Science.gov

Sample records for administration key results

  1. Key Obama officials leave administration

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-01-01

    Secretary of the Interior Ken Salazar is one of the latest members of the Obama administration to announce that he is leaving his position near the start of President Obama's second term in office. Salazar, who has served as interior secretary since January 2009, intends to leave the department by the end of March, the department noted on 16 January. Salazar joins a number of other key officials who are planning to leave the administration. They include Environmental Protection Agency administrator Lisa Jackson, National Oceanic and Atmospheric Administration administrator Jane Lubchenco, and U.S. Geological Survey director Marcia McNutt.

  2. Education key to helping administrators accept ORYX.

    PubMed

    2000-07-01

    ORYX may not be popular with many hospitals, but it can make a difference in quality. Educating everyone in the hospital--from the CEO to medical staff to department heads--can result in changes that will benefit both patients and employees. When hospitals read the ORYX measurements and see how well they're doing, it's uplifting for everyone. When they see a problem, it's a chance to make a significant improvement.

  3. Creating a Welcoming Environment: 4 Key Tips for Administrators

    ERIC Educational Resources Information Center

    Region IX Equity Assistance Center at WestEd, 2015

    2015-01-01

    Family-school partnerships boost student achievement and school improvement from preschool through high school. With family engagement as a priority and requirement for Local Control Accountability Plans (LCAPs), family engagement in schools matters more than ever. Four key tips for administrators for creating a welcoming environment are shared…

  4. New Security Results on Encrypted Key Exchange

    SciTech Connect

    Bresson, Emmanuel; Chevassut, Olivier; Pointcheval, David

    2003-12-15

    Schemes for encrypted key exchange are designed to provide two entities communicating over a public network, and sharing a (short) password only, with a session key to be used to achieve data integrity and/or message confidentiality. An example of a very efficient and ''elegant'' scheme for encrypted key exchange considered for standardization by the IEEE P1363 Standard working group is AuthA. This scheme was conjectured secure when the symmetric-encryption primitive is instantiated via either a cipher that closely behaves like an ''ideal cipher,'' or a mask generation function that is the product of the message with a hash of the password. While the security of this scheme in the former case has been recently proven, the latter case was still an open problem. For the first time we prove in this paper that this scheme is secure under the assumptions that the hash function closely behaves like a random oracle and that the computational Diffie-Hellman problem is difficult. Furthermore, since Denial-of-Service (DoS) attacks have become a common threat we enhance AuthA with a mechanism to protect against them.

  5. Quasi-normal frequencies: key analytic results

    NASA Astrophysics Data System (ADS)

    Boonserm, Petarpa; Visser, Matt

    2011-03-01

    The study of exact quasi-normal modes [QNMs], and their associated quasi-normal frequencies [QNFs], has had a long and convoluted history — replete with many rediscoveries of previously known results. In this article we shall collect and survey a number of known analytic results, and develop several new analytic results — specifically we shall provide several new QNF results and estimates, in a form amenable for comparison with the extant literature. Apart from their intrinsic interest, these exact and approximate results serve as a backdrop and a consistency check on ongoing efforts to find general model-independent estimates for QNFs, and general model-independent bounds on transmission probabilities. Our calculations also provide yet another physics application of the Lambert W function. These ideas have relevance to fields as diverse as black hole physics, (where they are related to the damped oscillations of astrophysical black holes, to greybody factors for the Hawking radiation, and to more speculative state-counting models for the Bekenstein entropy), to quantum field theory (where they are related to Casimir energies in unbounded systems), through to condensed matter physics, (where one may literally be interested in an electron tunnelling through a physical barrier).

  6. Persuasive Strategies for School Administrators: A Key to School Effectiveness.

    ERIC Educational Resources Information Center

    Rakes, Thomas A.; Cox, Glenda C.

    1994-01-01

    To gain others' consistent and active cooperation, administrators should convince faculty and staff that a task should be done. An administrator who uses persuasion communicates a degree of respect that strengthens the supervisor-subordinate relationship. Compliance-gaining strategies may be classified according to expectancies and consequences,…

  7. Key results from SB8 simulant flowsheet studies

    SciTech Connect

    Koopman, D. C.

    2013-04-26

    Key technically reviewed results are presented here in support of the Defense Waste Processing Facility (DWPF) acceptance of Sludge Batch 8 (SB8). This report summarizes results from simulant flowsheet studies of the DWPF Chemical Process Cell (CPC). Results include: Hydrogen generation rate for the Sludge Receipt and Adjustment Tank (SRAT) and Slurry Mix Evaporator (SME) cycles of the CPC on a 6,000 gallon basis; Volume percent of nitrous oxide, N2O, produced during the SRAT cycle; Ammonium ion concentrations recovered from the SRAT and SME off-gas; and, Dried weight percent solids (insoluble, soluble, and total) measurements and density.

  8. Key Questions on the Obama Administration's 2014 Education Budget Request. Issue Brief

    ERIC Educational Resources Information Center

    New America Foundation, 2013

    2013-01-01

    President Obama sent his fiscal year 2014 budget request to Congress on April 10, 2013. The New America Foundation's Education Policy Program released this subsequent issue brief, "Key Questions on the Obama Administration's 2014 Budget Request." Obama's budget request totals $71.2 billion in appropriations funding for the U.S.…

  9. 77 FR 42273 - Solid Urea From the Russian Federation: Preliminary Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... International Trade Administration Solid Urea From the Russian Federation: Preliminary Results of Antidumping Duty Administrative Review AGENCY: Import Administration, International Trade Administration..., International Trade Administration, U.S. Department of Commerce, 14th Street and Constitution Avenue...

  10. 78 FR 42497 - Certain Frozen Warmwater Shrimp From Thailand: Final Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-16

    ... International Trade Administration Certain Frozen Warmwater Shrimp From Thailand: Final Results of Antidumping... AGENCY: Import Administration, International Trade Administration, Department of Commerce. SUMMARY: On..., Import Administration, International Trade Administration, U.S. Department of Commerce, 14th Street...

  11. Key uncertainties in climate change policy: Results from ICAM-2

    SciTech Connect

    Dowlatabadi, H.; Kandlikar, M.

    1995-12-31

    A critical aspect of climate change decision-making is uncertainties in current understanding of the socioeconomic, climatic and biogeochemical processes involved. Decision-making processes are much better informed if these uncertainties are characterized and their implications understood. Quantitative analysis of these uncertainties serve to: inform decision makers about the likely outcome of policy initiatives; and help set priorities for research so that outcome ambiguities faced by the decision-makers are reduced. A family of integrated assessment models of climate change have been developed at Carnegie Mellon. These models are distinguished from other integrated assessment efforts in that they were designed from the outset to characterize and propagate parameter, model, value, and decision-rule uncertainties. The most recent of these models is ICAM 2.0. This model includes demographics, economic activities, emissions, atmospheric chemistry, climate change, sea level rise and other impact modules and the numerous associated feedbacks. The model has over 700 objects of which over 1/3 are uncertain. These have been grouped into seven different classes of uncertain items. The impact of uncertainties in each of these items can be considered individually or in combinations with the others. In this paper we demonstrate the relative contribution of various sources of uncertainty to different outcomes in the model. The analysis shows that climatic uncertainties are most important, followed by uncertainties in damage calculations, economic uncertainties and direct aerosol forcing uncertainties. Extreme uncertainties in indirect aerosol forcing and behavioral response to climate change (adaptation) were characterized by using bounding analyses; the results suggest that these extreme uncertainties can dominate the choice of policy outcomes.

  12. 70 FR 36563 - Honey from Argentina: Final Results of Countervailing Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2005-06-24

    ... International Trade Administration Honey from Argentina: Final Results of Countervailing Duty Administrative... its preliminary results of administrative review of the countervailing duty order on honey from Argentina for the period January 1, 2003, through December 31, 2003. Honey from Argentina:...

  13. 69 FR 29518 - Honey from Argentina: Final Results of Countervailing Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2004-05-24

    ... International Trade Administration Honey from Argentina: Final Results of Countervailing Duty Administrative... its preliminary results of administrative review of the countervailing duty order on honey from... requests for an administrative review of the countervailing duty (CVD) order on honey from Argentina...

  14. Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants.

    PubMed Central

    Critchley, E M; Vakil, S D; Hayward, H W; Owen, V M

    1976-01-01

    In a study of chronic epileptics in a residential centre we recorded a 56% incidence of Dupuytren's disease. The lesions were usually bilateral and symmetrical and frequently associated with knuckle pads and plantar nodules. There was no direct relationship between Dupuytren's disease and frozen shoulder. Dupuytren's disease was seen equally in those with idiopathic or symptomatic epilepsy. The incidence increased with the duration of epilepsy and is probably a sequel to long-term administration of phenobarbitone. Reasons are given for presuming that the association between Dupuytren's disease and antiepileptic therapy is mediated through the peripheral stimulation of tissue growth factors and not through the central release of growth hormone or through alterations in liver metabolism. PMID:932769

  15. Regional economic impacts of changes in electricity rates resulting from Western Area Power Administration`s power marketing alternatives

    SciTech Connect

    Allison, T.; Griffes, P.; Edwards, B.K.

    1995-03-01

    This technical memorandum describes an analysis of regional economic impacts resulting from changes in retail electricity rates due to six power marketing programs proposed by Western Area Power Administration (Western). Regional economic impacts of changes in rates are estimated in terms of five key regional economic variables: population, gross regional product, disposable income, employment, and household income. The REMI (Regional Impact Models, Inc.) and IMPLAN (Impact Analysis for Planning) models simulate economic impacts in nine subregions in the area in which Western power is sold for the years 1993, 2000, and 2008. Estimates show that impacts on aggregate economic activity in any of the subregions or years would be minimal for three reasons. First, the utilities that buy power from Western sell only a relatively small proportion of the total electricity sold in any of the subregions. Second, reliance of Western customers on Western power is fairly low in each subregion. Finally, electricity is not a significant input cost for any industry or for households in any subregion.

  16. 75 FR 56989 - Magnesium Metal From the Russian Federation: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... International Trade Administration Magnesium Metal From the Russian Federation: Final Results of Antidumping... results of the administrative review of the antidumping duty order on magnesium metal from the Russian... preliminary results of the administrative review of the antidumping duty order on magnesium metal from...

  17. Administrator & Teacher Decision Module. Module I. Telecommunication Aids in Learning the Keys (TALK).

    ERIC Educational Resources Information Center

    Canipe, Stephen

    This module presents information to administrators and teachers planning to use telecommunications in the business and office curriculum in grades 9-12. It accompanies three modules designed for use in three courses in which a unit on telecommunications can be taught. The module addresses four major needs. The first section discusses required…

  18. Nursing Faculty Shortage Nurses' Perceptions as a Key to Administrative Solutions

    ERIC Educational Resources Information Center

    Klocke, Evelyn M.

    2009-01-01

    The nursing faculty shortage is well documented. Higher education administrators turn away qualified student applicants because of the lack of qualified nursing faculty. Furthermore, they find recruitment and retention of qualified nursing faculty a challenge. The purpose of this study was to explore perceptions of the nursing faculty role, causes…

  19. 77 FR 36253 - Honey From Argentina: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-18

    ... International Trade Administration Honey From Argentina: Final Results of Antidumping Duty Administrative Review... 2009-2010 administrative review of the antidumping duty order on honey from Argentina.\\1\\ The review... in the ``Final Results of Review'' section of this notice. \\1\\ See Honey From Argentina:...

  20. 75 FR 39663 - Stainless Steel Bar From Brazil: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... International Trade Administration Stainless Steel Bar From Brazil: Final Results of Antidumping Duty... of its administrative review of the antidumping duty order on certain stainless steel bar from Brazil... results of its administrative review of the antidumping duty order on certain stainless steel bar...

  1. 75 FR 38076 - Carbazole Violet Pigment 23 from India: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... International Trade Administration Carbazole Violet Pigment 23 from India: Final Results of Antidumping Duty... administrative review of the antidumping duty order on carbazole violet pigment 23 (CVP 23) from India. The... Pigment 23 from India: Preliminary Results of Antidumping Duty Administrative Review, 74 FR...

  2. 76 FR 29192 - Honey From Argentina: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... International Trade Administration Honey From Argentina: Final Results of Antidumping Duty Administrative Review... 2008-2009 administrative review of the antidumping duty order on honey from Argentina. See Honey From...., Patagonik S.A., and TransHoney S.A.; all three exporters of honey from Argentina to the United States...

  3. 76 FR 2655 - Honey From Argentina: Preliminary Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... International Trade Administration Honey From Argentina: Preliminary Results of Antidumping Duty Administrative... conducting an administrative review of the antidumping duty order on honey from Argentina. The review covers... determine that sales of honey from Argentina have not been made below normal value (NV) by TransHoney...

  4. 69 FR 621 - Honey From Argentina: Preliminary Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2004-01-06

    ... International Trade Administration Honey From Argentina: Preliminary Results of Antidumping Duty Administrative... announcing the initiation of the administrative review of the antidumping duty order on honey from Argentina... sales of honey from Argentina have been made below the normal value (NV) in the cases of Nexco S.A....

  5. 78 FR 38938 - Polyester Staple Fiber From Taiwan: Final Results of Antidumping Duty Administrative Review; 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-28

    ... International Trade Administration Polyester Staple Fiber From Taiwan: Final Results of Antidumping Duty... results of the administrative review of the antidumping duty order on polyester staple fiber (PSF) from... Preliminary Results. None were received. \\1\\ See Polyester Staple Fiber From Taiwan: Preliminary Results...

  6. 75 FR 23674 - Honey from Argentina: Final Results of Antidumping Duty Administrative Review and Determination...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-04

    ... International Trade Administration A-357-812 Honey from Argentina: Final Results of Antidumping Duty... antidumping duty order on honey from Argentina. See Honey from Argentina: Preliminary Results of Antidumping... preliminary results of the administrative review of the antidumping duty order on honey from Argentina for...

  7. 78 FR 23220 - Lightweight Thermal Paper From Germany: Final Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... International Trade Administration Lightweight Thermal Paper From Germany: Final Results of Antidumping Duty... preliminary results of the administrative review of the antidumping duty order on lightweight thermal paper... in the section entitled ``Final Results of Review.'' \\1\\ See Lightweight Thermal Paper from...

  8. 76 FR 1599 - Stainless Steel Bar From Brazil: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... International Trade Administration Stainless Steel Bar From Brazil: Final Results of Antidumping Duty... results of its administrative review of the antidumping duty order on stainless steel bar from Brazil. The... stainless steel bar (SSB) from Brazil. See Stainless Steel Bar From Brazil: Preliminary Results...

  9. 78 FR 12034 - Certain Preserved Mushrooms From India: Final Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... International Trade Administration Certain Preserved Mushrooms From India: Final Results of Antidumping Duty... preliminary results of the administrative review of the antidumping duty order on certain preserved mushrooms... the antidumping duty order on certain preserved mushrooms (mushrooms) from India.\\1\\ We...

  10. 77 FR 39467 - Stainless Steel Bar From India: Final Results of the Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... International Trade Administration Stainless Steel Bar From India: Final Results of the Antidumping Duty... the administrative review of the antidumping duty order on stainless steel bar from India. The review..., 2012, the Department published Stainless Steel Bar From India: Preliminary Results and...

  11. 75 FR 33243 - Carbazole Violet Pigment 23 From India: Final Results of Countervailing Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... International Trade Administration Carbazole Violet Pigment 23 From India: Final Results of Countervailing Duty... India for the period January 1, 2007, through December 31, 2007. See Carbazole Violet Pigment 23 from India: Preliminary Results of Countervailing Duty Administrative Review, 75 FR 977 (January 7,...

  12. 78 FR 72633 - Chlorinated Isocyanurates From Spain: Final Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... International Trade Administration Chlorinated Isocyanurates From Spain: Final Results of Antidumping Duty... chlorinated isocyanurates (chlorinated isos) from Spain.\\1\\ The period of review (``POR'') is June 1, 2011... notice. \\1\\ See Chlorinated Isocyanurates from Spain: Preliminary Results of the Antidumping...

  13. Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2006

    ERIC Educational Resources Information Center

    Johnston, Lloyd D., O'Malley, Patrick M.; Bachman, Jerald G.; Schulenberg, John E.

    2007-01-01

    This report provides a summary of drug use trends from a survey of nearly 50,000 eighth-, tenth-, and twelfth- grade students nationwide. It also includes perceived risk, personal disapproval, and perceived availability of each drug by this group. A synopsis of the methods used in the study and an overview of the key results from the 2006 survey…

  14. Key Performance Indicators: From Promise to Payoff. The Productivity for Results Series No. 2

    ERIC Educational Resources Information Center

    Casserly, Michael; Eugene, Michael

    2014-01-01

    This paper draws upon the expertise of two leading educators, Michael Casserly, director of the Council of the Great City Schools, and Michael Eugene, chief operating officer of the Orange County Public Schools in Florida. They outline a set of key performance indicators that some urban districts use to benchmark the results of their operating…

  15. 78 FR 4383 - Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... International Trade Administration Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty... the antidumping duty order on stainless steel bar (SSB) from Brazil. The period of review (POR) is... Antidumping Duty Administrative Review: Stainless Steel Bar from Brazil'' dated concurrently with this...

  16. 78 FR 17637 - Polyester Staple Fiber From Taiwan: Preliminary Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... International Trade Administration Polyester Staple Fiber From Taiwan: Preliminary Results of Antidumping Duty... the antidumping duty order on polyester staple fiber (PSF) from Taiwan. The period of review (POR) is... Antidumping Duty Administrative Review: Polyester Staple Fiber from Taiwan'' dated concurrently with...

  17. 76 FR 57955 - Certain Polyester Staple Fiber From Taiwan: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... International Trade Administration Certain Polyester Staple Fiber From Taiwan: Final Results of Antidumping Duty... administrative review of the antidumping duty order on certain polyester staple fiber from Taiwan. The period of... certain polyester staple fiber from Taiwan. See Certain Polyester Staple Fiber From Taiwan:...

  18. 75 FR 43921 - Certain Polyester Staple Fiber From Taiwan: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ... International Trade Administration Certain Polyester Staple Fiber From Taiwan: Final Results of Antidumping Duty... administrative review of the antidumping duty order on certain polyester staple fiber from Taiwan. The period of... review of the antidumping duty order on certain polyester staple fiber (PSF) from Taiwan. See...

  19. 77 FR 54561 - Certain Polyester Staple Fiber From Taiwan: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ...] Certain Polyester Staple Fiber From Taiwan: Final Results of Antidumping Duty Administrative Review AGENCY... antidumping duty order on certain polyester staple fiber from Taiwan. The period of review is May 1, 2010... administrative review of the antidumping duty order on certain polyester staple fiber from Taiwan. See...

  20. 77 FR 40848 - Certain Frozen Warmwater Shrimp From India: Final Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-11

    ... International Trade Administration Certain Frozen Warmwater Shrimp From India: Final Results of Antidumping Duty... frozen warmwater shrimp (shrimp) from India. The period of review (POR) is February 1, 2010, through... administrative review of the antidumping duty order on shrimp from India.\\1\\ \\1\\ See Certain Frozen...

  1. 76 FR 66690 - Solid Urea From the Russian Federation: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-27

    ... International Trade Administration Solid Urea From the Russian Federation: Final Results of Antidumping Duty... of the administrative review of the antidumping duty order on solid urea from the Russian Federation. The solid urea subject to this review was produced and exported by MCC EuroChem (EuroChem). The...

  2. 77 FR 1458 - Honey From Argentina: Preliminary Results of Antidumping Duty Administrative Review and Partial...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... International Trade Administration Honey From Argentina: Preliminary Results of Antidumping Duty Administrative... antidumping duty order on honey from Argentina. The review covers imports of subject merchandise from nine... determine that sales of honey from Argentina have not been made below normal value (NV) by...

  3. 69 FR 30283 - Honey From Argentina: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2004-05-27

    ... International Trade Administration Honey From Argentina: Final Results of Antidumping Duty Administrative Review... order on honey from Argentina produced and/or exported by Asociacion de Cooperativas Argentinas (``ACA''), HoneyMax S.A. (``HoneyMax''), Nexco S.A. (``Nexco''), Seylinco S.A. (``Seylinco''), and TransHoney...

  4. 76 FR 56396 - Magnesium Metal from the Russian Federation: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... International Trade Administration Magnesium Metal from the Russian Federation: Final Results of Antidumping... of the administrative review of the antidumping duty order on magnesium metal from the Russian... metal from the Russian Federation. See Magnesium Metal From the Russian Federation: Preliminary...

  5. 78 FR 67335 - Solid Urea From the Russian Federation: Final Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... International Trade Administration Solid Urea From the Russian Federation: Final Results of Antidumping Duty... duty order on solid urea from the Russian Federation (Russia). For the final results, we continue to... solid urea from Russia.\\1\\ We invited interested parties to comment on the Preliminary Results....

  6. Impacts on irrigated agriculture of changes in electricity costs resulting from Western Area Power Administration`s power marketing alternatives

    SciTech Connect

    Edwards, B.K.; Flaim, S.J.; Howitt, R.E.; Palmer, S.C.

    1995-03-01

    Irrigation is a major factor in the growth of US agricultural productivity, especially in western states, which account for more than 85% of the nation`s irrigated acreage. In some of these states, almost all cropland is irrigated, and nearly 50% of the irrigation is done with electrically powered pumps. Therefore, even small increases in the cost of electricity could have a disproportionate impact on irrigated agriculture. This technical memorandum examines the impacts that could result from proposed changes in the power marketing programs of the Western Area Power Administration`s Salt Lake City Area Office. The changes could increase the cost of power to all Western customers, including rural municipalities and irrigation districts that rely on inexpensive federal power to pump water. The impacts are assessed by translating changes in Western`s wholesale power rate into changes in the cost of pumping water as an input for agricultural production. Farmers can adapt to higher electricity prices in many ways, such as (1) using different pumping fuels, (2) adding workers and increasing management to irrigate more efficiently, and (3) growing more drought-tolerant crops. This study projects several responses, including using less groundwater and planting fewer waterintensive crops. The study finds that when dependence on Western`s power is high, the cost of power can have a major effect on energy use, agricultural practices, and the distribution of planted acreage. The biggest percentage changes in farm income would occur (1) in Nevada and Utah (however, all projected changes are less than 2% of the baseline) and (2) under the marketing alternatives that represent the lowest capacity and energy offer considered in Western`s Electric Power Marketing Environmental Impact Statement. The aggregate impact on farm incomes and the value of total farm production would be much smaller than that suggested by the changes in water use and planted acreage.

  7. 75 FR 18794 - Certain Orange Juice From Brazil: Preliminary Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-13

    .... Comercio, Industria, and Agricultura (Fischer) and Sucocitrico Cutrale, S.A. (Cutrale). In Cutrale's.... Comercio, Industria, e Agricultura for the Preliminary Results in the 08-09 Antidumping Duty Administrative... Results--Fischer S.A. Comercio, Industria and Agricultura.'' 2. Test of Comparison Market Sales Prices...

  8. 78 FR 9670 - Polyethylene Terephthalate Film, Sheet, and Strip From India: Final Results of Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... International Trade Administration Polyethylene Terephthalate Film, Sheet, and Strip From India: Final Results... order on polyethylene terephthalate film (PET Film) from India.\\1\\ This review covers three respondents... the ``Final Results of Review'' section below. \\1\\ See Polyethylene Terephthalate Film, Sheet,...

  9. 78 FR 22845 - Certain Lined Paper Products From India: Final Results of Countervailing Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... International Trade Administration Certain Lined Paper Products From India: Final Results of Countervailing Duty... countervailing duty (CVD) order on certain lined paper products from India for the January 1, 2010, through...'' section. \\1\\ See Certain Lined Paper Products From India: Preliminary Results of Countervailing...

  10. 25 CFR 170.618 - Can a tribe keep savings resulting from project administration?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Can a tribe keep savings resulting from project... Agreements Under Isdeaa § 170.618 Can a tribe keep savings resulting from project administration? When actual.... (See 25 U.S.C. 450e-2.)...

  11. Errors in the Administration Technique of Insulin Pen Devices: A Result of Insufficient Education.

    PubMed

    Truong, Teresa H; Nguyen, Trang T; Armor, Becky L; Farley, Jamie R

    2017-04-01

    Insulin is a high-alert medication in both inpatient and outpatient settings. Insulin can cause significant harm when administered in error. Despite advancements in insulin pen technology, errors in the administration technique remain an issue. Although various factors can contribute to administration errors, lack of education on how to operate these devices is one of the most common reasons they occur. As such, the mechanical technique used by the patient needs to be continually assessed in order to reinforce education where needed. We describe three unique patient cases that depict incorrect administration techniques when using pen devices and the consequences that could have resulted from these errors. These cases involve the use of a syringe instead of a pen needle, injecting without removing the inner cap, and dialing the pen back down instead of pushing the plunger. Although pen devices are relatively simple to use, this article reinforces the need for continual assessment of and education about insulin administration. The teach-back method is an approach that can be used to assess a patient's technique and re-educate them at every available opportunity to reduce the risk of administration errors, which can result in complications and hospitalizations.

  12. 76 FR 19315 - Certain Orange Juice From Brazil: Preliminary Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... Agricultura (Fischer) and Sucocitrico Cutrale, S.A. (Cutrale). In Cutrale's request for an administrative... ``Calculations Performed for Fischer S.A. Comercio, Industria, and Agricultura for the Preliminary Results in the..., Industria and Agricultura.'' 2. Test of Comparison Market Sales Prices On a product-specific basis,...

  13. 77 FR 66580 - Certain Preserved Mushrooms From India: Preliminary Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-06

    ... International Trade Administration Certain Preserved Mushrooms From India: Preliminary Results of Antidumping... review of the antidumping duty order on certain preserved mushrooms (mushrooms) from India. The period of... merchandise subject to the order is certain preserved mushrooms. The product is currently classified under...

  14. 78 FR 29702 - Ball Bearings and Parts Thereof From Germany: Final Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-21

    ... International Trade Administration Ball Bearings and Parts Thereof From Germany: Final Results of Antidumping... order on ball bearings and parts thereof from Germany. The period of review (POR) is May 1, 2011... September 15, 2011, the Department revoked the order on ball bearings and parts thereof from Germany as...

  15. 77 FR 69792 - Certain Pasta From Turkey: Final Results of Countervailing Duty Administrative Review; 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... International Trade Administration Certain Pasta From Turkey: Final Results of Countervailing Duty... certain pasta from Turkey for the period January 1, 2010, through December 31, 2010. We received no... Bellini and produced the subject merchandise during the period of review. See Certain Pasta From...

  16. 78 FR 78335 - Lightweight Thermal Paper from Germany: Preliminary Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-26

    ... International Trade Administration Lightweight Thermal Paper from Germany: Preliminary Results of Antidumping... thermal paper (LWTP) from Germany. The period of review (POR) is November 1, 2011, through October 31... order is lightweight thermal paper. The merchandise subject to the order is currently classified...

  17. 77 FR 73615 - Lightweight Thermal Paper From Germany; Preliminary Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ...] Lightweight Thermal Paper From Germany; Preliminary Results of Antidumping Duty Administrative Review; 2010... duty order on lightweight thermal paper (LWTP) from Germany for the period November 1, 2010, through... covered by the order is lightweight thermal paper. The merchandise subject to the order is...

  18. 25 CFR 170.618 - Can a tribe keep savings resulting from project administration?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can a tribe keep savings resulting from project administration? 170.618 Section 170.618 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Service Delivery for Indian Reservation Roads Contracts...

  19. 78 FR 7395 - Stainless Steel Bar From India: Preliminary Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-01

    ... International Trade Administration Stainless Steel Bar From India: Preliminary Results of Antidumping Duty... the antidumping duty order on stainless steel bar (SSB) from India. The period of review (POR) is... Review: Stainless Steel Bar from India'' dated concurrently with this notice (``Preliminary...

  20. 75 FR 67689 - Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-03

    ... International Trade Administration Stainless Steel Bar From Brazil: Preliminary Results of Antidumping Duty... antidumping duty order on certain stainless steel bar from Brazil. The review covers one producer/ exporter of... Department published in the Federal Register an antidumping duty order on certain stainless steel bar...

  1. 77 FR 21724 - Certain Orange Juice From Brazil: Preliminary Results of Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ...). Reconstituted orange juice is produced through further manufacture of FCOJM, by adding water, oils and essences... Shrimp From India: Preliminary Results and Preliminary Partial Rescission of Antidumping Duty Administrative Review, 74 FR 9991, 9996 (Mar. 9, 2009), unchanged in Certain Frozen Warmwater Shrimp from...

  2. 77 FR 48966 - Saccharin From the People's Republic of China: Final Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ...: Preliminary Results of Antidumping Duty Administrative Review and Intent To Rescind in Part, 77 FR 21966... metalworking fluids. There are four primary chemical compositions of saccharin: (1) Sodium saccharin (American Chemical Society Chemical Abstract Service (``CAS'') Registry 128-44-9); (2) calcium saccharin...

  3. 76 FR 35405 - Solid Urea From the Russian Federation: Preliminary Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-17

    ... International Trade Administration Solid Urea From the Russian Federation: Preliminary Results of Antidumping... review of the antidumping duty order on solid urea from the Russian Federation (Russia). The review... solid urea from the Union of Soviet Socialist Republics (Soviet Union). See Antidumping Duty Order;...

  4. 69 FR 76450 - Honey from Argentina: Preliminary Results of Countervailing Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2004-12-21

    ... International Trade Administration C-357-813 Honey from Argentina: Preliminary Results of Countervailing Duty... countervailing duty order on honey from Argentina for the period January 1, 2003, through December 31, 2003. If... countervailing duty order on honey from Argentina. See Notice of Countervailing Duty Order: Honey From...

  5. 68 FR 69660 - Honey From Argentina: Preliminary Results of Countervailing Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2003-12-15

    ... International Trade Administration Honey From Argentina: Preliminary Results of Countervailing Duty... countervailing duty order on honey from Argentina for the period January 1, 2001 through December 31, 2002. If... Department published in the Federal Register the countervailing duty order on honey from Argentina....

  6. 75 FR 977 - Carbazole Violet Pigment 23 From India: Preliminary Results of Countervailing Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-07

    ... International Trade Administration Carbazole Violet Pigment 23 From India: Preliminary Results of Countervailing... pigment 23 (CVP-23) from India for the period January 1, 2007, through December 31, 2007. We preliminarily... Pigment 23 from India, 69 FR 77995 (December 29, 2004) (CVP-23 Order). On December 1, 2008, the...

  7. 78 FR 34648 - Citric Acid and Certain Citrate Salts: Preliminary Results of Countervailing Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-10

    ... International Trade Administration Citric Acid and Certain Citrate Salts: Preliminary Results of Countervailing... review of the countervailing duty (CVD) order on citric acid and citrate salts from the People's Republic... (202) 482-1503. Scope of the Order The merchandise subject to the order is citric acid and...

  8. The mid-IR and near-IR interferometry of AGNs: key results and their implications

    NASA Astrophysics Data System (ADS)

    Kishimoto, M.

    2015-09-01

    Infrared interferometry has been very productive in directly probing the structure of AGNs at sub-pc scales. With tens of objects already probed in the mid-IR and near-IR, I will summarize the key results and im- plications from this direct exploration. The Keck interferometry in the near-IR and VLTI in the mid-IR shaped the luminosity dependence of the torus size and structure, while the latter also revealed an equatorial structure at several Rsub (dust sublimation radius), and a polar-elongated region at a few tens of Rsub. Notably, this polar component seems to dominate the compact mid-IR flux. This component can persuasively be attributed to a polar outflow. However, interferometry, through emissivity estimations, also indicates that it is not a UV-optically-thin cloud but participating in the obscuration of the nucleus. I will discuss how to accommodate all these facts to build a consistent picture.

  9. Compulsory administration of oxytocin does not result in genuine moral enhancement.

    PubMed

    Rakić, Vojin

    2017-02-28

    The question will be raised whether oxytocin can serve as an effective moral enhancer. Different types of moral enhancement will be addressed, one of them being compulsory moral enhancement. It will be argued that oxytocin cannot serve as an effective moral enhancer if its use is being made compulsory. Hence, compulsory administration of oxytocin does not result in genuine moral enhancement. In order to demonstrate this, a stipulation of the main potentially beneficial outcomes of using oxytocin as a moral enhancer will be offered, as well as a discussion of objections to the notion that oxytocin can be an effective moral enhancer. It will be concluded that mandatory administration of oxytocin is ineffective because of a combination of two reasons: (1) mandatory administration of oxytocin renders moral reflection practically superfluous; (2) without moral reflection the beneficial outcomes of the use of oxytocin do not outweigh its drawbacks to the degree that we could speak of effective moral enhancement.

  10. Key results for the NRC`s Short Cracks in Piping and Piping Welds Research Program

    SciTech Connect

    Wilkowski, G.; Krishnaswamy, P.; Brust, F.

    1995-04-01

    The overall objective of the Short Cracks in Piping and Piping Welds Program is to verify and improve engineering analyses to predict the fracture behavior of circumferentially cracked pipe under quasi-static loading with particular attention to crack lengths typically used in LBB or flaw evaluation criteria. The USNCRC program at Battelle was initiated in March 1990 and is scheduled to be completed in December 1994. This paper discusses key results from the overall program with particular emphasis on the efforts since the last WRSIM meeting. The program consists of eight technical tasks as listed below: task 1 short through-wall-cracked (TWC) pipe evaluations; task 2 short surface-cracked (SC) pipe evaluations; task 3 bi-metallic weld crack evaluations; task 4 dynamic strain aging and crack instabilities; task 5 fracture evaluations of anisotropic pipe; task 6 crack-opening-area evaluations; task 7 NRCPIPE code improvements; task 8 additional efforts. Task 8 is a collection of new efforts initiated during the coarse of the program. A list of the full-scale pipe experiments in this program is given in Table 1. All of the experiments have been completed. The most recent accomplishments in each of the tasks listed above are discussed below. The details of all the results in the eight tasks are published in the semiannual reports as well as topical reports from the program.

  11. Analyzing Ethics in the Administration of Interscholastic Sports: Three Key Gender-Related Ethical Dilemmas Faced by Educational Leaders

    ERIC Educational Resources Information Center

    Whisenant, Warren A.; Pedersen, Paul M.; Clavio, Galen

    2010-01-01

    Athletic administrators and decision makers within interscholastic athletics are expected to embrace a code of ethics that serves as a set of rules to guide their professional behavior. Included within this code are areas of controversy that present gender-related ethical dilemmas for administrators. Three specific ethical dilemmas involve (1)…

  12. North Atlantic Aerosol Properties and Direct Radiative Effects: Key Results from TARFOX and ACE-2

    NASA Technical Reports Server (NTRS)

    Russell, P. B.; Livingston, J. M.; Schmid, B.; Bergstrom, R. A.; Hignett, P.; Hobbs, P. V.; Durkee, P. A.; Condon, Estelle (Technical Monitor)

    1998-01-01

    Aerosol effects on atmospheric radiative fluxes provide a forcing function that can change the climate in potentially significant ways. This aerosol radiative Forcing is a major source of uncertainty in understanding the observed climate change of the past century and in predicting, future climate. To help reduce this uncertainty, the International Global Atmospheric Chemistry Project (IGAC) has endorsed a series of multiplatform aerosol field campaigns. The Tropospheric Aerosol Radiative Forcing Observational Experiment (TARFOX) and the second Aerosol Characterization Experiment (ACE-2) were the first IGAC campaigns to address the impact of anthropogenic aerosols. Both TARFOX and ACE-2 gathered extensive data sets on aerosol properties and radiative effects. TARFOX focused on the urban-industrial haze plume flowing from the eastern United States over the western Atlantic Ocean, whereas ACE-2 studied aerosols carried over the eastern Atlantic from both European urban/industrial and African mineral sources. These aerosols often have a marked influence on the top-of-atmosphere radiances measured by satellites, as illustrated in Figure 1. Shown there are contours of aerosol optical depth derived from radiances measured by the AVHRR sensor on the NOAA-11 satellite. The contours readily show that aerosols originating in North America, Europe, and Africa impact the radiative properties of air over the North Atlantic. However, the accurate derivation of flux chances, or radiative forcing, from the satellite-measured radiances or 'etrieved optical depths remains a difficult challenge. In this paper we summarize key Initial results from TARFOX and, to a lesser extent ACE-2, with a focus on those results that allow an improved assessment of the flux changes caused by North Atlantic aerosols at middle and high latitudes.

  13. North Atlantic Aerosol Properties and Direct Radiative Effects: Key Results from TARFOX and ACE-2

    NASA Technical Reports Server (NTRS)

    Russell, P. B.; Livingston, J. M.; Schmid, B.; Bergstrom, Robert A.; Hignett, P.; Hobbs, P. V.; Durkee, P. A.

    2000-01-01

    Aerosol effects on atmospheric radiative fluxes provide a forcing function that can change the climate In potentially significant ways. This aerosol radiative forcing is a major source of uncertainty in understanding the observed climate change of the past century and in predicting future climate. To help reduce this uncertainty, the International Global Atmospheric Chemistry Project (IGAC) has endorsed a series of multiplatform aerosol field campaigns. The Tropospheric Aerosol Radiative Forcing Observational Experiment (TARFOX) and the second Aerosol Characterization Experiment (ACE-2) were the first IGAC campaigns to address the impact of anthropogenic aerosols, Both TARFOX and ACE-2 gathered extensive data sets on aerosol properties and radiative effects, TARFOX focused on the urban-industrial haze plume flowing from the eastern United States over the western Atlantic Ocean, whereas ACE-2 studied aerosols carried over the eastern Atlantic from both European urban/industrial and African mineral sources. These aerosols often have a marked influence on the top-of-atmosphere radiances measured by satellites. Shown there are contours of aerosol optical depth derived from radiances measured by the AVHRR sensor on the NOAA-11 satellite. The contours readily show that aerosols originating in North America, Europe, and Africa impact the radiative properties of air over the North Atlantic. However, the accurate derivation of flux changes, or radiative forcing, from the satellite measured radiances or retrieved optical depths remains a difficult challenge. In this paper we summarize key initial results from TARFOX and, to a lesser extent, ACE-2, with a focus on those results that allow an improved assessment of the flux changes caused by North Atlantic aerosols at middle latitudes.

  14. 75 FR 20812 - Silicon Metal from Brazil: Amended Final Results of Administrative Review Pursuant to Court Decision

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... International Trade Administration Silicon Metal from Brazil: Amended Final Results of Administrative Review... Metal from Brazil for the period of review beginning July 1, 1996, through June 30, 1997. See Silicon Metal from Brazil: Notice of Final Results of Antidumping Duty Administrative Review, 64 FR...

  15. Key questions resulting from the JUPITER trial assessing cardiovascular disease intervention with rosuvastatin.

    PubMed

    Rashid, Shirya

    2009-12-31

    THIS PAPER PRESENTS AN ANALYSIS OF THE RECENTLY PUBLISHED JUSTIFICATION FOR THE USE OF STATINS IN PREVENTION (JUPITER: an intervention trial evaluating rosuvastatin) trial, which tested the statin rosuvastatin in apparently healthy individuals with no prior cardiovascular (CVD) disease and with normal plasma low density lipoprotein (LDL) cholesterol concentrations but with raised plasma high sensitivity C-reactive protein (hsCRP) levels. The rate of the combined primary CVD endpoint was significantly reduced in the treatment arm after a median of under 2 years. The JUPITER trial is distinct from previous studies examining statin use in primary prevention groups because the target group for drug therapy was apparently healthy men and women at low or intermediate risk for developing CVD. On the basis of JUPITER's findings, there are key questions that should be assessed on the therapeutic intervention of CVD regarding: the primary prevention groups that should be targeted for statin therapy, the utility of targets in addition to plasma LDL cholesterol levels, and the need to consider the metabolic state of individuals targeted for therapy (including the presence of obesity and inflammation). The conclusion from the current analysis is that the JUPITER results warrant further LDL cholesterol lowering than is currently targeted in primary prevention groups that have a pre-existing condition or lifestyle that elevates CVD risk but still do not have a high global CVD risk (as assessed with current algorithms). This group is not captured in current widely used CVD risk calculations, however, with the identification of useful biomarkers, such as hsCRP, this group can be better identified and targeted for intervention.

  16. Is albumin administration in the acutely ill associated with increased mortality? Results of the SOAP study

    PubMed Central

    Vincent, Jean-Louis; Sakr, Yasser; Reinhart, Konrad; Sprung, Charles L; Gerlach, Herwig; Ranieri, V Marco

    2005-01-01

    Introduction Albumin administration in the critically ill has been the subject of some controversy. We investigated the use of albumin solutions in European intensive care units (ICUs) and its relationship to outcome. Methods In a cohort, multicenter, observational study, all patients admitted to one of the participating ICUs between 1 May and 15 May 2002 were followed up until death, hospital discharge, or for 60 days. Patients were classified according to whether or not they received albumin at any time during their ICU stay. Results Of 3,147 admitted patients, 354 (11.2%) received albumin and 2,793 (88.8%) did not. Patients who received albumin were more likely to have cancer or liver cirrhosis, to be surgical admissions, and to have sepsis. They had a longer length of ICU stay and a higher mortality rate, but were also more severely ill, as manifested by higher simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) scores than the other patients. A Cox proportional hazard model indicated that albumin administration was significantly associated with decreased 30-day survival. Moreover, in 339 pairs matched according to a propensity score, ICU and hospital mortality rates were higher in the patients who had received albumin than in those who had not (34.8 versus 20.9% and 41.3 versus 27.7%, respectively, both p < 0.001). Conclusion Albumin administration was associated with decreased survival in this population of acutely ill patients. Further prospective randomized controlled trials are needed to examine the effects of albumin administration in sub-groups of acutely ill patients. PMID:16356223

  17. Monitoring the Future National Results on Adolescent Drug Use: Overview of Key Findings, 2001.

    ERIC Educational Resources Information Center

    Johnston, Lloyd D.; O'Malley, Patrick M.; Bachman, Jerald G.

    This report presents an overview of the key findings from the Monitoring the Future 2001 nationwide survey of 8th, 10th, and 12th grade students. A particular emphasis is placed on recent trends in the use of licit and illicit drugs. Trends in the levels of perceived risk and personal disapproval associated with each drug--which this study has…

  18. Monitoring the Future: National Results on Adolescent Drug Use. Overview of Key Findings, 2002.

    ERIC Educational Resources Information Center

    Michigan Univ., Ann Arbor. Inst. for Social Research.

    This report presents an overview of the key findings from the Monitoring the Future 2002 nationwide survey of 8th, 10th, and 12th grade students. A particular emphasis is placed on recent trends in the use of licit and illicit drugs. Trends in the levels of perceived risk and personal disapproval associated with each drug--which this study has…

  19. Gemini Planet Imager Exoplanet Survey: Key Results Two Years Into The Survey

    NASA Astrophysics Data System (ADS)

    Marchis, Franck; Rameau, Julien; Nielsen, Eric L.; De Rosa, Robert J.; Esposito, Thomas; Draper, Zachary H.; Macintosh, Bruce; Graham, James R.; GPIES

    2016-10-01

    The Gemini Planet Imager Exoplanet Survey (GPIES) is targeting 600 young, nearby stars using the GPI instrument. We report here on recent results obtained with this instrument from our team.Rameau et al. (ApJL, 822 2, L2, 2016) presented astrometric monitoring of the young exoplanet HD 95086 b obtained with GPI between 2013 and 2016. Efficient Monte Carlo techniques place preliminary constraints on the orbital parameters of HD 95086 b. Under the assumption of a coplanar planet-disk system, the periastron of HD 95086 b is beyond 51 AU. Therefore, HD 95086 b cannot carve the entire gap inferred from the measured infrared excess in the SED of HD 95086. Additional photometric and spectroscopic measurements reported by de Rosa et al. (2016, apJ, in press) showed that the spectral energy distribution of HD 95086 b is best fit by low temperature (T~800-1300 K), low surface gravity spectra from models which simulate high photospheric dust content. Its temperature is typical to L/T transition objects, but the spectral type is poorly constrained. HD 95086 b is an important exoplanet to test our models of atmospheric properties of young extrasolar planets.Direct detections of debris disk are keys to infer the collisional past and understand the formation of planetary systems. Two debris disks were recently studied with GPI:- Draper et al. (submitted to ApJ, 2016) show the resolved circumstellar debris disk around HD 111520 at a projected range of ~30-100 AU using both total and polarized H-band intensity. Structures in the disks such as a large brightness asymmetry and symmetric polarization fraction are seen. Additional data would confirm if a large disruption event from a stellar fly-by or planetary perturbations altered the disk density- Esposito et al. (submitted to ApJ, 2016) combined Keck NIRC2 data taken at 1.2-2.3 microns and GPI 1.6 micron total intensity and polarized light detections that probes down to projected separations less than 10 AU to show that the HD

  20. Law, Policy and Nonproliferation Project Events and Workshops: Key Themes, Results and Related Materials 2008 - 2009

    DTIC Science & Technology

    2010-04-01

    treaty negotiating process to fill gaps in the international legal regime in the field of WMD SECTION TWO: KEY THEMES LAW, POLICY AND...science behind identifying the source of fissile materials used in a nuclear detonation. The process involves identifying the radiological signature of...fissile materials, which varies depending on whether uranium or plutonium serves as the basis of the nuclear fuel, and what enrichment processes were

  1. The Perceptions of Key Hospital Leaders as to the Competencies Required for Hospital Administration and Their Implications for Professional Education.

    ERIC Educational Resources Information Center

    Austin, Theodore Arnold

    This study sought to define competencies hospital executives need to perform their role effectively as perceived by hospital leaders, and to analyze the implications of these competency requirements for the professional education of hospital administrators. A semi-projective questionnaire was devised with the help of a panel of 10 administrators…

  2. 77 FR 69793 - Certain Pasta From Italy; Final Results of Countervailing Duty Administrative Review; 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... Review; 2010 AGENCY: Import Administration, International Trade Administration, Department of Commerce. SUMMARY: On August 1, 2012, the Department of Commerce (the ``Department'') published in the...

  3. Mont Terri Underground Rock Laboratory, Switzerland-Research Program And Key Results

    NASA Astrophysics Data System (ADS)

    Nussbaum, C. O.; Bossart, P. J.

    2012-12-01

    Argillaceous formations generally act as aquitards because of their low hydraulic conductivities. This property, together with the large retention capacity of clays for cationic contaminants and the potential for self-sealing, has brought clay formations into focus as potential host rocks for the geological disposal of radioactive waste. Excavated in the Opalinus Clay formation, the Mont Terri underground rock laboratory in the Jura Mountains of NW Switzerland is an important international test site for researching clay formations. Research is carried out in the underground facility, which is located adjacent to the security gallery of the Mont Terri motorway tunnel. Fifteen partners from European countries, USA, Canada and Japan participate in the project. The objectives of the research program are to analyze the hydrogeological, geochemical and rock mechanical properties of the Opalinus Clay, to determine the changes induced by the excavation of galleries and by heating of the rock formation, to test sealing and container emplacement techniques and to evaluate and improve suitable investigation techniques. For the safety of deep geological disposal, it is of key importance to understand the processes occurring in the undisturbed argillaceous environment, as well as the processes in a disturbed system, during the operation of the repository. The objectives are related to: 1. Understanding processes and mechanisms in undisturbed clays and 2. Experiments related to repository-induced perturbations. Experiments of the first group are dedicated to: i) Improvement of drilling and excavation technologies and sampling methods; ii) Estimation of hydrogeological, rock mechanical and geochemical parameters of the undisturbed Opalinus Clay. Upscaling of parameters from laboratory to in situ scale; iii) Geochemistry of porewater and natural gases; evolution of porewater over time scales; iv) Assessment of long-term hydraulic transients associated with erosion and thermal

  4. An animal model of schizophrenia based on chronic LSD administration: old idea, new results.

    PubMed

    Marona-Lewicka, Danuta; Nichols, Charles D; Nichols, David E

    2011-09-01

    Many people who take LSD experience a second temporal phase of LSD intoxication that is qualitatively different, and was described by Daniel Freedman as "clearly a paranoid state." We have previously shown that the discriminative stimulus effects of LSD in rats also occur in two temporal phases, with initial effects mediated by activation of 5-HT(2A) receptors (LSD30), and the later temporal phase mediated by dopamine D2-like receptors (LSD90). Surprisingly, we have now found that non-competitive NMDA antagonists produced full substitution in LSD90 rats, but only in older animals, whereas in LSD30, or in younger animals, these drugs did not mimic LSD. Chronic administration of low doses of LSD (>3 months, 0.16 mg/kg every other day) induces a behavioral state characterized by hyperactivity and hyperirritability, increased locomotor activity, anhedonia, and impairment in social interaction that persists at the same magnitude for at least three months after cessation of LSD treatment. These behaviors, which closely resemble those associated with psychosis in humans, are not induced by withdrawal from LSD; rather, they are the result of neuroadaptive changes occurring in the brain during the chronic administration of LSD. These persistent behaviors are transiently reversed by haloperidol and olanzapine, but are insensitive to MDL-100907. Gene expression analysis data show that chronic LSD treatment produced significant changes in multiple neurotransmitter system-related genes, including those for serotonin and dopamine. Thus, we propose that chronic treatment of rats with low doses of LSD can serve as a new animal model of psychosis that may mimic the development and progression of schizophrenia, as well as model the established disease better than current acute drug administration models utilizing amphetamine or NMDA antagonists such as PCP.

  5. 78 FR 22227 - Stainless Steel Bar From Brazil: Final Results of Antidumping Duty Administrative Review; 2011-2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-15

    ... International Trade Administration Stainless Steel Bar From Brazil: Final Results of Antidumping Duty... preliminary results of the administrative review of the antidumping duty order on stainless steel bar (SSB..., through January 31, 2012. \\1\\ See Stainless Steel Bar From Brazil: Preliminary Results of Antidumping...

  6. 78 FR 37794 - Polyvinyl Alcohol from Taiwan: Final Results of Antidumping Duty Administrative Review; 2010-2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... International Trade Administration Polyvinyl Alcohol from Taiwan: Final Results of Antidumping Duty... results of the administrative review of the antidumping duty order on polyvinyl alcohol (PVA) from Taiwan... February 29, 2012. \\1\\ See Polyvinyl Alcohol From Taiwan: Preliminary Results of Antidumping...

  7. Key Recent Scientific Results from the Opportunity Rover's Exploration of Cape Tribulation, Endeavour Crater, Mars

    NASA Astrophysics Data System (ADS)

    Arvidson, R. E.; Squyres, S. W.; Gellert, R.; Herkenhoff, K. E.; Mittlefehldt, D. W.; Crumpler, L. S.; McLennan, S. M.; Farrand, W. H.; Jolliff, B. L.; Morris, R. V.

    2015-12-01

    The Opportunity Rover is in its 11th year of exploration, currently exploring the Cape Tribulation rim segment of the ~22 km wide Noachian Endeavour Crater and its tilted and fractured outcrops. A key target for Opportunity's measurements has been the Spirit of Saint Louis crater (SoSL), which is ~25 m wide, oval in plan view, shallow, flat-floored, and has a slightly raised rim. SoSL crater is surrounded by an apron of bright, polygonally-shaped outcrops and is superimposed on a gentle swale in Cape Tribulation. Rocks in a thin reddish zone on the rim are enriched in hematite, Si, and Ge, and depleted in Fe, relative to surrounding rocks. Apron rocks include an outcrop also enriched in Si and Ge, and slightly depleted in Fe. In general rocks in the crater and apron have elevated S levels relative to Shoemaker formation breccias, tracking values observed in the Cook Haven (gentle swale superimposed on Murray Ridge and site of Opportunity's 5th winter site) and the Hueytown fracture (running perpendicular to Cape Tribulation) outcrops. SoSL crater lies just to the west of Marathon Valley, a key target for exploration by Opportunity because five separate CRISM observations indicate the presence of Fe/Mg smectites on the upper valley floor. Opportunity data show that low relief, relatively bright, wind-scoured outcrops dominate the valley floor where not covered by scree and soil shed from surrounding walls. Initial reconnaissance shows that the outcrops are breccias with compositions similar to the typical SoSL crater apron and floor rocks, although only the very upper portion of the valley has been explored as of August 2015. Pervasive but modest aqueous alteration of Endeavour's rim is implied by the combination of CRISM and Opportunity data, providing insight into early aqueous processes dominated in this location by relatively low water to rock ratios, and at least in part associated with enhanced fluid flow along fractures.

  8. KEY COMPARISON: Results of the key comparison CCM.FF-K4 for volume of liquids at 20 L and 100 mL

    NASA Astrophysics Data System (ADS)

    Arias, Roberto; Maldonado, Manuel; Wright, John; Jacques, Claude; Lachance, Christian; Lau, Peter; Többen, Helmut; Cignolo, Giorgio; Lorefice, Salvatore; Man, John; Aibe, Valter Y.

    2006-01-01

    A key comparison was performed in order to compare national measurement systems to determine volume of liquids, particularly at fixed volumes of 20 L and 100 mL. The participants were CENAM (Mexico), NIST (United States of America), NRC/MC (Canada), SP (Sweden), PTB (Germany), INRIM (former IMGC, Italy), NMIA (Australia) and INMETRO (Brazil). CENAM acted as pilot laboratory. The measurements were carried out from December 2003 to March 2005. The chosen values of volume (20 L and 100 mL) are both representatives of the Calibration and Measurement Capabilities (CMCs) declared by most of the participating national metrology institutes. The transfer standards (TSs) were three stainless steel pipettes for volume at 20 L and six commercially available glass pycnometers for volume at 100 mL. Prior to the beginning of the key comparison, the 20 L TSs were tested by CENAM, SP and NMIA The results of the test phase showed excellent values for both repeatability and reproducibility. During the CCM.FF-K4, the results of most of the laboratories showed good agreement with the reference values. The best estimation of the measurands, as reported by the participants showed a general agreement better than ±0.0025% for volume of liquids at 100 mL and 20 L. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  9. False-positive PCR results linked to administration of seasonal influenza vaccine.

    PubMed

    Curran, T; McCaughey, C; Ellis, J; Mitchell, S J; Feeney, S A; Watt, A P; Mitchell, F; Fairley, D; Crawford, L; McKenna, J; Coyle, P V

    2012-03-01

    False-positive PCR results usually occur as a consequence of specimen-to-specimen or amplicon-to-specimen contamination within the laboratory. Evidence of contamination at time of specimen collection linked to influenza vaccine administration in the same location as influenza sampling is described. Clinical, circumstantial and laboratory evidence was gathered for each of five cases of influenza-like illness (ILI) with unusual patterns of PCR reactivity for seasonal H1N1, H3N2, H1N1 (2009) and influenza B viruses. Two 2010 trivalent influenza vaccines and environmental swabs of a hospital influenza vaccination room were also tested for influenza RNA. Sequencing of influenza A matrix (M) gene amplicons from the five cases and vaccines was undertaken. Four 2009 general practitioner (GP) specimens were seasonal H1N1, H3N2 and influenza B PCR positive. One 2010 GP specimen was H1N1 (2009), H3N2 and influenza B positive. PCR of 2010 trivalent vaccines showed high loads of detectable influenza A and B RNA. Sequencing of the five specimens and vaccines showed greatest homology with the M gene sequence of Influenza A/Puerto Rico/8/1934 H1N1 virus (used in generation of influenza vaccine strains). Environmental swabs had detectable influenza A and B RNA. RNA detection studies demonstrated vaccine RNA still detectable for at least 66 days. Administration of influenza vaccines and clinical sampling in the same room resulted in the contamination with vaccine strains of surveillance swabs collected from patients with ILI. Vaccine contamination should therefore be considered, particularly where multiple influenza virus RNA PCR positive signals (e.g. H1N1, H3N2 and influenza B) are detected in the same specimen.

  10. Key Recent Scientific Results from the Opportunity Rover's Exploration of Endeavour Crater, Mars

    NASA Technical Reports Server (NTRS)

    Arvidson, R. E.; Squyres, S. W.; Gellert, R.; Herkenhoff, K.; Mittlefehldt, D.; Crumpler, L.; McLennan, S.; Farrand, W. H.; Joliff, B. L.; Morris, R. V.

    2015-01-01

    The Opportunity Rover is currently in its 11th year of operations, exploring the rim of the approximately 22 km wide Noachian-age Endeavour Crater. Opportunity spent its 5th winter season in Cook Haven, a gentle swale along Murray Ridge. Two small rocks serendipitously overturned by rover wheel motions show evidence for aqueous precipitation of sulfates, and interaction with a strong oxidant (e.g., O2) to form a thin, high valence state Mn oxide coating. After the winter, Opportunity headed south to Cape Tribulation and explored Shoemaker formation impact breccias, finding numerous Ca-sulfate veins cutting across outcrops. A key target for Opportunity's measurements has been the Spirit of Saint Louis crater (SoSL), which is approximately 25 m wide, oval in plan view, shallow, flat-floored, and has a slightly raised rim. SoSL crater is surrounded by an apron of bright, polygonally-shaped outcrops and is superimposed on a gentle swale in Cape Tribulation. Rocks in a thin reddish zone on the rim are enriched in hematite, Si, and Ge, and depleted in Fe, relative to surrounding rocks. Apron rocks include an outcrop also enriched in Si and Ge, and slightly depleted in Fe. In general rocks in the crater and apron have elevated S relative to Shoemaker formation breccias, tracking values observed in the Cook Haven and the Hueytown (fracture running perpendicular to Cape Tribulation) outcrops. SoSL crater lies just to the west of Marathon Valley, a key target for exploration by Opportunity because five separate CRISM observations indicate the presence of Fe/Mg smectites on the upper valley floor. Opportunity data show that low relief, relatively bright polygonal outcrops dominate the valley floor where not covered by scree and soil shed from surrounding walls. Initial reconnaissance shows that the outcrops are breccias with compositions similar to the typical SoSL crater apron and floor rocks, although only the very upper portion of the valley has been explored as of August

  11. 78 FR 34337 - Stainless Steel Bar From India: Final Results of Antidumping Duty Administrative Review; 2011-2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    ... International Trade Administration Stainless Steel Bar From India: Final Results of Antidumping Duty... results of the administrative review of the antidumping duty order on stainless steel bar from India... that Ambica has not sold subject merchandise at less than normal value. \\1\\ See Stainless Steel...

  12. Data-Driven School Administrator Behaviors and State Report Card Results

    ERIC Educational Resources Information Center

    Spencer, James A., Jr.

    2014-01-01

    The purpose of this study was to identify the principal behaviors that would define an instructional leader as being a data-driven school administrator and to assess current school administrators' levels of being data-driven. This research attempted to examine the relationship between the degree to which a principal was data-driven and the…

  13. Results of the Fall 1984 Survey of Napa Valley College Administrators, Classified Staff, and Faculty.

    ERIC Educational Resources Information Center

    Friedlander, Jack; Gocke, Sharon

    In November 1984, all administrators, classified staff, and faculty at Napa Valley College (NVC) were surveyed concerning a wide range of topics related to working at the institution. The survey, which was completed by 17 administrators (71%), 60 classified staff members (42%), 71 full-time faculty members (63%), and 79 part-time faculty members…

  14. 75 FR 32911 - Preliminary Results of Antidumping Duty Administrative Review: Circular Welded Carbon Steel Pipes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... Welded Carbon Steel Pipes and Tubes From Taiwan AGENCY: Import Administration, International Trade... administrative review of the antidumping duty order on circular welded carbon steel pipes and tubes from Taiwan... circular welded carbon steel pipes and tubes from Taiwan. See Certain Circular Welded Carbon Steel...

  15. 76 FR 33210 - Preliminary Results of Antidumping Duty Administrative Review: Circular Welded Carbon Steel Pipes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ... Welded Carbon Steel Pipes and Tubes From Taiwan AGENCY: Import Administration, International Trade... administrative review of the antidumping duty order on circular welded carbon steel pipes and tubes from Taiwan... circular welded carbon steel pipes and tubes from Taiwan. See Certain Circular Welded Carbon Steel...

  16. The ClinicalTrials.gov Results Database — Update and Key Issues

    PubMed Central

    Zarin, Deborah A.; Tse, Tony; Williams, Rebecca J.; Califf, Robert M.; Ide, Nicholas C.

    2011-01-01

    BACKGROUND The ClinicalTrials.gov trial registry was expanded in 2008 to include a database for reporting summary results. We summarize the structure and contents of the results database, provide an update of relevant policies, and show how the data can be used to gain insight into the state of clinical research. METHODS We analyzed ClinicalTrials.gov data that were publicly available between September 2009 and September 2010. RESULTS As of September 27, 2010, ClinicalTrials.gov received approximately 330 new and 2000 revised registrations each week, along with 30 new and 80 revised results submissions. We characterized the 79,413 registry and 2178 results of trial records available as of September 2010. From a sample cohort of results records, 78 of 150 (52%) had associated publications within 2 years after posting. Of results records available publicly, 20% reported more than two primary outcome measures and 5% reported more than five. Of a sample of 100 registry record outcome measures, 61% lacked specificity in describing the metric used in the planned analysis. In a sample of 700 results records, the mean number of different analysis populations per study group was 2.5 (median, 1; range, 1 to 25). Of these trials, 24% reported results for 90% or less of their participants. CONCLUSIONS ClinicalTrials.gov provides access to study results not otherwise available to the public. Although the database allows examination of various aspects of ongoing and completed clinical trials, its ultimate usefulness depends on the research community to submit accurate, informative data. PMID:21366476

  17. 75 FR 24880 - Administrative Review of Honey from the People's Republic of China: Final Results of Antidumping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... International Trade Administration Administrative Review of Honey from the People's Republic of China: Final... antidumping duty order on honey from the People's Republic of China (``PRC'').\\1\\ We gave interested parties... of Honey from the People's Republic of China: Preliminary Results of Antidumping Duty...

  18. 75 FR 66347 - Brass Sheet and Strip From Germany: Amended Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... International Trade Administration Brass Sheet and Strip From Germany: Amended Final Results of Antidumping Duty... brass sheet and strip (BSS) from Germany for the period of review (POR) March 1, 2008, through February... the administrative review of the antidumping duty order on brass sheet and strip (BSS) from...

  19. Maintenance of a health promotion program in elementary schools: results from the CATCH-ON study key informant interviews.

    PubMed

    Lytle, Leslie A; Ward, Jerri; Nader, Phillip R; Pedersen, Sheryl; Williston, B J

    2003-08-01

    To better understand the institutionalization process in Child and Adolescent Trial for Cardiovascular Health (CATCH) intervention and control schools, 199 key informant interviews were conducted with school food service staff, physical education teachers, classroom teachers, and administrators at the four CATCH-ON field centers. School personnel were asked to talk about the degree of CATCH program implementation, who at the school or school district was instrumental in promoting CATCH, and the conditions that facilitated or impeded the institutionalization of CATCH activities and philosophies. The CATCH Physical Education (PE) component appeared to have the highest level of institutionalization, and the CATCH classroom curriculum and family components appeared to have the lowest levels of institutionalization. The primary barriers expressed included the low priority for health promotion activities and time constraints of schools: lack of mechanisms for training of school staff; and lack of sufficient funds for materials, equipment, and lower fat vendor products.

  20. 78 FR 49256 - Certain Pasta From Italy: Preliminary Results of the Countervailing Duty Administrative Review; 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... Commerce. SUMMARY: The Department of Commerce (``Department'') is conducting an administrative review of..., 2011, through December 31, 2011. We preliminarily determine that Molino e Pastificio Tomasello...

  1. 77 FR 63291 - Certain Orange Juice From Brazil: Final Results of Antidumping Duty Administrative Review and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... respondents in this administrative review (i.e., Fischer S.A. Comercio, Industria, and Agricultura (Fischer..., Industria, and Agricultura 4.72 Louis Dreyfus Commodities Agroindustrial S.A 20.34 Montecitrus Trading...

  2. Key results of battery performance and life tests at Argonne National Laboratory

    NASA Astrophysics Data System (ADS)

    Deluca, W. H.; Gillie, K. R.; Kulaga, J. E.; Smaga, J. A.; Tummillo, A. F.; Webster, C. E.

    1991-12-01

    Advanced battery technology evaluations are performed under simulated electric vehicle operating conditions at Argonne National Laboratory's & Diagnostic Laboratory (ADL). The ADL provide a common basis for both performance characterization and life evaluation with unbiased application of tests and analyses. This paper summarizes the performance characterizations and life evaluations conducted in 1991 on twelve single cells and eight 3- to 360-cell modules that encompass six battery technologies (Na/S, Li/MS, Ni/MH, Zn/Br, Ni/Fe, and Pb-Acid). These evaluations were performed for the Department of Energy, Office of Transportation Technologies, Electric and Hybrid Propulsion Division. The results measure progress in battery R & D programs, compare battery technologies, and provide basic data for modeling and continuing R & D to battery users, developers, and program managers.

  3. Key results of battery performance and life tests at Argonne National Laboratory

    SciTech Connect

    DeLuca, W.H.; Gillie, K.R.; Kulaga, J.E.; Smaga, J.A.; Tummillo, A.F.; Webster, C.E.

    1991-12-31

    Advanced battery technology evaluations are performed under simulated electric vehicle operating conditions at Argonne National Laboratory`s & Diagnostic Laboratory (ADL). The ADL provide a common basis for both performance characterization and life evaluation with unbiased application of tests and analyses. This paper summarizes the performance characterizations and life evaluations conducted in 1991 on twelve single cells and eight 3- to 360-cell modules that encompass six battery technologies (Na/S, Li/MS, Ni/MH, Zn/Br, Ni/Fe, and Pb-Acid). These evaluations were performed for the Department of Energy, Office of Transportation Technologies, Electric and Hybrid Propulsion Division. The results measure progress in battery R & D programs, compare battery technologies, and provide basic data for modeling and continuing R & D to battery users, developers, and program managers.

  4. Key results of battery performance and life tests at Argonne National Laboratory

    SciTech Connect

    DeLuca, W.H.; Gillie, K.R.; Kulaga, J.E.; Smaga, J.A.; Tummillo, A.F.; Webster, C.E.

    1991-01-01

    Advanced battery technology evaluations are performed under simulated electric vehicle operating conditions at Argonne National Laboratory's Diagnostic Laboratory (ADL). The ADL provide a common basis for both performance characterization and life evaluation with unbiased application of tests and analyses. This paper summarizes the performance characterizations and life evaluations conducted in 1991 on twelve single cells and eight 3- to 360-cell modules that encompass six battery technologies (Na/S, Li/MS, Ni/MH, Zn/Br, Ni/Fe, and Pb-Acid). These evaluations were performed for the Department of Energy, Office of Transportation Technologies, Electric and Hybrid Propulsion Division. The results measure progress in battery R D programs, compare battery technologies, and provide basic data for modeling and continuing R D to battery users, developers, and program managers.

  5. Canine leishmaniasis: the key points for qPCR result interpretation

    PubMed Central

    2011-01-01

    Background Diagnosis and follow up of CanL is difficult since the range of clinical signs is varied and seroprevalence is high in endemic areas. The aims of this study were: i) demonstrate the advantages of Leishmania qPCR to diagnose and control CanL and highlight its prognostic value and ii) propose guidelines for tissue selection and infection monitoring. Findings This study included 710 dogs living in an endemic area of leishmaniasis. Forty percent (285/710) exhibited clinical signs consistent with CanL. Infection was detected in 36.3% (258/710) of the dogs of which 4.5% (32/710) were detected by qPCR, 16.2% (115/710) detected by ELISA and 15.6% (111/710) tested positive for both tests. Only 17.9% (127/710) of the dogs were classified sick (affected) with CanL. All symptomatic dogs with medium or high ELISA titers were qPCR-positive in blood samples. All dogs with inconclusive or low ELISA results with high or medium qPCR parasitemia values developed the disease. Seventy one percent of asymptomatic ELISA-positive dogs confirmed by qPCR (medium to high parasitemia) developed the disease. Bone marrow or lymph node aspirate should be selected to ensure the absence of the parasite in asymptomatic dogs: 100-1,000 parasites/ml in bone marrow are detectable in blood, whereas lower parasite loads are usually negative. Almost 10% of negative samples in blood were positive in conjunctival swabs. Conclusions Because qPCR allows parasite quantification, it is an effective tool to confirm a diagnosis of CanL in (i) cases of inconclusive ELISA results, (ii) when the dog has not yet seroconverted, or (iii) for treatment monitoring. PMID:21489253

  6. Determining barriers to creating an enabling environment in Cambodia: results from a baseline study with key populations and police

    PubMed Central

    Schneiders, Mira L; Weissman, Amy

    2016-01-01

    Introduction Cambodian law enforcement's limited acceptance of harm reduction has hindered HIV program effectiveness. With funding from the Australian Department of Foreign Affairs and Trade, FHI 360 supported the Ministry of Interior to implement the Police Community Partnership Initiative (PCPI) in Cambodia's capital Phnom Penh. To guide this, FHI 360 conducted a baseline study examining police and key populations’ attitudes and practices towards one another, including fear and occurrence of arrest. Methods Between December 2012 and January 2013, a cross-sectional survey of 199 police post officers, 199 people who use drugs (PWUD) including people who inject drugs (PWID), 199 men who have sex with men (MSM), 200 transgender women (TGW) and 200 female entertainment workers (FEW) was conducted in five Phnom Penh districts. Eligible participants were ≥18 years, members of a key population from selected hotspots or police officers, deputy chiefs or chiefs. Results Key populations’ median age was 25 years (IQR: 22–30); 40% had completed only primary school. Police were male (99.5%), with median age 43 years (IQR: 30 to 47), and 45 and 25% high school and university completion rates, respectively. Key populations feared arrest for carrying needles and syringes (67%), condoms (23%) and 19% felt afraid to access health services. Close to 75% of police reported body searching and 58% arresting key populations in the past six months for using drugs (64%), selling or distributing drugs (36%) or being violent (13%). Self-reported arrests (23% PWUD, 6% MSM, 6% TGW, 12% FEW; p<0.05), being verbally threatened (45% PWUD, 21% MSM, 25% TGW, 27% FEW; p<0.001) and body searched (44% PWUD, 28% MSM, 23% TGW, 8% FEW; p<0.001) was significantly higher among PWUD than other key populations. The majority (94%) of police believed arrest was an appropriate solution to reduce HIV and drug use and reported selling sex (88%) and carrying needles and syringes (55%) as valid reasons for

  7. Sequential drug verification errors resulting in wrong drug administration during caesarean section.

    PubMed

    Calderbank, S; Uncles, D R; Burns, N; Kariyawasam, H K C D; Allan, G D L

    2011-01-01

    An intravenous bolus of phentolamine was inadvertently given to a parturient during an emergency caesarean section following delivery of her infant when the intention had been to give an intravenous bolus of 5 IU Syntocinon. Root cause analysis identified a series of errors originating in the hospital pharmacy when one drug package was mistakenly issued in place of another. Subsequent checks failed to detect the original mistake. The final and most important check immediately before intravenous administration was also at fault. This case highlights a systems failure that permitted issue, transportation and administration of the wrong drug to a parturient. Robust measures to ensure avoidance of drug administration errors should be evaluated and introduced where possible.

  8. College and University Dining Services Administrators' Intention to Adopt Sustainable Practices: Results from US Institutions

    ERIC Educational Resources Information Center

    Chen, Chao-Jung; Gregoire, Mary B.; Arendt, Susan; Shelley, Mack C.

    2011-01-01

    Purpose: The purpose of this paper is to examine college and university dining services administrators' (CUDSAs) intention to adopt sustainable practices. Design/methodology/approach: The theory of planned behavior (TPB) including constructs of subjective norm (SN), attitude, perceived behavior control, and personal norm (PN), formed the…

  9. 75 FR 12199 - Stainless Steel Bar from India: Preliminary Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-15

    ... (February 9, 2009) (``SSSS from Mexico'') and accompanying Issues and Decision Memorandum at Comment 5. 1... Administrative Review, 73 FR 45708, 45710 (August 6, 2008), unchanged in SSSS from Mexico and accompanying Issues... SSSS from Mexico and accompanying Issues and Decision Memorandum at Comment 5; see also SSPC...

  10. 69 FR 77195 - Honey From Argentina: Preliminary Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2004-12-27

    ...] [FR Doc No: 04-28220] DEPARTMENT OF COMMERCE International Trade Administration [A-357-812] Honey From... antidumping order of honey from Argentina. The review covers seven firms. The period of review (POR) is December 1, 2002 through November 30, 2003. We preliminarily determine that sales of honey from...

  11. Diagnosing Key Drivers of Job Impact and Business Results Attributable to Training at the Defense Acquisition University

    DTIC Science & Technology

    2011-10-01

    Management Science , 33(6), 687–705. Wold , H. (1975). Path models with latent variables: The NIPALS approach. In H. M. Blalock, A. Aganbegian, F. M...developed by Wold (1975), and it focuses on maximizing the Diagnosing Key Drivers of Job impact and Business Results October 2011 Attributable to Training...perfectly would have an R2 value of 100 percent, although this situation is virtually impossible to achieve in social science research. To put this

  12. Patient advocacy: one agency's positive results with the administrative law judge process.

    PubMed

    Kimaid, Y; Votava, K M; Myers, E

    1994-01-01

    The Visiting Nurse Service of Rochester and Monroe County, Inc., is a progressive, certified home health agency that is committed to providing a broad range of specialized high-quality care services. To assist in meeting this goal, the Visiting Nurse Service has developed a Network of Support to maximize the patients' access to Medicare home care benefits. This commitment as a patient advocate follows through to the process of dealing with Medicare denials up to the level of the Administrative Law Judge.

  13. Regulatory perspectives on pharmacogenomics: a review of the literature on key issues faced by the United States Food and Drug Administration.

    PubMed

    Phillips, Kathryn A; Van Bebber, Stephanie L

    2006-06-01

    Pharmacogenomics (PGx), the use of genetic information to individualize drug therapy, is an immediate and important application of the Human Genome Project. The advent of PGx presents challenges to the U.S. Food and Drug Administration (FDA) in pursuing its mandate of protecting public health and safety. The authors conducted a review of academic, industry, and government literature using a technology diffusion framework to identify issues faced by the FDA relevant to the application of PGx. Two hundred and ten articles were reviewed. Key issues were categorized as rationale and structure for PGx regulation, regulation of PGx-based testing technologies, regulation of applications in clinical settings, regulation of data, and regulation of product life cycles. This review identifies issues faced by the FDA with respect to PGx, which the FDA is addressing through several initiatives. It also illustrates the complex issues involved in developing, implementing, and adopting new technologies.

  14. Maternal Intravenous Administration of Azithromycin Results in Significant Fetal Uptake in a Sheep Model of Second Trimester Pregnancy

    PubMed Central

    Miura, Yuichiro; Payne, Matthew S.; Jobe, Alan H.; Kallapur, Suhas G.; Saito, Masatoshi; Stock, Sarah J.; Spiller, O. Brad; Ireland, Demelza J.; Yaegashi, Nobuo; Clarke, Michael; Hahne, Dorothee; Rodger, Jennifer; Keelan, Jeffrey A.; Newnham, John P.

    2014-01-01

    Treatment of intrauterine infection is likely key to preventing a significant proportion of preterm deliveries before 32 weeks of gestation. Azithromycin (AZ) may be an effective antimicrobial in pregnancy; however, few gestation age-approriate data are available to inform the design of AZ-based treatment regimens in early pregnancy. We aimed to determine whether a single intra-amniotic AZ dose or repeated maternal intravenous (i.v.) AZ doses would safely yield therapeutic levels of AZ in an 80-day-gestation (term is 150 days) ovine fetus. Fifty sheep carrying single pregnancies at 80 days gestation were randomized to receive either: (i) a single intra-amniotic AZ administration or (ii) maternal intravenous AZ administration every 12 h. Amniotic fluid, maternal plasma, and fetal AZ concentrations were determined over a 5-day treatment regimen. Markers of liver injury and amniotic fluid inflammation were measured to assess fetal injury in response to drug exposure. A single intra-amniotic administration yielded significant AZ accumulation in the amniotic fluid and fetal lung. In contrast, repeated maternal intravenous administrations achieved high levels of AZ accumulation in the fetal lung and liver and a statistically significant increase in the fetal plasma drug concentration at 120 h. There was no evidence of fetal injury in response to drug exposure. These data suggest that (i) repeated maternal i.v. AZ dosing yields substantial fetal tissue uptake, although fetal plasma drug levels remain low; (ii) transfer of AZ from the amniotic fluid is less than transplacental transfer; and (iii) exposure to high concentrations of AZ did not elicit overt changes in fetal white blood cell counts, amniotic fluid monocyte chemoattractant protein 1 concentrations, or hepatotoxicity, all consistent with an absence of fetal injury. PMID:25155606

  15. Cold-water event of January 2010 results in catastrophic benthic mortality on patch reefs in the Florida Keys

    NASA Astrophysics Data System (ADS)

    Colella, M. A.; Ruzicka, R. R.; Kidney, J. A.; Morrison, J. M.; Brinkhuis, V. B.

    2012-06-01

    The Florida Keys are periodically exposed to extreme cold-water events that can have pronounced effects on coral reef community structure. In January 2010, the Florida Keys experienced one of the coldest 12-day periods on record, during which water temperatures decreased below the lethal limit for many tropical reef taxa for several consecutive days. This study provides a quantitative assessment of the scleractinian mortality and acute changes to benthic cover at four patch reefs in the middle and upper Keys that coincided with this cold-water event. Significant decreases in benthic cover of scleractinian corals, gorgonians, sponges, and macroalgae were observed between summer 2009 and February 2010. Gorgonian cover declined from 25.6 ± 4.6% (mean ± SE) to 13.3 ± 2.7%, scleractinian cover from 17.6 ± 1.4% to 10.7 ± 0.9%, macroalgal cover from 8.2 ± 5.2% to 0.7 ± 0.3%, and sponge cover from 3.8 ± 1.4% to 2.3 ± 1.2%. Scleractinian mortality varied across sites depending upon the duration of lethal temperatures and the community composition. Montastraea annularis complex cover was reduced from 4.4 ± 2.4% to 0.6 ± 0.2%, and 93% of all colonies surveyed suffered complete or partial mortality. Complete or partial mortality was also observed in >50% of all Porites astreoides and Montastraea cavernosa colonies and resulted in a significant reduction in cover. When compared with historical accounts of cold-water-induced mortality, our results suggest that the 2010 winter mortality was one of the most severe on record. The level of coral mortality on patch reefs is of particular concern because corals in these habitats had previously demonstrated resistance against stressors (e.g., disease and warm-water bleaching) that had negatively affected corals in other habitats in the Florida Keys during recent decades.

  16. 76 FR 68399 - Certain Pasta From Turkey: Notice of Final Results of the 14th Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... International Trade Administration Certain Pasta From Turkey: Notice of Final Results of the 14th Antidumping... Turkey (pasta).\\1\\ The review covers one exporter: Marsan Gida Sanayi ve Ticaret A.S. (Marsan). The period of review (POR) is July 1, 2009, through June 30, 2010. \\1\\ See Certain Pasta From Turkey:...

  17. Results from the Veterans Health Administration ICD-10-CM/PCS Coding Pilot Study.

    PubMed

    Weems, Shelley; Heller, Pamela; Fenton, Susan H

    2015-01-01

    The Veterans Health Administration (VHA) of the US Department of Veterans Affairs has been preparing for the October 1, 2015, conversion to the International Classification of Diseases, Tenth Revision, Clinical Modification and Procedural Coding System (ICD-10-CM/PCS) for more than four years. The VHA's Office of Informatics and Analytics ICD-10 Program Management Office established an ICD-10 Learning Lab to explore expected operational challenges. This study was conducted to determine the effects of the classification system conversion on coding productivity. ICD codes are integral to VHA business processes and are used for purposes such as clinical studies, performance measurement, workload capture, cost determination, Veterans Equitable Resource Allocation (VERA) determination, morbidity and mortality classification, indexing of hospital records by disease and operations, data storage and retrieval, research purposes, and reimbursement. The data collection for this study occurred in multiple VHA sites across several months using standardized methods. It is commonly accepted that coding productivity will decrease with the implementation of ICD-10-CM/PCS. The findings of this study suggest that the decrease will be more significant for inpatient coding productivity (64.5 percent productivity decrease) than for ambulatory care coding productivity (6.7 percent productivity decrease). This study reveals the following important points regarding ICD-10-CM/PCS coding productivity: 1. Ambulatory care ICD-10-CM coding productivity is not expected to decrease as significantly as inpatient ICD-10-CM/PCS coding productivity. 2. Coder training and type of record (inpatient versus outpatient) affect coding productivity. 3. Inpatient coding productivity is decreased when a procedure requiring ICD-10-PCS coding is present. It is highly recommended that organizations perform their own analyses to determine the effects of ICD-10-CM/PCS implementation on coding productivity.

  18. The Hubble Space Telescope quasar absorption line key project. III - First observational results on Milky Way gas

    NASA Technical Reports Server (NTRS)

    Savage, Blair D.; Lu, Limin; Bahcall, John N.; Bergeron, Jacqueline; Boksenberg, Alec; Hartig, George F.; Jannuzi, Buell T.; Kirhakos, Sofia; Lockman, Felix J.; Sargent, W. L. W.

    1993-01-01

    Absorption lines found near zero redshift due to Milky Way disk and halo gas in the spectra of 15 quasars observed with the Faint Object Spectrograph (FOS) of the HST at a resolution of about 230 km/s are reported. Results show that Milky Way absorption lines comprise about 44 percent of all absorption lines seen in the first group of Key Project FOS spectra. Milky Way lines were observed for 3C 273 and H1821 + 643. Limits to the Mg-to-H abundance ratio obtained for very high velocity Mg II absorption detections imply gas-phase Mg abundances for the very high velocity gas ranging from more than 0.059 to more than 0.32 times the solar abundance. In all cases where high-velocity H I emission is seen, corresponding high-velocity metal-line absorption is observed.

  19. Acute and chronic administration of ibogaine to the rat results in astrogliosis that is not confined to the cerebellar vermis.

    PubMed

    O'Callaghan, J P; Rogers, T S; Rodman, L E; Page, J G

    1996-10-31

    Acute administration of high doses of ibogaine (IBG) to the male rat results in degeneration of Purkinje cells and reactive gliosis in the cerebellar vermis. We examined whether acute and chronic administration of IBG to male and female rats results in gliosis as determined by quantification of the astroglial intermediate filament protein, glial fibrillary acidic protein (GFAP). After acute administration of IBG, rats of both sexes showed dose-related increases in GFAP that were not confined to the cerebellar vermis. After chronic administration of IBG, female, but not male rats, showed large (as much as 200% of control), dose-related increases in GFAP in hippocampus, olfactory bulbs, brain stem and striatum, but not cerebellum. In hippocampus, the cytoskeletal proteins, neurofilament 68 (NF-68) and beta-tubulin were increased in females treated chronically with IBG, findings consistent with a damage-induced sprouting response. Together, the data indicate that IBG damages areas of the brain outside the cerebellum and that the sites damaged are dependent on sex and dosage regimen.

  20. HINDBRAIN AND CRANIAL NERVE DYSMORPHOGENESIS RESULT FROM ACUTE MATERNAL ETHANOL ADMINISTRATION

    EPA Science Inventory

    Acute exposure of mouse embryos to ethanol during stages of hindbrain segmentation results in excessive cell death in specific cell populations. This study details the ethanol-induced cell loss and defines the subsequent effects of this early insult on rhombomere and cranial ner...

  1. 75 FR 54090 - Stainless Steel Bar From India: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ...-average dumping margins for the reviewed firms, Ambica Steels Limited (``Ambica'') and Venus Wire... reasons explained in the Preliminary Results, we have determined that Venus Wire Industries Pvt. Ltd. and... File, ``Relationship of Venus Wire Industries Pvt. Ltd. and Sieves Manufacturers (India) Pvt....

  2. 78 FR 20891 - Glycine From the People's Republic of China: Final Results of Antidumping Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... Chemistry Co. Ltd. (Baoding Mantong), and are rescinding the review with respect to companies for which this... Baoding Mantong Fine 453.79% Chemistry Co., Ltd.) Assessment Rates Consistent with these final results... Pharmachem Inc. 2. Advance Exports 3. AICO Laboratories India Ltd. 4. Avid Organics Pvt. Ltd. 5....

  3. 25 CFR 558.2 - Review of notice of results for a key employee or primary management official.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... management official. 558.2 Section 558.2 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GAMING LICENSES AND BACKGROUND INVESTIGATIONS FOR KEY EMPLOYEES AND PRIMARY MANAGEMENT OFFICIALS GAMING LICENSES FOR KEY EMPLOYEES AND PRIMARY MANAGEMENT OFFICIALS § 558.2 Review of notice of...

  4. 25 CFR 558.2 - Review of notice of results for a key employee or primary management official.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... management official. 558.2 Section 558.2 Indians NATIONAL INDIAN GAMING COMMISSION, DEPARTMENT OF THE INTERIOR GAMING LICENSES AND BACKGROUND INVESTIGATIONS FOR KEY EMPLOYEES AND PRIMARY MANAGEMENT OFFICIALS GAMING LICENSES FOR KEY EMPLOYEES AND PRIMARY MANAGEMENT OFFICIALS § 558.2 Review of notice of...

  5. Colorectal Cancer Screening Programme in Spain: Results of Key Performance Indicators After Five Rounds (2000–2012)

    PubMed Central

    Binefa, Gemma; Garcia, Montse; Milà, Núria; Fernández, Esteve; Rodríguez-Moranta, Francisco; Gonzalo, Núria; Benito, Llúcia; Clopés, Ana; Guardiola, Jordi; Moreno, Víctor

    2016-01-01

    Effective quality assurance is essential in any screening programme. This article provides a unique insight into key quality indicators of five rounds of the first population-based colorectal cancer screening programme implemented in Spain (2000–2012), providing the results according to the type of screening (prevalent or first screen and incident or subsequent screen) and test (guaiac or immunochemical). The total crude participation rate increased from 17.2% (11,011) in the first round to 35.9% (22,988) in the last one. Rescreening rate was very high (88.6% in the fifth round). Positivity rate was superior with the faecal immunochemical test (6.2%) than with the guaiac-based test (0.7%) (p < 0.0001) and detection rates were also better with the immunochemical test. The most significant rise in detection rate was observed for high risk adenoma in men (45.5 per 1,000 screened). Most cancers were diagnosed at an early stage (61.4%) and there was a statistically significant difference between those detected in first or subsequent screening (52.6% and 70.0% respectively; p = 0.024). The availability of these results substantially improves data comparisons and the exchange of experience between screening programmes. PMID:26787510

  6. Liver Necrosis and Lipid Peroxidation in the Rat as the Result of Paraquat and Diquat Administration

    PubMed Central

    Burk, Raymond F.; Lawrence, Richard A.; Lane, James M.

    1980-01-01

    Paraquat and diquat facilitate formation of superoxide anion in biological systems, and lipid peroxidation has been postulated to be their mechanism of toxicity. Paraquat has been shown to be more toxic to selenium-deficient mice than to controls, presumably as the result of decreased activity of the selenoenzyme glutathione peroxidase. The present study was designed to measure lipid peroxidation and to assess toxicity in control and selenium-deficient rats given paraquat and diquat. Lipid peroxidation was measured by determining ethane production rates of intact animals; toxicity was assessed by survival and by histological and serum enzyme evidence of liver and kidney necrosis. Paraquat and diquat were both much more toxic to selenium-deficient rats than to control rats. Diquat (19.5 μmol/kg) caused rapid and massive liver and kidney necrosis and very high ethane production rates in selenium-deficient rats. The effect of paraquat (78 μmol/kg) was similar to that of diquat but was not as severe. Acutely lethal doses of paraquat (390 μmol/kg) and diquat (230 μmol/kg) in control rats caused very little ethane production and no evidence of liver necrosis. These findings suggest that paraquat and diquat exert their acute toxicity largely through lipid peroxidation in selenium-deficient rats. Selenium deficiency had no effect on superoxide dismutase activity in erythrocytes or in 105,000 g supernate of liver or kidney. Glutathione peroxidase, which represents the only well-characterized biochemical function of selenium in animals, was dissociated from the protective effect of selenium against diquat-induced lipid peroxidation and toxicity by a time-course study in which selenium-deficient rats were injected with 50 μg of selenium and later given diquat (19.5 μmol/kg). Within 10 h, the selenium injection provided significant protection against diquat-induced lipid peroxidation and mortality even though this treatment resulted in no rise in glutathione peroxidase

  7. Repeated cocaine administration results in supersensitivity of striatal D-2 dopamine autoreceptors to pergolide

    SciTech Connect

    Dwoskin, L.P.; Peris, J.; Yasuda, R.P.; Philpott, K.; Zahniser, N.R.

    1988-01-01

    Groups of rats administered cocaine-HCl (10 mg/kg, i.p.) or saline either acutely or once daily for 8 or 14 days were killed 24 hrs after the last dose. In striatal slices prelabelled with (/sup 3/H)DA, modulation of (/sup 3/H)-overflow by pergolide was used to measure D-2 autoreceptor activity. Compared to the contemporaneous control group pergolide produced a greater inhibition only in striatal slices from rats treated repeatedly with cocaine. In radioligand binding studies using striatal membranes from control rats, pergolide had a 500-fold greater affinity for the D-2, as opposed to the D-1, dopamine (DA) receptor subtype. These results indicate that repeated treatment with cocaine produces supersensitive striatal D-2 release-modulating autoreceptors consistent with a compensatory change to diminish the effect of elevated synaptic concentrations of DA produced by cocaine. In contrast, supersensitivity of D-2 receptors was not detected in (/sup 3/H)spiperone binding assays. 31 references, 2 figures, 1 table.

  8. Expression profile of key immune-related genes in Penaeus monodon juveniles after oral administration of recombinant envelope protein VP28 of white spot syndrome virus.

    PubMed

    Thomas, Ancy; Sudheer, Naduvilamuriparampu Saidumuhammed; Kiron, Viswanath; Bright Singh, Issac S; Narayanan, Rangarajan Badri

    2016-07-01

    White spot syndrome virus (WSSV) is the most catastrophic pathogen the shrimp industry has ever encountered. VP28, the abundant envelope protein of WSSV was expressed in bacteria, the purified protein administered orally to Penaeus monodon juveniles and its immune modulatory effects examined. The results indicated significant up-regulation of caspase, penaeidin, crustin, astakine, syntenin, PmRACK, Rab7, STAT and C-type lectin in animals orally administered with this antigen. This revealed the immune modulations in shrimps followed by oral administration of rVP28P which resulted in the reduced transcription of viral gene vp28 and delay in mortality after WSSV challenge. The study suggests the potential of rVP28P to elicit a non-specific immune stimulation in shrimps.

  9. New seismic reflection results in the central Eromanga Basin, Queensland, Australia: The key to understanding its tectonic evolution

    NASA Astrophysics Data System (ADS)

    Wake-Dyster, K. D.; Moss, F. J.; Sexton, M. J.

    1983-12-01

    Regional seismic traverses were recorded from 1980 to 1982 by the Bureau of Mineral Resources, Geology and Geophysics as part of a major multidisciplinary program aimed at studying the geological evolution of the central Eromanga Basin area and its petroleum potential. Six-fold CDP reflection data were obtained to 20 s reflection time on 1400 km of traverses, up to 400 km long, crossing the main structural features of the area. Additional seismic reflection information to complement the study was obtained from 2300 km of older, mainly single coverage analogue data, which was transcribed to digital format and reprocessed. The central Eromanga Basin area has a complex history and contains four Phanerozoic potentially hydrocarbon-bearing basins each separated by unconformities, i.e. the Devonian Adavale Basin, the Late Carboniferous to Triassic Cooper and Galilee basins, and the Jurassic-Cretaceous Eromanga Basin. The seismic results are being interpreted, with the aid of synthetic seismograms from key wells, to provide information on the extent, nature and relationship of these basins. The quality of the reflection data from the Devonian sequence is generally very good and these data are proving to be most useful in the study. Thick Devonian sediments were deposited over a wide area well beyond the present confines of the Adavale Basin and its associated troughs. Intensive folding and faulting accompanied by major basement uplift, including the Canaway Ridge in the centre of the area, took place during the mid-Carboniferous Kanimblan Orogeny. This was followed by a period of erosion which truncated the Devonian sequence and resulted in separation of the Adavale Basin from the other Devonian Troughs in the area. The preliminary seismic results give some indication also of the extent and nature of the Cooper and Galilee basins sediments. These are generally thin in the central area and thicken to the west and east respectively where coal measures produce good

  10. Constructing a Cross-Domain Resource Inventory: Key Components and Results of the EarthCube CINERGI Project.

    NASA Astrophysics Data System (ADS)

    Zaslavsky, I.; Richard, S. M.; Malik, T.; Hsu, L.; Gupta, A.; Grethe, J. S.; Valentine, D. W., Jr.; Lehnert, K. A.; Bermudez, L. E.; Ozyurt, I. B.; Whitenack, T.; Schachne, A.; Giliarini, A.

    2015-12-01

    While many geoscience-related repositories and data discovery portals exist, finding information about available resources remains a pervasive problem, especially when searching across multiple domains and catalogs. Inconsistent and incomplete metadata descriptions, disparate access protocols and semantic differences across domains, and troves of unstructured or poorly structured information which is hard to discover and use are major hindrances toward discovery, while metadata compilation and curation remain manual and time-consuming. We report on methodology, main results and lessons learned from an ongoing effort to develop a geoscience-wide catalog of information resources, with consistent metadata descriptions, traceable provenance, and automated metadata enhancement. Developing such a catalog is the central goal of CINERGI (Community Inventory of EarthCube Resources for Geoscience Interoperability), an EarthCube building block project (earthcube.org/group/cinergi). The key novel technical contributions of the projects include: a) development of a metadata enhancement pipeline and a set of document enhancers to automatically improve various aspects of metadata descriptions, including keyword assignment and definition of spatial extents; b) Community Resource Viewers: online applications for crowdsourcing community resource registry development, curation and search, and channeling metadata to the unified CINERGI inventory, c) metadata provenance, validation and annotation services, d) user interfaces for advanced resource discovery; and e) geoscience-wide ontology and machine learning to support automated semantic tagging and faceted search across domains. We demonstrate these CINERGI components in three types of user scenarios: (1) improving existing metadata descriptions maintained by government and academic data facilities, (2) supporting work of several EarthCube Research Coordination Network projects in assembling information resources for their domains

  11. Board/Administrator Relations. A Manual for Workshop Leaders. Keys to School Boardsmanship. A Program of Continuing Education for School Board Members.

    ERIC Educational Resources Information Center

    Jongeward, Ray E.

    The materials in this manual are designed to help workshop leaders prepare for and present a workshop for school board members on relations between school boards and administrators. Four elements basic to the establishment of effective relationships are reviewed: clarification of the roles and goals of the board and the administrators; effective…

  12. Antenna Heights for the Optimum Utilization of the Oceanic Evaporation Duct. Part 1. Results from the Pacific Measurements. Part 2. Results from the Key West Measurements. Volume 1

    DTIC Science & Technology

    1988-01-01

    evaporation ducting measurements wore conducted over a period of 1 year in the Southern California off- shore area and for 2 weeks between Key Wast and the...WORD In the early 1970s, a series of extensive evaporation ducting measurements was conducted in different ocean areas . The purpose of the measurements...period of one year in the Southern California off-shore area . The purpose of the measurements was to determine antenna heights for optimum

  13. Acute adverse event signalling scheme using the Saskatchewan Administrative health care utilization datafiles: results for two benzodiazepines.

    PubMed

    Rawson, N S; Rawson, M J

    1999-01-01

    Linked administrative health care utilization databases offer potential benefits for postmarketing surveillance. The value of the Saskatchewan datafiles in an acute adverse event signalling scheme has been evaluated using two benzodiazepines. The first 20,000 patients dispensed lorazepam and the first 8525 patients dispensed alprazolam were followed through the datafiles over the year after their initial prescription of the relevant drug, and all medical services occurring during treatment were recorded. The most frequent adverse drug reactions to benzodiazepines are drowsiness, depression, impaired intellectual function and memory, lethargy, impaired coordination, dizziness, nausea and/or vomiting, skin rash, and respiratory disturbance. Data from our study showed that sleep disorders, depressive disorders, dizziness and/or vertigo, respiratory symptoms, esophagus and stomach disorders, and inflammatory skin conditions occurred significantly more often in the first 30 days after the initial prescription than in the succeeding six months in both drug groups, indicating that they are important adverse events. There are several limitations to the methodology; however, the results of the analysis indicate that the use of administrative health care utilization datafiles in a systematic assessment to signal potential acute adverse drug reactions is a feasible proposition, but further studies are required to assess whether events are real adverse reactions.

  14. Administration of thimerosal-containing vaccines to infant rhesus macaques does not result in autism-like behavior or neuropathology.

    PubMed

    Gadad, Bharathi S; Li, Wenhao; Yazdani, Umar; Grady, Stephen; Johnson, Trevor; Hammond, Jacob; Gunn, Howard; Curtis, Britni; English, Chris; Yutuc, Vernon; Ferrier, Clayton; Sackett, Gene P; Marti, C Nathan; Young, Keith; Hewitson, Laura; German, Dwight C

    2015-10-06

    Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder. Some anecdotal reports suggest that ASD is related to exposure to ethyl mercury, in the form of the vaccine preservative, thimerosal, and/or receiving the measles, mumps, rubella (MMR) vaccine. Using infant rhesus macaques receiving thimerosal-containing vaccines (TCVs) following the recommended pediatric vaccine schedules from the 1990s and 2008, we examined behavior, and neuropathology in three brain regions found to exhibit neuropathology in postmortem ASD brains. No neuronal cellular or protein changes in the cerebellum, hippocampus, or amygdala were observed in animals following the 1990s or 2008 vaccine schedules. Analysis of social behavior in juvenile animals indicated that there were no significant differences in negative behaviors between animals in the control and experimental groups. These data indicate that administration of TCVs and/or the MMR vaccine to rhesus macaques does not result in neuropathological abnormalities, or aberrant behaviors, like those observed in ASD.

  15. [Integrated sustainability-oriented reporting--key indicators for communities and cities. Results of a research and development project].

    PubMed

    Süss, W; Glismann, W; Trojan, A

    2005-02-01

    In our research project -- supported by the German Federal Ministry for Education and Research (BMBF) - 35 key indicators were developed in an ongoing process in co-operation with 10 East German cities, which are all members in the German cities healthy network. With these indicators the cities should take up integrated sustainability - oriented health reporting, from which actions and projects for health promotion and prevention can be derived. The conceptual background for the research project and the reports to be made by the project in co-operation with the cities, are the three policy programmes that to be realised on a county level: Healthy Cities, Local Agenda 21 and the German city development programme "Soziale Stadt (socially oriented city)". The common goal of these programmes is the sustainable improvement of the quality of life in the counties. The project is part of the BMBF-supported research field "problem - oriented regional reporting systems", in which other projects are involved which are mainly being conducted in the newly-formed East German "Lander". In this article we describe the co-operative process of the development of the indicators. A synopsis of already applied or proposed sets of indicators for municipal reporting was the basis for the development of the project's set of 35 key indicators. The set of indicators is presented according to its usefulness for planning and realisation of actions for health promotion on county level. For each of the 35 indicators a meta - data description was made to support the counties and cities in our project for health reporting. These indicator profiles are also helpful and supportive for all counties and citiesaiming at such health reporting. The project started in May 2002 and lasts till Mai 2005, so that most reports should be completed in the spring of 2005.

  16. Glutathione deficiency in Gclm null mice results in complex I inhibition and dopamine depletion following paraquat administration.

    PubMed

    Liang, Li-Ping; Kavanagh, Terrance J; Patel, Manisha

    2013-08-01

    Depletion of glutathione has been shown to occur in autopsied brains of patients with Parkinson's disease (PD) and in animal models of PD. The goal of this study was to determine whether chronic glutathione (GSH) deficiency per se resulted in complex I inhibition and/or dopamine depletion and whether these indices were further potentiated by aging or administration of paraquat, a redox-cycling herbicide that produces a PD-like neurodegeneration model in rodents (Brooks, A. I., Chadwick, C. A., Gelbard, H. A., Cory-Slechta, D. A., and Federoff, H. J. [1999]. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res. 823, 1-10; McCormack, A. L., Thiruchelvam, M., Manning-Bog, A. B., Thiffault, C., Langston, J. W., Cory-Slechta, D. A., and Di Monte, D. A. [2002]. Environmental risk factors and Parkinson's disease: Selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol. Dis. 10, 119-127.) Deletion of the rate-limiting GSH synthesis gene, glutamate-cysteine ligase modifier subunit (Gclm), leads to significantly lower GSH concentrations in all tissues including brain. Gclm null (Gclm (-/-)) mice provide a model of prolonged GSH depletion to explore the relationship between GSH, complex I inhibition, and dopamine loss in vivo. Despite ~60% depletion of brain GSH in Gclm (-/-) mice of ages 3-5 or 14-16 months, striatal complex I activity, dopamine levels, 3-nitrotyroine/tyrosine ratios, aconitase activity, and CoASH remained unchanged. Administration of paraquat (10mg/kg, twice/week, 3 weeks) to 3- to 5-month-old Gclm (-/-) mice resulted in significantly decreased aconitase activity, complex I activity, and dopamine levels but not in 3- to 5-month-old Gclm (+/+) mice. Furthermore, paraquat-induced inhibition of complex I and aconitase activities in Gclm (-/-) mice was observed in the striatum but not in the cortex. The results suggest that chronic deficiency of GSH in Gclm (-/-) mice was not

  17. U.S. Food and Drug Administration inspections of clinical investigators: overview of results from 1977 to 2009.

    PubMed

    Morgan-Linnell, Sonia K; Stewart, David J; Kurzrock, Razelle

    2014-07-01

    The U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research is responsible for evaluating drug safety and efficacy, including oversight of clinical trials and principal investigators. The FDA Clinical Investigator Inspection List (CIIL) contains online, detailed, relevant information of all FDA inspections. We reviewed FDA inspections of clinical investigators to ascertain their outcome and included all inspections on the list (July 1977 through December 31, 2009; n = 9,481 inspections). Eighty-eight percent of inspections were "data audit" (primary purpose = verification of data), and the rest (12%) were "for cause." The number of inspections each year significantly increased over time (P < 0.0001) and averaged 350 per year in the past decade. No deficiencies were found in only 11.2% of all "data audit" and 5% of all "for cause" inspections. Only 31% of inspections resulted in "no action indicated." About two thirds of inspections resulted in some finding, requiring either voluntary investigator action (61.3% of inspections) or official FDA action (3.9%). The most frequently cited deficiencies were failure to follow investigational plan (34%), inadequate informed consent form (28%), and inadequate/inaccurate records (27%). In conclusion, over the past decade, the FDA has performed approximately 350 inspections per year, with the number increasing over time. The vast majority of FDA inspections yield deficiency findings and, as a result, only about one third of inspections have an outcome of "no action indicated."

  18. 78 FR 9364 - Certain Pasta From Italy: Notice of Final Results of 15th Antidumping Duty Administrative Review...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... Administration, International Trade Administration, Department of Commerce. SUMMARY: The Department of Commerce... mandatory respondents, Pastificio Attilio Mastromauro Granoro S.r.L. (Granoro), and Rummo S.p.A. Molino...

  19. Side-by-Side Comparison of Child Care and Early Education Provisions in Key Senate, House, and Administration Bills and Proposals.

    ERIC Educational Resources Information Center

    Mezey, Jennifer; Schumacher, Rachel; Rakpraja, Tanya; Irish, Kate

    This document summarizes and compares selected child care and early education provisions in current law and a set of major Congressional proposals addressing reauthorization and early education as of September 24, 2002: (1) the Administration's Early Childhood Initiative; (2) the final TANF reauthorization bill as passed in the House; (3) the…

  20. The Integration Process for Incorporating Nuclear Explosion Monitoring Research Results into the National Nuclear Security Administration Knowledge Base

    SciTech Connect

    GALLEGOS, DAVID P.; CARR, DORTHE B.; HERRINGTON, PRESTON B.; HARRIS, JAMES M.; EDWARDS, C.L.; TAYLOR, STEVEN R.; WOGMAN, NED A.; ANDERSON, DALE N.; CASEY, LESLIE A.

    2002-09-01

    The process of developing the National Nuclear Security Administration (NNSA) Knowledge Base (KB) must result in high-quality Information Products in order to support activities for monitoring nuclear explosions consistent with United States treaty and testing moratoria monitoring missions. The validation, verification, and management of the Information Products is critical to successful scientific integration, and hence, will enable high-quality deliveries to be made to the United States National Data Center (USNDC) at the Air Force Technical Applications Center (AFTAC). As an Information Product passes through the steps necessary to become part of a delivery to AFTAC, domain experts (including technical KB Working Groups that comprise NNSA and DOE laboratory staff and the customer) will provide coordination and validation, where validation is the determination of relevance and scientific quality. Verification is the check for completeness and correctness, and will be performed by both the Knowledge Base Integrator and the Scientific Integrator with support from the Contributor providing two levels of testing to assure content integrity and performance. The Information Products and their contained data sets will be systematically tracked through the integration portion of their life cycle. The integration process, based on lessons learned during its initial implementations, is presented in this report.

  1. Power Beamed Photon Sails: New Capabilities Resulting From Recent Maturation Of Key Solar Sail And High Power Laser Technologies

    SciTech Connect

    Montgomery, Edward E. IV

    2010-05-06

    This paper revisits some content in the First International Symposium on Beamed Energy Propulsion in 2002 related to the concept of propellantless in-space propulsion utilizing an external high energy laser to provide momentum to an ultralightweight (gossamer) spacecraft. The design and construction of the NanoSail-D solar sail demonstration spacecraft has demonstrated in space flight hardware the concept of small, very light--yet capable--spacecraft. The results of the Joint High Power Solid State Laser (JHPSSL) have also increased the effectiveness and reduced the cost of an entry level laser source. This paper identifies the impact from improved system parameters on current mission applications.

  2. DIPPER project 871 determination of ideal-gas enthalpies of formation for key compounds, The 1991 project results

    SciTech Connect

    Steele, W.V.; Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Tasker, I.R.

    1993-09-01

    Results of a study aimed at improving group-contribution methodology for estimating thermodynamic properties of organic substances are reported. Specific weaknesses where particular group-contribution terms were unknown, or estimated because of lack of experimental data, are addressed by experimental studies of enthalpies of combustion in condensed phase, vapor-pressure measurements, and differential scanning calorimetric (d.s.c.) heat-capacity measurements. Ideal-gas enthalpies of formation of cyclohexene, phthalan (2,5-dihydrobenzo-3,4-furan), isoxazole, n-octylamine, di-n-octylamine, tri-n-octylamine, phenyl isocyanate, and 1,4,5,6-tetrahydropyrimidine are reported. Two-phase (liquid + vapor) heat capacities were determined for phthalan, isoxazole, the three octylamines, and phenyl isocyanate. Liquid-phase densities along the saturation line were measured for phthalan and isoxazole at 298 to 425 K. The critical temperature and critical density of n-octylamine were determined from d.s.c. results and critical pressure derived from the fitting procedures. Fitting procedures were used to derive critical temperatures, pressures, and densities for cyclohexene (pressure and density only), phthalan, isoxazole, di-n-octylamine, and phenyl isocyanate. Group-additivity parameters or ring-correction terms are derived.

  3. SolarSyngas: Results from a virtual institute developing materials and key components for solar thermochemical fuel production

    NASA Astrophysics Data System (ADS)

    Roeb, Martin; Steinfeld, Aldo; Borchardt, Günter; Feldmann, Claus; Schmücker, Martin; Sattler, Christian; Pitz-Paal, Robert

    2016-05-01

    The Helmholtz Virtual Institute (VI) SolarSynGas brings together expertise from solar energy research and materials science to develop metal oxide based redox materials and to integrate them in a suitable way into related process technologies for two-step thermochemical production of hydrogen and carbon monoxide from water and CO2. One of the foci of experimental investigation was exploring the impact of doping on the feasibility of ceria-based materials - mainly by Zr-doping. The results indicate that a certain Zr-content enhances the reducibility and therefore the splitting performance. Increasing the Zr-content to x = 0.15 improved the specific CO2-splitting performance by 50% compared to pure ceria. This finding agrees with theoretical studies attributing the improvements to lattice modification caused by the introduction of Zr4+. Thermogravimetric relaxation experiments and equilibrium oxygen isotope exchange experiments with subsequent depth profiling analysis were carried out on ceria. As a result the reduction reaction of even dense samples of pure ceria with a grain size of about 20 µm is surface reaction controlled. The structure of the derived expression for the apparent activation energy suggests that the chemical surface exchange coefficient should show only a very weak dependence on temperature for ceria doped with lower valence cations. A solar receiver reactor exhibiting a foam-type reticulated porous ceramics made of ceria was tested. It could be shown that applying dual-scale porosity to those foams with mm-size pores for effective radiative heat transfer during reduction and μm-size pores within its struts for enhanced kinetics during oxidation allows enhancing the performance of the reactor significantly. Also a particle process concept applying solid-solid heat recovery from redox particles in a high temperature solar thermochemical process was analysed that uses ceramic spheres as solid heat transfer medium. This concept can be implemented

  4. Key Findings from Preclinical and Clinical Drug Interaction Studies Presented in New Drug and Biological License Applications Approved by the Food and Drug Administration in 2014.

    PubMed

    Yu, Jingjing; Ritchie, Tasha K; Zhou, Zhu; Ragueneau-Majlessi, Isabelle

    2016-01-01

    Regulatory approval documents contain valuable information, often not published, to assess the drug-drug interaction (DDI) profile of newly marketed drugs. This analysis aimed to systematically review all drug metabolism, transport, pharmacokinetics, and DDI data available in the new drug applications and biologic license applications approved by the U.S. Food and Drug Administration in 2014, using the University of Washington Drug Interaction Database, and to highlight the significant findings. Among the 30 new drug applications and 11 biologic license applications reviewed, 35 new molecular entities (NMEs) were well characterized with regard to drug metabolism, transport, and/or organ impairment and were fully analyzed in this review. In vitro, a majority of the NMEs were found to be substrates or inhibitors/inducers of at least one drug metabolizing enzyme or transporter. In vivo, when NMEs were considered as victim drugs, 16 NMEs had at least one in vivo DDI study with a clinically significant change in exposure (area under the time-plasma concentration curve or Cmax ratio ≥2 or ≤0.5), with 6 NMEs shown to be sensitive substrates of cytochrome P450 enzymes (area under the time-plasma concentration curve ratio ≥5 when coadministered with potent inhibitors): paritaprevir and naloxegol (CYP3A), eliglustat (CYP2D6), dasabuvir (CYP2C8), and tasimelteon and pirfenidone (CYP1A2). As perpetrators, seven NMEs showed clinically significant inhibition involving both enzymes and transporters, although no clinically significant induction was observed. Physiologically based pharmacokinetic modeling and pharmacogenetics studies were used for six and four NMEs, respectively, to optimize dosing recommendations in special populations and/or multiple impairment situations. In addition, the pharmacokinetic evaluations in patients with hepatic or renal impairment provided useful quantitative information to support drug administration in these fragile populations.

  5. 77 FR 19619 - Notice of Extension of Time Limit for the Preliminary Results of Administrative Review of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-02

    ... Administrative Review of the Suspension Agreement on Hot-Rolled Flat- Rolled Carbon-Quality Steel Products from... Review of the Suspension Agreement on Hot-Rolled Flat-Rolled Carbon-Quality Steel Products from the... Investigation on Hot-Rolled Flat-Rolled Carbon-Quality Steel Products from the Russian Federation (the...

  6. Job Interviews: Keys for Results

    ERIC Educational Resources Information Center

    Miller, Donald S.; Catt, Stephen E.; Slocombe, Thomas E.

    2014-01-01

    Many students seem disinterested in learning to handle employment interviews effectively. This article discusses students' motivation to become skilled interviewees and steps educators and counselors can take to increase students' interest in this crucial career activity. The article also discusses mistakes students frequently make during…

  7. How Cannabis Causes Paranoia: Using the Intravenous Administration of ∆9-Tetrahydrocannabinol (THC) to Identify Key Cognitive Mechanisms Leading to Paranoia

    PubMed Central

    Freeman, Daniel; Dunn, Graham; Murray, Robin M.; Evans, Nicole; Lister, Rachel; Antley, Angus; Slater, Mel; Godlewska, Beata; Cornish, Robert; Williams, Jonathan; Di Simplicio, Martina; Igoumenou, Artemis; Brenneisen, Rudolf; Tunbridge, Elizabeth M.; Harrison, Paul J.; Harmer, Catherine J.; Cowen, Philip; Morrison, Paul D.

    2015-01-01

    Paranoia is receiving increasing attention in its own right, since it is a central experience of psychotic disorders and a marker of the health of a society. Paranoia is associated with use of the most commonly taken illicit drug, cannabis. The objective was to determine whether the principal psychoactive ingredient of cannabis—∆9-tetrahydrocannabinol (THC)—causes paranoia and to use the drug as a probe to identify key cognitive mechanisms underlying paranoia. A randomized, placebo-controlled, between-groups test of the effects of intravenous THC was conducted. A total of 121 individuals with paranoid ideation were randomized to receive placebo, THC, or THC preceded by a cognitive awareness condition. Paranoia was assessed extensively via a real social situation, an immersive virtual reality experiment, and standard self-report and interviewer measures. Putative causal factors were assessed. Principal components analysis was used to create a composite paranoia score and composite causal variables to be tested in a mediation analysis. THC significantly increased paranoia, negative affect (anxiety, worry, depression, negative thoughts about the self), and a range of anomalous experiences, and reduced working memory capacity. The increase in negative affect and in anomalous experiences fully accounted for the increase in paranoia. Working memory changes did not lead to paranoia. Making participants aware of the effects of THC had little impact. In this largest study of intravenous THC, it was definitively demonstrated that the drug triggers paranoid thoughts in vulnerable individuals. The most likely mechanism of action causing paranoia was the generation of negative affect and anomalous experiences. PMID:25031222

  8. How cannabis causes paranoia: using the intravenous administration of ∆9-tetrahydrocannabinol (THC) to identify key cognitive mechanisms leading to paranoia.

    PubMed

    Freeman, Daniel; Dunn, Graham; Murray, Robin M; Evans, Nicole; Lister, Rachel; Antley, Angus; Slater, Mel; Godlewska, Beata; Cornish, Robert; Williams, Jonathan; Di Simplicio, Martina; Igoumenou, Artemis; Brenneisen, Rudolf; Tunbridge, Elizabeth M; Harrison, Paul J; Harmer, Catherine J; Cowen, Philip; Morrison, Paul D

    2015-03-01

    Paranoia is receiving increasing attention in its own right, since it is a central experience of psychotic disorders and a marker of the health of a society. Paranoia is associated with use of the most commonly taken illicit drug, cannabis. The objective was to determine whether the principal psychoactive ingredient of cannabis-∆(9)-tetrahydrocannabinol (THC)-causes paranoia and to use the drug as a probe to identify key cognitive mechanisms underlying paranoia. A randomized, placebo-controlled, between-groups test of the effects of intravenous THC was conducted. A total of 121 individuals with paranoid ideation were randomized to receive placebo, THC, or THC preceded by a cognitive awareness condition. Paranoia was assessed extensively via a real social situation, an immersive virtual reality experiment, and standard self-report and interviewer measures. Putative causal factors were assessed. Principal components analysis was used to create a composite paranoia score and composite causal variables to be tested in a mediation analysis. THC significantly increased paranoia, negative affect (anxiety, worry, depression, negative thoughts about the self), and a range of anomalous experiences, and reduced working memory capacity. The increase in negative affect and in anomalous experiences fully accounted for the increase in paranoia. Working memory changes did not lead to paranoia. Making participants aware of the effects of THC had little impact. In this largest study of intravenous THC, it was definitively demonstrated that the drug triggers paranoid thoughts in vulnerable individuals. The most likely mechanism of action causing paranoia was the generation of negative affect and anomalous experiences.

  9. Combined administration of kanamycin and furosemide does not result in loss of vestibular function in Guinea pigs.

    PubMed

    Bremer, Hendrik G; de Groot, John C M J; Versnel, Huib; Klis, Sjaak F L

    2012-01-01

    Aminoglycoside antibiotics are known to damage the vestibular and auditory sensory epithelia. Although loop diuretics enhance the cochleotoxic effect of aminoglycosides, it is not known whether concomitant administration of an aminoglycoside and a loop diuretic affects the vestibular system. The aim of our study was to investigate the effect of co-administration of kanamycin and furosemide upon the otolith organs and to compare it to the known vestibulotoxic effect of gentamicin. Five guinea pigs were injected with a single dose of both kanamycin (400 mg/kg, s.c.) and furosemide (100 mg/kg, i.v.), 5 animals received gentamicin (100 mg/kg, i.p.) for 10 days, and 5 untreated animals served as controls. After 7 days, vestibular function was assessed by measuring vestibular short-latency evoked potentials (VsEPs) to linear acceleration stimuli and cochlear function by auditory brainstem responses (ABRs) to clicks. Hair cell densities were determined in phalloidin-stained whole mounts of the utricles and saccules, and in midmodiolar sections of resin-embedded cochleae. Co-administration of kanamycin and furosemide had no significant effect on VsEPs and hair cell densities in the utricles and saccules were not reduced. ABR thresholds were increased to a great extent (by ∼60 dB), and histologically a severe loss of cochlear hair cells was observed. The effect of gentamicin, both on vestibular and cochlear function, was just the opposite. VsEP thresholds to horizontal stimulation were elevated and suprathreshold amplitudes showed a decrease, whereas cochlear function was not reduced. With this protocol, we have a tool to selectively induce cochlear or vestibular damage, which may be of interest to researchers and clinicians alike.

  10. Patient-centered medical home initiative produced modest economic results for Veterans Health Administration, 2010-12.

    PubMed

    Hebert, Paul L; Liu, Chuan-Fen; Wong, Edwin S; Hernandez, Susan E; Batten, Adam; Lo, Sophie; Lemon, Jaclyn M; Conrad, Douglas A; Grembowski, David; Nelson, Karin; Fihn, Stephan D

    2014-06-01

    In 2010 the Veterans Health Administration (VHA) began a nationwide initiative called Patient Aligned Care Teams (PACT) that reorganized care at all VHA primary care clinics in accordance with the patient-centered medical home model. We analyzed data for fiscal years 2003-12 to assess how trends in health care use and costs changed after the implementation of PACT. We found that PACT was associated with modest increases in primary care visits and with modest decreases in both hospitalizations for ambulatory care-sensitive conditions and outpatient visits with mental health specialists. We estimated that these changes avoided $596 million in costs, compared to the investment in PACT of $774 million, for a potential net loss of $178 million in the study period. Although PACT has not generated a positive return, it is still maturing, and trends in costs and use are favorable. Adopting patient-centered care does not appear to have been a major financial risk for the VHA.

  11. Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: results of an in vitro and in vivo study.

    PubMed

    Zheng, Fang; Shi, Xiao-Wen; Yang, Gui-Fang; Gong, Ling-Ling; Yuan, Hong-Yin; Cui, Ye-Jian; Wang, Yan; Du, Yu-Min; Li, Yan

    2007-01-02

    This study was designed to investigate the in vitro and in vivo transfection efficiency of chitosan nanoparticles used as vectors for gene therapy. Three types of chitosan nanoparticles [quaternized chitosan -60% trimethylated chitosan oligomer (TMCO-60%), C(43-45 KDa, 87%), and C(230 KDa, 90%)] were used to encapsulate plasmid DNA (pDNA) encoding green fluorescent protein (GFP) using the complex coacervation technique. The morphology, optimal chitosan-pDNA binding ratio and conditions for maximal in vitro transfection were studied. The in vivo transfection was conducted by feeding the chitosan/pDNA nanoparticles to 12 BALB/C-nu/nu nude mice. Both conventional and TMCO-60% could form stable nanoparticles with pDNA. The in vitro study showed the transfection efficiency to be in the following descending order: TMCO-60%>C(43-45 KDa, 87%)>C(230 KDa, 90%). TMCO-60% proved to be the most efficient and the optimal chitosan/pDNA ratio being 3.2:1. In vivo study showed most prominent GPF expression in the gastric and upper intestinal mucosa. GFP expression in the mucosa of the stomach and duodenum, jejunum, ileum, and large intestine were found, respectively, in 100%, 88.9%, 77.8% and 66.7% of the nude mice examined. TMCO-60%/pDNA nanoparticles had better in vitro and in vivo transfection activity than the other two, and with minimal toxicity, which made it a desirable non-viral vector for gene therapy via oral administration.

  12. Thallium-201 myocardial imaging after pharmacologic coronary vasodilation: Preliminary results of a comparison between oral and intravenous administration of dipyridamole

    SciTech Connect

    Taillefer, R.; Lette, J.; Phaneuf, D.C.; Lemire, F.; Leveille, J.

    1985-05-01

    Although the diagnostic utility of Tl-201 myocardial imaging after dipyridamole (DIP) infusion is well established, the intravenous form of the drug is not commercially available. The author prospectively studied 34 consecutive patients referred for coronary angiography. With in a 2 week period, each patient underwent cardiac catheterization and Tl-201 myocardial imaging following both oral and i.v. DIP. With the patient supine, DIP was infused at a rate of 0.56 mg/kg over 4 minutes. Tl-201 was injected 3 min. after the end of the infusion with the patient standing. Myocardial imaging was performed in 3 views at 3 min. and 4 hrs after Tl-201 injection. All patients were then randomized to either 200 mg or 400 mg of oral DIP. Imaging protocol was similar to the i.v. technique, except for a delay of 45-60 min. before Tl-201 injection. Myocardial regional perfusion was evaluated by 2 independent observers using original analog and background substracted digital images with segmental profile analysis. For the 17 patients who recieved DIP 400 mg, the sensitivity was 75%(9/12) with the infusion and 83% (10/12) with the oral dose. Side effects were minor and less frequent with the oral DIP. Despite the small number of patients studied, Tl-201 imaging following 400 mg oral DIP administration proved to be reliable alternative to the intravenously induced coronary vasodilation.

  13. Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate

    SciTech Connect

    Triguero, D.; Buciak, J.L.; Pardridge, W.M. )

    1991-07-01

    Cationization of proteins in general enhances the cellular uptake of these macromolecules, and cationized antibodies are known to retain antigen binding properties. Therefore, cationized antibodies may be therapeutic and allow for intracellular immunization. The present studies test the hypothesis that the tissue uptake of cationized immunoglobulin G (IgG) after intravenous administration may be greatly increased relative to the uptake of native proteins. The pharmacokinetics of cationized immunoglobulin G clearance from blood, and the volume of distribution of the cationized or native protein (albumin, IgG) for 10 organs was measured both in anesthetized rats and in an anesthetized adult Macaca irus cynomologous monkey. Initial studies on brain showed that serum factors inhibited uptake of 125I-cationized IgG, but not 3H-cationized IgG. The blood-brain barrier permeability surface area product for 3H-cationized IgG was 0.57 {plus minus} 0.04 microliters min-1 g-1. The ratio of the volume of distribution of the 3-H-cationized IgG compared to 3H-labeled native albumin ranged from 0.9 (testis) to 15.7 (spleen) in the rat at 3 hr after injection, and a similarly enhanced organ uptake was observed in the primate. In conclusion, these studies demonstrate that cationization of immunoglobulin greatly increases organ uptake of the plasma protein compared to native immunoglobulins, and suggest that cationization of monoclonal antibodies may represent a potential new strategy for enhancing the intracellular delivery of these proteins.

  14. A mental health needs assessment of children and adolescents in post-conflict Liberia: results from a quantitative key-informant survey

    PubMed Central

    Borba, Christina P.C.; Ng, Lauren C.; Stevenson, Anne; Vesga-Lopez, Oriana; Harris, Benjamin L.; Parnarouskis, Lindsey; Gray, Deborah A.; Carney, Julia R.; Domínguez, Silvia; Wang, Edward K.S.; Boxill, Ryan; Song, Suzan J.; Henderson, David C.

    2016-01-01

    Between 1989 and 2004, Liberia experienced a devastating civil war that resulted in widespread trauma with almost no mental health infrastructure to help citizens cope. In 2009, the Liberian Ministry of Health and Social Welfare collaborated with researchers from Massachusetts General Hospital to conduct a rapid needs assessment survey in Liberia with local key informants (n = 171) to examine the impact of war and post-war events on emotional and behavioral problems of, functional limitations of, and appropriate treatment settings for Liberian youth aged 5–22. War exposure and post-conflict sexual violence, poverty, infectious disease and parental death negatively impacted youth mental health. Key informants perceived that youth displayed internalizing and externalizing symptoms and mental health-related functional impairment at home, school, work and in relationships. Medical clinics were identified as the most appropriate setting for mental health services. Youth in Liberia continue to endure the harsh social, economic and material conditions of everyday life in a protracted post-conflict state, and have significant mental health needs. Their observed functional impairment due to mental health issues further limited their access to protective factors such as education, employment and positive social relationships. Results from this study informed Liberia's first post-conflict mental health policy. PMID:26807147

  15. A mental health needs assessment of children and adolescents in post-conflict Liberia: results from a quantitative key-informant survey.

    PubMed

    Borba, Christina P C; Ng, Lauren C; Stevenson, Anne; Vesga-Lopez, Oriana; Harris, Benjamin L; Parnarouskis, Lindsey; Gray, Deborah A; Carney, Julia R; Domínguez, Silvia; Wang, Edward K S; Boxill, Ryan; Song, Suzan J; Henderson, David C

    2016-01-02

    Between 1989 and 2004, Liberia experienced a devastating civil war that resulted in widespread trauma with almost no mental health infrastructure to help citizens cope. In 2009, the Liberian Ministry of Health and Social Welfare collaborated with researchers from Massachusetts General Hospital to conduct a rapid needs assessment survey in Liberia with local key informants (n = 171) to examine the impact of war and post-war events on emotional and behavioral problems of, functional limitations of, and appropriate treatment settings for Liberian youth aged 5-22. War exposure and post-conflict sexual violence, poverty, infectious disease and parental death negatively impacted youth mental health. Key informants perceived that youth displayed internalizing and externalizing symptoms and mental health-related functional impairment at home, school, work and in relationships. Medical clinics were identified as the most appropriate setting for mental health services. Youth in Liberia continue to endure the harsh social, economic and material conditions of everyday life in a protracted post-conflict state, and have significant mental health needs. Their observed functional impairment due to mental health issues further limited their access to protective factors such as education, employment and positive social relationships. Results from this study informed Liberia's first post-conflict mental health policy.

  16. Quantification of key long-term risks at CO₂ sequestration sites: Latest results from US DOE's National Risk Assessment Partnership (NRAP) Project

    DOE PAGES

    Pawar, Rajesh; Bromhal, Grant; Carroll, Susan; ...

    2014-12-31

    Risk assessment for geologic CO₂ storage including quantification of risks is an area of active investigation. The National Risk Assessment Partnership (NRAP) is a US-Department of Energy (US-DOE) effort focused on developing a defensible, science-based methodology and platform for quantifying risk profiles at geologic CO₂ sequestration sites. NRAP has been developing a methodology that centers round development of an integrated assessment model (IAM) using system modeling approach to quantify risks and risk profiles. The IAM has been used to calculate risk profiles with a few key potential impacts due to potential CO₂ and brine leakage. The simulation results are alsomore » used to determine long-term storage security relationships and compare the long-term storage effectiveness to IPCC storage permanence goal. Additionally, we also demonstrate application of IAM for uncertainty quantification in order to determine parameters to which the uncertainty in model results is most sensitive.« less

  17. Quantification of key long-term risks at CO₂ sequestration sites: Latest results from US DOE's National Risk Assessment Partnership (NRAP) Project

    SciTech Connect

    Pawar, Rajesh; Bromhal, Grant; Carroll, Susan; Chu, Shaoping; Dilmore, Robert; Gastelum, Jason; Oldenburg, Curt; Stauffer, Philip; Zhang, Yingqi; Guthrie, George

    2014-12-31

    Risk assessment for geologic CO₂ storage including quantification of risks is an area of active investigation. The National Risk Assessment Partnership (NRAP) is a US-Department of Energy (US-DOE) effort focused on developing a defensible, science-based methodology and platform for quantifying risk profiles at geologic CO₂ sequestration sites. NRAP has been developing a methodology that centers round development of an integrated assessment model (IAM) using system modeling approach to quantify risks and risk profiles. The IAM has been used to calculate risk profiles with a few key potential impacts due to potential CO₂ and brine leakage. The simulation results are also used to determine long-term storage security relationships and compare the long-term storage effectiveness to IPCC storage permanence goal. Additionally, we also demonstrate application of IAM for uncertainty quantification in order to determine parameters to which the uncertainty in model results is most sensitive.

  18. 78 FR 9672 - Certain Pasta From Turkey; 2010-2011; Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... Issues and Decision Memorandum, Preliminary Results, and Memorandum to Melissa Skinner, Office Director... Bellini/Marsan \\7\\ 0.00 Disclosure In accordance with 19 CFR 351.224(b), we will disclose calculation... (the Act), and 19 CFR 351.212(b), the Department will determine, and CBP shall assess,...

  19. 76 FR 56401 - Stainless Steel Bar from India: Final Results of the Antidumping Duty Administrative Review, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    .... (``Facor''), Mukand Ltd. (``Mukand''), and Venus Wire Industries Pvt. Ltd. (``Venus Wire'').\\1\\ Based on... explained in the Preliminary Results, we have determined that Venus Wire and its affiliates, Hindustan Inox... and Austin Redington to the File, ``Whether to Collapse Venus Wire Industries Pvt., Ltd. and...

  20. 77 FR 64100 - Glycine from the People's Republic of China: Final Results of Antidumping Duty Administrative Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-18

    ... calculation with respect to the sole company subject to this review, Baoding Mantong Fine Chemistry Co. Ltd...-Calculation Program for Baoding Mantong Fine Chemistry Co., Ltd.'' (Revised Preliminary Results). FOR FURTHER..., 2011: Margin Exporter (percent) Baoding Mantong Fine Chemistry Co., Ltd 453.79 Assessment...

  1. 77 FR 70417 - Administrative Review of Honey From the People's Republic of China: Final Results of Antidumping...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... exporter listed above, the cash deposit rate will be established in the final results of this review (except, if the rate is zero or de minimis, i.e., less than 0.5 percent, no cash deposit will be required... above that have separate rates, the cash deposit rate will continue to be the exporter-specific...

  2. Shift Work in Rats Results in Increased Inflammatory Response after Lipopolysaccharide Administration: A Role for Food Consumption.

    PubMed

    Guerrero-Vargas, Natalí N; Guzmán-Ruiz, Mara; Fuentes, Rebeca; García, Joselyn; Salgado-Delgado, Roberto; Basualdo, María del Carmen; Escobar, Carolina; Markus, Regina P; Buijs, Ruud M

    2015-08-01

    The suprachiasmatic nucleus (SCN) drives circadian rhythms in behavioral and physiological variables, including the inflammatory response. Shift work is known to disturb circadian rhythms and is associated with increased susceptibility to develop disease. In rodents, circadian disruption due to shifted light schedules (jet lag) induced increased innate immune responses. To gain more insight into the influence of circadian disruption on the immune response, we characterized the inflammatory response in a model of rodent shift work and demonstrated that circadian disruption affected the inflammatory response to lipopolysaccharide (LPS) both in vivo and in vitro. Since food consumption is a main disturbing element in the shift work schedule, we also evaluated the inflammatory response to LPS in a group of rats that had no access to food during their working hours. Our results demonstrated that the shift work schedule decreased basal TNF-α levels in the liver but not in the circulation. Despite this, we observed that shift work induced increased cytokine response after LPS stimulation in comparison to control rats. Also, Kupffer cells (liver macrophages) isolated from shift work rats produced more TNF-α in response to in vitro LPS stimulation, suggesting important effects of circadian desynchronization on the functionality of this cell type. Importantly, the effects of shift work on the inflammatory response to LPS were prevented when food was not available during the working schedule. Together, these results show that dissociating behavior and food intake from the synchronizing drive of the SCN severely disturbs the immune response.

  3. Nurses and opioids: results of a bi-national survey on mental models regarding opioid administration in hospitals

    PubMed Central

    Guest, Charlotte; Sobotka, Fabian; Karavasopoulou, Athina; Ward, Stephen; Bantel, Carsten

    2017-01-01

    Objective Pain remains insufficiently treated in hospitals. Increasing evidence suggests human factors contribute to this, due to nurses failing to administer opioids. This behavior might be the consequence of nurses’ mental models about opioids. As personal experience and conceptions shape these models, the aim of this prospective survey was to identify model-influencing factors. Material and methods A questionnaire was developed comprising of 14 statements concerning ideations about opioids and seven questions concerning demographics, indicators of adult learning, and strength of religious beliefs. Latent variables that may underlie nurses’ mental models were identified using undirected graphical dependence models. Representative items of latent variables were employed for ordinal regression analysis. Questionnaires were distributed to 1,379 nurses in two London, UK, hospitals (n=580) and one German (n=799) hospital between September 2014 and February 2015. Results A total of 511 (37.1%) questionnaires were returned. Mean (standard deviation) age of participants were 37 (11) years; 83.5% participants were female; 45.2% worked in critical care; and 51.5% had more than 10 years experience. Of the nurses, 84% were not scared of opioids, 87% did not regard opioids as drugs to help patients die, and 72% did not view them as drugs of abuse. More English (41%) than German (28%) nurses were afraid of criminal investigations and were constantly aware of side effects (UK, 94%; Germany, 38%) when using opioids. Four latent variables were identified which likely influence nurses’ mental models: “conscious decision-making”; “medication-related fears”; “practice-based observations”; and “risk assessment”. They were predicted by strength of religious beliefs and indicators of informal learning such as experience but not by indicators of formal learning such as conference attendance. Conclusion Nurses in both countries employ analytical and affective mental

  4. Key results of the mini-dome Fresnel lens concentrator array development program under recently completed NASA and SDIO SBIR projects

    NASA Technical Reports Server (NTRS)

    Oneill, Mark J.; Piszczor, Michael F.; Fraas, Lewis M.

    1991-01-01

    Since 1986, ENTECH and the NASA Lewis Research Center have been developing a new photovoltaic concentrator system for space power applications. The unique refractive system uses small, dome shaped Fresnel lenses to focus sunlight onto high efficiency photovoltaic concentrator cells which use prismatic cell covers to further increase their performance. Highlights of the five-year development include near Air Mass Zero (AM0) Lear Jet flight testing of mini-dome lenses (90 pct. net optical efficiency achieved); tests verifying sun-pointing error tolerance with negligible power loss; simulator testing of prism-covered GaAs concentrator cells (24 pct. AM0 efficiency); testing of prism-covered Boeing GaAs/GaSb tandem cells (31 pct. AM0 efficiency); and fabrication and outdoor testing of a 36-lens/cell element panel. These test results have confirmed previous analytical predictions which indicate substantial performance improvements for this technology over current array systems. Based on program results to date, it appears than an array power density of 300 watts/sq m and a specific power of 100 watts/kg can be achieved in the near term. All components of the array appear to be readily manufacturable from space-durable materials at reasonable cost. A concise review is presented of the key results leading to the current array, and further development plans for the future are briefly discussed.

  5. Deletion of the carboxyl-terminal region of 1-aminocyclopropane-1-carboxylic acid synthase, a key protein in the biosynthesis of ethylene, results in catalytically hyperactive, monomeric enzyme.

    PubMed

    Li, N; Mattoo, A K

    1994-03-04

    1-Aminocyclopropane-1-carboxylic acid (ACC) synthase is a key enzyme regulating biosynthesis of the plant hormone ethylene. The expression of an enzymatically active, wound-inducible tomato (Lycopersicon esculentum L. cv Pik-Red) ACC synthase (485 amino acids long) in a heterologous Escherichia coli system allowed us to study the importance of hypervariable COOH terminus in enzymatic activity and protein conformation. We constructed several deletion mutants of the gene, expressed these in E. coli, purified the protein products to apparent homogeneity, and analyzed both conformation and enzyme kinetic parameters of the wild-type and truncated ACC syntheses. Deletion of the COOH terminus through Arg429 results in complete inactivation of the enzyme. Deletion of 46-52 amino acids from the COOH terminus results in an enzyme that has nine times higher affinity for the substrate S-adenosylmethionine than the wild-type enzyme. The highly efficient, truncated ACC synthase was found to be a monomer of 52 +/- 1.8 kDa as determined by gel filtration, whereas the wild-type ACC synthase, analyzed under similar conditions, is a dimer. These results demonstrate that the non-conserved COOH terminus of ACC synthase affects its enzymatic function as well as dimerization.

  6. Administrators: Nursing Home Administrator

    ERIC Educational Resources Information Center

    Kahl, Anne

    1976-01-01

    Responsibilities, skills needed, training needed, earnings, employment outlook, and sources of additional information are outlined for the administrator who holds the top management job in a nursing home. (JT)

  7. Results.

    ERIC Educational Resources Information Center

    Zemsky, Robert; Shaman, Susan; Shapiro, Daniel B.

    2001-01-01

    Describes the Collegiate Results Instrument (CRI), which measures a range of collegiate outcomes for alumni 6 years after graduation. The CRI was designed to target alumni from institutions across market segments and assess their values, abilities, work skills, occupations, and pursuit of lifelong learning. (EV)

  8. Nonfatal Suicidal Behaviors in U.S. Army Administrative Records, 2004–2009: Results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)

    PubMed Central

    Ursano, Robert J.; Kessler, Ronald C.; Heeringa, Steven G.; Cox, Kenneth L.; Naifeh, James A.; Fullerton, Carol S.; Sampson, Nancy A.; Kao, Tzu-Cheg; Aliaga, Pablo A.; Vegella, Patti; Mash, Holly Herberman; Buckley, Christina; Colpe, Lisa J.; Schoenbaum, Michael; Stein, Murray B.

    2015-01-01

    Objective Although the U.S. Army suicide rate is known to have risen sharply over the past decade, information about medically documented, nonfatal suicidal behaviors is far more limited. Here we examine trends and sociodemographic correlates of suicide attempts, suspicious injuries, and suicide ideation among regular Army soldiers. Methods Data come from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS) Historical Administrative Data Study (HADS), which integrates administrative records for all soldiers on active duty during the years 2004 through 2009 (n = 1.66 million). Results We identified 21,740 unique regular Army soldiers with a nonfatal suicidal event documented at some point during the HADS study period. There were substantial increases in the annual incidence rates of suicide attempts (179–400/100,000 person-years) and suicide ideation (557–830/100,000 person-years), but not suspicious injuries. Using hierarchical classification rules to identify the first instance of each soldier's most severe behavior, we found increased risk of all outcomes among those who were female, non-Hispanic White, never married, lower-ranking enlisted, less educated, and of younger age when entering Army service. These sociodemographic associations significantly differed across outcomes, despite some patterns that appear similar. Conclusion Results provide a broad overview of nonfatal suicidal trends in the U.S. Army during 2004 through 2009 and demonstrate that integration of multiple administrative data systems enriches analysis of the predictors of such events. PMID:26168022

  9. Impairment of Salivary Mucin Production Resulting in Declined Salivary Viscosity During Naproxen Administration as a Potential Link to Upper Alimentary Tract Mucosal Injury

    PubMed Central

    Garcia, Cesar J; Castro-Combs, Juan; Dias, Ajoy; Alfaro, Rodrigo; Vasallo, Javier; Majewski, Marek; Jaworski, Tom; Wallner, Grzegorz; Sarosiek, Jerzy

    2013-01-01

    OBJECTIVES: Nonsteroidal anti-inflammatory drugs (NSAIDs) contribute to the esophageal mucosal injury through its direct topical impact on the luminal aspect of the surface epithelium. Its indirect, systemic impact, however, on salivary component of the esophageal pre-epithelial barrier remains to be explored. Therefore, salivary mucin secretion and viscosity at baseline and during naproxen-placebo, as well as naproxen-rabeprazole, administration were investigated. METHODS: Twenty-one asymptomatic volunteers were included in this double-blind, placebo-controlled, crossover designed study. Salivary samples were obtained in basal and pentagastrin-stimulated conditions (6 mg/kg s.c.) mimicking the food-stimulated conditions. Patients received 7 days of naproxen-placebo or naproxen-rabeprazole with a 2-week washout period in between. Salivary mucin content and viscosity were measured before and after treatment using periodic acid/Schiff's methodology and Cone/Plate Digital Viscometer, respectively. RESULTS: The rate of salivary mucin secretion in basal condition declined by 32% during administration of naproxen-placebo (11.3±1.7 vs. 16.8±3.3 mg/h). Salivary mucin secretion in pentagastrin-stimulated condition declined significantly (by 34%) during the administration of naproxen-placebo (13.6±1.5 vs. 20.7±3.0 mg/h; P<0.05). Viscosity significantly decreased after naproxen-placebo administration in basal (by 60%) and stimulated conditions (by 56%) (P<0.001). Coadministration of rabeprazole at least partly restored the naproxen-induced decline of salivary mucin in basal condition (by 8%), and pentagastrin-stimulated conditions (by 30%). CONCLUSIONS: A significant decline of salivary mucin and viscosity during administration of naproxen may at least partly explain a propensity of patients on chronic therapy with NSAIDs to the development of esophageal mucosal injury and complications. In addition the trend to restorative capacity of rabeprazole on the

  10. A survey of Lab Tests Online-UK users: a key resource for patients to empower and help them understand their laboratory test results.

    PubMed

    Leyland, Rebecca; Freedman, Danielle B

    2016-11-01

    Background Lab Tests Online-UK celebrated its 10th anniversary in 2014 and to mark the occasion the first comprehensive survey of website users was undertaken. Methods A pop-up box with a link to Survey Monkey was used to offer website users the chance to participate in the survey, which was live from 4 March 2014 to 11 April 2014. Results Six hundred and sixty-one participants started the questionnaire and 338 completed all of the demographic questions. Although the website is designed and aimed at patients and the public, a significant number of respondents were health-care professionals (47%). The majority of survey participants found the Lab Tests Online-UK website via a search engine and were visiting the site for themselves. The majority of participants found what they were looking for on the website and found the information very easy or fairly easy to understand. The patient respondents were keen to see their laboratory test results (87%), but the majority did not have access (60%) at the time of the survey. Conclusions This survey provides good evidence that the Lab Tests Online-UK website is a useful resource for patients and health-care professionals alike. It comes at a poignant time as the release of results direct to patients starts with access to their medical records. The Lab Tests Online-UK website has a key role in enabling patients to understand their lab test results, and therefore empowering them to take an interest and engage in their own healthcare.

  11. Small-scale home composting of biodegradable household waste: overview of key results from a 3-year research programme in West London.

    PubMed

    Smith, Stephen R; Jasim, Sharon

    2009-12-01

    Home composting (HC) is recognized by both local and national Governments for its contribution to reducing household waste disposal in landfill. However, the quantitative impact of HC on the diversion of household waste from landfill is uncertain. An overview of key results is presented from a 3-year research programme on HC in the West London area of Runnymede Borough Council (RBC), Surrey, UK. The amount of biodegradable household waste diverted from landfill disposal by HC was measured in a 2-year monitoring study involving 64 homeowners. The total average annual waste input to a standard 290 L HC bin was approximately 370 kg per household. The average relative mass inputs of kitchen, paper and garden waste were 29, 2 and 69%, respectively. A survey of the study area indicated that approximately 20% of households were engaged in HC and, based on inputs to HC bins, this corresponded to an overall recycling/diversion rate equivalent to 20% of household biodegradable waste. Temperature and gas composition measurements indicated organic matter decomposition by HC was aerobic and only traces of CH(4) were occasionally detected. A field trial examined the end-use of composted products for the growth of Petunia grandiflora. Flower production increased with home-produced composts in comparison with peat-amended or untreated control soil. Compost chemical composition, bioaerosol emissions and vector attraction were also investigated.

  12. Behavior Change After 20 Months of a Radio Campaign Addressing Key Lifesaving Family Behaviors for Child Survival: Midline Results From a Cluster Randomized Trial in Rural Burkina Faso

    PubMed Central

    Sarrassat, Sophie; Meda, Nicolas; Ouedraogo, Moctar; Some, Henri; Bambara, Robert; Head, Roy; Murray, Joanna; Remes, Pieter; Cousens, Simon

    2015-01-01

    Background: In Burkina Faso, a comprehensive 35-month radio campaign addressed key, multiple family behaviors for improving under-5 child survival and was evaluated using a repeated cross-sectional, cluster randomized design. The primary outcome of the trial was postneonatal under-5 child mortality. This paper reports on behavior change achieved at midline. Method: Fourteen community radio stations in 14 geographic areas were selected based on their high listenership. Seven areas were randomly allocated to receive the intervention while the other 7 areas served as controls. The campaign was launched in March 2012. Cross-sectional surveys of about 5,000 mothers of under-5 children, living in villages close to the radio stations, were conducted at baseline (from December 2011 to February 2012) and at midline (in November 2013), after 20 months of campaigning. Statistical analyses were based on cluster-level summaries using a difference-in-difference (DiD) approach and adjusted for imbalances between arms at baseline. In addition, routine health facility data were analyzed for evidence of changes in health facility utilization. Results: At midline, 75% of women in the intervention arm reported recognizing radio spots from the campaign. There was some evidence of the campaign having positive effects on care seeking for diarrhea (adjusted DiD, 17.5 percentage points; 95% confidence interval [CI], 2.5 to 32.5; P = .03), antibiotic treatment for fast/difficult breathing (adjusted DiD, 29.6 percentage points; 95% CI, 3.5 to 55.7; P = .03), and saving money during pregnancy (adjusted DiD, 12.8 percentage points; 95% CI, 1.4 to 24.2; P = .03). For other target behaviors, there was little or no evidence of an impact of the campaign after adjustment for baseline imbalances and confounding factors. There was weak evidence of a positive correlation between the intensity of broadcasting of messages and reported changes in target behaviors. Routine health facility data

  13. Evaluation of the program to eliminate lymphatic filariasis in Vanuatu following two years of mass drug administration implementation: results and methodologic approach.

    PubMed

    Fraser, Margaret; Taleo, George; Taleo, Fasihah; Yaviong, James; Amos, Morris; Babu, Mark; Kalkoa, Morris

    2005-10-01

    This report presents the results of the Vanuatu mid-term evaluation of the lymphatic filariasis elimination program being implemented countrywide. Vanuatu is one of the first countries to initiate this program as part of the Global Program for Elimination of Lymphatic Filariasis, based on a five-year annual mass drug administration (MDA) of albendazole and diethylcarbamazine and complemented in Vanuatu by extensive coverage with bed nets. This paper reports results of 561 persons tested at eight sentinel sites following two years of MDA. Coverage was 72% and bed net use was more than 70%. Antigen prevalence was reduced by 63% (from 22% to 8%) and prevalence of microfilaremia prevalence was reduced by 93% (from 12% to 0.8%). Results of surveys of health workers and the community are also reported, and the methodology used for this evaluation is discussed.

  14. Failure to Recognize Novelty after Extended Methamphetamine Self-Administration Results from Loss of Long-Term Depression in the Perirhinal Cortex

    PubMed Central

    Scofield, Michael D; Trantham-Davidson, Heather; Schwendt, Marek; Leong, Kah-Chung; Peters, Jamie; See, Ronald E; Reichel, Carmela M

    2015-01-01

    Exposure to methamphetamine (meth) can produce lasting memory impairments in humans and rodents. We recently demonstrated that extended access meth self-administration results in novel object recognition (NOR) memory deficits in rats. Recognition of novelty depends upon intact perirhinal (pRh) cortex function, which is compromised by meth-induced downregulation of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors. NMDA receptors containing this subunit have a critical role in pRh long-term depression (LTD), one of the primary physiological processes thought to underlie object recognition memory. We hypothesized that meth-induced downregulation of GluN2B receptors would compromise pRh LTD, leading to loss of NOR memory. We found that meth self-administration resulted in an inability to induce pRh LTD following 1 Hz stimulation, an effect that was reversed with bath application of the NMDA receptor partial agonist D-cycloserine (DCS). In addition, pRh microinfusion of DCS restored meth-induced memory deficits. Furthermore, blockade of GluN2B-containing NMDA receptors with Ro 25-6981 prevented DCS restoration of pRh LTD in meth subjects. Thus, targeting pRh LTD may be a promising strategy to treat meth-induced cognitive impairment. PMID:25865928

  15. Senior Administrators Should Have Administrative Contracts.

    ERIC Educational Resources Information Center

    Posner, Gary J.

    1987-01-01

    Recognizing that termination is viewed by the employee as the equivalent to capital punishment of a career, an administrative contract can reduce the emotional and financial entanglements that often result. Administrative contracts are described. (MLW)

  16. Tolerance to Ethanol or Nicotine Results in Increased Ethanol Self-Administration and Long-Term Depression in the Dorsolateral Striatum.

    PubMed

    Abburi, Chandrika; Wolfman, Shannon L; Metz, Ryan A E; Kamber, Rinya; McGehee, Daniel S; McDaid, John

    2016-01-01

    Ethanol (EtOH) and nicotine are the most widely coabused drugs. Tolerance to EtOH intoxication, including motor impairment, results in greater EtOH consumption and may result in a greater likelihood of addiction. Previous studies suggest that cross-tolerance between EtOH and nicotine may contribute to the abuse potential of these drugs. Here we demonstrate that repeated intermittent administration of either EtOH or nicotine in adult male Sprague Dawley rats results in tolerance to EtOH-induced motor impairment and increased EtOH self-administration. These findings suggest that nicotine and EtOH cross-tolerance results in decreased aversive and enhanced rewarding effects of EtOH. Endocannabinoid signaling in the dorsolateral striatum (DLS) has been implicated in both EtOH tolerance and reward, so we investigated whether nicotine or EtOH pretreatment might modulate endocannabinoid signaling in this region. Using similar EtOH and nicotine pretreatment methods resulted in increased paired-pulse ratios of evoked EPSCs in enkephalin-positive medium spiny neurons in DLS slices. Thus, EtOH and nicotine pretreatment may modulate glutamatergic synapses in the DLS presynaptically. Bath application of the CB1 receptor agonist Win 55,2-212 increased the paired-pulse ratio of evoked EPSCs in control slices, while Win 55,2-212 had no effect on paired-pulse ratio in slices from either EtOH- or nicotine-pretreated rats. Consistent with these effects, nicotine pretreatment occluded LTD induction by high-frequency stimulation of the corticostriatal inputs to the dorsolateral striatum. These results suggest that nicotine and EtOH pretreatment modulates striatal synapses to induce tolerance to the motor-impairing effects of EtOH, which may contribute to nicotine and EtOH coabuse.

  17. Tolerance to Ethanol or Nicotine Results in Increased Ethanol Self-Administration and Long-Term Depression in the Dorsolateral Striatum

    PubMed Central

    Abburi, Chandrika; Wolfman, Shannon L.; Metz, Ryan A. E.; Kamber, Rinya

    2016-01-01

    Abstract Ethanol (EtOH) and nicotine are the most widely coabused drugs. Tolerance to EtOH intoxication, including motor impairment, results in greater EtOH consumption and may result in a greater likelihood of addiction. Previous studies suggest that cross-tolerance between EtOH and nicotine may contribute to the abuse potential of these drugs. Here we demonstrate that repeated intermittent administration of either EtOH or nicotine in adult male Sprague Dawley rats results in tolerance to EtOH-induced motor impairment and increased EtOH self-administration. These findings suggest that nicotine and EtOH cross-tolerance results in decreased aversive and enhanced rewarding effects of EtOH. Endocannabinoid signaling in the dorsolateral striatum (DLS) has been implicated in both EtOH tolerance and reward, so we investigated whether nicotine or EtOH pretreatment might modulate endocannabinoid signaling in this region. Using similar EtOH and nicotine pretreatment methods resulted in increased paired-pulse ratios of evoked EPSCs in enkephalin-positive medium spiny neurons in DLS slices. Thus, EtOH and nicotine pretreatment may modulate glutamatergic synapses in the DLS presynaptically. Bath application of the CB1 receptor agonist Win 55,2-212 increased the paired-pulse ratio of evoked EPSCs in control slices, while Win 55,2-212 had no effect on paired-pulse ratio in slices from either EtOH- or nicotine-pretreated rats. Consistent with these effects, nicotine pretreatment occluded LTD induction by high-frequency stimulation of the corticostriatal inputs to the dorsolateral striatum. These results suggest that nicotine and EtOH pretreatment modulates striatal synapses to induce tolerance to the motor-impairing effects of EtOH, which may contribute to nicotine and EtOH coabuse. PMID:27517088

  18. [Tolerance and metabolic results of long-term administration of a mixture of saturated triglycerides by recto-colic route in rabbits].

    PubMed

    Dorier, A; Perret, J P; Bacques, C

    1976-01-01

    Rabbit's and Dog's colonic absorption of triglycerides is shown in previous works. Further, we are studying the possibility to use the rectal route for nutritive substances. This way remains now poorly used and an exceptional therapeutic. However, bringing triglycerides in adequate state would be an energetic, supply, all the more as it is very difficult to provide potent caloric source in parenteral nutrition. This is why we investigate, on the Rabbit, the issues of chronic administration of glycerides by rectal route, on caloric balance and on a biochemical view to seek for in lipid composition of tissues the print of lipids administrated by transanal way. The animals are individually housed in metabolism units feeding a standard diet and drinking ad libitum. The treated subjects are given by transanal way, twice a day, for eight weeds, a sum of 1 g/kg of medium chain triglycerides. The metabolic balance-sheet is daily drawn. The clinic balance-sheet is set on the end, by biological controls to explore the hepatic and renal function (prothrombine ratio, transaminases (SGOT, SGPT), ornithine, carbamyl transferase (OCT), urea, total proteins ratio and electrolyte imbalance. We measure also the concentration of total lipids plasma and tissue (liver, kidney, heart, lungs, perirenal adipose tissue). The triglyceride composition and fatty acid composition of different lipids fractions of control and treated subjects are analyzed by gas-liquid chromatography. The animals support perfectly, without damage, a chronic and massive (1 g/kg/each day) administration of medium chain triglycerides by rectal route. The growth of treated subjects is normal. On the opposite, they adjust their alimentary consumption with the caloric charge of the diet, this is the reason why the reduction is about 12p. 100 with respect to the control animals. The coli-rectal administration of saturated glycerides produces at middle end only qualitative variations of lipids extracts. They essentially

  19. Florida Keys

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The Florida Keys are a chain of islands, islets and reefs extending from Virginia Key to the Dry Tortugas for about 309 kilometers (192 miles). The keys are chiefly limestone and coral formations. The larger islands of the group are Key West (with its airport), Key Largo, Sugarloaf Key, and Boca Chica Key. A causeway extends from the mainland to Key West.

    This image was acquired on October 28, 2001, by the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite. With its 14 spectral bands from the visible to the thermal infrared wavelength region, and its high spatial resolution of 15 to 90 meters (about 50 to 300 feet), ASTER images Earth to map and monitor the changing surface of our planet.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER will provide scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

    Dr. Anne Kahle at NASA's Jet Propulsion Laboratory, Pasadena, Calif., is the U.S. Science team leader; Bjorn Eng of JPL is the project manager. The Terra mission is part of NASA's Earth Science Enterprise, a long- term research effort to understand and protect our home planet. Through the study of Earth, NASA will help to provide sound science to policy and economic

  20. Traditional Chinese medicine and sports drug testing: identification of natural steroid administration in doping control urine samples resulting from musk (pod) extracts.

    PubMed

    Thevis, Mario; Schänzer, Wilhelm; Geyer, Hans; Thieme, Detlef; Grosse, Joachim; Rautenberg, Claudia; Flenker, Ulrich; Beuck, Simon; Thomas, Andreas; Holland, Ruben; Dvorak, Jiri

    2013-01-01

    The administration of musk extract, that is, ingredients obtained by extraction of the liquid secreted from the preputial gland or resulting grains of the male musk deer (eg, Moschus moschiferus), has been recommended in Traditional Chinese Medicine (TCM) applications and was listed in the Japanese pharmacopoeia for various indications requiring cardiovascular stimulation, anti-inflammatory medication or androgenic hormone therapy. Numerous steroidal components including cholesterol, 5α-androstane-3,17-dione, 5β-androstane-3,17-dione, androsterone, etiocholanolone, epiandrosterone, 3β-hydroxy-androst-5-en-17-one, androst-4-ene-3,17-dione and the corresponding urea adduct 3α-ureido-androst-4-en-17-one were characterised as natural ingredients of musk over several decades, implicating an issue concerning doping controls if used for the treatment of elite athletes. In the present study, the impact of musk extract administration on sports drug testing results of five females competing in an international sporting event is reported. In the course of routine doping controls, adverse analytical findings concerning the athletes' steroid profile, corroborated by isotope-ratio mass spectrometry (IRMS) data, were obtained. The athletes' medical advisors admitted the prescription of TCM-based musk pod preparations and provided musk pod samples for comparison purposes to clarify the antidoping rule violation. Steroid profiles, IRMS results, literature data and a musk sample obtained from a living musk deer of a local zoo conclusively demonstrated the use of musk pod extracts in all cases which, however, represented a doping offence as prohibited anabolic-androgenic steroids were administered.

  1. Key Nutrients.

    ERIC Educational Resources Information Center

    Federal Extension Service (USDA), Washington, DC.

    Lessons written to help trainer agents prepare aides for work with families in the Food and Nutrition Program are presented in this booklet. The key nutrients discussed in the 10 lessons are protein, carbohydrates, fat, calcium, iron, iodine, and Vitamins A, B, C, and D. the format of each lesson is as follows: Purpose, Presentation, Application…

  2. Validation and ease of use of a new pen device for self-administration of recombinant human growth hormone: results from a two-center usability study.

    PubMed

    Rapaport, Robert; Saenger, Paul; Schmidt, Heinrich; Hasegawa, Yukihiro; Colle, Michel; Loche, Sandro; Marcantonio, Sandra; Bonfig, Walter; Zabransky, Markus; Lifshitz, Fima

    2013-01-01

    Close adherence to the recommended treatment regimen is important for the success of recombinant human growth hormone therapy, although nonadherence can be common. Ease of use and safety during use/storage are among several important factors in the design of a growth hormone injection device intended for long-term use. This study was performed to validate the usability and assess the ease of use of a new pen device (SurePal™) that has been developed to support daily administration of the recombinant human growth hormone product, Omnitrope® (somatropin). The primary objectives of the study were to assess if study participants, representing intended users of the pen in clinical practice, were able to perform an injection procedure into an injection pad effectively and safely and disassemble the pen without receiving a needlestick injury. A total of 106 participants (61 adults and 45 children/adolescents) were enrolled at two study centers (one in the US, one in Germany). Results for both primary usability tasks met the predefined acceptance criteria, with >85% of participants successfully performing each task. All of the other tasks/handling steps assessed were also successfully performed by most participants, with high success rates reflected in the high proportion of participants who classified each task as "very easy" or "easy". After a second use of the device, 87%-97% of participants rated it as "very easy" or "easy" to use. In summary, the new pen device is safe and easy to use for both adults and children, and will help to support effective, long-term daily administration of the recombinant human growth hormone product, Omnitrope®.

  3. Validation and ease of use of a new pen device for self-administration of recombinant human growth hormone: results from a two-center usability study

    PubMed Central

    Rapaport, Robert; Saenger, Paul; Schmidt, Heinrich; Hasegawa, Yukihiro; Colle, Michel; Loche, Sandro; Marcantonio, Sandra; Bonfig, Walter; Zabransky, Markus; Lifshitz, Fima

    2013-01-01

    Close adherence to the recommended treatment regimen is important for the success of recombinant human growth hormone therapy, although nonadherence can be common. Ease of use and safety during use/storage are among several important factors in the design of a growth hormone injection device intended for long-term use. This study was performed to validate the usability and assess the ease of use of a new pen device (SurePal™) that has been developed to support daily administration of the recombinant human growth hormone product, Omnitrope® (somatropin). The primary objectives of the study were to assess if study participants, representing intended users of the pen in clinical practice, were able to perform an injection procedure into an injection pad effectively and safely and disassemble the pen without receiving a needlestick injury. A total of 106 participants (61 adults and 45 children/adolescents) were enrolled at two study centers (one in the US, one in Germany). Results for both primary usability tasks met the predefined acceptance criteria, with >85% of participants successfully performing each task. All of the other tasks/handling steps assessed were also successfully performed by most participants, with high success rates reflected in the high proportion of participants who classified each task as “very easy” or “easy”. After a second use of the device, 87%–97% of participants rated it as “very easy” or “easy” to use. In summary, the new pen device is safe and easy to use for both adults and children, and will help to support effective, long-term daily administration of the recombinant human growth hormone product, Omnitrope®. PMID:24039458

  4. Aerospace, Official Publication of the Aerospace Industries Association of America, Inc., Vol. 15, No. 2, Summer 1977. Goals for America: President Carter and Key Administration Leaders Report on their Goals for America.

    ERIC Educational Resources Information Center

    McAllister, Gerald J., Ed.

    This document reports on the goals of the President's Cabinet Officers. Included are those by the Secretaries of Agriculture; Commerce; Health, Education and Welfare; Labor; Transportation; Treasury; and Defense. Also included are those by the Administrators of the Federal Energy Administration and the National Aeronautics and Space…

  5. Competencies Needed by Chief School Business Administrators. A Report on the Results, Conclusions and Implications of a Research Study to Identify the Competencies Needed by Chief School Business Administrators in Large and Small School Districts.

    ERIC Educational Resources Information Center

    McGuffey, C. W.

    A national survey sought to identify the competencies that chief school business administrators (CSBAs) in large and small school districts think are important for their job. Seventy-five respondents, out of a random stratified sample comprising 143 members of the Association of School Business Officials, ranked 264 statements in 28 major task…

  6. Visualization of the transgene distribution according to the administration route allows prediction of the transfection efficacy and validation of the results obtained.

    PubMed

    Delepine, P; Montier, T; Guillaume, C; Vaysse, L; Le Pape, A; Ferec, C

    2002-06-01

    Gene transfer to the lung can be achieved via a systemic, that targets the endothelium, or local, that targets the epithelium, delivery route. In the present study, we followed the distribution of a plasmid after transfection using some of our phosphonolipids, which have previously shown their efficiency in transfecting mouse lungs. The plasmid was radiolabeled and varying combinations of plasmid/phosphonolipid were administered by intravenous injection, or by endotracheal spray. The distribution of radioactive labeling was observed over a time course using a gamma-camera. These images were then correlated with the results for luciferase expression levels in the lungs. In each case, lungs were well targeted. However, whereas an intravenous injection reaches all of the lung immediately, progressive diffusion occurs when the plasmid/phosphonolipid is administered via an aerosol. Elimination of the radioactivity associated with plasmid occurs via the urinary tract after intravenous injections, and via the feces using the aerosol delivery approach. The radioactivity detected in the lungs correlated strongly with transgene expression. Thus, such an imaging technique is a powerful strategy to predict the formulation that will generate the best transfection efficiency. This study reveals that scintigraphic imaging permits both validation of the administration method and the results obtained for each animal, thereby reducing the statistical variability of in vivo experiments.

  7. Preliminary Results of a Phase I Trial of Prophylactic Ethanol-Lock Administration to Prevent Mediport Catheter-Related Bloodstream Infections

    PubMed Central

    Kayton, Mark L.; Garmey, Edward G.; Ishill, Nicole M.; Cheung, Nai-Kong V.; Kushner, Brian H.; Kramer, Kim; Modak, Shakeel; Rossetto, Carol; Hennelly, Courtney; Doyle, Melissa Parra; Rosenberg, Shoshana; Santoro, Olga; La Quaglia, Michael P.

    2015-01-01

    Background Catheter-related bloodstream infections remain costly with no simple prevention. We report preliminary results of a phase I trial of ethanol-lock administration to prevent mediport catheter-related bloodstream infections in children. Methods Twelve patients receiving intravenous antibody treatments for neuroblastoma were enrolled. On 4 days of each 5-day antibody cycle, 70% ethanol was administered instead of heparin to dwell in each patient’s mediport overnight. We used clinical monitoring/questionnaires to assess symptoms; and measured blood ethanol levels and liver functions. Patients were tracked for positive blood cultures. Time-to-infection for ethanol-lock treated patients was compared with historical controls. Results We administered 123 ethanol-locks. No adverse symptoms attributable to ethanol occurred; one patient’s urticaria worsened. Blood ethanol levels averaged 11 mg/dL. The study was voluntarily suspended after 3 patients’ catheters became occluded, 1 of which fractured. A positive blood culture occurred in 1 of 12 patients (8%), but suspension of the study precluded statistical power to detect impact on time-to-infection. Conclusions Although children with mediport catheters exhibited nontoxic blood ethanol levels and a low rate of bloodstream infections following prophylactic ethanol-lock use, there was a high incidence of catheter occlusion. Adjustments are necessary before adopting ethanol-locks for routine prophylaxis against catheter infections in children. PMID:20920713

  8. Do Prescription Drug Ads Tell Consumers Enough About Benefits and Side Effects? Results From the Health Information National Trends Survey, Fourth Administration.

    PubMed

    Sullivan, Helen W; Campbell, Miriam

    2015-01-01

    Direct-to-consumer prescription drug advertising (DTCA) is a major source of consumer information about prescription drugs. The present study updates 2002 U.S. Food and Drug Administration phone survey questions that found that 44% and 61% of consumers thought that DTCA did not include enough information about benefits and risks, respectively. The present study was administered by mail using a nationally representative sample, and provides a more in-depth understanding of how these beliefs relate to demographic and health characteristics. Data collected from 3,959 respondents to the National Cancer Institute's 2011 Health Information National Trends Survey find results similar to the 2002 survey: 46% and 52% of respondents thought that DCTA did not include enough information about benefits and risks, respectively. Respondents fell into four groups: 23% agreed that DTCA tells enough about drug benefits and risks, 41% disagreed, 18% expressed no opinion, and 18% had discordant beliefs. DTCA attitudes were negatively associated with education, income, and whether respondents purchase prescription drugs; attitudes were positively associated with whether respondents understand prescription drug information. This study confirms that a plurality of Americans believe that DTCA does not include enough information about benefits and risks, suggesting that the educational effect of DTCA could be improved.

  9. Practical and Secure Recovery of Disk Encryption Key Using Smart Cards

    NASA Astrophysics Data System (ADS)

    Omote, Kazumasa; Kato, Kazuhiko

    In key-recovery methods using smart cards, a user can recover the disk encryption key in cooperation with the system administrator, even if the user has lost the smart card including the disk encryption key. However, the disk encryption key is known to the system administrator in advance in most key-recovery methods. Hence user's disk data may be read by the system administrator. Furthermore, if the disk encryption key is not known to the system administrator in advance, it is difficult to achieve a key authentication. In this paper, we propose a scheme which enables to recover the disk encryption key when the user's smart card is lost. In our scheme, the disk encryption key is not preserved anywhere and then the system administrator cannot know the key before key-recovery phase. Only someone who has a user's smart card and knows the user's password can decrypt that user's disk data. Furthermore, we measured the processing time required for user authentication in an experimental environment using a virtual machine monitor. As a result, we found that this processing time is short enough to be practical.

  10. Rapid subcutaneous immunoglobulin administration every second week results in high and stable serum immunoglobulin G levels in patients with primary antibody deficiencies

    PubMed Central

    Gustafson, R; Gardulf, A; Hansen, S; Leibl, H; Engl, W; Lindén, M; Müller, A; Hammarström, L

    2008-01-01

    Subcutaneous immunoglobulin G (SCIG) infusions as life-long replacement therapy in patients with primary antibody deficiences (PAD) is being applied increasingly. However, only a few published pharmacokinetic studies are available for this route of administration. Therefore, the pharmacokinetics of a 16% immunoglobulin G (IgG) preparation intended for subcutaneous use were investigated in patients with common variable immunodeficiency and X-linked agammaglobulinaemia. SCIG infusions (200 mg/kg body weight) were administered to 12 adult patients every 14 days for 24 weeks (total of 144 infusions). Pharmacokinetic parameters were determined based on serum IgG trough levels and antibody levels against tetanus. The median half-life of the total serum IgG and for the tetanus antibodies was 40·6 and 23·3 days respectively. Median in vivo recovery of serum IgG and tetanus immunoglobulins were 36% and 46% respectively. Median, preinfusion serum IgG trough levels per patient were high without major variations between infusions and ranged from 7·24 to 7·86 g/l. Safety, in terms of adverse events including systemic adverse reactions and local tissue reactions at infusions sites, was monitored throughout the study. Six mild, local tissue reactions were observed during the study in one patient. No systemic adverse reactions related to the study drug were observed and no serious other adverse event occurred during the study. It is concluded that the bi-weekly SCIG therapy was well tolerated in the study and that it results in high and stable serum IgG levels, offering an alternative therapy regimen to patients suffering from PAD. PMID:18341618

  11. Concurrent administration of adjuvant chemotherapy and radiotherapy after breast-conserving surgery enhances late toxicities: Long-term results of the ARCOSEIN multicenter randomized study

    SciTech Connect

    Toledano, Alain . E-mail: alain.toledano@gmail.com; Garaud, Pascal; Serin, Daniel; Fourquet, Alain; Bosset, Jean-Francois; Breteau, Noel; Body, Gilles; Azria, David; Le Floch, Olivier; Calais, Gilles

    2006-06-01

    Purpose: In 1996, a multicenter randomized study was initiated that compared sequential vs. concurrent adjuvant chemotherapy (CT) with radiation therapy (RT) after breast-conserving surgery (ARCOSEIN study). After a median follow-up of 6.7 years (range, 4.3-9 years), we decided to prospectively evaluate the late effects of these 2 strategies. Methods and Materials: A total of 297 patients from the 5 larger participating institutions were asked to report for a follow-up examination. Seventy-two percent (214 patients) were eligible for evaluation of late toxicity. After breast-conserving surgery, patients were treated either with sequential treatment with CT first followed by RT (Arm A) or CT administered concurrently with RT (Arm B). In all patients, CT regimen consisted of mitoxantrone (12 mg/m{sup 2}), 5-FU (500 mg/m{sup 2}), and cyclophosphamide (500 mg/m{sup 2}), 6 cycles (Day 1 to Day 21). Conventional RT was delivered to the whole breast by administration of a 2 Gy per fraction protocol to a total dose of 50 Gy ({+-} boost to the primary tumor bed). The assessment of toxicity was blinded to treatment and was graded by the radiation oncologist, according to the LENT/SOMA scale. Skin pigmentation was also evaluated according to a personal 5-points scoring system (excellent, good, moderate, poor, very poor). Results: Among the 214 evaluable patients, 107 were treated in each arm. The 2 populations were homogeneous for patient, tumor, and treatment characteristics. Subcutaneous fibrosis (SF), telangectasia (T), skin pigmentation (SP), and breast atrophy (BA) were significantly increased in Arm B. No statistical difference was observed between the 2 arms of the study concerning Grade 2 or higher pain, breast edema, or lymphedema. No deaths were caused by late toxicity. Conclusion: After breast-conserving surgery, the concurrent use of CT with RT is significantly associated with an increase incidence of Grade 2 or greater late side effects.

  12. Can We Stop Mass Drug Administration for Trachoma Prior to 3 Annual Rounds in Hypoendemic Communities? Results from PRET Ziada Trial in Tanzania

    PubMed Central

    Yohannan, Jithin; Munoz, Beatriz; Mkocha, Harran; Gaydos, Charlotte; Bailey, Robin; Lietman, Thomas; Quinn, Thomas; West, Sheila K

    2013-01-01

    Background The World Health Organization recommends at least 3 annual mass drug administration (MDA)rounds of Azithromycin at 80% coverage to eliminate trachoma in communities where prevalence is greater than 10% in children aged 1 to 9 years. However, stopping MDA prior to 3 rounds, if monitoring indicates absence of infection with C. trachomatis, may be more cost effective in low prevalence settings. Trial design 1:1 community randomized, double blinded trial Trial Methods 16 communities with estimated trachoma prevalence between 10–20% were randomized into one of two treatment groups: Usual care of 3 rounds of MDA; Cessation Rule group where if the estimated prevalence of infection fell below 5% after one or two rounds of MDA, that community would cease to receive any further MDA. The primary outcome was the prevalence of C. Trachomatis infection in children ages under five years at 36 months. Results There was no significant difference in baseline characteristics or prevalence of infection or trachoma between the two randomization arms. None of the communities assigned to the cessation arm ever met criteria to stop MDA, so all 16 communities received 2 rounds of MDA and were scheduled to go on for a third round. For this reason, the trial was stopped after the 18 month survey. At 18 months there was no difference in infection prevalence (2.9% versus 4.7%, p=0.25) or trachoma prevalence (6.5% versus 9.4%, p=0.14) between the usual care group and cessation group respectively. Conclusion In this trial, communities with low (10–20%) initial prevalence of trachoma could not stop MDA before 3 annual rounds with 80% coverage. PMID:23392481

  13. Administrative Synergy

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  14. Strength of object representation: its key role in object-based attention for determining the competition result between Gestalt and top-down objects.

    PubMed

    Zhao, Jingjing; Wang, Yonghui; Liu, Donglai; Zhao, Liang; Liu, Peng

    2015-10-01

    It was found in previous studies that two types of objects (rectangles formed according to the Gestalt principle and Chinese words formed in a top-down fashion) can both induce an object-based effect. The aim of the present study was to investigate how the strength of an object representation affects the result of the competition between these two types of objects based on research carried out by Liu, Wang and Zhou [(2011) Acta Psychologica, 138(3), 397-404]. In Experiment 1, the rectangles were filled with two different colors to increase the strength of Gestalt object representation, and we found that the object effect changed significantly for the different stimulus types. Experiment 2 used Chinese words with various familiarities to manipulate the strength of the top-down object representation. As a result, the object-based effect induced by rectangles was observed only when the Chinese word familiarity was low. These results suggest that the strength of object representation determines the result of competition between different types of objects.

  15. Improving Instruction for Students with Learning Disabilities: The Results of Three Research Syntheses. Keys to Successful Learning: A National Summit on Research in Learning Disabilities.

    ERIC Educational Resources Information Center

    National Center for Learning Disabilities, Inc., New York, NY.

    This booklet presents three brief papers that summarize three meta-analytic research syntheses of instruction for students with learning disabilities. The first paper is "Intervention Research for Students with Learning Disabilities" by H. Lee Swanson. Findings that resulted from a review of 272 studies are grouped into those on most effective…

  16. New species of Diabrotica Chevrolat (Coleoptera: Chrysomelidae: Galerucinae) and a key to Diabrotica and related genera: results of a synopsis of North and Central American Diabrotica species

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The following 18 new species of Diabrotica are described and illustrated as a result of the synopsis of North and Centrla American species: D. barclayi nov. sp. Guatemala, D. caveyi nov. sp. Costa Rica, D. costaricensis nov. sp. Costa Rica, D. dmitryogloblini nov. sp. Mexico, D. duckworthae nov. sp....

  17. Collaborative Behaviors Practiced by Teachers and Their Administrators Resulting in Increased California High School Exit Exam Pass Rates for Students with Learning Disabilities

    ERIC Educational Resources Information Center

    Everett, Katherine E.

    2013-01-01

    Purpose. The purpose of this replication study was to describe the extent to which seven collaborative behaviors were demonstrated by general education teachers assigned students with disabilities, education specialists, and their administrators in selected California high schools that exceeded the state average pass rate for 10th-grade students…

  18. Alkaline Leaching of Key, Non-Radioactive Components from Simulants and Hanford Tank Sludge 241-S-110: Results of FY01 Studies

    SciTech Connect

    Rapko, Brian M.; Vienna, John D.; Sinkov, Serguei I.; Kim, Jinseong; Cisar, Alan J.

    2002-09-10

    This study addressed three aspects in selected alkaline leaching: first, the use of oxidants persulfate, permanganate, and ferrate as selective chromium-leaching agents from washed Hanford Tank S-110 solids under varying conditions of hydroxide concentration, temperature, and time was investigated. Second, the selective dissolution of solids containing mercury(II) oxide under alkaline conditions was examined. Various compounds were studied for their effectiveness in dissolving mercury under varying conditions of time, temperature, and hydroxide concentration in the leachate. Three compounds were studied: cysteine, iodide, and diethyldithiophosphoric acid (DEDTPA). Finally, the possibility of whether an oxidant bound to an anion-exchange resin can be used to effectively oxidize chromium(III) in alkaline solutions was addressed. The experimental results remain ambiguous to date; further work is required to reach any definitive conclusions as to the effectiveness of this approach.

  19. Mortality as a key driver of the spatial distribution of aboveground biomass in Amazonian forests: results from a Dynamic Vegetation Model

    NASA Astrophysics Data System (ADS)

    Delbart, N.; Ciais, P.; Chave, J.; Viovy, N.; Malhi, Y.; Le Toan, T.

    2010-04-01

    Dynamic Vegetation Models (DVMs) simulate energy, water and carbon fluxes between the ecosystem and the atmosphere, between the vegetation and the soil, and between plant organs. They also estimate the potential biomass of a forest in equilibrium having grown under a given climate and atmospheric CO2 level. In this study, we evaluate the above ground woody biomass (AGWB) and the above ground woody Net Primary Productivity (NPPAGW) simulated by the DVM ORCHIDEE across Amazonian forests, by comparing the simulation results to a large set of ground measurements (220 sites for biomass, 104 sites for NPPAGW). We found that the NPPAGW is on average overestimated by 63%. We also found that the fraction of biomass that is lost through mortality is 85% too high. These model biases nearly compensate each other to give an average simulated AGWB close to the ground measurement average. Nevertheless, the simulated AGWB spatial distribution differs significantly from the observations. Then, we analyse the discrepancies in biomass with regards to discrepancies in NPPAGW and those in the rate of mortality. When we correct for the error in NPPAGW, the errors on the spatial variations in AGWB are exacerbated, showing clearly that a large part of the misrepresentation of biomass comes from a wrong modelling of mortality processes. Previous studies showed that Amazonian forests with high productivity have a higher mortality rate than forests with lower productivity. We introduce this relationship, which results in strongly improved modelling of biomass and of its spatial variations. We discuss the possibility of modifying the mortality modelling in ORCHIDEE, and the opportunity to improve forest productivity modelling through the integration of biomass measurements, in particular from remote sensing.

  20. Mortality as a key driver of the spatial distribution of aboveground biomass in Amazonian forest: results from a dynamic vegetation model

    NASA Astrophysics Data System (ADS)

    Delbart, N.; Ciais, P.; Chave, J.; Viovy, N.; Malhi, Y.; Le Toan, T.

    2010-10-01

    Dynamic Vegetation Models (DVMs) simulate energy, water and carbon fluxes between the ecosystem and the atmosphere, between the vegetation and the soil, and between plant organs. They also estimate the potential biomass of a forest in equilibrium having grown under a given climate and atmospheric CO2 level. In this study, we evaluate the Above Ground Woody Biomass (AGWB) and the above ground woody Net Primary Productivity (NPPAGW) simulated by the DVM ORCHIDEE across Amazonian forests, by comparing the simulation results to a large set of ground measurements (220 sites for biomass, 104 sites for NPPAGW). We found that the NPPAGW is on average overestimated by 63%. We also found that the fraction of biomass that is lost through mortality is 85% too high. These model biases nearly compensate each other to give an average simulated AGWB close to the ground measurement average. Nevertheless, the simulated AGWB spatial distribution differs significantly from the observations. Then, we analyse the discrepancies in biomass with regards to discrepancies in NPPAGW and those in the rate of mortality. When we correct for the error in NPPAGW, the errors on the spatial variations in AGWB are exacerbated, showing clearly that a large part of the misrepresentation of biomass comes from a wrong modelling of mortality processes. Previous studies showed that Amazonian forests with high productivity have a higher mortality rate than forests with lower productivity. We introduce this relationship, which results in strongly improved modelling of biomass and of its spatial variations. We discuss the possibility of modifying the mortality modelling in ORCHIDEE, and the opportunity to improve forest productivity modelling through the integration of biomass measurements, in particular from remote sensing.

  1. The Effect of Intrathecal Administration of Muscimol on Modulation of Neuropathic Pain Symptoms Resulting from Spinal Cord Injury; an Experimental Study

    PubMed Central

    Hosseini, Marjan; Karami, Zohreh; Janzadenh, Atousa; Jameie, Seyed Behnamedin; Haji Mashhadi, Zahra; Yousefifard, Mahmoud; Nasirinezhad, Farinaz

    2014-01-01

    Introduction: Neuropathic pain can be very difficult to treat and it is one of the important medical challenging about pain treatments. Muscimol as a new agonist of gamma-Aminobutyric acid receptor type A (GABAA) have been introduced for pain management. Thus, the present study was performed to evaluate the pain alleviating effect of intrathecal injection of different doses of muscimol as GABAA receptor agonist in spinal cord injury (SCI) model of neuropathic pain. Methods: In the present experimental study, male Wistar rats were treated by muscimol 0.01, 0.1 or 1 µg/10ul, intrathecally (i.t.) three weeks after induction of spinal cord injury using compression injury model. Neuropathic pain symptoms were assessed at before treatment, 15 minutes, one hour and three hours after muscimol administration. The time of peak effect and optimum dosage was assessed by repeated measures analysis of variance and analysis of covariance, respectively. Results: Muscimol with the dose of 0.01 µg in 15 minutes caused to improve the thermal hyperalgesia (df: 24, 5; F= 6.6; p<0.001), mechanical hyperalgesia (df: 24, 5; F= 7.8; p<0.001), cold allodynia (df: 24, 5; F= 6.96; p<0.001), and mechanical allodynia (df: 24, 5; F= 15.7; p<0.001). The effect of doses of 0.1 µg and 1 µg were also significant. In addition, the efficacy of different doses of muscimol did not have difference on thermal hyperalgesia (df: 24, 5; F= 1.52; p= 0.24), mechanical hyperalgesia (df: 24, 5; F= 0.3; p= -0.75), cold allodynia (df: 24, 5; F= 0.8; p= -0.56), and mechanical allodynia (df: 24, 5; F= 1.75; p= 0.86). Conclusion: The finding of the present study revealed that using muscimol with doses of 0.01µg, 0.1µg, and 1 µg reduces the symptoms of neuropathic pain. In addition, the effect of GABAA agonist is short term and its effectiveness gradually decreases by time. PMID:26495371

  2. Overview of JT-60U results towards the resolution of key physics and engineering issues in ITER and JT-60SA

    NASA Astrophysics Data System (ADS)

    Isayama, A.; JT-60 Team

    2011-09-01

    This paper presents an overview of recent results from JT-60U. Topics we particularly focus on are (1) the mechanism determining the rotation profile and the effect of rotation on/from transport and stability, (2) the edge localized mode (ELM) physics and active ELM control and (3) plasma-wall interactions. An analysis of the momentum transport showed that rotation with a high pressure gradient can be reproduced by introducing a residual stress term proportional to the momentum diffusivity and the pressure gradient. Also, the momentum diffusivity in an internal transport barrier (ITB) region was reduced to an order similar to that of the ion thermal diffusivity. A comparison of the edge pedestal characteristics between JT-60U and JET with matched shape and operational parameters showed that the edge pressure did not change with increasing toroidal field (TF) ripple up to 1%, whereas a linear shift of the rotation velocity to the counter-direction was observed with increasing TF ripple. The absolute evaluation of tungsten accumulation in the core plasma by a spectroscopic method clarified that tungsten accumulation increased with increasing toroidal rotation in the counter-direction while an H-mode was sustained even at a tungsten density of 10-3 times the electron density. Active control of neoclassical tearing mode (NTM) islands by the electron cyclotron current drive showed that the growth of NTM islands decelerated the plasma rotation. A transition to a low-rotation frequency state occurred for larger NTM islands. A statistical analysis of the precursor of type I ELM showed a small growth rate of γ/ωA ~ 10-3 (where γ and ωA are the growth rate and Alfvén angular frequency, respectively). The measurement of the precursor at different toroidal locations showed that the toroidal mode number was 8-10 or 14-16. Energetic-particle-driven wall modes (EWMs) were found to trigger ELMs and decrease the ELM amplitude to half of that without EWMs. Enhancement of the

  3. Key Results of Interaction Models with Centering

    ERIC Educational Resources Information Center

    Afshartous, David; Preston, Richard A.

    2011-01-01

    We consider the effect on estimation of simultaneous variable centering and interaction effects in linear regression. We technically define, review, and amplify many of the statistical issues for interaction models with centering in order to create a useful and compact reference for teachers, students, and applied researchers. In addition, we…

  4. The Supernova Key Project

    NASA Astrophysics Data System (ADS)

    Howell, Dale Andrew

    2017-01-01

    Las Cumbres Observatory is a global network of robotic telescopes specializing in time domain astronomy. It currently has nine 1m telescopes, two 2m telescopes, and seven 0.4m telescopes. The Supernova Key Project is a 3 year program to obtain light curves and spectra of 500 supernovae with Las Cumbres Observatory. Here we show recent results, detail plans for the next Supernova Key Project, and explain how the US community can get involved.

  5. Administrative Ecology

    ERIC Educational Resources Information Center

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  6. L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion.

    PubMed

    Zukhurova, Mavdzhuda; Prosvirnina, Maria; Daineko, Anastasia; Simanenkova, Anna; Petrishchev, Nikolay; Sonin, Dmitry; Galagudza, Michael; Shamtsyan, Mark; Juneja, Lekh R; Vlasov, Timur

    2013-09-01

    While the neuroprotective effect of green tea (Camellia sinensis) might be explained by the presence of amino acid L-theanine in the tea leaves, it is not known whether postischemic administration of L-theanine could also provide neuroprotection. In the present study, we investigated the neuroprotective effect of L-theanine (1 and 4 mg/kg) administered at 3, 12, and 24 h after reperfusion in the rat model of stroke. We also studied the effect of L-theanine on brain injury caused by exogenous administration of N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-isoxazole-4-propionate/kainate receptor agonists during reperfusion. Rats were subjected to 30-min middle cerebral artery occlusion followed by 48-h reperfusion. Neurological deficit and infarct size were determined at the end of reperfusion. At 3 and 12 h, but not at 24 h of reperfusion, L-theanine substantially reduced the size of brain infarct. Neurological status was improved when L-theanine was administered 3, 12, and 24 h after reperfusion. Repeated intrastriatal injections of L-theanine at a total dose of 800 µg/kg during reperfusion prevented brain injury caused by glutamate receptor agonists. In conclusion, L-theanine at reperfusion exerts neuroprotective effect in the in vivo rat model of stroke. Local treatment with L-theanine at reperfusion prevents glutamate receptor agonist-mediated brain injury.

  7. Key Skills Influencing Student Achievement

    ERIC Educational Resources Information Center

    Balch, Tonya; Gruenert, Steve

    2009-01-01

    A predictive, non-experimental, cross-sectional design (Johnson, 2001) was used to conduct a study to determine if elementary administrators' key counseling skills and select demographics predicted state-level student performance indicators in their respective schools. A secondary purpose of this study was to develop a valid and reliable on-line…

  8. Pharmacokinetics of lamivudine and lamivudine-triphosphate after administration of 300 milligrams and 150 milligrams once daily to healthy volunteers: results of the ENCORE 2 study.

    PubMed

    Else, Laura J; Jackson, Akil; Puls, Rebekah; Hill, Andrew; Fahey, Paul; Lin, Enmoore; Amara, Alieu; Siccardi, Marco; Watson, Victoria; Tjia, John; Emery, Sean; Khoo, Saye; Back, David J; Boffito, Marta

    2012-03-01

    There is interest in evaluating the efficacy of lower doses of certain antiretrovirals for clinical care. We determined here the bioequivalence of plasma lamivudine (3TC) and intracellular 3TC-triphosphate (3TC-TP) concentrations after the administration of two different doses. ENCORE 2 was a randomized crossover study. Subjects received 3TC at 300 and 150 mg once daily for 10 days (arm 1; n = 13) or vice versa (arm 2; n = 11), separated by a 10-day washout. Pharmacokinetic (PK) profiles (0 to 24 h) were assessed on days 10 and 30. Plasma 3TC and 3TC-TP levels in peripheral blood mononuclear cells were quantified by high-performance liquid chromatography-tandem mass spectrometry. Within-subject changes in PK parameters (the area under the concentration-time curve from 0 to 24 h [AUC(0-24)], the trough concentration of drug in plasma at 24 h [C(24)], and the maximum concentration of drug in plasma [C(max)]) were evaluated by determining the geometric mean ratios (GMRs) adjusted for study arm, period, and intra-individual variation. Regimens were considered bioequivalent if the 90% confidence interval (90% CI) fell within the range of 0.8 to 1.25. A total of 24 subjects completed the study. The GM (90% CI) 3TC AUC(0-24)), expressed as ng·h/ml, for the 300- and 150-mg doses were 8,354 (7,609 to 9,172) and 4,773 (4,408 to 5,169), respectively. Bioequivalence in 3TC PK following the administration of 300 and 150 mg was not demonstrated: the GMRs for AUC(0-24), C(24), and C(max) were 0.57 (0.55 to 0.60), 0.63 (0.59 to 0.67), and 0.56 (0.53 to 0.60), respectively. The GM (90% CI) 3TC-TP AUC(0-24) values (pmol·h/10(6) cells) for the 300- and 150-mg doses were 59.5 (51.8 to 68.3) and 44.0 (38.0 to 51.0), respectively. Bioequivalence in 3TC-TP PK following the administration of 300 and 150 mg was not demonstrated: the GMRs for AUC(0-24), C(24), and C(max) were 0.73 (0.64 to 0.83), 0.82 (0.68 to 0.99), and 0.70 (0.61 to 0.82), respectively. We found that 3TC at 150 mg is

  9. Oral administration of Lactococcus lactis subsp. lactis JCM5805 enhances lung immune response resulting in protection from murine parainfluenza virus infection.

    PubMed

    Jounai, Kenta; Sugimura, Tetsu; Ohshio, Konomi; Fujiwara, Daisuke

    2015-01-01

    When activated by viral infection, plasmacytoid dendritic cells (pDCs) play a primary role in the immune response through secretion of IFN-α. Lactococcus lactis subsp. lactis JCM5805 (JCM5805) is a strain of lactic acid bacteria (LAB) that activates murine and human pDCs to express type I and type III interferons (IFNs). JCM5805 has also been shown to activate pDCs via a Toll-like receptor 9 (TLR9) dependent pathway. In this study, we investigated the anti-viral effects of oral administration of JCM5805 using a mouse model of murine parainfluenza virus (mPIV1) infection. JCM5805-fed mice showed a drastic improvement in survival rate, prevention of weight loss, and reduction in lung histopathology scores compared to control mice. We further examined the mechanism of anti-viral effects elicited by JCM5805 administration using naive mice. Microscopic observations showed that JCM5805 was incorporated into CD11c+ immune cells in Peyer's patches (PP) and PP pDCs were significantly activated and the expression levels of IFNs were significantly increased. Interestingly, nevertheless resident pDCs at lung were not activated and expressions levels of IFNs at whole lung tissue were not influenced, the expressions of anti-viral factors induced by IFNs, such as Isg15, Oasl2, and Viperin, at lung were up-regulated in JCM5805-fed mice compared to control mice. Therefore expressed IFNs from intestine might be delivered to lung and IFN stimulated genes might be induced. Furthermore, elevated expressions of type I IFNs from lung lymphocytes were observed in response to mPIV1 ex vivo stimulation in JCM5805-fed mice compared to control. This might be due to increased ratio of pDCs located in lung were significantly increased in JCM5805 group. Taken together, a specific LAB strain might be able to affect anti-viral immunological profile in lung via activation of intestinal pDC leading to enhanced anti-viral phenotype in vivo.

  10. Administration of a long-acting antiparasitic to pre-pubertal ewe-lambs in Greece results in earlier reproductive activity and improved reproductive performance.

    PubMed

    Mavrogianni, V S; Papadopoulos, E; Fragkou, I A; Gougoulis, D A; Valasi, I; Orfanou, D C; Ptochos, S; Gallidis, E; Fthenakis, G C

    2011-04-19

    We studied the reproductive effects of administration of a long-acting antiparasitic (moxidectin) given to pre-pubertal ewe-lambs in Greece at the beginning of the reproductive season. 45 animals, naturally infected with trichostrongylids, were allocated into treated (n=30, treatment on D0, 21 June) or control (n=15) group. Rams of confirmed fertility, were introduced from 15 August (D55) to 20 December (D182) into the ewe-lambs. Throughout the study (performed at latitude N 36°26', in a flock free from brucellosis, Chlamydophila infection and toxoplasmosis), epg counts were monitored and reproductive performance of ewes was assessed. Up to D112, arithmetic mean epg counts in treated animals were 0; thereafter and up to D350, they were 23-473. Respective figures for controls were 190-977 epg. Reproductive performance parameters for treated and control animals respectively, were as follows; median 'Interval to first mating after ram introduction': 36.5 d and 71.0 (P=0.04); median 'Age at first mating': 8.5m and 10.0m (P=0.045); 'Cycling rate': 20.0% and 6.7% (P=0.03); 'Mating rate': 86.7% and 66.7%; 'Return-to-oestrus rate': 26.7% and 26.7%; 'Abortion rate': 3.3% and 0%; 'Lambing rate': 83.3% and 66.7%; 'Total lambs born per ewe' and 'Liveborn lambs born per ewe': 1.5 and 1.1 (P=0.01); 'Stillbirth rate' 0% and 0% and 'Lamb bodyweight per ewe': 5.0 kg and 3.8 kg (P=0.005). Anthelmintic treatment of pre-pubertal ewes, in order to maximise reproductive performance may be employed as a management strategy according to targets set in individual flocks.

  11. Administrative competencies for physician organizations with capitation.

    PubMed

    Penner, M

    1999-01-01

    In California, it is common for HMOs to capitate physician organizations (e.g., independent practice organizations and multispecialty medical groups) for all professional and outpatient ancillary services (and to share risk for inpatient care) under professional risk capitation contracts. This arrangement exports most of the financial risk from the HMO to the physician organization. When HMOs and physician organizations contract under these arrangements, HMOs delegate many of their administrative functions to physician organizations--giving the physician organization authority to make the decisions needed to manage capitated risk. As a result, administrators of physician organizations must be competent in such areas as provider network development, financial forecasting, utilization and quality management, contract negotiation, and establishing systems for claims, reporting, authorizations, and the like. In this study four HMO and 22 physician organization administrators were interviewed concerning key administrative competencies for managing capitation contracts. The competencies were assessed as key administrative work activities that required specific knowledge, skill, or ability to perform. Identifying these competencies is important for physician organizations preparing for capitated risk and will be essential for organizations preparing for HMO or Medicare capitation.

  12. Rural Administrative Leadership Handbook.

    ERIC Educational Resources Information Center

    Tift, Carolyn

    This resource book on rural administrative leadership is the result of 1988 interviews with school administrators involved in successful rural educational programs. The material is divided into eight chapters, each self-contained for separate use. Chapter 1, "Getting to Know the Community," addresses qualities of living and working in…

  13. Mediated semiquantum key distribution

    NASA Astrophysics Data System (ADS)

    Krawec, Walter O.

    2015-03-01

    In this work, we design a quantum key distribution protocol, allowing two limited semiquantum or "classical" users to establish a shared secret key with the help of a fully quantum server. A semiquantum user can prepare and measure qubits only in the computational basis and so must rely on this quantum server to produce qubits in alternative bases and also to perform alternative measurements. However, we assume that the server is untrusted and we prove the unconditional security of our protocol even in the worst case: when this quantum server is an all-powerful adversary. We also compute a lower bound of the key rate of our protocol, in the asymptotic scenario, as a function of the observed error rate in the channel, allowing us to compute the maximally tolerated error of our protocol. Our results show that a semiquantum protocol may hold similar security to a fully quantum one.

  14. Engineering Administration.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    This book is intended to acquaint naval engineering officers with their duties in the engineering department. Standard shipboard organizations are analyzed in connection with personnel assignments, division operations, and watch systems. Detailed descriptions are included for the administration of directives, ship's bills, damage control, training…

  15. Administrative IT

    ERIC Educational Resources Information Center

    Grayson, Katherine, Ed.

    2006-01-01

    When it comes to Administrative IT solutions and processes, best practices range across the spectrum. Enterprise resource planning (ERP), student information systems (SIS), and tech support are prominent and continuing areas of focus. But widespread change can also be accomplished via the implementation of campuswide document imaging and sharing,…

  16. Database Administrator

    ERIC Educational Resources Information Center

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  17. Results of the Administration of the Computerized Grammar, Spelling, and Punctuation Test to the College of Communication Summer 1992 MICOM Group.

    ERIC Educational Resources Information Center

    Smith, Nancy J.; And Others

    Results of administering a computerized adaptive version of the Grammar, Spelling, and Punctuation Test (GSP) to students in the College of Communication at the University of Texas, Austin were studied. The computerized adaptive version (CAT) was administered for the first time in June 1992 to 35 prospective students who participated in the…

  18. [Administration of MICRONIZED PALMITOYLETHANOLAMIDE (PEA)-transpolydatin in the treatment of chronic pelvic pain in women affected by endometriosis: preliminary results.

    PubMed

    Lo Monte, G; Soave, I; Marci, R

    2013-03-13

    Aim: Aim of the study was to evaluate the effectiveness of micronized palmitoylethanolamide (PEA)-transpolydatin in the treatment of chronic pelvic pain in women affected by endometriosis. Methods: Twenty-four patients with suspected endometriosis affected by severe pelvic pain were enrolled. All patients received two tablets a day of PEA 400 mg and 40 mg polydatin for 90 days consecutively. A Visual Analogic Scale was used for the assessment of the severity of global pain, dysmenorrhea, dyspareunia, dysuria and dischezia. A second questionnaire was submitted to patients to assess the quality of life. The compilation of a diary lead us to evaluate the monthly assumption of any painkillers. Patients were evaluated at the begin of the treatment and then monthly until the end of the study (90 days). The statistical analysis was performed by using the ANOVA for the analysis of variance. Results: Statistically significant results were found in relation to pelvic pain, dysmenorrhea and dyspareunia compared to the initial evaluation of patients. Results related to dysuria and dischezia were not statistically significant (P>0.05). The decrease in pelvic pain leads to an improvement of the quality of life of patients. A decreased assumption of nonsteroidal anti-inflammatory drugs (NSAIDs) was also observed. Conclusion: PEA could be considered an effective supplement to conventional analgesic therapies in the management of pelvic pain related to endometriosis.

  19. Cryptographic Key Management System

    SciTech Connect

    No, author

    2014-02-21

    This report summarizes the outcome of U.S. Department of Energy (DOE) contract DE-OE0000543, requesting the design of a Cryptographic Key Management System (CKMS) for the secure management of cryptographic keys for the energy sector infrastructure. Prime contractor Sypris Electronics, in collaboration with Oak Ridge National Laboratories (ORNL), Electric Power Research Institute (EPRI), Valicore Technologies, and Purdue University's Center for Education and Research in Information Assurance and Security (CERIAS) and Smart Meter Integration Laboratory (SMIL), has designed, developed and evaluated the CKMS solution. We provide an overview of the project in Section 3, review the core contributions of all contractors in Section 4, and discuss bene ts to the DOE in Section 5. In Section 6 we describe the technical construction of the CKMS solution, and review its key contributions in Section 6.9. Section 7 describes the evaluation and demonstration of the CKMS solution in different environments. We summarize the key project objectives in Section 8, list publications resulting from the project in Section 9, and conclude with a discussion on commercialization in Section 10 and future work in Section 11.

  20. Identification of needs and requirements defined by services subordinated to the Minister of the Interior and Administration in key technology and user interfaces to develop a concept of the Video Signals Integrator (VSI) system

    NASA Astrophysics Data System (ADS)

    Bukowiecka, Danuta; Tyburska, Agata; Struniawski, Jarosław; Jastrzebski, Pawel; Jewartowski, Blazej; Pozniak, Krzysztof; Kasprowicz, Grzegorz; Pastuszak, Grzegorz; Trochimiuk, Maciej; Abramowski, Andrzej; Gaska, Michal; Frasunek, Przemysław; Nalbach-Moszynska, Małgorzata; Brawata, Sebastian; Bubak, Iwona; Gloza, Małgorzata

    2016-09-01

    Preventing and eliminating the risks of terrorist attacks or natural disasters as well as an increase in the security of mass events and critical infrastructure requires the application of modern technologies. Therefore there is a proposal to construct a tool that integrates video signals transmitted by devices that are a part of video monitoring systems functioning in Poland. The article presents selected results of research conducted by the Police Academy in Szczytno under the implemented project for national defense and security on "Video Signals Integrator" Acronym - VSI. Project Leader: Warsaw University of Technology. The consortium: Police Academy in Szczytno, Atende Software Ltd., VORTEX Ltd. No. DOBBio7/ 01/02/2015 funded by the National Centre for Research and Development.

  1. Results from the National Aeronautics and Space Administration remote sensing experiments in the New York Bight, 7-17 April 1975

    NASA Technical Reports Server (NTRS)

    Hall, J. B., Jr. (Compiler); Pearson, A. O. (Compiler)

    1977-01-01

    A cooperative operation was conducted in the New York Bight to evaluate the role of remote sensing technology to monitor ocean dumping. Six NASA remote sensing experiments were flown on the C-54, U-2, and C-130 NASA aircraft, while NOAA obtained concurrent sea truth information using helicopters and surface platforms. The experiments included: (1) a Radiometer/Scatterometer (RADSCAT), (2) an Ocean Color Scanner (OCS), (3) a Multichannel Ocean Color Sensor (MOCS), (4) four Hasselblad cameras, (5) an Ebert spectrometer; and (6) a Reconafax IV infrared scanner and a Precision Radiation Thermometer (PRT-5). The results of these experiments relative to the use of remote sensors to detect, quantify, and determine the dispersion of pollutants dumped into the New York Bight are presented.

  2. High frequency transcutaneous electrical nerve stimulation with diphenidol administration results in an additive antiallodynic effect in rats following chronic constriction injury.

    PubMed

    Lin, Heng-Teng; Chiu, Chong-Chi; Wang, Jhi-Joung; Hung, Ching-Hsia; Chen, Yu-Wen

    2015-03-04

    The impact of coadministration of transcutaneous electrical nerve stimulation (TENS) and diphenidol is not well established. Here we estimated the effects of diphenidol in combination with TENS on mechanical allodynia and tumor necrosis factor-α (TNF-α) expression. Using an animal chronic constriction injury (CCI) model, the rat was estimated for evidence of mechanical sensitivity via von Frey hair stimulation and TNF-α expression in the sciatic nerve using the ELISA assay. High frequency (100Hz) TENS or intraperitoneal injection of diphenidol (2.0μmol/kg) was applied daily, starting on postoperative day 1 (POD1) and lasting for the next 13 days. We demonstrated that both high frequency TENS and diphenidol groups had an increase in mechanical withdrawal thresholds of 60%. Coadministration of high frequency TENS and diphenidol gives better results of paw withdrawal thresholds in comparison with high frequency TENS alone or diphenidol alone. Both diphenidol and coadministration of high frequency TENS with diphenidol groups showed a significant reduction of the TNF-α level compared with the CCI or HFS group (P<0.05) in the sciatic nerve on POD7, whereas the CCI or high frequency TENS group exhibited a higher TNF-α level than the sham group (P<0.05). Our resulting data revealed that diphenidol alone, high frequency TENS alone, and the combination produced a reduction of neuropathic allodynia. Both diphenidol and the combination of diphenidol with high frequency TENS inhibited TNF-α expression. A moderately effective dose of diphenidol appeared to have an additive effect with high frequency TENS. Therefore, multidisciplinary treatments could be considered for this kind of mechanical allodynia.

  3. Aceneuramic Acid Extended Release Administration Maintains Upper Limb Muscle Strength in a 48-week Study of Subjects with GNE Myopathy: Results from a Phase 2, Randomized, Controlled Study

    PubMed Central

    Argov, Zohar; Caraco, Yoseph; Lau, Heather; Pestronk, Alan; Shieh, Perry B.; Skrinar, Alison; Koutsoukos, Tony; Ahmed, Ruhi; Martinisi, Julia; Kakkis, Emil

    2016-01-01

    Background: GNE Myopathy (GNEM) is a progressive adult-onset myopathy likely caused by deficiency of sialic acid (SA) biosynthesis. Objective: Evaluate the safety and efficacy of SA (delivered by aceneuramic acid extended-release [Ace-ER]) as treatment for GNEM. Methods: A Phase 2, randomized, double-blind, placebo-controlled study evaluating Ace-ER 3 g/day or 6 g/day versus placebo was conducted in GNEM subjects (n = 47). After the first 24 weeks, placebo subjects crossed over to 3 g/day or 6 g/day for 24 additional weeks (dose pre-assigned during initial randomization). Assessments included serum SA, muscle strength by dynamometry, functional assessments, clinician- and patient-reported outcomes, and safety. Results: Dose-dependent increases in serum SA levels were observed. Supplementation with Ace-ER resulted in maintenance of muscle strength in an upper extremity composite (UEC) score at 6 g/day compared with placebo at Week 24 (LS mean difference +2.33 kg, p = 0.040), and larger in a pre-specified subgroup able to walk ≥200 m at Screening (+3.10 kg, p = 0.040). After cross-over, a combined 6 g/day group showed significantly better UEC strength than a combined 3 g/day group (+3.46 kg, p = 0.0031). A similar dose-dependent response was demonstrated within the lower extremity composite score, but was not significant (+1.06 kg, p = 0.61). The GNEM-Functional Activity Scale demonstrated a trend improvement in UE function and mobility in a combined 6 g/day group compared with a combined 3 g/day group. Patients receiving Ace-ER tablets had predominantly mild-to-moderate AEs and no serious adverse events. Conclusions: This is the first clinical study to provide evidence that supplementation with SA delivered by Ace-ER may stabilize muscle strength in individuals with GNEM and initiating treatment earlier in the disease course may lead to better outcomes. PMID:27854209

  4. Sustaining Control of Schistosomiasis Mansoni in Western Côte d’Ivoire: Results from a SCORE Study, One Year after Initial Praziquantel Administration

    PubMed Central

    Assaré, Rufin K.; Tian-Bi, Yves-Nathan T.; Yao, Patrick K.; N’Guessan, Nicaise A.; Ouattara, Mamadou; Yapi, Ahoua; Coulibaly, Jean T.; Meïté, Aboulaye; Hürlimann, Eveline; Knopp, Stefanie; Utzinger, Jürg; N’Goran, Eliézer K.

    2016-01-01

    Background The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) has launched several large-scale trials to determine the best strategies for gaining and sustaining control of schistosomiasis and transitioning toward elimination. In Côte d’Ivoire, a 5-year cluster-randomized trial is being implemented in 75 schools to sustain the control of schistosomiasis mansoni. We report Schistosoma mansoni infection levels in children one year after the initial school-based treatment (SBT) with praziquantel and compare with baseline results to determine the effect of the intervention. Methodology The baseline cross-sectional survey was conducted in late 2011/early 2012 and the first follow-up in May 2013. Three consecutive stool samples were collected from 9- to 12-year-old children in 75 schools at baseline and 50 schools at follow-up. Stool samples were subjected to duplicate Kato-Katz thick smears. Directly observed treatment (DOT) coverage of the SBT was assessed and the prevalence and intensity of S. mansoni infection compared between baseline and follow-up. Principal Findings The S. mansoni prevalence in the 75 schools surveyed at baseline was 22.1% (95% confidence interval (CI): 19.5–24.4%). The DOT coverage was 84.2%. In the 50 schools surveyed at baseline and one year after treatment, the overall prevalence of S. mansoni infection decreased significantly from 19.7% (95% CI: 18.5–20.8%) to 12.8% (95% CI: 11.9–13.8%), while the arithmetic mean S. mansoni eggs per gram of stool (EPG) among infected children slightly increased from 92.2 EPG (95% CI: 79.2–105.3 EPG) to 109.3 EPG (95% CI: 82.7–135.9 EPG). In two of the 50 schools, the prevalence increased significantly, despite a DOT coverage of >75%. Conclusions/Significance One year after the initial SBT, the S. mansoni prevalence had decreased. Despite this positive trend, an increase was observed in some schools. Moreover, the infection intensity among S. mansoni-infected children

  5. Long-term administration of cocaine or serotonin reuptake inhibitors results in anatomical and neurochemical changes in noradrenergic, dopaminergic, and serotonin pathways.

    PubMed

    Horne, Malcolm K; Lee, Joohyung; Chen, Feng; Lanning, Katherine; Tomas, Doris; Lawrence, Andrew J

    2008-08-01

    The catechol and indole pathways are important components underlying plasticity in the frontal cortex and basal ganglia. This study demonstrates that administering rats either cocaine or a selective serotonin (or 5-hydroxytryptamine; 5-HT) reuptake inhibitor (SSRI) for 16 weeks results in reduced density of dopaminergic and noradrenergic terminals in the striatum and olfactory bulb, respectively, reflecting pruning of the terminal arbor of ventral midbrain dopaminergic and locus coeruleus noradrenergic neurones. In the striatum of cocaine-treated animals, basal dopamine levels, as well as cocaine-induced dopamine release, is diminished compared with controls. In contrast, serotonergic fibers, projecting from the raphe, sprout and have increased terminal density in the lateral septal nucleus and frontal cortex, following long-term cocaine or SSRI treatment. This is associated with elevated basal 5-HT and enhanced cocaine-induced 5-HT release in the frontal cortex. The anatomical and neurochemical changes in serotonergic fibers following cocaine or SSRI treatment may be explained by attenuated 5-HT(1A) autoreceptor function in the raphe. This study demonstrates extensive plasticity in the morphology and neurochemistry of the catechol and indole pathways that contribute to drug-induced plasticity of the corticostriatal (and other) projections. Moreover, our data suggest that drug-induced plastic adaptation is anatomically widespread and consequently, likely to have multiple and complex consequences.

  6. Existence of vimentin and GFAP protein expressions as a result of 2-Methoxyethanol administration in cerebral cortex tissue of Swiss Webster mice (Mus musculus): an immunohistochemical analysis.

    PubMed

    Irnidayanti, Yulia

    2014-07-01

    Une of the plastic-based materials widely used in the plastics industry in various countries is ester phthalate. This compound will be oxidized in the body into 2-methoxyethanol (2-ME). The effect of 2-ME on human health and environment depends on the number, duration and the frequency of exposure. Recently, the incidence of brain damage tends to increase. In the last decade, it has been widely reported the negative effects of chemical pollutants to the environment. The aim of this study were to know the existence of the expression of Vimentin and GFAP proteins caused by 2-ME on the histological structure of the cerebral cortex of mice fetal during the prenatal period on gestation day 14 (GD 14) and day 18 (GD 18). The 2-ME compound was injected intraperitoneally with a dose of 7.5 mmol kg(-1) of body weight at GD-10. The result showed that there is a change in existence Vimentin protein in the cerebral cortex fetal of treated mice at GD 14, which is very conspicuous. Meanwhile, a change in existence of GFAP protein in cerebral cortex fetal of treated mice at GD 14, have relatively no difference from controls and no impact on histological structure changes of the cerebral corteks at GD 14. The change in existence of Vimentin protein in the cerebral cortex fetal of treated mice at GD 14 have an impact on histological structure of the cerebral cortex of mice treated at GD 18. It is believed that the impact is due to the effects of 2-methoxyethanol.

  7. Route of administration for erythropoiesis-stimulating agents: patient and nursing considerations.

    PubMed

    Holloway, Maggie

    2007-01-01

    Several clinical studies have indicated that compared with intravenous (IV) administration, subcutaneous (SC) administration of Epoetin alfa may result in a dose-sparing effect in patients on hemodialysis. However, data also indicate wide inter-patient variability in response, with many patients requiring the same or a higher dose following conversion to SC administration. Convenience favors IV administration of Epoetin alfa in patients on hemodialysis, and patient preferences and comfort should also be primary considerations. For patients who prefer SC injections, the nurse's coordination of the required dosing, administration, and operational factors is key to maintaining and improving anemia-related outcomes.

  8. Inhibition of ovulation by administration of estetrol in combination with drospirenone or levonorgestrel: Results of a phase II dose-finding pilot study

    PubMed Central

    Duijkers, Ingrid J.M.; Klipping, Christine; Zimmerman, Yvette; Appels, Nicole; Jost, Maud; Maillard, Catherine; Mawet, Marie; Foidart, Jean-Michel; Coelingh Bennink, Herjan J. T.

    2015-01-01

    Abstract Objectives The aim of the study was to evaluate the efficacy of different dosages of estetrol (E4) combined with one of two progestins in suppressing the pituitary–ovarian axis and ovulation in healthy premenopausal women. Methods This was an open, parallel, phase II, dose-finding, pilot study performed in healthy women aged 18 to 35 years with a documented ovulatory cycle before treatment. For three consecutive cycles in a 24/4-day regimen, participants received 5 mg or 10 mg E4/3 mg drospirenone (DRSP); 5 mg, 10 mg or 20 mg E4/150 μg levonorgestrel; or 20 μg ethinylestradiol (EE)/3 mg DRSP as comparator. Pituitary–ovarian axis activity and the occurrence of ovulation were evaluated by monitoring follicular size, serum levels of follicle-stimulating hormone, luteinising hormone, estradiol and progesterone during treatment cycles 1 and 3. Endometrial thickness was evaluated throughout the trial, and the return of ovulation was evaluated after the last intake of medication. Results A total of 109 women were included in the trial. No ovulation occurred in any treatment group. Ovarian activity inhibition seemed proportional to the E4 dosage: the highest suppression was observed in the 20 mg E4 group and was very similar to that observed with EE/DRSP. Endometrial thickness was suppressed to the same extent in all groups. Post-treatment ovulation occurred in all participants between 17 and 21 days after the last active treatment. The study combinations were well tolerated and safe. Conclusions Combined with a progestin, E4 adequately suppresses ovarian activity, particularly when given at a dosage above 10 mg/day. Chinese Abstract 摘要 目的 这项研究的目的是评估不同剂量的雌四醇联合两种孕激素中的其中一种对垂体-卵巢轴以及健康的绝经前妇女的排卵方面的抑制疗效。 方法 这是一个在18到35岁的健康女性中进行的开放的、平行的,关于II期药物剂量探索的初步研究,这些女

  9. Novice Administrators: Psychological and Physiological Effects.

    ERIC Educational Resources Information Center

    Schmidt, Linda J.; Kosmoski, Georgia J.; Pollack, Dennis R.

    Novice school administrators find that demands for excellence have grown while budgets have shrunk. This paper reports on a study that examined the stress levels of beginning administrators. Two of the key questions for the study--Is the stress experienced by new school administrators manageable or out of control? and Does the job put beginning…

  10. Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion.

    PubMed

    Schwendt, Marek; Rocha, Angelica; See, Ronald E; Pacchioni, Alejandra M; McGinty, Jacqueline F; Kalivas, Peter W

    2009-11-01

    Chronic abuse of methamphetamine leads to cognitive dysfunction and high rates of relapse, paralleled by significant changes of brain dopamine and serotonin neurotransmission. Previously, we found that rats with extended access to methamphetamine self-administration displayed enhanced methamphetamine-primed reinstatement of drug-seeking and cognitive deficits relative to limited access animals. The present study investigated whether extended access to methamphetamine self-administration produced abnormalities in dopamine and serotonin systems in rat forebrain. Rats self-administered methamphetamine (0.02-mg/i.v. infusion) during daily 1-h sessions for 7 to 10 days, followed by either short- (1-h) or long-access (6-h) self-administration for 12 to 14 days. Lever responding was extinguished for 2 weeks before either reinstatement testing or rapid decapitation and tissue dissection. Tissue levels of monoamine transporters and markers of methamphetamine-induced toxicity were analyzed in several forebrain areas. Long-access methamphetamine self-administration resulted in escalation of daily drug intake ( approximately 7 mg/kg/day) and enhanced drug-primed reinstatement compared with the short-access group. Furthermore, long-, but not short-access to self-administered methamphetamine resulted in persistent decreases in dopamine transporter (DAT) protein levels in the prefrontal cortex and dorsal striatum. In contrast, only minor alterations in the tissue levels of dopamine or its metabolites were found, and no changes in markers specific for dopamine terminals or glial cell activation were detected. Our findings suggest that persistent methamphetamine seeking is associated with region-selective changes in DAT levels without accompanying monoaminergic neurotoxicity. Greater understanding of the neuroadaptations underlying persistent methamphetamine seeking and cognitive deficits could yield targets suitable for future therapeutic interventions.

  11. Patience: A Key Word when Talking with Teachers and Administrators

    ERIC Educational Resources Information Center

    McGee, Christy D.

    2012-01-01

    Summer activities have grown old. Going swimming has lost its allure, and boredom has set in. No matter how well parents have planned interesting and educational activities for the summer months or how much they have enjoyed the freedom from stricter schedules and more rigid bedtimes, it is time to transition back to the routines of the school…

  12. Quantum Key Distribution

    NASA Astrophysics Data System (ADS)

    Hughes, Richard

    2004-05-01

    Quantum key distribution (QKD) uses single-photon communications to generate the shared, secret random number sequences that are used to encrypt and decrypt secret communications. The unconditional security of QKD is based on the interplay between fundamental principles of quantum physics and information theory. An adversary can neither successfully tap the transmissions, nor evade detection (eavesdropping raises the key error rate above a threshold value). QKD could be particularly attractive for free-space optical communications, both ground-based and for satellites. I will describe a QKD experiment performed over multi-kilometer line-of-sight paths, which serves as a model for a satellite-to-ground key distribution system. The system uses single-photon polarization states, without active polarization switching, and for the first time implements the complete BB84 QKD protocol including, reconciliation, privacy amplification and the all-important authentication stage. It is capable of continuous operation throughout the day and night, achieving the self-sustaining production of error-free, shared, secret bits. I will also report on the results of satellite-to-ground QKD modeling.

  13. Identifying tier one key suppliers.

    PubMed

    Wicks, Steve

    2013-01-01

    In today's global marketplace, businesses are becoming increasingly reliant on suppliers for the provision of key processes, activities, products and services in support of their strategic business goals. The result is that now, more than ever, the failure of a key supplier has potential to damage reputation, productivity, compliance and financial performance seriously. Yet despite this, there is no recognised standard or guidance for identifying a tier one key supplier base and, up to now, there has been little or no research on how to do so effectively. This paper outlines the key findings of a BCI-sponsored research project to investigate good practice in identifying tier one key suppliers, and suggests a scalable framework process model and risk matrix tool to help businesses effectively identify their tier one key supplier base.

  14. 75 FR 20364 - Public Buildings Service; Key Largo Beacon Annex Site; Key Largo, FL; Transfer of Property

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-19

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Public Buildings Service; Key Largo Beacon Annex Site; Key Largo, FL; Transfer of Property..., identified as Key Largo Beacon Annex Site, Key Largo, FL to the U.S. Fish and Wildlife Service, Department...

  15. Quantum key management

    DOEpatents

    Hughes, Richard John; Thrasher, James Thomas; Nordholt, Jane Elizabeth

    2016-11-29

    Innovations for quantum key management harness quantum communications to form a cryptography system within a public key infrastructure framework. In example implementations, the quantum key management innovations combine quantum key distribution and a quantum identification protocol with a Merkle signature scheme (using Winternitz one-time digital signatures or other one-time digital signatures, and Merkle hash trees) to constitute a cryptography system. More generally, the quantum key management innovations combine quantum key distribution and a quantum identification protocol with a hash-based signature scheme. This provides a secure way to identify, authenticate, verify, and exchange secret cryptographic keys. Features of the quantum key management innovations further include secure enrollment of users with a registration authority, as well as credential checking and revocation with a certificate authority, where the registration authority and/or certificate authority can be part of the same system as a trusted authority for quantum key distribution.

  16. Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study

    PubMed Central

    2014-01-01

    Introduction The MRE11A-RAD50-Nibrin (MRN) complex plays several critical roles related to repair of DNA double-strand breaks. Inherited mutations in the three components predispose to genetic instability disorders and the MRN genes have been implicated in breast cancer susceptibility, but the underlying data are not entirely convincing. Here, we address two related questions: (1) are some rare MRN variants intermediate-risk breast cancer susceptibility alleles, and if so (2) do the MRN genes follow a BRCA1/BRCA2 pattern wherein most susceptibility alleles are protein-truncating variants, or do they follow an ATM/CHEK2 pattern wherein half or more of the susceptibility alleles are missense substitutions? Methods Using high-resolution melt curve analysis followed by Sanger sequencing, we mutation screened the coding exons and proximal splice junction regions of the MRN genes in 1,313 early-onset breast cancer cases and 1,123 population controls. Rare variants in the three genes were pooled using bioinformatics methods similar to those previously applied to ATM, BRCA1, BRCA2, and CHEK2, and then assessed by logistic regression. Results Re-analysis of our ATM, BRCA1, and BRCA2 mutation screening data revealed that these genes do not harbor pathogenic alleles (other than modest-risk SNPs) with minor allele frequencies >0.1% in Caucasian Americans, African Americans, or East Asians. Limiting our MRN analyses to variants with allele frequencies of <0.1% and combining protein-truncating variants, likely spliceogenic variants, and key functional domain rare missense substitutions, we found significant evidence that the MRN genes are indeed intermediate-risk breast cancer susceptibility genes (odds ratio (OR) = 2.88, P = 0.0090). Key domain missense substitutions were more frequent than the truncating variants (24 versus 12 observations) and conferred a slightly higher OR (3.07 versus 2.61) with a lower P value (0.029 versus 0.14). Conclusions These data establish

  17. Modular Connector Keying Concept

    NASA Technical Reports Server (NTRS)

    Ishman, Scott; Dukes, Scott; Warnica, Gary; Conrad, Guy; Senigla, Steven

    2013-01-01

    For panel-mount-type connectors, keying is usually "built-in" to the connector body, necessitating different part numbers for each key arrangement. This is costly for jobs that require small quantities. This invention was driven to provide a cost savings and to reduce documentation of individual parts. The keys are removable and configurable in up to 16 combinations. Since the key parts are separate from the connector body, a common design can be used for the plug, receptacle, and key parts. The keying can then be set at the next higher assembly.

  18. Group key management

    SciTech Connect

    Dunigan, T.; Cao, C.

    1997-08-01

    This report describes an architecture and implementation for doing group key management over a data communications network. The architecture describes a protocol for establishing a shared encryption key among an authenticated and authorized collection of network entities. Group access requires one or more authorization certificates. The implementation includes a simple public key and certificate infrastructure. Multicast is used for some of the key management messages. An application programming interface multiplexes key management and user application messages. An implementation using the new IP security protocols is postulated. The architecture is compared with other group key management proposals, and the performance and the limitations of the implementation are described.

  19. The Key to Security.

    ERIC Educational Resources Information Center

    Kennedy, Mike

    2001-01-01

    Provides tips on using low-tech, traditional key and lock systems for effectively securing university and college facilities. Discusses providing keys with utility patents as well as the need to design doors that offer greater deterrence to vandalism. (GR)

  20. Keys to Scholarship

    ERIC Educational Resources Information Center

    Hebert, Terri

    2011-01-01

    Up ahead, a foreboding wooden door showing wear from passage of earlier travelers is spotted. As the old porch light emits a pale yellow glow, a key ring emerges from deep inside the coat pocket. Searching for just the right key, the voyager settles on one that also shows age. As the key enters its receptacle and begins to turn, a clicking noise…

  1. Work Keys USA.

    ERIC Educational Resources Information Center

    Work Keys USA, 1998

    1998-01-01

    "Work Keys" is a comprehensive program for assessing and teaching workplace skills. This serial "special issue" features 18 first-hand reports on Work Keys projects in action in states across North America. They show how the Work Keys is helping businesses and educators solve the challenge of building a world-class work force.…

  2. Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH

    PubMed Central

    Mizrahi, Meir; Shabat, Yehudit; Ben Ya’acov, Ami; Lalazar, Gadi; Adar, Tomer; Wong, Victor; Muller, Brian; Rawlin, Grant; Ilan, Yaron

    2012-01-01

    Background Nonalcoholic steatohepatitis (NASH) is considered to be part of the nonalcoholic fatty liver disorders and its incidence is increasing. Imm124-E (Immuron Ltd, Melbourne, Australia), containing hyperimmune bovine colostrum, has been shown to exert an immunomodulatory effect and to alleviate target organ damage in animal models of NASH. The aim of our study was to determine the safety and efficacy of oral administration of Imm124-E to patients with insulin resistance and NASH. Methods In an open-label trial, ten patients with biopsy-proven NASH and insulin resistance were orally treated with Imm124-E for 30 days. Results Oral administration of Imm124-E was safe, and no side effects were noted. Alleviation of insulin resistance was reflected by significantly improved hemoglobin A1c (HbA1c) values in all ten treated patients. For between five and eight responders, the following effects were noted: a decrease in fasting glucose levels; improved oral glucose tolerance test (OGGT) and homeostatic model assessment insulin resistance (HOMA) scores; and alleviation in lipid profile. These effects were accompanied by increased serum levels of glucagon-like peptide 1 (GLP-1), adiponectin and T regulatory cells. Conclusion Hyperimmune colostrum alleviates NASH. PMID:23293533

  3. Key scientific findings and policy- and health-relevant insights from the U.S. Environmental Protection Agency's Particulate Matter Supersites Program and related studies: an integration and synthesis of results.

    PubMed

    Solomon, Paul A; Hopke, Philip K; Froines, John; Scheffe, Richard

    2008-01-01

    In 1998, the U.S. Environmental Protection Agency (EPA) initiated a major air quality program known as the Particulate Matter (PM) Supersites Program. The Supersites Program was a multiyear, $27 million air quality monitoring program consisting of eight regional air quality projects located throughout the United States, each with differing atmospheric pollution conditions resulting from variations in source emissions and meteorology. The overall goal of the program was to elucidate source-receptor relationships and atmospheric processes leading to PM accumulation on urban and regional scales; thus providing the scientific underpinning for modeling and data analysis efforts to support State Implementation Plans and more effective risk management approaches for PM. The program had three main objectives: (1) conduct methods development and evaluation, (2) characterize ambient PM, and (3) support health effects and exposure research. This paper provides a synthesis of key scientific findings from the Supersites Program and related studies. EPA developed 16 science/policy-relevant questions in conjunction with state and other federal agencies, Regional Planning Organizations, and the private sector. These questions were addressed to the extent possible, even given the vast amount of new information available from the Supersites Program, in a series of papers published as a special issue of the Journal of Air & Waste Management Association (February 2008). This synthesis also includes discussions of: (1) initial Supersites Program support for air quality management efforts in specific locations throughout the United States; (2) selected policy-relevant insights, based on atmospheric sciences findings, useful to air quality managers and decision makers planning emissions management strategies to address current and future PM National Ambient Air Quality Standards (NAAQS) and network planning and implementation; (3) selected health-relevant insights interpreted from

  4. Paediatric pharmacokinetics: key considerations

    PubMed Central

    Batchelor, Hannah Katharine; Marriott, John Francis

    2015-01-01

    A number of anatomical and physiological factors determine the pharmacokinetic profile of a drug. Differences in physiology in paediatric populations compared with adults can influence the concentration of drug within the plasma or tissue. Healthcare professionals need to be aware of anatomical and physiological changes that affect pharmacokinetic profiles of drugs to understand consequences of dose adjustments in infants and children. Pharmacokinetic clinical trials in children are complicated owing to the limitations on blood sample volumes and perception of pain in children resulting from blood sampling. There are alternative sampling techniques that can minimize the invasive nature of such trials. Population based models can also limit the sampling required from each individual by increasing the overall sample size to generate robust pharmacokinetic data. This review details key considerations in the design and development of paediatric pharmacokinetic clinical trials. PMID:25855821

  5. Paediatric pharmacokinetics: key considerations.

    PubMed

    Batchelor, Hannah Katharine; Marriott, John Francis

    2015-03-01

    A number of anatomical and physiological factors determine the pharmacokinetic profile of a drug. Differences in physiology in paediatric populations compared with adults can influence the concentration of drug within the plasma or tissue. Healthcare professionals need to be aware of anatomical and physiological changes that affect pharmacokinetic profiles of drugs to understand consequences of dose adjustments in infants and children. Pharmacokinetic clinical trials in children are complicated owing to the limitations on blood sample volumes and perception of pain in children resulting from blood sampling. There are alternative sampling techniques that can minimize the invasive nature of such trials. Population based models can also limit the sampling required from each individual by increasing the overall sample size to generate robust pharmacokinetic data. This review details key considerations in the design and development of paediatric pharmacokinetic clinical trials.

  6. Centralized administrative services management.

    PubMed

    Freed, D H

    1994-06-01

    Virtually every hospital has imposed guidelines or controls on one or more administrative service expenses. However, the actual deployment of such strategies is often voluntary, decentralized, disjointed and episodic. An alternative approach is to cluster administrative elements across hospital departments and make them the responsibility of a dedicated manager. This approach treats administrative services as an organizing principle with uniform, predictable standards of service and cost. Customer requirements for products and services are met without the need for them to physically manage that process. Materiel managers can demonstrate a leadership role by applying their professionalism and know-how to a set of products and services traditionally ignored or dealt with in an uncoordinated manner. While some initial resistance can be expected as traditional barriers are disassembled, the results should be very rewarding for the hospital and materiel manager alike.

  7. Opportunities for administrators to promote disease management.

    PubMed

    Kash, Bita A; Gamm, Larry D; Bolin, Jane Nelson; Peck, B Mitchell

    2005-01-01

    Studies of disease management (DM) have shown that patients who participate in such programs achieve better health status and make fewer emergency room visits. Private and government payers have recently increased their efforts to promote DM initiatives through financial incentives to healthcare providers. This article explores opportunities for administrators of health services organizations (HSO) to promote DM in the current political and economic environment. Our survey of professionals (DM leaders, physicians, and DM nurses) in six DM programs reveals these professionals' assessments of the key players and resources that they deem important to their respective DM programs. They view DM programs as heavily dependent on the support of physicians, nurses, and health plan leaders but relatively less so on the support of HSO administrators- a situation that may suggest opportunities for administrators to take on greater leadership in moving the HSO toward developing DM programs. Survey results also indicate a strong need for the integration of resources such as communication systems, electronic medical records, and DM reporting. Taken collectively, these needs suggest a number of strategies for the administrator to play a larger role in supporting the adoption and effective implementation of DM. In the article, we propose that DM programs can benefit substantially from an administrator who can demonstrate a thorough knowledge of DM-related government and private-payer initiatives and who has the ability to provide leadership to develop and implement viable DM programs. Valued contributions that the administrator should bring to the table include support of standardized DM processes, use of practice guidelines, and provision of pertinent information systems.

  8. Navigating Academic Waters: The Art of Administration.

    ERIC Educational Resources Information Center

    Powell, Lawrence Clark

    1986-01-01

    This essay relates author's experiences as librarian, educator, and administrator. Discussion covers elements of good librarianship, art of administration, climate in academic libraries, staff motivation in midst of technological changes, right person in wrong place or wrong person at wrong time, and associations with Keyes Metcalf and Luther H.…

  9. Progress and goals for INMM ASC N15 consensus standard ""Administrative practices for the determination and reporting of results of non-destructive assay measurements of nuclear material in situ for safeguards nuclear criticality safety and other purposes

    SciTech Connect

    Bracken, David S; Lamb, Frank W

    2009-01-01

    This paper will discuss the goals and progress to date on the development of INMM Accredited Standard Committee (ASC) N15 consensus standard Administrative Practices for the Determination and Reporting of Results of Non-Destructive Assay Measurements of Nuclear Material in situ for Safeguards, Nuclear Criticality Safety, and Other Purposes. This standard will define administrative practices in the areas of data generation and reporting of NDA assay of holdup deposits with consideration of the stakeholders of the reported results. These stakeholders may include nuclear material accounting and safeguards, nuclear criticality safety, waste management, health physics, facility characterization, authorization basis, radiation safety, and site licensing authorities. Stakeholder input will be solicited from interested parties and incorporated during the development of the document. Currently only one consensus standard exists that explicitly deals with NDA holdup measurements: ASTM C1455 Standard Test Method for Nondestructive Assay of Special Nuclear Material Holdup Using Gamma-Ray Spectroscopic Methods. The ASTM International standard emphasizes the activities involved in actually making measurements, and was developed by safeguards and NDA experts. This new INMM ASC N15 standard will complement the existing ASTM international standard. One of the largest driving factors for writing this new standard was the recent emphasis on in situ NDA measurements by the safeguards community due to the Defense Nuclear Facility Safety Board (DNFSB) recommendation 2007-1 on in situ NDA measurements. Specifically, DNFSB recommendation 2007-1 referenced the lack of programmatic requirements for accurate in situ measurements and the use of measurement results for compliance with safety based requirements. That being the case, this paper will also discuss the progress made on the Implementation Plan for Defense Nuclear Facilities Safety Board Recommendation 2007-1 Safety-Related In Situ

  10. Key Stage 3 Pupils' Perception of Music

    ERIC Educational Resources Information Center

    Button, Stuart

    2006-01-01

    The key aim of the research summarised in this article was to examine pupils' perception of music and to determine whether or not these perceptions were the same for both female and male pupils. The empirical enquiry consisted of the administration of a questionnaire to six secondary schools in the north-east of England followed by semi-structured…

  11. Optical key system

    DOEpatents

    Hagans, Karla G.; Clough, Robert E.

    2000-01-01

    An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

  12. Optical key system

    SciTech Connect

    Hagans, K.G.; Clough, R.E.

    2000-04-25

    An optical key system comprises a battery-operated optical key and an isolated lock that derives both its operating power and unlock signals from the correct optical key. A light emitting diode or laser diode is included within the optical key and is connected to transmit a bit-serial password. The key user physically enters either the code-to-transmit directly, or an index to a pseudorandom number code, in the key. Such person identification numbers can be retained permanently, or ephemeral. When a send button is pressed, the key transmits a beam of light modulated with the password information. The modulated beam of light is received by a corresponding optical lock with a photovoltaic cell that produces enough power from the beam of light to operate a password-screen digital logic. In one application, an acceptable password allows a two watt power laser diode to pump ignition and timing information over a fiberoptic cable into a sealed engine compartment. The receipt of a good password allows the fuel pump, spark, and starter systems to each operate. Therefore, bypassing the lock mechanism as is now routine with automobile thieves is pointless because the engine is so thoroughly disabled.

  13. Optimizing Requirements Decisions with KEYS

    NASA Technical Reports Server (NTRS)

    Jalali, Omid; Menzies, Tim; Feather, Martin

    2008-01-01

    Recent work with NASA's Jet Propulsion Laboratory has allowed for external access to five of JPL's real-world requirements models, anonymized to conceal proprietary information, but retaining their computational nature. Experimentation with these models, reported herein, demonstrates a dramatic speedup in the computations performed on them. These models have a well defined goal: select mitigations that retire risks which, in turn, increases the number of attainable requirements. Such a non-linear optimization is a well-studied problem. However identification of not only (a) the optimal solution(s) but also (b) the key factors leading to them is less well studied. Our technique, called KEYS, shows a rapid way of simultaneously identifying the solutions and their key factors. KEYS improves on prior work by several orders of magnitude. Prior experiments with simulated annealing or treatment learning took tens of minutes to hours to terminate. KEYS runs much faster than that; e.g for one model, KEYS ran 13,000 times faster than treatment learning (40 minutes versus 0.18 seconds). Processing these JPL models is a non-linear optimization problem: the fewest mitigations must be selected while achieving the most requirements. Non-linear optimization is a well studied problem. With this paper, we challenge other members of the PROMISE community to improve on our results with other techniques.

  14. Safe administration of blood components.

    PubMed

    Hurrell, Katy

    The transfusion process has many stages, each involving different members of staff in different locations. This gives rise to a significant potential for errors. Nurses are involved in many of these stages and therefore require knowledge, skills and competence in the process to ensure the safety of patients. This third article in our five-part series on blood transfusion discusses the safe administration of blood components and the key principles to which nurses must adhere.

  15. An Alternative to Keys

    ERIC Educational Resources Information Center

    O'Hagan, James

    1977-01-01

    For the secondary school, the author discourages the use of dichotomous keys in favor of a punch-card system. The system is readily constructed by students for use in plant and animal classification. (CP)

  16. Public Key FPGA Software

    SciTech Connect

    Hymel, Ross

    2013-07-25

    The Public Key (PK) FPGA software performs asymmetric authentication using the 163-bit Elliptic Curve Digital Signature Algorithm (ECDSA) on an embedded FPGA platform. A digital signature is created on user-supplied data, and communication with a host system is performed via a Serial Peripheral Interface (SPI) bus. Software includes all components necessary for signing, including custom random number generator for key creation and SHA-256 for data hashing.

  17. Veterans Health Administration

    MedlinePlus

    ... code here VA » Veterans Health Administration Veterans Health Administration Marine Continues to Serve by Serving Veterans David ... Read more » VA Medical Centers The Veterans Health Administration is home to the United States’ largest integrated ...

  18. Training for Effective School Administrators.

    ERIC Educational Resources Information Center

    Cawelti, Gordon

    Forces of societal change have placed new demands on school administrators for skills to manage schools. The result has been an increasing realization of the need for improved university preparation programs and for more effective Human Resource Development (HRD) for practicing administrators. A growing body of research shows a very positive…

  19. Postmodernism in Higher Educational Administration

    ERIC Educational Resources Information Center

    Demaris, Michalyn C.; Kritsonis, William Allan

    2007-01-01

    Postmodernism has many inferences that can be applied to the theory and practice of higher educational administration. Today, in higher education administrators are continuously focused on strategies that will ensure the future of minority educational institutions. As a result postmodernism is an important factor in the future of higher…

  20. Lock and key colloids.

    PubMed

    Sacanna, S; Irvine, W T M; Chaikin, P M; Pine, D J

    2010-03-25

    New functional materials can in principle be created using colloids that self-assemble into a desired structure by means of a programmable recognition and binding scheme. This idea has been explored by attaching 'programmed' DNA strands to nanometre- and micrometre- sized particles and then using DNA hybridization to direct the placement of the particles in the final assembly. Here we demonstrate an alternative recognition mechanism for directing the assembly of composite structures, based on particles with complementary shapes. Our system, which uses Fischer's lock-and-key principle, employs colloidal spheres as keys and monodisperse colloidal particles with a spherical cavity as locks that bind spontaneously and reversibly via the depletion interaction. The lock-and-key binding is specific because it is controlled by how closely the size of a spherical colloidal key particle matches the radius of the spherical cavity of the lock particle. The strength of the binding can be further tuned by adjusting the solution composition or temperature. The composite assemblies have the unique feature of having flexible bonds, allowing us to produce flexible dimeric, trimeric and tetrameric colloidal molecules as well as more complex colloidal polymers. We expect that this lock-and-key recognition mechanism will find wider use as a means of programming and directing colloidal self-assembly.

  1. Paine Appointed Administrator

    NASA Technical Reports Server (NTRS)

    1969-01-01

    President Richard M. Nixon announcing the appointment of Dr. Thomas O. Paine as Administrator for the National Aeronautics and Space Administration. The ceremony was held at the White House. Paine had been serving as acting administrator. From left to right: President Richard M. Nixon NASA Administrator Dr. Thomas O. Paine Vice President Spiro T. Agnew

  2. Five Keys to Success

    ERIC Educational Resources Information Center

    Peddy, Walter J.

    2009-01-01

    The first year as a principal is filled with self-doubt. As one already knows, there is no book or guide that can fully prepare someone for what the principal's position entails. All first-year principals have to learn by doing. In this article, the author discusses five keys to success that will guide and help first-year principals with the…

  3. Validation of STA-Liatest D-Di assay for exclusion of pulmonary embolism according to the latest Clinical and Laboratory Standard Institute/Food and Drug Administration guideline. Results of a multicenter management study.

    PubMed

    Pernod, Gilles; Wu, Haifeng; de Maistre, Emmanuel; Lazarchick, John; Kassis, Jeannine; Aguilar, Carlos; Vera, Pascual M; Palareti, Gualtiero; D'Angelo, Armando

    2016-11-29

    Combined clinical pretest probability (PTP) and D-dimer testing have great diagnostic value for pulmonary embolism exclusion. To harmonize performance levels of D-dimer assays available on the market, the Clinical and Laboratory Standard Institute (CLSI) has published a guideline, endorsed by the US Food and Drug Administration (FDA). Such guideline specifies the ideal D-dimer assay characteristic and target population. This study was conducted following the CLSI guideline to upgrade the assay-intended use and obtain FDA clearance of STA-Liatest D-Di assay for pulmonary embolism exclusion in patient with low/moderate PTP. This was an international, multicenter, prospective nonrandomized, noninterventional clinical outcome management study conducted in a standard of care setting. D-dimer assay was performed in consecutive, ambulatory outpatients suspected of pulmonary embolism, with low/moderate PTP, and without medical conditions or in clinical settings known to alter default D-dimer values regardless of the presence of thrombosis using a threshold of 0.5 μg/ml (fibrinogen equivalent units) for venous thromboembolism exclusion. Results were used to determine test performance. Of 1141 patients who underwent D-dimer testing, 1060 had valid results and completed study as planned. STA-Liatest D-Di assay performance has exceeded the CLSI/FDA guidance requirements, with a sensitivity of 97.6% (95% confidence interval: 91.7-99.7%) and a negative predictive value of 99.7% (95% confidence interval: 99.0-100%). STA-Liatest D-Di assay has an excellent performance when used in combination with a PTP score in relevant patients and has the potential to minimize the economic healthcare burden avoiding unnecessary and expensive imaging tests.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The

  4. Bangladesh: giving girls the "key of keys".

    PubMed

    Chhabra, R

    1998-01-01

    In Bangladesh, 100 nongovernmental organizations (NGOs) have worked with the government to create approximately 52,000 nonformal schools for children who have never attended school or have dropped out. The Bangladesh Rural Advancement Committee (BRAC) alone has 34,000 nonformal education centers. The BRAC program has been particularly effective at increasing educational opportunities for girls, and BRAC is a major implementing agency of the agreement forged by the International Labor Organization and the UN Children's Fund with the Bangladesh Garment Manufacturers Export Association, which gives about 10,000 former child garment workers a meager stipend allowing them to study instead of work. BRAC, the Grameen Bank, and several other NGOs are also developing alternative income-generating methods to compete with the exploitative working conditions suffered by impoverished girls. BRAC now has more than a million students enrolled each year, 700,000 of whom are girls. Students participate in special condensed courses in classes that average 33 pupils (20 must be girls). Gender sensitivity is incorporated at every level. BRAC also relies on community participation in running the schools, and the flexible hours and imaginative curriculum have resulted in very high attendance rates. Government actions (making primary education compulsory and tripling education expenditure) have also resulted in increased primary enrollment while special programs seek to increase the number of girls in secondary schools.

  5. Identification of Key Barriers in Workforce Development

    SciTech Connect

    2008-03-31

    This report documents the identification of key barriers in the development of an adequate national security workforce as part of the National Security Preparedness Project, being performed under a Department of Energy/National Nuclear Security Administration grant. Many barriers exist that prevent the development of an adequate number of propertly trained national security personnel. Some barriers can be eliminated in a short-term manner, whereas others will involve a long-term strategy that takes into account public policy.

  6. Secure key distribution applications of chaotic lasers

    NASA Astrophysics Data System (ADS)

    Jiang, Ning; Xue, Chenpeng; Lv, Yunxin; Qiu, Kun

    2016-11-01

    Chaotic semiconductor laser is a good candidate for secure communication and high-speed true random bit generator, for its characteristics of broad bandwidth and prominent unpredictability. Based on the synchronization property and true random bit generation characteristic of chaotic semiconductor lasers, physical secure key distribution is available. In this work, we majorly show three key distribution schemes stemming from synchronized chaotic semiconductor lasers or chaos-based key exchange protocol. The numerical results demonstrate that the security of the chaos-synchronization-based key distribution scheme can be physically enhanced by adopting dynamic synchronization scheme or encrypted key generation, and that of key distribution with chaos-based key exchange protocol is dependent on the security of the exchange protocol and finally determined by the difficulty of regeneration the chaos system accurately.

  7. Transportation Security Administration

    MedlinePlus

    ... content Official website of the Department of Homeland Security Transportation Security Administration A - Z Index What Can I Bring? ... form Search the Site Main menu Administrator Travel Security Screening Special Procedures TSA Pre✓® Passenger Support Travel ...

  8. Administration on Aging

    MedlinePlus

    ... Federal Initiatives Career Opportunities Contact Us Administration on Aging (AoA) The Administration on Aging (AOA) is the ... themselves. Back to top Older Americans Act and Aging Network To meet the diverse needs of the ...

  9. Rehabilitation Services Administration

    MedlinePlus

    ... Contacts OSEP Reports & Resources RSA Welcome to RSA Rehabilitation Services Administration RSA Spotlight News Commissioner's Quarterly Newsletter ... The Office of Special Education and Rehabilitative Services’ Rehabilitation Services Administration is proud to announce the publication ...

  10. Administration on Aging

    MedlinePlus

    ... Administration on Aging Administration on Disabilities Center for Integrated Programs Center for Performance and Evaluation National Institute ... Project Aging Statistics Profile of Older Americans AGing Integrated Database (AGID) Census Data & Population Estimates Projected Future ...

  11. Legal and Administrative Language

    ERIC Educational Resources Information Center

    Schwarz, Hans

    1977-01-01

    A discussion of legal and administrative language, and the necessity for accurate translation of this language in the field of international relations. Topics treated are: characteristic features of legal and administrative terminology; the interpretation of it; and the technique of translating legal and administrative texts. (AMH)

  12. Women in Administration 1978.

    ERIC Educational Resources Information Center

    National Association of State Universities and Land Grant Colleges, Washington, DC. Office of Communications Services.

    In a survey by the National Association of State Universities and Land-Grant Colleges (NASULGC), women are shown to hold 2,905 of the 13,638 administrative positions reported by 106 major U.S. public universities--slightly more than 21 percent of the administrators at state and land-grant universities. The median number of women administrators at…

  13. School Business Administration.

    ERIC Educational Resources Information Center

    Jordan, K. Forbis; And Others

    This textbook reviews the principal concerns within each of 13 major responsibility areas in school business administration. The first chapter assesses the political, social, and economic context in which schools function and school administrators work. The role and function of the school business administrator within this context is addressed in…

  14. Public Key Infrastructure Study

    DTIC Science & Technology

    1994-04-01

    whom it was created. This may require that the ORA load the certificate onto a smart card or floppy disk. The ORA has no authority to generate...appropriate directory server and, possibly, sent to the ORA to be loaded onto the user’s disk, smart card or other token. Adding another PCA, adding a new CA...possibly on a smart card , a PCMCIA card or an encrypted diskette. He is also responsible for having his public key certified by a CA. 5-2 To have his

  15. Key drivers of airline loyalty.

    PubMed

    Dolnicar, Sara; Grabler, Klaus; Grün, Bettina; Kulnig, Anna

    2011-10-01

    This study investigates drivers of airline loyalty. It contributes to the body of knowledge in the area by investigating loyalty for a number of a priori market segments identified by airline management and by using a method which accounts for the multi-step nature of the airline choice process. The study is based on responses from 687 passengers. Results indicate that, at aggregate level, frequent flyer membership, price, the status of being a national carrier and the reputation of the airline as perceived by friends are the variables which best discriminate between travellers loyal to the airline and those who are not. Differences in drivers of airline loyalty for a number of segments were identified. For example, loyalty programs play a key role for business travellers whereas airline loyalty of leisure travellers is difficult to trace back to single factors. For none of the calculated models satisfaction emerged as a key driver of airline loyalty.

  16. Administrative Coaching Practices: Content, Personalization, and Support

    ERIC Educational Resources Information Center

    Hayashi, Christine A.

    2016-01-01

    This study surveys educators who have completed, or are in their second year of, an administrative coaching program that results in a California Clear Administrative Credential, also known as Tier II. The purpose of the study is to determine the perceptions of these educators regarding whether current practices in administrative coaching programs…

  17. Individual Innovativeness Levels of Educational Administrators

    ERIC Educational Resources Information Center

    Coklar, Ahmet Naci

    2012-01-01

    In the present study carried out with 190 educational administrators, the individual innovativeness of educational administrators was examined. As a result of the study, it was found out that the educational administrators considered themselves as early adaptors. It was also revealed that professional seniority was not important in terms of…

  18. Professional Development for Rhode Island School Administrators.

    ERIC Educational Resources Information Center

    Turley, James; Brittingham, Barbara E.

    This report presents the results of a survey of Rhode Island school administrators (n=523) and open-ended interviews of administrators (n=28) that would provide information for the design of leadership and staff development activities as part of Rhode Island's LEAD project--an attempt to improve the leadership capacity of school administrators.…

  19. The LCOGT Supernova Key Project

    NASA Astrophysics Data System (ADS)

    Howell, Dale Andrew; Arcavi, Iair; Hosseinzadeh, Griffin; McCully, Curtis; Valenti, Stefano; LCOGT Supernova Key Project

    2016-06-01

    We highlight results from the Las Cumbres Observatory Global Telescope (LCOGT) Supernova Key Project -- a 3 year program to obtain lightcurves and spectra of approximately 500 low-redshift SNe. LCOGT is a robotic network of elevent one and two meter telescopes spaced around the globe. We are involved in a variety of surveys, including the intermediate Palomar Transient Factory, LaSilla Quest, PESSTO, and KMTNet. Recent results include analysis of large samples of core-collaspe SNe, the largest sample of SNe Ibn, evidence of the progenitors of SNe Ia from companion shocking, and new findings about superluminious SNe.

  20. Key Results from the Oriented Scintillation Spectrometer Experiment

    DTIC Science & Technology

    1995-10-09

    of the expected range for Type II ( core collapse ) supernova. OSSE observed Cas A for a period of three weeks dur- ing 1992. Analysis of the OSSE data...of the E1:7 spectrum of the 1 arcmin radius compact nebula seen be- tween optical and 25 keV with imaging instruments. They conclude that the...accelerated electrons responsible for the emission in the OSSE band (i.e. up to at least 400 keV) must escape from the compact nebula and travel to large

  1. Administrators' perspectives of support for elementary science education

    NASA Astrophysics Data System (ADS)

    Hanegan, Nikki Notias

    This investigation examines administrators' perspectives of support for elementary science education through naturalistic inquiry methodologies. Determining how administrators, as instructional leaders, define and demonstrate support for innovative reform in one curriculum area, specifically in science, has a direct impact on teacher effectiveness to implement change and new curricula into classrooms. Six major areas of current literature were reviewed for this study. They were (1) the need for Elementary Science Education, (2) the current status of Elementary Science Education, (3) the need for science professional development, (4) key components for effective professional development implementation, (5) leadership for elementary science education, and (6) administrative support. These critical issues were selected to deepen the understanding and purpose of this study. As a result of emergent interviews, five major themes developed from this study. They are: (1) knowledge of science instruction and implementation, (2) demonstration of administrative leadership to promote science education, (3) providing necessary resources or materials, (4) providing professional development opportunities, and (5) fostering teacher leadership for science instruction. These themes are discussed with supporting evidence from respondent interviews and verified through teacher interviews, newsletters, web sites, school observations, or curriculum sources. Administrative support for elementary science education is defined as action taken to ascertain that students are receiving quality science instruction. Chapter Five includes a discussion on the effectiveness of managers versus leaders in science education reform. Administrators need more direct involvement and participation in professional development aimed at science education to develop leadership skills, science content knowledge, and tools necessary to develop leaders for future district and school planning to implement science

  2. The Keys to the White House

    ERIC Educational Resources Information Center

    Lichtman, Allan J.

    2012-01-01

    The Keys to the White House is a historically-based system for predicting the result of the popular vote in American presidential elections. The Keys system tracks the big picture of how well the party holding the White House has governed and does not shift with events of the campaign. This model gives specificity to the idea that it is…

  3. Simple Web-based interactive key development software (WEBiKEY) and an example key for Kuruna (Poaceae: Bambusoideae)1

    PubMed Central

    Attigala, Lakshmi; De Silva, Nuwan I.; Clark, Lynn G.

    2016-01-01

    Premise of the study: Programs that are user-friendly and freely available for developing Web-based interactive keys are scarce and most of the well-structured applications are relatively expensive. WEBiKEY was developed to enable researchers to easily develop their own Web-based interactive keys with fewer resources. Methods and Results: A Web-based multiaccess identification tool (WEBiKEY) was developed that uses freely available Microsoft ASP.NET technologies and an SQL Server database for Windows-based hosting environments. WEBiKEY was tested for its usability with a sample data set, the temperate woody bamboo genus Kuruna (Poaceae). Conclusions: WEBiKEY is freely available to the public and can be used to develop Web-based interactive keys for any group of species. The interactive key we developed for Kuruna using WEBiKEY enables users to visually inspect characteristics of Kuruna and identify an unknown specimen as one of seven possible species in the genus. PMID:27144109

  4. Advancing Administrative Supports for Research Development

    ERIC Educational Resources Information Center

    Briar-Lawson, Katharine; Korr, Wynne; White, Barbara; Vroom, Phyllis; Zabora, James; Middleton, Jane; Shank, Barbara; Schatz, Mona

    2008-01-01

    Research administrative supports must parallel and reinforce faculty initiatives in research grant procurement. This article features several types of developments that draw on presentations at the National Association of Deans and Directors of Schools of Social Work meetings. Key changes in social work programs are addressed, including the…

  5. Veterans Administration Databases

    Cancer.gov

    The Veterans Administration Information Resource Center provides database and informatics experts, customer service, expert advice, information products, and web technology to VA researchers and others.

  6. SSME Key Operations Demonstration

    NASA Technical Reports Server (NTRS)

    Anderson, Brian; Bradley, Michael; Ives, Janet

    1997-01-01

    A Space Shuttle Main Engine (SSME) test program was conducted between August 1995 and May 1996 using the Technology Test Bed (TTB) Engine. SSTO vehicle studies have indicated that increases in the propulsion system operating range can save significant weight and cost at the vehicle level. This test program demonstrated the ability of the SSME to accommodate a wide variation in safe operating ranges and therefore its applicability to the SSTO mission. A total of eight tests were completed with four at Marshall Space Flight Center's Advanced Engine Test Facility and four at the Stennis Space Center (SSC) A-2 attitude test stand. Key demonstration objectives were: 1) Mainstage operation at 5.4 to 6.9 mixture ratio; 2) Nominal engine start with significantly reduced engine inlet pressures of 50 psia LOX and 38 psia fuel; and 3) Low power level operation at 17%, 22%, 27%, 40%, 45%, and 50% of Rated Power Level. Use of the highly instrumented TTB engine for this test series has afforded the opportunity to study in great detail engine system operation not possible with a standard SSME and has significantly contributed to a greater understanding of the capabilities of the SSME and liquid rocket engines in general.

  7. Nanofluids research: key issues.

    PubMed

    Wang, Liqiu; Fan, Jing

    2010-05-22

    Nanofluids are a new class of fluids engineered by dispersing nanometer-size structures (particles, fibers, tubes, droplets) in base fluids. The very essence of nanofluids research and development is to enhance fluid macroscopic and megascale properties such as thermal conductivity through manipulating microscopic physics (structures, properties and activities). Therefore, the success of nanofluid technology depends very much on how well we can address issues like effective means of microscale manipulation, interplays among physics at different scales and optimization of microscale physics for the optimal megascale properties. In this work, we take heat-conduction nanofluids as examples to review methodologies available to effectively tackle these key but difficult problems and identify the future research needs as well. The reviewed techniques include nanofluids synthesis through liquid-phase chemical reactions in continuous-flow microfluidic microreactors, scaling-up by the volume averaging and constructal design with the constructal theory. The identified areas of future research contain microfluidic nanofluids, thermal waves and constructal nanofluids.

  8. Three-party authenticated key agreements for optimal communication

    PubMed Central

    Lee, Tian-Fu; Hwang, Tzonelih

    2017-01-01

    Authenticated key agreements enable users to determine session keys, and to securely communicate with others over an insecure channel via the session keys. This study investigates the lower bounds on communications for three-party authenticated key agreements and considers whether or not the sub-keys for generating a session key can be revealed in the channel. Since two clients do not share any common secret key, they require the help of the server to authenticate their identities and exchange confidential and authenticated information over insecure networks. However, if the session key security is based on asymmetric cryptosystems, then revealing the sub-keys cannot compromise the session key. The clients can directly exchange the sub-keys and reduce the transmissions. In addition, authenticated key agreements were developed by using the derived results of the lower bounds on communications. Compared with related approaches, the proposed protocols had fewer transmissions and realized the lower bounds on communications. PMID:28355253

  9. Fundamental study on the size and inter-key spacing of numeric keys for touch screen.

    PubMed

    Harada, H; Katsuura, T; Kikuchi, Y

    1996-12-01

    The purpose of this study was to reveal the optimum size and inter-key spacing of numeric square keys for touch screens. Six male students (22-25 years old) and three female students (21-24 years old) volunteered as subjects for this experiment. Each subject took part in data entry tasks using numeric square keys of touch devices. The sizes of keys were 6, 12, 21, 30 and 39 mm and each the inter-key spacing was 0, 3, 6, 12 and 21 mm. Response times with key sizes of 6 and 12 mm were significantly slower than with key sizes of 21 and 30 mm (p < 0.001). Furthermore, the key size of 6 mm significantly caused more errors than the key sizes of 12, 21, 30 and 39 mm (p < 0.05). The response time with inter-key spacing of 3 mm was significantly faster than with that of 0, 6, 12 and 21 mm (p < 0.001). Inter-key spacing of 0 mm significantly produced more errors than other inter-key spacing. Subjective ratings for inter-key spacing of 3, 6 and 12 mm were significantly better than those of 0 and 21 mm (p < 0.05). These results suggested that the optimum size of numeric square keys for touch screens should be more than 21 mm and optimum inter-key spacing should be from 3 to 6 mm. Optimum key size, however, must be selected with regard to the limitation of screen size.

  10. Migrant Education Administrative Guide.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Compensatory Education.

    Relating specifically to the North Carolina migrant education program's administrative responsibilities, this guide is designed to aid administrators in program management, monitoring project activities, project evaluation, self-assessment, determining needs for training and staff development, site-visit preparation, policy development, and…

  11. Champions of Children. Administrators . . .

    ERIC Educational Resources Information Center

    Chaffee, John; Olds, H. Robert

    Today, in an era of taxpayer revolts, lack of clarity in values, and changing family structure, children need advocates in the political arena as well as in the schools. This pamphlet suggests that administrators are in an excellent position to defend the rights of children on all fronts. It focuses on what administrators have done and specific…

  12. The Administrative Power Grab

    ERIC Educational Resources Information Center

    Sorenson, Richard D.

    2007-01-01

    Administrative power for some school teachers can be an aphrodisiac that can be applied negatively, especially when a leader has devastating instinct for the weaknesses of others. A leader's intellect and heart closes shop and ceases to function when drunk on power. In this article, the author describes how the use of administrative power can be…

  13. Traditionalism and Educational Administration.

    ERIC Educational Resources Information Center

    Holmes, Mark

    Administration is defined as the enactment of moral choices influencing subordinates within an organizational setting. It is distinguished from management, which is considered to involve a lower level of discretion. Educational administration is therefore in the moral domain; it involves discretionary, moral choices in a field that is itself moral…

  14. Test Administration Models

    ERIC Educational Resources Information Center

    Becker, Kirk A.; Bergstrom, Betty A.

    2013-01-01

    The need for increased exam security, improved test formats, more flexible scheduling, better measurement, and more efficient administrative processes has caused testing agencies to consider converting the administration of their exams from paper-and-pencil to computer-based testing (CBT). Many decisions must be made in order to provide an optimal…

  15. The Administrative Team.

    ERIC Educational Resources Information Center

    Ohio Association of Elementary School Principals, Westerville.

    Although needs of school districts vary with size, degree of teacher negotiation procedures, and type of community involvement, the administrative team model is presented as an effective, appropriate administrative organization. Based on an assumption that each level of authority in a school district possesses and exercises expertise and unique…

  16. Administrative Theory in Transition.

    ERIC Educational Resources Information Center

    Griffiths, Daniel E.

    This monograph analyzes transition in educational administrative theory. A brief introductory section describes the theoretical movement, the substance and repercussions of Thomas Greenfield's critique of educational administrative theory in 1974, and emerging qualitative approaches. Seven readings, all written by the volume's author, view…

  17. Improving Educational Administrative Decisions.

    ERIC Educational Resources Information Center

    Wolfe, A. E.

    This paper discusses the financial crisis facing public education in the United States today and argues that the most effective response to this crisis is to improve the decision-making skills of educational administrators. Based on a review of the literature on administrative decision-making and organizational change, the author examines several…

  18. Sets, Subsets, and Dichotomous Keys

    ERIC Educational Resources Information Center

    Cole, E. James

    1973-01-01

    Discusses the procedures that should be observed in constructing a dichotomous key. The keying exercise described was used as a laboratory activity in a biology course for elementary education majors, however it could be used in other courses. (JR)

  19. Image encryption using fingerprint as key based on phase retrieval algorithm and public key cryptography

    NASA Astrophysics Data System (ADS)

    Zhao, Tieyu; Ran, Qiwen; Yuan, Lin; Chi, Yingying; Ma, Jing

    2015-09-01

    In this paper, a novel image encryption system with fingerprint used as a secret key is proposed based on the phase retrieval algorithm and RSA public key algorithm. In the system, the encryption keys include the fingerprint and the public key of RSA algorithm, while the decryption keys are the fingerprint and the private key of RSA algorithm. If the users share the fingerprint, then the system will meet the basic agreement of asymmetric cryptography. The system is also applicable for the information authentication. The fingerprint as secret key is used in both the encryption and decryption processes so that the receiver can identify the authenticity of the ciphertext by using the fingerprint in decryption process. Finally, the simulation results show the validity of the encryption scheme and the high robustness against attacks based on the phase retrieval technique.

  20. Key Concepts in Informatics: Algorithm

    ERIC Educational Resources Information Center

    Szlávi, Péter; Zsakó, László

    2014-01-01

    "The system of key concepts contains the most important key concepts related to the development tasks of knowledge areas and their vertical hierarchy as well as the links of basic key concepts of different knowledge areas." (Vass 2011) One of the most important of these concepts is the algorithm. In everyday life, when learning or…

  1. Administrative Utility Analysis: Study Summary.

    ERIC Educational Resources Information Center

    Peat, Marwick, Mitchell and Co., San Juan, Puerto Rico.

    This document summarizes the recommendations made as a result of a study on administrative utility analysis and vocational education programs for Puerto Rico. The major recommendation was that the Area of Vocational and Technical Education (AVTE) in the Puerto Rico Department of Education be restructured at the central organizational level, for…

  2. Research Administrators as Servant Leaders

    ERIC Educational Resources Information Center

    Waite, Joann

    2011-01-01

    Within the sponsored research support offices in departments at research institutions, non-profits, and undergraduate institutions, research administrators are often perceived as servant leaders by their own membership organizations and those who work with them. This perception is influenced by survey results focusing on character. Parolini (2004)…

  3. Securing information using optically generated biometric keys

    NASA Astrophysics Data System (ADS)

    Verma, Gaurav; Sinha, Aloka

    2016-11-01

    In this paper, we present a new technique to obtain biometric keys by using the fingerprint of a person for an optical image encryption system. The key generation scheme uses the fingerprint biometric information in terms of the amplitude mask (AM) and the phase mask (PM) of the reconstructed fingerprint image that is implemented using the digital holographic technique. Statistical tests have been conducted to check the randomness of the fingerprint PM key that enables its usage as an image encryption key. To explore the utility of the generated biometric keys, an optical image encryption system has been further demonstrated based on the phase retrieval algorithm and the double random phase encoding scheme in which keys for the encryption are used as the AM and the PM key. The advantage associated with the proposed scheme is that the biometric keys’ retrieval requires the simultaneous presence of the fingerprint hologram and the correct knowledge of the reconstruction parameters at the decryption stage, which not only verifies the authenticity of the person but also protects the valuable fingerprint biometric features of the keys. Numerical results are carried out to prove the feasibility and the effectiveness of the proposed encryption system.

  4. The LCOGT Supernova Key Project

    NASA Astrophysics Data System (ADS)

    Howell, Dale Andrew; Arcavi, Iair; Hosseinzadeh, Griffin; McCully, Curtis; Valenti, Stefano; Lcogt Supernova Key Project

    2015-01-01

    I present first results from the Las Cumbres Observatory Global Telescope Network (LCOGT) Supernova Key Project. LCOGT is a network of 11 robotic one and two meter telescopes spaced around the globe with imaging and spectroscopic capabilities. The supernova key project is a 3 year program to obtain lightcurves and spectra of at least 450 supernovae. About half are expected to be core-collapse supernovae, and half thermonuclear. We will start light curves and spectroscopy within hours of discovery, and focus on those SNe caught soon after explosion. The goals are fivefold: (1) observe supernovae soon after explosion to search for signs of their progenitors, (2) obtain a large homogeneous sample of supernovae for next generation cosmological studies, (3) obtain a large sample of supernovae for statistical studies comparing groups that are split into different populations, (4) obtain some of the first large samples of the recently discovered classes of rare and exotic explosions, (5) obtain the optical light curves and spectroscopy in support of studies at other wavelengths and using other facilities including UV observations, IR imaging and spectroscopy, host galaxy studies, high resolution spectroscopy, and late-time spectroscopy with large telescopes.

  5. Limitations on quantum key repeaters.

    PubMed

    Bäuml, Stefan; Christandl, Matthias; Horodecki, Karol; Winter, Andreas

    2015-04-23

    A major application of quantum communication is the distribution of entangled particles for use in quantum key distribution. Owing to noise in the communication line, quantum key distribution is, in practice, limited to a distance of a few hundred kilometres, and can only be extended to longer distances by use of a quantum repeater, a device that performs entanglement distillation and quantum teleportation. The existence of noisy entangled states that are undistillable but nevertheless useful for quantum key distribution raises the question of the feasibility of a quantum key repeater, which would work beyond the limits of entanglement distillation, hence possibly tolerating higher noise levels than existing protocols. Here we exhibit fundamental limits on such a device in the form of bounds on the rate at which it may extract secure key. As a consequence, we give examples of states suitable for quantum key distribution but unsuitable for the most general quantum key repeater protocol.

  6. Secure key storage and distribution

    DOEpatents

    Agrawal, Punit

    2015-06-02

    This disclosure describes a distributed, fault-tolerant security system that enables the secure storage and distribution of private keys. In one implementation, the security system includes a plurality of computing resources that independently store private keys provided by publishers and encrypted using a single security system public key. To protect against malicious activity, the security system private key necessary to decrypt the publication private keys is not stored at any of the computing resources. Rather portions, or shares of the security system private key are stored at each of the computing resources within the security system and multiple security systems must communicate and share partial decryptions in order to decrypt the stored private key.

  7. Limitations on quantum key repeaters

    NASA Astrophysics Data System (ADS)

    Bäuml, Stefan; Christandl, Matthias; Horodecki, Karol; Winter, Andreas

    2015-04-01

    A major application of quantum communication is the distribution of entangled particles for use in quantum key distribution. Owing to noise in the communication line, quantum key distribution is, in practice, limited to a distance of a few hundred kilometres, and can only be extended to longer distances by use of a quantum repeater, a device that performs entanglement distillation and quantum teleportation. The existence of noisy entangled states that are undistillable but nevertheless useful for quantum key distribution raises the question of the feasibility of a quantum key repeater, which would work beyond the limits of entanglement distillation, hence possibly tolerating higher noise levels than existing protocols. Here we exhibit fundamental limits on such a device in the form of bounds on the rate at which it may extract secure key. As a consequence, we give examples of states suitable for quantum key distribution but unsuitable for the most general quantum key repeater protocol.

  8. The emotional importance of key: do Beatles songs written in different keys convey different emotional tones?

    PubMed

    Whissel, R; Whissel, C

    2000-12-01

    Lyrics from 155 songs written by the Lennon-McCartney team were scored using the Dictionary of Affect in Language. Resultant scores (pleasantness, activation, and imagery of words) were compared across key signatures using one way analyses of variance. Words from songs written in minor keys were less pleasant and less active than those from songs written in major keys. Words from songs written in the key of F scored extremely low on all three measures. Lyrics from the keys of C, D, and G were relatively active in tone. Results from Dictionary scoring were compared with assignments of character to keys made more than one century ago and with current musicians' opinions.

  9. Drug Education for Administrators

    ERIC Educational Resources Information Center

    Hackett, Peter; McKeon, Thomas L.

    1976-01-01

    The formulation of a drug policy and the implementation of that policy in a firm but fair manner are the responsibility of the school administrator. Authors give serious consideration to this responsibility. (Editor/RK)

  10. Food and Drug Administration

    MedlinePlus

    ... blog post. April 11, 2017 ‘Organs-on-Chips’ Technology: FDA Testing Groundbreaking Science More FDA Voice Blog ... FEAR Act Site Map Nondiscrimination Website Policies U.S. Food and Drug Administration 10903 New Hampshire Avenue Silver ...

  11. Administrative Law Judges

    EPA Pesticide Factsheets

    The Administrative Law Judges conduct hearings and render decisions in proceedings between the EPA and persons, businesses, government entities, and other organizations which are or are alleged to be regulated under environmental laws.

  12. Needed: Nursing Administration Leaders

    ERIC Educational Resources Information Center

    Blair, Eunice M.

    1976-01-01

    A master's program that synthesizes clinical nursing knowledge with management theory and skills is one way to prepare nursing service administrators capable of exerting an influence on today's complex health care system. (Editor)

  13. The Administrator Selection Process

    ERIC Educational Resources Information Center

    Griffin, Michael F.

    1974-01-01

    Proposes that education establish for administrators systematic, rigorous, albeit subjective, selection procedures that recognize the principle of organizational democracy and the public nature of the educational enterprise. (Author/DN)

  14. Confrontation and Administrative Response

    ERIC Educational Resources Information Center

    Auerbach, Arnold J.

    1969-01-01

    Describes some of the sociological and psychological effects of organizational conflict and offers 10 operational principles to guide public administrators of schools and social agencies in meeting the confrontation tactics of activist groups. (JH)

  15. One for the Administrators

    ERIC Educational Resources Information Center

    American School and University, 1978

    1978-01-01

    Earth berms, a heavily insulated roof, and a narrow band of thermal pane windows, save energy at the administrative headquarters of the Anoka Hennepin school district in Coon Rapids, a suburb of Minneapolis, Minnesota. (Author/MLF)

  16. Goldstone (GDSCC) administrative computing

    NASA Technical Reports Server (NTRS)

    Martin, H.

    1981-01-01

    The GDSCC Data Processing Unit provides various administrative computing services for Goldstone. Those activities, including finance, manpower and station utilization, deep-space station scheduling and engineering change order (ECO) control are discussed.

  17. Company Administration Study.

    DTIC Science & Technology

    1974-01-01

    iTRATION CENTER AND FORT BENJAMIN HARRISON FORT BENJAMIN HARRISON. INDIANA 46216 ATZI -XO 16 October 1973 SUBJECT: Letter of Instruction - Company...Mail, files, records management* publications, voting, etc.). ... AnnexA II ATZI -XO 18 October 1973 SUBJECT: Letter of Instruction - Company...administration as follows: A. 2 I * * " " " ’+ " " ’ ’ ’ ’’ ’ , ’" I ATZI -XO 18 October 1973 SUBJECT: Letter of Instruction - Company Administration Study tea

  18. Key points in mastopexy.

    PubMed

    De Benito, Javier; Sánchez, Kyrenia

    2010-12-01

    Breasts represent femininity and any change of shape may affect their appearance. Breast ptosis may be caused by several factors, including significant weight loss, pregnancy, long breastfeeding periods, and involution of the postmenopausal breast tissue. Breast ptosis may be associated with breast hypoplasia; thus, in case of a mastopexy with or without the use of implants being indicated, several considerations have to be taken into account: the wishes of the patient, age of the patient, degree of ptosis, parenchymal volume, covering tissue, quality of the tissue, pocket implant, shape and content of the implant, and resulting scars.

  19. Quantum key distribution with finite resources: Secret key rates via Renyi entropies

    SciTech Connect

    Abruzzo, Silvestre; Kampermann, Hermann; Mertz, Markus; Bruss, Dagmar

    2011-09-15

    A realistic quantum key distribution (QKD) protocol necessarily deals with finite resources, such as the number of signals exchanged by the two parties. We derive a bound on the secret key rate which is expressed as an optimization problem over Renyi entropies. Under the assumption of collective attacks by an eavesdropper, a computable estimate of our bound for the six-state protocol is provided. This bound leads to improved key rates in comparison to previous results.

  20. Liability Implications of Forensics Program Administration.

    ERIC Educational Resources Information Center

    Voight, Philip A.; Ward, Courtney E.

    Forensics program administration raises a number of troubling liability concerns. The potential liability exposure of forensics administrators may vastly exceed the litigation risks that arise as a result of ordinary teaching duties. Potential liability exposure may result from the failure of program directors to act in accordance with college or…

  1. Input from Key Stakeholders in the National Security Technology Incubator

    SciTech Connect

    2008-01-31

    This report documents the input from key stakeholders of the National Security Technology Incubator (NSTI) in developing a new technology incubator and related programs for southern New Mexico. The technology incubator is being developed as part of the National Security Preparedness Project (NSPP), funded by a Department of Energy (DOE)/National Nuclear Security Administration (NNSA) grant. This report includes identification of key stakeholders as well as a description and analysis of their input for the development of an incubator.

  2. An Analysis of Academic Programs Preparing Nursing Administrators.

    ERIC Educational Resources Information Center

    Stepura, Barbara A.; Tilbury, Mary S.

    Key elements of the master's level programs offering majors and/or minors in nursing administration and accredited by the National League for Nursing were assessed. The focus was admission and graduation stipulations and curriculum content. Courses were classified according to content and categorized as either administration, research,…

  3. Key sleep neurologic disorders

    PubMed Central

    St. Louis, Erik K.

    2014-01-01

    Summary Sleep disorders are frequent comorbidities in neurologic patients. This review focuses on clinical aspects and prognosis of 3 neurologic sleep disorders: narcolepsy, restless legs syndrome/Willis-Ekbom disease (RLS/WED), and REM sleep behavior disorder (RBD). Narcolepsy causes pervasive, enduring excessive daytime sleepiness, adversely affecting patients' daily functioning. RLS/WED is characterized by an uncomfortable urge to move the legs before sleep, often evolving toward augmentation and resulting in daylong bothersome symptoms. RBD causes potentially injurious dream enactment behaviors that often signify future evolution of overt synucleinopathy neurodegeneration in as many as 81% of patients. Timely recognition, referral for polysomnography, and longitudinal follow-up of narcolepsy, RLS/WED, and RBD patients are imperatives for neurologists in providing quality comprehensive patient care. PMID:24605270

  4. Automated secured cost effective key refreshing technique to enhance WiMAX privacy key management

    NASA Astrophysics Data System (ADS)

    Sridevi, B.; Sivaranjani, S.; Rajaram, S.

    2013-01-01

    In all walks of life the way of communication is transformed by the rapid growth of wireless communication and its pervasive use. A wireless network which is fixed and richer in bandwidth is specified as IEEE 802.16, promoted and launched by an industrial forum is termed as Worldwide Interoperability for Microwave Access (WiMAX). This technology enables seamless delivery of wireless broadband service for fixed and/or mobile users. The obscurity is the long delay which occurs during the handoff management in every network. Mobile WiMAX employs an authenticated key management protocol as a part of handoff management in which the Base Station (BS) controls the distribution of keying material to the Mobile Station (MS). The protocol employed is Privacy Key Management Version 2- Extensible Authentication Protocol (PKMV2-EAP) which is responsible for the normal and periodical authorization of MSs, reauthorization as well as key refreshing. Authorization key (AK) and Traffic Encryption key (TEK) plays a vital role in key exchange. When the lifetime of key expires, MS has to request for a new key to BS which in turn leads to repetition of authorization, authentication as well as key exchange. To avoid service interruption during reauthorization , two active keys are transmitted at the same time by BS to MS. The consequences of existing work are hefty amount of bandwidth utilization, time consumption and large storage. It is also endured by Man in the Middle attack and Impersonation due to lack of security in key exchange. This paper designs an automatic mutual refreshing of keys to minimize bandwidth utilization, key storage and time consumption by proposing Previous key and Iteration based Key Refreshing Function (PKIBKRF). By integrating PKIBKRF in key generation, the simulation results indicate that 21.8% of the bandwidth and storage of keys are reduced and PKMV2 mutual authentication time is reduced by 66.67%. The proposed work is simulated with Qualnet model and

  5. Word Processing: The Air Force Administrators’ Handbook

    DTIC Science & Technology

    1979-05-01

    LEYEL > WORD PROCESSING ERRORCOP Qis 4 pL THE? ~ AIR FORCE ADMINISTRATOR$.! ’--s..HANDBOOK 400 Zi LUPRED F~ Fiir [rLT The views and opinions...INSTRUCTIONSBEFORE COMPLETING FORM I. REPORT NUMBER .O.Vk Er.;. NO. R CIPIENT’S CATALOG NUMBER 4. TITLE (and Subtitle) S. ’TYPE OF REPORT & PERIOD COVERED WORD ...Accession No. ADB 040882 L 19. KEY WORDS (Continue on reverse aide it necessary and identify by block number) Administration / / Administrative Systems

  6. Quantum entanglement assisted key distribution

    NASA Astrophysics Data System (ADS)

    Tang, Ke; Ji, Ping; Zhang, Xiaowen

    2007-04-01

    Quantum correlations or entanglement is a basic ingredient for many applications of quantum information theory.One important application using quantum entanglement exploits the correlation nature of entangled photon states is quantum key distribution, which is proven unbreakable in principle and provides the highest possible security that is impossible in classical information theory. However, generating entangled photon pairs is not a simple task -- only approximately one out of a million pump photons decay into a signal and idler photon pair. This low rate of entangled photon pairs is further reduced by the overhead required in order for the rectification of the inevitable errors due to channel imperfections or caused by potential eavesdroppers. As a consequence, quantum key distribution suffers from a low bit rate, which is in the order of hundreds to thousands bits per second or below. On the other hand, the classical public key distribution does not impose a tight limit on the transmission rate. However, it is subject to the risks of eavesdroppers sitting in the middle of the insecure channel. In this paper, we propose a hybrid key distribution method which uses public key distribution method to generate a raw key, and then uses entanglement assisted communication to modify the raw key by inserting a number of quantum bits in the raw key. Building upon the foundation of the unconditional security of quantum key distribution, we use the privacy amplification to make the affection of inserted bits expand to a whole key. Our quantum entanglement assisted key distribution scheme greatly improves the efficiency of key distribution while without compromising the level of security achievable by quantum cryptography.

  7. Effects of intermittent versus continuous parathyroid hormone administration on condylar chondrocyte proliferation and differentiation

    SciTech Connect

    Liu, Qi; Wan, Qilong; Yang, Rongtao; Zhou, Haihua; Li, Zubing

    2012-07-20

    Highlights: Black-Right-Pointing-Pointer Different PTH administration exerts different effects on condylar chondrocyte. Black-Right-Pointing-Pointer Intermittent PTH administration suppresses condylar chondrocyte proliferation. Black-Right-Pointing-Pointer Continuous PTH administration maintains condylar chondrocyte proliferating. Black-Right-Pointing-Pointer Intermittent PTH administration enhances condylar chondrocyte differentiation. -- Abstract: Endochondral ossification is a complex process involving chondrogenesis and osteogenesis regulated by many hormones and growth factors. Parathyroid hormone (PTH), one of the key hormones regulating bone metabolism, promotes osteoblast differentiation and osteogenesis by intermittent administration, whereas continuous PTH administration inhibits bone formation. However, the effects of PTH on chondrocyte proliferation and differentiation are still unclear. In this study, intermittent PTH administration presented enhanced effects on condylar chondrocyte differentiation and bone formation, as demonstrated by increased mineral nodule formation and alkaline phosphatase (ALP) activity, up-regulated runt-related transcription factor 2 (RUNX2), ALP, collagen type X (COL10a1), collagen type I (COL1a1), osteocalcin (OCN), bone sialoprotein (BSP), bone morphogenetic protein 2 (BMP2) and osterix (OSX) mRNA and/or protein expression. On the contrary, continuous PTH administration promoted condylar chondrocyte proliferation and suppressed its differentiation, as demonstrated by up-regulated collagen type II (COL2a1) mRNA expression, reduced mineral nodule formation and down-regulated expression of the mRNAs and/or proteins mentioned above. Our data suggest that PTH can regulate condylar chondrocyte proliferation and differentiation, depending on the type of PTH administration. These results provide new insight into the effects of PTH on condylar chondrocytes and new evidence for using local PTH administration to cure mandibular

  8. Computer hardware fault administration

    DOEpatents

    Archer, Charles J.; Megerian, Mark G.; Ratterman, Joseph D.; Smith, Brian E.

    2010-09-14

    Computer hardware fault administration carried out in a parallel computer, where the parallel computer includes a plurality of compute nodes. The compute nodes are coupled for data communications by at least two independent data communications networks, where each data communications network includes data communications links connected to the compute nodes. Typical embodiments carry out hardware fault administration by identifying a location of a defective link in the first data communications network of the parallel computer and routing communications data around the defective link through the second data communications network of the parallel computer.

  9. Keys to the Natural World.

    ERIC Educational Resources Information Center

    Misiti, Frank L., Jr.

    1996-01-01

    Presents a lesson that uses the learning cycle to introduce the concept of classification and the use of dichotomous keys to identify plants and animals. Encourages students to become better observers and helps them gain confidence and experience in using simple classification keys. (JRH)

  10. Decreased exposure to sunitinib due to concomitant administration of ifosfamide: results of a phase I and pharmacokinetic study on the combination of sunitinib and ifosfamide in patients with advanced solid malignancies

    PubMed Central

    Hamberg, P; Steeghs, N; Loos, W J; van de Biessen, D; den Hollander, M; Tascilar, M; Verweij, J; Gelderblom, H; Sleijfer, S

    2010-01-01

    Background: This study aimed to define the maximally tolerated dose (MTD) of sunitinib combined with two different infusion schedules of ifosfamide. Methods: Patients with advanced solid tumours, good performance score, good organ function, and no standard therapy available were eligible. Continuous once daily sunitinib, in escalating doses per cohort, was combined with ifosfamide, 9 g m−2 for 3 days or 6 g m−2 for 5 days, administered every 3 weeks. Pharmacokinetic (PK) and pharmacodynamic (PD) assessments were performed. Results: With growth-factor support, the MTD of sunitinib combined with either ifosfamide schedule was 12.5 mg in 32 patients enrolled. Neutropenia-related adverse events were dose-limiting toxicities. Sunitinib did not affect ifosfamide PK. Ifosfamide significantly decreased exposure to sunitinib and increased exposure to its metabolite, SU12662. No consistent changes in PD parameters were observed. Conclusion: With growth-factor support, the MTD of sunitinib with both ifosfamide schedules was 12.5 mg. Ifosfamide produced decreased sunitinib blood levels because of CYP3A induction. As PK interactions cannot explain the relatively low sunitinib doses that can be combined with ifosfamide, synergy in toxicity is likely. Whether this also holds true for anti-tumour activity needs to be further explored. PMID:20485286

  11. 75 FR 62766 - First Antidumping Duty Administrative Review of Sodium Hexametaphosphate From the People's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... International Trade Administration First Antidumping Duty Administrative Review of Sodium Hexametaphosphate From... (``Department'') published the Preliminary Results of the first administrative review of sodium... February 28, 2009. See First Administrative Review of Sodium Hexametaphosphate From the People's...

  12. Supporting Student Research at the Administrative Level.

    ERIC Educational Resources Information Center

    Gibson, William A.

    1993-01-01

    This article examines administrative support and its role in developing and sustaining student research activities within schools of dentistry. Discussion focuses on how administrative support can be effective in the areas of mentor selection, funding, managing educational quality, assistance in presenting research results, and providing rewards.…

  13. Voices from the Field: Central Office Administrators

    ERIC Educational Resources Information Center

    Dickson, Ken

    2015-01-01

    School systems' central office administrators sometimes take paths that seem easiest, even when it is clear the paths will not lead to sustained positive results that are needed--particularly in terms of twice-exceptional (2e) students. To appropriately address the needs of 2e learners, we must ensure that central office administrative services…

  14. Administrative Utility Analysis: Appendices.

    ERIC Educational Resources Information Center

    Peat, Marwick, Mitchell and Co., San Juan, Puerto Rico.

    Appendixes to a study on administrative utility analysis and vocational education programs for the Area of Vocational and Technical Education (AVTE) in the Puerto Rico Department of Education contain the planning and budgeting system elements, position descriptions, and information on the growth of vocational education in Puerto Rico. The elements…

  15. Administrative Sides of Librarying.

    ERIC Educational Resources Information Center

    Lott, Carolyn

    2003-01-01

    Discusses how the author used administrative skills learned as a school library media specialist to meet the demands of a university department chair. Topics include the influence of decisions that are made; budgeting; evaluation concerns and responsibilities; determining guidelines and goals; political concerns; and the flow of information. (LRW)

  16. The Administration of Admissions

    ERIC Educational Resources Information Center

    Campbell, Clifford C.

    1978-01-01

    Among all the tasks of the admissions officer in developing a successful marketing program, the hardest may be that of convincing other college administrators of the importance of admissions to the institution's survival. Discussed are long-range planning, budgeting, staff selection and training, and implementing a plan. (Author/LBH)

  17. Administrators Confront Student "Sexting"

    ERIC Educational Resources Information Center

    Manzo, Kathleen Kennedy

    2009-01-01

    Cellphone-savvy students have created instructional and disciplinary challenges for educators for years. But the recent emergence of "sexting" by adolescents over their mobile phones caught many school administrators off guard, and the practice is prompting efforts around the country to craft policy responses. Students' sharing of nude or…

  18. IVA: Improving Vocational Administration.

    ERIC Educational Resources Information Center

    EPD Consortium D, Richardson, TX.

    These six instructional units are intended to provide instructors of vocational education administration with a systematic package of materials for their programs of preservice and/or inservice instruction and to provide materials which could be reproduced for learner use. These units cover the following subject matter: (1) federal legislation…

  19. Migrant Education Administrative Handbook.

    ERIC Educational Resources Information Center

    Louisiana State Dept. of Education, Baton Rouge. Bureau of Migrant Education.

    Intended to provide information pertaining to the administration of migrant education projects in Louisiana, the handbook is divided into two sections: basic guidelines for program operations and support services--nursing. Section I covers the Federal and State migrant program, local migrant projects, project personnel and staff development, and…

  20. Educational Administration's Weber.

    ERIC Educational Resources Information Center

    Gronn, Peter

    1994-01-01

    Discusses Max Weber's importance in Greenfield's work, particularly in Greenfield and Ribbins'"Greenfield on Educational Administration" (1993). In concentrating on human actors' subjective understanding, Greenfield was a faithful Weberian. However, he deviated from Weber by disavowing structural explanations of social and organizational…

  1. The Administrative Internship.

    ERIC Educational Resources Information Center

    Adkison, Judith A., Ed.; Warren, Andrea, Ed.

    This monograph was developed as part of the project known as Internships, Certification, Equity-Leadership, and Support (ICES). The Kansas project successfully field-tested a model for mobilizing statewide resources to prepare women for administrative careers and to place them in appropriate positions. The crucial component of the training program…

  2. Standards and Administration.

    ERIC Educational Resources Information Center

    Gross, S. P.

    1978-01-01

    Presents a literature review of water quality standards and administration, covering publications of 1976-77. Consideration is given to municipal facilities, National Pollutant Discharge Elimination Systems, regional and international water quality management, and effluent standards. A list of 99 references is also presented. (HM)

  3. Championing the Latino Administrator

    ERIC Educational Resources Information Center

    Garcia, Carlos A.

    2011-01-01

    When the author worked as a vice principal at a K-8 school in Watsonville, California, a school predominantly filled with migrant workers' children, he felt a lack of support as a Latino as he began moving up into school administration. He also continued to see what he had seen as a teacher--which was how underserved minority students were. These…

  4. Redis database administration tool

    SciTech Connect

    Martinez, J. J.

    2013-02-13

    MyRedis is a product of the Lorenz subproject under the ASC Scirntific Data Management effort. MyRedis is a web based utility designed to allow easy administration of instances of Redis databases. It can be usedd to view and manipulate data as well as run commands directly against a variety of different Redis hosts.

  5. Administrative Uses of Microcomputers.

    ERIC Educational Resources Information Center

    Crawford, Chase

    1987-01-01

    This paper examines the administrative uses of the microcomputer, stating that high performance educational managers are likely to have microcomputers in their organizations. Four situations that would justify the use of a computer are: (1) when massive amounts of data are processed through well-defined operations; (2) when data processing is…

  6. Educator Effectiveness Administrative Manual

    ERIC Educational Resources Information Center

    Pennsylvania Department of Education, 2014

    2014-01-01

    The goal of this manual is to provide guidance in the evaluation of educators, highlight critical components of effectiveness training, and offer opportunities for professional growth. The term "educator" includes teachers, all professional and temporary professional employees, education specialists, and school administrators/principals.…

  7. Discretionary Grants Administration Manual.

    ERIC Educational Resources Information Center

    Office of Human Development Services (DHHS), Washington, DC.

    This manual sets forth applicable administrative policies and procedures to recipients of discretionary project grants or cooperative agreements awarded by program offices in the Office of Human Development Services (HDS). It is intended to serve as a basic reference for project directors and business officers of recipient organizations who are…

  8. [Rural School Administrator's Resources.

    ERIC Educational Resources Information Center

    AEL, Inc., Charleston, WV.

    This packet contains resources on five topics relevant to rural school administrators. "Assessing Parent Involvement: A Checklist for Rural Schools": discusses educator beliefs that support successful parent engagement programs, challenges and advantages of rural schools attempting to involve parents and community, and aspects of…

  9. Standards for Administrators.

    ERIC Educational Resources Information Center

    Lashway, Larry

    1998-01-01

    This newsletter reviews five reports that address the implications of standards for administrators. These texts include "Designing and Implementing Standards-Based Accountability System" (Education Commission of the States), which describes some of the policy implications of standards-driven accountability; "Why Principals Fail: Are National…

  10. Finite key analysis for symmetric attacks in quantum key distribution

    SciTech Connect

    Meyer, Tim; Kampermann, Hermann; Kleinmann, Matthias; Bruss, Dagmar

    2006-10-15

    We introduce a constructive method to calculate the achievable secret key rate for a generic class of quantum key distribution protocols, when only a finite number n of signals is given. Our approach is applicable to all scenarios in which the quantum state shared by Alice and Bob is known. In particular, we consider the six state protocol with symmetric eavesdropping attacks, and show that for a small number of signals, i.e., below n{approx}10{sup 4}, the finite key rate differs significantly from the asymptotic value for n{yields}{infinity}. However, for larger n, a good approximation of the asymptotic value is found. We also study secret key rates for protocols using higher-dimensional quantum systems.

  11. Extended key-factor/key-stage analysis for longitudinal data.

    PubMed

    Yamamura, Kohji

    2012-01-01

    Key-factor/key-stage analysis was originally a descriptive approach to analyze life tables. However, this method can be extended to analyze longitudinal data in pharmaceutical experiments. By dividing the variance into components, the extended key-factor/key-stage analysis indicates which factor is influential, and through which stage the factor generates its influence in determining the outcome of treatments. Such knowledge helps us in constructing a class of nonlinear longitudinal models that can be interpretable than linear models. Example SAS programs and R programs are provided for the calculation. Supplemental materials are available for this article. Go to the publisher's online edition of Journal of Biopharmaceutical Statistics to view the supplemental files.

  12. Advanced Contract Administration. First Week

    DTIC Science & Technology

    1988-04-14

    administration. Keywords: Contracting/administrative contracting officer relations Financial management; Production management , Quality assurance; Subcontracting; Claims; Government property; Ethics data sources and modifications.

  13. Key characteristics of specular stereo.

    PubMed

    Muryy, Alexander A; Fleming, Roland W; Welchman, Andrew E

    2014-12-24

    Because specular reflection is view-dependent, shiny surfaces behave radically differently from matte, textured surfaces when viewed with two eyes. As a result, specular reflections pose substantial problems for binocular stereopsis. Here we use a combination of computer graphics and geometrical analysis to characterize the key respects in which specular stereo differs from standard stereo, to identify how and why the human visual system fails to reconstruct depths correctly from specular reflections. We describe rendering of stereoscopic images of specular surfaces in which the disparity information can be varied parametrically and independently of monocular appearance. Using the generated surfaces and images, we explain how stereo correspondence can be established with known and unknown surface geometry. We show that even with known geometry, stereo matching for specular surfaces is nontrivial because points in one eye may have zero, one, or multiple matches in the other eye. Matching features typically yield skew (nonintersecting) rays, leading to substantial ortho-epipolar components to the disparities, which makes deriving depth values from matches nontrivial. We suggest that the human visual system may base its depth estimates solely on the epipolar components of disparities while treating the ortho-epipolar components as a measure of the underlying reliability of the disparity signals. Reconstructing virtual surfaces according to these principles reveals that they are piece-wise smooth with very large discontinuities close to inflection points on the physical surface. Together, these distinctive characteristics lead to cues that the visual system could use to diagnose specular reflections from binocular information.

  14. Secure Key from Bound Entanglement

    NASA Astrophysics Data System (ADS)

    Horodecki, Karol; Horodecki, Michał; Horodecki, Paweł; Oppenheim, Jonathan

    2005-04-01

    We characterize the set of shared quantum states which contain a cryptographically private key. This allows us to recast the theory of privacy as a paradigm closely related to that used in entanglement manipulation. It is shown that one can distill an arbitrarily secure key from bound entangled states. There are also states that have less distillable private keys than the entanglement cost of the state. In general, the amount of distillable key is bounded from above by the relative entropy of entanglement. Relationships between distillability and distinguishability are found for a class of states which have Bell states correlated to separable hiding states. We also describe a technique for finding states exhibiting irreversibility in entanglement distillation.

  15. CSB's Key Management Challenges - 2014

    EPA Pesticide Factsheets

    The Office of Inspector General is beginning work to update the fiscal year 2014 list of areas we consider to be the key management challenges confronting the U.S. Chemical Safety and Hazard Investigation Board.

  16. Key Statistics for Thyroid Cancer

    MedlinePlus

    ... and Treatment? Thyroid Cancer About Thyroid Cancer Key Statistics for Thyroid Cancer How common is thyroid cancer? ... remains very low compared with most other cancers. Statistics on survival rates for thyroid cancer are discussed ...

  17. Identification of the Key Fields and Their Key Technical Points of Oncology by Patent Analysis

    PubMed Central

    Zhang, Ting; Chen, Juan; Jia, Xiaofeng

    2015-01-01

    Background This paper aims to identify the key fields and their key technical points of oncology by patent analysis. Methodology/Principal Findings Patents of oncology applied from 2006 to 2012 were searched in the Thomson Innovation database. The key fields and their key technical points were determined by analyzing the Derwent Classification (DC) and the International Patent Classification (IPC), respectively. Patent applications in the top ten DC occupied 80% of all the patent applications of oncology, which were the ten fields of oncology to be analyzed. The number of patent applications in these ten fields of oncology was standardized based on patent applications of oncology from 2006 to 2012. For each field, standardization was conducted separately for each of the seven years (2006–2012) and the mean of the seven standardized values was calculated to reflect the relative amount of patent applications in that field; meanwhile, regression analysis using time (year) and the standardized values of patent applications in seven years (2006–2012) was conducted so as to evaluate the trend of patent applications in each field. Two-dimensional quadrant analysis, together with the professional knowledge of oncology, was taken into consideration in determining the key fields of oncology. The fields located in the quadrant with high relative amount or increasing trend of patent applications are identified as key ones. By using the same method, the key technical points in each key field were identified. Altogether 116,820 patents of oncology applied from 2006 to 2012 were retrieved, and four key fields with twenty-nine key technical points were identified, including “natural products and polymers” with nine key technical points, “fermentation industry” with twelve ones, “electrical medical equipment” with four ones, and “diagnosis, surgery” with four ones. Conclusions/Significance The results of this study could provide guidance on the development

  18. Finite-key security analysis for multilevel quantum key distribution

    NASA Astrophysics Data System (ADS)

    Brádler, Kamil; Mirhosseini, Mohammad; Fickler, Robert; Broadbent, Anne; Boyd, Robert

    2016-07-01

    We present a detailed security analysis of a d-dimensional quantum key distribution protocol based on two and three mutually unbiased bases (MUBs) both in an asymptotic and finite-key-length scenario. The finite secret key rates (in bits per detected photon) are calculated as a function of the length of the sifted key by (i) generalizing the uncertainly relation-based insight from BB84 to any d-level 2-MUB QKD protocol and (ii) by adopting recent advances in the second-order asymptotics for finite block length quantum coding (for both d-level 2- and 3-MUB QKD protocols). Since the finite and asymptotic secret key rates increase with d and the number of MUBs (together with the tolerable threshold) such QKD schemes could in principle offer an important advantage over BB84. We discuss the possibility of an experimental realization of the 3-MUB QKD protocol with the orbital angular momentum degrees of freedom of photons.

  19. Complying with Occupational Safety and Health Administration regulations: a guide for compounding pharmacists.

    PubMed

    Mixon, Bill; Nain, John

    2013-01-01

    In the compounding pharmacy, compliance with Occupational Safety and Health Administration regulations is essential to protect employees and customers from exposure to hazardous substances and a dangerous environment, to avert heavy fines and penalties levied for noncompliance, and to fulfill the moral obligation of pharmacists to do no harm. Without adequate vigilance, compounders are vulnerable to lapses in adherence to Occupational Safety and Health Administration requirements, the results of which can be dire in a climate of increased scrutiny about the safety and integrity of pharmaceutical compounding. Proactively addressing necessary compliance with essential safety regulations can only benefit compounders and their staff and clients, and guidance from an expert in Occupational Safety and Health Administration requirements can be a key factor in accomplishing that goal.

  20. Principles of visual key construction―with a visual identification key to the Fagaceae of the southeastern United States

    PubMed Central

    Kirchoff, Bruce K.; Leggett, Roxanne; Her, Va; Moua, Chue; Morrison, Jessica; Poole, Chamika

    2011-01-01

    Background and aims Advances in digital imaging have made possible the creation of completely visual keys. By a visual key we mean a key based primarily on images, and that contains a minimal amount of text. Characters in visual keys are visually, not verbally defined. In this paper we create the first primarily visual key to a group of taxa, in this case the Fagaceae of the southeastern USA. We also modify our recently published set of best practices for image use in illustrated keys to make them applicable to visual keys. Methodology Photographs of the Fagaceae were obtained from internet and herbarium databases or were taken specifically for this project. The images were printed and then sorted into hierarchical groups. These hierarchical groups of images were used to create the ‘couplets’ in the key. A reciprocal process of key creation and testing was used to produce the final keys. Principal results Four keys were created, one for each of the parts—leaves, buds, fruits and bark. Species description pages consisting of multiple images were also created for each of the species in the key. Creation and testing of the key resulted in a modified list of best practices for image use visual keys. Conclusions The inclusion of images into paper and electronic keys has greatly increased their ease of use. However, virtually all of these keys are still based upon verbally defined, atomistic characters. The creation of primarily visual keys allows us to overcome the well-known limitations of linguistic-based characters and create keys that are much easier to use, especially for botanical novices. PMID:22476476

  1. Key issues in transplant tourism.

    PubMed

    Akoh, Jacob A

    2012-02-24

    Access to organ transplantation depends on national circumstances, and is partly determined by the cost of health care, availability of transplant services, the level of technical capacity and the availability of organs. Commercial transplantation is estimated to account for 5%-10% (3500-7000) of kidney transplants performed annually throughout the world. This review is to determine the state and outcome of renal transplantation associated with transplant tourism (TT) and the key challenges with such transplantation. The stakeholders of commercial transplantation include: patients on the waiting lists in developed countries or not on any list in developing countries; dialysis funding bodies; middlemen, hosting transplant centres; organ-exporting countries; and organ vendors. TT and commercial kidney transplants are associated with a high incidence of surgical complications, acute rejection and invasive infection which cause major morbidity and mortality. There are ethical and medical concerns regarding the management of recipients of organs from vendors. The growing demand for transplantation, the perceived failure of altruistic donation in providing enough organs has led to calls for a legalised market in organ procurement or regulated trial in incentives for donation. Developing transplant services worldwide has many benefits - improving results of transplantation as they would be performed legally, increasing the donor pool and making TT unnecessary. Meanwhile there is a need to re-examine intrinsic attitudes to TT bearing in mind the cultural and economic realities of globalisation. Perhaps the World Health Organization in conjunction with The Transplantation Society would set up a working party of stakeholders to study this matter in greater detail and make recommendations.

  2. Key issues in transplant tourism

    PubMed Central

    Akoh, Jacob A

    2012-01-01

    Access to organ transplantation depends on national circumstances, and is partly determined by the cost of health care, availability of transplant services, the level of technical capacity and the availability of organs. Commercial transplantation is estimated to account for 5%-10% (3500-7000) of kidney transplants performed annually throughout the world. This review is to determine the state and outcome of renal transplantation associated with transplant tourism (TT) and the key challenges with such transplantation. The stakeholders of commercial transplantation include: patients on the waiting lists in developed countries or not on any list in developing countries; dialysis funding bodies; middlemen, hosting transplant centres; organ-exporting countries; and organ vendors. TT and commercial kidney transplants are associated with a high incidence of surgical complications, acute rejection and invasive infection which cause major morbidity and mortality. There are ethical and medical concerns regarding the management of recipients of organs from vendors. The growing demand for transplantation, the perceived failure of altruistic donation in providing enough organs has led to calls for a legalised market in organ procurement or regulated trial in incentives for donation. Developing transplant services worldwide has many benefits - improving results of transplantation as they would be performed legally, increasing the donor pool and making TT unnecessary. Meanwhile there is a need to re-examine intrinsic attitudes to TT bearing in mind the cultural and economic realities of globalisation. Perhaps the World Health Organization in conjunction with The Transplantation Society would set up a working party of stakeholders to study this matter in greater detail and make recommendations. PMID:24175191

  3. Entropy driven key-lock assembly.

    PubMed

    Odriozola, G; Jiménez-Angeles, F; Lozada-Cassou, M

    2008-09-21

    The effective interaction between a sphere with an open cavity (lock) and a spherical macroparticle (key), both immersed in a hard sphere fluid, is studied by means of Monte Carlo simulations. As a result, a two-dimensional map of the key-lock effective interaction potential is constructed, which leads to the proposal of a self-assembling mechanism: There exists trajectories through which the key-lock pair could assemble avoiding trespassing potential barriers. Hence, solely the entropic contribution can induce their self-assembling even in the absence of attractive forces. This study points out the solvent contribution within the underlying mechanisms of substrate-protein assemblydisassembly processes, which are important steps of the enzyme catalysis and protein mediated transport.

  4. An absolute measure for a key currency

    NASA Astrophysics Data System (ADS)

    Oya, Shunsuke; Aihara, Kazuyuki; Hirata, Yoshito

    It is generally considered that the US dollar and the euro are the key currencies in the world and in Europe, respectively. However, there is no absolute general measure for a key currency. Here, we investigate the 24-hour periodicity of foreign exchange markets using a recurrence plot, and define an absolute measure for a key currency based on the strength of the periodicity. Moreover, we analyze the time evolution of this measure. The results show that the credibility of the US dollar has not decreased significantly since the Lehman shock, when the Lehman Brothers bankrupted and influenced the economic markets, and has increased even relatively better than that of the euro and that of the Japanese yen.

  5. Key China Energy Statistics 2012

    SciTech Connect

    Levine, Mark; Fridley, David; Lu, Hongyou; Fino-Chen, Cecilia

    2012-05-01

    The China Energy Group at Lawrence Berkeley National Laboratory (LBNL) was established in 1988. Over the years the Group has gained recognition as an authoritative source of China energy statistics through the publication of its China Energy Databook (CED). The Group has published seven editions to date of the CED (http://china.lbl.gov/research/chinaenergy-databook). This handbook summarizes key statistics from the CED and is expressly modeled on the International Energy Agency’s “Key World Energy Statistics” series of publications. The handbook contains timely, clearly-presented data on the supply, transformation, and consumption of all major energy sources.

  6. Key China Energy Statistics 2011

    SciTech Connect

    Levine, Mark; Fridley, David; Lu, Hongyou; Fino-Chen, Cecilia

    2012-01-15

    The China Energy Group at Lawrence Berkeley National Laboratory (LBNL) was established in 1988. Over the years the Group has gained recognition as an authoritative source of China energy statistics through the publication of its China Energy Databook (CED). In 2008 the Group published the Seventh Edition of the CED (http://china.lbl.gov/research/chinaenergy-databook). This handbook summarizes key statistics from the CED and is expressly modeled on the International Energy Agency’s “Key World Energy Statistics” series of publications. The handbook contains timely, clearly-presented data on the supply, transformation, and consumption of all major energy sources.

  7. Ten Keys to the Portal

    ERIC Educational Resources Information Center

    Schaffhauser, Dian

    2011-01-01

    Successful web portals help users stay informed, in touch, and up to speed. They are also a telling window into the efficiency of one's institution. To develop a cutting-edge portal takes planning, communication, and research. In this article, the author presents and discusses 10 keys to portal success: (1) make critical info visible; (2) make the…

  8. Seven Keys to Successful Study.

    ERIC Educational Resources Information Center

    Edwards, Peter

    Written for secondary, technical, and technical and further education (TAFE) students, this book aims to make learning easier and more enjoyable by showing students how to use a series of basic study skills called "keys." The book offers an explanation, examples, graphic illustrations, and activities for each skill. Chapters include: (1)…

  9. Key for Trees of Iowa.

    ERIC Educational Resources Information Center

    Coder, Kim D.; Wray, Paul H.

    This key is designed to help identify the most common trees found in Iowa. It is based on vegetative characteristics such as leaves, fruits, and bark and is illustrated with black and white line drawings. Since vegetative characteristics vary due to climate, age, soil fertility, and other conditions, the numerical sizes listed, such as length and…

  10. Analysis of Key Education Instrumentation.

    ERIC Educational Resources Information Center

    Penfield, Douglas A.; And Others

    The Key Assessment System, consisting of test instruments which measure psychological functioning, work related competencies, and attitudinal and motivational characteristics, is described. The system is a vocational assessment battery designed to differentiate levels of psychophysical capabilities in a nondiscriminatory manner. It provides a…

  11. Key Skills and Competencies. Symposium.

    ERIC Educational Resources Information Center

    2002

    This document contains three papers on key skills and competencies and human resource development (HRD). "Career Related Competencies" (Marinka A.C.T. Kuijpers) reports findings from surveys completed by Dutch employees who identified these issues: self-reflection is more important than career control; age and gender influence attitude…

  12. Key Issues in Hadronic Physics

    SciTech Connect

    Simon Capstick; et. Al.

    2000-12-01

    A group of fifty physicists met in Duck, NC, Nov. 6-9 to discuss the current status and future goals of hadronic physics. The main purpose of the meeting was to define the field by identifying its key issues, challenges, and opportunities. The conclusions, incorporating considerable input from the community at large, are presented in this white paper.

  13. Open Archives: A Key Convergence.

    ERIC Educational Resources Information Center

    Tennant, Roy

    2000-01-01

    Discusses interoperability as a key challenge to digital libraries and describes efforts of the Open Archives initiative (formerly Universal Preprint Service initiative) to develop an open architecture that supports simultaneous searching and retrieval of papers from disparate archives. Highlights include scientific information and journal…

  14. Key factors determining the efficacy of gene therapy for continuous DOPA delivery in the Parkinsonian brain.

    PubMed

    Cederfjäll, Erik; Sahin, Gurdal; Kirik, Deniz

    2012-11-01

    L-DOPA is currently the standard treatment for alleviating the motor symptoms in Parkinson's disease. The therapeutic efficacy, however, diminishes as the disease progresses. It has been suggested that the beneficial effect of L-DOPA could be reestablished by changing the mode of administration. Indeed, continuous delivery of l-DOPA has been shown to be an effective way to circumvent many of the side effects seen with traditional oral administration, which results in an intermittent supply of the dopamine precursor to the brain. However, all currently tested continuous dopaminergic stimulation approaches rely on peripheral administration. This is not ideal since it gives rise to off target effects and is difficult to maintain long-term. Thus, there is an unmet need for an effective continuous administration method with an acceptable side effect profile. Viral-mediated gene therapy is a promising alternative paradigm that can meet this demand. Encouraging preclinical studies in animal models of Parkinson's disease showed therapeutic efficacy after expression of the genes encoding the enzymes required for biosynthesis of dopamine. Although the first phase I clinical trials using these approaches have been conducted, clear positive data in placebo controlled efficacy studies is still lacking. We are now at a critical junction and need to carefully review the preclinical data from the clinical translation perspective and identify the key factors that will determine the potential for success in gene therapy for Parkinson's disease.

  15. Key Reconciliation for High Performance Quantum Key Distribution

    PubMed Central

    Martinez-Mateo, Jesus; Elkouss, David; Martin, Vicente

    2013-01-01

    Quantum Key Distribution is carving its place among the tools used to secure communications. While a difficult technology, it enjoys benefits that set it apart from the rest, the most prominent is its provable security based on the laws of physics. QKD requires not only the mastering of signals at the quantum level, but also a classical processing to extract a secret-key from them. This postprocessing has been customarily studied in terms of the efficiency, a figure of merit that offers a biased view of the performance of real devices. Here we argue that it is the throughput the significant magnitude in practical QKD, specially in the case of high speed devices, where the differences are more marked, and give some examples contrasting the usual postprocessing schemes with new ones from modern coding theory. A good understanding of its implications is very important for the design of modern QKD devices. PMID:23546440

  16. Public key infrastructure for DOE security research

    SciTech Connect

    Aiken, R.; Foster, I.; Johnston, W.E.

    1997-06-01

    This document summarizes the Department of Energy`s Second Joint Energy Research/Defence Programs Security Research Workshop. The workshop, built on the results of the first Joint Workshop which reviewed security requirements represented in a range of mission-critical ER and DP applications, discussed commonalties and differences in ER/DP requirements and approaches, and identified an integrated common set of security research priorities. One significant conclusion of the first workshop was that progress in a broad spectrum of DOE-relevant security problems and applications could best be addressed through public-key cryptography based systems, and therefore depended upon the existence of a robust, broadly deployed public-key infrastructure. Hence, public-key infrastructure ({open_quotes}PKI{close_quotes}) was adopted as a primary focus for the second workshop. The Second Joint Workshop covered a range of DOE security research and deployment efforts, as well as summaries of the state of the art in various areas relating to public-key technologies. Key findings were that a broad range of DOE applications can benefit from security architectures and technologies built on a robust, flexible, widely deployed public-key infrastructure; that there exists a collection of specific requirements for missing or undeveloped PKI functionality, together with a preliminary assessment of how these requirements can be met; that, while commercial developments can be expected to provide many relevant security technologies, there are important capabilities that commercial developments will not address, due to the unique scale, performance, diversity, distributed nature, and sensitivity of DOE applications; that DOE should encourage and support research activities intended to increase understanding of security technology requirements, and to develop critical components not forthcoming from other sources in a timely manner.

  17. Administrator Protections in Negotiated Contracts.

    ERIC Educational Resources Information Center

    Pisapia, John Ralph; Sells, Jack D.

    1978-01-01

    Presents specific examples of provisions currently found in administrator-board collective bargaining agreements that protect administrators from the adverse effects of both bilateral decisions made by boards with teachers, and unilateral decisions made by boards concerning principals. (Author)

  18. Administrative Aspects of Human Experimentation.

    ERIC Educational Resources Information Center

    Irvine, George W.

    1992-01-01

    The following administrative aspects of scientific experimentation with human subjects are discussed: the definition of human experimentation; the distinction between experimentation and treatment; investigator responsibility; documentation; the elements and principles of informed consent; and the administrator's role in establishing and…

  19. Administration for Children and Families

    MedlinePlus

    ... Speeches Videos What is the Administration for Children & Families? The Administration for Children and Families (ACF) is ... Visit the Office of Community Services Website The Family Room Blog RSS Feed Building Community, Building Hope: ...

  20. An improved key agreement protocol based on chaos

    NASA Astrophysics Data System (ADS)

    Wang, Xingyuan; Zhao, Jianfeng

    2010-12-01

    Cryptography based on chaos theory has developed fast in the past few years, but most of the researches focus on secret key cryptography. There are few public key encryption algorithms and cryptographic protocols based on chaos, which are also of great importance for network security. We introduce an enhanced key agreement protocol based on Chebyshev chaotic map. Utilizing the semi-group property of Chebyshev polynomials, the proposed key exchange algorithm works like Diffie-Hellman algorithm. The improved protocol overcomes the drawbacks of several previously proposed chaotic key agreement protocols. Both analytical and experimental results show that it is effective and secure.

  1. Improved key-rate bounds for practical decoy-state quantum-key-distribution systems

    NASA Astrophysics Data System (ADS)

    Zhang, Zhen; Zhao, Qi; Razavi, Mohsen; Ma, Xiongfeng

    2017-01-01

    The decoy-state scheme is the most widely implemented quantum-key-distribution protocol in practice. In order to account for the finite-size key effects on the achievable secret key generation rate, a rigorous statistical fluctuation analysis is required. Originally, a heuristic Gaussian-approximation technique was used for this purpose, which, despite its analytical convenience, was not sufficiently rigorous. The fluctuation analysis has recently been made rigorous by using the Chernoff bound. There is a considerable gap, however, between the key-rate bounds obtained from these techniques and that obtained from the Gaussian assumption. Here we develop a tighter bound for the decoy-state method, which yields a smaller failure probability. This improvement results in a higher key rate and increases the maximum distance over which secure key exchange is possible. By optimizing the system parameters, our simulation results show that our method almost closes the gap between the two previously proposed techniques and achieves a performance similar to that of conventional Gaussian approximations.

  2. NOAA administrator reviews agency progress and challenges

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2011-12-01

    The approach of the new year is a traditional time to tally up successes, failures, and the path ahead. Jane Lubchenco, administrator of the U.S. National Oceanic and Atmospheric Administration (NOAA), examined some agency advances and significant challenges during the 7 December Union Agency Lecture at the AGU Fall Meeting, during a press briefing, and in an interview with Eos. Lubchenco focused on several key areas including the concern about monitoring, mitigating, and managing extreme events; budgetary pressures the agency faces in current fiscal year (FY) 2012 and in FY 2013, with President Barack Obama on 18 November having signed into law a bill, HR 2112, following congressional agreement on a budget legislation conference report; and NOAA's newly released scientific integrity policy (see "NOAA issues scientific integrity policy," Eos Trans. AGU, 92(50), 467, doi:10.1029/2011EO500004, 2011).

  3. Administrative Uses of the Microcomputer.

    ERIC Educational Resources Information Center

    Spuck, Dennis W.; Atkinson, Gene

    1983-01-01

    An outline of microcomputer applications for administrative computing in education is followed by discussions of aspects of office automation, database management systems, management information systems, administrative computer systems, and software. Several potential problems relating to administrative computing in education are identified.…

  4. Administrators' Decisions about Resource Allocation

    ERIC Educational Resources Information Center

    Knight, William E.; Folkins, John W.; Hakel, Milton D.; Kennell, Richard P.

    2011-01-01

    Do academic administrators make decisions about resource allocation differently depending on the discipline receiving the funding? Does an administrator's academic identity influence these decisions? This study explored those questions with a sample of 1,690 academic administrators at doctoral-research universities. Participants used fictional…

  5. Three Generations of Educational Administration.

    ERIC Educational Resources Information Center

    Sharpe, F. G.

    This paper compares two Australian educational administration texts published in 1963 to reflect critically on the radical changes that have occurred in educational administration in Australia since then. The books are "Headmasters for Better Schools," by Bassett, Crane, and Walker; and "Training the Administrator," by…

  6. Certification of Financial Aid Administrators

    ERIC Educational Resources Information Center

    Peterson, Stacey A.

    2011-01-01

    The certification of financial aid administrators has been debated for over 37 years. A job satisfaction survey conducted by the National Association of Student Financial Aid Administrators (NASFAA, 2008a) revealed that college and university administrators' perceptions of the efficiency, effectiveness, and quality of the services provided by the…

  7. The Cultural Context of Administration.

    ERIC Educational Resources Information Center

    Ortiz, Flora Ida

    To explicate the relevance of cultural context to educational administration practices, this paper contrasts United States cultural attitudes and administrative practices with those of Latin America. Drawing on Leslie A. White's definition of culture, the author presents the Weberian model of administration as exemplary for the United States,…

  8. Comparing Administrators' Perceptions of SBM.

    ERIC Educational Resources Information Center

    Jacobson, Stephen L.; Woodworth, Beth

    The purpose of this study was to examine the perceptions of administrators of small rural districts hold about school-based management (SBM) and to compare them with the perceptions of administrators in larger, nonrural districts. Administrators' perceptions of what should occur in SBM were compared with what they perceived does occur. Responses…

  9. 75 FR 7045 - Key Gas Components, Inc., Marion, NC; Notice of Negative Determination Regarding Application for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-16

    ... Employment and Training Administration Key Gas Components, Inc., Marion, NC; Notice of Negative Determination... administrative reconsideration of the Department's negative determination regarding eligibility to apply for... of facts or of the law justified reconsideration of the decision. The negative determination of...

  10. Mechanism-based inactivation of hepatic cytochrome P450 2C6 and P450 3A1 following in vivo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine to rats: differences from previously observed in vitro results.

    PubMed

    Kimmett, S M; McNamee, J P; Marks, G S

    1994-04-01

    Using progesterone 21-hydroxylase as a selective substrate for P450 2C6 in phenobarbital-treated male rats, and androstenedione and progesterone 6 beta-hydroxylases as well as erythromycin N-demethylase as selective markers for P450 3A1 in dexamethasone-treated female rats, we have shown that these P450 isozymes undergo mechanism-based inactivation after in vivo administration of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-ethylpyridine (4-ethyl DDC). These results differ from our previous studies where no inactivation was observed after in vitro administration of 4-ethyl DDC to rat hepatic microsomes. We show that the differences between the in vivo and in vitro effects of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) analogues are due to the presence of residual 4-ethyl DDC in the in vitro experiments causing time-independent competitive inhibition and obscuring observation of mechanism-based inactivation.

  11. Ares Knowledge Capture: Summary and Key Themes Presentation

    NASA Technical Reports Server (NTRS)

    Coates, Ralph H.

    2011-01-01

    This report has been developed by the National Aeronautics and Space Administration (NASA) Human Exploration and Operations Mission Directorate (HEOMD) Risk Management team in close coordination with the MSFC Chief Engineers Office. This document provides a point-in-time, cumulative, summary of actionable key lessons learned derived from the design project. Lessons learned invariably address challenges and risks and the way in which these areas have been addressed. Accordingly the risk management thread is woven throughout the document.

  12. Key Concepts in Microbial Oceanography

    NASA Astrophysics Data System (ADS)

    Bruno, B. C.; Achilles, K.; Walker, G.; Weersing, K.; Team, A

    2008-12-01

    The Center for Microbial Oceanography: Research and Education (C-MORE) is a multi-institution Science and Technology Center, established by the National Science Foundation in 2006. C-MORE's research mission is to facilitate a more comprehensive understanding of the diverse assemblages of microorganisms in the sea, ranging from the genetic basis of marine microbial biogeochemistry including the metabolic regulation and environmental controls of gene expression, to the processes that underpin the fluxes of carbon, related bioelements, and energy in the marine environment. The C-MORE education and outreach program is focused on increasing scientific literacy in microbial oceanography among students, educators, and the general public. A first step toward this goal is defining the key concepts that constitute microbial oceanography. After lengthy discussions with scientists and educators, both within and outside C-MORE, we have arrived at six key concepts: 1) Marine microbes are very small and have been around for a long time; 2) Life on Earth could not exist without microbes; 3) Most marine microbes are beneficial; 4) Microbes are everywhere: they are extremely abundant and diverse; 5) Microbes significantly impact our global climate; and 6) There are new discoveries every day in the field of microbial oceanography. A C-MORE-produced brochure on these six key concepts will be distributed at the meeting. Advanced copies may be requested by email or downloaded from the C-MORE web site(http://cmore.soest.hawaii.edu/downloads/MO_key_concepts_hi-res.pdf). This brochure also includes information on career pathways in microbial oceanography, with the aim of broadening participation in the field. C-MORE is eager to work in partnership to incorporate these key concepts into other science literacy publications, particularly those involving ocean and climate literacy. We thank the following contributors and reviewers: P Chisholm, A Dolberry, and A Thompson (MIT); N Lawrence

  13. Teachers' Expectations and School Administration: Keys of Better Communication in Schools

    ERIC Educational Resources Information Center

    Aslanargun, Engin

    2015-01-01

    Problem Statement: The quality of education carried out in schools depends largely on the performance of teachers and school principals in cooperation. It is possible to say that a qualified education of students depends on the performance and compliance degree of these two groups. In this process, teachers' having the primary responsibility for…

  14. Beyond the brochure. Administrators play key role in positioning the practice, aligning marketing with mission.

    PubMed

    Redling, Bob

    2007-04-01

    Marketing doesn't start and stop with a glossy brochure, a display ad in the local Yellow Pages or a Web site. Those are merely tactics that a medical group practice might use to position its physicians' services in the community. Marketing and planning support a medical group's mission and vision--and its strategic plan. The adminstrator must demonstrate this connection to physicians and educate them about what marketing really is.

  15. Key Questions on the Obama Administration's 2013 Education Budget Request: Federal Education Budget Project. Issue Brief

    ERIC Educational Resources Information Center

    New America Foundation, 2012

    2012-01-01

    President Barack Obama submitted his third budget request to Congress on February 13th, 2012. The budget request includes proposed funding levels for all federal programs and agencies in aggregate for the upcoming 10 fiscal years, and specific fiscal year 2013 funding levels for programs subject to the annual appropriations process. It is…

  16. Burnout among Special Education Administrators: A Preliminary Study

    ERIC Educational Resources Information Center

    Carter, Susan J.

    2011-01-01

    Research on the extent of stress and burnout among special education administrators is not as well developed as research on the extent of stress and burnout among teachers. This study utilized the Maslach Burnout Inventory to determine levels of stress and burnout among administrators of special education. Results indicated administrators of…

  17. Performance of device-independent quantum key distribution

    NASA Astrophysics Data System (ADS)

    Cao, Zhu; Zhao, Qi; Ma, Xiongfeng

    2016-07-01

    Quantum key distribution provides information-theoretically-secure communication. In practice, device imperfections may jeopardise the system security. Device-independent quantum key distribution solves this problem by providing secure keys even when the quantum devices are untrusted and uncharacterized. Following a recent security proof of the device-independent quantum key distribution, we improve the key rate by tightening the parameter choice in the security proof. In practice where the system is lossy, we further improve the key rate by taking into account the loss position information. From our numerical simulation, our method can outperform existing results. Meanwhile, we outline clear experimental requirements for implementing device-independent quantum key distribution. The maximal tolerable error rate is 1.6%, the minimal required transmittance is 97.3%, and the minimal required visibility is 96.8 % .

  18. Effects of acute and chronic administration of venlafaxine and desipramine on extracellular monoamine levels in the mouse prefrontal cortex and striatum.

    PubMed

    Higashino, Kosuke; Ago, Yukio; Umehara, Masato; Kita, Yuki; Fujita, Kazumi; Takuma, Kazuhiro; Matsuda, Toshio

    2014-04-15

    Prefrontal catecholamine neurotransmission plays a key role in the therapeutic actions of drugs for attention-deficit/hyperactivity disorder (ADHD). We have recently shown that serotonin/noradrenaline reuptake inhibitors and the noradrenaline reuptake inhibitor desipramine attenuated horizontal hyperactivity in spontaneously hypertensive rats, an animal model of ADHD, and that these drugs are potential pharmacotherapeutics for ADHD. In this study, we used in vivo microdialysis to study the effects of acute and chronic (once daily for 3 weeks) administration of the serotonin/noradrenaline reuptake inhibitor venlafaxine and the noradrenaline reuptake inhibitor desipramine on noradrenaline, dopamine, and serotonin levels, and the expression of the neuronal activity marker c-Fos in the mouse prefrontal cortex and striatum. Both acute and chronic venlafaxine administration increased prefrontal noradrenaline, dopamine, and serotonin levels and striatal noradrenaline and serotonin levels. Both acute and chronic desipramine administration increased prefrontal noradrenaline and dopamine levels and striatal noradrenaline levels, with chronic administration yielding stronger increase. Chronic desipramine did not affect striatal dopamine and serotonin levels. Both acute and chronic venlafaxine administration increased the expression of c-Fos in the prefrontal cortex, whereas chronic, but not acute, desipramine administration increased the expression of c-Fos in the prefrontal cortex. Both acute and chronic venlafaxine administration increased the striatal c-Fos expression to some degree, whereas desipramine administration did not. These results suggest that acute and chronic venlafaxine and chronic desipramine administration maximally activate the prefrontal adrenergic and dopaminergic systems without affecting striatal dopaminergic systems in mice.

  19. Community College Administrative Roles in Identifying Faculty for Future Management Positions: A Phenomenological Study of Retired Administrators

    ERIC Educational Resources Information Center

    Knirk, Brian Doyle

    2013-01-01

    The community college system is beginning to see waves of retirements at all levels of the administrative structure. These retirements, in conjunction with expected growth in administrative positions, will result in system-wide administrative vacancies. Community colleges not already seeking new leaders are likely to find themselves in the midst…

  20. Post-quantum key exchange protocols

    NASA Astrophysics Data System (ADS)

    Li, Xiangdong; Leung, Lin; Kwan, Andis Chi-Tung; Zhang, Xiaowen; Kahanda, Dammika; Anshel, Michael

    2006-05-01

    If an eavesdropper Eve is equipped with quantum computers, she can easily break the public key exchange protocols used today. In this paper we will discuss the post-quantum Diffie-Hellman key exchange and private key exchange protocols.

  1. Key paediatric messages from Amsterdam

    PubMed Central

    Barben, Jürg; Bohlin, Kajsa; Everard, Mark L.; Hall, Graham; Pijnenburg, Mariëlle; Priftis, Kostas N.; Rusconi, Franca; Midulla, Fabio

    2016-01-01

    The Paediatric Assembly of the European Respiratory Society (ERS) maintained its high profile at the 2015 ERS International Congress in Amsterdam. There were symposia on preschool wheeze, respiratory sounds and cystic fibrosis; an educational skills workshop on paediatric respiratory resuscitation; a hot topic session on risk factors and early origins of respiratory diseases; a meet the expert session on paediatric lung function test reference values; and the annual paediatric grand round. In this report the Chairs of the Paediatric Assembly's Groups highlight the key messages from the abstracts presented at the Congress. PMID:27730186

  2. One-way quantum key distribution: Simple upper bound on the secret key rate

    SciTech Connect

    Moroder, Tobias; Luetkenhaus, Norbert; Curty, Marcos

    2006-11-15

    We present a simple method to obtain an upper bound on the achievable secret key rate in quantum key distribution (QKD) protocols that use only unidirectional classical communication during the public-discussion phase. This method is based on a necessary precondition for one-way secret key distillation; the legitimate users need to prove that there exists no quantum state having a symmetric extension that is compatible with the available measurements results. The main advantage of the obtained upper bound is that it can be formulated as a semidefinite program, which can be efficiently solved. We illustrate our results by analyzing two well-known qubit-based QKD protocols: the four-state protocol and the six-state protocol.

  3. EPA's Reanalysis of Key Issues Related to Dioxin Toxicity and ...

    EPA Pesticide Factsheets

    EPA is releasing for external peer review and public comment an important draft document reviewing the literature on the health effects of dioxin and related compounds (also referred to as 2,3,7,8-Tetrachlorodibenzo-p-dioxin). At the request of Administrator Jackson, EPA is in the process of re-assessing the science on the effects of dioxin, a toxic chemical that is emitted by multiple sources, on the public’s health. This draft dioxin report is EPA’s response to key comments and recommendations made by the National Academy of Sciences on the Agency’s draft dioxin reassessment. This assessment has been in progress for many years and raises health issues of broad interest to scientists and policymakers across the federal family. The Agency’s draft report includes significant new analyses on potential cancer and non-cancer human health effects that may result from exposures to dioxins and includes an oral reference dose for what is considered to be the most toxic of the dioxin-like compounds. EPA’s Science

  4. Public/private key certification authority and key distribution. Draft

    SciTech Connect

    Long, J.P.; Christensen, M.J.; Sturtevant, A.P.; Johnston, W.E.

    1995-09-25

    Traditional encryption, which protects messages from prying eyes, has been used for many decades. The present concepts of encryption are built from that heritage. Utilization of modern software-based encryption techniques implies much more than simply converting files to an unreadable form. Ubiquitous use of computers and advances in encryption technology coupled with the use of wide-area networking completely changed the reasons for utilizing encryption technology. The technology demands a new and extensive infrastructure to support these functions. Full understanding of these functions, their utility and value, and the need for an infrastructure, takes extensive exposure to the new paradigm. This paper addresses issues surrounding the establishment and operation of a key management system (i.e., certification authority) that is essential to the successful implementation and wide-spread use of encryption.

  5. KEY COMPARISON: Final report on CCQM-K69 key comparison: Testosterone glucuronide in human urine

    NASA Astrophysics Data System (ADS)

    Liu, Fong-Ha; Mackay, Lindsey; Murby, John

    2010-01-01

    The CCQM-K69 key comparison of testosterone glucuronide in human urine was organized under the auspices of the CCQM Organic Analysis Working Group (OAWG). The National Measurement Institute Australia (NMIA) acted as the coordinating laboratory for the comparison. The samples distributed for the key comparison were prepared at NMIA with funding from the World Anti-Doping Agency (WADA). WADA granted the approval for this material to be used for the intercomparison provided the distribution and handling of the material were strictly controlled. Three national metrology institutes (NMIs)/designated institutes (DIs) developed reference methods and submitted data for the key comparison along with two other laboratories who participated in the parallel pilot study. A good selection of analytical methods and sample workup procedures was displayed in the results submitted considering the complexities of the matrix involved. The comparability of measurement results was successfully demonstrated by the participating NMIs. Only the key comparison data were used to estimate the key comparison reference value (KCRV), using the arithmetic mean approach. The reported expanded uncertainties for results ranged from 3.7% to 6.7% at the 95% level of confidence and all results agreed within the expanded uncertainty of the KCRV. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).

  6. Mapping the literature of nursing administration

    PubMed Central

    Galganski, Carol J.

    2006-01-01

    Objectives: As part of Phase I of a project to map the literature of nursing, sponsored by the Nursing and Allied Health Resources Section of the Medical Library Association, this study identifies the core literature cited in nursing administration and the indexing services that provide access to the core journals. The results of this study will assist librarians and end users searching for information related to this nursing discipline, as well as database producers who might consider adding specific titles to their indexing services. Methods: Using the common methodology described in the overview article, five source journals for nursing administration were identified and selected for citation analysis over a three-year period, 1996 to 1998, to identify the most frequently cited titles according to Bradford's Law of Scattering. From this core of most productive journal titles, the bibliographic databases that provide the best access to these titles were identified. Results: Results reveal that nursing administration literature relies most heavily on journal articles and on those titles identified as core nursing administrative titles. When the indexing coverage of nine services is compared, PubMed/MEDLINE and CINAHL provide the most comprehensive coverage of this nursing discipline. Conclusions: No one indexing service adequately covers this nursing discipline. Researchers needing comprehensive coverage in this area must search more than one database to effectively research their projects. While PubMed/MEDLINE and CINAHL provide more coverage for this discipline than the other indexing services, none is sufficiently broad in scope to provide indexing of nursing, health care management, and medical literature in a single file. Nurse administrators using the literature to research current work issues need to review not only the nursing titles covered by CINAHL but should also include the major weekly medical titles, core titles in health care administration, and

  7. Tying Diverse Student and Administrative Data Bases Together.

    ERIC Educational Resources Information Center

    Rokicki, Phillip S.; Springer, Peggy

    Guidelines for colleges seeking to interface their diverse student and administrative databases are presented. The following key concepts are addressed that need to be understood before solving the problem of sharing and transmitting data between diverse databases: effective management of data from an institutional and a user point of view; the…

  8. Enculturation, Not Alchemy: Professionalizing Novice Writing Program Administrators.

    ERIC Educational Resources Information Center

    Peters, Bradley

    1998-01-01

    Discusses a process of acculturation in three stages by which fledgling Writing Program Administrators can be transformed into change agents: (1) critically reading the program to locate key allies, potential advocates, and proven adversaries; (2) implementing changes on an infrastructural level to convert positive relations among colleagues into…

  9. Educational Administration and the Management of Knowledge: 1980 Revisited

    ERIC Educational Resources Information Center

    Bates, Richard

    2013-01-01

    This paper revisits the thesis of a 1980 paper that suggested a new approach to educational administration based upon the New Sociology of Education. In particular it updates answers to the six key questions asked by that paper: what counts as knowledge; how is what counts as knowledge organised; how is what counts as knowledge transmitted; how is…

  10. Institutional Image: The Concept and Implications for Administrative Action.

    ERIC Educational Resources Information Center

    Renihan, Frederick I; Renihan, Patrick J.

    1989-01-01

    Explores institutional image as a key to providing a philosophy and a logical foundation for school improvement efforts. Identifies two image dimensions (cosmetic and pastoral) and classifies five school types (synergistic, candy store, disaffected, monastic, and survivor), and discusses implications for administrative action. Includes three…

  11. The Role of GABAB Receptors in Morphine Self-Administration

    PubMed Central

    Ramshini, Effat; Alaei, Hojjatallah; Reisi, Parham; Alaei, Samaneh; Shahidani, Somaye

    2013-01-01

    Background: There is only little information about the effects of GABA receptors agonist and antagonist on morphine self-administration. Present study was designed to assess role of GABAB receptors in the regulation of morphine-reinforced self-administration. Methods: This study was performed in four groups of rats: (1) Saline group, which received saline in the self-administration session. (2) Morphine group, which received morphine in saline solution in the self-administration session. (3) Baclofen + Morphine group, which received both baclofen 20 min before self- administration test and morphine in the self-administration session. (4) Phaclofen + Morphine group, which received both phaclofen 20 min before self- administration test and morphine in the self-administration session. The number of lever pressing and self-infusion were recorded. Results: Morphine significantly increased the number of active lever pressing dose dependently in self-administration session in comparative with saline group. Administration of baclofen, 20 min before morphine self-administration produced significant decrease in the initiation of morphine self-administration during all session. Conversely, pre-treatment of phaclofen increased the number of active lever pressing and self-infusion in this test. Conclusion: Our results indicated a short-term treatment by baclofen, reduced morphine-maintenance response in a dose-dependent manner, suggesting that GABAB receptor agonists could be useful for reversing the neuroadaptations related to opiates. PMID:23542877

  12. [Administrative support for Asperger's syndrome].

    PubMed

    Yamaoka, Shu

    2007-03-01

    In recent years, administrative support for developmental disabilities, such as Asperger's syndrome, has come to be conspicuous with "Law for Supporting Persons with Developmental Disabilities", which went into effect in 2005, and promotion of "Special Support Education". However, these supports are still insufficient, because administrative support for the Asperger's syndrome in Japan, having just started very recently. Developmental disabilities, such as Asperger's syndrome, are by no means mild as disabilities, it is required to fill up administrative support for them from now on.

  13. Development management for nursing administration.

    PubMed

    Heyden, R; Luyas, G; Henry, B

    1990-04-01

    What are the needs of a nurse administrator in a developing country? For that matter, what are the requirements for a nurse administrator in areas of lesser developed delivery in this country (e.g., care of the homeless, care of indigent populations)? Heyden, Luyas, and Henry look at the educational needs of these nurse managers and compare the needs to the typical education received in nursing administration programs.

  14. Training for Effective School Administrators.

    ERIC Educational Resources Information Center

    Cawelti, Gordon

    1982-01-01

    Describes a human resources development program for school administrators, including training in management functions, leader behavior skills, instructional leadership skills, and more traditional topics. (Author/JM)

  15. Ethical Dilemmas in Administrative Practice.

    ERIC Educational Resources Information Center

    Price, David W.

    1997-01-01

    Discusses the dimensions of ethics in administrative practice, identifies some of the characteristic circumstances that frequently precipitate ethical dilemmas, and suggests strategies for addressing ethical dilemmas. (Author)

  16. 75 FR 48309 - First Antidumping Duty Administrative Review of Sodium Hexametaphosphate from the People's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-10

    ... International Trade Administration First Antidumping Duty Administrative Review of Sodium Hexametaphosphate from... first administrative review of sodium hexametaphosphate (``sodium hex'') from the People's Republic of... Review of Sodium Hexametaphosphate from the People's Republic of China: Notice of Preliminary Results...

  17. The Educational Administrator's Survival Guide to Administrative Uses of Microcomputers.

    ERIC Educational Resources Information Center

    Florida State Dept. of Education, Tallahassee. Div. of Public Schools.

    Guidelines are presented for use by educational administrators in selecting a microcomputer for administrative purposes. The selection process described is based on the determination of functions to be automated, and the identification of the software that best automates these functions. Topics addressed include general software applications that…

  18. Inhibition of nociceptive responses after systemic administration of amidated kyotorphin

    PubMed Central

    Ribeiro, MMB; Pinto, A; Pinto, M; Heras, M; Martins, I; Correia, A; Bardaji, E; Tavares, I; Castanho, M

    2011-01-01

    BACKGROUND AND PURPOSE Kyotorphin (KTP; L-Tyr-L-Arg), an endogenous neuropeptide, is potently analgesic when delivered directly to the central nervous system. Its weak analgesic effects after systemic administration have been explained by inability to cross the blood–brain barrier (BBB) and detract from the possible clinical use of KTP as an analgesic. In this study, we aimed to increase the lipophilicity of KTP by amidation and to evaluate the analgesic efficacy of a new KTP derivative (KTP-amide – KTP-NH2). EXPERIMENTAL APPROACH We synthesized KTP-NH2. This peptide was given systemically to assess its ability to cross the BBB. A wide range of pain models, including acute, sustained and chronic inflammatory and neuropathic pain, were used to characterize analgesic efficacies of KTP-NH2. Binding to opioid receptors and toxicity were also measured. KEY RESULTS KTP-NH2, unlike its precursor KTP, was lipophilic and highly analgesic following systemic administration in several acute and chronic pain models, without inducing toxic effects or affecting motor responses and blood pressure. Binding to opioid receptors was minimal. KTP-NH2 inhibited nociceptive responses of spinal neurons. Its analgesic effects were prevented by intrathecal or i.p. administration of naloxone. CONCLUSIONS AND IMPLICATIONS Amidation allowed KTP to show good analgesic ability after systemic delivery in acute and chronic pain models. The indirect opioid-mediated actions of KTP-NH2 may explain why this compound retained its analgesic effects although the usual side effects of opioids were absent, which is a desired feature in next-generation pain medications. PMID:21366550

  19. Quantum Public-Key Cryptosystem

    NASA Astrophysics Data System (ADS)

    Luo, Ming-Xing; Chen, Xiu-Bo; Yun, Deng; Yang, Yi-Xian

    2012-03-01

    Quantum one-way functions play a fundamental role in cryptography because of its necessity for the secure encryption schemes taking into account the quantum computer. In this paper our purpose is to establish a theoretical framework for a candidate of the quantum one-way functions and quantum trapdoor functions based on one-parameter unitary groups. The dynamics of parameterized unitary groups ensure the one-wayness and quantum undistinguishability in different levels, and the physical feasibility are derived from the simultaneous approximation of its infinitesimal generators. Moreover, these special functions are used to construct new cryptosystems-the quantum public-key cryptosystems for encrypting both the classical and quantum information.

  20. Applied public-key steganography

    NASA Astrophysics Data System (ADS)

    Guillon, Pierre; Furon, Teddy; Duhamel, Pierre

    2002-04-01

    We consider the problem of hiding information in a steganographic framework, i.e. embedding a binary message within an apparently innocuous content, in order to establish a suspicion-free digital communication channel. The adversary is passive as no intentional attack is foreseen. The only threat is that she discovers the presence of a hidden communication. The main goal of this article is to find if the Scalar Costa Scheme, a recently published embedding method exploiting side information at the encoder, is suitable for that framework. We justify its use assessing its security level with respect to the Cachin's criterion. We derive a public-key stego-system following the ideas of R. Anderson and P. Petitcolas. This technique is eventually applied to PCM audio contents. Experimental performances are detailed in terms of bit-rate and Kullback-Leibler distance.

  1. SLAR image interpretation keys for geographic analysis

    NASA Technical Reports Server (NTRS)

    Coiner, J. C.

    1972-01-01

    A means for side-looking airborne radar (SLAR) imagery to become a more widely used data source in geoscience and agriculture is suggested by providing interpretation keys as an easily implemented interpretation model. Interpretation problems faced by the researcher wishing to employ SLAR are specifically described, and the use of various types of image interpretation keys to overcome these problems is suggested. With examples drawn from agriculture and vegetation mapping, direct and associate dichotomous image interpretation keys are discussed and methods of constructing keys are outlined. Initial testing of the keys, key-based automated decision rules, and the role of the keys in an information system for agriculture are developed.

  2. Keys and the crisis in taxonomy: extinction or reinvention?

    PubMed

    Walter, David Evans; Winterton, Shaun

    2007-01-01

    Dichotomous keys that follow a single pathway of character state choices to an end point have been the primary tools for the identification of unknown organisms for more than two centuries. However, a revolution in computer diagnostics is now under way that may result in the replacement of traditional keys by matrix-based computer interactive keys that have many paths to a correct identification and make extensive use of hypertext to link to images, glossaries, and other support material. Progress is also being made on replacing keys entirely by optical matching of specimens to digital databases and DNA sequences. These new tools may go some way toward alleviating the taxonomic impediment to biodiversity studies and other ecological and evolutionary research, especially with better coordination between those who produce keys and those who use them and by integrating interactive keys into larger biological Web sites.

  3. A novel key management scheme using biometrics

    NASA Astrophysics Data System (ADS)

    Sui, Yan; Yang, Kai; Du, Yingzi; Orr, Scott; Zou, Xukai

    2010-04-01

    Key management is one of the most important issues in cryptographic systems. Several important challenges in such a context are represented by secure and efficient key generation, key distribution, as well as key revocation. Addressing such challenges requires a comprehensive solution which is robust, secure and efficient. Compared to traditional key management schemes, key management using biometrics requires the presence of the user, which can reduce fraud and protect the key better. In this paper, we propose a novel key management scheme using iris based biometrics. Our newly proposed scheme outperforms traditional key management schemes as well as some existing key-binding biometric schemes in terms of security, diversity and/or efficiency.

  4. [Treatment adherence: a key element].

    PubMed

    Bastida, Guillermo; Sánchez Montes, Cristina; Aguas, Mariam

    2011-12-01

    A substantial percentage of patients fail to follow health professionals' recommendations, which affects the management of chronic diseases, reducing the effectiveness of therapeutic interventions and increasing the costs of the disease. Lack of adherence is a multidimensional phenomenon and is influenced by numerous factors that should be identified. A multiplicity of measures is available to improve adherence, such as simplifying treatment administration, but none of these measures is effective when used alone. One way of tackling lack of adherence is by identifying patients' barriers to medication and involving them in decision making. Ulcerative colitis (UC) poses a risk for lack of treatment adherence. In this disease, poor adherence correlates with poor disease control (drug effectiveness) and with higher costs. As in other chronic diseases, the causes associated with poor adherence are multiple, including psychosocial factors, the physician-patient relationship and patients' prejudices toward medication. A single dose of aminosalycylates (5-ASA) should be recommended, as this dose is as safe and effective as other regimens. However, by itself, this recommendation does not seem to improve adherence. Identifying the scale of the problem and developing strategies to involve the patient in decision making is crucial to improve treatment adherence.

  5. Food irradiation: Key research needs

    SciTech Connect

    Morehouse, K.M. )

    1993-01-01

    Treatment of foods with ionizing radiation reduces microbial infection and insect infestations, inhibits sprouting, and delays maturation, thereby extending the shelf life of foods. The treatment of different types of foods with ionizing radiation for specific purposes is accepted in several countries, although it is prohibited in others. The US Food and Drug Administration has established regulations to allow the treatment of several different foods with ionizing radiation and has received petitions for the approval of radiation treatment of additional foods. When carried out according to established good manufacturing practices, food irradiation yields safe, wholesome foods. The irradiated product may be often chemically or microbiologically [open quotes]safer[close quotes] than the nonirradiated product. This paper presents several areas of scientific research in which more information would facilitate the expansion of this technology and points out major areas of concern. The question of the public acceptance of foods that have been treated with ionizing radiation is discussed only briefly in order to make the presentation complete.

  6. Principals' Values in School Administration

    ERIC Educational Resources Information Center

    Aslanargun, Engin

    2012-01-01

    School administration is value driven area depending on the emotions, cultures, and human values as well as technique and structure. Over the long years, educational administration throughout the world have experienced the influence of logical positivism that is based on rational techniques more than philosophical consideration, ignored values and…

  7. Attitudes, Administrative Styles, and Outcomes.

    ERIC Educational Resources Information Center

    Laughlin, J. Stanley

    1984-01-01

    The literature on administrative style is reviewed. Attention is directed to four basic concepts of administrative style: (1) the structured, classical, traditional model; (2) the participatory or employee-involved operation; (3) a more behavioral scientific style; and (4) the situational or environmental style. These ideas are more fully…

  8. Network Systems Administration Needs Assessment.

    ERIC Educational Resources Information Center

    Lexington Community Coll., KY. Office of Institutional Research.

    In spring 1996, Lexington Community College (LCC) in Kentucky, conducted a survey to gather information on employment trends and educational needs in the field of network systems administration (NSA). NSA duties involve the installation and administration of network operating systems, applications software, and networking infrastructure;…

  9. Selecting Child Care Administrative Software.

    ERIC Educational Resources Information Center

    Kalinowski, Michael

    1998-01-01

    Offers advice on the selection of child care administrative software. Directors should consider needs, computer experience, budget, time, and temperament, and should also ask lots of questions and test demo versions. Choices range from custom programs and existing business products to child care administrative software packages. Includes directory…

  10. Development Management for Nursing Administration.

    ERIC Educational Resources Information Center

    Heyden, Richard; And Others

    1990-01-01

    Discusses the educational needs of nurse administrators in developing counties and in areas of lesser development in the United States and compares them to the typical education received in nursing administration programs. Concludes that a focus on development management is needed. (JOW)

  11. Public Finance Administration. Second Edition.

    ERIC Educational Resources Information Center

    Reed, B. J.; Swain, John W.

    This book is intended for the nonexpert in finance who has a public administration background. It opens with a broad introduction to public finance administration and how this job is related to public budgeting, the practice of public-sector accounting, and the economic concepts of money and value. Issues surrounding public revenue, its sources,…

  12. Faculty Perspectives on Administrator Effectiveness.

    ERIC Educational Resources Information Center

    Bess, James L.

    The sources of faculty perspectives on the personal effectiveness of administrators are analyzed. It is proposed that faculty will be predisposed to see administrators in different lights, depending on structural elements in decision making and the orientation of the faculty members. Attention is directed to Talcott Parson's theory for classifying…

  13. The Magic of Library Administration.

    ERIC Educational Resources Information Center

    Holley, Edward G.

    We are better prepared today to deal with the problems in library administration, because we not only have the basic work of management theorists, but also staffs who are better educated and more interested in participation. During the last 25 years, there have been two strands in library administration. The older, human relations approach allowed…

  14. Outsourcing real estate lease administration.

    PubMed

    Kardel, S

    1996-09-01

    Real estate lease administration is becoming increasingly important to healthcare organizations; however, not all organizations possess the in-house expertise to carry out this specialized function. For such organizations, outsourcing lease administration may be a more efficient way to manage their real estate portfolios and possibly improve their bottom lines.

  15. Cardinal Virtues of Academic Administration

    ERIC Educational Resources Information Center

    Curren, Randall

    2008-01-01

    The aim of this article is to articulate the basic elements of a comprehensive ethic of academic administration, organized around a set of three cardinal virtues: "commitment" to the good of the institution; good administrative "judgment"; and "conscientiousness" in discharging the duties of the office. In addition to explaining this framework and…

  16. College Administration: Concepts and Techniques.

    ERIC Educational Resources Information Center

    Feltner, Bill D., Ed.

    Ten colleges participated in a project to: (1) help organize and strengthen administrative teams in developing two-year and four-year colleges throughout the Southeast; (2) to assist administrative teams in identifying specific roles for each team member and in developing an understanding of team responsibilities; and (3) to assist administrative…

  17. Expanding Role of the Administrator.

    ERIC Educational Resources Information Center

    Gibb, Jack R.

    The role of the secondary school administrator can be viewed in two ways: From a defensive point of view with the administrator marshaling the forces of organization, stimulating effort, capturing the imagination, inspiring teachers, coordinating efforts, and serving as a model of sustained effort; or from an alternative point of view with the…

  18. Idaho Driver Education Administrative Guide.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise.

    This guide provides information for school administrators and directors of commercial driver training schools about conducting driver education courses in Idaho. The first part of the guide, which applies to both public schools and commercial schools, covers the following areas: administration, sample letters and forms, instructional time…

  19. Educational Administration: The Developing Decades.

    ERIC Educational Resources Information Center

    Cunningham, Luvern L., Ed.; And Others

    This book consists of 18 papers originally prepared for a 1975 conference that attempted to assess past developments in the knowledge and practice of educational administration and to identify future directions for research, leadership, and preparation. Individual papers include "Educational Administration, 1954-1974,""Roald F. Campbell: Teacher,…

  20. The Dissimilarity of Educational Administration

    ERIC Educational Resources Information Center

    Walton, John

    1970-01-01

    The responsibilities of educational administrators do not extend to the products of the educational institutions. Rather, they end at the point where they maintain satisfactory conditions for leisure activities. In this respect, educational administration may serve as a model for the governance of an increasing number of organizations, both public…

  1. The Enigma of Administrative Behaviour.

    ERIC Educational Resources Information Center

    Batchler, Merv

    1981-01-01

    Writers attempting to describe administration have approached the subject from a number of perspectives. Researchers such as Gulick (1937) identified planning, organizing, staffing, directing, coordinating, reporting, and budgeting as functional elements of administration. Hemphill, Griffiths, and Fredericksen (1962), using simulated job settings,…

  2. There Was a Door to Which I Found No Key.

    ERIC Educational Resources Information Center

    Berg, Paul C.

    Teachers have tried many "keys," some misused or ineffective, and should continue to search for effective keys to open the doors of reading for their students. Results of recent student testing programs indicate that student knowledge is on the decline, suggesting in turn that reading is a declining art. Television may be a major culprit; recent…

  3. Answering Key Fuel Cycle Questions

    SciTech Connect

    Steven J. Piet; Brent W. Dixon; J. Stephen Herring; David E. Shropshire; Mary Lou Dunzik-Gougar

    2003-10-01

    The Advanced Fuel Cycle Initiative (AFCI) program has both “outcome” and “process” goals because it must address both waste already accumulating as well as completing the fuel cycle in connection with advanced nuclear power plant concepts. The outcome objectives are waste geological repository capacity and cost, energy security and sustainability, proliferation resistance, fuel cycle economics, and safety. The process objectives are readiness to proceed and adaptability and robustness in the face of uncertainties. A classic decision-making approach to such a multi-attribute problem would be to weight individual quantified criteria and calculate an overall figure of merit. This is inappropriate for several reasons. First, the goals are not independent. Second, the importance of different goals varies among stakeholders. Third, the importance of different goals is likely to vary with time, especially the “energy future.” Fourth, some key considerations are not easily or meaningfully quantifiable at present. Instead, at this point, we have developed 16 questions the AFCI program should answer and suggest an approach of determining for each whether relevant options improve meeting each of the program goals. We find that it is not always clear which option is best for a specific question and specific goal; this helps identify key issues for future work. In general, we suggest attempting to create as many win-win decisions (options that are attractive or neutral to most goals) as possible. Thus, to help clarify why the program is exploring the options it is, and to set the stage for future narrowing of options, we have developed 16 questions, as follows: · What are the AFCI program goals? · Which potential waste disposition approaches do we plan for? · What are the major separations, transmutation, and fuel options? · How do we address proliferation resistance? · Which potential energy futures do we plan for? · What potential external triggers do we

  4. Anthelmintic administration to small ruminants in emergency drought responses: assessing the impact in two locations of northern Kenya.

    PubMed

    Okell, Claire Natasha; Mariner, Jeffrey; Allport, Robert; Buono, Nicoletta; Mutembei, Henry M'Ikiugu; Rushton, Jonathan; Verheyen, Kristien

    2016-03-01

    Internal parasites are a significant determinant of the productivity of ruminant species in the tropics. Provision of anthelmintics has become a predominant part of animal health interventions in emergency drought responses, aiming to maintain the food conversion efficiency of livestock when pasture is scarce. This study aimed to assess the owner-perceived impact of anthelmintic provision on the health and productivity of small ruminants in the drought-prone counties of Isiolo and Marsabit, northern Kenya. Participatory approaches were used to retrospectively measure differences in key indicators of livestock output before and after anthelmintic administration. Results showed that there was no perceived impact of anthelmintic administration during droughts on small ruminant health and productivity, but some benefit of anthelmintic administration during rainy season was perceived. The study also provided some evidence of potential differences in the epidemiology of internal parasites between the counties. These findings may be utilised to inform future livestock intervention programmes in drought-prone areas.

  5. Automated Administrative Data Bases

    NASA Technical Reports Server (NTRS)

    Marrie, M. D.; Jarrett, J. R.; Reising, S. A.; Hodge, J. E.

    1984-01-01

    Improved productivity and more effective response to information requirements for internal management, NASA Centers, and Headquarters resulted from using automated techniques. Modules developed to provide information on manpower, RTOPS, full time equivalency, and physical space reduced duplication, increased communication, and saved time. There is potential for greater savings by sharing and integrating with those who have the same requirements.

  6. Finite-size key in the Bennett 1992 quantum-key-distribution protocol for Rényi entropies

    NASA Astrophysics Data System (ADS)

    Mafu, Mhlambululi; Garapo, Kevin; Petruccione, Francesco

    2013-12-01

    A realistic quantum-key-distribution protocol necessarily runs with finite resources. Usually, security proofs for existing quantum key distribution are asymptotic in the sense that certain parameters are exceedingly large compared to practical realistic values. In this paper, we derive bounds on the secret key rates for the Bennett 1992 protocol, which includes a preprocessing step. The derivation for a finite-size key is expressed as an optimization problem by using results from the uncertainty relations and the smooth Rényi entropies.

  7. Key aspects of coronal heating

    PubMed Central

    Klimchuk, James A.

    2015-01-01

    We highlight 10 key aspects of coronal heating that must be understood before we can consider the problem to be solved. (1) All coronal heating is impulsive. (2) The details of coronal heating matter. (3) The corona is filled with elemental magnetic stands. (4) The corona is densely populated with current sheets. (5) The strands must reconnect to prevent an infinite build-up of stress. (6) Nanoflares repeat with different frequencies. (7) What is the characteristic magnitude of energy release? (8) What causes the collective behaviour responsible for loops? (9) What are the onset conditions for energy release? (10) Chromospheric nanoflares are not a primary source of coronal plasma. Significant progress in solving the coronal heating problem will require coordination of approaches: observational studies, field-aligned hydrodynamic simulations, large-scale and localized three-dimensional magnetohydrodynamic simulations, and possibly also kinetic simulations. There is a unique value to each of these approaches, and the community must strive to coordinate better. PMID:25897094

  8. Experience and education of home health administrators and nursing home administrators and the relationship to establishment ownership.

    PubMed

    Decker, Frederic H; Decker, Sandra L

    2012-01-01

    Administrators in long-term care may have an important influence on quality of care. Limited prior research has described the characteristics of nursing home administrators. Despite growing emphasis on home health care as an alternative to nursing homes, almost no research has described the characteristics of administrators of home health agencies. Using the 2004 National Nursing Home Survey and the 2007 National Home and Hospice Care Survey, we describe the career experience of administrators, and examine the relationship between experience and education of administrators both within and across the nursing home and home health sectors. We also explore the characteristics of nursing homes and home health agencies, including establishment ownership (e.g., nonchain not-for-profit), that are associated with being able to attract administrators with the most experience. We find that home health administrators have, on average, less experience than nursing home administrators. Among home health agencies, administrators with the least experience also tend to have less education. In nursing homes, administrators with less experience tend to have more education. Results from multivariate analysis suggest that chain for-profits may be the least able to attract experienced administrators. More research on the effects of different levels of experience and education among administrators is needed.

  9. Quantum key distribution with multi letter alphabets

    NASA Astrophysics Data System (ADS)

    Sych, D.; Leuchs, G.

    2010-03-01

    We present a new protocol for continuous variable quantum key distribution (CV QKD). The novelty of the protocol is a multi letter alphabet represented by coherent states of light with a fixed amplitude and variable phase. Information is encoded in the phase of a coherent state which can be chosen from a regular discrete set consisting, however, of an arbitrary number of letters. We evaluate the security of the protocol against the beam splitting attack. As a result we show the proposed protocol has advantages over the standard two letter coherent state QKD protocol, especially in the case when losses in the communication channel are low.

  10. Floodlight quantum key distribution: A practical route to gigabit-per-second secret-key rates

    NASA Astrophysics Data System (ADS)

    Zhuang, Quntao; Zhang, Zheshen; Dove, Justin; Wong, Franco N. C.; Shapiro, Jeffrey H.

    2016-07-01

    The channel loss incurred in long-distance transmission places a significant burden on quantum key distribution (QKD) systems: they must defeat a passive eavesdropper who detects all the light lost in the quantum channel and does so without disturbing the light that reaches the intended destination. The current QKD implementation with the highest long-distance secret-key rate meets this challenge by transmitting no more than one photon per bit [M. Lucamarini et al., Opt. Express 21, 24550 (2013), 10.1364/OE.21.024550]. As a result, it cannot achieve the Gbps secret-key rate needed for one-time pad encryption of large data files unless an impractically large amount of multiplexing is employed. We introduce floodlight QKD (FL-QKD), which floods the quantum channel with a high number of photons per bit distributed over a much greater number of optical modes. FL-QKD offers security against the optimum frequency-domain collective attack by transmitting less than one photon per mode and using photon-coincidence channel monitoring, and it is completely immune to passive eavesdropping. More importantly, FL-QKD is capable of a 2-Gbps secret-key rate over a 50-km fiber link, without any multiplexing, using available equipment, i.e., no new technology need be developed. FL-QKD achieves this extraordinary secret-key rate by virtue of its unprecedented secret-key efficiency, in bits per channel use, which exceeds those of state-of-the-art systems by two orders of magnitude.

  11. Finite-key security analysis of quantum key distribution with imperfect light sources

    DOE PAGES

    Mizutani, Akihiro; Curty, Marcos; Lim, Charles Ci Wen; ...

    2015-09-09

    In recent years, the gap between theory and practice in quantum key distribution (QKD) has been significantly narrowed, particularly for QKD systems with arbitrarily flawed optical receivers. The status for QKD systems with imperfect light sources is however less satisfactory, in the sense that the resulting secure key rates are often overly dependent on the quality of state preparation. This is especially the case when the channel loss is high. Very recently, to overcome this limitation, Tamaki et al proposed a QKD protocol based on the so-called 'rejected data analysis', and showed that its security in the limit of infinitelymore » long keys is almost independent of any encoding flaw in the qubit space, being this protocol compatible with the decoy state method. Here, as a step towards practical QKD, we show that a similar conclusion is reached in the finite-key regime, even when the intensity of the light source is unstable. More concretely, we derive security bounds for a wide class of realistic light sources and show that the bounds are also efficient in the presence of high channel loss. Our results strongly suggest the feasibility of long distance provably secure communication with imperfect light sources.« less

  12. Finite-key security analysis of quantum key distribution with imperfect light sources

    SciTech Connect

    Mizutani, Akihiro; Curty, Marcos; Lim, Charles Ci Wen; Imoto, Nobuyuki; Tamaki, Kiyoshi

    2015-09-09

    In recent years, the gap between theory and practice in quantum key distribution (QKD) has been significantly narrowed, particularly for QKD systems with arbitrarily flawed optical receivers. The status for QKD systems with imperfect light sources is however less satisfactory, in the sense that the resulting secure key rates are often overly dependent on the quality of state preparation. This is especially the case when the channel loss is high. Very recently, to overcome this limitation, Tamaki et al proposed a QKD protocol based on the so-called 'rejected data analysis', and showed that its security in the limit of infinitely long keys is almost independent of any encoding flaw in the qubit space, being this protocol compatible with the decoy state method. Here, as a step towards practical QKD, we show that a similar conclusion is reached in the finite-key regime, even when the intensity of the light source is unstable. More concretely, we derive security bounds for a wide class of realistic light sources and show that the bounds are also efficient in the presence of high channel loss. Our results strongly suggest the feasibility of long distance provably secure communication with imperfect light sources.

  13. Mechanistic determinants of biotherapeutics absorption following SC administration.

    PubMed

    Richter, Wolfgang F; Bhansali, Suraj G; Morris, Marilyn E

    2012-09-01

    The subcutaneous (SC) route is of growing interest for the administration of biotherapeutics. Key products on the biotherapeutic market such as insulins, but also several immunoglobulins or Fc-fusion proteins, are administered SC. Despite the importance of the SC route, the available knowledge about the processes involved in the SC absorption of biotherapeutics is limited. This review summarizes available information on the physiology of the SC tissue and on the pharmacokinetic processes after SC administration including "first pass catabolism" at the administration site as well as transport in the extracellular matrix of the SC tissue, followed by absorption into the blood circulation or the lymphatic system. Both monoclonal antibodies and other biotherapeutics are discussed. Determinants of absorption after SC administration are summarized including compound properties such as charge or molecular weight. Scale-up of animal data to humans is discussed, including the current shortcomings of empirical scaling approaches and the lack of suitable mechanistic approaches.

  14. EPA's Key Management Challenges - 2016

    EPA Pesticide Factsheets

    Report #16-N-0206, June 16, 2016. Attention to agency management challenges could result in stronger results and protection for the public and increased confidence in management integrity and accountability.

  15. EPA's Key Management Challenges - 2015

    EPA Pesticide Factsheets

    Report #15-N-0164, May 28, 2015. Attention to agency management challenges could result in stronger results and protection for the public, and increased confidence in management integrity and accountability.

  16. Mass drug administration for malaria

    PubMed Central

    Poirot, Eugenie; Skarbinski, Jacek; Sinclair, David; Kachur, S Patrick; Slutsker, Laurence; Hwang, Jimee

    2013-01-01

    Background Mass drug administration (MDA), defined as the empiric administration of a therapeutic antimalarial regimen to an entire population at the same time, has been a historic component of many malaria control and elimination programmes, but is not currently recommended. With renewed interest in MDA and its role in malaria elimination, this review aims to summarize the findings from existing research studies and program experiences of MDA strategies for reducing malaria burden and transmission. Objectives To assess the impact of antimalarial MDA on population asexual parasitaemia prevalence, parasitaemia incidence, gametocytaemia prevalence, anaemia prevalence, mortality and MDA-associated adverse events. Search methods We searched the Cochrane Infectious Disease Group Specialized Register, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE+, EMBASE, to February 2013. We also searched CABS Abstracts, LILACS, reference lists, and recent conference proceedings. Selection criteria Cluster-randomized trials and non-randomized controlled studies comparing therapeutic MDA versus placebo or no MDA, and uncontrolled before-and-after studies comparing post-MDA to baseline data were selected. Studies administering intermittent preventive treatment (IPT) to sub-populations (for example, pregnant women, children or infants) were excluded. Data collection and analysis Two authors independently reviewed studies for inclusion, extracted data and assessed risk of bias. Studies were stratified by study design and then subgrouped by endemicity, by co-administration of 8-aminoquinoline plus schizonticide drugs and by plasmodium species. The quality of evidence was assessed using the GRADE approach. Main results Two cluster-randomized trials, eight non-randomized controlled studies and 22 uncontrolled before-and-after studies are included in this review. Twenty-two studies (29 comparisons) compared MDA to placebo or no intervention of which two comparisons were

  17. 29 CFR 15.6 - Administrative action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... When an organizational unit learns of an incident that reasonably can be expected to result in an... employee of that organizational unit or when it learns of an administrative claim or of litigation alleging... necessary to preserve all relevant documents and other evidence. Each organizational unit should...

  18. Salary Levels for Chief Financial Aid Administrators.

    ERIC Educational Resources Information Center

    Redd, Kenneth E.

    2002-01-01

    Provides information on the median annual salary levels for chief financial aid administrators in 1999-2000 based on results from the Survey of Undergraduate Financial Aid Policies, Practices, and Procedures. Findings indicate that men still have higher salaries than women. (EV)

  19. Research Administration as a Living System

    ERIC Educational Resources Information Center

    Cole, Sharon Stewart

    2007-01-01

    The purpose of this Delphi study was to gather expert opinions and recommendations for change in the research administration system to bring about growth and collaboration. This study was deemed important because at the heart of every system is the fact that individuals need each other to continue to exist. The results of the Delphi study give…

  20. Topical administration of medications in the lungs.

    PubMed

    MCElnay, J C; Summers, R S

    1983-09-01

    A survey has been carried out in Zimbabwe to gain information on pharmacist attitudes and current practice involving patient education in the use of medications for topical administration in the lung. The results of the survey indicated that although there was awareness of patient misuse of the administration devices, most pharmacists did not commonly demonstrate administration techniques to their patients; demonstrations when carried out were predominantly by hospital pharmacists. Few pharmacists were aware of the availability of placebo devices for patient education. Most pharmacists agreed, however, that they would become involved in patient instruction on administration techniques if placebo devices were made available to them. These placebo units, they felt, should be supplied free of charge by the manufacturing companies. Most pharmacists felt that, at present, their patients did not fully understand and were not practising correct administration techniques and therefore required tuition in these matters. The present survey was a pilot study for a larger survey to be carried out in Northern Ireland.

  1. Administrative Simplification, Simplified for Hawai‘i

    PubMed Central

    2012-01-01

    Background The American health care system contains a layer of administrative controls that has become increasingly burdensome to medical practices in terms of uncompensated physician and staff time and practice costs. A primary care physician in solo practice spends between 4 and 10 hours a week directly interacting with health insurance companies and his or her staff will spend an additional 60 hours a week. This reduces patient-care availability, net practice income and physician job satisfaction. Methods A literature review was conducted to determine possible solutions to administrative burdens physicians face in Hawai‘i. A total of 51 articles were found matching search criteria with five being reports from major organizations. Results Twenty-seven articles were found that related to administrative simplification. The “administrative complexity” problem has been defined and its financial impact quantified. Promising solutions have been developed and proposed by private not-for-profit organizations and by the government, both state and federal. Discussion A successful administrative simplification plan would: (1) Provide rapid access to insurance information; (2) Allow medical practices to readily track specific claims; (3) Streamline the preauthorization process through the use of decision-support tools at the practice level and by directing interactions through real-time network connections between insurers and provider electronic health records, thus minimizing phone time; (4) Adopt the Universal Provider Datasource system for provider credentialing; and (5) Standardize (to the greatest degree possible) provider/insurer contracts. These solutions are outlined in detail. PMID:22737644

  2. A Woman Administrator Speaks: Openness and Secrecy in Educational Administration

    ERIC Educational Resources Information Center

    Peterson, Martha

    1975-01-01

    In a speech presented to NAWDAC, NASPA and ACPA in Chicago, April 15, 1974, the author addresses problems encountered by administrators regarding the need to maintain credibility while recognizing theneed to maintain some amount of confidentiality. (HMV)

  3. Intravenous medication administration in intensive care: opportunities for technological solutions.

    PubMed

    Moss, Jacqueline; Berner, Eta; Bothe, Olaf; Rymarchuk, Irina

    2008-11-06

    Medication administration errors have been shown to be frequent and serious. Error is particularly prevalent in highly technical specialties such as critical care. The purpose of this study was to describe the characteristics of intravenous medication administration in five intensive care units. These data were used within the context of a larger study to design information system decision support in these settings. Nurses were observed during the course of their work and their intravenous medication administration process, order source, references used, calculation method, number of medications prepared simultaneously, and any interruptions occurring during the preparation and delivery phases of the administration event were recorded. In addition, chart reviews of medication administration records were completed and nurses were asked to complete an anonymous drop-box questionnaire regarding their experiences with medication administration error. The results of this study are discussed in terms of potential informatics solutions for reducing medication administration error.

  4. Key Working for Families with Young Disabled Children

    PubMed Central

    Carter, Bernie; Thomas, Megan

    2011-01-01

    For families with a disabled child, the usual challenges of family life can be further complicated by the need to access a wide range of services provided by a plethora of professionals and agencies. Key working aims to support children and their families in navigating these complexities ensuring easy access to relevant, high quality, and coordinated care. The aim of this paper is to explore the key worker role in relation to “being a key worker” and “having a key worker”. The data within this paper draw on a larger evaluation study of the Blackpool Early Support Pilot Programme. The qualitative study used an appreciative and narrative approach and utilised mixed methods (interviews, surveys and a nominal group workshop). Data were collected from 43 participants (parents, key workers, and other stakeholders). All stakeholders who had been involved with the service were invited to participate. In the paper we present and discuss the ways in which key working made a difference to the lives of children and their families. We also consider how key working transformed the perspectives of the key workers creating a deeper and richer understanding of family lives and the ways in which other disciplines and agencies worked. Key working contributed to the shift to a much more family-centred approach, and enhanced communication and information sharing between professionals and agencies improved. This resulted in families feeling more informed. Key workers acted in an entrepreneurial fashion, forging new relationships with families and between families and other stakeholders. Parents of young disabled children and their service providers benefited from key working. Much of the benefit accrued came from strong, relational, and social-professional networking which facilitated the embedding of new ways of working into everyday practice. Using an appreciative inquiry approach provided an effective and relevant way of engaging with parents, professionals, and other

  5. Introduction strategies raise key questions.

    PubMed

    Finger, W R; Keller, S

    1995-09-01

    Key issues that must be considered before a new contraceptive is introduced center on the need for a trained provider to begin or terminate the method, its side effects, duration of use, method's ability to meet users' needs and preferences, and extra training or staff requirements. Logistics and economic issues to consider are identifying a dependable way of effectively supplying commodities, planning extra services needed for the method, and cost of providing the method. Each contraceptive method presents a different side effect pattern and burdens the service delivery setting differently. The strategy developed to introduce or expand the 3-month injectable Depo-Provera (DMPA) can be used for any method. It includes a needs assessment and addresses regulatory issues, service delivery policies and procedures, information and training, evaluation, and other concerns. Viet Nam's needs assessment showed that Norplant should not be introduced until the service delivery system becomes stronger. Any needs assessment for expansion of contraceptive services should cover sexually transmitted disease/HIV issues. A World Health Organization strategy helps officials identify the best method mix for local situations. Introductory strategies must aim to improve the quality of family planning programs and expand choices. Many begin by examining existing data and conducting interviews with policymakers, users, providers, and women's health advocates. Introductory programs for Norplant focus on provider training, adequate counseling and informed consent for users, and ready access to removal. They need a well-prepared service delivery infrastructure. The first phase of the DMPA introductory strategy for the Philippines comprised a social marketing campaign and DMPA introduction at public clinics in 10 pilot areas with strong service delivery. Successful AIDS prevention programs show that people tend to use barrier methods when they are available. USAID is currently studying

  6. Cryptographic Key Management and Critical Risk Assessment

    SciTech Connect

    Abercrombie, Robert K

    2014-05-01

    The Department of Energy Office of Electricity Delivery and Energy Reliability (DOE-OE) CyberSecurity for Energy Delivery Systems (CSEDS) industry led program (DE-FOA-0000359) entitled "Innovation for Increasing CyberSecurity for Energy Delivery Systems (12CSEDS)," awarded a contract to Sypris Electronics LLC to develop a Cryptographic Key Management System for the smart grid (Scalable Key Management Solutions for Critical Infrastructure Protection). Oak Ridge National Laboratory (ORNL) and Sypris Electronics, LLC as a result of that award entered into a CRADA (NFE-11-03562) between ORNL and Sypris Electronics, LLC. ORNL provided its Cyber Security Econometrics System (CSES) as a tool to be modified and used as a metric to address risks and vulnerabilities in the management of cryptographic keys within the Advanced Metering Infrastructure (AMI) domain of the electric sector. ORNL concentrated our analysis on the AMI domain of which the National Electric Sector Cyber security Organization Resource (NESCOR) Working Group 1 (WG1) has documented 29 failure scenarios. The computational infrastructure of this metric involves system stakeholders, security requirements, system components and security threats. To compute this metric, we estimated the stakes that each stakeholder associates with each security requirement, as well as stochastic matrices that represent the probability of a threat to cause a component failure and the probability of a component failure to cause a security requirement violation. We applied this model to estimate the security of the AMI, by leveraging the recently established National Institute of Standards and Technology Interagency Report (NISTIR) 7628 guidelines for smart grid security and the International Electrotechnical Commission (IEC) 63351, Part 9 to identify the life cycle for cryptographic key management, resulting in a vector that assigned to each stakeholder an estimate of their average loss in terms of dollars per day of system

  7. Transcultural perspectives in nursing administration.

    PubMed

    Andrews, M M

    1998-11-01

    Population demographics are reshaping the healthcare work force with respect to race, ethnicity, gender, national origin, sexual orientation, age, handicap, disability, and related factors as national sensitivity to various forms of diversity grows. Given the demographic trends, it is inevitable that nurse administrators will need skill in transcultural administration as they manage diversity and identify the cultural origins of conflict in the multicultural workplace. Culture influences the manner in which administrators, staff and patients perceive, identify, define and solve problems. In this article, the complex and interrelated factors that influence workplace diversity are examined.

  8. Accuracy of administrative data for surveillance of healthcare-associated infections: a systematic review

    PubMed Central

    van Mourik, Maaike S M; van Duijn, Pleun Joppe; Moons, Karel G M; Bonten, Marc J M; Lee, Grace M

    2015-01-01

    Objective Measuring the incidence of healthcare-associated infections (HAI) is of increasing importance in current healthcare delivery systems. Administrative data algorithms, including (combinations of) diagnosis codes, are commonly used to determine the occurrence of HAI, either to support within-hospital surveillance programmes or as free-standing quality indicators. We conducted a systematic review evaluating the diagnostic accuracy of administrative data for the detection of HAI. Methods Systematic search of Medline, Embase, CINAHL and Cochrane for relevant studies (1995–2013). Methodological quality assessment was performed using QUADAS-2 criteria; diagnostic accuracy estimates were stratified by HAI type and key study characteristics. Results 57 studies were included, the majority aiming to detect surgical site or bloodstream infections. Study designs were very diverse regarding the specification of their administrative data algorithm (code selections, follow-up) and definitions of HAI presence. One-third of studies had important methodological limitations including differential or incomplete HAI ascertainment or lack of blinding of assessors. Observed sensitivity and positive predictive values of administrative data algorithms for HAI detection were very heterogeneous and generally modest at best, both for within-hospital algorithms and for formal quality indicators; accuracy was particularly poor for the identification of device-associated HAI such as central line associated bloodstream infections. The large heterogeneity in study designs across the included studies precluded formal calculation of summary diagnostic accuracy estimates in most instances. Conclusions Administrative data had limited and highly variable accuracy for the detection of HAI, and their judicious use for internal surveillance efforts and external quality assessment is recommended. If hospitals and policymakers choose to rely on administrative data for HAI surveillance, continued

  9. A Canadian perspective on the subcutaneous administration of rituximab in non-Hodgkin lymphoma

    PubMed Central

    MacDonald, D.; Crosbie, T.; Christofides, A.; Assaily, W.; Wiernikowski, J.

    2017-01-01

    Rituximab is widely used for the treatment of non-Hodgkin lymphoma, being a key component in most therapeutic regimens. Administration of the intravenous (IV) formulation is lengthy and places a significant burden on health care resources and patient quality of life. A subcutaneous (sc) formulation that provides a fixed dose of rituximab is being examined in a number of studies. Results indicate that the pharmacokinetics are noninferior and response rates are comparable to those obtained with the IV formulation. Moreover, the sc formulation is preferred by patients and health care providers and reduces administration and chair time. Additional advantages include a lesser potential for dosing errors, shorter preparation time, reduced drug wastage, and fewer infusion-related reactions. Despite the success of the sc formulation, correct administration is needed to reduce administration-related reactions. By using a careful procedure, the sc formulation can be given safely and effectively, potentially reducing the burden on health care resources and improving quality of life for patients. PMID:28270723

  10. Bioavailability of cyclophosphamide and vincristine after intraperitoneal administration in cats.

    PubMed

    Voorhorst, Marieke J; van Maarseveen, Erik M; van Lankveld, Adriaan J; Teske, Erik

    2014-11-01

    Cyclophosphamide and vincristine are widely used intravenous chemotherapeutic agents in both human and veterinary oncology. Although intravenous administration of these chemotherapeutics is the gold standard in most treatment protocols, this route of administration has several disadvantages (e.g. long infusion times and risk of extravasation). Therefore, alternative routes have been explored in the past. Recently, good clinical results were achieved with intraperitoneal (i.p.) administration of cyclophosphamide and vincristine in cats. However, the bioavailability following i.p. administration of cyclophosphamide and vincristine providing proof of principle has not been investigated and is the focus of the present study. The pharmacokinetics of cyclophosphamide and vincristine after i.p. and intravenous administration was investigated in six cats in a cross-over study by analysis of plasma levels of cyclophosphamide and vincristine after simultaneously administration of 0.6 mg/m vincristine and 200 mg/m cyclophosphamide. The median bioavailability on i.p. administration was 76% for cyclophosphamide and 100% for vincristine. Median areas under the curve for i.p. and intravenous administration were 11.4 and 16.0 ng h/ml for cyclophosphamide and 16.7 and 16.5 ng h/ml for vincristine, respectively. No specific i.p. administration-related adverse events were observed after i.p. administration. The high bioavailability of both cyclophosphamide and vincristine after i.p. administration and the absence of specific i.p. administration-related side effects suggest that i.p. administration is a suitable route of systemic chemotherapy for both chemotherapeutics. These results are promising and may serve as a stepping stone for the investigation of the pharmacology, safety, and efficacy of i.p. administration of cyclophosphamide and vincristine in humans.

  11. Remote area aboriginal health services managers: key practice challenges.

    PubMed

    Wilson, J

    2001-06-01

    The following reflections on the author's management practice are based on the text of an address given by the author at the 1999 International Conference of the Royal Australasian College of Medical Administrators in Sydney. These reflections arise out of the author's experience for the past 5 years as manager of Nganampa Health Council, an Aboriginal community-controlled health organisation located in the remote north-west of South Australia. Nganampa Health Council is a large regional service with a national reputation for clinical and administrative excellence. It has several leading-edge health programs, which provide an exemplar for other remote health services across Australia. The author discusses three generic key management issues that remote health services managers typically encounter and argues that services are likely to be most effective when resources are applied in a focused and strategic manner and when management practices that are pragmatic and culturally appropriate are adopted.

  12. Reagan Administration Prepares Budget Cuts.

    ERIC Educational Resources Information Center

    Norman, Colin

    1981-01-01

    Describes tentative federal budget cuts affecting science education in the National Science Foundation, National Aeronautics and Space Administration, Department of Energy, National Institutes of Health, and the specific areas these budget cuts will affect. (DS)

  13. Administrative Computing: Ideas That Work.

    ERIC Educational Resources Information Center

    White, Lawrence S.

    1984-01-01

    Describes administrative computer use in the Concord (NH) School District. Applications discussed include procurement, cash flow and investment, accounting and control, and teacher contracts, all performed with in-house programs. (MCG)

  14. Rehabilitation and the Veterans' Administration

    NASA Technical Reports Server (NTRS)

    Meister, F.

    1974-01-01

    The Veteran's Administration health care system provides prosthetic and sensory aids for the rehabilitation of neurologically handicapped veterans. Research and development centers include prosthetic clinic teams, orthopedic shops, restoration clinics, bioengineering services, orthotics, etc.

  15. Attaching Chuck Keys to Machine Tools

    NASA Technical Reports Server (NTRS)

    Richardson, V.

    1984-01-01

    Chuck keys attached to portable machine tools by retracting lanyards. Lanyard held taut by recoil caddy attached to tool base. Chuck key available for use when needed and safely secured during operation of tool.

  16. Iris recognition based on key image feature extraction.

    PubMed

    Ren, X; Tian, Q; Zhang, J; Wu, S; Zeng, Y

    2008-01-01

    In iris recognition, feature extraction can be influenced by factors such as illumination and contrast, and thus the features extracted may be unreliable, which can cause a high rate of false results in iris pattern recognition. In order to obtain stable features, an algorithm was proposed in this paper to extract key features of a pattern from multiple images. The proposed algorithm built an iris feature template by extracting key features and performed iris identity enrolment. Simulation results showed that the selected key features have high recognition accuracy on the CASIA Iris Set, where both contrast and illumination variance exist.

  17. An exploration of administrators' perceptions of elementary science: A case study of the role of science in two elementary schools based on the interactions of administrators with colleagues, science content and state standards

    NASA Astrophysics Data System (ADS)

    Brogdon, Lori-Anne Stelmark

    This research is a case study on the perceptions and attitudes of administrators in the area of elementary science and how their responses reflect agreement or dissonance with the perceptions of elementary teachers on the subject of science within the same district. The study used Likert-type surveys and interviews from both administrators and teachers on five key areas: 1) Attitudes towards science and teaching 2) Attitudes towards teaching science 3) Attitudes towards administrators 4) Time teaching science and 5) Attitudes about policy and standards. Survey data was analyzed within and across areas to identify similarity and difference within each group. The medians from the administrative and teacher surveys were then crossed referenced through the use of a Mann Whitney test to identify areas of similarity. Interview data was coded around three major themes: 1) Standards 2) Classroom Instruction and 3) Conversations. The findings show that even though administrators' perceptions favor the inclusion of science in the elementary classroom, both administrators and teachers in this study reported limited involvement from, and conversation with, each other on the topic of science education. Heavy reliance by the administrators was placed on the use of consultants to provide professional development in the area of science instruction and to review the use of state standards, resulting in limited conversation between administrators and teachers about science. Teachers reported a heavy reliance upon their colleagues in the area of science instruction and curriculum planning. In addition, both administrators and teachers reported a greater focus on math and English for classroom instruction. Findings in this research support implications that more focus should be placed on the role of administrators in the implementation of science instruction. Administrators can play a crucial role in the success of science programs at the building, district and state levels

  18. Locks -- A Key to Violence?

    ERIC Educational Resources Information Center

    Raloff, Janet

    1983-01-01

    New research suggests that personalities prone to extreme violence can be predicted by analysis of chemical elements found in human hair. Methodology employed and results obtained are highlighted and discussed. Relationships between diet and human behavior are also discussed. (JN)

  19. Key participants in codeveloped technology pose for group picture

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Following the presentation of the Universal Signal Conditioning Amplifier (USCA), a new piece of technology developed through a National Aeronautics and Space Administration (NASA) partnership with industry, to Kennedy Space Center (KSC) Director Roy Bridges, Jr., key participants in the partnership pose for a group portrait. They are (from left) Bill Larson, NASA; Dr. Pedro Medelius, INET; Roy Bridges, Jr., KSC Director; Ed Gladney and William Saputo, L-3 Communications; Pam Gillespi, representing Congressman Dave Weldon; and Frank Kinney, Technological Research and Development Authority. The USCA is a key component of the codeveloped Automated Data Acquisition System (ADAS) that measures temperature, pressure and vibration at KSC's launch pads. The breakthrough technology is expected to reduce sensor setup and configuration times from hours to seconds. KSC teamed up with Florida's Technological Research and Development Authority and manufacturer L-3 Communications to produce a system that would benefit the aerospace industry and other commercial markets.

  20. TOLERANCE TO COCAINE’S EFFECTS FOLLOWING CHRONIC ADMINISTRATION OF A DOSE WITHOUT DETECTED EFFECTS ON RESPONSE RATE OR PAUSE

    PubMed Central

    Minervini, Vanessa; Branch, Marc N.

    2014-01-01

    To observe tolerance to drug effects on operant behavior, the dose that researchers have often selected for chronic administration is one that disrupts, but does not abolish, responding. Some evidence suggests that tolerance may develop after chronic administration of relatively smaller doses. The purpose of the present experiment was to assess systematically effects of chronic administration of a dose without detected effect on responding. Specifically, response rates and postreinforcement pauses of five pigeons key pecking under a three-component multiple fixed-ratio schedule of food reinforcement were observed under chronic cocaine administration. We evaluated the effects of a range of doses (1.0 mg/kg to 17.0 mg/kg) during acute administration. The largest dose that failed to alter responding acutely then was administered chronically (1.0 mg/kg for one pigeon, 3.0 mg/kg for three pigeons, and 5.6 mg/kg for one pigeon). After 30 consecutive sessions of chronic administration, smaller and larger doses occasionally were substituted for the chronic dose. Pigeons then received presession saline administration for 30 consecutive sessions, and the postchronic effects of the series of doses on responding were determined. All subjects developed tolerance to doses of cocaine that initially had caused large decreases in rate, with the magnitude of the effects varying across components of the multiple schedule and subjects. Specifically, tolerance generally was greatest in the components with smaller ratios. Following postchronic saline administration, tolerance was usually diminished. Overall, the results demonstrate that under these conditions, repeated experience with disruptive effects of cocaine on food-maintained responding is not a necessary factor in the development of tolerance. PMID:24019029

  1. The Geology of the Florida Keys.

    ERIC Educational Resources Information Center

    Shinn, Eugene A.

    1988-01-01

    Describes some of the ancient geologic history of the Florida Keys from Key Largo to Key West including the effects of glaciers, sea level rise, reef distribution, spurs and grooves, backstepping and ecological zonation, growth rates and erosion. Predicts future changes in this area. (CW)

  2. Harry Potter and the Dichotomous Key

    ERIC Educational Resources Information Center

    Crowther, David T.

    2003-01-01

    In this lesson, students use Bertie Bott's Every Flavor Beans--a "wild" candy written about in the Harry Potter books and now available in stores--to learn about classification and dichotomous keys. In these activities, students sort jelly beans according to a key and then construct a key for a "new" flavor of beans. Students then build on their…

  3. "Key Concepts in ELT": Taking Stock

    ERIC Educational Resources Information Center

    Hall, Graham

    2012-01-01

    This article identifies patterns and trends within "Key Concepts in ELT", both since the inception of the feature in ELT Journal in 1993 and during the 17 years of the current editorship. After outlining the aims of the series, the article identifies key themes that have emerged over time, exploring the links between "Key Concepts" pieces and the…

  4. Practical challenges in quantum key distribution

    DOE PAGES

    Diamanti, Eleni; Lo, Hoi -Kwong; Qi, Bing; ...

    2016-11-08

    Here, quantum key distribution (QKD) promises unconditional security in data communication and is currently being deployed in commercial applications. Nonetheless, before QKD can be widely adopted, it faces a number of important challenges such as secret key rate, distance, size, cost and practical security. Here, we survey those key challenges and the approaches that are currently being taken to address them.

  5. Academic Librarians and Research: A Study of Canadian Library Administrator Perspectives

    ERIC Educational Resources Information Center

    Berg, Selinda Adelle; Jacobs, Heidi L. M.; Cornwall, Dayna

    2013-01-01

    Within the literature exploring the role of research in academic librarianship, very little attention has been paid to the perspectives of upper library administrators. This perspective is critical because library administrators play a key role in hiring, evaluating, supporting, promoting, and tenuring professional librarians. As a way of bringing…

  6. School Administrators' Use of iPads: Impact of Training and Attitudes toward School Use

    ERIC Educational Resources Information Center

    Dogan, Bulent; Almus, Kadir

    2014-01-01

    As Apple iPads are increasingly being adopted in schools for educational purposes, school administrators are seen as the key facilitators in the implementation of this new technology. This survey-based quantitative study investigated the impact of receiving iPad training on school administrators' attitudes towards iPad use in their professional…

  7. Independence day explosion on lovers key.

    PubMed

    Harding, Brett A; Wolf, Barbara C

    2007-09-01

    The display of fireworks is a popular holiday celebration in the United States. Because injuries due to recreational fireworks-related explosions among private consumers are relatively common, the sale of fireworks is regulated by the federal government and is also limited by state and local laws. In contrast, because fireworks display companies are under tight safety regulations, explosions in the professional pyrotechnics industry are uncommon occurrences, and the literature contains rare reports of injuries and fatalities resulting from such explosions. We report the 2003 Fourth of July commercial fireworks explosion on Lovers Key in southwest Florida that resulted in five fatalities. Events occurring during the investigation of the scene of this explosion illustrate the unique considerations and hazards for medicolegal death investigators, law enforcement and other investigative agencies. Additionally, this case demonstrates unusual aspects of the postmortem examinations performed on victims of fireworks-related incidents.

  8. Practical issues in quantum-key-distribution postprocessing

    SciTech Connect

    Fung, C.-H. Fred; Chau, H. F.; Ma Xiongfeng

    2010-01-15

    Quantum key distribution (QKD) is a secure key generation method between two distant parties by wisely exploiting properties of quantum mechanics. In QKD, experimental measurement outcomes on quantum states are transformed by the two parties to a secret key. This transformation is composed of many logical steps (as guided by security proofs), which together will ultimately determine the length of the final secret key and its security. We detail the procedure for performing such classical postprocessing taking into account practical concerns (including the finite-size effect and authentication and encryption for classical communications). This procedure is directly applicable to realistic QKD experiments and thus serves as a recipe that specifies what postprocessing operations are needed and what the security level is for certain lengths of the keys. Our result is applicable to the BB84 protocol with a single or entangled photon source.

  9. Key Gaps for Enabling Plant Growth in Future Missions

    NASA Technical Reports Server (NTRS)

    Anderson, Molly; Motil, Brian; Barta, Dan; Fritsche, Ralph; Massa, Gioia; Quincy, Charlie; Romeyn, Matthew; Wheeler, Ray; Hanford, Anthony

    2017-01-01

    Growing plants to provide food or psychological benefits to crewmembers is a common vision for the future of human spaceflight, often represented in media and in serious concept studies. The complexity of controlled environment agriculture, and plant growth in microgravity have and continue to be the subject of dedicated scientific research. However, actually implementing these systems in a way that will be cost effective, efficient, and sustainable for future space missions is a complex, multi-disciplinary problem. Key questions exist in many areas: human medical research in nutrition and psychology, horticulture, plant physiology and microbiology, multi-phase microgravity fluid physics, hardware design and technology development, and system design, operations and mission planning. This paper describes key knowledge gaps identified by a multi-disciplinary working group within the National Aeronautics and Space Administration (NASA). It also begins to identify solutions to the simpler questions identified by the group based on work initiated in 2017. Growing plants to provide food or psychological benefits to crewmembers is a common vision for the future of human spaceflight, often represented in media and in serious concept studies. The complexity of controlled environment agriculture, and plant growth in microgravity have and continue to be the subject of dedicated scientific research. However, actually implementing these systems in a way that will be cost effective, efficient, and sustainable for future space missions is a complex, multi-disciplinary problem. Key questions exist in many areas: human medical research in nutrition and psychology, horticulture, plant physiology and microbiology, multi-phase microgravity fluid physics, hardware design and technology development, and system design, operations and mission planning. This paper describes key knowledge gaps identified by a multi-disciplinary working group within the National Aeronautics and Space

  10. Small Private Key PKS on an Embedded Microprocessor

    PubMed Central

    Seo, Hwajeong; Kim, Jihyun; Choi, Jongseok; Park, Taehwan; Liu, Zhe; Kim, Howon

    2014-01-01

    Multivariate quadratic ( ) cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011), a small public key scheme, was proposed, and its feasible implementation on an embedded microprocessor was reported at CHES2012. However, the implementation of a small private key scheme was not reported. For efficient implementation, random number generators can contribute to reduce the key size, but the cost of using a random number generator is much more complex than computing on modern microprocessors. Therefore, no feasible results have been reported on embedded microprocessors. In this paper, we propose a feasible implementation on embedded microprocessors for a small private key scheme using a pseudo-random number generator and hash function based on a block-cipher exploiting a hardware Advanced Encryption Standard (AES) accelerator. To speed up the performance, we apply various implementation methods, including parallel computation, on-the-fly computation, optimized logarithm representation, vinegar monomials and assembly programming. The proposed method reduces the private key size by about 99.9% and boosts signature generation and verification by 5.78% and 12.19% than previous results in CHES2012. PMID:24651722

  11. Small private key MQPKS on an embedded microprocessor.

    PubMed

    Seo, Hwajeong; Kim, Jihyun; Choi, Jongseok; Park, Taehwan; Liu, Zhe; Kim, Howon

    2014-03-19

    Multivariate quadratic (MQ) cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to MQ cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011), a small public key MQ scheme, was proposed, and its feasible implementation on an embedded microprocessor was reported at CHES2012. However, the implementation of a small private key MQ scheme was not reported. For efficient implementation, random number generators can contribute to reduce the key size, but the cost of using a random number generator is much more complex than computing MQ on modern microprocessors. Therefore, no feasible results have been reported on embedded microprocessors. In this paper, we propose a feasible implementation on embedded microprocessors for a small private key MQ scheme using a pseudo-random number generator and hash function based on a block-cipher exploiting a hardware Advanced Encryption Standard (AES) accelerator. To speed up the performance, we apply various implementation methods, including parallel computation, on-the-fly computation, optimized logarithm representation, vinegar monomials and assembly programming. The proposed method reduces the private key size by about 99.9% and boosts signature generation and verification by 5.78% and 12.19% than previous results in CHES2012.

  12. Free Energy Landscape - Settlements of Key Residues.

    NASA Astrophysics Data System (ADS)

    Aroutiounian, Svetlana

    2007-03-01

    FEL perspective in studies of protein folding transitions reflects notion that since there are ˜10^N conformations to scan in search of lowest free energy state, random search is beyond biological timescale. Protein folding must follow certain fel pathways and folding kinetics of evolutionary selected proteins dominates kinetic traps. Good model for functional robustness of natural proteins - coarse-grained model protein is not very accurate but affords bringing simulations closer to biological realm; Go-like potential secures the fel funnel shape; biochemical contacts signify the funnel bottleneck. Boltzmann-weighted ensemble of protein conformations and histogram method are used to obtain from MC sampling of protein conformational space the approximate probability distribution. The fel is F(rmsd) = -1/βLn[Hist(rmsd)], β=kBT and rmsd is root-mean-square-deviation from native conformation. The sperm whale myoglobin has rich dynamic behavior, is small and large - on computational scale, has a symmetry in architecture and unusual sextet of residue pairs. Main idea: there is a mathematical relation between protein fel and a key residues set providing stability to folding transition. Is the set evolutionary conserved also for functional reasons? Hypothesis: primary sequence determines the key residues positions conserved as stabilizers and the fel is the battlefield for the folding stability. Preliminary results: primary sequence - not the architecture, is the rule settler, indeed.

  13. SARS: Key factors in crisis management.

    PubMed

    Tseng, Hsin-Chao; Chen, Thai-Form; Chou, Shieu-Ming

    2005-03-01

    This study was conducted at a single hospital selected in Taipei during the SARS (Severe Acute Respiratory Syndrome) outbreak from March to July, 2003 in Taiwan. During this period of time, 104 SARS patients were admitted to the hospital. There were no negative reports related to the selected hospital despite its being located right in the center of an area struck by the epidemic. The purpose of this study was to identify the key factors enabling the hospital to survive SARS unscathed. Data were collected from in-depth interviews with the nursing directors and nursing managers of the SARS units, along with a review of relevant hospital documents. The five key elements identified as survival factors during this SARS crisis are as follows: 1. good control of timing for crisis management, 2. careful decision-making, 3. thorough implementation, 4. effective communication, and 5. trust between management and employees. The results of this study reconfirmed the selected hospital as a model for good crisis management during the SARS epidemic.

  14. Key attributes of expert NRL referees.

    PubMed

    Morris, Gavin; O'Connor, Donna

    2017-05-01

    Experiential knowledge of elite National Rugby League (NRL) referees was investigated to determine the key attributes contributing to expert officiating performance. Fourteen current first-grade NRL referees were asked to identify the key attributes they believed contributed to their expert refereeing performance. The modified Delphi method involved a 3-round process of an initial semi-structured interview followed by 2 questionnaires to reach consensus of opinion. The data revealed 25 attributes that were rated as most important that underpin expert NRL refereeing performance. Results illustrate the significance of the cognitive category, with the top 6 ranked attributes all cognitive skills. Of these, the referees ranked decision-making accuracy as the most important attribute, followed by reading the game, communication, game understanding, game management and knowledge of the rules. Player rapport, positioning and teamwork were the top ranked game skill attributes underpinning performance excellence. Expert referees also highlighted a number of psychological attributes (e.g., concentration, composure and mental toughness) that were significant to performance. There were only 2 physiological attributes (fitness, aerobic endurance) that were identified as significant to elite officiating performance. In summary, expert consensus was attained which successfully provided a hierarchy of the most significant attributes of expert NRL refereeing performance.

  15. The Key to Custom Training.

    ERIC Educational Resources Information Center

    Schapiro, Dennis

    1985-01-01

    Takes a look at the questions involved in designing customized training: What changes does management expect to see as the result of training? Who has information that must be included and excluded? How "customized" should the training be? and How will the training be delivered? (CT)

  16. Nurses' perceptions of administrative social support.

    PubMed

    Ihlenfeld, J T

    1996-01-01

    A meta-analysis of 125 nurses in three types of nursing roles investigated whether these nurses received social support from their administrators, the types of social support received, and whether more or less social support from these managers was desired. The Arizona Social Support Interview Schedule (ASSIS) was used to assess these questions. Results showed that home health nurses received social participation and physical assistance, whereas staff nurses received positive feedback and physical assistance. Nursing faculty received little support from their managers. Social exchange theory predicts that intangibles such as social support should exist in equitable relationships. It is possible that the difference in the nurses' and administrators' statuses and power levels affected staff nurses' results. Mental health clinical nurse specialists can use these results to help nurses understand their work relationships.

  17. Cuesta College School Performance Results.

    ERIC Educational Resources Information Center

    Cuesta Coll., San Luis Obispo, CA.

    This Cuesta College (California) document identifies key institutional effectiveness indicators that are used to assess institutional performance on specified educational processes. The key process of instruction/learning is measured through student performance results such as: (1) transfer rate (University of California/California State…

  18. A Study on the Single-dose Oral Toxicity of Super Key in Sprague-Dawley Rats

    PubMed Central

    Kim, Jinhee; Lee, Jongcheol; Kim, Sungchul

    2015-01-01

    Objectives: This study was performed to analyze the single-dose oral toxicity of the super key (processed sulfur). Methods: All experiments were conducted at Medvill, an institution authorized to perform non-clinical studies, under the Good Laboratory Practice (GLP) regulations. In order to investigate the oral toxicity of super key We administered it orally to Sprague-Dawley (SD) rats. The SD rats were divided into four groups of five male and five female animals per group: group 1 being the control group and groups 2, 3, and 4 being the experimental groups. Doses of super key 500 mg/kg, 1,000 mg/kg and 2,000 mg/kg were administered to the experimental groups, and a dose of normal saline solution, 10 mL/kg, was administered to the control group. We examined the survival rates, weights, clinical signs, gross findings and necropsy findings. This study was conducted under the approval of the Institutional Animal Ethics Committee. (Approval number: A01-14018). Results: No deaths or abnormalities occurred in any of the four groups. Although slight decreases in the weights of some female rats were noted, no significant changes in weights or differences in the gross findings between the control group and the experimental groups were observed. To check for abnormalities in organs, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs. Conclusion: The results of this research showed that administration of 500 ─ 2,000 mg/kg of super key did not cause any changes in the weights or in the results of necropsy examinations. Neither did it result in any mortalities. The above findings suggest that treatment with super key is relatively safe. Further studies on this subject are needed to yield more concrete evidence. PMID:26392913

  19. Key Stakeholders' Perceptions of Motivators for Research Participation Among Individuals Who Are Incarcerated.

    PubMed

    Hanson, Bridget L; Faulkner, Sherilyn A; Brems, Christiane; Corey, Staci L; Eldridge, Gloria D; Johnson, Mark E

    2015-10-01

    Understanding motivations of research participants is crucial for developing ethical research protocols, especially for research with vulnerable populations. Through interviews with 92 institutional review board members, prison administrators, research ethicists, and researchers, we explored key stakeholders' perceptions of what motivates incarcerated individuals to participate in research. Primary motivators identified were a desire to contribute to society, gaining knowledge and health care, acquiring incentives, and obtaining social support. The potential for undue influence or coercion were also identified as motivators. These results highlight the need for careful analysis of what motivates incarcerated individuals to participate in research as part of developing or reviewing ethically permissible and responsible research protocols. Future research should expand this line of inquiry to directly include perspectives of incarcerated individuals.

  20. Key Stakeholders’ Perceptions of Motivators for Research Participation among Individuals who are Incarcerated

    PubMed Central

    Hanson, Bridget L.; Faulkner, Sherilyn A.; Brems, Christiane; Corey, Staci L.; Eldridge, Gloria D.; Johnson, Mark E.

    2015-01-01

    Understanding motivations of research participants is crucial for developing ethical research protocols, especially for research with vulnerable populations. Through interviews with 92 IRB members, prison administrators, research ethicists, and researchers, we explored key stakeholders’ perceptions of what motivates incarcerated individuals to participate in research. Primary motivators identified were a desire to contribute to society, gaining knowledge and healthcare, acquiring incentives, and obtaining social support. The potential for undue influence or coercion were also identified as motivators. These results highlight the need for careful analysis of what motivates incarcerated individuals to participate in research as part of developing or reviewing ethically permissible and responsible research protocols. Future research should expand this line of inquiry to directly include perspectives of incarcerated individuals. PMID:26283681