDF rats by enhancing plasma Cr and V concentrations. This appears to be the first report of a beneficial effect of melatonin treatment on plasma Cr and V regulation in ZDF rats.

  20. CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat.

    PubMed

    Krasnova, Irina N; Chiflikyan, Margarit; Justinova, Zuzana; McCoy, Michael T; Ladenheim, Bruce; Jayanthi, Subramaniam; Quintero, Cynthia; Brannock, Christie; Barnes, Chanel; Adair, Jordan E; Lehrmann, Elin; Kobeissy, Firas H; Gold, Mark S; Becker, Kevin G; Goldberg, Steven R; Cadet, Jean Lud

    2013-10-01

    Neuroplastic changes in the dorsal striatum participate in the transition from casual to habitual drug use and might play a critical role in the development of methamphetamine (METH) addiction. We examined the influence of METH self-administration on gene and protein expression that may form substrates for METH-induced neuronal plasticity in the dorsal striatum. Male Sprague-Dawley rats self-administered METH (0.1mg/kg/injection, i.v.) or received yoked saline infusions during eight 15-h sessions and were euthanized 2h, 24h, or 1month after cessation of METH exposure. Changes in gene and protein expression were assessed using microarray analysis, RT-PCR and Western blots. Chromatin immunoprecipitation (ChIP) followed by PCR was used to examine epigenetic regulation of METH-induced transcription. METH self-administration caused increases in mRNA expression of the transcription factors, c-fos and fosb, the neurotrophic factor, Bdnf, and the synaptic protein, synaptophysin (Syp) in the dorsal striatum. METH also caused changes in ΔFosB, BDNF and TrkB protein levels, with increases after 2 and 24h, but decreases after 1month of drug abstinence. Importantly, ChIP-PCR showed that METH self-administration caused enrichment of phosphorylated CREB (pCREB), but not of histone H3 trimethylated at lysine 4 (H3K4me3), on promoters of c-fos, fosb, Bdnf and Syp at 2h after cessation of drug intake. These findings show that METH-induced changes in gene expression are mediated, in part, by pCREB-dependent epigenetic phenomena. Thus, METH self-administration might trigger epigenetic changes that mediate alterations in expression of genes and proteins serving as substrates for addiction-related synaptic plasticity.

  1. Voglibose administration regulates body weight and energy intake in high fat-induced obese mice.

    PubMed

    Do, Hyun Ju; Jin, Taeon; Chung, Ji Hyung; Hwang, Ji Won; Shin, Min-Jeong

    2014-01-17

    We tested whether long-term administration of voglibose (VO) prevents diet induced obesity in addition to hypoglycemic effects in high fat fed mice and further investigated the underlying mechanisms by which voglibose exerts its weight lowering effect. Male C57BL/6 mice were fed ad libitum for 12 weeks with the control diet (CTL), high-fat diet (HFD) or the HFD with VO supplementations. Blood lipid profile, plasma leptin levels and hepatic triglyceride content, as well as expressions of genes involved in appetite and mitochondrial function were examined. The results showed that VO significantly reduced body weight, fat mass and energy intakes in high fat fed mice. VO showed improved metabolic profiles including blood glucose, triglyceride and free fatty acid. Elevated levels of plasma leptin in HFD were significantly reduced with the VO, furthermore, VO modulated the hypothalamic expressions of leptin receptors and appetite related genes. VO showed the upregulated expressions of PGC-1 in the liver and epididymal adipose tissue. In conclusion, VO may exert antiobesity properties through reductions in energy intake and improvement in mitochondrial function, indicating that VO has potential therapeutic use in patients with obesity, type 2 diabetes, and related complications.

  2. Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration.

    PubMed

    Smith, Laura N; Jedynak, Jakub P; Fontenot, Miles R; Hale, Carly F; Dietz, Karen C; Taniguchi, Makoto; Thomas, Feba S; Zirlin, Benjamin C; Birnbaum, Shari G; Huber, Kimberly M; Thomas, Mark J; Cowan, Christopher W

    2014-05-07

    Repeated cocaine exposure causes persistent, maladaptive alterations in brain and behavior, and hope for effective therapeutics lies in understanding these processes. We describe here an essential role for fragile X mental retardation protein (FMRP), an RNA-binding protein and regulator of dendritic protein synthesis, in cocaine conditioned place preference, behavioral sensitization, and motor stereotypy. Cocaine reward deficits in FMRP-deficient mice stem from elevated mGluR5 (or GRM5) function, similar to a subset of fragile X symptoms, and do not extend to natural reward. We find that FMRP functions in the adult nucleus accumbens (NAc), a critical addiction-related brain region, to mediate behavioral sensitization but not cocaine reward. FMRP-deficient mice also exhibit several abnormalities in NAc medium spiny neurons, including reduced presynaptic function and premature changes in dendritic morphology and glutamatergic neurotransmission following repeated cocaine treatment. Together, our findings reveal FMRP as a critical mediator of cocaine-induced behavioral and synaptic plasticity.

  3. Employee Retirement Income Security Act of 1974; rules and regulations for administration and enforcement; claims procedure. Final regulation; delay of applicability date.

    PubMed

    2001-07-09

    This action delays for at least six months and not more than one year the applicability date for the regulation governing minimum requirements for benefit claims procedures of group health plans covered by Title I of the Employee Retirement Income Security Act. As published on November 21, 2000, the benefit claims procedure would be applicable to claims filed on or after January 1, 2002. The current action amends the regulation so that it will apply to group health claims filed on or after the first day of the first plan year beginning on or after July 1, 2002, but in no event later than January 1, 2003. This action provides a limited additional period within which group health plan sponsors, administrators, and service providers can bring their claims processing systems into compliance with the new requirements. A postponement of the applicability date with respect to group health claims will allow a more orderly transition to the new standards and will avoid the confusion and additional expense that would be caused if certain pending Congressional bills are enacted before or soon after the original applicability date. This action does not apply to pension plans or plans providing disability or welfare benefits (other than group health). For these plans, the regulation will continue to be applicable to claims filed on or after January 1, 2002.

  4. 78 FR 6400 - Results of FAA Nitrous Oxide BLEVE Characterization Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... containing nitrous oxide stored under pressure above its normal boiling point. The FAA's Office of Commercial... commercial reusable launch vehicles. A potential hazard in nitrous oxide storage and handling is a...

  5. Systemic Administration of Induced Neural Stem Cells Regulates Complement Activation in Mouse Closed Head Injury Models

    PubMed Central

    Gao, Mou; Dong, Qin; Yao, Hui; Lu, Yingzhou; Ji, Xinchao; Zou, Mingming; Yang, Zhijun; Xu, Minhui; Xu, Ruxiang

    2017-01-01

    Complement activation plays important roles in the pathogenesis of central nervous system (CNS) diseases. Patients face neurological disorders due to the development of complement activation, which contributes to cell apoptosis, brain edema, blood-brain barrier dysfunction and inflammatory infiltration. We previously reported that induced neural stem cells (iNSCs) can promote neurological functional recovery in closed head injury (CHI) animals. Remarkably, we discovered that local iNSC grafts have the potential to modulate CNS inflammation post-CHI. In this study, we aimed to explore the role of systemically delivered iNSCs in complement activation following CNS injury. Our data showed that iNSC grafts decreased the levels of sera C3a and C5a and down-regulated the expression of C3d, C9, active Caspase-3 and Bax in the brain, kidney and lung tissues of CHI mice. Furthermore, iNSC grafts decreased the levels of C3d+/NeuN+, C5b-9+/NeuN+, C3d+/Map2+ and C5b-9+/Map2+ neurons in the injured cortices of CHI mice. Subsequently, we explored the mechanisms underlying these effects. With flow cytometry analysis, we observed a dramatic increase in complement receptor type 1-related protein y (Crry) expression in iNSCs after CHI mouse serum treatment. Moreover, both in vitro and in vivo loss-of-function studies revealed that iNSCs could modulate complement activation via Crry expression. PMID:28383046

  6. Complying with the Drug-Free Schools and Campuses Regulations: [EDGAR Part 86]. A Guide for University and College Administrators. Revised

    ERIC Educational Resources Information Center

    DeRicco, Beth

    2006-01-01

    This guide describes the requirements of the 1989 amendments to the "Drug-Free Schools and Communities Act" (DFSCA), as articulated in the "Education Department General Administrative Regulations" (EDGAR) Part 86,--the Drug-Free Schools and Campuses Regulations--and ways in which institutions of higher education (IHEs) have met…

  7. Restoring Equal Opportunity in Education: An Analysis of Arguments for and against the Bush Administration Single-Sex Education Regulations. Briefing Paper #C368

    ERIC Educational Resources Information Center

    English, Ashley

    2009-01-01

    In 2006, the George W. Bush Administration issued new Title IX regulations that allow for sex-segregated classrooms and schools in public, non-vocational elementary and secondary schools. These regulations provide schools with another condition that allows them to provide sex-segregated programs as long as they meet an "important governmental…

  8. Summary of the industry/NASA/FAA workshop on philosophy of automation: Promises and realities

    NASA Technical Reports Server (NTRS)

    Norman, Susan D.

    1990-01-01

    Issues of flight deck automation are multi-faceted and complex. The rapid introduction of advanced computer based technology on to the flight deck of transport category aircraft has had considerable impact on both aircraft operations and the flight crew. As part of NASA's responsibility to facilitate an active exchange of ideas and information between members of the aviation community, an Industry/NASA/FAA workshop was conducted in August 1988. One of the most important conclusions to emerge from the workshop was that the introduction of automation has clearly benefited aviation and has substantially improved the operational safety and efficiency of our air transport system. For example, one carrier stated that they have been flying the Boeing 767 (one of the first aircraft to employ substantial automation) since 1982, and they have never had an accident or incident resulting in damage to the aircraft. Notwithstanding its benefits, many issues associated with the design, certification, and operation of automated aircraft were identified. For example two key conceptual issues were the need for the crew to have a thorough understanding of the system and the importance of defining the pilot's role. With respect to certification, a fundamental issue is the lack of comprehensive human factors requirements in the current regulations. Operational considerations, which have been a factor in incidents involving automation, were also cited. Viewgraphs used in the presentation are given.

  9. Precision Departure Release Capability (PDRC): NASA to FAA Research Transition

    NASA Technical Reports Server (NTRS)

    Engelland, Shawn; Davis, Thomas J.

    2013-01-01

    departure runway assignments to the Center scheduling tool. The PDRC concept also incorporates earlier NASA and FAA research into automation-assisted CFR coordination. The PDRC concept reduces uncertainty by automatically communicating coordinated release times with seconds-level precision enabling TMCs and FLMs to work with target times rather than windows. NASA has developed a PDRC prototype system that integrates the Center's TMA system with a research prototype Tower decision support tool. A two-phase field evaluation was conducted at NASA's North Texas Research Station in Dallas-Fort Worth. The field evaluation validated the PDRC concept and demonstrated reduced release time uncertainty while being used for tactical departure scheduling of more than 230 operational flights over 29 weeks of operations.

  10. Up-regulation of hepatic receptor for growth hormone in the flounder ( Paralichthys olivaceus) after oral administration with exogenous GH

    NASA Astrophysics Data System (ADS)

    Liu, Zong-Zhu; Wang, Jin-Bao; Xu, Yong-Li; Wang, Yong; Zhang, Pei-Jun

    2001-06-01

    The iodination efficiency of salmon GH(sGH) was 38.82%, using a modification of the chloramine-T method. The specific activity of the125I-sGH was about 40 μCi/μg protein. The results of binding assay showed a single class of high affinity and low-capacity binding site in flounder liver. Long-term administration with exogenous GH can induce the up-regulation of hepatic GH receptor in total binding capacity though there was no significant difference in capacity of free binding sites of livers from control and experimental fish, this result also indicated that the liver from experimental fish, compared to that from control fish, had more occupied binding sites.

  11. An Investigation Into Criteria Commonly Used by the FAA to Grant Relief to Part 135 Operators Under FAR Sections: 135.213, 135.219, and/or 135.225

    NASA Technical Reports Server (NTRS)

    Williams, Louis J.; Heck, Michael L.; Burgess, Malcolm A.; Stough, H. P. (Technical Monitor)

    2002-01-01

    The objective of this study was to determine the criteria commonly used by the FAA to grant waivers, exemptions, or deviations to FAR Part 135, Sections 135.213, 135.219, and 135.225 and the potential impact on Flight Information Services Data Link (FISDL) implementation. These aviation regulations address the requirements for the use of weather reports or forecasts when conducting operations under FAR Part 135. In this study a literature search was conducted to obtain historical records of requests for relief from the 3 FAR sections under consideration. The exemption request records were then analyzed in order to determine the reasons given by the FAA for either granting or denying the request. In addition, FAA personnel and Part 135 operators were interviewed to determine the procedures used for satisfying the requirements of the 3 FAR sections.

  12. Survey: Federal Aviation Administration National Communication Center

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The National Communication (NATCOM) Center (commonly known as the FAA Weather Message Switching Center), is a Federal Aviation Administration (FAA) facility with responsibility for providing communication switching services to the National Weather Service (NWS), the FAA, commercial and private flight organizations under the auspices of the FAA, and DoD. Data handled by NATCOM include weather data, flight plans, and Notices to Airmen (NOTAMS) on both national and international networks. The communications and data management functions are handled through four computer-controlled communication networks designated as WMSC, AFTN, A-BDIS, and NASNET. The functions of these networks are discussed with emphasis on those networks that support the different elements of the NWS. The primary network of concern to NASA, the WMSC (Weather Message Switching Center) network, performs approximately 60 percent of its work for the NWS, 20 percent for the State Department, and 20 percent for the FAA. This document discusses the current and future systems capabilities and workload of NATCOM in terms of new roles.

  13. Differential regulation of MeCP2 and PP1 in passive or voluntary administration of cocaine or food.

    PubMed

    Bodetto, Sarah Pol; Romieu, Pascal; Sartori, Maxime; Tesone-Coelho, Carolina; Majchrzak, Monique; Barbelivien, Alexandra; Zwiller, Jean; Anglard, Patrick

    2014-12-01

    Cocaine exposure induces changes in the expression of numerous genes, in part through epigenetic modifications. We have initially shown that cocaine increases the expression of the chromatin remodeling protein methyl-CpG binding protein 2 (MeCP2) and characterized the protein phosphatase-1Cβ (PP1Cβ) gene, as repressed by passive i.p. cocaine injections through a Mecp2-mediated mechanism involving de novo DNA methylation. Both proteins being involved in learning and memory processes, we investigated whether voluntary cocaine administration would similarly affect their expression using an operant self-administration paradigm. Passive and voluntary i.v. cocaine intake was found to induce Mecp2 and to repress PP1Cβ in the prefrontal cortex and the caudate putamen. This observation is consistent with the role of Mecp2 acting as a transcriptional repressor of PP1Cβ and shows that passive intake was sufficient to alter their expression. Surprisingly, striking differences were observed under the same conditions in food-restricted rats tested for food pellet delivery. In the prefrontal cortex and throughout the striatum, both proteins were induced by food operant conditioning, but remained unaffected by passive food delivery. Although cocaine and food activate a common reward circuit, changes observed in the expression of other genes such as reelin and GAD67 provide new insights into molecular mechanisms differentiating neuroadaptations triggered by each reinforcer. The identification of hitherto unknown genes differentially regulated by drugs of abuse and a natural reinforcer should improve our understanding of how two rewarding stimuli differ in their ability to drive behavior.

  14. Regulations implementing the Federal Coal Mine Health and Safety Act of 1969, as amended. Employment Standards Administration, Labor. Final rule.

    PubMed

    2000-12-20

    On January 22, 1997, the Department issued a proposed rule to amend the regulations implementing the Black Lung Benefits Act. 62 FR 3338-3435 (Jan. 22, 1997). When the comment period closed on August 21, 1997, the Department had received written submissions from almost 200 interested persons, including coal miners, coal mine operators, insurers, physicians, and attorneys. The Department also held hearings in Charleston, West Virginia, and Washington, D.C. at which over 50 people testified. The Department carefully reviewed the testimony and the comments and, on October 8, 1999, issued a second notice of proposed rulemaking. 64 FR 54966-55072 (Oct. 8, 1999). In its second notice, the Department proposed changing several of the most important provisions in its initial proposal. The Department also explained its decision not to alter the original proposal with respect to other key regulations based on the comments received to date. Finally, the Department prepared an initial regulatory flexibility analysis. In order to ensure that small businesses that could be affected by the Department's proposal received appropriate notice of the Department's proposed changes, the Department mailed a copy of the second notice of proposed rulemaking to all coal mine operators contained in the databases maintained by the Mine Safety and Health Administration. The Department initially allowed interested parties until December 7, 1999 to file comments to its second proposal, but extended that period until January 6, 2000. The Department received 37 written submissions before the close of the comment period, from groups representing both coal miners and coal mine operators. The Department also received comments from individual miners, various coal mining and insurance companies, as well as from claims processing organizations, attorneys, and various professional organizations. The Department has carefully reviewed all of the comments, and is issuing its final rule. The rule contains a

  15. FAA Statistical Handbook of Aviation, Calendar Year 1992

    DTIC Science & Technology

    1992-01-01

    94-5 9. Performing Organization Name and Address 10. Work Unit No. (TRAIS) Federal Aviation Administration 800 Independence Avenue, S.W. 11. Contract...Total Change Change Change Total Change Cange Total Instrument 1962 45,658,593 1% 13,450,145 -1% 9,895,443 5% 18.172,317 +2 4,140,688 4% Operawon...Air Pacific Coast Aero Coach Ellis Air Taxi Pacific Island Air Alpha Empire Airways Pan Am Express Air Cape ERA Aviation Panorama Air Tours Air L. A

  16. FAA Airworthiness Assurance NDI Validation Center (AANC) operated by Sandia National Laboratories.

    SciTech Connect

    Roach, Dennis Patrick; Hartman, Roger D.

    2010-09-01

    Airworthiness Assurance NDI Validation Center (AANC) objectives are: (1) Enhance aircraft safety and reliability; (2) Aid developing advanced aircraft designs and maintenance techniques; (3) Provide our customers with comprehensive, independent, and quantitative/qualitative evaluations of new and enhanced inspection, maintenance, and repair techniques; (4) Facilitate transferring effective technologies into the aviation industry; (5) Support FAA rulemaking process by providing guidance on content & necessary tools to meet requirements or recommendations of FARs, ADs, ACs, SBs, SSIDs, CPCP, and WFD; and (6) Coordinate with and respond to Airworthiness Assurance Working Group (AAWG) in support of FAA Aviation Rulemaking Advisory Committee (ARAC).

  17. Administrator's Handbook for Elementary, Middle, Junior High and High Schools. Regulations and Criteria for Accrediting and Improving the Schools of Oklahoma. Bulletin No. 113-Y.

    ERIC Educational Resources Information Center

    Oklahoma State Dept. of Education, Oklahoma City. Div. of Instruction.

    This administrator handbook begins with statements summarizing Oklahoma's Division of Instruction and the guiding principles of education at the state's elementary and secondary levels. Following an outline of State Board of Education policies, the handbook lists various general regulations and progress criteria for the state as a whole.…

  18. Structural and molecular regulation of lung maturation by intratracheal vascular endothelial growth factor administration in the normally grown and placentally restricted fetus.

    PubMed

    McGillick, Erin V; Orgeig, Sandra; Morrison, Janna L

    2016-03-01

    Inhibition of hypoxia signalling leads to respiratory distress syndrome (RDS), whereas administration of vascular endothelial growth factor (VEGF), the most widely characterized hypoxia responsive factor, protects from RDS. In the lung of the chronically hypoxaemic placentally restricted (PR) fetus, there is altered regulation of hypoxia signalling. This leads to reduced surfactant maturation in late gestation and provides evidence for the increased risk of RDS in growth restricted neonates at birth. We evaluated the effect of recombinant human VEGF administration with respect to bypassing the endogenous regulation of hypoxia signalling in the lung of the normally grown and PR sheep fetus. There was no effect of VEGF administration on fetal blood pressure or fetal breathing movements. We examined the effect on the expression of genes regulating VEGF signalling (FLT1 and KDR), angiogenesis (ANGPT1, AQP1, ADM), alveolarization (MMP2, MMP9, TIMP1, COL1A1, ELN), proliferation (IGF1, IGF2, IGF1R, MKI67, PCNA), inflammation (CCL2, CCL4, IL1B, TNFA, TGFB1, IL10) and surfactant maturation (SFTP-A, SFTP-B, SFTP-C, SFTP-D, PCYT1A, LPCAT, LAMP3, ABCA3). Despite the effects of PR on the expression of genes regulating airway remodelling, inflammatory signalling and surfactant maturation, there were very few effects of VEGF administration on gene expression in the lung of both the normally grown and PR fetus. There were, however, positive effects of VEGF administration on percentage tissue, air space and numerical density of SFTP-B positive alveolar epithelial cells in fetal lung tissue. These results provide evidence for the stimulatory effects of VEGF administration on structural maturation in the lung of both the normally grown and PR fetus.

  19. The genomic organization of the Fanconi anemia group A (FAA) gene

    SciTech Connect

    Ianzano, L.; Centra, M.; Savino, M.

    1997-05-01

    Fanconi anemia (FA) is a genetically heterogeneous disease involving at least five genes on the basis of complementation analysis (FAA to FAE). The FAA gene has been recently isolated by two independent approaches, positional and functional cloning. In the present study we describe the genomic structure of the FAA gene. The gene contains 43 exons spanning approximately 80 kb as determined by the alignment of four cosmids and the fine localization of the first and the last exons in restriction fragments of these clones. Exons range from 34 to 188 bp. All but three of the splice sites were consistent with the ag-gt rule. We also describe three alternative splicing events in cDNA clones that result in the loss of exon 37, a 23-bp deletion at the 5{prime} end of exon 41. Sequence analysis of the 5{prime} region upstream of the putative transcription start site showed no obvious TATA and CAAT boxes, but did show a GC-rich region, typical of housekeeping genes. Knowledge of the structure of the FAA gene will provide an invaluable resource for the discovery of mutations in the gene that accounts for about 60-66% of FA patients. 24 refs., 3 figs., 1 tab.

  20. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 2

    SciTech Connect

    Soderquist, J.R.; Neri, L.M.; Bohon, H.L.

    1992-09-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing.

  1. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 1

    NASA Technical Reports Server (NTRS)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA conference on Fibrous Composites in structural Design. Presentations were made in the following areas of composite structural design: perspectives in composites; design methodology; design applications; design criteria; supporting technology; damage tolerance; and manufacturing.

  2. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 3

    NASA Technical Reports Server (NTRS)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing.

  3. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 2

    NASA Technical Reports Server (NTRS)

    Soderquist, Joseph R. (Compiler); Neri, Lawrence M. (Compiler); Bohon, Herman L. (Compiler)

    1992-01-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing.

  4. 14 CFR 193.9 - Will the FAA ever disclose information that is designated as protected under this part?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... is designated as protected under this part? 193.9 Section 193.9 Aeronautics and Space FEDERAL... protected under this part? The FAA discloses information that is designated as protected under this part when withholding it would not be consistent with the FAA's safety and security responsibilities,...

  5. NASA/FAA/NCAR Supercooled Large Droplet Icing Flight Research: Summary of Winter 1996-1997 Flight Operations

    NASA Technical Reports Server (NTRS)

    Miller, Dean; Ratvasky, Thomas; Bernstein, Ben; McDonough, Frank; Strapp, J. Walter

    1998-01-01

    During the winter of 1996-1997, a flight research program was conducted at the NASA-Lewis Research Center to study the characteristics of Supercooled Large Droplets (SLD) within the Great Lakes region. This flight program was a joint effort between the National Aeronautics and Space Administration (NASA), the National Center for Atmospheric Research (NCAR), and the Federal Aviation Administration (FAA). Based on weather forecasts and real-time in-flight guidance provided by NCAR, the NASA-Lewis Icing Research Aircraft was flown to locations where conditions were believed to be conducive to the formation of Supercooled Large Droplets aloft. Onboard instrumentation was then used to record meteorological, ice accretion, and aero-performance characteristics encountered during the flight. A total of 29 icing research flights were conducted, during which "conventional" small droplet icing, SLD, and mixed phase conditions were encountered aloft. This paper will describe how flight operations were conducted, provide an operational summary of the flights, present selected experimental results from one typical research flight, and conclude with practical "lessons learned" from this first year of operation.

  6. Superfund record of decision (EPA Region 2): FAA Technical Center, Atlantic County, Atlantic City International Airport, NJ. (Third remedial action), September 1992. Final report

    SciTech Connect

    Not Available

    1992-09-30

    The 5,000-acre FAA Technical Center site is located 8 miles northwest of Atlantic City, Atlantic Count, New Jersey, within the Atlantic Coastal Plain. In 1942, a Naval Air Base, including most of the existing runways, was constructed over two-thirds of the property. Interest in the property was transferred to the Federal Aviation Administration (FAA) in 1958 for use as research and development facilities and for the 1979 construction of the existing Technical/Administration Building. From 1978 to 1985, transformers containing PCB oil were stored on a 25- by 75-foot concrete pad, referred to as Area G, located at the lumber yard near building 125 in the western portion of the property. Some transformers are known to have leaked, contaminating the concrete pad and surrounding soil. During 1989, the entire concrete pad and contaminated soil were collected, excavated, and disposed of in an approved TSCA cell of a landfill. The ROD addresses principal threats to human health or the environment associated with PCB releases from the Area G transformer storage location. Based on the results of subsequent sampling, it is believed that Area G no longer poses a threat to human health or the environment.

  7. 75 FR 9142 - Regulations Under I.R.C. Section 7430 Relating to Awards of Administrative Costs and Attorneys...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... Awards of Administrative Costs and Attorneys Fees; Hearing Cancellation AGENCY: Internal Revenue Service... attorneys fees under section 7430 to conform to amendments made in the Taxpayer Relief Act of 1997 and...

  8. Extraction of nickel from edible oils with a complexing agent prior to determination by FAAS.

    PubMed

    Tokay, Feyzullah; Bağdat, Sema

    2016-04-15

    In the present work, a new extraction method for separation of nickel from edible oils and determination by FAAS is reported. This method is based on extraction of Ni(II) ions from the oil to aqueous phase with N,N'-bis(4-methoxysalicylidene) ethylenediamine (MSE) and determination by FAAS. Properties of the complex formed between MSE and Ni(II) were investigated spectrophotometrically. Central composite design (CCD) was utilized for optimization of MSE to oil, stirring time and temperature, which were 0.97 mL g(-1), 15.4 min, and 29.7°C, respectively. The developed method was tested with an oil-based metal standard and the recovery was 93.8±3.9%. The proposed method was applied with five different edible oils.

  9. Proceedings of the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. Volume 2

    NASA Technical Reports Server (NTRS)

    Bigelow, Catherine A. (Compiler)

    1997-01-01

    This publication contains the fifty-two technical papers presented at the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. The symposium, hosted by the FAA Center of Excellence for Computational Modeling of Aircraft Structures at Georgia Institute of Technology, was held to disseminate information on recent developments in advanced technologies to extend the life of high-time aircraft and design longer-life aircraft. Affiliations of the participants included 33% from government agencies and laboratories, 19% from academia, and 48% from industry; in all 240 people were in attendance. Technical papers were selected for presentation at the symposium, after a review of extended abstracts received by the Organizing Committee from a general call for papers.

  10. Proceedings of the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. Volume 1

    NASA Technical Reports Server (NTRS)

    Bigelow, Catherine A. (Compiler)

    1997-01-01

    This publication contains the fifty-two technical papers presented at the FAA-NASA Symposium on the Continued Airworthiness of Aircraft Structures. The symposium, hosted by the FAA Center of Excellence for Computational Modeling of Aircraft Structures at Georgia Institute of Technology, was held to disseminate information on recent developments in advanced technologies to extend the life of high-time aircraft and design longer-life aircraft. Affiliations of the participants included 33% from government agencies and laboratories, 19% from academia, and 48% from industry; in all 240 people were in attendance. Technical papers were selected for presentation at the symposium, after a review of extended abstracts received by the Organizing Committee from a general call for papers.

  11. Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design, volume 3

    SciTech Connect

    Soderquist, J.R.; Neri, L.M.; Bohon, H.L.

    1992-09-01

    This publication contains the proceedings of the Ninth DOD/NASA/FAA Conference on Fibrous Composites in Structural Design held at Lake Tahoe, Nevada, during 4-7 Nov. 1991. Presentations were made in the following areas of composite structural design: perspectives in composites, design methodology, design applications, design criteria, supporting technology, damage tolerance, and manufacturing. Separate abstracts have been prepared for articles from this report.

  12. NextGen Technologies on the FAA's Standard Terminal Automation Replacement System

    NASA Technical Reports Server (NTRS)

    Witzberger, Kevin; Swenson, Harry; Martin, Lynne; Lin, Melody; Cheng, Jinn-Hwei

    2014-01-01

    This paper describes the integration, evaluation, and results from a high-fidelity human-in-the-loop (HITL) simulation of key NASA Air Traffic Management Technology Demonstration - 1 (ATD- 1) technologies implemented in an enhanced version of the FAA's Standard Terminal Automation Replacement System (STARS) platform. These ATD-1 technologies include: (1) a NASA enhanced version of the FAA's Time-Based Flow Management, (2) a NASA ground-based automation technology known as controller-managed spacing (CMS), and (3) a NASA advanced avionics airborne technology known as flight-deck interval management (FIM). These ATD-1 technologies have been extensively tested in large-scale HITL simulations using general-purpose workstations to study air transportation technologies. These general purpose workstations perform multiple functions and are collectively referred to as the Multi-Aircraft Control System (MACS). Researchers at NASA Ames Research Center and Raytheon collaborated to augment the STARS platform by including CMS and FIM advisory tools to validate the feasibility of integrating these automation enhancements into the current FAA automation infrastructure. NASA Ames acquired three STARS terminal controller workstations, and then integrated the ATD-1 technologies. HITL simulations were conducted to evaluate the ATD-1 technologies when using the STARS platform. These results were compared with the results obtained when the ATD-1 technologies were tested in the MACS environment. Results collected from the numerical data show acceptably minor differences, and, together with the subjective controller questionnaires showing a trend towards preferring STARS, validate the ATD-1/STARS integration.

  13. 75 FR 1020 - Amendments to the Export Administration Regulations (EAR) Based Upon the Accession of Albania and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-08

    ... Regulations (EAR) Based Upon the Accession of Albania and Croatia to Formal Membership in the North Atlantic... * * * * * * * Albania \\2 3\\ X X ...... X ....... X X X X ...... ...... ...... ...... ...... * * * * * * * Croatia \\3\\...

  14. The individual mandate as healthcare regulation: what the Obama Administration should have said in NFIB v. Sebelius.

    PubMed

    Moncrieff, Abigail R

    2013-01-01

    There was an argument that the Obama Administration's lawyers could have made--but didn't--in defending Obamacare's individual mandate against constitutional attack. That argument would have highlighted the role of comprehensive health insurance in steering individuals' healthcare savings and consumption decisions. Because consumer-directed healthcare, which reaches its apex when individuals self-insure, suffers from several known market failures and because comprehensive health insurance policies play an unusually aggressive regulatory role in attempting to correct those failures, the individual mandate could be seen as an attempt to eliminate inefficiencies in the healthcare market that arise from individual decisions to self-insure. This argument would done a better job than the Obama Administration's of aligning the individual mandate with existing Commerce Clause and Necessary and Proper Clause precedent, and it would have done a better job of addressing the conservative Justices' primary concerns with upholding the mandate. This Article lays out this forgone defense of the individual mandate.

  15. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  16. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  17. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  18. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  19. 7 CFR 301.52-2 - Authorization for Deputy Administrator to list regulated areas and suppressive or generally...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE DOMESTIC QUARANTINE NOTICES Pink Bollworm Quarantine and Regulations § 301.52-2... States, territories, or districts, or portions thereof, in which pink bollworm has been found or in which there is reason to believe that pink bollworm is present, or which it is deemed necessary to...

  20. 77 FR 5387 - Amendment to the Export Administration Regulations: Addition of a Reference to a Provision of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... Regulations: Addition of a Reference to a Provision of the Iran Sanctions Act of 1996 (ISA) and Statement of... Iran Sanctions Act of 1996 (ISA), which states BIS's licensing policy for export and reexport... Amendment The Iran Sanctions Act of 1996 (50 U.S.C. 1701 note) (ISA) requires the President to...

  1. 14 CFR 406.109 - Administrative law judges-powers and limitations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Administrative law judges-powers and limitations. 406.109 Section 406.109 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.109 Administrative law...

  2. 14 CFR 406.109 - Administrative law judges-powers and limitations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Administrative law judges-powers and limitations. 406.109 Section 406.109 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.109 Administrative law...

  3. 14 CFR 406.109 - Administrative law judges-powers and limitations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Administrative law judges-powers and limitations. 406.109 Section 406.109 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.109 Administrative law...

  4. 14 CFR 406.109 - Administrative law judges-powers and limitations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Administrative law judges-powers and limitations. 406.109 Section 406.109 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.109 Administrative law...

  5. 14 CFR 406.109 - Administrative law judges-powers and limitations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Administrative law judges-powers and limitations. 406.109 Section 406.109 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.109 Administrative law...

  6. ARRA FEMP Technical Assistance -- Federal Aviation Administration Project 209 -- Control Tower and Support Building, Palm Springs, CA

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-03-31

    This report represents findings of a design review team that evaluated construction documents (at the 100% level) and operating specifications for a new control tower and support building that will be built in Palm Springs, California by the Federal Aviation Administration (FAA). The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for the FAA that would not have otherwise occurred.

  7. Simultaneous determination of iron and copper in children's sera by FAAS.

    PubMed

    Luterotti, Svjetlana; Kordić, Tončica Vukman; Dodig, Slavica

    2011-03-01

    A new and simple flame atomic-absorption spectrometric (FAAS) method is proposed for simultaneous determination of iron and copper in children's sera. It is based on single-step sample pretreatment (deproteinization with 3 mol L-1 HCl, ratio 1:1) and single-step calibration using 1.5 mol L-1 HCl standard. During method's optimization a short multifactorial design experiment was used. The proposed method assures accuracy, sensitivity and precision comparable to that of the reference methods. The new approach is simple and time-, labour- and serum-saving, the latter being especially important in pediatric diagnostics.

  8. Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in response to formoterol administration in rat skeletal muscle.

    PubMed

    Joassard, Olivier Roger; Amirouche, Adel; Gallot, Yann Simon; Desgeorges, Marine Maud; Castells, Josiane; Durieux, Anne-Cécile; Berthon, Phanélie; Freyssenet, Damien Gilles

    2013-11-01

    Administration of β2-agonists triggers skeletal muscle anabolism and hypertrophy. We investigated the time course of the molecular events responsible for rat skeletal muscle hypertrophy in response to 1, 3 and 10 days of formoterol administration (i.p. 2000μg/kg/day). A marked hypertrophy of rat tibialis anterior muscle culminated at day 10. Phosphorylation of Akt, ribosomal protein S6, 4E-BP1 and ERK1/2 was increased at day 3, but returned to control level at day 10. This could lead to a transient increase in protein translation and could explain previous studies that reported increase in protein synthesis following β2-agonist administration. Formoterol administration was also associated with a significant reduction in MAFbx/atrogin-1 mRNA level (day 3), suggesting that formoterol can also affect protein degradation of MAFbx/atrogin1 targeted substrates, including MyoD and eukaryotic initiation factor-3f (eIF3-f). Surprisingly, mRNA level of autophagy-related genes, light chain 3 beta (LC3b) and gamma-aminobutyric acid receptor-associated protein-like 1 (Gabarapl1), as well as lysosomal hydrolases, cathepsin B and cathepsin L, was significantly and transiently increased after 1 and/or 3 days, suggesting that autophagosome formation would be increased in response to formoterol administration. However, this has to be relativized since the mRNA level of Unc-51-like kinase1 (Ulk1), BCL2/adenovirus E1B interacting protein3 (Bnip3), and transcription factor EB (TFEB), as well as the protein content of Ulk1, Atg13, Atg5-Atg12 complex and p62/Sqstm1 remained unchanged or was even decreased in response to formoterol administration. These results demonstrate that the effects of formoterol are mediated, in part, through the activation of Akt-mTOR pathway and that other signaling pathways become more important in the regulation of skeletal muscle mass with chronic administration of β2-agonists.

  9. Differentiation and proliferation of periosteal osteoblast progenitors are differentially regulated by estrogens and intermittent parathyroid hormone administration.

    PubMed

    Ogita, Mami; Rached, Marie Therese; Dworakowski, Elzbieta; Bilezikian, John P; Kousteni, Stavroula

    2008-11-01

    The periosteum is now widely recognized as a homeostatic and therapeutic target for actions of sex steroids and intermittent PTH administration. The mechanisms by which estrogens suppress but PTH promotes periosteal expansion are not known. In this report, we show that intermittent PTH(1-34) promotes differentiation of periosteal osteoblast precursors as evidenced by the stimulation of the expression or activity of alkaline phosphatase as well as of targets of the bone morphogenetic protein 2 (BMP-2) and Wnt pathways. In contrast, 17beta-estradiol (E2) had no effect by itself. However, it attenuated PTH- or BMP-2-induced differentiation of primary periosteal osteoblast progenitors. Administration of intermittent PTH to ovariectomized mice induced rapid phosphorylation of the BMP-2 target Smad1/5/8 in the periosteum. A replacement dose of E2 had no effect by itself but suppressed PTH-induced phosphorylation of Smad1/5/8. In contrast to its effects to stimulate periosteal osteoblast differentiation, PTH promoted and subsequently suppressed proliferation of periosteal osteoblast progenitors in vitro and in vivo. E2 promoted proliferation and attenuated the antiproliferative effect of PTH. Both hormones protected periosteal osteoblasts from apoptosis induced by various proapoptotic agents. These observations suggest that the different effects of PTH and estrogens on the periosteum result from opposing actions on the recruitment of early periosteal osteoblast progenitors. Intermittent PTH promotes osteoblast differentiation from periosteum-derived mesenchymal progenitors through ERK-, BMP-, and Wnt-dependent signaling pathways. Estrogens promote proliferation of early osteoblast progenitors but inhibit their differentiation by osteogenic agents such as PTH or BMP-2.

  10. Sex differences in nicotine self-administration in rats during progressive unit dose reduction: Implications for nicotine regulation policy

    PubMed Central

    Grebenstein, Patricia; Burroughs, Danielle; Zhang, Yan; LeSage, Mark G.

    2013-01-01

    Reducing the nicotine content in tobacco products is being considered by the FDA as a policy to reduce the addictiveness of tobacco products. Understanding individual differences in response to nicotine reduction will be critical to developing safe and effective policy. Animal and human research demonstrating sex differences in the reinforcing effects of nicotine suggests that males and females may respond differently to nicotine-reduction policies. However, no studies have directly examined sex differences in the effects of nicotine unit-dose reduction on nicotine self-administration (NSA) in animals. The purpose of the present study was to examine this issue in a rodent self-administration model. Male and female rats were trained to self-administer nicotine (0.06 mg/kg) under an FR 3 schedule during daily 23 h sessions. Rats were then exposed to saline extinction and reacquisition of NSA, followed by weekly reductions in the unit dose (0.03 to 0.00025 mg/kg) until extinction levels of responding were achieved. Males and females were compared with respect to baseline levels of intake, resistance to extinction, degree of compensatory increases in responding during dose reduction, and the threshold reinforcing unit dose of nicotine. Exponential demand-curve analysis was also conducted to compare the sensitivity of males and females to increases in the unit price (FR/unit dose) of nicotine (i.e., elasticity of demand or reinforcing efficacy). Females exhibited significantly higher baseline intake and less compensation than males. However, there were no sex differences in the reinforcement threshold or elasticity of demand. Dose–response relationships were very well described by the exponential demand function (r2 values > 0.96 for individual subjects). These findings suggest that females may exhibit less compensatory smoking in response to nicotine reduction policies, even though their nicotine reinforcement threshold and elasticity of demand may not differ from

  11. The Federal Aviation Administration/Massachusetts Institute of Technology (FAA/MIT) Lincoln Laboratory Doppler weather radar program

    NASA Technical Reports Server (NTRS)

    Evans, James E.

    1988-01-01

    The program focuses on providing real-time information on hazardous aviation weather to end users such as air traffic control and pilots. Existing systems will soon be replaced by a Next Generation Weather Radar (NEXRAD), which will be concerned with detecting such hazards as heavy rain and hail, turbulence, low-altitude wind shear, and mesocyclones and tornadoes. Other systems in process are the Central Weather Processor (CWP), and the terminal Doppler weather radar (TDWR). Weather measurements near Memphis are central to ongoing work, especially in the area of microbursts and wind shear.

  12. Administrators: Nursing Home Administrator

    ERIC Educational Resources Information Center

    Kahl, Anne

    1976-01-01

    Responsibilities, skills needed, training needed, earnings, employment outlook, and sources of additional information are outlined for the administrator who holds the top management job in a nursing home. (JT)

  13. Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase β/ζ, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration

    PubMed Central

    Laorden, María Luisa; Milanés, María Victoria

    2016-01-01

    Background: Most classes of addictive substances alter the function and structural plasticity of the brain reward circuitry. Midkine (MK) and pleiotrophin (PTN) are growth/differentiation cytokines which, similarly to neurotrophins, play an important role in repair, neurite outgrowth, and cell differentiation. PTN or MK signaling through receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ), leads to the activation of extracellular signal-regulated kinases and thymoma viral proto-oncogene. This activation induces morphological changes and modulates addictive behaviors. Besides, there is increasing evidence that during the development of drug addiction, astrocytes contribute to the synaptic plasticity by synthesizing and releasing substances such as cytokines. Methods: In the present work we studied the effect of acute morphine administration, chronic morphine administration, and morphine withdrawal on PTN, MK, and RPTPβ/ζ expression and on their signaling pathways in the nucleus accumbens. Results: Present results indicated that PTN, MK, and RPTPβ/ζ levels increased after acute morphine injection, returned to basal levels during chronic opioid treatment, and were up-regulated again during morphine withdrawal. We also observed an activation of astrocytes after acute morphine injection and during opiate dependence and withdrawal. In addition, immunofluorescence analysis revealed that PTN, but not MK, was overexpressed in astrocytes and that dopaminoceptive neurons expressed RPTPβ/ζ. Conclusions: All these observations suggest that the neurotrophic and behavioral adaptations that occur during opiate addiction could be, at least partly, mediated by cytokines. PMID:26164717

  14. Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice

    PubMed Central

    Faccidomo, Sara; Salling, Michael C; Galunas, Christina; Hodge, Clyde W

    2015-01-01

    Rationale Extracellular-signal regulated protein kinase (ERK1/2) is activated by ethanol in reward-related brain regions. Accordingly, systemic inhibition of ERK1/2 potentiates ethanol reinforcement. However, the brain region(s) that mediate this effect are unknown. Objective To pharmacologically inhibit ERK1/2 in the medial prefrontal cortex (PFC), nucleus accumbens (NAC) and amygdala (AMY) prior to ethanol or sucrose self-administration, and evaluate effects of operant ethanol self-administration on ERK1/2 phosphorylation (pERK1/2). Methods Male C57BL/6J mice were trained to lever press on a fixed-ratio-4 schedule of 9% ethanol+2% sucrose (ethanol) or 2% sucrose (sucrose) reinforcement. Mice were sacrificed immediately after the 30th self-administration session and pERK1/2 immunoreactivity was quantified in targeted brain regions. Additional groups of mice were injected with SL 327 (0–1.7 μg/side) in PFC, NAC or AMY prior to self-administration. Results pERK1/2 immunoreactivity was significantly increased by operant ethanol (g/kg=1.21 g/kg; BAC=54.9 mg/dl) in the PFC, NAC (core and shell), and AMY (central nucleus) as compared to sucrose. Microinjection of SL 327 (1.7 μg) into the PFC selectively increased ethanol self-administration. Intra-NAC injection of SL 327 had no effect on ethanol- but suppressed sucrose-reinforced responding. Intra-AMY microinjection of SL 327 had no effect on either ethanol- or sucrose-reinforced responding. Locomotor activity was unaffected under all conditions. Conclusions Operant ethanol self-administration increases pERK1/2 activation in the PFC, NAC and AMY. However, ERK1/2 activity only in the PFC mechanistically regulates ethanol self-administration. These data suggest that ethanol-induced activation of ERK1/2 in the PFC is a critical pharmacological effect that mediates the reinforcing properties of the drug. PMID:26123321

  15. The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain.

    PubMed

    Miszkiel, Joanna; Detka, Jan; Cholewa, Joanna; Frankowska, Małgorzata; Nowak, Ewa; Budziszewska, Bogusława; Przegaliński, Edmund; Filip, Małgorzata

    2014-08-01

    According to a current hypothesis of learning processes, recent papers pointed out to an important role of the extracellular signal-regulated kinase (ERK), in drug addiction. We employed the Western blotting techniques to examine the ERK activity immediately after cocaine iv self-administration and in different drug-free withdrawal periods in rats. To distinguish motivational vs. pharmacological effects of the psychostimulant intake, a "yoked" procedure was used. Animals were decapitated after 14 daily cocaine self-administration sessions or on the 1st, 3rd or 10th extinction days. At each time point the activity of the ERK was assessed in several brain structures, including the prefrontal cortex, hippocampus, dorsal striatum and nucleus accumbens. Passive, repeated iv cocaine administration resulted in a 45% increase in ERK phosphorylation in the hippocampus while cocaine self-administration did not change brain ERK activity. On the 1st day of extinction, the activity of the ERK in the prefrontal cortex was decreased in rats with a history of cocaine chronic intake: by 66% for "active" cocaine group and by 35% for "yoked" cocaine group. On the 3rd day the reduction in the ERK activity (25-34%) was observed in the hippocampus for both cocaine-treated groups, and also in the nucleus accumbens for "yoked" cocaine group (40%). On the 10th day of extinction there was no significant alteration in ERK activity in any group of rats. Our findings suggest that cortical ERK is involved in cocaine seeking behavior in rats. They also indicate the time and regional adaptations in this enzyme activity after cocaine withdrawal.

  16. Determination of Ca, K, Mg and Fe in four fish species by FAAS

    NASA Astrophysics Data System (ADS)

    Cui, Xiaoli; Wang, Yijun; She, Xilin

    2010-09-01

    A method for determining calcium (Ca), potassium (K), magnesium (Mg) and iron (Fe) in four fish species was optimized and validated. It included microwave mineralization of the samples and subsequent quantification by flame atomic absorption spectroscopy (FAAS) with Zeeman-effect background correction. Using HNO3 (65%) and H2O2 (33%) as extraction solutions, the optimal conditions of extraction were established as follows: 0.5 g of sample mass; microwave time program of 300 W/5 min and 600 W/5 min. The method was free of matrix interferences. The linear correlation coefficients were ⩾0.9991, the recovery percentage of analytes was from 99.31% to 103.70% and the RSD (relative standard deviation) was lower than 2.06%. The detection limits obtained were 32.3, 43.2, 14.0 and 68.6 ng mL-1 for Ca, K, Mg and Fe in FAAS respectively. It is shown that the method is rapid, simple, sensitive and accurate. The method was applied to the studies of digestibility and measurement of these nutrients in samples of fish collected from Norway, Japan and China.

  17. Muscarinic receptor plasticity in the brain of senescent rats: down-regulation after repeated administration of diisopropyl fluorophosphate

    SciTech Connect

    Pintor, A.; Fortuna, S.; Volpe, M.T.; Michalek, H.

    1988-01-01

    Potential age-related differences in the response of Fischer 344 rats to subchronic treatment with diisopropylfluorophosphate (DFP) were evaluated in terms of brain cholinesterase (ChE) inhibition and muscarinic receptor sites. Male 3- and 24-month old rats were sc injected with sublethal doses of DFP for 2 weeks and killed 48 hrs after the last treatment. In the cerebral cortex, hippocampus and striatum of control rats a significant age-related reduction of ChE and of maximum number of /sup 3/H-QNB binding sites (Bmax) was observed. The administration of DFP to senescent rats resulted in more pronounced and longer lasting syndrome of cholinergic stimulation, with marked body weight loss and 60% mortality. The percentage inhibition of brain ChE induced by DFP did not differ between young and senescent rats. As expected, in young rats DFP caused a significant decrease of Bmax, which in the cerebral cortex reached about 40%. In the surviving senescent rats, the percentage decrease of Bmax due to DFP with respect to age-matched controls was very similar to that of young animals, especially in the cerebral cortex. Thus there is great variability in the response of aged rats to DFP treatment, from total failure of adaptive mechanisms resulting in death to considerable muscarinic receptor plasticity.

  18. Extended access to methamphetamine self-administration up-regulates dopamine transporter levels 72 hours after withdrawal in rats.

    PubMed

    D'Arcy, Christina; Luevano, Joe E; Miranda-Arango, Manuel; Pipkin, Joseph A; Jackson, Jonathan A; Castañeda, Eddie; Gosselink, Kristin L; O'Dell, Laura E

    2016-01-01

    Previous studies have demonstrated that there are persistent changes in dopamine systems following withdrawal from methamphetamine (METH). This study examined changes in striatal dopamine transporter (DAT), tyrosine hydroxylase (TH) and dopamine receptor 2 (D2) 72 h after withdrawal from METH intravenous self- administration (IVSA). Rats were given limited (1h) or extended (6h) access to METH IVSA (0.05 mg/kg/0.1 ml infusion) for 22 days. Controls did not receive METH IVSA. The rats given extended access to IVSA displayed higher METH intake during the first hour of drug access compared to rats given limited access. Extended access to METH also produced a concomitant increase in striatal DAT levels relative to drug-naïve controls. There were no changes in TH or D2 levels across groups. Previous studies have reported a decrease in striatal DAT levels during protracted periods (>7 days) of withdrawal from METH IVSA. This study extends previous work by showing an increase in striatal DAT protein expression during an earlier time point of withdrawal from this drug. These results are an important step toward understanding the dynamic changes in dopamine systems that occur during different time points of withdrawal from METH IVSA.

  19. Employee Retirement Income Security Act of 1974; rules and regulations for administration and enforcement; claims procedure--Department of Labor. Notice of proposed rulemaking.

    PubMed

    1998-09-09

    This document contains a proposed regulation revising the minimum requirements for benefit claims procedures of employee benefit plans covered by Title I of the Employee Retirement Income Security Act of 1974 (ERISA or the Act). This proposed regulation would establish new standards for the processing of group health disability, pension, and other employee benefit plan claims filed by participants and beneficiaries. In the case of group health plans, as well as certain plans providing disability benefits, the new standards are intended to ensure more timely benefit determinations, improved access to information on which a benefit determination is made, and greater assurance that participants and beneficiaries will be afforded a full and fair review of denied claims. If adopted as final, the proposed regulation would affect participants and beneficiaries of employee benefit plans, plan, fiduciaries, and others who assist in the provision of plan benefits, such as third-party benefits administrators and health service providers or health maintenance organizations that provide benefits to participants and beneficiaries of employee benefit plans.

  20. 7 CFR 201.3 - Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Administration § 201.3 Administrator. The Administrator of the Agricultural Marketing Service...

  1. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: Role of the ventral tegmental area and central nucleus of the amygdala

    PubMed Central

    Kenny, Paul J.; Chartoff, Elena; Roberto, Marisa; Carlezon, William A.; Markou, Athina

    2009-01-01

    Nicotine is considered an important component of tobacco responsible for the smoking habit in humans. Nicotine increases glutamate-mediated transmission throughout brain reward circuitries. This action of nicotine could potentially contribute to its intrinsic rewarding and reward-enhancing properties, which motivate consumption of the drug. Here we show that the competitive N-methyl-D-aspartate (NMDA) receptor antagonist LY235959 (0.5–2.5 mg/kg) abolished nicotine-enhanced brain reward function, reflected in blockade of the lowering of intracranial self-stimulation (ICSS) thresholds usually observed after experimenter-administered (0.25 mg/kg) or intravenously self-administered (0.03 mg/kg/infusion) nicotine injections. The highest LY235959 dose (5 mg/kg) tested reversed the hedonic valence of nicotine from positive to negative, reflected in nicotine-induced elevations of ICSS thresholds. LY235959 doses that reversed nicotine-induced lowering of ICSS thresholds also markedly decreased nicotine self-administration without altering responding for food reinforcement, whereas the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist NBQX had no effects on nicotine intake. In addition, nicotine self-administration upregulated NMDA receptor subunit expression in the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA), suggesting important interactions between nicotine and the NMDA receptor. Furthermore, nicotine (1 μM) increased NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in rat CeA slices, similar to its previously described effects in the VTA. Finally, infusion of LY235959 (0.1–10 ng/side) into the CeA or VTA decreased nicotine self-administration. Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug. PMID:18418357

  2. An overview of the joint FAA/NASA aircraft/ground runway friction program

    NASA Technical Reports Server (NTRS)

    Yager, Thomas J.

    1989-01-01

    There is a need for information on runways which may become slippery due to various forms and types of contaminants. Experience has shown that since the beginning of all weather aircraft operations, there have been landing and aborted takeoff incidents and/or accidents each year where aircraft have either run off the end or veered off the shoulder of low friction runways. NASA Langley's Landing and Impact Dynamics Branch is involved in several research programs directed towards obtaining a better understanding of how different tire properties interact with varying pavement surface characteristics to produce acceptable performance for aircraft ground handling requirements. One such effort, which was jointly supported by not only NASA and the FAA but by several aviation industry groups including the Flight Safety Foundation, is described.

  3. NASA,FAA,ONERA Swept-Wing Icing and Aerodynamics: Summary of Research and Current Status

    NASA Technical Reports Server (NTRS)

    Broeren, Andy

    2015-01-01

    NASA, FAA, ONERA, and other partner organizations have embarked on a significant, collaborative research effort to address the technical challenges associated with icing on large scale, three-dimensional swept wings. These are extremely complex phenomena important to the design, certification and safe operation of small and large transport aircraft. There is increasing demand to balance trade-offs in aircraft efficiency, cost and noise that tend to compete directly with allowable performance degradations over an increasing range of icing conditions. Computational fluid dynamics codes have reached a level of maturity that they are being proposed by manufacturers for use in certification of aircraft for flight in icing. However, sufficient high-quality data to evaluate their performance on iced swept wings are not currently available in the public domain and significant knowledge gaps remain.

  4. NASA/FAA Helicopter ATC simulation investigation of RNAV/MLS instrument approaches

    NASA Technical Reports Server (NTRS)

    Peach, L. L., Jr.; Tobias, L.; Lee, H. Q.

    1982-01-01

    The NASA/FAA Helicopter Air Traffic Control (ATC) simulation investigations to determine the feasibility of simultaneous, independent instrument approach procedures for helicopters at major terminal areas, using Area Navigation/Microwave Landing System (RNAV/MLS) guidance, was conducted at several levels of helicopter display sophistication, up to that of a Cockpit Display of Traffic Information (CDTI) system. Test objectives included the determination of pilot acceptability and the tracking performance of the RNAV/MLS's noninterfering rotorcraft approach path structure, along with the evaluation of the effect on controller workload of multiroute structures combining conventional and rotorcraft approaches at various arrival rates and traffic separations. The utility of electronic area maps and CDTI displays was also investigated. Participating pilots flew 127 simulated instrument approaches in an ATC simulation laboratory.

  5. CSLAA and FAA'S Rules: Incorporating a 'Risk Management Framework' to Minimise Human Space Flight Risks

    NASA Astrophysics Data System (ADS)

    Chaddha, S.

    2012-01-01

    th This year marks the 50 anniversary of a landmark victory for humankind in its endeavour of entering and exploring the final frontier. During these years of space activity, we have witnessed a number of cumulative successes. One of which is the emergence of the commercial human space flight, or "space tourism", market. Commercial companies have the aim of travelling people into space safely and affordably. This paper shall consider the U.S. regulatory framework governing the space tourism market. It scrutinises the adequacy of the Commercial Space Launch and Amendment Act of 2004 (CSLAA), as bolstered by the FAA's requirements, to protect launching passengers to an acceptable standard of safety from the inherent risks associated with human space flights. It is argued that the legislative regime embeds a three-limb "risk management framework" as an appropriate response to address the concern over the safety of public space travel.

  6. NASA-FAA helicopter Microwave Landing System curved path flight test

    NASA Technical Reports Server (NTRS)

    Swenson, H. N.; Hamlin, J. R.; Wilson, G. W.

    1983-01-01

    An ongoing series of joint NASA/FAA helicopter Microwave Landing System (MLS) flight tests was conducted at Ames Research Center. This paper deals with tests done from the spring through the fall of 1983. This flight test investigated and developed solutions to the problem of manually flying curved-path and steep glide slope approaches into the terminal area using the MLS and flight director guidance. An MLS-equipped Bell UH-1H helicopter flown by NASA test pilots was used to develop approaches and procedures for flying these approaches. The approaches took the form of Straight-in, U-turn, and S-turn flightpaths with glide slopes of 6 deg, 9 deg, and 12 deg. These procedures were evaluated by 18 pilots from various elements of the helicopter community, flying a total of 221 hooded instrument approaches. Flying these curved path and steep glide slopes was found to be operationally acceptable with flight director guidance using the MLS.

  7. Precision Departure Release Capability (PDRC) Overview and Results: NASA to FAA Research Transition

    NASA Technical Reports Server (NTRS)

    Engelland, Shawn; Davis, Tom.

    2013-01-01

    NASA researchers developed the Precision Departure Release Capability (PDRC) concept to improve the tactical departure scheduling process. The PDRC system is comprised of: 1) a surface automation system that computes ready time predictions and departure runway assignments, 2) an en route scheduling automation tool that uses this information to estimate ascent trajectories to the merge point and computes release times and, 3) an interface that provides two-way communication between the two systems. To minimize technology transfer issues and facilitate its adoption by TMCs and Frontline Managers (FLM), NASA developed the PDRC prototype using the Surface Decision Support System (SDSS) for the Tower surface automation tool, a research version of the FAA TMA (RTMA) for en route automation tool and a digital interface between the two DSTs to facilitate coordination.

  8. Automating test case generation for coverages required by FAA standard DO-178B

    NASA Technical Reports Server (NTRS)

    Voas, Jeffrey M.; Payne, Jeffery E.; Miller, Keith W.

    1993-01-01

    Coverage testing techniques are required by the FAA for various levels of subsystem criticality at the unit testing level. Higher levels of criticality require coverage schemes that frequently require more and more test cases, particularly when the number of conditions in a decision grows. For example, if we have a decision with n conditions of the form: if (/ci/ or /c2/ or .... or /cn/) then there are 2(n) possible combinations of condition outcomes. Given the enormous number of inputs that may be required to satisfy different coverages, and given that there are no automated tools for determining these inputs (to our knowledge), we will show how one alternative testing technique, mutation testing, can be coerced into generating inputs that satisfy a code coverage scheme X, i.e., if we modify the rules for mutant generation during mutation testing, this technique will provide test cases that satisfy X.

  9. Protein profiling of rat ventral prostate following chronic finasteride administration: identification and localization of a novel putative androgen-regulated protein.

    PubMed

    Cayatte, Corinne; Pons, Catherine; Guigonis, Jean-Marie; Pizzol, Jérôme; Elies, Laetitia; Kennel, Philippe; Rouquié, David; Bars, Rémi; Rossi, Bernard; Samson, Michel

    2006-11-01

    To better understand the effects of antiandrogens on the prostate, we investigated the changes in the proteome of rat ventral prostate (VP) following treatment with a well characterized 5alpha-reductase inhibitor, finasteride. Sprague-Dawley rats were treated daily by gavage with finasteride at 0, 1, 5, 25, and 125 mg/kg/day. Changes in plasma hormone levels as well as the weight and histology of sex accessory tissues were determined after 28 days of treatment and showed a dose-related decrease of VP weights together with a marked atrophy of the tissue visible at the macroscopic and microscopic levels. In addition, significant reductions in seminal vesicle and epididymis weights were noted. VP proteins were analyzed by two-dimensional gel electrophoresis: 37 proteins, mainly involved in protein synthesis, processing, and cellular trafficking and in metabolism, detoxification, and oxidative stress, were identified as modulated by finasteride. The prominent feature of this study is the demonstration of finasteride dose-dependent up-regulation of a protein similar to l-amino-acid oxidase 1 (Lao1). An up-regulation of this protein was also observed with the antiandrogen flutamide. Lao1 expression occurred as early as 48 h after antiandrogen administration and persisted throughout the treatment duration. Immunohistochemistry showed that this protein was only detectable in epithelial cells and secretory vesicles. Altogether these data point to a potential use of Lao1 to reveal antiandrogen-induced prostate injury.

  10. Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α(2)δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity.

    PubMed

    Yang, Yan; Yang, Fei; Yang, Fan; Li, Chun-Li; Wang, Yan; Li, Zhen; Lu, Yun-Fei; Yu, Yao-Qing; Fu, Han; He, Ting; Sun, Wei; Wang, Rui-Rui; Chen, Jun

    2016-02-01

    The α2δ-1 subunit of the voltage-gated Ca(2+) channel (VGCC) is a molecular target of gabapentin (GBP), which has been used as a first-line drug for the relief of neuropathic pain. GBP exerts its anti-nociceptive effects by disrupting trafficking of the α2δ-1 subunit to the presynaptic membrane, resulting in decreased neurotransmitter release. We previously showed that GBP has an anti-allodynic effect in the first two weeks; but this is followed by insensitivity in the later stage after repeated administration in a rat model of central post-stroke pain (CPSP) hypersensitivity induced by intra-thalamic hemorrhage. To explore the mechanisms underlying GBP insensitivity, the cellular localization and time-course of expression of the α2δ-1 subunit in both the thalamus and spinal dorsal horn were studied in the same model. We found that the α2δ-1 subunit was mostly localized in neurons, but not astrocytes and microglia. The level of α2δ-1 protein increased in the first two weeks after injury but then decreased in the third week, when GBP insensitivity occurred. Furthermore, the α2δ-1 down-regulation was likely caused by later neuronal loss in the injured thalamus through a mechanism other than apoptosis. In summary, the present results suggest that the GBP receptor α2δ-1 is mainly expressed in thalamic neurons in which it is up-regulated in the early stage of CPSP but this is followed by dramatic down-regulation, which is likely associated with GBP insensitivity after long-term use.

  11. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance Federal Aviation Administration Project 209 - Control Tower and Support Building, Las Vegas, NV

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-03-31

    This report represents findings of a design review team that evaluated construction documents (at the 70% level) and operating specifications for a new control tower and support building that will be built in Las Vegas, Nevada by the Federal Aviation Administration (FAA). The focus of the review was to identify measures that could be incorporated into the final design and operating specification that would result in additional energy savings for the FAA that would not have otherwise occurred.

  12. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance Federal Aviation Administration – Project 209 Control Tower and Support Building Oakland, CA

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-03-01

    This report represents findings of a design review team that evaluated construction documents (at the 70% level) and operating specifications for a new control tower and support building that will be build at Oakland, California by the Federal Aviation Administration (FAA). The focus of the review was to identify measures that could be incorporated into the final design and operating specification that would result in additional energy savings for the FAA that would not have otherwise occurred.

  13. Administrative Law Judges

    EPA Pesticide Factsheets

    The Administrative Law Judges conduct hearings and render decisions in proceedings between the EPA and persons, businesses, government entities, and other organizations which are or are alleged to be regulated under environmental laws.

  14. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  15. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  16. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  17. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  18. 49 CFR 1540.117 - Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 9 2013-10-01 2013-10-01 false Threat assessments regarding aliens holding or applying for FAA certificates, ratings, or authorizations. 1540.117 Section 1540.117 Transportation Other... Passengers and Other Individuals and Persons § 1540.117 Threat assessments regarding aliens holding...

  19. 14 CFR 11.35 - Does FAA include sensitive security information and proprietary information in the Federal Docket...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... information and proprietary information in the Federal Docket Management System (FDMS)? 11.35 Section 11.35... RULEMAKING PROCEDURES Rulemaking Procedures General § 11.35 Does FAA include sensitive security information and proprietary information in the Federal Docket Management System (FDMS)? (a) Sensitive...

  20. AVIATION SECURITY: FAA’s Actions to Study Responsibilities and Funding for Airport Security and to Certify Screening Companies

    DTIC Science & Technology

    1999-02-01

    Actions to Study Responsibilities and Funding for Airport Security and to Certify Screening Companies DISTRIBUTION STATEMENT A Approved for...local law enforcement support relating to air carrier and airport security measures. The funding of the security operations is divided among FAA, the...generally agreed with the current division of airport security responsibilities. These officials stated that the continuity of screening would be

  1. 14 CFR 11.101 - May I ask FAA to reconsider my petition for rulemaking or petition for exemption if it is denied?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... rulemaking or petition for exemption if it is denied? 11.101 Section 11.101 Aeronautics and Space FEDERAL... petition for rulemaking or petition for exemption if it is denied? Yes, you may petition FAA to reconsider... petition, and FAA must receive it within 60 days after we issued the denial. For us to accept your...

  2. 14 CFR 406.165 - Argument before the administrative law judge.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Argument before the administrative law judge. 406.165 Section 406.165 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.165 Argument before the...

  3. 14 CFR 406.165 - Argument before the administrative law judge.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Argument before the administrative law judge. 406.165 Section 406.165 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.165 Argument before the...

  4. 14 CFR 406.165 - Argument before the administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Argument before the administrative law judge. 406.165 Section 406.165 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.165 Argument before the...

  5. 14 CFR 406.165 - Argument before the administrative law judge.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Argument before the administrative law judge. 406.165 Section 406.165 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.165 Argument before the...

  6. 14 CFR 406.165 - Argument before the administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Argument before the administrative law judge. 406.165 Section 406.165 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION... Rules of Practice in FAA Space Transportation Adjudications § 406.165 Argument before the...

  7. Embracing 21st Century Information Sharing: Defining a New Paradigm for the Food and Drug Administration's Regulation of Biopharmaceutical Company Communications with Healthcare Professionals.

    PubMed

    Spears, James M; Francer, Jeffrey K; Turner, Natale A

    2015-01-01

    The Food and Drug Administration (FDA) plays a unique role in protecting the public health and minimizing the risk of the distribution of unsafe or ineffective medicines in the United States. Perhaps equally as important for public health, however, is the need for healthcare professionals to be well informed about the benefits and risks of the medicines they prescribe. In this way, information sharing is critical to healthcare delivery. FDA's current interpretation of laws and regulations governing healthcare communications prohibits biopharmaceutical companies from sharing certain accurate, data-driven information about FDA-approved uses and medically accepted alternative uses of FDA-approved drugs with healthcare professionals. Often, these uses are the standard of care for good medical practice and are, accordingly, reimbursed under the federal healthcare programs. FDA has failed to describe adequately how manufacturers can share truthful and non-misleading information about such uses with healthcare professionals and formulary decision makers. This failure could impede medical innovation, negatively impact patient care, and increase healthcare costs. To improve public health, FDA should reform its current approach and provide manufacturers with a clear safe harbor on how to share data and information on both approved uses and medically accepted alternative uses of FDA-approved drugs with healthcare professionals. This Article describes key principles for a new regulatory paradigm.

  8. Differential regulation of catalytic and non-catalytic trkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate.

    PubMed

    Dugich-Djordjevic, M M; Ohsawa, F; Okazaki, T; Mori, N; Day, J R; Beck, K D; Hefti, F

    1995-06-01

    Ribonuclease protection analysis and quantitative in situ hybridization histochemistry were used to investigate the coordination and regional expression of catalytic and non-catalytic trkB messenger RNAs in the adult rat hippocampus following systemic kainate-induced seizures. Changes in trkB expression were compared with the messenger RNA expression of its neurotrophic ligands, brain-derived neurotrophic factor and neurotrophin-3. TrkB messenger RNA expression was increased in the dentate granule cells at 1-4 h following the onset of seizures, and returned to control levels 16-24 h thereafter. In addition, seizures also induced expression of trkB messenger RNA in putative non-neuronal cells at four to seven days in the molecular layer of the dentate gyrus and the stratum lacunosum moleculare of the CA1 region. Hybridization with probes specific for the non-catalytic trkB receptor and the catalytic trkB receptor revealed that the increases at four and seven days in the molecular layers of the hippocampus reflected an up-regulation of only the non-catalytic form of the receptor. Furthermore, the neuronal increases observed 1-4 h were due to an up-regulation of both trkB TK- and trkB TK+ messenger RNAs. It was established that systemic administration of kainate increased brain-derived neurotrophic factor messenger RNA levels in the pyramidal and granule cell regions of the hippocampus 1-4 h following the onset of behaviorally manifested seizure activity. Early changes in neuronal expression of trkB TK- and trkB TK+ messenger RNA paralleled changes in brain-derived neurotrophic factor messenger RNA in the dentate granule cell and CA1 pyramidal cell layers, but not in the CA3 subregion. These data suggest that concomitant regulation of brain-derived neurotrophic factor and its cognate receptor may play a role in the selective vulnerability of hippocampal subregions to kainate-induced neuropathology. Furthermore, these data suggest a dual function for trkB receptor

  9. NASA/FAA flight-test investigation of helicopter microwave landing system approaches

    NASA Technical Reports Server (NTRS)

    Peach, I. L., Jr.; Bull, J. S.; Anderson, D. J.; Dugan, D. C.; Ross, V. L.; Hunting, A. W.; Pate, D. P.; Savage, J. C.

    1980-01-01

    The helicopter Microwave Landing System flight-test investigations, conducted by a joint NASA/FAA effort in order to gather statistical data for establishing terminal instrument procedures criteria, and to provide a performance data base for developing advanced MLS guidance concepts, are presented. The specific flight-test objectives were to: (1) develop acceptable angle-only MLS approach profiles; (2) determine tracking errors; (3) determine altitude loss during missed approach; (4) evaluate guidance display sensitivities; and (5) evaluate pilot acceptability. Fourteen pilots flew 140 manual (without stability augmentation) dual-pilot simulated instrument approaches in a UH-1H helicopter. The flight profiles flown included 3-, 6-, and 9-degree glideslope, centerline approaches to decision heights of 50, 100, and 150 ft, respectively. The angular guidance display sensitivities and the data acquisition system are also described. Eight major conclusions are made, and include the following: (1) the use of pitch attitude to control airspeed and collective to control glideslope was the preferred pilot technique for the steep glideslope approaches, and (2) angular guidance deviation indicator sensitivity requirements for helicopter MLS approaches to STOLports and heliports have been found to be significantly different from standard ILS sensitivities.

  10. Simplified multi-element analysis of ground and instant coffees by ICP-OES and FAAS.

    PubMed

    Szymczycha-Madeja, Anna; Welna, Maja; Pohl, Pawel

    2015-01-01

    A simplified alternative to the wet digestion sample preparation procedure for roasted ground and instant coffees has been developed and validated for the determination of different elements by inductively coupled plasma optical emission spectrometry (ICP-OES) (Al, Ba, Cd, Co, Cr, Cu, Mn, Ni, Pb, Sr, Zn) and flame atomic absorption spectrometry (FAAS) (Ca, Fe, K, Mg, Na). The proposed procedure, i.e. the ultrasound-assisted solubilisation in aqua regia, is quite fast and simple, requires minimal use of reagents, and demonstrated good analytical performance, i.e. accuracy from -4.7% to 1.9%, precision within 0.5-8.6% and recovery in the range 93.5-103%. Detection limits of elements were from 0.086 ng ml(-1) (Sr) to 40 ng ml(-1) (Fe). A preliminary classification of 18 samples of ground and instant coffees was successfully made based on concentrations of selected elements and using principal component analysis and hierarchic cluster analysis.

  11. [Determination of eight metal elements in Cichorium glandulosum Boiss et Huet by microwave digestion-FAAS].

    PubMed

    Pei, Ling-Peng; Zhou, Xiao-Ying; Cui, Jian; Pang, Zong-Ran; Liu, Hong-Bing; Ge, Liang

    2009-12-01

    The Cichorium glandulosum Boiss et Huet is a traditional Uighur natural herbal medicine, but has not been analyzed and studied in terms of its metal elements. In the experiment, the Cichorium glandulosum Boiss et Huet powder was digested with HNO3 by microwave digestion before determination. The eight metal elements, potassium, nickel, calcium, magnesium, iron, manganese, copper and zinc, in Cichorium glandulosum Boiss et Huet were determined by FAAS. The working conditions, accuracy and precision of the method were studied. The linear correlations of standard curves are good (r = 0.999 1-0.999 9). The recovery (n = 6) is 92.25%-110.5%, and the RSD (n = 6) is 0.7%-3.88%. The results showed that there were comparatively rich metal elements, among which are comparatively high calcium (65.84 mg x g(-1)), iron (24.38 mg x g(-1)), magnesium (278.17 mg x g(-1)) and potassium (18.50 mg x g(-1)), in Cichorium glandulosum Boiss et Huet, and the contents of other elements are nickel of 0.004 38 mg x g(-1), manganese of 0.52 mg x g(-1), copper of 0.016 5 mg x g(-1) and zinc of 0.18 mg x g(-1). This provided useful data for discussing the relationship between the content of the metal elements in Cichorium glandulosum Boiss et Huet and its clinical application in cardiovascular and osteoporosis disease.

  12. Determination of zinc in edible oils by flow injection FAAS after extraction induced by emulsion breaking procedure.

    PubMed

    Bakircioglu, Dilek; Topraksever, Nukte; Kurtulus, Yasemin Bakircioglu

    2014-05-15

    A new procedure using extraction induced by emulsion breaking (EIEB) procedure has been developed for extraction/preconcentration of zinc in various edible oils (canola oil, corn oil, hazelnut oil, olive oil, and sunflower oil) prior to its determination by the single line flow injection (FI) flame atomic absorption spectrometry (FAAS). Several parameters affecting the extraction efficiency of the procedure were investigated including the type and concentrations of surfactant, the concentration of HNO3, and the other operational conditions (emulsion breaking time and temperature). The limits of detection of 1.1 and 1.0 μg L(-1) were observed for zinc when aqueous standard and oil-based standards were added to the emulsions for calibration, respectively. The proposed procedure of combining EIEB and single line FI-FAAS can be regarded as a new procedure for the determination of zinc in edible oil samples.

  13. 49 CFR 385.711 - Administrative review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY FITNESS PROCEDURES... America-domiciled motor carrier may request FMCSA to conduct an administrative review if it believes...

  14. 48 CFR 3028.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Administration. 3028.106 Section 3028.106 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND SECURITY, HOMELAND SECURITY... 3028.106 Administration....

  15. Repeated administration of desipramine and a GABAB receptor antagonist, CGP 36742, discretely up-regulates GABAB receptor binding sites in rat frontal cortex.

    PubMed Central

    Pratt, G. D.; Bowery, N. G.

    1993-01-01

    1. GABAB receptor binding site densities within laminar regions of the rat frontal cortex were examined autoradiographically following repeated administration (21 days) of the antidepressants desipramine, paroxetine and amitriptyline in addition to the GABAB receptor antagonists, CGP 35348 and CGP 36742. beta 1-Adrenoceptor autoradiography was studied in parallel with that for GABAB receptor sites. 2. The effects of these compounds were examined concomitantly on the GABAB receptor-mediated inhibition of forskolin- and enhancement of noradrenaline-stimulated cyclic AMP production. 3. GABAB receptor binding was increased by both desipramine (20 mg kg-1, p.o. and 10 mg kg-1, i.p.) and CGP 36742 (100 mg kg-1, i.p.) in the outer laminar region of the frontal cortex by around 50% above control levels. Conversely, no significant changes were mediated by paroxetine, amitriptyline, CGP 35348 or the GABAB receptor agonist, baclofen. 4. With the exception of paroxetine, all compounds down-regulated the total beta-adrenoceptor population throughout frontal cortical laminae which was attributable to the beta 1-adrenoceptor subtype. In contrast, the reduction in beta-adrenoceptors mediated by CGP 35348 and CGP 36742 did not occur as a consequence of reduced beta 1-adrenoceptor numbers. 5. Protracted treatment with CGP 35348, failed to influence forskolin-stimulated cyclic AMP production; however, a significant increase in the accumulation of cyclic AMP produced in response to forskolin was seen after treatment with CGP 36742. 6. Such discretely localized changes in GABAB receptor densities induced by desipramine and CGP 36742 may provide an explanation for the discrepancies reported in membrane binding studies and possibly implicate a role for GABAB receptor antagonists in antidepressant therapy. Images Figure 1 Figure 3 PMID:8242244

  16. Impaired recovery of brain muscarinic receptor sites following an adaptive down-regulation induced by repeated administration of diisopropyl fluorophosphate in aged rats

    SciTech Connect

    Pintor, A.; Fortuna, S.; De Angelis, S.; Michalek, H. )

    1990-01-01

    Potential age-related differences in the recovery rate of brain cholinesterase activity (ChE) and muscarinic acetylcholine receptor binding sites (mAChRs) following reduction induced by repeated treatment with diisopropyl fluorophosphate (DFP) were evaluated in Sprague-Dawley rats. Male 3- and 24-month old rats were s.c. injected with DFP on alternate days for 2 weeks and killed 48 hr and 7, 14, 21, 28 and 35 days after the last treatment. In the hippocampus and striatum, but not in the cerebral cortex, of control rats there as a significant age-related decline of ChE activity and maximal density of 3H-QNB binding sites (Bmax). The repeated administration of DFP during the first week caused a syndrome of cholinergic stimulation both in aged and young rats. The syndrome was more pronounced, in terms of intensity and duration in aged than in young animals resulting in 40 and 12% mortality, respectively; during the second week the syndrome attenuated in the two age-groups. The percentage inhibition of brain ChE at the end of DFP treatment did not differ between young and surviving aged rats. The down-regulation of mACRs was present in the three brain regions of both young and age rats (from 20 to 40%). Factorial analysis of variance showed significant differences for age, recovery rate, and significant interaction between age and recovery rate, both for ChE and mAChRs in young rats the three brain areas.

  17. FAA Air Traffic Control Operations Concepts. Volume 3. ISSS (Initial Sector Suite System) En Route Controllers. Change 1

    DTIC Science & Technology

    1988-07-29

    series of ope-rations concepts for the FAA’s Advanced Automation System (AAS). It describes how en route controllers in Air Route Traffic Control Center...facilities may perform their operational jobs in the Initial Stector Suite System (ISSS) enviroinment- ISSS functionality is assumed to be as described...in the AAS System Level Specification, 28 August 1987. Included here are: Composition Graphs, showing the logizal flow of operational tasks performed

  18. [Determination of trace elements of Gentiana macrophlla and Gentiana straminea by microwave digestion-FAAS].

    PubMed

    Zhou, Yu-Shan; Zhang, Xi-Ling; Wang, Rong-Bin; Xia, Qi; An, Xia

    2008-05-01

    An acid-assisted microwave digestion procedure is optimized for the determination of trace elements in traditional Chinese medicine by the use of flame atomic absorption spectrometric (FAAS) techniques. Microwave-assisted digestion has the advantages of reduced time for sample dissolution, fewer possibilities for technical errors caused by spilling of hot digestion solutions, use of less chemicals, and lower losses of volatile metals. In addition, modern microwave ovens are safer and simpler and provide more controlled and reproducible conditions than hot plate or block digesters. Flame atomic absorption spectrometry (FAAS) is more commonly applied techniques in the de termination of trace elements. The accurate measurement of trace elements concentrations in samples of traditional Chinese medicine is an important goal in research for medical effects of traditional Chinese medicine. The purpose of this study was to determine the contents of the trace elements in Gentiana macrophlla and Gentiana straminea. In order to identify the accuracy of the procedure, the operating conditions was selected before the determination of trace elements. In order to gauge the effectiveness of digestion, the selection of digestion conditions of the technique was undertaken. The results showed HNO3-H2O2 (5 : 1) as a microwave digestion agent with suitable temperature and time was optimum choice in the digestion procedure. Analysis limits were also selected according to the low detection limits and the good precision. They were Fe(248.3 nm), Mn (279.5 nm), Ni (232.0 nm), Cu(324. 8 nm), Zn (2.139 nm), Ca (422.7 nm), Mg (285.2 nm) and Cr (357.9 nm), respectively. The working curves were obtained by using multi-elemental standard solutions and line relation was good. Under the selected conditions, the contents of trace elements Fe, Mn, Ni, Cu, Zn, Ca, Mg and Cr in Gentiana macrophlla and Gentiana straminea were directly determined using working curve methods. The relative standard

  19. Administrative Synergy

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  20. Biomimetic FAA-certifiable, artificial muscle structures for commercial aircraft wings

    NASA Astrophysics Data System (ADS)

    Barrett, Ronald M.; Barrett, Cassandra M.

    2014-07-01

    This paper is centered on a new form of adaptive material which functions much in the same way as skeletal muscle tissue, is structurally modeled on plant actuator cells and capable of rapidly expanding or shrinking by as much as an order of magnitude in prescribed directions. Rapid changes of plant cell shape and sizes are often initiated via ion-transport driven fluid migration and resulting turgor pressure variation. Certain plant cellular structures like those in Mimosa pudica (sensitive plant), Albizia julibrissin (Mimosa tree), or Dionaea muscipula (Venus Flytrap) all exhibit actuation physiology which employs such turgor pressure manipulation. The paper begins with dynamic micrographs of a sectioned basal articulation joint from A. julibrissin. These figures show large cellular dimensional changes as the structure undergoes foliage articulation. By mimicking such structures in aircraft flight control mechanisms, extremely lightweight pneumatic control surface actuators can be designed. This paper shows several fundamental layouts of such surfaces with actuator elements made exclusively from FAA-certifiable materials, summarizes their structural mechanics and shows actuator power and energy densities that are higher than nearly all classes of conventional adaptive materials available today. A sample flap structure is shown to possess the ability to change its shape and structural stiffness as its cell pressures are manipulated, which in turn changes the surface lift-curve slope when exposed to airflows. Because the structural stiffness can be altered, it is also shown that the commanded section lift-curve slope can be similarly controlled between 1.2 and 6.2 rad-1. Several aircraft weight reduction principles are also shown to come into play as the need to concentrate loads to pass through point actuators is eliminated. The paper concludes with a summary of interrelated performance and airframe-level improvements including enhanced gust rejection, load

  1. 48 CFR 702.170-2 - Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administrator. 702.170-2 Section 702.170-2 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT GENERAL DEFINITIONS OF WORDS AND TERMS Definitions 702.170-2 Administrator. Administrator means the Administrator...

  2. Rapid and sensitive ultrasonic-assisted derivatisation microextraction (UDME) technique for bitter taste-free amino acids (FAA) study by HPLC-FLD.

    PubMed

    Chen, Guang; Li, Jun; Sun, Zhiwei; Zhang, Shijuan; Li, Guoliang; Song, Cuihua; Suo, Yourui; You, Jinmao

    2014-01-15

    Amino acids, as the main contributors to taste, are usually found in relatively high levels in bitter foods. In this work, we focused on seeking a rapid, sensitive and simple method to determine FAA for large batches of micro-samples and to explore the relationship between FAA and bitterness. Overall condition optimisation indicated that the new UDME technique offered higher derivatisation yields and extraction efficiencies than traditional methods. Only 35min was needed in the whole operation process. Very low LLOQ (Lower limit of quantification: 0.21-5.43nmol/L) for FAA in twelve bitter foods was obtained, with which BTT (bitter taste thresholds) and CABT (content of FAA at BTT level) were newly determined. The ratio of CABT to BTT increased with decreasing of BTT. This work provided powerful potential for the high-throughput trace analysis of micro-sample and also a methodology to study the relationship between the chemical constituents and the taste.

  3. [Italian Decree D.lgs 231/2001--"Regulations regarding administrative responsibilities of corporate bodies of Companies and Associations including those not legally recognized"--an organizational model for the healthcare area].

    PubMed

    Roberti, Giovanni; Fiore, Rosalia; Franco, Claudia; Pimpinella, Giovanni; Piscioneri, Patrizia

    2010-01-01

    Healthcare organizations must implement organizational and management models of regulation and control systems for effectively preventing possible administrative torts by personnel. We define an organizational management and control model for healthcare organizations, based on the legal dispositions of Decree n.231/2001. The model identifies critical points in the administrative and healthcare services delivery processes that are at high-risk of violations to the code. Its primary aim is to prevent torts by the personnel and safeguard the organization at the same time.

  4. 5 CFR 831.101 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Administration. 831.101 Section 831.101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Administration and General Provisions § 831.101 Administration. (a) OPM has charge of...

  5. 7 CFR 56.3 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Administration. 56.3 Section 56.3 Agriculture... EGGS Grading of Shell Eggs General § 56.3 Administration. The Administrator shall perform, for and... administration of the provisions of the Act and the regulations in this part. The Administrator is authorized...

  6. 7 CFR 56.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Administration. 56.3 Section 56.3 Agriculture... EGGS Grading of Shell Eggs General § 56.3 Administration. The Administrator shall perform, for and... administration of the provisions of the Act and the regulations in this part. The Administrator is authorized...

  7. 5 CFR 179.307 - Administrative offset.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Administrative offset. 179.307 Section 179.307 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Administrative Offset § 179.307 Administrative offset. (a) If the debtor does...

  8. 77 FR 55829 - Western Area Power Administration; Grapevine Canyon Wind Project Record of Decision (DOE/EIS-0427)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... would generate up to 500 megawatts of electricity from wind turbine generators (WTGs). The proposed... wind park and transmission tie-line facilities. To implement the RPMs, an Avian and Bat Protection Plan... lights on wind turbine generators per Federal Aviation Administration (FAA) requirements. Per a RPM...

  9. Administrative Ecology

    ERIC Educational Resources Information Center

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  10. 14 CFR Appendix B to Part 187 - Fees for FAA Services for Certain Flights

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... either directly owned by the United States or allocated to the United States by the International Civil Aviation Organization (ICAO) or by other countries. This is further defined, for this section only, as... Appendix B to Part 187 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF...

  11. Human Factors at the FAA Technical Center: Bibliography 1958-1994.

    DTIC Science & Technology

    1994-12-01

    Rosenberg, B. L. (1967). An inexpensive random-noise generator. Journal of the Experimental Analysis of Behavior , 10, 373-374. Atlantic City, NJ...purpose timer. Journal of the Experimental Analysis of Behavior , 10, 383-385. Atlantic City, NJ: Federal Aviation Administration Technical Center. 198

  12. Oral administration of Bifidobacterium bifidum G9-1 alleviates rotavirus gastroenteritis through regulation of intestinal homeostasis by inducing mucosal protective factors

    PubMed Central

    Kawahara, Tomohiro; Makizaki, Yutaka; Oikawa, Yosuke; Tanaka, Yoshiki; Maeda, Ayako; Shimakawa, Masaki; Komoto, Satoshi; Moriguchi, Kyoko; Ohno, Hiroshi; Taniguchi, Koki

    2017-01-01

    Human rotavirus (RV) infection is a leading cause of dehydrating diarrhea in infants and young children worldwide. Since therapeutic approaches to RV gastroenteritis are limited to alleviation of dehydration with oral rehydration solutions, more direct approaches to palliate symptoms of RV gastroenteritis are required. Treatments with probiotics have been increasingly recognized as alternative safe and low cost treatments for moderate infectious diarrhea. In this study, Bifidobacterium bifidum G9-1 (BBG9-1), which has been used as an intestinal drug for several decades, was shown to have a remarkable protective effect against RV gastroenteritis in a suckling mice model. As well as prophylactic oral administration of BBG9-1 from 2 days before RV infection, therapeutic oral administration of BBG9-1 from 1 day after RV infection significantly alleviated RV-induced diarrhea. Therapeutic administration of BBG9-1 reduced various types of damage in the small intestine, such as epithelial vacuolization and villous shortening, and significantly diminished the infectious RV titer in mixtures of cecal contents and feces. It was also shown that therapeutic administration of BBG9-1 significantly increased the number of acidic mucin-positive goblet cells and the gene expression of mucosal protective factors including MUC2, MUC3, MUC4, TGFβ1 and TFF3 in the small intestine. This led to alleviation of low gut permeability shown as decreased gene expression levels of occludin, claudin-1 and villin-1 after RV infection. Furthermore, in the small intestine, therapeutic administration of BBG9-1 significantly palliated the decreased gene expression of SGLT-1, which plays an important role in water absorption. In the large intestine, administered BBG9-1 was shown to replicate to assimilate undigested nutrients, resulting in normalization of the abnormally high osmotic pressure. These results suggested that water malabsorption caused by RV infection was alleviated in mice administered

  13. 7 CFR 57.10 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Administration. 57.10 Section 57.10 Agriculture... PRODUCTS INSPECTION ACT) Regulations Governing the Inspection of Eggs General § 57.10 Administration. The... require in the enforcement or administration of the provisions of the act and the regulations in this...

  14. 7 CFR 57.10 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Administration. 57.10 Section 57.10 Agriculture... PRODUCTS INSPECTION ACT) Regulations Governing the Inspection of Eggs General § 57.10 Administration. The... require in the enforcement or administration of the provisions of the act and the regulations in this...

  15. Results from FAA program to validate bonded composite doublers for commercial aviation use

    SciTech Connect

    Roach, D.P.

    1997-09-01

    The number of commercial airframes exceeding twenty years of service continues to grow. In addition, Service Life Extension Programs are attempting to extend the {open_quotes}economic{close_quotes} service life of commercial airframes to thirty years. The use of bonded composites may offer the airframe manufacturers and aircraft maintenance facilities a cost effective method to extend the lives of their aircraft. The Federal Aviation Administration Assurance NDI Validation Center (AANC) to validate the use of bonded composite doublers on commercial aircraft.

  16. FAA Helicopter/Heliport Research, Engineering, and Development Bibiliography, 1964-1986.

    DTIC Science & Technology

    1986-11-01

    well as a means to determine -.. the effects of aircraft weight and altitude on the H-V diagram. Analysis disclosed that H-V diagrams can be developed...This investigation included current aircraft needs as well as facilities that might be required for icing research, development and certification...within the Federal Avi.ation Administration JAA), those in industry, and those in state arnd local qoverom6nts. 2. SCOPE. ln selecting documents to be

  17. 5 CFR 179.307 - Administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Administrative offset. 179.307 Section... COLLECTION STANDARDS Administrative Offset § 179.307 Administrative offset. (a) If the debtor does not... offset shall be ordered in accordance with these regulations without further notice. (b) Request...

  18. 9 CFR 381.3 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Administration. 381.3 Section 381.3... CERTIFICATION POULTRY PRODUCTS INSPECTION REGULATIONS Administration; Application of Inspection and Other Requirements § 381.3 Administration. (a) (b) The Administrator may in specific classes of cases waive...

  19. 7 CFR 29.51 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Administration. 29.51 Section 29.51 Agriculture... INSPECTION Regulations Administration § 29.51 Administration. The Director is charged with the supervision of the Division and the performance of all duties assigned thereto in the administration of the...

  20. 9 CFR 354.3 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Administration. 354.3 Section 354.3... CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND EDIBLE PRODUCTS THEREOF Administration § 354.3 Administration... prescribed in the regulations in this part and as the Secretary may require in the administration of...

  1. 7 CFR 29.51 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Administration. 29.51 Section 29.51 Agriculture... INSPECTION Regulations Administration § 29.51 Administration. The Director is charged with the supervision of the Division and the performance of all duties assigned thereto in the administration of the...

  2. 5 CFR 351.705 - Administrative assignment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Administrative assignment. 351.705 Section 351.705 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Assignment Rights (Bump and Retreat) § 351.705 Administrative assignment. (a) An...

  3. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  4. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  5. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 2 2014-10-01 2014-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  6. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  7. 48 CFR 53.204 - Administrative matters.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 2 2013-10-01 2013-10-01 false Administrative matters. 53.204 Section 53.204 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.204 Administrative matters....

  8. 48 CFR 28.106 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Administration. 28.106 Section 28.106 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 28.106 Administration....

  9. 48 CFR 228.106 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Administration. 228.106 Section 228.106 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.106 Administration....

  10. 48 CFR 228.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 228.106 Section 228.106 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 228.106 Administration....

  11. 48 CFR 53.242 - Contract administration.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 2 2012-10-01 2012-10-01 false Contract administration. 53.242 Section 53.242 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.242 Contract administration....

  12. 48 CFR 53.242 - Contract administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contract administration. 53.242 Section 53.242 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION (CONTINUED) CLAUSES AND FORMS FORMS Prescription of Forms 53.242 Contract administration....

  13. Policies, Procedures, Guidelines, Rules and Regulations for the Administration and Operation of Public Junior Colleges. (Compilation of Existing Actions of the Illinois Junior College Board.)

    ERIC Educational Resources Information Center

    Illinois Community Coll. Board, Springfield.

    This document is a compilation of existing policies, procedures, guidelines, rules, and regulations previously adopted by the Illinois Junior College Board, from its establishment in September 1965 through May 1973. Also in the document is a listing of due dates for various documents that are to be sent to the board office during the following…

  14. Engineering Administration.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    This book is intended to acquaint naval engineering officers with their duties in the engineering department. Standard shipboard organizations are analyzed in connection with personnel assignments, division operations, and watch systems. Detailed descriptions are included for the administration of directives, ship's bills, damage control, training…

  15. Administrative IT

    ERIC Educational Resources Information Center

    Grayson, Katherine, Ed.

    2006-01-01

    When it comes to Administrative IT solutions and processes, best practices range across the spectrum. Enterprise resource planning (ERP), student information systems (SIS), and tech support are prominent and continuing areas of focus. But widespread change can also be accomplished via the implementation of campuswide document imaging and sharing,…

  16. Database Administrator

    ERIC Educational Resources Information Center

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  17. Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice

    PubMed Central

    Gallardo, Christian M; Darvas, Martin; Oviatt, Mia; Chang, Chris H; Michalik, Mateusz; Huddy, Timothy F; Meyer, Emily E; Shuster, Scott A; Aguayo, Antonio; Hill, Elizabeth M; Kiani, Karun; Ikpeazu, Jonathan; Martinez, Johan S; Purpura, Mari; Smit, Andrea N; Patton, Danica F; Mistlberger, Ralph E; Palmiter, Richard D; Steele, Andrew D

    2014-01-01

    Daily rhythms of food anticipatory activity (FAA) are regulated independently of the suprachiasmatic nucleus, which mediates entrainment of rhythms to light, but the neural circuits that establish FAA remain elusive. In this study, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly reduced FAA, whereas mice lacking the dopamine D2 receptor have normal FAA. To determine where dopamine exerts its effect, we limited expression of dopamine signaling to the dorsal striatum of dopamine-deficient mice; these mice developed FAA. Within the dorsal striatum, the daily rhythm of clock gene period2 expression was markedly suppressed in D1R KO mice. Pharmacological activation of D1R at the same time daily was sufficient to establish anticipatory activity in wild-type mice. These results demonstrate that dopamine signaling to D1R-expressing neurons in the dorsal striatum plays an important role in manifestation of FAA, possibly by synchronizing circadian oscillators that modulate motivational processes and behavioral output. DOI: http://dx.doi.org/10.7554/eLife.03781.001 PMID:25217530

  18. FirstAidAssistanceSystem (FAAS): improvement of first aid measures using Car2Car-communication technology

    NASA Astrophysics Data System (ADS)

    Tuchscheerer, Sven; Hoppe, Tobias; Krätzer, Christian; Dittmann, Jana

    2011-01-01

    This work's goal is the enhancement of first aid measures directly after car accidents by calling suited first aiders via Car-to-Car (C2C) communication and to assist them providing detailed multimedia support instructions. Our concept combines upcoming C2C communication technologies with established technology, in particular GPS and GSM. After a collision, the proposed FirstAidAssistanceSystem (FAAS) sends a broadcast message using C2C technology according to the IEEE 802.11p standard. All nearby cars (as potential first aiders) are located and at least one nearest candidate (we suggest 3-5) driving towards the accident scene is chosen and notified as first aider. A support guide on his multipurpose display (e.g. the navigation system) provides first aiders with detailed instructions and illustrative tutorials. The paper presents our concept in detail with a discussion of practical evaluation criteria and an introduction of a first test implementation.

  19. Subcutaneous administration of collagen-polyvinylpyrrolidone down regulates IL-1beta, TNF-alpha, TGF-beta1, ELAM-1 and VCAM-1 expression in scleroderma skin lesions.

    PubMed

    Furuzawa-Carballeda, J; Krötzsch, E; Barile-Fabris, L; Alcalá, M; Espinosa-Morales, R

    2005-01-01

    In this study the effect of collagen-polyvinylpyrrolidone (collagen-PVP) vs. triamcinolone acetonide (Triam) in scleroderma (SSc) skin lesions was evaluated. Ten SSc patients were treated weekly with subcutaneous injections of 0.2 mL Triam (8 mg/mL) or 0.2 mL collagen-PVP (1.66 mg collagen). Skin biopsies were obtained from lesions before and after treatment. Tissue sections were evaluated by histology and immunohistochemistry (ELAM-1, VCAM-1, IL-1beta, TNF-alpha, TGF-beta1 and PDGF). The corticoid-treated group showed abnormal tissue architecture while the biodrug-treatment restored cutaneous appendages and type I/III collagen proportion. Cytokine and adhesion molecule expression was almost inhibited with Triam, while collagen-PVP down-regulated it. Collagen-PVP improved the tissue architecture of SSc lesions and down-regulated some proinflammatory parameters, without the side effects induced by corticoids.

  20. Knockdown of μ-calpain in Fanconi Anemia, FA-A, cells by siRNA Restores αII Spectrin levels and Corrects Chromosomal Instability and Defective DNA Interstrand Cross-link Repair†

    PubMed Central

    Zhang, Pan; Sridharan, Deepa; Lambert, Muriel W.

    2010-01-01

    We have previously shown that there is a deficiency in the structural protein, nonerythroid α spectrin (αIISp), in cells from patients with Fanconi anemia (FA). These studies indicate that this deficiency is due to reduced stability of αIISp and correlates with decreased repair of DNA interstrand cross-links and chromosomal instability in FA cells. An important factor in the stability of αIISp is its susceptibility to cleavage by the protease, μ-calpain. We hypothesized that increased μ-calpain cleavage of αIISp in FA cells leads to increased breakdown of αIISp and that knocking-down expression of μ-calpain in FA cells should restore levels of αIISp and correct a number of the phenotypic defects observed. The results showed that there is increased μ-calpain activity in FA-A, FA-C, FA-D2, FA-F and FA-G cells which could account for the deficiency in αIISp in these FA cells. Protein interaction studies indicated that FANCA and FANCG bind directly to μ-calpain. We hypothesize that this binding may lead to inhibition of μ-calpain activity in normal cells. Knocking-down μ-calpain by siRNA in FA-A cells restored levels of αIISp to normal and reversed a number of the cellular deficiencies in these cells. It corrected the DNA repair defect and the chromosomal instability observed after exposure to a DNA interstrand cross-linking agent. These studies indicated that FA proteins may play an important role in maintaining stability of αIISp in the cell by regulating its cleavage by μ-calpain. Thus by reducing breakdown of αIISp in FA cells, it may be possible to reverse a number of the cellular deficiencies observed in this disorder. PMID:20518497

  1. American Recovery and Reinvestment Act (ARRA) FEMP Technical Assistance Federal Aviation Administration – Project 209 Control Tower and Support Building, Reno, Nevada

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-06-30

    Pacific Northwest National Laboratory (PNNL) and Redhorse Corporation (Redhorse) conducted an energy audit on the Federal Aviation Administration (FAA) control tower and base building in Reno, Nevada. This report presents the findings of the energy audit team that evaluated construction documents and operating specifications (at the 100% level) and completed a site visit. The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for the FAA that would not have otherwise occurred.

  2. American Recovery and Reinvestment Act (ARRA) - FEMP Technical Assistance - Federal Aviation Administration - Project 209 - Control Tower and Support Building, Boise, Idaho

    SciTech Connect

    Arends, J.; Sandusky, William F.

    2010-06-28

    This report documents an energy audit performed by Pacific Northwest National Laboratory (PNNL) and Redhorse Corporation (Redhorse) conducted on the Federal Aviation Administration (FAA) control tower and base building in Boise, Idaho. This report presents findings of the energy audit team that evaluated construction documents and operating specifications (at the 100% level) followed by a site visit of the facility under construction. The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for FAA that would not have otherwise occurred.

  3. Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs.

    PubMed

    Taniguchi, Shin; Ryu, Junnosuke; Seki, Masayuki; Sumino, Takanobu; Tokuhashi, Yasuaki; Esumi, Mariko

    2012-05-01

    Histological and molecular changes were examined to investigate the effects of long-term administration of glucosamine (GlcN) and chondroitin sulfate (CS) in a model of spontaneous osteoarthritis (OA) in Hartley guinea pigs. Three groups of female 3-week-old Hartley guinea pigs received GlcN, CS, and neither agent, respectively. Five animals in each group were sacrificed at 8, 12, and 18 months of age. At 8 months of age, Hartley guinea pigs had severe degeneration of knee joint cartilage, chondrocyte apoptosis, marked reduction of tissue total RNA, decreases of aggrecan and collagen type 2 mRNAs, and increases in MMP-3 and MMP-8 mRNAs. Long-term administration of GlcN and CS reduced cartilage degeneration at 8 months of age. The marked loss of total RNA and the increase in MMP-3 mRNA were also inhibited by GlcN and CS. Thus, long-term oral administration of GlcN or CS inhibits OA progression, maintains total RNA and down-regulates MMP-3 mRNA in a spontaneous OA model in Hartley guinea pigs.

  4. Deficits in coordinated motor behavior and in nigrostriatal dopaminergic system ameliorated and VMAT2 expression up-regulated in aged male rats by administration of testosterone propionate.

    PubMed

    Wang, Li; Kang, Yunxiao; Zhang, Guoliang; Zhang, Yingbo; Cui, Rui; Yan, Wensheng; Tan, Huibing; Li, Shuangcheng; Wu, Baiyila; Cui, Huixian; Shi, Geming

    2016-06-01

    The effects of testosterone propionate (TP) supplements on the coordinated motor behavior and nigrostriatal dopaminergic (NSDA) system were analyzed in aged male rats. The present study showed the coordinated motor behavioral deficits, the reduced activity of NSDA system and the decreased expression of vesicular monoamine transporter 2 (VMAT2) in 24 month-old male rats. Long term TP treatment improved the motor coordination dysfunction with aging. Increased tyrosine hydroxylase and dopamine transporter, as well as dopamine and its metabolites were found in the NSDA system of TP-treated 24 month-old male rats, indicative of the amelioratory effects of TP supplements on NSDA system of aged male rats. The enhancement of dopaminergic (DAergic) activity of NSDA system by TP supplements might underlie the amelioration of the coordinated motor dysfunction in aged male rats. TP supplements up-regulated VMAT2 expression in NSDA system of aged male rats. Up-regulation of VMAT2 expression in aged male rats following chronic TP treatment might be involved in the maintenance of DAergic function of NSDA system in aged male rats.

  5. Determination of Fe Content of Some Food Items by Flame Atomic Absorption Spectroscopy (FAAS): A Guided-Inquiry Learning Experience in Instrumental Analysis Laboratory

    ERIC Educational Resources Information Center

    Fakayode, Sayo O.; King, Angela G.; Yakubu, Mamudu; Mohammed, Abdul K.; Pollard, David A.

    2012-01-01

    This article presents a guided-inquiry (GI) hands-on determination of Fe in food samples including plantains, spinach, lima beans, oatmeal, Frosted Flakes cereal (generic), tilapia fish, and chicken using flame atomic absorption spectroscopy (FAAS). The utility of the GI experiment, which is part of an instrumental analysis laboratory course,…

  6. Evaluation of lubricating oil preparation procedures for the determination of Al, Ba, Mo, Si and V by high-resolution continuum source FAAS.

    PubMed

    Amorim Filho, Volnei Resta; Gomes Neto, José Anchieta

    2009-01-01

    Microwave-assisted acid decomposition and oil-in-water emulsification were evaluated as sample pretreatment procedures to determine Al, Ba, Mo, Si and V in lubricating oils by high-resolution continuum source flame atomic absorption spectrometry (HR-CS FAAS). Average recoveries of Al, Ba and V in oil digests (107, 103 and 101%) were close to those obtained for emulsions prepared in kerosene medium (94, 113 and 95%). Average recoveries for Mo were close to 105 and 46% for emulsions and digests, respectively. Improved average recoveries (101%) were obtained for Mo in digests using the analyte addition technique. Silicon was successfully quantified only in digested samples. Limits of quantification for Al, Ba, Mo and V were 1.4, 31.5, 1.5 and 11.4-fold lower than those obtained by line-source FAAS. Enhanced sensitivity, multi-elemental capability, and high sample throughput are among the main advantages of HR-CS FAAS in comparison with the line-source FAAS technique.

  7. Aircraft and ground vehicle friction correlation test results obtained under winter runway conditions during joint FAA/NASA Runway Friction Program

    NASA Technical Reports Server (NTRS)

    Yager, Thomas J.; Vogler, William A.; Baldasare, Paul

    1988-01-01

    Aircraft and ground vehicle friction data collected during the Joint FAA/NASA Runway Friction Program under winter runway conditions are discussed and test results are summarized. The relationship between the different ground vehicle friction measurements obtained on compacted snow- and ice-covered conditions is defined together with the correlation to aircraft tire friction performance under similar runway conditions.

  8. Oral Administration of Achyranthis radix Extract Prevents TMA-induced Allergic Contact Dermatitis by Regulating Th2 Cytokine and Chemokine Production in Vivo.

    PubMed

    Jung, Sung Keun; Choi, Dae Woon; Kwon, Da-Ae; Kim, Min Jung; Seong, Ki Seung; Shon, Dong-Hwa

    2015-12-03

    Allergic contact dermatitis (ACD) remains a major skin disease in many countries, necessitating the discovery of novel and effective anti-ACD agents. In this study, we investigated the preventive effects of Achyranthis radix extract (AcRE) on trimellitic anhydride (TMA)-induced dermatitis and the potential mechanism of action involved. Oral administration of AcRE and prednisolone (PS) significantly suppressed TMA-induced increases in ear and epidermal thickness, and IgE expression. In addition, abnormal expression of IL-1β and TNF-α protein and mRNA was also significantly attenuated by oral administration of AcRE. Treatment with AcRE also significantly suppressed TMA-induced IL-4 and IL-13 cytokines and mRNA expression in vivo. Moreover, AcRE strongly suppressed TMA-induced IL-4 and IL-5 production in draining lymph nodes, as well as OVA-induced IL-4 and IL-5 expression in primary cultured splenocytes. Interestingly, AcRE suppressed IL-4-induced STAT6 phosphorylation in both primary cultured splenocytes and HaCaT cells, and TMA-induced GATA3 mRNA expression ex vivo. AcRE also suppressed TMA-mediated CCL11 and IL-4-induced CCL26 mRNA expression and infiltration of CCR3 positive cells. The major compounds from AcRE were identified as gentisic acid (0.64 ± 0.2 μg/g dry weight of AcRE), protocatechuic acid (2.69 ± 0.1 μg/g dry weight of AcRE), 4-hydroxybenzoic acid (5.59 ± 0.3 μg/g dry weight of AcRE), caffeic acid (4.21 ± 0.1 μg/g dry weight of AcRE), and ferulic acid (14.78 ± 0.4 ± 0.3 μg/g dry weight of AcRE). Taken together, these results suggest that AcRE has potential for development as an agent to prevent and treat allergic contact dermatitis.

  9. Regulating private human suborbital flight at the international and European level: Tendencies and suggestions

    NASA Astrophysics Data System (ADS)

    Masson-Zwaan, Tanja; Moro-Aguilar, Rafael

    2013-12-01

    In the context of the FAST20XX project (Future High-Altitude High-Speed Transport) that started in 2009 under the 7th Framework Programme of the European Union (EU), the authors reexamined the legal status of private human suborbital flight, and researched whether it might be regulated as aviation or as spaceflight. International space law is ambiguous as to accommodating suborbital activities. While some provisions of the UN outer space treaties would seem to exclude them, generally there is not any explicit condition in terms of reaching orbit as a requirement for application. International air law presents equal difficulties in dealing with this activity. The classic definition of "aircraft" as contained in the Annexes to the Chicago Convention does not really encompass the kind of rocket-powered vehicles that are envisaged here. As a result, it is unclear whether the United Nations Committee on the Peaceful Uses of Outer Space (COPUOS), the International Civil Aviation Organization (ICAO), or both could be involved in an eventual international regulation of suborbital flight. In the absence of a uniform international regime, each state has the sovereign right to regulate human suborbital flights operating within its airspace. So far, two practical solutions have been realised or proposed, and will be analyzed. On the one hand, the USA granted power for regulation and licensing over private human suborbital flight to the Office of Commercial Space Transportation of the Federal Aviation Administration (FAA/AST). Subsequent regulations by the FAA have set out a series of requirements for companies that want to operate these flights, enabling a market to develop. On the other side of the Atlantic, both the European Space Agency (ESA) and a group of representatives of the European Aviation Safety Agency (EASA) of the European Union (EU) seem to rather regard this activity as aviation, potentially subject to the regulation and certification competences of EASA

  10. International Health Regulations (2005) facilitate communication for in-flight contacts of a Middle East respiratory syndrome case, Hong Kong Special Administrative Region, 2014

    PubMed Central

    Miu-ling, Wong; Yiu-hong, Leung; Ka-wai, Sin; Liza, To May-kei; Shuk-kwan, Chuang

    2015-01-01

    The International Health Regulations (IHR) (2005) require World Health Organization Member States to notify events fulfilling two of four criteria: (1) serious public health impact; (2) unusual or unexpected event; (3) significant risk of international spread; or (4) significant risk of international travel or trade restrictions.1 In-flight transmission of infections like severe acute respiratory syndrome is well documented.2 With the enormous amount of air travel today, the risk of increasing in-flight transmission and subsequent international spread of infections are increasing. Prompt notification and information sharing under the IHR mechanism is critical for effective contact tracing and prompt control measures. We report on a case of in-flight exposure to an infection with significant public health risks that was successfully resolved using IHR (2005) guidelines. PMID:25960925

  11. 32 CFR 700.722 - Administration and discipline: Staff unassigned to an administrative command.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 5 2010-07-01 2010-07-01 false Administration and discipline: Staff unassigned... REGULATIONS AND OFFICIAL RECORDS Commanders In Chief and Other Commanders Administration and Discipline § 700.722 Administration and discipline: Staff unassigned to an administrative command. (a) When it is...

  12. Down regulation of trophic factors in neonatal rat spinal cord after administration of cerebrospinal fluid from sporadic amyotrophic lateral sclerosis patients.

    PubMed

    Deepa, P; Shahani, Neelam; Alladi, Phalguni Anand; Vijayalakshmi, K; Sathyaprabha, T N; Nalini, A; Ravi, V; Raju, T R

    2011-04-01

    Accumulating evidence supports neuroprotective role of trophic factors in amyotrophic lateral sclerosis (ALS). Previous studies from our laboratory report that the CSF of patients with sporadic ALS (ALS-CSF) induces degenerative changes in the rat spinal motor neurons and reactive astrogliosis in the surrounding gray matter. The present study was aimed to investigate if the ALS-CSF affected the expression of trophic factors namely, brain-derived neurotrophic factor (BDNF), fibroblast growth factor 2 (FGF2) and insulin-like growth factor 1 (IGF1) in the newborn rat spinal cords. ALS-CSF was intrathecally injected into the neonatal rats and the mRNA levels of the trophic factors were determined by quantitative real-time polymerase chain reaction. Here, we report significant down regulation in the gene expression of trophic factors for BDNF, FGF2 and IGF1. BDNF mRNA levels were found to be reduced by 6.8-fold in the ALS-CSF injected group compared to control groups. The levels of IGF1 and FGF2 mRNA were also decreased by 3.91- and 2.13-fold, respectively, in the ALS group. We further found that exogenous supplementation of BDNF considerably reduced the aberrant phosphorylation of neurofilaments, complementing our earlier findings of restored expression of voltage gated sodium channel. Reduced expression of trophic factors indicates an altered microenvironment of the motor neurons and could possibly be one of the contributing factors in the degeneration process.

  13. Chronic systemic administration of salmeterol to rats promotes pulmonary β2-adrenoceptor desensitization and down-regulation of Gsα

    PubMed Central

    Finney, Paul A; Donnelly, Louise E; Belvisi, Maria G; Chuang, Tsu-Tshen; Birrell, Mark; Harris, Andrew; Mak, Judith C W; Scorer, Carol; Barnes, Peter J; Adcock, Ian M; Giembycz, Mark A

    2001-01-01

    The aim of the present study was to examine the effects of chronic infusion of the long-acting agonist salmeterol on pulmonary β2-adrenoceptor function in Sprague-Dawley rats in vivo and to elucidate the molecular basis of any altered state. Systemic administration of rats with salmeterol for 7 days compromised the ability of salmeterol and prostaglandin E2 (PGE2), given acutely by the intravenous route, to protect against ACh-induced bronchoconstriction when compared to rats treated identically with vehicle. β1- and β2-adrenoceptor density was significantly reduced in lung membranes harvested from salmeterol-treated animals, which was associated with impaired salmeterol- and PGE2-induced cyclic AMP accumulation ex vivo. Three variants of Gsα that migrated as 42, 44 and 52 kDa peptides on SDS polyacrylamide gels were detected in lung membranes prepared from both groups of rats but the intensity of each isoform was markedly reduced in rats that received salmeterol. The activity of cytosolic, but not membrane-associated, G-protein receptor-coupled kinase was elevated in the lung of salmeterol-treated rats when compared to vehicle-treated animals. The ability of salmeterol, administered systemically, to protect the airways of untreated rats against ACh-induced bronchoconstriction was short-acting (toff ∼45 min), which contrasts with its long-acting nature when given to asthmatic subjects by inhalation. These results indicate that chronic treatment of rats with salmeterol results in heterologous desensitization of pulmonary Gs-coupled receptors. In light of previous data obtained in rats treated chronically with salbutamol, we propose that a primary mechanism responsible for this effect is a reduction in membrane-associated Gsα. The short-acting nature of salmeterol, when administered systemically, and the reduction in β-adrenoceptor number may be due to metabolism to a biologically-active, short-acting and non-selective β-adrenoceptor agonist. PMID

  14. Reported infections after human tissue transplantation before and after new Food and Drug Administration (FDA) regulations, United States, 2001 through June, 2010.

    PubMed

    Mallick, Tarun K; Mosquera, Alexis; Zinderman, Craig E; St Martin, Laura; Wise, Robert P

    2012-06-01

    Processors distributed about 1.5 million human tissue allografts in the U.S. in 2007. The potential for transmitting infections through allografts concerns clinicians and patients. In 2005, FDA implemented Current Good Tissue Practice (CGTP) rules requiring tissue establishments to report to FDA certain serious infections after allograft transplantations. We describe infection reports following tissue transplants received by FDA from 2005 through June, 2010, and compare reporting before and after implementation of CGTP rules. We identified reports received by FDA from January 2001 through June, 2010, for infections in human tissue recipients, examining the reports by tissue type, organism, time to onset, severity, and reporter characteristics. Among 562 reports, 83 (20.8/year) were received from 2001-2004, before the CGTP rules, 43 in the 2005 transition year, and 436 (96.9/year) from 2006 through June, 2010, after the rules. Tissue processors accounted for 84.2% of reports submitted after the rules, compared to 26.5% previously. Bacterial infections were the most commonly reported organisms before (64.6%) and after (62.2%) the new rules. Afterward, 2.5% (11) of reports described deaths, and 33.7% (147) involved hospitalizations. Before the rules, 13% (11) described deaths, and another 72% involved hospitalizations. Reports received by the FDA quadrupled since 2005, suggesting that CGTP regulations have contributed to increased reporting and improved tissue safety surveillance. However, these data do not confirm that the reported infections were caused by suspect tissues; most reports may represent routine post-surgical infections not actually due to allografts.

  15. Short and long access to cocaine self-administration activates tyrosine phosphatase STEP and attenuates GluN expression but differentially regulates GluA expression in the prefrontal cortex

    PubMed Central

    Sun, Wei-Lun; Zelek-Molik, Agnieszka; McGinty, Jacqueline F.

    2013-01-01

    Rationale Dephosphorylation of extracellular signal-regulated kinase (ERK) and cyclic AMP response element binding protein (CREB) in the dorsomedial prefrontal cortex (dmPFC) at the end of short access (ShA) cocaine self-administration is implicated in cocaine-seeking. However, what receptors and phosphatases mediate this effect and whether ERK/CREB and related phospho-proteins in the dmPFC react similarly during early withdrawal from long access (LgA) cocaine self-administration are unknown. Objectives The effects of ShA vs. LgA cocaine self-administration on the phosphorylation of protein phosphatase 2A (PP2A) and striatal-enriched protein tyrosine phosphatase (STEP), as well as GluN and GluA receptor subtype expression in the dmPFC during early withdrawal were compared. Methods Rats self-administered cocaine or received saline during 2-hr or 6-hr daily sessions for 10-11 days. Two hr after the final session, the dmPFC was dissected out and processed for immunoblotting. Results Similar to previous findings after ShA cocaine, phospho-ERK and phospho-CREB in the dmPFC were decreased after LgA cocaine. Cocaine elevated phospho-PP2A (de-activation) and decreased phosphor-STEP (activation) in both ShA and LgA cocaine rats. GluN1, GluN2B and phospho-GluN2B Tyr1472 in the dmPFC were decreased after ShA and LgA cocaine. Further, a significant reduction of GluA2, GluA1 and phospho-GluA1 Ser845 was found only in LgA rats. Conclusions Activation of phospho-STEP may underlie ERK and CREB dephosphorylation in the dmPFC as well as internalization and degradation of GluN complexes during early withdrawal from both ShA and LgA cocaine self-administration whereas differential alteration of AMPA receptor subunits after ShA and LgA cocaine self-administration depends on cocaine intake. PMID:23624776

  16. 7 CFR 735.2 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Administrator, Commodity Operations, Farm Service Agency, United States Department of Agriculture, STOP 0550... REGULATIONS FOR WAREHOUSES REGULATIONS FOR THE UNITED STATES WAREHOUSE ACT General Provisions § 735.2... 7 Agriculture 7 2012-01-01 2012-01-01 false Administration. 735.2 Section 735.2...

  17. 7 CFR 735.2 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Administrator, Commodity Operations, Farm Service Agency, United States Department of Agriculture, STOP 0550... REGULATIONS FOR WAREHOUSES REGULATIONS FOR THE UNITED STATES WAREHOUSE ACT General Provisions § 735.2... 7 Agriculture 7 2014-01-01 2014-01-01 false Administration. 735.2 Section 735.2...

  18. 48 CFR 1253.204 - Administrative matters.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 5 2013-10-01 2013-10-01 false Administrative matters. 1253.204 Section 1253.204 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION CLAUSES AND FORMS FORMS Prescription of Forms 1253.204 Administrative matters. The following forms...

  19. 48 CFR 1253.204 - Administrative matters.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administrative matters. 1253.204 Section 1253.204 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION CLAUSES AND FORMS FORMS Prescription of Forms 1253.204 Administrative matters. The following forms...

  20. 48 CFR 1253.204 - Administrative matters.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Administrative matters. 1253.204 Section 1253.204 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION CLAUSES AND FORMS FORMS Prescription of Forms 1253.204 Administrative matters. The following forms...

  1. 48 CFR 1253.204 - Administrative matters.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 5 2012-10-01 2012-10-01 false Administrative matters. 1253.204 Section 1253.204 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION CLAUSES AND FORMS FORMS Prescription of Forms 1253.204 Administrative matters. The following forms...

  2. 48 CFR 1253.204 - Administrative matters.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 5 2014-10-01 2014-10-01 false Administrative matters. 1253.204 Section 1253.204 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION CLAUSES AND FORMS FORMS Prescription of Forms 1253.204 Administrative matters. The following forms...

  3. 7 CFR 253.11 - Administrative funds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM FOR HOUSEHOLDS ON INDIAN RESERVATIONS § 253.11 Administrative funds. (a) Allocation of...

  4. 7 CFR 253.11 - Administrative funds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION ADMINISTRATION OF THE FOOD DISTRIBUTION PROGRAM FOR HOUSEHOLDS ON INDIAN RESERVATIONS § 253.11 Administrative funds. (a) Allocation of...

  5. 7 CFR 1491.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Administration. 1491.2 Section 1491.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... § 1491.2 Administration. (a) The regulations in this part shall be administered under the...

  6. 7 CFR 1491.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1491.2 Section 1491.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... § 1491.2 Administration. (a) The regulations in this part shall be administered under the...

  7. 48 CFR 828.106 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Administration. 828.106 Section 828.106 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 828.106 Administration....

  8. 48 CFR 1328.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1328.106 Section 1328.106 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 1328.106 Administration....

  9. 7 CFR 735.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Administration. 735.2 Section 735.2 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. (a) FSA will administer all provisions and activities regulated under the Act under the...

  10. 7 CFR 1470.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Administration. 1470.2 Section 1470.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF....2 Administration. (a) The regulations in this part will be administered under the...

  11. 7 CFR 1434.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Administration. 1434.2 Section 1434.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... FOR HONEY § 1434.2 Administration. (a) The regulations of this part shall be administered under...

  12. 48 CFR 428.106 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false Administration. 428.106 Section 428.106 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 428.106 Administration....

  13. 7 CFR 735.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 735.2 Section 735.2 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. (a) FSA will administer all provisions and activities regulated under the Act under the...

  14. 48 CFR 1328.106 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Administration. 1328.106 Section 1328.106 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 1328.106 Administration....

  15. 7 CFR 1434.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1434.2 Section 1434.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... FOR HONEY § 1434.2 Administration. (a) The regulations of this part shall be administered under...

  16. 48 CFR 2828.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Administration. 2828.106 Section 2828.106 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE General Contracting Requirements BONDS AND INSURANCE Bonds 2828.106 Administration....

  17. 7 CFR 735.400 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Administration. 735.400 Section 735.400 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. This subpart sets forth the regulations under which DACO may authorize one or more...

  18. 48 CFR 828.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 828.106 Section 828.106 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 828.106 Administration....

  19. 48 CFR 1228.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1228.106 Section 1228.106 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 1228.106 Administration....

  20. 48 CFR 1228.106 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 5 2011-10-01 2011-10-01 false Administration. 1228.106 Section 1228.106 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 1228.106 Administration....

  1. 7 CFR 625.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 625.3 Section 625.3 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES HEALTHY FORESTS RESERVE PROGRAM § 625.3 Administration. (a) The regulations...

  2. 48 CFR 428.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Administration. 428.106 Section 428.106 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds and Other Financial Protections 428.106 Administration....

  3. 7 CFR 1469.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1469.2 Section 1469.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. (a) The regulations in this part will be administered under the general supervision and...

  4. 7 CFR 1400.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Administration. 1400.2 Section 1400.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.2 Administration. (a) The regulations...

  5. 7 CFR 1469.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Administration. 1469.2 Section 1469.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... Administration. (a) The regulations in this part will be administered under the general supervision and...

  6. 7 CFR 1400.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1400.2 Section 1400.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... SUBSEQUENT CROP, PROGRAM, OR FISCAL YEARS General Provisions § 1400.2 Administration. (a) The regulations...

  7. 7 CFR 735.400 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Administration. 735.400 Section 735.400 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. This subpart sets forth the regulations under which DACO may authorize one or more...

  8. 48 CFR 2828.106 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 6 2011-10-01 2011-10-01 false Administration. 2828.106 Section 2828.106 Federal Acquisition Regulations System DEPARTMENT OF JUSTICE GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 2828.106 Administration....

  9. 48 CFR 1028.106 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Administration. 1028.106 Section 1028.106 Federal Acquisition Regulations System DEPARTMENT OF THE TREASURY GENERAL CONTRACTING REQUIREMENTS BONDS AND INSURANCE Bonds 1028.106 Administration....

  10. 29 CFR 1903.21 - State administration.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false State administration. 1903.21 Section 1903.21 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR INSPECTIONS, CITATIONS AND PROPOSED PENALTIES § 1903.21 State administration. Nothing in this part 1903...

  11. 24 CFR 594.25 - Project administration.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Project administration. 594.25 Section 594.25 Housing and Urban Development Regulations Relating to Housing and Urban Development... Grant Amounts § 594.25 Project administration. Project administration will be governed by the terms...

  12. 48 CFR 30.607 - Subcontract administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CONTRACTING REQUIREMENTS COST ACCOUNTING STANDARDS ADMINISTRATION CAS Administration 30.607 Subcontract administration. When a negotiated CAS price adjustment or a determination of noncompliance is required at the... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Subcontract...

  13. 45 CFR 1703.501 - Administrative Review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Administrative Review. 1703.501 Section 1703.501 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE GOVERNMENT IN THE SUNSHINE ACT Administrative Review § 1703.501 Administrative Review....

  14. 7 CFR 1465.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Administration. 1465.2 Section 1465.2 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT CORPORATION, DEPARTMENT OF... § 1465.2 Administration. (a) Administration and implementation of AMA's conservation provisions for...

  15. 7 CFR 633.3 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Administration. 633.3 Section 633.3 Agriculture... AGRICULTURE LONG TERM CONTRACTING WATER BANK PROGRAM § 633.3 Administration. (a) The regulations in this part... administration and related policy matters. No determination by the State Technical Committee shall compel...

  16. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....

  17. 7 CFR 633.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 633.3 Section 633.3 Agriculture... AGRICULTURE LONG TERM CONTRACTING WATER BANK PROGRAM § 633.3 Administration. (a) The regulations in this part... administration and related policy matters. No determination by the State Technical Committee shall compel...

  18. 7 CFR 652.3 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Administration. 652.3 Section 652.3 Agriculture... AGRICULTURE SUPPORT ACTIVITIES TECHNICAL SERVICE PROVIDER ASSISTANCE General Provisions § 652.3 Administration... part. (b) The Chief of NRCS will direct and supervise the administration of the regulations in...

  19. 7 CFR 760.1101 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 7 2011-01-01 2011-01-01 false Administration. 760.1101 Section 760.1101 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE... Administration. (a) This program is administered under the general supervision of the Administrator, Farm...

  20. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....