49 CFR 236.745 - Face, locking.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 4 2012-10-01 2012-10-01 false Face, locking. 236.745 Section 236.745 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Face, locking. The locking surface of a locking dog, tappet or cross locking of an interlocking machine. ...

49 CFR 236.745 - Face, locking.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Face, locking. 236.745 Section 236.745 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Face, locking. The locking surface of a locking dog, tappet or cross locking of an interlocking machine. ...

49 CFR 236.745 - Face, locking.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 4 2013-10-01 2013-10-01 false Face, locking. 236.745 Section 236.745 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Face, locking. The locking surface of a locking dog, tappet or cross locking of an interlocking machine. ...

New Tool for Benefit-Cost Analysis in Evaluating Transportation Alternatives

DOT National Transportation Integrated Search

1997-01-01

The Intermodal Surface Transportation Efficiency Act (ISTEA) emphasizes assessment of multi-modal alternatives and demand management strategies. In 1995, the Federal Highway Administration (FHWA) developed a corridor sketch planning tool called the S...

75 FR 54421 - Sixth Meeting: RTCA Special Committee 223: Airport Surface Wireless Communications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-07

... 223: Airport Surface Wireless Communications AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 223: Airport Surface Wireless... Committee 223: Airport Surface Wireless Communications. DATES: The meeting will be held September 28-30...

76 FR 6179 - Eighth Meeting: RTCA Special Committee 223: Airport Surface Wireless Communications

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... Committee 223: Airport Surface Wireless Communications AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 223: Airport Surface Wireless... Committee 223: Airport Surface Wireless Communications. DATES: The meeting will be held February 22-23, 2011...

75 FR 66423 - Seventh Meeting: RTCA Special Committee 223: Airport Surface Wireless Communications

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-28

... Committee 223: Airport Surface Wireless Communications AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 223: Airport Surface Wireless... Committee 223: Airport Surface Wireless Communications. DATES: The meeting will be held November 16-17, 2010...

78 FR 33145 - Meeting: RTCA Special Committee 223, Airport Surface Wireless Communications

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-03

..., Airport Surface Wireless Communications AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Meeting Notice of RTCA Special Committee 223, Airport Surface Wireless... Committee 223, Airport Surface Wireless Communications. DATES: The meeting will be held June 26-28, 2013...

Road weather management program performance metrics : implementation and assessment.

DOT National Transportation Integrated Search

2009-08-31

Since the late 1990s, the U.S. Department of Transportation (USDOT), Federal Highway Administration (FHWA) has managed a program dedicated to improving the safety, mobility and productivity of the nations surface transportation modes by integra...

Transportation, environmental justice, and social equity conference proceedings

DOT National Transportation Integrated Search

1995-07-01

The purpose of the conference was to bring forth issues and begin a dialogue between those affected and those responsible for meeting transportation challenges. The conference was sponsored by the Federal Transit Administration (FTA) and Surface Tran...

Friction management on Kansas Department of Transportation highways.

DOT National Transportation Integrated Search

2017-04-01

The Federal Highway Administration (FHWA) estimates that about 70% of wet pavement crashes can be : prevented or minimized by improving pavement friction. High Friction Surface Treatment (HFST), a speciallydesigned : thin surface application of hard ...

14 CFR 77.28 - Military airport imaginary surfaces.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Military airport imaginary surfaces. 77.28 Section 77.28 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... above the established airfield elevation. (3) Outer horizontal surface. A plane, located 500 feet above...

Lateral attenuation of aircraft sound levels over an acoustically hard water surface : Logan Airport study

DOT National Transportation Integrated Search

2000-05-01

The National Aeronautics and Space Administration (NASA), Langley Research Center (LaRC), sponsored the Acoustics Facility at the United States Department of Transportation's John A. Volpe National Transportation Systems Center (Volpe Center) and the...

14 CFR 25.655 - Installation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Installation. 25.655 Section 25.655 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Control Surfaces § 25.655 Installation. (a...

14 CFR 25.655 - Installation.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Installation. 25.655 Section 25.655 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Control Surfaces § 25.655 Installation. (a...

14 CFR 25.655 - Installation.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Installation. 25.655 Section 25.655 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Control Surfaces § 25.655 Installation. (a...

14 CFR 25.655 - Installation.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Installation. 25.655 Section 25.655 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY AIRPLANES Design and Construction Control Surfaces § 25.655 Installation. (a...

Evaluation of high friction surface locations in Kansas.

DOT National Transportation Integrated Search

2016-05-01

In 2009, the Kansas Department of Transportation entered into an agreement with the Federal Highway : Administration to fulfill the requirements of the High Friction Surface Materials Enhancing Safety at Horizontal : Curves on the National Highway Sy...

Benefit-cost assessment of a maintenance decision support system (MDSS) implementation : the city and county of Denver.

DOT National Transportation Integrated Search

2009-12-07

The Federal Highway Administration, U.S. Department of Transportation, has established a Road Weather Management Program (RWMP) that seeks to improve the safety, mobility and productivity of the nations surface transportation modes by integrating ...

23 CFR 658.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-04-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS TRUCK SIZE AND WEIGHT, ROUTE DESIGNATIONS-LENGTH, WIDTH AND WEIGHT LIMITATIONS § 658.1 Purpose. The purpose of this part is to identify a National Network of highways available to vehicles authorized by provisions of the Surface Transportation...

Evaluation of high friction surface locations in Kansas : technical summary.

DOT National Transportation Integrated Search

2016-05-01

In 2009, the Kansas Department of Transportation entered into an agreement with the Federal Highway Administration to fulfill the requirements of the High Friction Surface Materials Enhancing Safety at Horizontal Curves on the National Highway System...

23 CFR 656.3 - Policy.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Policy. 656.3 Section 656.3 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CARPOOL AND VANPOOL PROJECTS § 656.3 Policy. Section 126(d) of the Surface Transportation Assistance Act of 1978 declares that...

23 CFR 656.3 - Policy.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Policy. 656.3 Section 656.3 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CARPOOL AND VANPOOL PROJECTS § 656.3 Policy. Section 126(d) of the Surface Transportation Assistance Act of 1978 declares that...

23 CFR 656.3 - Policy.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Policy. 656.3 Section 656.3 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CARPOOL AND VANPOOL PROJECTS § 656.3 Policy. Section 126(d) of the Surface Transportation Assistance Act of 1978 declares that...

23 CFR 656.3 - Policy.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Policy. 656.3 Section 656.3 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CARPOOL AND VANPOOL PROJECTS § 656.3 Policy. Section 126(d) of the Surface Transportation Assistance Act of 1978 declares that...

23 CFR 656.3 - Policy.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Policy. 656.3 Section 656.3 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS CARPOOL AND VANPOOL PROJECTS § 656.3 Policy. Section 126(d) of the Surface Transportation Assistance Act of 1978 declares that...

Final report of the evaluation of the FORETELL consortium operational test : weather information for surface transportation

DOT National Transportation Integrated Search

2003-04-01

Over 17 percent of all fatal crashes occur during winter weather conditions. Of those, 60 percent happen in rural areas (most on non-interstate roadways). The Federal Highway Administration (FHWA) Intelligent Transportation System (ITS) Joint Program...

Implementation of the National Intelligent Transportation Systems Program : 1997 report to Congress

DOT National Transportation Integrated Search

2000-07-01

This report is the first biennial report on the status of the Federal Highway Administration's (FHWA) Value Pricing Pilot Program as required by the Intermodal Surface Transportation Efficiency Act of 1991, Section 1012(b)(5). It follows an iterim le...

23 CFR 180.1 - Cross-reference to credit assistance.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Cross-reference to credit assistance. 180.1 Section 180.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 180.1 Cross-reference to credit assistance. The regulations...

23 CFR 180.1 - Cross-reference to credit assistance.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Cross-reference to credit assistance. 180.1 Section 180.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 180.1 Cross-reference to credit assistance. The regulations...

23 CFR 180.1 - Cross-reference to credit assistance.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Cross-reference to credit assistance. 180.1 Section 180.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 180.1 Cross-reference to credit assistance. The regulations...

23 CFR 180.1 - Cross-reference to credit assistance.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Cross-reference to credit assistance. 180.1 Section 180.1 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES CREDIT ASSISTANCE FOR SURFACE TRANSPORTATION PROJECTS § 180.1 Cross-reference to credit assistance. The regulations...

30 CFR 77.1905 - Hoist safeguards; general.

Code of Federal Regulations, 2010 CFR

2010-07-01

....1905 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS, SURFACE COAL MINES AND SURFACE WORK AREAS OF UNDERGROUND COAL MINES... when fully loaded. (b) When persons are transported by a hoist, a second person familiar with and...

14 CFR 23.397 - Limit control forces and -torques.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Limit control forces and -torques. 23.397 Section 23.397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Control Surface and System Loads § 23.397 Limit control forces and -torques. (a) In the control surface...

14 CFR 23.397 - Limit control forces and -torques.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Limit control forces and -torques. 23.397 Section 23.397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Control Surface and System Loads § 23.397 Limit control forces and -torques. (a) In the control surface...

14 CFR 23.397 - Limit control forces and -torques.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Limit control forces and -torques. 23.397 Section 23.397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Control Surface and System Loads § 23.397 Limit control forces and -torques. (a) In the control surface...

14 CFR 23.397 - Limit control forces and -torques.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Limit control forces and -torques. 23.397 Section 23.397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Control Surface and System Loads § 23.397 Limit control forces and -torques. (a) In the control surface...

14 CFR 23.397 - Limit control forces and -torques.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Limit control forces and -torques. 23.397 Section 23.397 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... Control Surface and System Loads § 23.397 Limit control forces and -torques. (a) In the control surface...

14 CFR 23.393 - Loads parallel to hinge line.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) K=24 for vertical surfaces; (2) K=12 for horizontal surfaces; and (3) W=weight of the movable... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Loads parallel to hinge line. 23.393 Section 23.393 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

14 CFR 23.393 - Loads parallel to hinge line.

Code of Federal Regulations, 2013 CFR

2013-01-01

...) K=24 for vertical surfaces; (2) K=12 for horizontal surfaces; and (3) W=weight of the movable... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Loads parallel to hinge line. 23.393 Section 23.393 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

14 CFR 23.393 - Loads parallel to hinge line.

Code of Federal Regulations, 2014 CFR

2014-01-01

...) K=24 for vertical surfaces; (2) K=12 for horizontal surfaces; and (3) W=weight of the movable... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Loads parallel to hinge line. 23.393 Section 23.393 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

14 CFR 23.393 - Loads parallel to hinge line.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) K=24 for vertical surfaces; (2) K=12 for horizontal surfaces; and (3) W=weight of the movable... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Loads parallel to hinge line. 23.393 Section 23.393 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

14 CFR 23.393 - Loads parallel to hinge line.

Code of Federal Regulations, 2010 CFR

2010-01-01

...) K=24 for vertical surfaces; (2) K=12 for horizontal surfaces; and (3) W=weight of the movable... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Loads parallel to hinge line. 23.393 Section 23.393 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

Overview and application of the Continuous-Flow Traffic Time-Integrated Method (CTIM) for determining the influence of road surfaces on traffic noise

DOT National Transportation Integrated Search

2012-08-19

The U.S. Department of Transportation Federal Highway Administration is sponsoring a Technical Working Group (TWG) to develop guidance for measuring the influence of road surfaces on tire-pavement noise, vehicle noise, and traffic noise in the U.S. T...

Bus Testing Program

DOT National Transportation Integrated Search

1993-01-01

The Bus Testing Program of the Federal Transit Administration was established in response to the requirements of the Surface Transportation and Uniform Relocation Assistance Act (STURAA) of 1987. Under the program, testing is required on all new mode...

Expert systems for crash data collection

DOT National Transportation Integrated Search

1995-08-01

The Federal Highway Administration (FHWA) recognizes that many metropolitan areas are struggling with how to respond adequately to the 1990 Clean Air Act Amendments (CAAA) and the 1991 Intermodal Surface Transportation Efficiency Act (ISTEA), particu...

Storage and transport of reconstituted omacetaxine mepesuccinate: Considerations for home administration.

PubMed

Parikh, Alpa; van de Rijn, Jennifer; Melville, Chris; Sarkari, Marazban; Peltier, Sylvie; McKean, Robert

2018-04-01

Purpose Omacetaxine mepesuccinate ("omacetaxine") is approved by the US Food and Drug Administration for the treatment of adult patients with chronic- or accelerated-phase chronic myeloid leukemia with resistance and/or intolerance to two or more tyrosine kinase inhibitors. In May 2014, the US Food and Drug Administration approved revisions to the packaging information that included directions for home administration of reconstituted omacetaxine by patients or caregivers using syringes filled at a healthcare facility. We developed recommendations for the transport, storage, and spill-clean procedure of reconstituted omacetaxine for home and clinic administration. Methods We conducted chemical stability and microbial growth studies of reconstituted omacetaxine solution stored in vials and syringes at room temperature or refrigerated for various durations. Several shipping configurations were tested in simulated transport conditions to evaluate their ability to contain solution leakage and maintain product quality during distribution. In addition, we evaluated cleaning products and procedures for their effectiveness in removing residual omacetaxine from household surfaces after mock spills. Results Reconstituted omacetaxine showed limited degradation when refrigerated for 14 days in vials and syringes, and no microbial growth was observed for 12 days after intentional inoculation. In shipping studies, the configurations maintained prepared syringes within the recommended storage temperature range throughout transport and could contain leaks if spills occurred. In the event of an accidental spill in a home environment, effective cleaning can be achieved using household cleaning products and defined procedures. Conclusion These data provide important information regarding the safe transportation and administration of reconstituted omacetaxine in the home and clinic.

30 CFR 36.48 - Tests of surface temperature of engine and components of the cooling system.

Code of Federal Regulations, 2011 CFR

2011-07-01

... with the engine operated as prescribed by MSHA. All parts of the engine, cooling system, and other... components of the cooling system. 36.48 Section 36.48 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... PERMISSIBLE MOBILE DIESEL-POWERED TRANSPORTATION EQUIPMENT Test Requirements § 36.48 Tests of surface...

30 CFR 36.48 - Tests of surface temperature of engine and components of the cooling system.

Code of Federal Regulations, 2010 CFR

2010-07-01

... with the engine operated as prescribed by MSHA. All parts of the engine, cooling system, and other... components of the cooling system. 36.48 Section 36.48 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION... PERMISSIBLE MOBILE DIESEL-POWERED TRANSPORTATION EQUIPMENT Test Requirements § 36.48 Tests of surface...

49 CFR 1243.3 - Report of fuel cost, consumption, and surcharge revenue.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., Environmental Analysis, and Administration, Surface Transportation Board, Washington, DC 20423-0001, within 30... published on the Board's website and is maintained by the agency for at least 2 years. The display of a...

49 CFR 1243.3 - Report of fuel cost, consumption, and surcharge revenue.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., Environmental Analysis, and Administration, Surface Transportation Board, Washington, DC 20423-0001, within 30... published on the Board's website and is maintained by the agency for at least 2 years. The display of a...

14 CFR 29.307 - Proof of structure.

Code of Federal Regulations, 2011 CFR

2011-01-01

... system, including control surfaces; (3) Operation tests of the control system; (4) Flight stress... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... loading condition accounting for the environment to which the structure will be exposed in operation...

14 CFR 27.307 - Proof of structure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... system, including control surfaces; (3) Operation tests of the control system; (4) Flight stress... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... loading condition accounting for the environment to which the structure will be exposed in operation...

14 CFR 27.307 - Proof of structure.

Code of Federal Regulations, 2013 CFR

2013-01-01

... system, including control surfaces; (3) Operation tests of the control system; (4) Flight stress... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... loading condition accounting for the environment to which the structure will be exposed in operation...

14 CFR 29.307 - Proof of structure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... system, including control surfaces; (3) Operation tests of the control system; (4) Flight stress... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... loading condition accounting for the environment to which the structure will be exposed in operation...

14 CFR 29.307 - Proof of structure.

Code of Federal Regulations, 2013 CFR

2013-01-01

... system, including control surfaces; (3) Operation tests of the control system; (4) Flight stress... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... loading condition accounting for the environment to which the structure will be exposed in operation...

14 CFR 27.307 - Proof of structure.

Code of Federal Regulations, 2014 CFR

2014-01-01

... system, including control surfaces; (3) Operation tests of the control system; (4) Flight stress... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... loading condition accounting for the environment to which the structure will be exposed in operation...

14 CFR 27.307 - Proof of structure.

Code of Federal Regulations, 2011 CFR

2011-01-01

... system, including control surfaces; (3) Operation tests of the control system; (4) Flight stress... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... loading condition accounting for the environment to which the structure will be exposed in operation...

14 CFR 29.307 - Proof of structure.

Code of Federal Regulations, 2012 CFR

2012-01-01

... system, including control surfaces; (3) Operation tests of the control system; (4) Flight stress... Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... loading condition accounting for the environment to which the structure will be exposed in operation...

Effective implementation of GPR for condition assessment and monitoring - Phase 2.

DOT National Transportation Integrated Search

2016-10-01

The Maryland Department of Transportation State Highway Administration (SHA) is currently using Ground : Penetrating Radar (GPR) for assessing the condition of bridge decks (such as surface condition, rebar cover depth : and location, and deck thickn...

Benefits of Safety Belts and Motorcycle Helmets. Report to Congress

DOT National Transportation Integrated Search

1996-02-01

This study was undertaken in response to Section 1031(b) of the Intermodal : Surface Transportation Efficiency Act of 1991 (ISTEA), which required the : National Highway Traffic Safety Administration (NHTSA) to conduct a study to : determine the bene...

49 CFR 1.82 - The Federal Aviation Administration.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., with due consideration of safety, capacity, efficiency, environmental compatibility and sustainability... connections to surface transportation, and other efforts to increase the environmental sustainability of the... improve airport safety, efficiency, and sustainability; (13) Exercising the final authority for carrying...

49 CFR 1.82 - The Federal Aviation Administration.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., with due consideration of safety, capacity, efficiency, environmental compatibility and sustainability... connections to surface transportation, and other efforts to increase the environmental sustainability of the... improve airport safety, efficiency, and sustainability; (13) Exercising the final authority for carrying...

49 CFR 1.82 - The Federal Aviation Administration.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., with due consideration of safety, capacity, efficiency, environmental compatibility and sustainability... connections to surface transportation, and other efforts to increase the environmental sustainability of the... improve airport safety, efficiency, and sustainability; (13) Exercising the final authority for carrying...

Rail fixed guideway systems : state safety oversight : final rule

DOT National Transportation Integrated Search

1995-12-27

As required by the Intermodal Surface Transportation Efficiency Act of 1991, the Federal Transit Administration (FTA) issues a rule requiring states to oversee the safety of rail fixed guideway systems not regulated by the Federal Railroad Administra...

Consideration of the 15 Factors in the Metropolitan Planning Process

DOT National Transportation Integrated Search

1995-01-01

This synthesis will be of immediate interest to land luse and transportation : planning officials, with special interest to state, regional, and local planners : and administrators who must repond to the requirements of the Intermodal Surface : Trans...

Coal Transportation Rate Sensitivity Analysis

EIA Publications

2005-01-01

On December 21, 2004, the Surface Transportation Board (STB) requested that the Energy Information Administration (EIA) analyze the impact of changes in coal transportation rates on projected levels of electric power sector energy use and emissions. Specifically, the STB requested an analysis of changes in national and regional coal consumption and emissions resulting from adjustments in railroad transportation rates for Wyoming's Powder River Basin (PRB) coal using the National Energy Modeling System (NEMS). However, because NEMS operates at a relatively aggregate regional level and does not represent the costs of transporting coal over specific rail lines, this analysis reports on the impacts of interregional changes in transportation rates from those used in the Annual Energy Outlook 2005 (AEO2005) reference case.

Effective implementation of GPR for condition assessment and monitoring - phase 2 : final report.

DOT National Transportation Integrated Search

2016-10-01

The Maryland Department of Transportation State Highway Administration (SHA) is currently using Ground Penetrating Radar (GPR) for assessing the condition of bridge decks (such as surface condition, rebar cover depth and location, and deck thickness)...

Durability of truncated dome warnings on existing curb ramps : final report.

DOT National Transportation Integrated Search

2004-12-01

In 2002 the Federal Highway Administration (FHWA) notified the Oregon Department of Transportation (ODOT) that that the state was required to use truncated dome detectable warnings on curb ramps. Products appropriate for use on cured concrete surface...

Adolescent Atomoxetine Treatment in a Rodent Model of ADHD: Effects on Cocaine Self-Administration and Dopamine Transporters in Frontostriatal Regions

PubMed Central

Somkuwar, Sucharita S; Jordan, Chloe J; Kantak, Kathleen M; Dwoskin, Linda P

2013-01-01

Cocaine abuse and attention deficit/hyperactivity disorder (ADHD) are often comorbid. Preclinical research indicates that medial prefrontal (mPFC) and orbitofrontal (OFC) cortices are important neural substrates for both disorders. Using the spontaneously hypertensive rat (SHR) model of ADHD, we reported that adolescent treatment with the stimulant methylphenidate, a dopamine (DAT) and norepinephrine (NET) transporter inhibitor, enhanced cocaine self-administration during adulthood, and was associated with increased DAT function in mPFC. This study investigates the effects of atomoxetine ((R)-N-methyl-γ-(2-methylphenoxy)-benzenepropanamine hydrochloride) treatment, a selective NET inhibitor, during adolescence on cocaine self-administration and on DAT function and cell-surface expression in mPFC and OFC during adulthood. SHR acquired cocaine self-administration faster than Wistar–Kyoto and Wistar. Across cocaine doses, SHR earned more cocaine infusions and had higher progressive-ratio breakpoints than Wistar–Kyoto and Wistar, demonstrating that the SHR phenotype models comorbid ADHD and cocaine abuse. Prior atomoxetine treatment did not augment cocaine self-administration in SHR, but acquisition was enhanced in Wistar–Kyoto. No strain differences were found for DAT kinetic parameters or cellular localization in the vehicle controls. Atomoxetine did not alter DAT kinetic parameters or localization in SHR mPFC. Rather, atomoxetine decreased Vmax and DAT cell surface expression in SHR OFC, indicating that inhibition of NET by atomoxetine treatment during adolescence indirectly reduced DAT function and trafficking to the cell surface in OFC, specifically in the ADHD model. Thus, atomoxetine, unlike methylphenidate, does not enhance vulnerability to cocaine abuse in SHR and may represent an important alternative for teens with ADHD when drug addiction is a concern. PMID:23822950

14 CFR 27.427 - Unsymmetrical loads.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Unsymmetrical loads. 27.427 Section 27.427 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Strength Requirements Control Surface and System Loads § 27.427...

30 CFR 57.6312 - Secondary blasting.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-UNDERGROUND METAL AND NONMETAL MINES Explosives Transportation-Surface and Underground § 57.6312 Secondary blasting. Secondary blasts fired at the same time in...

30 CFR 57.6308 - Initiation systems.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Initiation systems. 57.6308 Section 57.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Transportation-Surface and Underground § 57.6308 Initiation systems. Initiation systems shall be used in...

30 CFR 57.6308 - Initiation systems.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Initiation systems. 57.6308 Section 57.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Transportation-Surface and Underground § 57.6308 Initiation systems. Initiation systems shall be used in...

30 CFR 57.6308 - Initiation systems.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Initiation systems. 57.6308 Section 57.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Transportation-Surface and Underground § 57.6308 Initiation systems. Initiation systems shall be used in...

30 CFR 56.19096 - Familiarity with signal code.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 56.19096 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Personnel... signals for cages, skips, and mantrips when persons or materials are being transported shall be familiar...

14 CFR 23.659 - Mass balance.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Mass balance. 23.659 Section 23.659 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Surfaces § 23.659 Mass balance. The supporting structure and the attachment of concentrated mass balance...

14 CFR 23.659 - Mass balance.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Mass balance. 23.659 Section 23.659 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... Surfaces § 23.659 Mass balance. The supporting structure and the attachment of concentrated mass balance...

14 CFR 139.307 - Unpaved areas.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Unpaved areas. 139.307 Section 139.307 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... causing damage to an aircraft. (5) Debris and foreign objects must be promptly removed from the surface...

14 CFR 139.307 - Unpaved areas.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Unpaved areas. 139.307 Section 139.307 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... causing damage to an aircraft. (5) Debris and foreign objects must be promptly removed from the surface...

49 CFR 1014.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE SURFACE TRANSPORTATION BOARD... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... activity or in undue financial and administrative burdens. In those circumstances where agency personnel...

Final Research Report: Administrative and Legal Issues Associated with a Multi-State VMT-Based Charge System

DOT National Transportation Integrated Search

2010-11-01

In May 2009, the I-95 Coalition convened a workshop of experts to discuss how the Coalition could best contribute to the national dialogue regarding VMT-based charge systems. Following the recommendations of the National Surface Transportation Policy...

14 CFR 139.307 - Unpaved areas.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Unpaved areas. 139.307 Section 139.307 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... causing damage to an aircraft. (5) Debris and foreign objects must be promptly removed from the surface...

14 CFR 139.307 - Unpaved areas.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Unpaved areas. 139.307 Section 139.307 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... causing damage to an aircraft. (5) Debris and foreign objects must be promptly removed from the surface...

14 CFR 139.307 - Unpaved areas.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Unpaved areas. 139.307 Section 139.307 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... causing damage to an aircraft. (5) Debris and foreign objects must be promptly removed from the surface...

14 CFR 73.3 - Special use airspace.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Special use airspace. 73.3 Section 73.3 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE... defined dimensions identified by an area on the surface of the earth wherein activities must be confined...

14 CFR 23.445 - Outboard fins or winglets.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Outboard fins or winglets. 23.445 Section 23.445 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... with loads induced by the fins or winglets and moments or forces exerted on the horizontal surfaces or...

14 CFR 23.445 - Outboard fins or winglets.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Outboard fins or winglets. 23.445 Section 23.445 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT... with loads induced by the fins or winglets and moments or forces exerted on the horizontal surfaces or...

30 CFR 57.6309 - Fuel oil requirements for ANFO.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Fuel oil requirements for ANFO. 57.6309 Section 57.6309 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... Transportation-Surface and Underground § 57.6309 Fuel oil requirements for ANFO. (a) Liquid hydrocarbon fuels...

30 CFR 57.6309 - Fuel oil requirements for ANFO.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Fuel oil requirements for ANFO. 57.6309 Section 57.6309 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... Transportation-Surface and Underground § 57.6309 Fuel oil requirements for ANFO. (a) Liquid hydrocarbon fuels...

30 CFR 56.4100 - Smoking and use of open flames.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 56.4100 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE SAFETY AND HEALTH SAFETY AND HEALTH STANDARDS-SURFACE METAL AND NONMETAL MINES Fire... flammable gases are— (a) Used or transported in a manner that could create a fire hazard; or (b) Stored or...

14 CFR 71.71 - Class E airspace.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Class E airspace. 71.71 Section 71.71 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRSPACE... (2) The airspace below 1,500 feet above the surface of the earth. (b) The airspace areas designated...

14 CFR 137.37 - Manner of dispensing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Manner of dispensing. 137.37 Section 137.37 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... aircraft, any material or substance in a manner that creates a hazard to persons or property on the surface...

14 CFR 137.37 - Manner of dispensing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Manner of dispensing. 137.37 Section 137.37 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... aircraft, any material or substance in a manner that creates a hazard to persons or property on the surface...

14 CFR 137.37 - Manner of dispensing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Manner of dispensing. 137.37 Section 137.37 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... aircraft, any material or substance in a manner that creates a hazard to persons or property on the surface...

14 CFR 137.37 - Manner of dispensing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Manner of dispensing. 137.37 Section 137.37 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS... aircraft, any material or substance in a manner that creates a hazard to persons or property on the surface...

30 CFR 57.6304 - Primer protection.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Primer protection. 57.6304 Section 57.6304 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Transportation-Surface and Underground § 57.6304 Primer protection. (a) Tamping shall not be done directly on a...

49 CFR 238.435 - Interior fittings and surfaces.

Code of Federal Regulations, 2010 CFR

2010-10-01

... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PASSENGER EQUIPMENT SAFETY STANDARDS Specific Requirements for Tier... sufficient to withstand the following individually applied accelerations acting on the mass of the seat plus the mass of a seat occupant who is a 95th-percentile adult male: (1) Lateral: 4g; and (2) Vertical: 4g...

ACHP | News | Federal Highway Administration wins Chairman's Award for

Science.gov Websites

major source of federal funding for local and state historic preservation efforts." The award was Intermodal Surface Transportation Efficiency Act began to find an appropriate balance by creating and funding largest single source of federal funding for historic preservation. The funding is provided through a

Comparative safety assessment of surface versus submarine plutonium shipments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Knepper, D.S.; Feltus, M.A.

1993-01-01

The recent shipment of plutonium from France to Japan aboard the freighter Akatsuki Maru touched off protests from environmental and antinuclear organizations. These protests arose from the fear of an accidental sinking of the vessel that would release its cargo to the sea, as well as the threat of a terrorist nation highjacking the ship for its cargo to produce atomic weapons. The sinking of a merchant ship is not uncommon, as illustrated by the famous losses of the tankers Amoco Cadiz and Exxon Valdez. The highjacking of a lightly armed freighter such as the Akatsuki Maru is possible andmore » would not be unduly difficult for a well-equipped terrorist nation. The combined threats of weapons proliferation and environmental damage arising from the diversion or destruction of a sea vessel carrying plutonium will continue to abound as the reprocessing of spent nuclear fuel increases. An alternate method for the transportation with reduced risks of both diversion and destruction needs to be developed. The shipment aboard the Akatsuki Maru was originally proposed to be flown from France to Japan over the continental United States. This proposal was rejected by the Reagan administration in 1988. A third alternative to the current ideas of air transport and surface transport is subsurface transport. This research project investigates the transportation of plutonium by submarine and compares it to the current method of transportation by freighter. This analysis involves a study of the military threat to a submarine by a terrorist nation and comparable threat to a surface vessel. To study the nonmilitary aspects of plutonium shipping, a fault-tree evaluation is performed for transportation by submarine and compared with the current risk analysis performed for surface vessels.« less

49 CFR 510.6 - Administrative depositions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Administrative depositions. 510.6 Section 510.6 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMATION GATHERING POWERS § 510.6 Administrative depositions. (a...

75 FR 47736 - Amendment of Class D and E Airspace, Establishment of Class E Airspace; Patuxent River, MD

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-09

... Air Station (NAS), Patuxent River, MD, to reflect the part-time operating status of the control tower... extension to Class D surface area at Patuxent River NAS, Patuxent River, MD, to reflect the part-time... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 71 [Docket No. FAA-2010...

49 CFR 1503.203 - Investigations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... Chief Counsel, the Assistant Administrator for Security Operations, the Assistant Administrator for...

Synaptic Glutamate Spillover Due to Impaired Glutamate Uptake Mediates Heroin Relapse

PubMed Central

Scofield, Michael D.; Boger, Heather; Hensley, Megan; Kalivas, Peter W.

2014-01-01

Reducing the enduring vulnerability to relapse is a therapeutic goal in treating drug addiction. Studies with animal models of drug addiction show a marked increase in extrasynaptic glutamate in the core subcompartment of the nucleus accumbens (NAcore) during reinstated drug seeking. However, the synaptic mechanisms linking drug-induced changes in extrasynaptic glutamate to relapse are poorly understood. Here, we discovered impaired glutamate elimination in rats extinguished from heroin self-administration that leads to spillover of synaptically released glutamate into the nonsynaptic extracellular space in NAcore and investigated whether restoration of glutamate transport prevented reinstated heroin seeking. Through multiple functional assays of glutamate uptake and analyzing NMDA receptor-mediated currents, we show that heroin self-administration produced long-lasting downregulation of glutamate uptake and surface expression of the transporter GLT-1. This downregulation was associated with spillover of synaptic glutamate to extrasynaptic NMDA receptors within the NAcore. Ceftriaxone restored glutamate uptake and prevented synaptic glutamate spillover and cue-induced heroin seeking. Ceftriaxone-induced inhibition of reinstated heroin seeking was blocked by morpholino-antisense targeting GLT-1 synthesis. These data reveal that the synaptic glutamate spillover in the NAcore results from reduced glutamate transport and is a critical pathophysiological mechanism underling reinstated drug seeking in rats extinguished from heroin self-administration. PMID:24741055

49 CFR 398.8 - Administration inspection of motor vehicles in operation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 5 2014-10-01 2014-10-01 false Administration inspection of motor vehicles in operation. 398.8 Section 398.8 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS TRANSPORTATION OF MIGRANT WORKERS ...

23 CFR 940.13 - Project administration.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Project administration. 940.13 Section 940.13 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INTELLIGENT TRANSPORTATION SYSTEMS INTELLIGENT TRANSPORTATION SYSTEM ARCHITECTURE AND STANDARDS § 940.13 Project administration. (a) Prior to...

23 CFR 940.13 - Project administration.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Project administration. 940.13 Section 940.13 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INTELLIGENT TRANSPORTATION SYSTEMS INTELLIGENT TRANSPORTATION SYSTEM ARCHITECTURE AND STANDARDS § 940.13 Project administration. (a) Prior to...

23 CFR 940.13 - Project administration.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Project administration. 940.13 Section 940.13 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INTELLIGENT TRANSPORTATION SYSTEMS INTELLIGENT TRANSPORTATION SYSTEM ARCHITECTURE AND STANDARDS § 940.13 Project administration. (a) Prior to...

23 CFR 940.13 - Project administration.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Project administration. 940.13 Section 940.13 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INTELLIGENT TRANSPORTATION SYSTEMS INTELLIGENT TRANSPORTATION SYSTEM ARCHITECTURE AND STANDARDS § 940.13 Project administration. (a) Prior to...

49 CFR 800.23 - Delegation to the administrative law judges, Office of Administrative Law Judges.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Delegation to the administrative law judges, Office of Administrative Law Judges. 800.23 Section 800.23 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL TRANSPORTATION SAFETY BOARD ORGANIZATION AND FUNCTIONS OF THE BOARD AND DELEGATIONS OF AUTHORITY Delegations of...

Nanostructured Surfaces for Drug Delivery and Anti-Fibrosis

NASA Astrophysics Data System (ADS)

Kam, Kimberly Renee

Effective and cost-efficient healthcare is at the forefront of public discussion; on both personal and policy levels, technologies that improve therapeutic efficacy without the use of painful hypodermic needle injections or the use of harsh chemicals would prove beneficial to patients. Nanostructured surfaces as structure-mediated permeability enhancers introduce a potentially revolutionary approach to the field of drug delivery. Parental administration routes have been the mainstay technologies for delivering biologics because these therapeutics are too large to permeate epithelial barriers. However, there is a significant patient dislike for hypodermic needles resulting in reduced patient compliance and poor therapeutic results. We present an alternative strategy to harness the body's naturally occurring biological processes and transport mechanisms to enhance the drug transport of biologics across the epithelium. Our strategy offers a paradigm shift from traditional biochemical drug delivery vehicles by using nanotopography to loosen the epithelial barrier. Herein, we demonstrate that nanotopographical cues can be used to enable biologics > 66 kDa to be transported across epithelial monolayers by increasing paracellular transport. When placed in contact with epithelial cells, nanostructured films significantly increase the transport of albumin, IgG, and a model therapeutic, etanercept. Our work highlights the potential to use drug delivery systems which incorporate nanotopographical cues to increase the transport of biologics across epithelial tissue. Furthermore, we describe current advancements in nano- and microfabrication for applications in anti-fibrosis and wound healing. Influencing cellular responses to biomaterials is crucial in the field of tissue engineering and regenerative medicine. Since cells are surrounded by extracellular matrix features that are on the nanoscale, identifying nanostructures for imparting desirable cellular function could greatly impact the field. Due to the rise in micro and nanofabrication techniques borrowed from the advances in the microelectronics industry, previously unattainable nanostructured surfaces on a variety of biomaterials can be generated. We investigated how nanostructured surfaces with varying nanofeature aspect ratios can influence fibrosis. Thus, nanostructured surfaces show substantial progress for therapeutic applications in drug delivery and wound healing.

49 CFR 98.11 - Final administrative decision.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Final administrative decision. 98.11 Section 98.11 Transportation Office of the Secretary of Transportation ENFORCEMENT OF RESTRICTIONS ON POST-EMPLOYMENT ACTIVITIES Administration of Enforcement Proceedings § 98.11 Final administrative decision. The final...

Diffusion algorithms and data reduction routine for onsite real-time launch predictions for the transport of Delta-Thor exhaust effluents

NASA Technical Reports Server (NTRS)

Stephens, J. B.

1976-01-01

The National Aeronautics and Space Administration/Marshall Space Flight Center multilayer diffusion algorithms have been specialized for the prediction of the surface impact for the dispersive transport of the exhaust effluents from the launch of a Delta-Thor vehicle. This specialization permits these transport predictions to be made at the launch range in real time so that the effluent monitoring teams can optimize their monitoring grids. Basically, the data reduction routine requires only the meteorology profiles for the thermodynamics and kinematics of the atmosphere as an input. These profiles are graphed along with the resulting exhaust cloud rise history, the centerline concentrations and dosages, and the hydrogen chloride isopleths.

46 CFR 308.407 - Premiums and payment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk... Administration, Department of Transportation, Washington, DC 20590, by check payable to the order of “Maritime Administration, Department of Transportation.” ...

46 CFR 308.407 - Premiums and payment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk... Administration, Department of Transportation, Washington, DC 20590, by check payable to the order of “Maritime Administration, Department of Transportation.” ...

46 CFR 308.407 - Premiums and payment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk... Administration, Department of Transportation, Washington, DC 20590, by check payable to the order of “Maritime Administration, Department of Transportation.” ...

46 CFR 308.407 - Premiums and payment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk... Administration, Department of Transportation, Washington, DC 20590, by check payable to the order of “Maritime Administration, Department of Transportation.” ...

76 FR 77302 - Federal Transit Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... reduce the energy consumption or greenhouse gas emissions of public transportation systems. The Clean... DEPARTMENT OF TRANSPORTATION Federal Transit Administration FY 2011 Discretionary Sustainability...: The U.S. Department of Transportation's (DOT) Federal Transit Administration (FTA) announces the...

49 CFR 193.2007 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY LIQUEFIED NATURAL GAS FACILITIES... Administrator, Pipeline and Hazardous Materials Safety Administration or his or her delegate. Ambient vaporizer...

78 FR 9771 - Federal Highway Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-11

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Notice of Final Federal Agency Action on Proposed Transportation Project in Illinois and Indiana AGENCY: Federal Highway Administration...., Acting Division Administrator, Federal Highway Administration, 3250 Executive Park Drive, Springfield...

77 FR 42354 - Designation of Transportation Management Areas

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-18

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Federal Highway Administration Designation of Transportation Management Areas AGENCIES: Federal Transit Administration (FTA), Federal Highway... Management Areas (TMAs). The FTA and FHWA are taking this action in compliance with the agencies' authorizing...

49 CFR 1510.7 - Air transportation advertisements and solicitations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Air transportation advertisements and solicitations. 1510.7 Section 1510.7 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES PASSENGER CIVIL AVIATION SECURITY SERVICE...

Pocket facts 2010 : the Swedish Transport Administration, railways, roads, traffic and transports

DOT National Transportation Integrated Search

2010-06-01

The Swedish Transport Administration is responsible : for the long-term planning of the transport : system for road, rail, shipping and aviation. : Our task is to develop an efficient and sustainable : transport system from a perspective that : encom...

76 FR 12211 - Commercial Space Transportation Advisory Committee-Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-04

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference (COMSTAC). SUMMARY: Pursuant...

Summary of Federal Aviation Administration Responses to National Transportation Safety Board Safety Recommendations

DTIC Science & Technology

1980-05-01

Langhorne M. Bond Administrator Federal Aviation Administration ) SAFETY RECOMMENDATICN(S) Washington, D. C. 20591, A-79-73 and -74... Langhorne M. Bond -2- Therefore, the National Transportation Safety Board recommends that the Federal Aviation Administration: Prescribe an appropriate method...TRANSPORTATION SAFETY BOARD WASHINGTON, D.C. ISSUED: October 17,.1979 i ----------- ----------------------- Forwarded to: Honorable Langhorne M. Bond

77 FR 42752 - New Agency Information Collection Activity Under OMB Review: Generic Clearance for the Collection...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... DEPARTMENT OF HOMELAND SECURITY Transportation Security Administration New Agency Information... Service Delivery AGENCY: Transportation Security Administration, DHS. ACTION: 30-day Notice. SUMMARY: This notice announces that the Transportation Security Administration (TSA) has forwarded the new Information...

76 FR 30236 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-24

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0061] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 31004 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-27

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0069] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 18300 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket Number MARAD-2011 0031] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 24563 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-02

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD 2011 0040] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 28846 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD 2011 0055] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 31007 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-27

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0066] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 55734 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0014] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 55734 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0012] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 24563 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-02

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD 2011 0042] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 6183 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-03

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011 0001] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 26793 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-09

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD 2011 0041] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 28846 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... DEPARTMENT OF TRANSPORTATION Maritime Administration Docket No. MARAD-2011-0052 Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 51467 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-18

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0105] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 30237 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-24

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0054] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 55733 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-08

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0113] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 29332 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-20

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011 0053] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 31007 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-27

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0065] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 35943 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-20

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0075] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 18299 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket Number MARAD 2011-0032] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 13701 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-14

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket Number MARAD-2011 0024] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 31006 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-27

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011-0064] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 30755 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-26

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2011 0068] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

76 FR 18299 - Requested Administrative Waiver of the Coastwise Trade Laws

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket Number MARAD 2011 0034] Requested Administrative Waiver of the Coastwise Trade Laws AGENCY: Maritime Administration, Department of Transportation. ACTION: Invitation for public comments on a requested administrative waiver of the Coastwise Trade Laws...

36 CFR 212.2 - Forest transportation program.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 36 Parks, Forests, and Public Property 2 2014-07-01 2014-07-01 false Forest transportation program... TRAVEL MANAGEMENT Administration of the Forest Transportation System § 212.2 Forest transportation... public at the headquarters of that administrative unit. (b) Forest transportation atlas. A forest...

36 CFR 212.2 - Forest transportation program.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 36 Parks, Forests, and Public Property 2 2012-07-01 2012-07-01 false Forest transportation program... TRAVEL MANAGEMENT Administration of the Forest Transportation System § 212.2 Forest transportation... public at the headquarters of that administrative unit. (b) Forest transportation atlas. A forest...

36 CFR 212.2 - Forest transportation program.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 36 Parks, Forests, and Public Property 2 2013-07-01 2013-07-01 false Forest transportation program... TRAVEL MANAGEMENT Administration of the Forest Transportation System § 212.2 Forest transportation... public at the headquarters of that administrative unit. (b) Forest transportation atlas. A forest...

Assessment of arsenic surface contamination in a museum anthropology department.

PubMed

Gribovich, Andrey; Lacey, Steven; Franke, John; Hinkamp, David

2013-02-01

To assess potential arsenic (As) contamination of work surfaces to improve upon the control strategy at an anthropology department in a large natural history museum. Work practices were observed and control strategy reviewed to inform an occupational hygiene assessment strategy utilizing surface wipe sampling. A total of 35 sampling targets were identified, focusing on surfaces that receive high touch traffic, including workstations, artifact transport carts, and elevator buttons. Arsenic sampling and analysis were performed using reference method Occupational Safety and Health Administration ID-125G. Four of the sampling areas returned detectable levels of As, ranging from 0.052 to 0.350 μg/100 cm. Workplace observations and wipe sampling data enabled the development of recommendations to help to further reduce potential occupational exposure to As. Continuous reduction of surface contamination is prudent for known human carcinogens.

76 FR 67018 - Commercial Space Transportation Advisory Committee-Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-28

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

77 FR 35102 - Commercial Space Transportation Advisory Committee; Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee; Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

78 FR 53496 - Commercial Space Transportation Advisory Committee; Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-29

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee; Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

75 FR 38866 - Commercial Space Transportation Advisory Committee-Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-06

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

75 FR 52058 - Commercial Space Transportation Advisory Committee-Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee-Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section 10...

76 FR 4743 - Commercial Space Transportation Advisory Committee-Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-26

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

76 FR 15041 - Commercial Space Transportation Advisory Committee-Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

77 FR 48585 - Commercial Space Transportation Advisory Committee-Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-14

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

75 FR 51332 - Commercial Space Transportation Advisory Committee-Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-19

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee--Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

78 FR 14401 - Commercial Space Transportation Advisory Committee; Public Teleconference

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-05

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Advisory Committee; Public Teleconference AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory Committee Teleconference. SUMMARY: Pursuant to Section...

49 CFR 109.17 - Emergency Orders.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION HAZARDOUS MATERIALS... an Administrator determines that a violation of a provision of the Federal hazardous material...

49 CFR 377.201 - Scope.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS PAYMENT OF TRANSPORTATION CHARGES... transportation of property under Federal Motor Carrier Safety Administration regulation by motor carriers and...

49 CFR 377.201 - Scope.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS PAYMENT OF TRANSPORTATION CHARGES... transportation of property under Federal Motor Carrier Safety Administration regulation by motor carriers and...

49 CFR 107.315 - Admission of violations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION HAZARDOUS MATERIALS... transfer may be obtained from the Financial Operations Division (AMZ-120), Federal Aviation Administration...

49 CFR 107.315 - Admission of violations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION HAZARDOUS MATERIALS... transfer may be obtained from the Financial Operations Division (AMZ-120), Federal Aviation Administration...

49 CFR 826.8 - Awards against the Federal Aviation Administration.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Awards against the Federal Aviation Administration. 826.8 Section 826.8 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL... Awards against the Federal Aviation Administration. When an applicant is entitled to an award because it...

49 CFR 826.8 - Awards against the Federal Aviation Administration.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Awards against the Federal Aviation Administration. 826.8 Section 826.8 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL... Awards against the Federal Aviation Administration. When an applicant is entitled to an award because it...

49 CFR 826.8 - Awards against the Federal Aviation Administration.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Awards against the Federal Aviation Administration. 826.8 Section 826.8 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL... Awards against the Federal Aviation Administration. When an applicant is entitled to an award because it...

49 CFR 826.8 - Awards against the Federal Aviation Administration.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Awards against the Federal Aviation Administration. 826.8 Section 826.8 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL... Awards against the Federal Aviation Administration. When an applicant is entitled to an award because it...

49 CFR 826.8 - Awards against the Federal Aviation Administration.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Awards against the Federal Aviation Administration. 826.8 Section 826.8 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL... Awards against the Federal Aviation Administration. When an applicant is entitled to an award because it...

77 FR 20094 - Intent To Prepare an Environmental Impact Statement on the Durham-Orange Light Rail (LRT) Project...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... Administration (FTA) and the Research Triangle Regional Public Transportation Authority, dba ``Triangle Transit... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Intent To Prepare an Environmental...: Federal Transit Administration (FTA), United States Department of Transportation (USDOT). ACTION: Notice...

49 CFR 1.37 - Assistant Secretary for Administration.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 1 2012-10-01 2012-10-01 false Assistant Secretary for Administration. 1.37 Section 1.37 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Office of the Secretary Ost Officials § 1.37 Assistant Secretary for Administration...

77 FR 37062 - Intent To Request Approval From OMB of One New Public Collection of Information: Office of Law...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-20

... DEPARTMENT OF HOMELAND SECURITY Transportation Security Administration Intent To Request Approval... Service LEO Reimbursement Request AGENCY: Transportation Security Administration, DHS. ACTION: 60-day Notice. SUMMARY: The Transportation Security Administration (TSA) invites public comment on a new...

49 CFR 1.98 - The Research and Innovative Technology Administration.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 1 2014-10-01 2014-10-01 false The Research and Innovative Technology Administration. 1.98 Section 1.98 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Operating Administrations § 1.98 The Research and Innovative Technology...

49 CFR 1.98 - The Research and Innovative Technology Administration.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 1 2013-10-01 2013-10-01 false The Research and Innovative Technology Administration. 1.98 Section 1.98 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Operating Administrations § 1.98 The Research and Innovative Technology...

49 CFR 1.98 - The Research and Innovative Technology Administration.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 1 2012-10-01 2012-10-01 false The Research and Innovative Technology Administration. 1.98 Section 1.98 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Operating Administrations § 1.98 The Research and Innovative Technology...

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

Code of Federal Regulations, 2012 CFR

2012-10-01

... alcohol testing rate. 219.608 Section 219.608 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs § 219.608 FRA Administrator's determination of random alcohol...

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

Code of Federal Regulations, 2011 CFR

2011-10-01

... alcohol testing rate. 219.608 Section 219.608 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs § 219.608 FRA Administrator's determination of random alcohol...

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

Code of Federal Regulations, 2014 CFR

2014-10-01

... alcohol testing rate. 219.608 Section 219.608 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs § 219.608 FRA Administrator's determination of random alcohol...

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

Code of Federal Regulations, 2010 CFR

2010-10-01

... alcohol testing rate. 219.608 Section 219.608 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs § 219.608 FRA Administrator's determination of random alcohol...

49 CFR 219.608 - FRA Administrator's determination of random alcohol testing rate.

Code of Federal Regulations, 2013 CFR

2013-10-01

... alcohol testing rate. 219.608 Section 219.608 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE Random Alcohol and Drug Testing Programs § 219.608 FRA Administrator's determination of random alcohol...

49 CFR 1.3 - Organization of the Department.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Organization of the Department. 1.3 Section 1.3 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General... Administration. (9) The Research and Innovative Technology Administration, headed by the Administrator. (10...

49 CFR 1.3 - Organization of the Department.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Organization of the Department. 1.3 Section 1.3 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General... Administration. (9) The Research and Innovative Technology Administration, headed by the Administrator. (10...

49 CFR 510.6 - Administrative depositions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 6 2011-10-01 2011-10-01 false Administrative depositions. 510.6 Section 510.6... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMATION GATHERING POWERS § 510.6 Administrative depositions. (a... entity to provide information as a witness at an administrative deposition. These depositions are for the...

75 FR 24773 - Research and Innovative Technology Administration Advisory Council on Transportation Statistics...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-05

... DEPARTMENT OF TRANSPORTATION Bureau of Transportation Statistics Research and Innovative Technology Administration Advisory Council on Transportation Statistics; Notice of Meeting AGENCY: Research...-363; 5 U.S.C. app. 2), a meeting of the Advisory Council on Transportation Statistics (ACTS). The...

78 FR 24309 - Pipeline and Hazardous Materials Safety Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration List of Special Permit Applications Delayed AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA..., Pipeline and Hazardous Materials Safety Administration, U.S. Department of Transportation, East Building...

49 CFR 601.21 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... statutes granting the Secretary authority to regulate public transportation. Administrator means the... 49 Transportation 7 2010-10-01 2010-10-01 false Definitions. 601.21 Section 601.21 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF...

Space transportation forecast conference, February 10-11, 1998 : Quarterly Launch Report : special report

DOT National Transportation Integrated Search

1998-01-01

The Federal Aviation Administration's Associate Administrator for Commercial Space Transportation (AST) convened the first national commercial space transportation forecast conference on February 10-11, 1998. For the theme, Commercial Space Transport...

77 FR 55265 - Notice of Meeting of the Transit Rail Advisory Committee for Safety (TRACS)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-07

... Secretary and the Federal Transit Administrator on matters relating to the safety of public transportation... Federal Transit Administration (FTA) on matters relating to the safety of public transportation systems... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Notice of Meeting of the Transit Rail...

77 FR 18716 - Transportation Security Administration Postal Zip Code Change; Technical Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-28

... organizational changes and it has no substantive effect on the public. DATES: Effective March 28, 2012. FOR... No. 1572-9] Transportation Security Administration Postal Zip Code Change; Technical Amendment AGENCY: Transportation Security Administration, DHS. ACTION: Final rule. SUMMARY: This rule is a technical change to...

77 FR 31866 - Intent To Request Approval From OMB of One New Public Collection of Information: Baseline...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-30

... (BASE) Program for Public Transportation Systems AGENCY: Transportation Security Administration, DHS. ACTION: 60-day Notice. SUMMARY: The Transportation Security Administration (TSA) invites public comment... under contract with a public transportation agency. \\1\\ TSA, ``Transportation Sector-Specific Plan Mass...

78 FR 41183 - Federal Aviation Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-09

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Meeting: RTCA Program Management Committee AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION... Operations Group, Federal Aviation Administration. [FR Doc. 2013-16464 Filed 7-8-13; 8:45 am] BILLING CODE...

49 CFR 1510.1 - Applicability and purpose.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES PASSENGER CIVIL AVIATION SECURITY SERVICE... intrastate air transportation originating at airports in the United States. [79 FR 35472, June 20, 2014] ...

49 CFR 1510.1 - Applicability and purpose.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES PASSENGER CIVIL AVIATION SECURITY SERVICE... intrastate air transportation originating at airports in the United States to pay for the costs of providing...

49 CFR 1510.1 - Applicability and purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES PASSENGER CIVIL AVIATION SECURITY SERVICE... intrastate air transportation originating at airports in the United States to pay for the costs of providing...

49 CFR 1510.1 - Applicability and purpose.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES PASSENGER CIVIL AVIATION SECURITY SERVICE... intrastate air transportation originating at airports in the United States to pay for the costs of providing...

49 CFR 1510.1 - Applicability and purpose.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES PASSENGER CIVIL AVIATION SECURITY SERVICE... intrastate air transportation originating at airports in the United States to pay for the costs of providing...

Scalable planar fabrication processes for chalcogenide-based topological insulators

NASA Astrophysics Data System (ADS)

Sharma, Peter; Henry, M. David; Douglas, Erica; Wiwi, Michael; Lima Sharma, Ana; Lewis, Rupert; Sugar, Joshua; Salehi, Maryam; Koirala, Nikesh; Oh, Seongshik

Surface currents in topological insulators are expected to have long spin diffusion lengths, which could lead to numerous applications. Experiments that show promising transport properties were conducted on exfoliated flakes from bulk material, thin films on substrates of limited dimensions, or bulk material, with limited yield. A planar thin film-based technology is needed to make topological insulator devices at scale and could also lead to new device designs. We address two problems related to fabricating chalcogenide-based topological insulator devices on 3'' wafers in the Sandia Microfabrication Facility using Bi2Te3 films. (2) Implantation damage and its subsequent mitigation through annealing is characterized. (2) The degradation in dielectric layers used to manipulate surface potential for elucidating topological surface state transport is characterized under different processing conditions. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under Contract No. DE-AC04-94AL85000. Funded by the Office of Naval Research (N0001416IP00098-0).

78 FR 26112 - Limitation on Claims Against Proposed Public Transportation Projects; Correction

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-03

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Limitation on Claims Against Proposed Public Transportation Projects; Correction AGENCY: Federal Transit Administration (FTA), DOT. ACTION... Register on April 22, 2013, concerning a limitation on claims for certain specified public transportation...

49 CFR 98.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Administration. (5) The National Highway Traffic Safety Administration. (6) The Urban Mass Transportation... 49 Transportation 1 2010-10-01 2010-10-01 false Definitions. 98.2 Section 98.2 Transportation Office of the Secretary of Transportation ENFORCEMENT OF RESTRICTIONS ON POST-EMPLOYMENT ACTIVITIES...

77 FR 40699 - Aviation Rulemaking Advisory Committee Teleconference on Transport Airplane and Engine Issues

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-10

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Aviation Rulemaking Advisory Committee Teleconference on Transport Airplane and Engine Issues AGENCY: Federal Aviation Administration... teleconference of the FAA's Aviation Rulemaking Advisory Committee (ARAC) to discuss transport airplane and...

77 FR 58607 - Office of Commercial Space Transportation Safety Approval Performance Criteria

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-21

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Office of Commercial Space...), FAA Office of Commercial Space Transportation (AST), 800 Independence Avenue SW., Room 331, Washington... September 17, 2012. George C. Nield, Associate Administrator for Commercial Space Transportation. [FR Doc...

49 CFR 1503.403 - Delegation of authority.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Delegation of authority. 1503.403 Section 1503.403 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION... Assessment of Civil Penalties by TSA § 1503.403 Delegation of authority. The Administrator delegates the...

49 CFR 1503.205 - Records, documents, and reports.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 9 2013-10-01 2013-10-01 false Records, documents, and reports. 1503.205 Section 1503.205 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES Investigative...

49 CFR 1503.201 - Reports of violations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 9 2013-10-01 2013-10-01 false Reports of violations. 1503.201 Section 1503.201 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES Investigative Procedures §...

Parallel barrier effectiveness under free-flowing traffic conditions

DOT National Transportation Integrated Search

1992-04-01

The U.S. Department of Transportation, Research and Special Programs Administration, Volpe National Transportation Systems Center, in support of the Federal Highway Administration and seventeen sponsoring state transportation agencies, is conducting ...

76 FR 46357 - Notice of Limitation on Claims Against Proposed Public Transportation Projects

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-02

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Notice of Limitation on Claims Against Proposed Public Transportation Projects AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice... that FTA has taken final agency actions by issuing certain approvals for the public transportation...

77 FR 26818 - Notice of Limitation on Claims Against Proposed Public Transportation Projects

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-07

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Notice of Limitation on Claims Against Proposed Public Transportation Projects AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice... public transportation projects listed below. The actions on these projects, as well as the laws under...

General health effects of transportation noise

DOT National Transportation Integrated Search

2002-08-19

The effects of transportation noise is a concern of many Government agencies, including the : Federal Aviation Administration (FAA), the Federal Highway Administration (FHWA), the : Federal Railroad Administration, National Parks Service, and the U.S...

Cerebrospinal and Interstitial Fluid Transport via the Glymphatic Pathway Modeled by Optimal Mass Transport

PubMed Central

Ratner, Vadim; Gao, Yi; Lee, Hedok; Elkin, Rena; Nedergaard, Maiken; Benveniste, Helene; Tannenbaum, Allen

2017-01-01

The glymphatic pathway is a system which facilitates continuous cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange and plays a key role in removing waste products from the rodent brain. Dysfunction of the glymphatic pathway may be implicated in the pathophysiology of Alzheimer's disease. Intriguingly, the glymphatic system is most active during deep wave sleep general anesthesia. By using paramagnetic tracers administered into CSF of rodents, we previously showed the utility of MRI in characterizing a macroscopic whole brain view of glymphatic transport but we have yet to define and visualize the specific flow patterns. Here we have applied an alternative mathematical analysis approach to a dynamic time series of MRI images acquired every 4 min over ∼3 hrs in anesthetized rats, following administration of a small molecular weight paramagnetic tracer into the CSF reservoir of the cisterna magna. We use Optimal Mass Transport (OMT) to model the glymphatic flow vector field, and then analyze the flow to find the network of CSF-ISF flow channels. We use 3D visualization computational tools to visualize the OMT defined network of CSF-ISF flow channels in relation to anatomical and vascular key landmarks from the live rodent brain. The resulting OMT model of the glymphatic transport network agrees largely with the current understanding of the glymphatic transport patterns defined by dynamic contrast-enhanced MRI revealing key CSF transport pathways along the ventral surface of the brain with a trajectory towards the pineal gland, cerebellum, hypothalamus and olfactory bulb. In addition, the OMT analysis also revealed some interesting previously unnoticed behaviors regarding CSF transport involving parenchymal streamlines moving from ventral reservoirs towards the surface of the brain, olfactory bulb and large central veins. PMID:28323163

Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport.

PubMed

Ratner, Vadim; Gao, Yi; Lee, Hedok; Elkin, Rena; Nedergaard, Maiken; Benveniste, Helene; Tannenbaum, Allen

2017-05-15

The glymphatic pathway is a system which facilitates continuous cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange and plays a key role in removing waste products from the rodent brain. Dysfunction of the glymphatic pathway may be implicated in the pathophysiology of Alzheimer's disease. Intriguingly, the glymphatic system is most active during deep wave sleep general anesthesia. By using paramagnetic tracers administered into CSF of rodents, we previously showed the utility of MRI in characterizing a macroscopic whole brain view of glymphatic transport but we have yet to define and visualize the specific flow patterns. Here we have applied an alternative mathematical analysis approach to a dynamic time series of MRI images acquired every 4min over ∼3h in anesthetized rats, following administration of a small molecular weight paramagnetic tracer into the CSF reservoir of the cisterna magna. We use Optimal Mass Transport (OMT) to model the glymphatic flow vector field, and then analyze the flow to find the network of CSF-ISF flow channels. We use 3D visualization computational tools to visualize the OMT defined network of CSF-ISF flow channels in relation to anatomical and vascular key landmarks from the live rodent brain. The resulting OMT model of the glymphatic transport network agrees largely with the current understanding of the glymphatic transport patterns defined by dynamic contrast-enhanced MRI revealing key CSF transport pathways along the ventral surface of the brain with a trajectory towards the pineal gland, cerebellum, hypothalamus and olfactory bulb. In addition, the OMT analysis also revealed some interesting previously unnoticed behaviors regarding CSF transport involving parenchymal streamlines moving from ventral reservoirs towards the surface of the brain, olfactory bulb and large central veins. Copyright © 2017. Published by Elsevier Inc.

76 FR 78332 - Amended Notice of Limitation on Claims Against Proposed Public Transportation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-16

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Amended Notice of Limitation on Claims Against Proposed Public Transportation Project AGENCY: Federal Transit Administration (FTA), DOT. ACTION... actions announced herein for the listed public transportation project will be barred unless the claim is...

76 FR 55470 - Notice of Limitation on Claims Against Proposed Public Transportation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-07

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Notice of Limitation on Claims Against Proposed Public Transportation Project AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice... announced herein for the listed public transportation project will be barred unless the claim is filed on or...

76 FR 4150 - Notice of Limitation on Claims Against Proposed Public Transportation Projects

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-24

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Notice of Limitation on Claims Against Proposed Public Transportation Projects AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice... public transportation project will be barred unless the claim is filed on or before July 25, 2011. FOR...

49 CFR 1503.637 - Standard of proof.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... must prove the party's case or defense by a preponderance of the evidence. ...

49 CFR 1503.637 - Standard of proof.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... must prove the party's case or defense by a preponderance of the evidence. ...

49 CFR 1503.637 - Standard of proof.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... must prove the party's case or defense by a preponderance of the evidence. ...

49 CFR 1503.637 - Standard of proof.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... must prove the party's case or defense by a preponderance of the evidence. ...

49 CFR 1503.637 - Standard of proof.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... must prove the party's case or defense by a preponderance of the evidence. ...

77 FR 58208 - Airport Privatization Pilot Program

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-19

... Department of Transportation (DOT), the Federal Aviation Administration and the Transportation Security... International Airport final application; the Transportation Security Administration will also participate... employees, airlines, aviation businesses and airport tenants, elected officials and community residents...

14 CFR 401.3 - The Associate Administrator for Commercial Space Transportation.

Code of Federal Regulations, 2010 CFR

2010-01-01

... space transportation by the United States private sector. [Doc. No. FAA-2006-24197, 72 FR 17016, Apr. 6... AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL ORGANIZATION AND DEFINITIONS § 401.3 The...

49 CFR 605.40 - Reports and information.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 7 2010-10-01 2010-10-01 false Reports and information. 605.40 Section 605.40 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION SCHOOL BUS OPERATIONS Reporting and Records § 605.40 Reports and information. The Administrator may order any grantee o...

Oregon Pupil Transportation Manual. Revised Regulations and Responsibilities.

ERIC Educational Resources Information Center

Oregon State Dept. of Education, Salem.

Designed for use by Oregon school bus drivers and administrators, this manual answers common questions about school bus transportation in Oregon, including those about the laws governing pupil transportation, the regulations governing pupil transportation administration, and the laws on school bus operation. A chapter of advisory materials covers…

49 CFR 1503.415 - Request for portions of the enforcement investigative report (EIR).

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 9 2013-10-01 2013-10-01 false Request for portions of the enforcement investigative report (EIR). 1503.415 Section 1503.415 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND...

TxDOT administration research : tasks completed in FY2009.

DOT National Transportation Integrated Search

2010-01-01

Texas Department of Transportation (TxDOT) Project 0-6581-TI, TxDOT Administration : Research, encompasses multiple tasks that explore and support administrative aspects of : transportation research. : The project term began in October 2008 and has b...

Federal Highway Administration university course on bicycle and pedestrian transportation. Lesson 2

DOT National Transportation Integrated Search

2006-07-01

The Federal Highway Administration (FHWA) University Course on Bicycle and Pedestrian Transportation contains modular resource material that is intended for use in university courses on bicycle and pedestrian transportation. This lesson explores the ...

Federal Highway Administration university course on bicycle and pedestrian transportation. Lesson 1

DOT National Transportation Integrated Search

2006-07-01

The Federal Highway Administration (FHWA) University Course on Bicycle and Pedestrian Transportation contains modular resource material that is intended for use in university courses on bicycle and pedestrian transportation. This lesson explores the ...

49 CFR 397.221 - Timeliness.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS TRANSPORTATION OF HAZARDOUS MATERIALS; DRIVING AND PARKING RULES Preemption Procedures § 397.221 Timeliness. If the Administrator fails to take...

Peer Review Of The National Highway Traffic Safety Administration Program, Workshop Proceedings

DOT National Transportation Integrated Search

1995-12-11

THE NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION PREPARED AN INTELLIGENT TRANSPORTATION SYSTEMS PROGRAM PLAN AS PART OF THE EARLY PLANNING FOR THE INTELLIGENT TRANSPORTATION SYSTEM (ITS) WORK WITHIN THE DEPARTMENT OF TRANSPORTATION. COMMERCIALIZATI...

49 CFR 392.2 - Applicable operating rules.

Code of Federal Regulations, 2011 CFR

2011-10-01

... care than that law, ordinance or regulation, the Federal Motor Carrier Safety Administration regulation... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS DRIVING OF COMMERCIAL MOTOR...

49 CFR 392.2 - Applicable operating rules.

Code of Federal Regulations, 2010 CFR

2010-10-01

... care than that law, ordinance or regulation, the Federal Motor Carrier Safety Administration regulation... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS DRIVING OF COMMERCIAL MOTOR...

PEGylated PLGA-based nanoparticles targeting M cells for oral vaccination.

PubMed

Garinot, Marie; Fiévez, Virginie; Pourcelle, Vincent; Stoffelbach, François; des Rieux, Anne; Plapied, Laurence; Theate, Ivan; Freichels, Hélène; Jérôme, Christine; Marchand-Brynaert, Jacqueline; Schneider, Yves-Jacques; Préat, Véronique

2007-07-31

To improve the efficiency of orally delivered vaccines, PEGylated PLGA-based nanoparticles displaying RGD molecules at their surface were designed to target human M cells. RGD grafting was performed by an original method called "photografting" which covalently linked RGD peptides mainly on the PEG moiety of the PCL-PEG, included in the formulation. First, three non-targeted formulations with size and zeta potential adapted to M cell uptake and stable in gastro-intestinal fluids, were developed. Their transport by an in vitro model of the human Follicle associated epithelium (co-cultures) was largely increased as compared to mono-cultures (Caco-2 cells). RGD-labelling of nanoparticles significantly increased their transport by co-cultures, due to interactions between the RGD ligand and the beta(1) intregrins detected at the apical surface of co-cultures. In vivo studies demonstrated that RGD-labelled nanoparticles particularly concentrated in M cells. Finally, ovalbumin-loaded nanoparticles were orally administrated to mice and induced an IgG response, attesting antigen ability to elicit an immune response after oral delivery.

78 FR 30390 - Applications Delayed More Than 180 Days

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-22

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Applications Delayed More Than 180 Days AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT..., Pipeline and Hazardous Materials Safety Administration, U.S. Department of Transportation, East Building...

78 FR 64285 - National Maritime Strategy Symposium: Cargo Opportunities and Sealift Capacity

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2013-0101] National Maritime Strategy Symposium: Cargo Opportunities and Sealift Capacity AGENCY: Maritime Administration...: The Maritime Administration (MARAD) invites the public and other Marine Transportation System...

76 FR 8400 - National Highway Traffic Safety Administration

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-14

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration Petition for Exemption From the Vehicle Theft Prevention Standard; Mitsubishi Motors AGENCY: National Highway Traffic Safety Administration (NHTSA) Department of Transportation (DOT). ACTION: Grant of petition for exemption. SUMMARY: This...

49 CFR 1.51 - Delegations to Federal Transit Administrator.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Plan No. 2 of 1968 (5 U.S.C. app. 1). (c) Section 10 of the Urban Mass Transportation Assistance Act of... 49 Transportation 1 2010-10-01 2010-10-01 false Delegations to Federal Transit Administrator. 1.51 Section 1.51 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF...

76 FR 70044 - Airworthiness Directives; ATR-GIE Avions de Transport Régional Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-10

... available in the AD docket shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

49 CFR 1503.407 - Military personnel.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... the Department of Defense who is subject to the Uniform Code of Military Justice (10 U.S.C. chapter 47...

49 CFR 1503.639 - Burden of proof.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... affirmative defense, the burden of proof is on the agency. (b) Except as otherwise provided by statute or rule...

49 CFR 1503.407 - Military personnel.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... the Department of Defense who is subject to the Uniform Code of Military Justice (10 U.S.C. chapter 47...

49 CFR 1503.639 - Burden of proof.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... affirmative defense, the burden of proof is on the agency. (b) Except as otherwise provided by statute or rule...

49 CFR 1503.407 - Military personnel.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... the Department of Defense who is subject to the Uniform Code of Military Justice (10 U.S.C. chapter 47...

49 CFR 1503.407 - Military personnel.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... the Department of Defense who is subject to the Uniform Code of Military Justice (10 U.S.C. chapter 47...

49 CFR 1503.639 - Burden of proof.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... affirmative defense, the burden of proof is on the agency. (b) Except as otherwise provided by statute or rule...

49 CFR 1503.639 - Burden of proof.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... affirmative defense, the burden of proof is on the agency. (b) Except as otherwise provided by statute or rule...

49 CFR 1503.407 - Military personnel.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... the Department of Defense who is subject to the Uniform Code of Military Justice (10 U.S.C. chapter 47...

49 CFR 1503.639 - Burden of proof.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... affirmative defense, the burden of proof is on the agency. (b) Except as otherwise provided by statute or rule...

Accessible Transportation Technologies Research Initiative (ATTRI) : User Needs Assessment: Stakeholder Engagement Report.

DOT National Transportation Integrated Search

2016-05-01

The Accessible Transportation Technologies Research Initiative (ATTRI) is a joint U.S. Department of Transportation (U.S. DOT) initiative that is co-led by the Federal Highway Administration (FHWA) and the Federal Transit Administration (FTA). ATTRI ...

49 CFR 192.951 - Where does an operator file a report?

Code of Federal Regulations, 2010 CFR

2010-10-01

... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Gas Transmission Pipeline... Pipeline Safety, Pipeline and Hazardous Materials Safety Administration, U.S. Department of Transportation...

Full-scale Transport Controlled Impact Demonstration Program

NASA Technical Reports Server (NTRS)

1987-01-01

The Federal Aviation Administration (FAA) and NASA conducted a full-scale air-to-surface impact-survivable impact demonstration with a remotely piloted transport aircraft on 1 December 1984, at Edwards Air Force Base, California. The test article consisted of experiments, special equipment, and supporting systems, such as antimisting kerosene (AMK), crashworthiness structural/restraint, analytical modeling, cabin fire safety, flight data recorders, post-impact investigation, instrumentation/data acquisition systems, remotely piloted vehicle/flight control systems, range and flight safety provisions, etc. This report describes the aircraft, experiments, systems, activities, and events which lead up to the Controlled Impact Demonstration (CID). An overview of the final unmanned remote control flight and sequence of impact events are delineated. Preliminary post CID observations are presented.

Simulator Evaluation of Runway Incursion Prevention Technology for General Aviation Operations

NASA Technical Reports Server (NTRS)

Jones, Denise R.; Prinzel, Lawrence J., III

2011-01-01

A Runway Incursion Prevention System (RIPS) has been designed under previous research to enhance airport surface operations situation awareness and provide cockpit alerts of potential runway conflict, during transport aircraft category operations, in order to prevent runway incidents while also improving operations capability. This study investigated an adaptation of RIPS for low-end general aviation operations using a fixed-based simulator at the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC). The purpose of the study was to evaluate modified RIPS aircraft-based incursion detection algorithms and associated alerting and airport surface display concepts for low-end general aviation operations. This paper gives an overview of the system, simulation study, and test results.

75 FR 910 - Airworthiness Directives; General Electric Company CF34-1A, -3A, -3A1, -3A2, -3B, and -3B1...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-07

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2007... AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule..., under the authority delegated to me by the Administrator, the Federal Aviation Administration amends 14...

An Analysis of Confederate Subsistence Logistics

DTIC Science & Technology

1989-09-01

Questions 2 Agricultural Production 2 Transportation 2 Administration 2 Justification for Research 3 Methodology 7 ’-7The Logical Argument . The...Impact of Transportation Policies 67 Overview 67 Impaot of the Industrial Revolution On Warfare . 67 The Desolation of Northern Virginia 68 Transportation ...143 Inadequate Comprehensive Planning 144 Agricultural Policies 147 Transportation Policies 148 Administrative Policies 149 National Policies 149

76 FR 54288 - Notice of Procedural Changes to the Performance and Registration Information Systems Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-31

... DEPARTMENT OF TRANSPORTATION Federal Motor Carrier Safety Administration Notice of Procedural... Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice; extension of effective date. SUMMARY..., Transportation Specialist, Office of Enforcement and Compliance, Federal Motor Carrier Safety Administration...

78 FR 26102 - Notice of Termination of Environmental Impact Statement for the Friedman Memorial Replacement...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-03

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Termination of... Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Notice. SUMMARY: The Federal Aviation Administration (FAA) announces its decision to terminate the Environmental Impact Statement (EIS...

78 FR 71030 - Ford Motor Company, Denial of Petition for Decision of Inconsequential Noncompliance

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2012... AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation (DOT... Compliance, the National Highway Traffic Safety Administration (NHTSA), telephone (202) 366-5298, facsimile...

23 CFR 810.8 - Coordination.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Coordination. 810.8 Section 810.8 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE... Transportation Administrator shall coordinate with each other on any projects involving public mass transit to...

49 CFR 389.7 - Records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 5 2013-10-01 2013-10-01 false Records. 389.7 Section 389.7 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF... REGULATIONS General § 389.7 Records. Records of the Administrator relating to rule making proceedings are...

49 CFR 389.7 - Records.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 5 2012-10-01 2012-10-01 false Records. 389.7 Section 389.7 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF... REGULATIONS General § 389.7 Records. Records of the Administrator relating to rule making proceedings are...

75 FR 63892 - Marine Transportation System National Advisory Council

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-18

... recommendations to the Secretary on matters relating to the Marine Transportation System. Such matters may include... System National Advisory Council AGENCY: Maritime Administration, DOT. ACTION: Request for applications. SUMMARY: The Maritime Administration seeks applications for membership on the Marine Transportation System...

49 CFR 389.7 - Records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 5 2011-10-01 2011-10-01 false Records. 389.7 Section 389.7 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF... REGULATIONS General § 389.7 Records. Records of the Administrator relating to rule making proceedings are...

49 CFR 389.7 - Records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Records. 389.7 Section 389.7 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF... REGULATIONS General § 389.7 Records. Records of the Administrator relating to rule making proceedings are...

49 CFR 191.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Estimated property damage, including cost of gas lost, of the operator or others, or both, of $50,000 or... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS... Administrator, Pipeline and Hazardous Materials Safety Administration or his or her delegate Gas means natural...

77 FR 20098 - Inventory of U.S.-Flag Launch Barges

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-03

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2012 0034] Inventory of U.S.-Flag Launch Barges AGENCY: Maritime Administration, Department of Transportation. ACTION: Inventory of U.S.-Flag Launch Barges. SUMMARY: The Maritime Administration is updating its inventory of U.S...

75 FR 13645 - Inventory of U.S.-Flag Launch Barges

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-22

... DEPARTMENT OF TRANSPORTATION Maritime Administration [Docket No. MARAD-2010 0023] Inventory of U.S.-Flag Launch Barges AGENCY: Maritime Administration, Department of Transportation. ACTION: Inventory of U.S.-Flag Launch Barges. SUMMARY: The Maritime Administration is updating its inventory of U.S...

49 CFR 397.201 - Purpose and scope of the procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS TRANSPORTATION OF HAZARDOUS MATERIALS; DRIVING AND PARKING RULES Preemption Procedures § 397.201 Purpose and... Administrator, who is the chief executive of the Federal Motor Carrier Safety Administration, an agency of the...

76 FR 68813 - FY 2011 Discretionary Livability Funding Opportunity; Section 5309 Bus and Bus Facilities...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-07

... subrecipients that are public agencies, private companies engaged in public transportation, or private non... DEPARTMENT OF TRANSPORTATION Federal Transit Administration FY 2011 Discretionary Livability... Transportation's (DOT) Federal Transit Administration (FTA) announces the selection of projects funded under two...

49 CFR 1.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Definitions. 1.2 Section 1.2 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.2... Maritime Administrator. (i) The Research and Innovative Technology Administrator. (j) The Federal Motor...

49 CFR 1.2 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Definitions. 1.2 Section 1.2 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES General § 1.2... Maritime Administrator. (i) The Research and Innovative Technology Administrator. (j) The Federal Motor...

75 FR 68185 - Airworthiness Directives; EADS CASA (Type Certificate Previously Held by Construcciones...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We...

49 CFR 192.949 - How does an operator notify PHMSA?

Code of Federal Regulations, 2013 CFR

2013-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF... Materials Safety Administration, U.S. Department of Transportation, Information Resources Manager, PHP-10... Management Database (IMDB) Web site at http://primis.rspa.dot.gov/gasimp/. [68 FR 69817, Dec. 15, 2003, as...

49 CFR 192.949 - How does an operator notify PHMSA?

Code of Federal Regulations, 2014 CFR

2014-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF... Materials Safety Administration, U.S. Department of Transportation, Information Resources Manager, PHP-10... Management Database (IMDB) Web site at http://primis.rspa.dot.gov/gasimp/. [68 FR 69817, Dec. 15, 2003, as...

49 CFR 192.949 - How does an operator notify PHMSA?

Code of Federal Regulations, 2012 CFR

2012-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF... Materials Safety Administration, U.S. Department of Transportation, Information Resources Manager, PHP-10... Management Database (IMDB) Web site at http://primis.rspa.dot.gov/gasimp/. [68 FR 69817, Dec. 15, 2003, as...

49 CFR 192.949 - How does an operator notify PHMSA?

Code of Federal Regulations, 2011 CFR

2011-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF... Materials Safety Administration, U.S. Department of Transportation, Information Resources Manager, PHP-10... Management Database (IMDB) Web site at http://primis.rspa.dot.gov/gasimp/. [68 FR 69817, Dec. 15, 2003, as...

Medicaid program; elimination of reimbursement under Medicaid for school administration expenditures and costs related to transportation of school-age children between home and school. Final rule.

PubMed

2007-12-28

Under the Medicaid program, Federal payment is available for the costs of administrative activities "as found necessary by the Secretary for the proper and efficient administration of the State plan." This final rule eliminates Federal Medicaid payment for the costs of certain school-based administrative and transportation activities because the Secretary has found that these activities are not necessary for the proper and efficient administration of the Medicaid State plan and are not within the definition of the optional transportation benefit. Based on these determinations, under this final rule, Federal Medicaid payments will no longer be available for administrative activities performed by school employees or contractors, or anyone under the control of a public or private educational institution, and for transportation from home to school. In addition, this final rule responds to public comments received on the September 7, 2007 proposed rule.

Estimating the effects of the transboundary transport and local emissions of atmospheric pollutants in South Korea during KORUS-AQ campaign

NASA Astrophysics Data System (ADS)

Lee, S.; Koo, J. H.; Hong, J.; Choi, M.; Kim, J.; Lim, H.; Holben, B. N.; Eck, T. F.; Ahn, J. Y.; Park, J.; Kim, S. K.

2017-12-01

The air quality of South Korea, located in the east of China, is affected by persistent westerlies, showing the relationship to the emission in upwind region. High aerosol concentration in South Korea is also attributed to local emissions. Particularly, the industrial complex and power plants are concentrated in the Chungcheongnam-do (CN), located by the southwest part of Seoul Metropolitan Area (SMA). In this study, we evaluate the contribution of both the transboundary transport of Chinese pollutants and local emissions in the CN to the air quality in South Korea during Korea-US Air Quality (KORUS-AQ) campaign, 1 May to 12 June in 2016. Based on the information of aerosol optical depth (AOD) obtained from ground-based Aerosol Robotic NETwork (AERONET) sunphotometer and surface in-situ Particulate Matter (PM) measurements at 19 stations, high and low aerosol pollution cases are classified first. Then, 2-day back-trajectories are calculated using National Ocean and Atmospheric Administration (NOAA) HYbrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model at each AERONET site to investigate whether transport pattern is different in accordance with the classified cases about aerosol amounts. As a result, we find the distinct pathway of air-mass transport from eastern China; When high AOD is observed at station located in the western coast of South Korea, air masses are directly transported from Shandong peninsular to the Korean peninsula. In contrast, air masses are mostly transported from northwestern or northern China during the period of low AOD conditions. When PM2.5 detected at SMA sites is greater than Korean government criteria (50 micrograms per cubic meter for 24-hour average PM2.5), SMA sites are mostly affected by air mass flows through the CN area. These results indicate that transport pattern can be different vertically and surface aerosol concentration has different transport pattern from the transport pattern related to the variation of total column aerosol.

49 CFR 501.4 - Succession to Administrator.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 6 2013-10-01 2013-10-01 false Succession to Administrator. 501.4 Section 501.4... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION AND DELEGATION OF POWERS AND DUTIES § 501.4 Succession... line of succession, officials must be encumbered in their position on a permanent basis. ...

49 CFR 501.4 - Succession to Administrator.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 6 2014-10-01 2014-10-01 false Succession to Administrator. 501.4 Section 501.4... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION AND DELEGATION OF POWERS AND DUTIES § 501.4 Succession... line of succession, officials must be encumbered in their position on a permanent basis. ...

23 CFR 810.208 - Action by the Federal Highway Administrator.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Action by the Federal Highway Administrator. 810.208 Section 810.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass...

23 CFR 810.208 - Action by the Federal Highway Administrator.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Action by the Federal Highway Administrator. 810.208 Section 810.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass...

23 CFR 810.208 - Action by the Federal Highway Administrator.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Action by the Federal Highway Administrator. 810.208 Section 810.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass...

23 CFR 420.103 - How does the FHWA define the terms used in this part?

Code of Federal Regulations, 2011 CFR

2011-04-01

... the Transportation Research Board, National Academy of Sciences. Procurement contract means a legal...? 420.103 Section 420.103 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PLANNING AND RESEARCH PLANNING AND RESEARCH PROGRAM ADMINISTRATION Administration of FHWA Planning and Research...

78 FR 33890 - Limitation on Claims Against Proposed Public Transportation Projects

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Limitation on Claims Against Proposed Public Transportation Projects AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice. SUMMARY... advising the public of final agency actions subject to Section 139(l) of Title 23, United States Code (U.S...

78 FR 4191 - Limitation on Claims Against Proposed Public Transportation Projects

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-18

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Limitation on Claims Against Proposed Public Transportation Projects AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice. SUMMARY... advising the public of final agency actions subject to Section 139(l) of Title 23, United States Code (U.S...

78 FR 16764 - Limitation on Claims Against Proposed Public Transportation Projects

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Limitation on Claims Against Proposed Public Transportation Projects AGENCY: Federal Transit Administration (FTA), DOT. ACTION: Notice. SUMMARY... advising the public of final agency actions subject to Section 139(l) of Title 23, United States Code (U.S...

Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse.

PubMed

Maisel, Katharina; Ensign, Laura; Reddy, Mihika; Cone, Richard; Hanes, Justin

2015-01-10

It is believed that mucoadhesive surface properties on particles delivered to the gastrointestinal (GI) tract improve oral absorption or local targeting of various difficult-to-deliver drug classes. To test the effect of nanoparticle mucoadhesion on distribution of nanoparticles in the GI tract, we orally and rectally administered nano- and microparticles that we confirmed possessed surfaces that were either strongly mucoadhesive or non-mucoadhesive. We found that mucoadhesive particles (MAP) aggregated in mucus in the center of the GI lumen, far away from the absorptive epithelium, both in healthy mice and in a mouse model of ulcerative colitis (UC). In striking contrast, water absorption by the GI tract rapidly and uniformly transported non-mucoadhesive mucus-penetrating particles (MPP) to epithelial surfaces, including reaching the surfaces between villi in the small intestine. When using high gavage fluid volumes or injection into ligated intestinal loops, common methods for assessing oral drug and nanoparticle absorption, we found that both MAP and MPP became well-distributed throughout the intestine, indicating that the barrier properties of GI mucus were compromised. In the mouse colorectum, MPP penetrated into mucus in the deeply in-folded surfaces to evenly coat the entire epithelial surface. Moreover, in a mouse model of UC, MPP were transported preferentially into the disrupted, ulcerated tissue. Our results suggest that delivering drugs in non-mucoadhesive MPP is likely to provide enhanced particle distribution, and thus drug delivery, in the GI tract, including to ulcerated tissues. Copyright © 2014 Elsevier B.V. All rights reserved.

Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice.

PubMed

Charoenphandhu, Narattaphol; Kraidith, Kamonshanok; Lertsuwan, Kornkamon; Sripong, Chanakarn; Suntornsaratoon, Panan; Svasti, Saovaros; Krishnamra, Nateetip; Wongdee, Kannikar

2017-03-01

Recent investigation has shown that the liver-derived iron-regulating hormone, hepcidin, can potentiate intestinal calcium absorption in hemizygous β-globin knockout thalassemic (BKO) mice. Since the upregulation of Fe 2+ and H + cotransporter, divalent metal transporter (DMT)-1, has been shown to correlate with thalassemia-induced intestinal calcium absorption impairment, the inhibition of the apical Na + /H + exchanger (NHE)-3 that is essential for cytoplasmic pH regulation and transepithelial sodium absorption was hypothesized to negatively affect hepcidin action. Herein, the positive effect of hepcidin on the duodenal calcium transport was evaluated using Ussing chamber technique. The results showed that BKO mice had lower absorptive surface area and duodenal calcium transport than wild-type mice. Besides, paracellular transport of zinc in BKO mice was compromised. Hepcidin administration completely restored calcium transport. Since this hepcidin action was totally abolished by inhibitors of the basolateral calcium transporters, Na + /Ca 2+ exchanger (NCX1) and plasma membrane Ca 2+ -ATPase (PMCA 1b ), the enhanced calcium flux potentially occurred through the transcellular pathway rather than paracellular pathway. Interestingly, the selective NHE3 inhibitor, 100 nM tenapanor, markedly inhibited hepcidin-enhanced calcium transport. Accordingly, hepcidin is one of the promising therapeutic agents for calcium malabsorption in β-thalassemia. It mainly stimulates the transcellular calcium transport across the duodenal epithelium in an NHE3-dependent manner.

The effects of mannitol on the transport of ciprofloxacin across respiratory epithelia.

PubMed

Ong, Hui Xin; Traini, Daniela; Salama, Rania; Anderson, Sandra D; Daviskas, Evangelia; Young, Paul M

2013-08-05

Inhalation of antibiotics and mucolytics is the most important combination of inhaled drugs for chronic obstructive lung diseases and has become a standard part of treatment. However, it is yet to be determined whether the administration of a mucolytic has an effect on the transport rate of antibiotics across the airway epithelial cells. Consequently, the aim of this study was to investigate the effects of inhalation dry powder, specifically mannitol, on ciprofloxacin transport using a Calu-3 air-interface cell model. Transport studies of ciprofloxacin HCl were performed using different configurations including single spray-dried ciprofloxacin alone, co-spray-dried ciprofloxacin with mannitol, and deposition of mannitol prior to ciprofloxacin deposition. To understand the mechanism of transport and interactions between the drugs, pH measurements of apical surface liquid (ASL) and further transport studies were performed with ciprofloxacin base, with and without the presence of ion channel/transport inhibitors such as disodium cromoglycate and furosemide. Mannitol was found to delay absorption of ciprofloxacin HCl through the increase in ASL volume and subsequent reduction in pH. Conversely, ciprofloxacin base had a higher transport rate after mannitol deposition. This study clearly demonstrates that the deposition of mannitol prior to ciprofloxacin on the air-interface Calu-3 cell model has an effect on its transport rate. This was also dependent on the salt form of the drug and the timing and sequence of formulations administered.

Reducing the Risk of Human Missions to Mars Through Testing

NASA Astrophysics Data System (ADS)

Drake, Bret G.

2007-07-01

The NASA Deputy Administrator charted an internal NASA planning group to develop the rationale for exploration beyond low-Earth orbit. This team, termed the Exploration Blueprint, performed architecture analyses to develop roadmaps for how to accomplish the first steps beyond Low-Earth Orbit through the human exploration of Mars. Following the results of the Exploration Blueprint study, the NASA Administrator asked for a recommendation on the next steps in human and robotic exploration. Much of the focus during this period was on integrating the results from the previous studies into more concrete implementation strategies in order to understand the relationship between NASA programs, timing, and resulting budgetary implications. This resulted in an integrated approach including lunar surface operations to retire risk of human Mars missions, maximum use of common and modular systems including what was termed the exploration transfer vehicle, Earth orbit and lunar surface demonstrations of long-life systems, collaboration of human and robotic missions to vastly increase mission return, and high-efficiency transportation systems (nuclear) for deep-space transportation and power. The data provided in this summary presentation was developed to begin to address one of the key elements of the emerging implementation strategy, namely how lunar missions help retire risk of human missions to Mars. During this process the scope of the activity broadened into the issue of how testing in general, in various venues including the moon, can help reduce the risk for Mars missions.

49 CFR 501.4 - Succession to Administrator.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Succession to Administrator. 501.4 Section 501.4... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION AND DELEGATION OF POWERS AND DUTIES § 501.4 Succession... succession, officials must be encumbered in their position on a permanent basis. [69 FR 63957, Nov. 3, 2004...

49 CFR 501.4 - Succession to Administrator.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 6 2011-10-01 2011-10-01 false Succession to Administrator. 501.4 Section 501.4... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION AND DELEGATION OF POWERS AND DUTIES § 501.4 Succession... succession, officials must be encumbered in their position on a permanent basis. [69 FR 63957, Nov. 3, 2004...

49 CFR 501.4 - Succession to Administrator.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 6 2012-10-01 2012-10-01 false Succession to Administrator. 501.4 Section 501.4... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ORGANIZATION AND DELEGATION OF POWERS AND DUTIES § 501.4 Succession... succession, officials must be encumbered in their position on a permanent basis. [69 FR 63957, Nov. 3, 2004...

Manual for School Administrators on Pupil Transportation.

ERIC Educational Resources Information Center

Tennessee State Dept. of Education, Nashville.

Guiding principles, state laws, and state board rules and regulations are covered, providing school administrators with a ready reference in the field of pupil transportation. Divided into three sections, the manual initially covers administrative procedures including--(1) the purchase of buses, (2) bus maintenance, (3) employment of drivers, (4)…

49 CFR 98.12 - Administrative sanctions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Office of the Secretary of Transportation ENFORCEMENT OF RESTRICTIONS ON POST-EMPLOYMENT ACTIVITIES Administrative Sanctions § 98.12 Administrative sanctions. (a) The Secretary, in decisions under § 98.10 of this part, and the examiner, in decisions under § 98.8 and § 98.9 of this part, may impose...

75 FR 51523 - Notice of Meeting of the Transit Rail Advisory Committee for Safety (TRACS)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

... Administration (FTA) on matters pertaining to the safety of public transportation systems. TRACS is composed of... Administration Eric Cheng, Utah Department of Transportation Richard W. Clark, California Public Utilities... Grizard, American Public Transportation Association Leonard Hardy, Bay Area Transit Authority Henry...

76 FR 16854 - Notice of Meeting of the Transit Rail Advisory Committee for Safety (TRACS)

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-25

... Secretary and the Federal Transit Administrator on matters relating to the safety of public transportation... to the safety of public transportation systems. TRACS is composed of 21 members representing a broad... DEPARTMENT OF TRANSPORTATION Federal Transit Administration Notice of Meeting of the Transit Rail...

78 FR 11732 - Agency Information Collection Activity; Notice of Request for Public Comment and Submission to...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-19

... AGENCY: Bureau of Transportation Statistics (BTS), Research and Innovative Technology Administration... Transportation Statistics, Research and Innovative Technology Administration, U.S. Department of Transportation, Office of Advanced Studies, RTS-31, 1200 New Jersey Avenue SE., Washington, DC 20590-0001; Phone No. (202...

41 CFR 102-118.420 - Can the Administrator of General Services waive the postpayment auditing provisions of this subpart?

Code of Federal Regulations, 2010 CFR

2010-07-01

....420 Public Contracts and Property Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION TRANSPORTATION 118-TRANSPORTATION PAYMENT AND AUDIT Postpayment Transportation Audits § 102-118.420 Can the Administrator of General Services waive the postpayment auditing...

School Transportation Issues, Laws and Concerns: Implications for Future Administrators

ERIC Educational Resources Information Center

Durick, Jody M.

2010-01-01

Nearly all building administrators are confronted with a variety of transportation issues. Challenges, concerns and questions can arise from various aspects, including student misbehaviors, transportation laws and its implications at the school level, to importance and implementation of a school bus safety program. As new and upcoming future…

78 FR 4856 - Intent To Request Renewal From OMB of One Current Public Collection of Information: TSA Customer...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-23

... DEPARTMENT OF HOMELAND SECURITY Transportation Security Administration Intent To Request Renewal...: Transportation Security Administration, DHS. ACTION: 60-Day notice. SUMMARY: The Transportation Security... provide feedback to TSA about their experiences with TSA's airport security process and procedures while...

76 FR 28639 - Airworthiness Directives; Bombardier, Inc. Model DHC-8-400 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new... http://www.regulations.gov or in person at the U.S. Department of Transportation, Docket Operations, M...

76 FR 27237 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model ERJ 170...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... IGW Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT... person at the U.S. Department of Transportation, Docket Operations, M-30, West Building Ground Floor...

75 FR 68174 - Airworthiness Directives; Bombardier, Inc. Model DHC-8-400 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... and placed it in the AD docket. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule; request for comments. SUMMARY: We...

75 FR 57666 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model EMB-120, -120ER...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-22

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009..., and -120RT Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT...

76 FR 50113 - Airworthiness Directives; Airbus Model A320-214, -232, and -233 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-12

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

75 FR 50867 - Airworthiness Directives; Airbus Model A330-223, -321, -322, and -323 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

75 FR 19201 - Airworthiness Directives; Empresa Brasileira de Aeronautica S.A. (EMBRAER) Model ERJ 170...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

75 FR 224 - Airworthiness Directives; Bombardier, Inc. (Type Certificate Previously Held by de Havilland, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009...-400 Series Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT....regulations.gov or in person at the U.S. Department of Transportation, Docket Operations, M-30, West Building...

75 FR 32263 - Airworthiness Directives; Bombardier, Inc. Model DHC-8-400 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-08

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

49 CFR 250.3 - Fees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Fees. 250.3 Section 250.3 Transportation Other... TRANSPORTATION GUARANTEE OF CERTIFICATES OF TRUSTEES OF RAILROADS IN REORGANIZATION § 250.3 Fees. On date of... Administrator as a guarantee fee such amount as the Administrator hereafter may determine and prescribe as...

Development of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats.

PubMed

Abdelmonem, Rehab; El Nabarawi, Mohamed; Attia, Alshaimaa

2018-11-01

The aim of this study was to formulate granisetron hydrochloride (GH) spanlastic in mucoadhesive gels and lyophilized inserts for intranasal administration to improve GH bioavailability and brain targeting. Carpapol 934 and HPMC were incorporated in GH spanlastic in nasal gels (GHSpNGs). Gelatin and HPMC as matrix former, glycine as a collapse protecting and mannitol as an insert filler and sweeting agent were used to prepare GH spanlastic loaded in lyophilized inserts (GHSpNIs). The prepared GHSpNGs were characterized for pH measurement, drug content, rheology, and in vitro drug release. The prepared GHSpNIs were characterized for drug content, surface pH, GH release, and mucoadhesion. Biological investigations including pharmacokinetics studies and brain drug targeting efficiency dimensions were performed on rats (LC-MS/MS). The results showed thixotropic pseudoplastic gels and white insert with pH values in a physiological range, drug content (89.9-98.6%), (82.4-98.38%) for gel and insert, respectively and rapid release rate of GH. Biological studies showed that C max and AUC 0-6 h in brain and plasma after intranasal administration of gel and insert were higher compared to IV administration of GH solution. A high brain targeting efficiency (199.3%, 230%) for gel and insert, respectively and a direct nose to brain transport (49.8%, 56.95%) for gel and insert, respectively confirmed that there is a direct nose to brain transport of GH following nasal administration of GH spanlastic loaded in nasal gel and insert. GHSpNIs can be considered as potential novel drug delivery system intended for brain targeting via the nasal rout of administration than GHSpNGs.

Low-cost warning device industry assessment

DOT National Transportation Integrated Search

2010-07-01

Under direction of the Federal Railroad Administrations Office of Research and Development, the U.S. Department of Transportations Research and Innovative Technology Administrations John A. Volpe National Transportation Systems Center conduc...

Measurement of highway-related noise

DOT National Transportation Integrated Search

1996-05-01

The U.S. Department of Transportation, Research and Special Programs Administration, John A. Volpe National Transportation Systems Center, Acoustics Facility, in support of the Federal Highway Administration (FHWA), Office of Environment and Planning...

PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats.

PubMed

Kaminskas, Lisa M; Kota, Jagannath; McLeod, Victoria M; Kelly, Brian D; Karellas, Peter; Porter, Christopher Jh

2009-12-03

Polylysine dendrimers have potential as highly flexible, biodegradable nanoparticular carriers that may also promote lymphatic transport. The current study was undertaken to determine the impact of PEGylation on the absorption and lymphatic transport of polylysine dendrimers modified by surface derivatisation with PEG (200, 570 or 2000Da) or 4-benzene sulphonate following SC or IV dosing. PEGylation led to the PEG(200) derived dendrimer being rapidly and completely absorbed into the blood after SC administration, however only 3% of the administered dose was recovered in pooled thoracic lymph over 30h. Increasing the PEG chain length led to a systematic decrease in absorption into the blood and an enhancement of the proportion recovered in the lymphatics (up to 29% over 30h). For the PEG(570) and PEG(2000) derived dendrimers, indirect access to the lymph via equilibration across the capillary beds also appeared to play a role in lymphatic targeting after both IV and SC dosing. In contrast, the anionic benzene sulphonate-capped dendrimer was not well absorbed from the SC injection site (26% bioavailability) into either the blood or the lymph. The data suggest that PEGylated poly-L-lysine dendrimers are well absorbed from SC injection sites and that the extent of lymphatic transport may be enhanced by increasing the size of the PEGylated dendrimer complex.

49 CFR 1242.77 - Administration (account XX-55-01).

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 9 2010-10-01 2010-10-01 false Administration (account XX-55-01). 1242.77 Section...-Transportation § 1242.77 Administration (account XX-55-01). Separate common expenses in the same proportion as... systems operations and loss and damage claims processing (accounts XX-55-76, XX-55-77 and XX-55-78). ...

49 CFR 1.87 - Delegations to the Federal Motor Carrier Safety Administrator.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Administrator. 1.87 Section 1.87 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Operating Administrations § 1.87 Delegations to the Federal Motor Carrier... Water Pollution Control Act, Public Law 87-88, as amended [33 U.S.C. 1321], to operate without approved...

49 CFR 1.87 - Delegations to the Federal Motor Carrier Safety Administrator.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Administrator. 1.87 Section 1.87 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Operating Administrations § 1.87 Delegations to the Federal Motor Carrier... Water Pollution Control Act, Public Law 87-88, as amended [33 U.S.C. 1321], to operate without approved...

49 CFR 1.87 - Delegations to the Federal Motor Carrier Safety Administrator.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Administrator. 1.87 Section 1.87 Transportation Office of the Secretary of Transportation ORGANIZATION AND DELEGATION OF POWERS AND DUTIES Operating Administrations § 1.87 Delegations to the Federal Motor Carrier... Water Pollution Control Act, Public Law 87-88, as amended [33 U.S.C. 1321], to operate without approved...

Aircraft Survivability. Spring 2009

DTIC Science & Technology

2009-01-01

transport and civil General Aviation (GA) aircraft by mitigating impact injury and keeping the occupants conscious and able to evacuate quickly. The AmSafe...representatives from the Federal Aviation Agency (FAA), the National Transportation Safety Board (NTSB), National Aeronautics & Space Administration...NASA), and the National Highway Transportation Safety Administration (NHTSA) to address and identify combat and mishap expertise, methodologies

75 FR 68698 - Airworthiness Directives; Airbus Model A330-201, -202, -203, -223, -223F, -243, and -243F...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-09

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We...

75 FR 50865 - Airworthiness Directives; Various Aircraft Equipped With Rotax Aircraft Engines 912 A Series Engines

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... available in the AD docket shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We...

75 FR 37991 - Airworthiness Directives; Airbus Model A330-243, -341, -342, and -343 Airplanes; and Model A340...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

75 FR 68172 - Airworthiness Directives; Piaggio Aero Industries S.p.A. Model PIAGGIO P-180 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new....regulations.gov or in person at Document Management Facility, U.S. Department of Transportation, Docket...

75 FR 7949 - Airworthiness Directives; Extra Flugzeugproduktions- und Vertriebs- GmbH Models EA-300/200 and EA...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-23

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final... Facility, U.S. Department of Transportation, Docket Operations, M-30, West Building Ground Floor, Room W12...

75 FR 50869 - Airworthiness Directives; Pilatus Aircraft Ltd. Model PC-12/47E Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

... available in the AD docket shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

75 FR 38011 - Airworthiness Directives; Bombardier, Inc. Model CL-600-2B16 (CL-604 Variant) Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... AD docket shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are...

75 FR 19199 - Airworthiness Directives; Airbus Model A330-200, A330-300, and A340-300 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-14

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2009... Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are...

75 FR 37994 - Airworthiness Directives; Bombardier, Inc. Model CL-600-1A11 (CL-600), CL-600-2A12 (CL-601), CL...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-01

... CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by reference, Safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We...

75 FR 49377 - Airworthiness Directives; BAE Systems (Operations) Limited Model Avro 146-RJ and BAe 146 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010...: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We...://www.regulations.gov or in person at the U.S. Department of Transportation, Docket Operations, M-30...

75 FR 68181 - Airworthiness Directives; Airbus Model A318, A319, A320, and A321 Series Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-05

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

76 FR 27240 - Airworthiness Directives; BURKHART GROB LUFT-UND Model G 103 C Twin III SL Gliders

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... AD docket shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

76 FR 59011 - Airworthiness Directives; BAE Systems (Operations) Limited Model BAe 146 and Avro 146-RJ Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-23

... available in the AD docket shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011...: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We...

Airspace Technology Demonstration 2 (ATD-2) Technology Description Document (TDD)

NASA Technical Reports Server (NTRS)

Ging, Andrew; Engelland, Shawn; Capps, Al; Eshow, Michelle; Jung, Yoon; Sharma, Shivanjli; Talebi, Ehsan; Downs, Michael; Freedman, Cynthia; Ngo, Tyler;

Railroad horn systems research

DOT National Transportation Integrated Search

1999-01-01

The U.S. Department of Transportation, Research and Special Programs Administration, Volpe National Transportation Systems Center, in support of the Federal Railroad Administration is conducting a research program with the goal of reducing the number...

Sodium channel blockers for cystic fibrosis.

PubMed

Burrows, E; Southern, K W; Noone, P

2006-07-19

People with cystic fibrosis (CF) have increased transport of the salt, sodium across their airway lining. Over-absorption of sodium results in the dehydration of the liquid that lines the airway surface and is a primary defect in people with CF. To determine whether the topical administration of drugs that block sodium transport improves the respiratory condition of people with CF. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Trials Register comprising references identified from comprehensive electronic database searches, handsearching relevant journals and abstract books of conference proceedings. We contacted principal investigators known to work in the field, previous authors and pharmaceutical companies who manufacture ion transport agents for unpublished or follow-up data. Most recent search of the Group's register: March 2006 Published or unpublished randomised controlled trials (RCTs) or quasi-randomised controlled trials of sodium channel blockers compared to placebo or another sodium channel blocker or the same sodium channel blocker at a different dosing regimen. Two authors independently extracted data. Meta-analysis was limited due to differing study designs. Four RCTs, with a total of 205 participants, examining the topical administration of the short-acting sodium channel blocker, amiloride, compared to placebo were identified as eligible for inclusion in the review. For three studies, interventions for six months were completed and it was possible to calculate relative change in respiratory function (FVC). There was a significant difference found in relative change in FVC in favour of placebo (GIV analysis of weighted mean difference for FVC; 1.51% (95% confidence interval -2.77 to -0.25). There were no significant differences identified in other clinically relevant outcomes. We found no evidence that the topical administration of a short-acting sodium channel blocker improves respiratory condition in people with cystic fibrosis and some limited evidence of deterioration in lung function.

U.S. Senate examines concerns about marine debris from 2011 Japan tsunami

NASA Astrophysics Data System (ADS)

Showstack, Randy

2012-05-01

Approximately 5 million tons of debris washed into the Pacific Ocean from Japan following the 11 March 2011 tsunami, and the Japanese government estimates that 1.5 million tons may still be floating on or below the ocean surface. However, it is not known how much debris may reach U.S. shores, an official from the National Oceanic and Atmospheric Administration (NOAA) testified at a 17 May Senate hearing. "If you've got 1.5 [million tons] that's floating and you leave it in there for a year, how much of that is still going be floating and available to come ashore? We don't have a clue," David Kennedy, NOAA assistant administrator for ocean services and coastal zone management, testified before a subcommittee of the Senate Committee on Commerce, Science, and Transportation. He said that some materials pushed by the wind could be expected to float but that materials pushed by currents under the surface are difficult to find. "A whole bunch of the 1.5 million is construction debris, and do [wooden] two-by-fours still float after a year? We're not sure."

Bolden at FAA Commercial Space Transportation Conference

NASA Image and Video Library

2011-02-09

NASA Administrator Charles Bolden speaks at the 14th Annual Federal Aviation Administration (FAA) Commercial Space Transport Conference at the Washington Convention Center on Wednesday, Feb. 9, 2001. Photo Credit: (NASA/Carla Cioffi)

Space-based navigation for RLVs and ELVs

DOT National Transportation Integrated Search

2006-02-08

The Aerospace Corporation was tasked by the Volpe National Transportation System Center to provide technical support to the Federal Aviation Administration, Office of the Associate Administrator for Commercial Space Transportation (FAA/AST), by perfo...

FHWA highway noise barrier design handbook

DOT National Transportation Integrated Search

2000-02-01

The U.S. Department of Transportation, Research and Special Programs Administration, John A. Volpe National Transportation Systems Center (Volpe Center), Acoustics Facility, in support of the Federal Highway Administration (FHWA), Office of Natural E...

49 CFR 1503.635 - Evidence.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY ADMINISTRATIVE AND PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES... present the party's case or defense by oral, documentary, or demonstrative evidence, to submit rebuttal...

Commercial Spacecraft Mission Model Update (1997)

DOT National Transportation Integrated Search

1997-05-01

The Federal Aviation Administration's (FAA) Office of the Associate : Administrator for Commercial Space Transportation (AST) of the U.S. Department : of Transportation (DOT) endeavors to foster a healthy commercial space launch : capability in the U...

49 CFR 224.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF... the Administrator of the Federal Railroad Administration or the Administrator's delegate. Associate Administrator means the Associate Administrator for Safety, Federal Railroad Administration, or the Associate...

Certification Study of a Derivative Model of a Small Jet Transport Airplane Using a Piloted Research Simulator

DTIC Science & Technology

1977-06-01

RESEARCH SIMULATOR • RAYMOND 0. FORREST SYSTEMS RESEARCH AND DEVELOPMENT SERVICE FEDERAL AVIATION ADMINISTRATION AMES RESEARCH CENTER MOFFE1T FIELD ...25 M o f f e t t Field , CA 94035 13. T ype of Repor t and P.r.od Co o er ed 12 . Sponsorrng Ar en cy Na me and Add eis ___________ U . S...dynamic stability derivatives of a complete airplane . The method utilizes potential flow theory to compute the surface flow fields and pressures on any

Risk Assessment of Carbon Fiber Composite in Surface Transportation

NASA Technical Reports Server (NTRS)

Hathaway, W. T.; Hergenrother, K. M.

1980-01-01

The vulnerability of surface transportation to airborne carbon fibers and the national risk associated with the potential use of carbon fibers in the surface transportation system were evaluated. Results show airborne carbon fibers may cause failure rates in surface transportation of less than one per year by 1995. The national risk resulting from the use of carbon fibers in the surface transportation system is discussed.

Capital Investment Plan

DTIC Science & Technology

1990-12-01

Title V, P.L. 97-248). o-r,/t:AA --TP,- -? -4o’s.3 US. Department 1fice of the Administrator 800 Independence Ave. S W of Transportation Washington. 0 C...20591 Federal Avicjion Administration As our Nation’s air transportation system grows in response to domestic and international demand, the Federal...FAA c𔃻| Strategic Plai which is consistent with the Secretary of Transportation’s National Transportation Policy. Capital investment in aviation

Department of Transportation Data Communications Requirements Analysis.

DTIC Science & Technology

1981-07-01

National Technical Information Service, Springfield, Virginia 22161. CJ0 us Department of Transportation FdeWAtcMk Adl*lt,. and Systems Research...General Administrative System . .. ................. 4.4 4.1.3 Coast Guard Administrative System . .. ............... 4.6 4.1.4 Transportation Automated...Office System .. .. ............ 4.6 4.1.5 OST Data Transmission Characteristics .. .. ............. 4.6 4.1.6 OST Data Communications

76 FR 52217 - Airworthiness Directives; Airbus Model A330-200, A330-300, A340-300, A340-500, and A340-600...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011... AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule...

76 FR 39248 - Airworthiness Directives; Airbus Model A300 B4-600, B4-600R, and F4-600R Series Airplanes, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-06

... after receipt. List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final rule...

76 FR 63156 - Airworthiness Directives; Fokker Services B.V. Model F.27 Mark 050, 200, 300, 400, 500, 600, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-12

... available in the AD docket shortly after receipt. List of Subjects in 14 CFR Part 39 Air transportation... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2011...; and Model F.28 Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation...

75 FR 68690 - Airworthiness Directives; Bombardier, Inc. Model BD-700-1A10 and BD-700-1A11 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-09

.... List of Subjects in 14 CFR Part 39 Air transportation, Aircraft, Aviation safety, Incorporation by... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2010... Administration (FAA), Department of Transportation (DOT). ACTION: Final rule. SUMMARY: We are adopting a new...

75 FR 75878 - Airworthiness Directives; Airbus Model A318-111 and A318-112 Airplanes and Model A319, A320, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2008... Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT). ACTION: Final... Transportation, Docket Operations, M-30, West Building Ground Floor, Room W12-140, 1200 New Jersey Avenue, SE...

Freight in America : a new national picture

DOT National Transportation Integrated Search

2006-01-01

According to new estimates by the Bureau of Transportation Statistics (BTS) of the U.S. Department of Transportations Research and Innovative Technology Administration (RITA) and the Federal Highway Administration (FHWA), over 19 billion tons of f...

Golden Gate Brokered Carpool: Report on Three Projects

DOT National Transportation Integrated Search

1985-10-01

n 1981, the Golden Gate Bridge, Highway and Transportation District (GGBHTD) received a National Ridesharing Demonstration Project grant from the Federal Highway Administration (FHWA) and the Urban Mass Transportation Administration to support the Di...

Noise measurement flight test of five light helicopters

DOT National Transportation Integrated Search

1993-07-01

The U.S. Department of Transportation, Federal Aviation Administration, (U.S.DOT/FAA), : along with the U.S. DOT, Research and Special Programs Administration, Volpe National : Transportation Systems Center (RSPA/Volpe Center) conducted a helicopter ...

Performance evaluation of experimental highway noise barriers

DOT National Transportation Integrated Search

1994-05-01

During the period October 1986 through April 1994, the U.S. Department of Transportation, Research and Special Programs Administration, John A. Volpe National Transportation Systems Center, in support of the Federal Highway Administration and 17 spon...

Noise & scope study for launch vehicles : final report

DOT National Transportation Integrated Search

2009-03-01

In support of the Federal Aviation Administration (FAA) Office of the Associate Administrator Commercial Space Transportation (AST), the John A. Volpe National Transportation Systems Center (Volpe Center) has retained the services of Harris Miller Mi...

77 FR 28894 - Maritime Vulnerability Self-Assessment Tool

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-16

... DEPARTMENT OF HOMELAND SECURITY Transportation Security Administration Maritime Vulnerability Self... maritime vulnerability self- assessment tool. SUMMARY: The Transportation Security Administration (TSA... conducting vulnerability assessments became available and usage of the TMSARM has dropped off considerably...

78 FR 60726 - Hazardous Materials Regulations: Penalty Guidelines

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

..., Radioactive Materials, Compressed Gases in cylinders; Packaging Manufacturers, Drum Manufacturers and... Administrative practices and procedure, Hazardous materials transportation, Packaging and containers, Penalties... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Part...

North Carolina "Sealed Corridor" phase IV assessment -- private crossings

DOT National Transportation Integrated Search

2012-07-31

The U.S. Department of Transportations (USDOT) Federal Railroad Administration tasked the USDOT Research and Innovative Technology Administrations John A. Volpe National Transportation Systems Center to document the success of the safety improv...

Rail transportation : Federal Railroad Administration's safety programs

DOT National Transportation Integrated Search

1998-05-20

Federal Railroad Administration (FRA) enforces federal railroad safety statutes under a delegation of authority from the Secretary of Transportation. FRA's mission is to protect railroad employees and the public by ensuring the safe operation of frei...

78 FR 69744 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-20

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [NHTSA-2013-0117] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on proposed collection of...

49 CFR 224.5 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.5 Definitions. Administrator means the Administrator of the Federal Railroad Administration or the Administrator's delegate. Associate Administrator means the Associate Administrator for Safety, Federal Railroad Administration, or the Associate...

49 CFR 224.5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.5 Definitions. Administrator means the Administrator of the Federal Railroad Administration or the Administrator's delegate. Associate Administrator means the Associate Administrator for Safety, Federal Railroad Administration, or the Associate...

49 CFR 224.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... TRANSPORTATION REFLECTORIZATION OF RAIL FREIGHT ROLLING STOCK General § 224.5 Definitions. Administrator means the Administrator of the Federal Railroad Administration or the Administrator's delegate. Associate Administrator means the Associate Administrator for Safety, Federal Railroad Administration, or the Associate...

76 FR 72240 - Twenty-Seventh Meeting: RTCA Special Committee 206: Aeronautical Information and Meteorological...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-22

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Twenty-Seventh Meeting: RTCA Special... Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Special Committee 206..., 2011 FRAC OSED [[Page 72241

14 CFR 413.7 - Application.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.7 Application. (a) Form. An application must be in writing, in English and filed in duplicate with the Federal Aviation Administration, Associate...

Flight Evaluation of LORAN-C in the State of Vermont

DOT National Transportation Integrated Search

1981-09-01

The Transportation Systems Center, Langley Research Center, the Federal Aviation Administration, and the Agency of Transportation, State of Vermont conducted a program sponsored by the Research and Special Programs Administration of the Department of...

Developing an undergraduate degree in public transportation administration and management : feasibility study results.

DOT National Transportation Integrated Search

2006-11-01

Experiences and results of research by the North Carolina Central University Department of Public Administration while a : conducting feasibility study for establishing a new multidisciplinary undergraduate degree in public transportation administrat...

Los Angeles Downtown People Mover (DPM) Operational Analysis

DOT National Transportation Integrated Search

1981-06-01

Two different studies were performed by the Research and Special Programs Administration of the Transportation Systems Center in response to the concerns of the Urban Mass Transportation Administration about the ability of the planned Los Angeles Dow...

77 FR 11623 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-27

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2011-0154] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration, Department of Transportation. ACTION: Notice. SUMMARY: In compliance with the Paperwork Reduction...

76 FR 72747 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-25

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2011-0154] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on proposed collection...

75 FR 59321 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2010-0086] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation (DOT). ACTION: Request for public comment on proposed...

76 FR 28300 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-16

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2010-0124] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Notice. SUMMARY: In compliance with the Paperwork...

75 FR 4447 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-27

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0010] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

78 FR 25351 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2013-0002] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Notice. SUMMARY: In compliance with the Paperwork...

76 FR 74845 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0164] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

77 FR 7658 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-13

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0165] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

76 FR 11848 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-03

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2011-0001] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation (NHTSA). ACTION: Request for extension of a currently...

75 FR 59319 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-27

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0124] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

76 FR 24957 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-03

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2011-0051] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for extension of a currently approved...

76 FR 9633 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-18

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0086] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

76 FR 74846 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0165] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

78 FR 57000 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-16

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2013-0096] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

75 FR 13806 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-23

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0027] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

76 FR 210 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-03

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket No. NHTSA-2010-0111] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for extension of a currently approved...

75 FR 54217 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0124] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

77 FR 6855 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2012--0014] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

75 FR 34521 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0085] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

75 FR 54218 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-03

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0123] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

77 FR 7659 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-13

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0164] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

77 FR 11621 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-27

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0169] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on...

49 CFR 237.155 - Documents and records.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... inspection and reproduction by the Federal Railroad Administration. (a) Electronic recordkeeping; general... the information required by this part; (3) The track owner monitors its electronic records database...

49 CFR 237.155 - Documents and records.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... inspection and reproduction by the Federal Railroad Administration. (a) Electronic recordkeeping; general... the information required by this part; (3) The track owner monitors its electronic records database...

49 CFR 237.155 - Documents and records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... inspection and reproduction by the Federal Railroad Administration. (a) Electronic recordkeeping; general... the information required by this part; (3) The track owner monitors its electronic records database...

Study of the acoustic characteristics of railroad horn systems

DOT National Transportation Integrated Search

1993-07-01

The U.S. Department of Transportation, Research and Special Programs Administration, Volpe National Transportation Systems Center, in support of the Federal Railroad Administration is conducting a research program with the goal of reducing the number...

State Transportation Statistics 2012

DOT National Transportation Integrated Search

2013-08-15

The Bureau of Transportation Statistics (BTS), a part of the U.S. Department of Transportation's (USDOT) Research and Innovative Technology Administration (RITA), presents State Transportation Statistics 2012, a statistical profile of transportation ...

National Space Transportation Policy: Issues for Congress

NASA Astrophysics Data System (ADS)

1995-05-01

This report, prepared for the House Committee on Science, is the first in a broad assessment of the health and future prospects of the U.S. space transportation technology and industrial base. The report focuses on the Clinton Administration's National Space Transportation Policy, which was released last fall. It examines administration policy in light of the implementation plans prepared by NASA, DOD, and the Transportation and Commerce Departments. The policy also emphasizes the important contribution private industry can make to the direction and development of U.S. space transportation capabilities. However, an analysis of the policy and implementation plans also raises some issues that might be of interest to Congress as it debates space transportation legislation, oversight, and funding. These issues involve decisions on NASA and DOD development programs, the use of foreign launch vehicles, and the new role of the private sector in space transportation research and development decisionmaking. This report also identifies two issues omitted from the Administration's policy: the preservation of long-range ballistic missile capabilities after final production in 2005, and the perspective of lower industrial tier firms toward national space transportation policy.

41 CFR 302-7.303 - What guidelines must we follow when authorizing transportation of PBP&E as an administrative...

Code of Federal Regulations, 2010 CFR

2010-07-01

... to CONUS as an agency administrative expense for an employee separating from Government service. ... follow when authorizing transportation of PBP&E as an administrative expense? 302-7.303 Section 302-7.303... BOOKS, PAPERS, AND EQUIPMENT (PBP&E) Agency Responsibilities § 302-7.303 What guidelines must we follow...

41 CFR 302-7.303 - What guidelines must we follow when authorizing transportation of PBP&E as an administrative...

Code of Federal Regulations, 2011 CFR

2011-07-01

... to CONUS as an agency administrative expense for an employee separating from Government service. ... follow when authorizing transportation of PBP&E as an administrative expense? 302-7.303 Section 302-7.303... BOOKS, PAPERS, AND EQUIPMENT (PBP&E) Agency Responsibilities § 302-7.303 What guidelines must we follow...

The interactions of single-wall carbon nanohorns with polar epithelium.

PubMed

Shi, Yujie; Shi, Zujin; Li, Suxin; Zhang, Yuan; He, Bing; Peng, Dong; Tian, Jie; Zhao, Ming; Wang, Xueqing; Zhang, Qiang

2017-01-01

Single-wall carbon nanohorns (SWCNHs), which have multitudes of horn interstices, an extensive surface area, and a spherical aggregate structure, offer many advantages over other carbon nanomaterials being used as a drug nanovector. The previous studies on the interaction between SWCNHs and cells have mostly emphasized on cellular uptake and intracellular trafficking, but seldom on epithelial cells. Polar epithelium as a typical biological barrier constitutes the prime obstacle for the transport of therapeutic agents to target site. This work tried to explore the permeability of SWCNHs through polar epithelium and their abilities to modulate transcellular transport, and evaluate the potential of SWCNHs in drug delivery. Madin-Darby canine kidney (MDCK) cell monolayer was used as a polar epithelial cell model, and as-grown SWCNHs, together with oxidized and fluorescein isothiocyanate-conjugated bovine serum albumin-labeled forms, were constructed and comprehensively investigated in vitro and in vivo. Various methods such as transmission electron microscopy and confocal imaging were used to visualize their intracellular uptake and localization, as well as to investigate the potential transcytotic process. The related mechanism was explored by specific inhibitors. Additionally, fast multispectral optoacoustic tomography imaging was used for monitoring the distribution and transport process of SWCNHs in vivo after oral administration in nude mice, as an evidence for their interaction with the intestinal epithelium. The results showed that SWCNHs had a strong bioadhesion property, and parts of them could be uptaken and transcytosed across the MDCK monolayer. Multiple mechanisms were involved in the uptake and transcytosis of SWCNHs with varying degrees. After oral administration, oxidized SWCNHs were distributed in the gastrointestinal tract and retained in the intestine for up to 36 h probably due to their surface adhesion and endocytosis into the intestinal epithelium. Overall, this comprehensive investigation demonstrated that SWCNHs can serve as a promising nanovector that can cross the barrier of polar epithelial cells and deliver drugs effectively.

Prehospital Blood Product Administration Opportunities in Ground Transport ALS EMS - A Descriptive Study.

PubMed

Mix, Felicia M; Zielinski, Martin D; Myers, Lucas A; Berns, Kathy S; Luke, Anurahda; Stubbs, James R; Zietlow, Scott P; Jenkins, Donald H; Sztajnkrycer, Matthew D

2018-06-01

IntroductionHemorrhage remains the major cause of preventable death after trauma. Recent data suggest that earlier blood product administration may improve outcomes. The purpose of this study was to determine whether opportunities exist for blood product transfusion by ground Emergency Medical Services (EMS). This was a single EMS agency retrospective study of ground and helicopter responses from January 1, 2011 through December 31, 2015 for adult trauma patients transported from the scene of injury who met predetermined hemodynamic (HD) parameters for potential transfusion (heart rate [HR]≥120 and/or systolic blood pressure [SBP]≤90). A total of 7,900 scene trauma ground transports occurred during the study period. Of 420 patients meeting HD criteria for transfusion, 53 (12.6%) had a significant mechanism of injury (MOI). Outcome data were available for 51 patients; 17 received blood products during their emergency department (ED) resuscitation. The percentage of patients receiving blood products based upon HD criteria ranged from 1.0% (HR) to 5.9% (SBP) to 38.1% (HR+SBP). In all, 74 Helicopter EMS (HEMS) transports met HD criteria for blood transfusion, of which, 28 patients received prehospital blood transfusion. Statistically significant total patient care time differences were noted for both the HR and the SBP cohorts, with HEMS having longer time intervals; no statistically significant difference in mean total patient care time was noted in the HR+SBP cohort. In this study population, HD parameters alone did not predict need for ED blood product administration. Despite longer transport times, only one-third of HEMS patients meeting HD criteria for blood administration received prehospital transfusion. While one-third of ground Advanced Life Support (ALS) transport patients manifesting HD compromise received blood products in the ED, this represented 0.2% of total trauma transports over the study period. Given complex logistical issues involved in prehospital blood product administration, opportunities for ground administration appear limited within the described system. MixFM, ZielinskiMD, MyersLA, BernsKS, LukeA, StubbsJR, ZietlowSP, JenkinsDH, SztajnkrycerMD. Prehospital blood product administration opportunities in ground transport ALS EMS - a descriptive study. Prehosp Disaster Med. 2018;33(3):230-236.

Transportation statistics annual report 2005

DOT National Transportation Integrated Search

2005-11-01

In this edition of the Transportation Statistics Annual Report, the Bureau : of Transportation Statistics (BTS) of the U.S. Department of Transportation, : Research and Innovative Technology Administration (RITA), : focuses on transportation indicato...

75 FR 3959 - Railroad Safety Advisory Committee; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-25

... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 58] Railroad Safety Advisory Committee; Notice of Meeting AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Announcement of Railroad Safety Advisory Committee...

75 FR 31834 - Adoption of Environmental Impact Statement; Availability of an Environmental Reevaluation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Adoption of Environmental Impact Statement; Availability of an Environmental Reevaluation AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Adoption and Recirculation of Final Environmental Impact...

75 FR 13807 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-23

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... of Transportation, Pipeline and Hazardous Materials Safety Administration, 1200 New Jersey Avenue, SE...: Updates to Pipeline and Liquefied Natural Gas Reporting Requirements (One Rule). The Notice of Proposed...

23 CFR 260.117 - Application procedures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... representatives, Urban Mass Transportation Administration regional directors, major transit authorities and from... 23 Highways 1 2010-04-01 2010-04-01 false Application procedures. 260.117 Section 260.117 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION NATIONAL HIGHWAY INSTITUTE EDUCATION AND...

Integrating intelligent transportation systems within the transportation planning process : an interim handbook.

DOT National Transportation Integrated Search

1998-01-01

The Final Rule on Statewide Planning and Metropolitan Planning issued by the Federal Highway Administration (FHWA) and Federal Transit Administration (FTA) in October, 1993 established revised and more comprehensive processes for metropolitan and sta...

75 FR 18942 - FY 2010 Discretionary Sustainability Funding Opportunity; Transit Investments for Greenhouse Gas...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration FY 2010 Discretionary Sustainability... Transit Administration (FTA), DOT. ACTION: Notice of availability of FTA environmental sustainability.... Department of Transportation's (DOT) environmental sustainability efforts. This notice includes priorities...

49 CFR 397.213 - Waiver of preemption application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS TRANSPORTATION OF HAZARDOUS MATERIALS; DRIVING AND PARKING RULES Preemption Procedures § 397.213 Waiver of... preemption determination must: (1) Be submitted to the Administrator, Federal Motor Carrier Safety...

46 CFR 308.513 - Payment of premiums and fees.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION EMERGENCY OPERATIONS WAR RISK INSURANCE War Risk Cargo Insurance Open Policy War Risk Cargo Insurance § 308.513 Payment of premiums and fees. The... ”Maritime Administration, Department of Transportation.” ...

77 FR 30352 - Reports, Forms, and Record Keeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket Number NHTSA-2012-0064] Reports, Forms, and Record Keeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on proposed collection...

76 FR 6515 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0181] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), U.S. Department of Transportation. ACTION: Request for public comment on...

76 FR 20438 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-12

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0181 ] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), U.S. Department of Transportation. ACTION: Notice. SUMMARY: In compliance...

78 FR 20172 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-03

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [Docket Number NHTSA-2013-0044] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), U.S. Department of Transportation (DOT). ACTION: Request for public comment on extension...

76 FR 6514 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0011] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on an...

76 FR 35270 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-16

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0025] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on a...

76 FR 6513 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2010-0182] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), U.S. Department of Transportation. ACTION: Request for public comment on...

76 FR 6512 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-04

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket Number NHTSA-2011-0010] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on an...

75 FR 17831 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-07

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [DOT Docket Number NHTSA-2010-0010] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation. ACTION: Request for public comment on extension of a...

75 FR 21385 - Reports, Forms, and Recordkeeping Requirements

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-23

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration [U.S. DOT Docket No. NHTSA-2010-0023] Reports, Forms, and Recordkeeping Requirements AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation (DOT). ACTION: Request for public comment on proposed...

76 FR 45904 - Pipeline Safety: Information Collection Activities

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-01

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration [Docket No... at U.S. Department of Transportation, Pipeline and Hazardous Materials Safety Administration, 1200...: On Occasion. Title: Record Keeping for Natural Gas Pipeline Operators. OMB Control Number: 2137-0049...

State transportation statistics 2008

DOT National Transportation Integrated Search

2008-01-01

The Bureau of Transportation Statistics (BTS), a part of the U.S. Department of Transportations : Research and Innovative Technology Administration, presents State Transportation : Statistics 2008, a statistical profi le of transportation in the 5...

36 CFR 13.460 - Use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

Code of Federal Regulations, 2010 CFR

2010-07-01

..., motorboats, dog teams, and other means of surface transportation traditionally employed by local rural... of snowmobiles, motorboats, dog teams, and other means of surface transportation traditionally... this chapter, the use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

36 CFR 13.460 - Use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

Code of Federal Regulations, 2012 CFR

2012-07-01

..., motorboats, dog teams, and other means of surface transportation traditionally employed by local rural... of snowmobiles, motorboats, dog teams, and other means of surface transportation traditionally... this chapter, the use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

36 CFR 13.460 - Use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

Code of Federal Regulations, 2014 CFR

2014-07-01

..., motorboats, dog teams, and other means of surface transportation traditionally employed by local rural... of snowmobiles, motorboats, dog teams, and other means of surface transportation traditionally... this chapter, the use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

36 CFR 13.460 - Use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

Code of Federal Regulations, 2011 CFR

2011-07-01

..., motorboats, dog teams, and other means of surface transportation traditionally employed by local rural... of snowmobiles, motorboats, dog teams, and other means of surface transportation traditionally... this chapter, the use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

36 CFR 13.460 - Use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

Code of Federal Regulations, 2013 CFR

2013-07-01

..., motorboats, dog teams, and other means of surface transportation traditionally employed by local rural... of snowmobiles, motorboats, dog teams, and other means of surface transportation traditionally... this chapter, the use of snowmobiles, motorboats, dog teams, and other means of surface transportation...

Transportation of perishable and refrigerated foods in mylar foil bags and insulated containers: a time-temperature study.

PubMed

Li, Yanyan; Schrade, John P; Su, Haiyan; Specchio, John J

2014-08-01

Data are lacking on the temperature changes of food during transport without the use of refrigerated trucks. The purpose of this study was to evaluate the ability of several insulated and noninsulated containers with or without frozen gel packs to keep perishable and refrigerated foods within the temperature safe zone in relationship to duration of transport. The study was designed to duplicate the practices exhibited by customers purchasing perishable food products from a cash-and-carry business. Approximately 40 perishable food items were evaluated. Four types of containers were tested: a mylar foil bag, a commercial insulated bag, a generic insulated bag, and a commercial insulated blanket. Mixed foods were placed into these containers with or without frozen gel packs, transported in unrefrigerated vehicles, and monitored for 4 h for temperature changes. Two environmental temperatures, room temperature of 21.1°C and a stress temperature of 37.8°C, were evaluated. The internal temperature and surface temperature of the food products in these containers increased slowly but remained well below the U.S. Food and Drug Administration Food Code requirements. The various containers were similar in their ability to retain coolness. The presence of frozen gel packs dramatically enhanced the cold-holding capacity of the containers. The temperature of foods increased more rapidly when stressed in a heated environment. The containers tested used with the frozen gel packs can keep the surface and internal temperatures of various perishable foods (starting at 4.4°C or less) within the Food Code recommendation of under 21.1°C for 4 h. Cash-and-carry businesses should strongly encourage their retail customers to utilize these containers with frozen gel packs to safely transport perishable foods.

49 CFR 173.448 - General transportation requirements.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false General transportation requirements. 173.448 Section 173.448 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SHIPPERS...

49 CFR 173.448 - General transportation requirements.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 2 2011-10-01 2011-10-01 false General transportation requirements. 173.448 Section 173.448 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SHIPPERS...

49 CFR 173.448 - General transportation requirements.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 2 2014-10-01 2014-10-01 false General transportation requirements. 173.448 Section 173.448 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SHIPPERS...

77 FR 28421 - Railroad Safety Advisory Committee; Charter Renewal

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257: Notice No. 70] Railroad Safety Advisory Committee; Charter Renewal AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Announcement of Charter Renewal of the Railroad Safety Advisory...

75 FR 27053 - Railroad Safety Advisory Committee; Charter Renewal

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-13

... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket No. FRA-2000-7257; Notice No. 61] Railroad Safety Advisory Committee; Charter Renewal AGENCY: Federal Railroad Administration (FRA), Department of Transportation (DOT). ACTION: Announcement of Charter Renewal of the Railroad Safety Advisory...

78 FR 69785 - Airworthiness Directives; Slingsby Aviation Ltd. Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-21

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 39 [Docket No. FAA-2013-0997; Directorate Identifier 2013-CE-044-AD] RIN 2120-AA64 Airworthiness Directives; Slingsby Aviation Ltd. Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation (DOT...

76 FR 39151 - Agency Information Collection Activity Under OMB Review

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... DEPARTMENT OF TRANSPORTATION Federal Transit Administration [FTA Docket No. FTA-2011-0038 ] Agency Information Collection Activity Under OMB Review AGENCY: Federal Transit Administration, DOT. ACTION: Notice... authorities for financing mass transportation projects. Grant recipients are required to make information...

14 CFR 406.111 - Signing documents.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Signing documents. 406.111 Section 406.111 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space...

14 CFR 406.111 - Signing documents.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Signing documents. 406.111 Section 406.111 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE REVIEW Rules of Practice in FAA Space...

78 FR 40264 - First Meeting: RTCA Tactical Operations Committee (TOC)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration First Meeting: RTCA Tactical Operations Committee (TOC) AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation..., Leadership Anticipated Issues for TOC consideration and action at the next meeting. Any Other Business...

78 FR 16757 - First Meeting: RTCA Tactical Operations Committee (TOC)

Federal Register 2010, 2011, 2012, 2013, 2014

2013-03-18

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration First Meeting: RTCA Tactical Operations Committee (TOC) AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation... FAA Task Groups Discussion Anticipated Issues for TOC consideration and action at the next meeting...

77 FR 49861 - Notice of Application for Special Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-17

.... transportation in commerce of certain Radioactive material in alternative packaging by highway. (mode 1). 15671-N... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration Notice of Application for Special Permits AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT...

77 FR 70876 - Revised Guidance for Requesting One-Time Movement Approvals (OTMA)

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-27

... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration Revised Guidance for Requesting One-Time Movement Approvals (OTMA) AGENCY: Federal Railroad Administration (FRA), Department of... revised guidance for requesting one-time movement approvals (OTMA) for the transportation by rail of...

75 FR 51392 - Federal Management Regulation; Transportation Management

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-20

...; Docket Number 2010-0011, sequence 1] RIN 3090-AJ03 Federal Management Regulation; Transportation Management AGENCY: Office of Governmentwide Policy, General Services Administration (GSA). ACTION: Final rule. SUMMARY: The General Services Administration (GSA) is amending the Federal Management Regulation (FMR) by...

77 FR 18306 - Agency Information Collection; Activity Under OMB Review; Airline Service Quality Performance

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-27

... DEPARTMENT OF TRANSPORTATION Research & Innovative Technology Administration [Docket ID No. RITA... Performance AGENCY: Research & Innovative Technology Administration (RITA), Bureau of Transportation... travelers information concerning the on-time performance history of flights that they are considering...

Evaluation on newly developed high resolution of surface solar radiation from MTSAT observations for the Tibetan Plateau

NASA Astrophysics Data System (ADS)

Niu, X.; Yang, K.; Tang, W.; Qin, J.

2015-12-01

Neither surface measurement nor existing remote sensing products of the Surface Solar Radiation (SSR) can meet the application requirements of hydrological and land process modeling in the Tibetan Plateau (TP). High resolution (hourly; 0.1⁰) of SSR estimates have been derived recently from the geostationary satellite observations - the Multi-functional Transport Satellite (MTSAT). This SSR estimation is based on updating an existing physical model, the UMD-SRB (University of Maryland Surface Radiation Budget) which is the basis of the well-known GEWEX-SRB model. In the updated framework introduced is the high-resolution Global Land Surface Broadband Albedo Product (GLASS) with spatial continuity. The developed SSR estimates are demonstrated at different temporal resolutions over the TP and are evaluated against ground observations and other satellite products from: (1) China Meteorological Administration (CMA) radiation stations in TP; (2) three TP radiation stations contributed from the Institute of Tibetan Plateau Research; (3) and the universal used satellite products (i.e. ISCCP-FD, GEWEX-SRB) in relatively low spatial resolution (0.5º-2.5º) and temporal resolution (3-hourly, daily, or monthly).

University Transportation Center : administration manual.

DOT National Transportation Integrated Search

2013-01-01

University Transportation Centers (UTCs) were established by the U.S. Department of : Transportation (USDOT) in 1987. UTCs are part of an on-going federal government effort to : improve transportation research, transportation education and to stre...

49 CFR 109.17 - Emergency Orders.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS PROCEDURAL REGULATIONS FOR OPENING OF PACKAGES, EMERGENCY ORDERS, AND...

49 CFR 109.17 - Emergency Orders.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS PROCEDURAL REGULATIONS FOR OPENING OF PACKAGES, EMERGENCY ORDERS, AND...

49 CFR 109.17 - Emergency Orders.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS PROCEDURAL REGULATIONS FOR OPENING OF PACKAGES, EMERGENCY ORDERS, AND...

49 CFR 109.3 - Inspections and Investigations.

Code of Federal Regulations, 2011 CFR

2011-10-01

....3 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS AND OIL TRANSPORTATION DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS PROCEDURAL REGULATIONS FOR OPENING OF PACKAGES, EMERGENCY...

49 CFR 385.327 - May a new entrant request an administrative review of a determination of a failed safety audit?

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 5 2014-10-01 2014-10-01 false May a new entrant request an administrative review of a determination of a failed safety audit? 385.327 Section 385.327 Transportation Other Regulations... Program § 385.327 May a new entrant request an administrative review of a determination of a failed safety...

49 CFR 385.327 - May a new entrant request an administrative review of a determination of a failed safety audit?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false May a new entrant request an administrative review of a determination of a failed safety audit? 385.327 Section 385.327 Transportation Other Regulations... Program § 385.327 May a new entrant request an administrative review of a determination of a failed safety...

49 CFR 385.327 - May a new entrant request an administrative review of a determination of a failed safety audit?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 5 2013-10-01 2013-10-01 false May a new entrant request an administrative review of a determination of a failed safety audit? 385.327 Section 385.327 Transportation Other Regulations... Program § 385.327 May a new entrant request an administrative review of a determination of a failed safety...

49 CFR 385.327 - May a new entrant request an administrative review of a determination of a failed safety audit?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 5 2012-10-01 2012-10-01 false May a new entrant request an administrative review of a determination of a failed safety audit? 385.327 Section 385.327 Transportation Other Regulations... Program § 385.327 May a new entrant request an administrative review of a determination of a failed safety...

FAA/NASA Proceedings, Workshop on Wake Vortex Alleviation and Avoidance. Presented at the U.S. Department of Transportation Research and Special Programs Administration Transportation Systems Center, Cambridge, MA 02142, November 28-29, 1978.

DOT National Transportation Integrated Search

1979-10-01

This document is a record of the joint FAA/NASA Workshop on Wake Vortex Alleviation and Avoidance conducted at the DOT Transportation Systems Center, November 28-29, 1978. The workshop was sponsored by the Federal Aviation Administration to apprise t...

29 CFR 1926.902 - Surface transportation of explosives.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 29 Labor 8 2014-07-01 2014-07-01 false Surface transportation of explosives. 1926.902 Section 1926... Explosives § 1926.902 Surface transportation of explosives. (a) Transportation of explosives shall meet the provisions of Department of Transportation regulations contained in 46 CFR parts 146-149, Water Carriers; 49...

29 CFR 1926.902 - Surface transportation of explosives.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 8 2012-07-01 2012-07-01 false Surface transportation of explosives. 1926.902 Section 1926... Explosives § 1926.902 Surface transportation of explosives. (a) Transportation of explosives shall meet the provisions of Department of Transportation regulations contained in 46 CFR parts 146-149, Water Carriers; 49...

29 CFR 1926.902 - Surface transportation of explosives.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 8 2011-07-01 2011-07-01 false Surface transportation of explosives. 1926.902 Section 1926... Explosives § 1926.902 Surface transportation of explosives. (a) Transportation of explosives shall meet the provisions of Department of Transportation regulations contained in 46 CFR parts 146-149, Water Carriers; 49...

29 CFR 1926.902 - Surface transportation of explosives.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 8 2013-07-01 2013-07-01 false Surface transportation of explosives. 1926.902 Section 1926... Explosives § 1926.902 Surface transportation of explosives. (a) Transportation of explosives shall meet the provisions of Department of Transportation regulations contained in 46 CFR parts 146-149, Water Carriers; 49...

Airport Traffic Conflict Detection and Resolution Algorithm Evaluation

NASA Technical Reports Server (NTRS)

Jones, Denise R.; Chartrand, Ryan C.; Wilson, Sara R.; Commo, Sean A.; Otero, Sharon D.; Barker, Glover D.

2012-01-01

A conflict detection and resolution (CD&R) concept for the terminal maneuvering area (TMA) was evaluated in a fast-time batch simulation study at the National Aeronautics and Space Administration (NASA) Langley Research Center. The CD&R concept is being designed to enhance surface situation awareness and provide cockpit alerts of potential conflicts during runway, taxi, and low altitude air-to-air operations. The purpose of the study was to evaluate the performance of aircraft-based CD&R algorithms in the TMA, as a function of surveillance accuracy. This paper gives an overview of the CD&R concept, simulation study, and results. The Next Generation Air Transportation System (NextGen) concept for the year 2025 and beyond envisions the movement of large numbers of people and goods in a safe, efficient, and reliable manner [1]. NextGen will remove many of the constraints in the current air transportation system, support a wider range of operations, and provide an overall system capacity up to three times that of current operating levels. Emerging NextGen operational concepts [2], such as four-dimensional trajectory based airborne and surface operations, equivalent visual operations, and super density arrival and departure operations, require a different approach to air traffic management and as a result, a dramatic shift in the tasks, roles, and responsibilities for the flight deck and air traffic control (ATC) to ensure a safe, sustainable air transportation system.

Surface transport processes in charged porous media

DOE PAGES

Gabitto, Jorge; Tsouris, Costas

2017-03-03

Surface transport processes are important in chemistry, colloidal sciences, engineering, biology, and geophysics. Natural or externally produced charges on surfaces create electrical double layers (EDLs) at the solid-liquid interface. The existence of the EDLs produces several complex processes including bulk and surface transport of ions. In this work, a model is presented to simulate bulk and transport processes in homogeneous porous media comprising big pores. It is based on a theory for capacitive charging by ideally polarizable porous electrodes without Faradaic reactions or specific adsorption of ions. A volume averaging technique is used to derive the averaged transport equations inmore » the limit of thin electrical double layers. Description of the EDL between the electrolyte solution and the charged wall is accomplished using the Gouy-Chapman-Stern (GCS) model. The surface transport terms enter into the average equations due to the use of boundary conditions for diffuse interfaces. Two extra surface transports terms appear in the closed average equations. One is a surface diffusion term equivalent to the transport process in non-charged porous media. The second surface transport term is a migration term unique to charged porous media. The effective bulk and transport parameters for isotropic porous media are calculated solving the corresponding closure problems.« less

Surface transport processes in charged porous media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gabitto, Jorge; Tsouris, Costas

Surface transport processes are important in chemistry, colloidal sciences, engineering, biology, and geophysics. Natural or externally produced charges on surfaces create electrical double layers (EDLs) at the solid-liquid interface. The existence of the EDLs produces several complex processes including bulk and surface transport of ions. In this work, a model is presented to simulate bulk and transport processes in homogeneous porous media comprising big pores. It is based on a theory for capacitive charging by ideally polarizable porous electrodes without Faradaic reactions or specific adsorption of ions. A volume averaging technique is used to derive the averaged transport equations inmore » the limit of thin electrical double layers. Description of the EDL between the electrolyte solution and the charged wall is accomplished using the Gouy-Chapman-Stern (GCS) model. The surface transport terms enter into the average equations due to the use of boundary conditions for diffuse interfaces. Two extra surface transports terms appear in the closed average equations. One is a surface diffusion term equivalent to the transport process in non-charged porous media. The second surface transport term is a migration term unique to charged porous media. The effective bulk and transport parameters for isotropic porous media are calculated solving the corresponding closure problems.« less

49 CFR 665.25 - Transportation of vehicle.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Transportation of vehicle. 665.25 Section 665.25 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING Operations § 665.25 Transportation of vehicle. A manufacturer shall...

49 CFR 665.25 - Transportation of vehicle.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Transportation of vehicle. 665.25 Section 665.25 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING Operations § 665.25 Transportation of vehicle. A manufacturer shall...

49 CFR 665.25 - Transportation of vehicle.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Transportation of vehicle. 665.25 Section 665.25 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL TRANSIT ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BUS TESTING Operations § 665.25 Transportation of vehicle. A manufacturer shall...

76 FR 21790 - Environmental Impact Statement: Interstate 66 Corridor, Virginia

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-18

... Transportation and Virginia Department of Rail and Public Transportation, for potential transportation... Transportation (VDOT) and Virginia Department of Rail and Public Transportation (VDRPT), will prepare a Tier 1... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Environmental Impact Statement...

75 FR 23841 - Commercial Space Transportation Grant Program

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-04

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation Grant... for the Commercial Space Transportation Grant Program. SUMMARY: The FAA's Office of Commercial Space Transportation (AST) requests grant proposals pursuant to its newly funded Commercial Space Transportation Grant...

77 FR 71474 - Commercial Space Transportation Advisory Committee-Charter Renewal

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-30

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Commercial Space Transportation... Transportation (DOT). ACTION: Announcement of Charter Renewal of the Commercial Space Transportation Advisory... space transportation industry. This charter renewal will take effect on November 16, 2012, and will...

49 CFR 1580.201 - Rail security coordinator.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 9 2013-10-01 2013-10-01 false Rail security coordinator. 1580.201 Section 1580.201 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY MARITIME AND LAND TRANSPORTATION SECURITY RAIL TRANSPORTATION...

49 CFR 1580.201 - Rail security coordinator.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 9 2011-10-01 2011-10-01 false Rail security coordinator. 1580.201 Section 1580.201 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY MARITIME AND LAND TRANSPORTATION SECURITY RAIL TRANSPORTATION...

49 CFR 192.65 - Transportation of pipe.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) PIPELINE SAFETY TRANSPORTATION OF NATURAL AND OTHER GAS BY PIPELINE: MINIMUM FEDERAL SAFETY STANDARDS Materials § 192.65 Transportation of pipe. (a) Railroad...

Functionalized PLA-PEG nanoparticles targeting intestinal transporter PepT1 for oral delivery of acyclovir.

PubMed

Gourdon, Betty; Chemin, Caroline; Moreau, Amélie; Arnauld, Thomas; Baumy, Philippe; Cisternino, Salvatore; Péan, Jean-Manuel; Declèves, Xavier

2017-08-30

Targeting intestinal di- and tri-peptide transporter PepT1 with prodrugs is a successful strategy to improve oral drug bioavailability, as demonstrated with valacyclovir, a prodrug of acyclovir. The aim of this new drug delivery strategy is to over-concentrate a poorly absorbed drug on the intestinal membrane surface by targeting PepT1 with functionalized polymer nanoparticles. In the present study, poly(lactic acid)-poly(ethylene glycol)-ligand (PLA-PEG-ligand) nanoparticles were obtained by nanoprecipitation. A factorial experimental design allowed us to identify size-influent parameters and to obtain optimized ≈30nm nanoparticles. Valine, Glycylsarcosine, Valine-Glycine, and Tyrosine-Valine were chemically linked to PLA-PEG. In Caco-2 cell monolayer model, competition between functionalized nanoparticles and [ 3 H]Glycylsarcosine, a strong substrate of PepT1, reduced [ 3 H]Glycylsarcosine transport from 22 to 46%. Acyclovir was encapsulated with a drug load of ≈10% in valine-functionalized nanoparticles, resulting in a 2.7-fold increase in permeability as compared to the free drug. An in vivo pharmacokinetic study in mice compared oral absorption of acyclovir after administration of 25mg/kg of valacyclovir, free or encapsulated acyclovir in functionalized nanoparticles. Acyclovir encapsulation did not statistically modify AUC or C max , but increased t 1/2 and MRT 1.3-fold as compared to free acyclovir. This new strategy is promising for poorly absorbed drugs by oral administration. Copyright © 2017 Elsevier B.V. All rights reserved.

National Transportation Atlas Databases : 2014

DOT National Transportation Integrated Search

2014-01-01

The National Transportation Atlas Databases 2014 : (NTAD2014) is a set of nationwide geographic datasets of : transportation facilities, transportation networks, associated : infrastructure, and other political and administrative entities. : These da...

National Transportation Atlas Databases : 2015

DOT National Transportation Integrated Search

2015-01-01

The National Transportation Atlas Databases 2015 : (NTAD2015) is a set of nationwide geographic datasets of : transportation facilities, transportation networks, associated : infrastructure, and other political and administrative entities. : These da...

New York Metropolitan Transportation Council scenario planning workshop : sponsored by the Federal Highway Administration

DOT National Transportation Integrated Search

2016-01-01

This report summarizes noteworthy practices and key recommendations shared during a scenario planning workshop, hosted by the New York Metropolitan Transportation Council, on July 14-15, 2015, in New York, New York. The Federal Highway Administration...

76 FR 74723 - New Car Assessment Program (NCAP); Safety Labeling

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-01

... DEPARTMENT OF TRANSPORTATION National Highway Traffic Safety Administration 49 CFR Part 575 [Docket No. NHTSA 2010-0025] RIN 2127-AK51 New Car Assessment Program (NCAP); Safety Labeling AGENCY: National Highway Traffic Safety Administration (NHTSA), Department of Transportation (DOT). ACTION...

75 FR 48593 - Pipeline Safety: Periodic Updates of Regulatory References to Technical Standards and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-11

... DEPARTMENT OF TRANSPORTATION Pipeline and Hazardous Materials Safety Administration 49 CFR Parts... AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), Department of Transportation (DOT... action allows pipeline operators to use current technologies, improved materials, and updated industry...

Development of national reference energy mean emission levels for the FHWA traffic noise model (FHWA TNM), version 1.0

DOT National Transportation Integrated Search

1995-11-01

Research and Special Programs Administration, John A. Volpe National Transportation Systems Center (Volpe Center), Acoustics Facility, in support of the Federal Highway Administration (FHWA) and 25 sponsoring state transportation agencies, conducted ...