Science.gov

Sample records for administrative actions occurring

  1. Administrative Actions for Noncompliance; Lesser Administrative Actions. Direct final rule.

    PubMed

    2016-04-01

    The Food and Drug Administration (FDA) is amending the regulation describing lesser administrative actions that may be imposed on an Institutional Review Board (IRB) that has failed to comply with FDA's IRB regulations. We are clarifying that FDA may require the IRB to withhold approval of new FDA-regulated studies, stop the enrollment of new subjects in ongoing studies, and terminate ongoing studies, or any combination of these actions until the noncompliance with FDA's IRB regulations is corrected. We are taking this action to ensure clarity and improve the accuracy of the regulations. PMID:27044118

  2. 15 CFR 752.16 - Administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Administrative actions. 752.16 Section... COMPREHENSIVE LICENSE § 752.16 Administrative actions. (a)(1) If BIS is not satisfied that you or other parties... parties to such licenses are not adequate, BIS may, in addition to any enforcement action pursuant to...

  3. 14 CFR 1275.106 - Administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Administrative actions. 1275.106 Section 1275.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RESEARCH MISCONDUCT § 1275.106 Administrative actions. (a) Listed in paragraphs (a)(1) through (a)(3) of this section...

  4. 14 CFR 1275.106 - Administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Administrative actions. 1275.106 Section 1275.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RESEARCH MISCONDUCT § 1275.106 Administrative actions. (a) Listed in paragraphs (a)(1) through (a)(3) of this section...

  5. 14 CFR 1275.106 - Administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Administrative actions. 1275.106 Section 1275.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RESEARCH MISCONDUCT § 1275.106 Administrative actions. (a) Listed in paragraphs (a)(1) through (a)(3) of this section...

  6. 14 CFR 1275.106 - Administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Administrative actions. 1275.106 Section 1275.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RESEARCH MISCONDUCT § 1275.106 Administrative actions. (a) Listed in paragraphs (a)(1) through (a)(3) of this section...

  7. 29 CFR 15.6 - Administrative action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Administrative action. 15.6 Section 15.6 Labor Office of the Secretary of Labor ADMINISTRATIVE CLAIMS UNDER THE FEDERAL TORT CLAIMS ACT AND RELATED STATUTES Claims Against the Government Under the Federal Tort Claims Act § 15.6 Administrative action. (a) Investigation. When an organizational unit learns...

  8. 29 CFR 15.6 - Administrative action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Administrative action. 15.6 Section 15.6 Labor Office of the... Against the Government Under the Federal Tort Claims Act § 15.6 Administrative action. (a) Investigation... such harm, it has the responsibility to fully investigate the incident and to take all...

  9. 24 CFR 25.5 - Administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... withdrawal, the mortgagee may file a new application for approval under 24 CFR part 202. (2) Effective date... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Administrative actions. 25.5... Development MORTGAGEE REVIEW BOARD § 25.5 Administrative actions. (a) General. The Board is authorized to...

  10. 42 CFR 93.200 - Administrative action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Administrative action. 93.200 Section 93.200 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  11. 42 CFR 93.200 - Administrative action.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Administrative action. 93.200 Section 93.200 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  12. Bladder Uptake of Liposomes after Intravesical Administration Occurs by Endocytosis

    PubMed Central

    Rajaganapathy, Bharathi Raja; Chancellor, Michael B.; Nirmal, Jayabalan; Dang, Loan; Tyagi, Pradeep

    2015-01-01

    Liposomes have been used therapeutically and as a local drug delivery system in the bladder. However, the exact mechanism for the uptake of liposomes by bladder cells is unclear. In the present study, we investigated the role of endocytosis in the uptake of liposomes by cultured human UROtsa cells of urothelium and rat bladder. UROtsa cells were incubated in serum-free media with liposomes containing colloidal gold particles for 2 h either at 37°C or at 4°C. Transmission Electron Microscopy (TEM) images of cells incubated at 37°C found endocytic vesicles containing gold inside the cells. In contrast, only extracellular binding was noticed in cells incubated with liposomes at 4°C. Absence of liposome internalization at 4°C indicates the need of energy dependent endocytosis as the primary mechanism of entry of liposomes into the urothelium. Flow cytometry analysis revealed that the uptake of liposomes at 37°C occurs via clathrin mediated endocytosis. Based on these observations, we propose that clathrin mediated endocytosis is the main route of entry for liposomes into the urothelial layer of the bladder and the findings here support the usefulness of liposomes in intravesical drug delivery. PMID:25811468

  13. 40 CFR 60.27 - Actions by the Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Actions by the Administrator. 60.27... Designated Facilities § 60.27 Actions by the Administrator. (a) The Administrator may, whenever he determines... receipt of a plan or plan revision, the Administrator will propose the plan or revision for approval...

  14. 40 CFR 60.27 - Actions by the Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Actions by the Administrator. 60.27... Designated Facilities § 60.27 Actions by the Administrator. (a) The Administrator may, whenever he determines... receipt of a plan or plan revision, the Administrator will propose the plan or revision for approval...

  15. 40 CFR 60.27 - Actions by the Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 7 2012-07-01 2012-07-01 false Actions by the Administrator. 60.27... Designated Facilities § 60.27 Actions by the Administrator. (a) The Administrator may, whenever he determines... receipt of a plan or plan revision, the Administrator will propose the plan or revision for approval...

  16. 40 CFR 60.27 - Actions by the Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 7 2013-07-01 2013-07-01 false Actions by the Administrator. 60.27... Designated Facilities § 60.27 Actions by the Administrator. (a) The Administrator may, whenever he determines... receipt of a plan or plan revision, the Administrator will propose the plan or revision for approval...

  17. 46 CFR 5.5 - Purpose of administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Purpose of administrative actions. 5.5 Section 5.5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE INVESTIGATION REGULATIONS-PERSONNEL ACTION Purpose § 5.5 Purpose of administrative actions. The...

  18. 46 CFR 5.5 - Purpose of administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Purpose of administrative actions. 5.5 Section 5.5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE INVESTIGATION REGULATIONS-PERSONNEL ACTION Purpose § 5.5 Purpose of administrative actions. The...

  19. 46 CFR 5.5 - Purpose of administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Purpose of administrative actions. 5.5 Section 5.5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE INVESTIGATION REGULATIONS-PERSONNEL ACTION Purpose § 5.5 Purpose of administrative actions. The...

  20. 36 CFR 906.5 - Administration of affirmative action plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 3 2012-07-01 2012-07-01 false Administration of affirmative action plan. 906.5 Section 906.5 Parks, Forests, and Public Property PENNSYLVANIA AVENUE DEVELOPMENT CORPORATION AFFIRMATIVE ACTION POLICY AND PROCEDURE Development Program § 906.5 Administration of affirmative action plan. (a) The developer...

  1. 46 CFR 5.5 - Purpose of administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Purpose of administrative actions. 5.5 Section 5.5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE INVESTIGATION REGULATIONS-PERSONNEL ACTION Purpose § 5.5 Purpose of administrative actions. The...

  2. 46 CFR 5.5 - Purpose of administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Purpose of administrative actions. 5.5 Section 5.5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC MARINE INVESTIGATION REGULATIONS-PERSONNEL ACTION Purpose § 5.5 Purpose of administrative actions. The...

  3. 15 CFR 922.50 - Appeals of administrative action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... § 922.50 Appeals of administrative action. (a)(1) Except for permit actions taken for enforcement reasons (see subpart D of 15 CFR part 904 for applicable procedures), an applicant for, or a holder of, a... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Appeals of administrative action....

  4. 15 CFR 922.50 - Appeals of administrative action.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... § 922.50 Appeals of administrative action. (a)(1) Except for permit actions taken for enforcement reasons (see subpart D of 15 CFR part 904 for applicable procedures), an applicant for, or a holder of, a... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Appeals of administrative action....

  5. 15 CFR 922.50 - Appeals of administrative action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... § 922.50 Appeals of administrative action. (a)(1) Except for permit actions taken for enforcement reasons (see subpart D of 15 CFR part 904 for applicable procedures), an applicant for, or a holder of, a... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Appeals of administrative action....

  6. 14 CFR 1245.115 - Action by the Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Action by the Administrator. 1245.115 Section 1245.115 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION PATENTS AND OTHER INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.115 Action by the Administrator. (a)...

  7. 14 CFR 1245.115 - Action by the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Action by the Administrator. 1245.115... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.115 Action by the Administrator. (a) After receiving the transmittal from the Board, the Administrator shall determine, in accordance with the...

  8. 14 CFR § 1245.115 - Action by the Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Action by the Administrator. § 1245.115... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.115 Action by the Administrator. (a) After receiving the transmittal from the Board, the Administrator shall determine, in accordance with the...

  9. 14 CFR 1245.115 - Action by the Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Action by the Administrator. 1245.115... INTELLECTUAL PROPERTY RIGHTS Patent Waiver Regulations § 1245.115 Action by the Administrator. (a) After receiving the transmittal from the Board, the Administrator shall determine, in accordance with the...

  10. 14 CFR § 1275.106 - Administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Administrative actions. § 1275.106 Section § 1275.106 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION RESEARCH MISCONDUCT § 1275.106 Administrative actions. (a) Listed in paragraphs (a)(1) through (a)(3) of this section...

  11. 36 CFR 906.5 - Administration of affirmative action plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CORPORATION AFFIRMATIVE ACTION POLICY AND PROCEDURE Development Program § 906.5 Administration of affirmative action plan. (a) The developer shall appoint an Affirmative Action Officer, and for projects exceeding $10 million in cost, the person appointed must have affirmative action as a primary responsibility....

  12. 36 CFR 906.5 - Administration of affirmative action plan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CORPORATION AFFIRMATIVE ACTION POLICY AND PROCEDURE Development Program § 906.5 Administration of affirmative action plan. (a) The developer shall appoint an Affirmative Action Officer, and for projects exceeding $10 million in cost, the person appointed must have affirmative action as a primary responsibility....

  13. 36 CFR 906.5 - Administration of affirmative action plan.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CORPORATION AFFIRMATIVE ACTION POLICY AND PROCEDURE Development Program § 906.5 Administration of affirmative action plan. (a) The developer shall appoint an Affirmative Action Officer, and for projects exceeding $10 million in cost, the person appointed must have affirmative action as a primary responsibility....

  14. 36 CFR 906.5 - Administration of affirmative action plan.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CORPORATION AFFIRMATIVE ACTION POLICY AND PROCEDURE Development Program § 906.5 Administration of affirmative action plan. (a) The developer shall appoint an Affirmative Action Officer, and for projects exceeding $10 million in cost, the person appointed must have affirmative action as a primary responsibility....

  15. 5 CFR 179.218 - Additional administrative collection action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Additional administrative collection action. 179.218 Section 179.218 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.218 Additional administrative collection...

  16. 5 CFR 179.218 - Additional administrative collection action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Additional administrative collection action. 179.218 Section 179.218 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CLAIMS COLLECTION STANDARDS Salary Offset § 179.218 Additional administrative collection...

  17. 40 CFR 72.96 - Administrator's action on compliance certifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Administrator's action on compliance certifications. 72.96 Section 72.96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Compliance Certification § 72.96 Administrator's action on compliance certifications. (a)...

  18. 40 CFR 73.84 - Administrator's action on applications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Administrator's action on applications. 73.84 Section 73.84 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Energy Conservation and Renewable Energy Reserve § 73.84 Administrator's action on applications....

  19. 40 CFR 72.96 - Administrator's action on compliance certifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Administrator's action on compliance certifications. 72.96 Section 72.96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Compliance Certification § 72.96 Administrator's action on compliance certifications. (a)...

  20. 40 CFR 72.96 - Administrator's action on compliance certifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Administrator's action on compliance certifications. 72.96 Section 72.96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Compliance Certification § 72.96 Administrator's action on compliance certifications. (a)...

  1. 25 CFR 248.10 - Appeals from administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Appeals from administrative actions. 248.10 Section 248.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER INDIAN IN-LIEU FISHING SITES § 248.10 Appeals from administrative actions. Any decision made...

  2. 25 CFR 248.10 - Appeals from administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Appeals from administrative actions. 248.10 Section 248.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER INDIAN IN-LIEU FISHING SITES § 248.10 Appeals from administrative actions. Any decision made...

  3. 25 CFR 248.10 - Appeals from administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Appeals from administrative actions. 248.10 Section 248.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER INDIAN IN-LIEU FISHING SITES § 248.10 Appeals from administrative actions. Any decision made...

  4. 25 CFR 248.10 - Appeals from administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Appeals from administrative actions. 248.10 Section 248.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER INDIAN IN-LIEU FISHING SITES § 248.10 Appeals from administrative actions. Any decision made by the...

  5. 7 CFR 1403.12 - Additional administrative collection action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 10 2013-01-01 2013-01-01 false Additional administrative collection action. 1403.12 Section 1403.12 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... PROCEDURES § 1403.12 Additional administrative collection action. Nothing contained in this part...

  6. 7 CFR 1403.12 - Additional administrative collection action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 10 2011-01-01 2011-01-01 false Additional administrative collection action. 1403.12 Section 1403.12 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... PROCEDURES § 1403.12 Additional administrative collection action. Nothing contained in this part...

  7. 7 CFR 1403.12 - Additional administrative collection action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 10 2014-01-01 2014-01-01 false Additional administrative collection action. 1403.12 Section 1403.12 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... PROCEDURES § 1403.12 Additional administrative collection action. Nothing contained in this part...

  8. 7 CFR 1403.12 - Additional administrative collection action.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 10 2012-01-01 2012-01-01 false Additional administrative collection action. 1403.12 Section 1403.12 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... PROCEDURES § 1403.12 Additional administrative collection action. Nothing contained in this part...

  9. 7 CFR 1403.12 - Additional administrative collection action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Additional administrative collection action. 1403.12 Section 1403.12 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY CREDIT... PROCEDURES § 1403.12 Additional administrative collection action. Nothing contained in this part...

  10. 40 CFR 72.96 - Administrator's action on compliance certifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Administrator's action on compliance certifications. 72.96 Section 72.96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Compliance Certification § 72.96 Administrator's action on compliance certifications. (a)...

  11. 15 CFR 766.25 - Administrative action denying export privileges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Administrative action denying export privileges. 766.25 Section 766.25 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS ADMINISTRATIVE...

  12. The Value Bases of Administrative Action.

    ERIC Educational Resources Information Center

    Hodgkinson, Christopher

    This paper proposes a method for understanding the relationships among the various value systems that underlie administrative thinking. The system takes into account the psychological faculties affecting ethical decisions, the philosophical orientations involved, and distinctions between the concepts of "right" and "good." The paper opens with…

  13. 77 FR 55492 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-10

    ...In compliance with section 202(c)(5) of the National Housing Act, this notice advises of the cause and description of administrative actions taken by HUD's Mortgagee Review Board against HUD-approved...

  14. 43 CFR 4.1287 - Action by administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... APPEALS PROCEDURES Special Rules Applicable to Surface Coal Mining Hearings and Appeals Appeals to the Board from Decisions of the Office of Surface Mining § 4.1287 Action by administrative law judge....

  15. 75 FR 43537 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ...In compliance with Section 202(c) of the National Housing Act, this notice advises of the cause and description of administrative actions taken by HUD's Mortgagee Review Board against HUD-approved...

  16. 43 CFR 4.1287 - Action by administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... APPEALS PROCEDURES Special Rules Applicable to Surface Coal Mining Hearings and Appeals Appeals to the Board from Decisions of the Office of Surface Mining § 4.1287 Action by administrative law judge....

  17. 76 FR 45594 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ...In compliance with Section 202(c)(5) of the National Housing Act, this notice advises of the cause and describes the administrative actions taken by HUD's Mortgagee Review Board against HUD-approved...

  18. 78 FR 21618 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-11

    ...In compliance with Section 202(c) (5) of the National Housing Act, this notice advises of the cause and description of administrative actions taken by HUD's Mortgagee Review Board against HUD-approved...

  19. 75 FR 81287 - Mortgagee Review Board: Administrative Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ...In compliance with Section 202(c) of the National Housing Act, this notice advises of the cause and description of administrative actions taken by HUD's Mortgagee Review Board against HUD-approved...

  20. 25 CFR 248.10 - Appeals from administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Appeals from administrative actions. 248.10 Section 248.10 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER INDIAN IN-LIEU FISHING SITES § 248.10 Appeals from administrative actions. Any decision made by the Area Director under this part 248 shall...

  1. Mechanisms of action of naturally occurring antibodies against β-amyloid on microglia

    PubMed Central

    2013-01-01

    Background Naturally occurring autoantibodies against amyloid-β (nAbs-Aβ) have been shown to exert beneficial effects on transgenic Alzheimer’s disease (AD) animals in vivo and on primary neurons in vitro. Not much is known about their effect on microglial cells. Our aim was to investigate the effect of nAbs-Aβ on amyloid-β (Aβ)-treated microglial cells in vitro with respect to cell viability, stress pathways, cytokine production and phagocytotic abilities and whether these effects can be conveyed to neurons. Methods Primary microglial cells isolated from Swiss Webster mouse mesencephalons on embryonic day 13.5 were pretreated with nAbs-Aβ and then treated with Aβ oligomers. After 3 hours, phagocytosis as well as western blot analysis were evaluated to measure the amount of phagocytized Aβ. Cell viability was analyzed using an MTT assay 24 hours after treatment. Pro-inflammatory cytokines in the supernatants were analyzed with ELISAs and then we treated primary neuronal cells with these conditioned microglia supernatants. Twenty-four hours later we did a MTT assay of the treated neurons. We further investigated the effect of a single nAbs-Aβ administration on Tg2576 mice in vivo. Results Upon co-administration of Aβ and nAbs-Aβ no change in microglia viability was observed. However, there was an increase in phosphorylated p38 protein level, an increase in the pro-inflammatory cytokines TNF-α and IL-6 and an increase in Aβ uptake by microglial cells. Treatment of primary neurons with conditioned microglia medium led to a 10% improvement in cell viability when nAbs-Aβ were co-administered compared to Aβ-treated cells alone. We were unable to detect changes in cytokine production in brain lysates of Tg2576 mice. Conclusions We provide evidence on the mechanism of action of nAbs-Aβ on microglia in vitro. Interestingly, our in vivo data indicate that nAbs-Aβ administration should be considered as a therapeutic strategy in AD, since there is no

  2. 43 CFR 4.439 - Action by administrative law judge.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Action by administrative law judge. 4.439 Section 4.439 Public Lands: Interior Office of the Secretary of the Interior DEPARTMENT HEARINGS AND APPEALS PROCEDURES Special Rules Applicable to Public Land Hearings and Appeals Hearings on Appeals Involving Questions of Fact § 4.439 Action...

  3. 32 CFR 513.3 - Administrative and punitive actions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Administrative and punitive actions. 513.3 Section 513.3 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS INDEBTEDNESS OF MILITARY PERSONNEL § 513.3 Administrative and...

  4. 15 CFR 756.2 - Appeal from an administrative action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Appeal from an administrative action. 756.2 Section 756.2 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS...

  5. 15 CFR 922.50 - Appeals of administrative action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Appeals of administrative action. 922.50 Section 922.50 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE...

  6. 15 CFR 922.50 - Appeals of administrative action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Appeals of administrative action. 922.50 Section 922.50 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT NATIONAL MARINE...

  7. 32 CFR 513.3 - Administrative and punitive actions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Administrative and punitive actions. 513.3 Section 513.3 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS INDEBTEDNESS OF MILITARY PERSONNEL § 513.3 Administrative and...

  8. Fetal radiation dose estimates for I-131 sodium iodide in cases where conception occurs after administration

    SciTech Connect

    Sparks, R.B.; Stabin, M.G.

    1999-01-01

    After administration of I-131 to the female patient, the possibility of radiation exposure of the embryo/fetus exists if the patient becomes pregnant while radioiodine remains in the body. Fetal radiation dose estimates for such cases were calculated. Doses were calculated for various maternal thyroid uptakes and time intervals between administration and conception, including euthyroid and hyperthyroid cases. The maximum fetal dose calculating was about 9.8E-03 mGy/MBq, which occurred with 100% maternal thyroid uptake and a 1 week interval between administration and conception. Placental crossover of the small amount of radioiodine remaining 90 days after conception was also considered. Such crossover could result in an additional fetal dose of 9.8E-05 mGy/MBq and a maximum fetal thyroid self dose of 3.5E-04 mGy/MBq.

  9. 42 CFR 8.34 - Court review of final administrative action; exhaustion of administrative remedies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Court review of final administrative action; exhaustion of administrative remedies. 8.34 Section 8.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures...

  10. 42 CFR 8.34 - Court review of final administrative action; exhaustion of administrative remedies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Court review of final administrative action; exhaustion of administrative remedies. 8.34 Section 8.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures...

  11. 42 CFR 8.34 - Court review of final administrative action; exhaustion of administrative remedies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Court review of final administrative action; exhaustion of administrative remedies. 8.34 Section 8.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures...

  12. 44 CFR 350.11 - Action by FEMA Regional Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Action by FEMA Regional Administrator. 350.11 Section 350.11 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS REVIEW AND APPROVAL OF STATE AND LOCAL RADIOLOGICAL...

  13. 44 CFR 350.11 - Action by FEMA Regional Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Action by FEMA Regional Administrator. 350.11 Section 350.11 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS REVIEW AND APPROVAL OF STATE AND LOCAL RADIOLOGICAL...

  14. 44 CFR 350.11 - Action by FEMA Regional Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Action by FEMA Regional Administrator. 350.11 Section 350.11 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS REVIEW AND APPROVAL OF STATE AND LOCAL RADIOLOGICAL...

  15. 45 CFR 689.8 - Interim administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ....8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION RESEARCH MISCONDUCT § 689.8 Interim administrative actions. (a) After an inquiry or during an external or... taken to protect Federal resources or to guard against continuation of any suspected or alleged...

  16. 45 CFR 689.8 - Interim administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ....8 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION RESEARCH MISCONDUCT § 689.8 Interim administrative actions. (a) After an inquiry or during an external or... taken to protect Federal resources or to guard against continuation of any suspected or alleged...

  17. Help Teachers Engage Students: Action Tools for Administrators

    ERIC Educational Resources Information Center

    Brinkman, Annette; Forlini, Gary; Williams, Ellen

    2009-01-01

    This unique, hands-on reference for school administrators offers guidelines for effective student engagement as well as reproducible action tools that will enable you to: (1) Identify and share "The Big Eight Student Engagement Strategies" with your teachers; (2) Promote teacher growth and provide support for new and/or struggling teachers; (3)…

  18. 45 CFR 689.8 - Interim administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... RESEARCH MISCONDUCT § 689.8 Interim administrative actions. (a) After an inquiry or during an external or... 2 CFR part 180, and the suspension procedures of 2 CFR part 180 will be followed, but the suspending... taken to protect Federal resources or to guard against continuation of any suspected or alleged...

  19. 45 CFR 689.8 - Interim administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RESEARCH MISCONDUCT § 689.8 Interim administrative actions. (a) After an inquiry or during an external or... 2 CFR part 180, and the suspension procedures of 2 CFR part 180 will be followed, but the suspending... taken to protect Federal resources or to guard against continuation of any suspected or alleged...

  20. 45 CFR 689.8 - Interim administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RESEARCH MISCONDUCT § 689.8 Interim administrative actions. (a) After an inquiry or during an external or... 2 CFR part 180, and the suspension procedures of 2 CFR part 180 will be followed, but the suspending... taken to protect Federal resources or to guard against continuation of any suspected or alleged...

  1. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false HHS administrative actions. 93.407 Section 93.407 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of...

  2. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.407 HHS administrative actions. (a) In response to a research misconduct proceeding... relevant Federal personnel policies and laws. (11) Suspension or debarment under 45 CFR Part 76, 48...

  3. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.407 HHS administrative actions. (a) In response to a research misconduct proceeding... relevant Federal personnel policies and laws. (11) Suspension or debarment under 45 CFR Part 76, 48...

  4. 42 CFR 93.407 - HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.407 HHS administrative actions. (a) In response to a research misconduct proceeding... relevant Federal personnel policies and laws. (11) Suspension or debarment under 45 CFR Part 76, 48...

  5. Institutional Image: The Concept and Implications for Administrative Action.

    ERIC Educational Resources Information Center

    Renihan, Frederick I; Renihan, Patrick J.

    1989-01-01

    Explores institutional image as a key to providing a philosophy and a logical foundation for school improvement efforts. Identifies two image dimensions (cosmetic and pastoral) and classifies five school types (synergistic, candy store, disaffected, monastic, and survivor), and discusses implications for administrative action. Includes three…

  6. Phytohormonal basis for the plant growth promoting action of naturally occurring biostimulators.

    PubMed

    Kurepin, Leonid V; Zaman, Mohammad; Pharis, Richard P

    2014-07-01

    There is increasing interest in the use of naturally occurring 'biostimulators' for enhancing the growth of agricultural and horticultural crops. Bacteria, fungi and protozoa, as well as marine algae-based seaweed extracts, can produce or contain biostimulators. The activity of biostimulators to promote plant growth is often attributed to their ability to directly or indirectly provide mineral nutrients (mostly N, but also P, S and other macro- and micro-nutrients) to plants. Alternatively, biostimulators are postulated to increase the plant's ability to assimilate these mineral nutrients, often in return for photo-assimilates (as occurs with certain bacteria and fungi associations). Although optimal growth of plants depends on the availability of adequate mineral nutritients, that growth (and also development, including reproduction) is also regulated by plant hormones (phytohormones), including gibberellins, auxins and cytokinins. This review describes and discusses the evidence that the presence or application of biostimulators also increases plant growth directly via phytohormone action and also influences the plant's ability to control its own hormone biosynthesis and homeostasis. Finally, it discusses the need for a better understanding of the role(s) that are played by the naturally occurring biostimulators associated with the plant in the crop field. It is suggested that better understanding will allow for optimal crop yield returns, since disruptions of phytohormone homeostasis in plant organs and tissues can yield either beneficial or sub-optimal outcomes. PMID:24375470

  7. 5 CFR 1201.142 - Actions filed by administrative law judges.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... complaint with the Board under this subpart. The filing and serving requirements of 5 CFR 1201.37 apply... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Actions filed by administrative law... Administrative Law Judges § 1201.142 Actions filed by administrative law judges. An administrative law judge...

  8. Transverse myelopathy occurring with intrathecal administration of methotrexate and cytarabine chemotherapy: A case report

    PubMed Central

    PAN, YING; WANG, CHUNHUAI; WANG, HUIPING; TAO, QIANSHAN; XIONG, SHUDAO; ZHAI, ZHIMIN

    2016-01-01

    Paraplegia following spinal injury is a rare complication subsequent to the administration of intrathecal chemotherapy; however, it is also one of the rare clinical features of central nervous system leukemia (CNSL). Distinguishing between the two is extremely important. The present study reports the case of a 46-year-old man who was diagnosed with acute lymphoblastic leukemia and subsequently achieved remission in the blood and bone marrow following the initial course of chemotherapy. However, the patient developed a sudden onset of paraplegia and urinary retention due to spinal cord infiltration of leukemia cells following the administration of intrathecal methotrexate and cytarabine. The paraplegia was initially reversible. However, a few weeks later, the patient developed irreversible paraplegia due to a complication of the intrathecal administration of chemotherapy (methotrexate and cytarabine arabinoside). The patient gave up further treatment in May 2013 and succumbed to the disease in June 2013. PMID:27313742

  9. Collaborative Developmental Action Inquiry: An Opportunity for Transformative Learning to Occur?

    ERIC Educational Resources Information Center

    Nicolaides, Aliki; Dzubinski, Leanne

    2016-01-01

    Life in the 21st century is increasingly complex, paradoxical, and ambiguous, bringing into question the ways that graduate adult education programs function. In this article, we describe an action research study involving the method of collaborative developmental action inquiry conducted with key stakeholders of a program in adult education at a…

  10. 40 CFR 300.820 - Administrative record file for a removal action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Administrative record file for a... SUBSTANCES POLLUTION CONTINGENCY PLAN Administrative Record for Selection of Response Action § 300.820 Administrative record file for a removal action. (a) If, based on the site evaluation, the lead agency...

  11. 40 CFR 23.2 - Timing of Administrator's action under Clean Water Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Timing of Administrator's action under Clean Water Act. 23.2 Section 23.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.2 Timing of Administrator's action under Clean Water Act. Unless the Administrator...

  12. 40 CFR 23.2 - Timing of Administrator's action under Clean Water Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Timing of Administrator's action under Clean Water Act. 23.2 Section 23.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.2 Timing of Administrator's action under Clean Water Act. Unless the Administrator...

  13. 40 CFR 23.2 - Timing of Administrator's action under Clean Water Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Timing of Administrator's action under Clean Water Act. 23.2 Section 23.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.2 Timing of Administrator's action under Clean Water Act. Unless the Administrator...

  14. 21 CFR 516.123 - Informal conferences regarding agency administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 6 2013-04-01 2013-04-01 false Informal conferences regarding agency administrative actions. 516.123 Section 516.123 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH....123 Informal conferences regarding agency administrative actions. (a) Should FDA make an...

  15. Bidirectional Synaptic Structural Plasticity after Chronic Cocaine Administration Occurs through Rap1 Small GTPase Signaling.

    PubMed

    Cahill, Michael E; Bagot, Rosemary C; Gancarz, Amy M; Walker, Deena M; Sun, HaoSheng; Wang, Zi-Jun; Heller, Elizabeth A; Feng, Jian; Kennedy, Pamela J; Koo, Ja Wook; Cates, Hannah M; Neve, Rachael L; Shen, Li; Dietz, David M; Nestler, Eric J

    2016-02-01

    Dendritic spines are the sites of most excitatory synapses in the CNS, and opposing alterations in the synaptic structure of medium spiny neurons (MSNs) of the nucleus accumbens (NAc), a primary brain reward region, are seen at early versus late time points after cocaine administration. Here we investigate the time-dependent molecular and biochemical processes that regulate this bidirectional synaptic structural plasticity of NAc MSNs and associated changes in cocaine reward in response to chronic cocaine exposure. Our findings reveal key roles for the bidirectional synaptic expression of the Rap1b small GTPase and an associated local synaptic protein translation network in this process. The transcriptional mechanisms and pathway-specific inputs to NAc that regulate Rap1b expression are also characterized. Collectively, these findings provide a precise mechanism by which nuclear to synaptic interactions induce "metaplasticity" in NAc MSNs, and we reveal the specific effects of this plasticity on reward behavior in a brain circuit-specific manner. PMID:26844834

  16. 25 CFR 162.241 - Will administrative fees be charged for actions relating to agricultural leases?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... INTERIOR LAND AND WATER LEASES AND PERMITS Agricultural Leases Lease Administration § 162.241 Will administrative fees be charged for actions relating to agricultural leases? (a) We will charge an administrative..., we will charge administrative fees based on the rent payable under the lease. The fee will be 3%...

  17. 25 CFR 162.241 - Will administrative fees be charged for actions relating to agricultural leases?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INTERIOR LAND AND WATER LEASES AND PERMITS Agricultural Leases Lease Administration § 162.241 Will administrative fees be charged for actions relating to agricultural leases? (a) We will charge an administrative..., we will charge administrative fees based on the rent payable under the lease. The fee will be 3%...

  18. 25 CFR 162.241 - Will administrative fees be charged for actions relating to agricultural leases?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INTERIOR LAND AND WATER LEASES AND PERMITS Agricultural Leases Lease Administration § 162.241 Will administrative fees be charged for actions relating to agricultural leases? (a) We will charge an administrative..., we will charge administrative fees based on the rent payable under the lease. The fee will be 3%...

  19. 25 CFR 162.241 - Will administrative fees be charged for actions relating to agricultural leases?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... INTERIOR LAND AND WATER LEASES AND PERMITS Agricultural Leases Lease Administration § 162.241 Will administrative fees be charged for actions relating to agricultural leases? (a) We will charge an administrative..., we will charge administrative fees based on the rent payable under the lease. The fee will be 3%...

  20. 25 CFR 162.241 - Will administrative fees be charged for actions relating to agricultural leases?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INTERIOR LAND AND WATER LEASES AND PERMITS Agricultural Leases Lease Administration § 162.241 Will administrative fees be charged for actions relating to agricultural leases? (a) We will charge an administrative..., we will charge administrative fees based on the rent payable under the lease. The fee will be 3%...

  1. 5 CFR 2430.13 - Exceptions to Administrative Law Judge's decision; briefs; action of Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Exceptions to Administrative Law Judge's... AWARDS OF ATTORNEY FEES AND OTHER EXPENSES § 2430.13 Exceptions to Administrative Law Judge's decision... administrative law judge's decision rendered pursuant to § 2430.12, and action by the Authority, shall be...

  2. Balancing RIF & Affirmative Action: A Guidebook for Administrators. Draft.

    ERIC Educational Resources Information Center

    Ruzicka, Pat; Berard, Barbara, Ed.

    The result of two seminars bringing together educators to discuss the "often conflicting requirements of affirmative action and reductions in force" (RIF), this booklet is intended to provide practical insights and suggestions on meeting affirmative action goals "in situations characterized by staff and program cutbacks." Chapter 1 describes…

  3. 40 CFR 23.2 - Timing of Administrator's action under Clean Water Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Timing of Administrator's action under Clean Water Act. 23.2 Section 23.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.2 Timing of Administrator's action under Clean...

  4. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity to contest findings of research misconduct and administrative actions. (a) Opportunity to contest....

  5. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity to contest findings of research misconduct and administrative actions. (a) Opportunity to contest....

  6. 40 CFR 23.2 - Timing of Administrator's action under Clean Water Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Timing of Administrator's action under Clean Water Act. 23.2 Section 23.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.2 Timing of Administrator's action under Clean...

  7. 25 CFR 247.21 - Can I appeal an administrative action?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can I appeal an administrative action? 247.21 Section 247.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.21 Can I appeal an administrative action? You may appeal...

  8. 25 CFR 247.21 - Can I appeal an administrative action?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Can I appeal an administrative action? 247.21 Section 247.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.21 Can I appeal an administrative action? You may appeal...

  9. 25 CFR 247.21 - Can I appeal an administrative action?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Can I appeal an administrative action? 247.21 Section 247.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.21 Can I appeal an administrative action? You may appeal...

  10. 25 CFR 247.21 - Can I appeal an administrative action?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Can I appeal an administrative action? 247.21 Section 247.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.21 Can I appeal an administrative action? You may appeal...

  11. 14 CFR 414.41 - Administrative law judge's recommended decision in safety approval actions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Administrative law judge's recommended decision in safety approval actions. 414.41 Section 414.41 Aeronautics and Space COMMERCIAL SPACE... Procedures § 414.41 Administrative law judge's recommended decision in safety approval actions. (a)...

  12. 14 CFR 414.41 - Administrative law judge's recommended decision in safety approval actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Administrative law judge's recommended decision in safety approval actions. 414.41 Section 414.41 Aeronautics and Space COMMERCIAL SPACE... Procedures § 414.41 Administrative law judge's recommended decision in safety approval actions. (a)...

  13. 14 CFR 414.41 - Administrative law judge's recommended decision in safety approval actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Administrative law judge's recommended decision in safety approval actions. 414.41 Section 414.41 Aeronautics and Space COMMERCIAL SPACE... Procedures § 414.41 Administrative law judge's recommended decision in safety approval actions. (a)...

  14. 14 CFR 414.41 - Administrative law judge's recommended decision in safety approval actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Administrative law judge's recommended decision in safety approval actions. 414.41 Section 414.41 Aeronautics and Space COMMERCIAL SPACE... Procedures § 414.41 Administrative law judge's recommended decision in safety approval actions. (a)...

  15. 40 CFR 77.4 - Administrator's action on proposed offset plans.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Administrator's action on proposed offset plans. 77.4 Section 77.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) EXCESS EMISSIONS § 77.4 Administrator's action on proposed offset plans....

  16. 40 CFR 78.6 - Action on petition for administrative review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Action on petition for administrative review. 78.6 Section 78.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) APPEAL PROCEDURES § 78.6 Action on petition for administrative review. (a) If...

  17. 40 CFR 23.3 - Timing of Administrator's action under Clean Air Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Timing of Administrator's action under Clean Air Act. 23.3 Section 23.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.3 Timing of Administrator's action under Clean Air...

  18. 40 CFR 23.3 - Timing of Administrator's action under Clean Air Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Timing of Administrator's action under Clean Air Act. 23.3 Section 23.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.3 Timing of Administrator's action under Clean Air...

  19. 40 CFR 23.3 - Timing of Administrator's action under Clean Air Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Timing of Administrator's action under Clean Air Act. 23.3 Section 23.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.3 Timing of Administrator's action under Clean Air...

  20. 40 CFR 23.3 - Timing of Administrator's action under Clean Air Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Timing of Administrator's action under Clean Air Act. 23.3 Section 23.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.3 Timing of Administrator's action under Clean Air...

  1. 40 CFR 23.3 - Timing of Administrator's action under Clean Air Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Timing of Administrator's action under Clean Air Act. 23.3 Section 23.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.3 Timing of Administrator's action under Clean Air...

  2. 40 CFR 23.7 - Timing of Administrator's action under Safe Drinking Water Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Timing of Administrator's action under Safe Drinking Water Act. 23.7 Section 23.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.7 Timing of Administrator's action under Safe Drinking Water Act. Unless...

  3. 40 CFR 23.7 - Timing of Administrator's action under Safe Drinking Water Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Timing of Administrator's action under Safe Drinking Water Act. 23.7 Section 23.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.7 Timing of Administrator's action under Safe Drinking Water Act. Unless...

  4. 40 CFR 23.7 - Timing of Administrator's action under Safe Drinking Water Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Timing of Administrator's action under Safe Drinking Water Act. 23.7 Section 23.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL JUDICIAL REVIEW UNDER EPA-ADMINISTERED STATUTES § 23.7 Timing of Administrator's action under Safe Drinking Water Act. Unless...

  5. 32 CFR 636.5 - Army administrative actions against intoxicated drivers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Army administrative actions against intoxicated drivers. 636.5 Section 636.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... INSTALLATIONS) Fort Stewart, Georgia § 636.5 Army administrative actions against intoxicated drivers. For...

  6. 32 CFR 636.5 - Army administrative actions against intoxicated drivers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Army administrative actions against intoxicated drivers. 636.5 Section 636.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... INSTALLATIONS) Fort Stewart, Georgia § 636.5 Army administrative actions against intoxicated drivers. For...

  7. 32 CFR 636.5 - Army administrative actions against intoxicated drivers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Army administrative actions against intoxicated drivers. 636.5 Section 636.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... INSTALLATIONS) Fort Stewart, Georgia § 636.5 Army administrative actions against intoxicated drivers. For...

  8. Nursing Academic Administrators' Lived Experiences With Incivility and Bullying From Faculty: Consequences and Outcomes Demanding Action.

    PubMed

    LaSala, Kathleen B; Wilson, Vicki; Sprunk, Elizabeth

    2016-01-01

    There are an increasing number of nursing academic administrators who identify themselves as victims of faculty incivility. This study examined experiences that academic administrators encountered with faculty incivility using a phenomenological research design. Three major themes emerged: faculty inappropriate behaviors, consequences of faculty behaviors on administrator targets, and administrators call for action. Findings revealed that incivility had devastating effects on administrators personally and professionally. PMID:26673315

  9. 32 CFR 634.12 - Army administrative actions against intoxicated drivers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... drivers. 634.12 Section 634.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... § 634.12 Army administrative actions against intoxicated drivers. Army commanders will take appropriate action against intoxicated drivers. These actions may include the following: (a) A written...

  10. 32 CFR 634.12 - Army administrative actions against intoxicated drivers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... drivers. 634.12 Section 634.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... § 634.12 Army administrative actions against intoxicated drivers. Army commanders will take appropriate action against intoxicated drivers. These actions may include the following: (a) A written...

  11. 32 CFR 634.12 - Army administrative actions against intoxicated drivers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... drivers. 634.12 Section 634.12 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... § 634.12 Army administrative actions against intoxicated drivers. Army commanders will take appropriate action against intoxicated drivers. These actions may include the following: (a) A written...

  12. 20 CFR 404.903 - Administrative actions that are not initial determinations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Administrative actions that are not initial determinations. 404.903 Section 404.903 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Determinations, Administrative Review Process, and Reopening of Determinations and...

  13. 21 CFR 1316.93 - Ruling on petition for expedited release in an administrative forfeiture action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Ruling on petition for expedited release in an administrative forfeiture action. 1316.93 Section 1316.93 Food and Drugs DRUG ENFORCEMENT ADMINISTRATION, DEPARTMENT OF JUSTICE ADMINISTRATIVE FUNCTIONS, PRACTICES, AND PROCEDURES Expedited Forfeiture Proceedings for Certain Property § 1316.93 Ruling...

  14. 12 CFR 623.6 - Duty to file information concerning adverse judicial or administrative action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Duty to file information concerning adverse judicial or administrative action. 623.6 Section 623.6 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM PRACTICE BEFORE THE FARM CREDIT ADMINISTRATION § 623.6 Duty to file information...

  15. 14 CFR 414.41 - Administrative law judge's recommended decision in safety approval actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Administrative law judge's recommended decision in safety approval actions. 414.41 Section 414.41 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING SAFETY APPROVALS Appeal Procedures § 414.41 Administrative law...

  16. 14 CFR 406.5 - Administrative law judge's recommended decision in license, permit, and payload actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Administrative law judge's recommended decision in license, permit, and payload actions. 406.5 Section 406.5 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURE INVESTIGATIONS, ENFORCEMENT, AND ADMINISTRATIVE...

  17. Administrative Leadership as Projection, Social Control, and Action.

    ERIC Educational Resources Information Center

    Reed, Donald B.

    Over the past 50 years, theoretical and methodological problems have plagued the study of leadership. This paper, proposing an alternative theory, argues that leadership has three fundamental components: projection and social control, which are linked by action. Projection is the visualization of a project to be completed. Educational…

  18. 40 CFR 73.84 - Administrator's action on applications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Energy Conservation and Renewable Energy Reserve § 73... categories of qualified renewable energy generation enumerated in § 73.81(c)(2)(i) and appendix A(3.1-3.4... conservation measures or renewable energy generation. (1) The Administrator will not award allowances to...

  19. 40 CFR 73.84 - Administrator's action on applications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Energy Conservation and Renewable Energy Reserve § 73... categories of qualified renewable energy generation enumerated in § 73.81(c)(2)(i) and appendix A(3.1-3.4... conservation measures or renewable energy generation.(1) The Administrator will not award allowances to...

  20. 40 CFR 73.84 - Administrator's action on applications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Energy Conservation and Renewable Energy Reserve § 73... categories of qualified renewable energy generation enumerated in § 73.81(c)(2)(i) and appendix A(3.1-3.4... conservation measures or renewable energy generation. (1) The Administrator will not award allowances to...

  1. 40 CFR 73.84 - Administrator's action on applications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Energy Conservation and Renewable Energy Reserve § 73... categories of qualified renewable energy generation enumerated in § 73.81(c)(2)(i) and appendix A(3.1-3.4... conservation measures or renewable energy generation.(1) The Administrator will not award allowances to...

  2. 40 CFR 97.428 - Administrator's action on submissions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Annual... conduct independent audits concerning any submission under the TR NOX Annual Trading Program and make appropriate adjustments of the information in the submission. (b) The Administrator may deduct TR NOX...

  3. 40 CFR 97.428 - Administrator's action on submissions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Annual... conduct independent audits concerning any submission under the TR NOX Annual Trading Program and make appropriate adjustments of the information in the submission. (b) The Administrator may deduct TR NOX...

  4. 40 CFR 97.428 - Administrator's action on submissions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAMS (CONTINUED) FEDERAL NOX BUDGET TRADING PROGRAM AND CAIR NOX AND SO2 TRADING PROGRAMS TR NOX Annual... conduct independent audits concerning any submission under the TR NOX Annual Trading Program and make appropriate adjustments of the information in the submission. (b) The Administrator may deduct TR NOX...

  5. Co-administration of Apelin and T4 Protects Inotropic and Chronotropic Changes Occurring in Hypothyroid Rats

    PubMed Central

    Akhondali, Zahra; Badavi, Mohammad; Dianat, Mahin; Faraji, Farzaneh

    2015-01-01

    Background One of the most important thyroid hormone targets is the cardiovascular system. Hemodynamic changes, such as decreased resting heart rate (HR), myocardial contractility, and cardiac output, and increased diastolic pressure and systemic vascular resistance, have been observed in hypothyroid patients. Moreover, in these patients, ECG changes include sinus bradycardia and low voltage complexes (P waves or QRS complexes). Objective This study aimed at evaluating the prophylactic effect of apelin on HR changes and QRS voltage that occur in propylthiouracil (PTU)-induced hypothyroid rats. Method In this study, 48 adult male Wistar rats weighing 170-235g were randomly divided into 6 groups: Control group (normal saline ip injection + tap water gavage); P group (PTU 0.05%, in drinking water); A group (apelin 200 µg.kg-1.day-1, ip); PA group [co-administration of PTU and apelin]; PT group [co-administration of PTU + T4 (0.2 mg/g per day, gavage)]; and PAT group (co-administration of PTU, apelin and T4). All experiments were performed for 28 consecutive days, and then the animals were anesthetized with an ip injection of ketamine (80 mg/kg) and xylazine (12 mg/kg). Lead II electrocardiogram was recorded to calculate HR and QRS voltage. Results Heart rate and QRS voltage increased more significantly in the hypothyroid group that consumed both apelin and T4 (201 ± 4 beat/min, 0.71 ± 0.02 mv vs. hypothyroid 145 ± 9 beat/min, 0.563 ± 0.015 mv; respectively). Conclusion The co-administration of apelin and T4 showed a protective effect on QRS voltage and HR in PTU‑induced hypothyroid rats. PMID:26247243

  6. 32 CFR 636.5 - Army administrative actions against intoxicated drivers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... INSTALLATIONS) Fort Stewart, Georgia § 636.5 Army administrative actions against intoxicated drivers. For this... content of 0.10 percent or higher as set forth in Official Code of Georgia Annotated 40-6-392(b)(3)....

  7. 32 CFR 636.5 - Army administrative actions against intoxicated drivers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... INSTALLATIONS) Fort Stewart, Georgia § 636.5 Army administrative actions against intoxicated drivers. For this... content of 0.10 percent or higher as set forth in Official Code of Georgia Annotated 40-6-392(b)(3)....

  8. 46 CFR 504.10 - Time constraints on final administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ENVIRONMENTAL POLICY ANALYSIS § 504.10 Time constraints on final administrative actions. No decision on a... reduced pursuant to 40 CFR 1506.10(d), or unless required by a statutorily-prescribed deadline on...

  9. 46 CFR 504.10 - Time constraints on final administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ENVIRONMENTAL POLICY ANALYSIS § 504.10 Time constraints on final administrative actions. No decision on a... reduced pursuant to 40 CFR 1506.10(d), or unless required by a statutorily-prescribed deadline on...

  10. 46 CFR 504.10 - Time constraints on final administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ENVIRONMENTAL POLICY ANALYSIS § 504.10 Time constraints on final administrative actions. No decision on a... reduced pursuant to 40 CFR 1506.10(d), or unless required by a statutorily-prescribed deadline on...

  11. 34 CFR 30.1 - What administrative actions may the Secretary take to collect a debt?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false What administrative actions may the Secretary take to collect a debt? 30.1 Section 30.1 Education Office of the Secretary, Department of Education DEBT COLLECTION General § 30.1 What administrative actions may the Secretary take to collect a debt? (a) The Secretary may take one or more of the...

  12. 25 CFR 247.21 - Can I appeal an administrative action?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Can I appeal an administrative action? 247.21 Section 247.21 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FISH AND WILDLIFE USE OF COLUMBIA RIVER TREATY FISHING ACCESS SITES § 247.21 Can I appeal an administrative action? You may appeal any decision made by the Area Director under this...

  13. 42 CFR 8.34 - Court review of final administrative action; exhaustion of administrative remedies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for... Withdrawal of Approval of an Accreditation Body § 8.34 Court review of final administrative...

  14. 42 CFR 8.34 - Court review of final administrative action; exhaustion of administrative remedies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HEALTH AND HUMAN SERVICES GENERAL PROVISIONS CERTIFICATION OF OPIOID TREATMENT PROGRAMS Procedures for... Withdrawal of Approval of an Accreditation Body § 8.34 Court review of final administrative...

  15. 10 CFR 205.199H - Actions not subject to administrative appeal.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 3 2010-01-01 2010-01-01 false Actions not subject to administrative appeal. 205.199H Section 205.199H Energy DEPARTMENT OF ENERGY OIL ADMINISTRATIVE PROCEDURES AND SANCTIONS Notice of Probable Violation, Remedial Order, Notice of Proposed Disallowance, and Order of Disallowance §...

  16. 14 CFR § 1240.110 - Recommendation to, and action by, the Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Recommendation to, and action by, the Administrator. § 1240.110 Section § 1240.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INVENTIONS AND CONTRIBUTIONS Awards for Scientific and Technical Contributions...

  17. 14 CFR 1240.110 - Recommendation to, and action by, the Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Recommendation to, and action by, the Administrator. 1240.110 Section 1240.110 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INVENTIONS AND CONTRIBUTIONS Awards for Scientific and Technical Contributions § 1240.110 Recommendation...

  18. 21 CFR 516.123 - Informal conferences regarding agency administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 6 2014-04-01 2014-04-01 false Informal conferences regarding agency administrative actions. 516.123 Section 516.123 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS NEW ANIMAL DRUGS FOR MINOR USE AND MINOR SPECIES Index of Legally...

  19. 20 CFR 658.702 - Initial action by the Regional Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Initial action by the Regional Administrator... investigation shall be extended 20 additional working days. (e) If the Regional Administrator determines that... MSFW Monitor Advocate. (f)(1) The State agency shall have 20 working days to comment on the...

  20. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  1. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  2. 14 CFR 406.5 - Administrative law judge's recommended decision in license, permit, and payload actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Administrative law judge's recommended decision in license, permit, and payload actions. 406.5 Section 406.5 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  3. 14 CFR 406.5 - Administrative law judge's recommended decision in license, permit, and payload actions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Administrative law judge's recommended decision in license, permit, and payload actions. 406.5 Section 406.5 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  4. 14 CFR 406.5 - Administrative law judge's recommended decision in license, permit, and payload actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Administrative law judge's recommended decision in license, permit, and payload actions. 406.5 Section 406.5 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  5. 14 CFR 406.5 - Administrative law judge's recommended decision in license, permit, and payload actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Administrative law judge's recommended decision in license, permit, and payload actions. 406.5 Section 406.5 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION...

  6. 21 CFR 1316.94 - Posting of substitute res in an administrative forfeiture action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Posting of substitute res in an administrative... Property § 1316.94 Posting of substitute res in an administrative forfeiture action. (a) Where property is... owner may obtain release of the property by posting a substitute res with the seizing agency....

  7. 19 CFR 171.54 - Substitute res in an administrative forfeiture action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Substitute res in an administrative forfeiture... Procedures § 171.54 Substitute res in an administrative forfeiture action. (a) Substitute res. Where property... of the property (the res) to obtain release of the property. The offer, which may be tendered at...

  8. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  9. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  10. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  11. Acquired tolerance to dilator action of hydrallazine during oral administration.

    PubMed Central

    Robinson, B F; Collier, J G; Dobbs, R J

    1980-01-01

    1 The effect on forearm blood flow of local intra-arterial infusion of hydrallazine has been studied in twelve patients with essential hypertension and six normal subjects. 2 When the patients with hypertension were not taking hydrallazine by mouth, they responded to intra-arterial infusions with a dose-dependent increase in forearm blood flow that was not significantly different from that in normal subjects. 3 When the patients were taking hydrallazine by mouth, the increase in forearm flow in response to intra-arterial infusions was reduced and forearm vascular resistance did not fall as low as it did in the control study (P less than 0.01). 4 In four patients, the response to intra-arterial hydrallazine was attenuated to a major extent, and in three of these, there was little or no response to oral treatment. In eight patients, the response to intra-arterial hydrallazine did not fall below one half of that in the control study and this minor reduction in sensitivity might be expected to impair, but not abolish, the response to oral treatment. 5 It is concluded that the resistance vessels commonly develop tolerance to the dilator action of hydrallazine during long-term oral therapy. In some patients a high degree of tolerance develops and this is an important cause of failure to respond to oral treatment. PMID:6769454

  12. Gait Changes Vary among Horses with Naturally Occurring Osteoarthritis Following Intra-articular Administration of Autologous Platelet-Rich Plasma

    PubMed Central

    Mirza, Mustajab H.; Bommala, Prakash; Richbourg, Heather A.; Rademacher, Nathalie; Kearney, Michael T.; Lopez, Mandi J.

    2016-01-01

    Mechanisms to reduce lameness associated with osteoarthritis (OA) are vital to equine health and performance. This study was designed to quantify response to autologous, intra-articular platelet-rich plasma (PRP) in horses with OA. Kinetic gait analysis was performed on 12 horses with unilateral forelimb lameness and OA in the same limb before and after intra-articular anesthesia (IAA). Radiographs and kinetic data were obtained before and 6 and 16 weeks after PRP administration to same joint, 4 weeks after IAA. Statistical evaluations included filtration effect on platelet concentration, relationship between kinetic variable changes after IAA versus PRP in the affected limb, and associations between response to PRP and response to IAA, platelet concentration, and radiographic OA. A positive response to IAA or PRP was defined as ≥5% improvement in peak vertical force, vertical impulse, or breaking impulse of the affected limb. Out of 10 horses that responded to IAA, 3 responded to PRP at both time points and 4 responded at one. Of the two horses that did not respond to IAA, one responded to PRP at both time points. Filtration increased platelet concentration significantly. The relationship between kinetic variable alterations of the affected limb after IAA and PRP was not significant, and response to PRP was not associated with response to IAA, platelet concentration, or radiographic OA. Changes in kinetic variables following IAA in joints with naturally occurring OA provide a custom standard to assess intra-articular therapy. Kinetic gait changes after intra-articular PRP are variable in horses with moderate to severe forelimb OA. PMID:27148544

  13. Gait Changes Vary among Horses with Naturally Occurring Osteoarthritis Following Intra-articular Administration of Autologous Platelet-Rich Plasma.

    PubMed

    Mirza, Mustajab H; Bommala, Prakash; Richbourg, Heather A; Rademacher, Nathalie; Kearney, Michael T; Lopez, Mandi J

    2016-01-01

    Mechanisms to reduce lameness associated with osteoarthritis (OA) are vital to equine health and performance. This study was designed to quantify response to autologous, intra-articular platelet-rich plasma (PRP) in horses with OA. Kinetic gait analysis was performed on 12 horses with unilateral forelimb lameness and OA in the same limb before and after intra-articular anesthesia (IAA). Radiographs and kinetic data were obtained before and 6 and 16 weeks after PRP administration to same joint, 4 weeks after IAA. Statistical evaluations included filtration effect on platelet concentration, relationship between kinetic variable changes after IAA versus PRP in the affected limb, and associations between response to PRP and response to IAA, platelet concentration, and radiographic OA. A positive response to IAA or PRP was defined as ≥5% improvement in peak vertical force, vertical impulse, or breaking impulse of the affected limb. Out of 10 horses that responded to IAA, 3 responded to PRP at both time points and 4 responded at one. Of the two horses that did not respond to IAA, one responded to PRP at both time points. Filtration increased platelet concentration significantly. The relationship between kinetic variable alterations of the affected limb after IAA and PRP was not significant, and response to PRP was not associated with response to IAA, platelet concentration, or radiographic OA. Changes in kinetic variables following IAA in joints with naturally occurring OA provide a custom standard to assess intra-articular therapy. Kinetic gait changes after intra-articular PRP are variable in horses with moderate to severe forelimb OA. PMID:27148544

  14. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Opportunity to contest findings of research... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity...

  15. 40 CFR 78.6 - Action on petition for administrative review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Action on petition for administrative review. 78.6 Section 78.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Appeals Board will issue an order under § 78.20(c) of this part. (b)(1) The Environmental Appeals...

  16. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Mitigating and aggravating factors in HHS administrative actions. 93.408 Section 93.408 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  17. 42 CFR 93.408 - Mitigating and aggravating factors in HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Mitigating and aggravating factors in HHS administrative actions. 93.408 Section 93.408 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON...

  18. 42 CFR 93.404 - Findings of research misconduct and proposed administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Findings of research misconduct and proposed administrative actions. 93.404 Section 93.404 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES...

  19. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Opportunity to contest findings of research misconduct and administrative actions. 93.501 Section 93.501 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH...

  20. 42 CFR 93.501 - Opportunity to contest findings of research misconduct and administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Opportunity to contest findings of research... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Opportunity To Contest ORI Findings of Research Misconduct and HHS Administrative Actions General Information § 93.501 Opportunity...

  1. 32 CFR 635.23 - DA Form 4833 (Commander's Report of Disciplinary or Administrative Action).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true DA Form 4833 (Commander's Report of Disciplinary or Administrative Action). 635.23 Section 635.23 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT...

  2. 42 CFR 456.524 - Notification of Administrator's action and duration of variance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... of variance. 456.524 Section 456.524 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Utilization Review Plans: FFP, Waivers, and Variances for Hospitals and Mental Hospitals Ur Plan: Remote Facility Variances from Time Requirements § 456.524 Notification of Administrator's action and duration...

  3. Attitudes of Faculty and Administrators Toward Affirmative Action in Higher Education; A Second Look.

    ERIC Educational Resources Information Center

    Maca, Suanne D.

    This dissertation investigated six indications of change regarding affirmative action efforts on the University of Texas at Austin campus since December, 1973. These indications of change were recorded in university personnel documents, EEO/AA Office records, and the results of a questionnaire submitted to the faculty and administrators of the…

  4. The relative advantages of criminal versus administrative environmental enforcement actions in Israel.

    PubMed

    Tal, Alon; Aharon, Yaara; Yuhas-Peled, Hadar

    2010-04-01

    Most environmental enforcement programs have separate criminal and administrative procedures for addressing violations. Pitting "criminal"versus"administrative" enforcement as mutually exclusive alternatives constitutes a "false dilemma". Clearly, the government response should be influenced by the severity of pollution and the specific circumstances of the polluter. Yet, policy makers seeking to improve environmental compliance need to have a clearer picture about the merits of each approach and their relative effectiveness. This research empirically assesses the effectiveness of criminal versus administrative enforcement activities in Israel. After considering the philosophical implications associated with each regulatory approach, the results of a year-long study are presented. A series of performance indicators are utilized, with particular weight on compliance status in the field, to assess the condition of environmental violations several years subsequent to completion of enforcement activities. The state of 100 violations of air, water and hazardous materials laws that had been addressed through the criminal process were matched with results of comparable violations, against which administrative actions were taken. Results suggest that while criminal enforcement is a longer process, compliance following these actions was significantly greater than in administrative enforcement cases. The findings also underline the significance of a systematic follow-up system for tracking violations after enforcement actions are complete. Finally, the study confirms the benefits of targeted assistance to improve compliance among violators of environmental standards. PMID:20383360

  5. Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration.

    PubMed

    Carnicella, Sebastien; He, Dao-Yao; Yowell, Quinn V; Glick, Stanley D; Ron, Dorit

    2010-10-01

    Ibogaine is a naturally occurring alkaloid that has been reported to decrease various adverse phenotypes associated with exposure to drugs of abuse and alcohol in human and rodent models. Unfortunately, ibogaine cannot be used as a medication to treat addiction because of severe side effects. Previously, we reported that the desirable actions of ibogaine to reduce self-administration of, and relapse to, alcohol consumption are mediated via the upregulation of the expression of the glial cell line-derived neurotrophic factor (GDNF) in the midbrain ventral tegmental area (VTA), and the consequent activation of the GDNF pathway. The ibogaine metabolite, noribogaine, and a synthetic derivative of ibogaine, 18-Methoxycoronaridine (18-MC), possess a similar anti-addictive profile as ibogaine in rodent models, but without some of its adverse side effects. Here, we determined whether noribogaine and/or 18-MC, like ibogaine, increase GDNF expression, and whether their site of action to reduce alcohol consumption is the VTA. We used SH-SY5Y cells as a cell culture model and found that noribogaine, like ibogaine, but not 18-MC, induces a robust increase in GDNF mRNA levels. Next, we tested the effect of intra-VTA infusion of noribogaine and 18-MC on rat operant alcohol self-administration and found that noribogaine, but not 18-MC, in the VTA decreases responding for alcohol. Together, our results suggest that noribogaine and 18-MC have different mechanisms and sites of action. PMID:21040239

  6. 31 CFR 363.45 - What are the rules for judicial and administrative actions involving securities held in...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... administrative actions involving securities held in TreasuryDirect ®? 363.45 Section 363.45 Money and Finance... Governing Securities Held in TreasuryDirect § 363.45 What are the rules for judicial and administrative actions involving securities held in TreasuryDirect ®? (a) Notice of adverse claim or pending...

  7. 31 CFR 363.45 - What are the rules for judicial and administrative actions involving securities held in...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... administrative actions involving securities held in TreasuryDirect ®? 363.45 Section 363.45 Money and Finance... Governing Securities Held in TreasuryDirect § 363.45 What are the rules for judicial and administrative actions involving securities held in TreasuryDirect ®? (a) Notice of adverse claim or pending...

  8. 31 CFR 363.45 - What are the rules for judicial and administrative actions involving securities held in...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... administrative actions involving securities held in TreasuryDirect ®? 363.45 Section 363.45 Money and Finance... Governing Securities Held in TreasuryDirect § 363.45 What are the rules for judicial and administrative actions involving securities held in TreasuryDirect ®? (a) Notice of adverse claim or pending...

  9. 31 CFR 363.45 - What are the rules for judicial and administrative actions involving securities held in...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... administrative actions involving securities held in TreasuryDirect ®? 363.45 Section 363.45 Money and Finance... Governing Securities Held in TreasuryDirect § 363.45 What are the rules for judicial and administrative actions involving securities held in TreasuryDirect ®? (a) Notice of adverse claim or pending...

  10. 40 CFR 23.8 - Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. 23.8 Section 23.8 Protection of Environment... Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. Unless the...

  11. 40 CFR 23.8 - Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. 23.8 Section 23.8 Protection of Environment... Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. Unless the...

  12. 40 CFR 23.8 - Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. 23.8 Section 23.8 Protection of Environment... Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. Unless the...

  13. 40 CFR 23.8 - Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. 23.8 Section 23.8 Protection of Environment... Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. Unless the...

  14. 40 CFR 23.8 - Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Timing of Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. 23.8 Section 23.8 Protection of Environment... Administrator's action under Uranium Mill Tailings Radiation Control Act of 1978. Unless the...

  15. 40 CFR 23.10 - Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act. 23.10 Section 23.10 Protection of Environment ENVIRONMENTAL... action under the Federal Food, Drug, and Cosmetic Act. Unless the Administrator otherwise...

  16. 40 CFR 23.10 - Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act. 23.10 Section 23.10 Protection of Environment ENVIRONMENTAL... action under the Federal Food, Drug, and Cosmetic Act. Unless the Administrator otherwise...

  17. 40 CFR 23.10 - Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act. 23.10 Section 23.10 Protection of Environment ENVIRONMENTAL... action under the Federal Food, Drug, and Cosmetic Act. Unless the Administrator otherwise...

  18. 40 CFR 23.10 - Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act. 23.10 Section 23.10 Protection of Environment ENVIRONMENTAL... action under the Federal Food, Drug, and Cosmetic Act. Unless the Administrator otherwise...

  19. 40 CFR 23.10 - Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Timing of Administrator's action under the Federal Food, Drug, and Cosmetic Act. 23.10 Section 23.10 Protection of Environment ENVIRONMENTAL... action under the Federal Food, Drug, and Cosmetic Act. Unless the Administrator otherwise...

  20. 7 CFR 1780.44 - Actions prior to loan or grant closing or start of construction, whichever occurs first.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... construction, whichever occurs first. 1780.44 Section 1780.44 Agriculture Regulations of the Department of... start of construction, whichever occurs first. (a) Applicants must provide evidence of adequate..., the processing office will authenticate the number of users. Ordinarily each signed user...

  1. 7 CFR 1780.44 - Actions prior to loan or grant closing or start of construction, whichever occurs first.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... water. (4) Lease agreements. Where the right of use or control of real property not owned by the... 7 Agriculture 12 2014-01-01 2013-01-01 true Actions prior to loan or grant closing or start of... Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) WATER AND WASTE...

  2. Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration

    PubMed Central

    Berkó, Szilvia; Szűcs, Kálmán F; Balázs, Boglárka; Csányi, Erzsébet; Varju, Gábor; Sztojkov-Ivanov, Anita; Budai-Szűcs, Mária; Bóta, Judit; Gáspár, Róbert

    2016-01-01

    Purpose Transdermal electroporation has become one of the most promising noninvasive methods for drug administration, with greatly increased transport of macromolecules through the skin. The cecal-contracting effects of repeated transdermal electroporation delivery and intravenous administration of neostigmine were compared in anesthetized rats. Methods The cecal contractions were detected with implantable strain gauge sensors, and the plasma levels of neostigmine were followed by high-performance liquid chromatography. Results Both intravenously and EP-administered neostigmine (0.2–66.7 μg/kg) increased the cecal contractions in a dose-dependent manner. For both the low doses and the highest dose, the neostigmine plasma concentrations were the same after the two modes of administration, while an insignificantly higher level was observed at a dose of 20 μg/kg after intravenous administration as compared with the electroporation route. The contractile responses did not differ significantly after the two administration routes. Conclusion The results suggest that electroporation-delivered neostigmine elicits action equivalent to that observed after intravenous administration as concerning both time and intensity. Electroporation permits the delivery of even lower doses of water-soluble compounds through the skin, which is very promising for clinical practice. PMID:27274203

  3. Oxaliplatin Immune-Induced Syndrome Occurs With Cumulative Administration and Rechallenge: Single Institution Series and Systematic Review Study.

    PubMed

    Bencardino, Katia; Mauri, Gianluca; Amatu, Alessio; Tosi, Federica; Bonazzina, Erica; Palmeri, Laura; Querques, Marialuisa; Ravera, Federica; Menegotto, Alberto; Boiani, Elisa; Sartore-Bianchi, Andrea; Siena, Salvatore

    2016-09-01

    Oxaliplatin immune-induced syndrome (OIIS) is an uncommon, potentially life-threatening, side effect associated with oxaliplatin-based chemotherapy. The present study reports 5 original cases of OIIS and systematically reviewed the available published cases. We retrospectively analyzed the clinical archives of the Niguarda Cancer Center from 2009 to 2015 and conducted a search for OIIS using the PubMed database, followed by deeper investigation of the references of the recorded studies. We pooled our series with other reported cases for systematic review in accordance with the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement using only English language as the selection criterion. A total of 61 OIIS cases were analyzed, the largest series reported to date. Of the 61 patients, 56 (91.8%) had received oxaliplatin for metastatic colorectal cancer. In 32 of the 61 patients (52.5%), OIIS was associated with grade 4 thrombocytopenia and in 4 (6.6%) with grade 4 anemia. OIIS was fatal in 4 patients. In 49 patients, oxaliplatin-induced immune system activation was tested using the Coombs test or by detection of antiplatelet antibodies and was positive in 87.7% of the patients. The average number of oxaliplatin cycles until the onset of OIIS was 16.7, and the number was significantly lower when oxaliplatin was administered as a rechallenge after a period of vacancy of treatment with this agent (4.6 cycles as rechallenge vs. 13.6 as first-time exposure; P < .00001). OIIS is triggered by cumulative administration of oxaliplatin, characteristically with a threefold earlier onset when the drug is administered as a rechallenge. Prompt identification of OIIS can be expected to reduce the risk of iatrogenic morbidity and mortality. PMID:26979913

  4. Antisecretory Action of the Extract of the Aerial Parts of Eremomastax speciosa (Acanthaceae) Occurs through Antihistaminic and Anticholinergic Pathways.

    PubMed

    André Perfusion, Amang; Tan, Paul V; Ernestine, Nkwengoua; Barthélemy, Nyasse

    2014-01-01

    Objective. The objective of this study was to find out the possible antiulcer mechanism of action of Eremomastax speciosa. Method. Carbachol- and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used in rats. Gastric mucosal ulceration, mucus production, pH, gastric volume, and acidity were measured. Results. Histamine and carbachol raised gastric acidity to 86.50 and 84.80 mEq/L, respectively, in the control rats, and the extracts (200 mg/kg) reduced gastric acidity to 34.60 and 39.00 mEq/L, respectively. Intraduodenal aqueous extract (400 mg/kg) in histamine- and carbachol-treated rats produced significant (P < 0.001) decreases in acid secretion to 28.50 and 28.80 mEq/L, respectively, and 100 percent inhibition of gastric ulceration. Augmented histamine-induced gastric acid secretion (90.20 mEq/L) was significantly reduced to 52.60 and 27.50 mEq/L by the 200 and 400 mg/kg doses of the aqueous extract, respectively. The extract significantly reduced (P < 0.001) the volume of gastric secretion and significantly increased mucus production. The ulcer inhibition potential of the extract significantly dropped to 25-44% (oral extract) and to 29-37% (duodenal extract) in carbachol/indomethacin-treated rats. Conclusion. The aqueous extract of E. speciosa has both cytoprotective and antisecretory effects. The antisecretory effect may involve a mechanism common to both cholinergic and histaminergic pathways. PMID:24695819

  5. Investigation of the mechanisms of action behind Electromotive Drug Administration (EMDA)

    PubMed Central

    Vásquez, Juan Luis; Miklavčič, Damijan; Hermann, Gregers G.G.; Gehl, Julie

    2016-01-01

    Objective Bladder cancer is a cause of considerable morbidity worldwide. Electromotive Drug Administration is a method that combines intravesical chemotherapy with local electric field application. Electroporation has been suggested among other mechanisms as having a possible role in the therapy, so the goal of the present study was to investigate the electric fields present in the bladder wall during the treatment to determine which mechanisms might be involved. Material and Methods Electromotive Drug Administration involves applying intravesical mitomycin C with direct current of 20 mA delivered through a catheter electrode for 30 min. For numerical electric field computation we built a 3-D nonhomogeneous patient specific model based on CT images and used finite element method simulations to determine the electric fields in the whole body. Results Results indicate that highest electric field in the bladder wall was 37.7 V/m. The mean electric field magnitude in the bladder wall was 3.03 V/m. The mean magnitude of the current density in the bladder wall was 0.61 A/m2. Conclusions The present study shows that electroporation is not the mechanism of action in EMDA. A more likely explanation of the mechanism of action is iontophoretic forces increasing the mitomycin C concentration in the bladder wall.

  6. 10 CFR 10.33 - Action by the Deputy Executive Director for Information Services and Administration and Chief...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Action by the Deputy Executive Director for Information... SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.33 Action by the Deputy Executive Director... Administration and Chief Information Officer or the Commission shall give due recognition to the favorable...

  7. 10 CFR 10.33 - Action by the Deputy Executive Director for Information Services and Administration and Chief...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Action by the Deputy Executive Director for Information... SECURITY INFORMATION OR AN EMPLOYMENT CLEARANCE Procedures § 10.33 Action by the Deputy Executive Director... Administration and Chief Information Officer or the Commission shall give due recognition to the favorable...

  8. Administrators in Action--Managing Public Monies and Processing Emotion in School Activities: A Teaching Case Study

    ERIC Educational Resources Information Center

    Tenuto, Penny L.; Gardiner, Mary E.; Yamamoto, Julie K.

    2015-01-01

    This teaching case describes school administrators in action performing day-to-day leadership tasks, managing public funds in school activities, and interacting with others appropriately. The case focuses on administrative challenges in handling and managing school activity funds. A method for processing emotion is discussed to assist…

  9. 14 CFR 11.21 - What are the most common kinds of rulemaking actions for which FAA follows the Administrative...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false What are the most common kinds of rulemaking actions for which FAA follows the Administrative Procedure Act? 11.21 Section 11.21 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL RULES...

  10. 20 CFR 418.3610 - Is there administrative or judicial review for administrative actions that are not initial...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...' Benefits SOCIAL SECURITY ADMINISTRATION MEDICARE SUBSIDIES Medicare Part D Subsidies Determinations and the... these sections. For example, changes in your prescription drug program or voluntary disenrollment in...

  11. Anxiolytic-like actions of buspirone in a runway model of intravenous cocaine self-administration

    PubMed Central

    Ettenberg, Aaron; Bernardi, Rick E.

    2007-01-01

    In previous work from our laboratory, rats traversing a straight alley for a reward of IV cocaine have been observed to develop ambivalence about entering the goal box. Over trials, animals repeatedly run toward the goal box, stop at the entry point, and then retreat back toward the start box. This unique pattern of retreat behavior has been shown to reflect a form of “approach-avoidance conflict” that stems from the subjects' concurrent positive (cocaine reward) and negative (cocaine-induced anxiety) associations with the goal box. Buspirone, a partial 5-HT1A agonist, has been reported to produce anxiolytic-like actions in the clinic, but has had mixed results in experimental tests of anxiety using animal subjects. Since most animal tests of conflict/anxiety employ the administration of foot-shock – a relatively strong aversive stimulus – it was of interest to determine whether buspirone would alter the more subtle approach-avoidance conflict observed in well-trained animals running a straight alley for single daily injections of 1.0 mg/kg IV cocaine. Runway testing consisted of single daily trials that continued until consistent approach-avoidance retreats were exhibited. Each animal was then pretreated 30 min prior to runway testing with vehicle and one of three doses of buspirone (0.0, 1.0, 2.5 or 5.0 mg/kg IP). Testing continued in a counterbalanced manner until all rats had experienced each dose of buspirone with 3 days of cocaine-only trials between each test day. The number of retreats exhibited on each trial served as an index of the approach-avoidance conflict present on that trial. Results clearly demonstrated that buspirone (at the two higher doses) attenuated the retreat behavior of animals approaching a goal-box for IV cocaine – an action consistent with its anxiolytic-like actions in the clinic. PMID:17064759

  12. The action of p-synephrine on hepatic carbohydrate metabolism and respiration occurs via both Ca(2+)-mobilization and cAMP production.

    PubMed

    de Oliveira, Andrea Luiza; Comar, Jurandir Fernando; de Sá-Nakanishi, Anacharis Babeto; Peralta, Rosane Marina; Bracht, Adelar

    2014-03-01

    Citrus aurantium extracts, which contain large amounts of p-synephrine, are widely used for weight loss purposes and as appetite suppressants. In the liver, C. aurantium (bitter orange) extracts affect hemodynamics, carbohydrate metabolism, and oxygen uptake. The purpose of the present work was to quantify the action of p-synephrine and also to obtain indications about its mechanism of action, a task that would be difficult to accomplish with C. aurantium extracts due to their rather complex composition. The experimental system was the isolated perfused rat liver. p-Synephrine significantly stimulated glycogenolysis, glycolysis, gluconeogenesis, and oxygen uptake. The compound also increased the portal perfusion pressure and the redox state of the cytosolic NAD(+)/NADH couple. A Ca(2+)-dependency for both the hemodynamic and the metabolic effects of p-synephrine was found. p-Synephrine stimulated both cAMP overflow and the initial Ca(2+) release from the cellular stores previously labeled with (45)Ca(2+). The metabolic and hemodynamic actions of p-synephrine were strongly inhibited by α-adrenergic antagonists and moderately affected by β-adrenergic antagonists. The results allow to conclude that p-synephrine presents important metabolic and hemodynamic effects in the liver. These effects can be considered as both catabolic (glycogenolysis) and anabolic (gluconeogenesis), they are mediated by both α- and β-adrenergic signaling, require the simultaneous participation of both Ca(2+) and cAMP, and could be contributing to the overall stimulation of metabolism that usually occurs during weight loss periods. PMID:24287564

  13. 31 CFR 363.45 - What are the rules for judicial and administrative actions involving securities held in...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... savings bond, or the registered owner of an undelivered gift security held in TreasuryDirect. ... administrative actions involving securities held in TreasuryDirect ®? 363.45 Section 363.45 Money and Finance... Governing Securities Held in TreasuryDirect § 363.45 What are the rules for judicial and...

  14. Philosophy of an Indian War: Indian Community Action in the Johnson Administration's War on Indian Poverty, 1964-1968.

    ERIC Educational Resources Information Center

    Cobb, Daniel M.

    1998-01-01

    Explores the Johnson administration's most provocative innovation, the Community Action Program (CAP), and how its philosophy of "maximum feasible participation" furthered tribal self-determination. Examines the long-term impacts of CAPs and other Office of Economic Opportunity initiatives related to Head Start, Rough Rock Demonstration School,…

  15. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of findings of research misconduct and HHS administrative actions. (a) When the ORI makes a finding...

  16. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of findings of research misconduct and HHS administrative actions. (a) When the ORI makes a finding...

  17. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Notifying the respondent of findings of research misconduct and HHS administrative actions. 93.405 Section 93.405 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC...

  18. 42 CFR 93.405 - Notifying the respondent of findings of research misconduct and HHS administrative actions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH MISCONDUCT Responsibilities of the U.S. Department of Health and Human Services Research Misconduct Issues § 93.405 Notifying the respondent of findings of research misconduct and HHS administrative actions. (a) When the ORI makes a finding...

  19. 10 CFR 10.33 - Action by the Deputy Executive Director for Information Services and Administration and Chief...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Action by the Deputy Executive Director for Information Services and Administration and Chief Information Officer. 10.33 Section 10.33 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO RESTRICTED DATA OR NATIONAL SECURITY INFORMATION OR AN...

  20. 10 CFR 2.110 - Filing and administrative action on submittals for standard design approval or early review of...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... standard design approval or early review of site suitability issues. 2.110 Section 2.110 Energy NUCLEAR... administrative action on submittals for standard design approval or early review of site suitability issues. (a... chapter, a submittal for early review of site suitability issues under appendix Q to parts 50 of...

  1. 10 CFR 2.110 - Filing and administrative action on submittals for standard design approval or early review of...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... standard design approval or early review of site suitability issues. 2.110 Section 2.110 Energy NUCLEAR... administrative action on submittals for standard design approval or early review of site suitability issues. (a... chapter, a submittal for early review of site suitability issues under appendix Q to parts 50 of...

  2. 10 CFR 2.110 - Filing and administrative action on submittals for standard design approval or early review of...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Filing and administrative action on submittals for standard design approval or early review of site suitability issues. 2.110 Section 2.110 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Procedure for Issuance, Amendment, Transfer, or...

  3. 76 FR 56452 - Proposed Administrative Settlement Agreement and Order on Consent for Removal Action for 6472...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... Agreement and Order on Consent for Removal Action (``AOC'') for a removal action at the 6472 Selkirk Avenue... approval of EPA and the U.S. Department of Justice. The proposed AOC relates to the removal action at the.... 9604(a)(1). EPA is negotiating the proposed AOC pursuant to its authority under Section 122 of...

  4. 21 CFR 1316.92 - Petition for expedited release in an administrative forfeiture action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Administration (DEA) or Federal Bureau of Investigation (FBI) field office in the judicial district in which the... the Director of the FBI or to the Administrator of the DEA, depending upon which agency seized...

  5. 21 CFR 1316.92 - Petition for expedited release in an administrative forfeiture action.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Administration (DEA) or Federal Bureau of Investigation (FBI) field office in the judicial district in which the... the Director of the FBI or to the Administrator of the DEA, depending upon which agency seized...

  6. 20 CFR 1002.167 - What actions may a plan administrator take if the employee does not elect or pay for continuing...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What actions may a plan administrator take if... Uniformed Services Health Plan Coverage § 1002.167 What actions may a plan administrator take if the... may take regarding the provision or cancellation of an employee's continuing coverage depend...

  7. Streamlining Administrative Procedures at the Defense Language Institute: The Strategic Impact Model in Action

    ERIC Educational Resources Information Center

    Oded, Yaniv; Su, Bude

    2010-01-01

    Performance at the Defense Language Institute was examined through the prism of human performance technology and the strategic impact model. This examination revealed performance deficiencies in the administrative realm that required mainly a noninstructional intervention. A systematic analysis showed that digitizing administrative procedures…

  8. 20 CFR 408.1004 - Which administrative actions are not initial determinations?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... include, but are not limited to, an action about— (a) Denial of a request to be made your representative... federally administered State recognition payments due to a State-initiated mass change, as defined in §...

  9. 20 CFR 408.1004 - Which administrative actions are not initial determinations?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... include, but are not limited to, an action about— (a) Denial of a request to be made your representative... federally administered State recognition payments due to a State-initiated mass change, as defined in §...

  10. 20 CFR 408.1004 - Which administrative actions are not initial determinations?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... include, but are not limited to, an action about— (a) Denial of a request to be made your representative... federally administered State recognition payments due to a State-initiated mass change, as defined in §...

  11. 20 CFR 408.1004 - Which administrative actions are not initial determinations?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... include, but are not limited to, an action about— (a) Denial of a request to be made your representative... federally administered State recognition payments due to a State-initiated mass change, as defined in §...

  12. 20 CFR 408.1004 - Which administrative actions are not initial determinations?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... include, but are not limited to, an action about— (a) Denial of a request to be made your representative... federally administered State recognition payments due to a State-initiated mass change, as defined in §...

  13. 17 CFR 14.9 - Duty to file information concerning adverse judicial or administrative action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... action instituted by the Commission, shall promptly file a copy of the relevant order, judgment or decree....7 and who has not filed a copy of the order, judgment or decree within thirty days after its...

  14. Handbook for Faculty: A Digest of Faculty and Administrative Actions. DePauw University.

    ERIC Educational Resources Information Center

    Shumaker, Arthur W.; Farber, Robert H.

    DePauw University organization, policies, and faculty benefits are presented in the 1971 faculty handbook. Included are descriptions of administrator responsibilities, including department heads, faculty leave and tenure regulations, and academic standards. (JT)

  15. Naturally Occurring Food Toxins

    PubMed Central

    Dolan, Laurie C.; Matulka, Ray A.; Burdock, George A.

    2010-01-01

    Although many foods contain toxins as a naturally-occurring constituent or, are formed as the result of handling or processing, the incidence of adverse reactions to food is relatively low. The low incidence of adverse effects is the result of some pragmatic solutions by the US Food and Drug Administration (FDA) and other regulatory agencies through the creative use of specifications, action levels, tolerances, warning labels and prohibitions. Manufacturers have also played a role by setting limits on certain substances and developing mitigation procedures for process-induced toxins. Regardless of measures taken by regulators and food producers to protect consumers from natural food toxins, consumption of small levels of these materials is unavoidable. Although the risk for toxicity due to consumption of food toxins is fairly low, there is always the possibility of toxicity due to contamination, overconsumption, allergy or an unpredictable idiosyncratic response. The purpose of this review is to provide a toxicological and regulatory overview of some of the toxins present in some commonly consumed foods, and where possible, discuss the steps that have been taken to reduce consumer exposure, many of which are possible because of the unique process of food regulation in the United States. PMID:22069686

  16. 20 CFR 416.1402 - Administrative actions that are initial determinations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... supplemental security income benefits or your special SSI cash benefits under § 416.262, except actions solely...)). (b) Suspension, reduction, or termination of your SSI benefits or special SSI cash benefits (see §§ 416.261 and 416.262) or suspension or termination of your special SSI eligibility status (see §§...

  17. 20 CFR 416.1403 - Administrative actions that are not initial determinations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., an action about— (1) Presumptive disability or presumptive blindness; (2) An emergency advance... supplementary payments due to a State-initiated mass change, as defined in § 416.1401, in the levels of such... a receipt in response to your report of a change in your earned income. (b) We send some notices...

  18. Using Participatory Action Research and Photo Methods to Explore Higher Education Administration as an Emotional Endeavor

    ERIC Educational Resources Information Center

    Gonzales, Leslie D.; Rincones, Rodolfo

    2013-01-01

    In this paper, we build on Wood's (2010, 2012) recent call to consider higher education as a work place that conjures emotion among constituents, particularly positional leaders, like department chairs. Using a participatory action research and photo-enhanced methodological approach, we illustrate the emotional labor that was poured into the…

  19. Emergency Department Administration of Thienopyridines in NSTEMI: Results from the ACTION Registry®-GWTG™ Registry

    PubMed Central

    Diercks, Deborah B.; Kontos, Michael C.; Hollander, Judd E.; Mumma, Bryn E.; Holmes, DaJuanicia N.; Wiviott, Stephen; Saucedo, Jorge F.; de Lemos, James A.

    2014-01-01

    Objective AHA/ACC guidelines recommend that patients with definite unstable angina or non-ST segment elevation myocardial infarction (NSTEMI) receive dual antiplatelet therapy on presentation to the hospital when undergoing early invasive management or “as soon as possible” after admission when being managed conservatively. The guidelines do not specify whether these medications should be administered in the emergency department (ED). Our aim was to determine whether ED administration of a thienopyridine was associated with clinical outcomes among patients with NSTEMI. Methods We examined thienopyridine use in 39,454 patients with NSTEMI who received a thienopyridine within 24 hours of presentation in the NCDR’s ACTIONRegistry®-GWTG™ from 1/2007–6/2010. Patients who were not seen initially in the ED, were transferred in, or were missing time data were excluded. We analyzed the association between ED administration of thienopyridines and outcomes and patient demographics. Results Of the cohort receiving a thienopyridine within 24 hours, 9534 (24.2%) received it in the ED. ED administration of a thienopyridine was not associated with in-hospital major bleeding (multivariable adjusted OR 0.99; 95% confidence interval [CI]: 0.91–1.09) or in-hospital mortality (adjusted 1.02, 95% CI 0.86–1.20). Independent predictors most strongly associated with ED thienopyridine administration were elevated troponin, ED length of stay, prior percutaneous coronary intervention, and initial electrocardiogram showing ischemic changes. Conclusions There was no association between ED thienopyridine administration and in-hospital major bleeding or mortality. ED length of stay, ECG changes and elevated troponin were associated with ED thienopyridine administration. PMID:23702070

  20. 23 CFR 810.208 - Action by the Federal Highway Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Section 810.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass... carried on in accordance with 23 U.S.C. 134 as described under 23 CFR part 450, subpart A....

  1. 23 CFR 810.208 - Action by the Federal Highway Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Section 810.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass... carried on in accordance with 23 U.S.C. 134 as described under 23 CFR part 450, subpart A....

  2. 23 CFR 810.208 - Action by the Federal Highway Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Section 810.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass... carried on in accordance with 23 U.S.C. 134 as described under 23 CFR part 450, subpart A....

  3. 23 CFR 810.208 - Action by the Federal Highway Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Section 810.208 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PUBLIC TRANSPORTATION MASS TRANSIT AND SPECIAL USE HIGHWAY PROJECTS Making Highway Rights-of-Way Available for Mass... carried on in accordance with 23 U.S.C. 134 as described under 23 CFR part 450, subpart A....

  4. How Administrators Can Improve Teaching: Moving from Talk to Action in Higher Education.

    ERIC Educational Resources Information Center

    Seldin, Peter; And Others

    This collection of 11 papers focuses on the strategies and programs college administrators can use to effect changes needed to achieve teaching excellence. Most papers combine a review of the research and professional literature with the author's personal experience. The first part of the book examines the college and university climate and the…

  5. Administrators' Professional Learning via Twitter: The Dissonance between Beliefs and Actions

    ERIC Educational Resources Information Center

    Cho, Vincent

    2016-01-01

    Purpose: Although there has been increasing optimism about the potential for social media platforms such as Twitter to support educators' professional learning, it is yet unclear whether such promises hold true. Accordingly, the purpose of this paper is to explore school administrators' use of Twitter for professional learning.…

  6. 7 CFR 246.18 - Administrative review of State agency actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... SERVICE, DEPARTMENT OF AGRICULTURE CHILD NUTRITION PROGRAMS SPECIAL SUPPLEMENTAL NUTRITION PROGRAM FOR... review procedures. The State agency must develop procedures for a full administrative review of the... listed in paragraph (a)(1)(ii) of this section, the State agency must develop procedures for...

  7. 24 CFR 103.410 - Election of civil action or provision of administrative proceeding.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... administrative proceeding under 24 CFR part 180, to have the claims asserted in the charge decided in a civil... accordance with the procedures established under 24 CFR part 180. (c) If an election is not made under this... with the procedures under 24 CFR part 180. (d) If an election is made under this section, the...

  8. 24 CFR 103.410 - Election of civil action or provision of administrative proceeding.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... administrative proceeding under 24 CFR part 180, to have the claims asserted in the charge decided in a civil... accordance with the procedures established under 24 CFR part 180. (c) If an election is not made under this... with the procedures under 24 CFR part 180. (d) If an election is made under this section, the...

  9. 29 CFR 102.48 - Action of the Board upon expiration of time to file exceptions to the administrative law judge's...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to file exceptions to the administrative law judge's decision; decisions by the Board; extraordinary... 29 Labor 2 2010-07-01 2010-07-01 false Action of the Board upon expiration of time to file exceptions to the administrative law judge's decision; decisions by the Board; extraordinary...

  10. Large perceptual distortions of locomotor action space occur in ground-based coordinates: Angular expansion and the large-scale horizontal-vertical illusion.

    PubMed

    Klein, Brennan J; Li, Zhi; Durgin, Frank H

    2016-04-01

    What is the natural reference frame for seeing large-scale spatial scenes in locomotor action space? Prior studies indicate an asymmetric angular expansion in perceived direction in large-scale environments: Angular elevation relative to the horizon is perceptually exaggerated by a factor of 1.5, whereas azimuthal direction is exaggerated by a factor of about 1.25. Here participants made angular and spatial judgments when upright or on their sides to dissociate egocentric from allocentric reference frames. In Experiment 1, it was found that body orientation did not affect the magnitude of the up-down exaggeration of direction, suggesting that the relevant orientation reference frame for this directional bias is allocentric rather than egocentric. In Experiment 2, the comparison of large-scale horizontal and vertical extents was somewhat affected by viewer orientation, but only to the extent necessitated by the classic (5%) horizontal-vertical illusion (HVI) that is known to be retinotopic. Large-scale vertical extents continued to appear much larger than horizontal ground extents when observers lay sideways. When the visual world was reoriented in Experiment 3, the bias remained tied to the ground-based allocentric reference frame. The allocentric HVI is quantitatively consistent with differential angular exaggerations previously measured for elevation and azimuth in locomotor space. (PsycINFO Database Record PMID:26594884

  11. Effects of synthetic and naturally occurring flavonoids on Na sup + , K sup + -ATPase: Aspects of the structure-activity relationship and action mechanism

    SciTech Connect

    Hirano, T.; Oka, K.; Akiba, M. )

    1989-01-01

    A comparative study was made of the effects of 15 synthetic and naturally occurring flavonoids on the hydrolytic activity of Na{sup +}, K{sup +} -adenosine triphosphatase (ATPase). Twelve of the flavonoids examined were mono-hydroxy or mono-methoxy derivatives. All inhibited Na{sup +}, K{sup +} -ATPase from dog kidney cortex when present at concentrations from 40-1000 {mu}M. Flavones possessing cyclohexyl instead of the phenyl group were the most potent with IC{sub 50} at 257-320 {mu}M. Structure-activity relationships were observed among the following mono-substituted flavones as: (i) 2-cyclohexyl-benzopyran-4-one {much gt} 2-phenyl-benzopyran-4-one; (ii) 2-cyclohexyl-7-hydroxybenzopyran-4-one {gt} 2-cyclohexyl-6-hydroxy-benzopyran-4-one {gt} 2-cyclohexyl-5-hydroxybenzopyran-4-one. Some flavonoids showing potent inhibitory activity were also examined for ouabain-displacement activity on human erythrocytes. Hardly and of the flavonoids were able to block ({sup 3}H) ouabain binding to erythrocytes. These results suggest that the mechanism by which flavonoid block Na{sup +}, K{sup +} -ATPase is not related to the cardiac glycoside-specific binding site(s) of this enzyme.

  12. 7 CFR 356.4 - Property valued at $10,000 or less; notice of seizure administrative action to obtain forfeiture.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 5 2012-01-01 2012-01-01 false Property valued at $10,000 or less; notice of seizure administrative action to obtain forfeiture. 356.4 Section 356.4 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...

  13. Enterohepatic circulation, urinary excretion and laxative action of some bisacodyl derivatives after intragastric administration in the rat.

    PubMed

    Sund, R B; Songedal, K; Harestad, T; Salvesen, B; Kristiansen, S

    1981-01-01

    Bisacodyl (BIS), the parent diphenol (DES) and its sulphuric acid di-ester (picosulphate = PICO) were given by stomach tube to fasted rats at a dose of 3.1 mumol/100 g rat. Bile was sampled in the periods 0-6, 6-12 and 12-18 hrs after drug administration, and assayed for total diphenol (= free + conjugated) by HPLC. Mean fractions (% of dose +/- S.E.M.) excreted in 5 rats per compound and period were: BIS 74.0 +/- 4.7, 51.9 +/- 7.9 and 30.8 +/- 2.5; DES 41.2 +/-4.3, 46.8 +/- 4.7 and 25.1 +/- 2.5; PICO 9.0 +/- 0.9, 26.0 +/- 5.4 and 19.6 +/- 3.1. Only minor amounts were excreted as free diphenol. Urine samples taken by bladder puncture and assayed as above furthermore showed that the renal excretion of total diphenol was insignificant compared to the amounts excreted in bile. Practically no diphenol was present in urine 0-6 hrs after the administration of PICO. In experiments with BIS and DES at 0.85 mumol/100 g, total diphenol excreted in bile during 0-6 hrs was: BIS 67.1 +/- 2.6 (n = 5); DES: 55.4 +/- 3.0 (5). - The latency time for laxative effect was studied in groups of 10 unfasted rats per compound. cumulative time response curves showed that PICO caused diarrhoea more promptly at 0.85 mumol/100 g than either BIS or DES. In most rats, this delayed action of BIS and DES persisted also at 1.7 mumol/100 g. At 3.1 mumol/100 g, however, the majority of the rats reacted as promptly to these two compounds as to PICO. These results are discussed in relation to the biliary excretion experiments, and interpreted in terms of the relative importance at the different dose levels of: 1. The enterohepatic recirculated fraction, and 2. The non-absorbed fraction, which passes directly to the large intestine. For PICO, the latter fraction is the single determinant of the effect, which is triggered when the di-ester is being hydrolyzed to active diphenol in this part of the GI-tract. PMID:7223440

  14. Antinociceptive action of diphenyl diselenide in the nociception induced by neonatal administration of monosodium glutamate in rats.

    PubMed

    Rosa, Suzan G; Quines, Caroline B; da Rocha, Juliana T; Bortolatto, Cristiani F; Duarte, Thiago; Nogueira, Cristina W

    2015-07-01

    Monosodium glutamate (MSG) is a neuroexcitatory amino acid commonly used as flavoring of foods. MSG neonatal administration to animals leads to behavioral and physiological disorders in adulthood, including increased pain sensitivity. This study aimed to investigate the effect of diphenyl diselenide (PhSe)2, an organoselenium compound with pharmacological properties already documented, on nociception induced by MSG. Newborn Wistar rats received 10 subcutaneous injections of MSG at a dose of 4.0g/kg or saline (once daily). At the 60th day of life, the rats were daily treated with (PhSe)2 (1mg/kg) or vehicle (canola oil) by the intragastric route for 7 days. The behavioral tests (locomotor activity, hot plate, tail-immersion and mechanical allodynia) were carried out. Ex vivo assays were performed in samples of hippocampus to determine Na(+), K(+)-ATPase and Ca(2+)-ATPase activities, cytokine levels and [(3)H]glutamate uptake. The results demonstrated that MSG increased nociception in the hot plate test and in the mechanical allodynia stimulated by Von-Frey hair but did not alter the tail immersion test. (PhSe)2 reversed all nociceptive behaviors altered by MSG. MSG caused an increase in Na(+),K(+)-ATPase and Ca(2+)-ATPase activities and in pro-inflammatory cytokine levels and a decrease in the anti-inflammatory cytokine and in the [(3)H]glutamate uptake. (PhSe)2 was effective in reversing all alterations caused by MSG. The results indicate that (PhSe)2 had a potential antinociceptive and anti-inflammatory action in the MSG model. PMID:25841878

  15. 41 CFR 105-68.610 - What procedures does the General Services Administration use in suspension and debarment actions?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What procedures does the... Public Contracts and Property Management Federal Property Management Regulations System (Continued..., consistent with principles of fundamental fairness. (a) For suspension actions, we use the procedures in...

  16. The action of humidified gas on the pulmonary lining layer. Ultrastructural observations after administration of pure oxygen and of various mixtures of oxygen and carbon dioxide.

    PubMed

    Baratta, L; Baratta, B; Castellani, P; Strazzer, F

    1979-10-15

    The study concerns the action of dehumidified or humidified gas on the pulmonary lining layer. The results of our research suggest that water vapor used in artificial ventilation may be an important determining factor of the respiratory problems reported by clinicians in man. Important modifications of the lining layer of the alveolar epithelium occur, accompanied by more important alterations, including those of the content of the alveolus, all of which contribute to the pulmonary edema observed. PMID:122059

  17. An Action-Oriented Perspective on Caring Leadership: A Qualitative Study of Higher Education Administrators' Positive Leadership Experiences

    ERIC Educational Resources Information Center

    Uusiautti, Satu

    2013-01-01

    Interest in human experiences, especially positive experiences, has been increasing ever since positive psychology gained a foothold in public attention. In this research, higher education administrators from Finland and the USA ("N"?=?13) were asked to describe positive or successful situations or chains of events in which their…

  18. Mock Interview Strategy: An Action Research Study of Administrator and Teacher Candidates' Preparation for Interview Field Experience

    ERIC Educational Resources Information Center

    Harchar, Rayma

    2005-01-01

    Schools of graduate and undergraduate education can be of great help to each other. To be an effective interviewer or interviewee, a person must have experience. The perceived self-efficacy of interviewing skills may help in actual interviews. A mock interview strategy is proposed to help administrator and teacher candidates become proficient in…

  19. 77 FR 74183 - Farm Credit Administration Board Action To Approve a Plan of Voluntary Liquidation for, and To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ... the Charter of, the Farm Credit Finance Corporation of Puerto Rico AGENCY: Farm Credit Administration... voluntary liquidation of the Farm Credit Finance Corporation of Puerto Rico (FCFCPR) without the appointment... Credit Finance Corporation of Puerto Rico under FCA's regulation Sec. 627.2795--Voluntary Liquidation...

  20. Comparison of early reactions of the blood system in rats to immobilization, the action of hypoxia and the administration of erythopoietin

    NASA Technical Reports Server (NTRS)

    Gorizontov, P. D.; Fedotova, M. I.; Gudim, V. I.; Belousova, O. I.

    1980-01-01

    Three series of experiments were simultaneously carried on rats with the purpose of studying the action of different stimulants on the blood system; rats were subjected to immobilization, hypoxic hypoxia and erythropoietin administration. Changes in various cellular forms in the bone marrow, the thymus and the spleen were studied. A unitypical reaction, as in stress, was noted during the first hours; a reduction of the cell count in the lymphoid organs, a reduction of granulocytes and an increase of lymphoid cells in the bone marrow. The differences were chiefly quantitative. This was followed by stimulation of myelo and erythropoiesis determined by the specific features of the action applied. Nonspecific blood reaction was apparently due to activation of the adaptation mechanisms.

  1. Understanding the Role of Public Administration in Implementing Action on the Social Determinants of Health and Health Inequities

    PubMed Central

    Carey, Gemma; Friel, Sharon

    2015-01-01

    Many of the societal level factors that affect health – the ‘social determinants of health (SDH)’ – exist outside the health sector, across diverse portfolios of government, and other major institutions including non-governmental organisations (NGOs) and the private sector. This has created growing interest in how to create and implement public policies which will drive better and fairer health outcomes. While designing policies that can improve the SDH is critical, so too is ensuring they are appropriately administered and implemented. In this paper, we draw attention to an important area for future public health consideration – how policies are managed and implemented through complex administrative layers of ‘the state.’ Implementation gaps have long been a concern of public administration scholarship. To precipitate further work in this area, in this paper, we provide an overview of the scholarly field of public administration and highlight its role in helping to understand better the challenges and opportunities for implementing policies and programs to improve health equity. PMID:26673462

  2. A pharmacokinetic/clinical approach to postulate a local action of intra-articular xylazine administration in the horse: a preliminary study.

    PubMed

    Di Salvo, A; Della Rocca, G; Bazzica, C; Giontella, A; Cagnardi, P; Nannarone, S

    2014-10-01

    The study aims to evaluate whether the analgesic effect of intra-articular (IA) route of xylazine administered to horses following arthroscopic surgery is due to a local or a systemic action. Two connected studies were performed. In the first, 1 mg/kg b.w. of xylazine was injected IA, and blood samples were taken to assess drug systemic absorption. In addition, systemic effects of the drug (sedation, ataxia or reduction of respiratory and cardiac rate) were registered. Control horses injected with saline IA were included in the study to exclude the influence of anaesthesia in the occurrence of these manifestations. In the second study, 1 mg/kg b.w. of xylazine was administered intravenously (i.v.) in healthy horses. Blood samples were collected to determine the concentrations of xylazine, and the same signs of systemic effects of the drug were recorded. By correlating these parameters, a systemic 'no effect' concentration was defined. Pharmacokinetic data after IA administration resulted in some xylazine absorption (bioavailability equal to 58.12%) with values above the systemic 'no effect' concentration. The occurrence of some signs related to systemic effects in horses receiving IA xylazine was significant compared with horses receiving saline. In conclusion, a systemic action of the drug after IA administration cannot be excluded. PMID:24606045

  3. Tracer kinetics and actions of oral and intraperitoneal 1,25-dihydroxyvitamin D3 administration in rats

    SciTech Connect

    Vieth, R.; Kooh, S.W.; Balfe, J.W.; Rawlins, M.; Tinmouth, W.W. )

    1990-11-01

    Tracer kinetic parameters of ({sup 3}H)-1,25(OH)2D3 were calculated from data obtained following its acute oral (p.o.) or intraperitoneal (i.p.) administration. In normal rats studied after the tracer had distributed into the body, the slope and intercept of the log-serum ({sup 3}H)-1,25(OH)2D3 versus time relationship were not significantly influenced by the route of administration. Pretreatment with 1,25(OH)2D3 (0.2 micrograms/100 g/day) by the same route as the tracer resulted in the following changes: in p.o. rats the serum ({sup 3}H)-1,25(OH)2D3 intercept was much lower but the slope was not changed; in i.p. rats the intercept was not changed but the slope was increased. Both p.o. and i.p. treatment with 1,25(OH)2D3 lowered the weight gain and diet consumption, and increased serum calcium, kidney tissue calcium and urinary excretion of orally administered {sup 45}Ca. All the measures of bioactivity were greater in the i.p. dosed rats than in the p.o. dosed rats. We conclude that the p.o. 1,25(OH)2D3 was less potent because of diminished bioavailability due to self induction of its presystemic metabolism and inactivation.

  4. SAVEnergy Action Plan: National Oceanic and Atmospheric Administration, National Marine Fisheries Service, Northwest Fisheries Science Center, Seattle, Washington

    SciTech Connect

    Parker, S.A.; Wahlstrom, R.R.; Richman, E.E.; Sandusky, W.F. III; Dittmer, A.L.

    1995-05-01

    The Pacific Northwest Laboratory (PNL) conducted a SAVEnergy Audit of the National Oceanic and Atmospheric Administration`s (NOAA) National Marine Fisheries Service, Northwest Fisheries Science Center in Seattle, Washington. The objectives of this study were to evaluate the performance of all energy-consuming equipment in the facility, to estimate energy consumption and demand by end-use and to recommend energy conservation measures (ECMs) and water conservation measures (WCMs) to reduce costs . This section describes the facility and the systems encountered during the visit by the audit team. It also presents a summary of energy conservation measures. Section 2 shows energy consumption and costs for electricity, natural gas and water. A breakdown of energy consumed by end-use is also presented. Recommended energy conservation measures are presented in Section 3. Section 4 contains a discussion of operations and maintenance issues and other energy measures that can be implemented on a replace-on-failure basis rather than replacing immediately. Appendix A contains a three-year history of consumption, demand and cost for electric, natural gas and water utilities. Appendix B contains information on local weather data correlated to utility billing periods. A brief summary on Federal life-cycle costing is located in Appendix C along with the life-cycle cost analyses summaries for the energy and water conservation measures detailed in this report. Information on the rebate program sponsored by Seattle City Light, the electric utility, is located in Appendix D. Sample information for water-efficient equipment is located in Appendix E. Appendix F contains submittal forms to the Federal Energy Efficiency Fund for the energy conservation measures recommended in Section 3 of this report. A glossary of terms and abbreviations used in this report is located in Appendix G.

  5. [Exercise tolerance in angina patients 3 and 24 hours after administration of a new delayed-action preparation of metoprolol].

    PubMed

    Giusti, C; Verdecchia, P; Pentimone, F; Regoli, F; Cordoni, M; Bongini, A M

    1981-01-01

    To assess the duration of improved exercise tolerance by metoprolol given in a new sustained-release formulation, 40 in-patients affected by stable exercise-induced angina pectoris received single-blind placebo in day 1 and thereafter, in double-blind cross-over once daily administration, metoprolol RETARD 100 mg and 200 mg in days 3 and 5. Symptom-limited cycloergometric exercise tests were performed at 3 and 24 hours after placebo and after each of the two doses of metoprolol RETARD. Duration of exercise, maximal workload and total work performed did significantly increase at 3 and 24 hours after metoprolol RETARD 100 mg (P less than 0.01) and 200 mg (P less than 0.01), without any significant difference between the two doses. Peak systolic arterial pressure and heart rate were lowered by metoprolol RETARD 200 mg at 3 (P less than 0.01) and 24 (P less than 0.01) hours, whereas only the peak heart rate at 3 hours was lowered (P less than 0.05) by the 100 mg dose. It is concluded that in patients with stable exercise-induced angina pectoris, metoprolol RETARD 200 mg appears to be able to increase exercise tolerance and to reduce exercise-induced myocardial oxygen consumption throughout 24 hours period. This may justify a once daily dosing schedule of the 200 mg dose, aimed at improving patient compliance. PMID:7343379

  6. Tobacco regulatory science: research to inform regulatory action at the Food and Drug Administration's Center for Tobacco Products.

    PubMed

    Ashley, David L; Backinger, Cathy L; van Bemmel, Dana M; Neveleff, Deborah J

    2014-08-01

    The U.S. Food and Drug Administration (FDA) promotes the development of regulatory science to ensure that a strong evidence base informs all of its regulatory activities related to the manufacture, marketing, and distribution of tobacco products as well as public education about tobacco product constituents and effects. Toward that end, the FDA's Center for Tobacco Products (CTP) provides funding for research studies with scientific aims that fall within its defined regulatory authority. However, given their traditional biomedical focus on basic and applied research, some researchers may not understand the principles of regulatory science or the types of studies CTP funds. The purpose of this paper is (1) to clarify the definition of regulatory science as a distinct scientific discipline, (2) to explore the role of tobacco regulatory science in order to help researchers understand the parameters and types of research that can be funded by CTP, and (3) to describe the types of research efforts that will inform the FDA's public health framework for tobacco product regulation. PMID:24638850

  7. Proposed actions for the US Food and Drug Administration to implement to minimize adverse effects associated with energy drink consumption.

    PubMed

    Thorlton, Janet; Colby, David A; Devine, Paige

    2014-07-01

    Energy drink sales are expected to reach $52 billion by 2016. These products, often sold as dietary supplements, typically contain stimulants. The Dietary Supplement Protection Act claims an exemplary public health safety record. However, in 2011 the number of emergency department visits related to consumption of energy drinks exceeded 20,000. Nearly half of these visits involved adverse effects occurring from product misuse. Political, social, economic, practical, and legal factors shape the landscape surrounding this issue. In this policy analysis, we examine 3 options: capping energy drink caffeine levels, creating a public education campaign, and increasing regulatory scrutiny regarding the manufacture and labeling of energy drinks. Increased regulatory scrutiny may be in order, especially in light of wrongful death lawsuits related to caffeine toxicity resulting from energy drink consumption. PMID:24832439

  8. We Need Action on Social Determinants of Health - but Do We Want It, too? Comment on "Understanding the Role of Public Administration in Implementing Action on the Social Determinants of Health and Health Inequities".

    PubMed

    de Leeuw, Evelyne

    2016-01-01

    Recently a number of calls have been made to mobilise the arsenal of political science insights to investigate - and point to improvements in - the social determinants of health (SDH), and health equity. Recently, in this journal, such a rallying appeal was made for the field of public administration. This commentary argues that, although scholarly potential should justifiably be redirected to resolve these critical issues for humanity, a key ingredient in taking action may have been neglected. This factor is 'community.' Community health has been a standard element of the public health and health promotion, even political, repertoire for decades now. But this commentary claims that communities are insufficiently charged, equipped or appreciated to play the role that scholarship attributes (or occasionally avoids to identify) to them. Community is too important to not fully engage and understand. Rhetorical tools and inquiries can support their quintessential role. PMID:27285516

  9. Naturally occurring chemical carcinogens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Natural products are chemicals found in nature which have unique pharmacological effects. Humans are exposed to many of these bioactive naturally occurring chemicals via the air breathed, the water drunk and the food eaten. Exposure also occurs in clinical settings. Naturally occurring chemicals ...

  10. Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original mechanism of action.

    PubMed

    Carillon, Julie; Rouanet, Jean-Max; Cristol, Jean-Paul; Brion, Richard

    2013-11-01

    Oxidative stress, involved in many diseases, is defined as an impaired balance between reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes such as superoxide dismutase (SOD) play a key role in diminishing oxidative stress. Thus, the removal of ROS by exogenous SODs could be an effective preventive strategy against various diseases. The poor bioavailability of exogenous SODs has been criticized. However, improvements in SOD formulation may overcome this limitation and boost interest in its therapeutic properties. Here, we provide a review of animal and human studies about SODs supplementation in order to evaluate their therapeutic value. Protective effects have been observed against irradiation, carcinogenesis, apoptosis and neurodegeneration. SODs administration has also been reported to alleviate inflammatory, infectious, respiratory, metabolic and cardiovascular diseases and genitourinary and fertility disorders, raising the question of its mechanism of action in these diverse situations. Some authors have shown an increase in endogenous antioxidant enzymes after exogenous SODs administration. The induction of endogenous antioxidant defence and, consequently, a decrease in oxidative stress, could explain all the effects observed. Further investigations need to be carried out to test the hypothesis that SODs supplementation acts by inducing an endogenous antioxidant defence. PMID:23793992

  11. Mechanisms of corticosteroid action on lymphocyte subpopulations. III. Differential effects of dexamethasone administration on subpopulations of effector cells mediating cellular cytotoxicity in man

    PubMed Central

    Parrillo, J. E.; Fauci, A. S.

    1978-01-01

    The present study investigated the effect of dexamethasone (DEX) administration on different populations of mononuclear cells and neutrophils mediating antibody-dependent cellular cytotoxicity (ADCC) against different target cells. Mononuclear cells (lymphocytes and monocytes) and neutrophils were obtained from twenty-seven normal volunteers at 0, 4, 24 and 48 hr after oral administration of 21 mg of DEX. ADCC was determined utilizing the following targets: human red blood cells (HRBC), Chang liver cells (Ch) and human heart cells (HHC). The predominant mononuclear effector in HRBC killing was shown to be a monocyte and in Ch and HHC killing, a K cell. As previously shown, DEX produced a profound monocytopenia and lymphocytopenia at 4 hr with a return of lymphocyte counts to normal and monocyte counts to supra-normal at 24 hr. At the point of maximal monocytopenia, monocyte-mediated HRBC killing decreased from a geometric mean of 14 to 4 lytic units per 108 effector cells (P<0·05) and rebounded at 24 hr to a mean of 39 lytic units (P<0·02) with the rebound monocytosis. At the point of absolute lymphopenia (4 hr), there was a relative enrichment in the proportion of lymphocytes bearing an Fc receptor (K cells, P<0·01). Concomitant with this was an increase in ADCC against Ch and HHC from geometric means of 1121 to 7172 lytic units and 939 to 7354 lytic units (P<0·001) respectively. Thus, a major action of DEX administration on mononuclear ADCC was to differentially enrich or deplete different effector cells to and from the circulation, causing changes in cytotoxicity. Since the cytotoxicity paralleled the proportion of effector cells, the cells remaining in the circulation following DEX administration retained normal antibody-dependent cytotoxic capabilities. Neutrophil-mediated ADCC against HRBC significantly increased at 4 hr from a geometric mean of 3785 to 20142 lytic units (P<0·02) concomitant with the blood neutrophilia and remained elevated for 72 hr

  12. Co-Occurring Disorders

    MedlinePlus

    ... Care of You Top Ten Freshman Year Issues Alcohol, Substance Abuse and Depression Winter Break Survival Tips for College Students Implementing ... supporters and consumers in the mental health field. Alcohol and Drug Abuse, Addiction and Co-occurring Disorders: Co-occurring ... In Crisis? Call ...

  13. 77 FR 12865 - Enforcement Actions Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... Government Printing Office's Web page at http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR... SECURITY Transportation Security Administration Enforcement Actions Summary AGENCY: Transportation Security Administration, DHS. ACTION: Notice of availability. SUMMARY: The Transportation Security Administration (TSA)...

  14. 78 FR 11216 - Enforcement Actions Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ... Government Printing Office's web page at http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR... SECURITY Transportation Security Administration Enforcement Actions Summary AGENCY: Transportation Security Administration, DHS. ACTION: Notice of availability. SUMMARY: The Transportation Security Administration (TSA)...

  15. Pharmacokinetics and pharmacodynamic action of budesonide after buccal administration in healthy subjects and patients with oral chronic graft-versus-host disease.

    PubMed

    Dilger, Karin; Halter, Jörg; Bertz, Hartmut; Lopez-Lazaro, Luis; Gratwohl, Alois; Finke, Jürgen

    2009-03-01

    Buccal administration of budesonide (mouthwash) may be effective as a topical add-on therapy in patients with oral chronic graft-versus-host disease (cGVHD). Safety of approved oral budesonide is based on high intestinal and hepatic extraction by cytochrome P450 3A (CYP3A) enzymes. The purpose of this study was to evaluate the presystemic extraction and pharmacodynamic action of buccal budesonide. Oral budesonide (3 mg) was taken as reference to which various single and multiple dose regimens of buccal budesonide were compared. Budesonide and the 2 main CYP3A-dependent metabolites (6beta-hydroxybudesonide, 16alpha-hydroxyprednisolone) were analyzed in blood and urine along with the drug's effect on endogenous cortisol in 12 healthy subjects and 7 patients with oral cGVHD. We assessed CYP3A-dependent metabolites in both healthy subjects and patients after buccal budesonide. Whereas systemic exposure to budesonide was markedly lower in healthy subjects after the mouthwash compared to oral dosing (mean relative bioavailability 18%-36%), the systemic concentrations thereafter in patients were as high as those after the identical dose of oral budesonide. Reduced buccal CYP3A activity (lower inactivation of budesonide) in patients contributed to this remarkable difference. Endogenous cortisol was suppressed in some patients during 1 week of continuous treatment with buccal budesonide (3 x 3 mg per day). We are the first to report the biotransformation of budesonide via CYP3A enzymes after buccal drug administration. Only 2% of a buccal dose of budesonide achieves systemic circulation in healthy individuals; that fraction is 10% in patients with oral cGVHD, probably because of alterations in drug uptake and metabolization. PMID:19203724

  16. The in vitro effective antiviral action of povidone-iodine (PVP-I) may also have therapeutic potential by its intravenous administration diluted with Ringer's solution.

    PubMed

    Sabracos, Labros; Romanou, Solomi; Dontas, Ismene; Coulocheri, Stavroula; Ploumidou, Kathrin; Perrea, Despina

    2007-01-01

    The use of povidone-iodine (PVP-I) is well known in clinical medical practice. In vitro studies of cell cultures infected by HIV and H5N1 virus have shown that PVP-I has an antiviral action, while the cell hosts were not affected and survived. It is therefore worth investigating whether PVP-I, diluted with Ringer's solution, may have a therapeutic effect by parenteral administration. Specifically, the question is whether small concentrations of intravenous PVP-I could be well tolerated by the human organism, and in addition, if it would be possible to detect a beneficial activity. Its intravenous use may have a potential value against infections (by microbes, viruses, fungi and parasites), as well as an anti-inflammatory activity, especially in cases where antibiotics are ineffective. It could be used as a blood disinfectant, for treating burns, for the prevention of cancer, for the therapy of H5N1 influenza after its mutation, and other potential applications. PMID:17113717

  17. Co-administration of memantine with epinephrine produces a marked peripheral action in intensifying and prolonging analgesia in response to local skin pinprick in rats.

    PubMed

    Chen, Yu-Wen; Tzeng, Jann-Inn; Pan, He-Jia; Hung, Ching-Hsia; Chen, Yu-Chung; Wang, Jhi-Joung

    2014-06-27

    The purpose of this study was to examine the effect of epinephrine as adjuvant for memantine or lidocaine as an infiltrative anesthetic. Using a rat model of cutaneous trunci muscle reflex (CTMR), we evaluated the effects of adding epinephrine to memantine or lidocaine on infiltrative cutaneous analgesia. Lidocaine, a known local anesthetic, was used as control. We found that epinephrine, memantine, and lidocaine produced a dose-dependent local anesthetic effect as infiltrative cutaneous analgesia. On a 50% effective dose (ED50) basis, the relative potencies were epinephrine [0.012 (0.006-0.020)μmol]>memantine [4.010 (3.311-4.988)μmol]>lidocaine [6.177 (5.333-7.218)μmol] (P<0.05 for each comparison). Mixtures of epinephrine (2.7nmol or 13.7nmol) with drugs (memantine or lidocaine) at ED50 or ED95, respectively, enhanced the potency and prolonged the duration of action on infiltrative cutaneous analgesia. Intraperitoneal injection of co-administration of drugs (memantine or lidocaine) at ED95 with epinephrine (13.7nmol) produced no cutaneous analgesia (data not shown). Epinephrine, memantine, and lidocaine were shown to have local anesthetic effects as infiltrative cutaneous analgesia. Epinephrine increased the duration and potency of memantine and lidocaine as an infiltrative anesthetic. PMID:24861513

  18. "Naturally occurring asbestos

    NASA Astrophysics Data System (ADS)

    Cagnard, F.; Lahondère, D.; Blein, O.; Lahfid, A.; Wille, G.

    2012-04-01

    The term asbestos refers to six silicate minerals from amphibole and serpentine groups. By definition, it consists in bundles of thin and flexible long fibers, with high-tensile strength, and chemical and heat resistance. In contrast to asbestos found within commercial products and mining, the specific term ''naturally occurring asbestos'' (NOA) refers to asbestiform minerals occurring within rocks or soils that can be released by human activities or weathering processes. The fact that the exposure to asbestos is related to lung pathologies is now widely demonstrated (e.g. asbestosis, mesothelioma and lung cancer). However, if health risks associated with exposure to NOA exist, they are not yet well documented. The crystallization of natural asbestos occurs in specific Mg-rich lithologies associated with peculiar structural and metamorphic conditions. By recognizing and combining such specific geologic criteria, the presence or the absence of asbestos in bedrock terrains can be reasonably predicted and maps of NOA hazard can be drawn. We present here new results of geological mapping and petrological study concerning the evaluation of the NOA hazard in the Alps and Corsica, in France. The three folds approach consists in (1) a determination of lithologies with potential NOA from a bibliographic compilation and extraction of target zones from a geological geodatabase (2) a geological mapping of the target zones followed by a petrological characterization of sampled asbestiform minerals in the laboratory (optical microscopy, TEM, SEM, and Raman spectroscopy technics), and (3) the drawing of the final map of NOA hazard, at regional-scale. Occurrence criteria can be retained as follows: 1. NOA are abundant in the internal zones of the Alps and Corsica, especially within ophiolitic complexes. Natural asbestos are mostly concentrated within ultramafic rocks but can also occur within basic lithologies such as Mg-metagabbros, metabasalts and meta-pillow-lavas, 2. Asbestos

  19. Cocaine action on peripheral, non-monoamine neural substrates as a trigger of electroencephalographic desynchronization and electromyographic activation following i.v. administration in freely moving rats.

    PubMed

    Smirnov, M S; Kiyatkin, E A

    2010-01-20

    Many important physiological, behavioral and subjective effects of i.v. cocaine (COC) are exceptionally rapid and transient, suggesting a possible involvement of peripheral neural substrates in their triggering. In the present study, we used high-speed electroencephalographic (EEG) and electromyographic (EMG) recordings (4-s resolution) in freely moving rats to characterize the central electrophysiological effects of i.v. COC at low doses within a self-administration range (0.25-1.0 mg/kg). We found that COC induces rapid, strong, and prolonged desynchronization of cortical EEG (decrease in alpha and increase in beta and gamma activity) and activation of the neck EMG that begin within 2-6 s following the start of a 10-s injection; immediate components of both effects were dose-independent. The rapid effects of COC were mimicked by i.v. COC methiodide (COC-MET), a derivative that cannot cross the blood-brain barrier. At equimolar doses (0.33-1.33 mg/kg), COC-MET had equally fast and strong effects on EEG and EMG total powers, decreasing alpha and increasing beta and gamma activities. Rapid EEG desynchronization and EMG activation was also induced by i.v. procaine, a structurally similar, short-acting local anesthetic with virtually no effects on monoamine uptake; at equipotential doses (1.25-5.0 mg/kg), these effects were weaker and shorter in duration than those of COC. Surprisingly, i.v. saline injection delivered during slow-wave sleep (but not during quiet wakefulness) also induced a transient EEG desynchronization but without changes in EMG and motor activity; these effects were significantly weaker and much shorter than those induced by all tested drugs. These data suggest that in awake animals, i.v. COC induces rapid cortical activation and a subsequent motor response via its action on peripheral non-monoamine neural elements, involving neural transmission via visceral sensory pathways. By providing a rapid neural signal and triggering neural activation, such

  20. 78 FR 9771 - Federal Highway Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... Federal Highway Administration Notice of Final Federal Agency Action on Proposed Transportation Project in Illinois and Indiana AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of limitation on..., Federal Highway Administration, 3250 Executive Park Drive, Springfield, Illinois 62703, Phone: (217)...

  1. Technology assessment and citizen action

    NASA Technical Reports Server (NTRS)

    Mottur, E. R.

    1972-01-01

    The importance of citizen participation in the assessment process is discussed, and a system for citizen assessment action is proposed. A national assessment system is outlined. Citizen participation is considered essential in the assessment process, and impediments to effective action taken by citizens are discussed. These impediments are finance, organization and motivation, and information. The establishment of citizens' assessment associations is proposed, whose functioning would be fostered and regulated by the Citizens' Assessment Administration. The organization, functions, and financing of these associations are described. The implications of citizen action are indicated as the extensive use of class action suits, the broad interpretation of associated costs of litigation, and the use of present scientific research as evidence to assert that it is reasonable to conclude that certain consequences are probable to occur in the future.

  2. Naturally occurring cardiac glycosides.

    PubMed

    Radford, D J; Gillies, A D; Hinds, J A; Duffy, P

    1986-05-12

    Cardiac glycoside poisoning from the ingestion of plants, particularly of oleanders, occurs with reasonable frequency in tropical and subtropical areas. We have assessed a variety of plant specimens for their cardiac glycoside content by means of radioimmunoassays with antibodies that differ in their specificity for cardiac glycosides. Significant amounts of immunoreactive cardiac glycoside were found to be present in the ornamental shrubs: yellow oleander (Thevetia peruviana); oleander (Nerium oleander); wintersweet (Carissa spectabilis); bushman's poison (Carissa acokanthera); sea-mango (Cerbera manghas); and frangipani (Plumeria rubra); and in the milkweeds: redheaded cotton-bush (Asclepias curassavica); balloon cotton (Asclepias fruiticosa); king's crown (Calotropis procera); and rubber vine (Cryptostegia grandifolia). The venom gland of the cane toad (Bufo marinus) also contained large quantities of cardiac glycosides. The competitive immunoassay method permits the rapid screening of specimens that are suspected to contain cardiac glycosides. Awareness of the existence of these plant and animal toxins and their dangers allows them to be avoided and poisoning prevented. The method is also useful for the confirmation of the presence of cardiac glycosides in serum in cases of poisoning. PMID:3086679

  3. 29 CFR 102.48 - Action of the Board upon expiration of time to file exceptions to the administrative law judge's...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 2 2013-07-01 2013-07-01 false Action of the Board upon expiration of time to file... Unfair Labor Practices 1 Procedure Before the Board § 102.48 Action of the Board upon expiration of time... of any request for an extension of time shall be served promptly on the other parties. (3) The...

  4. 29 CFR 102.48 - Action of the Board upon expiration of time to file exceptions to the administrative law judge's...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 2 2011-07-01 2011-07-01 false Action of the Board upon expiration of time to file... Unfair Labor Practices 1 Procedure Before the Board § 102.48 Action of the Board upon expiration of time... of any request for an extension of time shall be served promptly on the other parties. (3) The...

  5. 29 CFR 102.48 - Action of the Board upon expiration of time to file exceptions to the administrative law judge's...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 2 2012-07-01 2012-07-01 false Action of the Board upon expiration of time to file... Unfair Labor Practices 1 Procedure Before the Board § 102.48 Action of the Board upon expiration of time... of any request for an extension of time shall be served promptly on the other parties. (3) The...

  6. 29 CFR 102.48 - Action of the Board upon expiration of time to file exceptions to the administrative law judge's...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 2 2014-07-01 2014-07-01 false Action of the Board upon expiration of time to file... Unfair Labor Practices 1 Procedure Before the Board § 102.48 Action of the Board upon expiration of time... of any request for an extension of time shall be served promptly on the other parties. (3) The...

  7. 78 FR 18420 - Special Permit Applications Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Pipeline and Hazardous Materials Safety Administration Special Permit Applications Actions AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice of actions on special... processing of, special permits from the Department of Transportation's Hazardous Material Regulations (49...

  8. 22 CFR 223.11 - Appropriate action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Appropriate action. 223.11 Section 223.11...-EMPLOYMENT RESTRICTIONS § 223.11 Appropriate action. The Administrator may take appropriate action in the... action....

  9. A Reference-Intensive Embedded Librarian Program: Kresge Business Administration Library's Program to Support Action-Based Learning at the Ross School of Business

    ERIC Educational Resources Information Center

    Berdish, Laura; Seeman, Corey

    2010-01-01

    While a great deal of literature on embedded librarians in academic libraries is focused on the role of instructor, there are many other services that could be provided by librarians working closely with students. The Kresge Business Administration Library (Stephen M. Ross School of Business at the University of Michigan) has created a unique…

  10. An Action Research Study of Mexican Teachers' and Administrators' Experiences in Developing and Implementing a Service Learning Program

    ERIC Educational Resources Information Center

    Acuna, Kym

    2013-01-01

    The purpose of this study was to examine the High Tec Middle School teachers' and administrators' knowledge of the service learning model upon which the school's service learning program has been based, their views regarding their role in student character formation through service learning, and the teachers' feelings of…

  11. 20 CFR 1002.167 - What actions may a plan administrator take if the employee does not elect or pay for continuing...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Omnibus Budget Reconciliation Act of 1985, 26 U.S.C. 4980B (COBRA), it may be reasonable for a health plan administrator to adopt COBRA-compliant rules regarding election of continuing coverage, as long as those rules... cancellation of coverage if timely payment is not made. Where health plans are covered under COBRA, it may...

  12. 20 CFR 1002.167 - What actions may a plan administrator take if the employee does not elect or pay for continuing...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Omnibus Budget Reconciliation Act of 1985, 26 U.S.C. 4980B (COBRA), it may be reasonable for a health plan administrator to adopt COBRA-compliant rules regarding election of continuing coverage, as long as those rules... cancellation of coverage if timely payment is not made. Where health plans are covered under COBRA, it may...

  13. 20 CFR 1002.167 - What actions may a plan administrator take if the employee does not elect or pay for continuing...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Omnibus Budget Reconciliation Act of 1985, 26 U.S.C. 4980B (COBRA), it may be reasonable for a health plan administrator to adopt COBRA-compliant rules regarding election of continuing coverage, as long as those rules... cancellation of coverage if timely payment is not made. Where health plans are covered under COBRA, it may...

  14. 20 CFR 1002.167 - What actions may a plan administrator take if the employee does not elect or pay for continuing...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Omnibus Budget Reconciliation Act of 1985, 26 U.S.C. 4980B (COBRA), it may be reasonable for a health plan administrator to adopt COBRA-compliant rules regarding election of continuing coverage, as long as those rules... cancellation of coverage if timely payment is not made. Where health plans are covered under COBRA, it may...

  15. Naturally Occuring Fish Poisons from Plants

    NASA Astrophysics Data System (ADS)

    Cannon, Jonathan G.; Burton, Robert A.; Wood, Steven G.; Owen, Noel L.

    2004-10-01

    Since prehistoric times, cultures throughout the world have used piscicidal (fish poisoning) plants for fishing. In recent times, scientists have identified many of the plant compounds responsible for killing the fish and have found that these compounds possess other important biological properties, such as insecticidal and anti-cancer activities. This article reviews some of the chemical research that has been performed on naturally occurring fish poisons, including plant sources, methods of use, toxicity, and mechanisms of action of piscicides.

  16. The Department of Veterans Health Administration Office of Nursing Service, "transforming nursing in a national healthcare system: an example of transformation in action".

    PubMed

    Wertenberger, Sydney; Chapman, Kathleen M; Wright-Brown, Salena

    2011-01-01

    The Department of Veterans Health Administration Office of Nursing Service has embarked on a multiyear transformational process, an example of which is the development of an organization-wide nursing handbook. The development of this handbook offered the opportunity to improve collaboration, redefine expectations and behavior, as well as prepare for the future of Nursing within the Veterans Health Administration. The lessons learned from this process have revolved around the themes of leadership skills for managing high-level change often in a virtual environment; constant collaboration; that the practice of nursing will continue to evolve on the basis of new evidence, technology, customer expectations, and resources; and that the process to accomplish this goal is powerful. PMID:21654487

  17. 75 FR 57820 - National Credit Union Administration Restoration Plan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... ADMINISTRATION National Credit Union Administration Restoration Plan AGENCY: National Credit Union Administration (NCUA). ACTION: Approval of National Credit Union Administration restoration plan. On September 16, 2010, the National Credit Union Administration (NCUA) implemented a Restoration Plan for the National...

  18. 76 FR 5212 - Employment and Training Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... Employment and Training Administration Comment Request for Information Collection for Internal Fraud and...: Employment and Training Administration (ETA), Department of Labor. ACTION: Notice. SUMMARY: The Department of.... Currently, the Employment and Training Administration is soliciting comments concerning the Office...

  19. 76 FR 78966 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... Federal Aviation Administration Approval of Noise Compatibility Program for Kona International Airport at Keahole, Keahole, North Kona, HI AGENCY: Federal Aviation Administration, DOT. ACTION: Notice. SUMMARY: The Federal Aviation Administration (FAA) announces its findings on the noise compatibility...

  20. Inhibition of trigeminal neurones after intravenous administration of naratriptan through an action at 5-hydroxy-tryptamine (5-HT1B/1D) receptors

    PubMed Central

    Goadsby, Peter J; Knight, Yolande

    1997-01-01

    The observation that 5-hydroxytryptamine (5-HT) is effective in treating acute attacks of migraine when administered intravenously resulted in a research effort that led to the discovery of the 5-HT1B/1D receptor agonist sumatriptan. Clinical experience has shown sumatriptan to be an effective treatment with some limitations, such as relatively poor bioavailability, which naratriptan was developed to address. Increasing bioavailability has been achieved with greater lipophilicity and thus the potential for greater activity in the central nervous system. In this study the increased access to central sites has been exploited in an attempt to characterize the pharmacology of those central receptors with the newer tools available. Trigeminovascular activation was examined in the model of superior sagittal sinus stimulation. Cats were anaesthetized with α-chloralose (60 mg kg−1, intraperitoneal), paralyzed (gallamine 6 mg kg−1, intravenously) and ventilated. The superior sagittal sinus was accessed and isolated for electrical stimulation (250 μs pulses, 0.3 Hz, 100 V) by a mid-line circular craniotomy. The region of the dorsal surface of C2 spinal cord was exposed by a laminectomy and an electrode placed for recording evoked activity from sinus stimulation. Stimulation of the superior sagittal sinus resulted in activation of cells in the dorsal horn of C2. Cells fired with a probability of 0.69±0.1 at a latency of 9.2±0.2 ms. Intravenous (i.v.) administration of naratriptan at clinically relevant doses (30 and 100 μg kg−1), inhibited neuronal activity in trigeminal neurones of the C2 dorsal horn, reducing probability of firing without affecting latency. The effect of naratriptan could be reversed by administration of the selective 5-HT1B/1D receptor antagonist GR127935 (100 μg kg−1, i.v.). These data establish that naratriptan acts on central trigeminal neurones since sagittal sinus stimulation activates axons within the tentorial

  1. Similar effects of intranasal oxytocin administration and acute alcohol consumption on socio-cognitions, emotions and behaviour: Implications for the mechanisms of action.

    PubMed

    Mitchell, Ian J; Gillespie, Steven M; Abu-Akel, Ahmad

    2015-08-01

    Oxytocin (OT) plays a critical role in the formation of long lasting social attachments across a range of mammalian species. Raising intracerebral OT levels by intranasal administration of the neuropeptide (inOT) can also have pronounced effects on human sociocognitive functioning. inOT has been associated with increasing altruism, generosity, empathy and trust while decreasing fear, anxiety and stress reactions via neural mechanisms which are yet to be fully elucidated. The observation of the prosocial effects of OT has led to speculation about the role the peptide might play in some psychiatric conditions and debate as to its potential therapeutic uses. Here we note the great similarity in the sociocognitive effects that can be induced by inOT and the effects of acute consumption of modest does of alcohol. We further reflect on how both compounds may act on limbic and prefrontal cortical structures to increase GABAergic transmission, thereby facilitating the release of prepotent responses, that is, more automatic responses which are associated with earlier developmental stages. PMID:25956250

  2. Naturally Occurring Radioactive Materials (NORM)

    SciTech Connect

    Gray, P.

    1997-02-01

    This paper discusses the broad problems presented by Naturally Occuring Radioactive Materials (NORM). Technologically Enhanced naturally occuring radioactive material includes any radionuclides whose physical, chemical, radiological properties or radionuclide concentration have been altered from their natural state. With regard to NORM in particular, radioactive contamination is radioactive material in an undesired location. This is a concern in a range of industries: petroleum; uranium mining; phosphorus and phosphates; fertilizers; fossil fuels; forestry products; water treatment; metal mining and processing; geothermal energy. The author discusses in more detail the problem in the petroleum industry, including the isotopes of concern, the hazards they present, the contamination which they cause, ways to dispose of contaminated materials, and regulatory issues. He points out there are three key programs to reduce legal exposure and problems due to these contaminants: waste minimization; NORM assesment (surveys); NORM compliance (training).

  3. 25 CFR 163.33 - Administrative appeals.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.33 Administrative appeals. Any challenge to action under 25 CFR part 163... provisions of 25 CFR part 2, Appeals from administrative actions, except that an appeal of any action...

  4. 25 CFR 163.33 - Administrative appeals.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.33 Administrative appeals. Any challenge to action under 25 CFR part 163... provisions of 25 CFR part 2, Appeals from administrative actions, except that an appeal of any action...

  5. 25 CFR 163.33 - Administrative appeals.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.33 Administrative appeals. Any challenge to action under 25 CFR part 163... provisions of 25 CFR part 2, Appeals from administrative actions, except that an appeal of any action...

  6. 25 CFR 163.33 - Administrative appeals.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.33 Administrative appeals. Any challenge to action under 25 CFR part 163... provisions of 25 CFR part 2, Appeals from administrative actions, except that an appeal of any action...

  7. 25 CFR 163.33 - Administrative appeals.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER GENERAL FORESTRY REGULATIONS Forest Management and Operations § 163.33 Administrative appeals. Any challenge to action under 25 CFR part 163... provisions of 25 CFR part 2, Appeals from administrative actions, except that an appeal of any action...

  8. 26 CFR 301.7430-4 - Reasonable administrative costs.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Judicial Proceedings Civil Actions by the United... witnesses; (iii) Reasonable costs of any study, analysis, engineering report, test or project that...

  9. 26 CFR 301.7430-4 - Reasonable administrative costs.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Judicial Proceedings Civil Actions by the United... witnesses; (iii) Reasonable costs of any study, analysis, engineering report, test or project that...

  10. 26 CFR 301.7430-4 - Reasonable administrative costs.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...) PROCEDURE AND ADMINISTRATION PROCEDURE AND ADMINISTRATION Judicial Proceedings Civil Actions by the United... witnesses; (iii) Reasonable costs of any study, analysis, engineering report, test or project that...

  11. Detecting change as it occurs

    NASA Technical Reports Server (NTRS)

    Radok, Uwe; Brown, Timothy J.

    1992-01-01

    Traditionally climate changes have been detected from long series of observations and long after they have happened. Our 'inverse sequential' procedure, for detecting change as soon as it occurs, describes the existing or most recent data by their frequency distribution. Its parameter(s) are estimated both from the existing set of observations and from the same set augmented by 1,2,....j new observations. Individual-value probability products ('likelihoods') are used to form ratios which yield two probabilities for erroneously accepting the existing parameter(s) as valid for the augmented data set, and vice versa. A genuine parameter change is signaled when these probabilities (or a more stable compound probability) show a progressive decrease. New parameter values can then be estimated from the new observations alone using standard statistical techniques. The inverse sequential procedure will be illustrated for global annual mean temperatures (assumed normally distributed), and for annual numbers of North Atlantic hurricanes (assumed to represent Poisson distributions). The procedure was developed, but not yet tested, for linear or exponential trends, and for chi-squared means or degrees of freedom, a special measure of autocorrelation.

  12. Administrative Synergy

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  13. 78 FR 41183 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... Federal Aviation Administration Meeting: RTCA Program Management Committee AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION: Notice of RTCA Program Management.... Paige Williams, Management Analyst, NextGen, Business Operations Group, Federal Aviation...

  14. 77 FR 64837 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Federal Aviation Administration Fourth Meeting: RTCA Special Committee 227, Standards of Navigation Performance AGENCY: Federal Aviation Administration (FAA), U.S. Department of Transportation (DOT). ACTION... 15, 2012. Kathy Hitt, Management Analyst, Business Operations Group, Federal Aviation...

  15. 78 FR 25337 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Agency Information Collection Activities: Requests for Comments; Clearance... Administration (FAA), DOT. ACTION: Notice and request for comments. SUMMARY: In accordance with the...

  16. 75 FR 1029 - International Trade Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-08

    ... International Trade Administration AGENCY: Department of Commerce. ACTION: Notice. Mission Statement Medical..., International Trade Administration, U.S. and Foreign Commercial Service is organizing a Medical Trade Mission to... from international accreditation organizations such as the Joint Commission International...

  17. 22 CFR 223.11 - Appropriate action.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Appropriate action. 223.11 Section 223.11 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADMINISTRATIVE ENFORCEMENT PROCEDURES OF POST-EMPLOYMENT RESTRICTIONS § 223.11 Appropriate action. The Administrator may take appropriate action in...

  18. 46 CFR 327.8 - Court action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Court action. 327.8 Section 327.8 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION A-NATIONAL SHIPPING AUTHORITY SEAMEN'S CLAIMS; ADMINISTRATIVE ACTION AND LITIGATION § 327.8 Court action. No seamen, having a claim specified in subsections (2) and (3)...

  19. Three Generations of Educational Administration.

    ERIC Educational Resources Information Center

    Sharpe, F. G.

    This paper compares two Australian educational administration texts published in 1963 to reflect critically on the radical changes that have occurred in educational administration in Australia since then. The books are "Headmasters for Better Schools," by Bassett, Crane, and Walker; and "Training the Administrator," by Cunningham and Radford. The…

  20. 5 CFR 532.413 - Simultaneous action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Simultaneous action. 532.413 Section 532.413 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Pay Administration § 532.413 Simultaneous action. (a) If an employee becomes entitled to more...

  1. 5 CFR 532.413 - Simultaneous action.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Simultaneous action. 532.413 Section 532.413 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Pay Administration § 532.413 Simultaneous action. (a) If an employee becomes entitled to more...

  2. 5 CFR 532.413 - Simultaneous action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Simultaneous action. 532.413 Section 532.413 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Pay Administration § 532.413 Simultaneous action. (a) If an employee becomes entitled to more...

  3. 5 CFR 532.413 - Simultaneous action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Simultaneous action. 532.413 Section 532.413 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Pay Administration § 532.413 Simultaneous action. (a) If an employee becomes entitled to more...

  4. 5 CFR 532.413 - Simultaneous action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Simultaneous action. 532.413 Section 532.413 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PREVAILING RATE SYSTEMS Pay Administration § 532.413 Simultaneous action. (a) If an employee becomes entitled to more...

  5. 76 FR 9357 - Enforcement Actions Summary

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-17

    ....gpoaccess.gov/fr/index.html ; or (2) Visiting TSA's Security Regulations web page at http://www.tsa.gov and... SECURITY Transportation Security Administration Enforcement Actions Summary AGENCY: Transportation Security Administration, DHS. ACTION: Notice of Availability. SUMMARY: The Transportation Security Administration (TSA)...

  6. A Three Step Plan for Implementing an Affirmative Action Program

    ERIC Educational Resources Information Center

    Hilaael, Timothy M.

    1976-01-01

    (1) Centralize organizational responsibility for affirmative action. (2) Conduct an organizational audit related to the Equal Employment Opportunity Act. (3) Implement affirmative action as an administrative responsibility. (Author)

  7. 42 CFR 405.1875 - Administrator review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Administrator review. 405.1875 Section 405.1875... Appeals § 405.1875 Administrator review. (a) Basic rule: Time limit for rendering Administrator decisions, Board decisions, and action subject to immediate review. The Administrator, at his or her...

  8. 42 CFR 405.1875 - Administrator review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Administrator review. 405.1875 Section 405.1875... Appeals § 405.1875 Administrator review. (a) Basic rule: Time limit for rendering Administrator decisions, Board decisions, and action subject to immediate review. The Administrator, at his or her...

  9. 42 CFR 405.1875 - Administrator review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Administrator review. 405.1875 Section 405.1875... Appeals § 405.1875 Administrator review. (a) Basic rule: Time limit for rendering Administrator decisions, Board decisions, and action subject to immediate review. The Administrator, at his or her...

  10. 42 CFR 405.1875 - Administrator review.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Administrator review. 405.1875 Section 405.1875... Appeals § 405.1875 Administrator review. (a) Basic rule: Time limit for rendering Administrator decisions, Board decisions, and action subject to immediate review. The Administrator, at his or her...

  11. 42 CFR 405.1875 - Administrator review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Administrator review. 405.1875 Section 405.1875... Appeals § 405.1875 Administrator review. (a) Basic rule: Time limit for rendering Administrator decisions, Board decisions, and action subject to immediate review. The Administrator, at his or her...

  12. 22 CFR 217.6 - Remedial action, voluntary action, and self-evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Remedial action, voluntary action, and self... Provisions § 217.6 Remedial action, voluntary action, and self-evaluation. (a) Remedial action. (1) If the... another recipient exercises control over the recipient that has discriminated, the Administrator,...

  13. 22 CFR 217.6 - Remedial action, voluntary action, and self-evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Remedial action, voluntary action, and self... Provisions § 217.6 Remedial action, voluntary action, and self-evaluation. (a) Remedial action. (1) If the... another recipient exercises control over the recipient that has discriminated, the Administrator,...

  14. 22 CFR 217.6 - Remedial action, voluntary action, and self-evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Remedial action, voluntary action, and self... Provisions § 217.6 Remedial action, voluntary action, and self-evaluation. (a) Remedial action. (1) If the... another recipient exercises control over the recipient that has discriminated, the Administrator,...

  15. 22 CFR 217.6 - Remedial action, voluntary action, and self-evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Remedial action, voluntary action, and self... Provisions § 217.6 Remedial action, voluntary action, and self-evaluation. (a) Remedial action. (1) If the... another recipient exercises control over the recipient that has discriminated, the Administrator,...

  16. Choosing Actions

    PubMed Central

    Rosenbaum, David A.; Chapman, Kate M.; Coelho, Chase J.; Gong, Lanyun; Studenka, Breanna E.

    2013-01-01

    Actions that are chosen have properties that distinguish them from actions that are not. Of the nearly infinite possible actions that can achieve any given task, many of the unchosen actions are irrelevant, incorrect, or inappropriate. Others are relevant, correct, or appropriate but are disfavored for other reasons. Our research focuses on the question of what distinguishes actions that are chosen from actions that are possible but are not. We review studies that use simple preference methods to identify factors that contribute to action choices, especially for object-manipulation tasks. We can determine which factors are especially important through simple behavioral experiments. PMID:23761769

  17. Modernizing Administration.

    ERIC Educational Resources Information Center

    Lombardi, Vincent L.; Hildebrand, Verna

    1981-01-01

    Suggests assignment of research duties and rotation of teaching and management roles for college administrators, to increase their effectiveness and diminish the negative effects of declining enrollments. (JD)

  18. Intentional Action and Action Slips.

    ERIC Educational Resources Information Center

    Heckhausen, Heinz; Beckmann, Jurgen

    1990-01-01

    An explanation of action slips is offered that examines controlled actions in the context of an intentional behavior theory. Actions are considered guided by mentally represented intentions, subdivided into goal intentions and contingent instrumental intentions. Action slips are categorized according to problem areas in the enactment of goal…

  19. 5 CFR 930.113 - Corrective action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Corrective action. 930.113 Section 930....113 Corrective action. An agency will take adverse, disciplinary, or other appropriate action against... such action against an operator or an incidental operator: (a) The employee is convicted of...

  20. 48 CFR 9901.314 - Informal actions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Informal actions. 9901.314... actions. The Chairman may take actions on behalf of the Board on administrative issues, as determined by the Chairman, without holding an official meeting of the members. However, details of the actions...

  1. Administrative Support.

    ERIC Educational Resources Information Center

    Doran, Dorothy; And Others

    This guide is intended to assist business education teachers in administrative support courses. The materials presented are based on the Arizona validated occupational competencies and tasks for the occupations of receptionist, secretary, and administrative assistant. Word processing skills have been infused into each of the three sections. The…

  2. Administrative Ecology

    ERIC Educational Resources Information Center

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  3. 76 FR 65183 - National Oceanic and Atmospheric Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... National Oceanic and Atmospheric Administration National Climate Assessment and Development Advisory... Administration (NOAA), Department of Commerce (DOC). ACTION: Notice of open meeting. SUMMARY: The National... of Oceanic and Atmospheric Research, National Oceanic and Atmospheric Administration. BILLING...

  4. Environmental Action.

    ERIC Educational Resources Information Center

    Lott, Jesse; Allen, Rodney F.

    This booklet, a general guide to citizen eco-action, discusses a plan of action on community environmental problems. It offers factors to be considered in any community eco-action situation, but it is not a rigid set of rules. An overview identifies seven key ideas of environmental issues, including the universal participation of all humans in the…

  5. The [Un]Spoken Challenges of Administrator Collaboration: An Exploration of One District Leadership Team's Use of Protocols to Promote Reflection and Shared Theories of Action

    ERIC Educational Resources Information Center

    Szczesiul, Stacy Agee

    2014-01-01

    This article explores the use of protocol-structured dialogue in promoting reflective practices and shared theories of action within a district leadership team. Protocols have been used to make individuals' theories of action visible and subject to evaluation. This is important for leaders trying to establish coherence across a system; in…

  6. 78 FR 25524 - Federal Aviation Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... TRANSPORTATION Federal Aviation Administration Notice of Request To Release Airport Property AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Intent to Rule on Request to Release Airport Property..., Airports Compliance Specialist, Federal Aviation Administration, Airports Division, ACE- 610C, 901...

  7. 75 FR 68416 - Administrative Wage Garnishment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-08

    ... 31 U.S.C. 3720D(h)) with respect to administrative wage garnishment. On May 6, 1998 (63 FR 25136... CFR Part 1 Administrative Wage Garnishment AGENCY: Federal Trade Commission. ACTION: Final rule... Federal agency debt by administrative wage garnishment. Wage garnishment is a process whereby an...

  8. Neurobiological actions of cysteamine

    SciTech Connect

    Brown, M.; Fisher, L.; Mason, R.T.; Rivier, J.; Vale, W.

    1985-06-01

    Somatostatin (SS)-related peptides act within discrete brain regions to inhibit adrenal epinephrine (E) secretion, to prevent hypothermia, and to produce hyperthermia. Depletion of brain concentrations of these SS-related peptides using cysteamine (CSH) or central administration of an SS receptor antagonist increases adrenal E secretion and impairs thermoregulation. These actions of CSH and the SS receptor antagonist are reversed by administration of SS into the central nervous system. These results support the hypothesis that endogenous brain SS-related peptides are involved in the regulation of adrenal E secretion and thermoregulation.

  9. 28 CFR 902.7 - Court action.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Court action. 902.7 Section 902.7 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.7 Court action. Pursuant to Section (c) of Article XI of the Compact, a decision by...

  10. 28 CFR 902.7 - Court action.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Court action. 902.7 Section 902.7 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.7 Court action. Pursuant to Section (c) of Article XI of the Compact, a decision by...

  11. 28 CFR 902.7 - Court action.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Court action. 902.7 Section 902.7 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.7 Court action. Pursuant to Section (c) of Article XI of the Compact, a decision by...

  12. 28 CFR 902.7 - Court action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Court action. 902.7 Section 902.7 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.7 Court action. Pursuant to Section (c) of Article XI of the Compact, a decision by...

  13. 28 CFR 902.7 - Court action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Court action. 902.7 Section 902.7 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.7 Court action. Pursuant to Section (c) of Article XI of the Compact, a decision by...

  14. 28 CFR 544.44 - Disciplinary action.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Disciplinary action. 544.44 Section 544.44 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Mandatory English-as-a-Second Language Program (ESL) § 544.44 Disciplinary action. As with...

  15. 28 CFR 544.44 - Disciplinary action.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Disciplinary action. 544.44 Section 544.44 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Mandatory English-as-a-Second Language Program (ESL) § 544.44 Disciplinary action. As with...

  16. 28 CFR 544.44 - Disciplinary action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Disciplinary action. 544.44 Section 544.44 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Mandatory English-as-a-Second Language Program (ESL) § 544.44 Disciplinary action. As with...

  17. 28 CFR 544.44 - Disciplinary action.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Disciplinary action. 544.44 Section 544.44 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Mandatory English-as-a-Second Language Program (ESL) § 544.44 Disciplinary action. As with...

  18. 28 CFR 544.44 - Disciplinary action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Disciplinary action. 544.44 Section 544.44 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Mandatory English-as-a-Second Language Program (ESL) § 544.44 Disciplinary action. As with...

  19. 28 CFR 544.75 - Disciplinary action.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Disciplinary action. 544.75 Section 544.75 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Literacy Program § 544.75 Disciplinary action. As with other mandatory programs, such as...

  20. 28 CFR 544.75 - Disciplinary action.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Disciplinary action. 544.75 Section 544.75 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Literacy Program § 544.75 Disciplinary action. As with other mandatory programs, such as...

  1. 28 CFR 544.75 - Disciplinary action.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Disciplinary action. 544.75 Section 544.75 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Literacy Program § 544.75 Disciplinary action. As with other mandatory programs, such as...

  2. 28 CFR 544.75 - Disciplinary action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Disciplinary action. 544.75 Section 544.75 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Literacy Program § 544.75 Disciplinary action. As with other mandatory programs, such as...

  3. 28 CFR 544.75 - Disciplinary action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Disciplinary action. 544.75 Section 544.75 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT EDUCATION Literacy Program § 544.75 Disciplinary action. As with other mandatory programs, such as work assignments, staff may take disciplinary...

  4. Administrative IT

    ERIC Educational Resources Information Center

    Grayson, Katherine, Ed.

    2006-01-01

    When it comes to Administrative IT solutions and processes, best practices range across the spectrum. Enterprise resource planning (ERP), student information systems (SIS), and tech support are prominent and continuing areas of focus. But widespread change can also be accomplished via the implementation of campuswide document imaging and sharing,…

  5. Engineering Administration.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    This book is intended to acquaint naval engineering officers with their duties in the engineering department. Standard shipboard organizations are analyzed in connection with personnel assignments, division operations, and watch systems. Detailed descriptions are included for the administration of directives, ship's bills, damage control, training…

  6. ADMINISTRATIVE CLIMATE.

    ERIC Educational Resources Information Center

    BRUCE, ROBERT L.; CARTER, G.L., JR.

    IN THE COOPERATIVE EXTENSION SERVICE, STYLES OF LEADERSHIP PROFOUNDLY AFFECT THE QUALITY OF THE SERVICE RENDERED. ACCORDINGLY, MAJOR INFLUENCES ON ADMINISTRATIVE CLIMATE AND EMPLOYEE PRODUCTIVITY ARE EXAMINED IN ESSAYS ON (1) SOURCES OF JOB SATISFACTION AND DISSATISFACTION, (2) MOTIVATIONAL THEORIES BASED ON JOB-RELATED SATISFACTIONS AND NEEDS,…

  7. Database Administrator

    ERIC Educational Resources Information Center

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  8. 5 CFR 1201.125 - Administrative law judge.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 3 2013-01-01 2013-01-01 false Administrative law judge. 1201.125... § 1201.125 Administrative law judge. (a) An administrative law judge will hear a disciplinary action... administrative law judge will issue an initial decision on the complaint pursuant to 5 U.S.C. 557. The...

  9. Immunoglobulin G-mediated regulation of the murine immune response to transfused red blood cells occurs in the absence of active immune suppression: implications for the mechanism of action of anti-D in the prevention of haemolytic disease of the fetus and newborn?

    PubMed Central

    Brinc, Davor; Le-Tien, Hoang; Crow, Andrew R; Siragam, Vinayakumar; Freedman, John; Lazarus, Alan H

    2008-01-01

    Anti-D has been widely and effectively used in Rhesus blood group D negative mothers for the prevention of haemolytic disease of the fetus and newborn; its mechanism of action however, often referred to as antibody-mediated immune suppression (AMIS), remains largely unresolved. We investigated, in a murine model, whether active immune suppression or clonal deletion mediated by anti-red blood cell (RBC) immunoglobulin G (IgG) could explain the phenomenon of AMIS. Transfusion of IgG-opsonized foreign RBCs (i.e. AMIS) strongly attenuated antibody responses compared to transfusion of untreated foreign RBCs. When the AMIS-mice were subsequently transfused with untreated RBCs, no immune suppression was observed at 5 and 35 days after AMIS induction; in fact, the mice responded to retransfusion with untreated RBCs in a manner that was characteristic of a secondary immune response. When IgG-opsonized RBCs were transfused concurrently with untreated RBCs, a dose-dependent reduction of the antibody response was observed. This work suggests that the attenuation of the antibody responsiveness by anti-RBC IgG is not associated with active immune suppression or clonal deletion at either the T-cell or B-cell level; rather, the effect appears more characteristic of B-cell unresponsiveness to IgG-opsonized RBCs. These results may have implications for the understanding of the mechanism of action of anti-D in haemolytic disease of the fetus and newborn. PMID:18266717

  10. Action Learning.

    ERIC Educational Resources Information Center

    1996

    These four papers were presented at a symposium on action learning moderated by Lex Dilworth at the 1996 conference of the Academy of Human Resource Development. "Developing an Infrastructure for Individual and Organizational Change: Transfer of Learning from an Action Reflection Learning (ARL) Program" (ARL Inquiry) reports findings from a study…

  11. 76 FR 50740 - Draft Guidance for Industry and Food and Drug Administration Staff; Procedures for Handling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-16

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Procedures for Handling Section 522 Postmarket Surveillance Studies; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  12. 78 FR 44574 - Third Annual Food and Drug Administration Health Professional Organizations Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... HUMAN SERVICES Food and Drug Administration Third Annual Food and Drug Administration Health Professional Organizations Conference AGENCY: Food and Drug Administration, HHS. ACTION: Notice of conference. The Food and Drug Administration (FDA) is announcing a conference for representatives of...

  13. 76 FR 55928 - Food and Drug Administration Health Professional Organizations Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... HUMAN SERVICES Food and Drug Administration Food and Drug Administration Health Professional Organizations Conference AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public conference. The Food and Drug Administration (FDA) is announcing a conference for representatives of...

  14. 77 FR 47652 - Second Annual Food and Drug Administration Health Professional Organizations Conference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... HUMAN SERVICES Food and Drug Administration Second Annual Food and Drug Administration Health Professional Organizations Conference AGENCY: Food and Drug Administration, HHS. ACTION: Notice of conference. The Food and Drug Administration (FDA) is announcing a conference for representatives of...

  15. 77 FR 64794 - Membership of the Economic Development Administration Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... Economic Development Administration Membership of the Economic Development Administration Performance Review Board AGENCY: Economic Development Administration, Department of Commerce. ACTION: Notice of Membership on the Economic Development Administration's Performance Review Board Membership. SUMMARY:...

  16. 75 FR 63813 - Membership of the Economic Development Administration Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... Economic Development Administration Membership of the Economic Development Administration Performance Review Board AGENCY: Economic Development Administration, Department of Commerce. ACTION: Notice of membership on the Economic Development Administration's Performance Review Board membership. SUMMARY:...

  17. 78 FR 68025 - Membership of the Economic Development Administration Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... Economic Development Administration Membership of the Economic Development Administration Performance Review Board AGENCY: Economic Development Administration, Department of Commerce. ACTION: Notice of membership on the Economic Development Administration's Performance Review Board Membership. SUMMARY:...

  18. 76 FR 64072 - Membership of the Economic Development Administration Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-17

    ... Economic Development Administration Membership of the Economic Development Administration Performance Review Board AGENCY: Economic Development Administration, Department of Commerce. ACTION: Notice of membership on the Economic Development Administration's Performance Review Board membership. SUMMARY:...

  19. 77 FR 18716 - Transportation Security Administration Postal Zip Code Change; Technical Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... SECURITY Transportation Security Administration 49 CFR Part 1572 Transportation Security Administration Postal Zip Code Change; Technical Amendment AGENCY: Transportation Security Administration, DHS. ACTION... Achuko, Office of the Chief Counsel, TSA-2, Transportation Security Administration, 601 South 12th...

  20. 78 FR 52531 - The Presidential Commission on Election Administration (PCEA); Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... ADMINISTRATION The Presidential Commission on Election Administration (PCEA); Upcoming Public Advisory Meeting AGENCY: Office of Government-wide Policy, U.S. General Services Administration (GSA). ACTION: Meeting Notice. SUMMARY: The Presidential Commission on Election Administration (PCEA), a Federal...

  1. 78 FR 35272 - The Presidential Commission on Election Administration (PCEA); Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... ADMINISTRATION The Presidential Commission on Election Administration (PCEA); Upcoming Public Advisory Meeting AGENCY: Office of Government-wide Policy, U.S. General Services Administration (GSA). ACTION: M eeting notice. SUMMARY: The Presidential Commission on Election Administration (PCEA), a Federal...

  2. 78 FR 45200 - The Presidential Commission on Election Administration (PCEA); Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... ADMINISTRATION The Presidential Commission on Election Administration (PCEA); Upcoming Public Advisory Meeting AGENCY: Office of Government-wide Policy, U.S. General Services Administration (GSA). ACTION: Meeting Notice. SUMMARY: The Presidential Commission on Election Administration (PCEA), a Federal...

  3. 78 FR 34384 - The President's Commission on Election Administration (PCEA); Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    ... ADMINISTRATION The President's Commission on Election Administration (PCEA); Upcoming Public Advisory Meeting AGENCY: Office of Government-wide Policy, U.S. General Services Administration (GSA). ACTION: Meeting Notice. SUMMARY: The President's Commission on Election Administration (PCEA), a Federal...

  4. 14 CFR 13.11 - Administrative disposition of certain violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... TRANSPORTATION PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES Administrative Actions § 13.11... enforcement action, an appropriate official of the FAA field office responsible for processing the enforcement case or other appropriate FAA official may take administrative action in disposition of the case....

  5. 14 CFR 13.11 - Administrative disposition of certain violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... TRANSPORTATION PROCEDURAL RULES INVESTIGATIVE AND ENFORCEMENT PROCEDURES Administrative Actions § 13.11... enforcement action, an appropriate official of the FAA field office responsible for processing the enforcement case or other appropriate FAA official may take administrative action in disposition of the case....

  6. 48 CFR 9901.310 - Board action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Board action. 9901.310... PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET ADMINISTRATION RULES AND PROCEDURES 9901.310 Board action. Board action shall be by majority vote of the members present and voting, except that any vote...

  7. 29 CFR 1450.6 - Informal action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 4 2010-07-01 2010-07-01 false Informal action. 1450.6 Section 1450.6 Labor Regulations... UNITED STATES General Provisions § 1450.6 Informal action. Nothing contained in this regulation is intended to preclude utilization of informal administrative actions or remedies which may be available....

  8. 47 CFR 1.1906 - Informal action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Informal action. 1.1906 Section 1.1906... United States General Provisions § 1.1906 Informal action. Nothing contained in these regulations is intended to preclude utilization of informal administrative actions or remedies which may be...

  9. 34 CFR 303.424 - Civil action.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Civil action. 303.424 Section 303.424 Education... Civil action. Any party aggrieved by the findings and decision regarding an administrative complaint has the right to bring a civil action in State or Federal court under section 639(a)(1) of the...

  10. 34 CFR 303.424 - Civil action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Civil action. 303.424 Section 303.424 Education... Civil action. Any party aggrieved by the findings and decision regarding an administrative complaint has the right to bring a civil action in State or Federal court under section 639(a)(1) of the...

  11. 5 CFR 930.113 - Corrective action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Corrective action. 930.113 Section 930... (CONTINUED) PROGRAMS FOR SPECIFIC POSITIONS AND EXAMINATIONS (MISCELLANEOUS) Motor Vehicle Operators § 930.113 Corrective action. An agency will take adverse, disciplinary, or other appropriate action...

  12. Finding minimal action sequences with a simple evaluation of actions

    PubMed Central

    Shah, Ashvin; Gurney, Kevin N.

    2014-01-01

    Animals are able to discover the minimal number of actions that achieves an outcome (the minimal action sequence). In most accounts of this, actions are associated with a measure of behavior that is higher for actions that lead to the outcome with a shorter action sequence, and learning mechanisms find the actions associated with the highest measure. In this sense, previous accounts focus on more than the simple binary signal of “was the outcome achieved?”; they focus on “how well was the outcome achieved?” However, such mechanisms may not govern all types of behavioral development. In particular, in the process of action discovery (Redgrave and Gurney, 2006), actions are reinforced if they simply lead to a salient outcome because biological reinforcement signals occur too quickly to evaluate the consequences of an action beyond an indication of the outcome's occurrence. Thus, action discovery mechanisms focus on the simple evaluation of “was the outcome achieved?” and not “how well was the outcome achieved?” Notwithstanding this impoverishment of information, can the process of action discovery find the minimal action sequence? We address this question by implementing computational mechanisms, referred to in this paper as no-cost learning rules, in which each action that leads to the outcome is associated with the same measure of behavior. No-cost rules focus on “was the outcome achieved?” and are consistent with action discovery. No-cost rules discover the minimal action sequence in simulated tasks and execute it for a substantial amount of time. Extensive training, however, results in extraneous actions, suggesting that a separate process (which has been proposed in action discovery) must attenuate learning if no-cost rules participate in behavioral development. We describe how no-cost rules develop behavior, what happens when attenuation is disrupted, and relate the new mechanisms to wider computational and biological context. PMID:25506326

  13. Action Research Empowers School Librarians

    ERIC Educational Resources Information Center

    Robins, Jennifer

    2015-01-01

    Successful school library programs occur through careful planning and reflection. This reflective process is improved when it is applied in a systematic way through action research. The action research described in this paper enabled school librarians to reflect based on evidence, using data they had collected. This study presents examples of the…

  14. Action perception predicts action performance

    PubMed Central

    Bailey, Heather R.; Kurby, Christopher A.; Giovannetti, Tania; Zacks, Jeffrey M.

    2013-01-01

    Everyday action impairments often are observed in demented older adults, and they are common potential barriers to functional independence. We evaluated whether the ability to segment and efficiently encode activities is related to the ability to execute activities. Further, we evaluated whether brain regions important for segmentation also were important for action performance. Cognitively healthy older adults and those with very mild or mild dementia of the Alzheimer's type watched and segmented movies of everyday activities and then completed the Naturalistic Action Test. Structural MRI was used to measure volume in the dorsolateral prefrontal cortex (DLPFC), medial temporal lobes (MTL), posterior cortex, and anterior cingulate cortex (ACC). Dementia status and the ability to segment everyday activities strongly predicted naturalistic action performance, and MTL volume largely accounted for this relationship. In addition, the current results supported the Omission-Commission Model: Different cognitive and neurological mechanisms predicted different types of action error. Segmentation, dementia severity, and MTL volume predicted everyday omission errors, DLPFC volume predicted commission errors, and ACC volume predicted action additions. These findings suggest that event segmentation may be critical for effective action production, and that the segmentation and production of activities may recruit the same event representation system. PMID:23851113

  15. WHERE DOES WATERBORNE GIARDIASIS OCCUR, AND WHY

    EPA Science Inventory

    Over 60 outbreaks of waterborne giardiasis occurred in the United States between 1965 and 1982, mainly in the Northeast, the Rocky Mountain states, and the Pacific states. Outbreaks most often occurred as a result of inadequate or interrupted treatment. Disinfection problems and ...

  16. A Sophisticated Architecture Is Indeed Necessary for the Implementation of Health in All Policies but not Enough Comment on "Understanding the Role of Public Administration in Implementing Action on the Social Determinants of Health and Health Inequities".

    PubMed

    Breton, Eric

    2016-01-01

    In this commentary, I argue that beyond a sophisticated supportive architecture to facilitate implementation of actions on the social determinants of health (SDOH) and health inequities, the Health in All Policies (HiAP) project faces two main barriers: lack of awareness within policy networks on the social determinants of population health, and a tendency of health actors to neglect investing in other sectors' complex problems. PMID:27285517

  17. 5 CFR 772.102 - Interim personnel actions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Interim personnel actions. 772.102 Section 772.102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) INTERIM RELIEF General § 772.102 Interim personnel actions. When an employee or applicant for employment appeals an action to MSPB...

  18. 5 CFR 772.102 - Interim personnel actions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Interim personnel actions. 772.102 Section 772.102 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) INTERIM RELIEF General § 772.102 Interim personnel actions. When an employee or applicant for employment appeals an action to MSPB...

  19. 28 CFR 115.404 - Audit corrective action plan.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Audit corrective action plan. 115.404 Section 115.404 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Auditing and Corrective Action § 115.404 Audit corrective action plan. (a) A finding...

  20. 28 CFR 115.404 - Audit corrective action plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Audit corrective action plan. 115.404 Section 115.404 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Auditing and Corrective Action § 115.404 Audit corrective action plan. (a) A finding...

  1. 28 CFR 115.404 - Audit corrective action plan.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Audit corrective action plan. 115.404 Section 115.404 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Auditing and Corrective Action § 115.404 Audit corrective action plan. (a) A finding...

  2. Action, human.

    PubMed

    Russo, M T

    2010-01-01

    The term "human action" designates the intentional and deliberate movement that is proper and exclusive to mankind. Human action is a unified structure: knowledge, intention or volition, deliberation, decision or choice of means and execution. The integration between these dimensions appears as a task that demands strength of will to achieve the synthesis of self-possession and self-control that enables full personal realisation. Recently, the debate about the dynamism of human action has been enriched by the contribution of neurosciences. Thanks to techniques of neuroimaging, neurosciences have expanded the field of investigation to the nature of volition, to the role of the brain in decision-making processes and to the notion of freedom and responsibility. PMID:20393686

  3. Noble or Malevolent in a Moment of Dismay: How Postsecondary Students Construe and Characterize Bystander Action in School Violence Shooting Incidents

    ERIC Educational Resources Information Center

    Underhill, Dyan Whitlow

    2012-01-01

    Multiple incidents of postsecondary school shooting violence have occurred in American society--prompting concern about safety on college campuses, administrators' roles in prevention, and proactive and responsible bystander actions. Active shooter plans have become more established in educational environments, with efforts are directed…

  4. Reforming Administrator Training: Here We Go Again!

    ERIC Educational Resources Information Center

    Drury, William R.

    1989-01-01

    The National Policy Board for Educational Administration report ("Improving the Preparation of School Administrators: An Agenda for Reform") reiterates the need for program improvements for educational administrators. Obstacles to any real change occurring in the near future are pointed out. (six references) (SI)

  5. ST elevation occurring during stress testing

    PubMed Central

    Malouf, Diana; Mugmon, Marc

    2016-01-01

    A case is presented of significant reversible ST elevation occurring during treadmill testing, and the coronary anatomy and subsequent course are described, indicating that ischemia is a potential cause of this electrocardiographic finding. PMID:27124164

  6. Human external ophthalmomyiasis occurring in Barbados.

    PubMed

    Levett, P N; Brooker, L; Reifer, C; Prussia, P R; Eberhard, M L

    2004-06-01

    Human infection with the sheep nasal botfly Oestrus ovis occurs sporadically. In most cases, there is a history of a strike in the eye by the adult fly. Human O. ovis has been reported rarely from the Americas. We report the first case of O. ovis infection in the Caribbean region, which occurred in an urban area of Barbados. The patient responded to removal of the larvae from the conjunctiva and symptomatic treatment. PMID:15352754

  7. 5 CFR 1201.125 - Administrative law judge.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Administrative law judge. 1201.125 Section 1201.125 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES AND PROCEDURES Procedures for Original Jurisdiction Cases Special Counsel Disciplinary Actions § 1201.125 Administrative law judge. (a)...

  8. 49 CFR 386.54 - Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Administrative Law Judge. 386.54 Section 386.54... General Rules and Hearings § 386.54 Administrative Law Judge. (a) Powers of an Administrative Law Judge. The Administrative Law Judge may take any action and may prescribe all necessary rules and...

  9. 49 CFR 386.54 - Administrative Law Judge.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Administrative Law Judge. 386.54 Section 386.54... General Rules and Hearings § 386.54 Administrative Law Judge. (a) Powers of an Administrative Law Judge. The Administrative Law Judge may take any action and may prescribe all necessary rules and...

  10. 49 CFR 386.54 - Administrative Law Judge.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Administrative Law Judge. 386.54 Section 386.54... General Rules and Hearings § 386.54 Administrative Law Judge. (a) Powers of an Administrative Law Judge. The Administrative Law Judge may take any action and may prescribe all necessary rules and...

  11. 46 CFR 5.19 - Administrative Law Judge.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 1 2014-10-01 2014-10-01 false Administrative Law Judge. 5.19 Section 5.19 Shipping... REGULATIONS-PERSONNEL ACTION Definitions § 5.19 Administrative Law Judge. (a) An Administrative Law Judge... has delegated to Administrative Law Judges the authority to admonish, suspend, with or...

  12. 46 CFR 5.19 - Administrative Law Judge.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Administrative Law Judge. 5.19 Section 5.19 Shipping... REGULATIONS-PERSONNEL ACTION Definitions § 5.19 Administrative Law Judge. (a) An Administrative Law Judge... has delegated to Administrative Law Judges the authority to admonish, suspend, with or...

  13. 46 CFR 5.19 - Administrative Law Judge.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 1 2012-10-01 2012-10-01 false Administrative Law Judge. 5.19 Section 5.19 Shipping... REGULATIONS-PERSONNEL ACTION Definitions § 5.19 Administrative Law Judge. (a) An Administrative Law Judge... has delegated to Administrative Law Judges the authority to admonish, suspend, with or...

  14. 46 CFR 5.19 - Administrative Law Judge.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 1 2013-10-01 2013-10-01 false Administrative Law Judge. 5.19 Section 5.19 Shipping... REGULATIONS-PERSONNEL ACTION Definitions § 5.19 Administrative Law Judge. (a) An Administrative Law Judge... has delegated to Administrative Law Judges the authority to admonish, suspend, with or...

  15. Action Research

    ERIC Educational Resources Information Center

    Milton-Brkich, Katie Lynn; Shumbera, Kristen; Beran, Becky

    2010-01-01

    Defined as "any systemic inquiry conducted by teachers... for the purpose of gathering information about how their particular schools operate, how they teach, and how their students learn" (Mertler, 2009), "action research" is empowering and professional research done by teachers to inform and improves their own practices. Although there are many…

  16. 25 CFR 700.479 - Administrative review.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 2 2012-04-01 2012-04-01 false Administrative review. 700.479 Section 700.479 Indians... Discretionary Funds § 700.479 Administrative review. (a) If the Commissioners determine that implementation of... is terminated or suspended under paragraph (b) of this section may request a review of such action...

  17. 25 CFR 700.479 - Administrative review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false Administrative review. 700.479 Section 700.479 Indians... Discretionary Funds § 700.479 Administrative review. (a) If the Commissioners determine that implementation of... is terminated or suspended under paragraph (b) of this section may request a review of such action...

  18. 25 CFR 700.479 - Administrative review.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 2 2011-04-01 2011-04-01 false Administrative review. 700.479 Section 700.479 Indians... Discretionary Funds § 700.479 Administrative review. (a) If the Commissioners determine that implementation of... is terminated or suspended under paragraph (b) of this section may request a review of such action...

  19. The Reagan Administration and the Environment.

    ERIC Educational Resources Information Center

    Pomerance, Rafe; Turner, Tom

    1982-01-01

    Describes how the Reagan administration's antienvironmentalist attitudes are shown in new public policies. The authors examine the way administration appointments to environmentally sensitive agences are affecting environmental law. The response of environmental action groups to these policy changes is discussed. (AM)

  20. Faculty: Thy Administrator's Keeper? Some Evidence

    ERIC Educational Resources Information Center

    Cunningham, Brendan M.

    2009-01-01

    Colleges and universities face a principal-agent problem. There are information asymmetries over the actions chosen by administrators. Because non-profit constraints limit the financial stake of trustees there may be insufficient monitoring of administrators and, consequentially, shirking. It is conceivable that faculty will serve as "delegated…

  1. 32 CFR 1602.2 - Administrative classification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Administrative classification. 1602.2 Section 1602.2 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.2 Administrative classification. A reclassification action relating to a registrant's...

  2. 49 CFR 385.711 - Administrative review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Safety Monitoring System for Non-North American Carriers § 385.711 Administrative review. (a) A non-North... new entrant registration and include any information or documents that support its argument. (d) FMCSA... review. The Associate Administrator's decision will constitute the final Agency action....

  3. 49 CFR 385.711 - Administrative review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Safety Monitoring System for Non-North American Carriers § 385.711 Administrative review. (a) A non-North... new entrant registration and include any information or documents that support its argument. (d) FMCSA... review. The Associate Administrator's decision will constitute the final Agency action....

  4. 10 CFR 835.704 - Administrative records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Administrative records. 835.704 Section 835.704 Energy DEPARTMENT OF ENERGY OCCUPATIONAL RADIATION PROTECTION Records § 835.704 Administrative records. (a) Training records shall be maintained, as necessary, to demonstrate compliance with §§ 835.901. (b) Actions taken...

  5. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  6. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  7. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  8. 48 CFR 522.804 - Affirmative action programs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false Affirmative action programs. 522.804 Section 522.804 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION... Affirmative action programs....

  9. ORD Strategic Action Plan for Information Management / Information Technology 2011

    EPA Science Inventory

    ORD's Strategic Action Plan for IM/IT (2011) was collaboratively developed with input from ORD research and administrative personnel. It identifies actions necessary to support ORD's priority IM and IT needs.

  10. 28 CFR 104.61 - Limitation on civil actions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Limitation on civil actions. 104.61... COMPENSATION FUND OF 2001 Limitations § 104.61 Limitation on civil actions. (a) General. Section 405(c)(3)(B... to file a civil action (or be a party to an action) in any Federal or State court for...

  11. 28 CFR 104.61 - Limitation on civil actions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Limitation on civil actions. 104.61... COMPENSATION FUND Limitations § 104.61 Limitation on civil actions. (a) General. Section 405(c)(3)(C) of the... a civil action (or be a party to an action) in any Federal or State court for damages sustained as...

  12. Citizen's actions

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The role played by individual citizens as consumers of energy was examined, with emphasis on studying ways in which their action could result in energy conservation. It was shown that there are ways that energy can be conserved in this way, with citizens acting either individually or in groups. The potential savings are significant, but the actual savings may be quite small. The citizens need to be motivated to save and to believe in a conservation ethic; developing such an ethic is difficult, and perhaps not responsive to the shotgun approach now being attempted. The true course of action may be to synthesize new societal structures that provide the maximum evolution of culture within the limitation of scarce energy resources.

  13. Actionable Nuggets

    PubMed Central

    McColl, Mary Ann; Aiken, Alice; Smith, Karen; McColl, Alexander; Green, Michael; Godwin, Marshall; Birtwhistle, Richard; Norman, Kathleen; Brankston, Gabrielle; Schaub, Michael

    2015-01-01

    Abstract Objective To present the results of a pilot study of an innovative methodology for translating best evidence about spinal cord injury (SCI) for family practice. Design Review of Canadian and international peer-reviewed literature to develop SCI Actionable Nuggets, and a mixed qualitative-quantitative evaluation to determine Nuggets’ effect on physician knowledge of and attitudes toward patients with SCI, as well as practice accessibility. Setting Ontario, Newfoundland, and Australia. Participants Forty-nine primary care physicians. Methods Twenty Actionable Nuggets (pertaining to key health issues associated with long-term SCI) were developed. Nugget postcards were mailed weekly for 20 weeks to participating physicians. Prior knowledge of SCI was self-rated by participants; they also completed an online posttest to assess the information they gained from the Nugget postcards. Participants’ opinions about practice accessibility and accommodations for patients with SCI, as well as the acceptability and usefulness of Nuggets, were assessed in interviews. Main findings With Actionable Nuggets, participants’ knowledge of the health needs of patients with SCI improved, as knowledge increased from a self-rating of fair (58%) to very good (75%) based on posttest quiz results. The mean overall score for accessibility and accommodations in physicians’ practices was 72%. Participants’ awareness of the need for screening and disease prevention among this population also increased. The usefulness and acceptability of SCI Nugget postcards were rated as excellent. Conclusion Actionable Nuggets are a knowledge translation tool designed to provide family physicians with concise, practical information about the most prevalent and pressing primary care needs of patients with SCI. This evidence-based resource has been shown to be an excellent fit with information consumption processes in primary care. They were updated and adapted for distribution by the Canadian

  14. Androgen action.

    PubMed

    Werner, Ralf; Holterhus, Paul-Martin

    2014-01-01

    Androgens are important for male sex development and physiology. Their actions are mediated by the androgen receptor (AR), a ligand-dependent nuclear transcription factor. The activity of the AR is controlled at multiple stages due to ligand binding and induced structural changes assisted by the foldosome, compartmentalization, recruitment of coregulators, posttranslational modifications and chromatin remodeling, leading to subsequent transcription of androgen-responsive target genes. Beside these short-term androgen actions, there is phenomenological and experimental evidence of long-term androgen programming in mammals and in the human during sensitive programming time windows, both pre- and postnatally. At the molecular level, research into androgen insensitivity syndrome has unmasked androgen programming at the transcriptome level, in genital fibroblasts and peripheral blood mononuclear cells, and at the epigenome level. Androgens are crucial for male sex development and physiology during embryogenesis, at puberty and in adult life. Testosterone and its more potent metabolite, dihydrotestosterone, which is converted from testosterone within the target cell by 5α-reductase II, are the main androgens involved in male sex differentiation. Androgen action is mediated by a single AR. The AR belongs to the nuclear receptor 3 group C, composed of the glucocorticoid receptor (NR3C1), mineralocorticoid receptor (NR3C2), progesterone receptor (NR3C3) and AR (NR3C4), and acts as a ligand-dependent transcription factor. PMID:25247642

  15. 49 CFR 385.105 - Expedited action.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY FITNESS PROCEDURES Safety Monitoring System for Mexico-Domiciled Carriers § 385.105 Expedited action. (a) A...

  16. 49 CFR 385.105 - Expedited action.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY FITNESS PROCEDURES Safety Monitoring System for Mexico-Domiciled Carriers § 385.105 Expedited action. (a) A...

  17. 49 CFR 385.105 - Expedited action.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS SAFETY FITNESS PROCEDURES Safety Monitoring System for Mexico-Domiciled Carriers § 385.105 Expedited action. (a) A...

  18. Young Children's Reports of when Learning Occurred

    ERIC Educational Resources Information Center

    Tang, Connie M.; Bartsch, Karen; Nunez, Narina

    2007-01-01

    This study investigated young children's reports of when learning occurred. A total of 96 4-, 5-, and 6-year-olds were recruited from suburban preschools and elementary schools. The children learned an animal fact and a body movement. A week later, children learned another animal fact and another body movement and then answered questions about…

  19. Phonetic Recalibration Only Occurs in Speech Mode

    ERIC Educational Resources Information Center

    Vroomen, Jean; Baart, Martijn

    2009-01-01

    Upon hearing an ambiguous speech sound dubbed onto lipread speech, listeners adjust their phonetic categories in accordance with the lipread information (recalibration) that tells what the phoneme should be. Here we used sine wave speech (SWS) to show that this tuning effect occurs if the SWS sounds are perceived as speech, but not if the sounds…

  20. 77 FR 3836 - Public Availability of Social Security Administration Fiscal Year (FY) 2011 Service Contract...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Public Availability of Social Security Administration Fiscal Year (FY) 2011 Service Contract Inventory AGENCY: Social Security Administration. ACTION: Notice of Public Availability of FY 2011...

  1. 75 FR 44163 - Antidumping and Countervailing Duty Proceedings: Electronic Filing Procedures; Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures AGENCY: Import Administration, International Trade Administration, Department of Commerce. ACTION: Proposed Rule; Request...

  2. 75 FR 64389 - Proposed Recommendation to the Social Security Administration for Occupational Information System...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-19

    ... From the Federal Register Online via the Government Publishing Office ] SOCIAL SECURITY ADMINISTRATION Proposed Recommendation to the Social Security Administration for Occupational Information System (OIS) Development Planning; Request for Comment AGENCY: Social Security Administration. ACTION:...

  3. 78 FR 73863 - Public Availability of General Services Administration FY 2013 Federal Activities Inventory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-09

    ... ADMINISTRATION Public Availability of General Services Administration FY 2013 Federal Activities Inventory Reform (FAIR) Act Inventory AGENCY: General Services Administration (GSA). ACTION: Notice of public availability of FY 2013 Federal Activities Inventory Reform (FAIR) Act Inventory. SUMMARY: In accordance...

  4. 77 FR 54917 - Public Availability of General Services Administration FY 2012 Federal Activities Inventory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... ADMINISTRATION Public Availability of General Services Administration FY 2012 Federal Activities Inventory Reform (FAIR) Act Inventory AGENCY: General Services Administration (GSA). ACTION: Notice of Public Availability of Fiscal Year (FY) 2012 Federal Activities Inventory Reform (FAIR) Act Inventory. SUMMARY:...

  5. Young children's reports of when learning occurred.

    PubMed

    Tang, Connie M; Bartsch, Karen; Nunez, Narina

    2007-06-01

    This study investigated young children's reports of when learning occurred. A total of 96 4-, 5-, and 6-year-olds were recruited from suburban preschools and elementary schools. The children learned an animal fact and a body movement. A week later, children learned another animal fact and another body movement and then answered questions about when the different learning events occurred. Responses of children who responded correctly to control questions about time supported the hypothesis that temporal distance questions would elicit more correct responses than would temporal location questions. Partial support was also found for the hypothesis that behavior learning would generate more correct reports than would fact learning. Implications for characterizations of children's developing understanding of knowledge and for applications of those characterizations in education and eyewitness testimony are discussed. PMID:17346740

  6. Changes in joint laxity occurring during pregnancy.

    PubMed Central

    Calguneri, M; Bird, H A; Wright, V

    1982-01-01

    We have studied changes in peripheral joint laxity occurring during pregnancy in 68 females using both the finger hyperextensometer to quantify laxity at the metacarpophalangeal joint of the index finger and Beighton et al.'s modification of the Carter and Wilkinson scoring system. Although the latter system recorded no change, the more sensitive hyperextensometer demonstrated a significant increase in joint laxity during the last trimester of pregnancy (0.02 greater than p greater than 0.01) over the readings from the same individuals after parturition. When primigravidae and multigravidae were compared, a highly significant increase in laxity was found in women having their second baby over those having their first (0.01 greater than p greater than 0.001), though no further increase in laxity occurred in subsequent pregnancies. PMID:7073339

  7. Synthesis of Naturally Occurring Tropones and Tropolones

    PubMed Central

    Liu, Na; Song, Wangze; Schienebeck, Casi M.; Zhang, Min; Tang, Weiping

    2014-01-01

    Tropones and tropolones are an important class of seven-membered non-benzenoid aromatic compounds. They can be prepared directly by oxidation of seven-membered rings. They can also be derived from cyclization or cycloaddition of appropriate precursors followed by elimination or rearrangement. This review discusses the types of naturally occurring tropones and tropolones and outlines important methods developed for the synthesis of tropone and tropolone natural products. PMID:25400298

  8. Action Learning: Avoiding Conflict or Enabling Action

    ERIC Educational Resources Information Center

    Corley, Aileen; Thorne, Ann

    2006-01-01

    Action learning is based on the premise that action and learning are inextricably entwined and it is this potential, to enable action, which has contributed to the growth of action learning within education and management development programmes. However has this growth in action learning lead to an evolution or a dilution of Revan's classical…

  9. 23 CFR 140.605 - Approval actions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Approval actions. 140.605 Section 140.605 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PAYMENT PROCEDURES REIMBURSEMENT Reimbursement for Bond Issue Projects § 140.605 Approval actions. (a) Authorization to proceed with...

  10. 18 CFR 401.7 - Further action.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Further action. 401.7 Section 401.7 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Comprehensive Plan § 401.7 Further action. The Commission...

  11. Outdoor Recreation Action. Report No. 10

    ERIC Educational Resources Information Center

    Bureau of Outdoor Recreation (Dept. of Interior), Washington, DC.

    Actions taken in the area of outdoor recreation on Federal, State, local, and private levels are reported in the document. Financing actions are listed according to states, government agencies, and names of private financers. The organization and administration section includes new agencies, personnel, reorganizations, and significant resolutions…

  12. Naturally occurring products in cancer therapy

    PubMed Central

    Rajesh, E.; Sankari, Leena S.; Malathi, L.; Krupaa, Jayasri R.

    2015-01-01

    Natural products have been used for the treatment of various diseases and are becoming an important research area for drug discovery. These products, especially phytochemicals have been extensively studies and have exhibited anti-carcinogenic activities by interfering with the initiation, development and progression of cancer through the modulation of various mechanisms including cellular proliferation, differentiation, apoptosis, angiogenesis, and metastasis. This concept is gaining attention because it is a cost-effective alternative to cancer treatment. In this article, we have discussed some of the naturally occurring products used in cancer treatment. PMID:26015704

  13. Naturally occurring anti M complicating ABO grouping.

    PubMed

    Khalid, Safoorah; Dantes, Roelyn; Varghese, Sunu; Al Hakawati, Imadeddin

    2011-01-01

    Anti M is considered a naturally occurring antibody that is usually active at temperatures below 37°C and is thus of no clinical significance. This antibody, if present in an individual, can lead to a discrepancy between forward and reverse ABO grouping and thus creates diagnostic difficulties for blood bank staff. We report a case of a 58-year-old lady who had an unexpected reaction in reverse grouping due to anti M that posed a problem for us in the interpretation of results of her blood group. We also reviewed the literature to find out the significance of such discrepancy in blood grouping. PMID:21393909

  14. Quality in Action: Closing the Loop

    ERIC Educational Resources Information Center

    Nair, Chenicheri Sid; Pawley, David; Mertova, Patricie

    2010-01-01

    Purpose: This paper aims to report on how an Administrative Division at a research-intensive Australian university utilised feedback data from the Learning and Growth Survey, to initiate changes. Design/methodology/approach: This paper refers to the actions taken by the Administrative Division to the results obtained from the Learning and Growth…

  15. Action selection and action value in frontal-striatal circuits

    PubMed Central

    Seo, Moonsang; Lee, Eunjeong; Averbeck, Bruno B.

    2012-01-01

    Summary The role that frontal-striatal circuits play in normal behavior remains unclear. Two of the leading hypotheses suggest that these circuits are important for action selection or reinforcement learning. To examine these hypotheses we carried out an experiment in which monkeys had to select actions in two different task conditions. In the first (random) condition actions were selected on the basis of perceptual inference. In the second (fixed) condition the animals used reinforcement from previous trials to select actions. Examination of neural activity showed that the representation of the selected action was stronger in lateral prefrontal cortex (lPFC), and occurred earlier in the lPFC than it did in the dorsal striatum (dSTR). In contrast to this, the representation of action values, in both the random and fixed conditions was stronger in the dSTR. Thus, the dSTR contains an enriched representation of action value, but it followed frontal cortex in action selection. PMID:22681697

  16. Nipah virus entry can occur by macropinocytosis

    SciTech Connect

    Pernet, Olivier; Pohl, Christine; Ainouze, Michelle; Kweder, Hasan; Buckland, Robin

    2009-12-20

    Nipah virus (NiV) is a zoonotic biosafety level 4 paramyxovirus that emerged recently in Asia with high mortality in man. NiV is a member, with Hendra virus (HeV), of the Henipavirus genus in the Paramyxoviridae family. Although NiV entry, like that of other paramyxoviruses, is believed to occur via pH-independent fusion with the host cell's plasma membrane we present evidence that entry can occur by an endocytic pathway. The NiV receptor ephrinB2 has receptor kinase activity and we find that ephrinB2's cytoplasmic domain is required for entry but is dispensable for post-entry viral spread. The mutation of a single tyrosine residue (Y304F) in ephrinB2's cytoplasmic tail abrogates NiV entry. Moreover, our results show that NiV entry is inhibited by constructions and drugs specific for the endocytic pathway of macropinocytosis. Our findings could potentially permit the rapid development of novel low-cost antiviral treatments not only for NiV but also HeV.

  17. Collaborating and Advocating with Administrators: The Arkansas Gifted Education Administrators' Story

    ERIC Educational Resources Information Center

    Robinson, Ann

    2003-01-01

    Empirical research on the philosophies, beliefs, and actions of school administrators such as principals or superintendents toward talented students is largely nonexistent in the published literature. What little is known suggests that administrators are crucial, but that advocates of services for high-ability learners need to carry the message…

  18. Brain regions mediating α3β4 nicotinic antagonist effects of 18-MC on nicotine self-administration.

    PubMed

    Glick, Stanley D; Sell, Elizabeth M; McCallum, Sarah E; Maisonneuve, Isabelle M

    2011-11-01

    18-Methoxycoronaridine (18-MC), a putative anti-addictive agent, has been shown to decrease the self-administration of several drugs of abuse in rats. 18-MC is a potent antagonist at α3β4 nicotinic receptors. Consistent with high densities of α3β4 nicotinic receptors being located in the medial habenula and the interpeduncular nucleus, 18-MC has been shown to act in these regions to decrease both morphine and methamphetamine self-administration. The present study was conducted to determine if 18-MC's effect on nicotine self-administration is mediated by acting in these same brain regions. Because moderate densities of α3β4 receptors occur in the dorsolateral tegmentum, ventral tegmental area, and basolateral amygdala, these brain areas were also examined as potential sites of action of 18-MC. Local administration of 18-MC into either the medial habenula, the basolateral amygdala or the dorsolateral tegmentum decreased nicotine self-administration. Surprisingly, local administration of 18-MC into the interpeduncular nucleus increased nicotine self-administration while local administration of 18-MC into the ventral tegmental area had no effect on nicotine self-administration. Similar effects were produced by local administration of either mecamylamine or conotoxin AuIB. These data are consistent with the hypothesis that 18-MC decreases nicotine self-administration by indirectly modulating the dopaminergic mesolimbic pathway via blockade of α3β4 nicotinic receptors in the medial habenula, basolateral amygdala, and dorsolateral tegmentum. The data also suggest that an action of 18-MC in the interpeduncular nucleus may attenuate aversive and/or depressive effects of nicotine. PMID:21871879

  19. Senior Administrators Should Have Administrative Contracts.

    ERIC Educational Resources Information Center

    Posner, Gary J.

    1987-01-01

    Recognizing that termination is viewed by the employee as the equivalent to capital punishment of a career, an administrative contract can reduce the emotional and financial entanglements that often result. Administrative contracts are described. (MLW)

  20. Novice Administrators: Personality and Administrative Style Changes.

    ERIC Educational Resources Information Center

    Schmidt, Linda J.; Kosmoski, Georgia J.; Pollack, Dennis R.

    Since the advent of effective-schools research findings, educational administration experts have advocated a democratic and collegial leadership style for school administrators. This paper provides the findings of a study that examined 43 beginning administrators (25 females, 32 Caucasians, 9 African-Americans, 2 Hispanics) to determine what…

  1. Corrective Action Decision Document/Corrective Action Plan for Corrective Action Unit 547: Miscellaneous Contaminated Waste Sites, Nevada National Security Site, Nevada, Revision 0

    SciTech Connect

    Mark Krauss

    2011-09-01

    The purpose of this CADD/CAP is to present the corrective action alternatives (CAAs) evaluated for CAU 547, provide justification for selection of the recommended alternative, and describe the plan for implementing the selected alternative. Corrective Action Unit 547 consists of the following three corrective action sites (CASs): (1) CAS 02-37-02, Gas Sampling Assembly; (2) CAS 03-99-19, Gas Sampling Assembly; and(3) CAS 09-99-06, Gas Sampling Assembly. The gas sampling assemblies consist of inactive process piping, equipment, and instrumentation that were left in place after completion of underground safety experiments. The purpose of these safety experiments was to confirm that a nuclear explosion would not occur in the case of an accidental detonation of the high-explosive component of the device. The gas sampling assemblies allowed for the direct sampling of the gases and particulates produced by the safety experiments. Corrective Action Site 02-37-02 is located in Area 2 of the Nevada National Security Site (NNSS) and is associated with the Mullet safety experiment conducted in emplacement borehole U2ag on October 17, 1963. Corrective Action Site 03-99-19 is located in Area 3 of the NNSS and is associated with the Tejon safety experiment conducted in emplacement borehole U3cg on May 17, 1963. Corrective Action Site 09-99-06 is located in Area 9 of the NNSS and is associated with the Player safety experiment conducted in emplacement borehole U9cc on August 27, 1964. The CAU 547 CASs were investigated in accordance with the data quality objectives (DQOs) developed by representatives of the Nevada Division of Environmental Protection (NDEP) and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to determine and implement appropriate corrective actions for CAU 547. Existing radiological survey data and historical knowledge of

  2. 77 FR 31298 - Information Collection; Special Use Administration

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... Forest Service Information Collection; Special Use Administration AGENCY: Forest Service, USDA. ACTION... revision of a currently approved information collection, Special Use Administration. DATES: Comments must...: Special Use Administration. OMB Number: 0596-0082. Expiration Date of Approval: October 31, 2012. Type...

  3. 27 CFR 71.109 - Notice to Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Notice to Administrator... Decisions Action by the Appropriate Ttb Officer § 71.109 Notice to Administrator. When the appropriate TTB... of the decision on which it is based to the Administrator. Should such order be subsequently...

  4. 28 CFR 71.44 - Right to administrative offset.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Right to administrative offset. 71.44 Section 71.44 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 Implementation for Actions Initiated by the Department of Justice § 71.44 Right to...

  5. 28 CFR 71.44 - Right to administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Right to administrative offset. 71.44 Section 71.44 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 Implementation for Actions Initiated by...

  6. 28 CFR 71.44 - Right to administrative offset.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Right to administrative offset. 71.44 Section 71.44 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 Implementation for Actions Initiated by...

  7. 28 CFR 71.44 - Right to administrative offset.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Right to administrative offset. 71.44 Section 71.44 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 Implementation for Actions Initiated by...

  8. 28 CFR 71.44 - Right to administrative offset.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Right to administrative offset. 71.44 Section 71.44 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) IMPLEMENTATION OF THE PROVISIONS OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 Implementation for Actions Initiated by...

  9. 18 CFR 808.3 - Hearings on administrative appeal.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... administrative appeal. 808.3 Section 808.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION HEARINGS AND ENFORCEMENT ACTIONS Conduct of Hearings § 808.3 Hearings on administrative appeal. (a) Unless otherwise agreed to by the Commission and the party requesting an administrative appeal...

  10. 18 CFR 808.3 - Hearings on administrative appeal.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... administrative appeal. 808.3 Section 808.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION HEARINGS AND ENFORCEMENT ACTIONS Conduct of Hearings § 808.3 Hearings on administrative appeal. (a) Unless otherwise agreed to by the Commission and the party requesting an administrative appeal...

  11. 18 CFR 808.3 - Hearings on administrative appeal.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... administrative appeal. 808.3 Section 808.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION HEARINGS AND ENFORCEMENT ACTIONS Conduct of Hearings § 808.3 Hearings on administrative appeal. (a) Unless otherwise agreed to by the Commission and the party requesting an administrative appeal...

  12. 18 CFR 808.3 - Hearings on administrative appeal.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... administrative appeal. 808.3 Section 808.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION HEARINGS AND ENFORCEMENT ACTIONS Conduct of Hearings § 808.3 Hearings on administrative appeal. (a) Unless otherwise agreed to by the Commission and the party requesting an administrative appeal...

  13. 18 CFR 808.3 - Hearings on administrative appeal.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... administrative appeal. 808.3 Section 808.3 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION HEARINGS AND ENFORCEMENT ACTIONS Conduct of Hearings § 808.3 Hearings on administrative appeal. (a) Unless otherwise agreed to by the Commission and the party requesting an administrative appeal...

  14. 27 CFR 71.109 - Notice to Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false Notice to Administrator... Decisions Action by the Appropriate Ttb Officer § 71.109 Notice to Administrator. When the appropriate TTB... of the decision on which it is based to the Administrator. Should such order be subsequently...

  15. 27 CFR 71.109 - Notice to Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Notice to Administrator... Decisions Action by the Appropriate Ttb Officer § 71.109 Notice to Administrator. When the appropriate TTB... of the decision on which it is based to the Administrator. Should such order be subsequently...

  16. 42 CFR 417.124 - Administration and management.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Administration and management. 417.124 Section 417....124 Administration and management. (a) General requirements. Each HMO must have administrative and... management actions are in the best interest of the HMO and its enrollees. (2) Personnel and...

  17. 42 CFR 417.124 - Administration and management.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Administration and management. 417.124 Section 417....124 Administration and management. (a) General requirements. Each HMO must have administrative and... management actions are in the best interest of the HMO and its enrollees. (2) Personnel and...

  18. 42 CFR 417.124 - Administration and management.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 3 2014-10-01 2014-10-01 false Administration and management. 417.124 Section 417....124 Administration and management. (a) General requirements. Each HMO must have administrative and... management actions are in the best interest of the HMO and its enrollees. (2) Personnel and...

  19. 78 FR 70959 - Commission on Indian Trust Administration and Reform

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... Office of the Secretary Commission on Indian Trust Administration and Reform AGENCY: Office of the Secretary, Interior. ACTION: Notice of Renewal of the Commission on Indian Trust Administration and Reform. SUMMARY: Following consultation with the General Services Administration, notice is hereby given that...

  20. Introduction to naturally occurring radioactive material

    SciTech Connect

    Egidi, P.

    1997-08-01

    Naturally occurring radioactive material (NORM) is everywhere; we are exposed to it every day. It is found in our bodies, the food we eat, the places where we live and work, and in products we use. We are also bathed in a sea of natural radiation coming from the sun and deep space. Living systems have adapted to these levels of radiation and radioactivity. But some industrial practices involving natural resources concentrate these radionuclides to a degree that they may pose risk to humans and the environment if they are not controlled. Other activities, such as flying at high altitudes, expose us to elevated levels of NORM. This session will concentrate on diffuse sources of technologically-enhanced (TE) NORM, which are generally large-volume, low-activity waste streams produced by industries such as mineral mining, ore benefication, production of phosphate Fertilizers, water treatment and purification, and oil and gas production. The majority of radionuclides in TENORM are found in the uranium and thorium decay chains. Radium and its subsequent decay products (radon) are the principal radionuclides used in characterizing the redistribution of TENORM in the environment by human activity. We will briefly review other radionuclides occurring in nature (potassium and rubidium) that contribute primarily to background doses. TENORM is found in many waste streams; for example, scrap metal, sludges, slags, fluids, and is being discovered in industries traditionally not thought of as affected by radionuclide contamination. Not only the forms and volumes, but the levels of radioactivity in TENORM vary. Current discussions about the validity of the linear no dose threshold theory are central to the TENORM issue. TENORM is not regulated by the Atomic Energy Act or other Federal regulations. Control and regulation of TENORM is not consistent from industry to industry nor from state to state. Proposed regulations are moving from concentration-based standards to dose

  1. Thinking on Your Feet: Principals' Reflection-in-Action

    ERIC Educational Resources Information Center

    Bond, John

    2011-01-01

    In this study the reflection-in-action of experienced school principals was investigated. While reflection-on-action occurs after-the-fact, reflection-in-action is situated in the context of action. This qualitative study explores what principals think about as they are in the midst of dealing with an unexpected public confrontation. The purpose…

  2. 12 CFR 790.3 - Requests for action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Requests for action. 790.3 Section 790.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT UNION ADMINISTRATION DESCRIPTION OF NCUA; REQUESTS FOR AGENCY ACTION § 790.3 Requests for...

  3. 12 CFR 790.3 - Requests for action.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Requests for action. 790.3 Section 790.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT UNION ADMINISTRATION DESCRIPTION OF NCUA; REQUESTS FOR AGENCY ACTION § 790.3 Requests for...

  4. 12 CFR 790.3 - Requests for action.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Requests for action. 790.3 Section 790.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT UNION ADMINISTRATION DESCRIPTION OF NCUA; REQUESTS FOR AGENCY ACTION § 790.3 Requests for...

  5. 12 CFR 790.3 - Requests for action.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Requests for action. 790.3 Section 790.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT UNION ADMINISTRATION DESCRIPTION OF NCUA; REQUESTS FOR AGENCY ACTION § 790.3 Requests for...

  6. 12 CFR 790.3 - Requests for action.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Requests for action. 790.3 Section 790.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT UNION ADMINISTRATION DESCRIPTION OF NCUA; REQUESTS FOR AGENCY ACTION § 790.3 Requests for...

  7. 5 CFR 317.1001 - OPM authority for corrective action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false OPM authority for corrective action. 317.1001 Section 317.1001 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT IN THE SENIOR EXECUTIVE SERVICE Corrective Action § 317.1001 OPM authority for corrective...

  8. 5 CFR 1205.22 - Action on request.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Action on request. 1205.22 Section 1205.22 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRIVACY ACT REGULATIONS Amendment of Records § 1205.22 Action on request. (a) Amendment granted. If the Board grants...

  9. 5 CFR 1630.6 - Action on request.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 3 2012-01-01 2012-01-01 false Action on request. 1630.6 Section 1630.6 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD PRIVACY ACT REGULATIONS § 1630.6 Action on request. (a) For TSP records, the record keeper designee, and for non-TSP records, the Privacy Act...

  10. 18 CFR 401.89 - Action by the Commission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Action by the Commission. 401.89 Section 401.89 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION ADMINISTRATIVE MANUAL RULES OF PRACTICE AND PROCEDURE Administrative and Other Hearings § 401.89 Action by...

  11. Student Voice in High School: An Action Research Study

    ERIC Educational Resources Information Center

    Termini, Lorraine

    2013-01-01

    This action research study examined the effects of student voice in one high school and the self-reflection of the researcher-administrator involved in the effort. Using three cycles of action research, the researcher-administrator completed a pilot study, implemented a student voice project in one class, and developed a professional development…

  12. 28 CFR 902.4 - Action by Council Chairman.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Action by Council Chairman. 902.4 Section 902.4 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.4 Action by Council Chairman. (a) The Chairman shall communicate the decision...

  13. 28 CFR 902.4 - Action by Council Chairman.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Action by Council Chairman. 902.4 Section 902.4 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.4 Action by Council Chairman. (a) The Chairman shall communicate the decision...

  14. 28 CFR 902.4 - Action by Council Chairman.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Action by Council Chairman. 902.4 Section 902.4 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.4 Action by Council Chairman. (a) The Chairman shall communicate the decision...

  15. 28 CFR 902.4 - Action by Council Chairman.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Action by Council Chairman. 902.4 Section 902.4 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.4 Action by Council Chairman. (a) The Chairman shall communicate the decision...

  16. 28 CFR 902.4 - Action by Council Chairman.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Action by Council Chairman. 902.4 Section 902.4 Judicial Administration NATIONAL CRIME PREVENTION AND PRIVACY COMPACT COUNCIL DISPUTE ADJUDICATION PROCEDURES § 902.4 Action by Council Chairman. (a) The Chairman shall communicate the decision...

  17. 20 CFR 658.703 - Emergency corrective action.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Emergency corrective action. 658.703 Section 658.703 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) ADMINISTRATIVE PROVISIONS GOVERNING THE JOB SERVICE SYSTEM Federal Application of Remedial Action to...

  18. 5 CFR 315.909 - Relationship to other actions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Relationship to other actions. 315.909 Section 315.909 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS CAREER... Position § 315.909 Relationship to other actions. (a) If an employee is required to concurrently serve...

  19. 5 CFR 250.103 - Consequences of improper agency actions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Consequences of improper agency actions. 250.103 Section 250.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Authority for Personnel Actions in Agencies §...

  20. 5 CFR 250.103 - Consequences of improper agency actions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Consequences of improper agency actions. 250.103 Section 250.103 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PERSONNEL MANAGEMENT IN AGENCIES Authority for Personnel Actions in Agencies §...