Science.gov

Sample records for admission control mechanism

  1. An Improved Call Admission Control Mechanism with Prioritized Handoff Queuing Scheme for BWA Networks

    NASA Astrophysics Data System (ADS)

    Chowdhury, Prasun; Saha Misra, Iti

    2014-10-01

    Nowadays, due to increased demand for using the Broadband Wireless Access (BWA) networks in a satisfactory manner a promised Quality of Service (QoS) is required to manage the seamless transmission of the heterogeneous handoff calls. To this end, this paper proposes an improved Call Admission Control (CAC) mechanism with prioritized handoff queuing scheme that aims to reduce dropping probability of handoff calls. Handoff calls are queued when no bandwidth is available even after the allowable bandwidth degradation of the ongoing calls and get admitted into the network when an ongoing call is terminated with a higher priority than the newly originated call. An analytical Markov model for the proposed CAC mechanism is developed to analyze various performance parameters. Analytical results show that our proposed CAC with handoff queuing scheme prioritizes the handoff calls effectively and reduces dropping probability of the system by 78.57% for real-time traffic without degrading the number of failed new call attempts. This results in the increased bandwidth utilization of the network.

  2. SARS: hospital infection control and admission strategies.

    PubMed

    Ho, Pak-Leung; Tang, Xiao-Ping; Seto, Wing-Hong

    2003-11-01

    Nosocomial clustering with transmission to health care workers, patients and visitors is a prominent feature of severe acute respiratory syndrome (SARS). Hospital outbreaks of SARS typically occurred within the first week after admission of the very first SARS cases when the disease was not recognized and before isolation measures were implemented. In the majority of nosocomial infections, there was a history of close contact with a SARS patient, and transmission occurred via large droplets, direct contact with infectious material or by contact with fomites contaminated by infectious material. In a few instances, potential airborne transmission was reported in association with endotracheal intubation, nebulised medications and non-invasive positive pressure ventilation of SARS patients. In all SARS-affected countries, nosocomial transmission of the disease was effectively halted by enforcement of routine standard, contact and droplet precautions in all clinical areas and additional airborne precautions in the high-risk areas. In Hong Kong, where there are few private rooms for patient isolation, some hospitals have obtained good outcome by having designated SARS teams and separate wards for patient triage, confirmed SARS cases and step-down of patients in whom SARS had been ruled out. In conclusion, SARS represents one of the new challenges for those who are involved in hospital infection control. As SARS might re-emerge, all hospitals should take advantage of the current SARS-free interval to review their infection control programmes, alert mechanisms, response capability and to repair any identified inadequacies.

  3. 28 CFR 541.47 - Admission to control unit.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Admission to control unit. 541.47 Section 541.47 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Control Unit Programs § 541.47 Admission to control...

  4. 28 CFR 541.47 - Admission to control unit.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Admission to control unit. 541.47 Section 541.47 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Control Unit Programs § 541.47 Admission to control...

  5. 28 CFR 541.47 - Admission to control unit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Admission to control unit. 541.47 Section 541.47 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Control Unit Programs § 541.47 Admission to control...

  6. 28 CFR 541.47 - Admission to control unit.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Admission to control unit. 541.47 Section 541.47 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT INMATE DISCIPLINE AND SPECIAL HOUSING UNITS Control Unit Programs § 541.47 Admission to control...

  7. A lexicographic approach to constrained MDP admission control

    NASA Astrophysics Data System (ADS)

    Panfili, Martina; Pietrabissa, Antonio; Oddi, Guido; Suraci, Vincenzo

    2016-02-01

    This paper proposes a reinforcement learning-based lexicographic approach to the call admission control problem in communication networks. The admission control problem is modelled as a multi-constrained Markov decision process. To overcome the problems of the standard approaches to the solution of constrained Markov decision processes, based on the linear programming formulation or on a Lagrangian approach, a multi-constraint lexicographic approach is defined, and an online implementation based on reinforcement learning techniques is proposed. Simulations validate the proposed approach.

  8. A self-learning call admission control scheme for CDMA cellular networks.

    PubMed

    Liu, Derong; Zhang, Yi; Zhang, Huaguang

    2005-09-01

    In the present paper, a call admission control scheme that can learn from the network environment and user behavior is developed for code division multiple access (CDMA) cellular networks that handle both voice and data services. The idea is built upon a novel learning control architecture with only a single module instead of two or three modules in adaptive critic designs (ACDs). The use of adaptive critic approach for call admission control in wireless cellular networks is new. The call admission controller can perform learning in real-time as well as in offline environments and the controller improves its performance as it gains more experience. Another important contribution in the present work is the choice of utility function for the present self-learning control approach which makes the present learning process much more efficient than existing learning control methods. The performance of our algorithm will be shown through computer simulation and compared with existing algorithms. PMID:16252828

  9. 49 CFR 382.121 - Employee admission of alcohol and controlled substances use.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... completion of an educational or treatment program, as determined by a drug and alcohol abuse evaluation... 49 Transportation 5 2011-10-01 2011-10-01 false Employee admission of alcohol and controlled... SAFETY REGULATIONS CONTROLLED SUBSTANCES AND ALCOHOL USE AND TESTING General § 382.121 Employee...

  10. 49 CFR 382.121 - Employee admission of alcohol and controlled substances use.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... completion of an educational or treatment program, as determined by a drug and alcohol abuse evaluation... 49 Transportation 5 2010-10-01 2010-10-01 false Employee admission of alcohol and controlled... SAFETY REGULATIONS CONTROLLED SUBSTANCES AND ALCOHOL USE AND TESTING General § 382.121 Employee...

  11. 28 CFR 541.47 - Admission to control unit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the inmate's confinement in a control unit; (b) Notice of the type of personal property which is allowable in the unit (items made of glass or metal will not be permitted); (c) A summary of the...

  12. Reduced Admissions for Acute Myocardial Infarction Associated with a Public Smoking Ban: Matched Controlled Study

    ERIC Educational Resources Information Center

    Seo, Dong-Chul; Torabi, Mohammad R.

    2007-01-01

    There has been no research linking implementation of a public smoking ban and reduced incidence of acute myocardial infarction (AMI) among nonsmoking patients. An ex post facto matched control group study was conducted to determine whether there was a change in hospital admissions for AMI among nonsmoking patients after a public smoking ban was…

  13. Mechanical versus clinical data combination in selection and admissions decisions: a meta-analysis.

    PubMed

    Kuncel, Nathan R; Klieger, David M; Connelly, Brian S; Ones, Deniz S

    2013-11-01

    In employee selection and academic admission decisions, holistic (clinical) data combination methods continue to be relied upon and preferred by practitioners in our field. This meta-analysis examined and compared the relative predictive power of mechanical methods versus holistic methods in predicting multiple work (advancement, supervisory ratings of performance, and training performance) and academic (grade point average) criteria. There was consistent and substantial loss of validity when data were combined holistically-even by experts who are knowledgeable about the jobs and organizations in question-across multiple criteria in work and academic settings. In predicting job performance, the difference between the validity of mechanical and holistic data combination methods translated into an improvement in prediction of more than 50%. Implications for evidence-based practice are discussed. PMID:24041118

  14. HYDRAULIC SERVO CONTROL MECHANISM

    DOEpatents

    Hussey, R.B.; Gottsche, M.J. Jr.

    1963-09-17

    A hydraulic servo control mechanism of compact construction and low fluid requirements is described. The mechanism consists of a main hydraulic piston, comprising the drive output, which is connected mechanically for feedback purposes to a servo control piston. A control sleeve having control slots for the system encloses the servo piston, which acts to cover or uncover the slots as a means of controlling the operation of the system. This operation permits only a small amount of fluid to regulate the operation of the mechanism, which, as a result, is compact and relatively light. This mechanism is particuiarly adaptable to the drive and control of control rods in nuclear reactors. (auth)

  15. Effect of air pollution control on mortality and hospital admissions in Ireland.

    PubMed

    Dockery, Douglas W; Rich, David Q; Goodman, Patrick G; Clancy, Luke; Ohman-Strickland, Pamela; George, Prethibha; Kotlov, Tania

    2013-07-01

    and 1998 bans, adjusting for influenza epidemics, weekly mean temperature, and local admissions for digestive diagnoses. Mean BS concentrations fell in all affected population centers post-ban compared with the pre-ban period, with decreases ranging from 4 to 35 microg/m3 (corresponding to reductions of 45% to 70%, respectively), but we observed no clear pattern in SO2 measured as total gaseous acidity associated with the bans. In comparisons with the pre-ban periods, no significant reduction was found in total death rates associated with the 1990 (1% reduction), 1995 (4% reduction), or 1998 (0% reduction) bans, nor for cardiovascular mortality (0%, 4%, and 1% reductions for the 1990, 1995, and 1998 bans, respectively). Respiratory mortality was reduced in association with the bans (17%, 9%, and 3%, respectively). We found a 4% decrease in hospital admissions for cardiovascular disease associated with the 1995 ban and a 3% decrease with the 1998 ban. Admissions for respiratory disease were not consistently lower after the bans; admissions for pneumonia, chronic obstructive pulmonary disease (COPD), and asthma were reduced. However, underreporting of hospital admissions data and lack of control and comparison series tempered our confidence in these results. The successive coal bans resulted in immediate and sustained decreases in particulate concentrations in each city or town; with the largest decreases in winter and during the heating season. The bans were associated with reductions in respiratory mortality but no detectable improvement in cardiovascular mortality. The changes in hospital admissions for respiratory and cardiovascular disease were supportive of these findings but cannot be considered confirming. Detecting changes in public health indicators associated even with clear improvements in air quality, as in this case, remains difficult when there are simultaneous secular improvements in the same health indicators.

  16. Admissions Policies as a Mechanism for Social Engineering: The Case of the Bulgarian Communist Regime

    ERIC Educational Resources Information Center

    Boyadjieva, Pepka Alexandrova

    2013-01-01

    This article discusses admissions policies to higher education during the Communist regime in Bulgaria (1946-89). It argues that under the conditions of the Bulgarian Communist regime, admissions policies were not only a component of the higher education system--viewed as an institution--but part and parcel of the process through which power was…

  17. Mitigating Handoff Call Dropping in Wireless Cellular Networks: A Call Admission Control Technique

    NASA Astrophysics Data System (ADS)

    Ekpenyong, Moses Effiong; Udoh, Victoria Idia; Bassey, Udoma James

    2016-06-01

    Handoff management has been an important but challenging issue in the field of wireless communication. It seeks to maintain seamless connectivity of mobile users changing their points of attachment from one base station to another. This paper derives a call admission control model and establishes an optimal step-size coefficient (k) that regulates the admission probability of handoff calls. An operational CDMA network carrier was investigated through the analysis of empirical data collected over a period of 1 month, to verify the performance of the network. Our findings revealed that approximately 23 % of calls in the existing system were lost, while 40 % of the calls (on the average) were successfully admitted. A simulation of the proposed model was then carried out under ideal network conditions to study the relationship between the various network parameters and validate our claim. Simulation results showed that increasing the step-size coefficient degrades the network performance. Even at optimum step-size (k), the network could still be compromised in the presence of severe network crises, but our model was able to recover from these problems and still functions normally.

  18. Heterogeneous voice flows-oriented call admission control in IEEE 802.11e WLANs

    NASA Astrophysics Data System (ADS)

    Wu, Qi-lin; Huang, Zhen-jin; Wang, Shi-yi

    2014-04-01

    Considering the circumstance of heterogeneous voice flows, first, by applying Markov chain, this paper proposes an unsaturated analytical model for the IEEE 802.11e EDCA protocol, which considers the condition of non-ideal transmission channel and the character of the occurrence of backoff countdown at the beginning of time slot in EDCA protocol. Furthermore, according to the proposed model, the media access delay and throughput of a flow are analysed, and the flow-oriented call admission control (CAC) scheme is proposed. Finally, the simulation results are shown to confirm that the proposed CAC scheme can guarantee the requirements of throughput and delay of voice flows, and can admit more voice flows to improve the utilisation efficiency of network resources by choosing the appropriate values of the minimum contention window or the appropriate varieties of voice flows.

  19. Adaptive call admission control and resource allocation in multi server wireless/cellular network

    NASA Astrophysics Data System (ADS)

    Jain, Madhu; Mittal, Ragini

    2016-11-01

    The ever increasing demand of the subscribers has put pressure on the capacity of wireless networks around the world. To utilize the scare resources, in the present paper we propose an optimal allocation scheme for an integrated wireless/cellular model with handoff priority and handoff guarantee services. The suggested algorithm optimally allocates the resources in each cell and dynamically adjust threshold to control the admission. To give the priority to handoff calls over the new calls, the provision of guard channels and subrating scheme is taken into consideration. The handoff voice call may balk and renege from the system while waiting in the buffer. An iterative algorithm is implemented to generate the arrival rate of the handoff calls in each cell. Various performance indices are established in term of steady state probabilities. The sensitivity analysis has also been carried out to examine the tractability of algorithms and to explore the effects of system descriptors on the performance indices.

  20. Call admission control for CDMA systems with Interference Guard Margin (IGM)

    NASA Astrophysics Data System (ADS)

    Chen, Huan; Kumar, Sunil; Kuo, C.-C. Jay

    2002-01-01

    A call admission control (CAC) scheme and a resource-reservation estimation (RRE) method suitable for the interference-based wireless system, such as wide-band code division multiple access (W-CDMA), are proposed in this work. The proposed CAC scheme gives preferential treatment to high priority handoff calls by pre-reserving a certain amount of interference margin called the interference guard margin (IGM). The amount of guard margin is determined by the measurement performed by the RRE module in base stations. Each RRE module dynamically adjusts the level of guard margin by considering traffic conditions in neighboring cells based upon handoff requests. A service model is adopted to support multiple services, which includes mobile terminal's data rate, different levels of priorities, mobility and rate adaptivity characteristics. Simulations are conducted with OPNET to study the performance of the proposed scheme in terms of the objective function, blocking probabilities and system utilization under different traffic conditions.

  1. REACTOR CONTROL MECHANISM

    DOEpatents

    Lane, J.A.; Engberg, R.E.; Welch, J.M.

    1959-05-12

    A quick-releasing mechanism is described which may be used to rapidiy drop a device supported from beneath during normal use, such as a safety rod in a nuclear reactor. In accordance with this invention an electrical control signal, such as may be provided by radiation detection or other alarm condition sensing devices, is delivered to an electromagnetic solenoid, the armature of which is coupled to an actuating mechanism. The solenoid is energized when the mechanism is in its upper or cocked position. In such position, the mechanism engages a plurality of retaining balls, forcing them outward into engagement with a shoulder or recess in a corresponding section of a tubular extension on the upheld device. When the control signal to the solenoid suddenly ceases, the armature drops out, allowing the actuating mechanism to move slightly but rapidly under the force of a compressed spring. The weight of the device will urge the balls inward against a beveled portion of the actuating mechanism and away from the engaging section on the tubular extension, thus allowing the upheld device to fall freely under the influence of gravity.

  2. Admission Control Over Internet of Vehicles Attached With Medical Sensors for Ubiquitous Healthcare Applications.

    PubMed

    Lin, Di; Labeau, Fabrice; Yao, Yuanzhe; Vasilakos, Athanasios V; Tang, Yu

    2016-07-01

    Wireless technologies and vehicle-mounted or wearable medical sensors are pervasive to support ubiquitous healthcare applications. However, a critical issue of using wireless communications under a healthcare scenario rests at the electromagnetic interference (EMI) caused by radio frequency transmission. A high level of EMI may lead to a critical malfunction of medical sensors, and in such a scenario, a few users who are not transmitting emergency data could be required to reduce their transmit power or even temporarily disconnect from the network in order to guarantee the normal operation of medical sensors as well as the transmission of emergency data. In this paper, we propose a joint power and admission control algorithm to schedule the users' transmission of medical data. The objective of this algorithm is to minimize the number of users who are forced to disconnect from the network while keeping the EMI on medical sensors at an acceptable level. We show that a fixed point of proposed algorithm always exists, and at the fixed point, our proposed algorithm can minimize the number of low-priority users who are required to disconnect from the network. Numerical results illustrate that the proposed algorithm can achieve robust performance against the variations of mobile hospital environments. PMID:25974956

  3. Mechanical control of airplanes

    NASA Technical Reports Server (NTRS)

    Boykow, H

    1929-01-01

    Before undertaking a detailed description of an automatic-control mechanism, I will state briefly the fundamental conditions for such devices. These are: 1) it must be sensitive at one or more reference values; 2) it must stop the angular motions of the airplane not produced by the pilot; and 3) it must be possible to switch it off and on by a simple hand lever.

  4. Medical-Grade Channel Access and Admission Control in 802.11e EDCA for Healthcare Applications

    PubMed Central

    Son, Sunghwa; Park, Kyung-Joon; Park, Eun-Chan

    2016-01-01

    In this paper, we deal with the problem of assuring medical-grade quality of service (QoS) for real-time medical applications in wireless healthcare systems based on IEEE 802.11e. Firstly, we show that the differentiated channel access of IEEE 802.11e cannot effectively assure medical-grade QoS because of priority inversion. To resolve this problem, we propose an efficient channel access algorithm. The proposed algorithm adjusts arbitrary inter-frame space (AIFS) in the IEEE 802.11e protocol depending on the QoS measurement of medical traffic, to provide differentiated near-absolute priority for medical traffic. In addition, based on rigorous capacity analysis, we propose an admission control scheme that can avoid performance degradation due to network overload. Via extensive simulations, we show that the proposed mechanism strictly assures the medical-grade QoS and improves the throughput of low-priority traffic by more than several times compared to the conventional IEEE 802.11e. PMID:27490666

  5. Medical-Grade Channel Access and Admission Control in 802.11e EDCA for Healthcare Applications.

    PubMed

    Son, Sunghwa; Park, Kyung-Joon; Park, Eun-Chan

    2016-01-01

    In this paper, we deal with the problem of assuring medical-grade quality of service (QoS) for real-time medical applications in wireless healthcare systems based on IEEE 802.11e. Firstly, we show that the differentiated channel access of IEEE 802.11e cannot effectively assure medical-grade QoS because of priority inversion. To resolve this problem, we propose an efficient channel access algorithm. The proposed algorithm adjusts arbitrary inter-frame space (AIFS) in the IEEE 802.11e protocol depending on the QoS measurement of medical traffic, to provide differentiated near-absolute priority for medical traffic. In addition, based on rigorous capacity analysis, we propose an admission control scheme that can avoid performance degradation due to network overload. Via extensive simulations, we show that the proposed mechanism strictly assures the medical-grade QoS and improves the throughput of low-priority traffic by more than several times compared to the conventional IEEE 802.11e. PMID:27490666

  6. Shocking Admission

    ERIC Educational Resources Information Center

    Hoover, Eric; Millman, Sierra

    2007-01-01

    Marilee Jones's career had been a remarkable success. She joined Massachusetts Institute of Technology's (MIT's) admissions office in 1979, landing a job in Cambridge at a time when boys ruled the sandbox of the admissions profession. Her job was to help MIT recruit more women, who then made up less than one-fifth of the institute's students. She…

  7. Patient-controlled hospital admission for patients with severe mental disorders: study protocol for a nationwide prospective multicentre study

    PubMed Central

    Thomsen, Christoffer Torgaard; Benros, Michael Eriksen; Hastrup, Lene Halling; Andersen, Per Kragh; Giacco, Domenico; Nordentoft, Merete

    2016-01-01

    Introduction Patient-controlled hospital admission for individuals with severe mental disorders is a novel approach in mental healthcare. Patients can admit themselves to a hospital unit for a short stay without being assessed by a psychiatrist or contacting the emergency department. Previous studies assessing the outcomes of patient-controlled hospital admission found trends towards reduction in the use of coercive measures and length of hospital stay; however, these studies have methodological shortcomings and small sample sizes. Larger studies are needed to estimate the effect of patient-controlled hospital admission on the use of coercion and of healthcare services. Design and methods We aim to recruit at least 315 patients who are offered a contract for patient-controlled hospital admissions in eight different hospitals in Denmark. Patients will be followed-up for at least 1 year to compare the use of coercive measures and of healthcare services, the use of medications and suicidal behaviour. Descriptive statistics will be used to investigate hospitalisations, global assessment of functioning (GAF) and patient satisfaction with treatment. To minimise selection bias, we will match individuals using patient-controlled hospital admission and controls with a 1:5 ratio via a propensity score based on the following factors: sex, age group, primary diagnosis, substance abuse as secondary diagnosis, coercion, number of psychiatric bed days, psychiatric history, urbanity and suicidal behaviour. Additionally, a historical control study will be undertaken in which patients serve as their own control group prior to index date. Ethics and dissemination The study has been approved by The Danish Health and Medicines Authority (j.nr.: 3-3013-934/1/) and by The Danish Data Protection Agency (j.nr.: 2012-58-0004). The study was categorised as a register study by The Danish Health Research Ethics Committee and therefore no further approval was needed (j.nr.: H-2-2014-FSP70

  8. Admissions Testing & Institutional Admissions Processes

    ERIC Educational Resources Information Center

    Hossler, Don; Kalsbeek, David

    2009-01-01

    The array of admissions models and the underlying, and sometimes conflicting goals people have for college admissions, create the dynamics and the tensions that define the contemporary context for enrollment management. The senior enrollment officer must ask, for example, how does an institution try to assure transparency, equality of access,…

  9. Gear shift control mechanism

    SciTech Connect

    Janson, D.A.

    1987-03-10

    A gear shift control mechanism is described comprising: multiple shift rods directed substantially parallel to one another, each rod carrying a shift fork for axial movement; a shift lever supported for pivotal movement about a first axis directed parallel to the axes of the shift rods and for pivotal movement about a second axis directed substantially perpendicular to the axes of the shift rods. The lever is moveable about the first axis and the second axis into engagement with a selected shift fork; interlock means located on each lateral side of the shift lever and mounted for pivotal movement about the first axis for blocking engagement with the shift forks; detent means for holding the shift lever in multiple predetermined angular positions about the second axis; and spring means located on a lateral side of the shift lever and mounted for pivotal movement about the first axis into interference contact with the shift forks for producing a force tending to resiliently bias the shift lever out of engagement with the selected shift fork.

  10. Relationship between glycated hemoglobin, Intensive Care Unit admission blood sugar and glucose control with ICU mortality in critically ill patients

    PubMed Central

    Mahmoodpoor, Ata; Hamishehkar, Hadi; Shadvar, Kamran; Beigmohammadi, Mohammadtaghi; Iranpour, Afshin; Sanaie, Sarvin

    2016-01-01

    Background and Aims: The association between hyperglycemia and mortality is believed to be influenced by the presence of diabetes mellitus (DM). In this study, we evaluated the effect of preexisting hyperglycemia on the association between acute blood glucose management and mortality in critically ill patients. The primary objective of the study was the relationship between HbA1c and mortality in critically ill patients. Secondary objectives of the study were relationship between Intensive Care Unit (ICU) admission blood glucose and glucose control during ICU stay with mortality in critically ill patients. Materials and Methods: Five hundred patients admitted to two ICUs were enrolled. Blood sugar and hemoglobin A1c (HbA1c) concentrations on ICU admission were measured. Age, sex, history of DM, comorbidities, Acute Physiology and Chronic Health Evaluation II score, sequential organ failure assessment score, hypoglycemic episodes, drug history, mortality, and development of acute kidney injury and liver failure were noted for all patients. Results: Without considering the history of diabetes, nonsurvivors had significantly higher HbA1c values compared to survivors (7.25 ± 1.87 vs. 6.05 ± 1.22, respectively, P < 0.001). Blood glucose levels in ICU admission showed a significant correlation with risk of death (P < 0.006, confidence interval [CI]: 1.004–1.02, relative risk [RR]: 1.01). Logistic regression analysis revealed that HbA1c increased the risk of death; with each increase in HbA1c level, the risk of death doubled. However, this relationship was not statistically significant (P: 0.161, CI: 0.933–1.58, RR: 1.2). Conclusions: Acute hyperglycemia significantly affects mortality in the critically ill patients; this relation is also influenced by chronic hyperglycemia. PMID:27076705

  11. Brain Mechanisms of Attentional Control.

    ERIC Educational Resources Information Center

    Wilke, Thomas

    Lack of attentional control--inability to concentrate--has often made the difference between successful and unsuccessful performance on the part of athletes. Attention is controlled neurologically by a very complex interaction of a large portion of the cerebrum and is not localized to any one structure. The mechanism involves a memory retrieval…

  12. Changes in Selection Policy in Hungary: The Case of the Admission System in Higher Education.

    ERIC Educational Resources Information Center

    Lukacs, Peter

    1989-01-01

    Presents a historical overview of selection mechanisms determining admission to higher education in Hungary. Discusses traditional centralized control of society and education, shifts in university admission criteria from family background and financial position to political reliability to knowledge and competence, and current trends. Contains 30…

  13. Relationships among Reading Performance, Locus of Control and Achievement for Marginal Admission Students.

    ERIC Educational Resources Information Center

    Pepper, Roger S.; Drexler, John A., Jr.

    The first phase of the study was a 2 x 2 factorial design, with locus of control and instructional method (lecture and demonstration) as independent variables and honor point average (HPA) as the dependent variable. The second phase used correlational techniques to test the extent to which reading performance and traditional predictors of…

  14. Universal Controller for Spacecraft Mechanisms

    NASA Technical Reports Server (NTRS)

    Levanas, Greg; McCarthy, Thomas; Hunter, Don; Buchanan, Christine; Johnson, Michael; Cozy, Raymond; Morgan, Albert; Tran, Hung

    2006-01-01

    An electronic control unit has been fabricated and tested that can be replicated as a universal interface between the electronic infrastructure of a spacecraft and a brushless-motor (or other electromechanical actuator) driven mechanism that performs a specific mechanical function within the overall spacecraft system. The unit includes interfaces to a variety of spacecraft sensors, power outputs, and has selectable actuator control parameters making the assembly a mechanism controller. Several control topologies are selectable and reconfigurable at any time. This allows the same actuator to perform different functions during the mission life of the spacecraft. The unit includes complementary metal oxide/semiconductor electronic components on a circuit board of a type called rigid flex (signifying flexible printed wiring along with a rigid substrate). The rigid flex board is folded to make the unit fit into a housing on the back of a motor. The assembly has redundant critical interfaces, allowing the controller to perform time-critical operations when no human interface with the hardware is possible. The controller is designed to function over a wide temperature range without the need for thermal control, including withstanding significant thermal cycling, making it usable in nearly all environments that spacecraft or landers will endure. A prototype has withstood 1,500 thermal cycles between 120 and +85 C without significant deterioration of its packaging or electronic function. Because there is no need for thermal control and the unit is addressed through a serial bus interface, the cabling and other system hardware are substantially reduced in quantity and complexity, with corresponding reductions in overall spacecraft mass and cost.

  15. The Effect of Health-Facility Admission and Skilled Birth Attendant Coverage on Maternal Survival in India: A Case-Control Analysis

    PubMed Central

    Montgomery, Ann L.; Fadel, Shaza; Kumar, Rajesh; Bondy, Sue; Moineddin, Rahim; Jha, Prabhat

    2014-01-01

    Background Research in areas of low skilled attendant coverage found that maternal mortality is paradoxically higher in women who seek obstetric care. We estimated the effect of health-facility admission on maternal survival, and how this effect varies with skilled attendant coverage across India. Methods/Findings Using unmatched population-based case-control analysis of national datasets, we compared the effect of health-facility admission at any time (antenatal, intrapartum, postpartum) on maternal deaths (cases) to women reporting pregnancies (controls). Probability of maternal death decreased with increasing skilled attendant coverage, among both women who were and were not admitted to a health-facility, however, the risk of death among women who were admitted was higher (at 50% coverage, OR = 2.32, 95% confidence interval 1.85–2.92) than among those women who were not; while at higher levels of coverage, the effect of health-facility admission was attenuated. In a secondary analysis, the probability of maternal death decreased with increasing coverage among both women admitted for delivery or delivered at home but there was no effect of admission for delivery on mortality risk (50% coverage, OR = 1.0, 0.80–1.25), suggesting that poor quality of obstetric care may have attenuated the benefits of facility-based care. Subpopulation analysis of obstetric hemorrhage cases and report of ‘excessive bleeding’ in controls showed that the probability of maternal death decreased with increasing skilled attendant coverage; but the effect of health-facility admission was attenuated (at 50% coverage, OR = 1.47, 0.95–1.79), suggesting that some of the effect in the main model can be explained by women arriving at facility with complications underway. Finally, highest risk associated with health-facility admission was clustered in women with education 8 years. Conclusions The effect of health-facility admission did vary by skilled attendant coverage, and

  16. Mechanical control of electroresistive switching

    SciTech Connect

    Kim, Yunseok; Kelly, Simon J; Strelcov, Evgheni; Jesse, Stephen; Biegalski, Michael D; Balke, Nina; Maksymovych, Petro; Kalinin, Sergei V

    2013-01-01

    Hysteretic metal-insulator transitions (MIT) mediated by ionic dynamics or ferroic phase transitions underpin emergent applications for non-volatile memories and logic devices. The vast majority of applications and studies have explored the MIT coupled to the electric field or temperarture. Here, we argue that MIT coupled to ionic dynamics should allow control by mechanical stimuli, the behavior we refer to as piezochemical effect. We verify this effect experimentally, and demonstrate that it allows both studying materials physics and enabling novel data storage technologies with mechanical writing and current based read-out.

  17. Control mechanism for a windmill

    SciTech Connect

    Browning, J.A.

    1983-02-08

    A method and apparatus are provided for controlling the maximum power of a hydraulic windmill which is achieved by utilizing the overpressure created in a closed loop hydraulic energy conversion system to rotate the tail of the windmill away from its operating plane to reduce the power transmitted from the wind to the blades of the windmill. A mechanical braking mechanism may be applied to the windmill blade driven rotatable shaft upon a sensed overpressure in the hydraulic fluid which acts through a differential between the hydraulic overpressure and a preset pressure to effect closure of the brake.

  18. Effectiveness of telemonitoring integrated into existing clinical services on hospital admission for exacerbation of chronic obstructive pulmonary disease: researcher blind, multicentre, randomised controlled trial

    PubMed Central

    Hanley, Janet; McCloughan, Lucy; Todd, Allison; Krishan, Ashma; Lewis, Stephanie; Stoddart, Andrew; van der Pol, Marjon; MacNee, William; Sheikh, Aziz; Pagliari, Claudia; McKinstry, Brian

    2013-01-01

    Objective To test the effectiveness of telemonitoring integrated into existing clinical services such that intervention and control groups have access to the same clinical care. Design Researcher blind, multicentre, randomised controlled trial. Setting UK primary care (Lothian, Scotland). Participants Adults with at least one admission for chronic obstructive pulmonary disease (COPD) in the year before randomisation. We excluded people who had other significant lung disease, who were unable to provide informed consent or complete the study, or who had other significant social or clinical problems. Interventions Participants were recruited between 21 May 2009 and 28 March 2011, and centrally randomised to receive telemonitoring or conventional self monitoring. Using a touch screen, telemonitoring participants recorded a daily questionnaire about symptoms and treatment use, and monitored oxygen saturation using linked instruments. Algorithms, based on the symptom score, generated alerts if readings were omitted or breached thresholds. Both groups received similar care from existing clinical services. Main outcome measures The primary outcome was time to hospital admission due to COPD exacerbation up to one year after randomisation. Other outcomes included number and duration of admissions, and validated questionnaire assessments of health related quality of life (using St George’s respiratory questionnaire (SGRQ)), anxiety or depression (or both), self efficacy, knowledge, and adherence to treatment. Analysis was intention to treat. Results Of 256 patients completing the study, 128 patients were randomised to telemonitoring and 128 to usual care; baseline characteristics of each group were similar. The number of days to admission did not differ significantly between groups (adjusted hazard ratio 0.98, 95% confidence interval 0.66 to 1.44). Over one year, the mean number of COPD admissions was similar in both groups (telemonitoring 1.2 admissions per person

  19. Expenditure optimization in a problem of controlled motion of mechanical systems

    NASA Astrophysics Data System (ADS)

    Babadzanjanz, Levon K.; Pototskaya, Irina Yu.; Pupysheva, Yulia Yu.

    2016-06-01

    The controlled motion which is represented by the linear ODE system with constant coefficients is considered. The admissible control is a piecewise constant function that blanks selected frequency components of the solution of linear equations at the moment T. As "the expenditure" functional we use the integral of the sum of the modules of coordinates of the control along the interval [0, T]. The problem under consideration is to construct an admissible control which minimizes the Expenditure. To solve this problem the method is proposed which leads to explicit formulas. All results of research are formulated as the theorem. These results can be applied not only in mechanical controlled systems, but also in any problem that can be described by the system of ordinary differential equations with control.

  20. Autoregulatory mechanisms controlling the microprocessor.

    PubMed

    Triboulet, Robinson; Gregory, Richard I

    2011-01-01

    The Microprocessor, comprising the ribonuclease Drosha and its essential cofactor, the double-stranded RNA-binding protein, DGCR8, is essential for the first step of the miRNA biogenesis pathway. It specifically cleaves double-stranded RNA within stem-loop structures of primary miRNA transcripts (pri-miRNAs) to generate precursor (pre-miRNA) intermediates. Pre-miRNAs are subsequently processed by Dicer to their mature ∼22 nt form. Thus, Microprocessor is essential for miRNA maturation, and pri-miRNA cleavage by this complex defines one end of the mature miRNA. Moreover, it is emerging that dysregulation of the Microprocessor is associated with various human diseases. It is therefore important to understand the mechanisms by which the expression of the subunits of the Microprocessor is regulated. Recent findings have uncovered a post-transcriptional mechanism that maintains the integrity of the Microprocessor. These studies revealed that the Microprocessor is involved in the processing of the messenger RNA (mRNA) that encodes DGCR8. This regulatory feedback loop, along with the reported role played by DGCR8 in the stabilization of Drosha protein, is part of a newly identified regulatory mechanism controlling Microprocessor activity.

  1. Autoregulatory mechanisms controlling the Microprocessor.

    PubMed

    Triboulet, Robinson; Gregory, Richard I

    2010-01-01

    The Microprocessor, comprising the ribonuclease Drosha and its essential cofactor, the double-stranded RNA-binding protein, DGCR8, is essential for the first step of the miRNA biogenesis pathway. It specifically cleaves double-stranded RNA within stem-loop structures of primary miRNA transcripts (pri-miRNAs) to generate precursor (pre-miRNA) intermediates. Pre-miRNAs are subsequently processed by Dicer to their mature 22 nt form. Thus, Microprocessor is essential for miRNA maturation, and pri-miRNA cleavage by this complex defines one end of the mature miRNA. Moreover, it is emerging that dysregulation of the Microprocessor is associated with various human diseases. It is therefore important to understand the mechanisms by which the expression of the subunits of the Microprocessor is regulated. Recent findings have uncovered a post-transcriptional mechanism that maintains the integrity of the Microprocessor. These studies revealed that the Microprocessor is involved in the processing of the messenger RNA (mRNA) that encodes DGCR8. This regulatory feedback loop, along with the reported role played by DGCR8 in the stabilization of Drosha protein, is part ofa newly identified regulatory mechanism controlling Microprocessor activity.

  2. School Admissions Reform in Chicago and England: Comparing Mechanisms by Their Vulnerability to Manipulation. NBER Working Paper No. 16783

    ERIC Educational Resources Information Center

    Pathak, Parag A.; Sonmez, Tayfun

    2011-01-01

    In Fall 2009, officials from Chicago Public Schools changed their assignment mechanism for coveted spots at selective college preparatory high schools midstream. After asking about 14,000 applicants to submit their preferences for schools under one mechanism, the district asked them re-submit their preferences under a new mechanism. Officials were…

  3. Tuneable Auxiliary Control Mechanisms For RUM Actuators

    NASA Technical Reports Server (NTRS)

    Polites, Michael E.; Alhorn, Dean C.

    1995-01-01

    Tuneable auxiliary control mechanisms for rotating unbalanced-mass (RUM) actuators used to maximize scan amplitudes and/or minimize power consumption during changing conditions. This type of mechanism more sophisticated version of type of mechanism described in "Auxiliary Control Mechanisms for RUM Actuators" (MFS-28817). Torsional stiffness of torsionally flexible coupling made adjustable on command. Torsionally flexible coupling in tuneable version of auxiliary control mechanism adjustable by use of stepping-motor-driven worm-gear mechanism that varies bending length of flexible blade.

  4. Cooling Mechanical Oscillators by Coherent Control

    NASA Astrophysics Data System (ADS)

    Frimmer, Martin; Gieseler, Jan; Novotny, Lukas

    2016-10-01

    In optomechanics, electromagnetic fields are harnessed to control a single mode of a mechanically compliant system, while other mechanical degrees of freedom remain unaffected due to the modes' mutual orthogonality and high quality factor. Extension of the optical control beyond the directly addressed mode would require a controlled coupling between mechanical modes. Here, we introduce an optically controlled coupling between two oscillation modes of an optically levitated nanoparticle. We sympathetically cool one oscillation mode by coupling it coherently to the second mode, which is feedback cooled. Furthermore, we demonstrate coherent energy transfer between mechanical modes and discuss its application for ground-state cooling.

  5. Mechanical control of cardiac myofibroblasts.

    PubMed

    van Putten, Sander; Shafieyan, Yousef; Hinz, Boris

    2016-04-01

    Fibroblasts produce and turn over collagenous extracellular matrix as part of the normal adaptive response to increased mechanical load in the heart, e.g. during prolonged exercise. However, chronic overload as a consequence of hypertension or myocardial injury trigger a repair program that culminates in the formation of myofibroblasts. Myofibroblasts are opportunistically activated from various precursor cells that all acquire a phenotype promoting excessive collagen secretion and contraction of the neo-matrix into stiff scar tissue. Stiff fibrotic tissue reduces heart distensibility, impedes pumping and valve function, contributes to diastolic and systolic dysfunction, and affects myocardial electrical transmission, potentially leading to arrhythmia and heart failure. Here, we discuss how mechanical factors, such as matrix stiffness and strain, are feeding back and cooperate with cytokine signals to drive myofibroblast activation. We elaborate on the importance of considering the mechanical boundary conditions in the heart to generate better cell culture models for mechanistic studies of cardiac fibroblast function. Elements of the force transmission and mechanoperception apparatus acting in myofibroblasts are presented as potential therapeutic targets to treat fibrosis. PMID:26620422

  6. What Admissions Officials Think

    ERIC Educational Resources Information Center

    Hoover, Eric

    2008-01-01

    Over the past two decades, college admissions has become a prime-time preoccupation. Most people know at least something about the process, especially if they have a teenager in high school and a college guide on their coffee table. Nonetheless, widespread public misconceptions persist about admissions requirements, the selection process, and the…

  7. A Stunning Admission

    ERIC Educational Resources Information Center

    Hu, Helen

    2012-01-01

    Few people set out to become admissions counselors, say people in the profession. But the field is requiring skills that are more demanding and varied than ever. And at a time when universities are looking especially hard at the bottom line, people in admissions need to constantly learn new things and make themselves indispensable. Counselors…

  8. Technology in International Admissions

    ERIC Educational Resources Information Center

    White, Elizabeth

    2012-01-01

    In a relatively short time, technology applications have become an essential feature of the admissions business. They make the jobs of international admissions professionals easier in many ways, allowing for more robust communication with applicants and counselors, a streamlined application process, and quicker access to information about…

  9. Cardiovascular physiology: mechanisms of control

    NASA Astrophysics Data System (ADS)

    Abbott, Jonathan A.

    2001-10-01

    In order to maintain homeostasis, the heart must pump blood commensurate with the metabolic needs of the body and do so at a pressure that is adequate to perfuse the vital organs. Basic cardiovascular physiology is reviewed and emphasis is place on those factors that are important in the control of cardiac output, heart rate and blood pressure.

  10. Controlled Thermo-Mechanical Processing

    SciTech Connect

    2005-09-01

    The CTMP technology has the potential for widespread application in all major sectors of the domestic tube and pipe industry; two of the largest sectors are seamless mechanical tubing and seamless oil country tubular goods. It has been proven for the spheroidized annealing heat cycle for through-hardened steels and has led to the development of a recipe for automotive gear steels. Potential applications also exist in the smaller sectors of seamless line pipe, pressure tubing, and stainless tubing. The technology could also apply to non-ferrous metal industries, such as titanium.

  11. Primary Path Reservation Using Enhanced Slot Assignment in TDMA for Session Admission

    PubMed Central

    Koneri Chandrasekaran, Suresh; Savarimuthu, Prakash; Andi Elumalai, Priya; Ayyaswamy, Kathirvel

    2015-01-01

    Mobile ad hoc networks (MANET) is a self-organized collection of nodes that communicates without any infrastructure. Providing quality of service (QoS) in such networks is a competitive task due to unreliable wireless link, mobility, lack of centralized coordination, and channel contention. The success of many real time applications is purely based on the QoS, which can be achieved by quality aware routing (QAR) and admission control (AC). Recently proposed QoS mechanisms do focus completely on either reservation or admission control but are not better enough. In MANET, high mobility causes frequent path break due to the fact that every time the source node must find the route. In such cases the QoS session is affected. To admit a QoS session, admission control protocols must ensure the bandwidth of the relaying path before transmission starts; reservation of such bandwidth noticeably improves the admission control performance. Many TDMA based reservation mechanisms are proposed but need some improvement over slot reservation procedures. In order to overcome this specific issue, we propose a framework—PRAC (primary path reservation admission control protocol), which achieves improved QoS by making use of backup route combined with resource reservation. A network topology has been simulated and our approach proves to be a mechanism that admits the session effectively. PMID:25874245

  12. Primary path reservation using enhanced slot assignment in TDMA for session admission.

    PubMed

    Koneri Chandrasekaran, Suresh; Savarimuthu, Prakash; Andi Elumalai, Priya; Ayyaswamy, Kathirvel

    2015-01-01

    Mobile ad hoc networks (MANET) is a self-organized collection of nodes that communicates without any infrastructure. Providing quality of service (QoS) in such networks is a competitive task due to unreliable wireless link, mobility, lack of centralized coordination, and channel contention. The success of many real time applications is purely based on the QoS, which can be achieved by quality aware routing (QAR) and admission control (AC). Recently proposed QoS mechanisms do focus completely on either reservation or admission control but are not better enough. In MANET, high mobility causes frequent path break due to the fact that every time the source node must find the route. In such cases the QoS session is affected. To admit a QoS session, admission control protocols must ensure the bandwidth of the relaying path before transmission starts; reservation of such bandwidth noticeably improves the admission control performance. Many TDMA based reservation mechanisms are proposed but need some improvement over slot reservation procedures. In order to overcome this specific issue, we propose a framework-PRAC (primary path reservation admission control protocol), which achieves improved QoS by making use of backup route combined with resource reservation. A network topology has been simulated and our approach proves to be a mechanism that admits the session effectively. PMID:25874245

  13. Primary path reservation using enhanced slot assignment in TDMA for session admission.

    PubMed

    Koneri Chandrasekaran, Suresh; Savarimuthu, Prakash; Andi Elumalai, Priya; Ayyaswamy, Kathirvel

    2015-01-01

    Mobile ad hoc networks (MANET) is a self-organized collection of nodes that communicates without any infrastructure. Providing quality of service (QoS) in such networks is a competitive task due to unreliable wireless link, mobility, lack of centralized coordination, and channel contention. The success of many real time applications is purely based on the QoS, which can be achieved by quality aware routing (QAR) and admission control (AC). Recently proposed QoS mechanisms do focus completely on either reservation or admission control but are not better enough. In MANET, high mobility causes frequent path break due to the fact that every time the source node must find the route. In such cases the QoS session is affected. To admit a QoS session, admission control protocols must ensure the bandwidth of the relaying path before transmission starts; reservation of such bandwidth noticeably improves the admission control performance. Many TDMA based reservation mechanisms are proposed but need some improvement over slot reservation procedures. In order to overcome this specific issue, we propose a framework-PRAC (primary path reservation admission control protocol), which achieves improved QoS by making use of backup route combined with resource reservation. A network topology has been simulated and our approach proves to be a mechanism that admits the session effectively.

  14. Control mechanisms in physiological rhythms

    NASA Technical Reports Server (NTRS)

    Mizell, S.

    1973-01-01

    A search was made for the factors involved in regulating rhythmic body functions. The basic premise was that at a particular point in time, any cell can normally act in one of two ways. It can either be engaged in dividing or carrying out its particular function. Experimental results indicate rhythmic functions are controlled by a lighting regime and that an inverse correlation exists between rhythms of cell division and cell function. Data also show rhythms are a function of animal sex and environment.

  15. Axial-slot Air Admission for Controlling Performance of a One-quarter-annulus Turbojet Combustor and Comparison with Complete Engine

    NASA Technical Reports Server (NTRS)

    Mark, H; Mark, Herman; Zettle, Eugene V

    1952-01-01

    An investigation of a single-annulus turbojet combustor with slot-type air admission was conducted to demonstrate the application of certain design principles to the control of outlet-gas temperature distributions. Comparisons of performance of a one-quarter-annulus combustor (duct-type installation) and a full-annulus combustor (obtained in a full-scale turbojet engine) are presented to indicate the applicability of results obtained from combustion studies conducted in duct-type installations. A reasonable correlation existed between the performance of the one-quarter-annulus and full-annulus combustors except for temperature distribution. Sufficient trends did exist which made it possible to predict temperature distributions for the engine, although absolute correlation did not exist. A radial temperature distribution similar to that required for a given engine was obtained using a one-quarter-annulus duct-type setup to predict results.

  16. Enabling real-time H.26L video services over wireless ad hoc networks using joint admission and transmission power control

    NASA Astrophysics Data System (ADS)

    Pei, Yong; Modestino, James W.; Qu, Qi; Wang, Xiaochun

    2003-06-01

    In a wireless ad hoc network, packets are sent from node-to-node in a multihop fashion until they reach the destination. In this paper we investigate the capacity of a wireless ad hoc network in supporting packet video transport. The ad hoc network consists of n homogeneous video users with each of them also serving as a relay node for other users. We investigate how the time delay aspects the video throughput in such an ad hoc network and how to provide a time-delay bounded packet video delivery service over such a network? The analytical results indicate that appropriate joint admission and power control have to be employed in order to efficiently utilize the network capacity while operating under the delay constraint as the distance between source and destination changes.

  17. Pontine Mechanisms of Respiratory Control

    PubMed Central

    Dutschmann, Mathias; Dick, Thomas E.

    2015-01-01

    Pontine respiratory nuclei provide synaptic input to medullary rhythmogenic circuits to shape and adapt the breathing pattern. An understanding of this statement depends on appreciating breathing as a behavior, rather than a stereotypic rhythm. In this review, we focus on the pontine-mediated inspiratory off-switch (IOS) associated with postinspiratory glottal constriction. Further, IOS is examined in the context of pontine regulation of glottal resistance in response to multimodal sensory inputs and higher commands, which in turn rules timing, duration, and patterning of respiratory airflow. In addition, network plasticity in respiratory control emerges during the development of the pons. Synaptic plasticity is required for dynamic and efficient modulation of the expiratory breathing pattern to cope with rapid changes from eupneic to adaptive breathing linked to exploratory (foraging and sniffing) and expulsive (vocalizing, coughing, sneezing, and retching) behaviors, as well as conveyance of basic emotions. The speed and complexity of changes in the breathing pattern of behaving animals implies that “learning to breathe” is necessary to adjust to changing internal and external states to maintain homeostasis and survival. PMID:23720253

  18. Comparison of CATs, CURB-65 and PMEWS as Triage Tools in Pandemic Influenza Admissions to UK Hospitals: Case Control Analysis Using Retrospective Data

    PubMed Central

    Myles, Puja R.; Nguyen-Van-Tam, Jonathan S.; Lim, Wei Shen; Nicholson, Karl G.; Brett, Stephen J.; Enstone, Joanne E.; McMenamin, James; Openshaw, Peter J. M.; Read, Robert C.; Taylor, Bruce L.; Bannister, Barbara; Semple, Malcolm G.

    2012-01-01

    Triage tools have an important role in pandemics to identify those most likely to benefit from higher levels of care. We compared Community Assessment Tools (CATs), the CURB-65 score, and the Pandemic Medical Early Warning Score (PMEWS); to predict higher levels of care (high dependency - Level 2 or intensive care - Level 3) and/or death in patients at or shortly after admission to hospital with A/H1N1 2009 pandemic influenza. This was a case-control analysis using retrospectively collected data from the FLU-CIN cohort (1040 adults, 480 children) with PCR-confirmed A/H1N1 2009 influenza. Area under receiver operator curves (AUROC), sensitivity, specificity, positive predictive values and negative predictive values were calculated. CATs best predicted Level 2/3 admissions in both adults [AUROC (95% CI): CATs 0.77 (0.73, 0.80); CURB-65 0.68 (0.64, 0.72); PMEWS 0.68 (0.64, 0.73), p<0.001] and children [AUROC: CATs 0.74 (0.68, 0.80); CURB-65 0.52 (0.46, 0.59); PMEWS 0.69 (0.62, 0.75), p<0.001]. CURB-65 and CATs were similar in predicting death in adults with both performing better than PMEWS; and CATs best predicted death in children. CATs were the best predictor of Level 2/3 care and/or death for both adults and children. CATs are potentially useful triage tools for predicting need for higher levels of care and/or mortality in patients of all ages. PMID:22509303

  19. Mechanics and aerodynamics of insect flight control.

    PubMed

    Taylor, G K

    2001-11-01

    Insects have evolved sophisticated fight control mechanisms permitting a remarkable range of manoeuvres. Here, I present a qualitative analysis of insect flight control from the perspective of flight mechanics, drawing upon both the neurophysiology and biomechanics literatures. The current literature does not permit a formal, quantitative analysis of flight control, because the aerodynamic force systems that biologists have measured have rarely been complete and the position of the centre of gravity has only been recorded in a few studies. Treating the two best-known insect orders (Diptera and Orthoptera) separately from other insects, I discuss the control mechanisms of different insects in detail. Recent experimental studies suggest that the helicopter model of flight control proposed for Drosophila spp. may be better thought of as a facultative strategy for flight control, rather than the fixed (albeit selected) constraint that it is usually interpreted to be. On the other hand, the so-called 'constant-lift reaction' of locusts appears not to be a reflex for maintaining constant lift at varying angles of attack, as is usually assumed, but rather a mechanism to restore the insect to pitch equilibrium following a disturbance. Differences in the kinematic control mechanisms used by the various insect orders are related to differences in the arrangement of the wings, the construction of the flight motor and the unsteady mechanisms of lift production that are used. Since the evolution of insect flight control is likely to have paralleled the evolutionary refinement of these unsteady aerodynamic mechanisms, taxonomic differences in the kinematics of control could provide an assay of the relative importance of different unsteady mechanisms. Although the control kinematics vary widely between orders, the number of degrees of freedom that different insects can control will always be limited by the number of independent control inputs that they use. Control of the moments

  20. Age Related Decline in Postural Control Mechanisms.

    ERIC Educational Resources Information Center

    Stelmach, George E.; And Others

    1989-01-01

    Studied voluntary and reflexive mechanisms of postural control of young (N=8) and elderly (N=8) adults through measurement of reflexive reactions to large-fast and small-slow ankle rotation postural disturbances. Found reflexive mechanisms relatively intact for both groups although elderly appeared more disadvantaged when posture was under the…

  1. Noise control mechanisms of inside aircraft

    NASA Astrophysics Data System (ADS)

    Zverev, A. Ya.

    2016-07-01

    World trends in the development of methods and approaches to noise reduction in aircraft cabins are reviewed. The paper discusses the mechanisms of passive and active noise and vibration control, application of "smart" and innovative materials, new approaches to creating all fuselage-design elements, and other promising directions of noise control inside aircraft.

  2. Damper mechanism for nuclear reactor control elements

    DOEpatents

    Taft, William Elwood

    1976-01-01

    A damper mechanism which provides a nuclear reactor control element decelerating function at the end of the scram stroke. The total damping function is produced by the combination of two assemblies, which operate in sequence. First, a tapered dashram assembly decelerates the control element to a lower velocity, after which a spring hydraulic damper assembly takes over to complete the final damping.

  3. Identification and Control of Mechanical Systems

    NASA Astrophysics Data System (ADS)

    Juang, Jer-Nan; Phan, Minh Q.

    2001-08-01

    The control of vibrating systems is a significant issue in the design of aircraft, spacecraft, bridges, and high-rise buildings. This book discusses the control of vibrating systems, integrating structural dynamics, vibration analysis, modern control, and system identification. By integrating these subjects engineers will need only one book, rather than several texts or courses, to solve vibration control problems. The authors cover key developments in aerospace control and identification theory, including virtual passive control, observer and state-space identification, and data-based controller synthesis. They address many practical issues and applications, and show examples of how various methods are applied to real systems. Some methods show the close integration of system identification and control theory from the state-space perspective, rather than from the traditional input-output model perspective of adaptive control. This text will be useful for advanced undergraduate and beginning graduate students in aerospace, mechanical, and civil engineering, as well as for practicing engineers.

  4. Remote controlled vacuum joint closure mechanism

    DOEpatents

    Doll, David W.; Hager, E. Randolph

    1986-01-01

    A remotely operable and maintainable vacuum joint closure mechanism for a noncircular aperture is disclosed. The closure mechanism includes an extendible bellows coupled at one end to a noncircular duct and at its other end to a flange assembly having sealed grooves for establishing a high vacuum seal with the abutting surface of a facing flange which includes an aperture forming part of the system to be evacuated. A plurality of generally linear arrangements of pivotally coupled linkages and piston combinations are mounted around the outer surface of the duct and aligned along the length thereof. Each of the piston/linkage assemblies is adapted to engage the flange assembly by means of a respective piston and is further coupled to a remote controlled piston drive shaft to permit each of the linkages positioned on a respective flat outer surface of the duct to simultaneously and uniformly displace a corresponding piston and the flange assembly with which it is in contact along the length of the duct in extending the bellows to provide a high vacuum seal between the movable flange and the facing flange. A plurality of latch mechanisms are also pivotally mounted on the outside of the duct. A first end of each of the latch mechanisms is coupled to a remotely controlled latch control shaft for displacing the latch mechanism about its pivot point. In response to the pivoting displacement of the latch mechanism, a second end thereof is displaced so as to securely engage the facing flange.

  5. Lights, Camera, Counseling, Admission.

    ERIC Educational Resources Information Center

    McGowan, Andrew Scott

    1993-01-01

    Considers the use of video in college recruiting. Outlines the development and production of a television series that deals with the college admission and selection process. Notes that the series is broadcast on both education and public access cable stations. Describes series "American College Focus" as model to be used by school counselors and…

  6. The Admissions Equity Struggle

    ERIC Educational Resources Information Center

    Freedman, Eric

    2012-01-01

    It has been a long, litigious road from Heman Sweatt, an African-American mail carrier who wanted to attend the prestigious, all-White law school at the University of Texas at Austin in 1946, to Abigail Fisher, a White high school student who failed to win undergraduate admission to the same university a half-century later. Depending on what the…

  7. Stress controls the mechanics of collagen networks

    PubMed Central

    Licup, Albert James; Münster, Stefan; Sharma, Abhinav; Sheinman, Michael; Jawerth, Louise M.; Fabry, Ben; Weitz, David A.; MacKintosh, Fred C.

    2015-01-01

    Collagen is the main structural and load-bearing element of various connective tissues, where it forms the extracellular matrix that supports cells. It has long been known that collagenous tissues exhibit a highly nonlinear stress–strain relationship, although the origins of this nonlinearity remain unknown. Here, we show that the nonlinear stiffening of reconstituted type I collagen networks is controlled by the applied stress and that the network stiffness becomes surprisingly insensitive to network concentration. We demonstrate how a simple model for networks of elastic fibers can quantitatively account for the mechanics of reconstituted collagen networks. Our model points to the important role of normal stresses in determining the nonlinear shear elastic response, which can explain the approximate exponential relationship between stress and strain reported for collagenous tissues. This further suggests principles for the design of synthetic fiber networks with collagen-like properties, as well as a mechanism for the control of the mechanics of such networks. PMID:26195769

  8. Remote controlled vacuum joint closure mechanism

    DOEpatents

    Doll, D.W.; Hager, E.R.

    1984-02-22

    A remotely operable and maintainable vacuum joint closure mechanism for a noncircular aperture is disclosed. The closure mechanism includes an extendible bellows coupled at one end to a noncircular duct and at its other end to a flange assembly having sealed grooves for establishing a high vacuum seal with the abutting surface of a facing flange which includes an aperture forming part of the system to be evacuated. A plurality of generally linear arrangements of pivotally coupled linkages and piston combinations are mounted around the outer surface of the duct and aligned along the length thereof. Each of the piston/linkage assemblies is adapted to engage the flange assembly by means of a respective piston and is further coupled to a remote controlled piston drive shaft to permit each of the linkages positioned on a respective flat outer surface of the duct to simultaneously and uniformly displace a corresponding piston and the flange assembly with which it is in contact along the length of the duct in extending the bellows to provide a high vacuum seal between the movable flange and the facing flange. A plurality of latch mechanisms are also pivotally mounted on the outside of the duct. A first end of each of the latch mechanisms is coupled to a remotely controlled latch control shaft for displacing the latch mechanism about its pivot point. In response to the pivoting displacement of the latch mechanism, a second end thereof is displaced so as to securely engage the facing flange and maintain the high vacuum seal established by the displacement of the flange assembly and extension of the bellows without displacing the entire duct.

  9. Risk factors of direct heat-related hospital admissions during the 2009 heatwave in Adelaide, Australia: a matched case–control study

    PubMed Central

    Zhang, Ying; Nitschke, Monika; Krackowizer, Antoinette; Dear, Keith; Pisaniello, Dino; Weinstein, Philip; Tucker, Graeme; Shakib, Sepehr; Bi, Peng

    2016-01-01

    Objective The extreme heatwave of 2009 in South Australia dramatically increased morbidity, with a 14-fold increase in direct heat-related hospitalisation in metropolitan Adelaide. Our study aimed to identify risk factors for the excess morbidity. Design A matched case–control study of risk factors was conducted. Setting Patients and matched community controls were interviewed to gather data on demographics, living environment, social support, health status and behaviour changes during the heatwave. Participants Cases were all hospital admissions with heat-related diagnoses during the 5-day heatwave in 2009. Controls were randomly selected from communities. Outcome measures Descriptive analyses, simple and multiple conditional logistic regressions were performed. Adjusted ORs (AORs) were estimated. Results In total, 143 hospital patients and 143 matched community controls were interviewed, with a mean age of 73 years (SD 21), 96% European ethnicity, 63% retired, 36% with high school or higher education, and 8% institutional living. The regression model indicated that compared with the controls, cases were more likely to have heart disease (AOR=13.56, 95% CI 1.27 to 144.86) and dementia (AOR=26.43, 95% CI 1.99 to 350.73). The protective factors included higher education level (AOR=0.48, 95% CI 0.23 to 0.99), having air-conditioner in the bedroom (AOR=0.12, 95% CI 0.02 to 0.74), having an emergency button (AOR=0.09, 95% CI 0.01 to 0.96), using refreshment (AOR=0.10, 95% CI 0.01 to 0.84), and having more social activities (AOR=0.11, 95% CI 0.02 to 0.57). Conclusions Pre-existing heart disease and dementia significantly increase the risk of direct heat-related hospitalisations during heatwaves. The presence of an air-conditioner in the bedroom, more social activities, a higher education level, use of emergency buttons and refreshments reduce the risk during heatwaves. PMID:27256088

  10. Fully Mechanically Controlled Automated Electron Microscopic Tomography

    PubMed Central

    Liu, Jinxin; Li, Hongchang; Zhang, Lei; Rames, Matthew; Zhang, Meng; Yu, Yadong; Peng, Bo; Celis, César Díaz; Xu, April; Zou, Qin; Yang, Xu; Chen, Xuefeng; Ren, Gang

    2016-01-01

    Knowledge of three-dimensional (3D) structures of each individual particles of asymmetric and flexible proteins is essential in understanding those proteins’ functions; but their structures are difficult to determine. Electron tomography (ET) provides a tool for imaging a single and unique biological object from a series of tilted angles, but it is challenging to image a single protein for three-dimensional (3D) reconstruction due to the imperfect mechanical control capability of the specimen goniometer under both a medium to high magnification (approximately 50,000–160,000×) and an optimized beam coherence condition. Here, we report a fully mechanical control method for automating ET data acquisition without using beam tilt/shift processes. This method could reduce the accumulation of beam tilt/shift that used to compensate the error from the mechanical control, but downgraded the beam coherence. Our method was developed by minimizing the error of the target object center during the tilting process through a closed-loop proportional-integral (PI) control algorithm. The validations by both negative staining (NS) and cryo-electron microscopy (cryo-EM) suggest that this method has a comparable capability to other ET methods in tracking target proteins while maintaining optimized beam coherence conditions for imaging. PMID:27403922

  11. Fully Mechanically Controlled Automated Electron Microscopic Tomography

    NASA Astrophysics Data System (ADS)

    Liu, Jinxin; Li, Hongchang; Zhang, Lei; Rames, Matthew; Zhang, Meng; Yu, Yadong; Peng, Bo; Celis, César Díaz; Xu, April; Zou, Qin; Yang, Xu; Chen, Xuefeng; Ren, Gang

    2016-07-01

    Knowledge of three-dimensional (3D) structures of each individual particles of asymmetric and flexible proteins is essential in understanding those proteins’ functions; but their structures are difficult to determine. Electron tomography (ET) provides a tool for imaging a single and unique biological object from a series of tilted angles, but it is challenging to image a single protein for three-dimensional (3D) reconstruction due to the imperfect mechanical control capability of the specimen goniometer under both a medium to high magnification (approximately 50,000–160,000×) and an optimized beam coherence condition. Here, we report a fully mechanical control method for automating ET data acquisition without using beam tilt/shift processes. This method could reduce the accumulation of beam tilt/shift that used to compensate the error from the mechanical control, but downgraded the beam coherence. Our method was developed by minimizing the error of the target object center during the tilting process through a closed-loop proportional-integral (PI) control algorithm. The validations by both negative staining (NS) and cryo-electron microscopy (cryo-EM) suggest that this method has a comparable capability to other ET methods in tracking target proteins while maintaining optimized beam coherence conditions for imaging.

  12. Fully Mechanically Controlled Automated Electron Microscopic Tomography.

    PubMed

    Liu, Jinxin; Li, Hongchang; Zhang, Lei; Rames, Matthew; Zhang, Meng; Yu, Yadong; Peng, Bo; Celis, César Díaz; Xu, April; Zou, Qin; Yang, Xu; Chen, Xuefeng; Ren, Gang

    2016-01-01

    Knowledge of three-dimensional (3D) structures of each individual particles of asymmetric and flexible proteins is essential in understanding those proteins' functions; but their structures are difficult to determine. Electron tomography (ET) provides a tool for imaging a single and unique biological object from a series of tilted angles, but it is challenging to image a single protein for three-dimensional (3D) reconstruction due to the imperfect mechanical control capability of the specimen goniometer under both a medium to high magnification (approximately 50,000-160,000×) and an optimized beam coherence condition. Here, we report a fully mechanical control method for automating ET data acquisition without using beam tilt/shift processes. This method could reduce the accumulation of beam tilt/shift that used to compensate the error from the mechanical control, but downgraded the beam coherence. Our method was developed by minimizing the error of the target object center during the tilting process through a closed-loop proportional-integral (PI) control algorithm. The validations by both negative staining (NS) and cryo-electron microscopy (cryo-EM) suggest that this method has a comparable capability to other ET methods in tracking target proteins while maintaining optimized beam coherence conditions for imaging. PMID:27403922

  13. Control mechanisms of plastid gene expression

    SciTech Connect

    Gruissem, W.; Tonkyn, J.C.

    1993-12-31

    Plastid DNAs of higher plants contain approximately 150 genes that encode RNAs and proteins for genetic and photosynthetic functions of the organelle. Results published in the last few years illustrate that the spatial and temporal expression of these plastid genes is regulated, in part, at the transcriptional level, but that developmentally controlled changes in mRNA stability, translational activity, and protein phosphorylation also have an important role in the control of plastid functions. This comprehensive review summarizes and discusses the mechanisms by which regulation of gene expression is exerted at the transcriptional and post-transcriptional levels. It provides an overview of our current knowledge, but also emphasizes areas that are controversial and in which information on regulatory mechanisms is still incomplete. 455 refs., 3 figs., 3 tabs.

  14. Mechanical Control of Individual Superconducting Vortices

    PubMed Central

    2016-01-01

    Manipulating individual vortices in a deterministic way is challenging; ideally, manipulation should be effective, local, and tunable in strength and location. Here, we show that vortices respond to local mechanical stress applied in the vicinity of the vortex. We utilized this interaction to move individual vortices in thin superconducting films via local mechanical contact without magnetic field or current. We used a scanning superconducting quantum interference device to image vortices and to apply local vertical stress with the tip of our sensor. Vortices were attracted to the contact point, relocated, and were stable at their new location. We show that vortices move only after contact and that more effective manipulation is achieved with stronger force and longer contact time. Mechanical manipulation of vortices provides a local view of the interaction between strain and nanomagnetic objects as well as controllable, effective, and reproducible manipulation technique. PMID:26836018

  15. [Feedback control mechanisms of plant cell expansion

    SciTech Connect

    Cosgrove, D.J.

    1992-01-01

    We have generated considerable evidence for the significance of wall stress relaxation in the control of plant growth and found that several agents (gibberellin, light, genetic loci for dwarf stature) influence growth rate via alteration of wall relaxation. We have refined our methods for measuring wall relaxation and, moreover, have found that wall relaxation properties bear only a distance relationship to wall mechanical properties. We have garnered novel insights into the nature of cell expansion mechanisms by analyzing spontaneous fluctuations of plant growth rate in seedlings. These experiments involved the application of mathematical techniques for analyzing growth rate fluctuations and the development of new instrumentation for measuring and forcing plant growth in a controlled fashion. These studies conclude that growth rate fluctuations generated by the plant as consequence of a feedback control system. This conclusion has important implications for the nature of wall loosening processes and demands a different framework for thinking about growth control. It also implies the existence of a growth rate sensor.

  16. Fuel injection pump with spill control mechanism

    SciTech Connect

    Djordjevic, I.

    1987-02-24

    This patent describes a rotary fuel injection pump for an internal combustion engine, having a housing, a rotor rotatable in the housing, a charge pump having radially extending plunger bores in the rotor and a plunger pump for each plunger bore having a pumping plunger reciprocable in the bore. The pumping plungers have outward fuel intake strokes and inward fuel delivery strokes for supplying high pressure charges of fuel for fuel injection. A cam ring surrounds the rotor and is engageable with the plunger pumps to reciprocate the plungers as the rotor rotates. Bumping plunger timing means relatively angularly adjusts the cam ring and rotor adjusting the pumping plunger timing. A spill control mechanism has spill valve means connected to the charge pump for spill control of the high pressure charges of fuel. The improvement described here wherein the spill valve means comprises at least one rotary spill valve having a valve bore in the rotor connected to the charge pump and a rotary spill valve member rotatably mounted within the valve bore. The spill control mechanism comprises first means for rotating each rotary spill valve member in unison with the rotor and in synchronism with the reciprocable movement of the pumping plungers for spill control of the high pressure charges of fuel. The pumping plunger timing means and the first means provide for separate relative angular adjustment of the cam ring and rotor and relative angular adjustment of the rotary spill valve member of at least the one rotary spill valve and the rotor.

  17. New Interference Mechanism Controls Ultracold Chemistry

    NASA Astrophysics Data System (ADS)

    Kendrick, Brian K.; Hazra, Jisha; Balakrishnan, N.

    2016-05-01

    A newly discovered interference mechanism has been shown to control the outcome of ultracold chemical reactions. The mechanism originates from the unique properties associated with ultracold collisions, namely: (1) isotropic (s-wave) scattering and (2) an effective quantization of the scattering phase shift (which originates from the bound state structure of the molecule). These two properties can lead to maximum constructive or destructive interference between two interfering reaction pathways (such as exchange and non-exchange in systems with two or more identical nuclei). If the molecular system exhibits a conical intersection, then the associated geometric phase is shown to act as a ``quantum switch'' which can turn the reactivity on or off. Reaction rate coefficients for the O + OH --> H + O2 and H + H2, reactions are presented which explicitly demonstrate the effect. Experimentalists might exploit this new mechanism to control ultracold reactions by the application of external electric or magnetic fields or by the selection of a particular nuclear spin state. This work was supported in part by the LDRD program (Grant No. 20140309ER) at LANL (B.K.) and by NSF Grant PHY-1505557 (N.B.) and ARO MURI Grant No. W911NF-12-1-0476 (N.B.).

  18. Stirling engine control mechanism and method

    DOEpatents

    Dineen, John J.

    1983-01-01

    A reciprocating-to-rotating motion conversion and power control device for a Stirling engine includes a hub mounted on an offset portion of the output shaft for rotation relative to the shaft and for sliding motion therealong which causes the hub to tilt relative to the axis of rotation of the shaft. This changes the angle of inclination of the hub relative to the shaft axis and changes the axial stroke of a set of arms connected to the hub and nutating therewith. A hydraulic actuating mechanism is connected to the hub for moving its axial position along the shaft. A balancing wheel is linked to the hub and changes its angle of inclination as the angle of inclination of the hub changes to maintain the mechanism in perfect balance throughout its range of motion.

  19. Access control mechanisms for distributed healthcare environments.

    PubMed

    Sergl-Pommerening, Marita

    2004-01-01

    Today's IT-infrastructure provides more and more possibilities to share electronic patient data across several healthcare organizations and hospital departments. A strong requirement is sufficient data protection and security measures complying with the medical confidentiality and the data protection laws of each state or country like the European directive on data protection or the U.S. HIPAA privacy rule. In essence, the access control mechanisms and authorization structures of information systems must be able to realize the Need-To-Access principle. This principle can be understood as a set of context-sensitive access rules, regarding the patient's path across the organizations. The access control mechanisms of today's health information systems do not sufficiently satisfy this requirement, because information about participation of persons or organizations is not available within each system in a distributed environment. This problem could be solved by appropriate security services. The CORBA healthcare domain standard contains such a service for obtaining authorization decisions and administrating access decision policies (RAD). At the university hospital of Mainz we have developed an access control system (MACS), which includes the main functionality of the RAD specification and the access control logic that is needed for such a service. The basic design principles of our approach are role-based authorization, user rights with static and dynamic authorization data, context rules and the separation of three cooperating servers that provide up-to-date knowledge about users, roles and responsibilities. This paper introduces the design principles and the system design and critically evaluates the concepts based on practical experience.

  20. 40 CFR 85.1504 - Conditional admission.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Conditional admission. 85.1504 Section 85.1504 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and Motor Vehicle Engines §...

  1. 40 CFR 85.1504 - Conditional admission.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Conditional admission. 85.1504 Section 85.1504 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and Motor Vehicle Engines §...

  2. 40 CFR 85.1504 - Conditional admission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Conditional admission. 85.1504 Section 85.1504 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and Motor Vehicle Engines §...

  3. 40 CFR 85.1504 - Conditional admission.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Conditional admission. 85.1504 Section 85.1504 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and Motor Vehicle Engines §...

  4. 40 CFR 85.1504 - Conditional admission.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Conditional admission. 85.1504 Section 85.1504 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and Motor Vehicle Engines §...

  5. Dynamic congestion control mechanisms for MPLS networks

    NASA Astrophysics Data System (ADS)

    Holness, Felicia; Phillips, Chris I.

    2001-02-01

    Considerable interest has arisen in congestion control through traffic engineering from the knowledge that although sensible provisioning of the network infrastructure is needed, together with sufficient underlying capacity, these are not sufficient to deliver the Quality of Service required for new applications. This is due to dynamic variations in load. In operational Internet Protocol (IP) networks, it has been difficult to incorporate effective traffic engineering due to the limited capabilities of the IP technology. In principle, Multiprotocol Label Switching (MPLS), which is a connection-oriented label swapping technology, offers new possibilities in addressing the limitations by allowing the operator to use sophisticated traffic control mechanisms. This paper presents a novel scheme to dynamically manage traffic flows through the network by re-balancing streams during periods of congestion. It proposes management-based algorithms that will allow label switched routers within the network to utilize mechanisms within MPLS to indicate when flows are starting to experience frame/packet loss and then to react accordingly. Based upon knowledge of the customer's Service Level Agreement, together with instantaneous flow information, the label edge routers can then instigate changes to the LSP route and circumvent congestion that would hitherto violate the customer contacts.

  6. Electrochemical biofilm control: mechanism of action

    PubMed Central

    Istanbullu, Ozlem; Babauta, Jerome; Nguyen, Hung Duc; Beyenal, Haluk

    2014-01-01

    Although it has been previously demonstrated that an electrical current can be used to control biofilm growth on metal surfaces, the literature results are conflicting and there is no accepted mechanism of action. One of the suggested mechanisms is the production of hydrogen peroxide (H2O2) on metal surfaces. However, there are literature studies in which H2O2 could not be detected in the bulk solution. This is most likely because H2O2 was produced at a low concentration near the surface and could not be detected in the bulk solution. The goals of this research were (1) to develop a well-controlled system to explain the mechanism of action of the bioelectrochemical effect on 316L stainless steel (SS) surfaces and (2) to test whether the produced H2O2 can reduce cell growth on metal surfaces. It was found that H2O2 was produced near 316L SS surfaces when a negative potential was applied. The H2O2 concentration increased towards the surface, while the dissolved oxygen decreased when the SS surface was polarized to −600 mVAg/AgCl. When polarized and non-polarized surfaces with identical Pseudomonas aeruginosa PAO1 biofilms were continuously fed with air-saturated growth medium, the polarized surfaces showed minimal biofilm growth while there was significant biofilm growth on the non-polarized surfaces. Although there was no detectable H2O2 in the bulk solution, it was found that the surface concentration of H2O2 was able to prevent biofilm growth. PMID:22827804

  7. Changes of trabecular bone under control of biologically mechanical mechanism

    NASA Astrophysics Data System (ADS)

    Wang, C.; Zhang, C. Q.; Dong, X.; Wu, H.

    2008-10-01

    In this study, a biological process of bone remodeling was considered as a closed loop feedback control system, which enables bone to optimize and renew itself over a lifetime. A novel idea of combining strain-adaptive and damage-induced remodeling algorithms at Basic Multicellular Unit (BMU) level was introduced. In order to make the outcomes get closer to clinical observation, the stochastic occurrence of microdamage was involved and a hypothesis that remodeling activation probability is related to the value of damage rate was assumed. Integrated with Finite Element Analysis (FEA), the changes of trabecular bone in morphology and material properties were simulated in the course of five years. The results suggest that deterioration and anisotropy of trabecluar bone are inevitable with natural aging, and that compression rather than tension can be applied to strengthen the ability of resistance to fracture. This investigation helps to gain more insight the mechanism of bone loss and identify improved treatment and prevention for osteoporosis or stress fracture.

  8. Shift control mechanism for a manual transmission

    SciTech Connect

    Gugin, D.G.

    1991-08-06

    This patent describes a shift control mechanism for a manual transmission having a transmission gear housing and a manual shift selecting lever. It comprises a shift selecting shaft mounted within the transmission gear housing for rotation and axial translation in response to selective manipulation of the shift selecting lever; a shift sleeve supported from the transmission gear housing; an actuating member secured to the shift selecting shaft for rotation and axial translation with the shift selecting shaft; synchronizer assemblies; the actuating member individually operating the synchronizer assemblies in response to selected manipulation of the shift selecting lever; alignment guide means interactive between the shift selecting shaft and the transmission gear housing to permit axial translation of the shift selecting shaft only when the shift selecting shaft has been rotated to align a locator means with a locating means.

  9. Therapeutic Protein Aggregation: Mechanisms, Design, and Control

    PubMed Central

    Roberts, Christopher J.

    2014-01-01

    While it is well known that proteins are only marginally stable in their folded states, it is often less well appreciated that most proteins are inherently aggregation-prone in their unfolded or partially unfolded states, and the resulting aggregates can be extremely stable and long-lived. For therapeutic proteins, aggregates are a significant risk factor for deleterious immune responses in patients, and can form via a variety of mechanisms. Controlling aggregation using a mechanistic approach may allow improved design of therapeutic protein stability, as a complement to existing design strategies that target desired protein structures and function. Recent results highlight the importance of balancing protein environment with the inherent aggregation propensities of polypeptide chains. PMID:24908382

  10. Trends in Staphylococcus aureus bacteraemia and impacts of infection control practices including universal MRSA admission screening in a hospital in Scotland, 2006–2010: retrospective cohort study and time-series intervention analysis

    PubMed Central

    Edwards, Becky; López-Lozano, José-Maria; Gould, Ian

    2012-01-01

    Objectives To describe secular trends in Staphylococcus aureus bacteraemia (SAB) and to assess the impacts of infection control practices, including universal methicillin-resistant Staphylococcus aureus (MRSA) admission screening on associated clinical burdens. Design Retrospective cohort study and multivariate time-series analysis linking microbiology, patient management and health intelligence databases. Setting Teaching hospital in North East Scotland. Participants All patients admitted to Aberdeen Royal Infirmary between 1 January 2006 and 31 December 2010: n=420 452 admissions and 1 430 052 acute occupied bed days (AOBDs). Intervention Universal admission screening programme for MRSA (August 2008) incorporating isolation and decolonisation. Primary and secondary measures Hospital-wide prevalence density, hospital-associated incidence density and death within 30 days of MRSA or methicillin-sensitive Staphylococcus aureus (MSSA) bacteraemia. Results Between 2006 and 2010, prevalence density of all SAB declined by 41%, from 0.73 to 0.50 cases/1000 AOBDs (p=0.002 for trend), and 30-day mortality from 26% to 14% (p=0.013). Significant reductions were observed in MRSA bacteraemia only. Overnight admissions screened for MRSA rose from 43% during selective screening to >90% within 4 months of universal screening. In multivariate time-series analysis (R2 0.45 to 0.68), universal screening was associated with a 19% reduction in prevalence density of MRSA bacteraemia (−0.035, 95% CI −0.049 to −0.021/1000 AOBDs; p<0.001), a 29% fall in hospital-associated incidence density (−0.029, 95% CI −0.035 to −0.023/1000 AOBDs; p<0.001) and a 46% reduction in 30-day mortality (−15.6, 95% CI −24.1% to −7.1%; p<0.001). Positive associations with fluoroquinolone and cephalosporin use suggested that antibiotic stewardship reduced prevalence density of MRSA bacteraemia by 0.027 (95% CI 0.015 to 0.039)/1000 AOBDs. Rates of MSSA bacteraemia were not

  11. Spatial constancy mechanisms in motor control.

    PubMed

    Medendorp, W Pieter

    2011-02-27

    The success of the human species in interacting with the environment depends on the ability to maintain spatial stability despite the continuous changes in sensory and motor inputs owing to movements of eyes, head and body. In this paper, I will review recent advances in the understanding of how the brain deals with the dynamic flow of sensory and motor information in order to maintain spatial constancy of movement goals. The first part summarizes studies in the saccadic system, showing that spatial constancy is governed by a dynamic feed-forward process, by gaze-centred remapping of target representations in anticipation of and across eye movements. The subsequent sections relate to other oculomotor behaviour, such as eye-head gaze shifts, smooth pursuit and vergence eye movements, and their implications for feed-forward mechanisms for spatial constancy. Work that studied the geometric complexities in spatial constancy and saccadic guidance across head and body movements, distinguishing between self-generated and passively induced motion, indicates that both feed-forward and sensory feedback processing play a role in spatial updating of movement goals. The paper ends with a discussion of the behavioural mechanisms of spatial constancy for arm motor control and their physiological implications for the brain. Taken together, the emerging picture is that the brain computes an evolving representation of three-dimensional action space, whose internal metric is updated in a nonlinear way, by optimally integrating noisy and ambiguous afferent and efferent signals. PMID:21242137

  12. Spatial constancy mechanisms in motor control

    PubMed Central

    Medendorp, W. Pieter

    2011-01-01

    The success of the human species in interacting with the environment depends on the ability to maintain spatial stability despite the continuous changes in sensory and motor inputs owing to movements of eyes, head and body. In this paper, I will review recent advances in the understanding of how the brain deals with the dynamic flow of sensory and motor information in order to maintain spatial constancy of movement goals. The first part summarizes studies in the saccadic system, showing that spatial constancy is governed by a dynamic feed-forward process, by gaze-centred remapping of target representations in anticipation of and across eye movements. The subsequent sections relate to other oculomotor behaviour, such as eye–head gaze shifts, smooth pursuit and vergence eye movements, and their implications for feed-forward mechanisms for spatial constancy. Work that studied the geometric complexities in spatial constancy and saccadic guidance across head and body movements, distinguishing between self-generated and passively induced motion, indicates that both feed-forward and sensory feedback processing play a role in spatial updating of movement goals. The paper ends with a discussion of the behavioural mechanisms of spatial constancy for arm motor control and their physiological implications for the brain. Taken together, the emerging picture is that the brain computes an evolving representation of three-dimensional action space, whose internal metric is updated in a nonlinear way, by optimally integrating noisy and ambiguous afferent and efferent signals. PMID:21242137

  13. 32. 48' MILL STEAM ENGINE ADMISSION BOX (?), STEAM VALVE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. 48' MILL STEAM ENGINE ADMISSION BOX (?), STEAM VALVE, AND REVERSING MECHANISM LIFTING CYLINDER. - U.S. Steel Homestead Works, 48" Plate Mill, Along Monongahela River, Homestead, Allegheny County, PA

  14. Molecular mechanisms that control endothelial cell contacts.

    PubMed

    Vestweber, D

    2000-02-01

    Endothelial cell contacts control the permeability of the blood vessel wall. This allows the endothelium to form a barrier for solutes, macromolecules, and leukocytes between the vessel lumen and the interstitial space. Loss of this barrier function in pathophysiological situations can lead to extracellular oedema. The ability of leukocytes to enter tissue at sites of inflammation is dependent on molecular mechanisms that allow leukocytes to adhere to the endothelium and to migrate through the endothelial cell layer and the underlying basal lamina. It is a commonly accepted working hypothesis that inter-endothelial cell contacts are actively opened and closed during this process. Angiogenesis is another important process that requires well-controlled regulation of inter-endothelial cell contacts. The formation of new blood vessels by sprouting from pre-existing vessels depends on the loosening of established endothelial cell contacts and the migration of endothelial cells that form the outgrowing sprouts. This review focuses on the molecular composition of endothelial cell surface proteins and proteins of the cytoskeletal undercoat of the plasma membrane at sites of inter-endothelial cell contacts and discusses the current knowledge about the potential role of such molecules in the regulation of endothelial cell contacts. PMID:10685062

  15. Hospital admissions before and after shipyard closure.

    PubMed

    Iversen, L; Sabroe, S; Damsgaard, M T

    1989-10-28

    To determine the effect of job loss on health an investigation was made of admissions to hospitals in 887 men five years before and three years after the closure of a Danish shipyard. The control group comprised 441 men from another shipyard. The information on hospital admissions was obtained from the Danish national register of patients. The relative risk of admission in the control group dropped significantly in terms of the number of men admitted from the study group from 1.29 four to five years before closure to 0.74 in the three years after closure. This was especially true of admissions due to accidents (1.33 to 0.46) and diseases of the digestive system (4.53 to 1.03). For diseases of the circulatory system, particularly cardiovascular diseases, the relative risk increased from 0.8 to 1.60, and from 1.0 to 2.6 respectively. These changes in risk of illness after redundancy are probably a consequence of a change from the effects of a high risk work environment to the effects of psychosocial stresses such as job insecurity and unemployment.

  16. Hospital admissions before and after shipyard closure.

    PubMed

    Bartley, M; Fagin, L

    1990-03-01

    "To determine the effect of job loss on health an investigation was made of admissions to hospitals in 887 men five years before and three years after the closure of a Danish shipyard. The control group comprised 441 men from another shipyard. The information on hospital admissions was obtained from the Danish national register of patients. The relative risk of admission in the control group dropped significantly in terms of the number of men admitted from the study group from 1.29 four to five years before closure to 0.74 in the three years after closure. This was especially true of admissions due to accidents (1.33 to 0.46) and diseases of the digestive system (4.53 to 1.03). For diseases of the circulatory system, particularly cardiovascular diseases, the relative risk increased from 0.8 to 1.60, and from 1.0 to 2.6 respectively. These changes in risk of illness after redundancy are probably a consequence of a change from the effects of a high risk work environment to the effects of psychosocial stresses such as job insecurity and unemployment."

  17. The Changing College Admissions Scene.

    ERIC Educational Resources Information Center

    Sjogren, Cliff

    1983-01-01

    Discusses the status of college admissions and some of the forces that influenced college admissions policies during each of four three-year periods: the Sputnik Era (1957-60), the Postwar Baby Boom Era (1964-67), the "New Groups" Era (1971-74), and the Stable Enrollment Era (1978-81). (PGD)

  18. Control mechanisms for a nonlinear model of international relations

    SciTech Connect

    Pentek, A.; Kadtke, J.; Lenhart, S.; Protopopescu, V.

    1997-07-15

    Some issues of control in complex dynamical systems are considered. The authors discuss two control mechanisms, namely: a short range, reactive control based on the chaos control idea and a long-term strategic control based on an optimal control algorithm. They apply these control ideas to simple examples in a discrete nonlinear model of a multi-nation arms race.

  19. Cellular Mechanisms of Ciliary Length Control.

    PubMed

    Keeling, Jacob; Tsiokas, Leonidas; Maskey, Dipak

    2016-01-01

    Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility, and tissue homeostasis. Defects in ciliary structure or function are associated with multiple human disorders called ciliopathies. These diseases affect diverse tissues, including, but not limited to the eyes, kidneys, brain, and lungs. Many processes must be coordinated simultaneously in order to initiate ciliogenesis. These include cell cycle, vesicular trafficking, and axonemal extension. Centrioles play a central role in both cell cycle progression and ciliogenesis, making the transition between basal bodies and mitotic spindle organizers integral to both processes. The maturation of centrioles involves a functional shift from cell division toward cilium nucleation which takes place concurrently with its migration and fusion to the plasma membrane. Several proteinaceous structures of the distal appendages in mother centrioles are required for this docking process. Ciliary assembly and maintenance requires a precise balance between two indispensable processes; so called assembly and disassembly. The interplay between them determines the length of the resulting cilia. These processes require a highly conserved transport system to provide the necessary substances at the tips of the cilia and to recycle ciliary turnover products to the base using a based microtubule intraflagellar transport (IFT) system. In this review; we discuss the stages of ciliogenesis as well as mechanisms controlling the lengths of assembled cilia. PMID:26840332

  20. Cellular Mechanisms of Ciliary Length Control

    PubMed Central

    Keeling, Jacob; Tsiokas, Leonidas; Maskey, Dipak

    2016-01-01

    Cilia and flagella are evolutionarily conserved, membrane-bound, microtubule-based organelles on the surface of most eukaryotic cells. They play important roles in coordinating a variety of signaling pathways during growth, development, cell mobility, and tissue homeostasis. Defects in ciliary structure or function are associated with multiple human disorders called ciliopathies. These diseases affect diverse tissues, including, but not limited to the eyes, kidneys, brain, and lungs. Many processes must be coordinated simultaneously in order to initiate ciliogenesis. These include cell cycle, vesicular trafficking, and axonemal extension. Centrioles play a central role in both cell cycle progression and ciliogenesis, making the transition between basal bodies and mitotic spindle organizers integral to both processes. The maturation of centrioles involves a functional shift from cell division toward cilium nucleation which takes place concurrently with its migration and fusion to the plasma membrane. Several proteinaceous structures of the distal appendages in mother centrioles are required for this docking process. Ciliary assembly and maintenance requires a precise balance between two indispensable processes; so called assembly and disassembly. The interplay between them determines the length of the resulting cilia. These processes require a highly conserved transport system to provide the necessary substances at the tips of the cilia and to recycle ciliary turnover products to the base using a based microtubule intraflagellar transport (IFT) system. In this review; we discuss the stages of ciliogenesis as well as mechanisms controlling the lengths of assembled cilia. PMID:26840332

  1. Brain mechanisms that control sleep and waking

    NASA Astrophysics Data System (ADS)

    Siegel, Jerome

    This review paper presents a brief historical survey of the technological and early research that laid the groundwork for recent advances in sleep-waking research. A major advance in this field occurred shortly after the end of World War II with the discovery of the ascending reticular activating system (ARAS) as the neural source in the brain stem of the waking state. Subsequent research showed that the brain stem activating system produced cortical arousal via two pathways: a dorsal route through the thalamus and a ventral route through the hypothalamus and basal forebrain. The nuclei, pathways, and neurotransmitters that comprise the multiple components of these arousal systems are described. Sleep is now recognized as being composed of two very different states: rapid eye movements (REMs) sleep and non-REM sleep. The major findings on the neural mechanisms that control these two sleep states are presented. This review ends with a discussion of two current views on the function of sleep: to maintain the integrity of the immune system and to enhance memory consolidation.

  2. Spin-controlled mechanics in nanoelectromechanical systems

    NASA Astrophysics Data System (ADS)

    Radić, D.

    2015-03-01

    We consider a dc-electronic tunneling transport through a carbon nanotube suspended between normal-metal source and arbitrarily spin-polarized drain lead in the presence of an external magnetic field. We show that magnetomotive coupling between electrical current through the nanotube and its mechanical vibrations may lead to an electromechanical instability and give an onset of self-excited mechanical vibrations depending on spin polarization of the drain lead and frequency of vibrations. The self-excitation mechanism is based on correlation between the occupancy of quantized Zeeman-split electronic states in the nanotube and the direction of velocity of its mechanical motion. It is an effective gating effect by the presence of electron in the spin state which, through the Coulomb blockade, permits tunneling of electron to the drain predominantly only during a particular phase of mechanical vibration thus coherently changing mechanical momentum and leading into instability if mechanical damping is overcome.

  3. Controlling mechanisms of Thwaites Glacier, West Antarctica

    NASA Astrophysics Data System (ADS)

    Seroussi, H. L.; Morlighem, M.; Rignot, E. J.; Larour, E. Y.; Mouginot, J.; Khazendar, A.

    2013-12-01

    Ice shelves play a major role in the stability of fast flowing ice streams in Antarctica, by exerting buttressing on inland ice and controlling the discharge of ice into the ocean. However, the mechanisms at work remain poorly understood and interactions between floating and grounded ice need to be better characterized in order to estimate the impact of climate change on the ice sheets. Thwaites glacier, in West Antarctica, features a small and heavily fractured ice shelf that provides limited back stress pressure on inland ice but is pinned on the eastern part on a prominent ridge. Thwaites glacier has maintained a consistently high velocity and negative mass balance for at least 20 years. Recent observations show a widening of its fast flowing area as well as a sustained acceleration since 2006 and a rapid retreat of its grounding line in the center of the glacier. The objective of this work is to characterize the dynamic response of Thwaites glacier to changes in its floating tongue on decadal to centennial time scales. To achieve this objective, we rely on high resolution ice flow modeling and grounding line dynamics using the Ice Sheet System Model (ISSM). We will focus on the complex interplay between the main floating tongue of Thwaites Glacier and its eastern, slow moving ice shelf, which is pinned down by an ice rumple. The speed of the eastern ice shelf is strongly affected by the coupling with the main floating ice tongue, which results in significant fluctuations in speed of the eastern ice shelf the formation of ice shelf cracks at the grounding line during acceleration phases. Our results show that ice rigidity at the junction between the eastern and western part of the shelf controls the dynamic regime of the ice shelf and suggest that Thwaites Glacier is likely to undergo substantial changes in the coming decades. This work was performed at the California Institute of Technology's Jet Propulsion Laboratory and the University of California Irvine

  4. Adaptive mechanically controlled lubrication mechanism found in articular joints.

    PubMed

    Greene, George W; Banquy, Xavier; Lee, Dong Woog; Lowrey, Daniel D; Yu, Jing; Israelachvili, Jacob N

    2011-03-29

    Articular cartilage is a highly efficacious water-based tribological system that is optimized to provide low friction and wear protection at both low and high loads (pressures) and sliding velocities that must last over a lifetime. Although many different lubrication mechanisms have been proposed, it is becoming increasingly apparent that the tribological performance of cartilage cannot be attributed to a single mechanism acting alone but on the synergistic action of multiple "modes" of lubrication that are adapted to provide optimum lubrication as the normal loads, shear stresses, and rates change. Hyaluronic acid (HA) is abundant in cartilage and synovial fluid and widely thought to play a principal role in joint lubrication although this role remains unclear. HA is also known to complex readily with the glycoprotein lubricin (LUB) to form a cross-linked network that has also been shown to be critical to the wear prevention mechanism of joints. Friction experiments on porcine cartilage using the surface forces apparatus, and enzymatic digestion, reveal an "adaptive" role for an HA-LUB complex whereby, under compression, nominally free HA diffusing out of the cartilage becomes mechanically, i.e., physically, trapped at the interface by the increasingly constricted collagen pore network. The mechanically trapped HA-LUB complex now acts as an effective (chemically bound) "boundary lubricant"--reducing the friction force slightly but, more importantly, eliminating wear damage to the rubbing/shearing surfaces. This paper focuses on the contribution of HA in cartilage lubrication; however, the system as a whole requires both HA and LUB to function optimally under all conditions.

  5. 32 CFR 242.5 - Admission procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HEALTH SCIENCES § 242.5 Admission procedures. (a) Application—(1) Civilians. Civilians seeking admission to the School of Medicine shall make direct application following instructions published in...

  6. Differential Freshman Admission by Sex

    ERIC Educational Resources Information Center

    Suddick, David E.; McBee, M. Louise

    1974-01-01

    The authors report on a study whose purpose was to determine if, after adjusting for initial differences in high school averages and SAT scores via separate regression equations, differential admissions criterion by sex is justifiable. No justification is found. (RP)

  7. Controlled Unusual Stiffness of Mechanical Metamaterials.

    PubMed

    Lee, Wooju; Kang, Da-Young; Song, Jihwan; Moon, Jun Hyuk; Kim, Dongchoul

    2016-02-03

    Mechanical metamaterials that are engineered with sub-unit structures present unusual mechanical properties depending on the loading direction. Although they show promise, their practical utility has so far been somewhat limited because, to the best of our knowledge, no study about the potential of mechanical metamaterials made from sophisticatedly tailored sub-unit structures has been made. Here, we present a mechanical metamaterial whose mechanical properties can be systematically designed without changing its chemical composition or weight. We study the mechanical properties of triply periodic bicontinuous structures whose detailed sub-unit structure can be precisely fabricated using various sub-micron fabrication methods. Simulation results show that the effective wave velocity of the structures along with different directions can be designed to introduce the anisotropy of stiffness by changing a volume fraction and aspect ratio. The ratio of Young's modulus to shear modulus can be increased by up to at least 100, which is a 3500% increase over that of isotropic material (2.8, acrylonitrile butadiene styrene). Furthermore, Poisson's ratio of the constituent material changes the ratio while Young's modulus does not influence it. This study presents the promising potential of mechanical metamaterials for versatile industrial and biomedical applications.

  8. Controlled Unusual Stiffness of Mechanical Metamaterials

    PubMed Central

    Lee, Wooju; Kang, Da-Young; Song, Jihwan; Moon, Jun Hyuk; Kim, Dongchoul

    2016-01-01

    Mechanical metamaterials that are engineered with sub-unit structures present unusual mechanical properties depending on the loading direction. Although they show promise, their practical utility has so far been somewhat limited because, to the best of our knowledge, no study about the potential of mechanical metamaterials made from sophisticatedly tailored sub-unit structures has been made. Here, we present a mechanical metamaterial whose mechanical properties can be systematically designed without changing its chemical composition or weight. We study the mechanical properties of triply periodic bicontinuous structures whose detailed sub-unit structure can be precisely fabricated using various sub-micron fabrication methods. Simulation results show that the effective wave velocity of the structures along with different directions can be designed to introduce the anisotropy of stiffness by changing a volume fraction and aspect ratio. The ratio of Young’s modulus to shear modulus can be increased by up to at least 100, which is a 3500% increase over that of isotropic material (2.8, acrylonitrile butadiene styrene). Furthermore, Poisson’s ratio of the constituent material changes the ratio while Young’s modulus does not influence it. This study presents the promising potential of mechanical metamaterials for versatile industrial and biomedical applications. PMID:26837466

  9. Controlled Unusual Stiffness of Mechanical Metamaterials

    NASA Astrophysics Data System (ADS)

    Lee, Wooju; Kang, Da-Young; Song, Jihwan; Moon, Jun Hyuk; Kim, Dongchoul

    2016-02-01

    Mechanical metamaterials that are engineered with sub-unit structures present unusual mechanical properties depending on the loading direction. Although they show promise, their practical utility has so far been somewhat limited because, to the best of our knowledge, no study about the potential of mechanical metamaterials made from sophisticatedly tailored sub-unit structures has been made. Here, we present a mechanical metamaterial whose mechanical properties can be systematically designed without changing its chemical composition or weight. We study the mechanical properties of triply periodic bicontinuous structures whose detailed sub-unit structure can be precisely fabricated using various sub-micron fabrication methods. Simulation results show that the effective wave velocity of the structures along with different directions can be designed to introduce the anisotropy of stiffness by changing a volume fraction and aspect ratio. The ratio of Young’s modulus to shear modulus can be increased by up to at least 100, which is a 3500% increase over that of isotropic material (2.8, acrylonitrile butadiene styrene). Furthermore, Poisson’s ratio of the constituent material changes the ratio while Young’s modulus does not influence it. This study presents the promising potential of mechanical metamaterials for versatile industrial and biomedical applications.

  10. Finite-time Control of One-link Mechanical System

    NASA Astrophysics Data System (ADS)

    Matoba, Shunsuke; Nakamura, Nami; Nakamura, Hisakazu; Akiba, Hideyuki

    This paper considers finite-time position control of an one-link mechanical system. The system is modeled by discontinuous differential equations. In this paper, we prove that the Nakamura's local homogeneous controller based on a control Lyapunov function is valid to the position control of the robot manipulators, and show the effectiveness of the controller by experiments.

  11. Mechanisms of control of gene expression

    SciTech Connect

    Cullen, B.; Gage, L.P.; Siddiqui, M.A.Q.; Skalka, A.M.; Weissbach, H.

    1987-01-01

    This book examines an array of topics on the regulation of gene expression, including an examination of DNA-protein interactions and the role of oncogene proteins in normal and abnormal cellular responses. The book focuses on the control of mRNA transcription in eykaryotes and delineates other areas including gene regulation in prokaryotes and control of stable RNA synthesis.

  12. Passive dynamic controllers for nonlinear mechanical systems

    NASA Technical Reports Server (NTRS)

    Juang, Jer-Nan; Wu, Shih-Chin; Phan, Minh; Longman, Richard W.

    1991-01-01

    A methodology for model-independant controller design for controlling large angular motion of multi-body dynamic systems is outlined. The controlled system may consist of rigid and flexible components that undergo large rigid body motion and small elastic deformations. Control forces/torques are applied to drive the system and at the same time suppress the vibration due to flexibility of the components. The proposed controller consists of passive second-order systems which may be designed with little knowledge of the system parameter, even if the controlled system is nonlinear. Under rather general assumptions, the passive design assures that the closed loop system has guaranteed stability properties. Unlike positive real controller design, stabilization can be accomplished without direct velocity feedback. In addition, the second-order passive design allows dynamic feedback controllers with considerable freedom to tune for desired system response, and to avoid actuator saturation. After developing the basic mathematical formulation of the design methodology, simulation results are presented to illustrate the proposed approach to a flexible six-degree-of-freedom manipulator.

  13. Computer aided control of a mechanical arm

    NASA Technical Reports Server (NTRS)

    Derocher, W. L., Jr.; Zermuehlen, r. O.

    1979-01-01

    A method for computer-aided remote control of a six-degree-of-freedom manipulator arm involved in the on-orbit servicing of a spacecraft is presented. The control configuration features a supervisory type of control in which each of the segments of a module exchange trajectory is controlled automatically under human supervision, with manual commands to proceed to the next step and in the event of a failure or undesirable outcome. The implementation of the supervisory system is discussed in terms of necessary onboard and ground- or Orbiter-based hardware and software, and a one-g demonstration system built to allow further investigation of system operation is described. Possible applications of the system include the construction of satellite solar power systems, environmental testing and the control of heliostat solar power stations.

  14. Critical length scale controls adhesive wear mechanisms.

    PubMed

    Aghababaei, Ramin; Warner, Derek H; Molinari, Jean-Francois

    2016-01-01

    The adhesive wear process remains one of the least understood areas of mechanics. While it has long been established that adhesive wear is a direct result of contacting surface asperities, an agreed upon understanding of how contacting asperities lead to wear debris particle has remained elusive. This has restricted adhesive wear prediction to empirical models with limited transferability. Here we show that discrepant observations and predictions of two distinct adhesive wear mechanisms can be reconciled into a unified framework. Using atomistic simulations with model interatomic potentials, we reveal a transition in the asperity wear mechanism when contact junctions fall below a critical length scale. A simple analytic model is formulated to predict the transition in both the simulation results and experiments. This new understanding may help expand use of computer modelling to explore adhesive wear processes and to advance physics-based wear laws without empirical coefficients. PMID:27264270

  15. Critical length scale controls adhesive wear mechanisms

    PubMed Central

    Aghababaei, Ramin; Warner, Derek H.; Molinari, Jean-Francois

    2016-01-01

    The adhesive wear process remains one of the least understood areas of mechanics. While it has long been established that adhesive wear is a direct result of contacting surface asperities, an agreed upon understanding of how contacting asperities lead to wear debris particle has remained elusive. This has restricted adhesive wear prediction to empirical models with limited transferability. Here we show that discrepant observations and predictions of two distinct adhesive wear mechanisms can be reconciled into a unified framework. Using atomistic simulations with model interatomic potentials, we reveal a transition in the asperity wear mechanism when contact junctions fall below a critical length scale. A simple analytic model is formulated to predict the transition in both the simulation results and experiments. This new understanding may help expand use of computer modelling to explore adhesive wear processes and to advance physics-based wear laws without empirical coefficients. PMID:27264270

  16. Critical length scale controls adhesive wear mechanisms

    NASA Astrophysics Data System (ADS)

    Aghababaei, Ramin; Warner, Derek H.; Molinari, Jean-Francois

    2016-06-01

    The adhesive wear process remains one of the least understood areas of mechanics. While it has long been established that adhesive wear is a direct result of contacting surface asperities, an agreed upon understanding of how contacting asperities lead to wear debris particle has remained elusive. This has restricted adhesive wear prediction to empirical models with limited transferability. Here we show that discrepant observations and predictions of two distinct adhesive wear mechanisms can be reconciled into a unified framework. Using atomistic simulations with model interatomic potentials, we reveal a transition in the asperity wear mechanism when contact junctions fall below a critical length scale. A simple analytic model is formulated to predict the transition in both the simulation results and experiments. This new understanding may help expand use of computer modelling to explore adhesive wear processes and to advance physics-based wear laws without empirical coefficients.

  17. [Classical dengue transmission dynamics involving mechanical control and prophylaxis].

    PubMed

    Toro-Zapata, Hernán D; Restrepo, Leonardo D; Vergaño-Salazar, Juan G; Muñoz-Loaiza, Aníbal

    2010-12-01

    Dengue fever transmission dynamics were studied in an endemic region considering the use of preventative measures and mechanical control in reducing transmission of the disease. A system of ordinary differential equations was proposed, describing the dynamics and their evolution as determined by numerical simulation. Different mechanical control and prophylaxis strategies were compared to the situation without control. The basic reproduction number R₀ was determined R₀ to show that if R₀ > 1 there would be a risk of an epidemic and otherwise the disease would have low impact levels. The basic reproduction number helps determine the dynamics' future pattern and contrast the results so obtained with those obtained numerically. It was concluded that although prophylaxis and mechanical control alone provide effective results in controlling the disease, if both controls are combined then infection levels become significantly reduced. Around 60 % mechanical control and prevention levels are needed to provide suitable results in controlling dengue outbreaks.

  18. 11. LAUNCH CONTROL SUPPORT BUILDING. INTERIOR OF MECHANICAL ROOM. VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. LAUNCH CONTROL SUPPORT BUILDING. INTERIOR OF MECHANICAL ROOM. VIEW TO SOUTHEAST. - Minuteman III ICBM Launch Control Facility November-1, 1.5 miles North of New Raymer & State Highway 14, New Raymer, Weld County, CO

  19. Mechanisms for leaf control of gas exchange

    SciTech Connect

    Mansfield, T.A.; Davies, W.J.

    1985-03-01

    Several mechanisms enable leaf stomata to optimize water loss with respect to carbon gain. Stomatal responses to environmental variation constitute a plant's first and second lines of defense against damaging water deficits. Changes in the concentrations of endogenous growth regulations and their influence on stomata may well be important to both defense strategies.

  20. Manipulator control and mechanization: A telerobot subsystem

    NASA Technical Reports Server (NTRS)

    Hayati, S.; Wilcox, B.

    1987-01-01

    The short- and long-term autonomous robot control activities in the Robotics and Teleoperators Research Group at the Jet Propulsion Laboratory (JPL) are described. This group is one of several involved in robotics and is an integral part of a new NASA robotics initiative called Telerobot program. A description of the architecture, hardware and software, and the research direction in manipulator control is given.

  1. 45 CFR 618.300 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 618.300 Admission. (a) General. No person shall, on the basis of sex, be denied admission, or be subjected to discrimination in admission, by...

  2. Cutaneous mechanisms of isometric ankle force control.

    PubMed

    Choi, Julia T; Lundbye-Jensen, Jesper; Leukel, Christian; Nielsen, Jens Bo

    2013-07-01

    The sense of force is critical in the control of movement and posture. Multiple factors influence our perception of exerted force, including inputs from cutaneous afferents, muscle afferents and central commands. Here, we studied the influence of cutaneous feedback on the control of ankle force output. We used repetitive electrical stimulation of the superficial peroneal (foot dorsum) and medial plantar nerves (foot sole) to disrupt cutaneous afferent input in 8 healthy subjects. We measured the effects of repetitive nerve stimulation on (1) tactile thresholds, (2) performance in an ankle force-matching and (3) an ankle position-matching task. Additional force-matching experiments were done to compare the effects of transient versus continuous stimulation in 6 subjects and to determine the effects of foot anesthesia using lidocaine in another 6 subjects. The results showed that stimulation decreased cutaneous sensory function as evidenced by increased touch threshold. Absolute dorsiflexion force error increased without visual feedback during peroneal nerve stimulation. This was not a general effect of stimulation because force error did not increase during plantar nerve stimulation. The effects of transient stimulation on force error were greater when compared to continuous stimulation and lidocaine injection. Position-matching performance was unaffected by peroneal nerve or plantar nerve stimulation. Our results show that cutaneous feedback plays a role in the control of force output at the ankle joint. Understanding how the nervous system normally uses cutaneous feedback in motor control will help us identify which functional aspects are impaired in aging and neurological diseases.

  3. Two Mechanisms to Avoid Control Conflicts Resulting from Uncoordinated Intent

    NASA Technical Reports Server (NTRS)

    Mishkin, Andrew H.; Dvorak, Daniel L.; Wagner, David A.; Bennett, Matthew B.

    2013-01-01

    This software implements a real-time access control protocol that is intended to make all connected users aware of the presence of other connected users, and which of them is currently in control of the system. Here, "in control" means that a single user is authorized and enabled to issue instructions to the system. The software The software also implements a goal scheduling mechanism that can detect situations where plans for the operation of a target system proposed by different users overlap and interact in conflicting ways. In such situations, the system can either simply report the conflict (rejecting one goal or the entire plan), or reschedule the goals in a way that does not conflict. The access control mechanism (and associated control protocol) is unique. Other access control mechanisms are generally intended to authenticate users, or exclude unauthorized access. This software does neither, and would likely depend on having some other mechanism to support those requirements.

  4. Parametric study of control mechanism of cortical bone remodeling under mechanical stimulus

    NASA Astrophysics Data System (ADS)

    Wang, Yanan; Qin, Qing-Hua

    2010-03-01

    The control mechanism of mechanical bone remodeling at cellular level was investigated by means of an extensive parametric study on a theoretical model described in this paper. From a perspective of control mechanism, it was found that there are several control mechanisms working simultaneously in bone remodeling which is a complex process. Typically, an extensive parametric study was carried out for investigating model parameter space related to cell differentiation and apoptosis which can describe the fundamental cell lineage behaviors. After analyzing all the combinations of 728 permutations in six model parameters, we have identified a small number of parameter combinations that can lead to physiologically realistic responses which are similar to theoretically idealized physiological responses. The results presented in the work enhanced our understanding on mechanical bone remodeling and the identified control mechanisms can help researchers to develop combined pharmacological-mechanical therapies to treat bone loss diseases such as osteoporosis.

  5. Control of Drop Motion by Mechanical Vibrations

    NASA Astrophysics Data System (ADS)

    Bestehorn, Michael

    2014-11-01

    Since the first experimental observations of Michael Faraday in 1831 it is known that a vibrating liquid may show an instability of its flat free surface with respect to oscillating regular surface patterns. We study thin liquid films on a horizontal substrate in the long wave approximation. The films are parametrically excited by mechanical horizontal or inclined oscillations. Inertia effects are taken into account and the standard thin film formulation is extended by a second equation for the vertically averaged mass flux. The films can be additionally unstable by Van der Waals forces on a partially wetting substrate, leading to the formation of drops. These drops can be manipulated by the vibrations to move in a desired direction. Linear results based on a damped complex valued Mathieu equation as well as fully nonlinear results using a reduced model will be presented, for more details see.

  6. Mechanisms and models of REM sleep control.

    PubMed

    McCarley, R W

    2004-07-01

    The first sections of this paper survey the history and recent developments relevant to the major neurotransmitters and neuromodulators involved in REM sleep control. The last portion of this paper proposes a structural model of cellular interaction that produces the REM sleep cycle, and constitutes a further revision of the reciprocal interaction model This paper proposes seven criteria to define a causal role in REM sleep control for putative neuro-transmitters/modulators. The principal criteria are measurements during behavioral state changes of the extracellular concentrations of the putative substances, and electrophysiological recording of their neuronal source. A cautionary note is that, while pharmacological manipulations are suggestive, they alone do not provide definitive causal evidence. The extensive body of in vivo and in vitro evidence supporting cholinergic promotion of REM sleep via LDT/PPT neuronal activity is surveyed. An interesting question raised by some studies is whether cholinergic influences in rat are less puissant than in cat. At least some of the apparent lesser REM-inducing effect of carbachol in the rat may be due to incomplete control of circadian influences; almost all experiments have been run only in the daytime, inactive period, when REM sleep is more prominent, rather than in the REM-sparse nighttime inactive period. Monoaminergic inhibition of cholinergic neurons, once thought to be the most shaky proposal of the reciprocal interaction model, now enjoys considerable support from both in vivo and in vitro data. However, the observed time course of monoaminergic neurons, their "turning off" discharge activity as REM sleep is approached and entered would seem to be difficult to produce from feedback inhibition, as originally postulated by the reciprocal interaction model. New data suggest the possibility that GABAergic inhibition of Locus Coeruleus and Dorsal Raphe monoaminergic neurons may account for the "REM-off" neurons turning

  7. Rapid Mechanically Controlled Rewiring of Neuronal Circuits

    PubMed Central

    Magdesian, Margaret H.; Lopez-Ayon, G. Monserratt; Mori, Megumi; Boudreau, Dominic; Goulet-Hanssens, Alexis; Sanz, Ricardo; Miyahara, Yoichi; Barrett, Christopher J.; Fournier, Alyson E.; De Koninck, Yves

    2016-01-01

    CNS injury may lead to permanent functional deficits because it is still not possible to regenerate axons over long distances and accurately reconnect them with an appropriate target. Using rat neurons, microtools, and nanotools, we show that new, functional neurites can be created and precisely positioned to directly (re)wire neuronal networks. We show that an adhesive contact made onto an axon or dendrite can be pulled to initiate a new neurite that can be mechanically guided to form new synapses at up to 0.8 mm distance in <1 h. Our findings challenge current understanding of the limits of neuronal growth and have direct implications for the development of new therapies and surgical techniques to achieve functional regeneration. SIGNIFICANCE STATEMENT Brain and spinal cord injury may lead to permanent disability and death because it is still not possible to regenerate neurons over long distances and accurately reconnect them with an appropriate target. Using microtools and nanotools we have developed a new method to rapidly initiate, elongate, and precisely connect new functional neuronal circuits over long distances. The extension rates achieved are ≥60 times faster than previously reported. Our findings have direct implications for the development of new therapies and surgical techniques to achieve functional regeneration after trauma and in neurodegenerative diseases. It also opens the door for the direct wiring of robust brain–machine interfaces as well as for investigations of fundamental aspects of neuronal signal processing and neuronal function. PMID:26791225

  8. Neural Control Mechanisms and Body Fluid Homeostasis

    NASA Technical Reports Server (NTRS)

    Johnson, Alan Kim

    1998-01-01

    The goal of the proposed research was to study the nature of afferent signals to the brain that reflect the status of body fluid balance and to investigate the central neural mechanisms that process this information for the activation of response systems which restore body fluid homeostasis. That is, in the face of loss of fluids from intracellular or extracellular fluid compartments, animals seek and ingest water and ionic solutions (particularly Na(+) solutions) to restore the intracellular and extracellular spaces. Over recent years, our laboratory has generated a substantial body of information indicating that: (1) a fall in systemic arterial pressure facilitates the ingestion of rehydrating solutions and (2) that the actions of brain amine systems (e.g., norepinephrine; serotonin) are critical for precise correction of fluid losses. Because both acute and chronic dehydration are associated with physiological stresses, such as exercise and sustained exposure to microgravity, the present research will aid in achieving a better understanding of how vital information is handled by the nervous system for maintenance of the body's fluid matrix which is critical for health and well-being.

  9. College Admissions: Beyond Conventional Testing

    ERIC Educational Resources Information Center

    Sternberg, Robert J.

    2012-01-01

    Standardized admissions tests such as the SAT (originally stood for "Scholastic Aptitude Test") and the ACT measure only a narrow segment of the skills needed to become an active citizen and possibly a leader who makes a positive, meaningful, and enduring difference to the world. The problem with these tests is that they promised, under what have…

  10. Admission to Selective Schools, Alphabetically

    ERIC Educational Resources Information Center

    Jurajda, Stepan; Munich, Daniel

    2010-01-01

    One's position in an alphabetically sorted list may be important in determining access to over-subscribed public services. Motivated by anecdotal evidence, we investigate the importance of the position in the alphabet of Czech students for their admission chances into over-subscribed schools. Empirical evidence based on the population of students…

  11. Admissions Plan Goes beyond Numbers

    ERIC Educational Resources Information Center

    Hoover, Eric

    2007-01-01

    Northeastern University's Torch Scholars Program is designed to seek out first-generation students who would not qualify under the university's regular admissions process. The scholarships go to motivated students who have shown determination in overcoming personal challenges. Northeastern believes the experiment will enhance the socioeconomic…

  12. Using Multimedia for Admission Recruitment.

    ERIC Educational Resources Information Center

    Gudema, Louis

    1995-01-01

    Multimedia can grab the attention of prospective students in an engaging, appealing way, while giving admission officers the opportunity to deliver information about every facet of campus life. Describes multimedia, its potential, and the production process as well as five current distribution methods. Discusses appropriateness of multimedia for…

  13. Admission Conditions and Graduates' Employability

    ERIC Educational Resources Information Center

    Alexandre, Fernando; Portela, Miguel; Sa, Carla

    2009-01-01

    In a context of increasing competition for students, admission conditions have been used as an instrument in a strategy of differentiation. Such a strategy is guided by short-run concerns, that is, the immediate need to attract more students. This article takes a longer term view, by examining graduates' employability. The authors find that…

  14. College Admission: Profession or Industry?

    ERIC Educational Resources Information Center

    Thacker, Lloyd

    1999-01-01

    Discusses how the condition and fate of both the college admissions profession and liberal arts education are linked, and how they are both threatened by elements of commercialism. Argues for reasserting professionalism by looking beyond the competitive advantage of the college's interest to serve a broader function as trustees of students'…

  15. Healthcare professionals' experiences with EHR-system access control mechanisms.

    PubMed

    Faxvaag, Arild; Johansen, Trond S; Heimly, Vigdis; Melby, Line; Grimsmo, Anders

    2011-01-01

    Access control mechanisms might influence on the information seeking and documentation behavior of clinicians. In this study, we have surveyed healthcare professionals in nursing homes and hospitals on their attitudes to, and experiences with using access control mechanisms. In some situations, the access control mechanisms of the EHR system made clinicians postpone documentation work. Their practice of reading what others have documented was also influenced. Not all clinicians logged out of the system when they left a workstation, and some clinicians reported to do some of their documentation work in the name of others. The reported practices might have implications for the safety of the patient.

  16. Robust vibration control of flexible linkage mechanisms using piezoelectric films

    NASA Astrophysics Data System (ADS)

    Liao, Wen-Hwei; Chou, Jyh-Horng; Horng, Ing-Rong

    1997-08-01

    Based on the state space model of the flexible linkage mechanism equipped with piezoelectric films, a robust control methodology for suppressing elastodynamic responses of the high-speed flexible linkage mechanism with linear time-varying parameter perturbations by employing an observer-based feedback controller is presented. The instability caused by the linear time-varying parameter perturbations and the instability caused by the combined effect of control and observation spillover are investigated and carefully prevented by two robust stability criteria proposed in this paper. Numerical simulation of a slider - crank mechanism example is performed to evaluate the improvement of the elastodynamic responses.

  17. Forecasting paediatric malaria admissions on the Kenya Coast using rainfall

    PubMed Central

    Karuri, Stella Wanjugu; Snow, Robert W.

    2016-01-01

    Background Malaria is a vector-borne disease which, despite recent scaled-up efforts to achieve control in Africa, continues to pose a major threat to child survival. The disease is caused by the protozoan parasite Plasmodium and requires mosquitoes and humans for transmission. Rainfall is a major factor in seasonal and secular patterns of malaria transmission along the East African coast. Objective The goal of the study was to develop a model to reliably forecast incidences of paediatric malaria admissions to Kilifi District Hospital (KDH). Design In this article, we apply several statistical models to look at the temporal association between monthly paediatric malaria hospital admissions, rainfall, and Indian Ocean sea surface temperatures. Trend and seasonally adjusted, marginal and multivariate, time-series models for hospital admissions were applied to a unique data set to examine the role of climate, seasonality, and long-term anomalies in predicting malaria hospital admission rates and whether these might become more or less predictable with increasing vector control. Results The proportion of paediatric admissions to KDH that have malaria as a cause of admission can be forecast by a model which depends on the proportion of malaria admissions in the previous 2 months. This model is improved by incorporating either the previous month's Indian Ocean Dipole information or the previous 2 months’ rainfall. Conclusions Surveillance data can help build time-series prediction models which can be used to anticipate seasonal variations in clinical burdens of malaria in stable transmission areas and aid the timing of malaria vector control. PMID:26842613

  18. Geomagnetic storms: association with incidence of depression as measured by hospital admission.

    PubMed

    Kay, R W

    1994-03-01

    The hypothesis that geomagnetic storms may partly account for the seasonal variation in the incidence of depression, by acting as a precipitant of depressive illness in susceptible individuals, is supported by a statistically significant 36.2% increase in male hospital admissions with a diagnosis of depressed phase, manic-depressive illness in the second week following such storms compared with geomagnetically quiet control periods. There is a smaller but not statistically significant increase in female psychotic depression and non-psychotic depression admissions following storms. There was no correlation between geomagnetic storm levels and number of male admissions with psychotic depression, which is consistent with a threshold event affecting predisposed individuals. Phase advance in pineal circadian rhythms of melatonin synthesis may be a possible mechanism of causation or be present as a consequence of 5-hydroxytryptamine and adrenergic system dysfunction associated with geomagnetic disturbance. Effects on cell membrane permeability, calcium channel activity and retinal magneto-receptors are suggested as possible underlying biochemical mechanisms. PMID:8199794

  19. Control of chaos: methods and applications in mechanics.

    PubMed

    Fradkov, Alexander L; Evans, Robin J; Andrievsky, Boris R

    2006-09-15

    A survey of the field related to control of chaotic systems is presented. Several major branches of research that are discussed are feed-forward ('non-feedback') control (based on periodic excitation of the system), the 'Ott-Grebogi-Yorke method' (based on the linearization of the Poincaré map), the 'Pyragas method' (based on a time-delayed feedback), traditional for control-engineering methods including linear, nonlinear and adaptive control. Other areas of research such as control of distributed (spatio-temporal and delayed) systems, chaotic mixing are outlined. Applications to control of chaotic mechanical systems are discussed.

  20. 28 CFR 549.42 - Involuntary admission.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ....42 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MEDICAL SERVICES Administrative Safeguards for Psychiatric Treatment and Medication § 549.42 Involuntary admission... voluntarily consent either to psychiatric admission or to medication, is subject to judicial...

  1. 28 CFR 549.42 - Involuntary admission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....42 Judicial Administration BUREAU OF PRISONS, DEPARTMENT OF JUSTICE INSTITUTIONAL MANAGEMENT MEDICAL SERVICES Administrative Safeguards for Psychiatric Treatment and Medication § 549.42 Involuntary admission... voluntarily consent either to psychiatric admission or to medication, is subject to judicial...

  2. 10 CFR 2.708 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... admission of the genuineness and authenticity of any relevant document described in or attached to the... document for which an admission of genuineness and authenticity is requested must be delivered with...

  3. An Analytical Dynamics Approach to the Control of Mechanical Systems

    NASA Astrophysics Data System (ADS)

    Mylapilli, Harshavardhan

    A new and novel approach to the control of nonlinear mechanical systems is presented in this study. The approach is inspired by recent results in analytical dynamics that deal with the theory of constrained motion. The control requirements on the dynamical system are viewed from an analytical dynamics perspective and the theory of constrained motion is used to recast these control requirements as constraints on the dynamical system. Explicit closed form expressions for the generalized nonlinear control forces are obtained by using the fundamental equation of mechanics. The control so obtained is optimal at each instant of time and causes the constraints to be exactly satisfied. No linearizations and/or approximations of the nonlinear dynamical system are made, and no a priori structure is imposed on the nature of nonlinear controller. Three examples dealing with highly nonlinear complex dynamical systems that are chosen from diverse areas of discrete and continuum mechanics are presented to demonstrate the control approach. The first example deals with the energy control of underactuated inhomogeneous nonlinear lattices (or chains), the second example deals with the synchronization of the motion of multiple coupled slave gyros with that of a master gyro, and the final example deals with the control of incompressible hyperelastic rubber-like thin cantilever beams. Numerical simulations accompanying these examples show the ease, simplicity and the efficacy with which the control methodology can be applied and the accuracy with which the desired control objectives can be met.

  4. 42 CFR 456.125 - Time limits for admission review.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...; or (b) Within one working day after the hospital is notified of the application for Medicaid, for an... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control: Hospitals Ur Plan....127, the UR plan must provide that review of each recipient's admission to the hospital is...

  5. Single-atom quantum control of macroscopic mechanical oscillators

    NASA Astrophysics Data System (ADS)

    Bariani, F.; Otterbach, J.; Tan, Huatang; Meystre, P.

    2014-01-01

    We investigate a hybrid electromechanical system consisting of a pair of charged macroscopic mechanical oscillators coupled to a small ensemble of Rydberg atoms. The resonant dipole-dipole coupling between an internal atomic Rydberg transition and the mechanics allows cooling to its motional ground state with a single atom despite the considerable mass imbalance between the two subsystems. We show that the rich electronic spectrum of Rydberg atoms, combined with their high degree of optical control, paves the way towards implementing various quantum-control protocols for the mechanical oscillators.

  6. Policies Governing Admission to Jordanian Public Universities

    ERIC Educational Resources Information Center

    Massadeh, Nassar

    2012-01-01

    This paper intends to discuss the policy of admission to Jordanian public universities. This admission rules are variable and open to almost 100% of the graduates from secondary schools. This might refer to the historical events and economic conditions that the country has gone through since its establishment. Furthermore, the admission policy is…

  7. 10 CFR 1042.300 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 1042.300 Admission. (a) General. No person shall, on the basis of sex, be denied admission,...

  8. 10 CFR 1042.300 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ENERGY (GENERAL PROVISIONS) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 1042.300 Admission. (a) General. No person shall, on the basis of sex, be denied admission,...

  9. 29 CFR 36.300 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 36.300 Admission. (a) General. No person shall, on the basis of sex, be denied admission, or...

  10. 29 CFR 36.300 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 36.300 Admission. (a) General. No person shall, on the basis of sex, be denied admission, or...

  11. 29 CFR 36.300 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 36.300 Admission. (a) General. No person shall, on the basis of sex, be denied admission, or...

  12. 18 CFR 1317.220 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... § 1317.220 Admissions. (a) Admissions to educational institutions prior to June 24, 1973, are not covered... shall be deemed to be an educational institution. (c) Application of §§ 1317.300 through .310. Except as... admission or recruitment in violation of §§ 1317.300 through 1317.310. (d) Educational institutions....

  13. Admission to Medical Education in Ten Countries.

    ERIC Educational Resources Information Center

    Burn, Barbara B., Ed.

    As part of a study of access and admission to higher education in Germany and the United States, a group of papers on medical admissions in various countries was commissioned. The papers presented in this book reveal wide differences in admissions policies and procedures. Barbara Burn examines some of the major issues in a foreword: representation…

  14. 7 CFR 501.2 - Admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Admission. 501.2 Section 501.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.2 Admission. Admission to...

  15. 7 CFR 501.2 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Admission. 501.2 Section 501.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.2 Admission. Admission to...

  16. 7 CFR 501.2 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Admission. 501.2 Section 501.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.2 Admission. Admission to...

  17. 7 CFR 501.2 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Admission. 501.2 Section 501.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.2 Admission. Admission to...

  18. 7 CFR 501.2 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Admission. 501.2 Section 501.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON U.S. MEAT ANIMAL RESEARCH CENTER, CLAY CENTER, NEBRASKA § 501.2 Admission. Admission to...

  19. The Ethics of Need-Blind Admission.

    ERIC Educational Resources Information Center

    Jump, James W.

    1995-01-01

    Discusses the need for consensus about the ethics of need-blind admission by focusing on principles concerning the practice of college admissions. Argues that colleges should not abandon need-blind admissions but should, instead, remove expectations that colleges should meet the full needs of all the students they accept. (RJM)

  20. 29 CFR 36.220 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Admissions. 36.220 Section 36.220 Labor Office of the Secretary of Labor NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 36.220 Admissions. (a) Admissions to educational institutions prior to June 24, 1973, are not covered by...

  1. The Evolution of College Admission Requirements

    ERIC Educational Resources Information Center

    Beale, Andrew V.

    2012-01-01

    The development of college admissions requirements during the seventeenth and eighteenth centuries was basically the story of the admission policies and practices at Harvard College. Candidates for admission were examined on their ability to read and translate Latin and Greek, and a careful check was made of their character and background. With…

  2. The Role of Noncognitive Assessment in Admissions

    ERIC Educational Resources Information Center

    Hoerle, Heather

    2014-01-01

    Confident that understanding and employing new approaches to assessment is a top priority for admissions professionals, the Secondary School Admission Test Board (SSATB) recently launched a Think Tank on the Future of Admission Assessment, with a two-year timeline and a charge to educate its membership and inspire greater innovation in admissions…

  3. Why Do Students Repeat Admissions Tests?

    ERIC Educational Resources Information Center

    Jones, Martha S.

    Attitudes and beliefs about the admissions process, especially the role of standardized testing in admissions, were examined for students who took a standardized admissions test more than once. Their attitudes were compared with those of students who did not repeat the test. About 200 preveterinary students who had taken the Veterinary Aptitude…

  4. Fairness and Undergraduate Admission: A Qualitative Exploration of Admissions Choices at the University of Oxford

    ERIC Educational Resources Information Center

    Zimdars, Anna

    2010-01-01

    The article investigates unequal admissions patterns at the University of Oxford. Statistical work shows differences in admission rates by social class, ethnicity, gender, qualification status and secondary schooling. In-depth interviews with admissions tutors, college and university officials and observations of eight admissions meetings provide…

  5. Applying Workspace Limitations in a Velocity-Controlled Robotic Mechanism

    NASA Technical Reports Server (NTRS)

    Abdallah, Muhammad E. (Inventor); Hargrave, Brian (Inventor); Platt, Robert J., Jr. (Inventor)

    2014-01-01

    A robotic system includes a robotic mechanism responsive to velocity control signals, and a permissible workspace defined by a convex-polygon boundary. A host machine determines a position of a reference point on the mechanism with respect to the boundary, and includes an algorithm for enforcing the boundary by automatically shaping the velocity control signals as a function of the position, thereby providing smooth and unperturbed operation of the mechanism along the edges and corners of the boundary. The algorithm is suited for application with higher speeds and/or external forces. A host machine includes an algorithm for enforcing the boundary by shaping the velocity control signals as a function of the reference point position, and a hardware module for executing the algorithm. A method for enforcing the convex-polygon boundary is also provided that shapes a velocity control signal via a host machine as a function of the reference point position.

  6. The mechanics of elevation control in locust jumping.

    PubMed

    Sutton, G P; Burrows, M

    2008-06-01

    How do animals control the trajectory of ballistic motions like jumping? Targeted jumps by a locust, which are powered by a rapid extension of the tibiae of both hind legs, require control of the take-off angle and speed. To determine how the locust controls these parameters, we used high speed images of jumps and mechanical analysis to reach three conclusions: (1) the extensor tibiae muscle applies equal and opposite torques to the femur and tibia, which ensures that tibial extension accelerates the centre of mass of the body along a straight line; (2) this line is parallel to a line drawn from the distal end of the tibia through the proximal end of the femur; (3) the slope of this line (the angle of elevation) is not affected if the two hind legs extend asynchronously. The mechanics thus uncouple the control of elevation and speed, allowing simplified and independent control mechanisms. Jump elevation is controlled mechanically by the initial positions of the hind legs and jump speed is determined by the energy stored within their elastic processes, which allows us to then propose which proprioceptors are involved in controlling these quantities.

  7. Molecular mechanism of size control in development and human diseases

    PubMed Central

    Yang, Xiaolong; Xu, Tian

    2011-01-01

    How multicellular organisms control their size is a fundamental question that fascinated generations of biologists. In the past 10 years, tremendous progress has been made toward our understanding of the molecular mechanism underlying size control. Original studies from Drosophila showed that in addition to extrinsic nutritional and hormonal cues, intrinsic mechanisms also play important roles in the control of organ size during development. Several novel signaling pathways such as insulin and Hippo-LATS signaling pathways have been identified that control organ size by regulating cell size and/or cell number through modulation of cell growth, cell division, and cell death. Later studies using mammalian cell and mouse models also demonstrated that the signaling pathways identified in flies are also conserved in mammals. Significantly, recent studies showed that dysregulation of size control plays important roles in the development of many human diseases such as cancer, diabetes, and hypertrophy. PMID:21483452

  8. Pressure versus volume controlled modes in invasive mechanical ventilation.

    PubMed

    Garnero, A J; Abbona, H; Gordo-Vidal, F; Hermosa-Gelbard, C

    2013-05-01

    The first generation of mechanical ventilators were controlled and cycled by pressure. Unfortunately, they did not allow control of the delivered tidal volume under changes in the dynamics of the respiratory system. This led to a second generation of ventilators that allowed volume control, hence favoring the ventilatory strategy based on normalization of the arterial gases. Studies conducted in the 1980s which related lung injury to the high ventilator pressures utilized while treating acute respiratory distress syndrome patients renewed interest in pressure-controlled mechanical ventilation. In addition, new evidence became available, leading to the development of pulmonary protective strategies aiming at preventing the progression of ventilator-induced lung injury. This review provides a detailed description of the control of pressure or volume using certain ventilatory modes, and offers a general view of their advantages and disadvantages, based on the latest available evidence.

  9. Pressure versus volume controlled modes in invasive mechanical ventilation.

    PubMed

    Garnero, A J; Abbona, H; Gordo-Vidal, F; Hermosa-Gelbard, C

    2013-05-01

    The first generation of mechanical ventilators were controlled and cycled by pressure. Unfortunately, they did not allow control of the delivered tidal volume under changes in the dynamics of the respiratory system. This led to a second generation of ventilators that allowed volume control, hence favoring the ventilatory strategy based on normalization of the arterial gases. Studies conducted in the 1980s which related lung injury to the high ventilator pressures utilized while treating acute respiratory distress syndrome patients renewed interest in pressure-controlled mechanical ventilation. In addition, new evidence became available, leading to the development of pulmonary protective strategies aiming at preventing the progression of ventilator-induced lung injury. This review provides a detailed description of the control of pressure or volume using certain ventilatory modes, and offers a general view of their advantages and disadvantages, based on the latest available evidence. PMID:23260264

  10. Growth Control and Disease Mechanisms in Computational Embryogeny

    NASA Technical Reports Server (NTRS)

    Shapiro, Andrew A.; Yogev, Or; Antonsson, Erik K.

    2008-01-01

    This paper presents novel approach to applying growth control and diseases mechanisms in computational embryogeny. Our method, which mimics fundamental processes from biology, enables individuals to reach maturity in a controlled process through a stochastic environment. Three different mechanisms were implemented; disease mechanisms, gene suppression, and thermodynamic balancing. This approach was integrated as part of a structural evolutionary model. The model evolved continuum 3-D structures which support an external load. By using these mechanisms we were able to evolve individuals that reached a fixed size limit through the growth process. The growth process was an integral part of the complete development process. The size of the individuals was determined purely by the evolutionary process where different individuals matured to different sizes. Individuals which evolved with these characteristics have been found to be very robust for supporting a wide range of external loads.

  11. Mechanisms for control of biological electron transfer reactions

    PubMed Central

    Williamson, Heather R.; Dow, Brian A.; Davidson, Victor L.

    2014-01-01

    Electron transfer (ET) through and between proteins is a fundamental biological process. The rates and mechanisms of these ET reactions are controlled by the proteins in which the redox centers that donate and accept electrons reside. The protein influences the magnitudes of the ET parameters, the electronic coupling and reorganization energy that are associated with the ET reaction. The protein can regulate the rates of the ET reaction by requiring reaction steps to optimize the system for ET, leading to kinetic mechanisms of gated or coupled ET. Amino acid residues in the segment of the protein through which long range ET occurs can also modulate the ET rate by serving as staging points for hopping mechanisms of ET. Specific examples are presented to illustrate these mechanisms by which proteins control rates of ET reactions. PMID:25085775

  12. Rock mechanics. Superplastic nanofibrous slip zones control seismogenic fault friction.

    PubMed

    Verberne, Berend A; Plümper, Oliver; de Winter, D A Matthijs; Spiers, Christopher J

    2014-12-12

    Understanding the internal mechanisms controlling fault friction is crucial for understanding seismogenic slip on active faults. Displacement in such fault zones is frequently localized on highly reflective (mirrorlike) slip surfaces, coated with thin films of nanogranular fault rock. We show that mirror-slip surfaces developed in experimentally simulated calcite faults consist of aligned nanogranular chains or fibers that are ductile at room conditions. These microstructures and associated frictional data suggest a fault-slip mechanism resembling classical Ashby-Verrall superplasticity, capable of producing unstable fault slip. Diffusive mass transfer in nanocrystalline calcite gouge is shown to be fast enough for this mechanism to control seismogenesis in limestone terrains. With nanogranular fault surfaces becoming increasingly recognized in crustal faults, the proposed mechanism may be generally relevant to crustal seismogenesis.

  13. COAXIAL CONTROL ROD DRIVE MECHANISM FOR NEUTRONIC REACTORS

    DOEpatents

    Fox, R.J.; Oakes, L.C.

    1959-04-14

    A drive mechanism is presented for the control rod or a nuclear reactor. In this device the control rod is coupled to a drive shaft which extends coaxially through the rotor of an electric motor for relative rotation with respect thereto. A gear reduction mehanism is coupled between the rotor and the drive shaft to convert the rotary motion of the motor into linear motion of the shaft with a comparatively great reduction in speed, thereby providing relatively glow linear movement of the shaft and control rod for control purposes.

  14. Development of Ti-Nb-Zr alloys with high elastic admissible strain for temporary orthopedic devices.

    PubMed

    Ozan, Sertan; Lin, Jixing; Li, Yuncang; Ipek, Rasim; Wen, Cuie

    2015-07-01

    A new series of beta Ti-Nb-Zr (TNZ) alloys with considerable plastic deformation ability during compression test, high elastic admissible strain, and excellent cytocompatibility have been developed for removable bone tissue implant applications. TNZ alloys with nominal compositions of Ti-34Nb-25Zr, Ti-30Nb-32Zr, Ti-28Nb-35.4Zr and Ti-24.8Nb-40.7Zr (wt.% hereafter) were fabricated using the cold-crucible levitation technique, and the effects of alloying element content on their microstructures, mechanical properties (tensile strength, yield strength, compressive yield strength, Young's modulus, elastic energy, toughness, and micro-hardness), and cytocompatibilities were investigated and compared. Microstructural examinations revealed that the TNZ alloys consisted of β phase. The alloy samples displayed excellent ductility with no cracking, or fracturing during compression tests. Their tensile strength, Young's modulus, elongation at rupture, and elastic admissible strain were measured in the ranges of 704-839 MPa, 62-65 GPa, 9.9-14.8% and 1.08-1.31%, respectively. The tensile strength, Young's modulus and elongation at rupture of the Ti-34Nb-25Zr alloy were measured as 839 ± 31.8 MPa, 62 ± 3.6 GPa, and 14.8 ± 1.6%, respectively; this alloy exhibited the elastic admissible strain of approximately 1.31%. Cytocompatibility tests indicated that the cell viability ratios (CVR) of the alloys are greater than those of the control group; thus the TNZ alloys possess excellent cytocompatibility.

  15. Admissions to Detoxification after Treatment: Does Engagement Make a Difference?

    PubMed Central

    Acevedo, Andrea; Garnick, Deborah; Ritter, Grant; Lundgren, Lena; Horgan, Constance

    2015-01-01

    Background Treatment engagement is a well-established performance measure for the treatment of substance use disorders. This study examined whether outpatient treatment engagement is associated with a reduced likelihood of subsequent detoxification admissions. Methods This study used administrative data on treatment services received by clients in specialty treatment facilities licensed in Massachusetts. The sample consisted of 11,591 adult clients who began an outpatient treatment episode in 2006. Treatment engagement was defined as receipt of at least one treatment service within 14 days of beginning a new outpatient treatment episode and receipt of at least two additional treatment services in the next 30 days. The outcome was a subsequent detoxification admission. Multilevel survival models examined the relationship between engagement and outcomes, with time to detoxification admission as the dependent variable censored at 365 days. Results Only 35% of clients met the outpatient engagement criteria and 15% of clients had a detoxification admission within a year after beginning their outpatient treatment episode. Controlling for client demographics, insurance type, and substance use severity, clients who met the engagement criteria had a lower hazard of having a detoxification admission during the year following the index outpatient visit than those who did not engage (Hazard Ratio = 0.87, p < .01). Conclusions Treatment engagement is a useful measure for monitoring quality of care. The findings from this study could help inform providers and policy makers on ways to target care and reduce the likelihood of more intensive services. PMID:26308604

  16. Mechanical Response of DNA–Nanoparticle Crystals to Controlled Deformation

    PubMed Central

    2016-01-01

    The self-assembly of DNA-conjugated nanoparticles represents a promising avenue toward the design of engineered hierarchical materials. By using DNA to encode nanoscale interactions, macroscale crystals can be formed with mechanical properties that can, at least in principle, be tuned. Here we present in silico evidence that the mechanical response of these assemblies can indeed be controlled, and that subtle modifications of the linking DNA sequences can change the Young’s modulus from 97 kPa to 2.1 MPa. We rely on a detailed molecular model to quantify the energetics of DNA–nanoparticle assembly and demonstrate that the mechanical response is governed by entropic, rather than enthalpic, contributions and that the response of the entire network can be estimated from the elastic properties of an individual nanoparticle. The results here provide a first step toward the mechanical characterization of DNA–nanoparticle assemblies, and suggest the possibility of mechanical metamaterials constructed using DNA. PMID:27725959

  17. Output feedback control of a mechanical system using magnetic levitation.

    PubMed

    Beltran-Carbajal, F; Valderrabano-Gonzalez, A; Rosas-Caro, J C; Favela-Contreras, A

    2015-07-01

    This paper presents an application of a nonlinear magnetic levitation system to the problem of efficient active control of mass-spring-damper mechanical systems. An output feedback control scheme is proposed for reference position trajectory tracking tasks on the flexible mechanical system. The electromagnetically actuated system is shown to be a differentially flat nonlinear system. An extended state estimation approach is also proposed to obtain estimates of velocity, acceleration and disturbance signals. The differential flatness structural property of the system is then employed for the synthesis of the controller and the signal estimation approach presented in this work. Some experimental and simulation results are included to show the efficient performance of the control approach and the effective estimation of the unknown signals.

  18. Output feedback control of a mechanical system using magnetic levitation.

    PubMed

    Beltran-Carbajal, F; Valderrabano-Gonzalez, A; Rosas-Caro, J C; Favela-Contreras, A

    2015-07-01

    This paper presents an application of a nonlinear magnetic levitation system to the problem of efficient active control of mass-spring-damper mechanical systems. An output feedback control scheme is proposed for reference position trajectory tracking tasks on the flexible mechanical system. The electromagnetically actuated system is shown to be a differentially flat nonlinear system. An extended state estimation approach is also proposed to obtain estimates of velocity, acceleration and disturbance signals. The differential flatness structural property of the system is then employed for the synthesis of the controller and the signal estimation approach presented in this work. Some experimental and simulation results are included to show the efficient performance of the control approach and the effective estimation of the unknown signals. PMID:25707718

  19. Mechanisms of active control in cylindrical fuselage structures

    NASA Technical Reports Server (NTRS)

    Silcox, R. J.; Lester, H. C.; Fuller, C. R.

    1987-01-01

    This paper summarizes ongoing efforts to understand and exploit active control techniques for low frequency noise suppression in aerospace applications. Analytical models are utilized in an effort to understand the mechanisms that govern noise transmission into acoustic spaces enclosed by lightweight structures and to examine the results of experimental implementations of active control schemes. Emphasis is placed on attaining global noise reductions using a minimum number of actuators rather than localized control over many subregions. This program has demonstrated the effect of synchrophasing and interface modal filtering, in limiting the modal density within the acoustic space, and how strong reactive effects may occur in two dimensional geometries. Finally, the performance of active control systems utilizing acoustic and vibration actuators is evaluated. Suppressions of 10 to 30 dB are demonstrated in practice, and performance is discussed in relation to the physical mechanisms and parameters of the system.

  20. Tuberculosis in hospitalized patients: clinical characteristics of patients receiving treatment within the first 24 h after admission*

    PubMed Central

    Silva, Denise Rossato; da Silva, Larissa Pozzebon; Dalcin, Paulo de Tarso Roth

    2014-01-01

    Objective: To evaluate clinical characteristics and outcomes in patients hospitalized for tuberculosis, comparing those in whom tuberculosis treatment was started within the first 24 h after admission with those who did not. Methods: This was a retrospective cohort study involving new tuberculosis cases in patients aged ≥ 18 years who were hospitalized after seeking treatment in the emergency room. Results: We included 305 hospitalized patients, of whom 67 (22.0%) received tuberculosis treatment within the first 24 h after admission ( ≤24h group) and 238 (88.0%) did not (>24h group). Initiation of tuberculosis treatment within the first 24 h after admission was associated with being female (OR = 1.99; 95% CI: 1.06-3.74; p = 0.032) and with an AFB-positive spontaneous sputum smear (OR = 4.19; 95% CI: 1.94-9.00; p < 0.001). In the ≤24h and >24h groups, respectively, the ICU admission rate was 22.4% and 15.5% (p = 0.258); mechanical ventilation was used in 22.4% and 13.9% (p = 0.133); in-hospital mortality was 22.4% and 14.7% (p = 0.189); and a cure was achieved in 44.8% and 52.5% (p = 0.326). Conclusions: Although tuberculosis treatment was initiated promptly in a considerable proportion of the inpatients evaluated, the rates of in-hospital mortality, ICU admission, and mechanical ventilation use remained high. Strategies for the control of tuberculosis in primary care should consider that patients who seek medical attention at hospitals arrive too late and with advanced disease. It is therefore necessary to implement active surveillance measures in the community for earlier diagnosis and treatment. PMID:25029651

  1. Designing Crane Controls with applied Mechanical and Electrical Safety Features

    NASA Technical Reports Server (NTRS)

    Lytle, Bradford P.; Walczak, Thomas A.; Delgado, H. (Technical Monitor)

    2002-01-01

    The use of overhead traveling bridge cranes in many varied applications is common practice. In particular, the use of cranes in the nuclear, military, commercial, aerospace, and other industries can involve safety critical situations. Considerations for Human Injury or Casualty, Loss of Assets, Endangering the Environment, or Economic Reduction must be addressed. Traditionally, in order to achieve additional safety in these applications, mechanical systems have been augmented with a variety of devices. These devices assure that a mechanical component failure shall reduce the risk of a catastrophic loss of the correct and/or safe load carrying capability. ASME NOG-1-1998, (Rules for Construction of Overhead and Gantry Cranes, Top Running Bridge, and Multiple Girder), provides design standards for cranes in safety critical areas. Over and above the minimum safety requirements of todays design standards, users struggle with obtaining a higher degree of reliability through more precise functional specifications while attempting to provide "smart" safety systems. Electrical control systems also may be equipped with protective devices similar to the mechanical design features. Demands for improvement of the cranes "control system" is often recognized, but difficult to quantify for this traditionally "mechanically" oriented market. Finite details for each operation must be examined and understood. As an example, load drift (or small motions) at close tolerances can be unacceptable (and considered critical). To meet these high functional demands encoders and other devices are independently added to control systems to provide motion and velocity feedback to the control drive. This paper will examine the implementation of Programmable Electronic Systems (PES). PES is a term this paper will use to describe any control system utilizing any programmable electronic device such as Programmable Logic Controllers (PLC), or an Adjustable Frequency Drive (AID) 'smart' programmable

  2. 40 CFR 85.1505 - Final admission of certified vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 19 2013-07-01 2013-07-01 false Final admission of certified vehicles. 85.1505 Section 85.1505 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and...

  3. 40 CFR 85.1505 - Final admission of certified vehicles.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 19 2014-07-01 2014-07-01 false Final admission of certified vehicles. 85.1505 Section 85.1505 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and...

  4. 40 CFR 85.1505 - Final admission of certified vehicles.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 19 2012-07-01 2012-07-01 false Final admission of certified vehicles. 85.1505 Section 85.1505 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and...

  5. 40 CFR 85.1505 - Final admission of certified vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Final admission of certified vehicles. 85.1505 Section 85.1505 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and...

  6. 40 CFR 85.1505 - Final admission of certified vehicles.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Final admission of certified vehicles. 85.1505 Section 85.1505 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CONTROL OF AIR POLLUTION FROM MOBILE SOURCES Importation of Motor Vehicles and...

  7. 9. Detail of the rack and pinion control gate mechanism ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Detail of the rack and pinion control gate mechanism on the intake structure for the Niagara Mohawk Power Corporatation no.2 unit at the southeast end of the dam. Facing northwest. - Glens Falls Dam, 100' to 450' West of U.S. Route 9 Bridge Spanning Hudson River, Glens Falls, Warren County, NY

  8. Fluid Mechanics of Wing Adaptation for Separation Control

    NASA Technical Reports Server (NTRS)

    Chandrasekhara, M. S.; Wilder, M. C.; Carr, L. W.; Davis, Sanford S. (Technical Monitor)

    1997-01-01

    The unsteady fluid mechanics associated with use of a dynamically deforming leading edge airfoil for achieving compressible flow separation control has been experimentally studied. Changing the leading edge curvature at rapid rates dramatically alters the flow vorticity dynamics which is responsible for the many effects observed in the flow.

  9. 6. GOVERNOR AND SPEED CONTROL MECHANISMS TANK, AT LEFT AN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. GOVERNOR AND SPEED CONTROL MECHANISMS TANK, AT LEFT AN ACCUMULATOR TANK WHICH STORE AIR PRESSURE TO OPEN GATES AND GET GENERATOR STARTED. LARGE TANK AT RIGHT IS THE MAIN GUARD VALVE FOR THE GENERATOR - Los Angeles Aqueduct, Haiwee Power Plant, Los Angeles, Los Angeles County, CA

  10. Obesity, mechanical and strength relationships to postural control in adolescence.

    PubMed

    King, Adam C; Challis, John H; Bartok, Cynthia; Costigan, F Aileen; Newell, Karl M

    2012-02-01

    There is preliminary evidence that BMI is positively correlated with movement variability of standing posture. However, this negative effect of obesity on postural control may be mediated by the change in other body scale variables (e.g., mechanical and fitness) that also occur with changes in BMI. This study investigated the influence of selected body scale (height, body mass, BMI), body composition (body fat percentage), mechanical (moment of inertia - MI) and strength (S) variables as predictors of the control of postural motion in adolescents. 125 healthy adolescents (65 boys, 60 girls) with a wide range of BMI (13.8-31.0 kg/m(2)) performed a battery of tests that assessed body composition, anthropometry, muscular strength and postural control. Multiple measures of postural motion variability were derived for analysis with body scale, mechanical and lower extremity strength variables separately for boys and girls. BMI, height and body mass, considered both separately and collectively, were poor and/or inconsistent predictors of variability in all three posture tasks. However, the ratio of lower extremity strength to whole body moment of inertia showed the highest positive correlation to most postural variability measures in both boys and girls and these effects were strongest in the less stable tasks of single leg standing and recovery of stance. Our findings support the hypothesis that diminished lower extremity strength to mechanical constraint ratio compromises the robustness of the strength to body scale relation in movement and postural control. PMID:22018701

  11. Quasivelocities and Optimal Control for underactuated Mechanical Systems

    NASA Astrophysics Data System (ADS)

    Colombo, L.; de Diego, D. Martín

    2010-07-01

    This paper is concerned with the application of the theory of quasivelocities for optimal control for underactuated mechanical systems. Using this theory, we convert the original problem in a variational second-order lagrangian system subjected to constraints. The equations of motion are geometrically derived using an adaptation of the classical Skinner and Rusk formalism.

  12. Context-Based E-Health System Access Control Mechanism

    NASA Astrophysics Data System (ADS)

    Al-Neyadi, Fahed; Abawajy, Jemal H.

    E-Health systems logically demand a sufficiently fine-grained authorization policy for access control. The access to medical information should not be just role-based but should also include the contextual condition of the role to access data. In this paper, we present a mechanism to extend the standard role-based access control to incorporate contextual information for making access control decisions in e-health application. We present an architecture consisting of authorisation and context infrastructure that work cooperatively to grant access rights based on context-aware authorization policies and context information.

  13. Counting the cost of diabetic hospital admissions from a multi-ethnic population in Trinidad.

    PubMed

    Gulliford, M C; Ariyanayagam-Baksh, S M; Bickram, L; Picou, D; Mahabir, D

    1995-12-01

    Many middle-income countries are experiencing an increase in diabetes mellitus but patterns of morbidity and resource use from diabetes in developing countries have not been well described. We evaluated hospital admission with diabetes among different ethnic groups in Trinidad. We compiled a register of all patients with diabetes admitted to adult medical, general surgical, and ophthalmology wards at Port of Spain Hospital, Trinidad. During 26 weeks, 1447 patients with diabetes had 1722 admissions. Annual admission rates, standardized to the World Population, for the catchment population aged 30-64 years were 1031 (95% CI 928 to 1134) per 100,000 in men and 1354 (1240 to 1468) per 100,000 in women. Compared with the total population, admission rates were 33% higher in the Indian origin population and 47% lower in those of mixed ethnicity. The age-standardized rate of amputation with diabetes in the general population aged 30-64 years was 54 (37 to 71) per 100,000. The hospital admission fatality rate was 8.9% (95%CI 7.6% to 10.2%). Mortality was associated with increasing age, admission with hyperglycaemia, elevated serum creatinine, cardiac failure or stroke and with lower-limb amputation during admission. Diabetes accounted for 13.6% of hospital admissions and 23% of hospital bed occupancy. Admissions associated with disorders of blood glucose control or foot problems accounted for 52% of diabetic hospital bed occupancy. The annual cost of admissions with diabetes was conservatively estimated at TT+ 10.66 million (UK 1.24 million pounds). In this community diabetes admission rates were high and varied according to the prevalence of diabetes. Admissions, fatalities and resource use were associated with acute and chronic complications of diabetes. Investing in better quality preventive clinical care for diabetes might provide an economically advantageous policy for countries like Trinidad and Tobago.

  14. Underlying mechanisms in size control of uniform nanoparticles.

    PubMed

    Sugimoto, Tadao

    2007-05-01

    Insights are given into underlying mechanisms for size control of uniform nanoparticles in liquid phases. At the outset, instead of the classical nucleation theories, which are hardly applicable to the size control of uniform particles, a fundamental equation for the nucleation of monodisperse particles, derived for their size control on the basis of the LaMer model, is introduced. This equation was derived on three assumptions: (1) There is a mass balance between the supply rate of solute and its consumption rate for nucleation and growth of the generated nuclei; (2) The supply rate of solute is independent of the subsequent precipitation events; (3) The nucleation rate is controlled only by the growth of the preformed nuclei at a fixed supply rate of solute. Thus, this nucleation theory is applicable to a system in which the precursor solute is supplied by slow irreversible generation in a closed system or by continuous feed from outside in an open system. However, it is inapplicable even if only one of these three assumptions is not fulfilled. Examples of applicable and inapplicable systems are listed, and finally discussion is focused on the underlying mechanisms of size control in some unique processes chosen from them, such as hydrolysis-induced precipitation of AgCl nanoparticles, double-jet precipitation of AgCl nanoparticles in a reverse micelle system to resolve the mechanism of particle formation in general reverse micelle systems, and a gel-sol process for the formation of nanoparticles of anatase TiO2.

  15. Topology of optimally controlled quantum mechanical transition probability landscapes

    SciTech Connect

    Rabitz, H.; Ho, T.-S.; Hsieh, M.; Kosut, R.; Demiralp, M.

    2006-07-15

    An optimally controlled quantum system possesses a search landscape defined by the physical objective as a functional of the control field. This paper particularly explores the topological structure of quantum mechanical transition probability landscapes. The quantum system is assumed to be controllable and the analysis is based on the Euler-Lagrange variational equations derived from a cost function only requiring extremizing the transition probability. It is shown that the latter variational equations are automatically satisfied as a mathematical identity for control fields that either produce transition probabilities of zero or unit value. Similarly, the variational equations are shown to be inconsistent (i.e., they have no solution) for any control field that produces a transition probability different from either of these two extreme values. An upper bound is shown to exist on the norm of the functional derivative of the transition probability with respect to the control field anywhere over the landscape. The trace of the Hessian, evaluated for a control field producing a transition probability of a unit value, is shown to be bounded from below. Furthermore, the Hessian at a transition probability of unit value is shown to have an extensive null space and only a finite number of negative eigenvalues. Collectively, these findings show that (a) the transition probability landscape extrema consists of values corresponding to no control or full control, (b) approaching full control involves climbing a gentle slope with no false traps in the control space and (c) an inherent degree of robustness exists around any full control solution. Although full controllability may not exist in some applications, the analysis provides a basis to understand the evident ease of finding controls that produce excellent yields in simulations and in the laboratory.

  16. Active vibration control using mechanical and electrical analogies

    NASA Astrophysics Data System (ADS)

    Torres-Perez, A.; Hassan, A.; Kaczmarczyk, S.; Picton, P.

    2016-05-01

    Mechanical-electrical analogous circuit models are widely used in electromechanical system design as they represent the function of a coupled electrical and mechanical system using an equivalent electrical system. This research uses electrical circuits to establish a discussion of simple active vibration control principles using two scenarios: an active vibration isolation system and an active dynamic vibration absorber (DVA) using a voice coil motor (VCM) actuator. Active control laws such as gain scheduling are intuitively explained using circuit analysis techniques. Active vibration control approaches are typically constraint by electrical power requirements. The electrical analogous is a fast approach for specifying power requirements on the experimental test platform which is based on a vibration shaker that provides the based excitation required for the single Degree- of-Freedom (1DoF) vibration model under study.

  17. Robust control of multi-jointed arm with a decentralized autonomous control mechanism

    NASA Technical Reports Server (NTRS)

    Kimura, Shinichi; Miyazaki, Ken; Suzuki, Yoshiaki

    1994-01-01

    A decentralized autonomous control mechanism applied to the control of three dimensional manipulators and its robustness to partial damage was assessed by computer simulation. Decentralized control structures are believed to be quite robust to time delay between the operator and the target system. A 10-jointed manipulator based on our control mechanism was able to continue its positioning task in three-dimensional space without revision of the control program, even after some of its joints were damaged. These results suggest that this control mechanism can be effectively applied to space telerobots, which are associated with serious time delay between the operator and the target system, and which cannot be easily repaired after being partially damaged.

  18. Overview: Mechanism and Control of a Prosthetic Arm.

    PubMed

    Kulkarni, Tushar; Uddanwadiker, Rashmi

    2015-09-01

    Continuous growth in industrialization and lack of awareness in safety parameters the cases of amputations are growing. The search of safer, simpler and automated prosthetic arms for managing upper limbs is expected. Continuous efforts have been made to design and develop prosthetic arms ranging from simple harness actuated to automated mechanisms with various control options. However due the cost constraints, the automated prosthetic arms are still out of the reach of needy people. Recent data have shown that there is a wide scope to develop a low cost and light weight upper limb prosthesis. This review summarizes the various designs methodologies, mechanisms and control system developed by the researchers and the advances therein. Educating the patient to develop acceptability to prosthesis and using the same for the most basic desired functions of human hand, post amputation care and to improve patient's independent life is equally important. In conclusion it can be interpreted that there is a wide scope in design in an adaptive mechanism for opening and closing of the fingers using other methods of path and position synthesis. Simple mechanisms and less parts may optimize the cost factor. Reduction in the weight of the prosthesis may be achieved using polymers used for engineering applications. Control system will remain never ending challenge for the researchers, but it is essential to maintain the simplicity from the patients perspective. PMID:27281955

  19. Adaptive mechanism-based congestion control for networked systems

    NASA Astrophysics Data System (ADS)

    Liu, Zhi; Zhang, Yun; Chen, C. L. Philip

    2013-03-01

    In order to assure the communication quality in network systems with heavy traffic and limited bandwidth, a new ATRED (adaptive thresholds random early detection) congestion control algorithm is proposed for the congestion avoidance and resource management of network systems. Different to the traditional AQM (active queue management) algorithms, the control parameters of ATRED are not configured statically, but dynamically adjusted by the adaptive mechanism. By integrating with the adaptive strategy, ATRED alleviates the tuning difficulty of RED (random early detection) and shows a better control on the queue management, and achieve a more robust performance than RED under varying network conditions. Furthermore, a dynamic transmission control protocol-AQM control system using ATRED controller is introduced for the systematic analysis. It is proved that the stability of the network system can be guaranteed when the adaptive mechanism is finely designed. Simulation studies show the proposed ATRED algorithm achieves a good performance in varying network environments, which is superior to the RED and Gentle-RED algorithm, and providing more reliable service under varying network conditions.

  20. Admission avoidance and early discharge of acute hospital admissions: an accident and emergency based scheme

    PubMed Central

    Hardy, C; Whitwell, D; Sarsfield, B; Maimaris, C

    2001-01-01

    Objectives—To validate an accident and emergency (A&E) based approach to assisting early discharge or avoiding admission to acute hospital beds by means of two separate teams, one in hospital and the other in the community, working closely together at the interface between primary and secondary health care. Design—A purpose designed admission avoidance (AA) team was established in the A&E department, and a target group of patients identified whose admissions might be avoided or curtailed. A rapid response community team (RRCT) based in Cambridge was also established to provide basic health care to patients in their homes after discharge from hospital. The key elements of the project were rapid assessment, careful selection of patients, early decision making at senior level, and close liaison with the community team. Results—During the first year (1999) of the project the AA team assessed 785 patients and 257 patients were eventually discharged home to the care of the RRCT. Of these, 149 patients (58%) were comparable to a historical control group (from 1997/98), with regard to their demographic and clinical characteristics and care needs, and had an average length of hospital stay of 1.7 days compared with 6.3 days for the control group. The remaining 108 patients were not directly comparable but were supported by the teams because the benefits were clear and exclusion would have been unethical. These patients had an average length of stay of seven days. The readmission rate was 3 of 257(1.2%) for the intervention group and 8 of 531(1.5%) for the control group. A limited patient satisfaction survey among patients cared for at home revealed that 97% of patients were "satisfied to very satisfied" with the care provided. The RRCT had also looked after an additional 194 patients from other sources (total = 451), including postoperative orthopaedic early discharges from an adjacent hospital. The average length of care at home by the RRCT for all 451 patients was 6

  1. Potential Mechanisms of Cancer Prevention by Weight Control

    NASA Astrophysics Data System (ADS)

    Jiang, Yu; Wang, Weiqun

    Weight control via dietary caloric restriction and/or physical activity has been demonstrated in animal models for cancer prevention. However, the underlying mechanisms are not fully understood. Body weight loss due to negative energy balance significantly reduces some metabolic growth factors and endocrinal hormones such as IGF-1, leptin, and adiponectin, but enhances glucocorticoids, that may be associated with anti-cancer mechanisms. In this review, we summarized the recent studies related to weight control and growth factors. The potential molecular targets focused on those growth factors- and hormones-dependent cellular signaling pathways are further discussed. It appears that multiple factors and multiple signaling cascades, especially for Ras-MAPK-proliferation and PI3K-Akt-anti-apoptosis, could be involved in response to weight change by dietary calorie restriction and/or exercise training. Considering prevalence of obesity or overweight that becomes apparent over the world, understanding the underlying mechanisms among weight control, endocrine change and cancer risk is critically important. Future studies using "-omics" technologies will be warrant for a broader and deeper mechanistic information regarding cancer prevention by weight control.

  2. Altered neuromuscular control mechanisms of the trapezius muscle in fibromyalgia

    PubMed Central

    2010-01-01

    Background fibromyalgia is a relatively common condition with widespread pain and pressure allodynia, but unknown aetiology. For decades, the association between motor control strategies and chronic pain has been a topic for debate. One long held functional neuromuscular control mechanism is differential activation between regions within a single muscle. The aim of this study was to investigate differences in neuromuscular control, i.e. differential activation, between myalgic trapezius in fibromyalgia patients and healthy controls. Methods 27 fibromyalgia patients and 30 healthy controls performed 3 minutes bilateral shoulder elevations with different loads (0-4 Kg) with a high-density surface electromyographical (EMG) grid placed above the upper trapezius. Differential activation was quantified by the power spectral median frequency of the difference in EMG amplitude between the cranial and caudal parts of the upper trapezius. The average duration of the differential activation was described by the inverse of the median frequency of the differential activations. Results the median frequency of the differential activations was significantly lower, and the average duration of the differential activations significantly longer in fibromyalgia compared with controls at the two lowest load levels (0-1 Kg) (p < 0.04), but not at the two highest load levels (2 and 4 Kg). Conclusion these findings illustrate a different neuromuscular control between fibromyalgia patients and healthy controls during a low load functional task, either sustaining or resulting from the chronic painful condition. The findings may have clinical relevance for rehabilitation strategies for fibromyalgia. PMID:20205731

  3. Dynamic Inversion based Control of a Docking Mechanism

    NASA Technical Reports Server (NTRS)

    Kulkarni, Nilesh V.; Ippolito, Corey; Krishnakumar, Kalmanje

    2006-01-01

    The problem of position and attitude control of the Stewart platform based docking mechanism is considered motivated by its future application in space missions requiring the autonomous docking capability. The control design is initiated based on the framework of the intelligent flight control architecture being developed at NASA Ames Research Center. In this paper, the baseline position and attitude control system is designed using dynamic inversion with proportional-integral augmentation. The inverse dynamics uses a Newton-Euler formulation that includes the platform dynamics, the dynamics of the individual legs along with viscous friction in the joints. Simulation results are presented using forward dynamics simulated by a commercial physics engine that builds the system as individual elements with appropriate joints and uses constrained numerical integration,

  4. Analysis of femtosecond quantum control mechanisms with colored double pulses

    SciTech Connect

    Vogt, Gerhard; Nuernberger, Patrick; Selle, Reimer; Dimler, Frank; Brixner, Tobias; Gerber, Gustav

    2006-09-15

    Fitness landscapes based on a limited number of laser pulse shape parameters can elucidate reaction pathways and can help to find the underlying control mechanism of optimal pulses determined by adaptive femtosecond quantum control. In a first experiment, we employ colored double pulses and systematically scan both the temporal subpulse separation and the relative amplitude of the two subpulses to acquire fitness landscapes. Comparison with results obtained from a closed-loop experiment demonstrates the capability of fitness landscapes for the revelation of possible control mechanisms. In a second experiment, using transient absorption spectroscopy, we investigate and compare the dependence of the excitation efficiency of the solvated dye molecule 5,5{sup '}-dichloro-11-diphenylamino-3,3{sup '}-diethyl-10,12-ethylene thiatricarbocyanine perchlorate (IR140) on selected pulse shapes in two parametrizations. The results show that very different pulse profiles can be equivalently adequate to maximize a given control objective. Fitness landscapes thus provide valuable information about different pathways along which a molecular system can be controlled with shaped laser pulses.

  5. Mechanisms of abscisic acid-mediated control of stomatal aperture.

    PubMed

    Munemasa, Shintaro; Hauser, Felix; Park, Jiyoung; Waadt, Rainer; Brandt, Benjamin; Schroeder, Julian I

    2015-12-01

    Drought stress triggers an increase in the level of the plant hormone abscisic acid (ABA), which initiates a signaling cascade to close stomata and reduce water loss. Recent studies have revealed that guard cells control cytosolic ABA concentration through the concerted actions of biosynthesis, catabolism as well as transport across membranes. Substantial progress has been made at understanding the molecular mechanisms of how the ABA signaling core module controls the activity of anion channels and thereby stomatal aperture. In this review, we focus on our current mechanistic understanding of ABA signaling in guard cells including the role of the second messenger Ca(2+) as well as crosstalk with biotic stress responses. PMID:26599955

  6. Optimal control of underactuated mechanical systems: A geometric approach

    NASA Astrophysics Data System (ADS)

    Colombo, Leonardo; Martín De Diego, David; Zuccalli, Marcela

    2010-08-01

    In this paper, we consider a geometric formalism for optimal control of underactuated mechanical systems. Our techniques are an adaptation of the classical Skinner and Rusk approach for the case of Lagrangian dynamics with higher-order constraints. We study a regular case where it is possible to establish a symplectic framework and, as a consequence, to obtain a unique vector field determining the dynamics of the optimal control problem. These developments will allow us to develop a new class of geometric integrators based on discrete variational calculus.

  7. Mechanisms in Adaptive Feedback Control: Photoisomerization in a Liquid

    SciTech Connect

    Hoki, Kunihito; Brumer, Paul

    2005-10-14

    The underlying mechanism for Adaptive Feedback Control in the experimental photoisomerization of 3,3'-diethyl-2,2'-thiacyanine iodide (NK88) in methanol is exposed theoretically. With given laboratory limitations on laser output, the complicated electric fields are shown to achieve their targets in qualitatively simple ways. Further, control over the cis population without laser limitations reveals an incoherent pump-dump scenario as the optimal isomerization strategy. In neither case are there substantial contributions from quantum multiple-path interference or from nuclear wave packet coherence. Environmentally induced decoherence is shown to justify the use of a simplified theoretical model.

  8. Mechanization and Control Concepts for Biologically Inspired Micro Aerial Vehicles

    NASA Technical Reports Server (NTRS)

    Raney, David L.; Slominski, Eric C.

    2003-01-01

    It is possible that MAV designs of the future will exploit flapping flight in order to perform missions that require extreme agility, such as rapid flight beneath a forest canopy or within the confines of a building. Many of nature's most agile flyers generate flapping motions through resonant excitation of an aeroelastically tailored structure: muscle tissue is used to excite a vibratory mode of their flexible wing structure that creates propulsion and lift. A number of MAV concepts have been proposed that would operate in a similar fashion. This paper describes an ongoing research activity in which mechanization and control concepts with application to resonant flapping MAVs are being explored. Structural approaches, mechanical design, sensing and wingbeat control concepts inspired by hummingbirds, bats and insects are examined. Experimental results from a testbed capable of generating vibratory wingbeat patterns that approximately match those exhibited by hummingbirds in hover, cruise, and reverse flight are presented.

  9. Recent Trends in Advance Directives at Nursing Home Admission and One Year after Admission

    ERIC Educational Resources Information Center

    McAuley, William J.; Buchanan, Robert J.; Travis, Shirley S.; Wang, Suojin; Kim, MyungSuk

    2006-01-01

    Purpose: Advance directives are important planning and decision-making tools for individuals in nursing homes. Design and Methods: By using the nursing facility Minimum Data Set, we examined the prevalence of advance directives at admission and 12 months post-admission. Results: The prevalence of having any advance directive at admission declined…

  10. Controlled release mechanisms of spontaneously forming unilamellar vesicles.

    PubMed

    Nieh, Mu-Ping; Katsaras, John; Qi, Xiaoyang

    2008-06-01

    Spontaneously forming small unilamellar vesicles (SULVs) are easy to prepare and show great promise for use in delivering therapeutic payloads. We report of SULVs made up of the ternary phospholipid mixture, dimyristoyl-phosphatidylcholine (DMPC), dihexanoyl-phosphatidylcholine (DHPC) and dimyristoyl-phosphatidylglycerol (DMPG), which have been characterized by small angle neutron scattering (SANS). These low-polydispersity (0.14-0.19) SULVs range in size (i.e., radius) from 110 to 215 A and are capable of entrapping, and subsequently releasing, hydrophilic molecules (e.g., fluorescent dyes and quenchers) in a controlled fashion over two different temperature ranges. The low-temperature release mechanism involves the SULVs transforming into discoidal micelles, with an onset temperature (T(o)) of ~32 degrees C, while the high-temperature release mechanism is more gradual, presumably the result of defects formed through the continuous dissolution of DHPC into solution. Both of these mechanisms differ from other, previously reported thermosensitive liposomes. PMID:18394425

  11. Biogeochemical Mechanisms Controlling Reduced Radionuclide Particle Properties and Stability

    SciTech Connect

    Jim K. Fredrickson; John M. Zachara; Matthew J. Marshall; Alex S. Beliaev

    2006-06-01

    Uranium and Technetium are the major risk-driving contaminants at Hanford and other DOE sites. These radionuclides have been shown to be reduced by dissimilatory metal reducing bacteria (DMRB) under anoxic conditions. Laboratory studies have demonstrated that reduction results in the formation of poorly soluble hydrous oxides, UO2(s) and TcO2n?H2O(s), that are believed to limit mobility in the environment. The mechanisms of microbial reduction of U and Tc have been the focus of considerable research in the Environmental Remediation Sciences Program (ERSP). In spite of equal or greater importance in terms of controlling the environmental fate of the contaminants relatively little is known regarding the precipitation mechanism(s), reactivity, persistence, and transport of biogenic UO2(s) and TcO2(s).

  12. Metabolic control of puberty onset: new players, new mechanisms.

    PubMed

    Roa, Juan; García-Galiano, David; Castellano, Juan M; Gaytan, Francisco; Pinilla, Leonor; Tena-Sempere, Manuel

    2010-08-01

    Puberty, as the end-point of a complex series of maturational events affecting the components of the hypothalamic-pituitary-gonadal (HPG) axis, is gated by the state of body energy reserves and sensitive to different metabolic cues; conditions of severe metabolic stress and energy unbalance (from anorexia to morbid obesity) being commonly linked to perturbation of the onset of puberty. In the last two decades, the neuroendocrine mechanisms responsible for the tight coupling between energy homeostasis and puberty onset have begun to be deciphered. These seemingly involve a plethora of metabolic hormones and neuropeptides, which impinge and integrate (mostly) at the hypothalamic centers governing reproduction. Yet, characterization of the mechanisms of action of such regulators (and even their nature and physiological relevance) still remains incomplete. In this review, we will summarize some recent developments in our knowledge of the effects and mechanisms of action of two key metabolic hormones, leptin and ghrelin, in the control of puberty onset. In addition, the roles of the hypothalamic Kiss1 system in the metabolic gating of puberty will be reviewed, with special attention to its regulation by leptin and the recent identification of the putative roles of Crtc1 and mTOR signaling as molecular conduits for the metabolic control of Kiss1 expression. Elucidation of these novel players and regulatory mechanisms will help for a better understanding of the determinants of the timing of puberty, and its eventual alterations in adverse metabolic conditions.

  13. Obstetric admissions to ICUs in Finland: A multicentre study.

    PubMed

    Seppänen, Pia; Sund, Reijo; Roos, Mervi; Unkila, Riitta; Meriläinen, Merja; Helminen, Mika; Ala-Kokko, Tero; Suominen, Tarja

    2016-08-01

    In this study, the objective was to describe and analyse reasons for obstetric admissions to the ICU, severity of illness, level and types of interventions, adverse events and patient outcomes. In a retrospective database study, we identified 291 obstetric patients during pregnancy and puerperium from four Finnish university hospitals. Most were admitted in the post-partum period and hypertensive disorders were the main indications for admissions, followed by obstetric haemorrhage. The median length of stay was 21hours. The most common intervention was blood transfusion and mechanical ventilation was required in nearly one fifth of the patients. Three patients had a prolonged stay and nine had re-admissions. One maternal death was recorded. This study found that severity of illness and organ failure scores describe the obstetric patient as having a good probability of recovery and a short length of stay. However, the obstetric patients reason for admission and their type of delivery were associated with both the severity of illness scores and level of intervention required. Those admitted for non-obstetric reasons and having had a vaginal delivery demonstrated higher severity of illness scores, organ failure scores, and levels of intervention when compared to those admitted for obstetric reasons or those who had delivered by caesarean section. In conclusion, care of these patients can be improved by understanding the severity of illness scores, common ICU interventions and patient outcomes.

  14. Obstetric admissions to ICUs in Finland: A multicentre study.

    PubMed

    Seppänen, Pia; Sund, Reijo; Roos, Mervi; Unkila, Riitta; Meriläinen, Merja; Helminen, Mika; Ala-Kokko, Tero; Suominen, Tarja

    2016-08-01

    In this study, the objective was to describe and analyse reasons for obstetric admissions to the ICU, severity of illness, level and types of interventions, adverse events and patient outcomes. In a retrospective database study, we identified 291 obstetric patients during pregnancy and puerperium from four Finnish university hospitals. Most were admitted in the post-partum period and hypertensive disorders were the main indications for admissions, followed by obstetric haemorrhage. The median length of stay was 21hours. The most common intervention was blood transfusion and mechanical ventilation was required in nearly one fifth of the patients. Three patients had a prolonged stay and nine had re-admissions. One maternal death was recorded. This study found that severity of illness and organ failure scores describe the obstetric patient as having a good probability of recovery and a short length of stay. However, the obstetric patients reason for admission and their type of delivery were associated with both the severity of illness scores and level of intervention required. Those admitted for non-obstetric reasons and having had a vaginal delivery demonstrated higher severity of illness scores, organ failure scores, and levels of intervention when compared to those admitted for obstetric reasons or those who had delivered by caesarean section. In conclusion, care of these patients can be improved by understanding the severity of illness scores, common ICU interventions and patient outcomes. PMID:27209560

  15. Admission to Law School: New Measures

    ERIC Educational Resources Information Center

    Shultz, Marjorie M.; Zedeck, Sheldon

    2012-01-01

    Standardized tests have been increasingly controversial over recent years in high-stakes admission decisions. Their role in operationalizing definitions of merit and qualification is especially contested, but in law schools this challenge has become particularly intense. Law schools have relied on the Law School Admission Test (LSAT) and an INDEX…

  16. Alphabetical Order Effects in School Admissions

    ERIC Educational Resources Information Center

    Jurajda, Štepán; Münich, Daniel

    2016-01-01

    If school admission committees use alphabetically sorted lists of applicants in their evaluations, one's position in the alphabet according to last name initial may be important in determining access to selective schools. Jurajda and Münich (2010) "Admission to Selective Schools, Alphabetically". "Economics of Education…

  17. 43 CFR 41.300 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false Admission. 41.300 Section 41.300 Public Lands: Interior Office of the Secretary of the Interior NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited §...

  18. 15 CFR 8a.300 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Admission. 8a.300 Section 8a.300 Commerce and Foreign Trade Office of the Secretary of Commerce NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited §...

  19. 18 CFR 1317.300 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 2 2012-04-01 2012-04-01 false Admission. 1317.300 Section 1317.300 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission...

  20. 38 CFR 17.365 - Admission priorities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Admission priorities. 17.365 Section 17.365 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants to the Republic of the Philippines § 17.365 Admission priorities. Appropriate provisions of §...

  1. 45 CFR 86.21 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex... of sex, be denied admission, or be subjected to discrimination in admission, by any recipient...

  2. 49 CFR 25.300 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Office of the Secretary of Transportation NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 25.300 Admission. (a) General. No person shall, on the basis of sex, be...

  3. 14 CFR 1253.300 - Admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex... basis of sex, be denied admission, or be subjected to discrimination in admission, by any recipient...

  4. 28 CFR 54.300 - Admission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Administration DEPARTMENT OF JUSTICE (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 54.300 Admission. (a) General. No person shall, on the basis of sex, be...

  5. 28 CFR 54.300 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Administration DEPARTMENT OF JUSTICE (CONTINUED) NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 54.300 Admission. (a) General. No person shall, on the basis of sex, be...

  6. Admissions and Preferences: Sequel to Defunis

    ERIC Educational Resources Information Center

    Wilson, James B.

    1973-01-01

    Three unresolved affirmative action admissions problems are examined: the role of students in admissions decisions, the validity of racial quotas, and to what extent applicants are entitled to due process protection of the fourteenth ammendment. Included is a synopsis of DeFunis v. Odegaard, which upheld a reverse discrimination claim. (JT)

  7. Lexical Profiles of Thailand University Admission Tests

    ERIC Educational Resources Information Center

    Cherngchawano, Wirun; Jaturapitakkul, Natjiree

    2014-01-01

    University Admission Tests in Thailand are important documents which reflect Thailand's education system. To study at a higher education level, all students generally need to take the University Admission Tests designed by the National Institute of Educational Testing Service (NIETS). For the English test, vocabulary and reading comprehension is…

  8. 7 CFR 503.2 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Admission. 503.2 Section 503.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.2 Admission. No person will be admitted to PIADC,...

  9. 7 CFR 503.2 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Admission. 503.2 Section 503.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.2 Admission. No person will be admitted to PIADC,...

  10. 7 CFR 503.2 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Admission. 503.2 Section 503.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.2 Admission. No person will be admitted to PIADC,...

  11. 7 CFR 503.2 - Admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Admission. 503.2 Section 503.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.2 Admission. No person will be admitted to PIADC,...

  12. 7 CFR 503.2 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Admission. 503.2 Section 503.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON PLUM ISLAND ANIMAL DISEASE CENTER § 503.2 Admission. No person will be admitted to PIADC,...

  13. 38 CFR 17.365 - Admission priorities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2014-07-01 2014-07-01 false Admission priorities. 17.365 Section 17.365 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants to the Republic of the Philippines § 17.365 Admission priorities. Appropriate provisions of §...

  14. 38 CFR 17.365 - Admission priorities.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2012-07-01 2012-07-01 false Admission priorities. 17.365 Section 17.365 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants to the Republic of the Philippines § 17.365 Admission priorities. Appropriate provisions of §...

  15. 38 CFR 17.365 - Admission priorities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2013-07-01 2013-07-01 false Admission priorities. 17.365 Section 17.365 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants to the Republic of the Philippines § 17.365 Admission priorities. Appropriate provisions of §...

  16. 38 CFR 17.365 - Admission priorities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2011-07-01 2011-07-01 false Admission priorities. 17.365 Section 17.365 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS MEDICAL Grants to the Republic of the Philippines § 17.365 Admission priorities. Appropriate provisions of §...

  17. 45 CFR 86.21 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex... of sex, be denied admission, or be subjected to discrimination in admission, by any recipient...

  18. 45 CFR 86.21 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex... of sex, be denied admission, or be subjected to discrimination in admission, by any recipient...

  19. The Terms and Tasks of "Open Admissions"

    ERIC Educational Resources Information Center

    Scott, Robert A.

    1976-01-01

    Noting the need to define the terms used for policies which are changing the role of admissions offices, the author defines "open admissions" as "universal opportunity for post-secondary schooling" and points out changes in the core tasks of recruiting, selecting, counseling, and management of student records and data. (JT)

  20. 14 CFR 1253.220 - Admissions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Admissions. 1253.220 Section 1253.220 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 1253.220 Admissions....

  1. 14 CFR 1253.220 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Admissions. 1253.220 Section 1253.220 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 1253.220 Admissions....

  2. 14 CFR 1253.220 - Admissions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Admissions. 1253.220 Section 1253.220 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 1253.220 Admissions....

  3. 14 CFR 1253.220 - Admissions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Admissions. 1253.220 Section 1253.220 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 1253.220 Admissions....

  4. 14 CFR § 1253.220 - Admissions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Admissions. § 1253.220 Section § 1253.220 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 1253.220 Admissions....

  5. Grade Inflation and Law School Admissions

    ERIC Educational Resources Information Center

    Wongsurawat, Winai

    2008-01-01

    Purpose: The purpose of this paper is to evaluate the evidence on whether grade inflation has led to an increasing emphasis on standardized test scores as a criterion for law school admissions. Design/methodology/approach: Fit probabilistic models to admissions data for American law schools during the mid to late 1990s, a period during which…

  6. Simulated Admissions Exercise in Health Services Administration.

    ERIC Educational Resources Information Center

    Quatrano, Louis A.; And Others

    This workbook is intended for use in a Simulated Admissions Exercise (SAE). Done in group settings, the SAE establishes mock admissions committees which work through simulated student applications to choose a certain number to be "admitted" to a hypothetical class of students. The applicants are seeking positions in a health services…

  7. Understanding the Bologna Process for Admissions Officers

    ERIC Educational Resources Information Center

    Baxton, Mary; Johnson, Johnny Kent; Nathanson, Gloria; Paver, William; Watkins, Robert

    2009-01-01

    In Spring 2008, senior members of the international admission and credential evaluation community met to deliberate over the admission and placement of Bologna Compliant degree holders into U.S. graduate programs. This group comprised several individuals holding top leadership positions in NAFSA, AACRAO, and closely allied groups involved in…

  8. 45 CFR 86.21 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Department of Health and Human Services GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex... of sex, be denied admission, or be subjected to discrimination in admission, by any recipient...

  9. 43 CFR 41.300 - Admission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Lands: Interior Office of the Secretary of the Interior NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex... basis of sex, be denied admission, or be subjected to discrimination in admission, by any recipient...

  10. Profile of poisoning admissions in Malaysia.

    PubMed

    Rajasuriar, R; Awang, R; Hashim, S B H; Rahmat, H R B H

    2007-02-01

    We retrospectively reviewed poisoning admissions to all government health facilities from 1999 to 2001, in an effort to expand our current knowledge on poisoning in Malaysia to a level that better reflects a nationwide burden. There were 21 714 admissions reported with 779 deaths. The case-fatality rate was 35.88/1000 admissions. The majority of admissions (89.7%) and deaths (98.9%) occurred in adults. Some 55.1% of all admissions were female, mostly involving pharmaceutical agents. Male poisoning admissions were more often due to chemical substances. The prevalence of poisoning and death was highest among Indians compared to all other races in Malaysia. Overall, the majority of poisoning admissions were due to pharmaceutical agents, with agents classified as non-opioid analgesics, anti-pyretics and anti-rheumatics the most common. Pesticides accounted for the largest number of fatalities. It was also the commonest substance reported in cases of intentional self-harm. Most cases of poisoning admissions occurred due to accidental exposure (47%), followed by cases of intentional self-harm (20.7%). Overall, this study has managed to contribute substantial additional information regarding the epidemiology of poisoning in Malaysia, highlighting important issues, such as the rampant poisonings involving pesticides and analgesics, as well as the high prevalence of poisoning among Indians in Malaysia.

  11. An Economic Analysis of College Admission Standards.

    ERIC Educational Resources Information Center

    Costrell, Robert M.

    1993-01-01

    The effects of relaxed college admission standards vary across students. A relaxed standard may raise the number of graduates but reduces nongraduates' productivity. The effect on the graduation rate is ambiguous, since "marginal" college attendees are less likely to graduate. A lower admission standard reduces performance among students exceeding…

  12. Profile in Action: Linking Admission and Retention

    ERIC Educational Resources Information Center

    Cortes, Carla M.

    2013-01-01

    A profile-oriented retention strategy embraces the admission process as a powerful lever in improving retention and completion rates and recognizes that the student profile can be shaped by changes in admission policies or priorities--even within the current market position of the institution. In addition, the student body can be oriented toward…

  13. An Admissions Race that's Already Won

    ERIC Educational Resources Information Center

    Stevens, Mitchell L.

    2008-01-01

    The author recently spent a year and a half in the admissions office of a highly selective Eastern college as an ethnographer, seeking to understand just how admissions officers make their decisions. He accompanied them on recruitment trips to high schools and college fairs, helped manage their offices' relentless current of visitors and mail, and…

  14. 44 CFR 68.9 - Admissible evidence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Admissible evidence. 68.9... PROCEDURES § 68.9 Admissible evidence. (a) Legal rules of evidence shall not be in effect at adminstrative hearings. However, only evidence relevant to issues within the scope of review under § 68.8 shall...

  15. Control of cardiac alternans by mechanical and electrical feedback

    NASA Astrophysics Data System (ADS)

    Yapari, Felicia; Deshpande, Dipen; Belhamadia, Youssef; Dubljevic, Stevan

    2014-07-01

    A persistent alternation in the cardiac action potential duration has been linked to the onset of ventricular arrhythmia, which may lead to sudden cardiac death. A coupling between these cardiac alternans and the intracellular calcium dynamics has also been identified in previous studies. In this paper, the system of PDEs describing the small amplitude of alternans and the alternation of peak intracellular Ca2+ are stabilized by optimal boundary and spatially distributed actuation. A simulation study demonstrating the successful annihilation of both alternans on a one-dimensional cable of cardiac cells by utilizing the full-state feedback controller is presented. Complimentary to these studies, a three variable Nash-Panfilov model is used to investigate alternans annihilation via mechanical (or stretch) perturbations. The coupled model includes the active stress which defines the mechanical properties of the tissue and is utilized in the feedback algorithm as an independent input from the pacing based controller realization in alternans annihilation. Simulation studies of both control methods demonstrate that the proposed methods can successfully annihilate alternans in cables that are significantly longer than 1 cm, thus overcoming the limitations of earlier control efforts.

  16. Controller modeling and evaluation for PCV electro-mechanical actuator

    NASA Astrophysics Data System (ADS)

    Parker, Joey K.

    1993-11-01

    Hydraulic actuators are currently used to operate the propellant control valves (PCV) for the space shuttle main engine (SSME) and other rocket engines. These actuators are characterized by large power to weight ratios, large force capabilities, and rapid accelerations, which favor their use in control valve applications. However, hydraulic systems are also characterized by susceptibility to contamination, which leads to frequent maintenance requirements. The Control Mechanisms Branch (EP34) of the Component Development Division of the Propulsion Laboratory at the Marshall Space Flight Center (MSFC) has been investigating the application of electromechanical actuators as replacements for the hydraulic units in PCV's over the last few years. This report deals with some testing and analysis of a PCV electromechanical actuator (EMA) designed and fabricated by HR Textron, Inc. This prototype actuator has undergone extensive testing by EP34 personnel since early 1993. At this time, the performance of the HR Textron PCV EMA does not meet requirements for position tracking.

  17. Controller modeling and evaluation for PCV electro-mechanical actuator

    NASA Technical Reports Server (NTRS)

    Parker, Joey K.

    1993-01-01

    Hydraulic actuators are currently used to operate the propellant control valves (PCV) for the space shuttle main engine (SSME) and other rocket engines. These actuators are characterized by large power to weight ratios, large force capabilities, and rapid accelerations, which favor their use in control valve applications. However, hydraulic systems are also characterized by susceptibility to contamination, which leads to frequent maintenance requirements. The Control Mechanisms Branch (EP34) of the Component Development Division of the Propulsion Laboratory at the Marshall Space Flight Center (MSFC) has been investigating the application of electromechanical actuators as replacements for the hydraulic units in PCV's over the last few years. This report deals with some testing and analysis of a PCV electromechanical actuator (EMA) designed and fabricated by HR Textron, Inc. This prototype actuator has undergone extensive testing by EP34 personnel since early 1993. At this time, the performance of the HR Textron PCV EMA does not meet requirements for position tracking.

  18. Bilingualism modulates dual mechanisms of cognitive control: Evidence from ERPs.

    PubMed

    Morales, Julia; Yudes, Carolina; Gómez-Ariza, Carlos J; Bajo, M Teresa

    2015-01-01

    Recent behavioral findings with the AX-Continous Performance Task (AX-CPT; Morales et al., 2013) show that bilinguals only outperform monolinguals under conditions that require the highest adjustment between monitoring (proactive) and inhibitory (reactive) control, which supports the idea that bilingualism modulates the coordination of different control mechanisms. In an ERP experiment we aimed to further investigate the role that bilingualism plays in the dynamic combination of proactive and reactive control in the AX-CPT. Our results strongly indicate that bilingualism facilitates an effective adjustment between both components of cognitive control. First, we replicated previous behavioral results. Second, ERP components indicated that bilingualism influences the conflict monitoring, response inhibition and error monitoring components of control (as indexed by the N2 and P3a elicited by the probe and the error-related negativity following incorrect responses, respectively). Thus, bilinguals exerted higher reactive control than monolinguals but only when they needed to overcome the competing cue-information. These findings join others in suggesting that a better understanding of the cognitive benefits of bilingualism may require consideration of a multi-component perspective. PMID:25448864

  19. Flexible neural mechanisms of cognitive control within human prefrontal cortex.

    PubMed

    Braver, Todd S; Paxton, Jessica L; Locke, Hannah S; Barch, Deanna M

    2009-05-01

    A major challenge in research on executive control is to reveal its functional decomposition into underlying neural mechanisms. A typical assumption is that this decomposition occurs solely through anatomically based dissociations. Here we tested an alternative hypothesis that different cognitive control processes may be implemented within the same brain regions, with fractionation and dissociation occurring on the basis of temporal dynamics. Regions within lateral prefrontal cortex (PFC) were examined that, in a prior study, exhibited contrasting temporal dynamics between older and younger adults during performance of the AX-CPT cognitive control task. The temporal dynamics in younger adults fit a proactive control pattern (primarily cue-based activation), whereas in older adults a reactive control pattern was found (primarily probe-based activation). In the current study, we found that following a period of task-strategy training, these older adults exhibited a proactive shift within a subset of the PFC regions, normalizing their activity dynamics toward young adult patterns. Conversely, under conditions of penalty-based monetary incentives, the younger adults exhibited a reactive shift some of the same regions, altering their temporal dynamics toward the older adult baseline pattern. These experimentally induced crossover patterns of temporal dynamics provide strong support for dual modes of cognitive control that can be flexibly shifted within PFC regions, via modulation of neural responses to changing task conditions or behavioral goals. PMID:19380750

  20. Bilingualism modulates dual mechanisms of cognitive control: Evidence from ERPs.

    PubMed

    Morales, Julia; Yudes, Carolina; Gómez-Ariza, Carlos J; Bajo, M Teresa

    2015-01-01

    Recent behavioral findings with the AX-Continous Performance Task (AX-CPT; Morales et al., 2013) show that bilinguals only outperform monolinguals under conditions that require the highest adjustment between monitoring (proactive) and inhibitory (reactive) control, which supports the idea that bilingualism modulates the coordination of different control mechanisms. In an ERP experiment we aimed to further investigate the role that bilingualism plays in the dynamic combination of proactive and reactive control in the AX-CPT. Our results strongly indicate that bilingualism facilitates an effective adjustment between both components of cognitive control. First, we replicated previous behavioral results. Second, ERP components indicated that bilingualism influences the conflict monitoring, response inhibition and error monitoring components of control (as indexed by the N2 and P3a elicited by the probe and the error-related negativity following incorrect responses, respectively). Thus, bilinguals exerted higher reactive control than monolinguals but only when they needed to overcome the competing cue-information. These findings join others in suggesting that a better understanding of the cognitive benefits of bilingualism may require consideration of a multi-component perspective.

  1. Mechanical versus manual chest compressions for out-of-hospital cardiac arrest: a meta-analysis of randomized controlled trials.

    PubMed

    Tang, Lu; Gu, Wan-Jie; Wang, Fei

    2015-01-01

    Recent evidence regarding mechanical chest compressions in out-of-hospital cardiac arrest (OHCA) is conflicting. The objective of this study was to perform a meta-analysis of randomized controlled trials (RCTs) to compare the effect of mechanical versus manual chest compressions on resuscitation outcomes in OHCA. PubMed, Embase, the Cochrane Central Register of Controlled Trials, and the ClinicalTrials.gov registry were searched. In total, five RCTs with 12,510 participants were included. Compared with manual chest compressions, mechanical chest compressions did not significantly improve survival with good neurological outcome to hospital discharge (relative risks (RR) 0.80, 95% CI 0.61-1.04, P = 0.10; I(2) = 65%), return of spontaneous circulation (RR 1.02, 95% CI 0.95-1.09, P = 0.59; I(2) = 0%), or long-term (≥6 months) survival (RR 0.96, 95% CI 0.79-1.16, P = 0.65; I(2) = 16%). In addition, mechanical chest compressions were associated with worse survival to hospital admission (RR 0.94, 95% CI 0.89-1.00, P = 0.04; I(2) = 0%) and to hospital discharge (RR 0.88, 95% CI 0.78-0.99, P = 0.03; I(2) = 0%). Based on the current evidence, widespread use of mechanical devices for chest compressions in OHCA cannot be recommended. PMID:26503429

  2. Atmospheric pollutants and hospital admissions due to pneumonia in children

    PubMed Central

    Negrisoli, Juliana; Nascimento, Luiz Fernando C.

    2013-01-01

    OBJECTIVE: To analyze the relationship between exposure to air pollutants and hospitalizations due to pneumonia in children of Sorocaba, São Paulo, Brazil. METHODS: Time series ecological study, from 2007 to 2008. Daily data were obtained from the State Environmental Agency for Pollution Control for particulate matter, nitric oxide, nitrogen dioxide, ozone, besides air temperature and relative humidity. The data concerning pneumonia admissions were collected in the public health system of Sorocaba. Correlations between the variables of interest using Pearson cofficient were calculated. Models with lags from zero to five days after exposure to pollutants were performed to analyze the association between the exposure to environmental pollutants and hospital admissions. The analysis used the generalized linear model of Poisson regression, being significant p<0.05. RESULTS: There were 1,825 admissions for pneumonia, with a daily mean of 2.5±2.1. There was a strong correlation between pollutants and hospital admissions, except for ozone. Regarding the Poisson regression analysis with the multi-pollutant model, only nitrogen dioxide was statistically significant in the same day (relative risk - RR=1.016), as well as particulate matter with a lag of four days (RR=1.009) after exposure to pollutants. CONCLUSIONS: There was an acute effect of exposure to nitrogen dioxide and a later effect of exposure to particulate matter on children hospitalizations for pneumonia in Sorocaba. PMID:24473956

  3. Mechanical control of mitotic progression in single animal cells.

    PubMed

    Cattin, Cedric J; Düggelin, Marcel; Martinez-Martin, David; Gerber, Christoph; Müller, Daniel J; Stewart, Martin P

    2015-09-01

    Despite the importance of mitotic cell rounding in tissue development and cell proliferation, there remains a paucity of approaches to investigate the mechanical robustness of cell rounding. Here we introduce ion beam-sculpted microcantilevers that enable precise force-feedback-controlled confinement of single cells while characterizing their progression through mitosis. We identify three force regimes according to the cell response: small forces (∼5 nN) that accelerate mitotic progression, intermediate forces where cells resist confinement (50-100 nN), and yield forces (>100 nN) where a significant decline in cell height impinges on microtubule spindle function, thereby inhibiting mitotic progression. Yield forces are coincident with a nonlinear drop in cell height potentiated by persistent blebbing and loss of cortical F-actin homogeneity. Our results suggest that a buildup of actomyosin-dependent cortical tension and intracellular pressure precedes mechanical failure, or herniation, of the cell cortex at the yield force. Thus, we reveal how the mechanical properties of mitotic cells and their response to external forces are linked to mitotic progression under conditions of mechanical confinement.

  4. A ratchet mechanism of transcription elongation and its control.

    PubMed

    Bar-Nahum, Gil; Epshtein, Vitaly; Ruckenstein, Andrei E; Rafikov, Ruslan; Mustaev, Arkady; Nudler, Evgeny

    2005-01-28

    RNA chain elongation is a highly processive and accurate process that is finely regulated by numerous intrinsic and extrinsic signals. Here we describe a general mechanism that governs RNA polymerase (RNAP) movement and response to regulatory inputs such as pauses, terminators, and elongation factors. We show that E.coli RNAP moves by a complex Brownian ratchet mechanism, which acts prior to phosphodiester bond formation. The incoming substrate and the flexible F bridge domain of the catalytic center serve as two separate ratchet devices that function in concert to drive forward translocation. The adjacent G loop domain controls F bridge motion, thus keeping the proper balance between productive and inactive states of the elongation complex. This balance is critical for cell viability since it determines the rate, processivity, and fidelity of transcription.

  5. Cellular and molecular mechanisms controlling the migration of neocortical interneurons.

    PubMed

    Marín, Oscar

    2013-07-01

    The discovery, approximately 15 years ago, that cortical GABAergic interneurons originate outside the pallium has revolutionized our understanding of the development of the cerebral cortex. It is now clear that glutamatergic pyramidal cells and GABAergic interneurons follow largely distinct development programs, a notion that has challenged our views on how these neurons assemble to form precise neural circuits. In this review, I summarize our current knowledge of the mechanisms that control the migration of neocortical interneurons, a process that can be subdivided into three consecutive phases: migration to the cortex, intracortical dispersion, and layering.

  6. Re-Admissions Following Hip Fracture Surgery

    PubMed Central

    Hahnel, James; Burdekin, Hannah; Anand, Sanjeev

    2009-01-01

    INTRODUCTION Hip fractures in the elderly are a growing problem with a predicted incidence of 117,000 cases per year by 2016. Re-admission following a healthcare episode is an important outcome measure, which reflects non-fatal adverse events and indicates the natural history of disease. The purpose of this observational, multicentre audit was to examine rates and reasons for re-admission following hip fracture, to identify areas in the index admission and rehabilitation care that could be improved to prevent re-admission. PATIENTS AND METHODS A total of 535 patients (> 65 years old) in two district general hospitals in the UK who underwent hip fracture surgery were recruited into the study. RESULTS Of the study cohort, 72 patients (13.5%) died during their index admission and 88 (19.0%) of 463 patients were re-admitted once within 3 months. Causes of re-admission were attributed to medical (54.8%), failure to rehabilitate (23.8%), orthopaedic (19.0%) and surgical (2.4%) reasons. Infection was the most common (31.0%) reason for re-admission and arguably the most treatable. During the 3-month postoperative period, the mortality rate was 21.3%, increasing in those re-admitted to 35.1% representing the frailty of this group of patients. CONCLUSIONS High rates of re-admission are seen following discharge in elderly patients with hip fractures. Re-admitted patients have high mortality rates. Understanding causes of re-admission may help to reduce this burden. PMID:19558764

  7. Heralded Control of Mechanical Motion by Single Spins.

    PubMed

    Rao, D D Bhaktavatsala; Momenzadeh, S Ali; Wrachtrup, Jörg

    2016-08-12

    We propose a method to achieve a high degree of control of nanomechanical oscillators by coupling their mechanical motion to single spins. Manipulating the spin alone and measuring its quantum state heralds the cooling or squeezing of the oscillator even for weak spin-oscillator couplings. We analytically show that the asymptotic behavior of the oscillator is determined by a spin-induced thermal filter function whose overlap with the initial thermal distribution of the oscillator determines its cooling, heating, or squeezing. Counterintuitively, the rate of cooling dependence on the instantaneous thermal occupancy of the oscillator renders robust cooling or squeezing even for high initial temperatures and damping rates. We further estimate how the proposed scheme can be used to control the motion of a thin diamond cantilever by coupling it to its defect centers at low temperature. PMID:27563995

  8. Heralded Control of Mechanical Motion by Single Spins

    NASA Astrophysics Data System (ADS)

    Rao, D. D. Bhaktavatsala; Momenzadeh, S. Ali; Wrachtrup, Jörg

    2016-08-01

    We propose a method to achieve a high degree of control of nanomechanical oscillators by coupling their mechanical motion to single spins. Manipulating the spin alone and measuring its quantum state heralds the cooling or squeezing of the oscillator even for weak spin-oscillator couplings. We analytically show that the asymptotic behavior of the oscillator is determined by a spin-induced thermal filter function whose overlap with the initial thermal distribution of the oscillator determines its cooling, heating, or squeezing. Counterintuitively, the rate of cooling dependence on the instantaneous thermal occupancy of the oscillator renders robust cooling or squeezing even for high initial temperatures and damping rates. We further estimate how the proposed scheme can be used to control the motion of a thin diamond cantilever by coupling it to its defect centers at low temperature.

  9. Control of mechanical systems with rolling constraints: Application to dynamic control of mobile robots

    NASA Technical Reports Server (NTRS)

    Sarkar, Nilanjan; Yun, Xiaoping; Kumar, Vijay

    1994-01-01

    There are many examples of mechanical systems that require rolling contacts between two or more rigid bodies. Rolling contacts engender nonholonomic constraints in an otherwise holonomic system. In this article, we develop a unified approach to the control of mechanical systems subject to both holonomic and nonholonomic constraints. We first present a state space realization of a constrained system. We then discuss the input-output linearization and zero dynamics of the system. This approach is applied to the dynamic control of mobile robots. Two types of control algorithms for mobile robots are investigated: trajectory tracking and path following. In each case, a smooth nonlinear feedback is obtained to achieve asymptotic input-output stability and Lagrange stability of the overall system. Simulation results are presented to demonstrate the effectiveness of the control algorithms and to compare the performane of trajectory-tracking and path-following algorithms.

  10. Weather, season, and daily stroke admissions in Hong Kong

    NASA Astrophysics Data System (ADS)

    Goggins, William B.; Woo, Jean; Ho, Suzanne; Chan, Emily Y. Y.; Chau, P. H.

    2012-09-01

    Previous studies examining daily temperature and stroke incidence have given conflicting results. We undertook this retrospective study of all stroke admissions in those aged 35 years old and above to Hong Kong public hospitals from 1999 through 2006 in order to better understand the effects of meteorological conditions on stroke risk in a subtropical setting. We used Poisson Generalized Additive Models with daily hemorrhagic (HS) and ischemic stroke (IS) counts separately as outcomes, and daily mean temperature, humidity, solar radiation, rainfall, air pressure, pollutants, flu consultation rates, day of week, holidays, time trend and seasonality as predictors. Lagged effects of temperature, humidity and pollutants were also considered. A total of 23,457 HS and 107,505 IS admissions were analyzed. Mean daily temperature had a strong, consistent, negative linear association with HS admissions over the range (8.2-31.8°C) observed. A 1°C lower average temperature over the same day and previous 4 days (lags 0-4) being associated with a 2.7% (95% CI: 2.0-3.4%, P < .0.0001) higher admission rate after controlling for other variables. This association was stronger among older subjects and females. Higher lag 0-4 average change in air pressure from previous day was modestly associated with higher HS risk. The association between IS and temperature was weaker and apparent only below 22°C, with a 1°C lower average temperature (lags 0-13) below this threshold being associated with a 1.6% (95% CI:1.0-2.2%, P < 0.0001) higher IS admission rate. Pollutant levels were not associated with HS or IS. Future studies should examine HS and IS risk separately.

  11. Drug related hospital admissions in subspecialities of internal medicine.

    PubMed

    Hallas, J

    1996-04-01

    probably had a specific effect on avoidable DRHs. Admissions caused by adverse ractions to over-the-counter remedies, usually salicylates, were characterised by a particularly inappropriate use of drugs, suggesting that the public may also be a suitable target for interventions. In 1990 the author established the Odense PharmacoEpidemiologic Database (OPED), a research registry with person-identifiable data on computerised refund claims from Funen County. The registry was validated by a cohort study on the association of non-steroidal antiinflammatory drugs (NSAID) and admission for severe upper gastrointestinal bleeding (UGB). All 31,503 recorded NSAID users in Odense during a 19 month period and a control cohort were studied. For both cohorts we obtained data on admissions caused by UGB and other diagnosis- and prescription-data that would be relevant for confounder control. The standardised incidence ratio was 5.5, controlled for age, sex and previous peptic ulcer episodes. A multivariate analyse revealed a number of other risk factors, but no other important confounders. The standardised incidence of UGB was particularly high during the first month of NSAID therapy. The size of the data set permitted an estimate of excess risk within various patient categories. NSAID users over 75 years of age or with a previous peptic ulcer episode had particularly high excess risks. The utilization pattern of NSAIDs was surprisingly sporadic and appeared to favour a high UGB rate for a given sales volume. It is pointed out that individualised dispensing data may be an important tool in future endeavors to control DRH incidences. The data may be used for generating or confirming hypotheses on unknown and suspected ADRs, for studies on risk factors of ADRs, for characterising the population's drug utilization, for identifying objects for interventions and for monitoring the effect of interventions. PMID:8741207

  12. Mechanisms of spatial attention control in frontal and parietal cortex.

    PubMed

    Szczepanski, Sara M; Konen, Christina S; Kastner, Sabine

    2010-01-01

    Theories of spatial attentional control have been largely based upon studies of patients suffering from visuospatial neglect, resulting from circumscribed lesions of frontal and posterior parietal cortex. In the intact brain, the control of spatial attention has been related to a distributed frontoparietal attention network. Little is known about the nature of the control mechanisms exerted by this network. Here, we used a novel region-of-interest approach to relate activations of the attention network to recently described topographic areas in frontal cortex [frontal eye field (FEF), PreCC/IFS (precentral cortex/inferior frontal sulcus)] and parietal cortex [intraparietal sulcus areas (IPS1-IPS5) and an area in the superior parietal lobule (SPL1)] to examine their spatial attention signals. We found that attention signals in most topographic areas were spatially specific, with stronger responses when attention was directed to the contralateral than to the ipsilateral visual field. Importantly, two hemispheric asymmetries were found. First, a region in only right, but not left SPL1 carried spatial attention signals. Second, left FEF and left posterior parietal cortex (IPS1/2) generated stronger contralateral biasing signals than their counterparts in the right hemisphere. These findings are the first to characterize spatial attention signals in topographic frontal and parietal cortex and provide a neural basis in support of an interhemispheric competition account of spatial attentional control. PMID:20053897

  13. Thermal and mechanical controls on magma supply and volcanic deformation

    NASA Astrophysics Data System (ADS)

    Hickey, James; Gottsmann, Jo; Nakamichi, Haruhisa; Iguchi, Masato

    2016-04-01

    Ground deformation often precedes volcanic eruptions, and results from complex interactions between source processes and the thermomechanical behaviour of surrounding rock. Geodetic models aimed at constraining source processes consequently require the implementation of realistic mechanical and thermal rock properties. However, most generic models ignore this requirement and employ oversimplified mechanical assumptions without regard for thermal effects. Here we show how spatio-temporal deformation and magma reservoir evolution are fundamentally controlled by three-dimensional thermomechanical heterogeneity. Using the example of continued inflation at Aira caldera, Japan, we demonstrate that despite on-going eruptions magma is accumulating faster than it can be ejected, and the current uplift is approaching the level inferred prior to the 1914 Plinian eruption. Our results from inverse and forward numerical models are consistent with petrological constraints and highlight how the location, volume, and rate of magma supply, 0.014 km3/yr, are thermomechanically controlled. Magma storage conditions coincide with estimates for the caldera-forming reservoir ˜29,000 years ago, and the inferred magma supply rate indicates a ˜130-year timeframe to amass enough magma to feed a future 1914-sized eruption. These new inferences are important for eruption forecasting and risk mitigation, and have significant implications for the interpretations of volcanic deformation worldwide.

  14. Basic mechanisms controlling the sweeping efficiency of propagating current sheets

    NASA Astrophysics Data System (ADS)

    Berkery, J. W.; Choueiri, E. Y.

    2006-02-01

    The basic mechanisms controlling the sweeping efficiency of propagating current sheets are investigated through experiments and analytical modelling. The sweeping efficiency of a current sheet in a parallel plate gas-fed pulsed plasma accelerator is defined as the ratio of the current sheet mass to the total available propellant mass. Permeability of neutrals through the sheet, and leakage of mass out of the sheet and into a cathode wake, decrease the sweeping efficiency. The sweeping efficiency of current sheets in argon, neon, helium and hydrogen propellants at different initial pressures was determined through measurements of sheet velocity with high speed photography and of sheet mass with laser interferometry. The mechanism that controls the sweeping efficiency of propagating current sheets was found to be an interplay of two processes: the flux of mass entering the sheet and the leakage of mass at the cathode, with the former dependent on the degree of permeability and the latter dependent on the level of ion current as determined by the ion Hall parameter.

  15. Mechanisms and Evolution of Control Logic in Prokaryotic Transcriptional Regulation

    PubMed Central

    van Hijum, Sacha A. F. T.; Medema, Marnix H.; Kuipers, Oscar P.

    2009-01-01

    Summary: A major part of organismal complexity and versatility of prokaryotes resides in their ability to fine-tune gene expression to adequately respond to internal and external stimuli. Evolution has been very innovative in creating intricate mechanisms by which different regulatory signals operate and interact at promoters to drive gene expression. The regulation of target gene expression by transcription factors (TFs) is governed by control logic brought about by the interaction of regulators with TF binding sites (TFBSs) in cis-regulatory regions. A factor that in large part determines the strength of the response of a target to a given TF is motif stringency, the extent to which the TFBS fits the optimal TFBS sequence for a given TF. Advances in high-throughput technologies and computational genomics allow reconstruction of transcriptional regulatory networks in silico. To optimize the prediction of transcriptional regulatory networks, i.e., to separate direct regulation from indirect regulation, a thorough understanding of the control logic underlying the regulation of gene expression is required. This review summarizes the state of the art of the elements that determine the functionality of TFBSs by focusing on the molecular biological mechanisms and evolutionary origins of cis-regulatory regions. PMID:19721087

  16. Multi-function magnetic jack control drive mechanism

    DOEpatents

    Bollinger, L.R.; Crawford, D.C.

    1983-10-06

    A multi-function magnetic jack control drive mechanism for controlling a nuclear reactor is provided. The mechanism includes an elongate pressure housing in which a plurality of closely spaced drive rods are located. Each drive rod is connected to a rod which is insertable in the reactor core. An electromechanical stationary latch device is provided which is actuatable to hold each drive rod stationary with respect to the pressure housing. An electromechanical movable latch device is also provided for each one of the drive rods. Each movable latch device is provided with a base and is actuatable to hold a respective drive rod stationary with respect to the base. An electromechanical lift device is further provided for each base which is actuatable for moving a respective base longitudinally along the pressure housing. In this manner, one or more drive rods can be moved in the pressure housing by sequentially and repetitively operating the electromechanical devices. Preferably, each latch device includes a pair of opposed latches which grip teeth located on the respective drive rod. Two, three, or four drive rods can be located symmetrically about the longitudinal axis of the pressure housing.

  17. Multi-function magnetic jack control drive mechanism

    DOEpatents

    Bollinger, Lawrence R.; Crawford, Donald C.

    1986-01-01

    A multi-function magnetic jack control drive mechanism for controlling a nuclear reactor is provided. The mechanism includes an elongate pressure housing in which a plurality of closely spaced drive rods are located. Each drive rod is connected to a rod which is insertable in the reactor core. An electromechanical stationary latch device is provided which is actuatable to hold each drive rod stationary with respect to the pressure housing. An electromechanical movable latch device is also provided for each one of the drive rods. Each movable latch device is provided with a base and is actuatable to hold a respective drive rod stationary with respect to the base. An electromechanical lift device is further provided for each base which is actuatable for moving a respective base longitudinally along the pressure housing. In this manner, one or more drive rods can be moved in the pressure housing by sequentially and repetitively operating the electromechanical devices. Preferably, each latch device includes a pair of opposed latches which grip teeth located on the respective drive rod. Two, three, or four drive rods can be located symmetrically about the longitudinal axis of the pressure housing.

  18. Auction Mechanism to Allocate Air Traffic Control Slots

    NASA Technical Reports Server (NTRS)

    Raffarin, Marianne

    2003-01-01

    This article deals with an auction mechanism for airspace slots, as a means of solving the European airspace congestion problem. A disequilibrium, between Air Traffic Control (ATC) services supply and ATC services demand are at the origin of almost one fourth of delays in the air transport industry in Europe. In order to tackle this congestion problem, we suggest modifying both pricing and allocation of ATC services, by setting up an auction mechanism. Objects of the auction will be the right for airlines to cross a part of the airspace, and then to benefit from ATC services over a period corresponding to the necessary time for the crossing. Allocation and payment rules have to be defined according to the objectives of this auction. The auctioneer is the public authority in charge of ATC services, whose aim is to obtain an efficient allocation. Therefore, the social value will be maximized. Another objective is to internalize congestion costs. To that end, we apply the principle of Clarke-Groves mechanism auction: each winner has to pay the externalities imposed on other bidders. The complex context of ATC leads to a specific design for this auction.

  19. Emergent patterns of growth controlled by multicellular form and mechanics

    PubMed Central

    Nelson, Celeste M.; Jean, Ronald P.; Tan, John L.; Liu, Wendy F.; Sniadecki, Nathan J.; Spector, Alexander A.; Chen, Christopher S.

    2005-01-01

    Spatial patterns of cellular growth generate mechanical stresses that help to push, fold, expand, and deform tissues into their specific forms. Genetic factors are thought to specify patterns of growth and other behaviors to drive morphogenesis. Here, we show that tissue form itself can feed back to regulate patterns of proliferation. Using microfabrication to control the organization of sheets of cells, we demonstrated the emergence of stable patterns of proliferative foci. Regions of concentrated growth corresponded to regions of high tractional stress generated within the sheet, as predicted by a finite-element model of multicellular mechanics and measured directly by using a micromechanical force sensor array. Inhibiting actomyosin-based tension or cadherin-mediated connections between cells disrupted the spatial pattern of proliferation. These findings demonstrate the existence of patterns of mechanical forces that originate from the contraction of cells, emerge from their multicellular organization, and result in patterns of growth. Thus, tissue form is not only a consequence but also an active regulator of tissue growth. PMID:16049098

  20. Eye mechanics and their implications for eye movement control

    NASA Astrophysics Data System (ADS)

    Koene, Ansgar Roald

    2002-11-01

    The topic of this thesis is the investigation of the mechanical properties of the oculomotor system and the implications of these properties for eye movement control. The investigation was conducted by means of computer models and simulations. This allowed us to combine data from anatomy, physiology and psychophysics with basic principles of physics (mechanics) and mathematics (geometry). In chapter 2 we investigate the degree to which mechanical and neural non-linearities contribute to the kinematic differences between centrifugal and centripetal saccades. On the basis of the velocity profiles of centrifugal and centripetal saccades we calculate the forces and muscle innervations during these eye movements. This was done using an inverted model of the eye plant. Our results indicate that the non-linear force-velocity relationship (i.e. muscle viscosity) of the muscles is probably the cause of the kinematic differences between centrifugal and centripetal saccades. In chapter 3 we calculate the adjustment of the saccadic command that is necessary to compensate for the eye plant non-linearities. These calculations show that the agonist and antagonist muscles require different net saccade signal gain changes. In order to better understand how this gain change is accomplished we use the inverted model of the eye plant (chapter 2) to calculate the muscle innervation profiles of saccades with different starting orientations. Based on these calculations we conclude that the saccade signal gain changes are accomplished primarily by changes in the magnitude of the saccade signal. In chapter 4 we examine the requirements that the oculomotor system must meet for the eye to be able to make desired gaze changes and fixate at various eye orientations. We first determine how the axes of action (i.e. unit moment vectors) of the muscles are related to eye orientation and the location of the effective muscle origin (i.e. the muscle pulleys). Next we show how this relation constrains

  1. Stochastic retinal mechanisms of light adaptation and gain control.

    PubMed

    Rudd, M E; Brown, L G

    1996-01-01

    Under appropriate experimental conditions, the threshold intensity of a visual stimulus varies as the square-root of the background illuminance. This square-root law has been observed in both psychophysical threshold experiments and in measurements of the thresholds of individual ganglion cells. A signal detection theory developed in the 1940s by H. L. de Vries and A. Rose, and since elaborated by H. B. Barlow and others, explains the square-root law on the basis of 'noise' due to fluctuations in the number of photon absorptions per unit area and unit time at the cornea. An alternative account of the square-root law--and also other threshold-vs-intensity slopes--is founded on the assumption of physiological gain control (W. A. H. Rushton, Proc, Roy. Soc. (London) B 162, 20-46, 1965; W. S. Geisler, J. Physiol. (London) 312, 165-179, 1979). In this paper, a neural model of light adaptation and gain control is described that shows how these two accounts of the square-root law can be reconciled by a stochastic gain control mechanism whose gain depends on the photon fluctuation level. The process by which spikes are generated in a ganglion cell is modeled in terms of a stochastic integrate-and-fire mechanism; this model is used to quantitatively fit toad retinal ganglion cell threshold data. A psychophysical model is then outlined showing how a statistical observer could analyze the ganglion cell spike trains generated by 'signal' and 'noise' trials in order to statistically discriminate the two conditions. The model is also shown to account for some dynamic aspects of ganglion cell responses, including ON- and OFF-responses. The neural light adaptation model predicts that--under the proper conditions--brightness matching judgments will also be subject to a square-root law. Experimental tests of the model under superthreshold conditions are proposed.

  2. Marketing in Admissions: The Information System Approach.

    ERIC Educational Resources Information Center

    Wofford, O. Douglas; Timmerman, Ed

    1982-01-01

    A marketing information system approach for college admissions is outlined that includes objectives, information needs and sources, a data collection format, and information evaluation. Coordination with other institutional information systems is recommended. (MSE)

  3. The Impact of Bakke on Admissions Programs.

    ERIC Educational Resources Information Center

    Simmons, Ron; Macklin, Dave

    1980-01-01

    The Bakke decision will cause institutions to strengthen academic support programs, improve admissions procedures, and develop stronger evaluation programs. Institutions will see more "reverse discrimination" cases in the future. (Author)

  4. School holidays and admissions with asthma.

    PubMed

    Storr, J; Lenney, W

    1989-01-01

    The admission rate for asthma at a children's hospital was studied over an 11 year period. Admissions varied unpredictably over periods of a few days, but there was a repeated yearly pattern of peaks and troughs with an interval of several weeks. The short term variation could be attributed to chance effects alone, excluding any important role for short term influences--for example, weather changes--in precipitating asthma admissions. There was a definite association between the longer term variation and school holidays. The admission rate fell during holidays and there were two or more peaks during terms. The pattern is consistent with a largely viral aetiology for asthmatic attacks throughout the year. We postulate that school holidays disrupt the spread of viral infections in a community, with synchronisation of subsequent attacks. Travel during holidays may facilitate acquisition of new viral strains by the community.

  5. School holidays and admissions with asthma.

    PubMed Central

    Storr, J; Lenney, W

    1989-01-01

    The admission rate for asthma at a children's hospital was studied over an 11 year period. Admissions varied unpredictably over periods of a few days, but there was a repeated yearly pattern of peaks and troughs with an interval of several weeks. The short term variation could be attributed to chance effects alone, excluding any important role for short term influences--for example, weather changes--in precipitating asthma admissions. There was a definite association between the longer term variation and school holidays. The admission rate fell during holidays and there were two or more peaks during terms. The pattern is consistent with a largely viral aetiology for asthmatic attacks throughout the year. We postulate that school holidays disrupt the spread of viral infections in a community, with synchronisation of subsequent attacks. Travel during holidays may facilitate acquisition of new viral strains by the community. PMID:2923458

  6. Controlling Micro ElectroMechanical Systems (MEMS) in Space

    NASA Astrophysics Data System (ADS)

    Farrar, D.; Schneider, W.; Osiander, R.; Champion, J. L.; Darrin, A. G.; Douglas, D.; Swanson, T. D.

    2003-01-01

    Small spacecraft, including micro and nanosats, as they are envisioned for future missions, will require an alternative means to achieve thermal control due to their small power and mass budgets. One of the proposed alternatives is Variable Emittance (Vari-E) Coatings for spacecraft radiators. Space Technology-5 (ST-5) is a technology demonstration mission through NASA Goddard Space Flight Center (GSFC) that will utilize Vari-E Coatings. This mission involves a constellation of three (3) satellites in a highly elliptical orbit with a perigee altitude of ~200 km and an apogee of ~38,000 km. Such an environment will expose the spacecraft to a wide swing in the thermal and radiation environment of the earth's atmosphere. There are three (3) different technologies associated with this mission. The three technologies are electrophoretic, electrochromic, and Micro ElectroMechanical Systems (MEMS). The ultimate goal is to make use of Vari-E coatings, in order to achieve various levels of thermal control. The focus of this paper is to highlight the Vari-E Coating MEMS instrument, with an emphasis on the Electronic Control Unit responsible for operating the MEMS device. The Test & Evaluation approach, along with the results, is specific for application on ST-5, yet the information provides a guideline for future experiments and/or thermal applications on the exterior structure of a spacecraft.

  7. Mechanisms of control of neuron survival by the endocannabinoid system.

    PubMed

    Galve-Roperh, Ismael; Aguado, Tania; Palazuelos, Javier; Guzmán, Manuel

    2008-01-01

    Endocannabinoids act as retrograde messengers that, by inhibiting neurotransmitter release via presynaptic CB(1) cannabinoid receptors, regulate the functionality of many synapses. In addition, the endocannabinoid system participates in the control of neuron survival. Thus, CB(1) receptor activation has been shown to protect neurons from acute brain injury as well as in neuroinflammatory conditions and neurodegenerative diseases. Nonetheless, some studies have reported that cannabinoids can also exert neurotoxic actions. Cannabinoid neuroprotective activity relies on the inhibition of glutamatergic neurotransmission and on other various mechanisms, and is supported by the observation that the brain overproduces endocannabinoids upon damage. Coupling of neuronal CB(1) receptors to cell survival routes such as the phosphatidylinositol 3-kinase/Akt and extracellular signal-regulated kinase pathways may contribute to cannabinoid neuroprotective action. These pro-survival signals occur, at least in part, by the cross-talk between CB(1) receptors and growth factor tyrosine kinase receptors. Besides promoting neuroprotection, a role for the endocannabinoid system in the control of neurogenesis from neural progenitors has been put forward. In addition, activation of CB(2) cannabinoid receptors on glial cells may also participate in neuroprotection by limiting the extent of neuroinflammation. Altogether, these findings support that endocannabinoids constitute a new family of lipid mediators that act as instructive signals in the control of neuron survival.

  8. Chemo-mechanical control of neural stem cell differentiation

    NASA Astrophysics Data System (ADS)

    Geishecker, Emily R.

    Cellular processes such as adhesion, proliferation, and differentiation are controlled in part by cell interactions with the microenvironment. Cells can sense and respond to a variety of stimuli, including soluble and insoluble factors (such as proteins and small molecules) and externally applied mechanical stresses. Mechanical properties of the environment, such as substrate stiffness, have also been suggested to play an important role in cell processes. The roles of both biochemical and mechanical signaling in fate modification of stem cells have been explored independently. However, very few studies have been performed to study well-controlled chemo-mechanotransduction. The objective of this work is to design, synthesize, and characterize a chemo-mechanical substrate to encourage neuronal differentiation of C17.2 neural stem cells. In Chapter 2, Polyacrylamide (PA) gels of varying stiffnesses are functionalized with differing amounts of whole collagen to investigate the role of protein concentration in combination with substrate stiffness. As expected, neurons on the softest substrate were more in number and neuronal morphology than those on stiffer substrates. Neurons appeared locally aligned with an expansive network of neurites. Additional experiments would allow for statistical analysis to determine if and how collagen density impacts C17.2 differentiation in combination with substrate stiffness. Due to difficulties associated with whole protein approaches, a similar platform was developed using mixed adhesive peptides, derived from fibronectin and laminin, and is presented in Chapter 3. The matrix elasticity and peptide concentration can be individually modulated to systematically probe the effects of chemo-mechanical signaling on differentiation of C17.2 cells. Polyacrylamide gel stiffness was confirmed using rheological techniques and found to support values published by Yeung et al. [1]. Cellular growth and differentiation were assessed by cell counts

  9. A Nationwide Census of ICU Capacity and Admissions in Mongolia

    PubMed Central

    Mendsaikhan, Naranpurev; Begzjav, Tsolmon; Lundeg, Ganbold; Brunauer, Andreas; Dünser, Martin W.

    2016-01-01

    In Mongolia, a Central Asian lower-middle income country, intensive care medicine is an under-resourced and–developed medical specialty. The burden of critical illness and capacity of intensive care unit (ICU) services in the country is unknown. In this nationwide census, we collected data on adult and pediatric/neonatal ICU capacities and the number of ICU admissions in 2014. All hospitals registered to run an ICU service in Mongolia were surveyed. Data on the availability of an adult and/or pediatric/neonatal ICU service, the number of available ICU beds, the number of available functional mechanical ventilators, the number of patients admitted to the ICU, and the number of patients admitted to the study hospital were collected. In total, 70 ICUs with 349 ICU beds were counted in Mongolia (11.7 ICU beds/100,000 inhabitants; 1.7 ICU beds/100 hospital beds). Of these, 241 (69%) were adult and 108 (31%) pediatric/neonatal ICU beds. Functional mechanical ventilators were available for approximately half of the ICU beds (5.1 mechanical ventilators/100,000 inhabitants). While all provincial hospitals ran a pediatric/neonatal ICU, only dedicated pediatric hospitals in Ulaanbaatar did so. The number of adult and pediatric/neonatal ICU admissions varied between provinces. The number of adult ICU beds and adult ICU admissions per 100,000 inhabitants correlated (r = 0.5; p = 0.02), while the number of pediatric/neonatal ICU beds and pediatric/neonatal ICU admissions per 100,000 inhabitants did not (r = 0.25; p = 0.26). In conclusion, with 11.7 ICU beds per 100,000 inhabitants the ICU capacity in Mongolia is higher than in other low- and lower-middle-income countries. Substantial heterogeneities in the standardized ICU capacity and ICU admissions exist between Mongolian provinces. Functional mechanical ventilators are available for only half of the ICU beds. Pediatric/neonatal ICU beds make up one third of the national ICU capacity and appear to meet or even exceed the

  10. The quality of patient experience of short-stay acute medical admissions: findings of the Adult Inpatient Survey in England.

    PubMed

    Sullivan, Paul; Harris, Mary L; Bell, Derek

    2013-12-01

    Introduction of the specialty of acute medicine and of acute medical units (AMUs) in the UK have been associated with improvements in mortality, length of stay and flow, but there is no literature on the patient experience during the early phase of acute medical admissions. We analysed the Adult Inpatient Survey (AIPS) findings for short-stay unscheduled medical admissions who did not move from their first admission ward (n=3325) and therefore are likely to have been managed entirely in the AMU. We compared these with short-stay emergencies in other specialties (n=3420) and short-stay scheduled admissions (n=10,347). Scheduled admissions reported a better experience for all survey items. Scores for unscheduled admissions were worse in medical patients compared with other specialties for pain control, privacy, involvement, information, and for a number of questions relating to information on discharge. The specialty of acute medicine should work to improve future patient experience.

  11. Development of Ti-Nb-Zr alloys with high elastic admissible strain for temporary orthopedic devices.

    PubMed

    Ozan, Sertan; Lin, Jixing; Li, Yuncang; Ipek, Rasim; Wen, Cuie

    2015-07-01

    A new series of beta Ti-Nb-Zr (TNZ) alloys with considerable plastic deformation ability during compression test, high elastic admissible strain, and excellent cytocompatibility have been developed for removable bone tissue implant applications. TNZ alloys with nominal compositions of Ti-34Nb-25Zr, Ti-30Nb-32Zr, Ti-28Nb-35.4Zr and Ti-24.8Nb-40.7Zr (wt.% hereafter) were fabricated using the cold-crucible levitation technique, and the effects of alloying element content on their microstructures, mechanical properties (tensile strength, yield strength, compressive yield strength, Young's modulus, elastic energy, toughness, and micro-hardness), and cytocompatibilities were investigated and compared. Microstructural examinations revealed that the TNZ alloys consisted of β phase. The alloy samples displayed excellent ductility with no cracking, or fracturing during compression tests. Their tensile strength, Young's modulus, elongation at rupture, and elastic admissible strain were measured in the ranges of 704-839 MPa, 62-65 GPa, 9.9-14.8% and 1.08-1.31%, respectively. The tensile strength, Young's modulus and elongation at rupture of the Ti-34Nb-25Zr alloy were measured as 839 ± 31.8 MPa, 62 ± 3.6 GPa, and 14.8 ± 1.6%, respectively; this alloy exhibited the elastic admissible strain of approximately 1.31%. Cytocompatibility tests indicated that the cell viability ratios (CVR) of the alloys are greater than those of the control group; thus the TNZ alloys possess excellent cytocompatibility. PMID:25818950

  12. Control of a mechanical aeration process via topological sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Abdelwahed, M.; Hassine, M.; Masmoudi, M.

    2009-06-01

    The topological sensitivity analysis method gives the variation of a criterion with respect to the creation of a small hole in the domain. In this paper, we use this method to control the mechanical aeration process in eutrophic lakes. A simplified model based on incompressible Navier-Stokes equations is used, only considering the liquid phase, which is the dominant one. The injected air is taken into account through local boundary conditions for the velocity, on the injector holes. A 3D numerical simulation of the aeration effects is proposed using a mixed finite element method. In order to generate the best motion in the fluid for aeration purposes, the optimization of the injector location is considered. The main idea is to carry out topological sensitivity analysis with respect to the insertion of an injector. Finally, a topological optimization algorithm is proposed and some numerical results, showing the efficiency of our approach, are presented.

  13. Small animal radiation research platform: imaging, mechanics, control and calibration.

    PubMed

    Matinfar, Mohammad; Gray, Owen; Iordachita, Iulian; Kennedy, Chris; Ford, Eric; Wong, John; Taylor, Russell H; Kazanzides, Peter

    2007-01-01

    In cancer research, well characterized small animal models of human cancer, such as transgenic mice, have greatly accelerated the pace of development of cancer treatments. The goal of the Small Animal Radiation Research Platform (SARRP) is to make those same models available for the development and evaluation of novel radiation therapies. In combination with advanced imaging methods, small animal research allows detailed study of biological processes, disease progression, and response to therapy, with the potential to provide a natural bridge to the clinical environment. The SARRP will realistically model human radiation treatment methods in standard animal models. In this paper, we describe the mechanical and control structure of the system. This system requires accurate calibration of the x-ray beam for both imaging and radiation treatment, which is presented in detail in the paper. PMID:18044657

  14. Delta3: design and control of a flexure hinge mechanism

    NASA Astrophysics Data System (ADS)

    Bacher, Jean-Philippe; Bottinelli, Stefano; Breguet, Jean-Marc; Clavel, Reymond

    2001-10-01

    In the fields of micro positioning, micromanipulation and micro machining, the required motion precision is continuously increasing. The demand also increases for high dynamic performances (large bandwidth, high closed loop stiffness.). In many cases an inappropriate mechanical structure prevents to achieve these objectives. For example backlash or friction have to be reduced as much as possible. In this paper, we propose backlash-free and friction-free manipulators using flexure hinges and direct drive actuators. A three degrees of freedom (dof) parallel robot (X, Y, Z) that is a transposition in a flexible structure of the Delta robot kinematics is presented. We focus on the design and control of the robot. A simple dynamic model is proposed and compared with measurements. The system is characterized and we propose solutions to improve performances. These solutions are tested on a linear stage.

  15. Market-based control mechanisms for patient safety.

    PubMed

    Coiera, E; Braithwaite, J

    2009-04-01

    A new model is proposed for enhancing patient safety using market-based control (MBC), inspired by successful approaches to environmental governance. Emissions trading, enshrined in the Kyoto protocol, set a carbon price and created a carbon market--is it possible to set a patient safety price and let the marketplace find ways of reducing clinically adverse events? To "cap and trade," a regulator would need to establish system-wide and organisation-specific targets, based on the cost of adverse events, create a safety market for trading safety credits and then police the market. Organisations are given a clear policy signal to reduce adverse event rates, are told by how much, but are free to find mechanisms best suited to their local needs. The market would inevitably generate novel ways of creating safety credits, and accountability becomes hard to evade when adverse events are explicitly measured and accounted for in an organisation's bottom line.

  16. Line-Tension Controlled Mechanism for Influenza Fusion

    PubMed Central

    Risselada, Herre Jelger; Smirnova, Yuliya G.; Grubmüller, Helmut; Marrink, Siewert Jan; Müller, Marcus

    2012-01-01

    Our molecular simulations reveal that wild-type influenza fusion peptides are able to stabilize a highly fusogenic pre-fusion structure, i.e. a peptide bundle formed by four or more trans-membrane arranged fusion peptides. We rationalize that the lipid rim around such bundle has a non-vanishing rim energy (line-tension), which is essential to (i) stabilize the initial contact point between the fusing bilayers, i.e. the stalk, and (ii) drive its subsequent evolution. Such line-tension controlled fusion event does not proceed along the hypothesized standard stalk-hemifusion pathway. In modeled influenza fusion, single point mutations in the influenza fusion peptide either completely inhibit fusion (mutants G1V and W14A) or, intriguingly, specifically arrest fusion at a hemifusion state (mutant G1S). Our simulations demonstrate that, within a line-tension controlled fusion mechanism, these known point mutations either completely inhibit fusion by impairing the peptide’s ability to stabilize the required peptide bundle (G1V and W14A) or stabilize a persistent bundle that leads to a kinetically trapped hemifusion state (G1S). In addition, our results further suggest that the recently discovered leaky fusion mutant G13A, which is known to facilitate a pronounced leakage of the target membrane prior to lipid mixing, reduces the membrane integrity by forming a ‘super’ bundle. Our simulations offer a new interpretation for a number of experimentally observed features of the fusion reaction mediated by the prototypical fusion protein, influenza hemagglutinin, and might bring new insights into mechanisms of other viral fusion reactions. PMID:22761674

  17. Mitochondria-controlled signaling mechanisms of brain protection in hypoxia.

    PubMed

    Lukyanova, Ludmila D; Kirova, Yulia I

    2015-01-01

    The article is focused on the role of the cell bioenergetic apparatus, mitochondria, involved in development of immediate and delayed molecular mechanisms for adaptation to hypoxic stress in brain cortex. Hypoxia induces reprogramming of respiratory chain function and switching from oxidation of NAD-related substrates (complex I) to succinate oxidation (complex II). Transient, reversible, compensatory activation of respiratory chain complex II is a major mechanism of immediate adaptation to hypoxia necessary for (1) succinate-related energy synthesis in the conditions of oxygen deficiency and formation of urgent resistance in the body; (2) succinate-related stabilization of HIF-1α and initiation of its transcriptional activity related with formation of long-term adaptation; (3) succinate-related activation of the succinate-specific receptor, GPR91. This mechanism participates in at least four critical regulatory functions: (1) sensor function related with changes in kinetic properties of complex I and complex II in response to a gradual decrease in ambient oxygen concentration; this function is designed for selection of the most efficient pathway for energy substrate oxidation in hypoxia; (2) compensatory function focused on formation of immediate adaptive responses to hypoxia and hypoxic resistance of the body; (3) transcriptional function focused on activated synthesis of HIF-1 and the genes providing long-term adaptation to low pO2; (4) receptor function, which reflects participation of mitochondria in the intercellular signaling system via the succinate-dependent receptor, GPR91. In all cases, the desired result is achieved by activation of the succinate-dependent oxidation pathway, which allows considering succinate as a signaling molecule. Patterns of mitochondria-controlled activation of GPR-91- and HIF-1-dependent reaction were considered, and a possibility of their participation in cellular-intercellular-systemic interactions in hypoxia and adaptation was

  18. Mitochondria-controlled signaling mechanisms of brain protection in hypoxia

    PubMed Central

    Lukyanova, Ludmila D.; Kirova, Yulia I.

    2015-01-01

    The article is focused on the role of the cell bioenergetic apparatus, mitochondria, involved in development of immediate and delayed molecular mechanisms for adaptation to hypoxic stress in brain cortex. Hypoxia induces reprogramming of respiratory chain function and switching from oxidation of NAD-related substrates (complex I) to succinate oxidation (complex II). Transient, reversible, compensatory activation of respiratory chain complex II is a major mechanism of immediate adaptation to hypoxia necessary for (1) succinate-related energy synthesis in the conditions of oxygen deficiency and formation of urgent resistance in the body; (2) succinate-related stabilization of HIF-1α and initiation of its transcriptional activity related with formation of long-term adaptation; (3) succinate-related activation of the succinate-specific receptor, GPR91. This mechanism participates in at least four critical regulatory functions: (1) sensor function related with changes in kinetic properties of complex I and complex II in response to a gradual decrease in ambient oxygen concentration; this function is designed for selection of the most efficient pathway for energy substrate oxidation in hypoxia; (2) compensatory function focused on formation of immediate adaptive responses to hypoxia and hypoxic resistance of the body; (3) transcriptional function focused on activated synthesis of HIF-1 and the genes providing long-term adaptation to low pO2; (4) receptor function, which reflects participation of mitochondria in the intercellular signaling system via the succinate-dependent receptor, GPR91. In all cases, the desired result is achieved by activation of the succinate-dependent oxidation pathway, which allows considering succinate as a signaling molecule. Patterns of mitochondria-controlled activation of GPR-91- and HIF-1-dependent reaction were considered, and a possibility of their participation in cellular-intercellular-systemic interactions in hypoxia and adaptation was

  19. Cellular and Humoral Mechanisms Involved in the Control of Tuberculosis

    PubMed Central

    Zuñiga, Joaquin; Torres-García, Diana; Santos-Mendoza, Teresa; Rodriguez-Reyna, Tatiana S.; Granados, Julio; Yunis, Edmond J.

    2012-01-01

    Mycobacterium tuberculosis (Mtb) infection is a major international public health problem. One-third of the world's population is thought to have latent tuberculosis, a condition where individuals are infected by the intracellular bacteria without active disease but are at risk for reactivation, if their immune system fails. Here, we discuss the role of nonspecific inflammatory responses mediated by cytokines and chemokines induced by interaction of innate receptors expressed in macrophages and dendritic cells (DCs). We also review current information regarding the importance of several cytokines including IL-17/IL-23 in the development of protective cellular and antibody-mediated protective responses against Mtb and their influence in containment of the infection. Finally, in this paper, emphasis is placed on the mechanisms of failure of Mtb control, including the immune dysregulation induced by the treatment with biological drugs in different autoimmune diseases. Further functional studies, focused on the mechanisms involved in the early host-Mtb interactions and the interplay between host innate and acquired immunity against Mtb, may be helpful to improve the understanding of protective responses in the lung and in the development of novel therapeutic and prophylactic tools in TB. PMID:22666281

  20. Passive Flow Separation Control Mechanism Inspired by Shark Skin

    NASA Astrophysics Data System (ADS)

    Oakley, India; Lang, Amy

    2015-11-01

    The following experimental work seeks to examine shark scales as passive flow-actuated separation control mechanisms. It is hypothesized that the actuation of these scales can in fact reduce pressure drag by inhibiting flow reversal and thereby prevent flow separation. In order to examine this mechanism at a fundamental level, three-dimensional sharkskin scales were simplified and modeled as two-dimensional flaps. To further simplify the experiment, the flaps were observed within a laminar boundary layer. The laminar boundary layer was grown over a long flat plate that was placed inside a water tunnel. A rotating cylinder was also used to induce an unsteady, increasing adverse pressure gradient, which generated a reversing flow. In order to visualize the potential actuation of the two-dimensional flaps DPIV (digital particle image velocimetry) was utilized. Three main objectives for this work included, the actuation of the two-dimensional flaps, the resistance to a reversed flow as a result of flap actuation and the prevention of flow separation. However once the experiment was conducted the flaps did not perform as previously hypothesized. The adverse pressure gradient induced by the rotating cylinder did not produce a reversing flow powerful enough to actuate the flaps. NSF REU Site Award 1358991.

  1. Internal Control Rod Drive Mechanisms, Design Options for IRIS

    SciTech Connect

    Conway, Lawrence E.; Petrovic, Bojan

    2004-07-01

    IRIS (International Reactor Innovative and Secure) is a medium-power (335 MWe) PWR with an integral, primary circuit configuration, where all the reactor coolant system components are contained within the reactor vessel. This integral configuration is a key reason for the success of IRIS' 'safety-by-design' approach, whereby accident initiators are eliminated or the accident consequences and/or frequency are reduced. The most obvious example of the IRIS safety by design approach is the elimination of large LOCA's, since the integral reactor coolant system has no large loop piping. Another serious accident scenario that is being addressed in IRIS is the postulated ejection of a reactor control cluster assembly (RCCA). This accident initiator can be eliminated by locating the RCCA drive mechanisms (CRDMs) inside the reactor vessel. This eliminates the mechanical drive rod penetration between the RCCA and the external CRDM, eliminating the potential for differential pressure across the pressure boundary, and thus eliminating 'by design' the possibility for rod ejection accident. Moreover, the elimination of the 'large' drive-rod penetrations and the external CRDM pressure housings decreases the likelihood of boric acid leakage and subsequent corrosion of the reactor pressure boundary (like the Davis-Besse incident). This paper will discuss the IRIS top level design requirements and objectives for internal CRDMs, and provide examples candidate designs and their specific performance characteristics. (authors)

  2. Fusobacterium necrophorum infections: virulence factors, pathogenic mechanism and control measures.

    PubMed

    Tan, Z L; Nagaraja, T G; Chengappa, M M

    1996-01-01

    Fusobacterium necrophorum, a Gram-negative, non-spore-forming anaerobe, is a normal inhabitant of the alimentary tract of animals and humans. Two types of F. necrophorum, subspecies necrophorum (biotype A) and funduliforme (biotype B), have been recognized, which differ morphologically, biochemically, and biologically. The organism is an opportunistic pathogen that causes numerous necrotic conditions (necrobacillosis) such as bovine hepatic abscesses, ruminant foot abscesses and human oral infections. The pathogenic mechanism of F. necrophorum is complex and not well defined. Several toxins, such as leukotoxin, endotoxin, haemolysin, haemagglutinin and adhesin, have been implicated as virulence factors. Among these, leukotoxin and endotoxin are believed to be more important than other toxins in overcoming the host's defence mechanisms to establish the infection. F. necrophorum is encountered frequently in mixed infections and, therefore, synergisms between F. necrophorum and other pathogens may play an important role in infection. Several investigators have attempted to induce protective immunity against F. necrophorum using bacterins, toxoids, and other cytoplasmic components. Generally, none of the immunogens has afforded satisfactory protection against Fusobacterium infections. Because of the unavailability of suitable immunoprophylaxis, the control of F. necrophorum infection has depended mainly on the use of antimicrobial compounds.

  3. Metallurgical Mechanisms Controlling Mechanical Properties of Aluminum Alloy 2219 Produced By Electron Beam Freeform Fabrication

    NASA Technical Reports Server (NTRS)

    Domack, Marcia S.; Taminger, Karen M. B.; Begley, Matthew

    2006-01-01

    The electron beam freeform fabrication (EBF3) layer-additive manufacturing process has been developed to directly fabricate complex geometry components. EBF3 introduces metal wire into a molten pool created on the surface of a substrate by a focused electron beam. Part geometry is achieved by translating the substrate with respect to the beam to build the part one layer at a time. Tensile properties have been demonstrated for electron beam deposited aluminum and titanium alloys that are comparable to wrought products, although the microstructures of the deposits exhibit features more typical of cast material. Understanding the metallurgical mechanisms controlling mechanical properties is essential to maximizing application of the EBF3 process. In the current study, mechanical properties and resulting microstructures were examined for aluminum alloy 2219 fabricated over a range of EBF3 process variables. Material performance was evaluated based on tensile properties and results were compared with properties of Al 2219 wrought products. Unique microstructures were observed within the deposited layers and at interlayer boundaries, which varied within the deposit height due to microstructural evolution associated with the complex thermal history experienced during subsequent layer deposition. Microstructures exhibited irregularly shaped grains, typically with interior dendritic structures, which were described based on overall grain size, morphology, distribution, and dendrite spacing, and were correlated with deposition parameters. Fracture features were compared with microstructural elements to define fracture paths and aid in definition of basic processing-microstructure-property correlations.

  4. Metallurgical Mechanisms Controlling Mechanical Properties of Aluminum Alloy 2219 Produced by Electron Beam Freeform Fabrication

    NASA Technical Reports Server (NTRS)

    Domack, Marcia S.; Tainger, Karen M.

    2006-01-01

    The electron beam freeform fabrication (EBF3) layer-additive manufacturing process has been developed to directly fabricate complex geometry components. EBF3 introduces metal wire into a molten pool created on the surface of a substrate by a focused electron beam. Part geometry is achieved by translating the substrate with respect to the beam to build the part one layer at a time. Tensile properties demonstrated for electron beam deposited aluminum and titanium alloys are comparable to wrought products, although the microstructures of the deposits exhibit cast features. Understanding the metallurgical mechanisms controlling mechanical properties is essential to maximizing application of the EBF3 process. Tensile mechanical properties and microstructures were examined for aluminum alloy 2219 fabricated over a range of EBF3 process variables. Unique microstructures were observed within the deposited layers and at interlayer boundaries, which varied within the deposit height due to microstructural evolution associated with the complex thermal history experienced during subsequent layer deposition. Microstructures exhibited irregularly shaped grains with interior dendritic structures, described based on overall grain size, morphology, distribution, and dendrite spacing, and were correlated with deposition parameters. Fracture features were compared with microstructural elements to define fracture paths and aid in definition of basic processing-microstructure-property correlations.

  5. A presynaptic gain control mechanism fine-tunes olfactory behavior.

    PubMed

    Root, Cory M; Masuyama, Kaoru; Green, David S; Enell, Lina E; Nässel, Dick R; Lee, Chi-Hon; Wang, Jing W

    2008-07-31

    Early sensory processing can play a critical role in sensing environmental cues. We have investigated the physiological and behavioral function of gain control at the first synapse of olfactory processing in Drosophila. Olfactory receptor neurons (ORNs) express the GABA(B) receptor (GABA(B)R), and its expression expands the dynamic range of ORN synaptic transmission that is preserved in projection neuron responses. Strikingly, each ORN channel has a unique baseline level of GABA(B)R expression. ORNs that sense the aversive odorant CO(2) do not express GABA(B)Rs and do not have significant presynaptic inhibition. In contrast, pheromone-sensing ORNs express a high level of GABA(B)Rs and exhibit strong presynaptic inhibition. Furthermore, pheromone-dependent mate localization is impaired in flies that lack GABA(B)Rs in specific ORNs. These findings indicate that different olfactory receptor channels employ heterogeneous presynaptic gain control as a mechanism to allow an animal's innate behavioral responses to match its ecological needs.

  6. Shark Skin Bristling as a Passive Mechanism for Separation Control

    NASA Astrophysics Data System (ADS)

    Wheelus, Jennifer; Lang, Amy; Jones, Emily

    2011-11-01

    The skin of fast-swimming sharks is proposed to have mechanisms to reduce drag and delay flow separation. The skin of fast-swimming and agile sharks is covered with small teeth-like denticles on the order of 0.2 mm. The shortfin mako is one of the fastest and most agile ocean predators creating the need to minimize its pressure drag by controlling flow separation. Biological studies of the shortfin mako skin have shown the passive bristling angle of their denticles to exceed 50 degrees in areas on the flank corresponding to the locations likely to experience separation first. It is proposed that reversing flow, as occurs at the onset of separation in a turbulent boundary layer, would activate denticle bristling and hinder local separation from leading to global separation over the shark. This study focuses on the denticle reaction to various reversed flow conditions using a pulsating jet. Mako shark skin was subjected to numerous reversed flow velocities to determine the bristling onset velocity. Digital Particle Image Velocimetry (DPIV) and digital video were used to determine the flow conditions and denticle behavior. The effect of reversed flow velocity on denticle bristling and its relation to separation control will be discussed. Research funded by NSF (award 0932352).

  7. Investigation of the Profile Control Mechanisms of Dispersed Particle Gel

    PubMed Central

    Zhao, Guang; Dai, Caili; Zhao, Mingwei

    2014-01-01

    Dispersed particle gel (DPG) particles of nano- to micron- to mm-size have been prepared successfully and will be used for profile control treatment in mature oilfields. The profile control and enhanced oil recovery mechanisms of DPG particles have been investigated using core flow tests and visual simulation experiments. Core flow test results show that DPG particles can easily be injected into deep formations and can effectively plug the high permeability zones. The high profile improvement rate improves reservoir heterogeneity and diverts fluid into the low permeability zone. Both water and oil permeability were reduced when DPG particles were injected, but the disproportionate permeability reduction effect was significant. Water permeability decreases more than the oil permeability to ensure that oil flows in its own pathways and can easily be driven out. Visual simulation experiments demonstrate that DPG particles can pass directly or by deformation through porous media and enter deep formations. By retention, adsorption, trapping and bridging, DPG particles can effectively reduce the permeability of porous media in high permeability zones and divert fluid into a low permeability zone, thus improving formation profiles and enhancing oil recovery. PMID:24950174

  8. Electro-Mechanical Actuator. DC Resonant Link Controller

    NASA Technical Reports Server (NTRS)

    Schreiner, Kenneth E.

    1996-01-01

    This report summarizes the work performed on the 68 HP electro-mechanical actuator (EMA) system developed on NASA contract for the Electrical Actuation (ELA) Technology Bridging Program. The system was designed to demonstrate the capability of large, high power linear ELAs for applications such as Thrust Vector Control (TVC) on rocket engines. It consists of a motor controller, drive electronics and a linear actuator capable of up to 32,00 lbs loading at 7.4 inches/second. The drive electronics are based on the Resonant DC link concept and operate at a nominal frequency of 55 kHz. The induction motor is a specially designed high speed, low inertia motor capable of a 68 peak HP. The actuator was originally designed by MOOG Aerospace under an internal R & D program to meet Space Shuttle Main Engine (SSME) TVC requirements. The design was modified to meet this programs linear rate specification of 7.4 inches/second. The motor and driver were tested on a dynamometer at the Martin Marietta Space Systems facility. System frequency response, step response and force-velocity tests were conducted at the MOOG Aerospace facility. A complete description of the system and all test results can be found in the body of the report.

  9. Redox Control of Leukemia: From Molecular Mechanisms to Therapeutic Opportunities

    PubMed Central

    Irwin, Mary E.; Rivera-Del Valle, Nilsa

    2013-01-01

    Abstract Reactive oxygen species (ROS) play both positive and negative roles in the proliferation and survival of a cell. This dual nature has been exploited by leukemia cells to promote growth, survival, and genomic instability—some of the hallmarks of the cancer phenotype. In addition to altered ROS levels, many antioxidants are dysregulated in leukemia cells. Together, the production of ROS and the expression and activity of antioxidant enzymes make up the primary redox control of leukemia cells. By manipulating this system, leukemia cells gain proliferative and survival advantages, even in the face of therapeutic insults. Standard treatment options have improved leukemia patient survival rates in recent years, although relapse and the development of resistance are persistent challenges. Therapies targeting the redox environment show promise for these cases. This review highlights the molecular mechanisms that control the redox milieu of leukemia cells. In particular, ROS production by the mitochondrial electron transport chain, NADPH oxidase, xanthine oxidoreductase, and cytochrome P450 will be addressed. Expression and activation of antioxidant enzymes such as superoxide dismutase, catalase, heme oxygenase, glutathione, thioredoxin, and peroxiredoxin are perturbed in leukemia cells, and the functional consequences of these molecular alterations will be described. Lastly, we delve into how these pathways can be potentially exploited therapeutically to improve treatment regimens and promote better outcomes for leukemia patients. Antioxid. Redox Signal. 18, 1349–1383. PMID:22900756

  10. Compositional, mechanical and hydrologic controls on fault slip behavior

    NASA Astrophysics Data System (ADS)

    Ikari, Matt J.

    In order to examine the roles of a variety of factors that are likely important in regulating the occurrence or lack of seismic slip, I evaluate the results of numerous laboratory studies of fault behavior, focusing on the effects of fault mineralogy, mechanical effects, and interactions between fluids and faulting processes. More specifically, these experiments are designed to investigate the underlying mechanisms controlling the transition from aseismic slip at shallow levels in the crust to seismic slip at depth, known as the updip limit of the seismogenic zone. Results of laboratory experiments indicate that mineralogy of fault gouge is a major control on fault behavior. The clay mineral montmorillonite (smectite) has been noted for its potential effect on seismogenesis in subduction zones (as well as all faults in general) due to its ability to take up water in its crystal structure. Dehydration of montmorillonite tends to increase its frictional strength as well as increase its propensity for seismic slip, as documented by a decrease in the frictional velocity dependence parameter a-b. However, the observed decrease in a-b is assisted by both increasing relative quartz percentage and increasing normal stress, implying that the onset of seismic behavior with increasing depth should not be attributed solely to smectite dehydration. Furthermore, clay-rich gouges in general, including those consisting of montmorillonite, illite, and chlorite, are both frictionally weak (mu < 0.35) and velocity-strengthening (frictionally stable, a-b > 0) at fluid-saturated conditions and effective normal stresses up to ˜60 MPa. Sheared gouges may also exhibit low fault-perpendicular permeability (k < 1x10-18), making them candidates to host high pore pressure. This indicates that faults containing granular, clay-rich gouges are unlikely to show seismic behavior, due their velocity-strengthening nature and stabilizing hydro-mechanical effects resulting from low permeability. In

  11. Rheological controls on the terrestrial core formation mechanism

    NASA Astrophysics Data System (ADS)

    Golabek, G. J.; Gerya, T. V.; Ziethe, R.; Kaus, B. J. P.; Tackley, P. J.

    2009-04-01

    Knowledge about the terrestrial core formation mechanism is still very limited. The fracturing mechanism was proposed for cold planetary interiors surrounded by an iron layer [Stevenson, 1981], which develops from an overlying magma ocean. In this case the cold central region is displaced by a degree one mode from the centre of the accreting planet and fractured due to the large stresses. In contrast the consideration of short-lived radioactive heating may result in warmer central regions and the preference of higher mode iron diapirism as core formation mechanism [e.g. Rubie et al., 2007; Ziethe and Spohn, 2007]. Until now most numerical models of core formation via diapirism were limited to the simulation of the sinking of a single diapir. We perform 2D cylindrical simulations using the code I2ELVIS applying the newly developed "spherical-Cartesian" methodology [Gerya and Yuen, 2007]. It combines finite differences on a fully staggered rectangular Eulerian grid and Lagrangian marker-in-cell technique for solving momentum, continuity and temperature equations as well as the Poisson equation for gravity potential in a self-gravitating planetary body. In the model the planet is surrounded by a low viscosity, massless fluid ("sticky air") to simulate a free surface [Schmeling et al., 2008]. We apply a temperature- and stress-dependent viscoplastic rheology inside Mars- and Earth-sized planets and include heat release due to radioactive decay, shear and adiabatic heating. As initial condition we use randomly distributed iron diapirs with random sizes in the range 50 to 100 km radius inside the accreting planet, which represent the iron delivered by predifferentiated impactors. A systematic investigation of the diapir behaviour for different activation volumes and Peierls stresses is being performed, and results are being compared to the isotopic time scale of core formation on terrestrial planets. We show that the rheology controls which formation mechanism becomes

  12. Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis

    NASA Technical Reports Server (NTRS)

    Ingber, D. E.; Prusty, D.; Sun, Z.; Betensky, H.; Wang, N.

    1995-01-01

    Capillary endothelial cells can be switched between growth and differentiation by altering cell-extracellular matrix interactions and thereby, modulating cell shape. Studies were carried out to determine when cell shape exerts its growth-regulatory influence during cell cycle progression and to explore the role of cytoskeletal structure and mechanics in this control mechanism. When G0-synchronized cells were cultured in basic fibroblast growth factor (FGF)-containing defined medium on dishes coated with increasing densities of fibronectin or a synthetic integrin ligand (RGD-containing peptide), cell spreading, nuclear extension, and DNA synthesis all increased in parallel. To determine the minimum time cells must be adherent and spread on extracellular matrix (ECM) to gain entry into S phase, cells were removed with trypsin or induced to retract using cytochalasin D at different times after plating. Both approaches revealed that cells must remain extended for approximately 12-15 h and hence, most of G1, in order to enter S phase. After this restriction point was passed, normally 'anchorage-dependent' endothelial cells turned on DNA synthesis even when round and in suspension. The importance of actin-containing microfilaments in shape-dependent growth control was confirmed by culturing cells in the presence of cytochalasin D (25-1000 ng ml-1): dose-dependent inhibition of cell spreading, nuclear extension, and DNA synthesis resulted. In contrast, induction of microtubule disassembly using nocodazole had little effect on cell or nuclear spreading and only partially inhibited DNA synthesis. Interestingly, combination of nocodazole with a suboptimal dose of cytochalasin D (100 ng ml-1) resulted in potent inhibition of both spreading and growth, suggesting that microtubules are redundant structural elements which can provide critical load-bearing functions when microfilaments are partially compromised. Similar synergism between nocodazole and cytochalasin D was observed

  13. Special Admissions Students: Dis-Engaged from the Educational Enterprise.

    ERIC Educational Resources Information Center

    Hinchcliff-Pelias, Mary; Lind, Scott L.; Treinen, Kristen P.

    Special admissions programs may offer access into higher education for students who, for various reasons, do not meet the institutions' standard admissions criteria. Once the special admissions status has been granted, these programs provide support to these students. This paper is not a critique of special admissions programs in general or…

  14. 6 CFR 17.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Preference in admission. 17.305 Section 17.305... the Basis of Sex in Admission and Recruitment Prohibited § 17.305 Preference in admission. A recipient to which §§ 17.300 through 17.310 apply shall not give preference to applicants for admission, on...

  15. 49 CFR 25.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Preference in admission. 25.305 Section 25.305... Admission and Recruitment Prohibited § 25.305 Preference in admission. A recipient to which §§ 25.300 through 25.310 apply shall not give preference to applicants for admission, on the basis of attendance...

  16. 22 CFR 229.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Preference in admission. 229.305 Section 229... in Admission and Recruitment Prohibited § 229.305 Preference in admission. A recipient to which §§ 229.300 through 229.310 apply shall not give preference to applicants for admission, on the basis...

  17. 43 CFR 41.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Preference in admission. 41.305 Section 41... Basis of Sex in Admission and Recruitment Prohibited § 41.305 Preference in admission. A recipient to which §§ 41.300 through 41.310 apply shall not give preference to applicants for admission, on the...

  18. 15 CFR 8a.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Preference in admission. 8a.305... on the Basis of Sex in Admission and Recruitment Prohibited § 8a.305 Preference in admission. A recipient to which §§ 8a.300 through 8a.310 apply shall not give preference to applicants for admission,...

  19. 22 CFR 146.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Preference in admission. 146.305 Section 146... in Admission and Recruitment Prohibited § 146.305 Preference in admission. A recipient to which §§ 146.300 through 146.310 apply shall not give preference to applicants for admission, on the basis...

  20. 41 CFR 101-4.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Preference in admission... in Admission and Recruitment Prohibited § 101-4.305 Preference in admission. A recipient to which §§ 101-4.300 through 101-4.310 apply shall not give preference to applicants for admission, on the...

  1. 45 CFR 86.22 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Preference in admission. 86.22 Section 86.22... on the Basis of Sex in Admission and Recruitment Prohibited § 86.22 Preference in admission. A recipient to which this subpart applies shall not give preference to applicants for admission, on the...

  2. 40 CFR 5.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Preference in admission. 5.305 Section... on the Basis of Sex in Admission and Recruitment Prohibited § 5.305 Preference in admission. A recipient to which §§ 5.300 through 5.310 apply shall not give preference to applicants for admission,...

  3. 31 CFR 28.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Preference in admission. 28.305... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 28.305 Preference in admission. A recipient to which §§ 28.300 through 28.310 apply shall not give preference to applicants for admission,...

  4. 34 CFR 104.42 - Admissions and recruitment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Admissions and recruitment. 104.42 Section 104.42... ASSISTANCE Postsecondary Education § 104.42 Admissions and recruitment. (a) General. Qualified handicapped... admission or recruitment by a recipient to which this subpart applies. (b) Admissions. In administering...

  5. 15 CFR 8b.20 - Admission and recruitment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Admission and recruitment. 8b.20... Secondary Education § 8b.20 Admission and recruitment. (a) General. Qualified handicapped may not, on the basis of handicap, be denied admission or be subjected to discrimination in admission or recruitment...

  6. Efficacy versus Equity: What Happens When States Tinker With College Admissions in a Race-Blind Era?

    ERIC Educational Resources Information Center

    Black, Sandra E.; Cortes, Kalena E.; Lincove, Jane Arnold

    2016-01-01

    We investigate the efficacy and equity of college admissions criteria by estimating the effect of multiple measures of college readiness on college performance in the context of race-blind automatic admissions policies. We take advantage of a unique institutional feature of the Texas higher education system to control for selection into…

  7. Topology optimization of 3D compliant actuators by a sequential element rejection and admission method

    NASA Astrophysics Data System (ADS)

    Ansola, R.; Veguería, E.; Alonso, C.; Querin, O. M.

    2016-03-01

    This work presents a sequential element rejection and admission (SERA) method for optimum topology design of three dimensional compliant actuators. The proposed procedure has been successfully applied to several topology optimization problems, but most investigations for compliant devices design have been focused on planar systems. This investigation aims to progress on this line, where a generalization of the method for three dimensional topology optimization is explored. The methodology described in this work is useful for the synthesis of high performance flexure based micro and nano manipulation applications demanding for both sensing and control of motion and force trajectories. In this case the goal of the topology optimization problem is to design an actuator that transfers work from the input point to the output port in a structurally efficient way. Here we will use the classical formulation where the displacement performed on a work piece modelled by a spring is maximized. The technique implemented works with two separate criteria for the rejection and admission of elements to efficiently achieve the optimum design and overcomes problems encountered by other evolutionary methods when dealing with compliant mechanisms design. The use of the algorithm is demonstrated through several numerical examples.

  8. A study of admissions and inpatients over the Christmas period using the appropriateness evaluation protocol (AEP).

    PubMed

    Henshaw; Pollock; Rai; Gluck

    2000-08-01

    The aim of the study was to examine appropriateness of admissions and inpatients over Christmas especially in the elderly. The study was a prospective audit of admissions and inpatients to the Whittington Hospital. The main outcome measures were appropriateness of admission or day of hospital residence using the Appropriateness Evaluation Protocol. The protocol was applied to admissions and inpatients over Christmas and control periods. The results showed that there was a significant difference in the number of elderly admissions between the control period and Christmas period, 94 (34%) vs. 104 (43%) (P=0.02). However there was no corresponding change in appropriateness of elderly admissions, ten (10.6%) vs. six (5.8%), (P=0.2). The inappropriateness of day of hospital residence increased from 10% on the control day to 20% on the study day (P=0.02). In conclusion elderly patients are not admitted more inappropriately over Christmas but their discharge at this time appears to be delayed resulting in inappropriate bed use.

  9. Hospital Admission Patterns in Children with CAH: Admission Rates and Adrenal Crises Decline with Age

    PubMed Central

    Rushworth, R. Louise; Falhammar, Henrik; Munns, Craig F.; Maguire, Ann M.; Torpy, David J.

    2016-01-01

    Objective. To examine patterns of hospitalisation for acute medical conditions in children with congenital adrenal hyperplasia (CAH). Design. A retrospective study of hospitalisation using administrative data. Setting. All hospitals in NSW, Australia. Patients. All patients admitted with CAH and a random sample of admissions in patients aged 0 to 18 years without adrenal insufficiency (AI). Main Outcome Measures. Admissions and comorbidities by age and sex. Results. Of 573 admissions for medical problems in CAH children, 286 (49.9%) were in males, and 236 (41.2%) had a principal diagnosis of CAH or had an adrenal crisis (AC). 37 (6.5%) ACs were recorded. An infection was found in 43.5% (n = 249) of the CAH patient admissions and 51.7% (n = 1613) of the non-AI group, p < 0.001. Children aged up to one year had the highest number of admissions (n = 149) and six ACs (four in males). There were 21 ACs recorded for children aged 1–5 years. Older CAH children had fewer admissions and fewer ACs. No in-hospital deaths were recorded. Conclusions. Admission for medical problems in CAH children declines with age. An AC was recorded in 6.5% of the admissions, with the majority of ACs occurring in the 1 to 5 years age group and there were no deaths. PMID:26880914

  10. Assessing Practical Intelligence in Business School Admissions: A Supplement to the Graduate Management Admissions Test

    ERIC Educational Resources Information Center

    Hedlund, Jennifer; Wilt, Jeanne M.; Nebel, Kristina L.; Ashford, Susan J.; Sternberg, Robert J.

    2006-01-01

    The Graduate Management Admission Test (GMAT) is the most widely used measure of managerial potential in MBA admissions. GMAT scores, although predictive of grades in business school, leave much of the variance in graduate school performance unexplained. The GMAT also produces disparities in test scores between groups, generating the potential for…

  11. PLETHORA Genes Control Regeneration by a Two-Step Mechanism.

    PubMed

    Kareem, Abdul; Durgaprasad, Kavya; Sugimoto, Kaoru; Du, Yujuan; Pulianmackal, Ajai J; Trivedi, Zankhana B; Abhayadev, Pazhoor V; Pinon, Violaine; Meyerowitz, Elliot M; Scheres, Ben; Prasad, Kalika

    2015-04-20

    Regeneration, a remarkable example of developmental plasticity displayed by both plants and animals, involves successive developmental events driven in response to environmental cues. Despite decades of study on the ability of the plant tissues to regenerate a complete fertile shoot system after inductive cues, the mechanisms by which cells acquire pluripotency and subsequently regenerate complete organs remain unknown. Here, we show that three PLETHORA (PLT) genes, PLT3, PLT5, and PLT7, regulate de novo shoot regeneration in Arabidopsis by controlling two distinct developmental events. Cumulative loss of function of these three genes causes the intermediate cell mass, callus, to be incompetent to form shoot progenitors, whereas induction of PLT5 or PLT7 can render shoot regeneration hormone-independent. We further show that PLT3, PLT5, and PLT7 establish pluripotency by activating root stem cell regulators PLT1 and PLT2, as reconstitution of either PLT1 or PLT2 in the plt3; plt5-2; plt7 mutant re-established the competence to regenerate shoot progenitor cells but did not lead to the completion of shoot regeneration. PLT3, PLT5, and PLT7 additionally regulate and require the shoot-promoting factor CUP-SHAPED COTYLEDON2 (CUC2) to complete the shoot-formation program. Our findings uncouple the acquisition of competence to regenerate shoot progenitor cells from completion of shoot formation, indicating a two-step mechanism of de novo shoot regeneration that operates in all tested plant tissues irrespective of their origin. Our studies reveal intermediate developmental phases of regeneration and provide a deeper understanding into the mechanistic basis of regeneration.

  12. Cell cycle control, checkpoint mechanisms, and genotoxic stress.

    PubMed Central

    Shackelford, R E; Kaufmann, W K; Paules, R S

    1999-01-01

    The ability of cells to maintain genomic integrity is vital for cell survival and proliferation. Lack of fidelity in DNA replication and maintenance can result in deleterious mutations leading to cell death or, in multicellular organisms, cancer. The purpose of this review is to discuss the known signal transduction pathways that regulate cell cycle progression and the mechanisms cells employ to insure DNA stability in the face of genotoxic stress. In particular, we focus on mammalian cell cycle checkpoint functions, their role in maintaining DNA stability during the cell cycle following exposure to genotoxic agents, and the gene products that act in checkpoint function signal transduction cascades. Key transitions in the cell cycle are regulated by the activities of various protein kinase complexes composed of cyclin and cyclin-dependent kinase (Cdk) molecules. Surveillance control mechanisms that check to ensure proper completion of early events and cellular integrity before initiation of subsequent events in cell cycle progression are referred to as cell cycle checkpoints and can generate a transient delay that provides the cell more time to repair damage before progressing to the next phase of the cycle. A variety of cellular responses are elicited that function in checkpoint signaling to inhibit cyclin/Cdk activities. These responses include the p53-dependent and p53-independent induction of Cdk inhibitors and the p53-independent inhibitory phosphorylation of Cdk molecules themselves. Eliciting proper G1, S, and G2 checkpoint responses to double-strand DNA breaks requires the function of the Ataxia telangiectasia mutated gene product. Several human heritable cancer-prone syndromes known to alter DNA stability have been found to have defects in checkpoint surveillance pathways. Exposures to several common sources of genotoxic stress, including oxidative stress, ionizing radiation, UV radiation, and the genotoxic compound benzo[a]pyrene, elicit cell cycle

  13. Catalytic Synthesis of Oxygenates: Mechanisms, Catalysts and Controlling Characteristics

    SciTech Connect

    Klier, Kamil; Herman, Richard G

    2005-11-30

    This research focused on catalytic synthesis of unsymmetrical ethers as a part of a larger program involving oxygenated products in general, including alcohols, ethers, esters, carboxylic acids and their derivatives that link together environmentally compliant fuels, monomers, and high-value chemicals. The catalysts studied here were solid acids possessing strong Brnsted acid functionalities. The design of these catalysts involved anchoring the acid groups onto inorganic oxides, e.g. surface-grafted acid groups on zirconia, and a new class of mesoporous solid acids, i.e. propylsulfonic acid-derivatized SBA-15. The former catalysts consisted of a high surface concentration of sulfate groups on stable zirconia catalysts. The latter catalyst consists of high surface area, large pore propylsulfonic acid-derivatized silicas, specifically SBA-15. In both cases, the catalyst design and synthesis yielded high concentrations of acid sites in close proximity to one another. These materials have been well-characterization in terms of physical and chemical properties, as well as in regard to surface and bulk characteristics. Both types of catalysts were shown to exhibit high catalytic performance with respect to both activity and selectivity for the bifunctional coupling of alcohols to form ethers, which proceeds via an efficient SN2 reaction mechanism on the proximal acid sites. This commonality of the dual-site SN2 reaction mechanism over acid catalysts provides for maximum reaction rates and control of selectivity by reaction conditions, i.e. pressure, temperature, and reactant concentrations. This research provides the scientific groundwork for synthesis of ethers for energy applications. The synthesized environmentally acceptable ethers, in part derived from natural gas via alcohol intermediates, exhibit high cetane properties, e.g. methylisobutylether with cetane No. of 53 and dimethylether with cetane No. of 55-60, or high octane properties, e.g. diisopropylether with

  14. PLETHORA Genes Control Regeneration by a Two-step Mechanism

    PubMed Central

    Kareem, Abdul; Durgaprasad, Kavya; Sugimoto, Kaoru; Du, Yujuan; Pulianmackal, Ajai J.; Trivedi, Zankhana B.; Abhayadev, Pazhoor V.; Pinon, Violaine; Meyerowitz, Elliot M.; Scheres, Ben; Prasad, Kalika

    2016-01-01

    Summary Background Regeneration, a remarkable example of developmental plasticity displayed by both plants and animals, involves successive developmental events driven in response to environmental cues. Despite decades of study on the ability of the plant tissues to regenerate complete fertile shoot system after inductive cues, the mechanisms by which cells acquire pluripotency and subsequently regenerate complete organs remain unknown. Results Here we show that three PLETHORA (PLT) genes, PLT3, PLT5 and PLT7 regulate de novo shoot regeneration in Arabidopsis by controlling two distinct developmental events. Cumulative loss of function of these three genes causes the intermediate cell mass, callus, to be incompetent to form shoot progenitors, whereas induction of PLT5 or PLT7 can render shoot regeneration hormone-independent. We further show that PLT3, PLT5 and PLT7 establish pluripotency by activating root stem cell regulators PLT1 and PLT2, as reconstitution of either PLT1 or PLT2 in the plt3; plt5-2; plt7 mutant re-established the competence to regenerate shoot progenitor cells, but did not lead to the completion of shoot regeneration. PLT3, PLT5 and PLT7 additionally regulate and require the shoot-promoting factor CUP-SHAPED COTYLEDON2 to complete the shoot formation program. Conclusions Our findings uncouple the acquisition of competence to regenerate shoot progenitor cells from completion of shoot formation, indicating a two-step mechanism of de novo shoot regeneration that operates in all tissues irrespective of their origin. Our studies reveal intermediate developmental phases of regeneration and provide a deeper understanding into the mechanistic basis of regeneration. PMID:25819565

  15. Laboratory Investigations into Micromechanical Mechanisms Controlling Earthquake Nucleation

    NASA Astrophysics Data System (ADS)

    Selvadurai, P. A.; Glaser, S. D.; Kiwan, R. H.

    2013-12-01

    Improving our understanding of factors controlling spontaneous shear rupture nucleation on a frictional fault would help better define the important physical processes contributing to earthquake rupture and faulting. Our current laboratory investigations quantify the local stress states on a laboratory fault, which control the transition of sliding from stable (quasi-static) to unstable (dynamic), commonly referred to as earthquake nucleation. A fault is experimentally modeled using two Poly(methyl methacrylate) samples in a direct shear configuration. During nucleation, we observed sudden, elastodynamic stress changes using an array of 16 acoustic emission (AE) sensors. Measurements of absolute displacement from these sensors allowed us to characterize general source mechanics using moment tensor inversion. This technique is widely used in seismology and we observe double-couple (DC) focal mechanisms; a source commonly used to characterize in situ earthquakes. During nucleation, we sometimes observe swarms of smaller, ';foreshock' earthquakes (Mw ~ -7), localized in time and space, prior to the incipient mainshock (Mw ~ -3.25). In general, the local perturbations in the stress field induced by the stress drop (Δσ) from a single foreshock was insufficient to cause the subsequent foreshock at the spatial distances recorded experimentally. This implied that the underlying process driving the foreshock sequence (and eventual mainshock) was aseismic slip over the nucleation zone recorded using non-contact sensors. Spatio-temporal distributions of the foreshocks and the near-fault aseismic motions were shown to be directly related to: i) the rate at which the average bulk stress accumulates across the fault (dτf /dt) and ii) the heterogeneity of normal stress caused by the irregular distribution of asperities, respectively. (A) Locations of the foreshocks (FS1-FS9) determined using p-wave travel times from multiple AE sensors. The locations were superimposed on

  16. Impact of tornadoes on hospital admissions for acute cardiovascular events

    PubMed Central

    Silva-Palacios, Federico; Casanegra, Ana Isabel; Shapiro, Alan; Phan, Minh; Hawkins, Beau; Li, Ji; Stoner, Julie; Tafur, Alfonso

    2016-01-01

    Background There is a paucity of data describing cardiovascular events after tornado outbreaks. We proposed to study the effects of tornadoes on the incidence of cardiovascular events at a tertiary care institution. Population and methods Hospital admission records from a single center situated in a tornado-prone area three months before and after a 2013 tornado outbreak were abstracted. To control for seasonal variation, we also abstracted data from the same period of the prior year (control). Hospital admissions for cardiovascular events (CVEs) including acute myocardial infarction, stroke and venous thromboembolism (VTE) were summated by zip codes, and compared by time period. Results There were 22,607 admissions analyzed, of which 6,705 (30%), 7,980 (35%), and 7,922 (35%) were during the pre-tornado, post-tornado, and control time frames, respectively. There were 344 CVE in the controls, 317 CVE in pre-tornado and 364 CVEs in post tornado periods. There was no difference in the prevalence of CVE during the post-tornado season compared with the control (PPR = 1.05 95% CI: 0.91 to 1.21, p = 0.50) or the pre-tornado season (PPR= 0.96, 95% CI: 0.83 to 1.21, p = 0.63). Conclusion In conclusion, tornado outbreaks did not increase the prevalence of cardiovascular events. In contrast to the effect of hurricanes, implementation of a healthcare policy change directed toward the early treatment and prevention of cardiovascular events after tornadoes does not seem warranted. PMID:26388119

  17. Controlling mechanisms of moisture diffusion in convective drying of leather

    NASA Astrophysics Data System (ADS)

    Benmakhlouf, Naima; Azzouz, Soufien; Monzó-Cabrera, Juan; Khdhira, Hechmi; ELCafsi, Afif

    2016-08-01

    Leather manufacturing involves a crucial energy-intensive drying stage in the finishing process to remove its residual moisture. It occurs several times in the tanning course. As it is the target of this paper to depict an experimental way to determine moisture diffusion in the convective drying of leather. The effective diffusion coefficient is estimated by a method derived from Fick's law and by analytic method. The effective diffusion coefficients are obtained from drying tests and the diffusivity behaviour is studied versus the controlling parameter such as the convective airflow temperature. The experiments were conducted at hot air temperatures of 40, 45, 50, 55 and 60 °C and hot air speed of 1 m/s. The hot air temperature had significant effect on the effective moisture diffusivity of the leather sample. The average effective moisture diffusivity in rosehip ranged between 5.87 × 10-11 and 14.48 × 10-11 m2/s for leather at the temperatures studied. Activation energy for convective drying was found to be 38.46 kJ/mol for leather. The obtained results fully confirm the theoretical study in which an exponentially increasing relationship between effective diffusivity and temperature is predicted. The results of this study provide a better understanding of the drying mechanisms and may lead to a series of recommendations for leather drying optimization. It opens the possibility for further investigations on the description of drying conditions.

  18. Potassium channel conductance as a control mechanism in hair follicles.

    PubMed

    Buhl, A E; Conrad, S J; Waldon, D J; Brunden, M N

    1993-07-01

    The opening of intracellular potassium channels is a common mechanism of action for a set of anti-hypertensive drugs that includes the hair-growth-inducing agent minoxidil. Recent work suggests potassium channel openers (PCOs) also influence hair growth. Correlative studies demonstrate that a series of PCOs including minoxidil, pinacidil, P-1075, an active pinacidil analog, RP-49,356, cromakalim, and nicorandil maintain hair growth in cultured vibrissa follicles. Studies using balding stumptail macaques verify that minoxidil, P-1075, and cromakalim but not RP-49,356 stimulate hair growth. The definition of potassium channels and documentation of drug effects on these channels is classically done using electrophysiologic techniques. Such studies require the identification and isolation of target cells. Both these are among the unsolved problems in the area of hair biology. Estimating K+ flux using 86Rb+ as a K+ tracer is an accepted method of assessing potassium channel conductance in other organ systems. Both pinacidil and RP-49,356 induce measurable Rb+ flux in isolated vibrissa follicles and a hair epithelial cell line whereas neither minoxidil nor minoxidil sulfate had measurable effects. Potassium channels have been studied successfully in other organ systems using specific pharmacologic blockers for the various channel subtypes. Blockers including glyburide, tetraethylammonium, and procaine failed to inhibit minoxidil stimulation of cultured follicles. The current explosion of knowledge on potassium channel biology, cloning of channels, and continued progress in hair biology promise to clarify the role of K+ ions in the control of hair follicles.

  19. Controlled growth mechanism of poly (3-hexylthiophene) nanowires

    NASA Astrophysics Data System (ADS)

    Kiymaz, D.; Yagmurcukardes, M.; Tomak, A.; Sahin, H.; Senger, R. T.; Peeters, F. M.; Zareie, H. M.; Zafer, C.

    2016-11-01

    Synthesis of 1D-polymer nanowires by a self-assembly method using marginal solvents is an attractive technique. While the formation mechanism is poorly understood, this method is essential in order to control the growth of nanowires. Here we visualized the time-dependent assembly of poly (3-hexyl-thiophene-2,5-diyl) (P3HT) nanowires by atomic force microscopy and scanning tunneling microscopy. The assembly of P3HT nanowires was carried out at room temperature by mixing cyclohexanone (CHN), as a poor solvent, with polymer solution in 1,2-dichlorobenzene (DCB). Both π–π stacking and planarization, obtained at the mix volume ratio of P3HT (in DCB):CHN (10:7), were considered during the investigation. We find that the length of nanowires was determined by the ordering of polymers in the polymer repetition direction. Additionally, our density functional theory calculations revealed that the presence of DCB and CHN molecules that stabilize the structural distortions due to tail group of polymers was essential for the core-wire formation.

  20. Market-based control mechanisms for patient safety

    PubMed Central

    Coiera, E; Braithwaite, J

    2009-01-01

    A new model is proposed for enhancing patient safety using market-based control (MBC), inspired by successful approaches to environmental governance. Emissions trading, enshrined in the Kyoto protocol, set a carbon price and created a carbon market—is it possible to set a patient safety price and let the marketplace find ways of reducing clinically adverse events? To “cap and trade,” a regulator would need to establish system-wide and organisation-specific targets, based on the cost of adverse events, create a safety market for trading safety credits and then police the market. Organisations are given a clear policy signal to reduce adverse event rates, are told by how much, but are free to find mechanisms best suited to their local needs. The market would inevitably generate novel ways of creating safety credits, and accountability becomes hard to evade when adverse events are explicitly measured and accounted for in an organisation’s bottom line. PMID:19342522

  1. Weathering controls on mechanisms of carbon storage in grassland soils

    USGS Publications Warehouse

    Masiello, C.A.; Chadwick, O.A.; Southon, J.; Torn, M.S.; Harden, J.W.

    2004-01-01

    On a sequence of soils developed under similar vegetation, temperature, and precipitation conditions, but with variations in mineralogical properties, we use organic carbon and 14C inventories to examine mineral protection of soil organic carbon. In these soils, 14C data indicate that the creation of slow-cycling carbon can be modeled as occurring through reaction of organic ligands with Al3+ and Fe3+ cations in the upper horizons, followed by sorption to amorphous inorganic Al compounds at depth. Only one of these processes, the chelation Al3+ and Fe3+ by organic ligands, is linked to large carbon stocks. Organic ligands stabilized by this process traverse the soil column as dissolved organic carbon (both from surface horizons and root exudates). At our moist grassland site, this chelation and transport process is very strongly correlated with the storage and long-term stabilization of soil organic carbon. Our 14C results show that the mechanisms of organic carbon transport and storage at this site follow a classic model previously believed to only be significant in a single soil order (Spodosols), and closely related to the presence of forests. The presence of this process in the grassland Alfisol, Inceptisol, and Mollisol soils of this chronosequence suggests that this process is a more significant control on organic carbon storage than previously thought. Copyright 2004 by the American Geophysical Union.

  2. Neural Conflict–Control Mechanisms Improve Memory for Target Stimuli

    PubMed Central

    Krebs, Ruth M.; Boehler, Carsten N.; De Belder, Maya; Egner, Tobias

    2015-01-01

    According to conflict-monitoring models, conflict serves as an internal signal for reinforcing top-down attention to task-relevant information. While evidence based on measures of ongoing task performance supports this idea, implications for long-term consequences, that is, memory, have not been tested yet. Here, we evaluated the prediction that conflict-triggered attentional enhancement of target-stimulus processing should be associated with superior subsequent memory for those stimuli. By combining functional magnetic resonance imaging (fMRI) with a novel variant of a face-word Stroop task that employed trial-unique face stimuli as targets, we were able to assess subsequent (incidental) memory for target faces as a function of whether a given face had previously been accompanied by congruent, neutral, or incongruent (conflicting) distracters. In line with our predictions, incongruent distracters not only induced behavioral conflict, but also gave rise to enhanced memory for target faces. Moreover, conflict-triggered neural activity in prefrontal and parietal regions was predictive of subsequent retrieval success, and displayed conflict-enhanced functional coupling with medial-temporal lobe regions. These data provide support for the proposal that conflict evokes enhanced top-down attention to task-relevant stimuli, thereby promoting their encoding into long-term memory. Our findings thus delineate the neural mechanisms of a novel link between cognitive control and memory. PMID:24108799

  3. Weathering controls on mechanisms of carbon storage in grassland soils

    SciTech Connect

    Masiello, C.A.; Chadwick, O.A.; Southon, J.; Torn, M.S.; Harden, J.W.

    2004-09-01

    On a sequence of soils developed under similar vegetation, temperature, and precipitation conditions, but with variations in mineralogical properties, we use organic carbon and 14C inventories to examine mineral protection of soil organic carbon. In these soils, 14C data indicate that the creation of slow-cycling carbon can be modeled as occurring through reaction of organic ligands with Al3+ and Fe3+ cations in the upper horizons, followed by sorption to amorphous inorganic Al compounds at depth. Only one of these processes, the chelation of Al3+ and Fe3+ by organic ligands, is linked to large carbon stocks. Organic ligands stabilized by this process traverse the soil column as dissolved organic carbon (both from surface horizons and root exudates). At our moist grassland site, this chelation and transport process is very strongly correlated with the storage and long-term stabilization of soil organic carbon. Our 14C results show that the mechanisms of organic carbon transport and storage at this site follow a classic model previously believed to only be significant in a single soil order (Spodosols), and closely related to the presence of forests. The presence of this process in the grassland Alfisol, Inceptisol, and Mollisol soils of this chronosequence suggests that this process is a more significant control on organic carbon storage than previously thought.

  4. Wetting mechanisms of gel-based controlled-release fertilizers.

    PubMed

    Shavit, U; Reiss, M; Shaviv, A

    2003-02-14

    The release mechanism of gel-based controlled release fertilizers (CRFs) involves water penetration into dry mixtures of fertilizers and gel forming polymers. Water penetration provides an upper limit to the whole release process. Where wetting prediction is often based on models that describe the flow of the liquid phase, vapor motion may become significant when a sharp wetting front exists. In this study we examine the role of vapor and fluid flows in the wetting process of CRFs consisting of urea or KNO(3) mixed with polyacrylamide (PAM). Vapor adsorption isotherms were obtained for typical fertilizer-PAM mixtures. Wetting and release experiments were conducted by dividing the CRFs into regions alternately filled with a pure fertilizer and mixtures of PAM and fertilizer. The experiments were designed in such a way that when the wetting front reaches a mixtures interface, its motion depends on the gradient imposed by the difference in osmotic potential (OP). The coupled equations of vapor and liquid flow in initially dry conditions were solved numerically to demonstrate the conceptual understanding gained by the experiments. The results show that wetting front motion is affected by transport and adsorption of vapor. It was also shown that the release rate is different when wetting is governed by vapor flow or by liquid flow. The release pattern from a multi-regions device was consistent with the wetting pattern, demonstrating the possibility to tailor the release according to periods of peak demand. PMID:12586505

  5. Neural mechanisms of timing control in a coincident timing task.

    PubMed

    Masaki, Hiroaki; Sommer, Werner; Takasawa, Noriyoshi; Yamazaki, Katuo

    2012-04-01

    Many ball sports such as tennis or baseball require precise temporal anticipation of both sensory input and motor output (i.e., receptor anticipation and effector anticipation, respectively) and close performance monitoring. We investigated the neural mechanisms underlying timing control and performance monitoring in a coincident timing task involving both types of anticipations. Peak force for two time-to-peak force (TTP) conditions-recorded with a force-sensitive key-was required to coincide with a specific position of a stimulus rotating either slow or fast on a clock face while the contingent negative variation (CNV) and the motor-elicited negativity were recorded. Absolute timing error was generally smaller for short TTP (high velocity) conditions. CNV amplitudes increased with both faster stimulus velocity and longer TTPs possibly reflecting increased motor programming efforts. In addition, the motor-elicited negativity was largest in the slow stimulus/short TTP condition, probably representing some forms of performance monitoring as well as shorter response duration. Our findings indicate that the coincident timing task is a good model for real-life situations of tool use. PMID:22415201

  6. Wetting mechanisms of gel-based controlled-release fertilizers.

    PubMed

    Shavit, U; Reiss, M; Shaviv, A

    2003-02-14

    The release mechanism of gel-based controlled release fertilizers (CRFs) involves water penetration into dry mixtures of fertilizers and gel forming polymers. Water penetration provides an upper limit to the whole release process. Where wetting prediction is often based on models that describe the flow of the liquid phase, vapor motion may become significant when a sharp wetting front exists. In this study we examine the role of vapor and fluid flows in the wetting process of CRFs consisting of urea or KNO(3) mixed with polyacrylamide (PAM). Vapor adsorption isotherms were obtained for typical fertilizer-PAM mixtures. Wetting and release experiments were conducted by dividing the CRFs into regions alternately filled with a pure fertilizer and mixtures of PAM and fertilizer. The experiments were designed in such a way that when the wetting front reaches a mixtures interface, its motion depends on the gradient imposed by the difference in osmotic potential (OP). The coupled equations of vapor and liquid flow in initially dry conditions were solved numerically to demonstrate the conceptual understanding gained by the experiments. The results show that wetting front motion is affected by transport and adsorption of vapor. It was also shown that the release rate is different when wetting is governed by vapor flow or by liquid flow. The release pattern from a multi-regions device was consistent with the wetting pattern, demonstrating the possibility to tailor the release according to periods of peak demand.

  7. Minireview: Steroid-regulated paracrine mechanisms controlling implantation.

    PubMed

    Pawar, Sandeep; Hantak, Alison M; Bagchi, Indrani C; Bagchi, Milan K

    2014-09-01

    Implantation is an essential process during establishment of pregnancy in mammals. It is initiated with the attachment of the blastocyst to a receptive uterine epithelium followed by its invasion into the stromal tissue. These events are profoundly regulated by the steroid hormones 17β-estradiol and progesterone. During the past several years, mouse models harboring conditional gene knockout mutations have become powerful tools for determining the functional roles of cellular factors involved in various aspects of implantation biology. Studies using these genetic models as well as primary cultures of human endometrial cells have established that the estrogen receptor α, the progesterone receptor, and their downstream target genes critically regulate uterine growth and differentiation, which in turn control embryo-endometrial interactions during early pregnancy. These studies have uncovered a diverse array of molecular cues, which are produced under the influence of estrogen receptor α and progesterone receptor and exchanged between the epithelial and stromal compartments of the uterus during the progressive phases of implantation. These paracrine signals are critical for acquisition of uterine receptivity and functional interactions with the embryo. This review highlights recent work describing paracrine mechanisms that govern steroid-regulated uterine epithelial-stromal dialogue during implantation and their roles in fertility and disease. PMID:25051170

  8. Controlled mechanical fracture for fabricating microchannels with various size gradients.

    PubMed

    Kim, Hong-Nam; Lee, Sung-Hoon; Suh, Kahp-Yang

    2011-02-21

    We present a simple method to generate cracks with controllable size (depth and width) and space gradients using deep surface oxidation and anisotropic mechanical stretching. To generate a thick oxidation layer (<∼7 µm), a polydimethylsiloxane (PDMS) slab of uniform or varying thickness was exposed to UV/ozone for less than 30 min in the UV-C wavelength including wavelengths of 185 and 254 nm. Subsequently, the PDMS slab was wrapped on a cylindrical support (radius: 11 mm) to apply a uniform bending strain (<21%), resulting in equally separated, anisotropic cracks over a large area. By modulating initial oxidation depth and applied bending stress, cracks of varying sizes and spaces were formed on a single PDMS slab. Furthermore, multiple, sequential cracks were generated by increasing the strain in a step-wise fashion and multi-directional cracks by applying the strain with an orientation angle. Finally, size and space-varying cracks were formed between two adjacent large channels in an interconnected format by selective masking and irreversible bonding.

  9. Neural mechanisms of timing control in a coincident timing task.

    PubMed

    Masaki, Hiroaki; Sommer, Werner; Takasawa, Noriyoshi; Yamazaki, Katuo

    2012-04-01

    Many ball sports such as tennis or baseball require precise temporal anticipation of both sensory input and motor output (i.e., receptor anticipation and effector anticipation, respectively) and close performance monitoring. We investigated the neural mechanisms underlying timing control and performance monitoring in a coincident timing task involving both types of anticipations. Peak force for two time-to-peak force (TTP) conditions-recorded with a force-sensitive key-was required to coincide with a specific position of a stimulus rotating either slow or fast on a clock face while the contingent negative variation (CNV) and the motor-elicited negativity were recorded. Absolute timing error was generally smaller for short TTP (high velocity) conditions. CNV amplitudes increased with both faster stimulus velocity and longer TTPs possibly reflecting increased motor programming efforts. In addition, the motor-elicited negativity was largest in the slow stimulus/short TTP condition, probably representing some forms of performance monitoring as well as shorter response duration. Our findings indicate that the coincident timing task is a good model for real-life situations of tool use.

  10. [Involuntary admission of addict during early pregnancy].

    PubMed

    Hondius, Adger J K; Stikker, Tineke E; Wennink, J M B Hanneke; Honig, Adriaan

    2012-01-01

    A 30-year-old cocaine-dependent woman was 16 weeks pregnant. Because of possible endangerment of the fetus, an involuntary provisional admission was authorized. Of particular interest is the application of the Dutch Act on Formal Admissions to Psychiatric Hospitals for the primary diagnosis 'addiction' and the fact that the fetus was regarded as a legal 'other'. In severe cases of addiction combined with pregnancy an earlier intervention is needed and arrangement of accelerated legal custody of the newborn before birth should be considered. For the protection of the unborn, we advocate a stricter application of the United Nations Convention on the Rights of the Child. Information for addicted women with preconception counselling can help prevent a compulsory admission. PMID:22258443

  11. Affirmative action policy in medical school admissions.

    PubMed

    Frazer, Ricardo A

    2005-02-01

    Legal challenges to affirmative action are growing, a trend suggesting that a proactive stance is needed to maintain a policy that still has viability, legitimacy, and utility. Medical schools admissions offices in the United States emphasize the Medical College Admissions Test (MCAT), even though many studies have found that grade point averages are better single predictors of future academic achievement, regardless of the student's socioeconomic or racial category. The current essay suggests there is an overreliance on the MCAT in medical school admissions. Medical colleges should encourage the development of additional applicant selection criteria, while continuing to use affirmative action programs, in part to address the need for increased community-oriented health care. PMID:15741705

  12. Mechanics and control of the cytoskeleton in Amoeba proteus.

    PubMed Central

    Dembo, M

    1989-01-01

    Many models of the cytoskeletal motility of Amoeba proteus can be formulated in terms of the theory of reactive interpenetrating flow (Dembo and Harlow, 1986). We have devised numerical methodology for testing such models against the phenomenon of steady axisymmetric fountain flow. The simplest workable scheme revealed by such tests (the minimal model) is the main preoccupation of this study. All parameters of the minimal model are determined from available data. Using these parameters the model quantitatively accounts for the self assembly of the cytoskeleton of A. proteus: for the formation and detailed morphology of the endoplasmic channel, the ectoplasmic tube, the uropod, the plasma gel sheet, and the hyaline cap. The model accounts for the kinematics of the cytoskeleton: the detailed velocity field of the forward flow of the endoplasm, the contraction of the ectoplasmic tube, and the inversion of the flow in the fountain zone. The model also gives a satisfactory account of measurements of pressure gradients, measurements of heat dissipation, and measurements of the output of useful work by amoeba. Finally, the model suggests a very promising (but still hypothetical) continuum formulation of the free boundary problem of amoeboid motion. by balancing normal forces on the plasma membrane as closely as possible, the minimal model is able to predict the turgor pressure and surface tension of A. proteus. Several dynamical factors are crucial to the success of the minimal model and are likely to be general features of cytoskeletal mechanics and control in amoeboid cells. These are: a constitutive law for the viscosity of the contractile network that includes an automatic process of gelation as the network density gets large; a very vigorous cycle of network polymerization and depolymerization (in the case of A. proteus, the time constant for this reaction is approximately 12 s); control of network contractility by a diffusible factor (probably calcium ion); and

  13. Mechanical Engineering Design Project report: Enabler control systems

    NASA Technical Reports Server (NTRS)

    Cullen, Christian; Delvecchio, Dave; Scarborough, Alan; Havics, Andrew A.

    1992-01-01

    The Controls Group was assigned the responsibility for designing the Enabler's control system. The requirement for the design was that the control system must provide a simple user interface to control the boom articulation joints, chassis articulation joints, and the wheel drive. The system required controlling hydraulic motors on the Enabler by implementing 8-bit microprocessor boards. In addition, feedback to evaluate positions and velocities must be interfaced to provide the operator with confirmation as well as control.

  14. Selection Methods for Undergraduate Admissions in Australia. Does the Australian Predominate Entry Scheme the Australian Tertiary Admissions Rank (ATAR) Have a Future?

    ERIC Educational Resources Information Center

    Blyth, Kathryn

    2014-01-01

    This article considers the Australian entry score system, the Australian Tertiary Admissions Rank (ATAR), and its usage as a selection mechanism for undergraduate places in Australian higher education institutions and asks whether its role as the main selection criterion will continue with the introduction of demand driven funding in 2012.…

  15. Mechanics, modulation and modelling: how muscles actuate and control movement

    PubMed Central

    Higham, Timothy E.; Biewener, Andrew A.; Delp, Scott L.

    2011-01-01

    Animal movement is often complex, unsteady and variable. The critical role of muscles in animal movement has captivated scientists for over 300 years. Despite this, emerging techniques and ideas are still shaping and advancing the field. For example, sonomicrometry and ultrasound techniques have enhanced our ability to quantify muscle length changes under in vivo conditions. Robotics and musculoskeletal models have benefited from improved computational tools and have enhanced our ability to understand muscle function in relation to movement by allowing one to simulate muscle–tendon dynamics under realistic conditions. The past decade, in particular, has seen a rapid advancement in technology and shifts in paradigms related to muscle function. In addition, there has been an increased focus on muscle function in relation to the complex locomotor behaviours, rather than relatively simple (and steady) behaviours. Thus, this Theme Issue will explore integrative aspects of muscle function in relation to diverse locomotor behaviours such as swimming, jumping, hopping, running, flying, moving over obstacles and transitioning between environments. Studies of walking and running have particular relevance to clinical aspects of human movement and sport. This Theme Issue includes contributions from scientists working on diverse taxa, ranging from humans to insects. In addition to contributions addressing locomotion in various taxa, several manuscripts will focus on recent advances in neuromuscular control and modulation during complex behaviours. Finally, some of the contributions address recent advances in biomechanical modelling and powered prostheses. We hope that our comprehensive and integrative Theme Issue will form the foundation for future work in the fields of neuromuscular mechanics and locomotion. PMID:21502117

  16. Electromagnetic energy coupling mechanism with matrix architecture control

    NASA Technical Reports Server (NTRS)

    Knowles, Gareth (Inventor); Hughes, Eli (Inventor)

    2006-01-01

    The present invention relates generally to reconfigurable, solid-state matrix arrays comprising multiple rows and columns of reconfigurable secondary mechanisms that are independently tuned. Specifically, the invention relates to reconfigurable devices comprising multiple, solid-state mechanisms characterized by at least one voltage-varied parameter disposed within a flexible, multi-laminate film, which are suitable for use as magnetic conductors, ground surfaces, antennas, varactors, ferrotunable substrates, or other active or passive electronic mechanisms.

  17. 44 CFR 19.220 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Admissions. 19.220 Section 19.220 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES...

  18. False confessions, expert testimony, and admissibility.

    PubMed

    Watson, Clarence; Weiss, Kenneth J; Pouncey, Claire

    2010-01-01

    The confession of a criminal defendant serves as a prosecutor's most compelling piece of evidence during trial. Courts must preserve a defendant's constitutional right to a fair trial while upholding the judicial interests of presenting competent and reliable evidence to the jury. When a defendant seeks to challenge the validity of that confession through expert testimony, the prosecution often contests the admissibility of the expert's opinion. Depending on the content and methodology of the expert's opinion, testimony addressing the phenomenon of false confessions may or may not be admissible. This article outlines the scientific and epistemological bases of expert testimony on false confession, notes the obstacles facing its admissibility, and provides guidance to the expert in formulating opinions that will reach the judge or jury. We review the 2006 New Jersey Superior Court decision in State of New Jersey v. George King to illustrate what is involved in the admissibility of false-confession testimony and use the case as a starting point in developing a best-practice approach to working in this area. PMID:20542936

  19. 49 CFR 25.300 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Admission. 25.300 Section 25.300 Transportation....310 apply, except as provided in §§ 25.225 and §§ 25.230. (b) Specific prohibitions. (1) In...) Subject to § 25.235(d), shall treat disabilities related to pregnancy, childbirth, termination...

  20. 49 CFR 25.300 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Admission. 25.300 Section 25.300 Transportation....310 apply, except as provided in §§ 25.225 and §§ 25.230. (b) Specific prohibitions. (1) In...) Subject to § 25.235(d), shall treat disabilities related to pregnancy, childbirth, termination...

  1. 49 CFR 25.300 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 1 2014-10-01 2014-10-01 false Admission. 25.300 Section 25.300 Transportation....310 apply, except as provided in §§ 25.225 and §§ 25.230. (b) Specific prohibitions. (1) In...) Subject to § 25.235(d), shall treat disabilities related to pregnancy, childbirth, termination...

  2. "Stealth Applicants" Are Changing the Admissions Equation

    ERIC Educational Resources Information Center

    Hoover, Eric

    2008-01-01

    Jeff Rickey is a numbers guy. But three years ago, a colleague asked him about something he'd never counted: applicants who came out of nowhere. The question intrigued Mr. Rickey, dean of admissions and financial aid at Earlham College in Indiana. He found that 17 percent of the college's applicants that year had not called, taken a tour, or…

  3. 43 CFR 4.1141 - Admissions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... request, or for the admission of the truth of any specified relevant matter of fact. (b) Each matter of... directed serves on the requesting party— (1) A sworn statement denying specifically the relevant matters of... matters involved are privileged or irrelevant or that the request is otherwise improper in whole or...

  4. 43 CFR 4.1141 - Admissions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... request, or for the admission of the truth of any specified relevant matter of fact. (b) Each matter of... directed serves on the requesting party— (1) A sworn statement denying specifically the relevant matters of... matters involved are privileged or irrelevant or that the request is otherwise improper in whole or...

  5. 17 CFR 12.33 - Admissions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... truth of any matters set forth in the request that relate to statements or opinions of fact or of the...) Reply. Each matter of which an admission is requested shall be separately set forth. The matter is... the matter. If objection is made, the reasons therefor shall be stated. The answer shall...

  6. 42 CFR 412.3 - Admissions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES General Provisions § 412.3 Admissions. (a) For... patient history and comorbidities, the severity of signs and symptoms, current medical needs, and the...

  7. 24 CFR 3.220 - Admissions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Admissions. 3.220 Section 3.220 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  8. 24 CFR 3.220 - Admissions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Admissions. 3.220 Section 3.220 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  9. 24 CFR 3.220 - Admissions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Admissions. 3.220 Section 3.220 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  10. 24 CFR 3.220 - Admissions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Admissions. 3.220 Section 3.220 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  11. 24 CFR 3.300 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Admission. 3.300 Section 3.300 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  12. 24 CFR 3.220 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Admissions. 3.220 Section 3.220 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  13. 24 CFR 3.300 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Admission. 3.300 Section 3.300 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  14. 24 CFR 3.300 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Admission. 3.300 Section 3.300 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  15. 24 CFR 3.300 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Admission. 3.300 Section 3.300 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL...

  16. 45 CFR 618.300 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Admission. 618.300 Section 618.300 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NONDISCRIMINATION ON THE BASIS... manner and under the same policies as any other temporary disability or physical condition; and (4)...

  17. 45 CFR 618.300 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Admission. 618.300 Section 618.300 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NONDISCRIMINATION ON THE BASIS... manner and under the same policies as any other temporary disability or physical condition; and (4)...

  18. University Admissions. Policy Note. Number 3

    ERIC Educational Resources Information Center

    Group of Eight (NJ1), 2012

    2012-01-01

    University admissions, like many other aspects of the higher education sector, are going through a time of significant change. From 2012, universities will receive full funding under the Commonwealth Grants Scheme (CGS) for as many places as they offer. Previously, the Government limited the number of funded places, with a tolerance band for…

  19. Foreign Language, the Classics, and College Admissions.

    ERIC Educational Resources Information Center

    LaFleur, Richard A.

    1993-01-01

    This article reports the results of a survey, funded by the American Classical League (ACL) and conducted during 1990-91, that assessed attitudes toward high school foreign-language study, in particular the study of Latin and Greek, in the college admissions process. (21 references) (VWL)

  20. The Admissions Criteria of Secondary Free Schools

    ERIC Educational Resources Information Center

    Morris, Rebecca

    2014-01-01

    This paper presents the results of an analysis of the admissions criteria used by the first two waves of secondary Free Schools in England. The type of criteria and their ranked order is explored and their potential impact on the school composition is considered. The findings demonstrate the diversity of criteria being used by this new type of…

  1. 32 CFR 575.2 - Admission; general.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... college or university; each candidate must obtain an official nomination to the Academy. The young person... admission are determined by performance on one of the regularly administered College Entrance Examination... December, January, March, and May at more than 700 College Board Test Centers throughout the United...

  2. 32 CFR 575.2 - Admission; general.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... college or university; each candidate must obtain an official nomination to the Academy. The young person... admission are determined by performance on one of the regularly administered College Entrance Examination... December, January, March, and May at more than 700 College Board Test Centers throughout the United...

  3. 32 CFR 575.2 - Admission; general.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... college or university; each candidate must obtain an official nomination to the Academy. The young person... admission are determined by performance on one of the regularly administered College Entrance Examination... December, January, March, and May at more than 700 College Board Test Centers throughout the United...

  4. 32 CFR 575.2 - Admission; general.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... college or university; each candidate must obtain an official nomination to the Academy. The young person... admission are determined by performance on one of the regularly administered College Entrance Examination... December, January, March, and May at more than 700 College Board Test Centers throughout the United...

  5. 45 CFR 86.15 - Admissions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Department of Health and Human Services GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN... recipient to which Subpart C applies shall not discriminate on the basis of sex in admission or recruitment... and continually from its establishment has had a policy of admitting only students of one sex....

  6. 45 CFR 86.15 - Admissions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN... recipient to which Subpart C applies shall not discriminate on the basis of sex in admission or recruitment... and continually from its establishment has had a policy of admitting only students of one sex....

  7. 45 CFR 86.15 - Admissions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN... recipient to which Subpart C applies shall not discriminate on the basis of sex in admission or recruitment... and continually from its establishment has had a policy of admitting only students of one sex....

  8. 45 CFR 86.15 - Admissions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN... recipient to which Subpart C applies shall not discriminate on the basis of sex in admission or recruitment... and continually from its establishment has had a policy of admitting only students of one sex....

  9. 45 CFR 86.15 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN... recipient to which Subpart C applies shall not discriminate on the basis of sex in admission or recruitment... and continually from its establishment has had a policy of admitting only students of one sex....

  10. 40 CFR 91.703 - Admission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... (a) A nonconforming marine SI engine offered for importation may only be imported into the United... admission shall not be granted unless the marine SI engine is exempted or excluded under § 91.704. (b) In... containing the following: (1) Identification of the importer of the marine SI engine and the...

  11. 34 CFR 106.15 - Admissions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE... students of one sex. (Authority: Secs. 901, 902, Education Amendments of 1972, 86 Stat. 373, 374; 20 U.S.C... 34 Education 1 2012-07-01 2012-07-01 false Admissions. 106.15 Section 106.15 Education...

  12. False confessions, expert testimony, and admissibility.

    PubMed

    Watson, Clarence; Weiss, Kenneth J; Pouncey, Claire

    2010-01-01

    The confession of a criminal defendant serves as a prosecutor's most compelling piece of evidence during trial. Courts must preserve a defendant's constitutional right to a fair trial while upholding the judicial interests of presenting competent and reliable evidence to the jury. When a defendant seeks to challenge the validity of that confession through expert testimony, the prosecution often contests the admissibility of the expert's opinion. Depending on the content and methodology of the expert's opinion, testimony addressing the phenomenon of false confessions may or may not be admissible. This article outlines the scientific and epistemological bases of expert testimony on false confession, notes the obstacles facing its admissibility, and provides guidance to the expert in formulating opinions that will reach the judge or jury. We review the 2006 New Jersey Superior Court decision in State of New Jersey v. George King to illustrate what is involved in the admissibility of false-confession testimony and use the case as a starting point in developing a best-practice approach to working in this area.

  13. 15 CFR 8a.220 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Admissions. 8a.220 Section 8a.220 Commerce and Foreign Trade Office of the Secretary of Commerce NONDISCRIMINATION ON THE BASIS OF SEX IN... institution. (c) Application of §§ 8a.300 through .310. Except as provided in paragraphs (d) and (e) of...

  14. 14 CFR 1253.300 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Admission. 1253.300 Section 1253.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of...

  15. 14 CFR 1253.300 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Admission. 1253.300 Section 1253.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of...

  16. 14 CFR § 1253.300 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Admission. § 1253.300 Section § 1253.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of...

  17. The National Center Test for University Admissions

    ERIC Educational Resources Information Center

    Watanabe, Yoshinori

    2013-01-01

    This article describes the National Center Test for University Admissions, a unified national test in Japan, which is taken by 500,000 students every year. It states that implementation of the Center Test began in 1990, with the English component consisting only of the written section until 2005, when the listening section was first implemented…

  18. 28 CFR 68.21 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Admissions. 68.21 Section 68.21 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RULES OF PRACTICE AND PROCEDURE FOR ADMINISTRATIVE HEARINGS BEFORE ADMINISTRATIVE LAW JUDGES IN CASES INVOLVING ALLEGATIONS OF UNLAWFUL EMPLOYMENT OF ALIENS,...

  19. 32 CFR 242.5 - Admission procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) MISCELLANEOUS ADMISSION POLICIES AND PROCEDURES FOR THE SCHOOL OF MEDICINE, UNIFORMED SERVICES UNIVERSITY OF THE... to the School of Medicine shall make direct application following instructions published in the... concerned or his designee prior to submitting formal application to the School of Medicine for...

  20. 32 CFR 242.5 - Admission procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) MISCELLANEOUS ADMISSION POLICIES AND PROCEDURES FOR THE SCHOOL OF MEDICINE, UNIFORMED SERVICES UNIVERSITY OF THE... to the School of Medicine shall make direct application following instructions published in the... concerned or his designee prior to submitting formal application to the School of Medicine for...

  1. 32 CFR 242.5 - Admission procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) MISCELLANEOUS ADMISSION POLICIES AND PROCEDURES FOR THE SCHOOL OF MEDICINE, UNIFORMED SERVICES UNIVERSITY OF THE... to the School of Medicine shall make direct application following instructions published in the... concerned or his designee prior to submitting formal application to the School of Medicine for...

  2. 32 CFR 242.5 - Admission procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) MISCELLANEOUS ADMISSION POLICIES AND PROCEDURES FOR THE SCHOOL OF MEDICINE, UNIFORMED SERVICES UNIVERSITY OF THE... to the School of Medicine shall make direct application following instructions published in the... concerned or his designee prior to submitting formal application to the School of Medicine for...

  3. Differential Prediction Generalization in College Admissions Testing

    ERIC Educational Resources Information Center

    Aguinis, Herman; Culpepper, Steven A.; Pierce, Charles A.

    2016-01-01

    We introduce the concept of "differential prediction generalization" in the context of college admissions testing. Specifically, we assess the extent to which predicted first-year college grade point average (GPA) based on high-school grade point average (HSGPA) and SAT scores depends on a student's ethnicity and gender and whether this…

  4. Rethinking the admission criteria to nursing school.

    PubMed

    Shulruf, Boaz; Wang, Ying Grace; Zhao, Yipin Jessica; Baker, Heather

    2011-11-01

    The main objective of this study was to identify the best predictors for student achievements (Undergraduate Grade Point Average (UGPA)) in their first year in an undergraduate nursing programme. Data were acquired from the Tracking Project database which is held by the Faculty of Medical and Health Sciences at the University of Auckland. The data (n=134) included information on student demographics, final year secondary school achievements (National Certificate of Educational Achievement Grade Point Average (NCEAGPA) & NCEA Credits), university admission ranking scores, and achievements in first year in the undergraduate nursing programme (UGPA). Linear regression models were used to identify the best predictors for first year students' UGPA in the nursing programme. The regression models suggest that the best predictor for the first year GPA is the NCEAGPA (beta=.488; R(2)(for the entire model)=.53), followed by the admission ranking scores (beta=.308; R(2)=.40). Based on these findings, it is suggested that a Dual Admission Model (DAM) be utilised whereby students could be admitted either by the current university admission criteria or by an alternative model, which is purely based on the predictability of achievement within the nursing programme. Application of the DAM to other institutions/countries was discussed.

  5. 7 CFR 502.2 - Admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Admission. 502.2 Section 502.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.2...

  6. 7 CFR 502.2 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 6 2013-01-01 2013-01-01 false Admission. 502.2 Section 502.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.2...

  7. 7 CFR 502.2 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 6 2014-01-01 2014-01-01 false Admission. 502.2 Section 502.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.2...

  8. 7 CFR 502.2 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false Admission. 502.2 Section 502.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.2...

  9. 7 CFR 502.2 - Admission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 6 2012-01-01 2012-01-01 false Admission. 502.2 Section 502.2 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE CONDUCT ON BELTSVILLE AGRICULTURE RESEARCH CENTER PROPERTY, BELTSVILLE, MARYLAND § 502.2...

  10. 45 CFR 618.300 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION NONDISCRIMINATION ON THE BASIS... for admission that has a disproportionately adverse effect on persons on the basis of sex unless the... effect are shown to be unavailable. (c) Prohibitions relating to marital or parental status....

  11. 16 CFR 3.32 - Admissions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the truth of any matters relevant to the pending proceeding set forth in the request that relate to... possession of the other party. Each matter of which an admission is requested shall be separately set forth. A copy of the request shall be filed with the Secretary. (b) The matter is admitted unless,...

  12. Similar Motor Cortical Control Mechanisms for Precise Limb Control during Reaching and Locomotion

    PubMed Central

    Yakovenko, Sergiy

    2015-01-01

    Throughout the course of evolution there has been a parallel development of the complexity and flexibility of the nervous system and the skeletomuscular system that it controls. This development is particularly evident for the cerebral cortical areas and the transformation of the use of the upper limbs from a purely locomotor function to one including, or restricted to, reaching and grasping. This study addresses the issue of whether the control of reaching has involved the development of new cortical circuits or whether the same neurons are used to control both locomotion and reaching. We recorded the activity of pyramidal tract neurons in the motor cortex of the cat both during voluntary gait modifications and during reaching. All cells showed generally similar patterns of activity in both tasks. More specifically, we showed that, in many cases, cells maintained a constant temporal relationship to the activity of synergistic muscle groups in each task. In addition, in some cells the relationship between the intensity of the cell discharge activity and the magnitude of the EMG activity was equally constant during gait modifications and reaching. As such, the results are compatible with the hypothesis that the corticospinal circuits used to control reaching evolved from those used to precisely modify gait. SIGNIFICANCE STATEMENT In an article in 1989, Georgopoulos and Grillner (1989) proposed that the corticospinal control mechanisms used for reaching movements in primates may have evolved from those used to control precise modifications of gait during quadrupedal locomotion. In this article, we provide a test of this hypothesis by recording the activity of individual motor cortical cells during both behaviors. Our results are compatible with the hypothesis in that they demonstrate that individual cortical neurons exhibit similar qualitative and quantitative patterns during each behavior. Beyond a general similarity of activity patterns, we show that some cortical

  13. Admission temperature and survival in patients admitted to burn centers.

    PubMed

    Hostler, David; Weaver, Matthew D; Ziembicki, Jenny A; Kowger, Heather L; McEntire, Serina J; Rittenberger, Jon C; Callaway, Clifton W; Patterson, P Daniel; Corcos, Alain C

    2013-01-01

    It is commonly believed that hypothermia occurring during burn resuscitation is associated with poor outcome, but there is little direct supporting evidence. The authors conducted an analysis of a statewide trauma registry to determine whether hypothermia (T ≤36.5°C) was associated with mortality when controlling for clinical confounders. They included all patients treated at an accredited burn center from 2000 to 2011 where the trauma registrar recorded the primary injury type as a burn. They excluded records with missing data and nonphysiologic temperature (<26°C or >42°C). The primary exposure of interest was hypothermia. The authors constructed a hierarchical, multivariable logistic regression model to examine the effect of hypothermia on survival, controlling for potentially confounding variables. Predictors of mortality are presented as odds ratio (95% confidence interval). Primary burn injury was coded 17,098 times during the study period. Of these, 3809 were not treated at a burn center and 1192 were excluded for missing data. Admission hypothermia was independently associated with mortality (1.91 [1.58-2.29]) when adjusting for age, sex, total second- and third-degree burn surface area (TBSA), comorbid conditions, injury severity score, direct transport vs referral, method of temperature measurement, year, and the hospital providing care. Increasing age, female sex, TBSA >40%, presence of multiple comorbid conditions, and increasing injury severity score were associated with mortality. Other variables in the model were not independently associated with outcome. There was a weak correlation between TBSA and admission temperature (r = .18). Hypothermia at hospital admission is independently associated with mortality in burn patients when controlling for clinical confounders. Future studies should address potential causes underlying this observation.

  14. Efficacy of Admission Screening for Extended-Spectrum Beta-Lactamase Producing Enterobacteriaceae

    PubMed Central

    Lowe, Christopher F.; Katz, Kevin; McGeer, Allison J.; Muller, Matthew P.

    2013-01-01

    Objective We hypothesized that admission screening for extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) reduces the incidence of hospital-acquired ESBL-E clinical isolates. Design Retrospective cohort study. Setting 12 hospitals (6 screening and 6 non-screening) in Toronto, Canada. Patients All adult inpatients with an ESBL-E positive culture collected from 2005–2009. Methods Cases were defined as hospital-onset (HO) or community-onset (CO) if cultures were positive after or before 72 hours. Efficacy of screening in reducing HO-ESBL-E incidence was assessed with a negative binomial model adjusting for study year and CO-ESBL-E incidence. The accuracy of the HO-ESBL-E definition was assessed by re-classifying HO-ESBL-E cases as confirmed nosocomial (negative admission screen), probable nosocomial (no admission screen) or not nosocomial (positive admission screen) using data from the screening hospitals. Results There were 2,088 ESBL-E positive patients and incidence of ESBL-E rose from 0.11 to 0.42 per 1,000 inpatient days between 2005 and 2009. CO-ESBL-E incidence was similar at screening and non-screening hospitals but screening hospitals had a lower incidence of HO-ESBL-E in all years. In the negative binomial model, screening was associated with a 49.1% reduction in HO-ESBL-E (p<0.001). A similar reduction was seen in the incidence of HO-ESBL-E bacteremia. When HO-ESBL-E cases were re-classified based on their admission screen result, 46.5% were positive on admission, 32.5% were confirmed as nosocomial and 21.0% were probable nosocomial cases. Conclusions Admission screening for ESBL-E is associated with a reduced incidence of HO-ESBL-E. Controlled, prospective studies of admission screening for ESBL-E should be a priority. PMID:23638132

  15. Passive dynamic controllers for non-linear mechanical systems

    NASA Technical Reports Server (NTRS)

    Juang, Jer-Nan; Wu, Shih-Chin; Phan, Minh; Longman, Richard W.

    1992-01-01

    The objective is to develop active model-independent controllers for slewing and vibration control of nonlinear multibody flexible systems, including flexible robots. The topics are presented in viewgraph form and include: passive stabilization; work-energy rate principle; Liapunov theory; displacement feedback; dynamic controller; displacement and acceleration feedback; velocity feedback; displacement feedback; physical interaction; a 6-DOF robot; and simulation results.

  16. Routine perineal shaving on admission in labour.

    PubMed

    Basevi, Vittorio; Lavender, Tina

    2014-01-01

    BackgroundPubic or perineal shaving is a procedure performed before birth in order to lessen the risk of infection if there is a spontaneous perinealtear or if an episiotomy is performed.ObjectivesTo assess the effects of routine perineal shaving before birth onmaternal and neonatal outcomes, according to the best available evidence.Search methodsWe searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (12 June 2014).Selection criteriaAll controlled trials (including quasi-randomised) that compare perineal shaving versus no perineal shaving.Data collection and analysisTwo review authors independently assessed all potential studies for inclusion, assessed risk of bias and extracted the data using apredesigned form. Data were checked for accuracy.Main resultsThree randomised controlled trials (1039 women) published between 1922 and 2005 fulfilled the prespecified criteria. In the earliesttrial, 389 women were alternately allocated to receive either skin preparation and perineal shaving or clipping of vulval hair only. In thesecond trial, which included 150 participants, perineal shaving was compared with the cutting of long hairs for procedures only. In thethird and most recent trial, 500 women were randomly allocated to shaving of perineal area or cutting of perineal hair. The primaryoutcome for all three trials was maternal febrile morbidity; no differences were found (risk ratio (RR) 1.14, 95% confidence interval(CI) 0.73 to 1.76). No differences were found in terms of perineal wound infection (RR 1.47, 95% CI 0.80 to 2.70) and perinealwound dehiscence (RR 0.33, 95% CI 0.01 to 8.00) in the most recent trial involving 500 women, which was the only trial to assessthese outcomes. In the smallest trial, fewer women who had not been shaved had Gram-negative bacterial colonisation compared withwomen who had been shaved (RR 0.83, 95% CI 0.70 to 0.98). There were no instances of neonatal infection in either group in theone trial that reported this

  17. Air pollution and emergency hospital admissions for cardiovascular diseases in Valencia, Spain

    PubMed Central

    Ballester, F; Tenias, J; Perez-Hoyos, S

    2001-01-01

    STUDY OBJECTIVE—To estimate the short-term association between air pollution levels and emergency hospital admissions for cardiovascular diseases in Valencia, within 1994-1996 period.
DESIGN—Daily levels of air pollution and emergency admissions for cardiovascular diseases were related to using an ecological time series design. The number of admissions was obtained from the hospital records database. Selected groups of causes were all cardiovascular diseases, heart admissions, and admissions for cerebrovascular diseases. The number of admissions for digestive diseases was used as control. Pollutants were black smoke, sulphur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO) and ozone (O3). Magnitude of association was estimated by Poisson autoregresive regression. Estimations were calculated according the hottest (May to October) and the coldest (November to April) periods.
SETTING—City of Valencia, Spain, about 750 000 inhabitants.
PARTICIPANTS—People being admitted to the two major hospitals in the city, with a catchment area of nearly 400 000 inhabitants.
MAIN RESULTS—For the whole period, a significant association for SO2-24 h was found so a rise in its levels of 10 µg/m3 was associated with an increment of 3% (95%CI 0.4 to 5.7%) in the expected number of cardiovascular admissions. A significant association for black smoke, SO2-24 h, SO2-1 h, and CO-1 h was found in the hottest semester. All these associations were verified with a lag of two days. The estimates of the associations for particles, SO2, and CO were affected by the inclusion of the other pollutants in their models. NO2 was independently associated with cerebrovascular admissions. There were no significant associations between air pollution and admissions for digestive diseases.
CONCLUSIONS—Current levels of air pollution and emergency cardiovascular admissions are significantly related in Valencia.


Keywords: air pollution; cardiovascular disease

  18. Mechanical Control of the Sense of Touch by β Spectrin

    PubMed Central

    Krieg, Michael; Dunn, Alexander R.; Goodman, Miriam B.

    2014-01-01

    The ability to sense and respond to mechanical stimuli emanates from sensory neurons and is shared by most, if not all animals. Exactly how such neurons receive and distribute mechanical signals during touch sensation remains mysterious. Here, we show that sensation of mechanical forces depends on a continuous, pre-stressed spectrin cytoskeleton inside neurons. Mutations in the tetramerization domain of C. elegans β-spectrin (UNC-70), an actin-membrane cross-linker, cause defects in sensory neuron morphology under compressive stress in moving animals. Through AFM force spectroscopy experiments on isolated neurons, in vivo laser axotomy and FRET imaging to measure force across single cells and molecules, we show that spectrin is held under constitutive tension in living animals, which contributes to an elevated pre-stress in touch receptor neurons. Genetic manipulations that decrease such spectrin-dependent tension also selectively impair touch sensation, suggesting that such pretension is essential for efficient responses to external mechanical stimuli. PMID:24561618

  19. Independent backup mode transfer and mechanism for digital control computers

    NASA Technical Reports Server (NTRS)

    Tulpule, Bhalchandra R. (Inventor); Oscarson, Edward M. (Inventor)

    1992-01-01

    An interrupt is provided to a signal processor having a non-maskable interrupt input, in response to the detection of a request for transfer to backup software. The signal processor provides a transfer signal to a transfer mechanism only after completion of the present machine cycle. Transfer to the backup software is initiated by the transfer mechanism only upon reception of the transfer signal.

  20. SPRING DRIVEN ACTUATING MECHANISM FOR NUCLEAR REACTOR CONTROL

    DOEpatents

    Bevilacqua, F.; Uecker, D.F.; Groh, E.F.

    1962-01-23

    l962. rod in a nuclear reactor to shut it down. The control rod or an extension thereof is wound on a drum as it is withdrawn from the reactor. When an emergency occurs requiring the reactor to be shut down, the drum is released so as to be free to rotate, and the tendency of the control rod or its extension coiled on the drum to straighten itself is used for quickly returning the control rod to the reactor. (AEC)

  1. New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

    PubMed Central

    Liu, Tong; Ji, Ru-Rong

    2013-01-01

    Itch and pain are closely related but distinct sensations. They share largely overlapping mediators and receptors, and itch-responding neurons are also sensitive to pain stimuli. Itch-mediating primary sensory neurons are equipped with distinct receptors and ion channels for itch transduction, including Mas-related G protein-coupled receptors (Mrgprs), protease-activated receptors (PARs), histamine receptors, bile acid receptor (TGR5), toll-like receptors (TLRs), and transient receptor potential subfamily V1/A1 (TRPV1/A1). Recent progress has indicated the existence of an itch-specific neuronal circuitry. The MrgprA3-expressing primary sensory neurons exclusively innervate the epidermis of skin and their central axons connect with gastrin-releasing peptide receptor (GRPR)-expressing neurons in the superficial spinal cord. Notably, ablation of MrgprA3-expressing primary sensory neurons or GRPR-expressing spinal cord neurons results in selective reduction in itch but not pain. Chronic itch results from dysfunction of the immune and nervous system and can manifest as neural plasticity, despite the fact that chronic itch is often treated by dermatologists. While differences between acute pain and acute itch are striking, chronic itch and chronic pain share many similar mechanisms, including peripheral sensitization (increased responses of primary sensory neurons to itch and pain mediators), central sensitization (hyperactivity of spinal projection neurons and excitatory interneurons), loss of inhibitory control in the spinal cord, and neuro-immune and neuro-glial interactions. Notably, painful stimuli can elicit itch in some chronic conditions (e.g., atopic dermatitis) and some drugs for treating chronic pain are also effective in chronic itch. Thus, itch and pain have more similarities in pathological and chronic conditions. PMID:23636773

  2. 33 CFR 20.1311 - Admissions by respondent.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Supplementary Evidentiary Rules for Suspension and Revocation Hearings § 20.1311 Admissions by respondent. No person may testify regarding admissions made by the respondent during an investigation under 46 CFR...

  3. 49 CFR 386.44 - Request for admissions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... presents an issue of fact for hearing. (b) Effect of admission. Any matter admitted is conclusively... later proved, the party requesting the admission may move for an award of expenses incurred in...

  4. 16 CFR 1025.34 - Requests for admission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... admission may move to determine the sufficiency of any answer or objection in accordance with § 1025.36 of.... (c) Effect of admission. Any matter admitted under this section is conclusively established...

  5. 49 CFR 511.34 - Requests for admission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... admission may move to determine the sufficiency of the answer or objection thereto in accordance with § 511...) Effect of admission. Any matter admitted under this section is conclusively established unless...

  6. Pheromonal control: reconciling physiological mechanism with signalling theory.

    PubMed

    Peso, Marianne; Elgar, Mark A; Barron, Andrew B

    2015-05-01

    Pheromones are intraspecific chemical signals. They can have profound effects on the behaviour and/or physiology of the receiver, and it is still common to hear pheromones described as controlling of the behaviour of the receiver. The discussion of pheromonal control arose initially from a close association between hormones and pheromones in the comparative physiological literature, but the concept of a controlling pheromone is at odds with contemporary signal evolution theory, which predicts that a manipulative pheromonal signal negatively affecting the receiver's fitness should not be stable over evolutionary time. Here we discuss the meaning of pheromonal control, and the ecological circumstances by which it might be supported. We argue that in discussing pheromonal control it is important to differentiate between control applied to the effects of a pheromone on a receiver's physiology (proximate control), and control applied to the effects of a pheromone on a receiver's fitness (ultimate control). Critically, a pheromone signal affecting change in the receiver's behaviour or physiology need not necessarily manipulate the fitness of a receiver. In cases where pheromonal signalling does lead to a reduction in the fitness of the receiver, the signalling system would be stable if the pheromone were an honest signal of a social environment that disadvantages the receiver, and the physiological and behavioural changes observed in the receiver were an adaptive response to the new social circumstances communicated by the pheromone. PMID:24925630

  7. Mechanisms of Molecular Response in the Optimal Control of Photoisomerization

    SciTech Connect

    Dietzek, Benjamin; Brueggemann, Ben; Pascher, Torbjoern; Yartsev, Arkady

    2006-12-22

    We report on adaptive feedback control of photoinduced barrierless isomerization of 1,1'-diethyl-2,2'-cyanine in solution. We compare the effect of different fitness parameters and show that optimal control of the absolute yield of isomerization (photoisomer concentration versus excitation photons) can be achieved, while the relative isomerization yield (photoisomer concentration versus number of relaxed excited-state molecules) is unaffected by adaptive feedback control. The temporal structure of the optimized excitation pulses allows one to draw clear mechanistic conclusions showing the critical importance of coherent nuclear motion for the control of isomerization.

  8. Coarse Particulate Air Pollution Associated with Increased Risk of Hospital Admissions for Respiratory Diseases in a Tropical City, Kaohsiung, Taiwan

    PubMed Central

    Cheng, Meng-Hsuan; Chiu, Hui-Fen; Yang, Chun-Yuh

    2015-01-01

    This study was undertaken to determine whether there was an association between coarse particles (PM2.5–10) levels and frequency of hospital admissions for respiratory diseases (RD) in Kaohsiung, Taiwan. Hospital admissions for RD including chronic obstructive pulmonary disease (COPD), asthma, and pneumonia, and ambient air pollution data levels for Kaohsiung were obtained for the period from 2006 to 2010. The relative risk of hospital admissions for RD was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. For the single pollutant model (without adjustment for other pollutants), increased rate of admissions for RD were significantly associated with higher coarse PM levels only on cool days (<25 °C), with a 10 µg/m3 elevation in PM2.5–10 concentrations associated with a 3% (95% CI = 1%–5%) rise in COPD admissions, 4% (95% CI = 1%–7%) increase in asthma admissions, and 3% (95% CI = 2%–4%) rise in pneumonia admissions. No significant associations were found between coarse particle levels and the number of hospital admissions for RD on warm days. In the two-pollutant models, PM2.5–10 levels remained significantly correlated with higher rate of RD admissions even controlling for sulfur dioxide, nitrogen dioxide, carbon monoxide, or ozone on cool days. This study provides evidence that higher levels of PM2.5–10 enhance the risk of hospital admissions for RD on cool days. PMID:26501308

  9. 42 CFR 456.171 - Medicaid agency review of need for admission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Medicaid agency review of need for admission. 456.171 Section 456.171 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control:...

  10. 42 CFR 456.171 - Medicaid agency review of need for admission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Medicaid agency review of need for admission. 456.171 Section 456.171 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control:...

  11. 42 CFR 456.171 - Medicaid agency review of need for admission.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Medicaid agency review of need for admission. 456.171 Section 456.171 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control:...

  12. 42 CFR 456.171 - Medicaid agency review of need for admission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Medicaid agency review of need for admission. 456.171 Section 456.171 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control:...

  13. 42 CFR 456.171 - Medicaid agency review of need for admission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Medicaid agency review of need for admission. 456.171 Section 456.171 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS UTILIZATION CONTROL Utilization Control:...

  14. CONTROL ROD DRIVE MECHANISM FOR A NUCLEAR REACTOR

    DOEpatents

    Hawke, B.C.; Liederbach, F.J.; Lones, W.

    1963-05-14

    A lead-screw-type control rod drive featuring an electric motor and a fluid motor arranged to provide a selectably alternative driving means is described. The electric motor serves to drive the control rod slowly during normal operation, while the fluid motor, assisted by an automatic declutching of the electric motor, affords high-speed rod insertion during a scram. (AEC)

  15. Correction: β-Sialon nanowires, nanobelts and hierarchical nanostructures: morphology control, growth mechanism and cathodoluminescence properties

    NASA Astrophysics Data System (ADS)

    Huang, Juntong; Huang, Zhaohui; Liu, Yangai; Fang, Minghao; Chen, Kai; Huang, Yaoting; Huang, Saifang; Ji, Haipeng; Yang, Jingzhou; Wu, Xiaowen; Zhang, Shaowei

    2016-07-01

    Correction for `β-Sialon nanowires, nanobelts and hierarchical nanostructures: morphology control, growth mechanism and cathodoluminescence properties' by Juntong Huang, et al., Nanoscale, 2014, 6, 424-432.

  16. Molecular control of myocardial mechanics and energetics: the chemo-mechanical conversion.

    PubMed

    Landesberg, A

    1997-01-01

    Energy consumption in the cardiac muscle is characterized by two basic phenomena: 1) The well known linear relationship between energy consumption by the sarcomere and the mechanical energy it generates, and 2) the ability to modulate the generated mechanical energy and energy consumption to the various loading conditions, as is manifested by the Frank-Starling Law and the Fenn effect. These basic phenomena are analyzed here based on coupling calcium kinetics with crossbridge (Xb) cycling. Our previous studies established the existence of two feedback mechanism: 1) a positive feedback mechanism, the cooperativity, whereby the affinity of the troponin for calcium, and hence Xb and actomyosin-ATPase recruitment, depends on the number of force generating Xbs, and 2) a mechanical feedback, whereby the filaments shortening velocity, or the Xb strain rate, determines the rate of Xb turnover from the strong to the weak conformation. The cooperativity mechanism determines the force-length relationship (FLR) and the related Frank-Starling Law. It also provides the basis for the regulation of energy consumption and the ability of the muscle to adapt its energy consumption to the loading conditions. The mechanical feedback regulates the shortening velocity and provides the analytical solution for the experimentally derived Hill's equation for the force-velocity relationship (FVR). The mechanical feedback regulates the generated power and provides the linear relationship between energy consumption and the generated mechanical energy, i.e., the external work done and the liberated heat. Thus, the two feedback mechanisms that regulate sarcomere dynamics, and determine the FLR and FVR, also regulate the energy consumption and the mechanical energy generated by the muscle.

  17. Mechanisms Involved in Nematode Control by Endophytic Fungi.

    PubMed

    Schouten, Alexander

    2016-08-01

    Colonization of plants by particular endophytic fungi can provide plants with improved defenses toward nematodes. Evidently, such endophytes can be important in developing more sustainable agricultural practices. The mechanisms playing a role in this quantitative antagonism are poorly understood but most likely multifactorial. This knowledge gap obstructs the progress regarding the development of endophytes or endophyte-derived constituents into biocontrol agents. In part, this may be caused by the fact that endophytic fungi form a rather heterogeneous group. By combining the knowledge of the currently characterized antagonistic endophytic fungi and their effects on nematode behavior and biology with the knowledge of microbial competition and induced plant defenses, the various mechanisms by which this nematode antagonism operates or may operate are discussed. Now that new technologies are becoming available and more accessible, the currently unresolved mechanisms can be studied in greater detail than ever before. PMID:27296146

  18. Mechanisms Involved in Nematode Control by Endophytic Fungi.

    PubMed

    Schouten, Alexander

    2016-08-01

    Colonization of plants by particular endophytic fungi can provide plants with improved defenses toward nematodes. Evidently, such endophytes can be important in developing more sustainable agricultural practices. The mechanisms playing a role in this quantitative antagonism are poorly understood but most likely multifactorial. This knowledge gap obstructs the progress regarding the development of endophytes or endophyte-derived constituents into biocontrol agents. In part, this may be caused by the fact that endophytic fungi form a rather heterogeneous group. By combining the knowledge of the currently characterized antagonistic endophytic fungi and their effects on nematode behavior and biology with the knowledge of microbial competition and induced plant defenses, the various mechanisms by which this nematode antagonism operates or may operate are discussed. Now that new technologies are becoming available and more accessible, the currently unresolved mechanisms can be studied in greater detail than ever before.

  19. 42 CFR 456.123 - Admission review process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Admission review process. 456.123 Section 456.123 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Need for Admission 1 § 456.123 Admission review process. The UR plan must provide that— (a)...

  20. 42 CFR 456.123 - Admission review process.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Admission review process. 456.123 Section 456.123 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Need for Admission 1 § 456.123 Admission review process. The UR plan must provide that— (a)...

  1. 49 CFR 1114.3 - Admissibility of business records.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Admissibility of business records. 1114.3 Section... § 1114.3 Admissibility of business records. Any writing or record, whether in the form of an entry in a... be admissible as evidence thereof if it appears that it was made in the regular course of...

  2. 49 CFR 511.34 - Requests for admission.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... for the admission, for the purposes of the pending proceeding only, of the truth of any matters within... served upon any party after filing of the answer. Each matter as to which an admission is requested shall be separately set forth. (b) Procedure for response. The matter as to which an admission is...

  3. 49 CFR 511.34 - Requests for admission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... for the admission, for the purposes of the pending proceeding only, of the truth of any matters within... served upon any party after filing of the answer. Each matter as to which an admission is requested shall be separately set forth. (b) Procedure for response. The matter as to which an admission is...

  4. Equity of Access. New Approaches to Minority Admissions

    ERIC Educational Resources Information Center

    Bingham, Rebecca Saady

    1978-01-01

    One new approach to the admission of minorities to medical schools is that of the Simulated Minority Admission Exercises (SMAE). It sensitizes admission committee members to the different backgrounds of minority applicants and teaches them to evaluate them more effectively. (Author/AM)

  5. Pursuing Equity in and through Teacher Education Program Admissions

    ERIC Educational Resources Information Center

    Childs, Ruth A.; Broad, Kathryn; Gallagher-Mackay, Kelly; Sher, Yael; Escayg, Kerry-Ann; McGrath, Christopher

    2011-01-01

    This case study investigated equity in teacher education admissions. Through document analysis and structured interviews with ten past or current members of the admissions committee in a large initial teacher education program in Ontario, we developed an understanding of equity in teacher education admissions as encompassing two foci: equity in…

  6. 49 CFR 1114.3 - Admissibility of business records.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Admissibility of business records. 1114.3 Section... § 1114.3 Admissibility of business records. Any writing or record, whether in the form of an entry in a... be admissible as evidence thereof if it appears that it was made in the regular course of...

  7. 49 CFR 1114.3 - Admissibility of business records.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Admissibility of business records. 1114.3 Section... § 1114.3 Admissibility of business records. Any writing or record, whether in the form of an entry in a... be admissible as evidence thereof if it appears that it was made in the regular course of...

  8. Behind the Scenes, Admissions Offices Conquer Mounds of Mail

    ERIC Educational Resources Information Center

    Farrell, Elizabeth F.

    2008-01-01

    If coming back to work after winter break seems daunting, consider the plight of college-admissions officials. While most high-school students are breathing a sigh of relief after finally submitting their applications, those on the receiving end are rolling up their sleeves. January is crunch time for many admissions offices. Admissions officers…

  9. The Roles of Testing and Diversity in College Admissions.

    ERIC Educational Resources Information Center

    Clarke, Marguerite; Shore, Arnold

    In order to understand the roles of test scores and diversity characteristics (including race and ethnicity) in the admission process, National Board researchers interviewed admissions directors who worked at selective public and private institutions are well as admissions consultants in the summer and fall of 1999. This report presents an…

  10. 45 CFR 618.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Preference in admission. 618.305 Section 618.305... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 618.305 Preference in admission. A recipient to which §§ 618.300 through 618.310 apply shall not give preference to applicants for...

  11. 13 CFR 113.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Preference in admission. 113.305... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 113.305 Preference in admission. A recipient to which §§ 113.300 through 113.310 apply shall not give preference to applicants for...

  12. 10 CFR 5.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Preference in admission. 5.305 Section 5.305 Energy... Prohibited § 5.305 Preference in admission. A recipient to which §§ 5.300 through 5.310 apply shall not give preference to applicants for admission, on the basis of attendance at any educational institution or...

  13. 18 CFR 1317.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Preference in admission... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 1317.305 Preference in admission. A recipient to which §§ 1317.300 through 1317.310 apply shall not give preference to applicants for...

  14. 29 CFR 36.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Preference in admission. 36.305 Section 36.305 Labor Office... Prohibited § 36.305 Preference in admission. A recipient to which §§ 36.300 through 36.310 apply shall not give preference to applicants for admission, on the basis of attendance at any educational...

  15. 7 CFR 15a.22 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Preference in admission. 15a.22 Section 15a.22... Prohibited § 15a.22 Preference in admission. A recipient to which the subpart applies shall not give preference to applicants for admission, on the basis of attendance at any educational institution or...

  16. 44 CFR 19.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Preference in admission. 19... Recruitment Prohibited § 19.305 Preference in admission. A recipient to which §§ 19.300 through 19.310 apply shall not give preference to applicants for admission, on the basis of attendance at any...

  17. 10 CFR 1042.305 - Preference in admission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Preference in admission. 1042.305 Section 1042.305 Energy... Recruitment Prohibited § 1042.305 Preference in admission. A recipient to which §§ 1042.300 through 1042.310 apply shall not give preference to applicants for admission, on the basis of attendance at...

  18. 7 CFR 15b.30 - Admissions and recruitment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Admissions and recruitment. 15b.30 Section 15b.30... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Postsecondary Education § 15b.30 Admissions and recruitment... be subjected to discrimination in admission or recruitment by a recipient to which this...

  19. 38 CFR 18.442 - Admissions and recruitment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... recruitment. 18.442 Section 18.442 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS... Postsecondary Education § 18.442 Admissions and recruitment. (a) General. Qualified handicapped persons may not... recruitment by a recipient. (b) Admission. In administering its admission policies, a recipient; (1) May...

  20. Applications Quest: A Case Study on Holistic Diversity in Admission

    ERIC Educational Resources Information Center

    Gilbert, Juan

    2008-01-01

    After the 2003 U.S. Supreme Court decisions on the University of Michigan admission cases, which struck down racial preferences and quotas in Michigan's undergraduate and law school admission, several groups have challenged race-conscious admission, school placement policies and academic support programs. Even the federal government has challenged…

  1. Oestrogen Modulates Hypothalamic Control of Energy Homeostasis Through Multiple Mechanisms

    PubMed Central

    Roepke, Troy A.

    2009-01-01

    The control of energy homeostasis in women is correlated with the anorectic effects of oestrogen, which can attenuate body weight gain and reduce food intake in rodent models. This review will investigate the multiple signalling pathways and cellular targets that oestrogen utilises to control energy homeostasis in the hypothalamus. Oestrogen affects all of the hypothalamic nuclei that control energy homeostasis. Oestrogen controls the activity of hypothalamic neurones through gene regulation and neuronal excitability. Oestrogen’s primary cellular pathway is the control of gene transcription through the classical ERs (ERα and ERβ) with ERα having the primary role in energy homeostasis. Oestrogen also controls energy homeostasis through membrane-mediated events via membrane-associated ERs or a novel, putative membrane ER that is coupled to G-proteins. Therefore, oestrogen has at least two receptors with multiple signalling and transcriptional pathways to activate during immediate and long-term anorectic effects. Ultimately, it is the interactions of all the receptor-mediated processes in hypothalamus and other areas of the CNS that will determine the anorectic effects of oestrogen and its control of energy homeostasis. PMID:19076267

  2. Multiplicity of mechanisms govern efficacy of anaerobic soil disinfestation for soil-borne disease control

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Studies demonstrated that carbon input type influenced control of various fungi, oomycetes and plant parasitic nematodes with anaerobic soil disinfestation (ASD). Findings implicated multiple mechanisms may contribute to the overall level of disease control attained. In strawberry field trials, ASD ...

  3. Emergency department census of patients awaiting admission following reorganisation of an admissions process

    PubMed Central

    Moloney, E D; Bennett, K; O'Riordan, D; Silke, B

    2006-01-01

    Objectives To determine the impact of reorganisation of an acute admissions process on numbers of people in the emergency department (ED) awaiting admission to a hospital bed in a major teaching hospital. Methods We studied all emergency medical patients admitted to St James' Hospital, Dublin, between 1 January 2002 and 31 December 2004. In 2002, patients were admitted to a variety of wards from the ED when a hospital bed became available. In 2003, two centrally located wards were reconfigured to function as an acute medical admissions unit (AMAU) (bed capacity 59), and all emergency patients were admitted directly to this unit from the ED (average 15 admissions per day). The maximum permitted length of stay on the AMAU was 5 days. We recorded the number of patients in the ED, who were awaiting the availability of a hospital bed, at 0700 and 1700 on the days of recording during the 36 month study period. Results The impact of the AMAU reduced overall hospital length of stay from 7 days in 2002 to 5 days in 2003 and 2004 (p<0.0001). The median number of patients waiting in the ED for a hospital bed reduced from 14 in 2002 to 9 in 2003 and 8 in 2004 (p<0.0001). While age and sex of patients did not differ over the years, the factors that independently contributed to the number of patients awaiting admission were the day of the week, the month of the year, and and the extent of the comorbidity index on the previous day's intake (p<0.0001). Conclusions This study found that reorganisation of a system for acute medical admissions can significantly impact on the number of patients awaiting admission to a hospital bed, and allow an ED to operate efficiently and at a level of risk acceptable to patients. PMID:16627837

  4. Quantum and classical control of single photon states via a mechanical resonator

    NASA Astrophysics Data System (ADS)

    Basiri-Esfahani, Sahar; Myers, Casey R.; Combes, Joshua; Milburn, G. J.

    2016-06-01

    Optomechanical systems typically use light to control the quantum state of a mechanical resonator. In this paper, we propose a scheme for controlling the quantum state of light using the mechanical degree of freedom as a controlled beam splitter. Preparing the mechanical resonator in non-classical states enables an optomechanical Stern-Gerlach interferometer. When the mechanical resonator has a small coherent amplitude it acts as a quantum control, entangling the optical and mechanical degrees of freedom. As the coherent amplitude of the resonator increases, we recover single photon and two-photon interference via a classically controlled beam splitter. The visibility of the two-photon interference is particularly sensitive to coherent excitations in the mechanical resonator and this could form the basis of an optically transduced weak-force sensor.

  5. The role of the asthma nurse in treatment compliance and self-management following hospital admission.

    PubMed

    Morice, A H; Wrench, C

    2001-11-01

    Effective self-management and treatment compliance is important in achieving good symptom control in asthma. The aim of this study was to determine whether asthma nurse intervention during hospital admission could increase knowledge and improve self-management and whether this would influence the number of emergency call-out visits by Genera Practitioners (GPs) and hospital re-admissions. Patients with acute asthma (n=80) were assessed by the asthma nurse within 24 h of admission using a British Thoracic Society (BTS) guideline-based questionnaire. Main outcome measures were: know edge of inhalers, self-management plans, peak flow monitoring, recognition of worsening symptoms and appropriate emergency action, Following randomization, half received nurse intervention during hospitalization. All received a follow-up questionnaire 6 weeks post-discharge and again at 6 months (response rates 86% and 81% respectively). GPs were contacted by postal questionnaire after 4 months. Questionnaire responses indicated an increase in knowledge in the intervention group, along with an ability to identify appropriate action on worsening symptoms. Emergency GP call-outs were more frequent in the control group in the 4 months post-discharge. Hospital re-admission rates were similar in both groups. Asthma nurse intervention appeared to increase knowledge of asthma management, maintained throughout the study period, but had no significant impact on reducing re-admissions to hospital.

  6. A Role for Marketing in College Admissions. Papers Presented at the Colloquium on College Admissions, May 16-l8, 1976.

    ERIC Educational Resources Information Center

    College Entrance Examination Board, New York, NY.

    This collection stresses the need for informed and more sophisticated marketing techniques for college admissions officers to help them cope with the decreasing number of prospective college students. The importance of the college admissions office is increasing as admissions becomes a more crucial element to the colleges' financial well-being.…

  7. Complexity in College Admission: Fact or Urban Myth. Research Findings of Parent and Student Perceptions of Complexity in College Admission

    ERIC Educational Resources Information Center

    College Board Advocacy & Policy Center, 2010

    2010-01-01

    In September 2007, the College Board formed the Task Force on Admissions in the 21st Century in response to a request from the Guidance and Admission Assembly Council (GAA Council) to more closely examine the high-school-to-college transition process. Each spring, at the conclusion of the college admission cycle, there is much discussion in the…

  8. Flemion-based actuator for mechanically controlled microwave switch

    NASA Astrophysics Data System (ADS)

    Le Guilly, Marie; Xu, Chunye; Cheng, Victor; Taya, Minoru; Opperman, Lucien; Kuga, Yasuo

    2003-07-01

    A microwave switch based on EAP presents several advantages. A switch based on Flemion is studied. Flemion a perfluorinated carboxylic acid membrane shows improved performance as actuator material compared with Nafion (perfluorinated sulfonic acid). Flemion has a higher ion exchange capacity and good mechanical strength. In order to get a good Flemion actuator, highly conductive soft gold electrodes with large fractal structure have to be deposited on the membrane. The impregnation reduction technique used for plating requires exchange of a gold complex and reduction by gradual sodium sulfite additions. K+ shows the highest exchange ratio with the gold complex and reducing bath temperatures around 60°C with enough reducing agent present are shown to promote the growth of a gold fractal structure. The resulting material shows an actuation displacement with no relaxation, a key feature for switch applications. A simple mechanical switch based on a flemion actuator is prepared and tested as a microwave switch.

  9. Biomolecular Mechanisms Controlling Metal and Radionuclide Transformations in Anaeromyxobacter dehalogenans

    SciTech Connect

    Beliaev, Alexander S.; Fredrickson, James K.; Loeffler, Frank E.; Sanford, Robert A.

    2006-06-01

    Microbiological reduction and immobilization of U(VI) and Tc(VII) has been proposed as a strategy for remediating radionuclide-contaminated environments. Numerous studies focusing on the reduction kinetics and speciation of these metals have been carried out using contaminated sediment samples, microbial consortia, and pure bacterial cultures. While previous work with model organisms has increased the general understanding of radionuclide transformation processes, fundamental questions regarding radionuclide reduction mechanisms by indigenous microorganisms are poorly understood, especially under the commonly encountered scenario where multiple electron acceptors are present. Therefore, the overall goal of the proposed research is to elucidate the molecular mechanisms of radionuclide biotransformation by Anaeromyxobacter dehalogenans, a predominant member of indigenous microorganism commonly found in contaminated subsurface environments, and to assess the effects of relevant environmental factors affecting these transformation reactions.

  10. Chromatin mechanisms in the developmental control of imprinted gene expression.

    PubMed

    Sanli, Ildem; Feil, Robert

    2015-10-01

    Hundreds of protein-coding genes and regulatory non-coding RNAs (ncRNAs) are subject to genomic imprinting. The mono-allelic DNA methylation marks that control imprinted gene expression are somatically maintained throughout development, and this process is linked to specific chromatin features. Yet, at many imprinted genes, the mono-allelic expression is lineage or tissue-specific. Recent studies provide mechanistic insights into the developmentally-restricted action of the 'imprinting control regions' (ICRs). At several imprinted domains, the ICR expresses a long ncRNA that mediates chromatin repression in cis (and probably in trans as well). ICRs at other imprinted domains mediate higher-order chromatin structuration that enhances, or prevents, transcription of close-by genes. Here, we present how chromatin and ncRNAs contribute to developmental control of imprinted gene expression and discuss implications for disease. This article is part of a Directed Issue entitled: Epigenetics dynamics in development and disease.

  11. Neural mechanisms of impulse control in sexually risky adolescents

    PubMed Central

    Goldenberg, Diane; Telzer, Eva H.; Lieberman, Matthew D.; Fuligni, Andrew; Galván, Adriana

    2014-01-01

    The consequences of risky sexual behavior are of public concern. Adolescents contribute disproportionately to negative consequences of risky sexual behavior. However, no research has examined the neural correlates of impulse control and real-world engagement in risky sexual behavior in this population. The aim of the present study was to examine this question. Twenty sexually active adolescents performed an impulse control task during a functional magnetic resonance imaging (fMRI) scan and risky sexual behaviors were assessed through self-report. Sexual riskiness ratings were negatively associated with activation in the prefrontal cortex during response inhibition. These results suggest that diminished engagement of impulse control circuitry may contribute to sexual riskiness in adolescents. PMID:23835204

  12. Alcohol and behavioral control: cognitive and neural mechanisms.

    PubMed

    Vogel-Sprott, M; Easdon, C; Fillmore, M; Finn, P; Justus, A

    2001-01-01

    This article represents the proceedings of a symposium at the 2000 RSA Meeting in Denver, Colorado. The organizer/chair was Muriel Vogel-Sprott. The presentations were (1) Alcohol-induced impairment of inhibitory control: Some commonalities with attention deficit hyperactivity disorder, by Mark Fillmore; (2) Neural interactions that underlie response inhibition under alcohol: A functional magnetic resonance imaging investigation, by Craig Easdon; (3) Intentional control of behavior under alcohol, by Muriel Vogel-Sprott; and (4) Working memory and the disinhibiting effects of alcohol on passive avoidance learning, by Alicia Justius and Peter Finn.

  13. Of special humanitarian concern: U.S. refugee admissions since passage of the Refugee Act.

    PubMed

    Gallagher, D; Forbes, S; Fagan, P W

    1986-01-01

    The Refugee Act of 1980 is the 1st comprehensive legislation on the admission of refugees to the US; in the 5+ years since its enactment, over 500,000 refugees from more than 25 countries have been admitted to the US. This report assesses the effectiveness of the law in achieving its objectives in making and implementing decisions about the admission of refugees. The objectives of the Act include 1) a desire for a humanitarian response to refugee emergencies and a desire for control over that response, 2) a concern that ideological and geographic restrictions on refugee admissions be removed, and 3) a desire to balance international concerns and domestic impacts in making decisions on refugee admissions. The authors conclude that the refugee program does not serve the broad humanitarian purposes of previous parole programs, due to its stringent review requirements. The formal Congressional Consultations on refugee numbers should be rescheduled to allow regular Congressional input. The program needs a contingency budget for changing situations. The program needs more input from nongovernmental agencies and information sources. Recommendations on refugee admission numbers and allocations have not been well substantiated. Determinations as to which refugees are of "special humanitarian concern" are made solely on the basis of nationality; these decisions should also incorporate other factors. Admissions priorities are generally based on ties to this country, but this makes the refugee program a surrogate immigration program. Although the application of the refugee definition is difficult in practice, it forms the essence of the admission process. US staff must be trained to make these decisions; indecisiveness must not be allowed to jeopardize refugees.

  14. 14 CFR 27.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 27.923 Rotor drive system and control mechanism tests. (a) Each part tested as prescribed in this...

  15. 14 CFR 29.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 29.923 Rotor drive system and control mechanism tests. (a) Endurance tests, general. Each rotor...

  16. 14 CFR 29.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 29.923 Rotor drive system and control mechanism tests. (a) Endurance tests, general. Each rotor...

  17. 14 CFR 29.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 1 2014-01-01 2014-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 29.923 Rotor drive system and control mechanism tests. (a) Endurance tests, general. Each rotor...

  18. 14 CFR 27.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 27.923 Rotor drive system and control mechanism tests. (a) Each part tested as prescribed in this...

  19. 14 CFR 27.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 1 2013-01-01 2013-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 27.923 Rotor drive system and control mechanism tests. (a) Each part tested as prescribed in this...

  20. 14 CFR 29.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 29.923 Rotor drive system and control mechanism tests. (a) Endurance tests, general. Each rotor...

  1. 14 CFR 27.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 1 2012-01-01 2012-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 27.923 Rotor drive system and control mechanism tests. (a) Each part tested as prescribed in this...

  2. 14 CFR 29.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 29.923 Rotor drive system and control mechanism tests. (a) Endurance tests, general. Each rotor...

  3. 14 CFR 27.923 - Rotor drive system and control mechanism tests.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Rotor drive system and control mechanism... TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Powerplant Rotor Drive System § 27.923 Rotor drive system and control mechanism tests. (a) Each part tested as prescribed in this...

  4. Snail levels control the migration mechanism of mesenchymal tumor cells

    PubMed Central

    BELGIOVINE, CRISTINA; CHIESA, GIULIO; CHIODI, ILARIA; FRAPOLLI, ROBERTA; BONEZZI, KATIUSCIA; TARABOLETTI, GIULIA; D'INCALCI, MAURIZIO; MONDELLO, CHIARA

    2016-01-01

    Cancer cells use two major types of movement: Mesenchymal, which is typical of cells of mesenchymal origin and depends on matrix metalloproteinase (MMP) activity, and amoeboid, which is characteristic of cells with a rounded shape and relies on the activity of Rho-associated kinase (ROCK). The present authors previously demonstrated that, during neoplastic transformation, telomerase-immortalized human fibroblasts (cen3tel cells) acquired a ROCK-dependent/MMP independent mechanism of invasion, mediated by the downregulation of the ROCK cellular inhibitor Round (Rnd)3/RhoE. In the present study, cen3tel transformation was also demonstrated to be paralleled by downregulation of Snail, a major determinant of the mesenchymal movement. To test whether Snail levels could determine the type of movement adopted by mesenchymal tumor cells, Snail was ectopically expressed in tumorigenic cells. It was observed that ectopic Snail did not increase the levels of typical mesenchymal markers, but induced cells to adopt an MMP-dependent mechanism of invasion. In cells expressing ectopic Snail, invasion became sensitive to the MMP inhibitor Ro 28–2653 and insensitive to the ROCK inhibitor Y27632, suggesting that, once induced by Snail, the mesenchymal movement prevails over the amoeboid one. Snail-expressing cells had a more aggressive behavior in vivo, and exhibited increased tumor growth rate and metastatic ability. These results confirm the high plasticity of cancer cells, which can adopt different types of movement in response to changes in the expression of specific genes. Furthermore, the present findings indicate that Rnd3 and Snail are possible regulators of the type of invasion mechanism adopted by mesenchymal tumor cells. PMID:27347214

  5. Molecular mechanisms controlling proton pumping by bacteriorhodopsin. Final report

    SciTech Connect

    Crouch, Rosalie K.; Ebrey, Thomas G.

    2000-02-10

    Bacteriorhodopsin (bR) is the simplest biological system for the transduction of light energy. Light energy is directly converted to transmembrane proton gradient by a single, small membrane protein. The extraordinary stability of bR makes it an outstanding subject for bioenergetic studies. This project has focused on the role of interactions between key residues of the pigment involved in light-induced proton transfer. Methods to estimate the strength of these interactions and their correlation with the rate and efficiency of proton transfer have been developed. The concept of the coupling of the protonation states of key groups has been applied to individual steps of the proton transfer with the ultimate goal of understanding on the molecular level the driving forces for proton transport and the pathway of the transported proton in bT. The mechanism of light-induced proton release, uptake and the mechanism of recovery of initial state of bT has been examined. The experiments were performed with genetically engineered, site-specific mutants of bR. This has enabled us to characterize the role of individual amino acid residues in bR. Time resolved and low temperature absorption spectroscopy and light-induced photocurrent measurements were used in order to study the photochemical cycle and proton transfer in mutant pigments. Chemical modification and crosslinking of both the specific amino acids to the chromophore or to other amino acids were used to elucidate the role of light-induced conformational changes in the photocycle and the structure of the protein in the ground state. The results of this project provided new knowledge on the architecture of the proton transfer pathways inside the protein, on the mechanism of proton release in bR, and on the role of specific amino acid residues in the structure and function of bR.

  6. Automatic detection of AutoPEEP during controlled mechanical ventilation

    PubMed Central

    2012-01-01

    Background Dynamic hyperinflation, hereafter called AutoPEEP (auto-positive end expiratory pressure) with some slight language abuse, is a frequent deleterious phenomenon in patients undergoing mechanical ventilation. Although not readily quantifiable, AutoPEEP can be recognized on the expiratory portion of the flow waveform. If expiratory flow does not return to zero before the next inspiration, AutoPEEP is present. This simple detection however requires the eye of an expert clinician at the patient’s bedside. An automatic detection of AutoPEEP should be helpful to optimize care. Methods In this paper, a platform for automatic detection of AutoPEEP based on the flow signal available on most of recent mechanical ventilators is introduced. The detection algorithms are developed on the basis of robust non-parametric hypothesis testings that require no prior information on the signal distribution. In particular, two detectors are proposed: one is based on SNT (Signal Norm Testing) and the other is an extension of SNT in the sequential framework. The performance assessment was carried out on a respiratory system analog and ex-vivo on various retrospectively acquired patient curves. Results The experiment results have shown that the proposed algorithm provides relevant AutoPEEP detection on both simulated and real data. The analysis of clinical data has shown that the proposed detectors can be used to automatically detect AutoPEEP with an accuracy of 93% and a recall (sensitivity) of 90%. Conclusions The proposed platform provides an automatic early detection of AutoPEEP. Such functionality can be integrated in the currently used mechanical ventilator for continuous monitoring of the patient-ventilator interface and, therefore, alleviate the clinician task. PMID:22715924

  7. [Control of fertilization by self-incompatibility mechanisms].

    PubMed

    Fobis-Loisy, Isabelle; Gaude, Thierry

    2010-01-01

    Flowering plants (angiosperms) are the most prevalent and evolutionarily advanced group of plants. Reproductive strategies that promote cross-fertilization have played an essential role in the success of angiosperms as they contribute to genetic variability among plant species. A major genetic barrier to self-fertilization is self-incompatibility (SI), which allows female reproductive cells to discriminate between self- and non-self pollen and specifically reject self-pollen. In this review, we describe three SI mechanisms showing that different flowering plant families use distinct molecules for recognition of self as well as diverse biochemical pathways to arrest pollen tube growth.

  8. Mechanical control over valley magnetotransport in strained graphene

    NASA Astrophysics Data System (ADS)

    Ma, Ning; Zhang, Shengli; Liu, Daqing

    2016-05-01

    Recent experiments report that the graphene exhibits Landau levels (LLs) that form in the presence of a uniform strain pseudomagnetic field with magnitudes up to hundreds of tesla. We further reveal that the strain removes the valley degeneracy in LLs, and leads to a significant valley polarization with inversion symmetry broken. This accordingly gives rise to the well separated valley Hall plateaus and Shubnikov-de Haas oscillations. These effects are absent in strainless graphene, and can be used to generate and detect valley polarization by mechanical means, forming the basis for the new paradigm "valleytronics" applications.

  9. Eco-hydrological feedback mechanisms control ecological services in wetlands

    NASA Astrophysics Data System (ADS)

    Coletti, J.; Hinz, C.; Vogwill, R.; Tareque, H.; Hipsey, M. R.

    2011-12-01

    Wetland ecosystems contain various feedback mechanisms between their abiotc and biotic components. The feedbacks are triggered by climate and propagate into patterns of environment partitioning based on distinct zones of hydrological function that vary in time and space. This partitioning co-evolves with vegetation, defines carbon metabolism and creates niches that govern patterns of flora and fauna abundance and distribution. Using a minimalistic model for wetland eco-hydrology, we explore vegetation adaptation to climate variability and the net metabolism of a wetland ecosystem given a range of climate conditions. We then apply the model to characterize the changes in niche habitat availability for a tortoise population endangered by a drying climate.

  10. Biochemical Mechanisms Controlling Terminal Electron Transfer in Geobacter sulfurreducens

    NASA Astrophysics Data System (ADS)

    Helmus, R.; Liermann, L. J.; Brantley, S. L.; Tien, M.

    2009-04-01

    The ability of Geobacter sulfurreducens to use a variety of metals as terminal electron acceptors (TEAs) for cellular respiration makes it attractive for use in bioremediation and implies its importance to mineral cycling in the environment. This study is aimed at understanding the biochemical mechanisms that allow Geobacter sulfurreducens to use soluble and insoluble iron and manganese forms as TEAs for cellular respiration and is the first of its kind to address the kinetics of manganese use as a TEA by G. sulfurreducens. First, G. sulfurreducens was conditioned to grow on various soluble and insoluble iron and manganese forms. G. sulfurreducens demonstrated enhanced growth rates when cultured using soluble TEAs compared with insoluble TEAs. However, the lower growth rate on insoluble iron compared with soluble iron was observed concomitantly with a 1-2 log lower cell density in stationary phase in insoluble iron cultures and a lower growth yield per electron donor used in log growth phase. Furthermore, the growth yield per electron was similar with both soluble and insoluble iron. These results suggest that the net amount of energy available for biomass production achieved from reducing insoluble iron is lower than with soluble iron, which may be due to a different biochemical mechanism catalyzing the electron transfer to TEA dependent upon the solubility of the TEA. One scenario consistent with this notion is that protein(s) in the outer membrane of G. sulfurreducens that transfers electrons to insoluble TEAs does so in a manner that uncouples electron flow from the proton pump in the cellular membrane, similar to what we have observed with Shewanella oneidensis MR-1. Both the growth rate and growth yield of G. sulfurreducens on insoluble manganese were higher than on insoluble iron, indicating that there is a difference in the flow of electrons to the TEA in these two situations. While the different redox potentials of these elements may affect these values

  11. Cognitive Control Mechanisms, Emotion & Memory: A neural perspective with implications for psychopathology

    PubMed Central

    Banich, Marie T.; Mackiewicz, Kristen L.; Depue, Brendan E.; Whitmer, Anson; Miller, Gregory A.; Heller, Wendy

    2009-01-01

    In this paper we provide a focused review of the literature examining neural mechanisms involved in cognitive control over memory processes that can influence, and in turn are influenced, by emotional processes. The review is divided into two parts, the first focusing on working memory and the second on long-term memory. With regard to working memory, we discuss the neural bases of 1) control mechanisms that can select against distracting emotional information, 2) mechanisms that can regulate emotional reactions or responses, 3) how mood state influences cognitive control, and 4) individual differences in control mechanisms. For long-term memory, we briefly review 1) the neural substrates of emotional memory, 2) the cognitive and neural mechanisms that are involved in controlling emotional memories and 3) how these systems are altered in post-traumatic stress disorder. Finally, we consider tentative generalizations that can be drawn from this relatively unexplored conjunction of research endeavors. PMID:18948135

  12. Sexual Orientation Biases Attentional Control: A Possible Gaydar Mechanism

    PubMed Central

    Colzato, Lorenza S.; van Hooidonk, Linda; van den Wildenberg, Wery P. M.; Harinck, Fieke; Hommel, Bernhard

    2010-01-01

    Homosexuals are believed to have a “sixth sense” for recognizing each other, an ability referred to as gaydar. We considered that being a homosexual might rely on systematic practice of processing relatively specific, local perceptual features, which might lead to a corresponding chronic bias of attentional control. This was tested by comparing male and female homosexuals and heterosexuals – brought up in the same country and culture and matched in terms of race, intelligence, sex, mood, age, personality, religious background, educational style, and socio-economic situation – in their efficiency to process global and local features of hierarchically-constructed visual stimuli. Both homosexuals and heterosexuals showed better performance on global features – the standard global precedence effect. However, this effect was significantly reduced in homosexuals, suggesting a relative preference for detail. Findings are taken to demonstrate chronic, generalized biases in attentional control parameters that reflect the selective reward provided by the respective sexual orientation. PMID:21607070

  13. Autophagy in cardiac metabolic control: Novel mechanisms for cardiovascular disorders.

    PubMed

    Yang, Yufei; Zhao, Cong; Yang, Pingzhen; Wang, Xianbao; Wang, Lizi; Chen, Aihua

    2016-09-01

    As an extensively studied quality control system, autophagy is responsible for clearance of dysfunctional organelles and damaged marcomolecules in cells. In addition to its biological recycling function, autophagy plays a significant role in the pathogenesis of metabolic syndromes such as obesity and diabetes. In particular, metabolic disorders contribute to cardiovascular disease development. As energy required to maintain cardiac cells functional is immense, disturbances in the balance between anabolic and catabolic metabolism possibly contribute to cardiovascular disorders. Therefore, an urgent need to expand our knowledge on the role of autophagy on the metabolic regulation of hearts emerges. In this review, the potential relationship between autophagic activity and cardiac metabolism is explored and we also discuss how dysregulated autophagy leads to severe cardiac disorders from the perspective of metabolic control. PMID:27191043

  14. Mechanisms of daughter cell-size control during cell division.

    PubMed

    Kiyomitsu, Tomomi

    2015-05-01

    Daughter cell size is tightly regulated during cell division. In animal cells, the position of the anaphase spindle specifies the cell cleavage site to dictate the relative size of the daughter cells. Although spindle orientation is regulated by dynein-dependent cortical pulling forces exerted on astral microtubules in many cell types, it was unclear how these forces are precisely regulated to center or displace the spindle. Recently, intrinsic signals derived from chromosomes or spindle poles have been demonstrated to regulate dynein-dependent pulling forces in symmetrically dividing cells. Unexpectedly, myosin-dependent contractile forces have also been shown to control spindle position by altering the cellular boundaries during anaphase. In this review, I discuss how dynein- and myosin-dependent forces are coordinately regulated to control daughter cell size. PMID:25548067

  15. Neural mechanisms underlying auditory feedback control of speech.

    PubMed

    Tourville, Jason A; Reilly, Kevin J; Guenther, Frank H

    2008-02-01

    The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling. Neural responses were measured while subjects spoke monosyllabic words under two conditions: (i) normal auditory feedback of their speech and (ii) auditory feedback in which the first formant frequency of their speech was unexpectedly shifted in real time. Acoustic measurements showed compensation to the shift within approximately 136 ms of onset. Neuroimaging revealed increased activity in bilateral superior temporal cortex during shifted feedback, indicative of neurons coding mismatches between expected and actual auditory signals, as well as right prefrontal and Rolandic cortical activity. Structural equation modeling revealed increased influence of bilateral auditory cortical areas on right frontal areas during shifted speech, indicating that projections from auditory error cells in posterior superior temporal cortex to motor correction cells in right frontal cortex mediate auditory feedback control of speech.

  16. Mechanisms of motor adaptation in reactive balance control.

    PubMed

    Welch, Torrence D J; Ting, Lena H

    2014-01-01

    Balance control must be rapidly modified to provide stability in the face of environmental challenges. Although changes in reactive balance over repeated perturbations have been observed previously, only anticipatory postural adjustments preceding voluntary movements have been studied in the framework of motor adaptation and learning theory. Here, we hypothesized that adaptation occurs in task-level balance control during responses to perturbations due to central changes in the control of both anticipatory and reactive components of balance. Our adaptation paradigm consisted of a Training set of forward support-surface perturbations, a Reversal set of novel countermanding perturbations that reversed direction, and a Washout set identical to the Training set. Adaptation was characterized by a change in a motor variable from the beginning to the end of each set, the presence of aftereffects at the beginning of the Washout set when the novel perturbations were removed, and a return of the variable at the end of the Washout to a level comparable to the end of the Training set. Task-level balance performance was characterized by peak center of mass (CoM) excursion and velocity, which showed adaptive changes with repetitive trials. Only small changes in anticipatory postural control, characterized by body lean and background muscle activity were observed. Adaptation was found in the evoked long-latency muscular response, and also in the sensorimotor transformation mediating that response. Finally, in each set, temporal patterns of muscle activity converged towards an optimum predicted by a trade-off between maximizing motor performance and minimizing muscle activity. Our results suggest that adaptation in balance, as well as other motor tasks, is mediated by altering central sensitivity to perturbations and may be driven by energetic considerations. PMID:24810991

  17. Mechanical override for electronic fuel control on a piston engine

    SciTech Connect

    Jedrziewski, S.T.

    1987-02-17

    This patent describes an apparatus for controlling the throttle of a fuel burning engine from either a shaft powered by automatic fuel control equipment or by the translational motion of a manually positioned throttle lever. The apparatus is attached to the engine via a throttle shaft extending outwardly from the wall of the engine fuel-air metering system, the apparatus comprising: an outer housing shell having a generally cylindrical interior and a lever arm rigidly attached to and extending radially away from the periphery thereof, the lever end furthest from the periphery of the outer housing shell being pivotally connected to the manual throttle lever; an output spool mounted for rotation within one end of the outer housing shell, the output spool having an axial boring at its outermost end sized to receive and be secured to the throttle shaft. The inward facing end of the output spool is coaxially formed into a cup shaped annulus; and an input spool having a generally cylindrical shape, the input spool mounted for rotation within the second end of the outer housing shell, the innermost end of the input spool being sized to fit within the cup shaped annulus on the inward facing end of the output spool. The input spool has an axial boring at its outermost end sized to receive and be secured to a shaft powered by the automatic fuel control equipment.

  18. Development of passive-controlled HUB (teetered brake & damper mechanism) of horizontal axis wind turbine

    SciTech Connect

    Shimizu, Yukimaru; Kamada, Yasunari; Maeda, Takao

    1997-12-31

    For the purpose of the improvement of reliability of the Mega-Watt wind turbine, this paper indicates the development of an original mechanism for the passive-controlled hub, which has the effects of braking and damping on aerodynamic forces. This mechanism is useful for variable speed control of the large wind turbine. The passive-controlled hub is the combination of two mechanisms. One is the passive-teetered and damping mechanism, and the other is the passive-variable-pitch mechanism. These mechanism are carried out by the combination of the teetering and feathering motions. When the wind speed exceeds the rated wind speed, the blade is passively teetered in a downwind direction and, simultaneously, a feathering mechanism, which is linked to the teetering mechanism through a connecting rods, is activated. Testing of the model horizontal axis wind turbine in a wind tunnel showed that the passive-controlled hub mechanism can suppress the over-rotational speed of the rotor. By the application of the passive-controlled hub mechanism, the maximum rotor speed is reduced to about 60%.

  19. Control of mechanically activated polymersome fusion: Factors affecting fusion

    SciTech Connect

    Henderson, Ian M.; Paxton, Walter F.

    2014-12-15

    Previously we have studied the mechanically-activated fusion of extruded (200 nm) polymer vesicles into giant polymersomes using agitation in the presence of salt. In this study we have investigated several factors contributing to this phenomenon, including the effects of (i) polymer vesicle concentration, (ii) agitation speed and duration, and iii) variation of the salt and its concentration. It was found that increasing the concentration of the polymer dramatically increases the production of giant vesicles through the increased collisions of polymersomes. Our investigations also found that increasing the frequency of agitation increased the efficiency of fusion, though ultimately limited the size of vesicle which could be produced due to the high shear involved. Finally it was determined that salt-mediation of the fusion process was not limited to NaCl, but is instead a general effect facilitated by the presence of solvated ionic compounds, albeit with different salts initiating fusion at different concentration.

  20. Control of mechanically activated polymersome fusion: Factors affecting fusion

    DOE PAGES

    Henderson, Ian M.; Paxton, Walter F.

    2014-12-15

    Previously we have studied the mechanically-activated fusion of extruded (200 nm) polymer vesicles into giant polymersomes using agitation in the presence of salt. In this study we have investigated several factors contributing to this phenomenon, including the effects of (i) polymer vesicle concentration, (ii) agitation speed and duration, and iii) variation of the salt and its concentration. It was found that increasing the concentration of the polymer dramatically increases the production of giant vesicles through the increased collisions of polymersomes. Our investigations also found that increasing the frequency of agitation increased the efficiency of fusion, though ultimately limited the sizemore » of vesicle which could be produced due to the high shear involved. Finally it was determined that salt-mediation of the fusion process was not limited to NaCl, but is instead a general effect facilitated by the presence of solvated ionic compounds, albeit with different salts initiating fusion at different concentration.« less