Science.gov

Sample records for administrative protective order

  1. 19 CFR 351.103 - Central Records Unit and Administrative Protective Order and Dockets Unit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Central Records Unit and Administrative Protective..., DEPARTMENT OF COMMERCE ANTIDUMPING AND COUNTERVAILING DUTIES Scope and Definitions § 351.103 Central Records Unit and Administrative Protective Order and Dockets Unit. (a) Import Administration's Central...

  2. 19 CFR 351.103 - Central Records Unit and Administrative Protective Order and Dockets Unit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... protective orders (APOs), maintaining the APO service list and the public service list as provided for in... list. The APO/Dockets Unit will maintain and make available a public service list for each segment of a... exception of a petitioner filing a petition in an investigation, to be included on the public service...

  3. 14 CFR 17.9 - Protective orders.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... protective orders addressing the treatment of protected information, including protected information in... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Protective orders. 17.9 Section 17.9 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PROCEDURAL...

  4. 14 CFR 1264.123 - Protective order.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Protective order. 1264.123 Section 1264.123 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL PENALTIES ACT OF 1986 § 1264.123 Protective order. (a) A party or a prospective witness or deponent may...

  5. 21 CFR 17.28 - Protective order.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Protective order. 17.28 Section 17.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL CIVIL MONEY... protective order with respect to discovery sought by a party or with respect to the hearing, seeking to...

  6. 21 CFR 17.28 - Protective order.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Protective order. 17.28 Section 17.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL CIVIL MONEY... protective order with respect to discovery sought by a party or with respect to the hearing, seeking to...

  7. 21 CFR 17.28 - Protective order.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Protective order. 17.28 Section 17.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL CIVIL MONEY... protective order with respect to discovery sought by a party or with respect to the hearing, seeking to...

  8. 21 CFR 17.28 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Protective order. 17.28 Section 17.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL CIVIL MONEY... protective order with respect to discovery sought by a party or with respect to the hearing, seeking to...

  9. 21 CFR 17.28 - Protective order.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Protective order. 17.28 Section 17.28 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL CIVIL MONEY... protective order with respect to discovery sought by a party or with respect to the hearing, seeking to...

  10. Localization protected quantum order

    NASA Astrophysics Data System (ADS)

    Nandkishore, Rahul

    2015-03-01

    Many body localization occurs in isolated quantum systems, usually with strong disorder, and is marked by absence of dissipation, absence of thermal equilibration, and a memory of the initial conditions that survives in local observables for arbitrarily long times. The many body localized regime is a non-equilibrium, strongly disordered, non-self averaging regime that presents a new frontier for quantum statistical mechanics. In this talk, I point out that there exists a vast zoo of correlated many body localized states of matter, which may be classified using familiar notions of spontaneous symmetry breaking and topological order. I will point out that in the many body localized regime, spontaneous symmetry breaking can occur even at high energy densities in one dimensional systems, and topological order can occur even without a bulk gap. I will also discuss the phenomenology of imperfectly isolated many body localized systems, which are weakly coupled to a heat bath. I will conclude with a brief discussion of how these phenomena may best be detected in experiments. Collaborators: David Huse, S.L. Sondhi, Arijeet Pal, Vadim Oganesyan, A.C. Potter, Sarang Gopalakrishnan, S. Johri, R.N. Bhatt.

  11. 45 CFR 79.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Protective order. 79.24 Section 79.24 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79... being sealed be opened only by order of the ALJ; (8) That a trade secret or other confidential...

  12. 28 CFR 68.42 - In camera and protective orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false In camera and protective orders. 68.42... In camera and protective orders. (a) Privileged communications. Upon application of any person, the.... Such arrangements may include obtaining security clearances or giving counsel for a party access...

  13. 29 CFR 18.46 - In camera and protective orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false In camera and protective orders. 18.46 Section 18.46 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.46 In camera and protective orders. (a) Privileges. Upon... arrangements may include obtaining security clearances or giving counsel for a party access to...

  14. 28 CFR 68.42 - In camera and protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false In camera and protective orders. 68.42... In camera and protective orders. (a) Privileged communications. Upon application of any person, the.... Such arrangements may include obtaining security clearances or giving counsel for a party access...

  15. 29 CFR 18.46 - In camera and protective orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true In camera and protective orders. 18.46 Section 18.46 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.46 In camera and protective orders. (a) Privileges. Upon... arrangements may include obtaining security clearances or giving counsel for a party access to...

  16. 29 CFR 18.46 - In camera and protective orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false In camera and protective orders. 18.46 Section 18.46 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.46 In camera and protective orders. (a) Privileges. Upon... arrangements may include obtaining security clearances or giving counsel for a party access to...

  17. 28 CFR 68.42 - In camera and protective orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false In camera and protective orders. 68.42... In camera and protective orders. (a) Privileged communications. Upon application of any person, the.... Such arrangements may include obtaining security clearances or giving counsel for a party access...

  18. 28 CFR 68.42 - In camera and protective orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false In camera and protective orders. 68.42... In camera and protective orders. (a) Privileged communications. Upon application of any person, the.... Such arrangements may include obtaining security clearances or giving counsel for a party access...

  19. 29 CFR 18.46 - In camera and protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true In camera and protective orders. 18.46 Section 18.46 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.46 In camera and protective orders. (a) Privileges. Upon... arrangements may include obtaining security clearances or giving counsel for a party access to...

  20. 29 CFR 18.46 - In camera and protective orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false In camera and protective orders. 18.46 Section 18.46 Labor... OFFICE OF ADMINISTRATIVE LAW JUDGES General § 18.46 In camera and protective orders. (a) Privileges. Upon... arrangements may include obtaining security clearances or giving counsel for a party access to...

  1. 28 CFR 68.42 - In camera and protective orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false In camera and protective orders. 68.42... In camera and protective orders. (a) Privileged communications. Upon application of any person, the.... Such arrangements may include obtaining security clearances or giving counsel for a party access...

  2. 19 CFR 206.66 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... business information under administrative protective order. 206.66 Section 206.66 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL... certain confidential business information under administrative protective order. In an investigation...

  3. 6 CFR 13.24 - Protective order.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Protective order. 13.24 Section 13.24 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.24 Protective order. (a) A party or a prospective witness or deponent may file a motion for a protective...

  4. 6 CFR 13.24 - Protective order.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Protective order. 13.24 Section 13.24 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.24 Protective order. (a) A party or a prospective witness or deponent may file a motion for a protective...

  5. 40 CFR 27.24 - Protective order.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Protective order. 27.24 Section 27.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROGRAM FRAUD CIVIL REMEDIES § 27.24... confidential research, development, or commercial information, or facts pertaining to any...

  6. 40 CFR 27.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Protective order. 27.24 Section 27.24 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROGRAM FRAUD CIVIL REMEDIES § 27.24... confidential research, development, or commercial information, or facts pertaining to any...

  7. 29 CFR 500.262 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... LABOR REGULATIONS MIGRANT AND SEASONAL AGRICULTURAL WORKER PROTECTION Administrative Proceedings Post-Hearing Procedures § 500.262 Decision and order of Administrative Law Judge. (a) The Administrative Law... 29 Labor 3 2010-07-01 2010-07-01 false Decision and order of Administrative Law Judge....

  8. 33 CFR 20.606 - Protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Protective orders. 20.606 Section 20.606 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF... in camera. The ALJ shall record any proceedings in camera. If he or she enters a protective order,...

  9. 33 CFR 20.606 - Protective orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Protective orders. 20.606 Section 20.606 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF... in camera. The ALJ shall record any proceedings in camera. If he or she enters a protective order,...

  10. 33 CFR 20.606 - Protective orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Protective orders. 20.606 Section 20.606 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF... in camera. The ALJ shall record any proceedings in camera. If he or she enters a protective order,...

  11. 33 CFR 20.606 - Protective orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Protective orders. 20.606 Section 20.606 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF... in camera. The ALJ shall record any proceedings in camera. If he or she enters a protective order,...

  12. 33 CFR 20.606 - Protective orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Protective orders. 20.606 Section 20.606 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY GENERAL RULES OF... in camera. The ALJ shall record any proceedings in camera. If he or she enters a protective order,...

  13. 38 CFR 42.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.24 Protective order. (a) A party or a prospective witness or deponent may file a motion for a protective order with respect to discovery sought by an... more of the following: (1) That the discovery not be had; (2) That the discovery may be had only...

  14. 14 CFR 1264.123 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PENALTIES ACT OF 1986 § 1264.123 Protective order. (a) A party or a prospective witness or deponent may file a motion for a protective order with respect to discovery sought by an opposing party or with... the following: (1) That the discovery not be had; (2) That the discovery may be had only on...

  15. 31 CFR 16.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FRAUD CIVIL REMEDIES ACT OF 1986 § 16.24 Protective order. (a) A party or a prospective witness or deponent may file a motion for a protective order with respect to discovery sought by an opposing party or... following: (1) That the discovery not be had; (2) That the discovery may be had only on specified terms...

  16. 34 CFR 33.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Protective order. 33.24 Section 33.24 Education Office of the Secretary, Department of Education PROGRAM FRAUD CIVIL REMEDIES ACT § 33.24 Protective order.... (3) That the discovery may be had only through a method of discovery other than that requested....

  17. 12 CFR 308.523 - Protective order.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Protective order. 308.523 Section 308.523 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.523 Protective order. (a) A party or...

  18. 12 CFR 308.523 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Protective order. 308.523 Section 308.523 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.523 Protective order. (a) A party or...

  19. 12 CFR 308.523 - Protective order.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Protective order. 308.523 Section 308.523 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.523 Protective order. (a) A party or...

  20. 12 CFR 308.523 - Protective order.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Protective order. 308.523 Section 308.523 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.523 Protective order. (a) A party or...

  1. 12 CFR 308.523 - Protective order.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Protective order. 308.523 Section 308.523 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE RULES OF PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.523 Protective order. (a) A party or...

  2. 24 CFR 26.44 - Protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HEARING PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.44 Protective... respect to discovery sought by an opposing party or with respect to the hearing, seeking to limit the..., or undue burden or expense because: (1) The discovery sought is unreasonably cumulative...

  3. 40 CFR 29.4 - What are the Administrator's general responsibilities under the Order?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false What are the Administrator's general responsibilities under the Order? 29.4 Section 29.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.4...

  4. 40 CFR 29.4 - What are the Administrator's general responsibilities under the Order?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false What are the Administrator's general responsibilities under the Order? 29.4 Section 29.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.4...

  5. 40 CFR 29.4 - What are the Administrator's general responsibilities under the Order?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false What are the Administrator's general responsibilities under the Order? 29.4 Section 29.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.4...

  6. 40 CFR 29.4 - What are the Administrator's general responsibilities under the Order?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false What are the Administrator's general responsibilities under the Order? 29.4 Section 29.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.4...

  7. 40 CFR 29.4 - What are the Administrator's general responsibilities under the Order?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false What are the Administrator's general responsibilities under the Order? 29.4 Section 29.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL INTERGOVERNMENTAL REVIEW OF ENVIRONMENTAL PROTECTION AGENCY PROGRAMS AND ACTIVITIES § 29.4...

  8. 24 CFR 180.535 - Protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... order, to make all or part of the showing of good cause in camera. If such a showing is made, upon motion of the party or other person from whom discovery is sought, an in camera record of the proceedings may be made. If the ALJ enters a protective order, any in camera record of such showing shall...

  9. 15 CFR Supplement No. 2 to Part 736 - Administrative Orders

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Administrative Orders No. Supplement No. 2 to Part 736 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... PROHIBITIONS Pt. 736, Supp. 2 Supplement No. 2 to Part 736—Administrative Orders Administrative Order...

  10. 15 CFR Supplement No. 2 to Part 736 - Administrative Orders

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Administrative Orders No. Supplement No. 2 to Part 736 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... PROHIBITIONS Pt. 736, Supp. 2 Supplement No. 2 to Part 736—Administrative Orders Administrative Order...

  11. 15 CFR Supplement No. 2 to Part 736 - Administrative Orders

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Administrative Orders No. Supplement No. 2 to Part 736 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... PROHIBITIONS Pt. 736, Supp. 2 Supplement No. 2 to Part 736—Administrative Orders Administrative Order...

  12. 15 CFR Supplement No. 2 to Part 736 - Administrative Orders

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Administrative Orders No. Supplement No. 2 to Part 736 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... PROHIBITIONS Pt. 736, Supp. 2 Supplement No. 2 to Part 736—Administrative Orders Administrative Order...

  13. 15 CFR Supplement No. 2 to Part 736 - Administrative Orders

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Administrative Orders No. Supplement No. 2 to Part 736 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... PROHIBITIONS Pt. 736, Supp. 2 Supplement No. 2 to Part 736—Administrative Orders Administrative Order...

  14. 28 CFR 71.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FRAUD CIVIL REMEDIES ACT OF 1986 Implementation for Actions Initiated by the Department of Justice § 71... protective order with respect to discovery sought by an opposing party or with respect to the hearing..., oppression, or undue burden or expense, including one or more of the following: (1) That the discovery not...

  15. 22 CFR 224.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224... protective order with respect to discovery sought by an opposing party or, with respect to the hearing..., oppression, or undue burden or expense, including one or more of the following: (1) That the discovery not...

  16. 7 CFR 1126.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1126.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE SOUTHWEST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  17. 7 CFR 1005.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1005.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE APPALACHIAN MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  18. 7 CFR 1032.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1032.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE CENTRAL MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  19. 7 CFR 1007.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1007.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE SOUTHEAST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  20. 7 CFR 1131.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1131.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE ARIZONA MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  1. 7 CFR 1006.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1006.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE FLORIDA MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  2. 7 CFR 1001.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1001.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE NORTHEAST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  3. 7 CFR 1000.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1000.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE GENERAL PROVISIONS OF FEDERAL MILK MARKETING ORDERS Administrative Assessment and Marketing Service Deduction § 1000.85...

  4. 7 CFR 1124.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1124.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE PACIFIC NORTHWEST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  5. 7 CFR 1030.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1030.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE UPPER MIDWEST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  6. 7 CFR 1033.85 - Assessment for order administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1033.85 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Milk), DEPARTMENT OF AGRICULTURE MILK IN THE MIDEAST MARKETING AREA Order Regulating Handling Administrative Assessment and Marketing Service Deduction §...

  7. 29 CFR 801.67 - Decision and Order of Administrative Law Judge.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Decision and Order of Administrative Law Judge. 801.67 Section 801.67 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative...

  8. 29 CFR 801.67 - Decision and Order of Administrative Law Judge.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Decision and Order of Administrative Law Judge. 801.67 Section 801.67 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative...

  9. 29 CFR 801.67 - Decision and Order of Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Decision and Order of Administrative Law Judge. 801.67 Section 801.67 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative...

  10. 29 CFR 801.67 - Decision and Order of Administrative Law Judge.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Decision and Order of Administrative Law Judge. 801.67 Section 801.67 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative...

  11. 29 CFR 801.67 - Decision and Order of Administrative Law Judge.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Decision and Order of Administrative Law Judge. 801.67 Section 801.67 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative...

  12. 15 CFR 764.6 - Protective administrative measures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Protective administrative measures. 764.6 Section 764.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... ENFORCEMENT AND PROTECTIVE MEASURES § 764.6 Protective administrative measures. (a) License...

  13. 15 CFR 764.6 - Protective administrative measures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Protective administrative measures. 764.6 Section 764.6 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade... ENFORCEMENT AND PROTECTIVE MEASURES § 764.6 Protective administrative measures. (a) License...

  14. 49 CFR 386.39 - Protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS RULES OF PRACTICE FOR MOTOR... judge; or (f) A trade secret or other confidential research, development, or commercial information...

  15. 12 CFR Appendix A to Subpart C of... - Model Stipulation for Protective Order and Model Protective Order

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Model Stipulation for Protective Order and Model Protective Order A Appendix A to Subpart C of Part 4 Banks and Banking COMPTROLLER OF THE CURRENCY... Pt. 4, Subpt. C, App. A Appendix A to Subpart C of Part 4—Model Stipulation for Protective Order...

  16. 12 CFR Appendix A to Subpart C of... - Model Stipulation for Protective Order and Model Protective Order

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Model Stipulation for Protective Order and Model Protective Order A Appendix A to Subpart C of Part 4 Banks and Banking COMPTROLLER OF THE CURRENCY... Pt. 4, Subpt. C, App. A Appendix A to Subpart C of Part 4—Model Stipulation for Protective Order...

  17. 12 CFR Appendix A to Subpart C of... - Model Stipulation for Protective Order and Model Protective Order

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Model Stipulation for Protective Order and Model Protective Order A Appendix A to Subpart C of Part 4 Banks and Banking COMPTROLLER OF THE CURRENCY... Pt. 4, Subpt. C, App. A Appendix A to Subpart C of Part 4—Model Stipulation for Protective Order...

  18. 4 CFR 21.4 - Protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... material, as well as other information the release of which could result in a competitive advantage to one... the applicant is not involved in competitive decision-making for any firm that could gain a competitive advantage from access to the protected information and that there will be no significant risk...

  19. 14 CFR 17.9 - Protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... a competitive advantage to one or more firms. (b) The terms of the Office of Dispute Resolution for... application shall establish that the applicant is not involved in competitive decisionmaking for any firm that could gain a competitive advantage from access to the protected information and that the applicant...

  20. 41 CFR 105-70.024 - Protective order.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services... justice requires to protect a party or person from annoyance, embarrassment, oppression, or undue burden..., commercial information, or facts pertaining to any criminal investigation, proceeding, or...

  1. 41 CFR 105-70.024 - Protective order.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services... justice requires to protect a party or person from annoyance, embarrassment, oppression, or undue burden..., commercial information, or facts pertaining to any criminal investigation, proceeding, or...

  2. 25 CFR 11.1208 - Service of the protection order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Service of the protection order. 11.1208 Section 11.1208 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1208 Service of...

  3. 25 CFR 11.1208 - Service of the protection order.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Service of the protection order. 11.1208 Section 11.1208 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1208 Service of...

  4. 25 CFR 11.1208 - Service of the protection order.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Service of the protection order. 11.1208 Section 11.1208 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1208 Service of...

  5. 25 CFR 11.1208 - Service of the protection order.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Service of the protection order. 11.1208 Section 11.1208 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1208 Service of...

  6. 25 CFR 11.1208 - Service of the protection order.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Service of the protection order. 11.1208 Section 11.1208 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1208 Service of...

  7. 37 CFR 404.12 - Protection and administration of inventions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of inventions. 404.12 Section 404.12 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR TECHNOLOGY POLICY, DEPARTMENT OF COMMERCE LICENSING OF GOVERNMENT OWNED INVENTIONS § 404.12 Protection and administration of inventions. A Federal agency may take any suitable and necessary steps to protect...

  8. 37 CFR 404.12 - Protection and administration of inventions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of inventions. 404.12 Section 404.12 Patents, Trademarks, and Copyrights ASSISTANT SECRETARY FOR TECHNOLOGY POLICY, DEPARTMENT OF COMMERCE LICENSING OF GOVERNMENT OWNED INVENTIONS § 404.12 Protection and administration of inventions. A Federal agency may take any suitable and necessary steps to protect...

  9. 24 CFR 180.640 - In camera and protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false In camera and protective orders. 180.640 Section 180.640 Housing and Urban Development Regulations Relating to Housing and Urban... at Hearing § 180.640 In camera and protective orders. The ALJ may limit discovery or the...

  10. 4 CFR 28.42 - Discovery procedures and protective orders.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 4 Accounts 1 2012-01-01 2012-01-01 false Discovery procedures and protective orders. 28.42 Section 28.42 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE... ACCOUNTABILITY OFFICE Procedures Discovery § 28.42 Discovery procedures and protective orders. (a) Discovery...

  11. 4 CFR 28.42 - Discovery procedures and protective orders.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 4 Accounts 1 2011-01-01 2011-01-01 false Discovery procedures and protective orders. 28.42 Section 28.42 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE... ACCOUNTABILITY OFFICE Procedures Discovery § 28.42 Discovery procedures and protective orders. (a) Discovery...

  12. 4 CFR 28.42 - Discovery procedures and protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Discovery procedures and protective orders. 28.42 Section 28.42 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE... ACCOUNTABILITY OFFICE Procedures Discovery § 28.42 Discovery procedures and protective orders. (a) Discovery...

  13. Protection Orders Protect against Assault and Injury: A Longitudinal Study of Police-Involved Women Victims of Intimate Partner Violence

    ERIC Educational Resources Information Center

    Kothari, Catherine L.; Rhodes, Karin V.; Wiley, James A.; Fink, Jeffrey; Overholt, Scott; Dichter, Melissa E.; Marcus, Steven C.; Cerulli, Catherine

    2012-01-01

    The objective of this study was to measure the efficacy of protection orders (POs) in reducing assault and injury-related outcomes using a matched comparison group and tracking outcomes over time. This study was a retrospective review of police, emergency department, family court, and prosecutor administrative records for a cohort of…

  14. 12 CFR Appendix A to Subpart C of... - Model Stipulation for Protective Order and Model Protective Order

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Model Stipulation for Protective Order and Model Protective Order A Appendix A to Subpart C of Part 4 Banks and Banking COMPTROLLER OF THE CURRENCY... Ratios for an Individual Bank Pt. 4, Subpt. C, App. A Appendix A to Subpart C of Part 4—Model...

  15. 19 CFR 206.17 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Investigations Relating to Global Safeguard Actions § 206.17 Limited disclosure of certain confidential business... business information under administrative protective order. 206.17 Section 206.17 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  16. 19 CFR 206.47 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... business information under administrative protective order. 206.47 Section 206.47 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO GLOBAL... Investigations for Relief From Market Disruption § 206.47 Limited disclosure of certain confidential...

  17. 19 CFR 206.47 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Limited disclosure of certain confidential business information under administrative protective order. 206.47 Section 206.47 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  18. 19 CFR 206.37 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Limited disclosure of certain confidential business information under administrative protective order. 206.37 Section 206.37 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  19. 19 CFR 206.66 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Limited disclosure of certain confidential business information under administrative protective order. 206.66 Section 206.66 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  20. 19 CFR 206.37 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 3 2013-04-01 2013-04-01 false Limited disclosure of certain confidential business information under administrative protective order. 206.37 Section 206.37 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  1. 19 CFR 206.47 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Limited disclosure of certain confidential business information under administrative protective order. 206.47 Section 206.47 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  2. 19 CFR 206.66 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 3 2011-04-01 2011-04-01 false Limited disclosure of certain confidential business information under administrative protective order. 206.66 Section 206.66 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  3. 19 CFR 206.47 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Limited disclosure of certain confidential business information under administrative protective order. 206.47 Section 206.47 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  4. 19 CFR 206.66 - Limited disclosure of certain confidential business information under administrative protective...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 3 2014-04-01 2014-04-01 false Limited disclosure of certain confidential business information under administrative protective order. 206.66 Section 206.66 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION NONADJUDICATIVE INVESTIGATIONS INVESTIGATIONS RELATING TO...

  5. Outcomes of Civil Protective Orders: Results from One State

    ERIC Educational Resources Information Center

    Diviney, Charles L.; Parekh, Asha; Olson, Lenora M.

    2009-01-01

    This study compares final sentencing decisions ordered by judges to federal and state sentencing guidelines for protective order violations. The authors reviewed violations that were pled before the largest district court in Utah and found that in the majority of cases, defendants were not sentenced in accordance with federal and state guidelines.…

  6. 32 CFR 635.29 - Domestic violence and protection orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 4 2014-07-01 2013-07-01 true Domestic violence and protection orders. 635.29... ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Offense Reporting § 635.29 Domestic violence... permitted by law and regulation. AR 608-18 contains additional information about domestic violence...

  7. 32 CFR 635.29 - Domestic violence and protection orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Domestic violence and protection orders. 635.29... ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Offense Reporting § 635.29 Domestic violence... permitted by law and regulation. AR 608-18 contains additional information about domestic violence...

  8. 32 CFR 635.29 - Domestic violence and protection orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 4 2013-07-01 2013-07-01 false Domestic violence and protection orders. 635.29... ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Offense Reporting § 635.29 Domestic violence... permitted by law and regulation. AR 608-18 contains additional information about domestic violence...

  9. 32 CFR 635.29 - Domestic violence and protection orders.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Domestic violence and protection orders. 635.29... ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Offense Reporting § 635.29 Domestic violence... permitted by law and regulation. AR 608-18 contains additional information about domestic violence...

  10. 32 CFR 635.29 - Domestic violence and protection orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 4 2012-07-01 2011-07-01 true Domestic violence and protection orders. 635.29... ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Offense Reporting § 635.29 Domestic violence... permitted by law and regulation. AR 608-18 contains additional information about domestic violence...

  11. 17 CFR 201.322 - Evidence: Confidential information, protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Evidence: Confidential information, protective orders. 201.322 Section 201.322 Commodity and Securities Exchanges SECURITIES AND... documents are unavailable, the movant shall file for in camera inspection a sealed copy of the documents...

  12. 17 CFR 201.322 - Evidence: Confidential information, protective orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Evidence: Confidential information, protective orders. 201.322 Section 201.322 Commodity and Securities Exchanges SECURITIES AND... documents are unavailable, the movant shall file for in camera inspection a sealed copy of the documents...

  13. 17 CFR 201.322 - Evidence: Confidential information, protective orders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Evidence: Confidential information, protective orders. 201.322 Section 201.322 Commodity and Securities Exchanges SECURITIES AND... documents are unavailable, the movant shall file for in camera inspection a sealed copy of the documents...

  14. 17 CFR 201.322 - Evidence: Confidential information, protective orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Evidence: Confidential information, protective orders. 201.322 Section 201.322 Commodity and Securities Exchanges SECURITIES AND... documents are unavailable, the movant shall file for in camera inspection a sealed copy of the documents...

  15. 17 CFR 201.322 - Evidence: Confidential information, protective orders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Evidence: Confidential information, protective orders. 201.322 Section 201.322 Commodity and Securities Exchanges SECURITIES AND... documents are unavailable, the movant shall file for in camera inspection a sealed copy of the documents...

  16. 17 CFR 242.611 - Order protection rule.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Order protection rule. 242.611 Section 242.611 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) REGULATIONS M, SHO, ATS, AC, AND NMS AND CUSTOMER MARGIN REQUIREMENTS FOR SECURITY FUTURES Regulation...

  17. Civil Protective Order Outcomes: Violations and Perceptions of Effectiveness

    ERIC Educational Resources Information Center

    Logan, T. K.; Walker, Robert

    2009-01-01

    This study examined protective order (PO) outcomes for a period of 12 months for 698 women from multiple jurisdictions. Overall, results indicate that 2 out of 5 women did not experience violence after the PO was issued; however, 3 out of 5 women did experience ongoing violence. Two key risk factors were associated with PO violations and are…

  18. 45 CFR 681.22 - Are protective orders available?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Are protective orders available? 681.22 Section 681.22 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... confidential research, development, commercial information, or facts pertaining to any criminal...

  19. Layered virus protection for the operations and administrative messaging system

    NASA Technical Reports Server (NTRS)

    Cortez, R. H.

    2002-01-01

    NASA's Deep Space Network (DSN) is critical in supporting the wide variety of operating and plannedunmanned flight projects. For day-to-day operations it relies on email communication between the three Deep Space Communication Complexes (Canberra, Goldstone, Madrid) and NASA's Jet Propulsion Laboratory. The Operations & Administrative Messaging system, based on the Microsoft Windows NTand Exchange platform, provides the infrastructure that is required for reliable, mission-critical messaging. The reliability of this system, however, is threatened by the proliferation of email viruses that continue to spread at alarming rates. A layered approach to email security has been implemented across the DSN to protect against this threat.

  20. 28 CFR 68.52 - Final order of the Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Final order of the Administrative Law Judge. 68.52 Section 68.52 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE... Administrative Law Judge may allow, the Administrative Law Judge may require the parties to file...

  1. 77 FR 52322 - McClellan Air Force Base Superfund Site Proposed Notice of Administrative Order on Consent

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY McClellan Air Force Base Superfund Site Proposed Notice of Administrative Order on Consent AGENCY... Base Superfund Site (``Site'') in McClellan, California has been negotiated by the Agency and...

  2. Review of orders and regulations requiring environmental protection

    SciTech Connect

    Kelly, E.; Cunningham, R.; Michael, D.

    1996-09-01

    With the increased awareness of and interest in potential ecological risks associated with past, current, and future Department of Energy (DOE) activities, DOE`s Defense Programs (DP) Office of Technical and Environmental Support sponsored a study to (1) evaluate the effectiveness of the current compliance-driven environmental protection and assessment efforts relative to ecological concerns; (2) explore the need for a more focused, integrated approach to address ecological impacts; and (3) identify the requirements for an integrated approach. The study explored four questions. (a) Which federal regulations and DOE orders either explicitly require ecological assessments or implicitly require them through environmental protection language? (b) What currently is being done at selected DOE facilities to implement these regulations and orders? (c) What are private sector industries doing in terms of ecological risk assessments and how do industry approaches and issues compare with those of DOE? (d) What, if anything, in addition to current efforts is needed to ensure the protection of ecological resources associated with DOE facilities, to support defensible decision making, and to improve efficiency? The results of this study are presented in a report titled {open_quotes}Integrated, Comprehensive Ecological Impact Assessments In Support of Department of Energy Decision Making{close_quotes}. This report is a companion document to that report. This report provides a more detailed discussion of the document reviews of the relevant environmental protection regulations and current and pending DOE orders. The main goal of the document reviews was to understand existing requirements for ecological data collection and impact assessments.

  3. Protection Orders Protect Against Assault and Injury: A Longitudinal Study of Police-Involved Women Victims of Intimate Partner Violence

    PubMed Central

    Kothari, Catherine L.; Rhodes, Karin V.; Wiley, James A.; Fink, Jeffrey; Overholt, Scott; Dichter, Melissa E.; Marcus, Steven C.; Cerulli, Catherine

    2014-01-01

    Objective To measure the efficacy of protection orders (POs) in reducing assault and injury-related outcomes using a matched comparison group and tracking outcomes over time. Methods This study was a retrospective review of police, emergency department, family court and prosecutor administrative records for a cohort of police-involved female IPV victims; all events over a four-year study period were abstracted. Victims who obtained protection orders (POs) were compared to a propensity-score-based match group without POs over three time periods: Before, during, and after the issuance of a PO. Results Having a PO in place was associated with significantly more calls to police for non-assaultive incidents, and more police charging requests that were multiple-count and felony-level. Comparing outcomes, PO victims had police incident rates that were more than double the matched group prior to the PO, but dropped to the level of the matched group during and after the order. ED visits dropped over time for both groups. Conclusion This study confirmed the protective effect of POs, which are associated with reduced police incidents and emergency department visits both during and after the order, and reduced police incidents compared to a matched comparison group. PMID:22491224

  4. Symmetry-protected topologically ordered states for universal quantum computation

    NASA Astrophysics Data System (ADS)

    Poulsen Nautrup, Hendrik; Wei, Tzu-Chieh

    Measurement-based quantum computation (MBQC) is a model for quantum information processing utilizing only local measurements on suitably entangled resource states for the implementation of quantum gates. A complete characterization for universal resource states is still missing. It has been shown that symmetry-protected topological order (SPTO) in one dimension can be exploited for the protection of certain quantum gates in MBQC. Here we investigate whether any 2D nontrivial SPTO states can serve as resource for MBQC. In particular, we show that the nontrivial SPTO ground state of the CZX model on the square lattice by Chen et al. [Phys. Rev. B 84, 235141 (2011)] can be reduced to a 2D cluster state by local measurement, hence a universal resource state. Such ground states have been generalized to qudits with symmetry action described by three cocycles of a finite group G of order d and shown to exhibit nontrivial SPTO. We also extend these to arbitary lattices and show that the generalized two-dimensional plaquette states on arbitrary lattices exhibit nontrivial SPTO in terms of symmetry fractionalization and that they are universal resource states for quantum computation. SPTO states therefore can provide a new playground for measurement-based quantum computation. This work was supported in part by the National Science Foundation.

  5. Levosimendan Administration in Limb Ischemia: Multicomponent Signaling Serving Kidney Protection

    PubMed Central

    Onody, Peter; Aranyi, Peter; Turoczi, Zsolt; Stangl, Rita; Fulop, Andras; Dudas, Emese; Lotz, Gabor; Szijarto, Attila

    2016-01-01

    Aims and Objectives Acute renal failure is a severe complication of lower extremity major arterial reconstructions, which could even be fatal. Levosimendan is a dual-acting positive inotropic and vasodilatory agent, which is suspected to have protective effects against cardiac ischemia. However, there is no data available on lower limb or remote organ ischemic injuries therefore the aim of the study was to investigate the effect of levosimendan on lower limb ischemia-reperfusion injury and the corollary renal dysfunction. Methods Male Wistar rats underwent 180 min bilateral lower limb ischemia followed by 4 or 24 hours of reperfusion. Intravenous Levosimendan was administered continuously (0.2μg/bwkg/min) throughout the whole course of ischemia and the first 3h of reperfusion. Results were compared with sham-operated and ischemia-reperfusion groups. Hemodynamic monitoring was performed by invasive arterial blood pressure measurement. Kidney and lower limb muscle microcirculation was registered by a laser Doppler flowmeter. After 4h and 24h of reperfusion, serum, urine and histological samples were collected. Results Systemic hemodynamic parameters and microcirculation of kidney and the lower limb significantly improved in the Levosimendan treated group. Muscle viability was significantly preserved 4 and 24 hours after reperfusion. At the same time, renal functional laboratory tests and kidney histology demonstrated significantly less expressive kidney injury in Levosimendan groups. TNF-α levels were significantly less elevated in the Levosimendan group 4 hours after reperfusion. Conclusion The results claim a protective role for Levosimendan administration during major vascular surgeries to prevent renal complications. PMID:27684548

  6. 20 CFR 422.440 - What are your employer's responsibilities under an administrative wage garnishment order?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false What are your employer's responsibilities under an administrative wage garnishment order? 422.440 Section 422.440 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Collection of Debts by Administrative Wage Garnishment § 422.440 What are your...

  7. 20 CFR 422.440 - What are your employer's responsibilities under an administrative wage garnishment order?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What are your employer's responsibilities under an administrative wage garnishment order? 422.440 Section 422.440 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Collection of Debts by Administrative Wage...

  8. Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy.

    PubMed

    Chen, Yung-Lung; Chung, Sheng-Ying; Chai, Han-Tan; Chen, Chih-Hung; Liu, Chu-Feng; Chen, Yi-Ling; Huang, Tien-Hung; Zhen, Yen-Yi; Sung, Pei-Hsun; Sun, Cheuk-Kwan; Chua, Sarah; Lu, Hung-I; Lee, Fan-Yen; Sheu, Jiunn-Jye; Yip, Hon-Kan

    2015-12-01

    This study tested for the benefits of early administration of carvedilol as protection against doxorubicin (DOX)-induced cardiomyopathy. Thirty male, adult B6 mice were categorized into group 1 (untreated control), group 2 [DOX treatment (15 mg/every other day for 2 weeks, i.p.], and group 3 [carvedilol (15 mg/kg/d, from day 7 after DOX treatment for 28 days)], and euthanized by day 35 after DOX treatment. By day 35, the left ventricular ejection fraction (LVEF) was significantly lower in group 2 than in groups 1 and 3, and significantly lower in group 3 than in group 1, whereas the left ventricular (LV) end-diastolic and LV end-systolic dimensions showed an opposite pattern to the LVEF among the three groups. The protein expressions of fibrotic (Smad3, TGF-β), apoptotic (BAX, cleaved caspase 3, PARP), DNA damage (γ-H2AX), oxidative stress (oxidized protein), mitochondrial damage (cytosolic cytochrome-C), heart failure (brain natriuretic peptide), and hypertrophic (β-MHC) biomarkers of the LV myocardium showed an opposite pattern to the LVEF among the three groups. The protein expressions of antifibrotic (BMP-2, Smad1/5), α-MHC, and phosphorylated-Akt showed an identical pattern to the LVEF among the three groups. The microscopic findings of fibrotic and collagen-deposition areas and the numbers of γ-H2AX(+) and 53BP1(+) cells in the LV myocardium exhibited an opposite pattern, whereas the numbers of endothelial cell (CD31(+), vWF(+)) markers showed an identical pattern to the LVEF among the three groups. Cardiac stem cell markers (C-kit(+) and Sca-1(+) cells) were significantly and progressively increased from group 1 to group 3. Additionally, the in vitro study showed carvedilol treatment significantly inhibited DOX-induced cardiomyoblast DNA (CD90/XRCC1(+), CD90/53BP1(+), and r-H2AX(+) cells) damage. Early carvedilol therapy protected against DOX-induced DNA damage and cardiomyopathy.

  9. Early Administration of Carvedilol Protected against Doxorubicin-Induced Cardiomyopathy.

    PubMed

    Chen, Yung-Lung; Chung, Sheng-Ying; Chai, Han-Tan; Chen, Chih-Hung; Liu, Chu-Feng; Chen, Yi-Ling; Huang, Tien-Hung; Zhen, Yen-Yi; Sung, Pei-Hsun; Sun, Cheuk-Kwan; Chua, Sarah; Lu, Hung-I; Lee, Fan-Yen; Sheu, Jiunn-Jye; Yip, Hon-Kan

    2015-12-01

    This study tested for the benefits of early administration of carvedilol as protection against doxorubicin (DOX)-induced cardiomyopathy. Thirty male, adult B6 mice were categorized into group 1 (untreated control), group 2 [DOX treatment (15 mg/every other day for 2 weeks, i.p.], and group 3 [carvedilol (15 mg/kg/d, from day 7 after DOX treatment for 28 days)], and euthanized by day 35 after DOX treatment. By day 35, the left ventricular ejection fraction (LVEF) was significantly lower in group 2 than in groups 1 and 3, and significantly lower in group 3 than in group 1, whereas the left ventricular (LV) end-diastolic and LV end-systolic dimensions showed an opposite pattern to the LVEF among the three groups. The protein expressions of fibrotic (Smad3, TGF-β), apoptotic (BAX, cleaved caspase 3, PARP), DNA damage (γ-H2AX), oxidative stress (oxidized protein), mitochondrial damage (cytosolic cytochrome-C), heart failure (brain natriuretic peptide), and hypertrophic (β-MHC) biomarkers of the LV myocardium showed an opposite pattern to the LVEF among the three groups. The protein expressions of antifibrotic (BMP-2, Smad1/5), α-MHC, and phosphorylated-Akt showed an identical pattern to the LVEF among the three groups. The microscopic findings of fibrotic and collagen-deposition areas and the numbers of γ-H2AX(+) and 53BP1(+) cells in the LV myocardium exhibited an opposite pattern, whereas the numbers of endothelial cell (CD31(+), vWF(+)) markers showed an identical pattern to the LVEF among the three groups. Cardiac stem cell markers (C-kit(+) and Sca-1(+) cells) were significantly and progressively increased from group 1 to group 3. Additionally, the in vitro study showed carvedilol treatment significantly inhibited DOX-induced cardiomyoblast DNA (CD90/XRCC1(+), CD90/53BP1(+), and r-H2AX(+) cells) damage. Early carvedilol therapy protected against DOX-induced DNA damage and cardiomyopathy. PMID:26511374

  10. Classifying gauge anomalies through symmetry-protected trivial orders and classifying gravitational anomalies through topological orders

    NASA Astrophysics Data System (ADS)

    Wen, Xiao-Gang

    2013-08-01

    In this paper, we systematically study gauge anomalies in bosonic and fermionic weak-coupling gauge theories with gauge group G (which can be continuous or discrete) in d space-time dimensions. We show a very close relation between gauge anomalies for gauge group G and symmetry-protected trivial (SPT) orders (also known as symmetry-protected topological (SPT) orders) with symmetry group G in one-higher dimension. The SPT phases are classified by group cohomology class Hd+1(G,R/Z). Through a more careful consideration, we argue that the gauge anomalies are described by the elements in Free[Hd+1(G,R/Z)]⊕Hπ˙d+1(BG,R/Z). The well known Adler-Bell-Jackiw anomalies are classified by the free part of Hd+1(G,R/Z) (denoted as Free[Hd+1(G,R/Z)]). We refer to other kinds of gauge anomalies beyond Adler-Bell-Jackiw anomalies as non-ABJ gauge anomalies, which include Witten SU(2) global gauge anomalies. We introduce a notion of π-cohomology group, Hπ˙d+1(BG,R/Z), for the classifying space BG, which is an Abelian group and include Tor[Hd+1(G,R/Z)] and topological cohomology group Hd+1(BG,R/Z) as subgroups. We argue that Hπ˙d+1(BG,R/Z) classifies the bosonic non-ABJ gauge anomalies and partially classifies fermionic non-ABJ anomalies. Using the same approach that shows gauge anomalies to be connected to SPT phases, we can also show that gravitational anomalies are connected to topological orders (i.e., patterns of long-range entanglement) in one-higher dimension.

  11. 28 CFR 541.27 - Protection case-placement in Administrative Detention status.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Protection case-placement in Administrative Detention status. 541.27 Section 541.27 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Special Housing Units §...

  12. 28 CFR 541.27 - Protection case-placement in Administrative Detention status.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Protection case-placement in Administrative Detention status. 541.27 Section 541.27 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Special Housing Units §...

  13. 28 CFR 541.27 - Protection case-placement in Administrative Detention status.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Protection case-placement in Administrative Detention status. 541.27 Section 541.27 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Special Housing Units §...

  14. 28 CFR 541.27 - Protection case-placement in Administrative Detention status.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Protection case-placement in Administrative Detention status. 541.27 Section 541.27 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Special Housing Units §...

  15. 20 CFR 726.313 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Decision and order of Administrative Law Judge. 726.313 Section 726.313 Employees' Benefits EMPLOYMENT STANDARDS ADMINISTRATION, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG BENEFITS; REQUIREMENTS...

  16. Rank-Order Distribution of Administrative Salaries Paid, 1985-86. Nineteenth Annual Report.

    ERIC Educational Resources Information Center

    Arkansas Univ., Fayetteville. Office of Institutional Research.

    Results of a survey of salaries of full-time administrators at public, doctoral-granting institutions for 1985-1986 are presented. Rank order distributions of 12-month administrative salaries are provided for 156 state universities in 49 states and 33 university systems in 27 states. Salary data for 151 universities in 47 states are also arranged…

  17. Rank-Order Distribution of Administrative Salaries Paid, 1986-87. Twentieth Annual Report.

    ERIC Educational Resources Information Center

    Arkansas Univ., Fayetteville. Office of Institutional Research.

    Results of a survey of salaries of full-time administrators at public, doctoral-granting institutions for 1986-1987 are presented. Rank order distributions of 12-month administrative salaries are provided for 151 state universities in 49 states and 29 university systems in 23 states. Salary data for 151 universities are also arranged into the nine…

  18. 29 CFR 24.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... administrative law judge issued under the Energy Reorganization Act, other than that portion of the order... privileges of employment, and compensatory damages. In cases arising under the Safe Drinking Water Act or...

  19. 4 CFR 22.25 - Protective Orders and In Camera Review [Rule 25].

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Protective Orders and In Camera Review . 22.25 Section 22... ACCOUNTABILITY OFFICE CONTRACT APPEALS BOARD § 22.25 Protective Orders and In Camera Review . (a) Protective... specified in an order of the Board. (b) In camera review. Generally, all documents and evidence provided...

  20. 77 FR 54608 - Public Land Order No. 7796; Partial Withdrawal Revocation and Transfer of Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... Administrative Jurisdiction, Kirtland Air Force Base; New Mexico AGENCY: Bureau of Land Management, Interior..., 123 Stat. 1449 (2009), it is ordered as follows: ] 1. Public Land Order No. 995 (19 FR 5443 (1954... with Kirtland Air Force Base, is hereby revoked only insofar as it affects the following described...

  1. 29 CFR 1987.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Decision and orders of the administrative law judge. 1987.109 Section 1987.109 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... OF THE FDA FOOD SAFETY MODERNIZATION ACT Litigation § 1987.109 Decision and orders of...

  2. 29 CFR 1987.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Decision and orders of the Administrative Review Board. 1987.110 Section 1987.110 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND... UNDER SECTION 402 OF THE FDA FOOD SAFETY MODERNIZATION ACT Litigation § 1987.110 Decision and orders...

  3. 78 FR 24774 - Public Land Order No. 7813; Withdrawal Modification and Transfer of Administrative Jurisdiction...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-26

    ..., it is ordered as follows: Public Land Order No. 1843 (24 FR 3729 (1959)), which withdrew 1,929.63... wildland fire suppression facility. The Bureau of Land Management will be the primary agency with... suppression facility occupies land within the U.S. Forest Service Fort Howes Administrative Site withdrawal...

  4. 25 CFR 11.1206 - Obtaining a regular (non-emergency) order of protection.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11... act of domestic violence occurred, the court may issue an order of protection. The order must meet the... committed the act of domestic violence to refrain from acts or threats of violence against the petitioner...

  5. 25 CFR 11.1210 - Duration and renewal of a regular protection order.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Duration and renewal of a regular protection order. 11.1210 Section 11.1210 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures §...

  6. 25 CFR 11.1206 - Obtaining a regular (non-emergency) order of protection.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11... act of domestic violence occurred, the court may issue an order of protection. The order must meet the... committed the act of domestic violence to refrain from acts or threats of violence against the petitioner...

  7. 25 CFR 11.1210 - Duration and renewal of a regular protection order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Duration and renewal of a regular protection order. 11.1210 Section 11.1210 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures §...

  8. 25 CFR 11.1210 - Duration and renewal of a regular protection order.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Duration and renewal of a regular protection order. 11.1210 Section 11.1210 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures §...

  9. 25 CFR 11.1206 - Obtaining a regular (non-emergency) order of protection.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11... act of domestic violence occurred, the court may issue an order of protection. The order must meet the... committed the act of domestic violence to refrain from acts or threats of violence against the petitioner...

  10. 25 CFR 11.1206 - Obtaining a regular (non-emergency) order of protection.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11... act of domestic violence occurred, the court may issue an order of protection. The order must meet the... committed the act of domestic violence to refrain from acts or threats of violence against the petitioner...

  11. 25 CFR 11.1210 - Duration and renewal of a regular protection order.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Duration and renewal of a regular protection order. 11.1210 Section 11.1210 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures §...

  12. 3 CFR 13508 - Executive Order 13508 of May 12, 2009. Chesapeake Bay Protection and Restoration

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Bay Protection and Restoration 13508 Order 13508 Presidential Documents Executive Orders Executive Order 13508 of May 12, 2009 EO 13508 Chesapeake Bay Protection and Restoration By the authority vested... scope of pollution control within the Chesapeake Bay's watershed, restoration of the Chesapeake Bay...

  13. 25 CFR 11.1206 - Obtaining a regular (non-emergency) order of protection.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11... act of domestic violence occurred, the court may issue an order of protection. The order must meet the... committed the act of domestic violence to refrain from acts or threats of violence against the petitioner...

  14. 25 CFR 11.1210 - Duration and renewal of a regular protection order.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Duration and renewal of a regular protection order. 11.1210 Section 11.1210 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAW AND ORDER COURTS OF INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures §...

  15. 36 CFR 213.3 - Protection, occupancy, use, administration, and exercise of reservations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., administration, and exercise of reservations. 213.3 Section 213.3 Parks, Forests, and Public Property FOREST... TENANT ACT BY THE FOREST SERVICE § 213.3 Protection, occupancy, use, administration, and exercise of... the rules and regulations to govern the exercise of reservations in conveyances to the United...

  16. 36 CFR 213.3 - Protection, occupancy, use, administration, and exercise of reservations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., administration, and exercise of reservations. 213.3 Section 213.3 Parks, Forests, and Public Property FOREST... TENANT ACT BY THE FOREST SERVICE § 213.3 Protection, occupancy, use, administration, and exercise of... the rules and regulations to govern the exercise of reservations in conveyances to the United...

  17. 36 CFR 213.3 - Protection, occupancy, use, administration, and exercise of reservations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., administration, and exercise of reservations. 213.3 Section 213.3 Parks, Forests, and Public Property FOREST... TENANT ACT BY THE FOREST SERVICE § 213.3 Protection, occupancy, use, administration, and exercise of... the rules and regulations to govern the exercise of reservations in conveyances to the United...

  18. 36 CFR 213.3 - Protection, occupancy, use, administration, and exercise of reservations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., administration, and exercise of reservations. 213.3 Section 213.3 Parks, Forests, and Public Property FOREST... TENANT ACT BY THE FOREST SERVICE § 213.3 Protection, occupancy, use, administration, and exercise of... the rules and regulations to govern the exercise of reservations in conveyances to the United...

  19. 36 CFR 213.3 - Protection, occupancy, use, administration, and exercise of reservations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., administration, and exercise of reservations. 213.3 Section 213.3 Parks, Forests, and Public Property FOREST... TENANT ACT BY THE FOREST SERVICE § 213.3 Protection, occupancy, use, administration, and exercise of... the rules and regulations to govern the exercise of reservations in conveyances to the United...

  20. Protecting the normal in order to better kill the cancer

    PubMed Central

    Liu, Bingya; Ezeogu, Lewis; Zellmer, Lucas; Yu, Baofa; Xu, Ningzhi; Joshua Liao, Dezhong

    2015-01-01

    Chemotherapy is the only option for oncologists when a cancer has widely spread to different body sites. However, almost all currently available chemotherapeutic drugs will eventually encounter resistance after their initial positive effect, mainly because cancer cells develop genetic alterations, collectively coined herein as mutations, to adapt to the therapy. Some patients may still respond to a second chemo drug, but few cases respond to a third one. Since it takes time for cancer cells to develop new mutations and then select those life-sustaining ones via clonal expansion, “run against time for mutations to emerge” should be a crucial principle for treatment of those currently incurable cancers. Since cancer cells constantly change to adapt to the therapy whereas normal cells are stable, it may be a better strategy to shift our focus from killing cancer cells per se to protecting normal cells from chemotherapeutic toxicity. This new strategy requires the development of new drugs that are nongenotoxic and can quickly, in just hours or days, kill cancer cells without leaving the still-alive cells with time to develop mutations, and that should have their toxicities confined to only one or few organs, so that specific protections can be developed and applied. PMID:26177855

  1. 77 FR 56639 - Bonneville Power Administration; Notice of Petition for Declaratory Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Bonneville Power Administration; Notice of Petition for Declaratory Order Take notice that on September 4, 2012, pursuant to sections 35.28(e) and 207 of the Federal...

  2. 29 CFR 1982.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OF THE 9/11 COMMISSION ACT OF 2007, AND THE FEDERAL RAILROAD SAFETY ACT, AS AMENDED BY SECTION 1521 OF THE IMPLEMENTING RECOMMENDATIONS OF THE 9/11 COMMISSION ACT OF 2007 Litigation § 1982.109 Decision... 29 Labor 9 2014-07-01 2014-07-01 false Decision and orders of the administrative law judge....

  3. 29 CFR 1982.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... IMPLEMENTING RECOMMENDATIONS OF THE 9/11 COMMISSION ACT OF 2007, AND THE FEDERAL RAILROAD SAFETY ACT, AS AMENDED BY SECTION 1521 OF THE IMPLEMENTING RECOMMENDATIONS OF THE 9/11 COMMISSION ACT OF 2007 Litigation... 29 Labor 9 2011-07-01 2011-07-01 false Decision and orders of the Administrative Review...

  4. 29 CFR 1982.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... OF THE 9/11 COMMISSION ACT OF 2007, AND THE FEDERAL RAILROAD SAFETY ACT, AS AMENDED BY SECTION 1521 OF THE IMPLEMENTING RECOMMENDATIONS OF THE 9/11 COMMISSION ACT OF 2007 Litigation § 1982.109 Decision... 29 Labor 9 2011-07-01 2011-07-01 false Decision and orders of the administrative law judge....

  5. 29 CFR 1982.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... IMPLEMENTING RECOMMENDATIONS OF THE 9/11 COMMISSION ACT OF 2007, AND THE FEDERAL RAILROAD SAFETY ACT, AS AMENDED BY SECTION 1521 OF THE IMPLEMENTING RECOMMENDATIONS OF THE 9/11 COMMISSION ACT OF 2007 Litigation... 29 Labor 9 2014-07-01 2014-07-01 false Decision and orders of the Administrative Review...

  6. 29 CFR 1982.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OF THE 9/11 COMMISSION ACT OF 2007, AND THE FEDERAL RAILROAD SAFETY ACT, AS AMENDED BY SECTION 1521 OF THE IMPLEMENTING RECOMMENDATIONS OF THE 9/11 COMMISSION ACT OF 2007 Litigation § 1982.109 Decision... 29 Labor 9 2012-07-01 2012-07-01 false Decision and orders of the administrative law judge....

  7. 29 CFR 1982.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OF THE 9/11 COMMISSION ACT OF 2007, AND THE FEDERAL RAILROAD SAFETY ACT, AS AMENDED BY SECTION 1521 OF THE IMPLEMENTING RECOMMENDATIONS OF THE 9/11 COMMISSION ACT OF 2007 Litigation § 1982.109 Decision... 29 Labor 9 2013-07-01 2013-07-01 false Decision and orders of the administrative law judge....

  8. 3 CFR 13637 - Executive Order 13637 of March 8, 2013. Administration of Reformed Export Controls

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... shall consult with the Director of the Office of Management and Budget. (k) Those under section 36(b)(1... relate to defense articles and defense services sold, leased, or transferred under the Foreign Military... Management and Budget relating to budgetary, administrative, or legislative proposals. (b) This order...

  9. Order of Conners' CPT-II Administration within a Cognitive Test Battery Influences ADHD Indices

    ERIC Educational Resources Information Center

    Erdodi, Laszlo A.; Lajiness-O'Neill, Renee; Saules, Karen K.

    2010-01-01

    Objective: To study the effect of administration sequence on Conner's continuous performance test (CPT-II) scores in clients requesting psychological assessment. It was hypothesized that when administered at the end rather than beginning of a test battery, the test scores will show higher symptom severity. If present, order effects may cause the…

  10. 20 CFR 726.313 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Decision and order of Administrative Law Judge. 726.313 Section 726.313 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG...

  11. 20 CFR 726.313 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false Decision and order of Administrative Law Judge. 726.313 Section 726.313 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG...

  12. 20 CFR 726.313 - Decision and order of Administrative Law Judge.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false Decision and order of Administrative Law Judge. 726.313 Section 726.313 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, AS AMENDED BLACK LUNG...

  13. 77 FR 52021 - Proposed CERCLA Administrative Settlement Agreement and Order on Consent for the Mercury Refining...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... AGENCY Proposed CERCLA Administrative Settlement Agreement and Order on Consent for the Mercury Refining... ``Settling Parties'') pertaining to the Mercury Refining Superfund Site (``Site'') located in the Towns of... each Settling Party to the EPA Hazardous Substance Superfund Mercury Refining Superfund Site...

  14. 78 FR 40140 - Proposed CERCLA Administrative Settlement Agreement and Order on Consent for the Mercury Refining...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... AGENCY Proposed CERCLA Administrative Settlement Agreement and Order on Consent for the Mercury Refining... between EPA and Titan Wheel Corporation of Illinois (hereafter ``Titan'') pertaining to the Mercury.... Comments should be sent to the individual identified below and should reference the Mercury...

  15. U (1 )×U (1 ) symmetry-protected topological order in Gutzwiller wave functions

    NASA Astrophysics Data System (ADS)

    Liu, Zheng-Xin; Mei, Jia-Wei; Ye, Peng; Wen, Xiao-Gang

    2014-12-01

    Gutzwiller projection is a way to construct many-body wave functions that could carry topological order or symmetry-protected topological (SPT) order. However, an important issue is to determine whether or not a given Gutzwiller-projected wave function (GWF) carries a nontrivial SPT order, and which SPT order is carried by the wave function. In this paper, we numerically study the SPT order in a spin S =1 GWF on the kagome lattice. Using the standard Monte Carlo method, we directly confirm that the GWF has (1) gapped bulk with short-range correlations, (2) a trivial topological order via a nondegenerate ground state, and zero topological entanglement entropy, (3) a nontrivial U (1 )×U (1 ) SPT order via the Hall conductances of the protecting U (1 )×U (1 ) symmetry, and (4) a symmetry-protected gapless boundary. This represents numerical evidence of continuous symmetry-protected topological order in two-dimensional bosonic lattice systems.

  16. Second-order schedules of drug self-administration in animals.

    PubMed

    Schindler, Charles W; Panlilio, Leigh V; Goldberg, Steven R

    2002-10-01

    On a second-order schedule, a subject responds according to one schedule (the unit schedule) for a brief presentation of a stimulus such as a light. Responding by the subject on this unit schedule is then reinforced according to another schedule of reinforcement. Second-order schedules of drug injection allow the study of more complex behavioral sequences than do simple schedules and may more accurately reflect the human drug-abuse situation. Much of the early work in this area used primates as subjects and focused on the behavioral variables controlling responding. It was shown that long sequences of behavior could be maintained on second-order schedules with relatively infrequent injections of drug and that the second-order, brief-stimulus presentations were critical to the acquisition and maintenance of responding. Also, the continued presentation of the brief stimulus in extinction often led to prolonged extinction behavior. These studies clearly showed that environmental stimuli greatly influence drug self-administration behavior under second-order schedules. The focus of much of the more recent work with second-order schedules has been on the evaluation of pharmacological treatments for drug addiction, both as antagonist and substitution therapies. Both types of potential therapies have shown promise in these preclinical models of addictive behavior. The recent extension of second-order self-administration studies to rats as subjects has facilitated the investigation of neural mechanisms involved in this behavior. While this use of second-order schedules is a relatively recent phenomenon, significant contributions have already been made in identifying neural mechanisms critical to second-order schedule drug self-administration. This active area of research holds great promise for delineating specific brain regions critical to different aspects of drug addiction.

  17. [Administration Order of FEC-DOC in Breast Cancer Adjuvant Chemotherapy Has an Effect on Toxicity].

    PubMed

    Miyaki, Toshiko; Tsujimura, Hideki; Nakamura, Rikiya; Okubo, Yoshiyuki; Kumagai, Kyoya; Yamamoto, Naohito

    2015-09-01

    Sequential administration of anthracycline - and taxane-based regimens has been established as standard adjuvant chemotherapy for breast cancer. In our hospital, FEC(5-FU/EPI/CPA) followed by docetaxel therapy has been used for this indication. Recently, we changed the sequence of FEC and docetaxel to reduce skin toxicities during the docetaxel phase. Since the effect of the administration order on efficacy and toxicity is not clear, we retrospectively compared the toxicities and relative dose intensity (RDI) of the administration orders. From January to December of 2012, 46 patients received FEC followed by docetaxel (AT group), while 42 patients underwent docetaxel followed by FEC during the same period in 2013(TA group). The incidence of severe hematological and major non-hematological toxicities was similar in the two groups. There was no significant difference in RDI between groups. However, grade 2 or higher hand-foot syndrome(HFS)during the docetaxel phase, which can be a reason for dose reduction or treatment termination, was more frequently observed in the AT group than in the TA group(54% vs 33%, p<0.05). Our data shows that the risk of HFS was reduced when the taxane was administered first. Interestingly, HFS significantly increased in the winter, regardless of the administration order(p<0.01).

  18. 25 CFR 11.1202 - How to petition for an order of protection.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1202 How to petition for an order of protection. A victim of domestic violence, or the parent, guardian of a victim, or... the act of domestic violence. (b) The petitioner is not required to file for annulment, separation,...

  19. 25 CFR 11.1202 - How to petition for an order of protection.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1202 How to petition for an order of protection. A victim of domestic violence, or the parent, guardian of a victim, or... the act of domestic violence. (b) The petitioner is not required to file for annulment, separation,...

  20. 25 CFR 11.1202 - How to petition for an order of protection.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1202 How to petition for an order of protection. A victim of domestic violence, or the parent, guardian of a victim, or... the act of domestic violence. (b) The petitioner is not required to file for annulment, separation,...

  1. 25 CFR 11.1202 - How to petition for an order of protection.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1202 How to petition for an order of protection. A victim of domestic violence, or the parent, guardian of a victim, or... the act of domestic violence. (b) The petitioner is not required to file for annulment, separation,...

  2. 25 CFR 11.1202 - How to petition for an order of protection.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1202 How to petition for an order of protection. A victim of domestic violence, or the parent, guardian of a victim, or... the act of domestic violence. (b) The petitioner is not required to file for annulment, separation,...

  3. 28 CFR 68.54 - Administrative review of a final order of an Administrative Law Judge in cases arising under...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... an Administrative Law Judge in cases arising under section 274A or 274C. 68.54 Section 68.54 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE ADMINISTRATIVE LAW JUDGES IN CASES INVOLVING ALLEGATIONS OF UNLAWFUL EMPLOYMENT OF ALIENS,...

  4. In vivo administration of interleukin-2 protects susceptible mice from Theiler's virus persistence.

    PubMed Central

    Larsson-Sciard, E L; Dethlefs, S; Brahic, M

    1997-01-01

    In vivo administration of interleukin-2 (IL-2)-secreting tumor cells results in complete protection against persistent infection by Theiler's murine encephalomyelitis virus (TMEV) in susceptible DBA/2 mice. The IL-2-mediated protection was found to depend on the inoculum size as well as the timing of IL-2 administration. IL-2-treated and TMEV-infected mice displayed a three- to fourfold relative increase in virus-specific cytotoxic T-lymphocyte (CTL) precursors. Thus, we postulate that the persistence of TMEV infection in susceptible mice reflects limited numbers of relevant CTL precursors and their time course of induction and activation. PMID:8985419

  5. 6 CFR 29.4 - Protected Critical Infrastructure Information Program administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Protected Critical Infrastructure Information Program administration. 29.4 Section 29.4 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE... sufficient personnel, including such detailees or assignees from other Federal national security,...

  6. Why Is Sexual Abuse Declining? A Survey of State Child Protection Administrators.

    ERIC Educational Resources Information Center

    Jones, Lisa M.; Finkelhor, David; Kopiec, Kathy

    2001-01-01

    Interviews were conducted with child protection administrators in 43 states. More than half in states with large declines of cases of substantiated sexual abuse were unaware of any discussion of the declines within their agency or state. Possible causes for decline included increased evidentiary requirements and increased caseworker caution.…

  7. Protective effects of oral administration of yeast thioredoxin against gastric mucosal injury.

    PubMed

    Taketani, Yukiko; Kinugasa, Kimihiro; Kitajima, Rie; Nishiumi, Shin; Ashida, Hitoshi; Nakamura, Hajime; Fujita, Tuyosi; Kanzaki, Ken; Masutani, Hiroshi; Yodoi, Junji

    2014-01-01

    Thioredoxin (TRX) is a redox regulating protein which has protective effects against oxidative stress-induced damage to cells and tissues. In this study, we investigated the effects of orally administered TRX derived from edible yeast, Saccharomyces cerevisiae, on gastric mucosa. First, we examined the digestibility of orally administered yeast TRX in mice, and detected yeast TRX in the stomach for 4 h after administration. Next, we investigated the mitigation of gastric mucosal injury after the oral administration of yeast TRX in water-immersion restraint stress and HCl/ethanol-induced gastric ulcer models. Furthermore, we conducted DNA microarray analysis, using the HCl/ethanol-induced model, which revealed that several groups of genes related to tissue repair were upregulated in ulcer regions in the stomachs of rats administered with yeast TRX. These results demonstrated the viability of the use of oral administrations of yeast TRX to protect the gastric mucosa. PMID:25229862

  8. 20 CFR 422.435 - What happens when we decide to send an administrative wage garnishment order to your employer?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false What happens when we decide to send an administrative wage garnishment order to your employer? 422.435 Section 422.435 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Collection of Debts by Administrative Wage Garnishment § 422.435 What happens when we decide...

  9. 25 CFR 11.1204 - Obtaining an emergency order of protection.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1204... petition clearly shows that an act of domestic violence has occurred. The order must meet the content... to have committed a family violence act and seek to hold a hearing as soon as possible. If a...

  10. 25 CFR 11.1204 - Obtaining an emergency order of protection.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1204... petition clearly shows that an act of domestic violence has occurred. The order must meet the content... to have committed a family violence act and seek to hold a hearing as soon as possible. If a...

  11. 25 CFR 11.1204 - Obtaining an emergency order of protection.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1204... petition clearly shows that an act of domestic violence has occurred. The order must meet the content... to have committed a family violence act and seek to hold a hearing as soon as possible. If a...

  12. 25 CFR 11.1204 - Obtaining an emergency order of protection.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1204... petition clearly shows that an act of domestic violence has occurred. The order must meet the content... to have committed a family violence act and seek to hold a hearing as soon as possible. If a...

  13. 25 CFR 11.1204 - Obtaining an emergency order of protection.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... to have committed a family violence act and seek to hold a hearing as soon as possible. If a hearing... INDIAN OFFENSES AND LAW AND ORDER CODE Child Protection and Domestic Violence Procedures § 11.1204... petition clearly shows that an act of domestic violence has occurred. The order must meet the...

  14. When "Enough Is Enough": Battered Women's Decision Making around Court Orders of Protection.

    ERIC Educational Resources Information Center

    Fischer, Carla; Rose, Mary

    1995-01-01

    Discusses factors involved in the decision by battered women to seek court orders of protection. Women seeking such orders confront both tangible and symbolic fears. There are powerful motivations counteracting these fears; in addition, women experience psychological benefits from a sense of gaining some measure of control in their lives. (LKS)

  15. NonSymmorphic Symmetry Protected Topological Order in Many-body Localized Systems

    NASA Astrophysics Data System (ADS)

    Ashraf, Khalid

    Many-body localized systems have many interesting physical properties such as localization protected quantum order, symmetry protected topological order, area law in entanglement spectrum etc.. Specifically, it has been shown that closed quantum system in 1D i.e. p-wave superconducting wires host localization protected topological order. In this work, we explore the interplay between non-symmorphic symmetry which protects topological order and localization due to disorder. Using a Bogoliubov-de Gennes (BdG) description of p-wave superconductors, we study the topological edge states on a 2D non-symmorphic crystal. We show that a localization protected topological order can exist at high energy in a 2D non-symmorphic crystal. The system goes between topologically trivial and non-trivial phases based on the degree of disorder and shift between the adjacent atoms in the bipartite lattice. We further explore the nature of this phase transition by calculating the entanglement spectrum of the two phases. Finally, the effect of dimensionality on the realization of these phases are discussed.

  16. Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury

    PubMed Central

    Tong, Chao; Peng, Chuan; Wang, Lianlian; Zhang, Li; Yang, Xiaotao; Xu, Ping; Li, Jinjin; Delplancke, Thibaut; Zhang, Hua; Qi, Hongbo

    2016-01-01

    Background: Oral uptake of lycopene has been shown to be beneficial for preventing myocardial ischemia-reperfusion (I/R) injury. However, the strong first-pass metabolism of lycopene influences its bioavailability and impedes its clinic application. In this study, we determined an intravenous (IV) administration dose of lycopene protects against myocardial infarction (MI) in a mouse model, and investigated the effects of acute lycopene administration on reactive oxygen species (ROS) production and related signaling pathways during myocardial I/R. Methods: In this study, we established both in vitro hypoxia/reoxygenation (H/R) cell model and in vivo regional myocardial I/R mouse model by ligating left anterior artery descending. TTC dual staining was used to assess I/R induced MI in the absence and presence of acute lycopene administration via tail vein injection. Results: Lycopene treatment (1 μM) before reoxygenation significantly reduced cardiomyocyte death induced by H/R. Intravenous administration of lycopene to achieve 1 μM concentration in circulating blood significantly suppressed MI, ROS production, and JNK phosphorylation in the cardiac tissue of mice during in vivo regional I/R. Conclusion: Elevating circulating lycopene to 1 μM via IV injection protects against myocardial I/R injury through inhibition of ROS accumulation and consequent inflammation in mice. PMID:26950150

  17. Topological and error-correcting properties for symmetry-protected topological order

    NASA Astrophysics Data System (ADS)

    Zeng, Bei; Zhou, D. L.

    2016-03-01

    We study the symmetry-protected topological (SPT) orders for bosonic systems from an information-theoretic viewpoint. We show that with a proper choice of the onsite basis, the degenerate ground-state space of SPT orders (on a manifold with boundary) is a quantum error-correcting code with macroscopic classical distance, hence is stable against any local bit-flip errors. We show that this error-correcting property of the SPT orders has a natural connection to that of the symmetry-breaking orders, whose degenerate ground-state space is a classical error-correcting code with a macroscopic distance, providing a new angle for the hidden symmetry-breaking properties in SPT orders. We further propose new types of topological entanglement entropy that probe the SPT orders hidden in their symmetric ground states, which also signal the topological phase transitions protected by symmetry. Combined with the original definition of topological entanglement entropy that probes the “intrinsic topological orders”, and the recent proposed one that probes the symmetry-breaking orders, the set of different types of topological entanglement entropy may hence distinguish topological orders, SPT orders, and symmetry-breaking orders, which may be mixed up in a single system.

  18. 46 CFR 502.227 - Exceptions to decisions or orders of dismissal of administrative law judge; replies thereto...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... administrative law judge; replies thereto; review of decisions or orders of dismissal by Commission; and judicial review. 502.227 Section 502.227 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Briefs; Requests for Findings; Decisions; Exceptions §...

  19. Ethanol Self-Administration in Mice under a Second-Order Schedule

    PubMed Central

    Lamb, Richard J.; Pinkston, Jonathan W.; Ginsburg, Brett C.

    2015-01-01

    Long Fixed-Interval (FI) schedules, particularly second-order schedules, can engender substantial responding before drug or ethanol delivery that is uninfluenced by the direct effects of the drug or ethanol. Thus, these schedules can be used to study the effects of medications upon drug- or ethanol-seeking, uninfluenced by the direct effects of the self-administered drug or ethanol. Long FI second-order schedules are frequently used in primates and occasionally in rats. Under second-order schedules, completion of one response requirement, e.g., a Fixed Ratio 10 (FR10:S), produces a brief stimulus presentation, e.g., a 1-sec 80-dB 4-kHZ tone, and this FR10:S serves as the response unit under another schedule, e.g., a FI 1800-sec. Thus, the first FR10 completed after 1800 sec would result in delivery both of the tone and of reinforcement, e.g., 10 × 0.01 mL 16% (w/v) ethanol. To examine if such schedules could be effectively used in mice, which have advantages in neurobiological and genetic studies, we trained eight C57BL/6J mice to respond under the schedule just described. This schedule maintained substantial responding. The temporal pattern of behavior was typical of an FI schedule with responding accelerating across the interval. We also examined the effects of acute and chronic administration of fluvoxamine on this responding, and these were modest. Finally, we examined responding when alcohol and/or tone deliveries were withheld, and found that extinction occurred most rapidly when both were withheld. This work demonstrates that long FI schedules of ethanol delivery may be useful in studying ethanol seeking in mice. PMID:26254963

  20. Ethanol self-administration in mice under a second-order schedule.

    PubMed

    Lamb, Richard J; Pinkston, Jonathan W; Ginsburg, Brett C

    2015-09-01

    Long Fixed-Interval (FI) schedules, particularly second-order schedules, can engender substantial responding before drug or ethanol delivery that is uninfluenced by the direct effects of the drug or ethanol. Thus, these schedules can be used to study the effects of medications upon drug- or ethanol-seeking, uninfluenced by the direct effects of the self-administered drug or ethanol. Long FI second-order schedules are frequently used in primates and occasionally in rats. Under second-order schedules, completion of one response requirement, e.g., a Fixed Ratio 10 (FR10:S), produces a brief stimulus presentation, e.g., a 1-s 80-dB 4-kHZ tone, and this FR10:S serves as the response unit under another schedule, e.g., an FI 1800-s. Thus, the first FR10 completed after 1800 s would result in delivery both of the tone and of reinforcement, e.g., 10 × 0.01 mL 16% (w/v) ethanol. To examine if such schedules could be effectively used in mice, which have advantages in neurobiological and genetic studies, we trained eight C57BL/6J mice to respond under the schedule just described. This schedule maintained substantial responding. The temporal pattern of behavior was typical of an FI schedule with responding accelerating across the interval. We also examined the effects of acute and chronic administration of fluvoxamine on this responding, and these were modest. Finally, we examined responding when alcohol and/or tone deliveries were withheld, and found that extinction occurred most rapidly when both were withheld. This work demonstrates that long FI schedules of ethanol delivery may be useful in studying ethanol seeking in mice.

  1. Protective effect of oral administration of transgenic tobacco seeds against verocytotoxic Escherichia coli strain in piglets.

    PubMed

    Rossi, Luciana; Dell'Orto, Vittorio; Vagni, Simona; Sala, Vittorio; Reggi, Serena; Baldi, Antonella

    2014-03-01

    The use of transgenic plants as delivery system for antigenic proteins is attractive for its simplicity and increases likelihood for local immune response at sites of infection. The aim of this study was to evaluate the protective effect of oral administration of tobacco seeds, expressing the FedA, the major protein of the F18 adhesive fimbriae, and B subunit of verocytotoxin, against verocytotoxin-producing E. coli (VTEC) strain in piglets. Forty-three early weaned piglets, were randomly divided into 4 experimental groups: 3 test groups and a control. Treatment groups orally received a bolus, with different dose of tobacco seeds on 0, 1, 2, 14 days post primary administration. After challenge, with 1*10(10) CFU of O138 Escherichia coli strain, piglets showed clinical scores significantly higher in the control group compared to orally immunized groups (P < 0.05) and the latter showed a faster recovery than in CG. In conclusion, oral administration of recombinant tobacco seeds expressing antigenic proteins against VTEC strains can induce a protective effect against challenger strain in piglets.

  2. Predicted impact of mass drug administration on the development of protective immunity against Schistosoma haematobium.

    PubMed

    Mitchell, Kate M; Mutapi, Francisca; Mduluza, Takafira; Midzi, Nicholas; Savill, Nicholas J; Woolhouse, Mark E J

    2014-01-01

    Previous studies suggest that protective immunity against Schistosoma haematobium is primarily stimulated by antigens from dying worms. Praziquantel treatment kills adult worms, boosting antigen exposure and protective antibody levels. Current schistosomiasis control efforts use repeated mass drug administration (MDA) of praziquantel to reduce morbidity, and may also reduce transmission. The long-term impact of MDA upon protective immunity, and subsequent effects on infection dynamics, are not known. A stochastic individual-based model describing levels of S. haematobium worm burden, egg output and protective parasite-specific antibody, which has previously been fitted to cross-sectional and short-term post-treatment egg count and antibody patterns, was used to predict dynamics of measured egg output and antibody during and after a 5-year MDA campaign. Different treatment schedules based on current World Health Organisation recommendations as well as different assumptions about reductions in transmission were investigated. We found that antibody levels were initially boosted by MDA, but declined below pre-intervention levels during or after MDA if protective immunity was short-lived. Following cessation of MDA, our models predicted that measured egg counts could sometimes overshoot pre-intervention levels, even if MDA had had no effect on transmission. With no reduction in transmission, this overshoot occurred if protective immunity was short-lived. This implies that disease burden may temporarily increase following discontinuation of treatment, even in the absence of any reduction in the overall transmission rate. If MDA was additionally assumed to reduce transmission, a larger overshoot was seen across a wide range of parameter combinations, including those with longer-lived protective immunity. MDA may reduce population levels of immunity to urogenital schistosomiasis in the long-term (3-10 years), particularly if transmission is reduced. If MDA is stopped while

  3. Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice.

    PubMed

    Uranga, Santiago; Marinova, Dessislava; Martin, Carlos; Aguilo, Nacho

    2016-01-01

    Despite global coverage of intradermal BCG vaccination, tuberculosis remains one of the most prevalent infectious diseases in the world. Preclinical data have encouraged pulmonary tuberculosis vaccines as a promising strategy to prevent pulmonary disease, which is responsible for transmission. In this work, we describe the methodology used to demonstrate in the mouse model the benefits of intranasal BCG vaccination when compared to subcutaneous. Our data revealed greater protective efficacy following intranasal BCG administration. In addition, our results indicate that pulmonary vaccination triggers a higher immune response in lungs, including Th1 and Th17 responses, as well as an increase of immunoglobulin A (IgA) concentration in respiratory airways. Our data show correlation between protective efficacy and the presence of IL17-producing cells in lungs post-Mycobacterium tuberculosis challenge, suggesting a role for this cytokine in the protective response conferred by pulmonary vaccination. Finally, we detail the global workflow we have developed to study respiratory vaccination in the mouse model, which could be extrapolated to other tuberculosis vaccines, apart from BCG, targeting the mucosal response or other pulmonary routes of administration such as the intratracheal or aerosol. PMID:27684521

  4. 75 FR 26226 - Executive Order 13508 Chesapeake Bay Protection and Restoration Section 203 Final Coordinated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... Order 13508, Chesapeake Bay Protection and Restoration, dated May 12, 2009 (74 FR 23099, May 15, 2009... released for public comment on November 9, 2009 (74 FR 57675, November 9, 2009). This final strategy... May 12, 2009 (74 FR 23099, May 15, 2009), required a Federal Leadership Committee composed of...

  5. Augmentation of protective immune responses against viral infection by oral administration of schizophyllan

    PubMed Central

    Itoh, Wataru

    1997-01-01

    An oral administration of fungal polysaccharide schizophyllan has augmented protective immune responses to Sendai virus infection in mice and the rodshaped DNA virus of Penaeus japonicus (RV-PJ) infection in Kuruma shrimps. When schizophyllan was administered orally at a dose of 50 or 100 mg/kg body weight per day, the survival rates after virus challenge were significantly higher than those of the control groups. High phagocytic activities were observed in the haemocytes of the schizophyllan-fed shrimps.These results suggest that schizophyllan confers effective protection against viral infection by increasing antiviral immune responses, and that it could be used to boost immunity to virus infection in animals or in invertebrates. PMID:18472856

  6. Constructing the symbolic complainant: police subculture and the nonenforcement of protection orders for battered women.

    PubMed

    Rigakos, G S

    1995-01-01

    This exploratory study examines the effects of patriarchy on police and individual attitudes toward the enforcement of protective court orders for battered women. Police officers (N = 13) and justice officials (N = 8) in the Municipality of Delta were interviewed for their opinions on the efficacy of both Criminal Code peace bonds and Family Relations Act (R.S.B.C., amended 1986) civil restraining orders. Interview data suggest that both protective orders are rarely treated seriously by the police or the courts. It is argued that the occupational culture of the police leads to exaggerated patriarchal notions of women, marriage, and family that are conservative; blame the victim; point finger at other institutions; foster images of women as manipulative; and produce a fictitious narrative of battered women. PMID:8777189

  7. 29 CFR 1981.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... determination to dismiss was made in error. Rather, if there otherwise is jurisdiction, the administrative law... person's former position, together with the compensation (including back pay), terms, conditions,...

  8. 29 CFR 1981.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... determination to dismiss was made in error. Rather, if there otherwise is jurisdiction, the administrative law... person's former position, together with the compensation (including back pay), terms, conditions,...

  9. Systemic Administration of Proteoglycan Protects BALB/c Retired Breeder Mice from Experimental Arthritis

    PubMed Central

    Ishikawa, Larissa Lumi Watanabe; Colavite, Priscila Maria; Fraga-Silva, Thais Fernanda de Campos; Mimura, Luiza Ayumi Nishiyama; França, Thais Graziela Donegá; Zorzella-Pezavento, Sofia Fernanda Gonçalves; Chiuso-Minicucci, Fernanda; Marcolino, Larissa Doddi; Marques, Camila; Ikoma, Maura Rosane Valerio; Sartori, Alexandrina

    2016-01-01

    This study was undertaken to evaluate the prophylactic potential of proteoglycan (PG) administration in experimental arthritis. Female BALB/c retired breeder mice received two (2xPG50 and 2xPG100 groups) or three (3xPG50 group) intraperitoneal doses of bovine PG (50 μg or 100 μg) every three days. A week later the animals were submitted to arthritis induction by immunization with three i.p. doses of bovine PG associated with dimethyldioctadecylammonium bromide adjuvant at intervals of 21 days. Disease severity was daily assessed after the third dose by score evaluation. The 3xPG50 group showed significant reduction in prevalence and clinical scores. This protective effect was associated with lower production of IFN-γ and IL-17 and increased production of IL-5 and IL-10 by spleen cells restimulated in vitro with PG. Even though previous PG administration restrained dendritic cells maturation this procedure did not alter the frequency of regulatory Foxp3+ T cells. Lower TNF-α and IL-6 levels and higher expression of ROR-γ and GATA-3 were detected in the paws of protected animals. A delayed-type hypersensitivity reaction confirmed specific tolerance induction. Taken together, these results indicate that previous PG inoculation determines a specific tolerogenic effect that is able to decrease severity of subsequently induced arthritis. PMID:27294161

  10. 29 CFR 1980.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... administrative law judge, or a named person alleging that the complaint was frivolous or brought in bad faith who... a complaint was frivolous or was brought in bad faith, the Board may award to the named person...

  11. 77 FR 76518 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... Trade Agreement (NAFTA) Article 1904.13, and safeguard-related provisions such as section 202 of the... the 24-hour rule. See 56 FR 4846 (February 6, 1991); 57 FR 12335 (April 9, 1992); 58 FR 21991 (April 26, 1993); 59 FR 16834 (April 8, 1994); 60 FR 24880 (May 10, 1995); 61 FR 21203 (May 9, 1996); 62...

  12. 76 FR 78945 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ..., section 337 of the Tariff Act of 1930, the North American Free Trade Agreement (NAFTA) Article 1904.13... FR 4846 (February 6, 1991); 57 FR 12335 (April 9, 1992); 58 FR 21991 (April 26, 1993); 59 FR 16834 (April 8, 1994); 60 FR 24880 (May 10, 1995); 61 FR 21203 (May 9, 1996); 62 FR 13164 (March 19, 1997);...

  13. 75 FR 66127 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-27

    ... of the Tariff Act of 1930, and North American Free Trade Agreement (NAFTA) Article 1904.13, 19 U.S.C... to violations of Commission APOs and the 24-hour rule. See 56 FR 4846 (February 6, 1991); 57 FR 12335 (April 9, 1992); 58 FR 21991 (April 26, 1993); 59 FR 16834 (April 8, 1994); 60 FR 24880 (May 10,...

  14. 78 FR 79481 - Summary of Commission Practice Relating to Administrative Protective Orders

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ..., section 337 of the Tariff Act of 1930, the North American Free Trade Agreement (NAFTA) Article 1904.13... actions in response to violations of Commission APOs and the 24-hour rule. See 56 FR 4846 (February 6, 1991); 57 FR 12335 (April 9, 1992); 58 FR 21991 (April 26, 1993); 59 FR 16834 (April 8, 1994); 60...

  15. 29 CFR 1978.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Act, the perception of protected activity, was a contributing factor in the adverse action alleged... or the perception thereof. (c) Neither the Assistant Secretary's determination to dismiss a...

  16. 29 CFR 1978.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Act, the perception of protected activity, was a contributing factor in the adverse action alleged... or the perception thereof. (c) Neither the Assistant Secretary's determination to dismiss a...

  17. [The protective action of tocopherol acetate in simultaneous administration with nitrobenzene and its chloro derivatives].

    PubMed

    Paranich, A V; Paranich, L I; Bugaĭ, E V; Ortis, L F

    1998-05-01

    In experiments in albino rats, effects were studied of nitrobenzene and its chloro derivatives in intragastric administration with tocoferolum acetatum. Changes in the process of lipid peroxidation in blood serum, liver, and spleen which were characteristic of xenobiotics themselves have been shown to be less pronounced in this setting. Tocoferolum acetatum being administered at the same time is actively drawn into the metabolism. Normalization of the antioxidant activity of the tissues under investigation was to be observed, with lipid peroxidation and the antioxidant system being in equilibrium. Tocoferolum acetatum administered with xenobiotics has been shown to have a protective action. Tocoferolum acetatum is recommended to be included into diets for workers engaged in chemical industry on a prophylactic basis.

  18. Chronic administration of troxerutin protects mouse brain against D-galactose-induced impairment of cholinergic system.

    PubMed

    Lu, Jun; Wu, Dong-Mei; Hu, Bin; Cheng, Wei; Zheng, Yuan-Lin; Zhang, Zi-Feng; Ye, Qin; Fan, Shao-Hua; Shan, Qun; Wang, Yong-Jian

    2010-02-01

    Previous evidence showed that administration of d-galactose (d-gal) increased ROS production and resulted in impairment of cholinergic system. Troxerutin, a natural bioflavonoid, has been reported to have many benefits and medicinal properties. In this study, we evaluated the protective effect of troxerutin against d-gal-induced impairment of cholinergic system, and explored the potential mechanism of its action. Our results displayed that troxerutin administration significantly improved behavioral performance of d-gal-treated mice in step-through test and morris water maze task. One of the potential mechanisms of this action was decreased AGEs, ROS and protein carbonyl levels in the basal forebrain, hippocampus and front cortex of d-gal-treated mice. Furthermore, our results also showed that troxerutin significantly inhibited cholinesterase (AchE) activity, increased the expression of nicotinic acetylcholine receptor alpha 7 (nAchRalpha7) and enhanced interactions between nAchRalpha7 and either postsynaptic density protein 95 (PSD95) or N-methyl-d-aspartate receptors subunit 1 (NMDAR1) in the basal forebrain, hippocampus and front cortex of d-gal-treated mice, which could help restore impairment of brain function.

  19. Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage

    PubMed Central

    Kano, Mitsuyoshi; Kubota, Norihiro; Masuoka, Norie; Hori, Tetsuji; Miyazaki, Kouji; Ishikawa, Fumiyasu

    2016-01-01

    The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of isoflavones. The erythema intensity of dorsal skin was significantly higher in ovariectomized mice than in sham-operated mice (p < 0.05). The erythema intensity and epidermal thickness of dorsal skin were significantly lower in the fermented soymilk diet group than in the control diet group (each p < 0.05). Levels of cyclobutane pyrimidine dimers in dorsal skin were significantly lower in the fermented soymilk diet group than in the control group (p < 0.05). Serum and dorsal skin isoflavone concentrations were significantly higher in the fermented soymilk diet group than in the soymilk diet group (p < 0.05). These results indicate that oral administration of a fermented soymilk diet increases isoflavone concentrations in the blood and skin, effectively scavenging the reactive oxygen species generated by UV irradiation and exerting an estrogen-like activity, with a consequent protective effect on skin photodamage in hairless mice. PMID:27556484

  20. Oral Administration of Fermented Soymilk Products Protects the Skin of Hairless Mice against Ultraviolet Damage.

    PubMed

    Kano, Mitsuyoshi; Kubota, Norihiro; Masuoka, Norie; Hori, Tetsuji; Miyazaki, Kouji; Ishikawa, Fumiyasu

    2016-01-01

    The protective effect of isoflavones on skin damage from ultraviolet (UV) radiation and their bioavailability were investigated in ovariectomized hairless mice fed diets composed of fermented soymilk containing aglycone forms of isoflavones or control soymilk containing glucose-conjugated forms of isoflavones. The erythema intensity of dorsal skin was significantly higher in ovariectomized mice than in sham-operated mice (p < 0.05). The erythema intensity and epidermal thickness of dorsal skin were significantly lower in the fermented soymilk diet group than in the control diet group (each p < 0.05). Levels of cyclobutane pyrimidine dimers in dorsal skin were significantly lower in the fermented soymilk diet group than in the control group (p < 0.05). Serum and dorsal skin isoflavone concentrations were significantly higher in the fermented soymilk diet group than in the soymilk diet group (p < 0.05). These results indicate that oral administration of a fermented soymilk diet increases isoflavone concentrations in the blood and skin, effectively scavenging the reactive oxygen species generated by UV irradiation and exerting an estrogen-like activity, with a consequent protective effect on skin photodamage in hairless mice. PMID:27556484

  1. Dare Public School Administrators Build a New Social Order?: Social Justice and the Possibly Perilous Politics of Educational Leadership

    ERIC Educational Resources Information Center

    Lugg, Catherine A.; Shoho, Alan R.

    2006-01-01

    Purpose: This paper aims to discuss how public school administrators with a social justice perspective have an obligation to permeate society beyond their schools and how they might address the perilous politics associated with advocating social change. Using George Counts' landmark 1932 speech, Dare the School Build a New Social Order? as the…

  2. Order of Administration of Math and Verbal Tests: An Ecological Intervention to Reduce Stereotype Threat on Girls' Math Performance

    ERIC Educational Resources Information Center

    Smeding, Annique; Dumas, Florence; Loose, Florence; Régner, Isabelle

    2013-01-01

    In 2 field experiments, we relied on the very features of real testing situations--where both math and verbal tests are administered--to examine whether order of test administration can, by itself, create vs. alleviate stereotype threat (ST) effects on girls' math performance. We predicted that taking the math test before the verbal test would be…

  3. 77 FR 31611 - Proposed CERCLA Section 122(g)(4) Administrative Agreement and Order on Consent for the Mercury...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... AGENCY Proposed CERCLA Section 122(g)(4) Administrative Agreement and Order on Consent for the Mercury... the Mercury Refining Superfund Site (``Site'') located in the Towns of Guilderland and Colonie, Albany... Hazardous Substance Superfund Mercury Refining Superfund Site Special Account, which combined total...

  4. 77 FR 58867 - Public Land Order No. 7799; Withdrawal of Public Land for the Rock Springs Administrative Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    .... SUMMARY: This order withdraws 4.93 acres of public land from settlement, sale, location, and entry under... the Rock Springs Administrative Site addition. The land has been and will remain open to mineral... valid existing rights, the following described public land is hereby withdrawn from settlement,...

  5. 76 FR 25538 - Criteria Used To Order Administrative Detention of Food for Human or Animal Consumption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ... detention of food for human or animal consumption under the Bioterrorism Act (68 FR 25242 at 25250). The... rule) in the Federal Register of May 9, 2003 (68 FR 25242), proposing procedures for the administrative detention of an article of food. In the Federal Register of June 4, 2004 (69 FR 31660), the Agency...

  6. 78 FR 7994 - Criteria Used To Order Administrative Detention of Food for Human or Animal Consumption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... July 3, 2011. On May 5, 2011, FDA issued an IFR (76 FR 25538) that implemented section 207 of FSMA and... adulterated or misbranded. '' (Response) As stated in the IFR (76 FR 25538 at 25539), decisions regarding...). (Response) As stated in its response to a comment to the 2004 administrative detention final rule (69...

  7. Seventeenth Annual Rank-Order Distribution of Administrative Salaries Paid 1983-1984.

    ERIC Educational Resources Information Center

    Arkansas Univ., Fayetteville. Office of Institutional Research.

    Results of a survey of salaries of full-time administrators at public, doctorate-granting institutions for 1983-1984 are presented. A ranking of salaries paid among 133 universities in 45 states is presented, along with salary data arranged into nine regions defined by the Equal Employment Opportunity Commission. The New York and Boston regions…

  8. Eighteenth Annual Rank-Order Distribution of Administrative Salaries Paid, 1984-85.

    ERIC Educational Resources Information Center

    Arkansas Univ., Fayetteville. Office of Institutional Research.

    Results of a survey of salaries of full-time administrators at public, doctoral-granting institutions for 1984-1985 are presented. A ranking of salaries paid among 151 state-supported universities representing 47 states and 33 university systems representing 27 states is given. Salary data are also arranged into the nine regions defined by the…

  9. Sixteenth Annual Rank-Order Distribution of Administrative Salaries Paid 1982-1983.

    ERIC Educational Resources Information Center

    Arkansas Univ., Fayetteville. Office of Institutional Research.

    Salaries of full-time administrators at public, doctoral-granting institutions for 1982-1983 were surveyed. A ranking of salaries paid among 136 universities in 47 states is presented, along with salary data arranged into nine regions defined by the Equal Employment Opportunity Commission. The New York and Boston regions are combined. A table of…

  10. Characteristics related to protection order use among victims of intimate partner violence.

    PubMed

    Durfee, Alesha; Messing, Jill Theresa

    2012-06-01

    One increasingly important resource for victims of intimate partner violence (IPV) is domestic violence civil protection orders (POs). Using a transdisciplinary framework, this article critically examines the use of POs by IPV victims seeking shelter services. Previous contact with police and medical professionals are the strongest predictors of having obtained a PO; education level, income, age, race, and having children in the shelter are also significant predictors of having obtained a PO. These findings are discussed in the context of previous research on help-seeking behaviors and the growing body of transdisciplinary research on violence against women. PMID:22831846

  11. Resource quality of a symmetry-protected topologically ordered phase for quantum computation.

    PubMed

    Miller, Jacob; Miyake, Akimasa

    2015-03-27

    We investigate entanglement naturally present in the 1D topologically ordered phase protected with the on-site symmetry group of an octahedron as a potential resource for teleportation-based quantum computation. We show that, as long as certain characteristic lengths are finite, all its ground states have the capability to implement any unit-fidelity one-qubit gate operation asymptotically as a key computational building block. This feature is intrinsic to the entire phase, in that perfect gate fidelity coincides with perfect string order parameters under a state-insensitive renormalization procedure. Our approach may pave the way toward a novel program to classify quantum many-body systems based on their operational use for quantum information processing. PMID:25860730

  12. 29 CFR 24.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Litigation § 24.110 Decision and orders of the... issued under the Energy Reorganization Act, other than that portion of the order awarding compensatory... employment, and compensatory damages. In cases arising under the Safe Drinking Water Act or the...

  13. 29 CFR 24.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Litigation § 24.110 Decision and orders of the... issued under the Energy Reorganization Act, other than that portion of the order awarding compensatory... employment, and compensatory damages. In cases arising under the Safe Drinking Water Act or the...

  14. 29 CFR 24.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Litigation § 24.110 Decision and orders of the... issued under the Energy Reorganization Act, other than that portion of the order awarding compensatory... employment, and compensatory damages. In cases arising under the Safe Drinking Water Act or the...

  15. 29 CFR 24.110 - Decision and orders of the Administrative Review Board.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Litigation § 24.110 Decision and orders of the... issued under the Energy Reorganization Act, other than that portion of the order awarding compensatory... employment, and compensatory damages. In cases arising under the Safe Drinking Water Act or the...

  16. 76 FR 78093 - Correction of Administrative Errors; Court Orders and Legal Processes Affecting Thrift Savings...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... payment pursuant to a retirement benefits court order. See 69 FR 18294 (April 7, 2004). The Agency... that the date used to compute earnings on a court-ordered distribution amount is the same as the date used to compute the payee's entitlement. DATES: This interim final rule is effective December 16,...

  17. 77 FR 31157 - Providing an Order of Succession Within the Environmental Protection Agency

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... of Administrator: (a) General Counsel; (b) Assistant Administrator, Office of Solid Waste; (c...; (e) Assistant Administrator for the Office of Water; (f) Assistant Administrator for the Office of... of Research and Development; (i) Assistant Administrator for the Office of International and...

  18. Short-Range-Order Mineral Physical Protection On Black Carbon Stabilization

    NASA Astrophysics Data System (ADS)

    Liang, B.; Weng, Y. T.; Wang, C. C.; Song, Y. F.; Lehmann, J.; Wang, C. H.

    2015-12-01

    Soil organic matter is one of the largest reservoirs in global carbon cycle, and black carbon (BC) represents a chemical resistant component. Black C plays an important role in global climate change. Generally considered recalcitrant due to high aromaticity, the reactive surface and functional groups of BC are crucial for carbon sequestration in soils. Mineral sorption and physical protection is an important mechanism for BC long term stabilization and sequestration in environments. Previous studies on mineral protection of BC were limited to analysis techniques in two-dimensions, for example, by SEM, TEM, and NanoSIMS. Little is known about the scope of organo-mineral association, the in-situ distribution and forms of minerals, and the ultimate interplay of BC and minerals. The aim of this study is to investigate the three-dimensional interaction of organic C and minerals in submicron scale using synchrotron-based Transmission X-ray Microcopy (TXM) and Fourier-Transform Infrared Spectroscopy (FTIR). Abundant poorly-crystallined nano-minerals particles were observed. These short-range-order (SRO) minerals also aggregate into clusters and sheets, and form envelops-like structures on the surface of BC. On top of large surface contact area, the intimate interplay between BC and minerals reinforces the stability of both organic C and minerals, resulting from chemical bonding through cation bridging and ligand exchange. The mineral protection enhances BC stabilization and sequestration and lowers its bioavailability in environment. The results suggest that mineral physical protection for BC sequestration may be more important than previous understanding.

  19. Combined administration of taurine and monoisoamyl DMSA protects arsenic induced oxidative injury in rats.

    PubMed

    Flora, Swaran J S; Chouhan, Swapnila; Kannan, Gurusamy M; Mittal, Megha; Swarnkar, Harimohan

    2008-01-01

    of a higher dose of taurine (100 mg/kg) and MiADMSA provided more pronounced effects in improving the antioxidant status of liver and kidney and reducing body arsenic burden compared to the individual treatment of MiADMSA or taurine. The results suggest that in order to achieve better effects of chelation therapy, co-administration of taurine with MiADMSA might be preferred.

  20. 77 FR 33235 - Public Land Order No. 7789; Partial Withdrawal Revocation and Transfer of Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... Park Service to be managed as part of the Vancouver National Historical Site. DATES: Effective Date... National Park Service to be administered as part of the Fort Vancouver National Historical Site. Order By... transferred to the National Park Service to be administered as part of the Fort Vancouver National...

  1. 29 CFR 24.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Litigation § 24.109 Decision and orders of the... cases arising under the Safe Drinking Water Act or the Toxic Substances Control Act, exemplary damages... brought under the Energy Reorganization Act, when an ALJ issues a decision that the complaint has...

  2. 29 CFR 24.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Litigation § 24.109 Decision and orders of the... cases arising under the Safe Drinking Water Act or the Toxic Substances Control Act, exemplary damages... brought under the Energy Reorganization Act, when an ALJ issues a decision that the complaint has...

  3. 29 CFR 24.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Litigation § 24.109 Decision and orders of the... cases arising under the Safe Drinking Water Act or the Toxic Substances Control Act, exemplary damages... brought under the Energy Reorganization Act, when an ALJ issues a decision that the complaint has...

  4. 29 CFR 24.109 - Decision and orders of the administrative law judge.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENERGY REORGANIZATION ACT OF 1974, AS AMENDED Litigation § 24.109 Decision and orders of the... cases arising under the Safe Drinking Water Act or the Toxic Substances Control Act, exemplary damages... brought under the Energy Reorganization Act, when an ALJ issues a decision that the complaint has...

  5. 20 CFR 655.1040 - Decision and order of administrative law judge.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Process for Attestations Filed by Employers Utilizing F-1 Students in Off-Campus Work § 655.1040 Decision... materially false, the judge shall order that the employer be disqualified from employing F-1 students. (e) In... circumstances shall source data obtained in confidence by ETA, or the names of establishments contacted by...

  6. 20 CFR 655.1040 - Decision and order of administrative law judge.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Process for Attestations Filed by Employers Utilizing F-1 Students in Off-Campus Work § 655.1040 Decision... materially false, the judge shall order that the employer be disqualified from employing F-1 students. (e) In... circumstances shall source data obtained in confidence by ETA, or the names of establishments contacted by...

  7. 20 CFR 655.1040 - Decision and order of administrative law judge.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Process for Attestations Filed by Employers Utilizing F-1 Students in Off-Campus Work § 655.1040 Decision... materially false, the judge shall order that the employer be disqualified from employing F-1 students. (e) In... circumstances shall source data obtained in confidence by ETA, or the names of establishments contacted by...

  8. 20 CFR 655.1040 - Decision and order of administrative law judge.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Process for Attestations Filed by Employers Utilizing F-1 Students in Off-Campus Work § 655.1040 Decision... materially false, the judge shall order that the employer be disqualified from employing F-1 students. (e) In... circumstances shall source data obtained in confidence by ETA, or the names of establishments contacted by...

  9. Hannay Angle: Yet Another Symmetry-Protected Topological Order Parameter in Classical Mechanics

    NASA Astrophysics Data System (ADS)

    Kariyado, Toshikaze; Hatsugai, Yasuhiro

    2016-04-01

    The topological way of thinking now goes beyond quantum solids, and topological characters of classical mechanical systems obeying Newton's law are attracting current interest. To provide a physical insight into the topological numbers in mechanics, we demonstrate the use of the Hannay angle, a "classical" Berry phase, as a symmetry-protected topological order parameter. The Hannay angle is derived using a canonical transformation that maps Newton's equation to a Schrödinger-type equation, and the condition for the quantization is discussed in connection with the symmetry in mechanics. Also, we demonstrate the use of the Hannay angle for a topological characterization of a spring-mass model focusing on the bulk-edge correspondence.

  10. Symmetry-protected topological order in magnetization plateau states of quantum spin chains

    NASA Astrophysics Data System (ADS)

    Takayoshi, Shintaro; Totsuka, Keisuke; Tanaka, Akihiro

    2015-04-01

    A symmetry-protected topologically ordered phase is a short-range entangled state, for which some imposed symmetry prohibits the adiabatic deformation into a trivial state which lacks entanglement. In this paper we argue that magnetization plateau states of one-dimensional antiferromagnets which satisfy the conditions S -m ∈ odd integer, where S is the spin quantum number and m the magnetization per site, can be identified as symmetry-protected topological states if an inversion symmetry about the link center is present. This assertion is reached by mapping the antiferromagnet into a nonlinear sigma model type effective field theory containing a novel Berry phase term (a total derivative term) with a coefficient proportional to the quantity S -m , and then analyzing the topological structure of the ground state wave functional which is inherited from the latter term. A boson-vortex duality transformation is employed to examine the topological stability of the ground state in the absence/presence of a perturbation violating link-center inversion symmetry. Our prediction based on field theories is verified by means of a numerical study of the entanglement spectra of actual spin chains, which we find to exhibit twofold degeneracies when the aforementioned condition is met. We complete this study with a rigorous analysis using matrix product states.

  11. Protective immunity evoked against anthrax lethal toxin after a single intramuscular administration of an adenovirus-based vaccine encoding humanized protective antigen.

    PubMed

    Tan, Yadi; Hackett, Neil R; Boyer, Julie L; Crystal, Ronald G

    2003-11-20

    Because of the need to develop a vaccine to rapidly protect the civilian population in response to a bioterrorism attack with Bacillus anthracis, we designed AdsechPA, a replication-deficient human serotype 5 adenovirus encoding B. anthracis protective antigen (PA) with codons optimized for expression in mammalian cells. With a single intramuscular administration to mice of 10(9) particle units of AdsechPA, a dose that can be scaled to human use, anti-PA antibodies were evoked more rapidly and at a higher level than with a single administration of the new U.S. military recombinant PA/Alhydrogel vaccine. Importantly, AdsechPA afforded approximately 2.7-fold more protection than the recombinant PA vaccine against B. anthracis lethal toxin challenge 4 weeks after a single vaccination. Even at 11 days postvaccination, AdsechPA provided some survival benefit, whereas the rPA/Alhydrogel vaccine provided none. In the context that equivalent human doses of Ad vectors have already been demonstrated to be safe in humans, a single administration of AdsechPA may provide the means to rapidly protect the civilian population against B. anthracis in response to a bioterrorism attack.

  12. She said, he said, judge said: analyzing judicial decision making in civil protection order hearings.

    PubMed

    Lucken, Karol; Rosky, Jeffrey W; Watkins, Cory

    2015-07-01

    A modest body of research has examined judicial decision making in civil protection order (CPO) cases. A major finding of this prior research is that the factors expected to shape judicial responses to CPO requests are often found to be insignificant. Because such decisions are often rendered in an environment of vast judicial discretion and competing allegations, the question of "what matters?" assumes added importance. This study examines permanent/final restraining order (PRO) outcomes for intimate partner violence on a number of variables. Specifically, chi-square analyses were performed examining the associations between granting/denying a PRO and demographic, relationship, hearing, and allegation characteristics associated with the petitioner and respondent. These tests helped to reveal relationships at the bivariate level and aided in further model-building using logistic regression and decision-tree analysis. The findings show that the factors most associated with PRO outcomes, namely, the denial of a PRO, are those reflecting the licit rather than illicit behavior of the respondent.

  13. 6 CFR 29.4 - Protected Critical Infrastructure Information Program administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Protected Critical Infrastructure Information Management System (PCIIMS). The PCII Program Manager shall... be known as the “Protected Critical Infrastructure Information Management System” (PCIIMS), to record... 6 Domestic Security 1 2010-01-01 2010-01-01 false Protected Critical Infrastructure...

  14. 6 CFR 29.4 - Protected Critical Infrastructure Information Program administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Protected Critical Infrastructure Information Management System (PCIIMS). The PCII Program Manager shall... be known as the “Protected Critical Infrastructure Information Management System” (PCIIMS), to record... 6 Domestic Security 1 2014-01-01 2014-01-01 false Protected Critical Infrastructure...

  15. 6 CFR 29.4 - Protected Critical Infrastructure Information Program administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Protected Critical Infrastructure Information Management System (PCIIMS). The PCII Program Manager shall... be known as the “Protected Critical Infrastructure Information Management System” (PCIIMS), to record... 6 Domestic Security 1 2013-01-01 2013-01-01 false Protected Critical Infrastructure...

  16. Pollution prevention and stratospheric ozone layer protection through innovative procurement methods: The chiller basic ordering agreement

    SciTech Connect

    Snyder, R.E.; Coyle, J.E.; Guice, J.R. Jr.; Kale, S.H.

    1997-12-31

    The Department of Energy (DOE) and the General Services Administration (GSA) have devised an affirmative procurement vehicle to encourage replacement of chillers using chlorofluorocarbon (CFC) refrigerants harmful to the Earth`s stratospheric ozone layer. Procurement selections are based on lowest life cycle cost. Linked with a DOE-developed Equipment Specification for 100 to 2,000 ton chillers that is crafted broadly enough to address about 90% of the Federal water-cooled chiller procurements, the Basic Ordering Agreement (BOA) process significantly reduces redundant design, procurement, and other costs associated with Federal purchasing of chillers through the cutting of red tape associated with buying industrial equipment. While serving to minimize the release of ozone-depleting substances (about six million tons of CFCs) to the environment, the installation of more energy-efficient chillers also promotes environmental stewardship in that reduced energy consumption translates into reduced emissions of noxious gases from the generation of electricity. Use of the BOA to purchase chillers consistent with Federal energy efficiency standards will contribute to reductions of almost a million tons annually of nitrous oxides, sulfur dioxide, and other pollutants from power plant emissions. Reduced electricity consumption of approximately 1.5 billion kilowatt hours per year by switching to more efficient chillers equates to an annual monetary savings of $75 million.

  17. Creating an agricultural world order: regional plant protection problems and international phytopathology, 1878-1939.

    PubMed

    Castonguay, Stéphane

    2010-01-01

    Beginning in 1878 with the International Phylloxera Convention of Berne, international conventions have sought to relieve national agricultural industries from two specific burdens. First, by defining phytosanitary practices to be enforced by national plant protection services, these conventions attempted to prevent the introduction of plant diseases and pests into national territories from which they were previously absent. Second, by standardizing these practices - especially through the design of a unique certificate of inspection - the conventions attempted to eliminate barriers such as quarantines affection international agricultural trade. The succession of phytopathological conventions seemed to epitomize the coalescence of an international community against agricultural pests. What actually coalesced was bio-geopolitics wherein plant pathologists and economic entomologists from North America and the British Empire questioned the so-called internationality of the environmental and economic specificities of continental European agriculture, embodied in "international" conventions. Although an international phenomenon, the dissemination of agricultural pests provided opportunities for cooperation on a strictly regional albeit transnational basis that pitted bio-geopolitical spaces against each other. This article retraces the formation of these spaces by analyzing the deliberations of committees and congresses that gathered to define an international agricultural order based on the means to prevent the spread of plant diseases and pests. PMID:20329355

  18. Creating an agricultural world order: regional plant protection problems and international phytopathology, 1878-1939.

    PubMed

    Castonguay, Stéphane

    2010-01-01

    Beginning in 1878 with the International Phylloxera Convention of Berne, international conventions have sought to relieve national agricultural industries from two specific burdens. First, by defining phytosanitary practices to be enforced by national plant protection services, these conventions attempted to prevent the introduction of plant diseases and pests into national territories from which they were previously absent. Second, by standardizing these practices - especially through the design of a unique certificate of inspection - the conventions attempted to eliminate barriers such as quarantines affection international agricultural trade. The succession of phytopathological conventions seemed to epitomize the coalescence of an international community against agricultural pests. What actually coalesced was bio-geopolitics wherein plant pathologists and economic entomologists from North America and the British Empire questioned the so-called internationality of the environmental and economic specificities of continental European agriculture, embodied in "international" conventions. Although an international phenomenon, the dissemination of agricultural pests provided opportunities for cooperation on a strictly regional albeit transnational basis that pitted bio-geopolitical spaces against each other. This article retraces the formation of these spaces by analyzing the deliberations of committees and congresses that gathered to define an international agricultural order based on the means to prevent the spread of plant diseases and pests.

  19. Administration of kefir-fermented milk protects mice against Giardia intestinalis infection.

    PubMed

    Franco, Mariana Correa; Golowczyc, Marina A; De Antoni, Graciela L; Pérez, Pablo F; Humen, Martín; Serradell, María de los Angeles

    2013-12-01

    Giardiasis, caused by the protozoan Giardia intestinalis, is one of the most common intestinal diseases worldwide and constitutes an important problem for the public health systems of various countries. Kefir is a probiotic drink obtained by fermenting milk with 'kefir grains', which consist mainly of bacteria and yeasts that coexist in a complex symbiotic association. In this work, we studied the ability of kefir to protect mice from G. intestinalis infection, and characterized the host immune response to this probiotic in the context of the intestinal infection. Six- to 8-week-old C75BL/6 mice were separated into four groups: controls, kefir mice (receiving 1 : 100 dilution of kefir in drinking water for 14 days), Giardia mice (infected orally with 4×10(7) trophozoites of G. intestinalis at day 7) and Giardia-kefir mice (kefir-treated G. intestinalis-infected mice), and killed at 2 or 7 days post-infection. Kefir administration was able to significantly reduce the intensity of Giardia infection at 7 days post-infection. An increase in the percentage of CD4(+) T cells at 2 days post-infection was observed in the Peyer's patches (PP) of mice belonging to the Giardia group compared with the control and kefir groups, while the percentage of CD4(+) T cells in PP in the Giardia-kefir group was similar to that of controls. At 2 days post-infection, a reduction in the percentage of B220-positive major histocompatibility complex class II medium cells in PP was observed in infected mice compared with the other groups. At 7 days post-infection, Giardia-infected mice showed a reduction in RcFcε-positive cells compared with the control group, suggesting a downregulation of the inflammatory response. However, the percentages of RcFcε-positive cells did not differ from controls in the kefir and Giardia-kefir groups. An increase in IgA-positive cells was observed in the lamina propria of the kefir group compared with controls at 2 days post-infection. Interestingly, the

  20. Mithramycin protects against dopaminergic neurotoxicity in the mouse brain after administration of methamphetamine.

    PubMed

    Hagiwara, Hiroko; Iyo, Masaomi; Hashimoto, Kenji

    2009-12-01

    The present study was undertaken to examine the effects of mithramycin, an inhibitor of transcription factor Specificity protein (Sp)-1, on the behavioral changes and dopaminergic neurotoxicity in the mouse striatum after administration of methamphetamine (METH). Pretreatment with mithramycin (75, 150 or 300 microg/kg) did not alter acute hyperlocomotion in mice after a single administration of METH (3 mg/kg). However, the development of behavioral sensitization in mice after repeated administration of METH (3 mg/kg/day, once daily for 5 days) was significantly blocked by pretreatment with mithramycin (300 microg/kg). Furthermore, pretreatment with mithramycin (300 microg/kg) significantly attenuated the hyperthermia in mice after repeated administration of METH (3 mg/kgx3, 3-h intervals). Moreover, the combination of pretreatment and subsequent administration of mithramycin (75, 150 or 300 microg/kg) significantly attenuated the reductions of dopamine (DA), its major metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) and DA transporter (DAT) in the striatum after repeated administration of METH (3 mg/kgx3, 3-h intervals), and these attenuations were dose dependent. These findings suggest that mithramycin attenuates the development of behavioral sensitization and dopaminergic neurotoxicity in mice after repeated administration of METH. Therefore, mithramycin could have potential for the treatment of METH abusers, particularly since this drug has been approved by the Food and Drug Administration in the United States. In the future, however, another Sp1 inhibitors with fewer side effects might be more appropriate.

  1. Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine.

    PubMed

    Zhang, Lin; Kitaichi, Kiyoyuki; Fujimoto, Yohei; Nakayama, Hironao; Shimizu, Eiji; Iyo, Masaomi; Hashimoto, Kenji

    2006-12-30

    The effects of minocycline on behavioral changes and neurotoxicity in the dopaminergic neurons induced by the administration of methamphetamine (METH) were studied. Pretreatment with minocycline (40 mg/kg) was found to attenuate hyperlocomotion in mice after a single administration of METH (3 mg/kg). The development of behavioral sensitization after repeated administration of METH (3 mg/kg/day, once daily for 5 days) was significantly attenuated by pretreatment with minocycline (40 mg/kg). A reduction in the level of dopamine (DA) and its major metabolite, 3,4-dihydroxyphenyl acetic acid (DOPAC), in the striatum after the repeated administration of METH (3 mg/kg x 3, 3-h interval) was attenuated in a dose-dependent manner by pretreatment with and the subsequent administration of minocycline (10, 20, or 40 mg/kg). Furthermore, minocycline (40 mg/kg) significantly attenuated a reduction in DA transporter (DAT)-immunoreactivity in the striatum after repeated administration of METH. In vivo microdialysis study demonstrated that pretreatment with minocycline (40 mg/kg) significantly attenuated increased extracellular DA levels in the striatum after the administration of METH (3 mg/kg). In addition, minocycline was not found to alter the concentrations of METH in the plasma or the brain after three injections of METH (3 mg/kg), suggesting that minocycline does not alter the pharmacokinetics of METH in mice. Interestingly, METH-induced neurotoxicity in the striatum was significantly attenuated by the post-treatment and subsequent administration of minocycline (40 mg/kg). These findings suggest that minocycline may be able to ameliorate behavioral changes as well as neurotoxicity in dopaminergic terminals after the administration of METH. Therefore, minocycline could be considered as a useful drug for the treatment of several symptoms associated with METH abuse in humans.

  2. 19 CFR 210.34 - Protective orders; reporting requirement; sanctions and other actions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... interest or that justice requires to protect a party or person from annoyance, embarrassment, oppression... Commission immediately upon learning that confidential business information disclosed to him or her...

  3. Issuance of final revised guidance on the use and issuance of administrative orders under Section 7003 of the Resource Conservation and Recovery Act (RCRA). Final report

    SciTech Connect

    Not Available

    1984-09-26

    The directive discusses guidance on the use and issuance of Administrative Orders under Section 7003 of RCRA where there is an emiminent and substantial endangerment to public health and the environment. In order to issue a Section 7003 order, the Administrator must possess evidence that the handling, storage, treatment, transportation or disposal of any solid waste or hazardous waste may present an imminent and substantial endangerment to health or the environment (42 U.S.C. Section 6973). Additionally, Section 7003 requires that the Administrator provide notice to the affected State prior to issuance of the order. Each of these requirements is discussed in the directive.

  4. Protection against Amorimia septentrionalis poisoning in goats by the continuous administration of sodium monofluoroacetate-degrading bacteria.

    PubMed

    da Silva, Layze C A; Pessoa, Danielle A N; Lopes, Jose R G; de Albuquerque, Laio G; da Silva, Leomyr S A; Garino Junior, Felicio; Riet-Correa, Franklin

    2016-03-01

    The intraruminal inoculation of sodium monofluoroacetate (MFA)-degrading bacteria has been proposed as a method to prevent poisoning by MFA-containing plants. In previous experiments, MFA-degrading bacteria were inoculated intraruminally before or concurrent with plant challenge, with both strategies conferring partial protection to poisoning. To evaluate the protection to Amorimia septentrionalis poisoning provided by the continuous inoculation of MFA-degrading bacteria isolated from plants and soils, 18 goats were divided into three experimental groups of six animals each: Group 1 goats received daily doses of a mixture of Paenibacillus sp. and Cupriavidus sp., and Group 2 goats received a mixture of Ralstonia sp. and Burkholderia sp., for 40 days, while Group 3 goats were not inoculated. Ten days after initiation of bacterial inoculation in Groups 1 and 2, all goats were challenged daily with 5 g/kg body weight of green leaves from A. septentrionalis. Four goats from Group 1 consumed the leaves throughout the 30-day consumption period and showed clinical signs such as transient tachycardia and engorgement of the jugular. The two remaining animals from Group 1 showed obvious signs of intoxication, and plant administration was suspended on days 17 and 19. The goats in Group 2 consumed the leaves throughout the 30-day study without showing signs of poisoning. The goats from Group 3 (control) manifested severe clinical signs of poisoning between the 3rd and 10th days following the start of the A. septentrionalis challenge. Under the conditions of this experiment continuous intraruminal administration of Ralstonia sp. and Burkholderia sp. provided complete protection to poisoning by A. septentrionalis in goats, while continuous intraruminal administration of Paenibacillus sp. and Cupriavidus sp. provided partial protection. PMID:26747472

  5. 40 CFR 91.605 - Testing by the Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Testing by the Administrator. 91.605 Section 91.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Regulations § 91.605 Testing by the Administrator. (a) The Administrator may require by test order under §...

  6. 40 CFR 91.605 - Testing by the Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Testing by the Administrator. 91.605 Section 91.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Regulations § 91.605 Testing by the Administrator. (a) The Administrator may require by test order under §...

  7. 40 CFR 91.605 - Testing by the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Testing by the Administrator. 91.605 Section 91.605 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Regulations § 91.605 Testing by the Administrator. (a) The Administrator may require by test order under §...

  8. 28 CFR 68.53 - Review of an interlocutory order of an Administrative Law Judge in cases arising under section...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administrative Law Judge in cases arising under section 274A or 274C. 68.53 Section 68.53 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE ADMINISTRATIVE LAW JUDGES IN CASES INVOLVING ALLEGATIONS OF UNLAWFUL EMPLOYMENT OF ALIENS, UNFAIR...

  9. Exogenous NAD(+) administration significantly protects against myocardial ischemia/reperfusion injury in rat model.

    PubMed

    Zhang, Youjun; Wang, Ban; Fu, Xingli; Guan, Shaofeng; Han, Wenzheng; Zhang, Jie; Gan, Qian; Fang, Weiyi; Ying, Weihai; Qu, Xinkai

    2016-01-01

    Acute myocardial infarction is one of the leading causes for death around the world. Although essential for successful interventional therapy, it is inevitably complicated by reperfusion injury. Thus effective approaches to reduce ischemia/reperfusion (I/R) injury are still critically needed. To test our hypothesis that intravenous administration of NAD(+) can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R. Our study found that administration of 10-20 mg/kg NAD(+) can dose dependently reduce myocardial infarct induced by I/R, with an approximately 85% reduction of the infarct at the dosage of 20 mg/kg NAD(+). We further found that the injection of NAD(+) can significantly decrease I/R-induced apoptotic damage in the heart: NAD(+) administration can both decrease the TUNEL signals, Bax, cleaved caspase-3 levels and increase the Bcl-XL levels in the rats that are subjected to myocardial I/R injury. NAD(+) administration can also significantly attenuate I/R-induced decreases in SOD activity and SOD-2 protein levels in the hearts. NAD(+) can profoundly decrease myocardial I/R injury at least partially by attenuating apoptotic damage and enhancing the antioxidant capacity, thus suggesting that NAD(+) may become a promising therapeutic agent for myocardial I/R injury. PMID:27648125

  10. Exogenous NAD+ administration significantly protects against myocardial ischemia/reperfusion injury in rat model

    PubMed Central

    Zhang, Youjun; Wang, Ban; Fu, Xingli; Guan, Shaofeng; Han, Wenzheng; Zhang, Jie; Gan, Qian; Fang, Weiyi; Ying, Weihai; Qu, Xinkai

    2016-01-01

    Acute myocardial infarction is one of the leading causes for death around the world. Although essential for successful interventional therapy, it is inevitably complicated by reperfusion injury. Thus effective approaches to reduce ischemia/reperfusion (I/R) injury are still critically needed. To test our hypothesis that intravenous administration of NAD+ can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R. Our study found that administration of 10-20 mg/kg NAD+ can dose dependently reduce myocardial infarct induced by I/R, with an approximately 85% reduction of the infarct at the dosage of 20 mg/kg NAD+. We further found that the injection of NAD+ can significantly decrease I/R-induced apoptotic damage in the heart: NAD+ administration can both decrease the TUNEL signals, Bax, cleaved caspase-3 levels and increase the Bcl-XL levels in the rats that are subjected to myocardial I/R injury. NAD+ administration can also significantly attenuate I/R-induced decreases in SOD activity and SOD-2 protein levels in the hearts. NAD+ can profoundly decrease myocardial I/R injury at least partially by attenuating apoptotic damage and enhancing the antioxidant capacity, thus suggesting that NAD+ may become a promising therapeutic agent for myocardial I/R injury. PMID:27648125

  11. Exogenous NAD+ administration significantly protects against myocardial ischemia/reperfusion injury in rat model

    PubMed Central

    Zhang, Youjun; Wang, Ban; Fu, Xingli; Guan, Shaofeng; Han, Wenzheng; Zhang, Jie; Gan, Qian; Fang, Weiyi; Ying, Weihai; Qu, Xinkai

    2016-01-01

    Acute myocardial infarction is one of the leading causes for death around the world. Although essential for successful interventional therapy, it is inevitably complicated by reperfusion injury. Thus effective approaches to reduce ischemia/reperfusion (I/R) injury are still critically needed. To test our hypothesis that intravenous administration of NAD+ can attenuate I/R injury by reducing apoptotic damage and enhancing antioxidant capacity, we used a rat mode of myocardial I/R. Our study found that administration of 10-20 mg/kg NAD+ can dose dependently reduce myocardial infarct induced by I/R, with an approximately 85% reduction of the infarct at the dosage of 20 mg/kg NAD+. We further found that the injection of NAD+ can significantly decrease I/R-induced apoptotic damage in the heart: NAD+ administration can both decrease the TUNEL signals, Bax, cleaved caspase-3 levels and increase the Bcl-XL levels in the rats that are subjected to myocardial I/R injury. NAD+ administration can also significantly attenuate I/R-induced decreases in SOD activity and SOD-2 protein levels in the hearts. NAD+ can profoundly decrease myocardial I/R injury at least partially by attenuating apoptotic damage and enhancing the antioxidant capacity, thus suggesting that NAD+ may become a promising therapeutic agent for myocardial I/R injury.

  12. 77 FR 70463 - Public Land Order No. 7801; Withdrawal of Public Lands for Protection of Proposed Expansion of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE INTERIOR Public Land Order No. 7801; Withdrawal of Public Lands for Protection of Proposed Expansion of Twentynine Palms, CA Correction In notice document 2012-23479 beginning on page 58864 of the issue of Monday, September 24, 2012 make the...

  13. [The protective activity of 2 normal immunoglobulin preparations for intravenous administration in experimental Pseudomonas aeruginosa infection].

    PubMed

    Vasilev, Ch L; Veleva, K V; Tekelieva, R Kh; Pencheva, P I

    1991-02-01

    The antibody levels in 18 batches of the preparations of human immunoglobulin, Immunovenin and Immunovenin-Intact, for intravenous injection were determined in the enzyme immunoassay with the use of the mixture of P. aeruginosa lipopolysaccharide antigens of seven immunotypes. The average antibody titers in these preparations were identical. The preparations were found to have protective action against P. aeruginosa experimental infection in mice.

  14. 97 Savvy Secrets for Protecting Self and School: A Practical Guide for Today's Teachers and Administrators.

    ERIC Educational Resources Information Center

    Sesno, Alice Healy

    A teacher's professional integrity faces numerous challenges in the classroom. To help educators safeguard against potentially career-ending incidents, numerous "survival rules" are provided in this text. It argues that teachers must safeguard themselves with self-protecting knowledge and, in some instances, must reprogram themselves with new…

  15. Do family order and neighbor intervention against intimate partner violence protect children from abuse? Findings from Kathmandu.

    PubMed

    Emery, Clifton R; Thapa, Sirjana; Do, Mi Hyang; Chan, Ko Ling

    2015-03-01

    Drawing on previous research on intimate partner violence, child maltreatment, and informal social control, we hypothesized relationships between child abuse severity and (1) protective informal social control of intimate partner violence (ISC_IPV) by neighbors, (2) intimate terrorism, (3) family order, and (4) the power of mothers in intimate relationships. In what we believe may be a first study of physical child abuse by parents in Nepal, we used a three stage cluster approach to draw a random sample of 300 families in Kathmandu. Random effects regression models were used to test the study hypotheses. The analyses found support for hypotheses one and two, but with an important caveat. Although observed (actual) protective ISC_IPV had the hypothesized negative association with child abuse severity, in one of our models perceived protective ISC_IPV was positively associated with child abuse severity. The models clarify that the overall direction of protective ISC_IPV appears to be negative (protective), but the positive finding is important to consider for both research and practice. A significant relationship between family order and child abuse severity was found, but the direction was negative rather than positive as in hypothesis three. Implications for neighborhood research and typological research on IPV and child maltreatment are discussed.

  16. 75 FR 14152 - Executive Order 13508; Chesapeake Bay Protection and Restoration Section 502; Guidance for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ...-effective tools and practices that reduce water pollution and requests public comment. The document was... Chesapeake Bay watershed describing proven, cost-effective tools and practices that reduce water pollution...: Water Docket, Environmental Protection Agency, Mailcode: 2822T, 1200 Pennsylvania Ave., NW.,...

  17. Chronic administration of troxerutin protects mouse kidney against D-galactose-induced oxidative DNA damage.

    PubMed

    Liu, Chan-Min; Ma, Jie-Qiong; Lou, Yao

    2010-10-01

    Troxerutin, a natural bioflavonoid, has been reported to have many benefits and medicinal properties. In this study, we evaluated the protective effect of troxerutin against D-gal-induced oxidative DNA damage in mouse kidney, and explored the potential mechanism of its action. Our data showed that troxerutin significantly decreased levels of urea, uric acid and creatinine in serum and the renal histological injury in D-gal-treated mice. Troxerutin markedly restored Cu/Zn-SOD, CAT and GPx activities in the kidney of D-gal-treated mouse. Furthermore, the increase of 8-hydroxydeoxyguanosine (a marker of oxidative DNA damage) induced by d-gal was effectively suppressed by troxerutin. Internucleosomal DNA ladder fragmentation and the number of terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP) nick-end-labeling (TUNEL)-positive cells in D-gal-treated mice were inhibited by troxerutin, which might be attributed to its antioxidant property by decreasing activities of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) and levels of reactive oxygen species (ROS). In conclusion, these results suggested that troxerutin could protect the mouse kidney against D-gal-induced injury by improving renal function, attenuating histopathologic changes, reducing ROS production, renewing the activities of antioxidant enzymes and decreasing DNA oxidative damage. This study provided novel insights into the protective mechanisms of troxerutin in D-gal-induced kidney injury.

  18. Administration of defined microbiota is protective in a murine Salmonella infection model

    PubMed Central

    Martz, Sarah-Lynn E.; McDonald, Julie A. K.; Sun, Jun; Zhang, Yong-guo; Gloor, Gregory B.; Noordhof, Curtis; He, Shu-Mei; Gerbaba, Teklu K.; Blennerhassett, Michael; Hurlbut, David J.; Allen-Vercoe, Emma; Claud, Erika C.; Petrof, Elaine O.

    2015-01-01

    Salmonella typhimurium is a major cause of diarrhea and causes significant morbidity and mortality worldwide, and perturbations of the gut microbiota are known to increase susceptibility to enteric infections. The purpose of this study was to investigate whether a Microbial Ecosystem Therapeutic (MET-1) consisting of 33 bacterial strains, isolated from human stool and previously used to cure patients with recurrent Clostridium difficile infection, could also protect against S. typhimurium disease. C57BL/6 mice were pretreated with streptomycin prior to receiving MET-1 or control, then gavaged with S. typhimurium. Weight loss, serum cytokine levels, and S. typhimurium splenic translocation were measured. NF-κB nuclear staining, neutrophil accumulation, and localization of tight junction proteins (claudin-1, ZO-1) were visualized by immunofluorescence. Infected mice receiving MET-1 lost less weight, had reduced serum cytokines, reduced NF-κB nuclear staining, and decreased neutrophil infiltration in the cecum. MET-1 also preserved cecum tight junction protein expression, and reduced S. typhimurium translocation to the spleen. Notably, MET-1 did not decrease CFUs of Salmonella in the intestine. MET-1 may attenuate systemic infection by preserving tight junctions, thereby inhibiting S. typhimurium from gaining access to the systemic circulation. We conclude that MET-1 may be protective against enteric infections besides C. difficile infection. PMID:26531327

  19. Vertical administration of vanadium through lactation induces behavioural and neuromorphological changes: protective role of vitamin E.

    PubMed

    Olopade, J O; Fatola, I O; Olopade, F E

    2011-11-23

    The work investigated the protective role of vitamin E on vanadium induced neurotoxicity. Three adult female rats were divided into three groups, A-C with each dam and her pups forming a group. Group A served as control. The dam in Group B was given 3mg/kg b.w./day of vanadium from PND 1 while the Group C dam were given 3mg/kg b.w./day of vanadium, for 14 days and 500mg/kg b.w. of vitamin E 72 hourly in the same time frame. The results showed that pups from Group B, exhibited behavioural deficits in most tests, a significant reduction in body weight gain and absolute brain weight; in addition immunohistochemistry showed reactive astrogliosis induced by vanadium exposure. All these findings were however attenuated in pups whose dam was exposed to vanadium and vitamin E depicting the significant protective effects of this antioxidant against vanadium. This study is novel in that both vanadium and vitamin E were introduced through the lactation route. We conclude that though caution remains essential in the posology of vitamin E, the management of lactating mothers who have been exposed to vanadium occupationally, environmentally or therapeutically with supplementation of this antioxidant may be beneficial at least in the short term to both mother and offspring.

  20. 75 FR 443 - Public Land Order No. 7738; Extension of Public Land Order No. 6760, Nevada

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-05

    ... Act of 1976, 43 U.S.C. 1714, it is ordered as follows: Public Land Order No. 6760 (54 FR 53612, (1989... protection of the Federal investment in the U.S. Forest Service Austin Administrative Site in Lander County... continue protection of the Federal investment in the Austin Administrative Site. The withdrawal extended...

  1. Protection against Paracoccidioides brasiliensis infection conferred by the prophylactic administration of native and recombinant ArtinM.

    PubMed

    Coltri, Kely C; Oliveira, Leandro L; Ruas, Luciana P; Vendruscolo, Patrícia E; Goldman, Maria Helena; Panunto-Castelo, Ademilson; Roque-Barreira, Maria-Cristina

    2010-09-01

    We determined the prophylactic effect of both the d-mannose-binding lectin ArtinM extracted from the seeds of Artocarpus integrifolia (jackfruit) and its recombinant counterpart during the course of experimental paracoccidioidomycosis induced in BALB/c mice. Four experimental protocols of prophylaxis were employed to evaluate the most protective regimen of ArtinM administration. It was demonstrated that the best effect was obtained by administration of two ArtinM doses on days 10 and 3 before the challenge with Paracoccidioides brasiliensis. By following this protocol, the lungs of mice that received native or recombinant ArtinM exhibited reduced fungal burden and granuloma incidence. In addition, the protocol augmented contents of IL-12, IFN-gamma, TNF-alpha and NO. On the other hand, the control group consisting of untreated infected mice had higher pulmonary levels of IL-4 and IL-10. In conclusion, prophylaxis with ArtinM significantly reproduces the effect of its therapeutic administration, i.e, it confers resistance to P. brasiliensis infection in mouse models by promoting IL-12 production and favours Th1-immunity.

  2. Prophylactic Administration of Amifostine Protects Vessel Thickness in the Setting of Irradiated Bone

    PubMed Central

    Page, Erin E.; Deshpande, Sagar S.; Nelson, Noah S.; Felice, Peter A.; Donneys, Alexis; Rodriguez, Jose J.; Deshpande, Samir S.; Buchman, Steven R.

    2014-01-01

    Although often beneficial in the treatment of head and neck cancer (HNC), radiation therapy (XRT) leads to the depletion of vascular supply and eventually decreased perfusion of the tissue. Specifically, previous studies have demonstrated the depletion of vessel volume fraction (VVF) and vessel thickness (VT) associated with XRT. Amifostine (AMF) provides protection from the detrimental effects of radiation damage, allowing for reliable post-irradiation fracture healing in the murine mandible. The purpose of this study is to investigate the prophylactic ability of AMF to protect the vascular network in an irradiated field. Sprague-Dawley rats (n=17) were divided into 3 groups: control (C, n=5), radiated (XRT, n=7), and radiated mandibles treated with Amifostine (AMF XRT, n=5). Both groups receiving radiation underwent a previously established, human equivalent dose of XRT totaling 35 Gray, equally fractionated over 5 days. The AMF XRT group received a weight dependent (0.5mg AMF/5g body weight) subcutaneous injection of AMF 45 minutes prior to XRT. Following a 56-day recovery period, mandibles were perfused, dissected, and imaged with µCT. ANOVA was used for comparisons between groups and p < 0.05 was considered statistically significant. Stereologic analysis demonstrated a significant and quantifiable restoration of VT in AMF treated mandibles as compared to those treated with radiation alone (0.061±.011mm versus 0.042±0.004mm, p=0.027). Interestingly, further analysis demonstrated no significant difference in VT between control mandibles and those treated with AMF (0.067±0.016mm versus 0.061±0.011mm, p=0.633). AMF treatment also showed an increase in VVF, however those results were not statistically significant from VVF values demonstrated by the XRT group. Our data support the contention that AMF therapy acts prophylactically to protect vessel thickness, as AMF-treated mandibles demonstrate VT levels that are not statistically different from controls in the

  3. Health Care Financing Administration--Medicare and Medicaid programs; protection of patients' funds. Final regulation.

    PubMed

    1980-07-24

    This rule sets forth expanded standards for protection of personal funds of patients in skilled nursing facilities (SNFs) and intermediate care facilities (ICFs) that participate in the Medicare or Medicaid programs. The changes are required for SNFs by Section 21(a) of Pub. L. 95-142, the Medicare-Medcaid Anti-Fraud and Abuse Amendments of 1977, and for ICFs by Section 8(c) of Pub. L. 95-292, the End-Stage Renal Disease Amendments of 1978. The intent is to safeguard patient funds from misuse by facilities, and to assure that personal funds held by the the facilities are fully accounted for and made available to patients when they need or want them. PMID:10297939

  4. Therapeutic Administration of a Monoclonal Anti-Il-1β Antibody Protects Against Experimental Melioidosis

    PubMed Central

    Weehuizen, Tassili A. F.; Lankelma, Jacqueline M.; De Jong, Hanna K.; De Boer, Onno J.; Roelofs, Joris J. T. H.; Day, Nicholas P.; Gram, Hermann; De Vos, Alex F.; Wiersinga, W. Joost

    2016-01-01

    ABSTRACT Background: Melioidosis, caused by the gram-negative bacterium Burkholderia pseudomallei, is a common cause of community-acquired sepsis in Southeast Asia and Northern Australia. The NLRP3 inflammasome and its downstream product interleukin-1 beta (IL-1β) have been proposed to play crucial roles in melioidosis. In this study, we characterized the role of IL-1β more closely and we assessed its therapeutic potential. Methods: mRNA expression of inflammasome components was determined in isolated leukocytes of 32 healthy controls and 34 patients with sepsis caused by B pseudomallei. Wild-type (WT), NLRP3-deficient (Nlrp3−/−), and Asc−/− mice were infected with B pseudomallei. In additional experiments, infected WT mice were treated with an anti-IL-1β antibody. After 24, 48, and 72 hours (h) mice were sacrificed and organs were harvested. Furthermore, survival studies were performed. Results: Patients with melioidosis exhibited lower mRNA levels of caspase-1, NLRP3, and ASC. Bacterial dissemination and organ damage were increased in B pseudomallei-infected Nlrp3−/− and Asc−/− mice, together with a reduced pulmonary cell influx. Anti-IL-1β treatment of B pseudomallei challenged mice resulted in strongly reduced bacterial counts, organ damage, and pulmonary granulocyte influx together with reduced mortality. Postponement of anti-IL-1β treatment for 24 h postinfection still protected mice during melioidosis. Conclusion: Expression of caspase-1, NLRP3, and ASC is altered in melioidosis patients. In mice, both NLRP3 and ASC contribute to the host defense against melioidosis. Anti-IL-1β treatment protects mice against B pseudomallei infection and might be a novel treatment strategy in melioidosis. PMID:27219859

  5. Protective effects of local administration of ciprofloxacin on the risk of pneumococcal meningitis following cochlear implantation

    PubMed Central

    Wei, Benjamin P.C.; Robins-Browne, Roy M.; Shepherd, Robert K.; Azzopardi, Kristy; Clark, Graeme M.; O'Leary, Stephen J.

    2007-01-01

    Objectives To determine if ciprofloxacin retains its antimicrobial activity after storage with Healon® at ambient temperature and at 37°C over 5 weeks and then to establish whether the application of ciprofloxacin/Healon® onto scala tympani electrode arrays reduces the risk of meningitis in implanted rats inoculated with S. pneumoniae. Study design in vitro laboratory and in vivo animal studies Methods The antibacterial activity of three concentrations of ciprofloxacin/Healon® (7.5, 75 and 750 μg/ml) was examined over 5 weeks at both ambient temperature (23°C) and body temperature (37°C). Thirty-six rats (18 implanted with ciprofloxacin (750 mg/ml)/Healon®-coated electrode array and 18 without the coating) were infected with S. pneumoniae 4 weeks after implantation via three different routes of infection (hematogenous, middle ear and inner ear) and observed for the development of meningitis. Results The antibacterial activity of ciprofloxacin/Healon® was maintained over 5 weeks at both 23°C and 37°C. The implanted rats with the ciprofloxacin/Healon-coated electrode array were protected from meningitis when the bacteria were given via the hematogenous route (Fisher’s exact test P =0.008, but not when the bacteria were inoculated directly into the middle or inner ear. However, the time to develop meningitis was significantly longer in rats implanted with a coated array, irrespective of the route of inoculation (P <0.05, log rank test). Conclusion Our animal model demonstrated that a ciprofloxacin-coated electrode array can protect healthy implanted rats from meningitis when the route of infection is hematogenous, and can delay the onset of meningitis when bacteria are inoculated directly into the middle or inner ear. PMID:17146386

  6. Oral administration of a recombinant attenuated Yersinia pseudotuberculosis strain elicits protective immunity against plague.

    PubMed

    Sun, Wei; Sanapala, Shilpa; Rahav, Hannah; Curtiss, Roy

    2015-11-27

    A Yersinia pseudotuberculosis PB1+ (Yptb PB1+) mutant strain combined with chromosome insertion of the caf1R-caf1A-caf1M-caf1 operon and deletions of yopJ and yopK, χ10068 [pYV-ω2 (ΔyopJ315 ΔyopK108) ΔlacZ044::caf1R-caf1M-caf1A-caf1] was constructed. Results indicated that gene insertion and deletion did not affect the growth rate of χ10068 compared to wild-type Yptb cultured at 26 °C. In addition, the F1 antigen in χ10068 was synthesized and secreted on the surface of bacteria at 37 °C (mammalian body temperature), not at ambient culture temperature (26 °C). Immunization with χ10068 primed antibody responses and specific T-cell responses to F1 and YpL (Y. pestis whole cell lysate). Oral immunization with a single dose of χ10068 provided 70% protection against a subcutaneous (s.c.) challenge with ∼ 2.6 × 10(5) LD50 of Y. pestis KIM6+ (pCD1Ap) (KIM6+Ap) and 90% protection against an intranasal (i.n.) challenge with ∼ 500 LD50 of KIM6+Ap in mice. Our results suggest that χ10068 can be used as an effective precursor to make a safe vaccine to prevent plague in humans and to eliminate plague circulation among humans and animals.

  7. 78 FR 40773 - Order Imposing Requirements for the Protection of Certain Safeguards Information (Effective...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-08

    ... entities participating under 10 CFR 2.315(c), must be filed in accordance with the NRC E-Filing rule (72 FR... Immediately); In the Matter of Licensee Identified in Attachment 1 and All Other Persons Who Obtain Safeguards Information Described Herein I The Licensee, identified in Attachment 1 \\1\\ to this Order, holds a ]...

  8. 75 FR 47475 - Acetamiprid, Mepiquat; Order Denying NRDC’s Objections on Remand: Environmental Protection Agency

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    .... (70 FR 46706 (August 10, 2005)). NRDC sought judicial review of the August, 2005 order, and the U.S..., total bilirubin, albumin, hormones, and enzymes such as alkaline phosphatase, alanine aminotransfersase... Department of Agriculture. (Ref. 1 at 12). Information on residue values comes from a range of...

  9. Co-administration of Apelin and T4 Protects Inotropic and Chronotropic Changes Occurring in Hypothyroid Rats

    PubMed Central

    Akhondali, Zahra; Badavi, Mohammad; Dianat, Mahin; Faraji, Farzaneh

    2015-01-01

    Background One of the most important thyroid hormone targets is the cardiovascular system. Hemodynamic changes, such as decreased resting heart rate (HR), myocardial contractility, and cardiac output, and increased diastolic pressure and systemic vascular resistance, have been observed in hypothyroid patients. Moreover, in these patients, ECG changes include sinus bradycardia and low voltage complexes (P waves or QRS complexes). Objective This study aimed at evaluating the prophylactic effect of apelin on HR changes and QRS voltage that occur in propylthiouracil (PTU)-induced hypothyroid rats. Method In this study, 48 adult male Wistar rats weighing 170-235g were randomly divided into 6 groups: Control group (normal saline ip injection + tap water gavage); P group (PTU 0.05%, in drinking water); A group (apelin 200 µg.kg-1.day-1, ip); PA group [co-administration of PTU and apelin]; PT group [co-administration of PTU + T4 (0.2 mg/g per day, gavage)]; and PAT group (co-administration of PTU, apelin and T4). All experiments were performed for 28 consecutive days, and then the animals were anesthetized with an ip injection of ketamine (80 mg/kg) and xylazine (12 mg/kg). Lead II electrocardiogram was recorded to calculate HR and QRS voltage. Results Heart rate and QRS voltage increased more significantly in the hypothyroid group that consumed both apelin and T4 (201 ± 4 beat/min, 0.71 ± 0.02 mv vs. hypothyroid 145 ± 9 beat/min, 0.563 ± 0.015 mv; respectively). Conclusion The co-administration of apelin and T4 showed a protective effect on QRS voltage and HR in PTU‑induced hypothyroid rats. PMID:26247243

  10. Ethanol and Phencyclidine Interact with Respect to Nucleus Accumbens Dopamine Release: Differential Effects of Administration Order and Pretreatment Protocol

    PubMed Central

    Pickering, Chris; Chau, Pei Pei; Söderpalm, Bo; Ericson, Mia

    2010-01-01

    Executive dysfunction is a common symptom among alcohol-dependent individuals. Phencyclidine (PCP) injection induces dysfunction in the prefrontal cortex of animals but little is known about how PCP affects the response to ethanol. Using the in vivo microdialysis technique in male Wistar rats, we investigated how systemic injection of 5 mg/kg PCP would affect the dopamine release induced by local infusion of 300 mM ethanol into the nucleus accumbens. PCP given 60 min before ethanol entirely blocked ethanol-induced dopamine release. However, when ethanol was administered 60 min before PCP, both drugs induced dopamine release and PCP's effect was potentiated by ethanol (180% increase vs 150%). To test the role of prefrontal cortex dysfunction in ethanol reinforcement, animals were pretreated for 5 days with 2.58 mg/kg PCP according to previously used ‘PFC hypofunction protocols’. This, however, did not change the relative response to PCP or ethanol compared to saline-treated controls. qPCR illustrated that this low PCP dose did not significantly change expression of glucose transporters Glut1 (SLC2A1) or Glut3 (SLC2A3), monocarboxylate transporter MCT2 (SLC16A7), glutamate transporters GLT-1 (SLC1A2) or GLAST (SLC1A3), the immediate early gene Arc (Arg3.1) or GABAergic neuron markers GAT-1 (SLC6A1) and parvalbumin. Therefore, we concluded that PCP at a dose of 2.58 mg/kg for 5 days did not induce hypofunction in Wistar rats. However, PCP and ethanol do have overlapping mechanisms of action and these drugs differentially affect mesolimbic dopaminergic transmission depending on the order of administration. PMID:20589092

  11. Subcutaneous Administration of Bovine Superoxide Dismutase Protects Lungs from Radiation-Induced Lung Injury

    PubMed Central

    Jackson, Isabel L.; Vujaskovic, Zeljko

    2016-01-01

    Background The objective of the present study was to determine whether single administration of the antioxidant enzyme bovine superoxide dismutase (bSOD) after radiation (RT) exposure mitigates development of pulmonary toxicity in rats. Methods Female F344 rats (n=60) were divided among six experimental groups: (1) RT, single dose of 21 Gy to the right hemithorax; (2) RT+5 mg/kg bSOD; (3) RT+15 mg/kg bSOD; (4) No RT; (5) sham RT+5mg/kg bSOD; and (6) sham RT+15mg/kg bSOD. A single subcutaneous injection of bSOD (5 or 15 mg/kg) was administered 24 hours postradiation. The effects of bSOD on radiation-induced lung injury were assessed by measurement of body weight, breathing frequency and histopathological changes. Immunohistochemistry was used to evaluate oxidative stress (8-OHdG+, NOX4+, nitrotyrosine+, 4HNE+ cells), macrophage activation (ED1+), and expression of profibrotic TGF-β in irradiated tissue. Results Radiation led to an increase in all evaluated parameters. Treatment with 15mg/kg bSOD significantly decreased levels of all evaluated parameters including tissue damage and breathing frequency starting 6 weeks post-radiation. Animals treated with 5 mg/kg bSOD trended toward a suppression of radiation-induced lung damage but did not reach statistical significance. Conclusions The single application of bSOD (15mg/kg) ameliorates radiation induced lung injury through suppression of ROS/RNS dependent tissue damage. PMID:26110460

  12. Systemic Administration of Oleoylethanolamide Protects from Neuroinflammation and Anhedonia Induced by LPS in Rats

    PubMed Central

    Sayd, Aline; Antón, María; Alén, Francisco; Caso, Javier Rubén; Pavón, Javier; Leza, Juan Carlos; Rodríguez de Fonseca, Fernando

    2015-01-01

    Background: The acylethanolamides oleoylethanolamide and palmitoylethanolamide are endogenous lipid mediators with proposed neuroprotectant properties in central nervous system (CNS) pathologies. The precise mechanisms remain partly unknown, but growing evidence suggests an antiinflammatory/antioxidant profile. Methods: We tested whether oleoylethanolamide/palmitoylethanolamide (10mg/kg, i.p.) attenuate neuroinflammation and acute phase responses (hypothalamus-pituitary-adrenal (HPA) stress axis stress axis activation, thermoregulation, and anhedonia) induced by lipopolysaccharide (0.5mg/kg, i.p.) in rats. Results: Lipopolysaccharide increased mRNA levels of the proinflammatory cytokines tumor necrosis factor-α, interleukin-1β, and interleukin-6, nuclear transcription factor-κB activity, and the expression of its inhibitory protein IκBα in cytoplasm, the inducible isoforms of nitric oxide synthase and cyclooxygenase-2, microsomal prostaglandin E2 synthase mRNA, and proinflammatory prostaglandin E2 content in frontal cortex 150 minutes after administration. As a result, the markers of nitrosative/oxidative stress nitrites (NO2 -) and malondialdehyde were increased. Pretreatment with oleoylethanolamide/ palmitoylethanolamide reduced plasma tumor necrosis factor-α levels after lipopolysaccharide, but only oleoylethanolamide significantly reduced brain tumor necrosis factor-α mRNA. Oleoylethanolamide and palmitoylethanolamide prevented lipopolysaccharide-induced nuclear transcription factor-κB (NF-κB)/IκBα upregulation in nuclear and cytosolic extracts, respectively, the expression of inducible isoforms of nitric oxide synthase, cyclooxygenase-2, and microsomal prostaglandin E2 synthase and the levels of prostaglandin E2. Additionally, both acylethanolamides reduced lipopolysaccharide-induced oxidative/nitrosative stress. Neither oleoylethanolamide nor palmitoylethanolamide modified plasma corticosterone levels after lipopolysaccharide, but both

  13. Protection against atypical Aeromonas salmonicida infection in carp (Cyprinus carpio L.) by oral administration of humus extract.

    PubMed

    Kodama, Hiroshi; Denso; Nakagawa, Tsuyoshi

    2007-04-01

    Humic substances are formed during the decomposition of organic matter in humus, and are found in many natural environments in which organic materials and microorganisms have been present. In the present study, oral administration of humus extract to common carp (Cyprinus carpio L.) induced effective protection against experimental atypical Aeromonas salmonicida infection. Mortality of fish and development of skin lesions such as hemorrhages and ulcers were significantly suppressed in carp treated with 10%, 5% or 1% humus extract adsorbed on dry feeding pellets. The median surviving days was also greater in fish treated with 10% or 5% humus extract than in untreated fish. Atypical A. salmonicida was isolated from ulcerative lesions of part of dead fish, but Aeromonas hydrophila and Flavobacterium sp. were also isolated from these fish, verifying bacterial population changes during the progression of skin lesions. These results clearly show that treatment of fish with humus extract is effective in preventing A. salmonicida disease.

  14. 75 FR 44163 - Antidumping and Countervailing Duty Proceedings: Electronic Filing Procedures; Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE... Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures AGENCY: Import Administration, International Trade Administration, Department of Commerce. ACTION: Proposed Rule; Request...

  15. CBLB502 administration protects gut mucosal tissue in ulcerative colitis by inhibiting inflammation

    PubMed Central

    Xu, Yang; Dong, Hongxia; Ge, Changhui; Gao, Yan; Liu, Haifeng

    2016-01-01

    Background Ulcerative colitis (UC) is a nonspecific inflammatory disease for which medications and therapeutic strategies have only been moderately successful. CBLB502, a toll-like receptor 5 (TLR5) agonist derived from Salmonella flagellin, exhibits anticancer and radioprotective activities via modulation of TLRs and the nuclear factor kappa B (NF-κB) signaling pathway and can protect against acute renal ischemic failure. In this study, we intend to examine the effects of CBLB502 on both TLR responses and the interleukin (IL) and NF-κB signaling pathways in UC treatment. Methods The UC mouse model was prepared in BALB/c mice by administering 2,4,6-trinitrobenzene sulfonic acid (TNBS). CBLB502 was used as the therapeutic drug. After CBLB502 therapy, the IL and tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Total RNA and protein of colon samples was extracted. Results We found that CBLB502 had a distinctive therapeutic effect in the UC model. In control group animals, IL-10 expression in serum was 91.48±24.38 ng/mL; this was higher than in the model group (59.36±14.46 ng/mL, P<0.05) or the treatment group (54.29±5.83 ng/mL, P<0.05). In model group animals, the concentration of TNF-α in serum was 140.11±12.70 ng/mL, which was lower than protein levels in the control group (173.86±29.26 ng/mL, P<0.05). The mRNA levels of TLR1, 2, 3, 4, 6, 7, 8, and 9 in the CBLB502 treatment group were significantly lower than in the model group (P<0.05). Western blot revealed that CBLB502 also reduced NF-κB expression in the mouse colon, but that NF-κB expression was not significantly lower than the model group. Conclusions CBLB502 can reduce mucosal damage induced by TNBS and inhibit inflammation and TLR expression. The inhibition of UC by CBLB502 is strictly TLR-IL-dependent and is dose-dependent within the efficacious dose range. Therefore, our results suggested that CBLB502 might be a candidate drug for the treatment of UC.

  16. CBLB502 administration protects gut mucosal tissue in ulcerative colitis by inhibiting inflammation

    PubMed Central

    Xu, Yang; Dong, Hongxia; Ge, Changhui; Gao, Yan; Liu, Haifeng

    2016-01-01

    Background Ulcerative colitis (UC) is a nonspecific inflammatory disease for which medications and therapeutic strategies have only been moderately successful. CBLB502, a toll-like receptor 5 (TLR5) agonist derived from Salmonella flagellin, exhibits anticancer and radioprotective activities via modulation of TLRs and the nuclear factor kappa B (NF-κB) signaling pathway and can protect against acute renal ischemic failure. In this study, we intend to examine the effects of CBLB502 on both TLR responses and the interleukin (IL) and NF-κB signaling pathways in UC treatment. Methods The UC mouse model was prepared in BALB/c mice by administering 2,4,6-trinitrobenzene sulfonic acid (TNBS). CBLB502 was used as the therapeutic drug. After CBLB502 therapy, the IL and tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Total RNA and protein of colon samples was extracted. Results We found that CBLB502 had a distinctive therapeutic effect in the UC model. In control group animals, IL-10 expression in serum was 91.48±24.38 ng/mL; this was higher than in the model group (59.36±14.46 ng/mL, P<0.05) or the treatment group (54.29±5.83 ng/mL, P<0.05). In model group animals, the concentration of TNF-α in serum was 140.11±12.70 ng/mL, which was lower than protein levels in the control group (173.86±29.26 ng/mL, P<0.05). The mRNA levels of TLR1, 2, 3, 4, 6, 7, 8, and 9 in the CBLB502 treatment group were significantly lower than in the model group (P<0.05). Western blot revealed that CBLB502 also reduced NF-κB expression in the mouse colon, but that NF-κB expression was not significantly lower than the model group. Conclusions CBLB502 can reduce mucosal damage induced by TNBS and inhibit inflammation and TLR expression. The inhibition of UC by CBLB502 is strictly TLR-IL-dependent and is dose-dependent within the efficacious dose range. Therefore, our results suggested that CBLB502 might be a candidate drug for the treatment of UC. PMID:27668221

  17. d-galactose administration induces memory loss and energy metabolism disturbance in mice: protective effects of catalpol.

    PubMed

    Zhang, Xiu-Li; An, Li-Jia; Bao, Yong-Ming; Wang, Jing-Yun; Jiang, Bo

    2008-08-01

    The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh rehmannia roots, on the behavior and brain energy metabolism in senescent mice induced by d-galactose were assessed. Except control group, mice were subcutaneously injected with d-galactose (150 mg/kg body weight) for 6 weeks. From the fifth week, drug group mice were treated with catalpol (2.5, 5, 10 mg/kg body weight) and piracetam (300 mg/kg body weight) for the last 2 weeks. Behavioral changes including open field test and passive avoidance were examined after drug administration. To determine the brain damage, pathological alterations were measured by hematoxylin and eosin (HE) staining. The activities of lactate dehydrogenase (LDH), glutathione S-transferase (GSH-ST), glutamine synthetase (GS), creatine kinase (CK) in brain cortex and hippocampus were determined using different biochemical methods. Consistent with the cognition deficits, the activities of GSH-ST, GS and CK decreased while the activity of LDH increased in aging mice brain. Administration of catalpol for 2-weeks not only ameliorated cognition deficit, but also reversed the biochemical markers mentioned above and reduced the histological lesions in mouse brain. These results suggest that catalpol has protective effects on memory damage and energy metabolism failure in aging model mice and is worth testing for further preclinical study aimed for senescence or neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD).

  18. Protection of Macrobrachium rosenbergii against white tail disease by oral administration of bacterial expressed and encapsulated double-stranded RNA.

    PubMed

    Naveen Kumar, Singaiah; Karunasagar, Indrani; Karunasagar, Iddya

    2013-09-01

    White tail disease (WTD) of cultured Macrobrachium rosenbergii is caused by M. rosenbergii nodavirus (MrNV) and an extra small virus (XSV), both present together, and the mortality rate can be as high as 100% within 2 or 3 days of infection. Possible protection of M. rosenbergii against WTD by oral administration of bacterial expressed and encapsulated double-stranded RNA (dsRNA) was studied. Juvenile M. rosenbergii were fed with the feed coated with inactivated bacteria encapsulated dsRNA of MrNV and XSV genes individually and in combination for 7 days followed by challenge with WTD causing agents at 24 h and 72 h post-feeding. Test animals fed with a combination of dsRNA of MrNV and XSV capsid genes showed the highest relative percent survival (RPS) when compared to other treatments with RPS of 80% and 75% at 24 and 72 h respectively. One hundred percent mortality was observed in test animals fed with control dsRNA coated feed. Although in the literature, injection is the most common method used to deliver dsRNA, this study shows that oral administration is effective, feasible and economical. PMID:23811407

  19. Protection of Macrobrachium rosenbergii against white tail disease by oral administration of bacterial expressed and encapsulated double-stranded RNA.

    PubMed

    Naveen Kumar, Singaiah; Karunasagar, Indrani; Karunasagar, Iddya

    2013-09-01

    White tail disease (WTD) of cultured Macrobrachium rosenbergii is caused by M. rosenbergii nodavirus (MrNV) and an extra small virus (XSV), both present together, and the mortality rate can be as high as 100% within 2 or 3 days of infection. Possible protection of M. rosenbergii against WTD by oral administration of bacterial expressed and encapsulated double-stranded RNA (dsRNA) was studied. Juvenile M. rosenbergii were fed with the feed coated with inactivated bacteria encapsulated dsRNA of MrNV and XSV genes individually and in combination for 7 days followed by challenge with WTD causing agents at 24 h and 72 h post-feeding. Test animals fed with a combination of dsRNA of MrNV and XSV capsid genes showed the highest relative percent survival (RPS) when compared to other treatments with RPS of 80% and 75% at 24 and 72 h respectively. One hundred percent mortality was observed in test animals fed with control dsRNA coated feed. Although in the literature, injection is the most common method used to deliver dsRNA, this study shows that oral administration is effective, feasible and economical.

  20. Protection against Flavobacterium psychrophilum infection (cold water disease) in Ayu fish (Plecoglossus altivelis) by oral administration of humus extract.

    PubMed

    NAKAGAWA, Jun; IWASAKI, Tadashi; KODAMA, Hiroshi

    2009-11-01

    Humic substances are formed during the decomposition of organic matter in humus, and are found in many natural environments in which organic materials and microorganisms have been present. In the present study, oral administration of humus extract to ayu fish (Plecoglossus altivelis) induced effective protection against experimental Flavobacterium psychrophilum infection (cold water disease). Mortality of fish and development of skin lesions, such as erosion and hemorrhages on the skin, gill cover or mouth, were significantly suppressed in fish treated with 10%, 5% or 1% humus extract adsorbed on dry pellets. Although F. psychrophilum was not re-isolated from gills and erosion lesions of the skin of dead fish, bacterial gyrB DNA could be amplified in these specimens from dead fish and surviving control fish using the polymerase chain reaction. The protective effect of the extract was not the results of direct killing of bacteria or antibiotic activity of the extract since no obvious reduction in the bacterial number was observed at 5 times to 5,000 times dilution of the humus extract having pH 5.45 to 7.40. These results clearly show that treating fish with humus extract is effective in preventing cold water disease.

  1. Detection of symmetry-protected topological order in AKLT states by exact evaluation of the strange correlator

    NASA Astrophysics Data System (ADS)

    Wierschem, K.; Beach, K. S. D.

    2016-06-01

    The strange correlator [Phys. Rev. Lett. 112, 247202 (2014), 10.1103/PhysRevLett.112.247202] has been proposed as a measure of symmetry protected topological order in one- and two-dimensional systems. It takes the form of a spin-spin correlation function, computed as a mixed overlap between the state of interest and a trivial local product state. We demonstrate that it can be computed exactly (asymptotically, in the Monte Carlo sense) for various Affleck-Kennedy-Lieb-Tasaki states by direct evaluation of the wave function within the valence bond loop gas framework. We present results for lattices with chain, square, honeycomb, cube, diamond, and hyperhoneycomb geometries. In each case, the spin quantum number S is varied such that 2 S (the number of valence bonds emerging from each site) achieves various integer multiples of the lattice coordination number. We introduce the concept of strange correlator loop winding number and point to its utility in testing for the presence of symmetry protected topological order.

  2. 40 CFR 178.70 - Administrative record.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Administrative record. 178.70 Section 178.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS... regulation or petition denial that was the subject of that order. (ii) The petition to which such...

  3. Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania.

    PubMed

    Valvassori, Samira S; Arent, Camila O; Steckert, Amanda V; Varela, Roger B; Jornada, Luciano K; Tonin, Paula T; Budni, Josiane; Mariot, Edemilson; Kapczinski, Flávio; Quevedo, João

    2015-08-01

    Several studies have suggested that alterations in brain-derived neurotrophic factor (BDNF) and increased oxidative stress have a central role in bipolar disorder (BD). Intracerebroventricular (ICV) injection of ouabain (OUA) in rats alters oxidative stress parameters and decreases BDNF levels in the brain. In this context, the present study aims to investigate the effects of BDNF ICV administration on BDNF levels and oxidative stress parameters in brains of rats submitted to animal model of mania induced by OUA. Wistar rats received an ICV injection of OUA, artificial cerebrospinal fluid (ACSF), OUA plus BDNF, or ACSF plus BDNF. Locomotor activity and risk-taking behavior in the rats were measured using the open-field test. In addition, we analyzed the BDNF levels and oxidative stress parameters (TBARS, Carbonyl, CAT, SOD, GR, and GPx) in the frontal cortex and hippocampus of rats. The BDNF was unable to reverse the ouabain-induced hyperactivity and risk-taking behavior. Nevertheless, BDNF treatment increased BDNF levels, modulated the antioxidant enzymes, and protected the OUA-induced oxidative damage in the brain of rats. These results suggest that BDNF alteration observed in BD patients may be associated with oxidative damage, both seen in this disorder. PMID:25164569

  4. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats

    PubMed Central

    Çiftçi, Osman; Otlu, Ali

    2016-01-01

    Introduction In the current study, the protective effect of hesperidin (HP) on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats was investigated. Material and methods Twenty-eight rats were divided equally into four groups. The first group was kept as a control and given only vehicle. In the second, rats were orally administered 50 mg/kg/day HP for 10 days. Carbon tetrachloride was given in a single intraperitoneal injection at the dose of 2 ml/kg in the third group. In the fourth group, the rats were treated with equal doses of CCl4 and HP. Results It was found that CCl4 induced oxidative stress via a significant increase in the formation of thiobarbituric acid-reactive substances (TBARS) and caused a significant decline in the levels of glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in rats. In contrast, HP blocked these toxic effects induced by CCl4, causing an increase in GSH, CAT and SOD levels and decreased formation of TBARS (p < 0.01). In addition, histopathological damage increased with CCl4 treatment. In contrast, HP treatment eliminated the effects of CCl4 and stimulated anti-apoptotic events, as characterized by reduced caspase-3 activation. Conclusions The current study demonstrated that CCl4-induced hepatotoxicity can be prevented with HP treatment. Thus, co-administration of HP with CCl4 may be useful for attenuating the negative effects of CCl4 on the liver. PMID:27279838

  5. Using AHP to analyze and ascertain the priority protective order of endangered plants in East Alashan-West Erdos

    NASA Astrophysics Data System (ADS)

    Tao, Zhang; Wei, Wang; Wang, Gary Z.; Luo, Hongyan; Liang, Cunzhu; Liu, Jiahui; An, Huijun; Pei, Hao; Zhong, Huidong; Chen, Xiaojun

    2006-08-01

    AHP is a kind of very effective systematic analytical method, widely applied to energy utilizing and resource analyzing, talent predicting, economic management project, urban industries planning, communications and transportation, water resource using and so on, using this method to solve the problem of ecology also have very strong practicability and validity. Using 15 kinds of endured plants in East Alashan-West Erdos as the research objects, this paper adopts 3S technique and outfield investigates to confirm the geographical distributions, extent density in the distribution area, plant community construction, and plant community environment of the plants. Then invite the experts to give marks according to this datum and using the AHP method to deal with the results, thereby get the priority protective order of endangered plants in East Alashan-West Erdos.

  6. 40 CFR 89.503 - Test orders.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Test orders. 89.503 Section 89.503... Test orders. (a) A test order addressed to the manufacturer is required for any testing under this subpart. (b) The test order is signed by the Assistant Administrator for Air and Radiation or his or...

  7. Passive administration of purified secretory IgA from human colostrum induces protection against Mycobacterium tuberculosis in a murine model of progressive pulmonary infection

    PubMed Central

    2013-01-01

    Background Immunoglobulin A is the most abundant isotype in secretions from mucosal surfaces of the gastrointestinal, respiratory and genitourinary tracts and in external secretions such as colostrum, breast milk, tears and saliva. The high concentration of human secretory IgA (hsIgA) in human colostrum strongly suggests that it should play an important role in the passive immune protection against gastrointestinal and respiratory infections. Materials and methods Human secretory IgA was purified from colostrum. The reactivity of hsIgA against mycobacterial antigens and its protective capacity against mycobacterial infection was evaluated. Results The passive administration of hsIgA reduces the pneumonic area before challenge with M. tuberculosis. The intratracheal administration of M. tuberculosis preincubated with hsIgA to mice greatly reduced the bacterial load in the lungs and diminished lung tissue injury. Conclusions HsIgA purified from colostrum protects against M. tuberculosis infection in an experimental mouse model. PMID:23458564

  8. Mental health, partner violence and HIV risk among women with protective orders against violent partners in Vhembe district, South Africa.

    PubMed

    Pengpid, Supa; Peltzer, Karl

    2013-12-01

    The aim of this study was to assess mental health, substance use and intimate partner violence in relation to Human Immunodeficiency Virus (HIV) risk in South Africa. In all 268 women (18 years and older) consecutively receiving a protection order in the Vhembe district in South Africa were assessed by an external interviewer. Results indicate that 69.8% of the women had never used a condom with their abusive partner and 16.4% had been diagnosed with a sexually transmitted infection (STI) in the past three months. A high proportion (51.9%) had Posttraumatic Stress Disorder (PTSD) and depression (66.4%). In multivariate analysis, being married or cohabiting, lower psychological abuse, higher physical violence and lower sexual violence, and having a PTSD was associated with never using a condom in the past 3 months; higher psychological abuse and higher physical and sexual violence were associated with a history of an STI in the past 3 months. Severity of physical and sexual intimate partner violence and suffering from PTSD increased HIV risk calling for multimodal interventions.

  9. Efficacy of polysaccharide from Alcaligenes xylosoxidans MSA3 administration as protection against γ-radiation in female rats

    PubMed Central

    Hassan, Amal I.; Ghoneim, Mona A. M.; Mahmoud, Manal G.; Asker, Mohsen M. S.; Mohamed, Saher S.

    2016-01-01

    Damage to normal tissues is a consequence of both therapeutic and accidental exposures to ionizing radiation. A water-soluble heteropolysaccharide called AXEPS, composed of glucose, galactose, rhamnose and glucouronic acid in a molar ratio of nearly 1.0:1.6:0.4:2.3, respectively, was isolated from culture medium of strain Alcaligenes xylosoxidans MSA3 by ethanol precipitation followed by freeze-drying. Chemical analysis, Fourier-transform infrared (FTIR) and chromatographic studies revealed that the molecular weight was 1.6 × 104 g mol−1. This study was designed to investigate the radioprotective and biological effects of AXEPS in alleviating the toxicity of ionizing radiation in female albino rats. A total of 32 female albino rats were divided into four groups. In the control group, rats were administered vehicle by tube for four weeks. The second group was administered AXEPS (100 mg/kg) orally by gavage for four weeks. Animals in the third group were exposed to whole-body γ-rays (5 Gy) and remained for 2 weeks without treatment. The fourth group received AXEPS (100 mg/kg) orally by gavage for two weeks before being exposed to whole-body γ-rays (5 Gy), then 24 h post γ-rays, they received AXEPS (100 mg/kg) in a treatment continuing till the end of the experiment (15 days after the whole–body γ-irradiation). Oral administration of AXEPS (100 mg/kg) significantly reversed the oxidative stress effects of radiation, as evidenced by the decrease in DNA damage in the bone marrow. Assessment of apoptosis and cell proliferation markers revealed that caspase-3 significantly increased in the irradiated group. Moreover, a significant decrease in the hematological constituents of peripheral blood, the chemotactic index and CD8+ T cells were observed in animals in the irradiation-only group, whereas an increase in the lymphocyte index was observed in animals in that group. In contrast, AXEPS treatment prevented these alterations. From our results, we conclude that

  10. Efficacy of polysaccharide from Alcaligenes xylosoxidans MSA3 administration as protection against γ-radiation in female rats.

    PubMed

    Hassan, Amal I; Ghoneim, Mona A M; Mahmoud, Manal G; Asker, Mohsen M S; Mohamed, Saher S

    2016-03-01

    Damage to normal tissues is a consequence of both therapeutic and accidental exposures to ionizing radiation. A water-soluble heteropolysaccharide called AXEPS, composed of glucose, galactose, rhamnose and glucouronic acid in a molar ratio of nearly 1.0:1.6:0.4:2.3, respectively, was isolated from culture medium of strain Alcaligenes xylosoxidans MSA3 by ethanol precipitation followed by freeze-drying. Chemical analysis, Fourier-transform infrared (FTIR) and chromatographic studies revealed that the molecular weight was 1.6 × 10(4) g mol(-1). This study was designed to investigate the radioprotective and biological effects of AXEPS in alleviating the toxicity of ionizing radiation in female albino rats. A total of 32 female albino rats were divided into four groups. In the control group, rats were administered vehicle by tube for four weeks. The second group was administered AXEPS (100 mg/kg) orally by gavage for four weeks. Animals in the third group were exposed to whole-body γ-rays (5 Gy) and remained for 2 weeks without treatment. The fourth group received AXEPS (100 mg/kg) orally by gavage for two weeks before being exposed to whole-body γ-rays (5 Gy), then 24 h post γ-rays, they received AXEPS (100 mg/kg) in a treatment continuing till the end of the experiment (15 days after the whole-body γ-irradiation). Oral administration of AXEPS (100 mg/kg) significantly reversed the oxidative stress effects of radiation, as evidenced by the decrease in DNA damage in the bone marrow. Assessment of apoptosis and cell proliferation markers revealed that caspase-3 significantly increased in the irradiated group. Moreover, a significant decrease in the hematological constituents of peripheral blood, the chemotactic index and CD8+ T cells were observed in animals in the irradiation-only group, whereas an increase in the lymphocyte index was observed in animals in that group. In contrast, AXEPS treatment prevented these alterations. From our results, we conclude that

  11. Efficacy of polysaccharide from Alcaligenes xylosoxidans MSA3 administration as protection against γ-radiation in female rats.

    PubMed

    Hassan, Amal I; Ghoneim, Mona A M; Mahmoud, Manal G; Asker, Mohsen M S; Mohamed, Saher S

    2016-03-01

    Damage to normal tissues is a consequence of both therapeutic and accidental exposures to ionizing radiation. A water-soluble heteropolysaccharide called AXEPS, composed of glucose, galactose, rhamnose and glucouronic acid in a molar ratio of nearly 1.0:1.6:0.4:2.3, respectively, was isolated from culture medium of strain Alcaligenes xylosoxidans MSA3 by ethanol precipitation followed by freeze-drying. Chemical analysis, Fourier-transform infrared (FTIR) and chromatographic studies revealed that the molecular weight was 1.6 × 10(4) g mol(-1). This study was designed to investigate the radioprotective and biological effects of AXEPS in alleviating the toxicity of ionizing radiation in female albino rats. A total of 32 female albino rats were divided into four groups. In the control group, rats were administered vehicle by tube for four weeks. The second group was administered AXEPS (100 mg/kg) orally by gavage for four weeks. Animals in the third group were exposed to whole-body γ-rays (5 Gy) and remained for 2 weeks without treatment. The fourth group received AXEPS (100 mg/kg) orally by gavage for two weeks before being exposed to whole-body γ-rays (5 Gy), then 24 h post γ-rays, they received AXEPS (100 mg/kg) in a treatment continuing till the end of the experiment (15 days after the whole-body γ-irradiation). Oral administration of AXEPS (100 mg/kg) significantly reversed the oxidative stress effects of radiation, as evidenced by the decrease in DNA damage in the bone marrow. Assessment of apoptosis and cell proliferation markers revealed that caspase-3 significantly increased in the irradiated group. Moreover, a significant decrease in the hematological constituents of peripheral blood, the chemotactic index and CD8+ T cells were observed in animals in the irradiation-only group, whereas an increase in the lymphocyte index was observed in animals in that group. In contrast, AXEPS treatment prevented these alterations. From our results, we conclude that

  12. The chicken or the egg? Systematic investigation of the effect of order of administration of Memory Questionnaires and Well-being Scales.

    PubMed

    Philippe, Frederick L; Bouizegarene, Nabil; Guilbault, Valérie; Rajotte, Guillaume; Houle, Iliane

    2015-01-01

    Narrative research claims that episodic/autobiographical memory characteristics and themes represent stable individual differences that relate to well-being. However, the effects of the order of administration of memory descriptions and well-being scales have never been investigated. Of importance, social cognitive research has shown that trivial contextual factors, such as completing a self-report measure, can influence the type of memories recollected afterwards and that memory recollection can transiently affect subsequent self-report ratings--both of which underscore that transient contextual effects, rather than stable individual differences in memory could be responsible for the correlation between memory characteristics and well-being. The present study examined if the order in which (positive or negative) memory and well-being scales are completed affects the characteristics and themes of the memory described, the scores of well-being reported and the relationship between the two. The results revealed some effects of order of administration when memories were described before completing well-being scales, but only on a situational measure of well-being, not on a trait measure. In sum, we recommend assessing memory-related material at the end of questionnaires to avoid potential mood-priming effects.

  13. Vaccination with liposomal leishmanial antigens adjuvanted with monophosphoryl lipid-trehalose dicorynomycolate (MPL-TDM) confers long-term protection against visceral leishmaniasis through a human administrable route.

    PubMed

    Ravindran, Rajesh; Maji, Mithun; Ali, Nahid

    2012-01-01

    The development of a long-term protective subunit vaccine against visceral leishmaniasis depends on antigens and adjuvants that can induce an appropriate immune response. The immunization of leishmanial antigens alone shows limited efficacy in the absence of an appropriate adjuvant. Earlier we demonstrated sustained protection against Leishmania donovani with leishmanial antigens entrapped in cationic liposomes through an intraperitoneal route. However, this route is not applicable for human administration. Herein, we therefore evaluated the immune response and protection induced by liposomal soluble leishmanial antigen (SLA) formulated with monophosphoryl lipid-trehalose dicorynomycolate (MPL-TDM) through a subcutaneous route. Subcutaneous immunization of BALB/c mice with SLA entrapped in liposomes or with MPL-TDM elicited partial protection against experimental visceral leishmaniasis. In contrast, liposomal SLA adjuvanted with MPL-TDM induced significantly higher levels of protection in liver and spleen in BALB/c mice challenged 10 days post-vaccination. Protection conferred by this formulation was sustained up to 12 weeks of immunization, and infection was controlled for at least 4 months of the challenge, similar to liposomal SLA immunization administered intraperitoneally. An analysis of cellular immune responses of liposomal SLA + MPL-TDM immunized mice demonstrated the induction of IFN-γ and IgG2a antibody production not only 10 days or 12 weeks post-vaccination but also 4 months after the challenge infection and a down regulation of IL-4 production after infection. Moreover, long-term immunity elicited by this formulation was associated with IFN-γ production also by CD8⁺ T cells. Taken together, our results suggest that liposomal SLA + MPL-TDM represent a good vaccine formulation for the induction of durable protection against L. donovani through a human administrable route.

  14. Oral Administration of Electron-Beam Inactivated Rhodococcus equi Failed to Protect Foals against Intrabronchial Infection with Live, Virulent R. equi.

    PubMed

    Rocha, Joana N; Cohen, Noah D; Bordin, Angela I; Brake, Courtney N; Giguère, Steeve; Coleman, Michelle C; Alaniz, Robert C; Lawhon, Sara D; Mwangi, Waithaka; Pillai, Suresh D

    2016-01-01

    There is currently no licensed vaccine that protects foals against Rhodococcus equi-induced pneumonia. Oral administration of live, virulent R. equi to neonatal foals has been demonstrated to protect against subsequent intrabronchial challenge with virulent R. equi. Electron beam (eBeam)-inactivated R. equi are structurally intact and have been demonstrated to be immunogenic when administered orally to neonatal foals. Thus, we investigated whether eBeam inactivated R. equi could protect foals against developing pneumonia after experimental infection with live, virulent R. equi. Foals (n = 8) were vaccinated by gavaging with eBeam-inactivated R. equi at ages 2, 7, and 14 days, or gavaged with equal volume of saline solution (n = 4), and subsequently infected intrabronchially with live, virulent R. equi at age 21 days. The proportion of vaccinated foals that developed pneumonia following challenge was similar among the vaccinated (7/8; 88%) and unvaccinated foals (3/4; 75%). This vaccination regimen did not appear to be strongly immunogenic in foals. Alternative dosing regimens or routes of administration need further investigation and may prove to be immunogenic and protective. PMID:26828865

  15. Oral Administration of Electron-Beam Inactivated Rhodococcus equi Failed to Protect Foals against Intrabronchial Infection with Live, Virulent R. equi

    PubMed Central

    Rocha, Joana N.; Cohen, Noah D.; Bordin, Angela I.; Brake, Courtney N.; Giguère, Steeve; Coleman, Michelle C.; Alaniz, Robert C.; Lawhon, Sara D.; Mwangi, Waithaka; Pillai, Suresh D.

    2016-01-01

    There is currently no licensed vaccine that protects foals against Rhodococcus equi–induced pneumonia. Oral administration of live, virulent R. equi to neonatal foals has been demonstrated to protect against subsequent intrabronchial challenge with virulent R. equi. Electron beam (eBeam)-inactivated R. equi are structurally intact and have been demonstrated to be immunogenic when administered orally to neonatal foals. Thus, we investigated whether eBeam inactivated R. equi could protect foals against developing pneumonia after experimental infection with live, virulent R. equi. Foals (n = 8) were vaccinated by gavaging with eBeam-inactivated R. equi at ages 2, 7, and 14 days, or gavaged with equal volume of saline solution (n = 4), and subsequently infected intrabronchially with live, virulent R. equi at age 21 days. The proportion of vaccinated foals that developed pneumonia following challenge was similar among the vaccinated (7/8; 88%) and unvaccinated foals (3/4; 75%). This vaccination regimen did not appear to be strongly immunogenic in foals. Alternative dosing regimens or routes of administration need further investigation and may prove to be immunogenic and protective. PMID:26828865

  16. 76 FR 3015 - Prohibitions in Areas Designated by Order; Closure of National Forest System Lands To Protect...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... National Forest System Lands To Protect Privacy of Tribal Activities AGENCY: Forest Service, USDA. ACTION... closure of National Forest System lands to protect the privacy of tribal activities for traditional and....'' FCEA authorizes the Secretary of Agriculture to ensure access to National Forest System lands, to...

  17. The effect of cortisol on emotional responses depends on order of cortisol and placebo administration in a within-subject design.

    PubMed

    Wirth, Michelle M; Scherer, Sean M; Hoks, Roxanne M; Abercrombie, Heather C

    2011-08-01

    Cortisol does not exhibit a straightforward relationship with mood states; administration of glucocorticoids to human subjects has produced mixed effects on mood and emotional processing. In this study, participants (N=46) received intravenous hydrocortisone (synthetic cortisol; 0.1mg/kg body weight) and placebo in randomized order over two sessions 48h apart. Following the infusion, participants rated neutral and unpleasant pictures. In Session 1, participants reported elevated negative affect (NA) following the picture-rating task, regardless of treatment. In Session 2, however, only participants who received cortisol (and thus who had received placebo in Session 1) reported elevated NA. Arousal ratings for unpleasant pictures followed a similar pattern. These findings suggest that the effects of cortisol on emotion vary based on situational factors, such as drug administration order or familiarity with the tasks and setting. Such factors can influence cortisol's effects on emotion in two ways: (A) cortisol may only potentiate NA and arousal ratings in the absence of other, overwhelming influences on affect, such as the novelty of the setting and tasks in Session 1; and (B) cortisol in Session 1 may facilitate learning processes (e.g., habituation to the stimuli and setting; extinction of aversive responses) such that emotional responses to the pictures are lessened in Session 2. This interpretation is compatible with a body of literature on the effects of glucocorticoids on learning and memory processes.

  18. The effect of cortisol on emotional responses depends on order of cortisol and placebo administration in a within-subjects design

    PubMed Central

    Wirth, Michelle M.; Scherer, Sean M.; Hoks, Roxanne M.; Abercrombie, Heather C.

    2010-01-01

    Cortisol does not exhibit a straightforward relationship with mood states; administration of glucocorticoids to human subjects has produced mixed effects on mood and emotional processing. In this study, participants (N=46) received intravenous hydrocortisone (synthetic cortisol; 0.1 mg/kg body weight) and placebo in randomized order over two sessions 48 hours apart. Following the infusion, participants rated neutral and unpleasant pictures. In Session 1, participants reported elevated negative affect (NA) following the picture-rating task, regardless of treatment. In Session 2, however, only participants who received cortisol (and thus who had received placebo in Session 1) reported elevated NA. Arousal ratings for unpleasant pictures followed a similar pattern. These findings suggest that the effects of cortisol on emotion vary based on situational factors, such as drug administration order or familiarity with the tasks and setting. Such factors can influence cortisol’s effects on emotion in two ways: A) cortisol may only potentiate NA and arousal ratings in the absence of other, overwhelming influences on affect, such as the novelty of the setting and tasks in Session 1; and B) cortisol in Session 1 may facilitate learning processes (e.g. habituation to the stimuli and setting; extinction of aversive responses) such that emotional responses to the pictures are lessened in Session 2. This interpretation is compatible with a body of literature on the effects of glucocorticoids on learning and memory processes. PMID:21232874

  19. Intranasal Administration of Mycobacterium bovis BCG Induces Superior Protection against Aerosol Infection with Mycobacterium tuberculosis in Mice

    PubMed Central

    Kolibab, Kristopher; Yang, Amy; Morris, Sheldon L.

    2014-01-01

    Despite the widespread use of Mycobacterium bovis BCG, the only licensed vaccine against tuberculosis (TB), TB remains a global epidemic. To assess whether more direct targeting of the lung mucosa by respiratory immunization would enhance the potency and longevity of BCG-induced anti-TB protective immunity, the long-term impact of intranasal (i.n.) BCG vaccination was compared to conventional subcutaneous (s.c.) immunization by using a mouse model of pulmonary tuberculosis. Although significantly improved protection in the lung was seen at early time points (2 and 4 months postvaccination) in i.n. BCG-immunized mice, no differences in pulmonary protection were seen 8 and 10 months postvaccination. In contrast, in all of the study periods, i.n. BCG vaccination induced significantly elevated protective splenic responses relative to s.c. immunization. At five of nine time points, we observed a splenic protective response exceeding 1.9 log10 protection relative to the s.c. route. Furthermore, higher frequencies of CD4 T cells expressing gamma interferon (IFN-γ) and IFN-γ/tumor necrosis factor alpha, as well as CD8 T cells expressing IFN-γ, were detected in the spleens of i.n. vaccinated mice. Using PCR arrays, significantly elevated levels of IFN-γ, interleukin-9 (IL-9), IL-11, and IL-21 expression were also seen in the spleen at 8 months after respiratory BCG immunization. Overall, while i.n. BCG vaccination provided short-term enhancement of protection in the lung relative to s.c. immunization, potent and extremely persistent splenic protective responses were seen for at least 10 months following respiratory immunization. PMID:25143340

  20. 40 CFR 90.503 - Test orders.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM NONROAD SPARK-IGNITION ENGINES AT OR BELOW 19 KILOWATTS Selective Enforcement Auditing § 90... Administrator shall not issue to a manufacturer more Selective Enforcement Auditing (SEA) test orders than...

  1. Acute but not chronic administration of pioglitazone promoted behavioral and neurochemical protective effects in the MPTP model of Parkinson's disease.

    PubMed

    Barbiero, Janaína K; Santiago, Ronise M; Lima, Marcelo M S; Ariza, Deborah; Morais, Lívia H; Andreatini, Roberto; Vital, Maria A B F

    2011-01-01

    The present study investigated the neurochemical, motor and cognitive effects of pioglitazone in a rat model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In the first experiment, we administered MPTP, and 1h later administered a single oral dose of pioglitazone (5, 15 and 30 mg/kg). The following day, we performed the open-field test and neurochemical dose response curve. We demonstrated that 30 mg/kg of pioglitazone was capable of restoring striatal dopamine (DA) concentrations and motor behaviors. A second experiment was conducted to test the effects of two protocols (acute and chronic) of pioglitazone (30 mg/kg) administration in the open-field test, two-way active avoidance task and in the DA and metabolites levels. The acute protocol consisted of a single oral administration 1 h after MPTP, whereas the chronic protocol was performed with daily administrations starting 1 h after MPTP and ending 22 days after that. Results showed that neither protocol was able to reverse the cognitive impairment promoted by MPTP. We also demonstrated that acute treatment generated some level of neuroprotection, as confirmed by the absence of DA reduction in the group treated with pioglitazone in comparison to the sham group. By contrast, chronic treatment leaded to a reduction of striatal DA, close to MPTP administration alone. These findings suggest that acute administration of pioglitazone (30 mg/kg) was more efficient in generating beneficial effects on motor behaviors and in striatal DA levels. Nevertheless, we failed to demonstrate that pioglitazone administration improved performance on a dopamine-related cognitive task after MPTP.

  2. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  3. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  4. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  5. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  6. 40 CFR 23.9 - Timing of Administrator's action under the Atomic Energy Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Timing of Administrator's action under the Atomic Energy Act. 23.9 Section 23.9 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Atomic Energy Act. Unless the Administrator otherwise explicitly provides in a particular order, the...

  7. Abrogation of attenuated lentivirus-induced protection in rhesus macaques by administration of depo-provera before intravaginal challenge with simian immunodeficiency virus mac239.

    PubMed

    Abel, Kristina; Rourke, Tracy; Lu, Ding; Bost, Kristen; McChesney, Michael B; Miller, Christopher J

    2004-11-01

    In nonhuman primate models of acquired immunodeficiency syndrome, live attenuated lentiviruses provide the most reliable protection from systemic and mucosal challenge with pathogenic simian immunodeficiency virus (SIV). Although live attenuated lentiviruses may never be used in humans because of safety concerns, understanding the nature of the protective immune mechanisms induced by live attenuated vaccines in primate models will be useful for developing other vaccine approaches. Approximately 60% of rhesus macaques immunized with nonpathogenic simian-human immunodeficiency virus (SHIV) strain 89.6 are protected from infection or clinical disease after intravaginal (IVAG) challenge with pathogenic SIVmac239. The goal of the present study was to determine whether administration of Depo-Provera before IVAG challenge with SIV decreases the protective efficacy of infection with SHIV89.6. The rate of protection after IVAG challenge with SIVmac239 was significantly lower (P<.05), and the acute postchallenge plasma viral RNA levels were significantly higher (P<.006), in Depo-Provera-treated, SHIV89.6-immunized macaques than in Depo-Provera-naive, SHIV89.6-immunized macaques. In the primate model of sexual transmission of human immunodeficiency virus, treatment with progesterone before IVAG challenge with a pathogenic virus can decrease the efficacy of a model "vaccine."

  8. 12 CFR 380.52 - Adequate protection.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Adequate protection. 380.52 Section 380.52... ORDERLY LIQUIDATION AUTHORITY Receivership Administrative Claims Process § 380.52 Adequate protection. (a... interest of a claimant, the receiver shall provide adequate protection by any of the following means:...

  9. 12 CFR 380.52 - Adequate protection.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Adequate protection. 380.52 Section 380.52... ORDERLY LIQUIDATION AUTHORITY Receivership Administrative Claims Process § 380.52 Adequate protection. (a... interest of a claimant, the receiver shall provide adequate protection by any of the following means:...

  10. 12 CFR 380.52 - Adequate protection.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Adequate protection. 380.52 Section 380.52... ORDERLY LIQUIDATION AUTHORITY Receivership Administrative Claims Process § 380.52 Adequate protection. (a... interest of a claimant, the receiver shall provide adequate protection by any of the following means:...

  11. A single intradermal administration of soluble leishmanial antigen and plasmid expressing interleukin-12 protects BALB/c mice from Leishmania major infection.

    PubMed

    Yamakami, K; Akao, S; Sato, M; Nitta, Y; Miyazaki, J; Tadakuma, T

    2001-07-01

    In murine leishmaniasis, the induction of the T-helper type 1 (Th1) response contributes to infection resistance, whereas the establishment of the Th2 response makes the mice susceptible to infection. Interleukin-12 (IL-12) plays a pivotal role in the diversification of immune responses to the Th1 type. In this study, we tested whether the co-administration of IL-12 expression plasmid which compose p35 and p40 subunits and soluble leishmanial antigen (SLA) will skew the susceptible BALB/c mice to Th1 response and protect from leishmaniasis. When the mice were intradermally injected with the combination of IL-12 plasmid and SLA 7 days prior to the challenge with 1x10(6) promastigotes of Leishmania major, the local lesions completely healed and the parasite burden in the local lymph nodes significantly decreased. The cured mice attained long-term immunity, and were resistant to any subsequent rechallenge of the lethal dose of the parasite. The protective effect was associated with the development of a Th1 response, as demonstrated by the enhanced level of antigen-specific interferon-gamma (IFN-gamma) and dominant production of IgG2a in the serum. In contrast, the administration of empty plasmid plus SLA or IL-12 plasmid alone failed to protect the disease and shape the Th1 response. Furthermore, the protective efficiency induced by the vaccination was clearly prevented by the injection of either neutralizing anti-IL-12 mAb or anti-IFN-gamma mAb. The IL-12 expression plasmid is thus an effective adjuvant for the elicitation of a protective Th1 response against leishmaniasis and is therefore, considered to be appropriate for vaccinations that require the induction of Th1 type immunity.

  12. Oral administration of a Spirulina extract enriched for Braun-type lipoproteins protects mice against influenza A (H1N1) virus infection.

    PubMed

    Pugh, Nirmal D; Edwall, Dan; Lindmark, Lars; Kousoulas, K Gus; Iyer, Arun V; Haron, Mona H; Pasco, David S

    2015-02-15

    A growing body of research indicates that oral administration of bacteria (such as probiotics) can exhibit a protective effect against influenza A (H1N1) viral infection in mice. In the present study, we used a mouse model to examine whether oral administration of Immulina(®), a commercial extract from the cyanobacteria Arthrospira (Spirulina) platensis, can reduce the severity of illness resulting from influenza A (H1N1) viral infection. The main active compounds within Immulina(®) are bacterial Braun-type lipoproteins that activate innate immune cells through a toll-like receptor (TLR) 2-dependent pathway. Mice that were fed Immulina(®) for 30 days before and 21 days after infection with influenza A (H1N1) virus exhibited a statistically significant reduction in the severity of infection. Compared to the control group, Immulina(®)-fed mice exhibited less weight loss, increased appetite, decreased clinical signs of disease, and lower lung histopathology scores. The results from the present study adds to the increasing evidence that oral administration of bacterial components that activate innate immune cells, whether derived from a bacterial preparation (probiotics or cyanobacteria) or from plant material containing endophytic bacteria, can exhibit a protective effect against influenza A (H1N1) viral infection. PMID:25765832

  13. The tumor protection effect of high-frequency administration of whole tumor cell vaccine and enhanced efficacy by the protein component from Agrocybe aegerita

    PubMed Central

    Liang, Yi; Sun, Hui

    2015-01-01

    Whole tumor cell vaccines have been widely studied and elicits limited immune responses because of the poor immunogenicity. In the present study, we discovered that high-frequency administration of irradiated whole tumor cell vaccine triggered rejection of tumor cells (90% or 100% of the mice that were vaccinated with irradiated H22 cells or S180 respectively were protected), and provided cross-protection and long-term anti-tumor immunity in BALB/c mouse models. The antitumor activity required CD4+, CD8+ T cells and macrophage that was proved in the nude mice and cell depletion mouse models. The adoptive transfer experiment suggested that repeated whole tumor cell vaccination successfully stimulated the anti-tumor response by activation of the immune cells. A high immunization frequency within a short period of time and the presence of glycosylated molecules and nucleic acids on the surface of intact tumor cells were crucial for the successful prevention of tumor growth by whole tumor cell vaccines. Moreover, Yt, the protein component from fungus Agrocybe aegerita, increased whole tumor cell vaccine-mediated tumor rejection and cross-protection effect. These data indicated that the frequency of administration of whole tumor cell vaccines was of critical importance for the efficacy, which needed to be integrated into vaccine strategies for producing potential vaccines. PMID:26221228

  14. Federal Administrative Law--Privacy, Freedom of Information and Protection of Human Subjects--Affecting Educational Research.

    ERIC Educational Resources Information Center

    Weinberger, JoAnn

    Since 1972, the issue of human rights protection has grown in complexity and intensity. Congress has passed four laws: Family Educational Rights and Privacy Act of 1974; Freedom of Information Act, as amended; Privacy Act of 1974; and National Research Act of 1974. From 1971-1980, the Department of Health, Education and Welfare (DHEW) and then the…

  15. Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2.

    PubMed

    Tao, Shasha; Park, Sophia L; Rojo de la Vega, Montserrat; Zhang, Donna D; Wondrak, Georg T

    2015-12-01

    Exposure to solar ultraviolet (UV) radiation is a causative factor in skin photodamage and carcinogenesis, and an urgent need exists for improved molecular photoprotective strategies different from (or synergistic with) photon absorption. Recent studies suggest a photoprotective role of cutaneous gene expression orchestrated by the transcription factor NRF2 (nuclear factor-E2-related factor 2). Here we have explored the molecular mechanism underlying carotenoid-based systemic skin photoprotection in SKH-1 mice and provide genetic evidence that photoprotection achieved by the FDA-approved apocarotenoid and food additive bixin depends on NRF2 activation. Bixin activates NRF2 through the critical Cys-151 sensor residue in KEAP1, orchestrating a broad cytoprotective response in cultured human keratinocytes as revealed by antioxidant gene expression array analysis. Following dose optimization studies for cutaneous NRF2 activation by systemic administration of bixin, feasibility of bixin-based suppression of acute cutaneous photodamage from solar UV exposure was investigated in Nrf2(+/+) versus Nrf2(-/-) SKH-1 mice. Systemic administration of bixin suppressed skin photodamage, attenuating epidermal oxidative DNA damage and inflammatory responses in Nrf2(+/+) but not in Nrf2(-/-) mice, confirming the NRF2-dependence of bixin-based cytoprotection. Taken together, these data demonstrate feasibility of achieving NRF2-dependent cutaneous photoprotection by systemic administration of the apocarotenoid bixin, a natural food additive consumed worldwide.

  16. 78 FR 40499 - Public Land Order No. 7818; Withdrawal of Public Lands for the Protection and Preservation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... Preservation of Solar Energy Zones for Future Energy Development; Arizona, California, Colorado, Nevada, New... laws, subject to valid existing rights, for a period of 20 years to protect 17 Solar Energy Zones (SEZ) for future solar energy development. The lands have been and will remain open to mineral...

  17. 7 CFR Exhibit C to Subpart G of... - Implementation Procedures for the Farmland Protection Policy Act; Executive Order 11988...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... base flood; and (g) Control soil erosion and sedimentation, e.g., construction of sediment basins... government, and private programs and policies to protect farmland. The Soil Conservation Service (SCS), as required by the Act, has promulgated implementation procedures for the Act at 7 CFR part 658 which...

  18. 7 CFR Exhibit C to Subpart G of... - Implementation Procedures for the Farmland Protection Policy Act; Executive Order 11988...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... base flood; and (g) Control soil erosion and sedimentation, e.g., construction of sediment basins... government, and private programs and policies to protect farmland. The Soil Conservation Service (SCS), as required by the Act, has promulgated implementation procedures for the Act at 7 CFR part 658 which...

  19. 7 CFR Exhibit C to Subpart G of... - Implementation Procedures for the Farmland Protection Policy Act; Executive Order 11988...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... base flood; and (g) Control soil erosion and sedimentation, e.g., construction of sediment basins... government, and private programs and policies to protect farmland. The Soil Conservation Service (SCS), as required by the Act, has promulgated implementation procedures for the Act at 7 CFR part 658 which...

  20. 7 CFR Exhibit C to Subpart G of... - Implementation Procedures for the Farmland Protection Policy Act; Executive Order 11988...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... base flood; and (g) Control soil erosion and sedimentation, e.g., construction of sediment basins... government, and private programs and policies to protect farmland. The Soil Conservation Service (SCS), as required by the Act, has promulgated implementation procedures for the Act at 7 CFR part 658 which...

  1. 7 CFR Exhibit C to Subpart G of... - Implementation Procedures for the Farmland Protection Policy Act; Executive Order 11988...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... base flood; and (g) Control soil erosion and sedimentation, e.g., construction of sediment basins... government, and private programs and policies to protect farmland. The Soil Conservation Service (SCS), as required by the Act, has promulgated implementation procedures for the Act at 7 CFR part 658 which...

  2. Protection of monkeys against Machupo virus by the passive administration of Bolivian haemorrhagic fever immunoglobulin (human origin).

    PubMed

    Eddy, G A; Wagner, F S; Scott, S K; Mahlandt, B J

    1975-01-01

    Bolivian haemorrhagic fever immunoglobulin of human origin, given either prior to or shortly after experimental infection with Machupo virus, protected rhesus and cynomolgus monkeys against initial clinical illness. Some survivors developed severe neurological signs 30-47 days after virus inoculation and died 4-6 days later. Results from one of the experiments suggested that the development of neurological signs was associated more frequently with high doses of immunoglobulin than with intermediate or low doses.

  3. 5 CFR 1201.74 - Orders for discovery.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1201.74 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES... administrative judge may deny a motion to compel discovery if a party fails to comply with the requirements of 5 CFR § 1201.73(e)(1) and (f)(4). (b) Content of order. Any order issued will include, where...

  4. Outcomes of custody and visitation petitions when fathers are restrained by protection orders: the case of the New York family courts.

    PubMed

    Rosen, Leora N; O'Sullivan, Chris S

    2005-08-01

    A random sample of custody and visitation petitions filed in New York City Family Courts in 1995 was used to examine outcomes of mothers' Order of Protection (OP) Petitions in relation to parents' custody and visitation petitions. Fathers restrained by OPs were more likely to secure visitation orders (64%) than not. In contrast, 80.8% of fathers' custody petitions were dismissed when they were restrained by OPs. Fathers' custody petitions were most likely to be ordered when mothers' OP petitions were withdrawn. Mothers were most likely to secure custody when their OP petitions were ordered or withdrawn. Courts rarely denied petitions. Those that did not result in court orders were either withdrawn by the petitioner or dismissed by the court (most likely because of failure of the petitioner to appear in court). This pattern has negative implications for battered women who may be vulnerable to pressure or threats from abusive ex-partners.

  5. Order Up

    ERIC Educational Resources Information Center

    Gibeault, Michael

    2005-01-01

    Change orders. The words can turn the stomachs of administrators. Horror stories about change orders create fear and distrust among school officials, designers and builders. Can change orders be avoided? If car manufacturers can produce millions of intricately designed vehicles, why can't the same quality control be achieved on a construction…

  6. Sublingual administration of bacteria-expressed influenza virus hemagglutinin 1 (HA1) induces protection against infection with 2009 pandemic H1N1 influenza virus.

    PubMed

    Shim, Byoung-Shik; Choi, Jung-Ah; Song, Ho-Hyun; Park, Sung-Moo; Cheon, In Su; Jang, Ji-Eun; Woo, Sun Je; Cho, Chung Hwan; Song, Min-Suk; Kim, Hyemi; Song, Kyung Joo; Lee, Jae Myun; Kim, Suhng Wook; Song, Dae Sub; Choi, Young Ki; Kim, Jae-Ouk; Nguyen, Huan Huu; Kim, Dong Wook; Bahk, Young Yil; Yun, Cheol-Heui; Song, Man Ki

    2013-02-01

    Influenza viruses are respiratory pathogens that continue to pose a significantly high risk of morbidity and mortality of humans worldwide. Vaccination is one of the most effective strategies for minimizing damages by influenza outbreaks. In addition, rapid development and production of efficient vaccine with convenient administration is required in case of influenza pandemic. In this study, we generated recombinant influenza virus hemagglutinin protein 1 (sHA1) of 2009 pandemic influenza virus as a vaccine candidate using a well-established bacterial expression system and administered it into mice via sublingual (s.l.) route. We found that s.l. immunization with the recombinant sHA1 plus cholera toxin (CT) induced mucosal antibodies as well as systemic antibodies including neutralizing Abs and provided complete protection against infection with pandemic influenza virus A/CA/04/09 (H1N1) in mice. Indeed, the protection efficacy was comparable with that induced by intramuscular (i.m.) immunization route utilized as general administration route of influenza vaccine. These results suggest that s.l. vaccination with the recombinant non-glycosylated HA1 protein offers an alternative strategy to control influenza outbreaks including pandemics. PMID:23456722

  7. Acute Coronary Syndromes, Gastrointestinal Protection, and Recommendations Regarding Concomitant Administration of Proton-Pump Inhibitors (Omeprazol/Esomeprazole) and Clopidogrel.

    PubMed

    Lozano, Iñigo; Sanchez-Insa, Esther; de Leiras, Sergio Rodríguez; Carrillo, Pilar; Ruiz-Quevedo, Valeriano; Pinar, Eduardo; Gopar-Gopar, Silvia; Bayon, Jeremías; Mañas, Pilar; Lasa, Garikoitz; CruzGonzalez, Ignacio; Hernandez, Felipe; Fernandez-Portales, Javier; Fernandez-Fernandez, Javier; Pérez-Serradilla, Ana; de la Torre Hernandez, José M; Gomez-Jaume, Alfredo

    2016-02-01

    The Food and Drug Administration and the European Medicines Agency sent a warning in 2010 discouraging the concomitant use of clopidogrel with omeprazole or esomeprazole. The purpose is to know the gastroprotective approach in patients with acute coronary syndrome (ACS) and the level of follow-up of the alert. In 17 hospitals with catheterization laboratory in Spain, 1 per region, we studied 25 consecutive patients per hospital whose diagnosis of discharge since October 1, 2013, had been any type of ACS. We analyzed their baseline clinical profile, the gatroprotective agents at admission and discharge and the antiplatelet therapy at discharge. The number of patients included was 425: age 67.2 ± 12.5 years, women 29.8%, diabetes 36.5%. The patients presented unstable angina in 21.6%, non-ST-elevation myocardial infarction in 35.3% and ST-elevation myocardial infarction in 43.1%. Conservative approach was chosen in 17.9%, bare-metal stents 32.2%, ≥ 1 drug-eluting stent 48.5%, and surgery 1.4%. Aspirin was indicated in 1.9%, aspirin + clopidogrel 73.6%, aspirin + prasugrel 17.6%, and aspririn + ticagrelor 6.8%. Gastroprotective agents were present in 40.2% patients at admission and this percentage increased to 93.7% at discharge. Of the 313 (73.6%) on clopidogrel in 96 (30.6%) was combined with omeprazole and 3 (0.95%) with esomeprazole, whereas the most commonly used was pantoprazole with 190 patients (44.7%). In conclusion, almost the totality of the patients with an ACS receive gastroprotective agents at the moment of discharge, most of them with proton-pump inhibitors. In one every 3 cases of the patients who are on clopidogrel, the recommendation of the Food and Drug Administration and the European Medicines Agency is not followed.

  8. Chronic administration of Liu Wei Dihuang protects rat's brain against D-galactose-induced impairment of cholinergic system.

    PubMed

    Zhang, Wei-Wei; Sun, Qi-Xin; Liu, Yin-Hui; Gao, Wei; Li, Yan-Hai; Lu, Kun; Wang, Zhuo

    2011-06-25

    This study was aimed to investigate the protective effect of Liu Wei Dihuang (LWDH) against D-galactose (D-gal)-induced brain injury in rats and the existence of sex-dependent differences in LWDH protection. Sixty-four rats evenly composed of males and females were randomly assigned into 4 groups (n = 8): normal saline (NS) + NS (N + N), NS + LWDH (N + L), D-gal + NS (D + N) and D-gal + LWDH (D + L) groups. Rats in D + N and D + L groups received daily injection of D-gal (100 mg/kg, s.c.) for six weeks to establish the aging model, while rats in N + N and N + L groups were injected with the same volume of NS. From the third week, rats in N + L and D + L groups were orally administered with a decoction of LWDH for subsequent six weeks. Rats in N + N and D + N groups were orally administered just with the same volume of NS simultaneously. Morris water maze test was employed to evaluate the ability of learning and memory of the rats in all the groups. Acetylcholine (ACh) content, activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in visual cortex were assayed. Hematoxylin and eosin (HE) staining were used to observe the morphologic injury in hippocampus and visual cortex, and immunohistochemistry was performed to evaluate ChAT and AChE expression levels in the visual cortex. The results showed that the rats in D + N groups exhibited a longer escape latency to platform, lower swimming speed, less percent of target quadrant search time and platform crossings, compared with N + N groups, suggesting the establishment of aging model, while LWDH improved these indexes in D-gal-treated rats. Compared with D + N groups, LWDH increased ACh content and ChAT activity, and decreased AChE activity in visual cortex. Remarkable loss of neurons was found in hippocampus and visual cortex of aging rats, and the injury was significantly attenuated by LWDH. Immunohistochemistry showed D-gal-induced decreases of ChAT and AChE expressions were restored by LWDH

  9. [Order of 10 September 1992 on the possession, distribution, dispensing, and administration of the pharmaceutical speciality Mifegyne 200 mg. in tablet form].

    PubMed

    1992-09-20

    This Order sets forth rules on the proper management of Mifegyne (RU 486) in France. Under its first section, manufacturers and distributors are required to keep the drug in a locked cabinet and maintain detailed records of the amounts manufactured and the persons who have sold and bought the drug. Under its second section, the purchase, dispensing, and administration of the drug are restricted to public-sector health establishments and private-sector health establishments authorized under Article L. 176 of the Public Health Code. Such establishments must be authorized to perform voluntary terminations of pregnancy and must own a pharmacy that has been opened under the conditions set forth in Article L. 577 of the Public Health Code and is operated by a pharmacist registered under section D, E, or F of the Public Health Code. The drug must be kept in a locked cabinet by the pharmacy, except for the amounts used weekly, which can be kept under lock in the department where they are used; records must be maintained of purchases and distributions of the drug and of its use, including the signature of any woman desiring to use the drug to terminate her pregnancy; and only specially authorized physicians can prescribe or administer the drug. An Order of 25 November 1992 establishes an automated processing system to enable information to be provided to Parliament on the sociodemographic aspects of voluntary termination of pregnancy and to give the Government, within the framework of its public health policy, the means of elucidating the medical and social reality of this procedure. See Journal Officiel de la Republique Francaise, No. 283, 5 December 1992, p. 16666, as summarized in International Digest of Health Legislation, Vol. 44, No. 2, 1993, p. 351.

  10. Administration of low dose estrogen attenuates gliosis and protects neurons in acute spinal cord injury in rats.

    PubMed

    Samantaray, Supriti; Das, Arabinda; Matzelle, Denise C; Yu, Shan P; Wei, Ling; Varma, Abhay; Ray, Swapan K; Banik, Naren L

    2016-03-01

    Spinal cord injury (SCI) is a debilitating condition with neurological deficits and loss of motor function that, depending on the severity, may lead to paralysis. The only treatment currently available is methylprednisolone, which is widely used and renders limited efficacy in SCI. Therefore, other therapeutic agents must be developed. The neuroprotective efficacy of estrogen in SCI was studied with a pre-clinical and pro-translational perspective. Acute SCI was induced in rats that were treated with low doses of estrogen (1, 5, 10, or 100 μg/kg) and compared with vehicle-treated injured rats or laminectomy control (sham) rats at 48 h post-SCI. Changes in gliosis and other pro-inflammatory responses, expression and activity of proteolytic enzymes (e.g., calpain, caspase-3), apoptosis of neurons in SCI, and cell death were monitored via Western blotting and immunohistochemistry. Negligible pro-inflammatory responses or proteolytic events and very low levels of neuronal death were found in sham rats. In contrast, vehicle-treated SCI rats showed profound pro-inflammatory responses with reactive gliosis, elevated expression and activity of calpain and caspase-3, elevated Bax:Bcl-2 ratio, and high levels of neuronal death in lesion and caudal regions of the injured spinal cord. Estrogen treatment at each dose reduced pro-inflammatory and proteolytic activities and protected neurons in the caudal penumbra in acute SCI. Estrogen treatment at 10 μg was found to be as effective as 100 μg in ameliorating the above parameters in injured animals. Results from this investigation indicated that estrogen at a low dose could be a promising therapeutic agent for treating acute SCI. Experimental studies with low dose estrogen therapy in acute spinal cord injury (SCI) demonstrated the potential for multi-active beneficial outcomes. Estrogen has been found to ameliorate several degenerative pathways following SCI. Thus, such early protective effects may even lead to functional

  11. Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress.

    PubMed

    Campbell, Adam M; Park, Collin R; Zoladz, Phillip R; Muñoz, Carmen; Fleshner, Monika; Diamond, David M

    2008-02-01

    Extensive research has shown that the antidepressant tianeptine blocks the adverse effects of chronic stress on hippocampal functioning. The current series of experiments extended this area of investigation by examining the influence of tianeptine on acute stress-induced impairments of spatial (hippocampus-dependent) memory. Tianeptine (10 mg/kg, ip) administered to adult male rats before, but not after, water maze training blocked the amnestic effects of predator stress (occurring between training and retrieval) on memory. The protective effects of tianeptine on memory occurred in rats which had extensive pre-stress training, as well as in rats which had only a single day of training. Tianeptine blocked stress effects on memory without altering the stress-induced increase in corticosterone levels. Propranolol, a beta-adrenergic receptor antagonist (5 and 10 mg/kg, ip), in contrast, did not block stress-induced amnesia. These findings indicate that treatment with tianeptine, unlike propanolol, provides an effective means with which to block the adverse effects of stress on cognitive functions of the hippocampus.

  12. Protection against bovine tuberculosis induced by oral vaccination of cattle with Mycobacterium bovis BCG is not enhanced by co-administration of mycobacterial protein vaccines.

    PubMed

    Wedlock, D Neil; Aldwell, Frank E; Vordermeier, H Martin; Hewinson, R Glyn; Buddle, Bryce M

    2011-12-15

    Mycobacterium bovis bacille Calmette-Guérin (BCG) delivered to calves by the oral route in a formulated lipid matrix has been previously shown to induce protection against bovine tuberculosis. A study was conducted in cattle to determine if a combination of a low dose of oral BCG and a protein vaccine could induce protective immunity to tuberculosis while not sensitising animals to tuberculin. Groups of calves (10 per group) were vaccinated by administering 2 × 10(7)colony forming units (CFU) of BCG orally or a combination of 2 × 10(7)CFU oral BCG and a protein vaccine comprised of M. bovis culture filtrate proteins (CFP) formulated with the adjuvants Chitin and Gel 01 and delivered by the intranasal route, or CFP formulated with Emulsigen and the TLR2 agonist Pam(3)CSK(4) and administered by the subcutaneous (s.c.) route. Two further groups were vaccinated with the CFP/Chitin/Gel 01 or CFP/Emulsigen/Pam(3)CSK(4) vaccines alone. Positive control groups were given 10(8)CFU oral BCG or 10(6)CFU s.c. BCG while a negative control group was non-vaccinated. All animals were challenged with M. bovis 15 weeks after vaccination and euthanized and necropsied at 16 weeks following challenge. Groups of cattle vaccinated with s.c. BCG, 10(8)CFU or 2 × 10(7)CFU oral BCG showed significant reductions in seven, three and four pathological or microbiological disease parameters, respectively, compared to the results for the non-vaccinated group. There was no evidence of protection in calves vaccinated with the combination of oral BCG and CFP/Emulsigen/Pam(3)CSK(4) or oral BCG and CFP/Chitin/Gel 01 or vaccinated with the protein vaccines alone. Positive responses in the comparative cervical skin test at 12 weeks after vaccination were only observed in animals vaccinated with s.c. BCG, 10(8)CFU oral BCG or a combination of 2 × 10(7)CFU oral BCG and CFP/Chitin/Gel 01. In conclusion, co-administration of a protein vaccine, administered by either systemic or mucosal routes with oral

  13. Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice.

    PubMed

    Bao, Lihua; Haas, Mark; Kraus, Damian M; Hack, Bradley K; Rakstang, Jonathan K; Holers, V Michael; Quigg, Richard J

    2003-03-01

    Complement receptor 1-related gene/protein y (Crry) in rodents is a potent membrane complement regulator that inhibits complement C3 activation by both classical and alternative pathways. To clarify the role of complement in lupus nephritis, MRL/lpr mice were given Crry as a recombinant protein (Crry-Ig) from 12 to 24 wk of age. Control groups were given saline or normal mouse IgG. Sera and urine were collected biweekly. Only 1 of 20 (5%) Crry-Ig-treated mice developed renal failure (BUN > 50 mg/dl) compared with 18 of 38 (47.4%) mice in control groups (P = 0.001). BUN levels at 24 wk were reduced from 68.8 +/- 9.7 mg/dl in control groups to 38.5 +/- 3.9 mg/dl in the Crry-Ig-treated group (P < 0.01). Urinary albumin excretion at 24 wk was also significantly reduced from 5.3 +/- 1.4 mg/mg creatinine in the control groups to 0.5 +/- 0.2 mg/mg creatinine in the Crry-Ig-treated group (P < 0.05). Of the histologic data at 24 wk, there was a significant reduction in scores for glomerulosclerosis and C3d, IgG, IgG3, and IgA staining intensity in glomeruli in complement-inhibited animals. Crry-Ig-treated animals were also protected from vasculitic lesions. Although there was no effect on relevant autoimmune manifestations such as anti-double stranded DNA titers or cryoglobulin IgG3 levels, circulating immune complex levels were markedly higher in complement-inhibited animals. Thus, inhibition of complement activation with Crry-Ig significantly reduces renal disease in MRL/lpr lupus mice. The data support the strategy of using recombinant complement C3 inhibitors to treat human lupus nephritis.

  14. Hibiscus sabdariffa ethanolic extract protects against dyslipidemia and oxidative stress induced by chronic cholesterol administration in rabbits.

    PubMed

    Ekor, M; Adesanoye, O A; Udo, I E; Adegoke, O A; Raji, J; Farombi, E O

    2010-12-01

    Excessive intake of cholesterol (CHOL) and induction of free radical production play a critical role in the pathophysiology of several human diseases. Dietary therapy with plant products rich in flavonoids has been shown to provide benefits without the adverse effects of agents used in clinical practice. Hibiscus sabdariffa (HS) has been used for various purposes due to myriads of flavonoids present in it. In this study, the chemopreventive property of HS ethanolic extract (HSE) was investigated in dyslipidemia and oxidant stress associated with prolonged CHOL administration in rabbits. Twenty-five (25) adult male rabbits weighing between 1.5 and 1.7 kg were used and randomly divided into five groups of five rabbits per group. The CHOL-fed rabbits received 1 g/kg/day of CHOL suspended in 1 ml of corn oil for 8 weeks. Group 1 received 1 ml of corn oil and served as control. Group 2 was fed with CHOL only while groups 3, 4 and 5 received daily doses ofcholestyramine (questran, 260 mg/kg), HSE 200 mg/kg and HSE 300 mg/kg respectively along with CHOL. Animals were sacrificed by cervical dislocation 24-hours after last dose. Enzymic and non-enzymic markers of oxidative stress and lipid profile were analysed in serum, liver, kidney and heart of rabbits. HSE significantly attenuated the alteration in lipid levels and antioxidant status induced by high CHOL intake in rabbits in this study. Both serum and tissue levels of low density lipoprotein-CHOL, triglycerides, phospholipids, and total CHOL decreased with increase in high density lipoprotein-CHOL except in the heart, following treatment with HSE in CHOL-fed rabbits when compared with the untreated group (p<0.05). Similarly, HSE prevented CHOL-induced depletion of enzymic (superoxide dismutase, catalase) and non-enzymic (reduced glutathione, vitamin C) antioxidants with the attendant increases in lipid peroxidation and xanthine oxidase activity in these animals. The effectiveness of HSE in this condition was comparable

  15. Abused women with children who are first-time users of a shelter or applicants for a protection order: entry data of a 7-year prospective analysis.

    PubMed

    McFarlane, Judith; Maddoux, John; Nava, Angeles; Gilroy, Heidi

    2015-02-01

    Worldwide, two models of care are offered most often to abused women-safe shelter and justice services. No evidence exists on the differential effectiveness of the services. To provide evidence, 300 abused women, 150 first-time users of a shelter and 150 first-time applicants for a protection order, signed informed consent to participate in a 7-year study. Safety, abuse, and functioning of the women and their children were measured. Compared with women seeking justice services, women in shelters reported more abuse and depression and less support. The baseline characteristics of these 300 women are presented with implications for practice and policy.

  16. DEPRESSIVE AND POSTTRAUMATIC SYMPTOMS AMONG WOMEN SEEKING PROTECTION ORDERS AGAINST INTIMATE PARTNERS: RELATIONS TO COPING STRATEGIES AND PERCEIVED RESPONSES TO ABUSE DISCLOSURE

    PubMed Central

    Flicker, Sharon M.; Cerulli, Catherine; Swogger, Marc T.; Talbot, Nancy L.

    2014-01-01

    This investigation examined the relationship of abuse-specific coping strategies and perceived responses to abuse disclosure to symptoms of depression and posttraumatic stress among 131 women seeking a protection order against an intimate partner. Disengagement, denial, and self-blame coping strategies, as well as blaming of the participant by others, were associated with greater depressive and posttraumatic symptoms. None of the strategies of coping or responses to abuse disclosure were negatively related to depressive or posttraumatic stress symptoms. Findings suggest that mental health providers may find it useful to address these negative styles of coping while public education campaigns should target victim-blaming. PMID:22735315

  17. 40 CFR 86.603-88 - Test orders.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Test orders. 86.603-88 Section 86.603... New Light-Duty Vehicles, Light-Duty Trucks, and Heavy-Duty Vehicles § 86.603-88 Test orders. (a) The Administrator will require any testing under this subpart by means of a test order addressed to the...

  18. 40 CFR 86.603-88 - Test orders.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 20 2012-07-01 2012-07-01 false Test orders. 86.603-88 Section 86.603... Auditing of New Light-Duty Vehicles, Light-Duty Trucks, and Heavy-Duty Vehicles § 86.603-88 Test orders. (a) The Administrator will require any testing under this subpart by means of a test order addressed...

  19. Administration of thimerosal to infant rats increases overflow of glutamate and aspartate in the prefrontal cortex: protective role of dehydroepiandrosterone sulfate.

    PubMed

    Duszczyk-Budhathoki, Michalina; Olczak, Mieszko; Lehner, Malgorzata; Majewska, Maria Dorota

    2012-02-01

    Thimerosal, a mercury-containing vaccine preservative, is a suspected factor in the etiology of neurodevelopmental disorders. We previously showed that its administration to infant rats causes behavioral, neurochemical and neuropathological abnormalities similar to those present in autism. Here we examined, using microdialysis, the effect of thimerosal on extracellular levels of neuroactive amino acids in the rat prefrontal cortex (PFC). Thimerosal administration (4 injections, i.m., 240 μg Hg/kg on postnatal days 7, 9, 11, 15) induced lasting changes in amino acid overflow: an increase of glutamate and aspartate accompanied by a decrease of glycine and alanine; measured 10-14 weeks after the injections. Four injections of thimerosal at a dose of 12.5 μg Hg/kg did not alter glutamate and aspartate concentrations at microdialysis time (but based on thimerosal pharmacokinetics, could have been effective soon after its injection). Application of thimerosal to the PFC in perfusion fluid evoked a rapid increase of glutamate overflow. Coadministration of the neurosteroid, dehydroepiandrosterone sulfate (DHEAS; 80 mg/kg; i.p.) prevented the thimerosal effect on glutamate and aspartate; the steroid alone had no influence on these amino acids. Coapplication of DHEAS with thimerosal in perfusion fluid also blocked the acute action of thimerosal on glutamate. In contrast, DHEAS alone reduced overflow of glycine and alanine, somewhat potentiating the thimerosal effect on these amino acids. Since excessive accumulation of extracellular glutamate is linked with excitotoxicity, our data imply that neonatal exposure to thimerosal-containing vaccines might induce excitotoxic brain injuries, leading to neurodevelopmental disorders. DHEAS may partially protect against mercurials-induced neurotoxicity. PMID:22015977

  20. Early administration of nifedipine protects against angiotensin II-induced cardiomyocyte hypertrophy through regulating CaMKII-SERCA2a pathway and apoptosis in rat cardiomyocytes.

    PubMed

    Luo, Ji; Zhang, Wei-dong; Du, Yi-meng

    2016-04-01

    The calcium channel blocker (CCB), nifedipine, is a more effective treatment for early- than late-stage cardiac hypertrophy. We investigated the effects of early- and late-stage nifedipine administration on calcium homeostasis, CaMKII (Ca(2+) /calmodulin-dependent protein kinase II) activity and apoptosis of cardiomyocytes under hypertrophic stimulation with angiotensin II (AngII). Primary rat cardiomyocytes were divided into five treatment groups: AK, AngII plus the CaMKII inhibitor, KN-93; AN-1 (early-stage), AngII plus nifedipine × 48 h; AN-2 (late-stage), AngII × 48 h, then AngII plus nifedipine × 48 h; C, untreated; and A, AngII × 48 h. The t1/2β [time required for intracellular Ca(2+) concentration ([Ca(2+) ]i) to decline to one half of the peak value] decreased; however, CaMKII and SERCA2a (sarcoplasmic reticulum Ca(2+) -ATPase 2a) activities increased in the AN-1 group compared with the AK group. In the AN-2 group compared with the AN-1 group, CaMKII activity, t1/2α [time required for [Ca(2+) ]i to increase from the bottom to one half of peak value], t1/2β, and apoptosis increased. These results indicate that the timing of CCB administration affects the calcium concentration and apoptosis of hypertrophic cardiomyocytes through the CaMKII-SERCA2a signalling pathway, thereby influencing the drug's protective activity against cardiomyocyte hypertrophy. PMID:26968727

  1. Gastrointestinal protective efficacy of Kolaviron (a bi-flavonoid from Garcinia kola) following a single administration of sodium arsenite in rats: Biochemical and histopathological studies

    PubMed Central

    Akinrinde, Akinleye S.; Olowu, Ebunoluwa; Oyagbemi, Ademola A.; Omobowale, Olutayo T.

    2015-01-01

    Background: Arsenic intoxication is known to produce symptoms including diarrhea and vomiting, which are indications of gastrointestinal dysfunction. Objective: We investigated whether Kolaviron (KV) administration protected against sodium arsenite (NaAsO2)-induced damage to gastric and intestinal epithelium in rats. Materials and Methods: Control rats (Group I) were given a daily oral dose of corn oil. Rats in other groups were given a single dose of NaAsO2 (100 mg/kg; intraperitoneal) alone (Group II) or after pretreatment for 7 days with KV at 100 mg/kg (Group III) and 200 mg/kg (Group IV). Rats were sacrificed afterward and portions of the stomach, small intestine and colon were processed for histopathological examination. Hydrogen peroxide, reduced glutathione, malondialdehyde (MDA) concentrations as well as activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST) and myeloperoxidase (MPO) were measured in the remaining portions of the different gastrointestinal tract (GIT) segments. Results: NaAsO2 caused significant increases (P < 0.05) in MDA levels and MPO activity, with significant reductions (P < 0.05) in GST, GPX, CAT and SOD activities in the stomach and intestines. KV significantly reversed the changes (P < 0.05) in a largely dose-dependent manner. The different segments had marked inflammatory cellular infiltration, with hyperplasia of the crypts, which occurred to much lesser degrees with KV administration. Conclusion: The present findings showed that KV might be a potent product for mitigating NaAsO2 toxicity in the GIT. PMID:26130939

  2. Environmental enrichment protects against the acquisition of cocaine self-administration in adult male rats, but does not eliminate avoidance of a drug-associated saccharin cue.

    PubMed

    Puhl, Matthew D; Blum, Joshua S; Acosta-Torres, Stefany; Grigson, Patricia S

    2012-02-01

    One of the most menacing consequences of drug addiction is the devaluation of natural rewards (e.g. food, sex, work, money, caring for one's offspring). However, evidence also suggests that natural rewards, such as an enriched environment, can devalue drugs of abuse. Thus, this study used a rodent model to test whether exposure to an enriched environment could protect adult rats from acquiring cocaine self-administration and from the resultant drug-induced devaluation of a natural saccharin reward cue. Adult male Sprague-Dawley rats were implanted with intravenous jugular catheters. Rats were then separated into two housing conditions: an enriched condition, including social companions(four/cage) and novel objects (e.g. balls, polyethylene tubes, paper, etc.), and a nonenriched condition where the rats were singly housed with no novel objects. During testing, the rats were given 5-min access to 0.15% saccharin, followed by 1 h to self-administer saline or cocaine (0.167 mg/infusion) on fixed ratio and progressive ratio schedules of reinforcement. The results showed that rats that were singly housed in the nonenriched environment fell into two groups: low drug-takers (n=34) and high drug-takers (n=12). In comparison, only one out of the 22 rats housed in the enriched environment was a high drug-taker. Thus, all rats in the enriched environment, except one, behaved like low drug-takers under the nonenriched condition. As such, these rats self-administered almost no drug on either the fixed ratio or the progressive ratio schedule of reinforcement and were extremely slow to self-administer their first cocaine infusion. Interestingly, despite their very low levels of drug self-administration, low-drug-taking rats housed in the enriched environment continued to avoid intake of the drug-associated saccharin cue. Taken together, these data suggest that the enriched environment itself served as a salient natural reward that reduced cocaine seeking and cocaine taking, but

  3. Protective Immunity against Murine Hepatitis Virus (MHV) Induced by Intranasal or Subcutaneous Administration of Hybrids of Tobacco Mosaic Virus That Carries an MHV Epitope

    NASA Astrophysics Data System (ADS)

    Koo, Moses; Bendahmane, Mohammed; Lettieri, Gerard A.; Paoletti, Alyssa D.; Lane, Thomas E.; Fitchen, John H.; Buchmeier, Michael J.; Beachy, Roger N.

    1999-07-01

    Hybrids of tobacco mosaic virus (TMV) were constructed with the use of fusion to the coat protein peptides of 10 or 15 amino acids, containing the 5B19 epitope from the spike protein of murine hepatitis virus (MHV) and giving rise to TMV-5B19 and TMV-5B19L, respectively. The TMV hybrids were propagated in tobacco plants, and the virus particles were purified. Immunogold labeling, with the use of the monoclonal MAb5B19 antibody, showed specific decoration of hybrid TMV particles, confirming the expression and display of the MHV epitope on the surface of the TMV. Mice were immunized with purified hybrid viruses after several regimens of immunization. Mice that received TMV-5B19L intranasally developed serum IgG and IgA specific for the 5B19 epitope and for the TMV coat protein. Hybrid TMV-5B19, administered by subcutaneous injections, elicited high titers of serum IgG that was specific for the 5B19 epitope and for coat protein, but IgA that was specific against 5B19 was not observed. Mice that were immunized with hybrid virus by subcutaneous or intranasal routes of administration survived challenge with a lethal dose (10 × LD50) of MHV strain JHM, whereas mice administered wild-type TMV died 10 d post challenge. Furthermore, there was a positive correlation between the dose of administered immunogen and protection against MHV infection. These studies show that TMV can be an effective vaccine delivery vehicle for parenteral and mucosal immunization and for protection from challenge with viral infection.

  4. Co-administration of the broad-spectrum antiviral, brincidofovir (CMX001), with smallpox vaccine does not compromise vaccine protection in mice challenged with ectromelia virus.

    PubMed

    Parker, Scott; Crump, Ryan; Foster, Scott; Hartzler, Hollyce; Hembrador, Ed; Lanier, E Randall; Painter, George; Schriewer, Jill; Trost, Lawrence C; Buller, R Mark

    2014-11-01

    Natural orthopoxvirus outbreaks such as vaccinia, cowpox, cattlepox and buffalopox continue to cause morbidity in the human population. Monkeypox virus remains a significant agent of morbidity and mortality in Africa. Furthermore, monkeypox virus's broad host-range and expanding environs make it of particular concern as an emerging human pathogen. Monkeypox virus and variola virus (the etiological agent of smallpox) are both potential agents of bioterrorism. The first line response to orthopoxvirus disease is through vaccination with first-generation and second-generation vaccines, such as Dryvax and ACAM2000. Although these vaccines provide excellent protection, their widespread use is impeded by the high level of adverse events associated with vaccination using live, attenuated virus. It is possible that vaccines could be used in combination with antiviral drugs to reduce the incidence and severity of vaccine-associated adverse events, or as a preventive in individuals with uncertain exposure status or contraindication to vaccination. We have used the intranasal mousepox (ectromelia) model to evaluate the efficacy of vaccination with Dryvax or ACAM2000 in conjunction with treatment using the broad spectrum antiviral, brincidofovir (BCV, CMX001). We found that co-treatment with BCV reduced the severity of vaccination-associated lesion development. Although the immune response to vaccination was quantifiably attenuated, vaccination combined with BCV treatment did not alter the development of full protective immunity, even when administered two days following ectromelia challenge. Studies with a non-replicating vaccine, ACAM3000 (MVA), confirmed that BCV's mechanism of attenuating the immune response following vaccination with live virus was, as expected, by limiting viral replication and not through inhibition of the immune system. These studies suggest that, in the setting of post-exposure prophylaxis, co-administration of BCV with vaccination should be considered

  5. Analysis of U.S. Food and Drug Administration food allergen recalls after implementation of the food allergen labeling and consumer protection act.

    PubMed

    Gendel, Steven M; Zhu, Jianmei

    2013-11-01

    To avoid potentially life-threatening reactions, food allergic consumers rely on information on food labels to help them avoid exposure to a food or ingredient that could trigger a reaction. To help consumers in the United States obtain the information that they need, the Food Allergen Labeling and Consumer Protection Act of 2004 defined a major food allergen as being one of eight foods or food groups and any ingredient that contains protein from one of these foods or food groups. A food that contains an undeclared major food allergen is misbranded under the U.S. Food, Drug, and Cosmetic Act and is subject to recall. Food allergen labeling problems are the most common cause of recalls for U.S. Food and Drug Administration (FDA)-regulated food products. To help understand why food allergen recalls continue to occur at a high rate, information on each food allergen recall that occurred in fiscal years 2007 through 2012 was obtained from the FDA recall database. This information was analyzed to identify the food, allergen, root cause, and mode of discovery for each food allergen recall. Bakery products were the most frequently recalled food type, and milk was the most frequently undeclared major food allergen. Use of the wrong package or label was the most frequent problem leading to food allergen recalls. These data are the first reported that indicate the importance of label and package controls as public health measures.

  6. The influence of antiobesity media content on intention to eat healthily and exercise: a test of the ordered protection motivation theory.

    PubMed

    Ritland, Raeann; Rodriguez, Lulu

    2014-01-01

    This study extended the ordered protection motivation framework to determine whether exposure and attention to antiobesity media content increases people's appraisals of threat and their ability to cope with it. It also assesses whether these cognitive processes, in turn, affected people's intention to abide by the practices recommended to prevent obesity. The results of a national online survey using a nonprobability sample indicate that attention to mediated obesity and related information significantly increased people's intention to exercise as well as their overall coping appraisals (the perceived effectiveness of the recommended behaviors and their ability to perform them). Likewise, increased threat and coping appraisals were both found to significantly influence people's intention to exercise and diet. Coping (rather than threat) appraisals more strongly predicted behavioral intent. Following the attitude-behavior literature, behavioral intention was used as the most proximate predictor of actual behavior (i.e., stronger intentions increase the likelihood of behavior change).

  7. The Influence of Antiobesity Media Content on Intention to Eat Healthily and Exercise: A Test of the Ordered Protection Motivation Theory

    PubMed Central

    Ritland, Raeann; Rodriguez, Lulu

    2014-01-01

    This study extended the ordered protection motivation framework to determine whether exposure and attention to antiobesity media content increases people's appraisals of threat and their ability to cope with it. It also assesses whether these cognitive processes, in turn, affected people's intention to abide by the practices recommended to prevent obesity. The results of a national online survey using a nonprobability sample indicate that attention to mediated obesity and related information significantly increased people's intention to exercise as well as their overall coping appraisals (the perceived effectiveness of the recommended behaviors and their ability to perform them). Likewise, increased threat and coping appraisals were both found to significantly influence people's intention to exercise and diet. Coping (rather than threat) appraisals more strongly predicted behavioral intent. Following the attitude-behavior literature, behavioral intention was used as the most proximate predictor of actual behavior (i.e., stronger intentions increase the likelihood of behavior change). PMID:25505981

  8. 28 CFR 68.57 - Judicial review of the final agency order of an Administrative Law Judge in cases arising under...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the final agency order in the United States Court of Appeals for the circuit in which the violation is... a petition in the United States District Court for the district in which the violation that is the... IMMIGRATION-RELATED EMPLOYMENT PRACTICES, AND DOCUMENT FRAUD § 68.57......

  9. Is length of shelter stay and receipt of a protection order associated with less violence and better functioning for abused women? Outcome data 4 months after receiving services.

    PubMed

    McFarlane, Judith; Symes, Lene; Maddoux, John; Gilroy, Heidi; Koci, Anne

    2014-10-01

    To provide differential effectiveness on length of stay at a shelter and receipt versus non-receipt of a protection order (PO), and outcomes of violence, functioning, and resiliency, in 300 abused women (150 first-time users of a shelter and 150 first-time applicants for a PO) who participate in a 7-year study with outcomes measured every 4 months. Four months after a shelter stay or application for a PO, abused women staying 21 days or less at a shelter reported similar outcomes compared with women staying longer than 21 days. Similarly, women receiving and not receiving a PO reported overall equivalent outcomes. Seeking shelter or justice services results in similar improved outcomes for abused women 4 months later, regardless of length of stay at the shelter or receipt or no receipt of the PO. Contact with shelter and justice services results in positive outcomes for abused women and indicates the urgent need to increase availability, accessibility, and acceptability of shelter and justice services.

  10. Acute administration of nicotine into the higher order auditory Te2 cortex specifically decreases the fear-related charge of remote emotional memories.

    PubMed

    Cambiaghi, Marco; Grosso, Anna; Renna, Annamaria; Concina, Giulia; Sacchetti, Benedetto

    2015-12-01

    Nicotine elicits several behavioural effects on mood as well as on stress and anxiety processes. Recently, it was found that the higher order components of the sensory cortex, such as the secondary auditory cortex Te2, are essential for the long-term storage of remote fear memories. Therefore, in the present study, we examined the effects of acute nicotine injection into the higher order auditory cortex Te2, on the remote emotional memories of either threat or incentive experiences in rats. We found that intra-Te2 nicotine injection decreased the fear-evoked responses to a tone previously paired with footshock. This effect was cue- and dose-specific and was not due to any interference with auditory stimuli processing, innate anxiety and fear processes, or with motor responses. Nicotine acts acutely in the presence of threat stimuli but it did not determine the permanent degradation of the fear-memory trace, since memories tested one week after nicotine injection were unaffected. Remarkably, nicotine did not affect the memory of a similar tone that was paired to incentive stimuli. We conclude from our results that nicotine, when acting acutely in the auditory cortex, relieves the fear charge embedded by learned stimuli. PMID:26319210

  11. Acute administration of nicotine into the higher order auditory Te2 cortex specifically decreases the fear-related charge of remote emotional memories.

    PubMed

    Cambiaghi, Marco; Grosso, Anna; Renna, Annamaria; Concina, Giulia; Sacchetti, Benedetto

    2015-12-01

    Nicotine elicits several behavioural effects on mood as well as on stress and anxiety processes. Recently, it was found that the higher order components of the sensory cortex, such as the secondary auditory cortex Te2, are essential for the long-term storage of remote fear memories. Therefore, in the present study, we examined the effects of acute nicotine injection into the higher order auditory cortex Te2, on the remote emotional memories of either threat or incentive experiences in rats. We found that intra-Te2 nicotine injection decreased the fear-evoked responses to a tone previously paired with footshock. This effect was cue- and dose-specific and was not due to any interference with auditory stimuli processing, innate anxiety and fear processes, or with motor responses. Nicotine acts acutely in the presence of threat stimuli but it did not determine the permanent degradation of the fear-memory trace, since memories tested one week after nicotine injection were unaffected. Remarkably, nicotine did not affect the memory of a similar tone that was paired to incentive stimuli. We conclude from our results that nicotine, when acting acutely in the auditory cortex, relieves the fear charge embedded by learned stimuli.

  12. Acute administration of nicotine into the higher order auditory Te2 cortex specifically decreases the fear-related charge of remote emotional memories

    PubMed Central

    Cambiaghi, Marco; Grosso, Anna; Renna, Annamaria; Concina, Giulia; Sacchetti, Benedetto

    2015-01-01

    Nicotine elicits several behavioural effects on mood as well as on stress and anxiety processes. Recently, it was found that the higher order components of the sensory cortex, such as the secondary auditory cortex Te2, are essential for the long-term storage of remote fear memories. Therefore, in the present study, we examined the effects of acute nicotine injection into the higher order auditory cortex Te2, on the remote emotional memories of either threat or incentive experiences in rats. We found that intra-Te2 nicotine injection decreased the fear-evoked responses to a tone previously paired with footshock. This effect was cue- and dose-specific and was not due to any interference with auditory stimuli processing, innate anxiety and fear processes, or with motor responses. Nicotine acts acutely in the presence of threat stimuli but it did not determine the permanent degradation of the fear-memory trace, since memories tested one week after nicotine injection were unaffected. Remarkably, nicotine did not affect the memory of a similar tone that was paired to incentive stimuli. We conclude from our results that nicotine, when acting acutely in the auditory cortex, relieves the fear charge embedded by learned stimuli. PMID:26319210

  13. ADMINISTRATION OF A SUBSTITUTED ADAMANTLY-UREA INHIBITOR OF THE SOLUBLE EPOXIDE HYDROLASE PROTECTS THE KIDNEY FROM DAMAGE IN HYPERTENSIVE GOTO-KAKIZAKI RATS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Hypertension and type II diabetes are co-morbid diseases that lead to the development of nephropathy. Soluble epoxide hydrolase (sEH) inhibitors are reported to provide protection from renal injury. We hypothesized that the sEH inhibitor 12-(3-adamantan-1-yl-ureido) dodecanoic acid (AUDA) protects ...

  14. 77 FR 76075 - Whistleblower Protection Advisory Committee (WPAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ..., 2008), Secretary of Labor's Order 1-2012 (Jan. 18, 2012), 77 FR 3912 (Jan. 25, 2012), and the Secretary... Occupational Safety and Health Administration Whistleblower Protection Advisory Committee (WPAC) AGENCY... protection statutes enforced by OSHA; Public comments. OSHA transcribes WPAC meetings and prepares...

  15. Administration of interleukin-10 at the time of priming protects Corynebacterium parvum-primed mice against LPS- and TNF-alpha-induced lethality.

    PubMed

    Smith, S R; Terminelli, C; Denhardt, G; Narula, S; Thorbecke, G J

    1996-11-01

    Several laboratories have described the protective effects of interleukin-10 (IL-10) in mouse models of lethal endotoxemia. In most of these experiments, protection was observed in normal mice that were given a lethal dose of LPS. However, we failed to observe protection with IL-10 in LPS-challenged mice that had been primed with Corynebacterium parvum (Proprionibacterium acnes). We have extended our studies with IL-10 in C. parvum-primed mice and in some cases have observed protection that appears to depend on the strength of the sensitization to C. parvum. When IL-10 was administered to mice at the time of priming, it was particularly effective in blocking sensitization, as evidenced by the inability of treated mice to mount a strong inflammatory cytokine response when subsequently challenged with LPS. Following such treatment with IL-10, C. parvum-primed mice were also protected from a subsequent lethal challenge with rMuTNF-alpha. In addition, the mice were protected against LPS- and TNF-alpha-induced lethality with a single dose of an anti-TNF-alpha or anti-IFN-gamma mAb given at the time of priming. Our results suggest that TNF-alpha and IFN-gamma are produced early after priming with C. parvum and are at least partly responsible for the enhanced sensitivity of the mice to LPS and TNF-alpha. IL-10 affords protection to the mice because of its ability to block the C. parvum-induced TNF-alpha and IFN-gamma responses. PMID:8912878

  16. 78 FR 5116 - NASA Information Security Protection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    ... Executive Order of 13132 E.O. 13132, ``Federalism,'' 64 FR 43255 (August 4, 1999) requires regulations be... SPACE ADMINISTRATION 14 CFR Part 1203 RIN 2700-AD61 NASA Information Security Protection AGENCY..., Classified National Security Information, and appropriately to correspond with NASA's internal...

  17. 29 CFR 801.66 - Consent findings and order.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 3 2014-07-01 2014-07-01 false Consent findings and order. 801.66 Section 801.66 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Procedures...

  18. 29 CFR 801.66 - Consent findings and order.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Consent findings and order. 801.66 Section 801.66 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Procedures...

  19. 29 CFR 801.66 - Consent findings and order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Consent findings and order. 801.66 Section 801.66 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Procedures...

  20. 29 CFR 801.66 - Consent findings and order.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Consent findings and order. 801.66 Section 801.66 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Procedures...

  1. 29 CFR 801.66 - Consent findings and order.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Consent findings and order. 801.66 Section 801.66 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS APPLICATION OF THE EMPLOYEE POLYGRAPH PROTECTION ACT OF 1988 Administrative Proceedings Procedures...

  2. 5 CFR 1203.21 - Final order of the Board.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1203.21 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PROCEDURES FOR REVIEW OF RULES AND REGULATIONS OF THE OFFICE OF PERSONNEL MANAGEMENT Order of the Board § 1203.21... related to the cancelled personnel action; (3) Removal of any reference, record, or document within...

  3. 39 CFR 3007.61 - Continued effectiveness of protective conditions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 3007.61 Section 3007.61 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL TREATMENT OF NON-PUBLIC... a court or other administrative agency issues a subpoena or orders production of non-public materials which a person has obtained under protective conditions ordered by the Commission, the target...

  4. 78 FR 5122 - NASA Security and Protective Services Enforcement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-24

    .... 3501 et seq.). Review Under Executive Order of 13132 Executive Order 13132, ``Federalism,'' 64 FR 43255... SPACE ADMINISTRATION 14 CFR Parts 1203a, 1203b, and 1204 RIN 2700-AD89 NASA Security and Protective.... SUMMARY: This direct final rule makes nonsubstantive changes to NASA regulations to clarify the...

  5. Simultaneous subcutaneous and conjunctival administration of the influenza viral vector based Brucella abortus vaccine to pregnant heifers provides better protection against B. abortus 544 infection than the commercial B. abortus S19 vaccine.

    PubMed

    Tabynov, Kaissar; Orynbayev, Mukhit; Renukaradhya, Gourapura J; Sansyzbay, Abylai

    2016-09-30

    In this study, we explored possibility of increasing the protective efficacy of our novel influenza viral vector based B. abortus vaccine (Flu-BA) in pregnant heifers by adapting an innovative method of vaccine delivery. We administered the vaccine concurrently via the conjunctival and subcutaneous routes to pregnant heifers, and these routes were previously tested individually. The Flu-BA vaccination of pregnant heifers (n=9) against a challenge B. abortus 544 infection provided protection from abortion, infection of heifers and fetuses/calves by 88.8%, 100% and 100%, respectively (alpha=0.004-0.0007 vs. negative control; n=7). Our candidate vaccine using this delivery method provided slightly better protection than the commercial B. abortus S19 vaccine in pregnant heifers (n=8), which provided protection from abortion, infection of heifers and fetuses/calves by 87.5%, 75% and 87.5%, respectively. This improved method of the Flu-BA vaccine administration is highly recommended for the recovery of farms which has high prevalence of brucellosis.

  6. Simultaneous subcutaneous and conjunctival administration of the influenza viral vector based Brucella abortus vaccine to pregnant heifers provides better protection against B. abortus 544 infection than the commercial B. abortus S19 vaccine.

    PubMed

    Tabynov, Kaissar; Orynbayev, Mukhit; Renukaradhya, Gourapura J; Sansyzbay, Abylai

    2016-09-30

    In this study, we explored possibility of increasing the protective efficacy of our novel influenza viral vector based B. abortus vaccine (Flu-BA) in pregnant heifers by adapting an innovative method of vaccine delivery. We administered the vaccine concurrently via the conjunctival and subcutaneous routes to pregnant heifers, and these routes were previously tested individually. The Flu-BA vaccination of pregnant heifers (n=9) against a challenge B. abortus 544 infection provided protection from abortion, infection of heifers and fetuses/calves by 88.8%, 100% and 100%, respectively (alpha=0.004-0.0007 vs. negative control; n=7). Our candidate vaccine using this delivery method provided slightly better protection than the commercial B. abortus S19 vaccine in pregnant heifers (n=8), which provided protection from abortion, infection of heifers and fetuses/calves by 87.5%, 75% and 87.5%, respectively. This improved method of the Flu-BA vaccine administration is highly recommended for the recovery of farms which has high prevalence of brucellosis. PMID:27595898

  7. Co-administration of monoisoamyl dimercaptosuccinic acid and Moringa oleifera seed powder protects arsenic-induced oxidative stress and metal distribution in mice.

    PubMed

    Mishra, Deepshikha; Gupta, Richa; Pant, S C; Kushwah, Pramod; Satish, H T; Flora, S J S

    2009-02-01

    Arsenic contamination of groundwater in the West Bengal basin in India is unfolding as one of the worst natural geo-environmental disasters to date. Chelation therapy with chelating agents is considered to be the best known treatment against arsenic poisoning; however, they are compromised with certain serious drawbacks/side-effects. Efficacy of combined administration of Moringa oleifera (M. oleifera) (English: Drumstick tree) seed powder, a herbal extract, with a thiol chelator monoisoamyl DMSA (MiADMSA) post-arsenic exposure in mice was studied. Mice were exposed to 100 ppm arsenic in drinking water for 6 months, followed by 10-days treatment with M. oleifera seed powder (500 mg/kg, orally through gastric gavage, once daily), MiADMSA (50 mg/kg, intraperitoneally, once daily) either individually or in combination. Arsenic exposure caused significant decrease in blood glutathione, delta-aminolevulinic acid dehydratase (ALAD), accompanied by increased production of reactive oxygen species in blood and soft tissues. Significant inhibition of superoxide dismutase, catalase, and glutathione peroxidase activities in tissues (liver in particular) along with significant increase in thiobarbituric acid reactive substances and metallothionein levels in arsenic intoxicated mice was also noted. Combined administration of MiADMSA with M. oleifera proved better than all other treatments in the recovery of most of the above parameters accompanied by more pronounced depletion of arsenic. The results suggest that concomitant administration of M. oleifera during chelation treatment with MiADMSA might be a better treatment option than monotherapy with the thiol chelator in chronic arsenic toxicity.

  8. Protection against Rift Valley fever virus infection in mice upon administration of interferon-inducing RNA transcripts from the FMDV genome.

    PubMed

    Lorenzo, Gema; Rodríguez-Pulido, Miguel; López-Gil, Elena; Sobrino, Francisco; Borrego, Belén; Sáiz, Margarita; Brun, Alejandro

    2014-09-01

    In this work we have addressed the effect of synthetic, non-infectious, RNA transcripts, mimicking structural domains of the non-coding regions (NCRs) of the foot-and-mouth disease virus (FMDV) genome on the infection of mice with Rift Valley fever virus (RVFV). Groups of 5 mice were inoculated intraperitoneally (i.p.) with 200 μg of synthetic RNA resembling the 5'-terminal S region, the internal ribosome entry site (IRES) or the 3'-NCR of the FMDV genome. RNA inoculation was performed 24h before (-24 h), 24 h after (+24 h) or simultaneously to the challenge with a lethal dose of RVFV. Administration of the IRES RNA afforded higher survival rates than administration of S or 3'NCR transcripts either at -24h or +24h after challenge. In contrast, when RNA inoculation and viral challenge were performed simultaneously, all mice survived in both IRES- and 3'NCR-inoculated groups, with an 80% survival in mice receiving the S RNA. Among survivors, a complete correlation between significant anti-RVFV circulating antibody titers and resistance to a second lethal challenge with the virus was observed, supporting a limited viral replication in the RNA-inoculated animals upon the first challenge. All three RNA transcripts were able to induce the production of systemic antiviral and pro-inflammatory cytokines. These data show that triggering of intracellular pathogen sensing pathways constitutes a promising approach towards development of novel RVF preventive or therapeutic strategies. PMID:24973761

  9. Therapeutic Administration of KM+ Lectin Protects Mice Against Paracoccidioides brasiliensis Infection via Interleukin-12 Production in a Toll-Like Receptor 2-Dependent Mechanism

    PubMed Central

    Coltri, Kely C.; Oliveira, Leandro L.; Pinzan, Camila F.; Vendruscolo, Patrícia E.; Martinez, Roberto; Goldman, Maria Helena; Panunto-Castelo, Ademilson; Roque-Barreira, Maria-Cristina

    2008-01-01

    KM+ is a mannose-binding lectin from Artocarpus integrifolia that induces interleukin (IL)-12 production by macrophages and protective T helper 1 immune response against Leishmania major infection. In this study, we performed experiments to evaluate the therapeutic activity of jackfruit KM+ (jfKM+) and its recombinant counterpart (rKM+) in experimental paracoccidioidomycosis. To this end, jfKM+ or rKM+ was administered to BALB/c mice 10 days after infection with Paracoccidiodes brasiliensis. Thirty days postinfection, lungs from the KM+-treated mice contained significantly fewer colony-forming units and little to no organized granulomas compared to the controls. In addition, lung homogenates from the KM+-treated mice presented higher levels of nitric oxide, IL-12, interferon-γ, and tumor necrosis factor-α, whereas higher levels of IL-4 and IL-10 were detected in the control group. With mice deficient in IL-12, Toll-like receptor (TLR) 2, TLR4, or TLR adaptor molecule MyD88, we demonstrated that KM+ led to protection against P. brasiliensis infection through IL-12 production, which was dependent on TLR2. These results demonstrated a beneficial effect of KM+ on the severity of P. brasiliensis infection and may expand its potential use as a novel immunotherapeutic molecule. PMID:18599609

  10. A single administration of the peptide NAP induces long-term protective changes against the consequences of head injury: gene Atlas array analysis.

    PubMed

    Romano, Jacob; Beni-Adani, Liana; Nissenbaum, Orlev Levy; Brenneman, Douglas E; Shohami, Esther; Gozes, Illana

    2002-01-01

    The femtomolar-acting eight-amino-acid peptide (NAP), derived from activity-dependent neuroprotective protein (ADNP), provides long-term protection against the deleterious effects of closed head injury (CHI) in mice. Fifteen minutes after injury, mice were divided into two groups, control and NAP-treated and a single subcutaneous injection of NAP or vehicle was administered. A third group served as sham-treated (not subjected to head trauma). Each mouse was assessed for its clinical function, using neurological severity score, at various time intervals following CHI, up to 30-45 d. Total cerebral cortex RNA was prepared from the site of injury of CHI mice, and from parallel regions in peptide-treated and sham brains. RNA was then reversed transcribed to yield radioactive cDNA preparations that were hybridized to Atlas array membranes containing 1200 cDNAs spots. Comparison of sham-treated individual mice showed differential expression levels of at least 15 mRNA species. Furthermore, results indicated that one of the genes that did not change among individuals but specifically increased after CHI and decreased after NAP treatment was the cell surface glycoprotein Mac-1 (CD11B antigen). Thus, Mac-1 is suggested as a marker for the long-term outcome of head injury and as a potential target for NAP protective actions.

  11. Therapeutic administration of KM+ lectin protects mice against Paracoccidioides brasiliensis infection via interleukin-12 production in a toll-like receptor 2-dependent mechanism.

    PubMed

    Coltri, Kely C; Oliveira, Leandro L; Pinzan, Camila F; Vendruscolo, Patrícia E; Martinez, Roberto; Goldman, Maria Helena; Panunto-Castelo, Ademilson; Roque-Barreira, Maria-Cristina

    2008-08-01

    KM(+) is a mannose-binding lectin from Artocarpus integrifolia that induces interleukin (IL)-12 production by macrophages and protective T helper 1 immune response against Leishmania major infection. In this study, we performed experiments to evaluate the therapeutic activity of jackfruit KM(+) (jfKM(+)) and its recombinant counterpart (rKM(+)) in experimental paracoccidioidomycosis. To this end, jfKM(+) or rKM(+) was administered to BALB/c mice 10 days after infection with Paracoccidiodes brasiliensis. Thirty days postinfection, lungs from the KM(+)-treated mice contained significantly fewer colony-forming units and little to no organized granulomas compared to the controls. In addition, lung homogenates from the KM(+)-treated mice presented higher levels of nitric oxide, IL-12, interferon-gamma, and tumor necrosis factor-alpha, whereas higher levels of IL-4 and IL-10 were detected in the control group. With mice deficient in IL-12, Toll-like receptor (TLR) 2, TLR4, or TLR adaptor molecule MyD88, we demonstrated that KM(+) led to protection against P. brasiliensis infection through IL-12 production, which was dependent on TLR2. These results demonstrated a beneficial effect of KM(+) on the severity of P. brasiliensis infection and may expand its potential use as a novel immunotherapeutic molecule.

  12. Test Administration Models

    ERIC Educational Resources Information Center

    Becker, Kirk A.; Bergstrom, Betty A.

    2013-01-01

    The need for increased exam security, improved test formats, more flexible scheduling, better measurement, and more efficient administrative processes has caused testing agencies to consider converting the administration of their exams from paper-and-pencil to computer-based testing (CBT). Many decisions must be made in order to provide an optimal…

  13. Goldstone (GDSCC) administrative computing

    NASA Technical Reports Server (NTRS)

    Martin, H.

    1981-01-01

    The GDSCC Data Processing Unit provides various administrative computing services for Goldstone. Those activities, including finance, manpower and station utilization, deep-space station scheduling and engineering change order (ECO) control are discussed.

  14. Protective effect of systemic L-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25-35) in rat hippocampus.

    PubMed

    Carrillo-Mora, Paul; Méndez-Cuesta, Luis A; Pérez-De La Cruz, Verónica; Fortoul-van Der Goes, Teresa I; Santamaría, Abel

    2010-07-11

    Amyloid beta (Abeta) peptide exerts different toxic effects at a cellular level, including over-activation of N-methyl-D-aspartate receptor (NMDAr) and excitotoxicity, synaptic dysfunction and neuronal death. Kynurenic acid (KYNA) is an endogenous antagonist of NMDAr and alpha7 nicotinic receptors. Systemic administrations of both the immediate metabolic precursor of KYNA, L-kynurenine (L-KYN), and a proved inhibitor of KYNA's brain transport, probenecid (PROB), have shown to produce neuroprotective effects in a considerable number of experimental toxic conditions; however, this strategy has not been tested in the toxic model Abeta peptide so far. In this study we evaluated the effects of systemic administration of PROB (50 mg/kg/day for 7 days), L-KYN (75 mg/kg/day for 7 days) and their combination, on behavioural (locomotor activity and spatial memory) and morphological alterations induced by an intrahippocampal infusion of Abeta 25-35 to rats. An additional group was administered with the potent NMDAr antagonist dizocilpine (MK-801, 0.8 mg/kg/day for 7 days) for comparative purposes. A significant improvement of spatial memory was evident in Abeta-lesioned rats since post-lesion day 21 with all treatments tested and this effect was correlated with a reduction of cell damage and a decrease in reactive gliosis in hippocampal CA1 area. Neither L-KYN, nor PROB, or their combination, produced major alterations in motor function when given alone to rats. These results suggest that modulation of NMDAr activity by mean of therapeutic strategies designed to enhance KYNA in the brain may help to counteract neurodegenerative events coursing with Abeta toxicity and excitotoxic patterns.

  15. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease.

    PubMed

    Olcese, James M; Cao, Chuanhai; Mori, Takashi; Mamcarz, Malgorzata B; Maxwell, Anne; Runfeldt, Melissa J; Wang, Li; Zhang, Chi; Lin, Xiaoyang; Zhang, Guixin; Arendash, Gary W

    2009-08-01

    The neurohormone melatonin has been reported to exert anti-beta-amyloid aggregation, antioxidant, and anti-inflammatory actions in various in vitro and animal models. To comprehensively determine the potential for long-term melatonin treatment to protect Alzheimer's transgenic mice against cognitive impairment and development of beta-amyloid (Abeta) neuropathology, we administered melatonin (100 mg/L drinking water) to APP + PS1 double transgenic (Tg) mice from 2-2.5 months of age to their killing at age 7.5 months. A comprehensive behavioral battery administered during the final 6 weeks of treatment revealed that Tg mice given melatonin were protected from cognitive impairment in a variety of tasks of working memory, spatial reference learning/memory, and basic mnemonic function; Tg control mice remained impaired in all of these cognitive tasks/domains. Immunoreactive Abeta deposition was significantly reduced in hippocampus (43%) and entorhinal cortex (37%) of melatonin-treated Tg mice. Although soluble and oligomeric forms of Abeta1-40 and 1-42 were unchanged in the hippocampus and cortex of the same melatonin-treated Tg mice, their plasma Abeta levels were elevated. These Abeta results, together with our concurrent demonstration that melatonin suppresses Abeta aggregation in brain homogenates, are consistent with a melatonin-facilitated removal of Abeta from the brain. Inflammatory cytokines such as tumor necrosis factor (TNF)-alpha were decreased in hippocampus (but not plasma) of Tg+ melatonin mice. Finally, the cortical mRNA expression of three antioxidant enzymes (SOD-1, glutathione peroxidase, and catalase) was significantly reduced to non-Tg levels by long-term melatonin treatment in Tg mice. Thus, melatonin's cognitive benefits could involve its anti-Abeta aggregation, anti-inflammatory, and/or antioxidant properties. Our findings provide support for long-term melatonin therapy as a primary or complementary strategy for abating the progression of

  16. Administrative Synergy

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  17. Long-term ethanol administration enhances age-dependent modulation of redox state in central and peripheral organs of rat: protection by metadoxine.

    PubMed

    Calabrese, V; Randazzo, G; Ragusa, N; Rizza, V

    1998-01-01

    Evidence is accumulating that intermediates of oxygen reduction may be associated with the development of alcoholic disease. In addition, free radical-induced perturbation of the oxidant/antioxidant balance in cells is widely recognized as the main causative factor of age-related disorders. In the present work, we investigated the effects of 25 months of ethanol consumption on the antioxidant defense system in different organs of rat in comparison with normal aging, in the absence and presence of treatment with metadoxine, an ion pair composed of pirrolidone carboxylate and pyridoxine. We demonstrate that aged rats underwent a significant perturbation of the antioxidant defense system, as indicated by depletion of reduced glutathione (GSH) content, and increases in oxidized GSH and free radical-induced luminescence associated with a decrease of GSH reductase and an increase of GSH transferase activities. These modifications, observed particularly in the liver and brain with respect to other organs, were enhanced by long-term alcohol exposure, and interestingly, significantly reduced after metadoxine supplementation. Our results indicate that increased GSH transferase activity and decreased GSH reductase activity, followed by thiol depletion, are important factors sustaining a pathogenic role for oxidative stress in aging and in all situations where age-correlated changes occur. Administration of metadoxine greatly reduces these metabolic abnormalities. This evidence supports the pharmacological potential of metadoxine in the management of alcoholic disturbances. PMID:9675549

  18. Protection against Foot-and-Mouth Disease Virus in Guinea Pigs via Oral Administration of Recombinant Lactobacillus plantarum Expressing VP1

    PubMed Central

    Wang, Miao; Pan, Li; Zhou, Peng; Lv, Jianliang; Zhang, Zhongwang; Wang, Yonglu; Zhang, Yongguang

    2015-01-01

    Mucosal vaccination is an effective strategy for generating antigen-specific immune responses against mucosal infections of foot-and-mouth disease virus (FMDV). In this study, Lactobacillus plantarum strains NC8 and WCFS1 were used as oral delivery vehicles containing a pSIP411-VP1 recombinant plasmid to initiate mucosal and systemic immune responses in guinea pigs. Guinea pigs were orally vaccinated (three doses) with NC8-pSIP411, NC8-pSIP411-VP1, WCFS1-pSIP411, WCFS1-pSIP411-VP1 or milk. Animals immunized with NC8-pSIP411-VP1 and WCFS1-pSIP411-VP1 developed high levels of antigen-specific serum IgG, IgA, IgM, mucosal secretory IgA (sIgA) and neutralizing antibodies, and revealed stronger cell-mediated immune responses and enhanced protection against FMDV challenge compared with control groups. The recombinant pSIP411-VP1 effectively improved immunoprotection against FMDV in guinea pigs. PMID:26629822

  19. 40 CFR 108.7 - Hearing before Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Hearing before Administrator. 108.7 Section 108.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EMPLOYEE PROTECTION HEARINGS § 108.7 Hearing before Administrator. At his option, the Administrator...

  20. 40 CFR 108.7 - Hearing before Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Hearing before Administrator. 108.7 Section 108.7 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EMPLOYEE PROTECTION HEARINGS § 108.7 Hearing before Administrator. At his option, the Administrator...

  1. Protective effects of vitamins (C and E) and melatonin co-administration on hematological and hepatic functions and oxidative stress in alloxan-induced diabetic rats.

    PubMed

    Allagui, Mohamed Salah; Feriani, Anouer; Bouoni, Zouhour; Alimi, Hichem; Murat, Jean Claud; El Feki, Abdelfattah

    2014-09-01

    The present study aimed to investigate the potential effects of vitamins (C and E)/melatonin co-administration on the hematologic and hepatic functions and oxidative stress in alloxan-induced diabetic rats. The intraperitoneal injection of alloxan (120 mg/kg b.w. for 2 days) induced a significant increase of blood glucose levels (hyperglycemia) associated with serious hematologic disorders (P < 0.01) evidenced by the decrease in the levels of red blood cell count (RBC) (-18%), hematocrit (Ht) (-18%), hemoglobin content (Hb) (-36%), mean corpuscular hemoglobin (MCH) (-17%), and mean corpuscular hemoglobin concentration (MCHC) (-16%). The activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and the plasmatic levels of total cholesterol and triglyceride contents of diabetic rats were, however, noted to undergo significant increases by 42% (P < 0.01), 134% (P < 0.001), 27.5% (P < 0.01), 147% (P < 0.001), and 67% (P < 0.01), respectively, as compared to the control animals. Furthermore, a significant increase in malondialdehyde (MDA) content and a significant decrease in superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were observed in the plasma and hepatic tissues of diabetic rats when compared to the controls. Interestingly, the treatment with vitamins (C, E) in combination with melatonin was noted to reduce the plasma levels of glucose, lower the MDA levels, and restore the hematologic parameters and biochemical and antioxidant levels of diabetic rats back to normal values, alleviating diabetes metabolic disorders in rats. PMID:24919717

  2. 40 CFR 72.12 - Administrative appeals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures...

  3. 40 CFR 72.12 - Administrative appeals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures...

  4. 40 CFR 72.12 - Administrative appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures...

  5. 40 CFR 72.12 - Administrative appeals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures...

  6. 40 CFR 72.12 - Administrative appeals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Administrative appeals. 72.12 Section 72.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Acid Rain Program General Provisions § 72.12 Administrative appeals. The procedures...

  7. 40 CFR 22.42 - Supplemental rules governing the administrative assessment of civil penalties for violations of...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Supplemental rules governing the administrative assessment of civil penalties for violations of compliance orders issued to owners or operators of public water systems under part B of the Safe Drinking Water Act. 22.42 Section 22.42 Protection of Environment ENVIRONMENTAL...

  8. 40 CFR 22.42 - Supplemental rules governing the administrative assessment of civil penalties for violations of...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Supplemental rules governing the administrative assessment of civil penalties for violations of compliance orders issued to owners or operators of public water systems under part B of the Safe Drinking Water Act. 22.42 Section 22.42 Protection of Environment ENVIRONMENTAL...

  9. 40 CFR 22.42 - Supplemental rules governing the administrative assessment of civil penalties for violations of...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Supplemental rules governing the administrative assessment of civil penalties for violations of compliance orders issued to owners or operators of public water systems under part B of the Safe Drinking Water Act. 22.42 Section 22.42 Protection of Environment ENVIRONMENTAL...

  10. Co-administration of rIpaB domain of Shigella with rGroEL of S. Typhi enhances the immune responses and protective efficacy against Shigella infection

    PubMed Central

    Chitradevi, Sekar Tamil Selvi; Kaur, Gurpreet; Uppalapati, Sivaramakrishna; Yadav, Anandprakash; Singh, Dependrapratap; Bansal, Anju

    2015-01-01

    Shigella species cause severe bacillary dysentery in humans and are associated with high morbidity and mortality. The Invasion plasmid antigen (IpaB) protein, which is conserved across all Shigella spp., induces macrophage cell death and is required to invade host cells. The present study evaluates the immunogenicity and protective efficacy of the recombinant (r) domain region of IpaB (rIpaB) of S. flexneri. rIpaB was administered either alone or was co-administered with the rGroEL (heat shock protein 60) protein from S. Typhi as an adjuvant in a mouse model of intranasal immunization. The IpaB domain region (37 kDa) of S. flexneri was amplified from an invasion plasmid, cloned, expressed in BL21 Escherichia coli cells and purified. Immunization with the rIpaB domain alone stimulated both humoral and cell-mediated immune responses. Furthermore, robust antibody (IgG, IgA) and T-cell responses were induced when the rIpaB domain was co-administered with rGroEL. Antibody isotyping revealed higher IgG1 and IgG2a antibody titers and increased interferon-gamma (IFN-γ) secretion in the co-administered group. Immunization of mice with the rIpaB domain alone protected 60%–70% of the mice from lethal infection by S. flexneri, S. boydii and S. sonnei, whereas co-administration with rGroEL increased the protective efficacy to 80%–85%. Organ burden and histopathological studies also revealed a significant reduction in lung infection in the co-immunized mice compared with mice immunized with the rIpaB domain alone. This study emphasizes that the co-administration of the rIpaB domain and rGroEL protein improves immune responses in mice and increases protective efficacy against Shigella infection. This is also the first report to evaluate the potential of the GroEL (Hsp 60) protein of S. Typhi as an adjuvant molecule, thereby overcoming the need for commercial adjuvants. PMID:25640657

  11. Lightning Protection

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Kit-built airplanes are more affordable because they are assembled by the owner and do not require Federal Aviation Administration (FAA) certification. The Glasair III, is an advanced technology homebuilt, constructed of a fiberglass and graphite fiber composite material, and equipped with digital instruments. Both technologies make the airplane more susceptible to lightning effects. When Glasair manufacturer, Stoddard-Hamilton, decided that lightning protection would enable more extensive instrument flight and make the plane more marketable, they proposed a joint development program to NASA Langley Research Center (LAR). Under a Small Business Innovation Research (SBIR) contract, Langley contractors designed and tested a lightning protection system, and the Glasair III-LP became the first kit-built composite aircraft to be lightning tested and protection-verified under FAA guidelines for general aviation aircraft.

  12. 78 FR 62417 - Import Administration; Change of Agency Name

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... International Trade Administration 19 CFR Parts 351, 354, and 356 RIN 0625-AA97 Import Administration; Change of Agency Name AGENCY: Import Administration, International Trade Administration, Commerce. ACTION: Final...), through internal department organizational orders, changed the name of ``Import Administration''...

  13. Preventing the acute skin side effects in patients treated with radiotherapy for breast cancer: the use of corneometry in order to evaluate the protective effect of moisturizing creams

    PubMed Central

    2013-01-01

    Background and purpose The purpose of this study was to add, to the objective evaluation, an instrumental assessment of the skin damage induced by radiation therapy. Materials and methods A group of 100 patients affected by breast cancer was recruited in the study over one year. Patients were divided into five groups of 20 patients. For each group it was prescribed a different topical treatment. The following products were used: Betaglucan, sodium hyaluronate (Neoviderm®), Vitis vinifera A. s-I-M.t-O.dij (Ixoderm®), Alga Atlantica plus Ethylbisiminomethylguaicolo and Manganese Cloruro (Radioskin1®) and Metal Esculetina plus Ginko Biloba and Aloe vera (Radioskin 2®); Natural triglycerides-fitosterols (Xderit®); Selectiose plus thermal water of Avene (Trixera+®). All hydrating creams were applied twice a day starting 15 days before and one month after treatment with radiations. Before and during treatment patients underwent weekly skin assessments and corneometry to evaluate the symptoms related to skin toxicity and state of hydration. Evaluation of acute cutaneous toxicity was defined according to the RTOG scale. Results All patients completed radiotherapy; 72% of patients presented a G1 cutaneous toxicity, 18% developed a G2 cutaneous toxicity, 10% developed a G3 toxicity, no one presented G4 toxicity. The corneometry study confirmed the protective role of effective creams used in radiation therapy of breast cancer and showed its usefulness to identify radiation-induced dermatitis in a very early stage. Conclusions The preventive use of topic products reduces the incidence of skin side effects in patients treated with radiotherapy for breast cancer. An instrumental evaluation of skin hydration can help the radiation oncologist to use strategies that prevent the onset of toxicity of high degree. All moisturizing creams used in this study were equally valid in the treatment of skin damage induced by radiotherapy. PMID:23497676

  14. 76 FR 13668 - Respiratory Protection Standard; Extension of the Office of Management and Budget's (OMB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... Act of 1995 (44 U.S.C. 3506 et seq.) and Secretary of Labor's Order No. 4-2010 (75 FR 55355). Signed... Occupational Safety and Health Administration Respiratory Protection Standard; Extension of the Office of... requirements specified by the Respiratory Protection Standard (29 CFR 1910.134). DATES: Comments must...

  15. 75 FR 22844 - Construction Fall Protection Systems Criteria and Practices and Training Requirements; Extension...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... 1995 (44 U.S.C. 3506 et seq.) and Secretary of Labor's Order No. 5-2007 (72 FR 31160). Signed at... Occupational Safety and Health Administration Construction Fall Protection Systems Criteria and Practices and... Fall Protection Systems Criteria and Practices (29 CFR 1926.502) and Training Requirements (29 CFR...

  16. Recommendations and Justifications for Modifications To Downgrade Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Field Office Federal Facility Agreement and Consent Order, Revision 1

    SciTech Connect

    Birney, Cathleen; Krauss, Mark J

    2013-10-01

    This document is part of an effort to reevaluate 37 FFACO and Administrative URs against the current Soils Risk-Based Corrective Action Evaluation Process. After reviewing 37 existing FFACO and Administrative URs, 11 URs addressed in this document have sufficient information to determine that these current URs may be downgraded to Administrative URs based on the RBCA criteria. This document presents recommendations on modifications to existing URs that will be consistent with the RBCA criteria.

  17. 40 CFR 142.24 - Administrator's rescission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Administrator's rescission. 142.24... Exemptions § 142.24 Administrator's rescission. If, upon notification of a finding by the Administrator under... revised schedule, the Administrator shall rescind the application of his finding to that...

  18. Key Obama officials leave administration

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2013-01-01

    Secretary of the Interior Ken Salazar is one of the latest members of the Obama administration to announce that he is leaving his position near the start of President Obama's second term in office. Salazar, who has served as interior secretary since January 2009, intends to leave the department by the end of March, the department noted on 16 January. Salazar joins a number of other key officials who are planning to leave the administration. They include Environmental Protection Agency administrator Lisa Jackson, National Oceanic and Atmospheric Administration administrator Jane Lubchenco, and U.S. Geological Survey director Marcia McNutt.

  19. Administrative Ecology

    ERIC Educational Resources Information Center

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  20. Administrative Support.

    ERIC Educational Resources Information Center

    Doran, Dorothy; And Others

    This guide is intended to assist business education teachers in administrative support courses. The materials presented are based on the Arizona validated occupational competencies and tasks for the occupations of receptionist, secretary, and administrative assistant. Word processing skills have been infused into each of the three sections. The…

  1. 7 CFR 1000.25 - Market administrator.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 9 2011-01-01 2011-01-01 false Market administrator. 1000.25 Section 1000.25... Rules of Practice and Procedure Governing Market Administrators § 1000.25 Market administrator. (a) Designation. The agency for the administration of the order shall be a market administrator selected by...

  2. 7 CFR 1000.25 - Market administrator.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Market administrator. 1000.25 Section 1000.25... Rules of Practice and Procedure Governing Market Administrators § 1000.25 Market administrator. (a) Designation. The agency for the administration of the order shall be a market administrator selected by...

  3. Radiation Protection Handbook

    NASA Technical Reports Server (NTRS)

    1972-01-01

    A handbook which sets forth the Kennedy Space Center radiation protection policy is presented. The book also covers administrative direction and guidance on organizational and procedural requirements of the program. Only ionizing radiation is covered.

  4. Recommendations and Justifications To Remove Use Restrictions Established under the U.S. Department of Energy, National Nuclear Security Administration Nevada Field Office Federal Facility Agreement and Consent Order, Revision 0

    SciTech Connect

    Birney, Cathleen; Krauss, Mark J

    2013-09-01

    This document is part of an effort to reevaluate 37 FFACO and Administrative URs against the current Soils Risk-Based Corrective Action Evaluation Process. After reviewing 37 existing FFACO and Administrative URs, 3 URs addressed in this document have sufficient information to determine that these current URs may be removed, based on the RBCA criteria. This document presents recommendations on modifications to existing URs that will be consistent with the RBCA criteria.

  5. 40 CFR 89.504 - Testing by the Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Testing by the Administrator. 89.504 Section 89.504 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Enforcement Auditing § 89.504 Testing by the Administrator. (a) The Administrator may require by test...

  6. 40 CFR 108.4 - Investigation by Regional Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administrator. 108.4 Section 108.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EMPLOYEE PROTECTION HEARINGS § 108.4 Investigation by Regional Administrator. Upon receipt of any request meeting the requirements of § 108.3, the Regional Administrator shall conduct a full...

  7. 40 CFR 90.504 - Testing by the Administrator.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Testing by the Administrator. 90.504 Section 90.504 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Enforcement Auditing § 90.504 Testing by the Administrator. (a) The Administrator may require by test...

  8. 37 CFR 42.54 - Protective order.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... COMMERCE TRIAL PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Trial Practice and Procedure Testimony and... Trial Practice Guide. The motion must include a certification that the moving party has in good faith... inquiry into certain matters, or limiting the scope of disclosure or discovery to certain matters;...

  9. 37 CFR 42.54 - Protective order.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... COMMERCE TRIAL PRACTICE BEFORE THE PATENT TRIAL AND APPEAL BOARD Trial Practice and Procedure Testimony and... Trial Practice Guide. The motion must include a certification that the moving party has in good faith... inquiry into certain matters, or limiting the scope of disclosure or discovery to certain matters;...

  10. 49 CFR 386.39 - Protective orders.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., including a designation of the time or place; (c) The discovery may be had only by a method of discovery... judge; or (f) A trade secret or other confidential research, development, or commercial information...

  11. 40 CFR 108.4 - Investigation by Regional Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Investigation by Regional Administrator. 108.4 Section 108.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS EMPLOYEE PROTECTION HEARINGS § 108.4 Investigation by Regional Administrator. Upon receipt of...

  12. 78 FR 72630 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263... Less Than Fair Value: Sparklers From the People's Republic of China, 56 FR 20588 (May 6, 1991), as... Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  13. 77 FR 31568 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Requests for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ... Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263... China, 56 FR 20588 (May 6, 1991), as amplified by Final Determination of Sales at Less Than Fair Value: Silicon Carbide from the People's Republic of China, 59 FR 22585 (May 2, 1994). In accordance with...

  14. 40 CFR 209.32 - Review of the administrative law judge's decision in absence of appeal.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.32 Review of the administrative law judge's decision in absence of...

  15. 40 CFR 209.32 - Review of the administrative law judge's decision in absence of appeal.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.32 Review of the administrative law judge's decision in absence of...

  16. 40 CFR 209.32 - Review of the administrative law judge's decision in absence of appeal.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.32 Review of the administrative law judge's decision in absence of...

  17. 40 CFR 209.32 - Review of the administrative law judge's decision in absence of appeal.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.32 Review of the administrative law judge's decision in absence of...

  18. 40 CFR 209.32 - Review of the administrative law judge's decision in absence of appeal.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROTECTION AGENCY (CONTINUED) NOISE ABATEMENT PROGRAMS RULES OF PRACTICE GOVERNING PROCEEDINGS UNDER THE NOISE CONTROL ACT OF 1972 Rules of Practice Governing Hearings for Orders Issued Under Section 11(d) of the Noise Control Act § 209.32 Review of the administrative law judge's decision in absence of...

  19. 78 FR 19197 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such... Sales at Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991...'s Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  20. 77 FR 52688 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263... Sales at Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991...'s Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  1. 78 FR 13631 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-28

    ...: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such... Sales at Less Than Fair Value: Sparklers From the People's Republic of China, 56 FR 20588 (May 6, 1991...'s Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  2. 78 FR 67104 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263... Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991), as... Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  3. 77 FR 65858 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-31

    ...; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such submissions are subject to... Less Than Fair Value: Sparklers From the People's Republic of China, 56 FR 20588 (May 6, 1991), as... Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  4. 76 FR 67133 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263... Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991), as... Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate-rates criteria,...

  5. 77 FR 11490 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ...: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such... concerning whether particular companies should be ``collapsed'' (i.e., treated as a single entity for... conduct collapsing analyses at the respondent selection phase of this review and will not...

  6. 77 FR 77017 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ...: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such...'') countries, the Department begins with a rebuttable presumption that all companies within the country are... an NME country this single rate unless an exporter can demonstrate that it is...

  7. 78 FR 79392 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... Tjiwi Kimia, Tbk PT. Pindo Deli Pulp and Paper Mills PT. Indah Kiat Pulp and Paper, Tbk The People's... Huasheng Paper Co., Ltd. Hainan Jinhai Pulp & Paper Co., Ltd. Ningbo Asia Pulp & Paper Co., Ltd. Ningbo... Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR...

  8. 77 FR 4759 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Requests for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such... Sales at Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991...'s Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  9. 77 FR 71575 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ...; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such submissions are subject to... Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991), as... Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  10. 77 FR 59168 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... Countervailing Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR... Sales at Less Than Fair Value: Sparklers from the ] People's Republic of China, 56 FR 20588 (May 6, 1991...'s Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  11. 76 FR 61076 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Requests for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ...: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such... Sales at Less Than Fair Value: Sparklers From the People's Republic of China, 56 FR 20588 (May 6, 1991...'s Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate-rates criteria,...

  12. 78 FR 60834 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ...; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such submissions are subject to... Sales at Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991...'s Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  13. 76 FR 53404 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Requests for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ...; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such submissions are subject to... Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991), as... Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate-rates criteria,...

  14. 78 FR 6291 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ...; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Such submissions are subject to... Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6, 1991), as... Republic of China, 59 FR 22585 (May 2, 1994). In accordance with the separate rates criteria,...

  15. 19 CFR Annex II to Part 351 - Deadlines for Parties in Countervailing Administrative Reviews

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... questionnaire 351.301(c)(2)(iv) (14 days after date of receipt of initial questionnaire) 75 days Application for an administrative protective order 351.305(b)(3) 90 days 3 Questionnaire response 351.301(c)(2)(iii) (At least 30 days after date of receipt of initial questionnaire) 120 days Withdrawal of request...

  16. 76 FR 82268 - Initiation of Antidumping and Countervailing Duty Administrative Reviews and Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-30

    ... Huaguang Food Import & Export Co., Ltd. Jinxiang Dacheng Food Co., Ltd. Jinxiang Dongyun Freezing Storage... Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263... Sales at Less Than Fair Value: Sparklers from the People's Republic of China, 56 FR 20588 (May 6,...

  17. 40 CFR Appendix A to Part 112 - Memorandum of Understanding Between the Secretary of Transportation and the Administrator of the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Secretary of Transportation and the Administrator of the Environmental Protection Agency A Appendix A to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... the Secretary of Transportation and the Administrator of the Environmental Protection Agency...

  18. 40 CFR Appendix A to Part 112 - Memorandum of Understanding Between the Secretary of Transportation and the Administrator of the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Secretary of Transportation and the Administrator of the Environmental Protection Agency A Appendix A to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... the Secretary of Transportation and the Administrator of the Environmental Protection Agency...

  19. 40 CFR Appendix A to Part 112 - Memorandum of Understanding Between the Secretary of Transportation and the Administrator of the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Secretary of Transportation and the Administrator of the Environmental Protection Agency A Appendix A to Part 112 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS OIL... Secretary of Transportation and the Administrator of the Environmental Protection Agency section...

  20. Administrative IT

    ERIC Educational Resources Information Center

    Grayson, Katherine, Ed.

    2006-01-01

    When it comes to Administrative IT solutions and processes, best practices range across the spectrum. Enterprise resource planning (ERP), student information systems (SIS), and tech support are prominent and continuing areas of focus. But widespread change can also be accomplished via the implementation of campuswide document imaging and sharing,…

  1. Database Administrator

    ERIC Educational Resources Information Center

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  2. ADMINISTRATIVE CLIMATE.

    ERIC Educational Resources Information Center

    BRUCE, ROBERT L.; CARTER, G.L., JR.

    IN THE COOPERATIVE EXTENSION SERVICE, STYLES OF LEADERSHIP PROFOUNDLY AFFECT THE QUALITY OF THE SERVICE RENDERED. ACCORDINGLY, MAJOR INFLUENCES ON ADMINISTRATIVE CLIMATE AND EMPLOYEE PRODUCTIVITY ARE EXAMINED IN ESSAYS ON (1) SOURCES OF JOB SATISFACTION AND DISSATISFACTION, (2) MOTIVATIONAL THEORIES BASED ON JOB-RELATED SATISFACTIONS AND NEEDS,…

  3. Engineering Administration.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    This book is intended to acquaint naval engineering officers with their duties in the engineering department. Standard shipboard organizations are analyzed in connection with personnel assignments, division operations, and watch systems. Detailed descriptions are included for the administration of directives, ship's bills, damage control, training…

  4. 76 FR 54735 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-02

    ... Antidumping Duties, 68 FR 23954 (May 6, 2003), the Department has clarified its practice with respect to the... Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Further, in...-570-954........ 3/12/10-8/31/11 Foundry Coke, A-570-862 9/1/10-8/31/11 Freshwater Crawfish Tail...

  5. 78 FR 54235 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-03

    ... Antidumping Duties, 68 FR 23954 (May 6, 2003), and Non- Market Economy Antidumping Proceedings: Assessment of Antidumping Duties, 76 FR 65694 ] (October 24, 2011) the Department has clarified its practice with respect to...: Electronic Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011)....

  6. 78 FR 72636 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ...: Assessment of Antidumping Duties, 68 FR 23954 (May 6, 2003), and Non- Market Economy Antidumping Proceedings: Assessment of Antidumping Duties, 76 FR 65694 (October 24, 2011) the Department has clarified its practice... Countervailing Duty Proceedings: Electronic Filing Procedures; Administrative Protective Order Procedures, 76...

  7. 76 FR 74773 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... explained in Antidumping and Countervailing Duty Proceedings: Assessment of Antidumping Duties, 68 FR 23954...; Administrative Protective Order Procedures, 76 FR 39263 (July 6, 2011). Further, in accordance with 19 CFR 351...: Certain Preserved Mushrooms, A-337-804........ 12/1/10-11/30/11 India: Carbazole Violet Pigment 23,...

  8. 15 CFR Supplement No. 1 to Part 764 - Standard Terms of Orders Denying Export Privileges

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Export Privileges No. Supplement No. 1 to Part 764 Commerce and Foreign Trade Regulations Relating to... ADMINISTRATION REGULATIONS ENFORCEMENT AND PROTECTIVE MEASURES Pt. 764, Supp. 1 Supplement No. 1 to Part 764... “standard” or “non-standard.” This Supplement specifies terms of the standard order denying export...

  9. 15 CFR Supplement No. 1 to Part 764 - Standard Terms of Orders Denying Export Privileges

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Export Privileges No. Supplement No. 1 to Part 764 Commerce and Foreign Trade Regulations Relating to... ADMINISTRATION REGULATIONS ENFORCEMENT AND PROTECTIVE MEASURES Pt. 764, Supp. 1 Supplement No. 1 to Part 764... “standard” or “non-standard.” This supplement specifies terms of the standard order denying export...

  10. 15 CFR Supplement No. 1 to Part 764 - Standard Terms of Orders Denying Export Privileges

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Export Privileges No. Supplement No. 1 to Part 764 Commerce and Foreign Trade Regulations Relating to... ADMINISTRATION REGULATIONS ENFORCEMENT AND PROTECTIVE MEASURES Pt. 764, Supp. 1 Supplement No. 1 to Part 764... “standard” or “non-standard.” This Supplement specifies terms of the standard order denying export...

  11. 15 CFR Supplement No. 1 to Part 764 - Standard Terms of Orders Denying Export Privileges

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Export Privileges No. Supplement No. 1 to Part 764 Commerce and Foreign Trade Regulations Relating to... ADMINISTRATION REGULATIONS ENFORCEMENT AND PROTECTIVE MEASURES Pt. 764, Supp. 1 Supplement No. 1 to Part 764... “standard” or “non-standard.” This Supplement specifies terms of the standard order denying export...

  12. 15 CFR Supplement No. 1 to Part 764 - Standard Terms of Orders Denying Export Privileges

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Export Privileges No. Supplement No. 1 to Part 764 Commerce and Foreign Trade Regulations Relating to... ADMINISTRATION REGULATIONS ENFORCEMENT AND PROTECTIVE MEASURES Pt. 764, Supp. 1 Supplement No. 1 to Part 764... “standard” or “non-standard.” This Supplement specifies terms of the standard order denying export...

  13. 77 FR 83 - Antidumping or Countervailing Duty Order, Finding, or Suspended Investigation; Opportunity To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-03

    ... Antidumping Duties, 68 FR 23954 (May 6, 2003), the Department has clarified its practice with respect to the... Filing Procedures; Administrative Protective Order Procedures, 76 FR 39263, (July 6, 2011). Further, in..., A-570-873 1/1/11-12/31/11 Folding Gift Boxes, A-570-866 1/1/11-12/31/11 Potassium Permanganate,...

  14. The School Administrator's Publicity Handbook, with 74 Story Ideas in Handy Checkoff Format. Internal and External PR for Maximum Media Exposure and an Orderly System for Setting Up the Program. Operations Notebook 5.

    ERIC Educational Resources Information Center

    Association of California School Administrators, 1973

    1973-01-01

    This booklet presents brief, detailed guidelines intended to aid school administrators in developing and managing a publicity program for schools. Primary emphasis of the discussion is on generating publicity and media exposure; only cursory attention is devoted to the other facets of a complete public relations program. Major topics of discussion…

  15. System Administrator for LCS Development Sets

    NASA Technical Reports Server (NTRS)

    Garcia, Aaron

    2013-01-01

    The Spaceport Command and Control System Project is creating a Checkout and Control System that will eventually launch the next generation of vehicles from Kennedy Space Center. KSC has a large set of Development and Operational equipment already deployed in several facilities, including the Launch Control Center, which requires support. The position of System Administrator will complete tasks across multiple platforms (Linux/Windows), many of them virtual. The Hardware Branch of the Control and Data Systems Division at the Kennedy Space Center uses system administrators for a variety of tasks. The position of system administrator comes with many responsibilities which include maintaining computer systems, repair or set up hardware, install software, create backups and recover drive images are a sample of jobs which one must complete. Other duties may include working with clients in person or over the phone and resolving their computer system needs. Training is a major part of learning how an organization functions and operates. Taking that into consideration, NASA is no exception. Training on how to better protect the NASA computer infrastructure will be a topic to learn, followed by NASA work polices. Attending meetings and discussing progress will be expected. A system administrator will have an account with root access. Root access gives a user full access to a computer system and or network. System admins can remove critical system files and recover files using a tape backup. Problem solving will be an important skill to develop in order to complete the many tasks.

  16. 40 CFR 179.130 - Administrative record.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Administrative record. 179.130 Section 179.130 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) PESTICIDE PROGRAMS...) of this chapter to which the objection related, and: (i) The regulation or petition denial that...

  17. 40 CFR 35.6815 - Administrative requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... services to individuals, such as pipes, lines, or pumps providing hookups for homeowners on an existing... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Administrative requirements. 35.6815 Section 35.6815 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER...

  18. 40 CFR 35.6815 - Administrative requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... services to individuals, such as pipes, lines, or pumps providing hookups for homeowners on an existing... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Administrative requirements. 35.6815 Section 35.6815 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER...

  19. 5 CFR 362.101 - Program administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Program administration. 362.101 Section 362.101 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PATHWAYS PROGRAMS General Provisions § 362.101 Program administration. (a) The Pathways Programs authorized under Executive Order 13562 consist of the...

  20. 7 CFR 1280.603 - Administrator, FSA.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administrator, FSA. 1280.603 Section 1280.603... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.603 Administrator, FSA. Administrator, FSA, means the Administrator, of the Farm Service Agency, or any officer or employee of USDA to...

  1. 7 CFR 1280.602 - Administrator, AMS.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Administrator, AMS. 1280.602 Section 1280.602... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.602 Administrator, AMS. Administrator, AMS, means the Administrator of the Agricultural Marketing Service, or any officer or employee of...

  2. 48 CFR 243.204 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Administration. 243.204... OF DEFENSE CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 243.204 Administration. Follow the procedures at PGI 243.204 for administration of change orders....

  3. 77 FR 20641 - Jose Concepcion: Debarment Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    ... HUMAN SERVICES Food and Drug Administration Jose Concepcion: Debarment Order AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is issuing an order under the Federal Food, Drug, and Cosmetic Act (the FD&C Act) debarring Jose Concepcion for 5 years...

  4. 75 FR 17927 - Kevin Xu: Debarment Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... goods, namely pharmaceutical drugs, and knowingly used a counterfeit mark, the ZYPREXA trademark, on and... HUMAN SERVICES Food and Drug Administration Kevin Xu: Debarment Order AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is issuing an order...

  5. Criminal law repercussions on the Civil Protection System

    NASA Astrophysics Data System (ADS)

    Altamura, M.; Musso, L.

    2009-09-01

    The legal systems of our Countries provide the citizenship with a high level of protection. Personal safety and the protection of property are guaranteed by the State through organized structures among which we can include the Civil Protection. The progress of science and technology has greatly improved monitoring tools, currently used by the Civil Protection, which allow, to a certain extent, to predict and prevent risk and natural hazards. The assertion of an individual right, which in some cases has reached a constitutional rank, to benefit from Civil Protection services and the widespread perception throughout the citizenship of the competence of the system to prevent disasters, often causes people to take legal action against Civil Protection authorities should they fail in their duties to protect. However, the attempt of having both recognized an economic compensation for the suffered loss and the punishment of those whom misled, frequently undergoes criminal law. This process could have results that may jeopardize the effectiveness of Civil Protection service without meeting citizens’ demands. A dual effort is thus necessary in order to solve such a problem. On the one hand, an interdisciplinary knowledge needs to pervade criminal law in an attempt to relieve its self-referentiality and pretended supremacy. On the other hand an alternative, and more agile, system -such as civil or administrative law- has to be identified in order to respond to the legitimate requests for protection in the case of a faulty behaviour of the authorities.

  6. 5 CFR 353.302 - Retention protections.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Retention protections. 353.302 Section 353.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RESTORATION... protections. An injured employee enjoys no special protection in a reduction in force. Separation by...

  7. 5 CFR 353.302 - Retention protections.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Retention protections. 353.302 Section 353.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RESTORATION... protections. An injured employee enjoys no special protection in a reduction in force. Separation by...

  8. 5 CFR 353.302 - Retention protections.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Retention protections. 353.302 Section 353.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RESTORATION... protections. An injured employee enjoys no special protection in a reduction in force. Separation by...

  9. 5 CFR 353.302 - Retention protections.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Retention protections. 353.302 Section 353.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RESTORATION... protections. An injured employee enjoys no special protection in a reduction in force. Separation by...

  10. 5 CFR 353.302 - Retention protections.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Retention protections. 353.302 Section 353.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS RESTORATION... protections. An injured employee enjoys no special protection in a reduction in force. Separation by...

  11. 40 CFR 1.23 - Office of the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Office of the Administrator. 1.23... AND GENERAL INFORMATION Headquarters § 1.23 Office of the Administrator. The Environmental Protection Agency is headed by an Administrator who is appointed by the President, by and with the consent of...

  12. Administrative Careers Serving the Environment.

    ERIC Educational Resources Information Center

    Environmental Protection Agency, Washington, DC.

    This guide was developed by the Environmental Protection Agency (EPA) to provide individual with information about potential administrative careers with the agency. The brochure's introduction presents an overview of the EPA and its involvement in setting environmental standards, standards enforcement and monitoring, and future trends in…

  13. Software Solutions for Better Administration.

    ERIC Educational Resources Information Center

    Kazanjian, Edward

    1997-01-01

    The CO/OP (founded in 1973 as the Massachusetts Association of School Business Officials Cooperative Corporation) has created and produced administrative software for schools. Describes two areas in which software can increase revenue and provide protection for personnel: (1) invoice/accounts receivable for the rental of school space; and (2) an…

  14. 49 CFR 1502.1 - Responsibilities of the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... responsible for the planning, direction, and control of the Transportation Security Administration (TSA) and..., officials designated by TSA's internal order on succession shall serve as Acting Deputy Administrator...

  15. 40 CFR 72.96 - Administrator's action on compliance certifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Administrator's action on compliance certifications. 72.96 Section 72.96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Compliance Certification § 72.96 Administrator's action on compliance certifications. (a)...

  16. 40 CFR 86.1107-87 - Testing by the Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 20 2013-07-01 2013-07-01 false Testing by the Administrator. 86.1107-87 Section 86.1107-87 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... manufacturer conform with the regulations of this subpart. (b)(1) Whenever the Administrator conducts a test...

  17. 40 CFR 231.6 - Administrator's final determinations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 25 2014-07-01 2014-07-01 false Administrator's final determinations. 231.6 Section 231.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING SECTION 404(c) PROCEDURES § 231.6 Administrator's final determinations. After reviewing...

  18. 40 CFR 231.6 - Administrator's final determinations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Administrator's final determinations. 231.6 Section 231.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING SECTION 404(c) PROCEDURES § 231.6 Administrator's final determinations. After reviewing...

  19. 40 CFR 72.96 - Administrator's action on compliance certifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Administrator's action on compliance certifications. 72.96 Section 72.96 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Compliance Certification § 72.96 Administrator's action on compliance certifications. (a)...

  20. 40 CFR 27.44 - Right to administrative offset.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Right to administrative offset. 27.44 Section 27.44 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROGRAM FRAUD CIVIL REMEDIES § 27.44 Right to administrative offset. The amount of any penalty or assessment which has...