Sample records for administrator michael griffin

  1. Michael Griffin Senate Confirmation Hearing

    NASA Image and Video Library

    2005-04-12

    Dr. Michael Griffin, right, talks with his wife Rebecca Griffin prior to testifying at his confirmation hearing before the U.S. Senate Commerce Committee, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit (NASA/Renee Bouchard)

  2. Michael Griffin Senate Confirmation Hearing

    NASA Image and Video Library

    2005-04-12

    U.S. Senator Barbara Mikulski, D-Md., testifies before the U.S. Senate Commerce Committee during the confirmation hearing of Dr. Michael Griffin, rear center, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. Griffin currently heads the space department at Johns Hopkins University's Applied Physics Laboratory. If confirmed by the full U.S. Senate, Dr. Griffin would be NASA's 11th administrator. Photo Credit: (NASA/Renee Bouchard)

  3. Michael Griffin Senate Confirmation Hearing

    NASA Image and Video Library

    2005-04-11

    U.S. Senator Barbara Mikulski, D-Md., testifies before the U.S. Senate Commerce Committee during the confirmation hearing of Dr. Michael Griffin, rear center, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. Griffin currently heads the space department at Johns Hopkins University's Applied Physics Laboratory. If confirmed by the full U.S. Senate, Dr. Griffin would be NASA's 11th administrator. Photo Credit: (NASA/Renee Bouchard)

  4. Michael Griffin Senate Confirmation Hearing

    NASA Image and Video Library

    2005-04-12

    U.S. Senator Barbara Mikulski, D-Md., left, talks with Michael Griffin as Senator Kay Bailey Hutchison, R-Tx., and Griffin's wife Rebecca look on prior to his testimony, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit: (NASA/Renee Bouchard)

  5. Michael Griffin Senate Confirmation Hearing

    NASA Image and Video Library

    2005-04-12

    U.S. Senator Barbara Mikulski, D-Md., testifies before the U.S. Senate Commerce Committee during the confirmation hearing of Dr. Michael Griffin, right background, Tuesday, April 12, 2005, at the Russell Senate Office Building in Washington. Griffin currently heads the space department at Johns Hopkins University's Applied Physics Laboratory. If confirmed by the full U.S. Senate, Dr. Griffin would be NASA's 11th administrator. Photo Credit: (NASA/Renee Bouchard)

  6. Michael Griffin Senate Confirmation Hearing

    NASA Image and Video Library

    2005-04-12

    Dr. Michael Griffin testifies, Tuesday, April 12, 2005, during his confirmation hearing before the U.S. Senate Commerce Committee at the Russell Senate Office Building in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit (NASA/Renee Bouchard)

  7. Michael Griffin Senate Confirmation Hearing

    NASA Image and Video Library

    2005-04-11

    Dr. Michael Griffin testifies, Tuesday, April 12, 2005, during his confirmation hearing before the U.S. Senate Commerce Committee at the Russell Senate Office Building in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit (NASA/Renee Bouchard)

  8. Michael Griffin Senate Confirmation Hearing

    NASA Image and Video Library

    2005-04-12

    U.S. Senator Daniel K. Inouye, D-Hawaii, left, speaks as U.S. Senator Ted Stevens, R-Alaska, looks on during the confirmation hearing for Dr. Michael Griffin, in front of the U.S. Senate Commerce Committee, Tuesday, April 12, 2005, in Washington. If confirmed, Griffin, who currently heads the space department at the Johns Hopkins University Applied Physics Laboratory will become NASA's 11th administrator. Photo Credit (NASA/Renee Bouchard)

  9. Michael Griffin Senate Hearing

    NASA Image and Video Library

    2005-05-17

    NASA Administrator Dr. Michael Griffin speaks in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

  10. Michael Griffin Senate Hearing

    NASA Image and Video Library

    2005-05-17

    NASA Administrator Dr. Michael Griffin is seen during his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

  11. Michael Griffin Senate Hearing

    NASA Image and Video Library

    2005-05-17

    NASA Administrator Dr. Michael Griffin smiles during his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

  12. Michael Griffin Senate Hearing

    NASA Image and Video Library

    2005-05-17

    NASA Administrator Dr. Michael Griffin delivers a statement during testimony in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

  13. Michael Griffin House Science Committee Hearing

    NASA Image and Video Library

    2005-06-27

    NASA Administrator Michael Griffin prepares to testify at a hearing before the House Science Committee, Tuesday, June 28, 2005, Rayburn House Office building, Washington. Photo Credit: (NASA/Bill Ingalls)

  14. Michael Griffin Senate Hearing

    NASA Image and Video Library

    2005-05-17

    NASA Administrator Dr. Michael Griffin is seen prior to his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

  15. Michael Griffin House Science Committee Hearing

    NASA Image and Video Library

    2005-06-27

    Rep. Bart Gordon, D-TN., questions NASA Administrator Michael Griffin during a House Science Committee hearing, Tuesday, June 28, 2005, Rayburn House Office building, Washington. Photo Credit: (NASA/Bill Ingalls)

  16. Michael Griffin Senate Hearing

    NASA Image and Video Library

    2005-05-17

    Senator Trent Lott, R-Miss., questions NASA Administrator Dr. Michael Griffin during his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

  17. Michael Griffin Oath Of Office

    NASA Image and Video Library

    2005-04-14

    John H. Marburger, Science Adviser to the President and Director of the Office of Science and Technology Policy (OSTP), left, shakes hands with NASA Administrator Michael Griffin following his swearing-in, Thursday, April 14, 2005, in Washington. Photo Credit: (NASA/Renee Bouchard)

  18. Michael Griffin Senate Hearing

    NASA Image and Video Library

    2005-05-17

    U.S. Senator Bill Nelson. R-Fla., questions NASA Administrator Dr. Michael Griffin during his appearance in front of the Senate Commerce Committee Science and Space Subcommittee hearing on Human Space Flight: The Space Shuttle and Beyond, Wednesday, May 18, 2005, in the Russell Senate Office Building on Capitol Hill in Washington. Photo Credit: (NASA/Bill Ingalls)

  19. Michael Griffin House Science Committee Hearing

    NASA Image and Video Library

    2005-06-27

    Members of the media photograph NASA Administrator Michael Griffin as he testifies at a hearing before the House Science Committee, Tuesday, June 28, 2005, Rayburn House Office building, Washington. Photo Credit: (NASA/Bill Ingalls)

  20. Michael Griffin Oath Of Office

    NASA Image and Video Library

    2005-04-14

    John H. Marburger, Science Adviser to the President and Director of the Office of Science and Technology Policy (OSTP), left, talks with NASA Administrator Michael Griffin, center, while his wife Rebecca and daughter Katie look on following his swearing-in, Thursday, April 14, 2005, in Washington. Photo Credit: (NASA/Renee Bouchard)

  1. Michael Griffin Meets with Elon Musk

    NASA Image and Video Library

    2005-04-19

    NASA Administrator Michael Griffin, left, meets with CEO of SpaceX Elon Musk, right, Wednesday, April 20, 2005 at NASA Headquarters in Washington. Looking on in the background are Larry Williams, NASA astronaut Marsha Ivins and NASA manager Christopher Shank. Photo Credit: (NASA/Renee Bouchard)

  2. Michael Griffin Oath Of Office

    NASA Image and Video Library

    2005-04-14

    NASA Administrator Michael Griffin, left, is administered the oath of office by John H. Marburger, right, Science Adviser to the President and Office of Science and Technology Policy Director, during a private ceremony at the Old Executive Office Building, Thursday, April 14, 2005, in Washington, while his wife Rebecca and daughter Katie look on. Photo Credit: (NASA/Renee Bouchard)

  3. Michael Griffin Discusses Exploration Architecture Study

    NASA Image and Video Library

    2005-09-18

    NASA Administrator Michael Griffin discusses the results of the agency's exploration architecture study on Monday, Sept. 19, 2005, at NASA Headquarters in Washington. The study made specific design recommendations for a vehicle to carry crews into space, a family of launch vehicles to take missions to the moon and beyond, and a "lunar mission architecture" for landing on the moon. Photo Credit: (NASA/Bill Ingalls)

  4. Griffin Lifts Off at NASA With Calls for Speeding Shuttle Replacement, Reopening Hubble Decision

    NASA Technical Reports Server (NTRS)

    Morring, Frank, Jr.

    2005-01-01

    Michael D. Griffin launched his tenure as NASA's 11th administrator on a fast track, using his "emergency" confiimation by the U.S. Senate to plug himself into space shuttle return-to-flight decision-making and urging faster development of the shuttle replacement. He also deftly sidestepped the treacherous issue of letting the aging Hubble Space Telescope die that was left behind by former Administrator Sean O'Keefe. Griffin told the Senate Commerce, Science and Transportation Committee that he would take another look at a shuttle mission to service the telescope, but not until the redesigned shuttle system makes a couple of test flights. Griffin made clear at his confirmation hearing Apr. 12 that he has long supported the ideas embodied in President Bush s push to move human exploration out of low Earth orbit, while finishing the International Space Station and retiring the space shuttle as soon as possible. And he showed right out of the blocks that his technical training and management background should serve him well in implementing Bush's directives.

  5. 78 FR 25382 - Amendment of Class E Airspace; Griffin, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-01

    ... County Airport, Griffin, GA (Lat. 33[deg]13'37'' N., long. 84[deg]16'30'' W.) That airspace extending...-1219; Airspace Docket No. 12-ASO-43] Amendment of Class E Airspace; Griffin, GA AGENCY: Federal... Griffin, GA, as the Griffin Non-Directional Beacon (NDB) has been decommissioned and new Standard...

  6. 78 FR 6261 - Proposed Amendment of Class E Airspace; Griffin, GA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... Airport, Griffin, GA (Lat. 33[deg]13'37'' N., long. 84[deg]16'30'' W.) That airspace extending upward from...-1219; Airspace Docket No. 12-ASO-43] Proposed Amendment of Class E Airspace; Griffin, GA AGENCY... action proposes to amend Class E Airspace at Griffin, GA, as the Griffin Non-Directional Beacon (NDB) has...

  7. Trent Griffin honored on Good Morning America

    NASA Image and Video Library

    2015-09-17

    TRENT GRIFFIN, RIGHT, IS CONGRATULATED FOR HIS WORK IN THE COMMUNITY AND HIS OUTREACH EFFORTS TO ENCOURAGE STUDENTS TO ENTER THE SCIENCE, TECHNOLOGY, ENGINEERING AND MATH FIELDS BY MARSHALL CENTER DIRECTOR PATRICK SCHEUERMANN. GRIFFIN WAS FEATURED AS A HOMETOWN HERO ON ABC’S "GOOD MORNING AMERICA" AT THE U.S. SPACE & ROCKET CENTER.

  8. KSC-05PD-1041

    NASA Technical Reports Server (NTRS)

    2005-01-01

    KENNEDY SPACE CENTER, FLA. In Orbiter Processing Facility bay 1, NASA Administrator Michael Griffin observes as technicians prepare Space Shuttle Atlantis for the second Return to Flight mission, STS-121. This is Griffin's first official visit to Kennedy Space Center. Griffin is the 11th administrator of NASA, a role he assumed on April 14, 2005. Griffin was nominated to the position in March while serving as the Space Department head at Johns Hopkins University's Applied Physics Laboratory in Baltimore. A registered professional engineer in Maryland and California, Griffin served as chief engineer at NASA earlier in his career. He holds numerous scientific and technical degrees including a Ph.D. in Aerospace Engineering from the University of Maryland.

  9. Michael Griffin | NREL

    Science.gov Websites

    production of high-value products Physical and chemical material characterization under reaction conditions Heterogeneous catalysis Design and operation of reactor systems Analysis of reaction kinetics and mechanisms labeled "major reaction products" at the top. On the right is a figure of blue spheres with a

  10. Alligator diet in relation to alligator mortality on Lake Griffin, FL

    USGS Publications Warehouse

    Rice, A.N.; Ross, J.P.; Woodward, A.R.; Carbonneau, D.A.; Percival, H.F.

    2007-01-01

    Alligator mississippiensis (American Alligators) demonstrated low hatch-rate success and increased adult mortality on Lake Griffin, FL, between 1998 and 2003. Dying Lake Griffin alligators with symptoms of poor motor coordination were reported to show specific neurological impairment and brain lesions. Similar lesions were documented in salmonines that consumed clupeids with high thiaminase levels. Therefore, we investigated the diet of Lake Griffin alligators and compared it with alligator diets from two lakes that exhibited relatively low levels of unexplained alligator mortality to see if consumption of Dorosoma cepedianum (gizzard shad) could be correlated with patterns of mortality. Shad in both lakes Griffin and Apopka had high levels of thiaminase and Lake Apopka alligators were consuming greater amounts of shad relative to Lake Griffin without showing mortality rates similar to Lake Griffin alligators. Therefore, a relationship between shad consumption alone and alligator mortality is not supported.

  11. KSC-05PD-1048

    NASA Technical Reports Server (NTRS)

    2005-01-01

    KENNEDY SPACE CENTER, FLA. Michael Griffin (left), administrator of the National Aeronautics and Space Administration (NASA), and James Kennedy, director of the John F. Kennedy Space Center (KSC), address KSC employees during a Town Hall meeting. The meeting was held in the Training Auditorium and broadcast around the Center to employees not in attendance. This is Griffin's first official visit to Kennedy Space Center. Griffin is the 11th administrator of NASA, a role he assumed on April 14, 2005. Griffin was nominated to the position in March while serving as the Space Department head at Johns Hopkins University's Applied Physics Laboratory in Baltimore. A registered professional engineer in Maryland and California, Griffin served as chief engineer at NASA earlier in his career. He holds numerous scientific and technical degrees including a Ph.D. in Aerospace Engineering from the University of Maryland.

  12. KSC-05PD-1040

    NASA Technical Reports Server (NTRS)

    2005-01-01

    KENNEDY SPACE CENTER, FLA. NASA Administrator Michael Griffin (left) tours Orbiter Processing Facility bay 1 where Space Shuttle Atlantis is currently being processed for the second Return to Flight mission, STS-121. He is accompanied by NASA ground systems engineer Doug Moore. This is Griffin's first official visit to Kennedy Space Center. Griffin is the 11th administrator of NASA, a role he assumed on April 14, 2005. Griffin was nominated to the position in March while serving as the Space Department head at Johns Hopkins University's Applied Physics Laboratory in Baltimore. A registered professional engineer in Maryland and California, Griffin served as chief engineer at NASA earlier in his career. He holds numerous scientific and technical degrees including a Ph.D. in Aerospace Engineering from the University of Maryland.

  13. Fiscal Year 2007 Budget Press Conference

    NASA Image and Video Library

    2006-02-06

    NASA Administrator Michael Griffin outlines the President's budget for fiscal year 2007 during a news conference, Monday, Feb. 6, 2006, at NASA Headquarters in Washington. Griffin was joined by the heads of NASA's four mission directorates to explain how the proposed $16.8 billion dollar budget supports the Vision for Space Exploration. Seated left to right: Scott Horowitz, NASA Associate Administrator for Exploration Systems, William Gerstenmaier, NASA Associate Administrator for Space Operations, Lisa Porter, NASA Associate Administrator for Aeronautics Research and Mary Cleave, NASA Associate Administrator for Science. Photo Credit: (NASA/Bill Ingalls)

  14. Griffin: A Tool for Symbolic Inference of Synchronous Boolean Molecular Networks.

    PubMed

    Muñoz, Stalin; Carrillo, Miguel; Azpeitia, Eugenio; Rosenblueth, David A

    2018-01-01

    Boolean networks are important models of biochemical systems, located at the high end of the abstraction spectrum. A number of Boolean gene networks have been inferred following essentially the same method. Such a method first considers experimental data for a typically underdetermined "regulation" graph. Next, Boolean networks are inferred by using biological constraints to narrow the search space, such as a desired set of (fixed-point or cyclic) attractors. We describe Griffin , a computer tool enhancing this method. Griffin incorporates a number of well-established algorithms, such as Dubrova and Teslenko's algorithm for finding attractors in synchronous Boolean networks. In addition, a formal definition of regulation allows Griffin to employ "symbolic" techniques, able to represent both large sets of network states and Boolean constraints. We observe that when the set of attractors is required to be an exact set, prohibiting additional attractors, a naive Boolean coding of this constraint may be unfeasible. Such cases may be intractable even with symbolic methods, as the number of Boolean constraints may be astronomically large. To overcome this problem, we employ an Artificial Intelligence technique known as "clause learning" considerably increasing Griffin 's scalability. Without clause learning only toy examples prohibiting additional attractors are solvable: only one out of seven queries reported here is answered. With clause learning, by contrast, all seven queries are answered. We illustrate Griffin with three case studies drawn from the Arabidopsis thaliana literature. Griffin is available at: http://turing.iimas.unam.mx/griffin.

  15. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin testifies as NASA Deputy Administrator Shana Dale looks on during a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  16. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin, left, testifies as NASA Deputy Administrator Shana Dale looks during a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  17. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin, left, and NASA Deputy Administrator Shana Dale share a laugh during a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  18. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin, left, testifies as NASA Deputy Administrator Shana Dale looks on during a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  19. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin, left, and NASA Deputy Administrator Shana Dale testify in front of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  20. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Deputy Administrator Shana Dale, right, speaks as NASA Administrator Michael Griffin looks on during a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  1. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin is seen through a television camera at a NASA Update announcing to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Griffin was joined by Scott J. Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right. Dean Acosta, NASA Deputy Assistant Administrator and Press Secretary, far left, moderates the program. Photo Credit: (NASA/Bill Ingalls)

  2. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin testifies during a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  3. New Opportunities in Decay Spectroscopy with the GRIFFIN and DESCANT Arrays

    NASA Astrophysics Data System (ADS)

    Bildstein, V.; Andreoiu, C.; Ball, G. C.; Ballast, T.; Bartlett, C.; Bender, P. C.; Bernier, N.; Bianco, L.; Bishop, D.; Brennan, D.; Bruhn, T.; Cheeseman, A.; Churchman, R.; Ciccone, S.; Davids, B.; Demand, G.; Dillmann, I.; Garnsworthy, A. B.; Garrett, P. E.; Georges, S.; Hackman, G.; Hadinia, B.; Kokke, R.; Krücken, R.; Linn, Y.; Lim, C.; Martin, J.-P.; Miller, D.; Mills, W. J.; Morrison, L. N.; Ohlmann, C. A.; Park, J.; Pearson, C. J.; Pore, J. L.; Rajabali, M. M.; Rand, E. T.; Rizwan, U.; Sarazin, F.; Shaw, B.; Starosta, K.; Svensson, C. E.; Sumithrarachchi, C.; Unsworth, C.; Voss, P.; Wang, Z. M.; Williams, J.; Wong, J.; Wong, S.

    The GRIFFIN (Gamma-Ray Infrastructure For Fundamental Investigations of Nuclei) project is a major upgrade of the decay spectroscopy capabilities at TRIUMF-ISAC. GRIFFIN will replace the 8π spectrometer with an array of up to 16 large-volume HPGe clover detectors and use a state-of-the-art digital data acquisition system. The existing ancillary detector systems that had been developed for 8π, such as the SCEPTAR array for β-tagging, PACES for high-resolution internal conversion electron spectroscopy, and the DANTE array of LaBr3/BaF2 scintillators for fast γ-ray timing, will be used with GRIFFIN. GRIFFIN can also accommodate the new neutron detector array DESCANT (Deuterated Scintillator Array for Neutron Tagging), enabling the study of β-delayed neutron emitters. DESCANT consists of up to 70 detectors, each filled with approximately 2 liters of deuterated benzene, a liquid scintillator that provides pulse-shape discrimination (PSD) capabilities to distinguish between neutrons and γ-rays interacting with the detector. In addition, the anisotropic nature of n-d scattering as compared to the isotropic n-p scattering allows for the determination of the neutron energy spectrum directly from the pulse-height spectrum, complementing the time-of-flight (TOF) information. The installation of GRIFFIN is under way and first experiments are planned for the fall of 2014. The array will be completed in 2015 with the full complement of 16 clovers. DESCANT will be tested coupled with GRIFFIN in spring of 2015.

  4. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin, left, and NASA Deputy Administrator Shana Dale talk prior to the start of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  5. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin, right, and Brian Chase, NASA's Assistant Administrator for Legislative Affairs confer prior to the start of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  6. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    Dean Acosta, NASA Deputy Assistant Administrator and Press Secretary, left, moderates a NASA Update with NASA Administrator Michael Griffin, Scott J. Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right, on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  7. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    Dean Acosta, NASA Deputy Assistant Administrator and Press Secretary, left, moderates a NASA Update with NASA Administrator Michael Griffin, second from left, Scott J. Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right, on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  8. NASA Agency Overview Briefing

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The briefing opened with Dean Acosta (NASA Press Secretary) introducing Michael Griffin (NASA Administrator) and Bill Gerstenmaier (Associate Administrator for Space Operations). Bill Griffin stated that they would resume the Shuttle Fight to Return process, that the vehicle was remarkably clean and if the weather was good, the Shuttle would be ready to launch as scheduled. Bill Gerstenmaier stated that the preparations and processing of the vehicle went extremely well and they are looking forward to increasing the crew size to three. Then the floor was open to questions from the press.

  9. "Universe" event at AIMS

    NASA Astrophysics Data System (ADS)

    2008-06-01

    Report of event of 11 May 2008 held at the African Institute of Mathematical Sciences (Muizenberg, Cape), with speakers Michael Griffin (Administrator of NASA), Stephen Hawking (Cambridge), David Gross (Kavli Institute, Santa Barbara) and George Smoot (Berkeley).

  10. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin reviews his written testimony prior to the start of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  11. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin testifies makes a point during testimony in front of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  12. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    NASA Administrator Michael Griffin reads from his written testimony while testifying in front of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  13. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, speaks during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  14. ACHP | News

    Science.gov Websites

    that the Department of the Navy and the National Aeronautics and Space Administration (NASA) work recommendations came in letters addressed to Michael D. Griffin, NASA administrator, and Donald C. Winter listed U.S. Naval Air Station Sunnyvale, California, Historic District. While the Navy and NASA will make

  15. Fiscal Year 2007 House Budget Hearing

    NASA Image and Video Library

    2006-02-16

    U.S. Rep. Vernon J. Ehlers , R-Mich., left, talks with NASA Administrator Michael Griffin, right, as NASA Deputy Administrator Shana Dale looks on prior to the start of a hearing before the House Science & Technology Committee regarding NASA's FY 2007 budget request, Thursday, Feb., 16, 2006, in Washington. Photo Credit: (NASA/Bill Ingalls)

  16. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    Dean Acosta, NASA Deputy Assistant Administrator and Press Secretary, moderates a press conference with NASA Administrator Michael Griffin Scott Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  17. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, left, Scott Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right, are seen during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  18. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    Members of the media listen during a press conference with NASA Administrator Michael Griffin, Scott Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, outlining specific center responsibilities associated with the Constellation Program for robotic and human Moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  19. β-DECAY Studies at Triumf and Future Opportunities with Griffin

    NASA Astrophysics Data System (ADS)

    Garnsworthy, A. B.; Ball, G. C.; Bender, P. C.; Churchman, R.; Close, A.; Glister, J.; Hackman, G.; Ketelhut, S.; Krücken, R.; Sjue, S. K. L.; Tardiff, E.; Garrett, P. E.; Demand, G. A.; Dunlop, R.; Finlay, P.; Hadinia, B.; Leach, K.; Michetti-Wilson, J.; Rand, E. T.; Svensson, C. E.; Andreoiu, C.; Ashley, R.; Chester, A.; Cross, D.; Starosta, K.; Wang, Z.; Zganjar, E. F.

    2013-03-01

    The 8π spectrometer at TRIUMF-ISAC-I and a powerful suite of ancillary detectors support a wide program of research in the fields of nuclear structure, nuclear astrophysics and fundamental symmetries with low-energy radioactive beams.Work is underway to upgrade the Ge detectors and DAQ aspects of the facility to a new state-of-the-art γ-ray spectrometer, GRIFFIN, which will become operational in 2014. GRIFFIN will constitute an increase in the γ-γ efficiency of close to a factor of 300 over the current setup and extend the capabilities for investigations of exotic nuclei produced at ISAC.

  20. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin addresses NASA employees and members of the media about the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration during a NASA Update on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  1. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, left, Scott J. Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right, announce to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Photo Credit: (NASA/Bill Ingalls)

  2. STS-121 Space Shuttle Processing Update

    NASA Image and Video Library

    2006-04-27

    NASA Administrator Michael Griffin, left, and Associate Administrator for Space Operations William Gerstenmaier, right, look on as Space Shuttle Program Manager Wayne Hale talks from NASA's Marshall Space Flight Center about the space shuttle's ice frost ramps during a media briefing about the space shuttle program and processing for the STS-121 mission, Friday, April 28, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  3. Organocatalytic aza-Michael/retro-aza-Michael reaction: pronounced chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction.

    PubMed

    Cai, Yong-Feng; Li, Li; Luo, Meng-Xian; Yang, Ke-Fang; Lai, Guo-Qiao; Jiang, Jian-Xiong; Xu, Li-Wen

    2011-05-01

    A detailed experimental investigation of an aza-Michael reaction of aniline and chalcone is presented. A series of Cinchona alkaloid-derived organocatalysts with different functional groups were prepared and used in the aza-Michael and retro-aza-Michael reaction. There was an interesting finding that a complete reversal of stereoselectivity when a benzoyl group was introduced to the cinchonine and cinchonidine. The chirality amplification vs. time proceeds in the quinine-derived organocatalyst containing silicon-based bulky group, QN-TBS, -catalyzed aza-Michael reaction under solvent-free conditions. In addition, we have demonstrated for the first time that racemization was occurred in suitable solvents under mild conditions due to retro-aza-Michael reaction of the Michael adduct of aniline with chalcone. These indicate the equilibrium of retro-aza-Michael reaction and aza-Michael reaction produce the happening of chirality amplification in aza-Michael reaction and racemization via retro-aza-Michael reaction under different conditions, which would be beneficial to the development of novel chiral catalysts for the aza-Michael reactions. Copyright © 2011 Wiley-Liss, Inc.

  4. GRIFFIN: A versatile methodology for optimization of protein-lipid interfaces for membrane protein simulations

    PubMed Central

    Staritzbichler, René; Anselmi, Claudio; Forrest, Lucy R.; Faraldo-Gómez, José D.

    2014-01-01

    As new atomic structures of membrane proteins are resolved, they reveal increasingly complex transmembrane topologies, and highly irregular surfaces with crevices and pores. In many cases, specific interactions formed with the lipid membrane are functionally crucial, as is the overall lipid composition. Compounded with increasing protein size, these characteristics pose a challenge for the construction of simulation models of membrane proteins in lipid environments; clearly, that these models are sufficiently realistic bears upon the reliability of simulation-based studies of these systems. Here, we introduce GRIFFIN, which uses a versatile framework to automate and improve a widely-used membrane-embedding protocol. Initially, GRIFFIN carves out lipid and water molecules from a volume equivalent to that of the protein, so as to conserve the system density. In the subsequent optimization phase GRIFFIN adds an implicit grid-based protein force-field to a molecular dynamics simulation of the pre-carved membrane. In this force-field, atoms inside the implicit protein volume experience an outward force that will expel them from that volume, whereas those outside are subject to electrostatic and van-der-Waals interactions with the implicit protein. At each step of the simulation, these forces are updated by GRIFFIN and combined with the intermolecular forces of the explicit lipid-water system. This procedure enables the construction of realistic and reproducible starting configurations of the protein-membrane interface within a reasonable timeframe and with minimal intervention. GRIFFIN is a standalone tool designed to work alongside any existing molecular dynamics package, such as NAMD or GROMACS. PMID:24707227

  5. Space Shuttle Discovery Launch

    NASA Image and Video Library

    2008-05-31

    NASA Administrator, Michael Griffin watches the launch of the Space Shuttle Discovery (STS-124) from the Launch Control Center Saturday, May 31, 2008, at the Kennedy Space Center in Cape Canaveral, Fla. The Shuttle lifted off from launch pad 39A at 5:02 p.m. EDT. Photo Credit: (NASA/Bill Ingalls)

  6. STS118-S-073

    NASA Image and Video Library

    2007-08-21

    STS118-S-073 (21 Aug. 2007) --- NASA Administrator Michael Griffin (center in white shirt) and other NASA managers give thumbs up signals to the crew of the Space Shuttle Endeavour shortly after its touchdown August 21, 2007, at the Kennedy Space Center, Florida, concluding STS-118. Photo Credit: NASA/Bill Ingalls

  7. Constellation Program Press Conference

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, seated left, Scott Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right, are seen during a press conference outlining specific center responsibilities associated with the Constellation Program for robotic and human moon and Mars exploration, Monday, June 5, 2006, at NASA Headquarters in Washington. Dean Acosta, NASA Deputy Assistant Administrator and Press Secretary, far left, moderates the program. Photo Credit (NASA/Bill Ingalls)

  8. 5. ROOFTOPS, ISHERWOOD HALL (BUILDING NO. 104), GRIFFIN (BUILDING NO. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ROOFTOPS, ISHERWOOD HALL (BUILDING NO. 104), GRIFFIN (BUILDING NO. 110), MELVILLE HALL (BUILDING NO. 116) LOOKING WEST FROM CLOCK TOWER OF MAHAN HALL - U.S. Naval Academy, Annapolis, Anne Arundel County, MD

  9. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    Jeff Hanley, Constellation Program Manager, right, announces to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Hanley is joined by Scott J. Horowitz, NASA Associate Administrator for Exploration Systems and NASA Administrator Michael Griffin, left. Photo Credit: (NASA/Bill Ingalls)

  10. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    NASA Administrator Michael Griffin, left, announces to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. He is joined by Scott J. Horowitz, NASA Associate Administrator for Exploration Systems and Jeff Hanley, Constellation Program Manager, right. Photo Credit: (NASA/Bill Ingalls)

  11. Constellation Program Update

    NASA Image and Video Library

    2006-06-04

    Scott J. Horowitz, NASA Associate Administrator for Exploration Systems, center, announces to NASA employees and members of the media the responsibilities of the NASA centers associated with the Constellation Program for robotic and human Moon and Mars exploration on Wednesday, June 5, 2006, at NASA Headquarters in Washington. Horowitz was joined by NASA Administrator Michael Griffin, left, and Jeff Hanley, Constellation Program Manager. Photo Credit: (NASA/Bill Ingalls)

  12. STS-121 Space Shuttle Processing Update

    NASA Image and Video Library

    2006-04-27

    NASA Administrator Michael Griffin, left, and Associate Administrator for Space Operations William Gerstenmaier, right, look on as Space Shuttle Program Manager Wayne Hale from NASA's Marshall Space Flight Center, holds a test configuration of an ice frost ramp during a media briefing about the space shuttle program and processing for the STS-121 mission, Friday, April 28, 2006, at NASA Headquarters in Washington. Photo Credit (NASA/Bill Ingalls)

  13. Smoot Cosmology Group

    Science.gov Websites

    annually at Nasa Ames Research Center, in the heart of Silicon Valley, for 10 weeks of discussions on how _____________________________________________________________________________________ Hawking, NASA Head, Nobel Winners Visit The African Institute for Mathematical Sciences (AIMS) AIMS Stephen Hawking, the NASA Administrator Michael Griffin, and the winners of the 2004 and 2006 Nobel Prizes

  14. House Hearing Nunn-McCurdy Review of NPOESS

    NASA Image and Video Library

    2006-06-08

    NASA Administrator Michael Griffin, testifies before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

  15. STS-114: Discovery Launch Readiness Press Conference

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Michael Griffin, NASA Administrator; Wayne Hale, Space Shuttle Deputy Program Manager; Mike Wetmore, Director of Shuttle Processing; and 1st Lieutenant Mindy Chavez, Launch Weather Officer-United States Air Force 45th Weather Squadron are in attendance for this STS-114 Discovery launch readiness press conference. The discussion begins with Wayne Hale bringing to the table a low level sensor device for everyone to view. He talks in detail about all of the extensive tests that were performed on these sensors and the completion of these ambient tests. Chavez presents her weather forecast for the launch day of July 26th 2005. Michael Griffin and Wayne Hale answer questions from the news media pertaining to the sensors and launch readiness. The video ends with footage of Pilot Jim Kelly and Commander Eileen Collins conducting test flights in a Shuttle Training Aircraft (STA) that simulates Space Shuttle landing.

  16. Contaminants in American alligator eggs from Lake Apopka, Lake Griffin, and Lake Okeechobee, Florida

    USGS Publications Warehouse

    Heinz, Gary H.; Percival, H. Franklin; Jennings, Michael L.

    1991-01-01

    Residues of organochlorine pesticides, polychlorinated biphenyls (PCBs), and 16 elements were measured in American alligator (Alligator mississippiensis) eggs collected in 1984 from Lakes Apopka, Griffin, and Okeechobee in central and south Florida. Organochlorine pesticides were highest in eggs from Lake Apopka. None of the elements appeared to be present at harmful concentrations in eggs from any of the lakes. A larger sample of eggs was collected in 1985, but only from Lakes Griffin, a lake where eggs were relatively clean, and Apopka, where eggs were most contaminated. In 1985, hatching success of artificially incubated eggs was lower for Lake Apopka, and several organochlorine pesticides were higher than in eggs from Lake Griffin. However, within Lake Apopka, higher levels of pesticides in chemically analyzed eggs were not associated with reduced hatching success of the remaining eggs in the clutch. Therefore, it did not appear that any of the pesticides we measured were responsible for the reduced hatching success of Lake Apopka eggs.

  17. Fiscal Year 2007 Budget Press Conference

    NASA Image and Video Library

    2006-02-06

    NASA Administrator Michael Griffin, seated center, outlines the President's budget for fiscal year 2007 during a news conference, Monday, Feb. 6, 2006, at NASA Headquarters in Washington. The administrator was joined by the heads of NASA's four mission directorates to explain how the proposed $16.8 billion dollar budget supports the Vision for Space Exploration. The budget represents a 3.2% increase above the Fiscal Year 2006 appropriated budget. Photo Credit: (NASA/Bill Ingalls)

  18. Fiscal Year 2007 Budget Press Conference

    NASA Image and Video Library

    2006-02-06

    NASA Associate Administrator for Aeronautics Research Lisa J. Porter answers reporters questions during the fiscal year 2007 news conference, Monday, Feb. 6, 2006, at NASA Headquarters in Washington. NASA Administrator Michael Griffin was joined by the heads of NASA's four mission directorates to explain how the proposed $16.8 billion dollar budget supports the Vision for Space Exploration. The budget represents a 3.2% increase above the fiscal year 2006 appropriated budget. Photo Credit: (NASA/Bill Ingalls)

  19. Some recollections of D. R. Griffin as a young man

    NASA Astrophysics Data System (ADS)

    Galambos, Robert

    2004-05-01

    In 1939 Don Griffin invited me to join him in his earliest bat echolocation experiments. I will tell a few stories about what we two graduate students did together, and show the sound movie in which, for the first time, we recorded their cries as they flew and avoided obstacles.

  20. Leadership in Space: Selected Speeches of NASA Administrator Michael Griffin, May 2005 - October 2008

    NASA Technical Reports Server (NTRS)

    Griffin, Michael

    2008-01-01

    Speech topics include: Leadership in Space; Space Exploration: Real and Acceptable Reasons; Why Explore Space?; Space Exploration: Filling up the Canvas; Continuing the Voyage: The Spirit of Endeavour; Incorporating Space into Our Economic Sphere of Influence; The Role of Space Exploration in the Global Economy; Partnership in Space Activities; International Space Cooperation; National Strategy and the Civil Space Program; What the Hubble Space Telescope Teaches Us about Ourselves; The Rocket Team; NASA's Direction; Science and NASA; Science Priorities and Program Management; NASA and the Commercial Space Industry; NASA and the Business of Space; American Competitiveness: NASA's Role & Everyone's Responsibility; Space Exploration: A Frontier for American Collaboration; The Next Generation of Engineers; System Engineering and the "Two Cultures" of Engineering; Generalship of Engineering; NASA and Engineering Integrity; The Constellation Architecture; Then and Now: Fifty Years in Space; The Reality of Tomorrow; and Human Space Exploration: The Next 50 Years.

  1. Michael Ulsh | NREL

    Science.gov Websites

    Michael Ulsh Photo of Michael Ulsh Michael Ulsh Manufacturing R&D Project Lead Michael.Ulsh -line quality control, the study of the performance and durability effects of manufacturing defects, and lead for a multi-lab consortium on solution processing and roll-to-roll manufacturing, and is involved

  2. House Hearing Nunn-McCurdy Review of NPOESS

    NASA Image and Video Library

    2006-06-07

    NOAA Administrator, Vice Admiral Conrad C. Lautenbacher, Jr., U.S. Navy (Ret.), left, NASA Administrator Michael Griffin and Under Secretary of the Air Force Dr. Ronald Sega, right, testify before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

  3. House Hearing Nunn-McCurdy Review of NPOESS

    NASA Image and Video Library

    2006-06-08

    NOAA Administrator, Vice Admiral Conrad C. Lautenbacher, Jr., U.S. Navy (Ret.), left, NASA Administrator Michael Griffin and Under Secretary of the Air Force Dr. Ronald Sega, right, testify before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

  4. House Hearing Nunn-McCurdy Review of NPOESS

    NASA Image and Video Library

    2006-06-07

    NASA Administrator Michael Griffin, left, testifies before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, as Under Secretary of the Air Force Dr. Ronald Sega looks on, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

  5. KSC-08pd0112

    NASA Image and Video Library

    2008-02-01

    KENNEDY SPACE CENTER, FLA. -- (From left) NASA Associate Administrator for Space Operations William Gerstenmaier; Evelyn Husband-Thompson, widow of Colonel Rick Husband, who died in the space shuttle Columbia accident; and NASA Administrator Michael Griffin pause in front of the flowers left in remembrance of the fallen heroes. Kennedy marked the NASA Day of Remembrance with special ceremonies. This year the crew of Columbia was remembered in a special way on the day that marked the fifth anniversary of the Columbia accident. Photo credit: NASA/Kim Shiflett

  6. 76 FR 21406 - Michael J. Aruta, M.D.; Decision and Order

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... DEPARTMENT OF JUSTICE Drug Enforcement Administration [Docket No. 10-40] Michael J. Aruta, M.D.; Decision and Order ACTION: Correction. On Thursday, April 7, 2011, the Drug Enforcement Administration published the above-titled Decision and Order, as well as the Decision of the Administrative Law Judge (76...

  7. USDA Memorandum of Understanding Signing

    NASA Image and Video Library

    2008-07-22

    U.S. Senator Kay Bailey Hutchison, R-Texas looks on as Secretary of Agriculture Ed Schafer, left, shakes hands with NASA Administrator Michael Griffin after signing a memorandum of understanding (MOU) between NASA and USDA Wednesday, July 23, 2008, at the Russell Senate Office Building in Washington. The MOU will enable the USDA's Agricultural Research Service (ARS) to conduct plant and animal related research on the International Space Station (ISS). Photo Credit: (NASA/Bill Ingalls)

  8. House Hearing Nunn-McCurdy Review of NPOESS

    NASA Image and Video Library

    2006-06-08

    Under Secretary of the Air Force Dr. Ronald Sega, right, testifies before the House Committee on Science and Technology regarding the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program as NASA Administrator Michael Griffin, left, looks at a television monitor, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

  9. House Hearing Nunn-McCurdy Review of NPOESS

    NASA Image and Video Library

    2006-06-07

    Chairman of the House Committee on Science and Technology U.S. Rep. Sherwood Boehlert, R-N.Y., left, shakes hands with NASA Administrator Michael Griffin prior to a hearing on the future of the National Polar-orbiting Operational Environmental Satellite System (NPOESS) and results of the Nunn-McCurdy review of NOAA’s weather satellite program, Thursday, June 8, 2006, at the Rayburn House Office Building in Washington. Photo Credit: (NASA/Bill Ingalls)

  10. KSC-08pd1806

    NASA Image and Video Library

    2008-06-23

    CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (third from right on the dais) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At the table representing NASA are Deputy Associate Administrator of Exploration Systems Doug Cooke, Administrator Michael Griffin and Associate Administrator of Space Operations William Gerstenmaier. Photo credit: NASA/Kim Shiflett

  11. NASA Shared Services Center breaks ground

    NASA Image and Video Library

    2006-02-24

    NASA officials and elected leaders were on hand for the groundbreaking ceremony of the NASA Shared Services Center Feb. 24, 2006, on the grounds of Stennis Space Center. The NSSC provides agency centralized administrative processing, human resources, procurement and financial services. From left, Louisiana Economic Development Secretary Mike Olivier, Stennis Space Center Director Rick Gilbrech, Computer Sciences Corp. President Michael Laphen, NASA Deputy Administrator Shana Dale, Rep. Gene Taylor, Sen. Trent Lott, Mississippi Gov. Haley Barbour, NASA Administrator Mike Griffin and Shared Services Center Executive Director Arbuthnot use golden shovels to break ground at the site.

  12. KSC-08pd1805

    NASA Image and Video Library

    2008-06-23

    CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (right) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. On the left is Florida Sen. Mel Martinez. NASA was represented by Deputy Associate Administrator of Exploration Systems Doug Cooke, Administrator Michael Griffin and Associate Administrator of Space Operations William Gerstenmaier. Photo credit: NASA/Kim Shiflett

  13. KSC-08pd1807

    NASA Image and Video Library

    2008-06-23

    CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (third from right on the dais) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At the table representing NASA are Deputy Associate Administrator of Exploration Systems Doug Cooke, Administrator Michael Griffin and Associate Administrator of Space Operations William Gerstenmaier. Photo credit: NASA/Kim Shiflett

  14. NASA Shared Services Center breaks ground

    NASA Technical Reports Server (NTRS)

    2006-01-01

    NASA officials and elected leaders were on hand for the groundbreaking ceremony of the NASA Shared Services Center Feb. 24, 2006, on the grounds of Stennis Space Center. The NSSC provides agency centralized administrative processing, human resources, procurement and financial services. From left, Louisiana Economic Development Secretary Mike Olivier, Stennis Space Center Director Rick Gilbrech, Computer Sciences Corp. President Michael Laphen, NASA Deputy Administrator Shana Dale, Rep. Gene Taylor, Sen. Trent Lott, Mississippi Gov. Haley Barbour, NASA Administrator Mike Griffin and Shared Services Center Executive Director Arbuthnot use golden shovels to break ground at the site.

  15. KSC-08pd1808

    NASA Image and Video Library

    2008-06-23

    CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (third from right on the dais) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At the table representing NASA are Administrator Michael Griffin and Associate Administrator of Space Operations William Gerstenmaier. Photo credit: NASA/Kim Shiflett

  16. KSC-08pd1809

    NASA Image and Video Library

    2008-06-23

    CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (third from right on the dais) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At the table representing NASA are Administrator Michael Griffin and Associate Administrator of Space Operations William Gerstenmaier. Photo credit: NASA/Kim Shiflett

  17. STS-120 landing

    NASA Image and Video Library

    2007-11-07

    (left to right) NASA Administrator Michael Griffin, NASA Assistant Administrator for Public Affairs David Mould and NASA Space Shuttle Manager Wayne Hale watch as the space shuttle Discovery comes in for landing at NASA's Kennedy Space Center, Fla., completing the 15-day STS-120 mission to the International Space Station. Discovery landed at 1:01pm EST Wednesday after a mission that included on-orbit construction of the station with the installation of the Harmony Node 2 module and the relocation of the P6 truss. Photo Credit: 'NASA/Bill Ingalls"

  18. 07pd3206

    NASA Image and Video Library

    2007-11-07

    (left to right) NASA Administrator Michael Griffin, NASA Assistant Administrator for Public Affairs David Mould and NASA Space Shuttle Manager Wayne Hale watch as the space shuttle Discovery comes in for landing at NASA's Kennedy Space Center, Fla., completing the 15-day STS-120 mission to the International Space Station. Discovery landed at 1:01pm EST Wednesday after a mission that included on-orbit construction of the station with the installation of the Harmony Node 2 module and the relocation of the P6 truss. Photo Credit: 'NASA/Bill Ingalls"

  19. KSC-07pd3206

    NASA Image and Video Library

    2007-11-07

    KENNEDY SPACE CENTER, FLA. -- (From left) NASA Administrator Michael Griffin, NASA Assistant Administrator for Public Affairs David Mould and NASA Space Shuttle Manager Wayne Hale watch as the space shuttle Discovery comes in for landing at NASA's Kennedy Space Center, Fla., completing the 15-day, STS-120 mission to the International Space Station. Discovery landed at 1:01 p.m. EST Wednesday after a mission that included on-orbit construction of the station with the installation of the Harmony Node 2 module and the relocation of the P6 truss. Photo credit: NASA/Bill Ingalls

  20. Biography for Michael Rossol | NREL

    Science.gov Websites

    Biography for Michael Rossol Michael Rossol Michael Rossol Resource Data Scientist Michael.Rossol @nrel.gov | 303-275-3680 Michael Rossol is a member of the Systems Modeling team within the Systems Modeling

  1. STS-119 Breakfast Meeting with NASA Administrator Mike Griffin

    NASA Image and Video Library

    2009-01-09

    NASA Administrator Mike Griffen having breakfast with the STS-119 crew, then receiving a tour of the Small Pressurized Rover demonstration. Photo Date: January 9, 2009 Location: Bldg. 27 - Astronaut Quarantine. Photographer: R.Markowitz, x37739

  2. Re-Establishing Social Studies as a Core Subject: An Interview with Susan Griffin

    ERIC Educational Resources Information Center

    Griffin, Susan

    2014-01-01

    NCSS Executive Director Susan Griffin was chair of the Task Force of Professional Organizations that worked with the Social Studies Assessment, Curriculum, and Instruction Collaborative (SSACI) of the Council of Chief State School Officers to initiate and guide the development of the "College, Career and Civic Life (C3) Framework for Social…

  3. KSC-08pd1804

    NASA Image and Video Library

    2008-06-23

    CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (third from right on the dais) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At Nelson's right is Florida Sen. Mel Martinez. Seated at left are NASA representatives Deputy Associate Administrator of Exploration Systems Doug Cooke, Administrator Michael Griffin and Associate Administrator of Space Operations William Gerstenmaier. Photo credit: NASA/Kim Shiflett

  4. STS-121: Discovery Post Launch Press Briefing

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The briefing begins with Dean Acousta (NASA Press Secretary) introducing Michael Griffin (NASA Administrator), Bill Gerstenmaier (Associate Administrator for Space Operations) Wayne Hale (Space Shuttle Program Manager), John Shannon (Chairman, Mission Management Team, JSC), and Mike Leinbach (NASA Launch Director). The teams effort and dedication paid off in the form of a perfect launch and the weather cooperated. The Mission Management Team no problems during inspection. Debris assessment at 2 min. 47 sec. and 4 min. 50 sec. will be discussed when that information becomes available.The floor was then open for questions from the press.

  5. Maniac Talk - Michael Mishchenko

    NASA Image and Video Library

    2015-01-26

    Michael Mishchenko Maniac Lecture, January 26, 2015 NASA climate scientist Dr. Michael I. Mishchenko presented a Maniac Talk entitled "How much first-principle physics do we need in remote-sensing and atmospheric-radiation research." Michael explained his skepticism and how it has shaped his contributions to the disciplines of electromagnetic scattering, radiative transfer, and remote sensing, which have found widespread use.

  6. Systems 2020

    DTIC Science & Technology

    2012-03-22

    USC Team Members: SERC Research Council Dr. Abhi Deshmukh , Purdue Dr. Michael Griffin. U. Alabama-Huntsville Dr. Barry Horowitz, U. Virginia Dr...Areas ................................................. 34 3.2.1 Affordability, Agility, and Resilience (Barry Boehm and Abhi Deshmukh , Leads...statement was reinterpreted to involve the SERC Research Council (Drs. Deshmukh , Griffin, Horowitz, Rouse, and Wade, with Dr. Boehm as chair) in defining

  7. 75 FR 11899 - Certificate of Alternative Compliance for the Offshore Supply Vessel JOE GRIFFIN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... ``Search.'' FOR FURTHER INFORMATION CONTACT: If you have questions on this notice, call CWO2 David Mauldin, District Eight, Prevention Branch, U.S. Coast Guard, telephone 504-671-2153. If you have questions on... for the offshore supply vessel JOE GRIFFIN. Full compliance with 72 COLREGS and the Inland Rules Act...

  8. Obituary: Michael John Klein, 1940-2005

    NASA Astrophysics Data System (ADS)

    Gulkis, Samuel

    2006-12-01

    Michael John Klein died on 14 May 2005 at home in South Pasadena, California. The cause of death was tongue cancer that metastasized to the lungs. He was a non-smoker. Mike was a passionate radio astronomer, a trusted astronomical observer, an educator and a family man. Mike was born on 19 January 1940 in Ames, Iowa, the son of Florence Marie (Graf) and Fred Michael Klein. His mother was a homemaker, and his father was a banker. Mike had two older sisters, Lois Jean (Klein) Flauher and Marilyn June (Klein) Griffin. In 1962, Mike married his high school sweetheart Barbara Dahlberg, who survives him along with their three children, Kristin Marie (Klein) Shields, Michael John Klein Jr., Timothy Joel Klein, and six grandchildren. Mike developed a love for astronomy early in his life, and credited an early morning, newspaper-delivery route that he had at age twelve, which took him outside well before sunrise. He told family members that as he walked along his route, he stared into the sky and wondered what everything was. He studied sky charts, located stars, and began to understand how the planets shifted their positions relative to the stars each day. Another big influence in Mike's life was his brother in-law, Jim Griffin. Jim helped Mike understand that his passion for science did not have to remain a hobby, but could and should become a career. Jim's encouragement led Mike to attend Iowa State University in Ames, where he earned a BS in electrical engineering in 1962. Mike then started graduate school in electrical engineering at Michigan State, but after one semester transferred to the University of Michigan, Ann Arbor, where he earned an MS (1966) and PhD (1968) in astronomy. His doctoral dissertation, under the direction of Professor Fred Haddock, was based on extensive observations of the planets and examined the physical and thermal properties of planetary atmospheres and surfaces. Mike was awarded a Resident Research Associate position at JPL by the National

  9. KSC-08pd1810

    NASA Image and Video Library

    2008-06-23

    CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson (right) focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At the dais with Nelson are NASA Administrator Michael Griffin (left) and Florida Sen. Mel Martinez (center). Photo credit: NASA/Kim Shiflett

  10. STS-121: Discovery Post Flight Readiness Review Briefing

    NASA Technical Reports Server (NTRS)

    2006-01-01

    This post Flight Readiness Review (FRR) briefing begins with NASA Press Secretary Dean Acosta, introducing the panel who consist of: NASA Administrator, Dr. Michael Griffin; Associate Administrator for Space Operations, Bill Gerstenmaier; Space Shuttle Program Manager, Wayne Hale; and NASA Launch director, Mike Leinbach. The discussion begins with Dr. Michael Griffin, who expresses his gladness to be a part of the FRR. Bill Gerstenmaier talks about how they were very thorough about the subjects reviewed and that they wanted to make sure that they were ready to fly. He discusses and presents two slides. The first slide is a description of the LO2 intertank and LH2 ice/frost ramps staging location and the second are the top ten LH2 Ice/Frost Ramp Foam Loss events. Wayne Hale gives his thoughts on the human element that came into play during the FRRs. He talks about the willingness of everyone to speak their mind, instead of giving short comments. He expressed that this element is a huge step forward for NASA. Mike Leinbach reports on the processing of the vehicle and expresses that everything is going well and there is nothing to prohibit the launch. He also gives a good report on Atlantis, in case there is a need to use the vehicle. This FRR briefing ends with a short question and answer period from the press on topics such as debris, foam loss, ice/frost ramp redesign, crew risks, and launch date.

  11. KSC-06pd1578

    NASA Image and Video Library

    2006-07-17

    KENNEDY SPACE CENTER, FLA. - During the traditional post-flight walk-around after the landing of an orbiter, crew members Michael Fossum, mission specialist, and Steven Lindsey, commander, talk with NASA Administrator Mike Griffin (left). At right is Associate Administrator Rex Geveden. Discovery's smooth and perfect landing was on time at 9:14 a.m. EDT on Runway 15 of NASA's Shuttle Landing Facility after traveling 5.3 million miles on 202 orbits. Mission elapsed time was 12 days, 18 hours, 37 minutes and 54 seconds. The landing is the 62nd at Kennedy Space Center and the 32nd for Discovery. Photo credit: NASA/Kim Shiflett

  12. STS-114 Homecoming Ceremony

    NASA Image and Video Library

    2005-08-10

    JSC2005-E-33356 (10 August 2005) --- U.S. Senator Kay Bailey Hutchison (R.-Texas) speaks to a crowd on hand at Ellington Field’s Hangar 276 near Johnson Space Center (JSC) during the STS-114 crew return ceremonies. Seated (from the left) are NASA Administrator Michael Griffin; astronauts Eileen M. Collins, commander; James M. Kelly, pilot; Soichi Noguchi, mission specialist representing Japan Aerospace Exploration Agency (JAXA); Stephen K. Robinson, mission specialist. Not pictured are astronauts Andrew S. W. Thomas, Wendy B. Lawrence and Charles J. Camarda, mission specialists.

  13. Michael E. Himmel | NREL

    Science.gov Websites

    E. Himmel Photo of Michael E. Himmel Michael Himmel Senior Research Fellow I-Molecular Biology ;Towards a molecular-level theory of carbohydrate processivity," Curr. Opinion Biotechnol. (2014 University, Department of Biochem. & Molecular Biol., Distinguished Alumnus (2014) Battelle Memorial

  14. Supreme Court Hears Privacy Case Between NASA and Jet Propulsion Laboratory Scientists

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2010-10-01

    After NASA put into practice the 2004 Homeland Security Presidential Directive-12, known as HSPD-12, Dennis Byrnes talked to then-NASA administrator Michael Griffin. Byrnes recalls that Griffin told him in 2007 that if he didn’t like the agency's implementation of HSPD-12, he should go to court. That's exactly what Byrnes, an employee of the California Institute of Technology (Caltech) working as a senior engineer at NASA's Jet Propulsion Laboratory (JPL) in Pasadena, Calif., did. Concerned about prying and open-ended background investigations of federal contractors through NASA's implementation of HSPD-12, he, along with lead plaintiff Robert Nelson and 26 other Caltech employees working at JPL, sued NASA. Following several lower court decisions, including an injunction issued by a U.S. federal appeals court in response to a plaintiff motion, the case made it all the way to the U.S. Supreme Court, which heard oral arguments on 5 October.

  15. Career Profile: Flight Operations Engineer (Aeronautics) Brian Griffin

    NASA Image and Video Library

    2014-10-17

    Operations engineers at NASA's Armstrong Flight Research Center help to advance science, technology, aeronautics, and space exploration by managing operational aspects of a flight research project. They serve as the governing authority on airworthiness related to the modification, operation, or maintenance of specialized research or support aircraft so those aircraft can be flown safely without jeopardizing the pilots, persons on the ground or the flight test project. With extensive aircraft modifications often required to support new research and technology development efforts, operations engineers are key leaders from technical concept to flight to ensure flight safety and mission success. Other responsibilities of an operations engineer include configuration management, performing systems design and integration, system safety analysis, coordinating flight readiness activities, and providing real-time flight support. This video highlights the responsibilities and daily activities of NASA Armstrong operations engineer Brian Griffin during the preparation and execution of flight tests in support of aeronautics research. http://www.nasa.gov/centers/armstrong/home/ http://www.nasa.gov/

  16. Draft genome sequence of Xylella fastidiosa supsp. multiplex strain Griffin-1 from Quercus rubra in Georgia

    USDA-ARS?s Scientific Manuscript database

    The draft genome sequence of Xylella fastidiosa subsp. multiplex Strain Griffin-1 isolated from a red oak tree (Quercus rubra) in Georgia, U.S.A. is reported. The bacterium has a genome size of 2,387,314 bp with 51.7% G+C content and comprises 2,903 predicted open reading frames (ORFs), and 50 RNA g...

  17. Caucasus conflict challenges US space policy

    NASA Astrophysics Data System (ADS)

    Gwynne, Peter

    2008-10-01

    A leaked e-mail sent to staff by NASA administrator Michael Griffin has indicated that there could be a "lengthy" period with no US crew based on the International Space Station (ISS). His fears stem from a surprising source: the recent conflict between Georgia and Russia, and the subsequent occupation by Russian troops of South Ossetia - a disputed part of Georgia - and Georgia itself. It triggered a frosty relationship between the US and Russian governments, which has now cast doubts on an agreement to permit Americans to fly onboard the Russian Soyuz craft to reach the orbiting station.

  18. Jack Michael's Motivation

    ERIC Educational Resources Information Center

    Miguel, Caio F.

    2013-01-01

    Among many of Jack Michael's contributions to the field of behavior analysis is his behavioral account of motivation. This paper focuses on the concept of "motivating operation" (MO) by outlining its development from Skinner's (1938) notion of "drive." Conceptually, Michael's term helped us change our focus on…

  19. Interview with J. Michael Thompson

    ERIC Educational Resources Information Center

    Randall, Mary Elisabeth

    2004-01-01

    J. Michael Thompson is the Vice Provost for Enrollment Management and Dean of Admission and Financial Aid at the University of Southern California. J. Michael has worked in higher education for more than 30 years in a variety of roles at small private and mid-sized and large public universities, and now at USC, a large private university. He has…

  20. 78 FR 29200 - In the Matter of Griffin Mining, Inc., Power Sports Factory, Inc., Star Energy Corp., TransNet...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] In the Matter of Griffin Mining, Inc., Power Sports Factory, Inc., Star Energy Corp., TransNet Corp., Valcom, Inc., and Vibe Records, Inc.; Order of... information concerning the securities of Power Sports Factory, Inc. because it has not filed any periodic...

  1. Maniac Talk - Michael Kurylo

    NASA Image and Video Library

    2016-11-16

    Michael Kurylo Maniac Lecture, November 16, 2016 NASA climate scientist Michael Kurylo presented a Maniac lecture entitled, "An Uncharted Journey: How I Became an Atmospheric Scientist Rather than a Cowboy or a Farmer." Mike described the path that took him from post-WW II housing projects to and through a rural Connecticut neighborhood, how he became convinced about the unrealistic nature of some early naive career dreams, and how he eventually arrived at a career in atmospheric science (research and program management, and their interface with international environmental policy).

  2. KSC-06pd0686

    NASA Image and Video Library

    2006-04-18

    CINCINNATI, OHIO - NASA Administrator Michael Griffin presented the NASA Ambassadors of Exploration award to Neil Armstrong (left). At right is former awardee John Glenn. Armstrong received the award that includes a moon rock to recognize the sacrifices and dedication of the astronauts and others who were part of the Mercury, Gemini and Apollo programs. A former naval aviator, NASA test pilot and Apollo 11 commander, Armstrong was the first human to ever land a spacecraft on the moon and the first to step on the lunar surface. Armstrong's award will be displayed at the Cincinnati Museum Center at Union Terminal. Photo credit: NASA/Bill Ingalls

  3. KSC-06pd0687

    NASA Image and Video Library

    2006-04-18

    CINCINNATI, OHIO - Former astronaut Neil Armstrong stands next to the NASA Ambassadors of Exploration award presented to him by NASA Administrator Michael Griffin. Armstrong received the award that includes a moon rock to recognize the sacrifices and dedication of the astronauts and others who were part of the Mercury, Gemini and Apollo programs. A former naval aviator, NASA test pilot and Apollo 11 commander, Armstrong was the first human to ever land a spacecraft on the moon and the first to step on the lunar surface. Armstrong's award will be displayed at the Cincinnati Museum Center at Union Terminal. Photo credit: NASA/Bill Ingalls

  4. Method for promoting Michael addition reactions

    DOEpatents

    Shah, Pankaj V.; Vietti, David E.; Whitman, David William

    2010-09-21

    Homogeneously dispersed solid reaction promoters having an average particle size from 0.01 .mu.m to 500 .mu.m are disclosed for preparing curable mixtures of at least one Michael donor and at least one Michael acceptor. The resulting curable mixtures are useful as coatings, adhesives, sealants and elastomers.

  5. The Prolonged Downfall of the Democratic Republic of Afghanistan

    DTIC Science & Technology

    2014-05-22

    Afghanistan (London, UK: Pluto Press, 2001); Gilles Dorronsoro, Revolution Unending: Afghanistan, 1979 to the Present, trans. John King (New York, NY...2 (May 2007): 235-61. Griffin, Michael. Reaping the Whirlwind: The Taliban Movement in Afghanistan. London, UK: Pluto Press, 2001. Jalali, Ali

  6. David Cozad, Michael Schumacher and/or Brad Peterson (d/b/a Credit Island Recycling), Davenport, Iowa

    EPA Pesticide Factsheets

    The EPA is providing notice of proposed Administrative Penalty Assessment against David Cozad, Michael Schumacher and/or Brad Peterson (d/b/a Credit Island Recycling), for alleged violations of an industrial stormwater permit issued by IDNR for an applianc

  7. Michael J. Fox: Spurring Research on Parkinson's

    MedlinePlus

    ... on. Feature: Parkinson's Disease Michael J. Fox: Spurring Research on Parkinson's Past Issues / Winter 2014 Table of ... founded the Michael J. Fox Foundation for Parkinson's Research in the year 2000. Photo courtesy of Shutterstock " ...

  8. Michael Lawson | NREL

    Science.gov Websites

    NREL's Ocean Energy team, Dr. Michael Lawson focuses on the areas of wave and water current energy goal of developing an open source design and analysis tool for wave energy conversion (WEC) devices

  9. The Landrum-Griffin Act. Twenty Years of Federal Protection of Union Members' Rights. Labor Relations and Public Policy Series, No. 19.

    ERIC Educational Resources Information Center

    Bellace, Janice R.; Berkowitz, Alan D.

    Enacted in 1959, the Landrum-Griffin Act or Labor-Management Reporting and Disclosure Act was intended to attain maximum protection for the rights of individual workers within the union without undermining the union as an institution necessary for the existence of collective bargaining. Title I is the union members' bill of rights; titles II-VI…

  10. Griffin 2.0 - Development and Evaluation of an Occupant Protection Platform with Active-Blast Mitigation and Crew Floor Isolation

    DTIC Science & Technology

    2016-11-15

    and they include 1) threat size, 2) threat burial depth, 3) soil composition, 4) vehicle standoff, 5) hull geometry, and 6) vehicle mass. However...crucial in engaging as much of the mass as possible. Another feature of the Griffin architecture is the continuous monocoque hull design that...underbody threats up to 200% MRAP Objective (Pratt & Miller Engineering, 2015). Next a low-deformation hull needs to be utilized that will

  11. Michael Faraday's Bicentenary.

    ERIC Educational Resources Information Center

    Williams, L. Pearce; And Others

    1991-01-01

    Six articles discuss the work of Michael Faraday, a chemist whose work revolutionized physics and led directly to both classical field and relativity theory. The scientist as a young man, the electromagnetic experiments of Faraday, his search for the gravelectric effect, his work on optical glass, his laboratory notebooks, and his creative use of…

  12. Goodbye Michael Gove

    ERIC Educational Resources Information Center

    Bassey, Michael

    2014-01-01

    Michael Gove was Secretary of State for Education from May 2010 to July 2014 when the Prime Minister sacked him. With strong opinions arising from his own life experiences and outstanding energy for reform, but severely limited understanding of education and a refusal to consult teachers and other professionals, he imposed half-baked ideas on the…

  13. Michael J. Meaney: Award for Distinguished Scientific Contributions

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents Michael J. Meaney as one of the winners of the American Psychological Association's Award for Distinguished Scientific Contributions (2012). Michael J. Meaney has taken the phenomenon of "handling" of newborn rats and opened a new area of investigation that has given new meaning to epigenetics via his work demonstrating transgenerational…

  14. KSC-08pd1811

    NASA Image and Video Library

    2008-06-23

    CAPE CANAVERAL, Fla. – A Senate field hearing held at the Canaveral Port Authority and chaired by Florida Sen. Bill Nelson focuses on workforce related challenges at NASA's Kennedy Space Center and potential solutions to mitigate the transition's effects on the community. The hearing examined issues surrounding the retirement of the space shuttle and the transition to the new Orion/Ares system. At the table are community representatives Lynda Weatherman, president and CEO of the Economic Development Commission of Florida's Space Coast; Lisa Rice, president of the Brevard Workforce Development Board Inc.; Randy Berridge, president of the Florida High Tech Corridor Council; and Steve Kohler, president of Space Florida. NASA Administrator Michael Griffin is seated at right. Photo credit: NASA/Kim Shiflett

  15. The ERIC Guidebook to the Background Papers for "A Call for Change in Teacher Education: The Report of the National Committee on Excellence in Teacher Education."

    ERIC Educational Resources Information Center

    ERIC Clearinghouse on Teacher Education, Washington, DC.

    This guidebook contains abstracts of papers by the following authors: (1) Michael D. Andrew; (2) Herman E. Behling, Jr.; (3) Ken Carlson; (4) Frederic R. Cyphert and John E. Nichelson; (5) Barbara Dubitsky; (6) David H. Florio; (7) Eva C. Galambos; (8) Hendrik D. Gideonse; (9) Gary A. Griffin; (10) Martin Haberman; (11) Gene Hall, Walter Doyle,…

  16. 4. Photocopy of inkandwatercolor drawing (from St. Michael's Church) Rambusch, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Photocopy of ink-and-watercolor drawing (from St. Michael's Church) Rambusch, illustrator ca. 1932-37 INTERIOR, LOOKING NORTHEAST - St. Michael's Catholic Church, 519 East Third Street, Madison, Jefferson County, IN

  17. Doing It All: Michael Sullivan--Weeks Public Library, NH

    ERIC Educational Resources Information Center

    Library Journal, 2005

    2005-01-01

    Michael Sullivan is a juggler--not a metaphorical one, a real one. He's also a library director, storyteller, competitive chess player, poet, speaker, and former children's librarian who continues to work with the kids in his community. This article summarizes the accomplishments and work of Michael Sullivan.

  18. 76 FR 10352 - Keyser, Michael J.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ID-6495-000] Keyser, Michael J.; Notice of Filing Take notice that on February 15, 2011, Michael J. Keyser submitted for filing, an application for authority to hold interlocking positions, pursuant to section 305(b) of the...

  19. Language and Intercultural Education: An Interview with Michael Byram

    ERIC Educational Resources Information Center

    Porto, Melina

    2013-01-01

    This article reports an interview with Michael Byram, Professor Emeritus, University of Durham in the United Kingdom, during his visit to Argentina in September 2011. Michael Byram is one of the main international referents in intercultural education. The interview addresses issues such as language education, intercultural and citizenship…

  20. Acting Administrator Lightfoot Visits Ball Aerospace

    NASA Image and Video Library

    2017-04-06

    Michael Dean, senior project engineer for the Joint Polar Satellite System (JPSS) program at Ball Aerospace, right, speaks with acting NASA Deputy Administrator Lesa Roe, second from left, and acting NASA Administrator Robert Lightfoot, center, about the 20ft. by 24 ft. vertical thermal vacuum chamber, Thursday, April 6, 2017 during a visit to Ball Aerospace in Boulder, Colo. Photo Credit: (NASA/Joel Kowsky)

  1. Michael Faraday vs. the Spiritualists

    NASA Astrophysics Data System (ADS)

    Hirshfeld, Alan

    2006-12-01

    In the 1850s, renowned physicist Michael Faraday launched a public campaign against pseudoscience and spiritualism, which were rampant in England at the time. Faraday objected especially to claims that electrical or magnetic forces were responsible for paranormal phenomena, such as table-spinning and communication with the dead. Using scientific methods, Faraday unmasked the deceptions of spiritualists, clairvoyants and mediums and also laid bare the credulity of a public ill-educated in science. Despite his efforts, Victorian society's fascination with the paranormal swelled. Faraday's debacle anticipates current controversies about public science education and the interface between science and religion. This episode is one of many described in the new biography, The Electric Life of Michael Faraday (Walker & Co.), which chronicles Faraday's discoveries and his unlikely rise from poverty to the pinnacle of the English science establishment.

  2. Q&A: Michael Honey

    ERIC Educational Resources Information Center

    Helicher, Karl

    2007-01-01

    The mid-1960s saw civil rights victories in Congress during Lyndon B. Johnson's presidency. In "Going Down Jericho Road," Michael Honey wrote how Martin Luther King Jr.'s final focus showed that the struggle for black and working class parity continued. The 1968 Memphis sanitation workers strike was a gritty struggle won in the streets by a host…

  3. Michael Young and the Curriculum Field in South Africa

    ERIC Educational Resources Information Center

    Hoadley, Ursula

    2015-01-01

    The paper addresses the question of what we should make of Michael Young's recent work with respect to curriculum theory by considering the particular case of South African curriculum reform. The paper thus traces two trajectories: the evolution of Michael Young's ideas over time and South African curriculum reform in the post-apartheid period.…

  4. In Brief: NASA issues media rules

    NASA Astrophysics Data System (ADS)

    Zielinski, Sarah

    2006-04-01

    NASA issues media rules NASA scientists will be able to speak freely about their work to the media and the public, under a newly revised policy announced 30 March by NASA Administrator Michael Griffin. Earlier in the year, the agency had been widely criticized after allegations were published that scientists had been prevented from speaking about controversial topics, such as climate change (see Eos 97(9) 2006). The policy is intended to establish a `culture of openness,' in which scientists may communicate the results and conclusions of their scientific research to the public without hindrance. However, NASA scientists will be required to distinguish personal views from those of the agency. The revised policy also outlines the responsibilities other public affairs staff, who will be prohibited from altering or editing scientific information.

  5. Michael Tomasello: Award for Distinguished Scientific Contributions.

    PubMed

    2015-11-01

    The APA Awards for Distinguished Scientific Contributions are presented to persons who, in the opinion of the Committee on Scientific Awards, have made distinguished theoretical or empirical contributions to basic research in psychology. One of the 2015 award winners is Michael Tomasello, who received this award for "outstanding empirical and theoretical contributions to understanding what makes the human mind unique. Michael Tomasello's pioneering research on the origins of social cognition has led to revolutionary insights in both developmental psychology and primate cognition." Tomasello's award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).

  6. ASK Talks with Dr. Michael Hecht

    NASA Technical Reports Server (NTRS)

    Hecht, Michael

    2003-01-01

    Michael Hecht has been a member of NASA's Jet Propulsion Laboratory (JPL) staff since 1982. He is currently Project Manager and co-investigator for the Mars Environmental Compatibility Assessment (MECA)

  7. Michael Thackeray on Lithium-air Batteries

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thackeray, Michael

    2009-01-01

    Michael Thackeray, Distinguished Fellow at Argonne National Laboratory, speaks on the new technology Lithium-air batteries, which could potentially increase energy density by 5-10 times over lithium-ion batteries.

  8. Michael Thackeray on Lithium-air Batteries

    ScienceCinema

    Thackeray, Michael

    2018-02-06

    Michael Thackeray, Distinguished Fellow at Argonne National Laboratory, speaks on the new technology Lithium-air batteries, which could potentially increase energy density by 5-10 times over lithium-ion batteries.

  9. Following Michael Faraday's Footprints

    ERIC Educational Resources Information Center

    Galeano, Javier

    2011-01-01

    Last fall I had the good fortune of receiving financial support to shoot a documentary about Michael Faraday. I took the opportunity to learn more about this great experimentalist and to visit the highlights of places in his life. In this paper, I would like to share a list and description of some of the most remarkable places in London suitable…

  10. The Michael Reaction

    NASA Astrophysics Data System (ADS)

    Poon, Thomas; Mundy, Bradford P.; Shattuck, Thomas W.

    2002-02-01

    A brief account of the Michael reaction is provided, illustrating its versatility as a topic in undergraduate chemistry courses. Included is a short biography of the reaction's namesake, examples of its use in organic synthesis, and its unique role in the defense mechanism of the bacterium Micromonospora echinospora. A computational rationale for the selectivity of 1,4 versus 1,2 addition of nucleophiles to a,b-unsaturated carbonyls is discussed and links to animations suitable for an introductory organic chemistry course are provided.

  11. Catalytic asymmetric Michael reactions promoted by a lithium-free lanthanum-BINOL complex

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sasai, Hiroaki; Arai, Takayoshi; Shibasaki, Masakatsu

    1994-02-23

    In this communication, we report about a new lithium-free BINOL-lanthanum complex, which is quite effective in catalytic asymmetric Michael reaction. We have succeeded in developing effective asymmetric base catalysts, in particular, asymmetric ester enolate catalysts for asymmetric Michael reactions. Two asymmetric lanthanum complexes are now available, namely, BINOL-lanthanum-lithium complex, which is quite effective in catalytic asymmetric nitrosaldol reactions, and a new lithium-free BINOL-lanthanum ester enolate complex, that is very effective in catalytic asymmetric Michael reactions. The two complexes complement each other in their ability to catalyze asymmetric nitroaldol and asymmetric Michael reactions. 14 refs., 1 fig., 2 tabs.

  12. KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and a USA technician examine cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and a USA technician examine cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  13. KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician briefs NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, USA Vice President and Space Shuttle Program Manager Howard DeCastro, and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik on the use of cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician briefs NASA Deputy Program Manager of the Space Shuttle Program Michael Wetmore, USA Vice President and Space Shuttle Program Manager Howard DeCastro, and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik on the use of cold plates in Orbiter Processing Facility Bay 2. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  14. Obituary: Michael James Ledlow, 1964-2004

    NASA Astrophysics Data System (ADS)

    Puxley, Philip John; Grashuis, Randon M.

    2004-12-01

    Michael James Ledlow died on 5 June 2004 from a large, unsuspected brain tumor. Since 2000 he had been on the scientific staff of the Gemini Observatory in La Serena, Chile, initially as a Science Fellow and then as a tenure-track astronomer. Michael was born in Bartlesville, Oklahoma on 1 October 1964 to Jerry and Sharon Ledlow. He obtained his Bachelor Degree in astrophysics at the University of Oklahoma in 1987 and attended the University of New Mexico for his graduate work, obtaining his PhD while studying Galaxy Clusters under Frazer Owen in 1994. From 1995-1997 Michael held a postdoctoral position with Jack Burns at New Mexico State University where he used various astronomical facilities including the VLA and Apache Point Observatory to study distant galaxies. From 1998-2000 Michael rejoined the Physics and Astronomy Department at the University of New Mexico where he was a visiting professor until he moved on to Gemini. At the Gemini Observatory, Mike shared in the excitement, hard work and many long days and nights associated with bringing on-line a major new astronomical facility and its instrumentation. Following its commissioning he assisted visiting observers, supported and took data for many more remote users via the queue system, and for each he showed the same care and attention to detail evident in his own research to ensure that all got the best possible data. His research concentrated on the radio and optical properties of galaxy clusters, especially rich Abell clusters such as A2125, on luminous radio galaxies, including the detection of a powerful double radio source in the "wrong sort of galaxy," the spiral system 0313-192, and on EROs (extremely red objects), dusty galaxies barely detectable at optical wavelengths. Michael thoroughly enjoyed living in Chile and enthusiastically immersed himself in the culture of his surroundings. He and his family were actively involved with the International English Spanish Association in La Serena. He had a

  15. NASA Catches Tropical Storm Leslie and Hurricane Michael in the Atlantic

    NASA Image and Video Library

    2017-12-08

    This visible image of Tropical Storm Leslie and Hurricane Michael was taken by the MODIS instrument aboard both NASA's Aqua and Terra satellites on Sept. 9 at 12:50 p.m. EDT. Credit: NASA Goddard/MODIS Rapid Response Team -- Satellite images from two NASA satellites were combined to create a full picture of Tropical Storm Leslie and Hurricane Michael spinning in the Atlantic Ocean. Imagery from NASA's Aqua and Terra satellites showed Leslie now past Bermuda and Michael in the north central Atlantic, and Leslie is much larger than the smaller, more powerful Michael. Images of each storm were taken by the Moderate Resolution Imaging Spectroradiometer, or MODIS instrument that flies onboard both the Aqua and Terra satellites. Both satellites captured images of both storms on Sept. 7 and Sept. 10. The image from Sept. 7 showed a much more compact Michael with a visible eye. By Sept. 10, the eye was no longer visible in Michael and the storm appeared more elongated from south to north. To continue reading go to: 1.usa.gov/NkUPqn NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing compelling scientific knowledge to advance the Agency’s mission. Follow us on Twitter Like us on Facebook Find us on Instagram

  16. Interview with Michael Apple: The Biography of a Public Intellectual

    ERIC Educational Resources Information Center

    Peters, Michael A.

    2015-01-01

    Michael W. Apple is the John Bascom Professor of Curriculum and Instruction and Educational Policy Studies in the Departments of Curriculum and Instruction (CI) and Educational Policy Studies (EPS) at the University of Wisconsin-Madison School of Education where he has taught since 1970. Michael Apple is one of the foremost educational theorists…

  17. Michael Beitz: Objects of Communication

    ERIC Educational Resources Information Center

    Hoefferle, Mary

    2014-01-01

    For this Instructional Resource, the author interviewed contemporary sculptor Michael Beitz, who uses art to explore the role of designed objects in human communication and emotional experience. This column was written in response to calls for using Enduring Understandings/Big Ideas (National Coalition for Core Arts Standards, 2013; Stewart &…

  18. Michael Faraday, media man.

    PubMed

    Fara, Patricia

    2006-03-01

    Michael Faraday was an enthusiastic portrait collector, and he welcomed the invention of photography not only as a possible means of recording observations accurately, but also as a method for advertising science and its practitioners. This article (which is part of the Science in the Industrial Revolution series) shows that like many eminent scientists, Faraday took advantage of the burgeoning Victorian media industry by posing in various roles.

  19. Synthesis of Triazole Derivatives of Levoglucosenone As Promising Anticancer Agents: Effective Exploration of the Chemical Space through retro-aza-Michael//aza-Michael Isomerizations.

    PubMed

    Tsai, Yi-Hsuan; Borini Etichetti, Carla M; Di Benedetto, Carolina; Girardini, Javier E; Martins, Felipe Terra; Spanevello, Rolando A; Suárez, Alejandra G; Sarotti, Ariel M

    2018-04-06

    The design and synthesis of biomass-derived triazoles and the in vitro evaluation as potential anticancer agents are described. The discovery of base-catalyzed retro-aza-Michael//aza-Michael isomerizations allowed the exploration of the chemical space by affording novel types of triazoles, difficult to obtain otherwise. Following this strategy, 2,4-disubstituted 1,2,3-triazoles could be efficiently obtained from the corresponding 1,4-disubstituted analogues.

  20. Michael Akam and the rise of evolutionary developmental biology

    PubMed Central

    Stern, David L.; Dawes-Hoang, Rachel E.

    2010-01-01

    Michael Akam has been awarded the 2007 Kowalevsky medal for his many research accomplishments in the area of evolutionary developmental biology. We highlight three tributaries of Michael’s contribution to evolutionary developmental biology. First, he has made major contributions to our understanding of development of the fruit fly, Drosophila melanogaster. Second, he has maintained a consistent focus on several key problems in evolutionary developmental biology, including the evolving role of Hox genes in arthropods and, more recently, the evolution of segmentation mechanisms. Third, Michael has written a series of influential reviews that have integrated progress in developmental biology into an evolutionary perspective. Michael has also made a large impact on the field through his effective mentorship style, his selfless promotion of younger colleagues, and his leadership of the University Museum of Zoology at Cambridge and the European community of evolutionary developmental biologists. PMID:20209429

  1. Markets, Marx, Modernity and Mathematics Education: A Response to Michael Apple.

    ERIC Educational Resources Information Center

    Gates, Peter

    This paper is a response to Michael Apple's paper, "What Postmodernists Forget: Cultural Capital and Official Knowledge." The paper advocates Michael's identification of the current dangers and processes of the growth of new right ideologies in the development of subjectivity, society, and education. The differences in success in the education…

  2. Michael Sadler and the German Connection.

    ERIC Educational Resources Information Center

    Higginson, J. H.

    1990-01-01

    Chronicles works of Michael Sadler who compared British and German educational systems, emphasizing Germany's contributions in technical education. Presents Sadler's 1912 recommendations--eight lessons premised upon powerful centralized government's ability to implement policy. Reflects on how World War I and Nazism influenced Sadler's thought and…

  3. Michael Polanyi: Science as Personal Knowledge and Social Practice.

    PubMed

    Nye, Mary Jo

    2017-03-20

    Tacit knowing: 2016 marked the 125th anniversary of the birth of the physical chemist Michael Polanyi, as well as the 40th of his death. This essay discusses his philosophy of science-in particular, his most significant work in this area, Personal Knowledge-from the perspective of his personal biography, as well as its lasting influence on the social sciences. In the photograph: Michael Polanyi at the Fritz Haber Institute in 1968. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Asymmetric Michael Addition Mediated by Chiral Ionic Liquids.

    PubMed

    Suzuki, Yumiko

    2018-06-01

    Chiral ionic liquids with a focus on their applications in asymmetric Michael additions and related reactions were reviewed. The examples were classified on the basis of the mode of asymmetric induction (e.g., external induction/non-covalent interaction or internal induction/covalent bond formation), the roles in reactions (as a solvent or catalyst), and their structural features (e.g., imidazolium-based chiral cations, other chiral oniums; proline derivatives). Most of the reactions with high chiral induction are Michael addition of ketones or aldehydes to chalcones or nitrostyrenes where proline-derived chiral ionic liquids catalyze the reaction through enamine/ iminium formation. Many reports demonstrate the recyclability of ionic liquid-tagged pyrrolidines.

  5. Michael Fisher at King's College London

    NASA Astrophysics Data System (ADS)

    Domb, Cyril

    1991-09-01

    Michael Fisher spent the first 16 years of his academic life in the Physics Department of King's College, London, starting as an undergraduate and ending as a full professor. A survey is undertaken of his activities and achievements during the various periods of this phase of his career.

  6. Michael Fisher at King's College London

    NASA Astrophysics Data System (ADS)

    Domb, Cyril

    Michael Fisher spent the first 16 years of his academic life in the Physics Department of King's College, London, starting as an undergraduate and ending as a full professor. A survey is undertaken of his activities and achievements during the various periods of this phase of his career.

  7. 75 FR 22436 - Michael Williams-Control Exemption-St. Maries River Railroad, Inc.

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [Docket No. FD 35365] Michael Williams-Control Exemption-St. Maries River Railroad, Inc. Michael Williams (applicant),\\1\\ a noncarrier, has filed a verified notice of exemption to acquire control of St. Maries River Railroad, Inc. (STMA), a Class...

  8. Far From ‘Easy’ Spectroscopy with the 8π and GRIFFIN Spectrometers at TRIUMF-ISAC

    NASA Astrophysics Data System (ADS)

    Garrett, P. E.; Radich, A. J.; Allmond, J. M.; Andreoiu, C.; Ball, G. C.; Bender, P. C.; Bianco, L.; Bildstein, V.; Bidaman, H.; Braid, R.; Burbadge, C.; Chagnon-Lessard, S.; Cross, D. S.; Deng, G.; Demand, G. A.; Diaz Varela, A.; Dunlop, M. R.; Dunlop, R.; Finlay, P.; Garnsworthy, A. B.; Grinyer, G. F.; Hackman, G.; Hadinia, B.; Ilyushkin, S.; Jigmeddorj, B.; Kisliuk, D.; Kuhn, K.; Laffoley, A. T.; Leach, K. G.; MacLean, A. D.; Michetti-Wilson, J.; Miller, D.; Moore, W.; Olaizola, B.; Orce, J. N.; Pearson, C. J.; Pore, J. L.; Rajabali, M. M.; Rand, E. T.; Sarazin, F.; Smith, J. K.; Starosta, K.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Turko, J.; Wang, Z. M.; Wood, J. L.; Wong, J.; Williams, S. J.; Yates, S. W.; Zganjar, E. F.

    2015-09-01

    The 8π spectrometer, installed at the TRIUMF-ISAC facility, was the world's most sensitive γ-ray spectrometer dedicated to β-decay studies. A description is given of the 8π spectrometer and its auxiliary detectors including the plastic scintillator array SCEPTAR used for β-particle tagging and the Si(Li) array PACES for conversion electron measurements, its moving tape collector, and its data acquisition system. The recent investigation of the decay of 124Cs to study the nuclear structure of 124Xe, and how the β-decay measurements complemented previous Coulomb excitation studies, is highlighted, including the extraction of the deformation parameters for the excited 0+ bands in 124Xe. As a by-product, the decay scheme of the (7+) 124Cs isomeric state, for which the data from the PACES detectors were vital, was studied. Finally, a description of the new GRIFFIN spectrometer, which uses the same auxiliary detectors as the 8π spectrometer, is given.

  9. Meet EPA Scientist Michael Nye, Ph.D.

    EPA Pesticide Factsheets

    Michael Nye, Ph.D., is a social scientist who studies natural risk, socio-demographic change and sustainable behavior. Prior to joining EPA, he worked for the UK Environment Agency in flood risk management and emergency preparedness

  10. Comments on Michael (1993): Establishing Operations

    ERIC Educational Resources Information Center

    Moore, J.

    2013-01-01

    The present comments concern Michael's concept of motivative variables, and the implications of that concept for our understanding of the nature of reinforcement as well as the extinction of responses maintained through positive and negative reinforcement. We note that both extinction and altering motivative variables decrease responding, but…

  11. Studying Teachers and Schools: Michael Pressley's Legacy and Directions for Future Research

    ERIC Educational Resources Information Center

    Mohan, Lindsey; Lundeberg, Mary A.; Reffitt, Kelly

    2008-01-01

    Much of Michael Pressley's work during the past decade focused on the nature of highly effective, engaging literacy instruction. Michael Pressley believed that studying effective teachers and schools had the potential to influence more engaging and effective teaching, especially in underresourced schools. First, we describe the grounded…

  12. Asymmetric Michael Addition Mediated by Chiral Ionic Liquids

    PubMed Central

    Suzuki, Yumiko

    2018-01-01

    Chiral ionic liquids with a focus on their applications in asymmetric Michael additions and related reactions were reviewed. The examples were classified on the basis of the mode of asymmetric induction (e.g., external induction/non-covalent interaction or internal induction/covalent bond formation), the roles in reactions (as a solvent or catalyst), and their structural features (e.g., imidazolium-based chiral cations, other chiral oniums; proline derivatives). Most of the reactions with high chiral induction are Michael addition of ketones or aldehydes to chalcones or nitrostyrenes where proline-derived chiral ionic liquids catalyze the reaction through enamine/ iminium formation. Many reports demonstrate the recyclability of ionic liquid-tagged pyrrolidines. PMID:29861702

  13. Michael Slote and "Sentimentalist Moral Education"

    ERIC Educational Resources Information Center

    Wren, Thomas

    2010-01-01

    Although I think most of what Michael Slote asserts in his article "Sentimentalist moral education" is correct, I worry about three important ideas that are conspicuous by their absence. The first is the possibility that human emotions and feelings are inherently cognitive, which is never considered in his psychological account of empathy. The…

  14. 77 FR 61596 - Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-10

    ...] Wheatley, Michael I.; Garrison, Drummond E.; Notice of Filing Take notice that on September 28, 2012, Michael I. Wheatley and Drummond E. Garrison submitted for filing, an application for authority to hold... the ``eFiling'' link at http://www.ferc.gov . Persons unable to file electronically should submit an...

  15. A Bibliographic Tribute to Jack Michael

    ERIC Educational Resources Information Center

    Esch, Barbara E.; Esch, John W.

    2016-01-01

    "In the late 1950's, Jack Michael, a bright but irritating young psychology instructor, moved from the Universities of Kansas to Houston to Arizona State. Along the way he befriended two nontraditional students, protected them through their Ph.D. programs, and turned them loose on the world: Teodoro Ayllon…and Montrose Wolf…" (Risley,…

  16. Microbial quality of soft drinks served by the dispensing machines in fast food restaurants and convenience stores in Griffin, Georgia, and surrounding areas.

    PubMed

    Park, Yoen Ju; Chen, Jinru

    2009-12-01

    This study was undertaken to evaluate the microbial quality of the soft drinks served by fast food restaurants and gas station convenience stores in Griffin, GA, and surrounding areas. The soft drinks were collected from the dispensing machines in 8 fast food restaurants or gas station convenience stores in 2005 (n = 25) and in 10 fast food restaurants or gas station convenience stores in 2006 (n = 43) and 2007 (n = 43). One hundred milliliters of each soft drink was filtered through a hydrophobic grid membrane filter. The remaining portion of the soft drink was kept at room temperature for 4 h before sampling in order to mimic the possible holding time between purchase and consumption. The membrane filters were sampled for total aerobic bacteria, Enterobacteriaceae, lactic acid bacteria, and yeasts and molds. The microbial counts in the 2006 samples were numerically higher than the counts in the 2007 samples except for the average lactic acid bacteria counts, and were either significantly or numerically higher than the counts in the 2005 samples. Soft drinks sampled after the 4-h holding period had relatively higher counts than those sampled initially, with a few exceptions. Some soft drinks had over 4 log CFU/100 ml of total aerobic bacteria, Enterobacteriaceae, lactic acid bacteria, and yeast and mold cells. The study revealed the microbial quality of soft drinks served by dispensing machines in Griffin, GA, and surrounding areas, emphasizing the importance of effective sanitizing practice in retail settings.

  17. Meet EPA Ecologist Michael Murrell, Ph.D.

    EPA Pesticide Factsheets

    Michael Murrel, Ph.D., is a EPA research ecologist working on the Gulf of Mexico Hypoxia Project, helping develop models of the northern Gulf to quantify the links between freshwater flowing into the Gulf from the land, nutrients, and hypoxia—“dead zones”

  18. 76 FR 55904 - Michael J. Donahue; Notice of Termination of Exemption By Implied Surrender and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 6649-008] Michael J.... Date Initiated: September 1, 2011. d. Exemptee: Michael J. Donahue. e. Name and Location of Project.... Initiated Pursuant to: 18 CFR 4.106. g. Exemptee Contact Information: Mr. Michael J. Donahue, Route 3, Box...

  19. 76 FR 58264 - Michael J. Donahue; Notice of Termination of Exemption by Implied Surrender and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 6649-008] Michael J.... Date Initiated: September 13, 2011. d. Exemptee: Michael J. Donahue. e. Name and Location of Project.... Initiated Pursuant to: 18 CFR 4.106. g. Exemptee Contact Information: Mr. Michael J. Donahue, Route 3, Box...

  20. 75 FR 62635 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request... determine patients' satisfaction with services provided by or through the Michael E. DeBakey Home Care...: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number...

  1. 77 FR 69550 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-19

    ... (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request AGENCY... information needed to determine patients' satisfaction with services provided by or through the Michael E...: Patient Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number...

  2. Surface Modified Particles By Multi-Step Michael-Type Addition And Process For The Preparation Thereof

    DOEpatents

    Cook, Ronald Lee; Elliott, Brian John; Luebben, Silvia DeVito; Myers, Andrew William; Smith, Bryan Matthew

    2005-05-03

    A new class of surface modified particles and a multi-step Michael-type addition surface modification process for the preparation of the same is provided. The multi-step Michael-type addition surface modification process involves two or more reactions to compatibilize particles with various host systems and/or to provide the particles with particular chemical reactivities. The initial step comprises the attachment of a small organic compound to the surface of the inorganic particle. The subsequent steps attach additional compounds to the previously attached organic compounds through reactive organic linking groups. Specifically, these reactive groups are activated carbon—carbon pi bonds and carbon and non-carbon nucleophiles that react via Michael or Michael-type additions.

  3. Organization as Information Processing Systems. Toward a Model of the Research Factors Associated with Significant Research Outcomes.

    DTIC Science & Technology

    1986-04-01

    of Management DT1, Texas A&M University E LE C I - "-MAY 27 M6 Richard Daft and * E Ricky Griffin r|DJ rEN . T 1o SltM - t Principal Investigators...Department of Management College of Business Administration Texas A&M University College Station, TX 77843 TR-ONR-DG-01 Joe Thomas and Ricky W. Griffin...and Use of Formal Control Systems for Management Control and Strategy Implementation. February 1984. TR-ONR-DG-07 Thomas Head, Ricky W. Griffin, and

  4. Solving the Housing Equation: Michael P. Johnson

    ERIC Educational Resources Information Center

    Roach, Ronald

    2005-01-01

    Dr. Michael P. Johnson, an associate professor of management science and urban affairs at the H. John Heinz III School of Public Policy and Management at Carnegie Mellon University in Pittsburgh, is taking management science tools and innovative information technology applications to the housing field. Concerned that organizations that develop and…

  5. "Anti-Michael addition" of Grignard reagents to sulfonylacetylenes: synthesis of alkynes.

    PubMed

    Esteban, Francisco; Boughani, Lazhar; García Ruano, José L; Fraile, Alberto; Alemán, José

    2017-05-10

    In this work, the addition of Grignard reagents to arylsulfonylacetylenes, which undergoes an "anti-Michael addition", resulting in their alkynylation under very mild conditions is described. The simplicity of the experimental procedure and the functional group tolerance are the main features of this methodology. This is an important advantage over the use of organolithium at -78 °C that we previously reported. Moreover, the synthesis of diynes and other examples showing functional group tolerance in this anti-Michael reaction is also presented.

  6. Reframing Michael Scott: Exploring Inappropriate Workplace Communication

    ERIC Educational Resources Information Center

    Schaefer, Zachary A.

    2010-01-01

    Individuals who work in professional settings interact with others who may exhibit a variety of cultural beliefs and decision-making approaches. Page (2007) argues that cognitive diversity (i.e., how people approach and attempt to solve problems) is a vital asset in effective organizations. Michael Scott, who portrays the inept main character on…

  7. Against Dogma: A Reply to Michael Swan.

    ERIC Educational Resources Information Center

    Widdowson, H. G.

    1985-01-01

    Replies to two articles by Michael Swan entitled "A Critical Look at the Communicative Approach." Argues that Swan presents a distorted version of the communicative approach so as to present his own ideas more effectively and that he fails to offer evidence for his position on the practice of English language teaching. (SED)

  8. The legacy of Michael Balint.

    PubMed

    Johnson, Alan H; Brock, Clive D; Zacarias, Ashleigh

    2014-01-01

    Michael Balint's lead article, "Repeat Prescription Patients: Are They An Identifiable Group?" inaugurated the first issue of Psychiatry in Medicine, Vol. 1, No. 1, 1970. A few years later, this Journal would be renamed International Journal of Psychiatry in Medicine (IJPM). Who is this author of over 165 papers, 10 books, practicing psychoanalyst from 1926 to 1970, director of the Budapest Psychoanalytic Institute from 1935 to 1939, consultant at the Tavistock Clinic from 1948 to 1961, President of the British Psycho-Analytical Society from 1968 to 1970, literary executor of Sandor Ferenczi, a foremost theorist of object relations, and international educator and statesman for general practitioners? We would like to review for you some of the formative experiences in Michael's life that wedded psychoanalysis and general practice, and how they contributed to his major educational commitment over 40 years to furthering the understanding and integration of psychosocial factors in the practice of primary healthcare as experienced by doctors all over the world. We would also like to highlight some of his major insights and see to what extent they are incorporated in contemporary medical education and practice. We believe that some of his major insights have been neglected and others have been further amplified and extended. Our intention is to speak not only to medical students who desire to pursue medicine related directly to patient care but as well to seasoned practitioners who continue on a daily basis to care for individual patients and their families.

  9. MICHAEL "RUDI" RUDOLPHI SPEAKING AT MISSION SUCCESS FORUM

    NASA Image and Video Library

    2016-06-16

    MICHAEL "RUDI" RUDOLPHI GESTURES DURING A "MISSION SUCCESS IS IN OUR HANDS" SHARED EXPERIENCES FORUM JUNE 16, WHERE HE SPOKE ABOUT HIS "UNFORGETTABLE" EXPERIENCES AS A SENIOR NASA REPRESENTATIVE OVERSEEING DEBRIS RECOVERY EFFORTS FOLLOWING THE LOSS OF SPACE SHUTTLE COLUMBIA AND ITS CREW.

  10. TISSUE DISPOSITION OF DIMETHYLARSINIC ACID IN THE MOUSE AFTER ACUTE ORAL ADMINISTRATION

    EPA Science Inventory

    TISSUE DISPOSITION OF DIMETHYLARSINIC ACID IN THE MOUSE
    AFTER ACUTE ORAL ADMINISTRATION

    Michael
    F. Hughes, Ph.D., Brenda C. Edwards, Carol T. Mitchell and Elaina M. Kenyon, Ph.D. United States Environmental Protection Agency, Office of Research and Development, Nation...

  11. Michael Driver: A Career Life to Remember

    ERIC Educational Resources Information Center

    Sundby, Dianne; Derr, C. Brooklyn

    2007-01-01

    Purpose: The purpose of this paper is to present a retrospective of the career life of Michael Driver, from the time of his Princeton graduate studies and early faculty years at Purdue University through the over three decades he spent at USC. Design/methodology/approach: The history and development of his theoretical and research interests are…

  12. Michael Walzer's Politics, in Theory and Practice

    ERIC Educational Resources Information Center

    Williams, Jeffrey J.

    2012-01-01

    Before all the talk about "public intellectuals," Michael Walzer was one. For 50 years, he has gone back and forth between positions at Princeton and Harvard Universities and then at the Institute for Advanced Study, in Princeton, New Jersey, where he is now emeritus. His writings appear regularly in "Dissent" magazine, which he has co-edited for…

  13. KSC-08pd0149

    NASA Image and Video Library

    2008-02-01

    KENNEDY SPACE CENTER, FLA. -- At the NASA's Kennedy Space Center Visitor Complex, NASA Administrator Michael Griffin (left) and Indian Space Research Organization Chairman G. Madhavan Nair show their pleasure after signing a framework agreement establishing the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

  14. KSC-08pd0148

    NASA Image and Video Library

    2008-02-01

    KENNEDY SPACE CENTER, FLA. -- At a ceremony at the NASA's Kennedy Space Center Visitor Complex, NASA Administrator Michael Griffin (left) and Indian Space Research Organization Chairman G. Madhavan Nair sign a framework agreement establishing the terms for future cooperation between the two agencies in the exploration and use of outer space for peaceful purposes. According to the framework agreement, the two agencies will identify areas of mutual interest and seek to develop cooperative programs or projects in Earth and space science, exploration, human space flight and other activities. In addition to a long history of cooperation in Earth science, NASA and the Indian Space Research Organization also are cooperating on India's first, mission to the moon, Chandrayaan-1, which will be launched later this year. NASA is providing two of the 11 instruments on the spacecraft: the moon mineralogy mapper instrument and the miniature synthetic aperture radar instrument. Photo credit: NASA/Kim Shiflett

  15. Reading Michael Apple--The Sociological Imagination at Work

    ERIC Educational Resources Information Center

    Ball, Stephen J.

    2007-01-01

    This article discusses Michael Apple's contribution to the sociology of education and education policy analysis and the politics of education. It focuses on ways of "reading" Apple as an intellectual and an activist and looks at the trajectory of his work over a long and illustrious career.

  16. Production of Low-Freezing-Point Highly Branched Alkanes through Michael Addition.

    PubMed

    Jing, Yaxuan; Xia, Qineng; Liu, Xiaohui; Wang, Yanqin

    2017-12-22

    A new approach for the production of low-freezing-point, high-quality fuels from lignocellulose-derived molecules was developed with Michael addition as the key step. Among the investigated catalysts, CoCl 2 ⋅6 H 2 O was found most active for the Michael addition of 2,4-pentanedione with FA (single aldol adduct of furfural and acetone, 4-(2-furanyl)-3-butene-2-one). Over CoCl 2 ⋅6 H 2 O, a high carbon yield of C 13 oxygenates (about 75 %) can be achieved under mild conditions (353 K, 20 h). After hydrodeoxygenation, low-freezing-point (<223 K) branched alkanes with 13 carbons within jet fuel ranges were obtained over a Pd/NbOPO 4 catalyst. Furthermore, C 18,23 fuel precursors could be easily synthesized through Michael addition of 2,4-pentanedione with DFA (double-condensation product of furfural and acetone) under mild conditions and the molar ratio of C 18 /C 23 is dependent on the reaction conditions of Michael addition. After hydrodeoxygenation, high density (0.8415 g mL -1 ) and low-freezing-point (<223 K) branched alkanes with 18, 23 carbons within lubricant range were also obtained over a Pd/NbOPO 4 catalyst. These highly branched alkanes can be directly used as transportation fuels or additives. This work opens a new strategy for the synthesis of highly branched alkanes with low freezing point from renewable biomass. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  17. Astronaut Michael Clifford takes a break during bailout training

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Astronaut Michael R.U. (Rich) Clifford takes a break while video taping crew mates in training in the JSC Weightless Environment Training Facility (WETF). He is pictured with Trent G. Keeple, a member of the training staff assigned to STS-59.

  18. Michael Hand, Indoctrination and the Inculcation of Belief

    ERIC Educational Resources Information Center

    Tan, Charlene

    2004-01-01

    In 'Religious Upbringing Reconsidered,' Michael Hand revisits the debate on the right of parents to give their children a religious upbringing in a liberal context. According to him, the logical difficulty lies in the fact that parents cannot both impart religious beliefs and avoid indoctrination. While Peter Gardner and Jim Mackenzie have…

  19. Race, punishment, and the Michael Vick experience.

    PubMed

    Piquero, Alex R; Piquero, Nicole Leeper; Gertz, Marc; Baker, Thomas; Batton, Jason; Barnes, J C

    2011-01-01

    Objective. The relationship between race and crime has been contentious, focusing primarily on offending and incarceration patterns among minorities. There has been some limited work on public perceptions of criminal punishment, and findings show that while minorities believe in the role and rule of law, they simultaneously perceive the justice system as acting in a biased and/or unfair manner. Two limitations have stalled this literature. First, research has focused mainly on criminal punishments to the neglect of noncriminal punishments. Second, most studies have not examined whether race remains salient after considering other demographic variables or discrimination and legitimacy attitudes.Methods. Using data from 400 adults, we examine how race affects perceptions of criminal punishment and subsequent reinstatement into the National Football League in the case of Michael Vick, a star professional quarterback who pled guilty to charges of operating an illegal dog-fighting ring.Results. Findings show that whites are more likely to view Vick's punishment as too soft and that he should not be reinstated, while nonwhites had the opposite views. Race remained significant after controlling for other variables believed to be related to punishment perceptions.Conclusion. Attitudes toward both criminal punishment and NFL reinstatement vary across race such that there exists important divides in how individuals perceive the system meting out punishment and subsequently reintegrating offenders back into society. These results underscore that white and nonwhites perceive the law and its administration differently.

  20. 76 FR 624 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-05

    ... Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request... Form 10-0476).'' SUPPLEMENTARY INFORMATION: Title: Patient Satisfaction Survey Michael E. DeBakey Home... satisfaction with the quality of services/care provided by home care program staff. An agency may not conduct...

  1. The Holocaust and Education: An Interview with Michael Berenbaum.

    ERIC Educational Resources Information Center

    Goldberg, Mark

    1997-01-01

    In January 1997, Michael Berenbaum became president and chief executive officer of Survivors of the Shoah Visual History Foundation, the organization established by filmmaker Steven Spielberg after completing "Schindler's List." Since 1994, the foundation has been recording eyewitness testimony on the Holocaust. Berenbaum's mandate is to…

  2. Dr. Michael DeBakey "is a magician of the heart…"

    MedlinePlus

    ... Dr. DeBakey with NLM's David Nash and admiring students from the Michael E. DeBakey High School for ... medical research as the means of discovering improved methods of diagnosis, treatment, prevention, and cure. As far ...

  3. 78 FR 6851 - Proposed Information Collection (Patient Satisfaction Survey Michael E. DeBakey Home Care Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... (Patient Satisfaction Survey Michael E. DeBakey Home Care Program) Activity: Comment Request AGENCY... Satisfaction Survey Michael E. DeBakey Home Care Program, VA Form 10-0476. OMB Control Number: 2900-0775. Type... gather feedback from patients regarding their satisfaction with the quality of services/care provided by...

  4. Michael Polanyi on the Education and Knowledge of Scientists.

    ERIC Educational Resources Information Center

    Jacobs, Struan

    2000-01-01

    Explains why teachers addressing the nature of science should know the work of Michael Polanyi. Outlines Polanyi's intellectual career and examines his ideas on the education of scientists, research, and knowledge. Polanyi presaged Kuhn, Feyerabend, and the constructivists, yet insisted that science produces true knowledge about reality. (Contains…

  5. Tweeting Prayers and Communicating Grief over Michael Jackson Online

    ERIC Educational Resources Information Center

    Sanderson, Jimmy; Cheong, Pauline Hope

    2010-01-01

    Death and bereavement are human experiences that new media helps facilitate alongside creating new social grief practices that occur online. This study investigated how people's postings and tweets facilitated the communication of grief after pop music icon Michael Jackson died. Drawing on past grief research, religion, and new media studies, a…

  6. 75 FR 4552 - Clean Water Act Class II: Proposed Administrative Settlement, Penalty Assessment, and Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-28

    ... CONTACT: Michael Calhoun, Special Litigation and Projects Division (2248-A), U.S. Environmental Protection...-9001; e-mail: calhoun[email protected] . SUPPLEMENTARY INFORMATION: I. Background In July 2005, Hydro... supplemental audit reports in 2006 and 2007. EPA and Hydro have signed an administrative Consent Agreement...

  7. A Good Time: A Conversation with C. Michael Nelson

    ERIC Educational Resources Information Center

    Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

    2015-01-01

    C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

  8. Aza-Michael Reaction for an Undergraduate Organic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Nigam, Manisha; Rush, Brittney; Patel, Jay; Castillo, Raul; Dhar, Preeti

    2016-01-01

    A green, aza-Michael reaction is described that can be used to teach undergraduate students conjugate addition of nitrogen nucleophile to an a,ß-unsaturated ester. Students analyze spectral data of the product obtained from the assigned reaction to determine product structure and propose the mechanism of its formation. The experiment requires…

  9. What Works, Works Everywhere: Q&A with Michael Barber

    ERIC Educational Resources Information Center

    Crow, Tracy

    2009-01-01

    This article presents an interview with Michael Barber, a partner at McKinsey & Company, leading its global education practice. He has been working on major challenges of performance, organization, and reform in government and the public services, especially education, in the U.S., U.K., and other countries. Barber was instrumental in preparing…

  10. Michael J. Fox and his Parkinson's disease.

    PubMed

    Kempster, Peter A

    2004-01-01

    Michael J. Fox was a popular and successful film and television comic actor who developed Parkinson's disease at the age of 29 years. His recently published book, Lucky Man, structured around the story of his Parkinson's disease, is an amusing, briskly paced yet introspective memoir that covers the first 40 years of his life. Although quite anecdotal, it contains interesting observations on the preclinical phase of the disorder, evolution of motor fluctuations, and tactics for pharmacological treatment. Copyright 2003 Movement Disorder Society

  11. Substrate Variations and its Relationship and Impact on the Distribution of Eelgrass Beds in Griffin Bay, Washington

    NASA Astrophysics Data System (ADS)

    Sopha, A.; Greene, H.; Wyllie-Echeverria, S.; Harmsen, F. J.

    2010-12-01

    Eelgrass is considered an important indicator species for the health of the oceans; it provides nearshore habitat to many marine organisms and also acts as a source of protection for migrating populations of juvenile salmon and other fish species including forage fish. Since the late 1980s, there has been a drastic decline in eelgrass beds within the surrounding marine areas of Washington State; specifically in the species Zostera marina. Previous studies have focused on potential impacts such as bacterial infections and loss of sunlight from docks, shoreline tree canopy overgrowth and permanently anchored boats. In specific locations, sawmill waste has prevented the regeneration of eelgrass. In this study, sediment samples, along with video transects, were collected from Griffin Bay, Washington, located within the San Juan Archipelago to determine if substrate conditions have any impact on the distribution, appearance, disappearance, and health of the eelgrass beds. Initial findings indicate that in fact, eelgrass is increasing with growth beyond the area in which their distribution was previously documented. This is in contrast to other areas where eelgrass is in decline. Final results have yet to be analyzed.

  12. [An exceptional human relationship (Michael P. Kierkegaard, Søren Kierkegaard)].

    PubMed

    Jacobs, R

    1978-01-01

    There were a father and a son, Michael and Sören Kierkegaard, both highly talented, imaginitive, witty, humorous, especially interested in shrewd dialectrical dialogues respectively debates, both profound melancholy ponderers. But according to very own individuality their congeniality wasn't absolute. The father, being under a questionable rigorous opinion of sin, suffered from undeserved divine grace since early childhood. And Michael Kierkegaard made Sören anxious with the religious experience of original sin. This anxiety moved (touched or affected) the sensitive son mighty. Nevertheless he should not despair hopelessly like his unlucky father. On the contrary: Sørens incomparable melancholy, mental agony and anxiety (fear or anguish) forced the faith, existing independently of them, in a radical refining. That is why Sören Kierkegaard succeeded in sublimation of all psychological and philosophic (al) attitudes (or opinions) in the sphere of religiousness. And the result? A novel philosophy of life: Christian existentialism.

  13. KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush at NASA Headquarters in Washington, D.C., stating his goals for NASA’s new mission: Completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

    NASA Image and Video Library

    2004-01-14

    KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush at NASA Headquarters in Washington, D.C., stating his goals for NASA’s new mission: Completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

  14. HEADSTONES OF BERNARD AND MICHAEL JODD, FATHERANDSON CIVILIANS RESPONSIBLE FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HEADSTONES OF BERNARD AND MICHAEL JODD, FATHER-AND-SON CIVILIANS RESPONSIBLE FOR CONSTRUCTION OF BRICK PERIMETER WALL WHO DIED OF YELLOW FEVER DURING WALL CONSTRUCTION. VIEW TO WEST. - Baton Rouge National Cemetery, 220 North 19th Street, Baton Rouge, East Baton Rouge Parish, LA

  15. New Models at Lasell: Q&A with President Michael Alexander

    ERIC Educational Resources Information Center

    Harney, John O.

    2018-01-01

    The "New England Journal of Higher Education" ("NEJHE") Executive Editor John O. Harney had the chance to catch up with Lasell College President Michael Alexander about the small Newton, Massachusetts, college's plans to challenge the higher education business model. The interview is presented in this article.

  16. Michael M. May: Working toward solutions

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    May, M.M.

    1993-07-01

    As part of LLNL's 40th anniversary celebration held during 1992, the six former Directors were asked to participate in a lecture series. Each of these men contributed in important ways toward making the Lawrence Livermore National Laboratory (LLNL) what it has become today. Each was asked to comment on some of the Laboratory's accomplishments, his career here, his view of the changing world, and where he sees the Laboratory going in the future. Michael M. May, LLNL's fifth Director and now a Director Emeritus, comments on a broad range of issues including arms control, nonproliferation, cooperative security, and the futuremore » role of the Laboratory.« less

  17. 2016 Summer Series - Michael Flynn - Synthetic Biological Membrane

    NASA Image and Video Library

    2016-08-02

    Full understanding leads to creation capability, which results in customization capacity. Synthetic biology uses our knowledge of biology to engineer novel biological devices or organisms that can perform tasks not found in nature. For Human space exploration, synthetic biology approaches will reduce risk, mass carried and increase Human reach. Michael Flynn will discuss the International Space Station (ISS) water recycling and his current work on developing a water filtration system capable of self-repair.

  18. 78 FR 2391 - CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. RP13-436-000] CAlifornians for Renewable Energy, Inc., Michael E. Boyd, Robert M. Sarvey v. Pacific Gas and Electric Company... Energy Regulatory Commission (FERC); CAlifornians for Renewable Energy, Inc., Michael E. Boyd, and Robert...

  19. STS-34 Pilot Michael J. McCulley uses ARRIFLEX camera equipment

    NASA Image and Video Library

    1989-04-13

    STS-34 Atlantis, Orbiter Vehicle (OV) 104, Pilot Michael J. McCulley squints while looking through ARRIFLEX camera eye piece during camera briefing at JSC. McCulley rests part of the camera on his shoulder as he operates it.

  20. Game Plan

    NASA Technical Reports Server (NTRS)

    Morring, Frank, Jr.

    2005-01-01

    Industry proposals for the Crew Exploration Vehicle that NASA plans as a replacement for the space shuttle are due next week, but the agency's new chief says it might be necessary to slow the CEV procurement at first to speed it up later. After a quick trip to Kennedy Space Center for briefings on getting the space shuttle back in operation, Michael D. Griffin sat down with his growing staff last week to begin work on modifying the CEV procurement. "We are going to rethink our entire program in that area," he said during an inaugural press conference Apr. 18. The proposals due May 2 are being prepared in response to NASA's call for a "risk-reduction flight effort" in 2008 that would lead to delivery of a human-rated CEV in 2014. But Griffin was co-leader on an independent study in 2004 that recommended a way to get the CEV flying astronauts in 2010, the year President Bush has set as a deadline for retiring the space shuttle fleet. In that study, produced for The Planetary Society, Griffin and his team called for development of a 13-15-ton "Block 1" CEV limited to low Earth orbit (LEO) that would be launched atop a single space shuttle solid rocket motor (SRM), with a new cryogenic upper stage based on existing rocket engine technology, Under this approach, NASA would develop a "Block 2" CEV later for human exploration beyond LEO.

  1. Educational Implications of Michael Fishbane's "Sacred Attunement: A Jewish Theology"

    ERIC Educational Resources Information Center

    Marom, Daniel

    2008-01-01

    This article posits Michael Fishbane's Judaic scholarship as a prime resource for Jewish education. The link between the two fields can be made through a translation of the theological underpinnings of Fishbane's insights into Judaism to educational purposes and practices. Initial work with Jewish educators on establishing this link encouraged…

  2. A Proposed Integration among Organizational Information Requirements, Media Richness and Structural Design.

    DTIC Science & Technology

    1984-11-01

    34 ’-" " " ’ " " . 2:;.- " 2 ’. - - . *" " 9 0 .0 o A Proposed Integration Among Organizational Information Requirements, Media Richness and Structural...Business Administration Texas A&M University " College Station, TX 77843 0 TR-ONR-DG-01 Joe Thomas and Ricky W. Griffin. The Social Information...Approach to Managerial Behavior and Organization Design. May 1983. TR-ONR-DC-03 Ricky W. Griffin, Thomas S. Bateman, and James Skivington. Social Cues

  3. COMPARATIVE METABOLISM OF ARSENIC IN MICE AFTER A SINGLE OR REPEATED ORAL ADMINISTRATION OF ARSENATE

    EPA Science Inventory

    COMPARATIVE METABOLISM OF ARSENIC IN MICE AFTER A SINGLE OR REPEATED ORAL ADMINISTRATION OF ARSENATE
    Michael F. Hughes*1, Elaina M. Kenyon1, Brenda C. Edwards1, Carol T. Mitchell1, Luz Maria Del Razo2 and David J. Thomas1
    1US EPA, ORD, NHEERL, ETD, PKB, Research Triangle Pa...

  4. 77 FR 30047 - Notice of Opportunity for Public Comment on Surplus Property Release at Michael J Smith Field...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Comment on Surplus Property Release at Michael J Smith Field, Beaufort, NC AGENCY: Federal Aviation... J Smith Field, be used for aeronautical purposes. DATES: Comments must be received on or before June... property at the Michael J Smith Field. The property consists of one parcel located on the north side of...

  5. KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) tours a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) tours a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  6. Michael Faraday on the Learning of Science and Attitudes of Mind.

    ERIC Educational Resources Information Center

    Crawford, Elspeth

    1998-01-01

    Makes use of Michael Faraday's ideas on learning, focusing on his attitudes toward the unknowns of science and the development of an attitude that improves scientific decision making. This approach acknowledges that there is an inner struggle involved in facing unknowns. (DDR)

  7. 29 CFR Appendix A to Part 71 - Responsible Officials

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Policy Development & Research Administrator, Office of Financial & Administrative Management Director... Research Director, Operations Office of the Inspector General (OIG) Disclosure Officer Office of Public... Griffin Street, Suite 800, Dallas, TX 75202 Western Region 71 Stevenson Street, Suite 930, San Francisco...

  8. 29 CFR Appendix A to Part 71 - Responsible Officials

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Policy Development & Research Administrator, Office of Financial & Administrative Management Director... Research Director, Operations Office of the Inspector General (OIG) Disclosure Officer Office of Public... Griffin Street, Suite 800, Dallas, TX 75202 Western Region 71 Stevenson Street, Suite 930, San Francisco...

  9. 29 CFR Appendix A to Part 71 - Responsible Officials

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Policy Development & Research Administrator, Office of Financial & Administrative Management Director... Research Director, Operations Office of the Inspector General (OIG) Disclosure Officer Office of Public... Griffin Street, Suite 800, Dallas, TX 75202 Western Region 71 Stevenson Street, Suite 930, San Francisco...

  10. 29 CFR Appendix A to Part 71 - Responsible Officials

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Policy Development & Research Administrator, Office of Financial & Administrative Management Director... Research Director, Operations Office of the Inspector General (OIG) Disclosure Officer Office of Public... Griffin Street, Suite 800, Dallas, TX 75202 Western Region 71 Stevenson Street, Suite 930, San Francisco...

  11. 29 CFR Appendix A to Part 71 - Responsible Officials

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Policy Development & Research Administrator, Office of Financial & Administrative Management Director... Research Director, Operations Office of the Inspector General (OIG) Disclosure Officer Office of Public... Griffin Street, Suite 800, Dallas, TX 75202 Western Region 71 Stevenson Street, Suite 930, San Francisco...

  12. Chemopreventive Agents from Physalis minima Function as Michael Reaction Acceptors

    PubMed Central

    Men, Ruizhi; Li, Ning; Ding, Chihong; Tang, Yingzhan; Xing, Yachao; Ding, Wanjing; Ma, Zhongjun

    2016-01-01

    Background: The fruits of some varieties of genus Physalis have been used as delicious fruits and functional food in the Northeast of China. Materials and Methods: To reveal the functional material basis, we performed bioactivity-guided phytochemical research and chemopreventive effect assay of the constituents from Physalis minima. Results: It was demonstrated that the ethyl acetate extract of P. minima L. (EEPM) had potential quinone reductase (QR) inducing activity with induction ratio (IR, QR induction activity) value of 1.47 ± 0.24, and glutathione binding property as potential Michael reaction acceptors (with an α, β-unsaturated ketone moiety). Furthermore, bioactivity-guided phytochemical research led eight compounds (1–8), which were elucidated as 3-isopropyl-5-acetoxycyclohexene-2-one-1 (1), isophysalin B (2), physalin G (3), physalin D (4), physalin I (5), physordinose B (6), stigmasterol-3-O-β-D-glucopyranoside (7) and 5α-6β-dihydroxyphysalin R (8) on the basis of nuclear magnetic resonance spectroscopy analyses and HRESIMS. Then, isophysalin B (2) and physordinose B (6) showed significant QR inducing activity with IR value of 2.80 ± 0.19 and 2.38 ± 0.46, respectively. SUMMARY An ultra-performance liquid chromatographic method with glutathione as the substrate was used to detect the Michael reaction acceptors in extracts of Physalis minima (EPM)We investigated the chemical constituents of EPM guided by biological activity methodIsophysalin B (1) and physordinose B (6) showed strong quinone reductase inducing activity with induction ratio values of 2.80 ± 0.19 and 2.38 ± 0.46This study generated useful information for consumers and many encourage researchers to utilize edible fruits from Physalis as a source of phytochemicals Abbreviations used: EPM: Extracts of Physalis minima, EEPM: Ethyl acetate extract of Physalis minima L., GSH: Glutathione, MRAs: Michael reaction acceptors, QR: Quinone reductase. PMID:27279713

  13. Michael Young's "The Rise of the Meritocracy": A Philosophical Critique

    ERIC Educational Resources Information Center

    Allen, Ansgar

    2011-01-01

    This paper examines Michael Young's 1958 dystopia, "The Rise of the Meritocracy". In this book, the word "meritocracy" was coined and used in a pejorative sense. Today, however, meritocracy represents a positive ideal against which we measure the justice of our institutions. This paper argues that, when read in the twenty-first century, Young's…

  14. On Happiness and High Achievement: An Interview with Michael Thompson

    ERIC Educational Resources Information Center

    National Association of Independent Schools (NAIS) (NJ), 2006

    2006-01-01

    Michael G. Thompson knows independent schools. He attended them in elementary and secondary school, and has worked in them as a psychologist. He consults with more than 30 schools a year, addressing a myriad of issues related to complex human interaction. He has written often in "Independent School" about everything from understanding the social…

  15. Passings to note: Paul Michael Packman, MD; S. Charles Schulz, MD.

    PubMed

    Black, Donald W

    2018-02-01

    One of the keys to the success of Annals of Clinical Psychiatry has always been the tireless efforts of our dedicated Editorial Board. We recently lost 2 longtime Editorial Board members, Drs. Paul Michael Packman and S. Charles Schulz. Both will be greatly missed.

  16. Shaping the Global Civil Society: An Interview with Michael Peters

    ERIC Educational Resources Information Center

    Heraud, Richard; Tesar, Marek

    2017-01-01

    Professor Michael A. Peters has worked in an era of transformation that has taken him from a labour-intensive paper-based form of production to the computerised reproduction of thought, and the current shift in the publishing landscape from a reader-subscription to an author-pays model. Most of what he has learned in publishing and editing he has…

  17. Michael E. Barnes: Award for Distinguished Professional Contributions to Institutional Practice

    ERIC Educational Resources Information Center

    American Psychologist, 2012

    2012-01-01

    Presents a short biography on the winner of the American Psychological Association's Award for Distinguished Professional Contributions to Institutional Practice. The 2012 winner is Michael E. Barnes for his pioneering leadership, dedication, and distinguished contributions to juvenile justice. As chief psychologist of the Superior Court of the…

  18. Q & A with Ed Tech Leaders: Interview with J. Michael Spector

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Fulgham, Susan M.

    2015-01-01

    J. Michael Spector's academic preparation was in philosophy--epistemology and logic, primarily. His dissertation was on skepticism in modern philosophy, and that led him to a deep-seated appreciation for classical skepticism. The word "skeptic" is derived from the Greek word "skepsis," which means investigation. While the…

  19. The power of virtual integration: an interview with Dell Computer's Michael Dell. Interview by Joan Magretta.

    PubMed

    Dell, M

    1998-01-01

    Michael Dell started his computer company in 1984 with a simple business insight. He could bypass the dealer channel through which personal computers were then being sold and sell directly to customers, building products to order. Dell's direct model eliminated the dealer's markup and the risks associated with carrying large inventories of finished goods. In this interview, Michael Dell provides a detailed description of how his company is pushing that business model one step further, toward what he calls virtual integration. Dell is using technology and information to blur the traditional boundaries in the value chain between suppliers, manufacturers, and customers. The individual pieces of Dell's strategy--customer focus, supplier partnerships, mass customization, just-in-time manufacturing--may be all be familiar. But Michael Dell's business insight into how to combine them is highly innovative. Direct relationships with customers create valuable information, which in turn allows the company to coordinate its entire value chain back through manufacturing to product design. Dell describes how his company has come to achieve this tight coordination without the "drag effect" of ownership. Dell reaps the advantages of being vertically integrated without incurring the costs, all the while achieving the focus, agility, and speed of a virtual organization. As envisioned by Michael Dell, virtual integration may well become a new organizational model for the information age.

  20. Michael K. Scullin: Psi Chi/APA Edwin B. Newman Graduate Research Award.

    PubMed

    2011-11-01

    Presents Michael K. Scullin as the 2011 winner of the American Psychological Association Psi Chi/APA Edwin B. Newman Graduate Research Award. "For an outstanding research paper that examines the relationship between prospective memory in executing a goal and various lapses of time from 20 minutes up to a 12- hour wake delay and a 12-hour sleep delay. The results suggest that consolidation processes active during sleep increase the probability of goal execution. The paper, titled 'Remembering to Execute a Goal: Sleep On It!' was published in Psychological Science in 2010 and was the basis for Michael K. Scullin's selection as the recipient of the 2011 Psi Chi/APA Edwin B. Newman Graduate Research Award. Mark A. McDaniel, PhD, served as faculty research advisor." (PsycINFO Database Record (c) 2011 APA, all rights reserved). 2011 APA, all rights reserved

  1. Searching phase II enzymes inducers, from Michael acceptor-[1,2]dithiolethione hybrids, as cancer chemopreventive agents.

    PubMed

    Couto, Marcos; de Ovalle, Stefani; Cabrera, Mauricio; Cerecetto, Hugo; González, Mercedes

    2015-01-01

    Cancer chemoprevention involves the carcinogenic process prevention, delay or reverse by the administration of chemopreventive agents, which are able to suppress or block the carcinogen metabolic activation/formation. The increased activity of phase II detoxification enzymes such as quinone-reductase (QR) and glutation-S-transferase (GST) correlates with the protection against chemically-induced carcinogenesis. It has been shown that synthetic chalcones and 3H-[1,2]-dithiole-3-thiones promote expression of genes involved in chemoprevention. Herein, the induction of phase II enzymes by designed Michael acceptor-dithiolethione hybrids was studied. Hybrids 5 and 7 displayed the induction of quinone-reductase and glutation-S-transferase in vitro in the same order on the wild-type mouse-hepatoma Hepa 1c1c7 and on the aryl-hydrocarbon-nuclear-translocator (Arnt)-defective mutant BPrc1 cells indicating that 7 displays the best chemopreventive potential.

  2. Synthesis of pyroglutamic acid derivatives via double michael reactions of alkynones.

    PubMed

    Scansetti, Myriam; Hu, Xiangping; McDermott, Benjamin P; Lam, Hon Wai

    2007-05-24

    In the presence of substoichiometric quantities of potassium tert-butoxide and an additional metal salt, amide-tethered diacids undergo double Michael reactions with alkynones to provide highly functionalized pyroglutamic acid derivatives. The metal salt was found to play an important role in improving the diastereoselectivities of the reactions.

  3. Broadening the Debate: Comments on Michael J. Feuer's "Moderating the Debate"

    ERIC Educational Resources Information Center

    Robertson, Emily

    2009-01-01

    In "Moderating the Debate: Rationality and the Promise of American Education", Michael Feuer argues that insights from cognitive science and the theory of bounded rationality can help us understand why educational policy makers overreach in seeking optimal solutions to educational problems. In this essay, Emily Robertson argues that cognitive…

  4. A celebration of mechanics: from nano to macro. The J. Michael T. Thompson Festschrift issue.

    PubMed

    Elishakoff, Isaac

    2013-06-28

    This Theme Issue is dedicated to the topic 'Mechanics: from nano to macro' and marks the 75th birthday of Dr J. Michael T. Thompson, Fellow of the Royal Society, whose current affiliations are as follows: (i) Honorary Fellow, Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge; (ii) Emeritus Professor of Nonlinear Dynamics, Department of Civil, Environmental and Geomatic Engineering, University College London; and (iii) Professor of Theoretical and Applied Dynamics (Distinguished Sixth Century Chair, part-time), University of Aberdeen. He also serves as Chairman of the Board of Directors at ES-Consult (consulting engineers) in Copenhagen, Denmark. The pertinent question that arises from the very start is: should we first salute Michael and then describe the Theme Issue, or vice versa? Indeed, according to Blaise Pascal (1623-1662), the last thing one discovers in composing a work is what to put first. I would like to take the liberty of deviating from the tradition of the Philosophical Transactions and start with the tribute to Michael; after all he is the prime cause of this Theme Issue.

  5. Acid-Activatable Michael-Type Fluorescent Probes for Thiols and for Labeling Lysosomes in Live Cells.

    PubMed

    Dai, Chun-Guang; Du, Xiao-Jiao; Song, Qin-Hua

    2015-12-18

    A Michael addition is usually taken as a base-catalyzed reaction. Most fluorescent probes have been designed to detect thiols in slightly alkaline solutions (pH 7-9). The sensing reactions of almost all Michael-type fluorescent probes for thiols are faster in a high pH solution than in a low pH solution. In this work, we synthesized a series of 7-substituted 2-(quinolin-2-ylmethylene)malonic acids (QMAs, substituents: NEt2, OH, H, Cl, or NO2) and their ethyl esters (QMEs) as Michael-type fluorescent probes for thiols. The sensing reactions of QMAs and QMEs occur in distinct pH ranges, pH < 7 for QMAs and pH > 7 for QMEs. On the basis of experimental and theoretic studies, we have clarified the distinct pH effects on the sensing reactivity between QMAs and QMEs and demonstrated that two QMAs (NEt2, OH) are highly sensitive and selective fluorescent probes for thiols in acidic solutions (pH < 7) and promising dyes that can label lysosomes in live cells.

  6. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

    PubMed

    Jackson, Paul A; Widen, John C; Harki, Daniel A; Brummond, Kay M

    2017-02-09

    Although Michael acceptors display a potent and broad spectrum of bioactivity, they have largely been ignored in drug discovery because of their presumed indiscriminate reactivity. As such, a dearth of information exists relevant to the thiol reactivity of natural products and their analogues possessing this moiety. In the midst of recently approved acrylamide-containing drugs, it is clear that a good understanding of the hetero-Michael addition reaction and the relative reactivities of biological thiols with Michael acceptors under physiological conditions is needed for the design and use of these compounds as biological tools and potential therapeutics. This Perspective provides information that will contribute to this understanding, such as kinetics of thiol addition reactions, bioactivities, as well as steric and electronic factors that influence the electrophilicity and reversibility of Michael acceptors. This Perspective is focused on α,β-unsaturated carbonyls given their preponderance in bioactive natural products.

  7. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions

    PubMed Central

    Jackson, Paul A.; Widen, John C.; Harki, Daniel A.; Brummond, Kay M.

    2017-01-01

    Although Michael acceptors display a potent and broad spectrum of bioactivity, they have largely been ignored in drug discovery because of their presumed indiscriminate reactivity. As such, a dearth of information exists relevant to the thiol reactivity of natural products and their analogs possessing this moiety. In the midst of recently approved acrylamide-containing drugs, it is clear that a good understanding of the hetero-Michael addition reaction and the relative reactivities of biological thiols with Michael acceptors under physiological conditions is needed for the design and use of these compounds as biological tools and potential therapeutics. This perspective provides information that will contribute to this understanding, such as kinetics of thiol addition reactions, bioactivities, as well as steric and electronic factors that influence the electrophilicity and reversibility of Michael acceptors. This perspective is focused on α,β-unsaturated carbonyls given their preponderance in bioactive natural products. PMID:27996267

  8. An Integral Part of the Frederick Community—Michael Dean | Poster

    Cancer.gov

    For more than 30 years, Michael Dean, Ph.D., has been an integral part of the NCI at Frederick community. In addition to studying several different aspects of genomics and cancer research, he has worked with the Werner H. Kirsten Student Intern Program and also volunteered his time with Mission of Mercy, a community-based organization providing free healthcare and free

  9. C. P. Snow's "The Two Cultures": Michael Polanyi's Response and Context

    ERIC Educational Resources Information Center

    Jacobs, Struan

    2011-01-01

    C. P. Snow's "The Two Cultures" controversially contrasted science and literature, suggesting that neither scientists nor literary intellectuals have much in common with, and seldom bother speaking to, the other. Responding to Snow, Michael Polanyi argued that specialization has made modern culture, not twofold but manifold. In his major work,…

  10. Atmospheric O2, CO2 and delta13C measurements from aircraft sampling over Griffin Forest, Perthshire, UK.

    PubMed

    Sturm, Patrick; Leuenberger, Markus; Moncrieff, John; Ramonet, Michel

    2005-01-01

    Regular vertical aircraft sampling has been performed in the lower troposphere above Griffin Forest, near Aberfeldy, Perthshire, UK (56 degrees 37'N, 3 degrees 47'W), between February 2003 and May 2004, for analysis of O2/N2, CO2 and delta13C of CO2. We sampled flasks between 800 and 3100 m above sea level. The peak-to-peak amplitude of the seasonal cycle of O2/N2 decreases from 171 per meg at 800 m to 113 per meg at 3100 m. Furthermore, the seasonal cycle is shifted from low to high altitudes with a lag of about 1 month. The same features are observed for CO2 with a decrease in the peak-to-peak amplitude of the seasonal cycle from 17.6 ppm at 800 m to 11.4 ppm at 3100 m. The vertical profiles show decreasing O2/N2 ratios in summer and increasing O2/N2 ratios in wintertime with increasing sampling height, due to surface exchange of oxygen with the land biosphere and the ocean. The O2:CO2 exchange ratios of the vertical profiles vary between -1.5 and -2.4 mol O2/mol CO2. Copyright (c) 2005 John Wiley & Sons, Ltd.

  11. Little Mosie from the Margaree: A Biography of Moses Michael Coady.

    ERIC Educational Resources Information Center

    Welton, Michael R.

    This book examines the life of the Reverend Moses Michael Coady (1890-1959), a Roman Catholic priest who led the Antigonish Movement. During the Antigonish Movement, residents of the small maritime town of Antigonish, Nova Scotia, worked to achieve a nonviolent alternative to communism and fascism and to effect the social and economic…

  12. Michael Duane after Risinghill: Rise and Fall of an Educational Celebrity

    ERIC Educational Resources Information Center

    Limond, David

    2005-01-01

    In this article an attempt is made to examine the continuing implications of the operation and closure of London's Risinghill school, a co-educational comprehensive extant from 1960 to 1965. It is suggested that Risinghill's controversial headteacher, Michael Duane (1915-1997), was an educational celebrity and folk hero amongst teachers and in…

  13. Astronaut C. Michael Foale is briefed on use of Sky Genie

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Astronaut C. Michael Foale, STS-63 mission specialist, is briefed on the use of Sky Genie device by Karin L. Porter. The device would aid in emergency egress operations aboard a troubled Space Shuttle. Porter, an employee of Rockwell International, helps train astronauts in egress procedures at JSC's Shuttle mockup and integration laboratory.

  14. Mission Specialist Michael Lopez-Alegria changes out film in camera

    NASA Image and Video Library

    1995-11-05

    STS073-335-009 (20 October-5 November 1995) --- Astronaut Michael E. Lopez-Alegria, STS-73 mission specialist, changes the film in a 35mm camera on the flight deck of the Earth-orbiting Space Shuttle Columbia. Alegria joined four other NASA astronauts and two guest researchers for almost 16-days of Earth-orbit research in support of the U.S. Microgravity Laboratory (USML-2) mission.

  15. A Critical Analysis of Michael Tippett's "A Child of Our Time"

    ERIC Educational Resources Information Center

    Vallee, Jean-Sebastien

    2009-01-01

    After more than ten years of thoughtful planning, Michael Tippett (1905-1998) summed up his musical, political, spiritual and philosophical beliefs in his first oratorio, "A Child of Our Time" (1941). Representing the emergence of a new level of confidence and musical maturity for Tippett, the oratorio has become the composer's most widely known…

  16. Gulliver's Travels: Michael Moore the Explorer in "Who to Invade Next"

    ERIC Educational Resources Information Center

    Beck, Bernard

    2016-01-01

    America is identified as a nation of immigrants. These immigrants are thought to be the source of its subcultures. It is also a nation of individual explorers and inventors. Their activities are also a source of diverse subcultures. Many notable movies have made heroes of such innovators in different fields of endeavor. Michael Moore's movie…

  17. Moral Education and Education in Altruism: Two Replies to Michael Hand

    ERIC Educational Resources Information Center

    White, John

    2016-01-01

    This article is a critical discussion of two recent papers by Michael Hand on moral education. The first is his "Towards a Theory of Moral Education", published in the "Journal of Philosophy of Education" in 2014 (Volume 48, Issue 4). The second is a chapter called "Beyond Moral Education?" in an edited book of new…

  18. An Interview with Michael Horn: Blending Education for High-Octane Motivation

    ERIC Educational Resources Information Center

    Patterson, Gregory A.

    2012-01-01

    Blended learning holds the potential of improving the way we educate students and of making them more motivated. Blended education--the melding of information technology based distance learning with school attendance--is perhaps the best way to educate students for 21st century skills, says Michael Horn in a "Kappan" interview. Horn points out…

  19. NASA Dryden test pilot Michael J. Adams

    NASA Image and Video Library

    1967-03-22

    Air Force test pilot Maj. Michael J. Adams stands beside X-15 ship number one. Adams was selected for the X-15 program in 1966 and made his first flight on Oct. 6, 1966. On Nov. 15, 1967, Adams made his seventh and final X-15 flight. The X-15 launched from the B-52, but during the ascent an electrical problem affected the X-15's control system. The aircraft crashed northwest of Cuddeback Lake, California, causing the death of Adams. He was posthumously awarded Air Force astronaut wings because his final flight exceeded 50 miles in altitude. Adams was the only pilot lost in the 199-flight X-15 program.

  20. KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (top) discusses the inner workings of Shuttle Atlantis in Orbiter Processing Facility Bay 1 with a United Space Alliance (USA) technician (bottom). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (top) discusses the inner workings of Shuttle Atlantis in Orbiter Processing Facility Bay 1 with a United Space Alliance (USA) technician (bottom). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  1. KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right) discusses a speed brake on Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (left). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right) discusses a speed brake on Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (left). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  2. KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) is given a tour of a solid rocket booster (SRB) retrieval ship by United Space Alliance (USA) employee Joe Chaput (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) is given a tour of a solid rocket booster (SRB) retrieval ship by United Space Alliance (USA) employee Joe Chaput (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  3. Q & A with Ed Tech Leaders: Interview with Michael W. Allen

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.

    2014-01-01

    Michael W. Allen, the Chairman and CEO of Allen Interactions, is an architect of interactive multimedia learning and is recognized for his many insights, inventions, and presentations. With over 50 years of experience in e-learning, both in academic and corporate settings, he is known for his role in creating Authorware and overseeing the work of…

  4. Irish Education for the 21st Century. Michael Enright Commemorative Project.

    ERIC Educational Resources Information Center

    Ward, Noel, Ed.; Dooney, Triona, Ed.

    The essays in this collection contribute to the ongoing discussion about the state of Irish education on the threshold of a new century. The various contributors examine issues that will be priorities for education planners in Ireland. These essays have been collected as a tribute to Irish educator and politician Michael Enright. The essays are:…

  5. The Benevolent Technocrat: Michael Dukakis' Strategy in the 1988 Presidential Debates.

    ERIC Educational Resources Information Center

    Herbeck, Dale A.

    Michael Dukakis lost the presidential campaign debates of 1988 (or at least failed to capitalize as much as he might have) because he understood the debates to be genuine debates. Consequently, Dukakis acted as a debater generating an image of himself as a "benevolent technocrat," which was an error. It must be pointed out that the…

  6. Michael F. Vaccaro Honors Attorney Fellowship Program in our Philadelphia (Region 3) Office

    EPA Pesticide Factsheets

    The Michael F. Vaccaro Honors Attorney Fellowship provides a unique opportunity to practice law in a major governmental environmental organization, and to receive extensive training in and exposure to environmental law and policy work in the public sector.

  7. An Integral Part of the Frederick Community—Michael Dean | Poster

    Cancer.gov

    For more than 30 years, Michael Dean, Ph.D., has been an integral part of the NCI at Frederick community. In addition to studying several different aspects of genomics and cancer research, he has worked with the Werner H. Kirsten Student Intern Program and also volunteered his time with Mission of Mercy, a community-based organization providing free healthcare and free prescription medications to the uninsured and under-insured.

  8. Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.

    PubMed

    Zheng, Suqing; Santosh Laxmi, Y R; David, Emilie; Dinkova-Kostova, Albena T; Shiavoni, Katherine H; Ren, Yanqing; Zheng, Ying; Trevino, Isaac; Bumeister, Ronald; Ojima, Iwao; Wigley, W Christian; Bliska, James B; Mierke, Dale F; Honda, Tadashi

    2012-05-24

    Novel monocyclic cyanoenones examined to date display unique features regarding chemical reactivity as Michael acceptors and biological potency. Remarkably, in some biological assays, the simple structure is more potent than pentacyclic triterpenoids (e.g., CDDO and bardoxolone methyl) and tricycles (e.g., TBE-31). Among monocyclic cyanoenones, 1 is a highly reactive Michael acceptor with thiol nucleophiles. Furthermore, an important feature of 1 is that its Michael addition is reversible. For the inhibition of NO production, 1 shows the highest potency. Notably, its potency is about three times higher than CDDO, whose methyl ester (bardoxolone methyl) is presently in phase III clinical trials. For the induction of NQO1, 1 also demonstrated the highest potency. These results suggest that the reactivity of these Michael acceptors is closely related to their biological potency. Interestingly, in LPS-stimulated macrophages, 1 causes apoptosis and inhibits secretion of TNF-α and IL-1β with potencies that are higher than those of bardoxolone methyl and TBE-31.

  9. Space Shuttle Program

    NASA Image and Video Library

    2012-09-12

    Ronnie Rigney (r), chief of the Propulsion Test Office in the Project Directorate at Stennis Space Center, stands with agency colleagues to receive the prestigious American Institute of Aeronautics and Astronautics George M. Low Space Transportation Award on Sept. 12. Rigney accepted the award on behalf of the NASA and contractor team at Stennis for their support of the Space Shuttle Program that ended last summer. From 1975 to 2009, Stennis Space Center tested every main engine used to power 135 space shuttle missions. Stennis continued to provide flight support services through the end of the Space Shuttle Program in July 2011. The center also supported transition and retirement of shuttle hardware and assets through September 2012. The 2012 award was presented to the space shuttle team 'for excellence in the conception, development, test, operation and retirement of the world's first and only reusable space transportation system.' Joining Rigney for the award ceremony at the 2012 AIAA Conference in Pasadena, Calif., were: (l to r) Allison Zuniga, NASA Headquarters; Michael Griffin, former NASA administrator; Don Noah, Johnson Space Center in Houston; Steve Cash, Marshall Space Flight Center in Huntsville, Ala.; and Pete Nickolenko, Kennedy Space Center in Florida.

  10. Theory and practice in action: the contributions of Michael Perkins to clinical linguistics.

    PubMed

    Damico, Jack S; Lynch, Karen E

    2013-01-01

    This article reviews the scholarly contributions of Michael R. Perkins in the discipline of clinical linguistics and provides some indication of the reasons that he has been so successful. Three primary attributes were described through an analysis of his publications.

  11. From Gouldner to Gramsci: The Making of Michael Apple's "Ideology and Curriculum"

    ERIC Educational Resources Information Center

    Gottesman, Isaac

    2012-01-01

    Michael Apple's "Ideology and Curriculum", published in 1979, helped initiate a broad turn in the field of education in the United States to Marxist thought as a lens through which to analyze the relationship between school and society. This classic text continues to inform scholarship in the field. While "Ideology" has…

  12. NASA Administrator, U.S. Secretary of State watch STS-88 launch

    NASA Technical Reports Server (NTRS)

    1998-01-01

    At the Banana Creek Viewing Site, NASA Administrator Daniel Goldin (left), U.S. Secretary of State Madeleine Albright (center) and astronaut Michael Lopez-Alegria watch the launch of STS-88 from Launch Pad 39A at 3:35:34 a.m. EST. STS-88 is the first U.S. mission dedicated to the assembly of the International Space Station (ISS). Lopez-Alegria is part of the STS-92 crew that is assigned to the fourth ISS assembly flight scheduled for launch on Oct. 28, 1999, aboard Discovery.

  13. NASA Administrator Dan Goldin and Bob Sieck on SLF

    NASA Technical Reports Server (NTRS)

    1997-01-01

    NASA Administrator Daniel S. Goldin (center) and KSC Director of Shuttle Operations Robert B. Sieck (right) discuss the successful conclusion of the STS-81 mission with Mission Commander Michael A. Baker (left). They are underneath the Space Shuttle orbiter Atlantis after the space plane landed on Runway 33 at the KSC Shuttle Landing Facility at 9:22:44 a.m. EST Jan. 22 to conclude the fifth Shuttle-Mir docking mission. At main gear touchdown, the STS-81 mission duration was 10 days, 4 hours, 55 minutes. This was the 34th KSC landing in Shuttle history.

  14. Highlighting High Performance: Michael E. Capuano Early Childhood Center; Somerville, Massachusetts

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    2006-03-01

    This brochure describes the key high-performance building features of the Michael E. Capuano Early Childhood Center. The brochure was paid for by the Massachusetts Technology Collaborative as part of their Green Schools Initiative. High-performance features described are daylighting and energy-efficient lighting, indoor air quality, solar and wind energy, building envelope, heating and cooling systems, water conservation, and acoustics. Energy cost savings are also discussed.

  15. A tribute to Michael R. Raupach for contributions to aeolian fluid dynamics

    USDA-ARS?s Scientific Manuscript database

    Since the early work of Bagnold in the 1940s, aeolian research has grown to become a major integral part of earth-system studies. Many individuals have contributed to this development, and Dr. Michael R. Raupach (MR2, 1950 – 2015) was one of the most outstanding. MR2 worked for about a decade (1985 ...

  16. Schools as "Poetry-Friendly Places": Michael Rosen on Poetry in the Curriculum

    ERIC Educational Resources Information Center

    Xerri, Daniel

    2014-01-01

    This article explores the views of children's poet Michael Rosen in relation to poetry in education. It is based on an interview in which Rosen not only discusses the significance of encouraging young people to engage with poetry at school but also analyzes a number of threats to poetry's place in the English curriculum. This article identifies…

  17. Michael Maier--nine newly discovered letters.

    PubMed

    Lenke, Nils; Roudet, Nicolas; Tilton, Hereward

    2014-02-01

    The authors provide a transcription, translation, and evaluation of nine newly discovered letters from the alchemist Michael Maier (1568-1622) to Gebhardt Johann von Alvensleben (1576-1631), a noble landholder in the vicinity of Magdeburg. Stemming from the final year of his life, this correspondence casts new light on Maier's biography, detailing his efforts to secure patronage amid the financial crisis of the early Thirty Years' War. While his ill-fated quest to perfect potable gold continued to form the central focus of his patronage suits, Maier also offered his services in several arts that he had condemned in his printed works, namely astrology and "supernatural" magic. Remarks concerning his previously unknown acquaintance with Heinrich Khunrath call for a re-evaluation of Maier's negotiation of the discursive boundaries between Lutheran orthodoxy and Paracelsianism. The letters also reveal Maier's substantial contribution to a work previously ascribed solely to the English alchemist Francis Anthony.

  18. STS-69 MS Michael L. Gernhardt greets his mother at SLF

    NASA Technical Reports Server (NTRS)

    1995-01-01

    STS-69 Mission Specialist Michael L. Gernhardt (right) gets a chance to say hi to his mother, Suzanne Winters, and her husband Doug, after the STS-69 flight crew arrived at KSC's Shuttle Landing Facility. The five astronauts assigned to the mission are looking forward to a liftoff aboard the Space Shuttle Endeavour during a two and a half hour window opening at 11:09 a.m. EDT, Sept. 7.

  19. The Politics of Education Revisited: Anthony Crosland and Michael Gove in Historical Perspective

    ERIC Educational Resources Information Center

    Finn, Mike

    2015-01-01

    This article traces continuity and change in the governance of British education through the comparison of two ministers, Anthony Crosland and Michael Gove. Taking Maurice Kogan's seminal "The Politics of Education" as the point of departure, the article highlights the role of political ideology in large-scale educational change, taking…

  20. Neuroscientific Investigator of High Mathematical Ability: An Interview with Michael W. O'Boyle

    ERIC Educational Resources Information Center

    Kalbfleisch, M. Layne

    2008-01-01

    This article presents an interview with Michael W. O'Boyle, a neuroscientific investigator of high mathematical ability. O'Boyle is a professor in the Department of Human Development and Family Studies, Texas Tech University, and Adjunct Professor of Pharmacology and Neuroscience, School of Medicine, Texas Tech University Health Sciences Center.…

  1. Toward a Global Vision of Gifted Education: An Interview with Michael S. Matthews

    ERIC Educational Resources Information Center

    Henshon, Suzanna E.

    2017-01-01

    Dr. Michael S. Matthews is professor and director of the Academically & Intellectually Gifted graduate programs at the University of North Carolina at Charlotte. He is incoming Coeditor of the "Gifted Child Quarterly" and a member of the Board of Directors of the National Association for Gifted Children. Dr. Matthews also currently…

  2. The Journey Is the Film Is the Journey: Michael Winterbottom's "In This World"

    ERIC Educational Resources Information Center

    Farrier, David

    2008-01-01

    This essay examines Michael Winterbottom's 2002 film "In This World," which follows the journey of two Afghan migrants from Peshawar to London. Winterbottom's preparation involved travelling from London to Peshawar and then in reverse overland as far as Istanbul; he then returned to Peshawar and filmed the same journey using two…

  3. KENNEDY SPACE CENTER, FLA. -- A United Space Alliance (USA) technician (center) discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- A United Space Alliance (USA) technician (center) discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  4. Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.

    PubMed

    Maucher, Isabelle V; Rühl, Michael; Kretschmer, Simon B M; Hofmann, Bettina; Kühn, Benjamin; Fettel, Jasmin; Vogel, Anja; Flügel, Karsten T; Manolikakes, Georg; Hellmuth, Nadine; Häfner, Ann-Kathrin; Golghalyani, Vahid; Ball, Ann-Katrin; Piesche, Matthias; Matrone, Carmela; Geisslinger, Gerd; Parnham, Michael J; Karas, Michael; Steinhilber, Dieter; Roos, Jessica; Maier, Thorsten J

    2017-02-01

    Recently, we published that nitro-fatty acids (NFA) are potent electrophilic molecules which inhibit 5-lipoxygenase (5-LO) by interacting catalytically with cysteine residues next to a substrate entry channel. The electrophilicity is derived from an intramolecular Michael acceptor moiety consisting of an electron-withdrawing group in close proximity to a double bond. The potential of the Michael acceptor moiety to interact with functionally relevant cysteines of proteins potentially renders them effective and sustained enzyme activity modulators. We screened a large library of naturally derived and synthetic electrophilic compounds to investigate whether other types of Michael acceptor containing drugs suppress 5-LO enzyme activity. The activity was measured by assessing the effect on the 5-LO product formation of intact human polymorphonuclear leukocytes. We demonstrated that a number of structurally different compounds were suppressive in the activity assays and showed that Michael acceptors of the quinone and nitro-alkene group produced the strongest inhibition of 5-LO product formation. Reactivity with the catalytically relevant cysteines 416 and 418 was confirmed using mutated recombinant 5-LO and mass spectrometric analysis (MALDI-MS). In the present study, we show for the first time that a number of well-recognized naturally occurring or synthetic anti-inflammatory compounds carrying a Michael acceptor, such as thymoquinone (TQ), the paracetamol metabolite NAPQI, the 5-LO inhibitor AA-861, and bardoxolone methyl (also known as RTA 402 or CDDO-methyl ester) are direct covalent 5-LO enzyme inhibitors that target the catalytically relevant cysteines 416 and 418. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. VEHICLE AND MODE OF ADMINISTRATION EFFECTS ON THE INDUCTION OF ABERRANT CRYPT FOCI IN THE COLONS OF MALE F344/N RATS EXPOSED TO BROMODICHLOROMETHANE

    EPA Science Inventory

    Vehicle and Mode of Administration Effects on the Induction of Aberrant Crypt Foci in the Colons of Male F344/N Rats Exposed to Bromodichloromethane.

    David R. Geter, Michael H. George, Tanya M. Moore, Steve Kilburn, Gloria Huggins-Clark, and Anthony B. DeAngelo. Submited ...

  6. What Work Do the Concepts of "Language" and "Literature" Do for Michael Rosenak?

    ERIC Educational Resources Information Center

    Levisohn, Jon A.

    2014-01-01

    Michael Rosenak uses the twin metaphors of "language" and "literature," borrowed from Oakeshott and Peters, to argue that the goal of education is initiation into a language. This goal transcends the study of literature in that language. It includes, as well, the development of the capacity both to critique literature and to…

  7. Subjectivity and Cultural Adjustment in Mathematics Education: A Response to Wolff-Michael Roth

    ERIC Educational Resources Information Center

    Brown, Tony

    2012-01-01

    In this volume, Wolff-Michael Roth provides a critical but partial reading of Tony Brown's book "Mathematics Education and Subjectivity". The reading contrasts Brown's approach with Roth's own conception of subjectivity as derived from the work of Vygotsky, in which Roth aims to "reunite" psychology and sociology. Brown's book, however, focuses on…

  8. Development of a Fragment-Based in Silico Profiler for Michael Addition Thiol Reactivity.

    PubMed

    Ebbrell, David J; Madden, Judith C; Cronin, Mark T D; Schultz, Terry W; Enoch, Steven J

    2016-06-20

    The Adverse Outcome Pathway (AOP) paradigm details the existing knowledge that links the initial interaction between a chemical and a biological system, termed the molecular initiating event (MIE), through a series of intermediate events, to an adverse effect. An important example of a well-defined MIE is the formation of a covalent bond between a biological nucleophile and an electrophilic compound. This particular MIE has been associated with various toxicological end points such as acute aquatic toxicity, skin sensitization, and respiratory sensitization. This study has investigated the calculated parameters that are required to predict the rate of chemical bond formation (reactivity) of a dataset of Michael acceptors. Reactivity of these compounds toward glutathione was predicted using a combination of a calculated activation energy value (Eact, calculated using density functional theory (DFT) calculation at the B3YLP/6-31G+(d) level of theory, and solvent-accessible surface area values (SAS) at the α carbon. To further develop the method, a fragment-based algorithm was developed enabling the reactivity to be predicted for Michael acceptors without the need to perform the time-consuming DFT calculations. Results showed the developed fragment method was successful in predicting the reactivity of the Michael acceptors excluding two sets of chemicals: volatile esters with an extended substituent at the β-carbon and chemicals containing a conjugated benzene ring as part of the polarizing group. Additionally the study also demonstrated the ease with which the approach can be extended to other chemical classes by the calculation of additional fragments and their associated Eact and SAS values. The resulting method is likely to be of use in regulatory toxicology tools where an understanding of covalent bond formation as a potential MIE is important within the AOP paradigm.

  9. A Response to Michael W. Apple's "Theory, Research, and the Critical Scholar/Activist"

    ERIC Educational Resources Information Center

    Leonardo, Zeus

    2010-01-01

    Michael Apple's prescient review of Anyon et al.'s "Theory and Educational Research" reminds the educational community of the importance of purpose. In his own work, he has been consistent in--actually, insistent on--emphasizing the struggle over political projects. This is not an issue concerning only the Left as the scapegoat for the disparaging…

  10. N719 dye-sensitized organophotocatalysis: enantioselective tandem Michael addition/oxyamination of aldehydes.

    PubMed

    Yoon, Hyo-Sang; Ho, Xuan-Huong; Jang, Jiyeon; Lee, Hwa-Jung; Kim, Seung-Joo; Jang, Hye-Young

    2012-07-06

    A remarkably efficient photosensitizer, N719 dye, was used in asymmetric tandem Michael addition/oxyamination of aldehydes, rendering α,β-substituted aldehydes in good yields with excellent levels of enantioselectivity and diastereoselectivity. This is the first report of a multiorganocatalytic reaction involving iminium catalysis and photoinduced singly occupied molecular orbital (SOMO) catalysis. This reaction is expected to expand the scope of tandem organocatalytic reactions.

  11. [The problem of evil in families--the filmmaker Michael Haneke].

    PubMed

    Skårderud, Finn

    2010-09-23

    With the beautiful and dark film "The white ribbon", from 2009, the Austrian film director Michael Haneke consolidated his status as an international success. A central theme in his films is evilness and its roots. But just as important is his ambition to develop films where evil is not only portrayed, but where spectators are challenged to relate to their own ethical standards and their role as spectators. Haneke is a highly original filmmaker with his consistent search for a film aesthetic that stimulates ethical self-reflection and mentalizing. He partly succeeds in this quest.

  12. Training and Mastery of Techniques in Wittgenstein's Later Philosophy: A Response to Michael Luntley

    ERIC Educational Resources Information Center

    Stickney, Jeff

    2008-01-01

    Responding to Michael Luntley's article, "Learning, Empowerment and Judgement," the author shows he cannot successfully make the following three moves: (1) dissolve the analytic distinction between learning by training and learning by reasoning, while advocating the latter; (2) diminish the role of training in Wittgenstein's philosophy, nor…

  13. The Data on Children's Media Use: An Interview with Michael Robb

    ERIC Educational Resources Information Center

    Heller, Rafael

    2018-01-01

    Since 2003, nonprofit organization Common Sense Media has studied the ways in which kids are growing up in the digital age. In this interview, research director Michael Robb shares recent findings about the media habits of young children, tweens, and teens. While the news coverage of these issues tends to be hyperbolic and alarming, Robb explains,…

  14. The Educational Philosophies of Mordecai Kaplan and Michael Rosenak: Surprising Similarities and Illuminating Differences

    ERIC Educational Resources Information Center

    Schein, Jeffrey; Caplan, Eric

    2014-01-01

    The thoughts of Mordecai Kaplan and Michael Rosenak present surprising commonalities as well as illuminating differences. Similarities include the perception that Judaism and Jewish education are in crisis, the belief that Jewish peoplehood must include commitment to meaningful content, the need for teachers to teach from a position of…

  15. Evaluation of GPS Coverage for the X-33 Michael-6 Trajectory

    NASA Technical Reports Server (NTRS)

    Lundberg, John B.

    1998-01-01

    The onboard navigational system for the X-33 test flights will be based on the use of measurements collected from the Embedded Global Positioning System (GPS)/INS system. Some of the factors which will affect the quality of the GPS contribution to the navigational solution will be the number of pseudorange measurements collected at any instant in time, the distribution of the GPS satellites within the field of view, and the inherent noise level of the GPS receiver. The distribution of GPS satellites within the field of view of the receiver's antenna will depend on the receiver's position, the time of day, pointing direction of the antenna, and the effective cone angle of the antenna. The number of pseudorange measurements collected will depend upon these factors as well as the time required to lock onto a GPS satellite signal once the GPS satellite comes into the field of view of the antenna and the number of available receiver channels. The objective of this study is to evaluate the GPS coverage resulting from the proposed antenna pointing directions, the proposed antenna cone angles, and the effects due to the time of day for the X-33 Michael-6 trajectory from launch at Edwards AFB, California, to the start of the Terminal Area Energy Management (TAEM) phase on approach to Michael AAF, Utah.

  16. Enantioselective Michael Addition of Pyrroles with Nitroalkenes in Aqueous Media Catalyzed by a Water-soluble Catalyst.

    PubMed

    Gui, Yang; Li, Yanan; Sun, Jianan; Zha, Zhenggen; Wang, Zhiyong

    2018-06-11

    A new water-soluble catalytic system were developed and therefor used in an enantioselective Michael addition of pyrroles with nitroalkenes in water to afford the nitroethylpyrrole derivatives with both excellent yields and ee values.

  17. "Raising Standards" or Reducing Aspirations and Opportunities Still Further? Michael Gove and Examination Reforms

    ERIC Educational Resources Information Center

    Allen, Martin

    2013-01-01

    Well before the examinations grade crisis of 2012, Michael Gove had set out clear intentions for reforming public examinations. Though he claimed to be improving examinations and assessment by replicating practices that took place in high-performing countries and thus improving the ability of the UK economy to "compete", this…

  18. Wolff-Michael Roth's passibility: at the limits of the constructivist metaphor: a book review

    NASA Astrophysics Data System (ADS)

    Brendel, Michelle

    2014-12-01

    Wolff-Michael Roth deconstructs the preeminent role conceded to constructivism in Science Education and demonstrates how we learn and know through pain, suffering, love or passion. This review explores his book "Passibility: At the Limits of the Constructivist Metaphor" through the eyes of an outsider to the world of science education.

  19. Michael's Inform Test of Student Ability (M.I.T.O.S.A.). Tester's Manual.

    ERIC Educational Resources Information Center

    Grafius, Thomas M.

    Michael's Informal Test of Student Ability (MITOSA) is a diagnostic evaluative tool for adult students designed to test nine skills abilities in adult students functioning below a tenth grade level. The nine test sections are approximate reading level, understanding of basic math concepts and symbols, general thinking/reasoning ability, eye-hand…

  20. Superelastic and pH-Responsive Degradable Dendrimer Cryogels Prepared by Cryo-aza-Michael Addition Reaction.

    PubMed

    Wang, Juan; Yang, Hu

    2018-05-08

    Dendrimers exhibit super atomistic features by virtue of their well-defined discrete quantized nanoscale structures. Here, we show that hyperbranched amine-terminated polyamidoamine (PAMAM) dendrimer G4.0 reacts with linear polyethylene glycol (PEG) diacrylate (575 g/mol) via the aza-Michael addition reaction at a subzero temperature (-20 °C), namely cryo-aza-Michael addition, to form a macroporous superelastic network, i.e., dendrimer cryogel. Dendrimer cryogels exhibit biologically relevant Young's modulus, high compression elasticity and super resilience at ambient temperature. Furthermore, the dendrimer cryogels exhibit excellent rebound performance and do not show significant stress relaxation under cyclic deformation over a wide temperature range (-80 to 100 °C). The obtained dendrimer cryogels are stable at acidic pH but degrade quickly at physiological pH through self-triggered degradation. Taken together, dendrimer cryogels represent a new class of scaffolds with properties suitable for biomedical applications.

  1. New eco-friendly animal bone meal catalysts for preparation of chalcones and aza-Michael adducts

    PubMed Central

    2012-01-01

    Abstract Two efficient reactions were successfully carried out using Animal Bone Meal (ABM) and potassium fluoride or sodium nitrate doped ABMs as new heterogeneous catalysts under very mild conditions. After preparation and characterization of the catalysts, we first report their use in a simple and convenient synthesis of various chalcones by Claisen–Schmidt condensation and then in an aza-Michael addition involving several synthesized chalcones with aromatic amines. All the reactions were carried out at room temperature in methanol; the chalcone synthesis was also achieved in water environment under microwave irradiation. Doping ABM enhances the rate and yield at each reaction. Catalytic activities are discussed and the ability to re-use the ABM is demonstrated. Results For Claisen–Schmidt the use of ABM alone, yields never exceeded 17%. In each entry, KF/ABM and NaNO3/ABM (79-97%) gave higher yields than using ABM alone under thermic condition. Also the reaction proceeded under microwave irradiation in good yields (72-94% for KF/ABM and 81-97% for NaNO3/ABM) and high purity. For aza-Michael addition the use of ABM doped with KF or NaNO3 increased the catalytic activity remarkably. The very high yields could be noted (84-95% for KF/ABM and 81-94% for NaNO3/ABM). Conclusion The present method is an efficient and selective procedure for the synthesis of chalcones an aza-Michael adducts. The ABM and doped ABMs are a new, inexpensive and attractive solid supports which can contribute to the development of catalytic processes and reduced environmental problems. PMID:22721409

  2. KSC-06pd1423

    NASA Image and Video Library

    2006-07-04

    KENNEDY SPACE CENTER, FLA. - In Firing Room 4 of the Launch Control Center, NASA Administrator Mike Griffin congratulates the launch team on the successful launch of Space Shuttle Discovery on mission STS-121. The launch was the first ever to take place on Independence Day. Liftoff was on-time at 2:38 p.m. EDT. Others next to Griffin are (left to right) David R. Mould, assistant administrator for NASA Public Affairs ; Lisa Malone, director of External Relations at Kennedy; Bruce Buckingham, news chief at the NASA News Center at Kennedy; and Mike Leinbach, Shuttle Program director. During the 12-day mission, the STS-121 crew of seven will test new equipment and procedures to improve shuttle safety, as well as deliver supplies and make repairs to the International Space Station. Landing is scheduled for July 16 or 17 at Kennedy's Shuttle Landing Facility. Photo credit: NASA/Kim Shiflett

  3. STS-109 Crew Interviews: Michael J. Massimino

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-109 Mission Specialist Michael J. Massimino is seen during a prelaunch interview. He answers questions about his inspiration to become an astronaut, his career path, and his most memorable experiences. He gives details on the mission's goals and objectives, which focus on the refurbishing of the Hubble Space Telescope, and his role in the mission. He explains the plans for the rendezvous of the Columbia Orbiter with the Hubble Space Telescope. He provides details and timelines for each of the planned Extravehicular Activities (EVAs), which include replacing the solar arrays, changing the Power Control Unit, installing the Advanced Camera for Surveys (ACS), and installing a new Cryocooler for the Near Infrared Camera and Multi-Object Spectrometer (NICMOS). He also describes the break-out plan in place for these spacewalks. The interview ends with Massimino explaining the details of a late addition to the mission's tasks, which is to replace a reaction wheel on the Hubble Space Telescope.

  4. The extraordinary impact of Michael Faraday on chemistry and related subjects.

    PubMed

    Thomas, John Meurig

    2017-08-25

    Biographers of Michael Faraday, as well as many dictionaries of science, often describe him as a physicist, which he certainly was. But he was also an astonishingly effective chemist: in fact, he was the Fullerian Professor of Chemistry (at the Royal Institution, RI) from 1834 until the time of his death in August, 1867. To mark the sesquicentenary of his passing, this editorial, by one of his distant successors as Director and Fullerian Professor at the RI, focuses on Faraday's output and influence as a scientist.

  5. KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Manager of the Thermal Protection System (TPS) Facility Martin Wilson (right) briefs NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) on the properties of a thermal blanket used in the Shuttle's TPS. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Manager of the Thermal Protection System (TPS) Facility Martin Wilson (right) briefs NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) on the properties of a thermal blanket used in the Shuttle's TPS. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  6. KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) discusses some of the working parts inside the nose of Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (back to camera). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) discusses some of the working parts inside the nose of Shuttle Discovery in Orbiter Processing Facility Bay 3 with a United Space Alliance (USA) technician (back to camera). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  7. KENNEDY SPACE CENTER, FLA. -- From front row left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons are trained on the proper use of the Emergency Life Support Apparatus (ELSA). NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From front row left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons are trained on the proper use of the Emergency Life Support Apparatus (ELSA). NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  8. Gender Relations and Sexual Harassment in the Workplace: Michael Crichton's "Disclosure" as a Teaching Tool.

    ERIC Educational Resources Information Center

    Comer, Debra R.; Cooper, Elizabeth A.

    1998-01-01

    Describes how to use Michael Crichton's novel "Disclosure" and the film based on it for class discussions of such issues as what constitutes sexual harassment, harassment of men, relationship between sexual harassment and power, organizational responses to harassment, and gender differences in career advancement tactics. (SK)

  9. Double hetero-Michael addition of N-substituted hydroxylamines to quinone monoketals: synthesis of bridged isoxazolidines.

    PubMed

    Yin, Zhiwei; Zhang, Jinzhu; Wu, Jing; Liu, Che; Sioson, Kate; Devany, Matthew; Hu, Chunhua; Zheng, Shengping

    2013-07-19

    A general synthesis of bridged isoxazolidines from a double hetero-Michael addition of N-substituted hydroxylamines to quinone monoketals has been developed. The different addition order of N-benzylhydroxylamine and N-Boc hydroxylamine is also discussed. Moreover, the various functionalities in the isoxazolidine products allow facile derivatization.

  10. Dr Michaels® product family (also branded as Soratinex®) versus Methylprednisolone aceponate - a comparative study of the effectiveness for the treatment of plaque psoriasis.

    PubMed

    Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Tirant, M; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    As one of the most common dermatologic chronic-recurrent disease, variable therapeutic options are available today for management of psoriasis. Although topical high potency corticosteroids, alone or in association with salicylic acid or vitamin D analogues, are still considered the best treatment, they do not seem to possess the capability for a long-term control of the disease or prevent recurrences, as their side effects are major contraindications for continuative use. The aim of this study was to investigate whether Dr. Michaels® product family is comparable to methylprednisolone aceponate (MPA) as a viable alternative treatment option for the treatment and management of stable chronic plaque psoriasis. Thirty adults (13 male, 17 female, mean age 40 years) with mild to severe stable chronic plaque psoriasis, were included in the study. Patients were advised to treat the lesions of the two sides of their body (left and right) with two different unknown modalities for 8 weeks; the pack of Dr. Michaels® products on the left side (consisting of a cleansing gel, an ointment and a skin conditioner) and a placebo pack on the right side, consisting of a cleansing gel, methylprednisolone ointment and a placebo conditioner. Assessment was done using the Psoriasis Activity Severity Index (PASI) scores before treatment and after 2, 4, 6 and 8 weeks. The results achieved with the Dr. Michaels® (Soratinex®) product family for the treatment of chronic plaque psoriasis were better than the results achieved with methylprednisolone aceponate (MPA), even though quicker resolution was achieved with the steroid with 45% of patients achieving resolution within 8-10 days in comparison to 5-6 weeks in the Dr. Michaels® (Soratinex®) group. Before therapy, the mean PASI score of the LHS in Dr. Michaels® (Soratinex®) group was 13.8±4.1 SD and 14.2±4.2 SD in the RHS methylprednisolone aceponate (MPA) group. After 8 weeks of treatment 62% of the Dr. Michaels® (Soratinex

  11. STS-84 Mission Specialist C. Michael Foale in white room

    NASA Technical Reports Server (NTRS)

    1997-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-84 Mission Specialist C. Michael Foale prepares to enter the Space Shuttle Atlantis at Launch Pad 39A with help from white room closeout crew members. The fourth Shuttle mission of 1997 will be the sixth docking of the Space Shuttle with the Russian Space Station Mir. The commander is Charles J. Precourt. The pilot is Eileen Marie Collins. The five mission specialists are C. Michael Foale, Carlos I. Noriega, Edward Tsang Lu, Jean-Francois Clervoy of the European Space Agency and Elena V. Kondakova of the Russian Space Agency. The planned nine-day mission will include the exchange of Foale for U.S. astronaut and Mir 23 crew member Jerry M. Linenger, who has been on Mir since Jan. 15. Linenger transferred to Mir during the last docking mission, STS-81; he will return to Earth on Atlantis. Foale is slated to remain on Mir for about four months until he is replaced in September by STS-86 Mission Specialist Wendy B. Lawrence. During the five days Atlantis is scheduled to be docked with the Mir, the STS-84 crew and the Mir 23 crew, including two Russian cosmonauts, Commander Vasily Tsibliev and Flight Engineer Alexander Lazutkin, will participate in joint experiments. The STS-84 mission also will involve the transfer of more than 7,300 pounds of water, logistics and science equipment to and from the Mir. Atlantis is carrying a nearly 300-pound oxygen generator to replace one of two Mir units which have experienced malfunctions. The oxygen it generates is used for breathing by the Mir crew.

  12. Thiol-ene Michael-type formation of gelatin/poly(ethylene glycol) biomatrices for three-dimensional mesenchymal stromal/stem cell administration to cutaneous wounds

    PubMed Central

    Xu, Kedi; Cantu, David Antonio; Fu, Yao; Kim, Jaehyup; Zheng, Xiaoxiang; Hematti, Peiman; Kao, W. John

    2013-01-01

    Mesenchymal stromal/stem cells (MSCs) are considered promising cellular therapeutics in the fields of tissue engineering and regenerative medicine. MSCs secrete high concentrations of immunomodulatory cytokines and growth factors, which exert paracrine effects on infiltrating immune and resident cells of the wound microenvironment that could favorably promote healing after acute injury. However, better spatial delivery and improved retention at the site of injury are two factors that could improve the clinical application of MSCs. In this study, we utilized thiol-ene Michael-type addition for rapid encapsulation of MSCs within a gelatin/poly(ethylene glycol) biomatrix; this biomatrix was also applied as a provisional dressing to full-thickness wounds in Sprague-Dawley rats. The three-way interaction of MSCs, gelatin/poly(ethylene glycol) biomatrices, and host immune cells and adjacent resident cells of the wound microenvironment favorably modulated wound progression and host response. In this model we observed attenuated immune cell infiltration, lack of foreign giant cell (FBGC) formation, accelerated wound closure and re-epithelialization, as well as enhanced neovascularization and granulation tissue formation by 7 days. The MSC-entrapped gelatin/poly(ethylene glycol) biomatrix localized the presentation of MSCs adjacent to the wound microenvironment and thus, mediated early resolution of inflammatory events and facilitated proliferative phases in wound healing. PMID:23811217

  13. STS-121: Discovery Post Landing Press Conference

    NASA Technical Reports Server (NTRS)

    2006-01-01

    On July 17, 2006 Dean Acosta (NASA Press Secretary), Mike Griffin (Administrator), Bill Gerstenmaier (Associate Administrator of Space Operations), and Mike Leinbach (NASA Launch Director) expressed how proud they were to be a part of the STS-121/ Discovery team. They also explained how flawlessly the mission performed and how it was the best mission ever flown. They proceeded to answer numerous questions from the press.

  14. Education, Philosophy and Politics: The Selected Works of Michael A. Peters. World Library of Educationalists

    ERIC Educational Resources Information Center

    Peters, Michael A.

    2012-01-01

    In the World Library of Educationalists series, international experts themselves compile career-long collections of what they judge to be their finest pieces--extracts from books, key articles, salient research findings, major theoretical and/practical contributions--so the world can read them in a single manageable volume. Michael A. Peters has…

  15. Michael Tuomey's 1848 geological survey of South Carolina

    USGS Publications Warehouse

    Nystrom, P.G.

    1999-01-01

    One hundred and fifty years ago, Michael Tuomey completed his 'Report on the Geology of South Carolina,' the result of four years of arduous labor. The report is the first detailed and comprehensive geological description of the entire state, and it includes a geological map that shows the distribution of Coastal Plain and Piedmont-Blue Ridge units. In the sesquicentennial of Tuomey's survey, it is fitting that we recognize his important early contribution to the geology of South Carolina and the southeast. Tuomey's report is a 293-page volume with a 48-page appendix and an index. Although he gave a complete depiction of Coastal Plain geology and delineated Cretaceous, Lower Eocene, Eocene, Miocene, Post-Pliocene, and alluvial units on his map, the emphasis herein is on his mapping of the Piedmont and Blue Ridge. The metamorphic units he delineated are clay slate, mica slate, talcose slate, hornblende slate, gneiss, and lime rock. Gneiss is the most extensive unit on the map. His map shows many elements of the geologic framework we recognize today. The distribution of his clay slate unit corresponds closely with the Carolina slate and Bel Air belts as we know them now. The gneiss between the two clay slate areas matches the Kiokee belt. Areas of mica slate approximate the northern part of the Kings Mountain belt and the Chauga belt. He also recognized that his talcose slate unit was associated with gold deposits. Granitic and basaltic intrusive rocks are also delineated on the map. It shows the Newberry, Columbia, and Liberty Hill granites we recognize today. Basaltic intrusives outlined include the Bush River of western Newberry County, Dutchmans Creek, Big Wateree Creek, and Ogden gabbros. He described the regional extent of diabase dikes as occuring from Virginia to Alabama, noted their preferred direction and diagrammed their near-vertical orientation. He also referred to the distinctive soil and topography that develops on the large gabbros. Michael Tuomey

  16. Asymmetric synthesis of α-amino acids via homologation of Ni(II) complexes of glycine Schiff bases. Part 3: Michael addition reactions and miscellaneous transformations.

    PubMed

    Aceña, José Luis; Sorochinsky, Alexander E; Soloshonok, Vadim

    2014-09-01

    The major goal of this review is a critical discussion of the literature data on asymmetric synthesis of α-amino acids via Michael addition reactions involving Ni(II)-complexes of amino acids. The material covered is divided into two conceptually different groups dealing with applications of: (a) Ni(II)-complexes of glycine as C-nucleophiles and (b) Ni(II)-complexes of dehydroalanine as Michael acceptors. The first group is significantly larger and consequently subdivided into four chapters based on the source of stereocontrolling element. Thus, a chiral auxiliary can be used as a part of nucleophilic glycine Ni(II) complex, Michael acceptor or both, leading to the conditions of matching vs. mismatching stereochemical preferences. The particular focus of the review is made on the practical aspects of the methodology under discussion and mechanistic considerations.

  17. STS-107 Crew Interviews: Michael Anderson, Mission Specialist

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-107 Mission Specialist 3 and Payload Commander Michael Anderson is seen during this preflight interview, where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. He outlines his role in the mission in general, and specifically in conducting onboard science experiments. He discusses the following instruments and sets of experiments in detail: CM2 (Combustion Module 2), FREESTAR (Fast Reaction Enabling Science Technology and Research, MEIDEX (Mediterranean Israeli Dust Experiment) and MGM (Mechanics of Granular Materials). Anderson also mentions on-board activities and responsibilities during launch and reentry, mission training, and microgravity research. In addition, he touches on the dual work-shift nature of the mission, the use of crew members as research subjects including pre and postflight monitoring activities, the emphasis on crew safety during training and the value of international cooperation.

  18. Theoretical study on the reaction mechanisms of Michael chirality addition between propionaldehyde and nitroalkene catalyzed by an enantioselective catalyst.

    PubMed

    Zhou, Xinming; Li, Ling; Sun, Xuejun; Wang, Yajun; Du, Dongmei; Fu, Hui

    2018-06-01

    The asymmetric Michael addition between propionaldehyde and nitroalkene catalyzed by 8-(ethoxycarbonyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid has obtained relatively high yields and excellent enantioselectivities at room temperature. In this study, the molecular structures and optical activity of the most stable conformation I are optimized at B3LYP/6-311++ G(d,p) level. We find that levorotatory conformation I catalyzing the same Michael addition can produce laevo-product A and dextrorotatory conformation I' can obtain the dextral-product A'. These results have guiding significance for further studying on the new chemzymes and the mechanism of the obtained different chiral products. © 2018 Wiley Periodicals, Inc.

  19. Chiral N,N'-Dioxide-Organocatalyzed Regio-, Diastereo- and Enantioselective Michael Addition-Alkylation Reaction.

    PubMed

    Feng, Juhua; Yuan, Xiao; Luo, Weiwei; Lin, Lili; Liu, Xiaohua; Feng, Xiaoming

    2016-10-24

    A highly regio-, diastereo- and enantioselective Michael addition-alkylation reaction between α-substituted cyano ketones and (Z)-bromonitrostyrenes has been realized by using a chiral N,N'-dioxide as organocatalyst. A variety of substrates performed well in this reaction, and the corresponding multifunctionalized chiral 2,3-dihydrofurans were obtained in up to 95 % yield with 95:5 dr and 93 % ee. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. Recollections of Jack Michael and the Application of Skinner's Analysis of Verbal Behavior

    ERIC Educational Resources Information Center

    Sundberg, Mark L.

    2017-01-01

    Jack Michael offered a course on verbal behavior almost every year throughout his teaching career. Jack was also interested in the application of Skinner's work and in 1976 began to offer a graduate course at Western Michigan University titled Verbal Behavior Applications. Jack and his students pursued the application of Skinner's work on verbal…

  1. St. Michael's Improvement Program - A Collaborative Approach to Sustainable Cost Savings.

    PubMed

    Trafford, Anne; Jane, Danielle

    2017-01-01

    In response to a challenging financial environment and increasing patient demand, St. Michael's Hospital needed to find long-term sustainable solutions to continue to provide high-quality patient care and invest in key priorities. By conducting Operational Reviews in focused areas, the hospital achieved $7.4 million of in-year savings in the first year, found standardizations, process efficiencies and direct cost savings that positioned itself for success in future funding models. Initiatives were grounded in evidence and relied heavily on the effective execution by the leadership, front-line staff and physicians. As organizations face similar challenges, this journey can provide key learnings.

  2. Invited Commentary: Continuing to Loosen the Constraints on Epidemiology in an Age of Change-A Comment on McMichael's "Prisoners of the Proximate".

    PubMed

    Galea, Sandro

    2017-06-01

    Published in 1999, McMichael's "Prisoners of the Proximate: Loosening the Constraints on Epidemiology in an Age of Change" (Am J Epidemiol. 1999;149(10):887-897) outlined an exciting vision for epidemiology as the field that that can help us better understand the drivers of population health so that we may intervene, paving the way for healthier populations. McMichael's paper remains today what it was when it was first published: clear, thoughtful, provocative, and usefully prescriptive in its call to action. McMichael identified 4 constraints facing epidemiology. The field has risen to this challenge and addressed some of these constraints. I discuss how successful (or not) we have been in addressing each of these 4 challenges. © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. STS-107 Payload Commander Michael Anderson during TCDT M113 training activities

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- -- STS-107 Payload Commander Michael Anderson takes a break during training on the operation of an M113 armored personnel carrier during Terminal Countdown Demonstration Test activities, a standard part of launch preparations. STS-107 is a mission devoted to research and will include more than 80 experiments that will study Earth and space science, advanced technology development, and astronaut health and safety. Launch is planned for Jan. 16, 2003, between 10 a.m. and 2 p.m. EST aboard Space Shuttle Columbia.

  4. ICAT: Integrating data infrastructure for facilities based science

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Flannery, Damian; Matthews, Brian; Griffin, Tom

    2009-12-21

    ICAT: Integrating data infrastructure for facilities based science Damian Flannery, Brian Matthews, Tom Griffin, Juan Bicarregui, Michael Gleaves, Laurent Lerusse, Roger Downing, Alun Ashton, Shoaib Sufi, Glen Drinkwater, Kerstin Kleese Abstract— Scientific facilities, in particular large-scale photon and neutron sources, have demanding requirements to manage the increasing quantities of experimental data they generate in a systematic and secure way. In this paper, we describe the ICAT infrastructure for cataloguing facility generated experimental data which has been in development within STFC and DLS for several years. We consider the factors which have influenced its design and describe its architecture and metadatamore » model, a key tool in the management of data. We go on to give an outline of its current implementation and use, with plans for its future development.« less

  5. Expedition 8 Crew Interviews: C. Michael Foale - CDR

    NASA Technical Reports Server (NTRS)

    2003-01-01

    C. Michael Foale, Commander of the Expedition 8 crew to the International Space Station (ISS), answers interview questions in this video. The questions cover: 1) The goals of the Expedition; 2) How his Mir experience prepared him for long-duration spaceflight; 3) The reaction the Columbia accident where he was training in Star City, Russia; 4) Why the rewards of spaceflight are worth the risks; 5) Why he wanted to become an astronaut; 6) His career path; 7) His influences; 8) His path of study; 9) His responsibilities on a mission; 10) What a Soyuz capsule is like; 11) What the oncoming and offgoing ISS crews will do together; 12) How the ISS science mission will be advanced during his stay; 13) Training and plans for extravehicular activity (EVA); 14) Return to Flight of Shuttle; 15) What is needed to make his mission a success; 16) The most valuable contribution of the ISS.

  6. STS-113 Mission Specialist Michael Lopez-Alegria looks over the P1 Truss

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist Michael Lopez-Alegria looks over the P1 Integrated Truss Structure, the primary payload for the mission. The P1 truss will be attached to the central truss segment, S0 Truss, during spacewalks. The payload also includes the Crew and Equipment Translation Aid (CETA) Cart B that can be used by spacewalkers to move along the truss with equipment. STS-113 is scheduled to launch Oct. 6, 2002.

  7. KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons each don an Emergency Life Support Apparatus (ELSA) during training on the proper use of the escape devices. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and NASA Space Shuttle Program Manager William Parsons each don an Emergency Life Support Apparatus (ELSA) during training on the proper use of the escape devices. NASA and United Space Alliance (USA) Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  8. KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, United Space Alliance (USA) Director of Orbiter Operations Patty Stratton, and NASA Space Shuttle Program Manager William Parsons view the underside of Shuttle Discovery in Orbiter Processing Facility Bay 3. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, United Space Alliance (USA) Director of Orbiter Operations Patty Stratton, and NASA Space Shuttle Program Manager William Parsons view the underside of Shuttle Discovery in Orbiter Processing Facility Bay 3. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  9. KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Associate Program Manager of Florida Operations Bill Pickavance (left front) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right front) tour a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Associate Program Manager of Florida Operations Bill Pickavance (left front) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right front) tour a solid rocket booster (SRB) retrieval ship at Cape Canaveral. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  10. A facile and efficient method of enzyme immobilization on silica particles via Michael acceptor film coatings: immobilized catalase in a plug flow reactor.

    PubMed

    Bayramoglu, Gulay; Arica, M Yakup; Genc, Aysenur; Ozalp, V Cengiz; Ince, Ahmet; Bicak, Niyazi

    2016-06-01

    A novel method was developed for facile immobilization of enzymes on silica surfaces. Herein, we describe a single-step strategy for generating of reactive double bonds capable of Michael addition on the surfaces of silica particles. This method was based on reactive thin film generation on the surfaces by heating of impregnated self-curable polymer, alpha-morpholine substituted poly(vinyl methyl ketone) p(VMK). The generated double bonds were demonstrated to be an efficient way for rapid incorporation of enzymes via Michael addition. Catalase was used as model enzyme in order to test the effect of immobilization methodology by the reactive film surface through Michael addition reaction. Finally, a plug flow type immobilized enzyme reactor was employed to estimate decomposition rate of hydrogen peroxide. The highly stable enzyme reactor could operate continuously for 120 h at 30 °C with only a loss of about 36 % of its initial activity.

  11. STS-114: Discovery Impromptu Briefing

    NASA Technical Reports Server (NTRS)

    2005-01-01

    Dr. Griffin, NASA Administrator, is accompanied by members of The U.S. House of Representatives in this STS-114 Discovery Impromptu briefing. The U.S. House of Representatives present include: Sherwood Boehlert, House Science Committee Chairman, Senator Hutchinson, Sheila Jackson, 18th Congressional District Texas, Al Green, 9th Congressional District, Representative Jim Davis, Florida, and Gene Green, 29th District, Texas. Griffin talks about the problem that occurred with the external fuel tank sensor of the Space Shuttle Discovery and the effort NASA is pursuing to track the problem, and identify the root cause. He answers questions from the news media about the next steps for the Space Shuttle Discovery, time frame for the launch, and activities for the astronauts for the next few days.

  12. HIGHLY DISATEREOSELECTIVE MICHAEL ADDITION OF FLAVANONE TO ITS CHALCONE PRECURSOR UNDER SOLVENT-FREE CONDITIONS USING MICROWAVES [POSTER

    EPA Science Inventory

    Substituted 2'-hydroxychalcones were found to give an equilibrium mixture of the starting chalcone and the corresponding flavanone inf 4.6-1:3 ratio in the presence of DBU gave two hitherto unknown diasteromeric dimers in a highly diastereoselective Michael addition of the carban...

  13. Jack Michael's Musings on the 60th Anniversary of Skinner's "Verbal Behavior"

    ERIC Educational Resources Information Center

    Esch, Barbara E.; Esch, John W.; Palmer, David C.

    2017-01-01

    When the B. F. Skinner Foundation reprinted Skinner's "Verbal Behavior" in 1992, Jack Michael wrote one of its two forewords, a detailed outline of the book's purpose and scope. On the 60th anniversary of the first publication (1957) of "Verbal Behavior", Jack reflects on the book's impact and its importance to the…

  14. STS-113 Mission Specialist Michael Lopez-Alegria suits up before launch

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. -- STS-113 Mission Specialist Michael Lopez-Alegria suits up before launch. This will be his third Shuttle flight. The primary mission is bringing the Expedition 6 crew to the Station and returning the Expedition 5 crew to Earth. The major objective of the mission is delivery of the Port 1 (P1) Integrated Truss Assembly, which will be attached to the port side of the S0 truss. Three spacewalks are planned to install and activate the truss and its associated equipment. Launch of Space Shuttle Endeavour on mission STS-113 is scheduled for Nov. 11 at 12:58 a.m. EST.

  15. STS-113 Mission Specialist Michael Lopez-Alegria suits up for launch

    NASA Technical Reports Server (NTRS)

    2002-01-01

    KENNEDY SPACE CENTER, FLA. - STS-113 Mission Specialist Michael Lopez-Alegria suits up for launch. He will be making his third Shuttle flight. The primary mission for the crew is bringing the Expedition 6 crew to the Station and returning the Expedition 5 crew to Earth. The major objective of the mission is delivery of the Port 1 (P1) Integrated Truss Assembly, which will be attached to the port side of the S0 truss. Three spacewalks are planned to install and activate the truss and its associated equipment. Launch of Space Shuttle Endeavour on mission STS-113 is scheduled for 8:15 p.m. EST.

  16. Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention.

    PubMed

    Li, Yan; Zhang, Li-Ping; Dai, Fang; Yan, Wen-Jing; Wang, Hai-Bo; Tu, Zhi-Shan; Zhou, Bo

    2015-09-09

    Curcumin, derived from the dietary spice turmeric, holds promise for cancer prevention. This prompts much interest in investigating the action mechanisms of curcumin and its analogues. Two symmetrical hexamethoxy-diarylpentadienones (1 and 2) as cucumin analogues were reported to possess significantly enhanced cytotoxicity compared with the parent molecule. However, the detailed mechanisms remain unclear. In this study, compounds 1 and 2 were identified as the G2/M cell cycle arrest agents to mediate the cytotoxicity toward NCI-H460 cells via Michael acceptor-dependent redox intervention. Compared with curcumin, they could more easily induce a burst of reactive oxygen species (ROS) and collapse of the redox buffering system. One possible reason is that they could more effectively target intracellular TrxR to convert this antioxidant enzyme into a ROS promoter. Additionally, they caused up-regulation of p53 and p21 and down-regulation of redox-sensitive Cdc25C along with cyclin B1/Cdk1 in a Michael acceptor- and ROS-dependent fashion. Interestingly, in comparison with compound 2, compound 1 displayed a relatively weak ability to generate ROS but increased cell cycle arrest activity and cytotoxicity probably due to its Michael acceptor-dependent microtubule-destabilizing effect and greater GST-inhibitory activity, as well as its enhanced cellular uptake. This work provides useful information for understanding Michael acceptor-dependent and redox-mediated cytotoxic mechanisms of curcumin and its active analogues.

  17. Catalyst-free and solvent-free Michael addition of 1,3-dicarbonyl compounds to nitroalkenes by a grinding method

    PubMed Central

    Xie, Zong-Bo; Wu, Ming-Yu; He, Ting; Le, Zhang-Gao

    2012-01-01

    Summary An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good to excellent yields by a grinding method under catalyst- and solvent-free conditions. PMID:22563352

  18. Gold (III) Chloride-Catalyzed 6-endo-trig Oxa-Michael Addition Reactions for Diastereoselective Synthesis of Fused Tetrahydropyranones

    PubMed Central

    Ciesielski, Jennifer; Lebœuf, David; Stern, Harry A.

    2013-01-01

    Alkynones were treated with boron trifluoride diethyl etherate to generate β-iodoallenolates, which underwent intramolecular aldol reactions to produce cycloalkenyl alcohols. Diastereoselective oxa-Michael ring closure could then be induced by treatment with a catalytic amount of gold(III) chloride, affording highly functionalized tetrahydropyran-containing ring systems. PMID:24032002

  19. Pyrrolidinyl-camphor derivatives as a new class of organocatalyst for direct asymmetric Michael addition of aldehydes and ketones to beta-nitroalkenes.

    PubMed

    Ting, Ying-Fang; Chang, Chihliang; Reddy, Raju Jannapu; Magar, Dhananjay R; Chen, Kwunmin

    2010-06-18

    Practical and convenient synthetic routes have been developed for the synthesis of a new class of pyrrolidinyl-camphor derivatives (7 a-h). These novel compounds were screened as catalysts for the direct Michael addition of symmetrical alpha,alpha-disubstituted aldehydes to beta-nitroalkenes. When this asymmetric transformation was catalyzed by organocatalyst 7 f, the desired Michael adducts were obtained in high chemical yields, with high to excellent stereoselectivities (up to 98:2 diastereomeric ratio (d.r.) and 99 % enantiomeric excess (ee)). The scope of the catalytic system was expanded to encompass various aldehydes and ketones as the donor sources. The synthetic application was demonstrated by the synthesis of a tetrasubstituted-cyclohexane derivative from (S)-citronellal, with high stereoselectivity.

  20. STS-113 Crew Interviews: Michael Lopez-Alegria, Mission Specialist 1

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-113 Mission Specialist 1 Michael Lopez-Alegria is seen during this preflight interview where he gives a quick overview of the mission before answering questions about his inspiration to become an astronaut and his career path. Lopez-Alegria outlines his role in the mission in general, and specifically during the docking and extravehicular activities (EVAs). He describes the payload (P1 truss) and the crew transfer activities (the crew of Expedition Six is replacing the crew of Expedition Five on the International Space Station (ISS)). Lopez-Alegria discusses the planned EVAs in detail and outlines what supplies will be left for the resident crew. He ends with his thoughts on the importance of the ISS as the second anniversary of human occupation of the Space Station approaches.

  1. Attending to hidden realities: contributions from the work of Michael Polanyi to supervision in pastoral care and counseling.

    PubMed

    Rodgerson, Thomas E

    2008-01-01

    In this article, the author suggests that concepts from the work of Michael Polanyi--such as the tacit dimension, subsidiary awareness, and commitment to a yet unrevealed, hidden reality--provide a theoretical basis for understanding the unique formation involved in pastoral care and counseling supervision.

  2. Diagnosis: Michael Moore--media paint filmmaker to be health care system's main problem.

    PubMed

    Kao, Caroline

    2008-01-01

    The media reporting on Sicko, Michael Moore's documentary about the failures of the U.S. health care system, provides an example of how corporate media continue to twist and restrict the much-needed debate on health care reform. Aside from an occasional concession that having 46 million uninsured Americans is indeed problematic, the media's hype-filled conversation on health care avoids the issues and echoes old myths about the dangers of "government-run" and "socialized" health care. But in the face of the media demonization, universal health care is remarkably popular among the public.

  3. Official Portrait of Astronaut Michael Collins

    NASA Technical Reports Server (NTRS)

    1967-01-01

    This is the official NASA portrait of astronaut Michael Collins. Collins chose an Air Force career following graduation from West Point. He served as an experimental flight test officer at the Air Force Flight Test Center, Edwards Air Force Base, California, and, in that capacity, tested performance and stability and control characteristics of Air Force aircraft, primarily jet fighters. Having logged approximately 5,000 hours flying time, Collins was one of the third group of astronauts named by NASA in October 1963. Collins completed two space flights, logging 266 hours in space, of which, 1 hour and 27 minutes was spent in Extra Vehicular Activity (EVA). On July 18, 1966, he served as backup pilot for the Gemini VII mission which included a successful rendezvous and docking with a separately launched Agena target vehicle and, using the power of the Agena, maneuvered the Gemini spacecraft into another orbit for a rendezvous with a second, passive Agena. His skillful performance in completing two periods of EVA included the recovery of a micrometeorite detection experiment from the passive Agena. July 16-24, 1969, Collins served as command module (CM) pilot on Apollo 11, the historic first lunar landing mission. He remained aboard the CM, Columbia, on station in lunar orbit and performed the final re-docking maneuvers following a successful lunar orbit rendezvous with the Lunar Module (LM), Eagle. Collins left NASA in January 1970.

  4. KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) technicians demonstrate the construction of a thermal blanket used in the Shuttle's thermal protection system for USA Vice President and Space Shuttle Program Manager Howard DeCastro (second from left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) technicians demonstrate the construction of a thermal blanket used in the Shuttle's thermal protection system for USA Vice President and Space Shuttle Program Manager Howard DeCastro (second from left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  5. KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with USA Vice President and Space Shuttle Program Manager Howard DeCastro and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From left, a United Space Alliance (USA) technician discusses aspects of Shuttle processing performed in the Solid Rocket Booster (SRB) Assembly and Refurbishment Facility (ARF) with USA Vice President and Space Shuttle Program Manager Howard DeCastro and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  6. KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) are briefed on the use of a cold plate in Orbiter Processing Facility Bay 2 by a USA technician (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (center) are briefed on the use of a cold plate in Orbiter Processing Facility Bay 2 by a USA technician (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  7. KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (third from left) watch as a USA technician (right) creates a tile for use in the Shuttle's Thermal Protection System (TPS). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (left) and NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (third from left) watch as a USA technician (right) creates a tile for use in the Shuttle's Thermal Protection System (TPS). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  8. N-heterocyclic carbene-catalyzed tandem aza-benzoin/Michael reactions: on site reversal of the reactivity of N-Boc imines.

    PubMed

    Wu, Ke-Jia; Li, Gong-Qiang; Li, Yi; Dai, Li-Xin; You, Shu-Li

    2011-01-07

    A tandem NHC-catalyzed aza-benzoin/Michael reaction has been developed as a method to efficiently produce dihydroindenones and pyrrolidinone-containing tricycles. The novel reaction pattern involves tert-butyl aryl(tosyl)methylcarbamates reacting as both electrophile and nucleophile on the same carbon.

  9. Jack Michael's Appointments at the University of Houston and Arizona State University: Reflections from a Former Student

    ERIC Educational Resources Information Center

    Mabry, John H.

    2016-01-01

    Jack Michael was an early enthusiast for what is now called applied behavior analysis. His many seminal contributions were through early publications in applied behavior analysis and the work of the students he trained (e.g., T. Ayllon, M. M. Wolf). His close mentorship of students earned him acclaim as a teacher along with his many theoretical…

  10. Effective Integration of Technology and Instruction. Q&A with Michael Jay. REL Mid-Atlantic Educator Effectiveness Webinar Series

    ERIC Educational Resources Information Center

    Regional Educational Laboratory Mid-Atlantic, 2015

    2015-01-01

    In this webinar, long-time educator and developer of education technology Michael Jay discussed the importance of using technology to support learning and gave examples of how teachers can integrate technology into their instruction based on the Common Core State Standards and the Next Generation Science Standards. The PowerPoint presentation and…

  11. Combining silver catalysis and organocatalysis: a sequential Michael addition/hydroalkoxylation one-pot approach to annulated coumarins.

    PubMed

    Hack, Daniel; Chauhan, Pankaj; Deckers, Kristina; Hermann, Gary N; Mertens, Lucas; Raabe, Gerhard; Enders, Dieter

    2014-10-03

    A highly stereoselective one-pot procedure for the synthesis of five-membered annulated hydroxycoumarins has been developed. By merging primary amine catalysis with silver catalysis, a series of functionalized coumarin derivatives were obtained in good yields (up to 91%) and good to excellent enantioselectivities (up to 99% ee) via a Michael addition/hydroalkoxylation reaction. Depending on the substituents on the enynone, the synthesis of annulated six-membered rings is also feasible.

  12. 78 FR 68102 - Atomic Safety and Licensing Board; In the Matter of Nuclear Innovation North America LLC (South...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ...] Atomic Safety and Licensing Board; In the Matter of Nuclear Innovation North America LLC (South Texas... Administrative Judges: Michael M. Gibson, Chairman, Dr. Gary S. Arnold, Dr. Randall J. Charbeneau. The Atomic... follows: Mail: Administrative Judge Michael M. Gibson, Atomic Safety and Licensing Board Panel, Mail Stop...

  13. Late Quaternary vegetation and climate history of the central Bering land bridge from St. Michael Island, western Alaska

    USGS Publications Warehouse

    Ager, T.A.

    2003-01-01

    Pollen analysis of a sediment core from Zagoskin Lake on St. Michael Island, northeast Bering Sea, provides a history of vegetation and climate for the central Bering land bridge and adjacent western Alaska for the past ???30,000 14C yr B.P. During the late middle Wisconsin interstadial (???30,000-26,000 14C yr B.P.) vegetation was dominated by graminoid-herb tundra with willows (Salix) and minor dwarf birch (Betula nana) and Ericales. During the late Wisconsin glacial interval (26,000-15,000 14C yr B.P.) vegetation was graminoid-herb tundra with willows, but with fewer dwarf birch and Ericales, and more herb types associated with dry habitats and disturbed soils. Grasses (Poaceae) dominated during the peak of this glacial interval. Graminoid-herb tundra suggests that central Beringia had a cold, arid climate from ???30,000 to 15,000 14C yr B.P. Between 15,000 and 13,000 14C yr B.P., birch shrub-Ericales-sedge-moss tundra began to spread rapidly across the land bridge and Alaska. This major vegetation change suggests moister, warmer summer climates and deeper winter snows. A brief invasion of Populus (poplar, aspen) occurred ca. 11,000-9500 14C yr B.P., overlapping with the Younger Dryas interval of dry, cooler(?) climate. During the latest Wisconsin to middle Holocene the Bering land bridge was flooded by rising seas. Alder shrubs (Alnus crispa) colonized the St. Michael Island area ca. 8000 14C yr B.P. Boreal forests dominated by spruce (Picea) spread from interior Alaska into the eastern Norton Sound area in middle Holocene time, but have not spread as far west as St. Michael Island. ?? 2003 University of Washington. Published by Elsevier Inc. All rights reserved.

  14. What I Think I May Have Learned--Reflections on 50 Years of Teaching: An Interview with Michael Wertheimer

    ERIC Educational Resources Information Center

    Michael, Kurt D.

    2006-01-01

    Kurt Michael is an associate professor in the Department of Psychology at Appalachian State University (ASU) where he teaches history and systems of psychology, abnormal psychology, child psychopathology, and interventions for children and adolescents. He received his BA (cum laude) from the University of Colorado at Boulder and his MS and PhD in…

  15. An improved procedure to prepare 3-methyl-4-nitroalkylenethylisoxazoles and their reaction under catalytic enantioselective Michael addition with nitromethane.

    PubMed

    Moccia, Maria; Wells, Robert J; Adamo, Mauro F A

    2015-02-21

    Herein, we describe a short synthesis of 3-methyl-4-nitro-5-alkylethenyl isoxazoles and their reactivity as Michael acceptors. The title compounds reacted with nitromethane under phase-transfer catalysis to provide highly enantioenriched adducts (up to 93% ee) which were then converted to the corresponding γ-nitroacids.

  16. Diastereoselective auxiliary- and catalyst-controlled intramolecular aza-Michael reaction for the elaboration of enantioenriched 3-substituted isoindolinones. Application to the synthesis of a new pazinaclone analogue

    PubMed Central

    Sallio, Romain; Lebrun, Stéphane; Capet, Frédéric; Agbossou-Niedercorn, Francine

    2018-01-01

    A new asymmetric organocatalyzed intramolecular aza-Michael reaction by means of both a chiral auxiliary and a catalyst for stereocontrol is reported for the synthesis of optically active isoindolinones. A selected cinchoninium salt was used as phase-transfer catalyst in combination with a chiral nucleophile, a Michael acceptor and a base to provide 3-substituted isoindolinones in good yields and diastereomeric excesses. This methodology was applied to the asymmetric synthesis of a new pazinaclone analogue which is of interest in the field of benzodiazepine-receptor agonists. PMID:29623121

  17. A Philosophy of Jewish Education in Question Marks: A Possible Reading of Michael Rosenak's Last Speech

    ERIC Educational Resources Information Center

    Rosenak, Avinoam

    2014-01-01

    Writing this article presents me with an opportunity to look closely at the last speech that my father and mentor, Professor Michael (Mike) Rosenak z"l gave before his passing in 2013. I will write about this speech from a perspective that is based on my intimate familiarity with the questions that concerned him throughout his life. I will…

  18. Michael Francis Madelin (1931--2007): a pioneer in the biology and ecology of conidial fungi and slime moulds.

    PubMed

    Campbell, Richard

    2008-12-01

    Michael F Madelin (1931--2007) was Programme Secretary, Vice-President, and President of the British Mycological Society. A summary of his research on Coprinopsis, various conidial fungi, Coelomomyces and myxomycetes is presented, with a full list of his publications. His teaching career was initially at Imperial College, University of London, and then mostly at the University of Bristol.

  19. A Symposium on the Relevance of Michael Polanyi's Insights to a Reformulated Understanding of Science, Technology, and Society

    ERIC Educational Resources Information Center

    Mead, Walter B.

    2011-01-01

    This is intended as an introductory statement to the explorations undertaken in the essays that follow. The authors of these essays attempt to introduce the reader to some of the insights of Michael Polanyi and their implications for the reader who wishes to come to a greater understanding of modern technological society, which--for better or…

  20. KENNEDY SPACE CENTER, FLA. -- NASA Associate Administrator for Space Flight William F. Readdy addresses the family members of the STS-107 astronauts, other dignitaries, members of the university community and the public gathered for the dedication ceremony of the Columbia Village at the Florida Institute of Technology in Melbourne, Fla. Each of the seven new residence halls in the complex is named for one of the STS-107 astronauts who perished during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon.

    NASA Image and Video Library

    2003-10-28

    KENNEDY SPACE CENTER, FLA. -- NASA Associate Administrator for Space Flight William F. Readdy addresses the family members of the STS-107 astronauts, other dignitaries, members of the university community and the public gathered for the dedication ceremony of the Columbia Village at the Florida Institute of Technology in Melbourne, Fla. Each of the seven new residence halls in the complex is named for one of the STS-107 astronauts who perished during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon.

  1. KENNEDY SPACE CENTER, FLA. -- NASA and United Space Alliance (USA) Space Shuttle program managers attend a briefing, part of activities during a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC. Starting third from left are NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, USA Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Space Shuttle Program Manager William Parsons, and USA Associate Program Manager of Ground Operations Andy Allen.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- NASA and United Space Alliance (USA) Space Shuttle program managers attend a briefing, part of activities during a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC. Starting third from left are NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, USA Vice President and Space Shuttle Program Manager Howard DeCastro, NASA Space Shuttle Program Manager William Parsons, and USA Associate Program Manager of Ground Operations Andy Allen.

  2. KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility Bay 1, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (right) are briefed by a USA technician (center) on Shuttle processing in the payload bay of orbiter Atlantis. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- In Orbiter Processing Facility Bay 1, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik (left) and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro (right) are briefed by a USA technician (center) on Shuttle processing in the payload bay of orbiter Atlantis. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  3. KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro are briefed on the properties of the tile used in the Shuttle's Thermal Protection System (TPS) by USA Manager of the TPS Facility Martin Wilson (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From left, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik and United Space Alliance (USA) Vice President and Space Shuttle Program Manager Howard DeCastro are briefed on the properties of the tile used in the Shuttle's Thermal Protection System (TPS) by USA Manager of the TPS Facility Martin Wilson (right). NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  4. [Early career of Michael Sendivogius].

    PubMed

    Prinke, Rafał T

    2012-01-01

    One of the most influential alchemical authors of the early modern period was Michael Sendivogius whose early life is shrouded in mystery. He may be labelled the most famous Polish scientific writer between Copernicus and Marie Skłodowska-Curie, but because of the difficulties involved in researching the biography of any alchemist, there has been relatively little interest in him among Polish historians. The early work of Roman Bugaj (author of the still fundamental monograph) and Włodzimierz Hubicki (who made his research available to the international community) has been continued only by the English-born Zbigniew Szydło and the author of this article. The roots of many legends about Sendivogius were three mid-17th century short biographies, none of which is trustworthy, so it is crucial to verify the received myth and the version constructed in the 1960's and 1970's with primary sources and evidence from the recent "new historiography of alchemy". The present article examines them in the light of newly discovered sources and reinterpretation of the old ones. The genealogy of the Sedzimir family is discussed at length to show that Sendivogius most probably was not its member but only a pretender in order to assume (or prove) the status of a nobleman. Several possible hypotheses about his origins are presented. He is known to have studied at three universities (Leipzig, Vienna and Altdorf) but authors of early panegyrics dedicated to Sendivogius list more universities which he may have attended. The most interesting is that of Cambridge, listed as the first one, because practically no Poles or Czechs went there at the time. Finally, his marriage to Veronica Stiebar, a wealthy widow of a Franconian knightly family, and her interesting family relationships (links to Erasmus, Camerarius, Paracelsus and the original Doctor Faustus) are discussed. The period covered is that before Sendivogius moved to Prague in about 1597, having already been a courtier of Rudolf II

  5. Michael Hauskeller: Sex and the Posthuman Condition : Palgrave-Macmillan, 2014, 98 pp.

    PubMed

    Miller, Lantz Fleming

    2016-10-01

    This new book from Michael Hauskeller explores the currently marketed or projected sex/love products that exhibit some trait of so-called "posthumanistic" theory or design. These products are so designated because of their intention to fuse high technologies, including robotics and computing, with the human user. The author offers several arguments for why the theory behind these products leads to inconsistencies. The book uses a unique approach to philosophical argument by enmeshing the argument's major points in a concomitant discussion of pieces from world literature pertaining to posthumanism. The method is compelling, heightened by great world authorial insights that rarely find their way into philosophy and shores up some strong argumentative points. Yet some of the argument still needs more elucidating.

  6. Efficient synthesis of optically active 4-nitro-cyclohexanones via bifunctional thiourea-base catalyzed double-Michael addition of nitromethane to dienones.

    PubMed

    Wu, Bin; Liu, Guo-Gui; Li, Mei-Qiu; Zhang, Yong; Zhang, Shao-Yun; Qiu, Jun-Ru; Xu, Xiao-Ping; Ji, Shun-Jun; Wang, Xing-Wang

    2011-04-07

    Thiourea-modified cinchona alkaloids as bifunctional catalysts and a base could catalyze a stepwise [5+1] cyclization of divinyl ketones with nitromethane via double Michael additions, furnishing optically active 4-nitro-cyclohexanones with good yields, excellent diastereoselectivities (>20 : 1) and high enantiomeric ratios (up to 97 : 3).

  7. Michael Addition Polymerization of Trifunctional Amine and Acrylic Monomer: A Versatile Platform for Development of Biomaterials.

    PubMed

    Cheng, Weiren; Wu, Decheng; Liu, Ye

    2016-10-10

    Michael addition polymerizations of amines and acrylic monomers are versatile approaches to biomaterials for various applications. A combinatorial library of poly(β-amino ester)s and diverse poly(amido amine)s from diamines and diacrylates or bis(acrylamide)s have been reported, respectively. Furthermore, novel linear and hyperbranched polymers from Michael addition polymerizations of trifunctional amines and acrylic monomers significantly enrich this category of biomaterials. In this Review, we focus on the biomaterials from Michael addition polymerizations of trifunctional amines and acrylic monomers. First we discuss how the polymerization mechanisms, which are determined by the reactivity sequence of the three types of amines of trifunctional amines, i.e., secondary (2°) amines (original), primary (1°) amines, and 2° amines (formed), are affected by the chemistry of monomers, reaction temperature, and solvent. Then we update how to design and synthesize linear and hyperbranched polymers based on the understanding of polymerization mechanisms. Linear polymers containing 2° amines in the backbones can be obtained from polymerizations of diacrylates or bis(acrylamide)s with equimolar trifunctional amine, and several approaches, e.g., 2A 2 +BB'B″, A 3 +2BB'B', A 2 +BB'B″, to hyperbranched polymers are developed. Further through molecular design of monomers, conjugation of functional species to 2° amines in the backbones of linear polymers and the abundant terminal groups of hyperbranched polymers, the amphiphilicity of polymers can be adjusted, and additional stimuli, e.g., thermal, redox, reactive oxidation species (ROS), and light, responses can be integrated with the intrinsic pH response. Finally we discuss the applications of the polymers for gene/drug delivery and bioimaging through exploring their self-assemblies in various motifs, e.g., micelles, polyplexes particles/nanorings and hydrogels. Redox-responsive hyperbranched polymers can display 300

  8. Comparative Biochemistry and Metabolism. Part 1. Carcinogenesis

    DTIC Science & Technology

    1981-10-01

    qualitatively equivalent to administration of a strong alkylating agent ; this may add another consideration to Roberts’ hypothesis, but ultimately the effect...Removal, Arch. Pathol. 12:186-202. Karran, P., T. Lindahl and B. Griffin, (1979), Adaptive Responses to Alkylating Agents Involves Alterative In Situ of...the Adaptive Response to Alkylating Agents , Nature (Lond.) 280:74-76. Ruchirawat, M., (1974), Relationship Between Metabolism and Toxicity of

  9. NASA Administrator Paine and U.S. President Richard Milhous Nixon Await Apollo 11 Splashdown

    NASA Technical Reports Server (NTRS)

    1969-01-01

    Dr. Thomas Paine, NASA administrator (left) and U.S. President Richard Milhous Nixon wait aboard the recovery ship, the U.S.S. Hornet, for splashdown of the Apollo 11 in the Pacific Ocean. Navy para-rescue men recovered the capsule housing the 3-man crew. The crew was taken to safety aboard the U.S.S. Hornet, where they were quartered in a Mobile Quarantine Facility (MQF). The Apollo 11 mission, the first manned lunar mission, launched from the Kennedy Space Center, Florida via the Saturn V launch vehicle on July 16, 1969 and safely returned to Earth on July 24, 1969. The Saturn V vehicle was developed by the Marshall Space Flight Center (MSFC) under the direction of Dr. Wernher von Braun. Aboard were Neil A. Armstrong, commander; Michael Collins, Command Module (CM) pilot; and Edwin E. Aldrin Jr., Lunar Module (LM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named 'Eagle'', carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. Armstrong was the first human to ever stand on the lunar surface, followed by Edwin (Buzz) Aldrin. During 2½ hours of surface exploration, the crew collected 47 pounds of lunar surface material for analysis back on Earth. With the success of Apollo 11, the national objective to land men on the Moon and return them safely to Earth had been accomplished.

  10. Michael Novak's "Business as a Calling" as a Vehicle for Addressing Ethical and Policy Concerns in a Business Law Course

    ERIC Educational Resources Information Center

    Murphy, Tonia Hap

    2008-01-01

    This article describes the author's experience of incorporating Michael Novak's "Business as a Calling: Work and the Examined Life" into a Business Law course. The author views it as a positive addition to the course, one that may be of interest to her colleagues at other institutions. Accordingly, after an overview of Novak's analysis in…

  11. Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives

    PubMed Central

    Al-Majid, Abdullah M.; Barakat, Assem; AL-Najjar, Hany J.; Mabkhot, Yahia N.; Ghabbour, Hazem A.; Fun, Hoong-Kun

    2013-01-01

    A simple protocol, involving the green synthesis for the construction of novel bis-pyrimidine derivatives, 3a–i and 4a–e are accomplished by the aqueous diethylamine media promoted tandem Aldol-Michael reaction between two molecules of barbituric acid derivatives 1a,b with various aldehydes. This efficient synthetic protocol using an economic and environmentally friendly reaction media with versatility and shorter reaction time provides bis-pyrimidine derivatives with high yields (88%–99%). PMID:24317435

  12. Michael E. Lamb: Award for Distinguished Senior Career Contributions to Psychology in the Public Interest.

    PubMed

    2015-11-01

    The APA Awards for Distinguished Contributions to Psychology in the Public Interest recognize persons who have advanced psychology as a science and/or profession by a single extraordinary achievement or a lifetime of outstanding contributions in the public interest. The 2015 co-recipient of the Award for Distinguished Senior Career Contributions to Psychology in the Public Interest is Michael E. Lamb. Lamb was selected because his "work profoundly shaped the fields of developmental psychology, social welfare, child and family policy, and law." Lamb's award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).

  13. A colorimetric detection of acrylamide in potato chips based on nucleophile-initiated thiol-ene Michael addition.

    PubMed

    Hu, Qinqin; Fu, Yingchun; Xu, Xiahong; Qiao, Zhaohui; Wang, Ronghui; Zhang, Ying; Li, Yanbin

    2016-02-07

    Acrylamide (AA), a neurotoxin and a potential carcinogen, has been found in various thermally processed foods such as potato chips, biscuits, and coffee. Simple, cost-effective, and sensitive methods for the rapid detection of AA are needed to ensure food safety. Herein, a novel colorimetric method was proposed for the visual detection of AA based on a nucleophile-initiated thiol-ene Michael addition reaction. Gold nanoparticles (AuNPs) were aggregated by glutathione (GSH) because of a ligand-replacement, accompanied by a color change from red to purple. In the presence of AA, after the thiol-ene Michael addition reaction between GSH and AA with the catalysis of a nucleophile, the sulfhydryl group of GSH was consumed by AA, which hindered the subsequent ligand-replacement and the aggregation of AuNPs. Therefore, the concentration of AA could be determined by the visible color change caused by dispersion/aggregation of AuNPs. This new method showed high sensitivity with a linear range from 0.1 μmol L(-1) to 80 μmol L(-1) and a detection limit of 28.6 nmol L(-1), and especially revealed better selectivity than the fluorescence sensing method reported previously. Moreover, this new method was used to detect AA in potato chips with a satisfactory result in comparison with the standard methods based on chromatography, which indicated that the colorimetric method can be expanded for the rapid detection of AA in thermally processed foods.

  14. STS-92 M.S. Michael Lopez-Alegria suits up for launch

    NASA Technical Reports Server (NTRS)

    2000-01-01

    During suitup in the Operations and Checkout Building, STS-92 Mission Specialist Michael E. Lopez-Alegria smiles and clasps his hands in anticipation of a second launch attempt. He and the rest of the crew will be heading out to the Astrovan for the ride to Launch Pad 39A. During the 11-day mission to the International Space Station, four extravehicular activities (EVAs), or spacewalks, are planned for construction. The payload includes the Integrated Truss Structure Z-1 and the third Pressurized Mating Adapter. The Z-1 truss is the first of 10 that will become the backbone of the Space Station, eventually stretching the length of a football field. PMA-3 will provide a Shuttle docking port for solar array installation on the sixth Station flight and Lab installation on the seventh Station flight. Launch is scheduled for 7:17 p.m. EDT. Landing is expected Oct. 22 at 2:10 p.m. EDT.

  15. Michael Faraday on the Learning of Science and Attitudes of Mind

    NASA Astrophysics Data System (ADS)

    Crawford, Elspeth

    The paper makes use of Michael Faraday's ideas about learning, in particular his thoughts about attitudes to the unknowns of science and the development of an attitude which improves scientific decision-making. An invented scenario involving nursery school children demonstrates some attitudes displayed there. Discussion of the scenario and variation in possible outcomes suggests that Faraday's views are relevant to scientific learning in general. The main thesis of the paper is that it is central to learning in science to acknowledge that there is an inner struggle involved in facing unknowns, and that empathy with the fears and expectations of learners is an essential quality if genuinely scientific thought is to develop. It is suggested, following Faraday, that understanding our own feelings while we teach is a pre-requisite to enabling such empathy and that only then will we be in a position to evaluate accurately whether or not our pupils are thinking scientifically.

  16. New Light on the Alchemical Writings of Michael Sendivogius (1566-1636).

    PubMed

    Prinke, Rafał T

    2016-08-01

    The Polish alchemist Michael Sendivogius is best known for the influential Novum lumen chymicum, a work composed of three separate texts. Sendivogius's authorship was questioned in the mid-seventeenth century, and these reservations are still held by some modern historians. On the other hand, other early modern and modern readers not only accepted his authorship of all three texts, but also ascribed as many as eleven texts to him. This paper discusses the key works published under the anagrammatised name of Sendivogius with the aim of resolving the authorship question. Newly discovered evidence makes it possible to trace the circumstances leading to the publication of these works in much greater detail than previously, and to present new arguments affirming Sendivogius's authorship. In the Tractatus de sulphure, Sendivogius promised to write another two treatises, which readers sought to identify and (in some cases) to write themselves. This paper sets out, and rejects, the arguments for including them in the corpus of genuine Sendivogian writings.

  17. Lizards, ticks and contributions to Australian parasitology: C. Michael Bull (1947-2016).

    PubMed

    Godfrey, Stephanie S; Gardner, Michael G

    2017-12-01

    Professor C. Michael Bull was a great scientist and mentor, and an Associate Editor of this journal. While his research career spanned the fields of behavioural ecology, conservation biology and herpetology, in this article, we pay tribute to his major contribution to Australian parasitology. Mike authored more than eighty articles on host-parasite ecology, and revealed major insights into the biology and ecology of ticks from his long term study of the parapatric boundary of two tick species ( Amblyomma limbatum and Bothriocroton hydrosauri ) on the sleepy lizard ( Tiliqua rugosa ). In this article, we provide an overview of how this research journey developed to become one of the longest-running studies of lizards and their ticks, totalling 35 years of continuous surveys of ticks on lizards, and the insights and knowledge that he generated along that journey.

  18. Radiation therapy in the treatment of cervical cancer: The University of Chicago/Michael Reese Hospital experience

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rader, J.S.; Haraf, D.J.; Halpern, H.J.

    1990-07-01

    A retrospective analysis was conducted on 307 patients referred for radiation therapy at The University of Chicago and Michael Reese Hospital between 1971 and 1986. Median follow-up was 6.4 years. Treatment techniques varied during the time of the study. Actuarial disease-free survivals were 78%, 64%, 55%, 33%, 41%, and 60% for stage IB, IIA, IIB, IIIA, IIIB, and IVA, respectively. Stage, size of the cervical lesion, and hemoglobin level during treatment were prognostic factors. Treatment technique as well as time dose factors were analyzed with respect to survival, failures, and complications.

  19. Are Claims of Global Warming Being Suppressed?

    NASA Astrophysics Data System (ADS)

    Crowley, Thomas J.

    2006-02-01

    Over the last few years, I have heard many rumors that climate science relevant to the global warming discussion is being suppressed by the Bush Administration. One cannot do much about third-hand information. However, on 29 January, the New York Times published a front page article on NASA efforts to suppress statements about global warming by James Hansen, director of the NASA Goddard Institute for Space Studies. A claim by one government scientist, though, no matter how distinguished, still requires examples from other scientists before a general conclusion can be drawn about the overall scope of the problem. But if the charges are more widespread, then some government scientists might be reluctant to make such claims, because they might feel that their positions were jeopardized. Therefore, an alternate way may be needed to determine the scope of the issue, while still safeguarding government workers from possible retaliation. -On 30 January, Rep. Sherwood Boehlert (R-N.Y.), chairman of the U.S. House of Representatives Committee on Science, wrote a letter to NASA Administrator Michael Griffin addressing many of the concerns Crowley has raised. Boehlert wrote,``It ought to go without saying that government scientists must be free to describe their scientific conclusions and the implications of those conclusions to their fellow scientists, policymakers and the general public.'' He continued,``Good science cannot long persist in an atmosphere of intimidation. Political figures ought to be reviewing their public statements to make sure they are consistent with the best available science; scientists should not be reviewing their statements to make sure they are consistent with the current political orthodoxy.'' I commend Rep. Boehlert for his quick and clear statement of the importance of unfettered communication of science. -FRED SPILHAUS, Editor

  20. Enantioselective total synthesis of (-)-strychnine using the catalytic asymmetric Michael reaction and tandem cyclization.

    PubMed

    Ohshima, Takashi; Xu, Youjun; Takita, Ryo; Shimizu, Satoshi; Zhong, Dafang; Shibasaki, Masakatsu

    2002-12-11

    The enantioselective total synthesis of (-)-strychnine was accomplished through the use of the highly practical catalytic asymmetric Michael reaction (0.1 mol % of (R)-ALB, more than kilogram scale, without chromatography, 91% yield and >99% ee) as well as a tandem cyclization that simultaneously constructed B- and D-rings (>77% yield). Moreover, newly developed reaction conditions for thionium ion cyclization, NaBH3CN reduction of the imine moiety in the presence of Lewis acid to prevent ring opening reaction, and chemoselective reduction of the thioether (desulfurization) in the presence of exocyclic olefin were pivotal to complete the synthesis. The described chemistry paves the way for the synthesis of more advanced Strychnos alkaloids.

  1. A Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates.

    PubMed

    Garrabou, Xavier; Beck, Tobias; Hilvert, Donald

    2015-05-04

    Recent advances in computational design have enabled the development of primitive enzymes for a range of mechanistically distinct reactions. Here we show that the rudimentary active sites of these catalysts can give rise to useful chemical promiscuity. Specifically, RA95.5-8, designed and evolved as a retro-aldolase, also promotes asymmetric Michael additions of carbanions to unsaturated ketones with high rates and selectivities. The reactions proceed by amine catalysis, as indicated by mutagenesis and X-ray data. The inherent flexibility and tunability of this catalyst should make it a versatile platform for further optimization and/or mechanistic diversification by directed evolution. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. 'Introducing Michael Gove to Loïc Wacquant': Why Social Work Needs Critical Sociology.

    PubMed

    Michael Garrett, Paul

    2016-06-01

    In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the 'agency' of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015.

  3. KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush from NASA Headquarters stating his goals for NASA’s new mission. Seated in the front row, left to right, are Ken Aguilar, chief, Equal Opportunity office; Lisa Malone, director of External Affairs; Bruce Buckingham, assistant to Dr. Woodrow Whitlow, KSC deputy director; Dr. Whitlow; Shannon Roberts, with External Affairs; Howard DeCastro, vice president and Space Shuttle program manager, United Space Alliance; and Bill Pickavance vice president and associate program manager of Florida Operations, USA. The President’s goals are completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

    NASA Image and Video Library

    2004-01-14

    KENNEDY SPACE CENTER, FLA. -- KSC management and other employees gather in the Center’s television studio to watch the address by President George W. Bush from NASA Headquarters stating his goals for NASA’s new mission. Seated in the front row, left to right, are Ken Aguilar, chief, Equal Opportunity office; Lisa Malone, director of External Affairs; Bruce Buckingham, assistant to Dr. Woodrow Whitlow, KSC deputy director; Dr. Whitlow; Shannon Roberts, with External Affairs; Howard DeCastro, vice president and Space Shuttle program manager, United Space Alliance; and Bill Pickavance vice president and associate program manager of Florida Operations, USA. The President’s goals are completing the International Space Station, retiring the Space Shuttle orbiters, developing a new crew exploration vehicle, and returning to the moon and beyond within the next two decades. Pres. Bush was welcomed by NASA Administrator Sean O’Keefe and Expedition 8 Commander Michael Foale, who greeted him from the International Space Station. Members of the Washington, D.C., audience included astronauts Eileen Collins, Ed Lu and Michael Lopez-Alegria, and former astronaut Gene Cernan.

  4. A rapid, one-pot, microwave-influenced synthesis of spiro-2,5-diketopiperazines via a cascade Ugi/6-exo-trig aza-Michael reaction.

    PubMed

    Santra, Soumava; Andreana, Peter R

    2011-04-01

    A rapid, cascade reaction process has been developed to access biologically validated spiro-2,5-diketopiperazines. The facile and environmentally benign method capitalizes on commercially available starting reagents for a sequential Ugi/6-exo-trig aza-Michael reaction, water as a solvent, and microwave irradiation without any extraneous additives.

  5. Mechanistic Kinetic Modeling of Thiol-Michael Addition Photopolymerizations via Photocaged "Superbase" Generators: An Analytical Approach.

    PubMed

    Claudino, Mauro; Zhang, Xinpeng; Alim, Marvin D; Podgórski, Maciej; Bowman, Christopher N

    2016-11-08

    A kinetic mechanism and the accompanying mathematical framework are presented for base-mediated thiol-Michael photopolymerization kinetics involving a photobase generator. Here, model kinetic predictions demonstrate excellent agreement with a representative experimental system composed of 2-(2-nitrophenyl)propyloxycarbonyl-1,1,3,3-tetramethylguanidine (NPPOC-TMG) as a photobase generator that is used to initiate thiol-vinyl sulfone Michael addition reactions and polymerizations. Modeling equations derived from a basic mechanistic scheme indicate overall polymerization rates that follow a pseudo-first-order kinetic process in the base and coreactant concentrations, controlled by the ratio of the propagation to chain-transfer kinetic parameters ( k p / k CT ) which is dictated by the rate-limiting step and controls the time necessary to reach gelation. Gelation occurs earlier as the k p / k CT ratio reaches a critical value, wherefrom gel times become nearly independent of k p / k CT . The theoretical approach allowed determining the effect of induction time on the reaction kinetics due to initial acid-base neutralization for the photogenerated base caused by the presence of protic contaminants. Such inhibition kinetics may be challenging for reaction systems that require high curing rates but are relevant for chemical systems that need to remain kinetically dormant until activated although at the ultimate cost of lower polymerization rates. The pure step-growth character of this living polymerization and the exhibited kinetics provide unique potential for extended dark-cure reactions and uniform material properties. The general kinetic model is applicable to photobase initiators where photolysis follows a unimolecular cleavage process releasing a strong base catalyst without cogeneration of intermediate radical species.

  6. Using Our Voices, Losing Our Bodies: Michael Brown, Trayvon Martin, and the Spirit Murders of Black Male Professors in the Academy

    ERIC Educational Resources Information Center

    Johnson, Lamar; Bryan, Nathaniel

    2017-01-01

    The recent deaths of Michael Brown, Trayvon Martin, and other Black males have generated new civil rights urgencies in Black communities and spirited academic discourses in higher education regarding the educational and social plight of Black males in America. Connecting the deaths of Black males to our lived experiences in the academy, we use a…

  7. What's in a Name? That Which We Call a Crisis? A Commentary on Michael Young's Article "Overcoming the Crisis in Curriculum Theory"

    ERIC Educational Resources Information Center

    Lundgren, Ulf P.

    2015-01-01

    Michael Young's article "Overcoming the crisis in curriculum theory: a knowledge-based approach" ("JCS, 45", 2) is discussed from the starting point that the claimed crisis is constructed from a decisive solution, that is the solution determines what is a crisis. But curriculum research and curriculum theory are in need of…

  8. S70-35594

    NASA Image and Video Library

    2008-08-07

    S70-35594 (18 April 1970) --- President Richard M. Nixon presents the Presidential Medal of Freedom to the Apollo 13 Mission Operations Team at Manned Spacecraft Center (MSC). Accepting for the team is Sigurd A. Sjoberg, director of Flight Operations at MSC. Dr. Thomas O. Paine, Administrator, National Aeronautics and Space Administration (NASA), is at left. Also seen here on the speaker's platform are Jeffrey C. Lovell, son of astronaut James A. Lovell Jr., commander of the Apollo 13 mission; Gerald D. Griffin (second from right) and Milton L. Windler, two of four flight directors who worked around the clock during the mission.

  9. Facile construction of macroporous hybrid monoliths via thiol-methacrylate Michael addition click reaction for capillary liquid chromatography.

    PubMed

    Lin, Hui; Ou, Junjie; Liu, Zhongshan; Wang, Hongwei; Dong, Jing; Zou, Hanfa

    2015-01-30

    A facile approach based on thiol-methacrylate Michael addition click reaction was developed for construction of porous hybrid monolithic materials. Three hybrid monoliths were prepared via thiol-methacrylate click polymerization by using methacrylate-polyhedral oligomeric silsesquioxane (POSS) (cage mixture, n=8, 10, 12, POSS-MA) and three multi-thiol crosslinkers, 1,6-hexanedithiol (HDT), trimethylolpropane tris(3-mercaptopropionate) (TPTM) and pentaerythritol tetrakis(3-mercaptopropionate) (PTM), respectively, in the presence of porogenic solvents (n-propanol and PEG 200) and a catalyst (dimethylphenylphosphine, DMPP). The obtained monoliths possessed high thermal and chemical stabilities. Besides, they all exhibited high column efficiencies and excellent separation abilities in capillary liquid chromatography (cLC). The highest column efficiency could reach ca. 195,000N/m for butylbenzene on the monolith prepared with POSS-MA and TPTM (monolith POSS-TPTM) in reversed-phase (RP) mode at 0.64mm/s. Good chromatographic performance were all achieved in the separations of polycyclic aromatic hydrocarbons (PAHs), phenols, anilines, EPA 610 as well as bovine serum albumin (BSA) digest. The high column efficiencies in the range of 51,400-117,000N/m (achieved on the monolith POSS-PTM in RP mode) convincingly demonstrated the high separation abilities of these thiol-methacrylate based hybrid monoliths. All the results demonstrated the feasibility of the phosphines catalyzed thiol-methacrylate Michael addition click reaction in fabrication of monolithic columns with high efficiency for cLC applications. Copyright © 2014 Elsevier B.V. All rights reserved.

  10. KENNEDY SPACE CENTER, FLA. -- From left, United Space Alliance (USA) Deputy Space Shuttle Program Manager of Operations Loren Shriver, USA Associate Program Manager of Ground Operations Andy Allen, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and USA Vice President and Space Shuttle Program Manager Howard DeCastro examine a tile used in the Shuttle's Thermal Protection System (TPS) in KSC's TPS Facility. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

    NASA Image and Video Library

    2003-12-19

    KENNEDY SPACE CENTER, FLA. -- From left, United Space Alliance (USA) Deputy Space Shuttle Program Manager of Operations Loren Shriver, USA Associate Program Manager of Ground Operations Andy Allen, NASA Deputy Associate Administrator for Space Station and Shuttle Programs Michael Kostelnik, and USA Vice President and Space Shuttle Program Manager Howard DeCastro examine a tile used in the Shuttle's Thermal Protection System (TPS) in KSC's TPS Facility. NASA and USA Space Shuttle program management are participating in a leadership workday. The day is intended to provide management with an in-depth, hands-on look at Shuttle processing activities at KSC.

  11. Facile Iodine-Catalyzed Michael Addition of Indoles to α,α′-Bis(arylmethylene)cyclopentanones: An Efficient Synthesis of E-2-(3-Indolylphenylmethyl)-5-phenylmethylenecyclopentanones

    PubMed Central

    Pal, Rammohan; Das Gupta, Arpita; Mallik, Asok K.

    2012-01-01

    Iodine-catalyzed reaction of indoles with α,α′-bis(arylmethylene)cyclopentanones afforded one diastereomer of the corresponding Michael adducts, namely, E-2-(3-indolylphenylmethyl)-5-phenylmethylenecyclopentanones, in a good yield. The products form a new group of indole derivatives. PMID:24052849

  12. Michael Fordham and the Journal of Analytical Psychology: the view from Hangman's Hill.

    PubMed

    Urban, Elizabeth

    2015-09-01

    This short paper was presented to a conference in honour of the 60(th) year of the JAP and was one of others that acknowledged the contribution of Michael Fordham. The subtitle refers to the paper's overview of Fordham's published oeuvre and the particular place of the Journal of Analytical Psychology, for which he was the founding editor. Fordham's contribution to a Jungian-based model of development is discussed, with reference to his papers in the British Journal of Medical Psychology. The paper notes miscellaneous pieces from Fordham's commentaries, obituaries, papers and reviews which capture not only the development of Fordham as a thinker but also his character. There is discussion of his reviews of Melanie Klein's Envy and Gratitude and manuscripts by Erich Neumann. A reminiscence of Fordham as supervisor is recounted. © 2015, The Society of Analytical Psychology.

  13. Forty Years of "Pastoral Care": An Appraisal of Michael Marland's Seminal Book and Its Significance for Pastoral Care in Schools

    ERIC Educational Resources Information Center

    Best, Ron

    2014-01-01

    Michael Marland's seminal book: "Pastoral Care" was published 40 years ago this year. The thesis of the book--that pastoral care is the central task of the school, and must be planned and institutionalized through pastoral roles and structures--is explored against the background of the social, cultural and educational developments…

  14. The Impact of Socio-Cultural Differences on Educational Values: A Comparison of the Pedagogy of Michael Oakeshott and John McGahern

    ERIC Educational Resources Information Center

    Williams, Kevin

    2017-01-01

    The year 2016 marked the tenth anniversary of the death of John McGahern (born 1934), the widely acclaimed Irish author. There is a shared temper of mind and several common strands in the work of McGahern and that of the English philosopher, Michael Oakeshott (1900-1990). Despite the very different cultural environments in which they grew up and…

  15. ‘Introducing Michael Gove to Loïc Wacquant’: Why Social Work Needs Critical Sociology

    PubMed Central

    Michael Garrett, Paul

    2016-01-01

    In 2013, Michael Gove, then Secretary of State for Education and Health in the UK coalition government, criticised social workers for laying insufficient emphasis on the ‘agency’ of individuals and for being too preoccupied with social and economic inequalities. Such a perspective, which is not unique to Gove, needs to be countered by reaffirming the significance of an expansively critical sociology for social work. In this context, the thematic concerns of the French theorist, Loïc Wacquant, illuminates key aspects of social work engagement with clients which Gove and his ideological associates appear intent on ignoring. The issues raised have significant political resonances given the pending UK General Election taking place in May 2015. PMID:27559203

  16. Heterobimetallic Pd-Sn catalysis: Michael addition reaction with C-, N-, O-, and S-nucleophiles and in situ diagnostics.

    PubMed

    Das, Debjit; Pratihar, Sanjay; Roy, Sujit

    2013-03-15

    An efficient Michael addition reaction of differently substituted enones with carbon, sulfur, oxygen, and nitrogen nucleophiles has been achieved by a new heterobimetallic "Pd-Sn" catalyst system. The nature of the catalytically relevant species and their interactions with the enone moiety has been examined by spectroscopy. The effect of ligand and the coordination mode of enone with "Pd-Sn" heterobimetallic system have been investigated by kinetics and DFT studies. A straightforward application of this methodology is shown in the synthesis of 1,4-oxathiepane core.

  17. Organocatalytic Enantioselective Michael/Cyclization Domino Reaction between 3-Amideoxindoles and α,β-Unsaturated Aldehydes: One-Pot Preparation of Chiral Spirocyclic Oxindole-γ-lactams.

    PubMed

    Yang, Peng; Wang, Xiao; Chen, Feng; Zhang, Zheng-Bing; Chen, Chao; Peng, Lin; Wang, Li-Xin

    2017-04-07

    The first organocatalytic enantioselective Michael/cyclization domino reaction between 3-amideoxindoles and α,β-unsaturated aldehydes is described. After sequential oxidation with pyridinium chlorochromate, a direct and one-pot preparation of highly sterically hindered spirocyclic oxindole-γ-lactams was achieved in 51-81% yields with 75-97% ee and ≤80/20 dr.

  18. Review Article: Yamada, Jeni "Laura: A Case for the Modularity of Language"; Tomasello, Michael "First Verbs: A Case Study of Early Grammatical Development."

    ERIC Educational Resources Information Center

    Shatz, Marilyn

    1994-01-01

    Jeni Yamada's "Laura" and Michael Tomasello's "First Verbs" continue a tradition of providing useful information on the language ability of individuals in a depth rarely found in multisubject studies; however, these efforts are unusual for case studies in that both take strong theoretical positions on the essence of language and language learning.…

  19. "Integration was a Solution to Segregation, but Integration does not Address Quality Education": A Conversation about School Desegregation with Dr. Michael A. Middleton

    ERIC Educational Resources Information Center

    Diem, Sarah; Brooks, Jeffrey

    2013-01-01

    We conclude this special issue reflecting back on the history of desegregation and questioning how we move forward in trying to achieve racially integrated school settings. The epilogue includes a conversation with Dr. Michael A. Middleton, Deputy Chancellor of the University of Missouri-Columbia. Dr. Middleton is an expert in civil rights and…

  20. Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.

    PubMed

    Zang, Qin; Javed, Salim; Hill, David; Ullah, Farman; Bi, Danse; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H; Santini, Conrad; Organ, Michael G; Hanson, Paul R

    2012-08-13

    The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3 + 2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products.

  1. Automated Synthesis of a Library of Triazolated 1,2,5-Thiadiazepane 1,1-Dioxides via a Double aza-Michael Strategy

    PubMed Central

    Zang, Qin; Javed, Salim; Hill, David; Ullah, Farman; Bi, Danse; Porubsky, Patrick; Neuenswander, Benjamin; Lushington, Gerald H.; Santini, Conrad; Organ, Michael G.; Hanson, Paul R.

    2013-01-01

    The construction of a 96-member library of triazolated 1,2,5-thiadiazepane 1,1-dioxides was performed on a Chemspeed Accelerator (SLT-100) automated parallel synthesis platform, culminating in the successful preparation of 94 out of 96 possible products. The key step, a one-pot, sequential elimination, double-aza-Michael reaction, and [3+2] Huisgen cycloaddition pathway has been automated and utilized in the production of two sets of triazolated sultam products. PMID:22853708

  2. Diversity-oriented asymmetric catalysis (DOAC): stereochemically divergent synthesis of thiochromanes using an imidazoline-aminophenol-nickel-catalyzed Michael/Henry reaction.

    PubMed

    Arai, Takayoshi; Yamamoto, Yushi

    2014-03-21

    The (S,S)-diphenylethylenediamine-derived imidazoline-aminophenol-Ni complex catalyzed tandem asymmetric Michael/Henry reaction of 2-mercaptobenzaldehydes with β-nitrostyrenes to give the corresponding (2S,3R,4R)-2-aryl-3-nitrothiochroman-4-ols in up to 99% diastereoselectivity with 95% ee was demonstrated in diversity-oriented asymmetric catalysis. Reduction of the nitro group of the chiral thiochromanes gave a new series of (2S,3R,4R)-3-amino-2-arylthiochroman-4-ols with retention of the strereoselectivity.

  3. Enantioselective organocatalytic one-pot amination/aza-Michael/aldol condensation reaction sequence: synthesis of 3-pyrrolines with a quaternary stereocenter.

    PubMed

    Desmarchelier, Alaric; Coeffard, Vincent; Moreau, Xavier; Greck, Christine

    2012-10-08

    Primary amine-catalyzed direct conversion of α,α-disubstituted aldehydes into 3-pyrrolines with a quaternary stereocenter is reported. The one-pot enantioselective sequence is based on a α-amination, an aza-Michael addition of hydrazine, an aldol condensation dehydratation and proceeds with good yields and excellent levels of enantioselectivity. Synthetically attractive applications including the formation of aziridinopyrrolidine or epoxypyrrolidine derivatives with good yields and selectivities are also described. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Proceedings, Conference and Training Workshop on Wildlife Hazards to Aircraft Held at Charleston, South Carolina on 22-25 May 1984

    DTIC Science & Technology

    1984-05-25

    Aircraft ~.Aut@i~Michael J . Harrison/Sidney A. Gauthreaux, Jr., -Lilia A. Abron-Robinson .WeUi’N.(TiS 9. Pordoni,mg Ogon.m,t,. Nome and AdOda.0...Michael J . Harrison (AAS-330) 16. A4049ract , /-7hese proceedings were developed to enhance information exchange and improve understanding and control of...Wildlife Hazards to Aircraft S Conference and Training Workshop Edited by: Michael J . Harrison Federal Aviation Administration . Dr. Sidney A

  5. President Richard Nixon visits MSC to award Apollo 13 Mission Operations team

    NASA Image and Video Library

    1970-04-18

    S70-35600 (18 April 1970) --- President Richard M. Nixon introduces Sigurd A. Sjoberg (far right), director of Flight Operations at Manned Spacecraft Center, and the four Apollo 13 flight directors during the President?s post-mission visit to the Manned Spacecraft Center. The flight directors are, from left to right, Glynn S. Lunney, Eugene A. Kranz, Gerald D. Griffin and Milton L. Windler. Dr. Thomas O. Paine, Administrator, National Aeronautics and Space Administration, is seated at left. President Nixon was on the site to present the Presidential Medal of Freedom - the nation?s highest civilian honor -to the Apollo 13 Mission Operations Team.

  6. 13. Detail of vestibule, or main entrance, showing lamp and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Detail of vestibule, or main entrance, showing lamp and eastern set of doors. (Sept. 1991) The other sides of these doors are seen from the inside in WA-197-14. The 'ghosts' of ornamental wooden griffins can be seen above the doors. These griffins were stolen shortly after protective plywood doors were removed on Sept. 6, 1991 in preparation for the public auction on Sept. 10. At the time of the theft, the griffins had not yet been photographed. - Fox Theater, Seventh Avenue & Olive Way, Seattle, King County, WA

  7. Michael Young, the Institute of Community Studies, and the Politics of Kinship.

    PubMed

    Butler, Lise

    2015-01-01

    This article examines the East London-based Institute of Community Studies, and its founder, Michael Young, to show that sociology and social research offered avenues for left-wing political expression in the 1950s. Young, who had previously been Head of the Labour Party Research Department during the Attlee government, drew upon existing currents of psychological and sociological research to emphasize the continuing relevance of the extended family in industrial society and to offer a model of socialist citizenship, solidarity and mutual support not tied to productive work. Young and his colleagues at the Institute of Community Studies promoted the supportive kinship networks of the urban working class, and an idealized conception of the relationships between women, to suggest that family had been overlooked by the left and should be reclaimed as a progressive force. The article shows that the Institute's sociological work was informed by a pre-existing concern with family as a model for cooperative socialism, and suggests that sociology and social research should be seen as important sources of political commentary for scholars of post-war politics.

  8. Basic-functionalized recyclable ionic liquid catalyst: A solvent-free approach for Michael addition of 1,3-dicarbonyl compounds to nitroalkenes under ultrasound irradiation.

    PubMed

    Narayanaperumal, Senthil; da Silva, Rodrigo César; Feu, Karla Santos; de la Torre, Alexander Fernández; Corrêa, Arlene G; Paixão, Márcio Weber

    2013-05-01

    A task-specific ionic liquid (TSIL) has been introduced as a recyclable catalyst in Michael addition. A series of nitroalkenes and various C-based nucleophiles were reacted in the presence of 30mol% of recyclable basic-functionalized ionic liquid. Good to excellent yields were obtained in 30min under ultrasound irradiation. Copyright © 2012 Elsevier B.V. All rights reserved.

  9. How "The Right" Continues to "Do Wrong" by Our Young People: Contemporary Reflections on Michael Apple's Analysis of the "Rightist Turn" in Education

    ERIC Educational Resources Information Center

    McGregor, Glenda

    2018-01-01

    Michael Apple's 2005 article, "Doing Things the 'Right' Way: Legitimating Educational Inequalities in Conservative Times", is a seminal piece of writing that highlights some of his core concerns with the effects of neo-liberal and neo-conservative ideologies on education. Since its publication, this article has incited much debate about…

  10. β-Amino acid catalyzed asymmetric Michael additions: design of organocatalysts with catalytic acid/base dyad inspired by serine proteases.

    PubMed

    Yang, Hui; Wong, Ming Wah

    2011-09-16

    A new type of chiral β-amino acid catalyst has been computationally designed, mimicking the enzyme catalysis of serine proteases. Our catalyst approach is based on the bioinspired catalytic acid/base dyad, namely, a carboxyl and imidazole pair. DFT calculations predict that this designed organocatalyst catalyzes Michael additions of aldehydes to nitroalkenes with excellent enantioselectivities and remarkably high anti diastereoselectivities. The unusual stacked geometry of the enamine intermediate, hydrogen bonding network, and the adoption of an exo transition state are the keys to understand the stereoselectivity. © 2011 American Chemical Society

  11. The Use of Portfolios in Leadership Education

    ERIC Educational Resources Information Center

    Olsen, Paul E.

    2009-01-01

    This paper discusses the benefits of using student portfolios in undergraduate leadership education at Saint Michael's College. There appears to be a natural link between the use of portfolios as a tool to facilitate and document leadership growth and development. The Business Administration and Accounting Department at Saint Michael's College…

  12. 75 FR 5015 - Television Broadcasting Services; Oklahoma City, OK

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ...] Television Broadcasting Services; Oklahoma City, OK AGENCY: Federal Communications Commission. ACTION..., L.L.C. (``Griffin''), the licensee of KWTV-DT, channel 9, Oklahoma City, Oklahoma. Griffin requests the substitution of channel 39 for channel 9 at Oklahoma City. DATES: Comments must be filed on or...

  13. 76 FR 38179 - General Services Administration Acquisition Regulation; Information Collection; GSAR Provision...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... CONTACT: Mr. Michael Jackson, Procurement Analyst, Contract Policy Division, GSA, (202) 208-4949 or michaelo.jackson@gsa.gov . ADDRESSES: Submit comments identified by Information Collection 3090- 0197, GSAR...

  14. Hazardous Waste Cleanup: GPP-Florence, L.L.C. in Florence, New Jersey

    EPA Pesticide Factsheets

    Former Griffin Pipe Products Company is located at 1100 West Front Street in Florence, New Jersey. The 293-acre Griffin Pipe Products Company site has been operating as a foundry since the early 1900's, when it was known as the Florence Pipe and Foundry Co

  15. KSC-05PD-1535

    NASA Technical Reports Server (NTRS)

    2005-01-01

    KENNEDY SPACE CENTER, FLA. Against a sunrise-painted sky at NASA Kennedy Space Center, Miles OBrien (left), co-anchor on CNNs American Morning, talks on air with NASA Administrator Mike Griffin about the pending launch of Space Shuttle Discovery on the historic Return to Flight mission STS-114. It is the 114th Space Shuttle flight and the 31st for Discovery. The 12-day mission is expected to end with touchdown at the Shuttle Landing Facility at 11:06 a.m. July 25.

  16. KENNEDY SPACE CENTER, FLA. - At a luncheon during Space Congress Week, Michael Kostelnik, NASA deputy associate administrator for the Space Shuttle and the International Space Station, speaks to luncheon attendees about the future challenges the Agency faces. Held April 29-May 2, 2003, in Cape Canaveral, Fla., the Space Congress is an international conference that gathers attendees from the scientific community, the space industry workforce, educators and local supporting industries. This year's event commemorated the 40th anniversary of the Kennedy Space Center and the Centennial of Flight. The theme for the Space Congress was "Linking the Past to the Future: A Celebration of Space."

    NASA Image and Video Library

    2003-04-30

    KENNEDY SPACE CENTER, FLA. - At a luncheon during Space Congress Week, Michael Kostelnik, NASA deputy associate administrator for the Space Shuttle and the International Space Station, speaks to luncheon attendees about the future challenges the Agency faces. Held April 29-May 2, 2003, in Cape Canaveral, Fla., the Space Congress is an international conference that gathers attendees from the scientific community, the space industry workforce, educators and local supporting industries. This year's event commemorated the 40th anniversary of the Kennedy Space Center and the Centennial of Flight. The theme for the Space Congress was "Linking the Past to the Future: A Celebration of Space."

  17. Organocatalytic asymmetric anti-selective Michael reactions of aldehydes and the sequential reduction/lactonization/Pauson-Khand reaction for the enantioselective synthesis of highly functionalized hydropentalenes.

    PubMed

    Hong, Bor-Cherng; Dange, Nitin S; Yen, Po-Jen; Lee, Gene-Hsiang; Liao, Ju-Hsiou

    2012-10-19

    A new method has been developed for the enantioselective synthesis of highly functionalized hydropentalenes bearing up to four stereogenic centers with high stereoselectivity (up to 99% ee). This process combines an enantioselective organocatalytic anti-selective Michael addition with a highly efficient one-pot reduction/lactonization/Pauson-Khand reaction sequence. The structures and absolute configurations of the products were confirmed by X-ray analysis.

  18. 76 FR 21743 - General Services Administration Acquisition Regulation; Information Collection; Sealed Bidding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... comments on or before: June 17, 2011. FOR FURTHER INFORMATION CONTACT: Michael O. Jackson, Procurement Analyst, Contract Policy Branch, at telephone (202) 208-4949 or michaelo.jackson@gsa.gov . ADDRESSES...

  19. Mandibular angle augmentation with the use of distraction and homologous lyophilized cartilage in a case of morphing to Michael Jackson surgery.

    PubMed

    Mommaerts, M Y; Abeloos, J S; Gropp, H

    2001-08-01

    Correction of an ill-defined mandibular angle is not an easy task, whether it is requested by the "congenital, orthognathic or cosmetic" patient. Deliberate over-correction has not been reported to our knowledge. This article presents a combination of distraction osteogenesis and lyophilized cartilage used to three-dimensionally over-augment the mandibular angle of a long-face prognathic patient who had the wish to be morphed to Michael Jackson or at least as far as current technique and his endogenic features allowed.

  20. The Future of Professional Development Will Be Designed, Not Discovered: Response to Moon, Passmore, Reiser, and Michaels, "Beyond Comparisons of Online versus Face-to-Face PD"

    ERIC Educational Resources Information Center

    Fishman, Barry; Konstantopoulos, Spyros; Kubitskey, Beth W.; Vath, Richard; Park, Gina; Johnson, Heather; Edelson, Daniel

    2014-01-01

    This article represents a response to the authors' "Journal of Teacher Education" ("JTE") article (Fishman et al., 2013) by Moon, Passmore, Reiser, and Michaels (2013). The authors believe that Moon et al. have properly identified both the value in their study and the importance of moving beyond not only their study, but…

  1. What We Know about Adolescents' Out-of-School Literacies, What We Need to Learn, and Why Studying Them Is Important: An Interview with Michael W. Smith

    ERIC Educational Resources Information Center

    Smith, Michael W.; Moore, David W.

    2012-01-01

    Michael W. Smith, a professor in Temple University's College of Education, focuses his research on how experienced readers read and talk about texts as well as what motivates adolescents' reading and writing in and out of school. He sees the recent research on adolescents' out-of-school literacies as a challenge to literacy educators to look at…

  2. Optimization of the β-Elimination/Michael Addition Chemistry on Reversed-Phase Supports for Mass Spectrometry Analysis of O-Linked Protein Modifications

    PubMed Central

    Nika, Heinz; Nieves, Edward; Hawke, David H.; Angeletti, Ruth Hogue

    2013-01-01

    We previously adapted the β-elimination/Michael addition chemistry to solid-phase derivatization on reversed-phase supports, and demonstrated the utility of this reaction format to prepare phosphoseryl peptides in unfractionated protein digests for mass spectrometric identification and facile phosphorylation-site determination. Here, we have expanded the use of this technique to β-N-acetylglucosamine peptides, modified at serine/threonine, phosphothreonyl peptides, and phosphoseryl/phosphothreonyl peptides, followed in sequence by proline. The consecutive β-elimination with Michael addition was adapted to optimize the solid-phase reaction conditions for throughput and completeness of derivatization. The analyte remained intact during derivatization and was recovered efficiently from the silica-based, reversed-phase support with minimal sample loss. The general use of the solid-phase approach for enzymatic dephosphorylation was demonstrated with phosphoseryl and phosphothreonyl peptides and was used as an orthogonal method to confirm the identity of phosphopeptides in proteolytic mixtures. The solid-phase approach proved highly suitable to prepare substrates from low-level amounts of protein digests for phosphorylation-site determination by chemical-targeted proteolysis. The solid-phase protocol provides for a simple, robust, and efficient tool to prepare samples for phosphopeptide identification in MALDI mass maps of unfractionated protein digests, using standard equipment available in most biological laboratories. The use of a solid-phase analytical platform is expected to be readily expanded to prepare digest from O-glycosylated- and O-sulfonated proteins for mass spectrometry-based structural characterization. PMID:23997661

  3. Adam's Rage: Children of the Pinelands Speak: The Michael L. Printz Award Winning Novels: Authentic Current Literature as a Catalyst for Increased Student Growth, Motivation and Healing

    ERIC Educational Resources Information Center

    Cecchini, Stephanie Anne

    2012-01-01

    Young adults deserve our best as parents, educators and community members. The Michael L. Printz award winning books, instituted by the Young Adult Library Association, form a recent grouping of current literature. Novels worthy of the Printz Award explore physical, emotional, and social themes important in the lives of young adults. This library…

  4. Principles of Chemistry (by Michael Munowitz)

    NASA Astrophysics Data System (ADS)

    Kovac, Reviewed By Jeffrey

    2000-05-01

    At a time when almost all general chemistry textbooks seem to have become commodities designed by marketing departments to offend no one, it is refreshing to find a book with a unique perspective. Michael Munowitz has written what I can only describe as a delightful chemistry book, full of conceptual insight, that uses a novel and interesting pedagogic strategy. This is a book that has much to recommend it. This is the best-written general chemistry book I have ever read. An editor with whom I have worked recently remarked that he felt his job was to help authors make their writing sing. Well, the writing in Principles of Chemistry sings with the full, rich harmonies and creative inventiveness of the King's Singers or Chanticleer. Here is the first sentence of the introduction: "Central to any understanding of the physical world is one discovery of paramount importance, a truth disarmingly simple yet profound in its implications: matter is not continuous." This is prose to be savored and celebrated. Principles of Chemistry has a distinct perspective on chemistry: the perspective of the physical chemist. The focus is on simplicity, what is common about molecules and reactions; begin with the microscopic and build bridges to the macroscopic. The author's perspective is clear from the organization of the book. After three rather broad introductory chapters, there are four chapters that develop the quantum mechanical theory of atoms and molecules, including a strong treatment of molecular orbital theory. Unlike many books, Principles of Chemistry presents the molecular orbital approach first and introduces valence bond theory later only as an approximation for dealing with more complicated molecules. The usual chapters on descriptive inorganic chemistry are absent (though there is an excellent chapter on organic and biological molecules and reactions as well as one on transition metal complexes). Instead, descriptive chemistry is integrated into the development of

  5. STS-81 Crew at SLF with NASA Administrator Dan Goldin

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The STS-81 flight crew is welcomed to KSC by NASA Administrator Daniel Goldin (far right) and Johnson Space Center Director George Abbey (second from right) as they arrive at the space center for the final countdown preparations for the fifth Shuttle-Mir docking mission. They are (from left): Mission Commander Michael A. Baker; Pilot Brent W. Jett, Jr.; and Mission Specialists Peter J. K. 'Jeff' Wisoff; John M. Grunsfeld, Marsha S. Ivins, and J.M. 'Jerry' Linenger. The 10-day mission will feature the transfer of Linenger to Mir to replace astronaut John Blaha, who has been on the orbital laboratory since Sept. 19, 1996 after arrival there during the STS-79 mission. During STS- 81, Shuttle and Mir crews will conduct risk mitigation, human life science, microgravity and materials processing experiments that will provide data for the design, development and operation of the International Space Station. The primary payload is the SPACEHAB-DM double module will provide space for more than 2,000 pounds of hardware, food and water that will be transferred into the Russian space station during five days of docking operations. The SPACEHAB will also be used to return experiment samples from the Mir to Earth for analysis and for microgravity experiments during the mission.

  6. Use of Word Length Information in Utterance Planning

    ERIC Educational Resources Information Center

    Meyer, Antje S.; Belke, Eva; Hacker, Christine; Mortensen, Linda

    2007-01-01

    Griffin [Griffin, Z. M. (2003). "A reversed length effect in coordinating the preparation and articulation of words in speaking." "Psychonomic Bulletin & Review," 10, 603-609.] found that speakers naming object pairs spent more time before utterance onset looking at the second object when the first object name was short than when it was long. She…

  7. Crystallisation and preliminary X-ray diffraction analysis of the protease from Southampton norovirus complexed with a Michael-acceptor inhibitor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Coates, Leighton; Cooper, Jon; Hussey, Robert

    2008-01-01

    Noroviruses are the predominant cause of human epidemic nonbacterial gastroenteritis. Viral replication requires a cysteine protease that cleaves a 200 kDa viral polyprotein into its constituent functional parts. Here, the crystallization of the recombinant protease from the Southampton norovirus is described. While the native crystals were found to diffract only to medium resolution (2.9 {angstrom}), cocrystals of an inhibitor complex diffracted X-rays to 1.7 {angstrom} resolution. The polypeptide inhibitor (Ac-EFQLQ-propenyl ethyl ester) possesses an amino-acid sequence designed to match the substrate specificity of the enzyme, but was synthesized with a reactive Michael acceptor group at the C-terminal end.

  8. The economic role of the Emergency Department in the health care continuum: applying Michael Porter's five forces model to Emergency Medicine.

    PubMed

    Pines, Jesse M

    2006-05-01

    Emergency Medicine plays a vital role in the health care continuum in the United States. Michael Porters' five forces model of industry analysis provides an insight into the economics of emergency care by showing how the forces of supplier power, buyer power, threat of substitution, barriers to entry, and internal rivalry affect Emergency Medicine. Illustrating these relationships provides a view into the complexities of the emergency care industry and offers opportunities for Emergency Departments, groups of physicians, and the individual emergency physician to maximize the relationship with other market players.

  9. Young People Drawn to Aid in 2008 Race

    ERIC Educational Resources Information Center

    Klein, Alyson

    2008-01-01

    The scene in Brian Griffin's bedroom looks like a cross between a charity telethon and an intense cramming session the night before a final exam. Mr. Griffin and about 10 of his classmates--fellow members of the Plainfield High School (Indiana) chapter of Students for Barack Obama--are sprawled around the room, cellphones in hand, studying voter…

  10. STS-109 Astronaut Michael J. Massimino Peers Into Window of Shuttle During EVA

    NASA Technical Reports Server (NTRS)

    2002-01-01

    STS-109 Astronauts Michael J. Massimino and James H. Newman were making their second extravehicular activity (EVA) of their mission when astronaut Massimino, mission specialist, peered into Columbia's crew cabin during a brief break from work on the Hubble Space Telescope (HST). The HST is latched down just a few feet behind him in Columbia's cargo bay. The Space Shuttle Columbia STS-109 mission lifted off March 1, 2002 with goals of repairing and upgrading the Hubble Space Telescope (HST). STS-109 upgrades to the HST included: replacement of the solar array panels; replacement of the power control unit (PCU); replacement of the Faint Object Camera (FOC) with a new advanced camera for Surveys (ACS); and installation of the experimental cooling system for the Hubble's Near-Infrared Camera and Multi-object Spectrometer (NICMOS), which had been dormant since January 1999 when its original coolant ran out. The Marshall Space Flight Center in Huntsville, Alabama had the responsibility for the design, development, and construction of the HST, which is the most powerful and sophisticated telescope ever built. Lasting 10 days, 22 hours, and 11 minutes, the STS-109 mission was the 108th flight overall in NASA's Space Shuttle Program.

  11. Asymmetric organocatalyzed Michael addition of nitromethane to a 2-oxoindoline-3-ylidene acetaldehyde and the three one-pot sequential synthesis of (-)-horsfiline and (-)-coerulescine.

    PubMed

    Mukaiyama, Takasuke; Ogata, Kento; Sato, Itaru; Hayashi, Yujiro

    2014-10-13

    (-)-Horsfiline and (-)-coerulescine were synthesized through three one-pot operations in 33 and 46% overall yield, respectively. Key to the success was the efficient use of a diarylprolinol silyl ether to catalyze the asymmetric Michael addition of nitromethane to a 2-oxoindoline-3-ylidene acetaldehyde. This allowed the all-carbon quaternary, spirocyclic carbon stereocenter to be constructed in good yield with excellent enantioselectivity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. 76 FR 46808 - General Services Administration Acquisition Regulation; Submission for OMB Review; Sealed Bidding

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-03

    ... comments on or before: September 2, 2011. FOR FURTHER INFORMATION CONTACT: Michael O. Jackson, Procurement Analyst, Contract Policy Branch, at telephone (202) 208-4949 or michaelo.jackson@gsa.gov . ADDRESSES...

  13. Facile and Promising Method for Michael Addition of Indole and Pyrrole to Electron-Deficient trans-β-Nitroolefins Catalyzed by a Hydrogen Bond Donor Catalyst Feist's Acid and Preliminary Study of Antimicrobial Activity

    PubMed Central

    Al Majid, Abdullah M. A.; Islam, Mohammad Shahidul; Barakat, Assem; Al-Agamy, Mohamed H. M.; Naushad, Mu.

    2014-01-01

    The importance of cooperative hydrogen-bonding effects has been demonstrated using novel 3-methylenecyclopropane-1,2-dicarboxylic acid (Feist's acid (FA)) as hydrogen bond donor catalysts for the addition of indole and pyrrole to trans-β-nitrostyrene derivatives. Because of the hydrogen bond donor (HBD) ability, Feist's acid (FA) has been introduced as a new class of hydrogen bond donor catalysts for the activation of nitroolefin towards nucleophilic substitution reaction. It has effectively catalyzed the Michael addition of indoles and pyrrole to β-nitroolefins under optimum reaction condition to furnish the corresponding Michael adducts in good to excellent yields (up to 98%). The method is general, atom-economical, convenient, and eco-friendly and could provide excellent yields and regioselectivities. Some newly synthesized compounds were for examined in vitro antimicrobial activity and their preliminary results are reported. PMID:24574906

  14. ERIC: Sphinx or Golden Griffin?

    ERIC Educational Resources Information Center

    Lopez, Manuel D.

    1989-01-01

    Evaluates the Educational Resources Information Center (ERIC) database. Summarizes ERIC's history and organization, and discusses criticisms concerning access, currency, and database content. Reviews role of component clearinghouses, indexing practices, thesaurus structure, international coverage, and comparative studies. Finds ERIC a valuable…

  15. Successful treatment of facial systemic lupus erythematosus lesions with Dr Michaels® (Soratinex®) product family. A case report.

    PubMed

    Tirant, M; Bayer, P; Hercogovấ, J; Fioranelli, M; Gianfaldoni, S; Chokoeva, A A; Tchernev, G; Wollina, U; Novotny, F; Roccia, M G; Maximov, G K; França, K; Lotti, T

    2016-01-01

    Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain and other organs. We report the case of a 7-year-old female patient with facial lesions of SLE since the age of 5. There was no significant family history and patient had been a healthy child from birth. The child presented with a malar rash, also known as a butterfly rash, with distribution over the cheeks but sparing the nasal bridge. This case represents the efficacy of the Dr. Michaels® (Soratinex®) product family in the successful resolution of facial lesions of SLE.

  16. 75 FR 1788 - General Services Administration Regulation; Submission for OMB Review; Packing List Clause

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... INFORMATION CONTACT: Michael O. Jackson, Procurement Analyst, Contract Policy Branch, by telephone (202) 208-4949 or via e- mail at michaelo.jackson@gsa.gov . SUPPLEMENTARY INFORMATION: A. Purpose GSAR clause 552...

  17. 78 FR 1562 - Improving Government Regulations; Unified Agenda of Federal Regulatory and Deregulatory Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-08

    ... statutory administration requirements as required. Starting with the fall 2007 edition, the Internet became... Agenda database. Because publication in the Federal Register is mandated for the regulatory flexibility.... Michael L. Rhodes, Director, Administration and Management. Defense Acquisition Regulations Council...

  18. KENNEDY SPACE CENTER, FLA. - NASA's Associate Administrator for Space Flight William Readdy and Evelyn Husband, widow of astronaut Rick Husband, place a ceremonial wreath at the Space Mirror Memorial at the Kennedy Space Center Visitor Complex. During this dedication ceremony, the names of the STS-107 astronauts who lost their lives during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon -- join the names of 17 other space heroes who gave their lives for the U.S. space program. The "Space Mirror," 42 1/2 feet high by 50 feet wide, illuminates the names of the fallen astronauts cut through the monument's black granite surface.

    NASA Image and Video Library

    2003-10-28

    KENNEDY SPACE CENTER, FLA. - NASA's Associate Administrator for Space Flight William Readdy and Evelyn Husband, widow of astronaut Rick Husband, place a ceremonial wreath at the Space Mirror Memorial at the Kennedy Space Center Visitor Complex. During this dedication ceremony, the names of the STS-107 astronauts who lost their lives during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon -- join the names of 17 other space heroes who gave their lives for the U.S. space program. The "Space Mirror," 42 1/2 feet high by 50 feet wide, illuminates the names of the fallen astronauts cut through the monument's black granite surface.

  19. KENNEDY SPACE CENTER, FLA. - NASA's Associate Administrator for Space Flight William Readdy (left) and Evelyn Husband, widow of astronaut Rick Husband, place a ceremonial wreath at the Space Mirror Memorial at the Kennedy Space Center Visitor Complex. During this dedication ceremony, the names of the STS-107 astronauts who lost their lives during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon -- join the names of 17 other space heroes who gave their lives for the U.S. space program. The "Space Mirror," 42 1/2 feet high by 50 feet wide, illuminates the names of the fallen astronauts cut through the monument's black granite surface.

    NASA Image and Video Library

    2003-10-28

    KENNEDY SPACE CENTER, FLA. - NASA's Associate Administrator for Space Flight William Readdy (left) and Evelyn Husband, widow of astronaut Rick Husband, place a ceremonial wreath at the Space Mirror Memorial at the Kennedy Space Center Visitor Complex. During this dedication ceremony, the names of the STS-107 astronauts who lost their lives during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon -- join the names of 17 other space heroes who gave their lives for the U.S. space program. The "Space Mirror," 42 1/2 feet high by 50 feet wide, illuminates the names of the fallen astronauts cut through the monument's black granite surface.

  20. Black Administrators and Administrative Law

    ERIC Educational Resources Information Center

    Harper, Robert

    1975-01-01

    The stated objective of this paper is to keep the Black administrator out of court by creating an awareness of legal pitfalls: the discussion is divided into four sections--a brief overview of some of the functions of administrators and administrative agencies, sharing information with the public, the use of discretion, and limitations of the…

  1. Lewis acid-Lewis acid heterobimetallic cooperative catalysis: mechanistic studies and application in enantioselective aza-Michael reaction.

    PubMed

    Yamagiwa, Noriyuki; Qin, Hongbo; Matsunaga, Shigeki; Shibasaki, Masakatsu

    2005-09-28

    The full details of a catalytic asymmetric aza-Michael reaction of methoxylamine promoted by rare earth-alkali metal heterobimetallic complexes are described, demonstrating the effectiveness of Lewis acid-Lewis acid cooperative catalysis. First, enones were used as substrates, and the 1,4-adducts were obtained in good yield (57-98%) and high ee (81-96%). Catalyst loading was successfully reduced to 0.3-3 mol % with enones. To broaden the substrate scope of the reaction to carboxylic acid derivatives, alpha,beta-unsaturated N-acylpyrroles were used as monodentate, carboxylic acid derivatives. With beta-alkyl-substituted N-acylpyrroles, the reaction proceeded smoothly and the products were obtained in high yield and good ee. Transformation of the 1,4-adducts from enones and alpha,beta-unsaturated N-acylpyrroles afforded corresponding chiral aziridines and beta-amino acids. Detailed mechanistic studies, including kinetics, NMR analysis, nonlinear effects, and rare earth metal effects, are also described. The Lewis acid-Lewis acid cooperative mechanism, including the substrate coordination mode, is discussed in detail.

  2. Michael Jackson, Bin Laden and I: functions of positive and negative, public and private flashbulb memories.

    PubMed

    Demiray, Burcu; Freund, Alexandra M

    2015-01-01

    This study examined the perceived psychosocial functions of flashbulb memories: It compared positive and negative public flashbulb memories (positive: Bin Laden's death, negative: Michael Jackson's death) with private ones (positive: pregnancy, negative: death of a loved one). A sample of n = 389 young and n = 176 middle-aged adults answered canonical category questions used to identify flashbulb memories and rated the personal significance, the psychological temporal distance, and the functions of each memory (i.e., self-continuity, social-boding, directive functions). Hierarchical regressions showed that, in general, private memories were rated more functional than public memories. Positive and negative private memories were comparable in self-continuity and directionality, but the positive private memory more strongly served social functions. In line with the positivity bias in autobiographical memory, positive flashbulb memories felt psychologically closer than negative ones. Finally, middle-aged adults rated their memories as less functional regarding self-continuity and social-bonding than young adults. Results are discussed regarding the tripartite model of autobiographical memory functions.

  3. KSC-05PD-1761

    NASA Technical Reports Server (NTRS)

    2005-01-01

    KENNEDY SPACE CENTER, FLA. In the Launch Control Center at NASA Kennedy Space Center, NASA Administrator Mike Griffin (left) presents a gift to Columba Bush, wife of the Florida Governor Jeb Bush, to her left. First Lady Laura Bush, next to Griffin, is one of the distinguished guests who attended the historic launch of Space Shuttle Discovery on Return to Flight mission STS-114. At far left is Center Director Jim Kennedy. The First Lady congratulated the launch team for their success. On this mission to the International Space Station the crew will perform inspections on-orbit for the first time of all of the Reinforced Carbon-Carbon (RCC) panels on the leading edge of the wings and the Thermal Protection System tiles using the new Canadian-built Orbiter Boom Sensor System and the data from 176 impact and temperature sensors. Mission Specialists will also practice repair techniques on RCC and tile samples during a spacewalk in the payload bay. During two additional spacewalks, the crew will install the External Stowage Platform-2, equipped with spare part assemblies, and a replacement Control Moment Gyroscope contained in the Lightweight Multi-Purpose Experiment Support Structure. The 12-day mission is expected to end with touchdown at the Shuttle Landing Facility on Aug. 7.

  4. KSC-06pd1424

    NASA Image and Video Library

    2006-07-04

    KENNEDY SPACE CENTER, FLA. - In Firing Room 4 of the Launch Control Center, Shuttle Launch Director Mike Leinbach (center) is congratulated by NASA Administrator Mike Griffin (right) for the successful launch of Space Shuttle Discovery on mission STS-121. The launch was the first ever to take place on Independence Day. Behind Leinbach are David R. Mould, assistant administrator for Public Affairs NASA, and Lisa Malone, director of External Relations at Kennedy. Liftoff was on-time at 2:38 p.m. EDT. During the 12-day mission, the STS-121 crew of seven will test new equipment and procedures to improve shuttle safety, as well as deliver supplies and make repairs to the International Space Station. Landing is scheduled for July 16 or 17 at Kennedy's Shuttle Landing Facility. Photo credit: NASA/Kim Shiflett

  5. Heart Rate Variability in Patients Being Treated for Dengue Viral Infection: New Insights from Mathematical Correction of Heart Rate

    DTIC Science & Technology

    2014-02-25

    prognosis of viral infections, particu- larly in neonates and infants at risk of developing septic shock (Griffin and Moorman, 2001; Griffin et al...2004, 2005). In their studies, it was reported that abnormal HR with reduced variabil- ity and transient decelerations preceded neonatal /infant sepsis...hospital resuscitative treatment in DHF patients. After correction for prevailing HR, LF variability was still significantly increased (both P < 0.01) on day

  6. Enzyme-catalyzed Michael addition for the synthesis of warfarin and its determination via fluorescence quenching of L-tryptophan

    NASA Astrophysics Data System (ADS)

    Yuan, Yusheng; Yang, Liu; Liu, Shaopu; Yang, Jidong; Zhang, Hui; Yan, Jingjing; Hu, Xiaoli

    2017-04-01

    A sensitive fluorescence sensor for warfarin was proposed via quenching the fluorescence of L-tryptophan due to the interaction between warfarin and L-tryptophan. Warfarin, as one of the most effective anticoagulants, was designed and synthesized via lipase from porcine pancreas (PPL) as a biocatalyst to catalyze the Michael addition of 4-hydroxycoumarin to α, β-unsaturated enones in organic medium in the presence of water. Furthermore, the spectrofluorometry was used to detect the concentration of warfarin with a linear range and detection limit (3σ/k) of 0.04-12.0 μmol L- 1 (R2 = 0.994) and 0.01 μmol L- 1, respectively. Herein, this was the first application of bio-catalytic synthesis and fluorescence for the determination of warfarin. The proposed method was applied to determine warfarin of the drug in tablets with satisfactory results.

  7. Part 3. a novel stereocontrolled, in situ, solution- and solid-phase, Aza Michael approach for high-throughput generation of tetrahydroaminoquinoline-derived natural-product-like architectures.

    PubMed

    Prakesch, Michael; Srivastava, Stuti; Leek, Donald M; Arya, Prabhat

    2006-01-01

    With the goal of rapidly accessing tetrahydroquinoline-based natural-product-like polycyclic architectures, herein, we report an unprecedented, in situ, stereocontrolled Aza Michael approach in solution and on the solid phase. The mild reaction conditions required to reach the desired target are highly attractive for the use of this method in library generation. To our knowledge, this approach has not been used before, and it opens a novel route leading to a wide variety of tetrahydroquinoline-derived bridged tricyclic derivatives.

  8. Elemental Levels Analyzed by PIXE in Florida Alligators

    NASA Astrophysics Data System (ADS)

    Kuharik, J. C.; Kravchenko, I. I.; Dunnam, F. E.; Van Rinsvelt, H. A.; Ross, J. P.

    2003-08-01

    Unusual and alarming mortality of alligators (Alligator mississippiensis) has been reported from Lake Griffin, Florida, where almost 400 dead alligators have been observed since 1997. In addition, the hatch rate for alligator eggs around Lake Griffin fell below 10% and remains low (30-45%) while the normal hatch rate is typically 80%. Standard diagnostic methods have been ineffective in determining the cause of the phenomenon. Many possibilities have been considered including pollutants, nutrition, and toxic algae. Particle Induced X-ray Emission (PIXE) analysis is highly suitable for investigating concentrations of a wide range of elements in animal tissue. Liver, kidney and spinal cord tissues from healthy and sick alligators have been analyzed by PIXE for elemental content. Initial results showed positive correlation between certain elements and neural impairment and morbidity of alligators in Lake Griffin, but have failed to prove significant.

  9. Knowledge Is "a Form of Venture Capital" for a Top Columbia Administrator.

    ERIC Educational Resources Information Center

    Blumenstyk, Goldie

    2001-01-01

    Explains how for Michael M. Crow, executive vice provost at Columbia University, knowledge is a form of venture capital. This means pushing Columbia beyond the usual role of creating knowledge and disseminating it in traditional manners, and instead taking the knowledge, incubating it, and projecting it using tools like the Internet. (SM)

  10. Granulocyte-Macrophage Colony-Stimulating Factor: More Than a Hemopoietin

    DTIC Science & Technology

    1990-01-01

    Sullivan, R., Elias, A., Antman , K.. Schnipper, L.. and Griffin, D., Granulocyte-macrophage colony-stimulating factor induces the expression of the CDI lb...surface adhesion molecule on human granulocytes in vivo. Blood 72, 691--697, 1988. 38. Socinski, M. A., Cannistra, S., Elias, A., Antman , K. H...1989. 82. Antman , K.. Griffin, J., Elias, A., Socinski. M., Ryan, L., Cannistra, S., Gette, D., Whitly, M., Frei, E., and Schnipper, L., Effect of

  11. Racemic hemiacetals as oxygen-centered pronucleophiles triggering cascade 1,4-addition/Michael reaction through dynamic kinetic resolution under iminium catalysis. Development and mechanistic insights† †Electronic supplementary information (ESI) available: Detailed experimental procedures and characterization of all new compounds, including copies of NMR spectra and HPLC chromatograms traces, computational details and Cartesian coordinates of all stationary points. CCDC 1525188 (4l), 1525189 (6a) and 1525190 (9a). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00009j Click here for additional data file. Click here for additional data file.

    PubMed Central

    Orue, Ane; Uria, Uxue; Roca-López, David; Delso, Ignacio; Reyes, Efraím; Carrillo, Luisa

    2017-01-01

    2-Hydroxydihydropyran-5-ones behave as excellent polyfunctional reagents able to react with enals through oxa-Michael/Michael process cascade under the combination of iminium and enamine catalysis. These racemic hemiacetalic compounds are used as unconventional O-pronucleophiles in the initial oxa-Michael reaction, also leading to the formation of a single stereoisomer under a dynamic kinetic resolution (DKR) process. Importantly, by using β-aryl or β-alkyl substituted α,β-unsaturated substrates as initial Michael acceptors either kinetically or thermodynamically controlled diastereoisomers were formed with high stereoselection through the careful selection of the reaction conditions. Finally, a complete experimental and computational study confirmed the initially proposed DKR process during the catalytic oxa-Michael/Michael cascade reaction and also explained the kinetic/thermodynamic pathway operating in each case. PMID:28451356

  12. Reply to discussion by Michael A. Collins, "Fresh ground water stored in aquifers under the continental shelf: implications from a deep test, Nantucket Island, Massachusetts"

    USGS Publications Warehouse

    Kohout, F.A.; Delaney, D.F.

    1979-01-01

    We appreciate the comments made in the discussion by Michael A. Collins, regarding our paper about the anomalously low salinity of water underlying Nantucket Island. However, we feel that in his effort to justify the mathematical approach for solving salt water intrusion problems, he has overlooked several of the major points in this paper. We will try to amplify these points to establish that, indeed, the situation at Nantucket is anomalous, contrary to Collins’ negative conclusion (Collins, 1978).

  13. An unusual Michael-induced skeletal rearrangement of a bicyclo[3.3.1]nonane framework of phloroglucinols to a novel bioactive bicyclo[3.3.0]octane.

    PubMed

    Vidali, Veroniki P; Mitsopoulou, Kornilia P; Dakanali, Marianna; Demadis, Konstantinos D; Odysseos, Andreani D; Christou, Yiota A; Couladouros, Elias A

    2013-11-01

    A novel skeletal rearrangement of bicyclo[3.3.1]nonane-2,4,9-trione (16) to an unprecedented highly functionalized bicyclo[3.3.0]octane system (17), induced by an intramolecular Michael addition, is presented. This novel framework was found to be similarly active to hyperforin (1), against PC-3 cell lines. A mechanistic study was examined in detail, proposing a number of cascade transformations. Also, reactivity of the Δ(7,10)-double bond was examined under several conditions to explain the above results.

  14. Mother's love' for bacterial babies: the commitment of Audrey Michael, Mition Yoannes and Tilda Orami to medical research.

    PubMed

    Gibbs, Tammy; Vilakiva, Geraldine

    2013-01-01

    Audrey Michael, Mition Yoannes and Tilda Orami are long-term health researchers at the Papua New Guinea Institute of Medical Research (PNGIMR). Face-to-face interviews were conducted with all three women for the purpose of profiling women who are leaders in health and medicine in Papua New Guinea. They were asked questions about their early life and childhood, education, work life and training, and mentors who have supported their career path and leadership role. Audrey, Mition and Tilda have all made significant contributions to the PNGIMR and to the health of the people of PNG. In particular, all three have been part of pneumococcal conjugate vaccine (PCV) studies--looking at the safety, immunogenicity and priming for immunological memory of a 7-valent PCV and investigating the safety and immune responses to two different, recently licensed types of PCV, a 13-valent and a 10-valent vaccine.

  15. Learning from New York City : a case study of public health policy practice in the Bloomberg administration.

    PubMed

    Isett, Kimberley Roussin; Laugesen, Miriam J; Cloud, David H

    2015-01-01

    To ascertain any lessons learned about how public health reforms undertaken in New York City during the Bloomberg Administration were shepherded through the public policy and administration gauntlet. The question is, how feasible is this approach and would it work outside of New York City? Using a theoretically grounded case study approach, 3 initiatives were examined that were proposed and/or implemented during a 10-year period of the Mayoralty of Michael Bloomberg (2002-2011): transfats restrictions, clean bus transportation policies, and a sugar-sweetened beverages tax (as a counterfactual). The investigation began by performing a comprehensive public documents search and was followed with interviews of 27 individuals involved in the selected policy initiatives. Interviews were coded in Nvivo using an iterative, grounded methodology. Using a theoretical lens, the case study illustrates that the multifaceted role of leadership was not confined to the executives in the City or the Agency. Instead, leadership extended to other administrative officials within the agency and the Board of Health. Second, New York City used reorganization and coordinative mechanisms strategically to ensure achievement of their goals. This included creation of new departments/bureaus and coordinating structures across the City. Evidence of the explicit use of incentives, as initially anticipated from the theoretical framework, was not found. While some aspects of this case study are unique to the context of New York City, 2 approaches used in New York City are feasible for other jurisdictions: harnessing the full scope and breadth of authority of the agency and its associated boards and commissions, and remobilizing existing workforce to explicitly focus on and coordinate targeted policies for issues of concern. Questions for further consideration are posed at the conclusion of the article.

  16. Educational Administration and the Social, Policy, and Administrative Sciences.

    ERIC Educational Resources Information Center

    Kirkpatrick, Samuel A.

    1983-01-01

    The politics of education has been ignored in educational administration programs; it has been not enough taught in American programs for educational administrators and not enough emphasized in discussions of administrative roles. Administration increasingly includes political as well as rational decisions. Thus, administrators need a unified…

  17. Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

    PubMed

    Freedy, Allyson M; Matos, Maria J; Boutureira, Omar; Corzana, Francisco; Guerreiro, Ana; Akkapeddi, Padma; Somovilla, Víctor J; Rodrigues, Tiago; Nicholls, Karl; Xie, Bangwen; Jiménez-Osés, Gonzalo; Brindle, Kevin M; Neves, André A; Bernardes, Gonçalo J L

    2017-12-20

    Chemical modification of proteins is essential for a variety of important diagnostic and therapeutic applications. Many strategies developed to date lack chemo- and regioselectivity as well as result in non-native linkages that may suffer from instability in vivo and adversely affect the protein's structure and function. We describe here the reaction of N-nucleophiles with the amino acid dehydroalanine (Dha) in a protein context. When Dha is chemically installed in proteins, the addition of a wide-range N-nucleophiles enables the rapid formation of amine linkages (secondary and tertiary) in a chemoselective manner under mild, biocompatible conditions. These new linkages are stable at a wide range of pH values (pH 2.8 to 12.8), under reducing conditions (biological thiols such as glutathione) and in human plasma. This method is demonstrated for three proteins and is shown to be fully compatible with disulfide bridges, as evidenced by the selective modification of recombinant albumin that displays 17 structurally relevant disulfides. The practicability and utility of our approach is further demonstrated by the construction of a chemically modified C2A domain of Synaptotagmin-I protein that retains its ability to preferentially bind to apoptotic cells at a level comparable to the native protein. Importantly, the method was useful for building a homogeneous antibody-drug conjugate with a precise drug-to-antibody ratio of 2. The kinase inhibitor crizotinib was directly conjugated to Dha through its piperidine motif, and its antibody-mediated intracellular delivery results in 10-fold improvement of its cancer cell-killing efficacy. The simplicity and exquisite site-selectivity of the aza-Michael ligation described herein allows the construction of stable secondary and tertiary amine-linked protein conjugates without affecting the structure and function of biologically relevant proteins.

  18. View of activity in Mission Control Center during Apollo 15 EVA

    NASA Image and Video Library

    1971-08-02

    S71-41852 (2 Aug. 1971) --- Gerald D. Griffin, foreground, stands near his console in the Mission Operations Control Room (MOCR) during Apollo 15's third extravehicular activity (EVA) on the lunar surface. Griffin is Gold Team (Shift 1) flight director for the Apollo 15 mission. Astronauts David R. Scott and James B. Irwin can be seen on the large screen at the front of the MOCR as they participate in sample-gathering on the lunar surface.

  19. Flow-Induced Oscillations of OTEC Mooring and Anchoring Cables: State of the Art.

    DTIC Science & Technology

    1982-05-27

    general, including heat exchangers , overhead transmission lines, and marine structures and cables. A flowchart that describes the steps necessary to...34Crossflow-Induced Vibrations of Heat Exchanger Tube Banks," Nuc. Engrg. and Design, Vol. 47, 67-86, 1978. 22. O.M. Griffin and S.E. Ramberg, "On...AD-AIlS 462 NAVAL RESEARCH LAB WASHINGTON DC F/6 13/13 FLOW-INOUCED OSCILLATIONS OF OTEC MOORING AND ANCHORING CABLES --ETC(UI MAY 62 0 M GRIFFIN

  20. KSC-06pd1489

    NASA Image and Video Library

    2006-07-04

    KENNEDY SPACE CENTER, FLA. - From Firing Room 4 of the Launch Control Center, NASA Administrator Mike Griffin uses binoculars to view of the launch of Space Shuttle Discovery (in the background) on mission STS-121. The launch made history as the first to occur on Independence Day. Liftoff was on-time at 2:38 p.m. EDT. During the 12-day mission, the STS-121 crew of seven will test new equipment and procedures to improve shuttle safety, as well as deliver supplies and make repairs to the International Space Station. Landing is scheduled for July 16 or 17 at Kennedy's Shuttle Landing Facility. Photo credit: NASA/Bill Ingalls

  1. KSC-06pd1583

    NASA Image and Video Library

    2006-07-17

    KENNEDY SPACE CENTER, FLA. - During the traditional post-flight walk-around after the landing of an orbiter, NASA Administrator Mike Griffin (right) shares a story with STS-121 Pilot Mark Kelly, Mission Specialist Lisa Nowak and Commander Steven Lindsey. Discovery's smooth and perfect landing was on time at 9:14 a.m. EDT on Runway 15 of NASA's Shuttle Landing Facility after traveling 5.3 million miles on 202 orbits. Mission elapsed time was 12 days, 18 hours, 37 minutes and 54 seconds. The landing is the 62nd at Kennedy Space Center and the 32nd for Discovery. Photo credit: NASA/Kim Shiflett

  2. KENNEDY SPACE CENTER, FLA. -- Sandra Anderson, wife of STS-107 Payload Commander Michael Anderson, visits a new residence hall at the Florida Institute of Technology (FIT) in Melbourne, Fla., named for her late husband. Family members of the STS-107 astronauts, other dignitaries, members of the university community and the public gathered for a dedication ceremony for the Columbia Village at FIT. Each of the seven new residence halls in the complex is named for one of the STS-107 astronauts who perished during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon.

    NASA Image and Video Library

    2003-10-28

    KENNEDY SPACE CENTER, FLA. -- Sandra Anderson, wife of STS-107 Payload Commander Michael Anderson, visits a new residence hall at the Florida Institute of Technology (FIT) in Melbourne, Fla., named for her late husband. Family members of the STS-107 astronauts, other dignitaries, members of the university community and the public gathered for a dedication ceremony for the Columbia Village at FIT. Each of the seven new residence halls in the complex is named for one of the STS-107 astronauts who perished during the Columbia accident -- Rick Husband, Willie McCool, Laurel Clark, Michael Anderson, David Brown, Kalpana Chawla, and Ilan Ramon.

  3. Gizzard shad thiaminase activity and its effect on the thiamine status of captive American alligators Alligator mississippiensis.

    PubMed

    Ross, J Perran; Honeyfield, Dale C; Brown, Scott B; Brown, Lisa R; Waddle, Amanda Rice; Welker, Michael E; Schoeb, Trenton R

    2009-12-01

    Adult mortality and low egg hatch rate were observed among American alligators Alligator mississippiensis in Lake Griffin, Florida, between 1998 and 2003. Previous studies show that the alligator mortality is due to neurological impairment associated with thiamine (vitamin Bt) deficiency. This study determined the rate of thiaminase activity in gizzard shad Dorosoma cepedianum, a fish often eaten by alligators, and examined the thiamine status of captive adult alligators fed only gizzard shad. We found that the thiaminase activity of gizzard shad in Lake Griffin is 16,409 +/- 2,121 pmol/g/min (mean +/- 2SEs). This high rate of thiaminase activity was present in most months and across a wide range of shad sizes. Seven alligators were captured in the wild from Lake Griffin and Lake Woodruff, held in captivity, and fed gizzard shad. We monitored blood and muscle thiamine levels throughout the experiment and liver thiamine at the end. Over a period of 6-12 months, all of the alligators maintained weight but blood and muscle thiamine levels decreased to 25-50% of the original (healthy) values. Three animals with the greatest reduction in thiamine died, demonstrating mobility impairment and neural histopathology similar to those seen in wild alligators in Lake Griffin. Two alligators were fed shad for 10 months but then treated with thiamine. These animals showed a reduction in thiamine while eating shad, but treatment restored their thiamine levels to the initial values, which were comparable to those of normal wild Lake Griffin alligators. We demonstrated that thiamine deficiency can be induced by a diet of gizzard shad and cause neurological signs and death in alligators in captivity. We conclude that the thiaminase activity in gizzard shad is high enough to cause thiamine deficiency in wild alligators when shad are a major part of their diet.

  4. Ideas on Policy toward Latin America for the New Administration

    DTIC Science & Technology

    2009-03-24

    better use our resources. For example, it might be useful to consider the success of some microcredit programs in developing areas such as India for...but might need some refinement. Glenwick reports that 18 microcredit is effective, but cannot be relied upon to lift significant numbers of people out...Trade_Agreements/Bilateral_Investment_Treaties/index.asp (accessed December 17, 2008). 42 Michael Glenwick, "Is Microcredit the Answer or an Answer for

  5. In the Hot Seat: STS-115 Lightning Strike Stand Down Debate - NASA Case Study

    NASA Technical Reports Server (NTRS)

    Kummer, Lizette; Stevens, Jennifer

    2016-01-01

    There is no way the PIC's could have seen any current' was the gist of Mike Griffin's assessment. Griffin was the NASA Administrator at the time. The buck stopped at his desk. Holding a napkin out to Pat Lampton, Griffin showed Lampton the calculations he'd made over dinner that predicted that the Pyrotechnic Initiator Controllers (PIC's) at the base of the Space Shuttle Solid Rocket Boosters (SRBs) were fine. A lightning strike the day before, the worst ever experienced with a Space Shuttle on the launch pad, caused a halt to the launch count down as technicians, engineers, and managers scrambled identify any damage to the launch system. SRB technicians and engineers assessed the data against their Lightning Strike Re-Test Requirements, determining that all but one of the requirements could be checked if they resumed the countdown. For the one remaining requirement, testing the integrity of the PIC's would require 96 hours to set up, test, and reassemble. The engineers were convinced that there was no way to do calculations to show the PIC's were okay. The only option was to stand down. It was SRB Deputy Project Manager (PM) Pat Lampton's responsibility to decide what the SRB project position needed to be to certify that their hardware was safe to fly. He had to communicate that decision to the Mission Management Team (MMT) as a Go or No Go position to resume the count down. If the answer was Go they could still meet a delayed, but acceptable launch schedule. If the answer was No Go, rescheduling the launch would be a grueling shuffling of hardware, personnel, and mission timelines to accommodate Russian missions to the Space Station, supplies for the launch, and personnel manning launch operations. On top of that, Hurricane Ernesto was spinning off the coast of Florida, threatening the need for the Shuttle to roll back to the hangar if they waited too long.

  6. STS-6 MISSION OPERATIONS CONTROL ROOM (MOCR) ACTIVITIES - DAY 5 - JSC

    NASA Image and Video Library

    1983-04-09

    Various views of STS-6 MOCR activities during Day-5 with Vice-Pres. George Bush, Cap Communicator Bridges, JSC Director Gerald Griffin, Eugene F. Kranz, NASA Admin. James M. Beggs, Cap Com Astronaut O'Connor, Flight Directors Jay H. Greene, Gary E. Coen, and Harold Draughon. 1. BUSH, GEORGE, VICE-PRES. - STS-6 MOCR 2. DIR. GRIFFIN, GERALD D. - STS-6 MOCR 3. ADMIN. BEGGS, JAMES M. - STS-6 MOCR 4. FLT. DIRECTORS - STS-6 JSC, HOUSTON, TX Also available in 35 CN

  7. [Expectations of hospital administrators about administrative functions of nurses].

    PubMed

    Melo, M R; Fávero, N; Trevizan, M A; Hayashida, M

    1996-01-01

    The objective of the present study was to investigate hospital administrator's expectations about the administrative role played by nurses, utilizing functions proposed by the Neoclassical Theory of Administration: planning, organization, direction, and control as theoretical references. An instrument established in TREVIZAN (1989) was applied to 11 hospital administrators. The results showed they expect the four functions to be done by nurses. Therefore, the interaction between nurses and hospital administrators is critical to improve the patient's assistance.

  8. Solid State Ionics: from Michael Faraday to green energy-the European dimension.

    PubMed

    Funke, Klaus

    2013-08-01

    Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag 2 S and PbF 2 and coined terms such as cation and anion , electrode and electrolyte . In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic) transport in ionic crystals became easy to visualize. In an 'evolving scheme of materials science', point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals), by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987.

  9. Solid State Ionics: from Michael Faraday to green energy—the European dimension

    PubMed Central

    Funke, Klaus

    2013-01-01

    Solid State Ionics has its roots essentially in Europe. First foundations were laid by Michael Faraday who discovered the solid electrolytes Ag2S and PbF2 and coined terms such as cation and anion, electrode and electrolyte. In the 19th and early 20th centuries, the main lines of development toward Solid State Ionics, pursued in Europe, concerned the linear laws of transport, structural analysis, disorder and entropy and the electrochemical storage and conversion of energy. Fundamental contributions were then made by Walther Nernst, who derived the Nernst equation and detected ionic conduction in heterovalently doped zirconia, which he utilized in his Nernst lamp. Another big step forward was the discovery of the extraordinary properties of alpha silver iodide in 1914. In the late 1920s and early 1930s, the concept of point defects was established by Yakov Il'ich Frenkel, Walter Schottky and Carl Wagner, including the development of point-defect thermodynamics by Schottky and Wagner. In terms of point defects, ionic (and electronic) transport in ionic crystals became easy to visualize. In an ‘evolving scheme of materials science’, point disorder precedes structural disorder, as displayed by the AgI-type solid electrolytes (and other ionic crystals), by ion-conducting glasses, polymer electrolytes and nano-composites. During the last few decades, much progress has been made in finding and investigating novel solid electrolytes and in using them for the preservation of our environment, in particular in advanced solid state battery systems, fuel cells and sensors. Since 1972, international conferences have been held in the field of Solid State Ionics, and the International Society for Solid State Ionics was founded at one of them, held at Garmisch-Partenkirchen, Germany, in 1987. PMID:27877585

  10. Administrative Training: What Really Prepares Administrators for the Job?

    ERIC Educational Resources Information Center

    Kraus, Christine M.

    This paper describes part of a study (Kraus 1996) involving 25 school administrators who attended one of five administrator preparation programs at four New England universities. The study addressed research questions regarding perceptions of administrators' job preparedness and how components of formal training programs (i.e., internships,…

  11. Merging the Military Health System (MHS) and the Veterans Health Administration (VHA) into a Single Governance Structure

    DTIC Science & Technology

    2008-04-07

    3 Testimony of Dr. Michael J. Kussman , Acting Undersecretary for Health, Department of Veterans Affairs, U.S. House of Representatives, Subcommittee...J. Kussman , March 8, 2007. 49 Testimony of the Honorable Patrick W. Dunne, October 17, 2007. 50 U.S. Congressional Budget Office, The Healthcare

  12. Barratt on middeck

    NASA Image and Video Library

    2011-02-25

    S133-E-006027 (25 Feb. 2011) --- Astronaut Michael Barratt, STS-133 mission specialist, works out on the bicycle ergometer on Discovery's middeck during flight day 2 activities. Photo credit: NASA or National Aeronautics and Space Administration

  13. Humans to Mars Summit 2014

    NASA Image and Video Library

    2014-04-22

    Miles O'Brien, science correspondant for PBS NewsHour, left, leads a panel discussion on Mars exploration with William Gerstenmaier, NASA Associatate Administrator for Human Explorations and Operations, center, and Michael Gazarik, NASA Associate Administrator for Space Technology, left, at the Humans to Mars Summit on April 22, 2014 at George Washington University in Washington, DC. Photo Credit: (NASA/Joel Kowsky)

  14. Administrative Woman and Administrative Man: Teaching Public Administration from a Gender Inclusive Perspective.

    ERIC Educational Resources Information Center

    Burnier, DeLysa

    1992-01-01

    Asserts that courses in public administration provide special challenges for feminist instructors because men and women do not always have the same career opportunities or experiences. Describes the content and teaching procedures of a Principles of Public Administration course designed to consider women's issues. (CFR)

  15. Administrative Synergy

    ERIC Educational Resources Information Center

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  16. Michael Addition Reactions between Chiral Equivalents of a Nucleophilic Glycine and (S)- or (R)-3-[(E)-Enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a General Method for Efficient Preparation of β-Substituted Pyroglutamic Acids. Case of Topographically Controlled Stereoselectivity

    PubMed Central

    Soloshonok*, Vadim A.; Cai, Chaozhong; Yamada, Takeshi; Ueki, Hisanori; Ohfune, Yasufumi; Hruby, Victor J.

    2006-01-01

    This paper describes a systematic study of addition reactions between the chiral Ni(II) complex of the Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general and synthetically efficient approach to β-substituted pyroglutamic acids and relevant compounds. These reactions were shown to occur at room temperature in the presence of nonchelating organic bases and, most notably, with very high (>98% diastereomeric excess (de)) stereoselectivity at both newly formed stereogenic centers. The stereochemical outcome of the reactions was found to be overwhelmingly controlled by the stereochemical preferences of the Michael acceptors, and the chirality of the glycine complex influenced only the reaction rate. Thus, in the reactions of both the (S)-configured Ni(II) complex and the Michael acceptors, the reaction rates were exceptionally high, allowing preparation of the corresponding products with virtually quantitative (>98%) chemical and stereochemical yields. In contrast, reactions of the (S)-configured Ni(II) complex and (R)-configured Michael acceptors proceeded at noticeably lower rates, but the addition products were obtained in high diastereo-and enantiomeric purity. To rationalize the remarkably high and robust stereoselectivity observed in these reactions, we consider an enzyme–substrate-like mode of interaction involing a topographical match or mismatch of two geometric figures. Excellent chemical and stereochemical yields, combined with the simplicity and operational convenience of the experimental procedures, render the present method of immediate use for preparing various β-substituted pyroglutamic acids and related compounds. PMID:16248672

  17. Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity.

    PubMed

    Soloshonok, Vadim A; Cai, Chaozhong; Yamada, Takeshi; Ueki, Hisanori; Ohfune, Yasufumi; Hruby, Victor J

    2005-11-02

    This paper describes a systematic study of addition reactions between the chiral Ni(II) complex of the Schiff base of glycine with (S)-o-[N-(N-benzylprolyl)amino]benzophenone and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general and synthetically efficient approach to beta-substituted pyroglutamic acids and relevant compounds. These reactions were shown to occur at room temperature in the presence of nonchelating organic bases and, most notably, with very high (>98% diastereomeric excess (de)) stereoselectivity at both newly formed stereogenic centers. The stereochemical outcome of the reactions was found to be overwhelmingly controlled by the stereochemical preferences of the Michael acceptors, and the chirality of the glycine complex influenced only the reaction rate. Thus, in the reactions of both the (S)-configured Ni(II) complex and the Michael acceptors, the reaction rates were exceptionally high, allowing preparation of the corresponding products with virtually quantitative (>98%) chemical and stereochemical yields. In contrast, reactions of the (S)-configured Ni(II) complex and (R)-configured Michael acceptors proceeded at noticeably lower rates, but the addition products were obtained in high diastereo- and enantiomeric purity. To rationalize the remarkably high and robust stereoselectivity observed in these reactions, we consider an enzyme-substrate-like mode of interaction involving a topographical match or mismatch of two geometric figures. Excellent chemical and stereochemical yields, combined with the simplicity and operational convenience of the experimental procedures, render the present method of immediate use for preparing various beta-substituted pyroglutamic acids and related compounds.

  18. Pathology, physiologic parameters, tissue contaminants, and tissue thiamine in morbid and healthy central Florida adult American alligators (Alligator mississippiensis)

    USGS Publications Warehouse

    Honeyfield, D.C.; Ross, J.P.; Carbonneau, D.A.; Terrell, S.P.; Woodward, A.R.; Schoeb, T.R.; Perceval, H.F.; Hinterkopf, J.P.

    2008-01-01

    An investigation of adult alligator (Alligator mississippiensis) mortalities in Lake Griffin, central Florida, was conducted from 1998-2004. Alligator mortality was highest in the months of April and May and annual death count peaked in 2000. Bacterial pathogens, heavy metals, and pesticides were not linked with the mortalities. Blood chemistry did not point to any clinical diagnosis, although differences between impaired and normal animals were noted. Captured alligators with signs of neurologic impairment displayed unresponsive and uncoordinated behavior. Three of 21 impaired Lake Griffin alligators were found to have neural lesions characteristic of thiamine deficiency in the telencephalon, particularly the dorsal ventricular ridge. In some cases, lesions were found in the thalamus, and parts of the midbrain. Liver and muscle tissue concentrations of thiamine (vitamin B"1) were lowest in impaired Lake Griffin alligators when compared to unimpaired alligators or to alligators from Lake Woodruff. The consumption of thiaminase-positive gizzard shad (Dorosoma cepedianum) is thought to have been the cause of the low tissue thiamine and resulting mortalities. ?? Wildlife Disease Association 2008.

  19. A Logic for Inclusion of Administrative Domains and Administrators in Multi-domain Authorization

    NASA Astrophysics Data System (ADS)

    Iranmanesh, Zeinab; Amini, Morteza; Jalili, Rasool

    Authorization policies for an administrative domain or a composition of multiple domains in multi-domain environments are determined by either one administrator or multiple administrators' cooperation. Several logic-based models for multi-domain environments' authorization have been proposed; however, they have not considered administrators and administrative domains in policies' representation. In this paper, we propose the syntax, proof theory, and semantics of a logic for multi-domain authorization policies including administrators and administrative domains. Considering administrators in policies provides the possibility of presenting composite administration having applicability in many collaborative applications. Indeed, administrators and administrative domains stated in policies can be used in authorization. The presented logic is based on modal logic and utilizes two calculi named the calculus of administrative domains and the calculus of administrators. It is also proved that the logic is sound. A case study is presented signifying the logic application in practical projects.

  20. 78 FR 30861 - Membership of the Office of the Secretary Performance Review Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ... Officer and Assistant Secretary for Administration Frederick E. Stephens, Deputy Assistant Secretary for... T. Alston, Director, Financial Reporting and Internal Controls Michael E. Phelps, Director, Office of Budget Lisa Casias, Director for Financial Management and Deputy Chief Financial Officer Office of...

  1. Abortion foe convicted and sentenced for murders of women's health clinic workers.

    PubMed

    1996-03-22

    On March 18, after deliberating for approximately nine hours over two days, a Dedham, Massachusetts, jury found John Salvi guilty of two counts of first-degree murder for the December 1994 shooting deaths of Shannon Lowney and Lee Ann Nichols, receptionists at two Brookline, Massachusetts, women's health care clinics. Salvi was also convicted of five counts of assault with intent to murder (see RFN IV/1). Almost immediately, Norfolk Superior Court Judge Barbara Dortch-Okara ordered Salvi to serve the maximum sentence--two consecutive life terms in prison without parole--for the murders and an additional 90-100 years for the five assaults. Under Massachusetts law, the first-degree murder convictions will be automatically appealed. In reaching their verdict, the jury of six men and six women rejected Salvi's plea of not guilty by reason of insanity. The five-week trial included testimony from more than 100 witnesses. In the past two years, two other men have been convicted for the first-degree murders of abortion providers: Michael Griffin, who was convicted of murdering Dr. David Gunn in March 1994, is now serving a life sentence; and Paul Hill, who was convicted of murdering Dr. John Britton and James Barrett in November 1995, is on Florida's death row while his sentence is pending mandatory appeal (see RFN III/19, 22). full text

  2. Neil Armstrong Family Memorial Service

    NASA Image and Video Library

    2012-08-31

    Apollo 11 Astronauts Michael Collins, left, NASA Deputy Administrator Lori Garver and NASA Administrator Charles Bolden, right, talk at a private memorial service celebrating the life of Neil Armstrong, Aug. 31, 2012, at the Camargo Club in Cincinnati. Armstrong, the first man to walk on the moon during the 1969 Apollo 11 mission, died Saturday, Aug. 25. He was 82. Photo Credit: (NASA/Bill Ingalls)

  3. Impact of an electronic medication administration record on medication administration efficiency and errors.

    PubMed

    McComas, Jeffery; Riingen, Michelle; Chae Kim, Son

    2014-12-01

    The study aims were to evaluate the impact of electronic medication administration record implementation on medication administration efficiency and occurrence of medication errors as well as to identify the predictors of medication administration efficiency in an acute care setting. A prospective, observational study utilizing time-and-motion technique was conducted before and after electronic medication administration record implementation in November 2011. A total of 156 cases of medication administration activities (78 pre- and 78 post-electronic medication administration record) involving 38 nurses were observed at the point of care. A separate retrospective review of the hospital Midas+ medication error database was also performed to collect the rates and origin of medication errors for 6 months before and after electronic medication administration record implementation. The mean medication administration time actually increased from 11.3 to 14.4 minutes post-electronic medication administration record (P = .039). In a multivariate analysis, electronic medication administration record was not a predictor of medication administration time, but the distractions/interruptions during medication administration process were significant predictors. The mean hospital-wide medication errors significantly decreased from 11.0 to 5.3 events per month post-electronic medication administration record (P = .034). Although no improvement in medication administration efficiency was observed, electronic medication administration record improved the quality of care with a significant decrease in medication errors.

  4. Dual-stream accounts bridge the gap between monkey audition and human language processing. Comment on "Towards a Computational Comparative Neuroprimatology: Framing the language-ready brain" by Michael Arbib

    NASA Astrophysics Data System (ADS)

    Garrod, Simon; Pickering, Martin J.

    2016-03-01

    Over the last few years there has been a resurgence of interest in dual-stream dorsal-ventral accounts of language processing [4]. This has led to recent attempts to bridge the gap between the neurobiology of primate audition and human language processing with the dorsal auditory stream assumed to underlie time-dependent (and syntactic) processing and the ventral to underlie some form of time-independent (and semantic) analysis of the auditory input [3,10]. Michael Arbib [1] considers these developments in relation to his earlier Mirror System Hypothesis about the origins of human language processing [11].

  5. STS-134 crew during food tasting session in JSC Food Lab.

    NASA Image and Video Library

    2010-05-25

    JSC2010-E-087707 (25 May 2010) --- NASA astronaut Michael Fincke, STS-134 mission specialist, participates in a food tasting session in the Habitability and Environmental Factors Office at NASA's Johnson Space Center. Photo credit: NASA or National Aeronautics and Space Administration

  6. Barratt in U.S. Laboratory

    NASA Image and Video Library

    2011-03-03

    S133-E-008328 (3 March 2011) --- NASA astronaut Michael Barratt, STS-133 mission specialist, works in the Destiny laboratory of the International Space Station while space shuttle Discovery remains docked with the station. Photo credit: NASA or National Aeronautics and Space Administration

  7. Barratt on Middeck with camera

    NASA Image and Video Library

    2011-02-28

    S133-E-007943 (28 Feb. 2011) --- NASA astronaut Michael Barratt, STS-133 mission specialist, uses a still camera on the middeck of space shuttle Discovery while docked with the International Space Station. Photo credit: NASA or National Aeronautics and Space Administration

  8. Barratt in Cupola

    NASA Image and Video Library

    2011-02-28

    S133-E-007236 (27 Feb. 2011) --- NASA astronaut Michael Barratt, STS-133 mission specialist, is pictured in the Cupola of the International Space Station while space shuttle Discovery remains docked with the station. Photo credit: NASA or National Aeronautics and Space Administration

  9. Barratt in Cupola

    NASA Image and Video Library

    2011-03-01

    S133-E-007475 (1 March 2011) --- NASA astronaut Michael Barratt, STS-133 mission specialist, is pictured in the Cupola of the International Space Station while space shuttle Discovery remains docked with the station. Photo credit: NASA or National Aeronautics and Space Administration

  10. Barratt in U.S. Laboratory

    NASA Image and Video Library

    2011-03-03

    S133-E-008327 (3 March 2011) --- NASA astronaut Michael Barratt, STS-133 mission specialist, works in the Destiny laboratory of the International Space Station while space shuttle Discovery remains docked with the station. Photo credit: NASA or National Aeronautics and Space Administration

  11. 76 FR 58262 - Notice of Proposed Restricted Service List or Section 106 Consultation; Boott Hydropower Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ... that, to eliminate unnecessary expense or improve administrative efficiency, the Secretary may... for the proposed license amendment. For purposes of completing the section 106 process, we propose to... Facility Trust, One Tech Drive, Suite 220, Andover, MA 01810. Michael Creasey, Superintendent. National...

  12. System administrator`s guide to CDPS. Version 1.0

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Didier, B.T.; Portwood, M.H.

    The System Administrator`s Guide to CDPS is intended for those responsible for setting up and maintaining the hardware and software of a Common Mapping Standard (CMS) Date Production System (CDPS) installation. This guide assists the system administrator in performing typical administrative functions. It is not intended to replace the Ultrix Documentation Set that should be available for a DCPS installation. The Ultrix Documentation Set will be required to provide details on referenced Ultrix commands as well as procedures for performing Ultrix maintenance functions. There are six major sections in this guide. Section 1 introduces the system administrator to CDPS andmore » describes the assumptions that are made by this guide. Section 2 describes the CDPS platform configuration. Section 3 describes the platform preparation that is required to install the CDPS software. Section 4 describes the CPS software and its installation procedures. Section 5 describes the CDS software and its installation procedures. Section 6 describes various operation and maintenance procedures. Four appendices are also provided. Appendix A contains a list of used acronyms. Appendix B provides a terse description of common Ultrix commands that are used in administrative functions. Appendix C provides sample CPS and CDS configuration files. Appendix D provides a required list and a recommended list of Ultrix software subsets for installation on a CDPS platform.« less

  13. Polyphosphoester-Camptothecin Prodrug with Reduction-Response Prepared via Michael Addition Polymerization and Click Reaction.

    PubMed

    Du, Xueqiong; Sun, Yue; Zhang, Mingzu; He, Jinlin; Ni, Peihong

    2017-04-26

    Polyphosphoesters (PPEs), as potential candidates for biocompatible and biodegradable polymers, play an important role in material science. Various synthetic methods have been employed in the preparation of PPEs such as polycondensation, polyaddition, ring-opening polymerization, and olefin metathesis polymerization. In this study, a series of linear PPEs has been prepared via one-step Michael addition polymerization. Subsequently, camptothecin (CPT) derivatives containing disulfide bonds and azido groups were linked onto the side chain of the PPE through Cu(I)-catalyzed azidealkyne cyclo-addition "click" chemistry to yield a reduction-responsive polymeric prodrug P(EAEP-PPA)-g-ss-CPT. The chemical structures were characterized by nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared, ultraviolet-visible spectrophotometer, and high performance liquid chromatograph analyses, respectively. The amphiphilic prodrug could self-assemble into micelles in aqueous solution. The average particle size and morphology of the prodrug micelles were measured by dynamic light scattering and transmission electron microscopy, respectively. The results of size change under different conditions indicate that the micelles possess a favorable stability in physiological conditions and can be degraded in reductive medium. Moreover, the studies of in vitro drug release behavior confirm the reduction-responsive degradation of the prodrug micelles. A methyl thiazolyl tetrazolium assay verifies the good biocompatibility of P(EAEP-PPA) not only for normal cells, but also for tumor cells. The results of cytotoxicity and the intracellular uptake about prodrug micelles further demonstrate that the prodrug micelles can efficiently release CPT into 4T1 or HepG2 cells to inhibit the cell proliferation. All these results show that the polyphosphoester-based prodrug can be used for triggered drug delivery system in cancer treatment.

  14. Administrative Attribution Theory.

    ERIC Educational Resources Information Center

    Frasher, James M.; Frasher, Ramona S.

    1981-01-01

    Hypothesizes that the growing body of empirical data concerning attribution theory offers insight into the administrative process. To stimulate research to test this hypothesis, presents previous relevant research and a theory entitled Administrative Attribution Theory. Research questions applying the theory to educational administration are…

  15. Teachers' and Administrators' Perceptions of Knowledge Management Competence of High School Administrators

    ERIC Educational Resources Information Center

    Memisoglu, Salih Pasa

    2016-01-01

    This study aims to determine the teachers' and administrators' perceptions of knowledge management competence in high school administration. The study was conducted using the screening model and the study group consisted of 162 teachers and 35 administrators working at eight high schools in Turkey. Administrators' knowledge management competence…

  16. 33 CFR 116.30 - Administrator, Bridge Administration Program Review and Evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Administrator, Bridge..., DEPARTMENT OF HOMELAND SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.30 Administrator, Bridge Administration Program Review and Evaluation. (a) Upon receiving a Detailed Investigation Report...

  17. NASA Education Stakeholder's Summit

    NASA Image and Video Library

    2010-09-12

    Special Assitant for STEM Education, U. S. Department of Education, Michael Lach, far right, addresses guests at the NASA Education Stakeholders’ Summit One Stop Shopping Initiative (OSSI), Monday, Sep. 13, 2010, at the Westfields Marriott Conference Center in Chantilly, VA. Seated from right are James Stofan, NASA Acting Associate Administrator for Education; Charles Bolden, NASA Administrator; and Cora B. Marrett, Acting Director, National Science Foundation. (Photo Credit: NASA/Carla Cioffi)

  18. School Business Administration.

    ERIC Educational Resources Information Center

    Jordan, K. Forbis; And Others

    This textbook reviews the principal concerns within each of 13 major responsibility areas in school business administration. The first chapter assesses the political, social, and economic context in which schools function and school administrators work. The role and function of the school business administrator within this context is addressed in…

  19. A stale challenge to the philosophy of science: commentary on "Is psychology based on a methodological error?" by Michael Schwarz.

    PubMed

    Ruck, Nora; Slunecko, Thomas

    2010-06-01

    In his article "Is psychology based on a methodological error?" and based on a quite convincing empirical basis, Michael Schwarz offers a methodological critique of one of mainstream psychology's key test theoretical axioms, i.e., that of the in principle normal distribution of personality variables. It is characteristic of this paper--and at first seems to be a strength of it--that the author positions his critique within a frame of philosophy of science, particularly positioning himself in the tradition of Karl Popper's critical rationalism. When scrutinizing Schwarz's arguments, however, we find Schwarz's critique profound only as an immanent critique of test theoretical axioms. We raise doubts, however, as to Schwarz's alleged 'challenge' to the philosophy of science because the author not at all seems to be in touch with the state of the art of contemporary philosophy of science. Above all, we question the universalist undercurrent that Schwarz's 'bio-psycho-social model' of human judgment boils down to. In contrast to such position, we close our commentary with a plea for a context- and culture sensitive philosophy of science.

  20. Administrative Ecology

    ERIC Educational Resources Information Center

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…