Sample records for adobe pdf format

  1. Threat Modelling Adobe PDF

    DTIC Science & Technology

    2012-08-01

    this attack sensitive information relating to their two-factor authentication process, employed within RSA’s products, was stolen; potentially... authenticated session the victim has with another website. This could allow the attacker to impersonate the victim or obtain sensitive information...all that is not blacklisted is authorised . We will outline relevant security settings in this section. 4.1 Adobe End-User Security Modification

  2. Desktop document delivery using portable document format (PDF) files and the Web.

    PubMed Central

    Shipman, J P; Gembala, W L; Reeder, J M; Zick, B A; Rainwater, M J

    1998-01-01

    Desktop access to electronic full-text literature was rated one of the most desirable services in a client survey conducted by the University of Washington Libraries. The University of Washington Health Sciences Libraries (UW HSL) conducted a ten-month pilot test from August 1996 to May 1997 to determine the feasibility of delivering electronic journal articles via the Internet to remote faculty. Articles were scanned into Adobe Acrobat Portable Document Format (PDF) files and delivered to individuals using Multipurpose Internet Mail Extensions (MIME) standard e-mail attachments and the Web. Participants retrieved scanned articles and used the Adobe Acrobat Reader software to view and print files. The pilot test required a special programming effort to automate the client notification and file deletion processes. Test participants were satisfied with the pilot test despite some technical difficulties. Desktop delivery is now offered as a routine delivery method from the UW HSL. PMID:9681165

  3. Desktop document delivery using portable document format (PDF) files and the Web.

    PubMed

    Shipman, J P; Gembala, W L; Reeder, J M; Zick, B A; Rainwater, M J

    1998-07-01

    Desktop access to electronic full-text literature was rated one of the most desirable services in a client survey conducted by the University of Washington Libraries. The University of Washington Health Sciences Libraries (UW HSL) conducted a ten-month pilot test from August 1996 to May 1997 to determine the feasibility of delivering electronic journal articles via the Internet to remote faculty. Articles were scanned into Adobe Acrobat Portable Document Format (PDF) files and delivered to individuals using Multipurpose Internet Mail Extensions (MIME) standard e-mail attachments and the Web. Participants retrieved scanned articles and used the Adobe Acrobat Reader software to view and print files. The pilot test required a special programming effort to automate the client notification and file deletion processes. Test participants were satisfied with the pilot test despite some technical difficulties. Desktop delivery is now offered as a routine delivery method from the UW HSL.

  4. Deep PDF parsing to extract features for detecting embedded malware.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Munson, Miles Arthur; Cross, Jesse S.

    2011-09-01

    The number of PDF files with embedded malicious code has risen significantly in the past few years. This is due to the portability of the file format, the ways Adobe Reader recovers from corrupt PDF files, the addition of many multimedia and scripting extensions to the file format, and many format properties the malware author may use to disguise the presence of malware. Current research focuses on executable, MS Office, and HTML formats. In this paper, several features and properties of PDF Files are identified. Features are extracted using an instrumented open source PDF viewer. The feature descriptions of benignmore » and malicious PDFs can be used to construct a machine learning model for detecting possible malware in future PDF files. The detection rate of PDF malware by current antivirus software is very low. A PDF file is easy to edit and manipulate because it is a text format, providing a low barrier to malware authors. Analyzing PDF files for malware is nonetheless difficult because of (a) the complexity of the formatting language, (b) the parsing idiosyncrasies in Adobe Reader, and (c) undocumented correction techniques employed in Adobe Reader. In May 2011, Esparza demonstrated that PDF malware could be hidden from 42 of 43 antivirus packages by combining multiple obfuscation techniques [4]. One reason current antivirus software fails is the ease of varying byte sequences in PDF malware, thereby rendering conventional signature-based virus detection useless. The compression and encryption functions produce sequences of bytes that are each functions of multiple input bytes. As a result, padding the malware payload with some whitespace before compression/encryption can change many of the bytes in the final payload. In this study we analyzed a corpus of 2591 benign and 87 malicious PDF files. While this corpus is admittedly small, it allowed us to test a system for collecting indicators of embedded PDF malware. We will call these indicators features

  5. Creating an Interactive PDF

    ERIC Educational Resources Information Center

    Branzburg, Jeffrey

    2008-01-01

    There are many ways to begin a PDF document using Adobe Acrobat. The easiest and most popular way is to create the document in another application (such as Microsoft Word) and then use the Adobe Acrobat software to convert it to a PDF. In this article, the author describes how he used Acrobat's many tools in his project--an interactive…

  6. PDF Lecture Materials for Online and ``Flipped'' Format Astronomy Courses

    NASA Astrophysics Data System (ADS)

    Kary, D. M.; Eisberg, J.

    2013-04-01

    Online astronomy courses typically rely on students reading the textbook and/or a set of text-based lecture notes to replace the “lecture” material. However, many of our students report that this is much less engaging than in-person lectures, especially given the amount of interactive work such as “think-pair-share” problems done in many astronomy classes. Students have similarly criticized direct lecture-capture. To address this, we have developed a set of PowerPoint-style presentations with embedded lecture audio combined with prompts for student interaction including think-pair-share questions. These are formatted PDF packages that can be used on a range of different computers using free software. The presentations are first developed using Microsoft PowerPoint software. Audio recordings of scripted lectures are then synchronized with the presentations and the entire package is converted to PDF using Adobe Presenter. This approach combines the ease of editing that PowerPoint provides along with the platform-independence of PDF. It's easy to add, remove, or edit individual slides as needed, and PowerPoint supports internal links so that think-pair-share questions can be inserted with links to feedback based on the answers selected. Modern PDF files support animated visuals with synchronized audio and they can be read using widely available free software. Using these files students in an online course can get many of the benefits of seeing and hearing the course material presented in an in-person lecture format. Students needing extra help in traditional lecture classes can use these presentations to help review the materials covered in lecture. Finally, the presentations can be used in a “flipped” format in which students work through the presentations outside of class time while spending the “lecture” time on in-class interaction.

  7. Extra dimensions: 3d and time in pdf documentation

    NASA Astrophysics Data System (ADS)

    Graf, N. A.

    2008-07-01

    High energy physics is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standard Universal 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide audience. In this talk, we present examples of HEP applications which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input. Using this technique, higher dimensional data, such as LEGO plots or time-dependent information can be included in PDF files. In principle, a complete event display, with full interactivity, can be incorporated into a PDF file. This would allow the end user not only to customize the view and representation of the data, but to access the underlying data itself.

  8. Embedding and Publishing Interactive, 3-Dimensional, Scientific Figures in Portable Document Format (PDF) Files

    PubMed Central

    Barnes, David G.; Vidiassov, Michail; Ruthensteiner, Bernhard; Fluke, Christopher J.; Quayle, Michelle R.; McHenry, Colin R.

    2013-01-01

    With the latest release of the S2PLOT graphics library, embedding interactive, 3-dimensional (3-d) scientific figures in Adobe Portable Document Format (PDF) files is simple, and can be accomplished without commercial software. In this paper, we motivate the need for embedding 3-d figures in scholarly articles. We explain how 3-d figures can be created using the S2PLOT graphics library, exported to Product Representation Compact (PRC) format, and included as fully interactive, 3-d figures in PDF files using the movie15 LaTeX package. We present new examples of 3-d PDF figures, explain how they have been made, validate them, and comment on their advantages over traditional, static 2-dimensional (2-d) figures. With the judicious use of 3-d rather than 2-d figures, scientists can now publish, share and archive more useful, flexible and faithful representations of their study outcomes. The article you are reading does not have embedded 3-d figures. The full paper, with embedded 3-d figures, is recommended and is available as a supplementary download from PLoS ONE (File S2). PMID:24086243

  9. Embedding and publishing interactive, 3-dimensional, scientific figures in Portable Document Format (PDF) files.

    PubMed

    Barnes, David G; Vidiassov, Michail; Ruthensteiner, Bernhard; Fluke, Christopher J; Quayle, Michelle R; McHenry, Colin R

    2013-01-01

    With the latest release of the S2PLOT graphics library, embedding interactive, 3-dimensional (3-d) scientific figures in Adobe Portable Document Format (PDF) files is simple, and can be accomplished without commercial software. In this paper, we motivate the need for embedding 3-d figures in scholarly articles. We explain how 3-d figures can be created using the S2PLOT graphics library, exported to Product Representation Compact (PRC) format, and included as fully interactive, 3-d figures in PDF files using the movie15 LaTeX package. We present new examples of 3-d PDF figures, explain how they have been made, validate them, and comment on their advantages over traditional, static 2-dimensional (2-d) figures. With the judicious use of 3-d rather than 2-d figures, scientists can now publish, share and archive more useful, flexible and faithful representations of their study outcomes. The article you are reading does not have embedded 3-d figures. The full paper, with embedded 3-d figures, is recommended and is available as a supplementary download from PLoS ONE (File S2).

  10. Extra Dimensions: 3D and Time in PDF Documentation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Graf, Norman A.; /SLAC

    2011-11-10

    High energy physics is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standardmore » Universal 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide audience. In this talk, we present examples of HEP applications which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input. Using this technique, higher dimensional data, such as LEGO plots or time-dependent information can be included in PDF files. In principle, a complete event display, with full interactivity, can be incorporated into a PDF file. This would allow the end user not only to customize the view and representation of the data, but to access the underlying data itself.« less

  11. Evaluation of Adobe[R] Presenter as a Teaching Tool

    ERIC Educational Resources Information Center

    Grabowski, Michelle

    2010-01-01

    Adobe[R] Presenter software provides educators with a tool to create narrated distance learning presentations. This article describes Adobe[R] Presenter's many features and explains which most strongly affect learning. Six Adobe[R] Presenter trainings were presented to 62 volunteers preparing to provide information at a public outreach event. One…

  12. E-submission Format for Sub-chronic and Chronic Studies

    EPA Pesticide Factsheets

    The purpose of this document is to suggest the format for final reports and to provide instructions for creation of Adobe PDF electronic submission documents for electronic submission of sub-chronic and chronic studies for pesticides.

  13. 47 CFR 1.913 - Application and notification forms; electronic and manual filing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Portable Document Format (PDF) whenever possible. (2) Any associated documents submitted with an... possible. The attachment should be uploaded via ULS in Adobe Acrobat Portable Document Format (PDF... the table of contents, should be in Adobe Acrobat Portable Document Format (PDF) whenever possible...

  14. Extra dimensions: 3D in PDF documentation

    DOE PAGES

    Graf, Norman A.

    2011-01-11

    Experimental science is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standard Universalmore » 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide, non-technical audience. We discuss how the field of radiation imaging could benefit from incorporating full 3D information about not only the detectors, but also the results of the experimental analyses, in its electronic publications. In this article, we present examples drawn from high-energy physics, mathematics and molecular biology which take advantage of this functionality. Furthermore, we demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input.« less

  15. 47 CFR 1.913 - Application and notification forms; electronic and manual filing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... notifications whenever possible. The files, other than the ASCII table of contents, should be in Adobe Acrobat... possible. The attachment should be uploaded via ULS in Adobe Acrobat Portable Document Format (PDF... the table of contents, should be in Adobe Acrobat Portable Document Format (PDF) whenever possible...

  16. Extra dimensions: 3D and time in PDF documentation

    NASA Astrophysics Data System (ADS)

    Graf, N. A.

    2011-01-01

    Experimental science is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standard Universal 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide, non-technical audience. We discuss how the field of radiation imaging could benefit from incorporating full 3D information about not only the detectors, but also the results of the experimental analyses, in its electronic publications. In this article, we present examples drawn from high-energy physics, mathematics and molecular biology which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input.

  17. Extra Dimensions: 3D and Time in PDF Documentation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Graf, N.A.; /SLAC

    2012-04-11

    Experimental science is replete with multi-dimensional information which is often poorly represented by the two dimensions of presentation slides and print media. Past efforts to disseminate such information to a wider audience have failed for a number of reasons, including a lack of standards which are easy to implement and have broad support. Adobe's Portable Document Format (PDF) has in recent years become the de facto standard for secure, dependable electronic information exchange. It has done so by creating an open format, providing support for multiple platforms and being reliable and extensible. By providing support for the ECMA standard Universalmore » 3D (U3D) file format in its free Adobe Reader software, Adobe has made it easy to distribute and interact with 3D content. By providing support for scripting and animation, temporal data can also be easily distributed to a wide, non-technical audience. We discuss how the field of radiation imaging could benefit from incorporating full 3D information about not only the detectors, but also the results of the experimental analyses, in its electronic publications. In this article, we present examples drawn from high-energy physics, mathematics and molecular biology which take advantage of this functionality. We demonstrate how 3D detector elements can be documented, using either CAD drawings or other sources such as GEANT visualizations as input.« less

  18. Source Fingerprinting in Adobe PDF Files

    DTIC Science & Technology

    2013-12-01

    targeted, opportunistic attacks [2]. Figures from F -Secure for 2008–2010 indicate that anywhere from 28–61% of targeted attacks involved PDF exploits...digit byte offset into the file, a five-digit generation number, and either the character ‘ f ’ or ‘n’, indicating whether the object defined on that line...Walk through a path, extracting n-grams from files and associating # them with the directory that contains them. E.g., the file # ./my_docs/ foo

  19. 76 FR 27309 - Committee on Measures of Student Success

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... version of this document is the document published in the Federal Register. Free Internet access to the... text or Adobe Portable Document Format (PDF) on the Internet at the following site: http://www.ed.gov/news/fed-register/index.html . To use PDF you must have Adobe Acrobat Reader, which is available free...

  20. Whittier Tunnel, Transportation & Public Facilities, State of Alaska

    Science.gov Websites

    ONLINE (or choose to download in Adobe PDF or Excel format) Summer May 1 - Sept 30 PDF document | Excel document Winter Oct 1 - Apr 30 PDF document | Excel document Current Regulations: PDF document | Word

  1. Adobe Mining grows during tough times

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scott, F.E.

    1983-05-01

    This article describes how a mining company produces coal at its 10 surface operations 24 hrs. a day, 7 days a week, and runs its 3 preparation plants 24 hrs. a day, 5 days a week. In 1982 Adobe topped 2 million tons per year in coal production. A significant savings is realized because Adobe has its own shop to rebuild all major engines and power train components when necessary. Adobe origins and safety and reclamation are discussed.

  2. Preservation of adobe buildings. Study of materials

    NASA Astrophysics Data System (ADS)

    Velosa, A.; Rocha, F.; Costa, C.; Varum, H.

    2012-04-01

    Adobe buildings are common in the central region of Portugal due to the lack of natural stone in the surrounding area. This type of construction technique lasted until the 20th Century, at which time cementitious materials, with faster hardening and greater structural capacity substituted traditional materials and techniques. Currently, a significant percentage of these buildings is vacant and many are degraded and in need of conservation actions. Adobes from central Portugal are distinctive as they are lightly coloured and made from air lime and quarry sand. Although some adobes were manufactured locally, most were produced almost 'industrially' and sold to nearby regions. In order to preserve this heritage, conservation actions must be undertaken. So as to ensure the adequacy of these actions and compatibility between original materials and new ones, a thorough study of adobe compostion is mandatory. The current study is an initial step in the characterization of earth based construction materials from central Portugal. Adobe samples were collected from residential buildings in two different locations. The determination of the composition of adobe blocks encompassed the determination of the binder fraction and of their chemical composition and also the particle size analysis of the aggregate. For this purpose FRX analysis, acid dissolution and dry sieving were performed. Methylene blue test was also executed in order to determine the clay fraction. Additionally, the mineral composition of powder samples and oriented samples was performed using XRD analysis in order to determine the clay minerals present in the blocks. As adobe blocks are extremely prone to the action of water the Geelong test was undertaken in order to provide information in terms of durability. It was concluded that air lime was generally used in adobe compositions. However, the clay content varies in adobes from different regions, providing distinct durability characteristics to these materials.

  3. A GPU accelerated PDF transparency engine

    NASA Astrophysics Data System (ADS)

    Recker, John; Lin, I.-Jong; Tastl, Ingeborg

    2011-01-01

    As commercial printing presses become faster, cheaper and more efficient, so too must the Raster Image Processors (RIP) that prepare data for them to print. Digital press RIPs, however, have been challenged to on the one hand meet the ever increasing print performance of the latest digital presses, and on the other hand process increasingly complex documents with transparent layers and embedded ICC profiles. This paper explores the challenges encountered when implementing a GPU accelerated driver for the open source Ghostscript Adobe PostScript and PDF language interpreter targeted at accelerating PDF transparency for high speed commercial presses. It further describes our solution, including an image memory manager for tiling input and output images and documents, a PDF compatible multiple image layer blending engine, and a GPU accelerated ICC v4 compatible color transformation engine. The result, we believe, is the foundation for a scalable, efficient, distributed RIP system that can meet current and future RIP requirements for a wide range of commercial digital presses.

  4. Heads Up

    MedlinePlus

    ... HEADS UP Resources Training Custom PDFs Mobile Apps Videos Graphics Podcasts Social Media File Formats Help: How do I view different file formats (PDF, DOC, PPT, MPEG) on this site? Adobe PDF file Microsoft PowerPoint ... file Apple Quicktime file RealPlayer file Text file ...

  5. Characterization, reproduction and optimization of traditional adobe bricks

    NASA Astrophysics Data System (ADS)

    Ioannou, Ioannis; Eftychiou, Marina; Costi de Castrillo, Maria; Illampas, Rogiros

    2013-04-01

    Adobe bricks were first introduced 10-12,000 years ago. Extensive use of the material throughout the centuries has led to strong local traditions of building with earth and has established adobe masonry as an important feature of the international architectural heritage. Today, despite no longer being a prevalent building material, adobes are still in use, since a number of earthen structures survive worldwide. Furthermore, the simplicity, low cost and almost negligible embodied energy associated with the production of adobes, as well as their good thermal and acoustic properties, render them an attractive option for use in contemporary sustainable construction. Therefore, several ongoing research projects internationally investigate the physicochemical and mechanical properties of traditional adobe bricks and the design/production of optimized adobes, with improved characteristics, for use in contemporary architecture. Here, we present ongoing research on adobe bricks carried out in the framework of the project E& IXEIPH EI / POION/0609/41, which is co-funded by the European Regional Development Fund and the Republic of Cyprus, through the Cyprus Research Promotion Foundation. Our work focuses on the characterization of traditional adobes, their reproduction and optimization in the laboratory to produce materials with improved physicomechanical properties. Results up-to-date show that traditional adobes are mostly composed of random quantities of silt and clay. Calcite is also predominant in relevant X-ray diffraction analyses. The average capillary water absorption coefficient (measured against a saturated sponge surface) of samples collected from market suppliers rarely exceeds 1 mm/min1 -2, while their thermal conductivity is around 0.55 W/mK. The response of traditional adobes to compression is characterized by intense deformability. The average compressive strength recorded depends on the form of test specimen (cube, cylinder, prism). Samples with aspect

  6. The magic of solar adobe

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thayer, B.M.

    1996-01-01

    This article describes the energy efficient features of a house in Santa Fe. It is a modern version of ancient adobe house of the area. The homes solar features added no net cost to its construction and save more than 80% on conventional energy use. Topic areas covered are as follows: art of adobe; solar design; back-up heat; energy and cost performance.

  7. An easy and effective approach to manage radiologic portable document format (PDF) files using iTunes.

    PubMed

    Qian, Li Jun; Zhou, Mi; Xu, Jian Rong

    2008-07-01

    The objective of this article is to explain an easy and effective approach for managing radiologic files in portable document format (PDF) using iTunes. PDF files are widely used as a standard file format for electronic publications as well as for medical online documents. Unfortunately, there is a lack of powerful software to manage numerous PDF documents. In this article, we explain how to use the hidden function of iTunes (Apple Computer) to manage PDF documents as easily as managing music files.

  8. The ABCs of PDFs.

    ERIC Educational Resources Information Center

    Adler, Steve

    2000-01-01

    Explains the use of Adobe Acrobat's Portable Document Format (PDF) for school Web sites and Intranets. Explains the PDF workflow; components for Web-based PDF delivery, including the Web server, preparing content of the PDF files, and the browser; incorporating PDFs into the Web site; incorporating multimedia; and software. (LRW)

  9. 77 FR 49788 - National Committee on Foreign Medical Education and Accreditation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... official version of this document is the document published in the Federal Register. Free Internet access... Document Format (PDF). To use PDF, you must have Adobe Acrobat Reader, which is available free at the site...

  10. DICOM to print, 35-mm slides, web, and video projector: tutorial using Adobe Photoshop.

    PubMed

    Gurney, Jud W

    2002-10-01

    Preparing images for publication has dealt with film and the photographic process. With picture archiving and communications systems, many departments will no longer produce film. This will change how images are produced for publication. DICOM, the file format for radiographic images, has to be converted and then prepared for traditional publication, 35-mm slides, the newest techniques of video projection, and the World Wide Web. Tagged image file format is the common format for traditional print publication, whereas joint photographic expert group is the current file format for the World Wide Web. Each medium has specific requirements that can be met with a common image-editing program such as Adobe Photoshop (Adobe Systems, San Jose, CA). High-resolution images are required for print, a process that requires interpolation. However, the Internet requires images with a small file size for rapid transmission. The resolution of each output differs and the image resolution must be optimized to match the output of the publishing medium.

  11. 78 FR 15009 - Extension of Deadline; Gaining Early Awareness and Readiness for Undergraduate Programs (GEAR UP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... official version of this document is the document published in the Federal Register. Free Internet access... free, at 1- 800-877-8339. Accessible Format: Individuals with disabilities can obtain this document in... Document Format (PDF). To use PDF, you must have Adobe Acrobat Reader, which is available free at this site...

  12. 77 FR 27219 - Applications for New Awards; Promise Neighborhoods Program-Implementation Grant Competition...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-09

    ... official version of this document is the document published in the Federal Register. Free Internet access... (TTY), call the Federal Relay Service (FRS), toll free, at 1- 800-877-8339. Accessible Format... Document Format (PDF). To use PDF you must have Adobe Acrobat Reader, which is available free at the site...

  13. New Powder Diffraction File (PDF-4) in relational database format: advantages and data-mining capabilities.

    PubMed

    Kabekkodu, Soorya N; Faber, John; Fawcett, Tim

    2002-06-01

    The International Centre for Diffraction Data (ICDD) is responding to the changing needs in powder diffraction and materials analysis by developing the Powder Diffraction File (PDF) in a very flexible relational database (RDB) format. The PDF now contains 136,895 powder diffraction patterns. In this paper, an attempt is made to give an overview of the PDF-4, search/match methods and the advantages of having the PDF-4 in RDB format. Some case studies have been carried out to search for crystallization trends, properties, frequencies of space groups and prototype structures. These studies give a good understanding of the basic structural aspects of classes of compounds present in the database. The present paper also reports data-mining techniques and demonstrates the power of a relational database over the traditional (flat-file) database structures.

  14. Apparatus for forming adobe bricks and drilling wells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kinnamon, H. D.

    1985-02-12

    An improved apparatus for the continuous and relatively labor-free fabrication of adobe bricks and the forcing of well casings into the earth. With regard to forming adobe bricks, a rotating table carries the bricks being processed from one station to the next and a novel means for applying unusually high forming pressures permits immediate forming and ejection of the bricks from the forms while at the same time producing adobe bricks of improved quality and hardness characteristics.

  15. Adobe unlocks Cherry Canyon, other zones in prolific Barstow unit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brewster, J.

    1979-08-01

    Recent discoveries by Adobe Oil and Gas Corp. in the Barstow unit skirting the Pecos River near Pecos, Texas have extended the Cherry Canyon play approx. 10 miles west in Ward County. In February, Adobe reported an oil discovery, 10 Barstow, drilled between No. 9 and No. 11 (gas wells) in section 34. The well reestablished Cherry Canyon oil production in the Scott field with a potential of 149 bpd of oil and a gor of 1540:1 or gas flow of 230 mcfd. Perforations were from 5827 to 6092 ft. The explanation of the anomaly of an oil well sandwichedmore » between 2 gas wells all producing from the same formation, is that Cherry Canyon consists of lensitic sands, not necessarily connected, that can yield gas and oil in substantially different proportions.« less

  16. General overview of adobe, looking northwest. South wing is at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    General overview of adobe, looking northwest. South wing is at left, and central courtyard, with ovens, at center. (recreation of HABS No. CA-38-P152-3 - Vallejo Adobe, Adobe Road at Casa Grande, Petaluma, Sonoma County, CA

  17. Residential Mercury Contamination in Adobe Brick Homes in Huancavelica, Peru

    PubMed Central

    Hagan, Nicole; Robins, Nicholas; Hsu-Kim, Heileen; Halabi, Susan; Espinoza Gonzales, Ruben Dario; Richter, Daniel deB.; Vandenberg, John

    2013-01-01

    This is the first study of adobe brick contamination anywhere in the world. Huancavelica, Peru is the site of historic cinnabar refining and one of the most mercury (Hg) contaminated urban areas in the world. Over 80% of homes in Huancavelica are constructed with adobe bricks made from Hg contaminated soil. In this study we measured total Hg concentrations in adobe brick, dirt floor, surface dust, and air samples from the interior of 60 adobe brick houses located in four neighborhoods. Concentrations of total Hg in adobe bricks, dirt floors, and surface dust ranged from 8.00 to 1070 µg/g, 3.06 to 926 µg/g, and 0.02 to 9.69 µg/wipe, respectively, with statistically significant differences between the four neighborhoods. Concentrations of Hg in adobe brick and dirt floor samples in Huancavelica were orders of magnitude higher than in Ayacucho, a non-mining town in Peru. A strong correlation exists between total Hg concentrations in adobe bricks and dirt floors which confirms that adobe bricks were being made on-site and not purchased from an off-site source. A strong correlation between surface dust and adobe bricks and dirt floors indicates that walls and floors serve as indoor sources of Hg contamination. Elemental Hg vapor concentrations were below detection (<0.5 µg/m3) in most homes; however in homes with detectable levels, concentrations up to 5.1 µg/m3 were observed. No statistically significant differences in Hg vapor measurements were observed between neighborhoods. This study demonstrates that building materials used widely in developing communities, such as adobe bricks, may be a substantial source of residential Hg exposure in silver or gold refining communities where Hg is produced or used for amalgamation in artisanal gold production. PMID:24040399

  18. 77 FR 34357 - Missile Defense Advisory Committee; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... Missile Defense Advisory Committee, in the following formats: One hard copy with original signature and one electronic copy via email (acceptable file formats: Adobe Acrobat PDF, MS Word or MS PowerPoint...

  19. 76 FR 16736 - Closed Meeting of the Missile Defense Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... Missile Defense Advisory Committee, in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file formats: Adobe Acrobat PDF, MS Word or MS PowerPoint...

  20. 76 FR 47606 - Sport Fishing and Boating Partnership Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... the following formats: One hard copy with original signature, and one electronic copy via e- mail (acceptable file formats are Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or rich text file...

  1. 78 FR 33856 - Sport Fishing and Boating Partnership Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... statements must be supplied to the Council Coordinator in one of the following formats: One hard copy with original signature, and one electronic copy via email (acceptable file formats are Adobe Acrobat PDF, MS...

  2. 77 FR 39252 - Meeting Announcement: North American Wetlands Conservation Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-02

    ... statements must be supplied to the Council Coordinator in both of the following formats: One hard copy with original signature, and one electronic copy via email (acceptable file formats are Adobe Acrobat PDF, MS...

  3. 78 FR 53156 - Sport Fishing and Boating Partnership Council; Teleconference

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ... Council Coordinator in one of the following formats: One hard copy with original signature, and one electronic copy via email (acceptable file formats are Adobe Acrobat PDF, MS Word, MS PowerPoint, or rich...

  4. Three-dimensional portable document format: a simple way to present 3-dimensional data in an electronic publication.

    PubMed

    Danz, Jan C; Katsaros, Christos

    2011-08-01

    Three-dimensional (3D) models of teeth and soft and hard tissues are tessellated surfaces used for diagnosis, treatment planning, appliance fabrication, outcome evaluation, and research. In scientific publications or communications with colleagues, these 3D data are often reduced to 2-dimensional pictures or need special software for visualization. The portable document format (PDF) offers a simple way to interactively display 3D surface data without additional software other than a recent version of Adobe Reader (Adobe, San Jose, Calif). The purposes of this article were to give an example of how 3D data and their analyses can be interactively displayed in 3 dimensions in electronic publications, and to show how they can be exported from any software for diagnostic reports and communications among colleagues. Copyright © 2011 American Association of Orthodontists. Published by Mosby, Inc. All rights reserved.

  5. Geometrical verification system using Adobe Photoshop in radiotherapy.

    PubMed

    Ishiyama, Hiromichi; Suzuki, Koji; Niino, Keiji; Hosoya, Takaaki; Hayakawa, Kazushige

    2005-02-01

    Adobe Photoshop is used worldwide and is useful for comparing portal films with simulation films. It is possible to scan images and then view them simultaneously with this software. The purpose of this study was to assess the accuracy of a geometrical verification system using Adobe Photoshop. We prepared the following two conditions for verification. Under one condition, films were hanged on light boxes, and examiners measured distances between the isocenter on simulation films and that on portal films by adjusting the bony structures. Under the other condition, films were scanned into a computer and displayed using Adobe Photoshop, and examiners measured distances between the isocenter on simulation films and those on portal films by adjusting the bony structures. To obtain control data, lead balls were used as a fiducial point for matching the films accurately. The errors, defined as the differences between the control data and the measurement data, were assessed. Errors of the data obtained using Adobe Photoshop were significantly smaller than those of the data obtained from films on light boxes (p < 0.007). The geometrical verification system using Adobe Photoshop is available on any PC with this software and is useful for improving the accuracy of verification.

  6. 77 FR 60138 - Trinity Adaptive Management Working Group; Public Teleconference/Web-Based Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-02

    ... statements must be supplied to Elizabeth Hadley in one of the following formats: One hard copy with original... file formats are Adobe Acrobat PDF, MS Word, PowerPoint, or rich text file). Registered speakers who...

  7. 76 FR 45783 - Missile Defense Advisory Committee; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ..., in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file formats: Adobe Acrobat PDF, MS Word or MS PowerPoint), and this individual will ensure that...

  8. Military Review: The Professional Journal of the U.S. Army, Volume 90, Number 1, January-February 2000

    DTIC Science & Technology

    2000-02-01

    Bulletin 100-99-5/6 Now available in Adobe Acrobat ( pdf ) format CONTENTS Editorial PDF 2 Korean Conflict: A 50-Year Perspective 3 Task Force Smith...Revisited PDF by Lieutenant Colonel Joseph G.D. Babb, US Army, Retired 14 Harnessing Thunderbolts PDF by Major Kelly C. Jordan, US Army 20 North Korea...and the Bomb PDF by Stanley Weintraub 28 Busting Through PDF by Colonel John F. Antal, US Army 40 Planning for Major Theater Wars: Examining the

  9. 77 FR 37893 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-25

    ... official versions of these documents are the documents published in the Federal Register. Free Internet... telephone (TTY), call the Federal Relay Service (FRS), toll free, at 1- 800-877-8339. Individuals with... Portable Document Format (PDF). To use PDF you must have Adobe Acrobat Reader, which is available free at...

  10. 76 FR 50198 - Committee on Measures of Student Success

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ...: The official version of this document is the document published in the Federal Register. Free Internet... Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the following site... is available free at this site. If you have questions about using PDF, call the U.S. Government...

  11. Two-fold sustainability – Adobe with sawdust as partial sand replacement

    NASA Astrophysics Data System (ADS)

    Jokhio, Gul A.; Syed Mohsin, Sharifah M.; Gul, Yasmeen

    2018-04-01

    Adobe is a material that is economic, environment friendly, and provides better indoor air quality. The material required for the preparation of adobe include clay, sand, and sometimes straw or other organic materials. These materials do not require industrial processing or transportation, however, sand mining has been recently posing a threat to the environment. Therefore, to enhance the existing sustainability of adobe, sand can be partially or fully replaced by other waste materials. This approach will not only solve the problem of excessive sand mining, it will also address the issue of waste management. Sawdust is one such waste material that can be used to partially replace sand in Adobe. This paper presents the results of compressive and flexural test carried out on Adobe samples with partial sand replacement by sawdust. The results show that about 4% sand replacement by volume produces higher compressive strength, whereas the flexural strength reduces with the use of sawdust. However, since flexural strength is not a critical property for adobe, it is concluded that replacing sand with sawdust by about 4% of volume will be beneficial.

  12. MSL: Facilitating automatic and physical analysis of published scientific literature in PDF format.

    PubMed

    Ahmed, Zeeshan; Dandekar, Thomas

    2015-01-01

    Published scientific literature contains millions of figures, including information about the results obtained from different scientific experiments e.g. PCR-ELISA data, microarray analysis, gel electrophoresis, mass spectrometry data, DNA/RNA sequencing, diagnostic imaging (CT/MRI and ultrasound scans), and medicinal imaging like electroencephalography (EEG), magnetoencephalography (MEG), echocardiography  (ECG), positron-emission tomography (PET) images. The importance of biomedical figures has been widely recognized in scientific and medicine communities, as they play a vital role in providing major original data, experimental and computational results in concise form. One major challenge for implementing a system for scientific literature analysis is extracting and analyzing text and figures from published PDF files by physical and logical document analysis. Here we present a product line architecture based bioinformatics tool 'Mining Scientific Literature (MSL)', which supports the extraction of text and images by interpreting all kinds of published PDF files using advanced data mining and image processing techniques. It provides modules for the marginalization of extracted text based on different coordinates and keywords, visualization of extracted figures and extraction of embedded text from all kinds of biological and biomedical figures using applied Optimal Character Recognition (OCR). Moreover, for further analysis and usage, it generates the system's output in different formats including text, PDF, XML and images files. Hence, MSL is an easy to install and use analysis tool to interpret published scientific literature in PDF format.

  13. 77 FR 48974 - Applications for New Awards; Comprehensive Centers Program (CFDA 84.283B); Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-15

    ... version of this document is the document published in the Federal Register. Free Internet access to the... Federal Relay Service (FRS), toll free, at 1- 800-877-8339. SUPPLEMENTARY INFORMATION: We make the... Document Format (PDF). To use PDF you must have Adobe Acrobat Reader, which is available free at the site...

  14. 76 FR 29227 - Funding Down Slate; Indian Education Professional Development Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-20

    ... this document is the document published in the Federal Register. Free Internet access to the official... free, at 1-800-877-8339. Individuals with disabilities can obtain this document in an accessible format... (PDF). To use PDF you must have Adobe Acrobat Reader, which is available free at the site. You may also...

  15. ACHP | Report to the President and Congress, 1996-1997

    Science.gov Websites

    PDF files, you need the Adobe Acrobat Reader. Please visit Adobe to download the free Acrobat Reader . For conversion of PDF to HTML, visit Access Adobe's free conversion service. Updated September 24

  16. ACHP | Citizen's Guide to Section 106 Review

    Science.gov Websites

    print PDF files, you need the Adobe Acrobat Reader. Please visit Adobe to download the free Acrobat Reader. For conversion of PDF to HTML, visit Access Adobe's free conversion service. Return to Top

  17. 77 FR 73969 - International Fisheries; Pacific Tuna Fisheries; Fishing Restrictions in the Eastern Pacific Ocean

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... comments will only be accepted in Microsoft Word or Excel, WordPerfect, or Adobe PDF file formats. Written... membership includes: Belize, Canada, China, Chinese Taipei (Taiwan), Colombia, Costa Rica, Ecuador, El...

  18. Building code challenging the ethics behind adobe architecture in North Cyprus.

    PubMed

    Hurol, Yonca; Yüceer, Hülya; Şahali, Öznem

    2015-04-01

    Adobe masonry is part of the vernacular architecture of Cyprus. Thus, it is possible to use this technology in a meaningful way on the island. On the other hand, although adobe architecture is more sustainable in comparison to other building technologies, the use of it is diminishing in North Cyprus. The application of Turkish building code in the north of the island has created complications in respect of the use of adobe masonry, because this building code demands that reinforced concrete vertical tie-beams are used together with adobe masonry. The use of reinforced concrete elements together with adobe masonry causes problems in relation to the climatic response of the building as well as causing other technical and aesthetic problems. This situation makes the design of adobe masonry complicated and various types of ethical problems also emerge. The objective of this article is to analyse the ethical problems which arise as a consequence of the restrictive character of the building code, by analysing two case studies and conducting an interview with an architect who was involved with the use of adobe masonry in North Cyprus. According to the results of this article there are ethical problems at various levels in the design of both case studies. These problems are connected to the responsibilities of architects in respect of the social benefit, material production, aesthetics and affordability of the architecture as well as presenting distrustful behaviour where the obligations of architects to their clients is concerned.

  19. MSL: Facilitating automatic and physical analysis of published scientific literature in PDF format

    PubMed Central

    Ahmed, Zeeshan; Dandekar, Thomas

    2018-01-01

    Published scientific literature contains millions of figures, including information about the results obtained from different scientific experiments e.g. PCR-ELISA data, microarray analysis, gel electrophoresis, mass spectrometry data, DNA/RNA sequencing, diagnostic imaging (CT/MRI and ultrasound scans), and medicinal imaging like electroencephalography (EEG), magnetoencephalography (MEG), echocardiography  (ECG), positron-emission tomography (PET) images. The importance of biomedical figures has been widely recognized in scientific and medicine communities, as they play a vital role in providing major original data, experimental and computational results in concise form. One major challenge for implementing a system for scientific literature analysis is extracting and analyzing text and figures from published PDF files by physical and logical document analysis. Here we present a product line architecture based bioinformatics tool ‘Mining Scientific Literature (MSL)’, which supports the extraction of text and images by interpreting all kinds of published PDF files using advanced data mining and image processing techniques. It provides modules for the marginalization of extracted text based on different coordinates and keywords, visualization of extracted figures and extraction of embedded text from all kinds of biological and biomedical figures using applied Optimal Character Recognition (OCR). Moreover, for further analysis and usage, it generates the system’s output in different formats including text, PDF, XML and images files. Hence, MSL is an easy to install and use analysis tool to interpret published scientific literature in PDF format. PMID:29721305

  20. 75 FR 46918 - National Assessment Governing Board; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... in the Federal Register. Free Internet access to the official edition of the Federal Register and the... Format (PDF) on the Internet at the following site: http://www.ed.gov/news/fedregister/index.html To use PDF you must have Adobe Acrobat Reader, which is available free at this site. If you have questions...

  1. 77 FR 51709 - International Fisheries; Western and Central Pacific Fisheries for Highly Migratory Species...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... Adobe PDF file formats only. Copies of the RIR and the 2012 supplemental EA prepared under the authority..., Korea, Marshall Islands, Nauru, New Zealand, Niue, Palau, Papua New Guinea, Philippines, Samoa, Solomon...

  2. Shock Response of Lightweight Adobe Masonry

    NASA Astrophysics Data System (ADS)

    Sauer, C.; Bagusat, F.; Heine, A.; Riedel, W.

    2018-06-01

    The behavior of a low density and low-strength building material under shock loading is investigated. The considered material is lightweight adobe masonry characterized by a density of 1.2 g/cm3 and a quasi-static uniaxial compressive strength of 2.8 MPa. Planar-plate-impact (PPI) tests with velocities in between 295 and 950 m/s are performed in order to obtain Hugoniot data and to derive parameters for an equation of state (EOS) that captures the occurring phenomenology of porous compaction and subsequent unloading. The resulting EOS description is validated by comparing the experimental free surface velocity time curves with those obtained by numerical simulations of the performed PPI tests. The non-linear compression behavior, including the pore compaction mechanism, constitutes a main ingredient for modelling the response of adobe to blast and high-velocity impact loading. We hence present a modeling approach for lightweight adobe which can be applied to such high rate loading scenarios in future studies. In general, this work shows that PPI tests on lightweight and low-strength geological materials can be used to extract Hugoniot data despite significant material inhomogeneity. Furthermore, we demonstrate that a homogenous material model is able to numerically describe such a material under shock compression and release with a reasonable accuracy.

  3. Shock Response of Lightweight Adobe Masonry

    NASA Astrophysics Data System (ADS)

    Sauer, C.; Bagusat, F.; Heine, A.; Riedel, W.

    2018-04-01

    The behavior of a low density and low-strength building material under shock loading is investigated. The considered material is lightweight adobe masonry characterized by a density of 1.2 g/cm3 and a quasi-static uniaxial compressive strength of 2.8 MPa. Planar-plate-impact (PPI) tests with velocities in between 295 and 950 m/s are performed in order to obtain Hugoniot data and to derive parameters for an equation of state (EOS) that captures the occurring phenomenology of porous compaction and subsequent unloading. The resulting EOS description is validated by comparing the experimental free surface velocity time curves with those obtained by numerical simulations of the performed PPI tests. The non-linear compression behavior, including the pore compaction mechanism, constitutes a main ingredient for modelling the response of adobe to blast and high-velocity impact loading. We hence present a modeling approach for lightweight adobe which can be applied to such high rate loading scenarios in future studies. In general, this work shows that PPI tests on lightweight and low-strength geological materials can be used to extract Hugoniot data despite significant material inhomogeneity. Furthermore, we demonstrate that a homogenous material model is able to numerically describe such a material under shock compression and release with a reasonable accuracy.

  4. 76 FR 10405 - Federal Copyright Protection of Sound Recordings Fixed Before February 15, 1972

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... file in either the Adobe Portable Document File (PDF) format that contains searchable, accessible text (not an image); Microsoft Word; WordPerfect; Rich Text Format (RTF); or ASCII text file format (not a..., comments may be delivered in hard copy. If hand delivered by a private party, an original [[Page 10406...

  5. 76 FR 75898 - Sport Fishing and Boating Partnership Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-05

    ... following formats: One hard copy with original signature, and one electronic copy via email (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Please submit your statement to Douglas Hobbs, Council Coordinator (see FOR FURTHER...

  6. Web Standard: PDF - When to Use, Document Metadata, PDF Sections

    EPA Pesticide Factsheets

    PDF files provide some benefits when used appropriately. PDF files should not be used for short documents ( 5 pages) unless retaining the format for printing is important. PDFs should have internal file metadata and meet section 508 standards.

  7. 76 FR 32198 - Science Advisory Board Staff Office Notification of a Joint Public Meeting of the Chartered...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ... meeting. Written statements should be supplied to the DFO in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, MS Word, WordPerfect, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are...

  8. 76 FR 4346 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... their consideration. Written statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/ Windows 98/2000/XP format...

  9. 75 FR 80048 - Science Advisory Board Staff Office; Notification of an Upcoming Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-21

    ... be supplied to the DFO in the following formats: One hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/ Windows 98/2000/XP format). Submitters are requested to provide two...

  10. 75 FR 37793 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-30

    ... supplied to the DFO in the following formats: One hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/ Windows 98/2000/XP format). Submitters are requested to provide two versions...

  11. 76 FR 11245 - Science Advisory Board Staff Office; Notification of Two Public Teleconferences of the Science...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... their consideration. Written statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/ Windows 98/2000/XP format...

  12. Adobe acrobat: an alternative electronic teaching file construction methodology independent of HTML restrictions.

    PubMed

    Katzman, G L

    2001-03-01

    The goal of the project was to create a method by which an in-house digital teaching file could be constructed that was simple, inexpensive, independent of hypertext markup language (HTML) restrictions, and appears identical on multiple platforms. To accomplish this, Microsoft PowerPoint and Adobe Acrobat were used in succession to assemble digital teaching files in the Acrobat portable document file format. They were then verified to appear identically on computers running Windows, Macintosh Operating Systems (OS), and the Silicon Graphics Unix-based OS as either a free-standing file using Acrobat Reader software or from within a browser window using the Acrobat browser plug-in. This latter display method yields a file viewed through a browser window, yet remains independent of underlying HTML restrictions, which may confer an advantage over simple HTML teaching file construction. Thus, a hybrid of HTML-distributed Adobe Acrobat generated WWW documents may be a viable alternative for digital teaching file construction and distribution.

  13. 75 FR 4816 - Science Advisory Board Staff Office; Notification of Two Public Teleconferences of the Chartered...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are asked to provide...

  14. 75 FR 52940 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Chartered Science...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... should be supplied to the DFO in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, MS Word, WordPerfect, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are asked to provide electronic...

  15. 75 FR 1381 - Science Advisory Board Staff Office; Notification of a Public Teleconference of the Clean Air...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... supplied to the DFO in the following formats: one hard copy with original signature and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, MS Word, WordPerfect, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are asked to provide versions of each...

  16. 76 FR 16769 - Science Advisory Board Staff Office; Notification of a Public Meeting of the Science Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... statements should be supplied to the DFO in the following formats: One hard copy with original signature and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are requested to provide...

  17. 75 FR 62386 - Science Advisory Board Staff Office; Notification of Two Public Teleconferences of the Science...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    .... Written statements should be supplied to the DFO in the following formats: one hard copy with original signature, and one electronic copy via e-mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). Submitters are asked to...

  18. 75 FR 47624 - Sport Fishing and Boating Partnership Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-06

    ... Coordinator in both of the following formats: One hard copy with original signature, and one electronic copy via e- mail (acceptable file format: Adobe Acrobat PDF, WordPerfect, MS Word, MS PowerPoint, or Rich Text files in IBM-PC/Windows 98/2000/XP format). In order to attend this meeting, you must register by...

  19. 75 FR 3212 - Office of Elementary and Secondary Education; College Assistance Migrant Program (CAMP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... Federal Register. Free Internet access to the official edition of the Federal Register and the Code of... (FRS), toll free, at 1-800-877-8339. Accessible Format: Individuals with disabilities can obtain this... published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the...

  20. 75 FR 3216 - Office of Elementary and Secondary Education; High School Equivalency Program (HEP)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... Federal Register. Free Internet access to the official edition of the Federal Register and the Code of... (FRS), toll free, at 1-800-877-8339. Accessible Format: Individuals with disabilities can obtain this... published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the...

  1. An LES-PBE-PDF approach for modeling particle formation in turbulent reacting flows

    NASA Astrophysics Data System (ADS)

    Sewerin, Fabian; Rigopoulos, Stelios

    2017-10-01

    Many chemical and environmental processes involve the formation of a polydispersed particulate phase in a turbulent carrier flow. Frequently, the immersed particles are characterized by an intrinsic property such as the particle size, and the distribution of this property across a sample population is taken as an indicator for the quality of the particulate product or its environmental impact. In the present article, we propose a comprehensive model and an efficient numerical solution scheme for predicting the evolution of the property distribution associated with a polydispersed particulate phase forming in a turbulent reacting flow. Here, the particulate phase is described in terms of the particle number density whose evolution in both physical and particle property space is governed by the population balance equation (PBE). Based on the concept of large eddy simulation (LES), we augment the existing LES-transported probability density function (PDF) approach for fluid phase scalars by the particle number density and obtain a modeled evolution equation for the filtered PDF associated with the instantaneous fluid composition and particle property distribution. This LES-PBE-PDF approach allows us to predict the LES-filtered fluid composition and particle property distribution at each spatial location and point in time without any restriction on the chemical or particle formation kinetics. In view of a numerical solution, we apply the method of Eulerian stochastic fields, invoking an explicit adaptive grid technique in order to discretize the stochastic field equation for the number density in particle property space. In this way, sharp moving features of the particle property distribution can be accurately resolved at a significantly reduced computational cost. As a test case, we consider the condensation of an aerosol in a developed turbulent mixing layer. Our investigation not only demonstrates the predictive capabilities of the LES-PBE-PDF model but also

  2. 78 FR 25749 - Submission of New Drug Application/Abbreviated New Drug Application Field Alert Reports: Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-02

    ... language)-enabled Adobe PDF form, Form FDA 3331--Automated to submit new drug application (NDA) and...-enabled Adobe PDF form, Form FDA 3331--Automated, will be available for piloting between May 1, 2013, and... modernize the FAR submission and review pathway using an XML-enabled PDF form to enable integration with...

  3. Viewing Files | Smokefree 60+

    Cancer.gov

    In addition to standard HTML webpages, our website contains files in other formats. You may need additional software or browser plug-ins to view some of these files. The following list shows each format along with links to the corresponding freely available plug-ins or viewers. Documents  Adobe Acrobat Reader (.pdf)

  4. Low cost passive solar adobe house

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1981-12-21

    A brief description, photographs, and cost breakdown of a hybrid direct-gain passive solar adobe house constructed in the City of El Paso, Texas. The 3-panel active solar domestic hot water system acts as a back-up to the direct gain passive system.

  5. Visualization on triangle concept using Adobe Flash Professional SC6

    NASA Astrophysics Data System (ADS)

    Sagita, Laela; Ratih Kusumarini, Adha

    2017-12-01

    The purpose of this paper is to develop teaching aids using Adobe Flash Professional CS6 emphasize on Triangle concept. A new alternative way to deliver a basic concept in geometry with visualization is software Adobe Flash Professional CS 6. Research method is research and development with 5 phase of Ploom’s model, namely (1) preliminary, (2) design, (3) realization/ construction, (4) test, evaluation and revision, and 5) implementation. The results showed that teaching aids was valid, practice, and effective. Validity: expert judgement for material score is 3.95 and media expert judgement produce an average score of 3,2, both in the category are valid. Practically: the average of questionnaire response is 4,04 (good). Effectiveness: n-gain test value is 0,36 (medium). It concluded that developed of teaching aids using Adobe Flash CS6 on triangle can improve student achievement.

  6. Numerical Simulation Of Cratering Effects In Adobe

    DTIC Science & Technology

    2013-07-01

    DEVELOPMENT OF MATERIAL PARAMETERS .........................................................7 PROBLEM SETUP...37 PARAMETER ADJUSTMENTS ......................................................................................38 GLOSSARY...dependent yield surface with the Geological Yield Surface (GEO) modeled in CTH using well characterized adobe. By identifying key parameters that

  7. WEBTAS Software Life Cycle Development

    DTIC Science & Technology

    2006-09-01

    may be published in both html and pdf formats via menu selection. Adobe® FrameMaker ® 7.1 and Quadralay Corporation WebWorks® Professional 2003...X X WebTAS 2.5.3 ISAM X X WebTAS 2.5.3 Domain Editor Guide X X 13 The backbone of the ISS publishing environment consists of Adobe® FrameMaker ...and WebWorks® Publisher Professional 2003. FrameMaker ® provides an enterprise-class authoring and publishing solution that combines the

  8. Climate Prediction Center: ENSO Diagnostic Discussion

    Science.gov Websites

    : English Version Spanish Version Adobe PDF Reader (Click icon for Adobe PDF Reader) Word: English Version Spanish Version MS Word Viewer (Click icon for MS Word Viewer) HTML: English Version Spanish Version NOAA

  9. Compressive and Flexural Tests on Adobe Samples Reinforced with Wire Mesh

    NASA Astrophysics Data System (ADS)

    Jokhio, G. A.; Al-Tawil, Y. M. Y.; Syed Mohsin, S. M.; Gul, Y.; Ramli, N. I.

    2018-03-01

    Adobe is an economical, naturally available, and environment friendly construction material that offers excellent thermal and sound insulations as well as indoor air quality. It is important to understand and enhance the mechanical properties of this material, where a high degree of variation is reported in the literature owing to lack of research and standardization in this field. The present paper focuses first on the understanding of mechanical behaviour of adobe subjected to compressive stresses as well as flexure and then on enhancing the same with the help of steel wire mesh as reinforcement. A total of 22 samples were tested out of which, 12 cube samples were tested for compressive strength, whereas 10 beams samples were tested for modulus of rupture. Half of the samples in each category were control samples i.e. without wire mesh reinforcement, whereas the remaining half were reinforced with a single layer of wire mesh per sample. It has been found that the compressive strength of adobe increases by about 43% after adding a single layer of wire mesh reinforcement. The flexural response of adobe has also shown improvement with the addition of wire mesh reinforcement.

  10. Techniques on semiautomatic segmentation using the Adobe Photoshop

    NASA Astrophysics Data System (ADS)

    Park, Jin Seo; Chung, Min Suk; Hwang, Sung Bae

    2005-04-01

    The purpose of this research is to enable anybody to semiautomatically segment the anatomical structures in the MRIs, CTs, and other medical images on the personal computer. The segmented images are used for making three-dimensional images, which are helpful in medical education and research. To achieve this purpose, the following trials were performed. The entire body of a volunteer was MR scanned to make 557 MRIs, which were transferred to a personal computer. On Adobe Photoshop, contours of 19 anatomical structures in the MRIs were semiautomatically drawn using MAGNETIC LASSO TOOL; successively, manually corrected using either LASSO TOOL or DIRECT SELECTION TOOL to make 557 segmented images. In a likewise manner, 11 anatomical structures in the 8,500 anatomcial images were segmented. Also, 12 brain and 10 heart anatomical structures in anatomical images were segmented. Proper segmentation was verified by making and examining the coronal, sagittal, and three-dimensional images from the segmented images. During semiautomatic segmentation on Adobe Photoshop, suitable algorithm could be used, the extent of automatization could be regulated, convenient user interface could be used, and software bugs rarely occurred. The techniques of semiautomatic segmentation using Adobe Photoshop are expected to be widely used for segmentation of the anatomical structures in various medical images.

  11. Adobe photoshop quantification (PSQ) rather than point-counting: A rapid and precise method for quantifying rock textural data and porosities

    NASA Astrophysics Data System (ADS)

    Zhang, Xuefeng; Liu, Bo; Wang, Jieqiong; Zhang, Zhe; Shi, Kaibo; Wu, Shuanglin

    2014-08-01

    Commonly used petrological quantification methods are visual estimation, counting, and image analyses. However, in this article, an Adobe Photoshop-based analyzing method (PSQ) is recommended for quantifying the rock textural data and porosities. Adobe Photoshop system provides versatile abilities in selecting an area of interest and the pixel number of a selection could be read and used to calculate its area percentage. Therefore, Adobe Photoshop could be used to rapidly quantify textural components, such as content of grains, cements, and porosities including total porosities and different genetic type porosities. This method was named as Adobe Photoshop Quantification (PSQ). The workflow of the PSQ method was introduced with the oolitic dolomite samples from the Triassic Feixianguan Formation, Northeastern Sichuan Basin, China, for example. And the method was tested by comparing with the Folk's and Shvetsov's "standard" diagrams. In both cases, there is a close agreement between the "standard" percentages and those determined by the PSQ method with really small counting errors and operator errors, small standard deviations and high confidence levels. The porosities quantified by PSQ were evaluated against those determined by the whole rock helium gas expansion method to test the specimen errors. Results have shown that the porosities quantified by the PSQ are well correlated to the porosities determined by the conventional helium gas expansion method. Generally small discrepancies (mostly ranging from -3% to 3%) are caused by microporosities which would cause systematic underestimation of 2% and/or by macroporosities causing underestimation or overestimation in different cases. Adobe Photoshop could be used to quantify rock textural components and porosities. This method has been tested to be precise and accurate. It is time saving compared with usual methods.

  12. Digital Imaging: An Adobe Photoshop Course

    ERIC Educational Resources Information Center

    Cobb, Kristine

    2007-01-01

    This article introduces digital imaging, an Adobe Photoshop course at Shrewsbury High School in Shrewsbury, Massachusetts. Students are able to earn art credits to graduate by successfully completing the course. Digital imaging must cover art criteria as well as technical skills. The course begins with tutorials created by the instructor and other…

  13. 77 FR 53164 - Magnuson-Stevens Fishery Conservation and Management Act Provisions; Fisheries of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... Microsoft Word, Microsoft Excel, WordPerfect, or Adobe PDF file formats only. FOR FURTHER INFORMATION...). The closure was implemented based on advice from the U.S. Food and Drug Administration (FDA) after... Management Plan (FMP). Since the implementation of the closure, NOAA's National Ocean Service has provided...

  14. 76 FR 47492 - Fisheries of the Northeastern United States; Atlantic Mackerel, Squid, and Butterfish Fishery...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    ... Adobe PDF file formats only. FOR FURTHER INFORMATION CONTACT: Aja Szumylo, Fishery Policy Analyst, (978...: (1) The emergency results from recent, unforeseen events or recently discovered circumstances; (2..., NOAA, finds good cause under section 553(b)(B) of the Administrative Procedure Act (APA) that it is...

  15. A method for removing adobe-type manure from hides using an oxidizing agent

    USDA-ARS?s Scientific Manuscript database

    Adobe-type (hardened) manure attached to bovine hair is a major source of meat contamination, hide quality deterioration, and devalued leather products. Therefore, it is important to develop cleaning solutions that can rapidly remove adobe-type manure to improve the quality of hides delivered to tan...

  16. [Practical experience about the compatibility of PDF converter in ECG information system].

    PubMed

    Yang, Gang; Lu, Weishi; Zhou, Jiacheng

    2009-11-01

    To find a way to view ECG from different manufacturers in electrocardiogram information system. Different format ECG data were transmitted to ECG center by different ways. Corresponding analysis software was used to make the diagnosis reports in the center. Then we use PDF convert to change all ECG reports into PDF format. The electrocardiogram information system manage these PDF format ECG data for clinic user. The ECG reports form several major ECG manufacturers were transformed to PDF format successfully. In the electrocardiogram information system it is freely to view the ECG figure. PDF format ECG report is a practicable way to solve the compatibility problem in electrocardiogram information system.

  17. 75 FR 52921 - Fisheries in the Western Pacific; Hawaii Bottomfish and Seamount Groundfish; Management Measures...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... anonymous). Attachments to electronic comments will be accepted in Microsoft Word or Excel, WordPerfect, or Adobe PDF file formats only. Amendment 2 to the Fishery Ecosystem Plan for the Hawaiian Archipelago....gpoaccess.gov/fr . Fishing for pelagic armorhead is managed under the Fishery Ecosystem Plan for the...

  18. 77 FR 72788 - Copyright Office Fees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-06

    ... Adobe Portable Document File (PDF) format that contains searchable, accessible text (not an image... processing such statements and associated royalty payments was funded solely by the royalty fees collected... Title 17 that permits the Office to apportion up to 50 percent of the cost of processing the SOAs and...

  19. 76 FR 13887 - Fisheries of the Northeastern United States; Atlantic Mackerel, Squid, and Butterfish (MSB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-15

    ... comments in Microsoft Word, Excel, WordPerfect, or Adobe PDF file formats only. FOR FURTHER INFORMATION... butterfish stock was overfished. The Mid-Atlantic Fishery Management Council (Council) developed Amendment 10 to the FMP in response to SAW 38; Amendment 10 enacted a rebuilding program for butterfish, as well...

  20. 77 FR 34334 - Western Pacific Pelagic Fisheries; Revised Limits on Sea Turtle Interactions in the Hawaii...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ...-set longline fishery. The proposed rule would implement terms and conditions of the current biological..., WordPerfect, or Adobe PDF file formats only. A biological opinion issued under the Endangered Species... Network, et al., v. Department of Commerce, et al., and Hawaii Longline Association, Civil No. 09-00598...

  1. OHD/SRC - Science Research and Collaboration

    Science.gov Websites

    Collaborative Research Program Current Announcement Past Announcements Collaborative Research Projects General Science Plan in Adobe pdf format. OHD Seminars. Recordings of past OHD seminars are posted on this page . The Current Announcement and Past Announcement sections display the text of the respective

  2. 78 FR 66675 - Endangered and Threatened Wildlife; 90-Day Finding on a Petition To List Multiple Species of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-06

    ... to electronic comments will be accepted in Microsoft Word, Excel, or Adobe PDF file formats only... this document, identified by the code NOAA-NMFS-2013-0150, by any of the following methods: Electronic Submissions: Submit all electronic comments via the Federal eRulemaking Portal. Go to www.regulations.gov...

  3. [Use of Adobe Photoshop software in medical criminology].

    PubMed

    Nikitin, S A; Demidov, I V

    2000-01-01

    Describes the method of comparative analysis of various objects in practical medical criminology and making of high-quality photographs with the use of Adobe Photoshop software. Options of the software needed for expert evaluations are enumerated.

  4. Processed Thematic Mapper Satellite Imagery for Selected Areas within the U.S.-Mexico Borderlands

    USGS Publications Warehouse

    Dohrenwend, John C.; Gray, Floyd; Miller, Robert J.

    2000-01-01

    The study is summarized in the Adobe Acrobat Portable Document Format (PDF) file OF00-309.PDF. This publication also contain satellite full-scene images of selected areas along the U.S.-Mexico border. These images are presented as high-resolution images in jpeg format (IMAGES). The folder LOCATIONS in contains TIFF images showing exact positions of easily-identified reference locations for each of the Landsat TM scenes located at least partly within the U.S. A reference location table (BDRLOCS.DOC in MS Word format) lists the latitude and longitude of each reference location with a nominal precision of 0.001 minute of arc

  5. ACHP | Heritage Tourism and the Federal Government: Summit I Proceedings

    Science.gov Websites

    Adobe Acrobat Reader. Please visit Adobe to download the free Acrobat Reader. For conversion of PDF to HTML, visit Access Adobe's free conversion service. Updated September 24, 2011 Return to Top

  6. 76 FR 5363 - Intent To Compromise Claim Against the State of Oklahoma Department of Education

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-31

    ... must have Adobe Acrobat Reader, which is available free at this site. Note: The official version of this document is the document published in the Federal Register. Free Internet access to the official... Document Format (PDF) on the Internet at the following site: http://frwebgate.access.gpo.gov/cgi-bin...

  7. 76 FR 22350 - Fisheries of the Northeastern United States; Recreational Management Measures for the Summer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ..., Excel, WordPerfect, or Adobe PDF file formats only. Copies of the proposed scup increase Supplement... is generically described in the following section. All meetings are open to the public and the... open season of June 6 through September 26, which are the status quo measures; and, for black sea bass...

  8. 75 FR 45085 - Fisheries in the Western Pacific; Bottomfish and Seamount Groundfish Fisheries; 2010-11 Main...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... would be caught, but because the 2009-10 fishery took less than the TAC, the associated risk of... will be accepted in Microsoft Word or Excel, WordPerfect, or Adobe PDF file formats only. A... other information, and taking into account the associated risk of overfishing. The Deep 7 bottomfish are...

  9. 76 FR 32025 - Endangered and Threatened Wildlife and Plants: Proposed Rulemaking To Revise Critical Habitat for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-02

    ...-BA81 by any one of the following methods: Electronic Submissions: Federal eRulemaking Portal: http... required fields if you wish to remain anonymous). Attachments to electronic comments will be accepted in Microsoft Word, Excel, WordPerfect, or Adobe PDF file formats only. The petition, 90-day finding, 12-month...

  10. ACHP | Federal Stewardship Report

    Science.gov Websites

    files, you need the Adobe Acrobat Reader. Please visit Adobe to download the free Acrobat Reader. For conversion of PDF to HTML, visit Access Adobe's free conversion service. Updated September 2, 2003 Return to

  11. 75 FR 39220 - Charter Schools Program (CSP) Grants for Replication and Expansion of High-Quality Charter Schools

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... Federal Register. Free Internet access to the official edition of the Federal Register and the Code of... telecommunications device for the deaf, call the Federal Relay Service, toll free, at 1-800-877-8339. Electronic... published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the...

  12. 75 FR 36066 - Promise Neighborhoods Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-24

    ... official version of this document is the document published in the Federal Register. Free Internet access... Federal Relay Service, toll free, at 1-800-877-8339. Electronic Access to This Document: You can view this... Adobe Portable Document Format (PDF) on the Internet at the following site: http://www.ed.gov/news...

  13. 75 FR 25221 - Notice Extending the Deadline Date for Transmittal of Applications and the Deadline Date for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... published in the Federal Register. Free Internet access to the official edition of the Federal Register and... telecommunications device for the deaf (TDD), call the Federal Relay Service (FRS), toll free, at 1-800-877-8339... Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the following site...

  14. 75 FR 3448 - Office of Innovation and Improvement; Notice Extending the Deadline Date for Transmittal of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... published in the Federal Register. Free Internet access to the official edition of the Federal Register and... telecommunications device, you may call the Federal Relay Service (FRS), toll free, at 1-800-877-8339. Individuals... Department published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet...

  15. 75 FR 38510 - Office of Special Education and Rehabilitative Services; Personnel Development to Improve...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... published in the Federal Register. Free Internet access to the official edition of the Federal Register and.... Electronic Access to This Document: You can view this document, as well as all other documents of this Department published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet...

  16. 75 FR 28594 - Ready-to-Learn Television Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... Federal Register. Free Internet access to the official edition of the Federal Register and the Code of... Access to This Document: You can view this document, as well as all other documents of this Department published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the...

  17. 75 FR 21614 - Investing in Innovation Fund

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... published in the Federal Register. Free Internet access to the official edition of the Federal Register and... section 307 of division D of the Consolidated Appropriations Act, 2010, Pub. L. 111-117. Electronic Access... published in the Federal Register, in text or Adobe Portable Document Format (PDF) on the Internet at the...

  18. 75 FR 18170 - Ready-to-Learn Television Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... official version of this document is the document published in the Federal Register. Free Internet access... Federal Relay Service, toll free, at 1-800-877-8339. Electronic Access to This Document: You can view this... Adobe Portable Document Format (PDF) on the Internet at the following site: http://www.ed.gov/news...

  19. Statistical Analysis of Compressive and Flexural Test Results on the Sustainable Adobe Reinforced with Steel Wire Mesh

    NASA Astrophysics Data System (ADS)

    Jokhio, Gul A.; Syed Mohsin, Sharifah M.; Gul, Yasmeen

    2018-04-01

    It has been established that Adobe provides, in addition to being sustainable and economic, a better indoor air quality without spending extensive amounts of energy as opposed to the modern synthetic materials. The material, however, suffers from weak structural behaviour when subjected to adverse loading conditions. A wide range of mechanical properties has been reported in literature owing to lack of research and standardization. The present paper presents the statistical analysis of the results that were obtained through compressive and flexural tests on Adobe samples. Adobe specimens with and without wire mesh reinforcement were tested and the results were reported. The statistical analysis of these results presents an interesting read. It has been found that the compressive strength of adobe increases by about 43% after adding a single layer of wire mesh reinforcement. This increase is statistically significant. The flexural response of Adobe has also shown improvement with the addition of wire mesh reinforcement, however, the statistical significance of the same cannot be established.

  20. Portable document format file showing the surface models of cadaver whole body.

    PubMed

    Shin, Dong Sun; Chung, Min Suk; Park, Jin Seo; Park, Hyung Seon; Lee, Sangho; Moon, Young Lae; Jang, Hae Gwon

    2012-08-01

    In the Visible Korean project, 642 three-dimensional (3D) surface models have been built from the sectioned images of a male cadaver. It was recently discovered that popular PDF file enables users to approach the numerous surface models conveniently on Adobe Reader. Purpose of this study was to present a PDF file including systematized surface models of human body as the beneficial contents. To achieve the purpose, fitting software packages were employed in accordance with the procedures. Two-dimensional (2D) surface models including the original sectioned images were embedded into the 3D surface models. The surface models were categorized into systems and then groups. The adjusted surface models were inserted to a PDF file, where relevant multimedia data were added. The finalized PDF file containing comprehensive data of a whole body could be explored in varying manners. The PDF file, downloadable freely from the homepage (http://anatomy.co.kr), is expected to be used as a satisfactory self-learning tool of anatomy. Raw data of the surface models can be extracted from the PDF file and employed for various simulations for clinical practice. The technique to organize the surface models will be applied to manufacture of other PDF files containing various multimedia contents.

  1. What you see is not what you get in the PDF document format.

    PubMed

    Dahl, Mads R; Simonsen, Eivind O; Høyer, Christian B

    2011-03-01

    The sharing and storage of scientific knowledge, information and data are today mainly in digitized form, which will become the predominant means of communicating scientific work in the future. One of the best-established formats is the open standard of PDF (Portable Document Format), which is renowned for its flexibility and stability. In this article, we expose a major flaw in the format with respect to the security of confidential information, such that even organizations responsible for safeguarding and setting the standards for data management were unintentionally revealing confidential patient data. By collecting and analysing a random sample of files from a health informatics organization, we demonstrate the extent of the problem and determine its cause by code analysis of an example. In conclusion, we suggest the development of a knowledge-sharing format that does not demand expert skills for safe usage: WYSIWYS (What You See Is What You Store). © The Author(s) 2011.

  2. GenomeVx: simple web-based creation of editable circular chromosome maps.

    PubMed

    Conant, Gavin C; Wolfe, Kenneth H

    2008-03-15

    We describe GenomeVx, a web-based tool for making editable, publication-quality, maps of mitochondrial and chloroplast genomes and of large plasmids. These maps show the location of genes and chromosomal features as well as a position scale. The program takes as input either raw feature positions or GenBank records. In the latter case, features are automatically extracted and colored, an example of which is given. Output is in the Adobe Portable Document Format (PDF) and can be edited by programs such as Adobe Illustrator. GenomeVx is available at http://wolfe.gen.tcd.ie/GenomeVx

  3. Application of adobe flash media to optimize jigsaw learning model on geometry material

    NASA Astrophysics Data System (ADS)

    Imam, P.; Imam, S.; Ikrar, P.

    2018-05-01

    This study aims to determine and describe the effectiveness of the application of adobe flash media for jigsaw learning model on geometry material. In this study, the modified jigsaw learning with adobe flash media is called jigsaw-flash model. This research was conducted in Surakarta. The research method used is mix method research with exploratory sequential strategy. The results of this study indicate that students feel more comfortable and interested in studying geometry material taught by jigsaw-flash model. In addition, students taught using the jigsaw-flash model are more active and motivated than the students who were taught using ordinary jigsaw models. This shows that the use of the jigsaw-flash model can increase student participation and motivation. It can be concluded that the adobe flash media can be used as a solution to reduce the level of student abstraction in learning mathematics.

  4. Collecting Response Times using Amazon Mechanical Turk and Adobe Flash

    PubMed Central

    Simcox, Travis; Fiez, Julie A.

    2017-01-01

    Crowdsourcing systems like Amazon's Mechanical Turk (AMT) allow data to be collected from a large sample of people in a short amount of time. This use has garnered considerable interest from behavioral scientists. So far, most experiments conducted on AMT have focused on survey-type instruments because of difficulties inherent in running many experimental paradigms over the Internet. This article investigated the viability of presenting stimuli and collecting response times using Adobe Flash to run ActionScript 3 code in conjunction with AMT. First, the timing properties of Adobe Flash were investigated using a phototransistor and two desktop computers running under several conditions mimicking those that may be present in research using AMT. This experiment revealed some strengths and weaknesses of the timing capabilities of this method. Next, a flanker task and a lexical decision task implemented in Adobe Flash were administered to participants recruited with AMT. The expected effects in these tasks were replicated. Power analyses were conducted to describe the number of participants needed to replicate these effects. A questionnaire was used to investigate previously undescribed computer use habits of 100 participants on AMT. We conclude that a Flash program in conjunction with AMT can be successfully used for running many experimental paradigms that rely on response times, although experimenters must understand the limitations of the method. PMID:23670340

  5. Technical report on semiautomatic segmentation using the Adobe Photoshop.

    PubMed

    Park, Jin Seo; Chung, Min Suk; Hwang, Sung Bae; Lee, Yong Sook; Har, Dong-Hwan

    2005-12-01

    The purpose of this research is to enable users to semiautomatically segment the anatomical structures in magnetic resonance images (MRIs), computerized tomographs (CTs), and other medical images on a personal computer. The segmented images are used for making 3D images, which are helpful to medical education and research. To achieve this purpose, the following trials were performed. The entire body of a volunteer was scanned to make 557 MRIs. On Adobe Photoshop, contours of 19 anatomical structures in the MRIs were semiautomatically drawn using MAGNETIC LASSO TOOL and manually corrected using either LASSO TOOL or DIRECT SELECTION TOOL to make 557 segmented images. In a similar manner, 13 anatomical structures in 8,590 anatomical images were segmented. Proper segmentation was verified by making 3D images from the segmented images. Semiautomatic segmentation using Adobe Photoshop is expected to be widely used for segmentation of anatomical structures in various medical images.

  6. PDF for Healthcare and Child Health Data Forms.

    PubMed

    Zuckerman, Alan E; Schneider, Joseph H; Miller, Ken

    2008-11-06

    PDF-H is a new best practices standard that uses XFA forms and embedded JavaScript to combine PDF forms with XML data. Preliminary experience with AAP child health forms shows that the combination of PDF with XML is a more effective method to visualize familiar data on paper and the web than the traditional use of XML and XSLT. Both PDF-H and HL7 Clinical Document Architecture can co-exist using the same data for different display formats.

  7. Simplified generation of biomedical 3D surface model data for embedding into 3D portable document format (PDF) files for publication and education.

    PubMed

    Newe, Axel; Ganslandt, Thomas

    2013-01-01

    The usefulness of the 3D Portable Document Format (PDF) for clinical, educational, and research purposes has recently been shown. However, the lack of a simple tool for converting biomedical data into the model data in the necessary Universal 3D (U3D) file format is a drawback for the broad acceptance of this new technology. A new module for the image processing and rapid prototyping framework MeVisLab does not only provide a platform-independent possibility to create surface meshes out of biomedical/DICOM and other data and to export them into U3D--it also lets the user add meta data to these meshes to predefine colors and names that can be processed by a PDF authoring software while generating 3D PDF files. Furthermore, the source code of the respective module is available and well documented so that it can easily be modified for own purposes.

  8. Shock compression of simulated adobe

    NASA Astrophysics Data System (ADS)

    Braithwaite, C. H.; Church, P. D.; Gould, P. J.; Stewart, B.; Jardine, A. P.

    2017-01-01

    A series of plate impact experiments were conducted to investigate the shock response of a simulant for adobe, a traditional form of building material widely used around the world. Air dried bricks were sourced from the London brick company, dry machined and impacted at a range of velocities in a single stage gas gun. The shock Hugoniot was determined (Us =2.26up+0.37) as well as release information. The material was found to behave in a manner which was similar to that of loose sand and considerably less stiff than a weak porous sandstone. The effect of any cementing of the grains was examined by shocking powdered samples contained within a cell arrangement.

  9. Rehabilitation of adobe buildings. Understanding different materials from Portugal

    NASA Astrophysics Data System (ADS)

    Costa, Cristiana; Rocha, Fernando; Velosa, Ana

    2016-04-01

    Earth construction is the oldest building material known, with documented cases of the use of earth bricks since Mesopotamia around 10 000 BC (Heathcote, 1995). The earth construction exists throughout the majority of the world in different cultures, and for some countries, nowadays it continues to be the main process of construction (Vega et al, 2011). Around 30% of the world's population lives in buildings made of earth materials. Earthen construction is an environmentally friendly technique with a social and cultural contribution; this advantage is increased when this type of construction is applied in developing countries where the material costs counterbalance with labour costs, and where other materials and techniques cannot be available (Ciancio et al, 2013). Studies of materials characterization are required in order to understand the composition and specific properties of the earth buildings, their heterogeneity and their degradation mechanisms. Some adobes from different buildings, ages and regions of Portugal were collected in order to characterize them (mineralogically, chemically and physically). It was possible to understand the composition of these materials and their differences. Main minerals are quartz, feldspars, calcite and phyllosilicates (mica and kaolinite). The mechanical behaviour of these materials isn't the best, but it is possible to improve it with some simple and cheap natural additives (kaolinitic soils). The characterization of these materials allows us to understand the differences between the materials from the different regions (controlled by locally available raw materials). Understanding these materials, and their properties, it is possible to formulate new ones for repair, conservation and rehabilitation works. The adobe bricks are an alternative of kiln baked bricks which has several advantages and one of the most important is that these materials are recyclable. Adobes are an excellent option for building rehabilitation, if

  10. Shock Compression of Simulated Adobe

    NASA Astrophysics Data System (ADS)

    Braithwaite, C. H.; Church, P. D.; Gould, P. J.; Stewart, B.; Jardine, A. P.

    2015-06-01

    A series of plate impact experiments were conducted to investigate the shock response of a simulant for adobe, a traditional form of building material widely used around the world. Air dried bricks were sourced from the London brick company, dry machined and impacted at a range of velocities in a single stage gas gun. The shock Hugoniot was determined (Us = 2.26up + 0.33) as well as release information. The material was found to behave in a manner which was similar to that of loose sand and considerably less stiff than a weak porous sandstone. The effect of any cementing of the grains was examined by shocking powdered samples contained within a cell arrangement. The research was funded by DSTL through a WSTC contract.

  11. Speciation and bioaccessibility of mercury in adobe bricks and dirt floors in Huancavelica, Peru.

    PubMed

    Hagan, Nicole; Robins, Nicholas; Gonzales, Ruben Dario Espinoza; Hsu-Kim, Heileen

    2015-04-01

    Huancavelica, Peru, a historic cinnabar refining site, is one of the most mercury (Hg)-contaminated urban areas in the world. Exposure is amplified because residents build their adobe brick homes from contaminated soil. The objectives of this study were to compare two Hg-leaching procedures, and their application as risk-assessment screening tools in Hg-contaminated adobe brick homes in Huancavelica. The purpose was to evaluate potential health implications, particularly for children, after ingestion of Hg-contaminated particles. Hg was measured in adobe brick and dirt floor samples from 60 households by total Hg extraction, simulated gastric fluid (GF) extraction, and sequential selective extraction (SSE), which provides more detailed data but is resource-intensive. Most of the Hg present in samples was relatively insoluble, although in some households soluble Hg species were present at concentrations that may be of concern after ingestion. A strong correlation was identified between results from simulated GF extraction of adobe bricks and dirt floors and the more soluble fractions of Hg from SSE. Simulated GF extraction data were combined with ingestion and body mass characteristics for small children to compare potential risk of ingestion of Hg-contaminated soil with current health standards. Simulated GF extraction can be used as a risk assessment screening tool for effective allocation of time and resources to households that have measurable concentrations of bioaccessible Hg. Combining simulated GF extraction data with health standards enables intervention strategies targeted at households with the greatest potential health threat from ingestion of Hg-contaminated particles.

  12. ACHP | About the ACHP brochure

    Science.gov Websites

    business days for delivery. For more information, call or e-mail Denise Stanley (phone 202-517-0200 Adobe to download the free Acrobat Reader. For conversion of PDF to HTML, visit Access Adobe's free

  13. Digital version of "Open-File Report 92-179: Geologic map of the Cow Cove Quadrangle, San Bernardino County, California"

    USGS Publications Warehouse

    Wilshire, Howard G.; Bedford, David R.; Coleman, Teresa

    2002-01-01

    3. Plottable map representations of the database at 1:24,000 scale in PostScript and Adobe PDF formats. The plottable files consist of a color geologic map derived from the spatial database, composited with a topographic base map in the form of the USGS Digital Raster Graphic for the map area. Color symbology from each of these datasets is maintained, which can cause plot file sizes to be large.

  14. Cocaine

    MedlinePlus

    ... use among the nation’s youth. View Online Dirty Money and Cocaine Published: December 18, 2014 Dirty money: find out just how much of your cash ... June 27, 2018 NOTE: PDF documents require the free Adobe Reader . Flash content requires the free Adobe ...

  15. EBooks as PDF Files, in EPub Format or as Interactive IBooks? Digital Books in Physics Lessons of Secondary Education

    ERIC Educational Resources Information Center

    Lohr, Manfred

    2014-01-01

    This paper outlines the different capabilities of ebooks in the pdf, epub and ibook format in science teaching evaluated at the BG/BRG Schwechat. Over the recent years the school equipped with 100 personal computers and 28 iPads has become one of the leading e-learning schools in Austria. iPads show their advantages in the context of blended…

  16. Web-based X-ray quality control documentation.

    PubMed

    David, George; Burnett, Lou Ann; Schenkel, Robert

    2003-01-01

    The department of radiology at the Medical College of Georgia Hospital and Clinics has developed an equipment quality control web site. Our goal is to provide immediate access to virtually all medical physics survey data. The web site is designed to assist equipment engineers, department management and technologists. By improving communications and access to equipment documentation, we believe productivity is enhanced. The creation of the quality control web site was accomplished in three distinct steps. First, survey data had to be placed in a computer format. The second step was to convert these various computer files to a format supported by commercial web browsers. Third, a comprehensive home page had to be designed to provide convenient access to the multitude of surveys done in the various x-ray rooms. Because we had spent years previously fine-tuning the computerization of the medical physics quality control program, most survey documentation was already in spreadsheet or database format. A major technical decision was the method of conversion of survey spreadsheet and database files into documentation appropriate for the web. After an unsatisfactory experience with a HyperText Markup Language (HTML) converter (packaged with spreadsheet and database software), we tried creating Portable Document Format (PDF) files using Adobe Acrobat software. This process preserves the original formatting of the document and takes no longer than conventional printing; therefore, it has been very successful. Although the PDF file generated by Adobe Acrobat is a proprietary format, it can be displayed through a conventional web browser using the freely distributed Adobe Acrobat Reader program that is available for virtually all platforms. Once a user installs the software, it is automatically invoked by the web browser whenever the user follows a link to a file with a PDF extension. Although no confidential patient information is available on the web site, our legal

  17. Using Interactive 3D PDF for Exploring Complex Biomedical Data: Experiences and Solutions.

    PubMed

    Newe, Axel; Becker, Linda

    2016-01-01

    The Portable Document Format (PDF) is the most commonly used file format for the exchange of electronic documents. A lesser-known feature of PDF is the possibility to embed three-dimensional models and to display these models interactively with a qualified reader. This technology is well suited to present, to explore and to communicate complex biomedical data. This applies in particular for data which would suffer from a loss of information if it was reduced to a static two-dimensional projection. In this article, we present applications of 3D PDF for selected scholarly and clinical use cases in the biomedical domain. Furthermore, we present a sophisticated tool for the generation of respective PDF documents.

  18. Protocol for the E-Area Low Level Waste Facility Disposal Limits Database

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Swingle, R

    2006-01-31

    A database has been developed to contain the disposal limits for the E-Area Low Level Waste Facility (ELLWF). This database originates in the form of an EXCEL{copyright} workbook. The pertinent sheets are translated to PDF format using Adobe ACROBAT{copyright}. The PDF version of the database is accessible from the Solid Waste Division web page on SHRINE. In addition to containing the various disposal unit limits, the database also contains hyperlinks to the original references for all limits. It is anticipated that database will be revised each time there is an addition, deletion or revision of any of the ELLWF radionuclidemore » disposal limits.« less

  19. How to optimize radiological images captured from digital cameras, using the Adobe Photoshop 6.0 program.

    PubMed

    Chalazonitis, A N; Koumarianos, D; Tzovara, J; Chronopoulos, P

    2003-06-01

    Over the past decade, the technology that permits images to be digitized and the reduction in the cost of digital equipment allows quick digital transfer of any conventional radiological film. Images then can be transferred to a personal computer, and several software programs are available that can manipulate their digital appearance. In this article, the fundamentals of digital imaging are discussed, as well as the wide variety of optional adjustments that the Adobe Photoshop 6.0 (Adobe Systems, San Jose, CA) program can offer to present radiological images with satisfactory digital imaging quality.

  20. Enriching Learning for First Year Chemistry Students: Introduction of Adobe Connect

    ERIC Educational Resources Information Center

    Smith, Erica; Lye, Peter; Greatrex, Ben; Taylor, Michelle; Stupans, Ieva

    2013-01-01

    The study of chemistry is central within science and other associated degrees. At the University of New England in Armidale academics need to provide chemistry teaching in both a distance and the traditional on-campus mode within science and other degrees. This study explores the contribution that the adoption of Adobe Connect technology can make…

  1. The interactive presentation of 3D information obtained from reconstructed datasets and 3D placement of single histological sections with the 3D portable document format.

    PubMed

    de Boer, Bouke A; Soufan, Alexandre T; Hagoort, Jaco; Mohun, Timothy J; van den Hoff, Maurice J B; Hasman, Arie; Voorbraak, Frans P J M; Moorman, Antoon F M; Ruijter, Jan M

    2011-01-01

    Interpretation of the results of anatomical and embryological studies relies heavily on proper visualization of complex morphogenetic processes and patterns of gene expression in a three-dimensional (3D) context. However, reconstruction of complete 3D datasets is time consuming and often researchers study only a few sections. To help in understanding the resulting 2D data we developed a program (TRACTS) that places such arbitrary histological sections into a high-resolution 3D model of the developing heart. The program places sections correctly, robustly and as precisely as the best of the fits achieved by five morphology experts. Dissemination of 3D data is severely hampered by the 2D medium of print publication. Many insights gained from studying the 3D object are very hard to convey using 2D images and are consequently lost or cannot be verified independently. It is possible to embed 3D objects into a pdf document, which is a format widely used for the distribution of scientific papers. Using the freeware program Adobe Reader to interact with these 3D objects is reasonably straightforward; creating such objects is not. We have developed a protocol that describes, step by step, how 3D objects can be embedded into a pdf document. Both the use of TRACTS and the inclusion of 3D objects in pdf documents can help in the interpretation of 2D and 3D data, and will thus optimize communication on morphological issues in developmental biology.

  2. ACHP | Report to the President and Congress, 1998-1999

    Science.gov Websites

    five to seven business days for delivery. For more information, call or e-mail Denise Stanley (phone Reader. Please visit Adobe to download the free Acrobat Reader. For conversion of PDF to HTML, visit Access Adobe's free conversion service. Updated September 24, 2011 Return to Top

  3. Evaluation of chronic periapical lesions by digital subtraction radiography by using Adobe Photoshop CS: a technical report.

    PubMed

    Carvalho, Fabiola B; Gonçalves, Marcelo; Tanomaru-Filho, Mário

    2007-04-01

    The purpose of this study was to describe a new technique by using Adobe Photoshop CS (San Jose, CA) image-analysis software to evaluate the radiographic changes of chronic periapical lesions after root canal treatment by digital subtraction radiography. Thirteen upper anterior human teeth with pulp necrosis and radiographic image of chronic periapical lesion were endodontically treated and radiographed 0, 2, 4, and 6 months after root canal treatment by using a film holder. The radiographic films were automatically developed and digitized. The radiographic images taken 0, 2, 4, and 6 months after root canal therapy were submitted to digital subtraction in pairs (0 and 2 months, 2 and 4 months, and 4 and 6 months) choosing "image," "calculation," "subtract," and "new document" tools from Adobe Photoshop CS image-analysis software toolbar. The resulting images showed areas of periapical healing in all cases. According to this methodology, the healing or expansion of periapical lesions can be evaluated by means of digital subtraction radiography by using Adobe Photoshop CS software.

  4. PSTOOLS - FOUR PROGRAMS THAT INTERPRET/FORMAT POSTSCRIPT FILES

    NASA Technical Reports Server (NTRS)

    Choi, D.

    1994-01-01

    PSTOOLS is a package of four programs that operate on files written in the page description language, PostScript. The programs include a PostScript previewer for the IRIS workstation, a PostScript driver for the Matrix QCRZ film recorder, a PostScript driver for the Tektronix 4693D printer, and a PostScript code beautifier that formats PostScript files to be more legible. The three programs PSIRIS, PSMATRIX, and PSTEK are similar in that they all interpret the PostScript language and output the graphical results to a device, and they support color PostScript images. The common code which is shared by these three programs is included as a library of routines. PSPRETTY formats a PostScript file by appropriately indenting procedures and code delimited by "saves" and "restores." PSTOOLS does not use Adobe fonts. PSTOOLS is written in C-language for implementation on SGI IRIS 4D series workstations running IRIX 3.2 or later. A README file and UNIX man pages provide information regarding the installation and use of the PSTOOLS programs. A six-page manual which provides slightly more detailed information may be purchased separately. The standard distribution medium for this package is one .25 inch streaming magnetic tape cartridge in UNIX tar format. PSIRIS (the largest program) requires 1.2Mb of main memory. PSMATRIX requires the "gpib" board (IEEE 488) available from Silicon Graphics. Inc. The programs with graphical interfaces require that the IRIS have at least 24 bit planes. This package was developed in 1990 and updated in 1991. SGI, IRIS 4D, and IRIX are trademarks of Silicon Graphics, Inc. Matrix QCRZ is a registered trademark of the AGFA Group. Tektronix 4693D is a trademark of Tektronix, Inc. Adobe is a trademark of Adobe Systems Incorporated. PostScript is a registered trademark of Adobe Systems Incorporated. UNIX is a registered trademark of AT&T Bell Laboratories.

  5. New Tools to Convert PDF Math Contents into Accessible e-Books Efficiently.

    PubMed

    Suzuki, Masakazu; Terada, Yugo; Kanahori, Toshihiro; Yamaguchi, Katsuhito

    2015-01-01

    New features in our math-OCR software to convert PDF math contents into accessible e-books are shown. A method for recognizing PDF is thoroughly improved. In addition, contents in any selected area including math formulas in a PDF file can be cut and pasted into a document in various accessible formats, which is automatically recognized and converted into texts and accessible math formulas through this process. Combining it with our authoring tool for a technical document, one can easily produce accessible e-books in various formats such as DAISY, accessible EPUB3, DAISY-like HTML5, Microsoft Word with math objects and so on. Those contents are useful for various print-disabled students ranging from the blind to the dyslexic.

  6. Speciation and bioaccessibility of mercury in adobe bricks and dirt floors in Huancavelica, Peru

    EPA Science Inventory

    Background: Huancavelica, Peru, a historic cinnabar refining site, is one of the most mercury (Hg) contaminated urban areas in the world. Residents’ exposures are amplified because residents build their adobe brick homes from contaminated soil. Objectives: The objectives of th...

  7. Towards an easier creation of three-dimensional data for embedding into scholarly 3D PDF (Portable Document Format) files

    PubMed Central

    2015-01-01

    The Portable Document Format (PDF) allows for embedding three-dimensional (3D) models and is therefore particularly suitable to communicate respective data, especially as regards scholarly articles. The generation of the necessary model data, however, is still challenging, especially for inexperienced users. This prevents an unrestrained proliferation of 3D PDF usage in scholarly communication. This article introduces a new solution for the creation of three of types of 3D geometry (point clouds, polylines and triangle meshes), that is based on MeVisLab, a framework for biomedical image processing. This solution enables even novice users to generate the model data files without requiring programming skills and without the need for an intensive training by simply using it as a conversion tool. Advanced users can benefit from the full capability of MeVisLab to generate and export the model data as part of an overall processing chain. Although MeVisLab is primarily designed for handling biomedical image data, the new module is not restricted to this domain. It can be used for all scientific disciplines. PMID:25780759

  8. Towards an easier creation of three-dimensional data for embedding into scholarly 3D PDF (Portable Document Format) files.

    PubMed

    Newe, Axel

    2015-01-01

    The Portable Document Format (PDF) allows for embedding three-dimensional (3D) models and is therefore particularly suitable to communicate respective data, especially as regards scholarly articles. The generation of the necessary model data, however, is still challenging, especially for inexperienced users. This prevents an unrestrained proliferation of 3D PDF usage in scholarly communication. This article introduces a new solution for the creation of three of types of 3D geometry (point clouds, polylines and triangle meshes), that is based on MeVisLab, a framework for biomedical image processing. This solution enables even novice users to generate the model data files without requiring programming skills and without the need for an intensive training by simply using it as a conversion tool. Advanced users can benefit from the full capability of MeVisLab to generate and export the model data as part of an overall processing chain. Although MeVisLab is primarily designed for handling biomedical image data, the new module is not restricted to this domain. It can be used for all scientific disciplines.

  9. Layout-aware text extraction from full-text PDF of scientific articles.

    PubMed

    Ramakrishnan, Cartic; Patnia, Abhishek; Hovy, Eduard; Burns, Gully Apc

    2012-05-28

    The Portable Document Format (PDF) is the most commonly used file format for online scientific publications. The absence of effective means to extract text from these PDF files in a layout-aware manner presents a significant challenge for developers of biomedical text mining or biocuration informatics systems that use published literature as an information source. In this paper we introduce the 'Layout-Aware PDF Text Extraction' (LA-PDFText) system to facilitate accurate extraction of text from PDF files of research articles for use in text mining applications. Our paper describes the construction and performance of an open source system that extracts text blocks from PDF-formatted full-text research articles and classifies them into logical units based on rules that characterize specific sections. The LA-PDFText system focuses only on the textual content of the research articles and is meant as a baseline for further experiments into more advanced extraction methods that handle multi-modal content, such as images and graphs. The system works in a three-stage process: (1) Detecting contiguous text blocks using spatial layout processing to locate and identify blocks of contiguous text, (2) Classifying text blocks into rhetorical categories using a rule-based method and (3) Stitching classified text blocks together in the correct order resulting in the extraction of text from section-wise grouped blocks. We show that our system can identify text blocks and classify them into rhetorical categories with Precision1 = 0.96% Recall = 0.89% and F1 = 0.91%. We also present an evaluation of the accuracy of the block detection algorithm used in step 2. Additionally, we have compared the accuracy of the text extracted by LA-PDFText to the text from the Open Access subset of PubMed Central. We then compared this accuracy with that of the text extracted by the PDF2Text system, 2commonly used to extract text from PDF. Finally, we discuss preliminary error analysis for

  10. Layout-aware text extraction from full-text PDF of scientific articles

    PubMed Central

    2012-01-01

    Background The Portable Document Format (PDF) is the most commonly used file format for online scientific publications. The absence of effective means to extract text from these PDF files in a layout-aware manner presents a significant challenge for developers of biomedical text mining or biocuration informatics systems that use published literature as an information source. In this paper we introduce the ‘Layout-Aware PDF Text Extraction’ (LA-PDFText) system to facilitate accurate extraction of text from PDF files of research articles for use in text mining applications. Results Our paper describes the construction and performance of an open source system that extracts text blocks from PDF-formatted full-text research articles and classifies them into logical units based on rules that characterize specific sections. The LA-PDFText system focuses only on the textual content of the research articles and is meant as a baseline for further experiments into more advanced extraction methods that handle multi-modal content, such as images and graphs. The system works in a three-stage process: (1) Detecting contiguous text blocks using spatial layout processing to locate and identify blocks of contiguous text, (2) Classifying text blocks into rhetorical categories using a rule-based method and (3) Stitching classified text blocks together in the correct order resulting in the extraction of text from section-wise grouped blocks. We show that our system can identify text blocks and classify them into rhetorical categories with Precision1 = 0.96% Recall = 0.89% and F1 = 0.91%. We also present an evaluation of the accuracy of the block detection algorithm used in step 2. Additionally, we have compared the accuracy of the text extracted by LA-PDFText to the text from the Open Access subset of PubMed Central. We then compared this accuracy with that of the text extracted by the PDF2Text system, 2commonly used to extract text from PDF. Finally, we discuss

  11. Using Adobe Flash Animations of Electron Transport Chain to Teach and Learn Biochemistry

    ERIC Educational Resources Information Center

    Teplá, Milada; Klímová, Helena

    2015-01-01

    Teaching the subject of the electron transport chain is one of the most challenging aspects of the chemistry curriculum at the high school level. This article presents an educational program called "Electron Transport Chain" which consists of 14 visual animations including a biochemistry quiz. The program was created in the Adobe Flash…

  12. ChemEngine: harvesting 3D chemical structures of supplementary data from PDF files.

    PubMed

    Karthikeyan, Muthukumarasamy; Vyas, Renu

    2016-01-01

    Digital access to chemical journals resulted in a vast array of molecular information that is now available in the supplementary material files in PDF format. However, extracting this molecular information, generally from a PDF document format is a daunting task. Here we present an approach to harvest 3D molecular data from the supporting information of scientific research articles that are normally available from publisher's resources. In order to demonstrate the feasibility of extracting truly computable molecules from PDF file formats in a fast and efficient manner, we have developed a Java based application, namely ChemEngine. This program recognizes textual patterns from the supplementary data and generates standard molecular structure data (bond matrix, atomic coordinates) that can be subjected to a multitude of computational processes automatically. The methodology has been demonstrated via several case studies on different formats of coordinates data stored in supplementary information files, wherein ChemEngine selectively harvested the atomic coordinates and interpreted them as molecules with high accuracy. The reusability of extracted molecular coordinate data was demonstrated by computing Single Point Energies that were in close agreement with the original computed data provided with the articles. It is envisaged that the methodology will enable large scale conversion of molecular information from supplementary files available in the PDF format into a collection of ready- to- compute molecular data to create an automated workflow for advanced computational processes. Software along with source codes and instructions available at https://sourceforge.net/projects/chemengine/files/?source=navbar.Graphical abstract.

  13. Energy map of southwestern Wyoming - Energy data archived, organized, integrated, and accessible

    USGS Publications Warehouse

    Biewick, Laura; Jones, Nicholas R.; Wilson, Anna B.

    2013-01-01

    The Wyoming Landscape Conservation Initiative (WLCI) focuses on conserving world-class wildlife resources while facilitating responsible energy development in southwestern Wyoming. To further advance the objectives of the WLCI long-term, science-based effort, a comprehensive inventory of energy resource and production data is being published in two parts. Energy maps, data, documentation and spatial data processing capabilities are available in geodatabase, published map file (pmf), ArcMap document (mxd), Adobe Acrobat PDF map, and other digital formats that can be downloaded at the USGS website.

  14. Residential metal contamination and potential health risks of exposure in adobe brick houses in Potosí, Bolivia.

    PubMed

    McEwen, Abigail R; Hsu-Kim, Heileen; Robins, Nicholas A; Hagan, Nicole A; Halabi, Susan; Barras, Olivo; Richter, Daniel deB; Vandenberg, John J

    2016-08-15

    Potosí, Bolivia, is the site of centuries of historic and present-day mining of the Cerro Rico, a mountain known for its rich polymetallic deposits, and was the site of large-scale Colonial era silver refining operations. In this study, the concentrations of several metal and metalloid elements were quantified in adobe brick, dirt floor, and surface dust samples from 49 houses in Potosí. Median concentrations of total mercury (Hg), lead (Pb), and arsenic (As) were significantly greater than concentrations measured in Sucre, Bolivia, a non-mining town, and exceeded US-based soil screening levels. Adobe brick samples were further analyzed for bioaccessible concentrations of trace elements using a simulated gastric fluid (GF) extraction. Median GF extractable concentrations of Hg, As, and Pb were 0.085, 13.9, and 32.2% of the total element concentration, respectively. Total and GF extractable concentrations of Hg, As, and Pb were used to estimate exposure and potential health risks to children following incidental ingestion of adobe brick particles. Risks were assessed using a range of potential ingestion rates (50-1000mg/day). Overall, the results of the risk assessment show that the majority of households sampled contained concentrations of bioaccessible Pb and As, but not Hg, that represent a potential health risk. Even at the lowest ingestion rate considered, the majority of households exceeded the risk threshold for Pb, indicating that the concentrations of this metal are of particular concern. To our knowledge, this is the first study to quantify key trace elements in building materials in adobe brick houses and the results indicate that these houses are a potential source of exposure to metals and metalloids in South American mining communities. Additional studies are needed to fully characterize personal exposure and to understand potential adverse health outcomes within the community. Copyright © 2016 Elsevier B.V. All rights reserved.

  15. An easy and inexpensive method for quantitative analysis of endothelial damage by using vital dye staining and Adobe Photoshop software.

    PubMed

    Saad, Hisham A; Terry, Mark A; Shamie, Neda; Chen, Edwin S; Friend, Daniel F; Holiman, Jeffrey D; Stoeger, Christopher

    2008-08-01

    We developed a simple, practical, and inexpensive technique to analyze areas of endothelial cell loss and/or damage over the entire corneal area after vital dye staining by using a readily available, off-the-shelf, consumer software program, Adobe Photoshop. The purpose of this article is to convey a method of quantifying areas of cell loss and/or damage. Descemet-stripping automated endothelial keratoplasty corneal transplant surgery was performed by using 5 precut corneas on a human cadaver eye. Corneas were removed and stained with trypan blue and alizarin red S and subsequently photographed. Quantitative assessment of endothelial damage was performed by using Adobe Photoshop 7.0 software. The average difference for cell area damage for analyses performed by 1 observer twice was 1.41%. For analyses performed by 2 observers, the average difference was 1.71%. Three masked observers were 100% successful in matching the randomized stained corneas to their randomized processed Adobe images. Vital dye staining of corneal endothelial cells can be combined with Adobe Photoshop software to yield a quantitative assessment of areas of acute endothelial cell loss and/or damage. This described technique holds promise for a more consistent and accurate method to evaluate the surgical trauma to the endothelial cell layer in laboratory models. This method of quantitative analysis can probably be generalized to any area of research that involves areas that are differentiated by color or contrast.

  16. Influence of geological features (geochemistry and mineralogy) of soil wich constitutes adobes in their durability - Huambo, Angola.

    NASA Astrophysics Data System (ADS)

    Duarte, Isabel; Pedro, Elsa; Varum, Humberto; Mirão, José; Pinho, António

    2014-05-01

    After long years of war, great efforts have been made for the socio-economic development of Angola, mainly in the construction industry. Among the construction techniques, the Adobe is the most used in the province of Huambo, especially by low-income families, which constitute the majority. This technique was established as a historical heritage in the culture of that population. The Huambo province is located in the central region of Angola (Central Plateau) and is bounded on the northeast and east by the province of Bié, on the south and southern by province of Huila, and on the west by the province of Benguela and on the northwest by the province of Kwanza Sul. Has an area of 35,771 km2 and approximately 2,301,524 inhabitants, which corresponds to 58 inhabitants per km2 (Government of the Province of Huambo, 2006). The buildings in this province, particularly in rural areas, were deeply marked by war. Given the current scenario of development of the country and considering the possibility of integrate systems and traditional building materials, that respect the environment and fit harmoniously into its natural habitat, one of the alternative options in the actual construction, undergoes resume old solutions and traditional materials such as adobe construction.It is in this context that this project is part of a scientific research in order to permit the improvement and optimization of these traditional solutions, responding to current demands for social, economic and environmental sustainability. The adobe is a building element with potential degradation by water. Due to the climate, subtropical, hot and humid, and geomorphology of the province, about 1000 to 2000 meters of altitude and an extensive river system, these buildings can be vulnerable and present early degradation, exacerbated by lack of knowledge of the properties of geomaterials used and techniques that allow their stabilization and conservation. This paper aims to study the influence of

  17. Adobe InDesign vs. QuarkXPress and PageMaker: The Best of Both Worlds?

    ERIC Educational Resources Information Center

    Wilson, Bradley

    2000-01-01

    Evaluates the newly released Adobe InDesign software, finding that while it brings new life into desktop publishing, it is not yet a "must buy" for publications advisers. Compares specific features that are relevant for student publications, including: character, paragraph, drop caps, define styles, page setup, text wrap, defining and using…

  18. Staying on Top of Your Game and Scoring Big with Adobe Presenter Multimedia Tutorials

    ERIC Educational Resources Information Center

    Koury, Regina; Francis, Marcia J.; Gray, Catherine J.; Jardine, Spencer J.; Guo, Ruiling

    2010-01-01

    In order to reach distance students in times of financial uncertainty, librarians must be creative. While much has been written about Camtasia, Captivate and Jing tutorial software, Adobe Presenter, a Microsoft PowerPoint plug-in, has not been discussed. This article describes how our library team created multimedia tutorial projects at Idaho…

  19. Comments on the present state and future directions of PDF methods

    NASA Technical Reports Server (NTRS)

    Obrien, E. E.

    1992-01-01

    The one point probability density function (PDF) method is examined in light of its use in actual engineering problems. The PDF method, although relatively complicated, appears to be the only format available to handle the nonlinear stochastic difficulties caused by typical reaction kinetics. Turbulence modeling, if it is to play a central role in combustion modeling, has to be integrated with the chemistry in a way which produces accurate numerical solutions to combustion problems. It is questionable whether the development of turbulent models in isolation from the peculiar statistics of reactant concentrations is a fruitful line of development as far as propulsion is concerned. There are three issues for which additional viewgraphs are prepared: the one point pdf method; the amplitude mapping closure; and a hybrid strategy for replacing a full two point pdf treatment of reacting flows by a single point pdf and correlation functions. An appeal is made for the establishment of an adequate data base for compressible flow with reactions for Mach numbers of unity or higher.

  20. Geologic map of the San Bernardino North 7.5' quadrangle, San Bernardino County, California

    USGS Publications Warehouse

    Miller, F.K.; Matti, J.C.

    2001-01-01

    3. Portable Document Format (.pdf) files of: a. This Readme; includes an Appendix, containing data found in sbnorth_met.txt . b. The Description of Map Units identical to that found on the plot of the PostScript file. c. The same graphic as plotted in 2 above. (Test plots from this .pdf do not produce 1:24,000-scale maps. Use Adobe Acrobat pagesize setting to control map scale.) The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Miscellaneous Investigations Series (I-series) maps. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Even though this is an author-prepared report, every attempt has been made to closely adhere to the stratigraphic nomenclature of the U. S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above). If roads in some areas, especially forest roads that parallel topographic contours, do not show well on plots of the geologic map, we recommend use of the USGS San Bernardino North 7.5’ topographic quadrangle in conjunction with the geologic map.

  1. Ten Steps to Create Virtual Smile Design Templates With Adobe Photoshop® CS6.

    PubMed

    Sundar, Manoj Kumar; Chelliah, Venkataraman

    2018-03-01

    Computer design software has become a primary tool for communication among the dentist, patient, and ceramist. Virtual smile design can be carried out using various software programs, most of which use assorted forms of teeth templates that are made based on the concept of "golden proportion." Despite current advances in 3-dimensional imaging and smile designing, many clinicians still employ conventional design methods and analog (ie, man-made) mock-ups in assessing and establishing esthetic makeovers. To simplify virtual smile designing, the teeth templates should be readily available. No literature has provided details as to how to create these templates. This article explains a technique for creating different forms of teeth templates using Adobe Photoshop® CS6 that eventually can be used for smile design purposes, either in Photoshop or Microsoft Powerpoint. Clinically speaking, various smile design templates created using set proportions in Adobe Photoshop CS6 can be used in virtual smile designing, a valuable resource in diagnosis, treatment planning, and communicating with patients and ceramists, thus providing a platform for a successful esthetic rehabilitation.

  2. Asian Rhinoplasty: Preoperative Simulation and Planning Using Adobe Photoshop

    PubMed Central

    Kiranantawat, Kidakorn; Nguyen, Anh H.

    2015-01-01

    A rhinoplasty in Asians differs from a rhinoplasty performed in patients of other ethnicities. Surgeons should understand the concept of Asian beauty, the nasal anatomy of Asians, and common problems encountered while operating on the Asian nose. With this understanding, surgeons can set appropriate goals, choose proper operative procedures, and provide an outcome that satisfies patients. In this article the authors define the concept of an Asian rhinoplasty—a paradigm shift from the traditional on-top augmentation rhinoplasty to a structurally integrated augmentation rhinoplasty—and provide a step-by-step procedure for the use of Adobe Photoshop as a preoperative program to simulate the expected surgical outcome for patients and to develop a preoperative plan for surgeons. PMID:26648803

  3. Asian Rhinoplasty: Preoperative Simulation and Planning Using Adobe Photoshop.

    PubMed

    Kiranantawat, Kidakorn; Nguyen, Anh H

    2015-11-01

    A rhinoplasty in Asians differs from a rhinoplasty performed in patients of other ethnicities. Surgeons should understand the concept of Asian beauty, the nasal anatomy of Asians, and common problems encountered while operating on the Asian nose. With this understanding, surgeons can set appropriate goals, choose proper operative procedures, and provide an outcome that satisfies patients. In this article the authors define the concept of an Asian rhinoplasty-a paradigm shift from the traditional on-top augmentation rhinoplasty to a structurally integrated augmentation rhinoplasty-and provide a step-by-step procedure for the use of Adobe Photoshop as a preoperative program to simulate the expected surgical outcome for patients and to develop a preoperative plan for surgeons.

  4. Using Adobe Connect to Deliver Online Library Instruction to the RN to BSN Program

    ERIC Educational Resources Information Center

    Carlson, Kathleen

    2011-01-01

    This paper takes a look at how one academic health sciences librarian brought mediated literature searching to the distance RN to BSN nursing students. It takes a look at why Adobe Connect was the webinar software that was selected to deliver online instruction to the students. The article explains how students participated in a pre-class survey…

  5. SU-F-T-94: Plan2pdf - a Software Tool for Automatic Plan Report for Philips Pinnacle TPS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wu, C

    Purpose: To implement an automatic electronic PDF plan reporting tool for Philips Pinnacle treatment planning system (TPS) Methods: An electronic treatment plan reporting software is developed by us to enable fully automatic PDF report from Pinnacle TPS to external EMR programs such as MOSAIQ. The tool is named “plan2pdf”. plan2pdf is implemented using Pinnacle scripts, Java and UNIX shell scripts, without any external program needed. plan2pdf supports full auto-mode and manual mode reporting. In full auto-mode, with a single mouse click, plan2pdf will generate a detailed Pinnacle plan report in PDF format, which includes customizable cover page, Pinnacle plan summary,more » orthogonal views through each plan POI and maximum dose point, DRR for each beam, serial transverse views captured throughout the dose grid at a user specified interval, DVH and scorecard windows. The final PDF report is also automatically bookmarked for each section above for convenient plan review. The final PDF report can either be saved on a user specified folder on Pinnacle, or it can be automatically exported to an EMR import folder via a user configured FTP service. In manual capture mode, plan2pdf allows users to capture any Pinnacle plan by full screen, individual window or rectangular ROI drawn on screen. Furthermore, to avoid possible patients’ plan mix-up during auto-mode reporting, a user conflict check feature is included in plan2pdf: it prompts user to wait if another patient is being exported by plan2pdf by another user. Results: plan2pdf is tested extensively and successfully at our institution consists of 5 centers, 15 dosimetrists and 10 physicists, running Pinnacle version 9.10 on Enterprise servers. Conclusion: plan2pdf provides a highly efficient, user friendly and clinical proven platform for all Philips Pinnacle users, to generate a detailed plan report in PDF format for external EMR systems.« less

  6. 46 CFR 67.218 - Optional filing of instruments in portable document format as attachments to electronic mail.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... recording under § 67.200 may be submitted in portable document format (.pdf) as an attachment to electronic... submitted for filing in .pdf format pertains to a vessel that is not a currently documented vessel, a... with the National Vessel Documentation Center or must be submitted in .pdf format with the instrument...

  7. Mineral resources of the Adobe Town Wilderness Study Area, Sweetwater County, Wyoming

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Van Loenen, R.E.; Hill, R.H.; Bankey, V.

    1989-01-01

    The Adobe Town Wilderness Study Area is in Southwest Wyoming about 60 miles southeast of Rock Springs. This study area consists of flat-lying sedimentary rock of Eocene age located near the center of the Washakie Basin. There are no identified resources. This study area has a high resource potential for undiscovered oil and gas, in over pressured Cretaceous and Tertiary sandstone reservoirs. This study area has a low resource potential for undiscovered oil shale, zeolites, uranium, coal, and metallic minerals.

  8. Quantification of video-taped images in microcirculation research using inexpensive imaging software (Adobe Photoshop).

    PubMed

    Brunner, J; Krummenauer, F; Lehr, H A

    2000-04-01

    Study end-points in microcirculation research are usually video-taped images rather than numeric computer print-outs. Analysis of these video-taped images for the quantification of microcirculatory parameters usually requires computer-based image analysis systems. Most software programs for image analysis are custom-made, expensive, and limited in their applicability to selected parameters and study end-points. We demonstrate herein that an inexpensive, commercially available computer software (Adobe Photoshop), run on a Macintosh G3 computer with inbuilt graphic capture board provides versatile, easy to use tools for the quantification of digitized video images. Using images obtained by intravital fluorescence microscopy from the pre- and postischemic muscle microcirculation in the skinfold chamber model in hamsters, Photoshop allows simple and rapid quantification (i) of microvessel diameters, (ii) of the functional capillary density and (iii) of postischemic leakage of FITC-labeled high molecular weight dextran from postcapillary venules. We present evidence of the technical accuracy of the software tools and of a high degree of interobserver reliability. Inexpensive commercially available imaging programs (i.e., Adobe Photoshop) provide versatile tools for image analysis with a wide range of potential applications in microcirculation research.

  9. Extraction and labeling high-resolution images from PDF documents

    NASA Astrophysics Data System (ADS)

    Chachra, Suchet K.; Xue, Zhiyun; Antani, Sameer; Demner-Fushman, Dina; Thoma, George R.

    2013-12-01

    Accuracy of content-based image retrieval is affected by image resolution among other factors. Higher resolution images enable extraction of image features that more accurately represent the image content. In order to improve the relevance of search results for our biomedical image search engine, Open-I, we have developed techniques to extract and label high-resolution versions of figures from biomedical articles supplied in the PDF format. Open-I uses the open-access subset of biomedical articles from the PubMed Central repository hosted by the National Library of Medicine. Articles are available in XML and in publisher supplied PDF formats. As these PDF documents contain little or no meta-data to identify the embedded images, the task includes labeling images according to their figure number in the article after they have been successfully extracted. For this purpose we use the labeled small size images provided with the XML web version of the article. This paper describes the image extraction process and two alternative approaches to perform image labeling that measure the similarity between two images based upon the image intensity projection on the coordinate axes and similarity based upon the normalized cross-correlation between the intensities of two images. Using image identification based on image intensity projection, we were able to achieve a precision of 92.84% and a recall of 82.18% in labeling of the extracted images.

  10. Graph-based layout analysis for PDF documents

    NASA Astrophysics Data System (ADS)

    Xu, Canhui; Tang, Zhi; Tao, Xin; Li, Yun; Shi, Cao

    2013-03-01

    To increase the flexibility and enrich the reading experience of e-book on small portable screens, a graph based method is proposed to perform layout analysis on Portable Document Format (PDF) documents. Digital born document has its inherent advantages like representing texts and fractional images in explicit form, which can be straightforwardly exploited. To integrate traditional image-based document analysis and the inherent meta-data provided by PDF parser, the page primitives including text, image and path elements are processed to produce text and non text layer for respective analysis. Graph-based method is developed in superpixel representation level, and page text elements corresponding to vertices are used to construct an undirected graph. Euclidean distance between adjacent vertices is applied in a top-down manner to cut the graph tree formed by Kruskal's algorithm. And edge orientation is then used in a bottom-up manner to extract text lines from each sub tree. On the other hand, non-textual objects are segmented by connected component analysis. For each segmented text and non-text composite, a 13-dimensional feature vector is extracted for labelling purpose. The experimental results on selected pages from PDF books are presented.

  11. Computer Animation with Adobe Flash Professional Cs6 in Newton’s Law

    NASA Astrophysics Data System (ADS)

    Aji, S. D.; Hudha, M. N.; Huda, C.; Gufran, G.

    2018-01-01

    The purpose of this research is to develop computer-based physics learning media with Adobe Flash Professional CS6 on Newton’s Law of physics subject for senior high school (SMA / MA) class X. Type of research applied is Research and Development with ADDIE development model covering 5 stages: Analysis (Analysis), Design (Design), Development (Production), Implementation (Implementation) and Evaluation (Evaluation). The results of this study were tested toward media experts, media specialists, physics teachers, and students test results with media outcomes that are declared very feasible.

  12. Melvin Calvin and Carbon in Photosynthesis

    Science.gov Websites

    Report Download Adobe PDF Reader , April 1950 Top Melvin Calvin and photosynthesis apparatus Courtesy Lawrence Berkeley National Laboratory Calvin in the old Radiation Laboratory with the apparatus used in his

  13. The performance of adobe and other thermal mass materials in residential buildings

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Robertson, D.

    1986-01-01

    This paper reviews the history and current status of thermal mass research, and national, state, and local codes with respect to thermal mass; and offers specific recommendations on how best to use thermal mass for energy efficiency and comfort. Much of the material comes directly from the Southwest Thermal Mass Study (SWTMS), an experimental research study on the thermal performance of adobe conducted at Tesuque Pueblo, New Mexico, in the early 1980s. The focus is primarily on residential construction, although the theory and most of the recommendations apply to small commercial buildings as well.

  14. Photos of MRSA Infections

    MedlinePlus

    ... and Team Healthcare Providers Prevention Information and Advice Posters for the Athletic Community General MRSA Information and ... site? Adobe PDF file Microsoft PowerPoint file Microsoft Word file Microsoft Excel file Audio/Video file Apple ...

  15. Conservational PDF Equations of Turbulence

    NASA Technical Reports Server (NTRS)

    Shih, Tsan-Hsing; Liu, Nan-Suey

    2010-01-01

    Recently we have revisited the traditional probability density function (PDF) equations for the velocity and species in turbulent incompressible flows. They are all unclosed due to the appearance of various conditional means which are modeled empirically. However, we have observed that it is possible to establish a closed velocity PDF equation and a closed joint velocity and species PDF equation through conditions derived from the integral form of the Navier-Stokes equations. Although, in theory, the resulted PDF equations are neither general nor unique, they nevertheless lead to the exact transport equations for the first moment as well as all higher order moments. We refer these PDF equations as the conservational PDF equations. This observation is worth further exploration for its validity and CFD application

  16. A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior.

    PubMed

    Lear, Bridget C; Merrill, C Elaine; Lin, Jui-Ming; Schroeder, Analyne; Zhang, Luoying; Allada, Ravi

    2005-10-20

    The neuropeptide Pigment-Dispersing Factor (PDF) plays a critical role in mediating circadian control of behavior in Drosophila. Here we identify mutants (groom-of-PDF; gop) that display phase-advanced evening activity and poor free-running rhythmicity, phenocopying pdf mutants. In gop mutants, a spontaneous retrotransposon disrupts a coding exon of a G protein-coupled receptor, CG13758. Disruption of the receptor is accompanied by phase-advanced oscillations of the core clock protein PERIOD. Moreover, effects on circadian timing induced by perturbation of PDF neurons require gop. Yet PDF oscillations themselves remain robust in gop mutants, suggesting that GOP acts downstream of PDF. gop is expressed most strongly in the dorsal brain in regions that lie in proximity to PDF-containing nerve terminals. Taken together, these studies implicate GOP as a PDF receptor in Drosophila.

  17. Alexei Abrikosov and Superconductivity

    Science.gov Websites

    Superconducting Cuprates Based on Experimental Evidence, , DOE Technical Report Download Adobe PDF Reader Some links on this page may take you to non-federal websites. Their policies may differ from this site

  18. 76 FR 67129 - Notice of Request for Extension of a Currently Approved Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... attach a document that is a scanned Adobe PDF file, it must be scanned as text and not as an image, thus... in Washington, DC, on October 25, 2011. William J. Murphy, Manager, Federal Crop Insurance...

  19. Surficial geologic maps along the riparian zone of the Animas River and its headwater tributaries, Silverton to Durango, Colorado, with upper Animas River watershed gradient profiles

    USGS Publications Warehouse

    Blair, R.W.; Yager, D.B.; Church, S.E.

    2002-01-01

    This product consists of Adobe Acrobat .PDF format documents for 10 surficial geologic strip maps along the Animas River watershed from its major headwater tributaries, south to Durango, Colorado. The Animas River originates in the San Juan Mountains north of the historic mining town of Silverton, Colorado. The surficial geologic maps identify surficial deposits, such as flood-plain and terrace gravels, alluvial fans, glacial till, talus, colluvium, landslides, and bogs. Sixteen primary units were mapped that included human-related deposits and structures, eight alluvial, four colluvial, one glacial, travertine deposits, and undifferentiated bedrock. Each of the surficial geologic strip maps has .PDF links to surficial geology photographs, which enable the user to take a virtual tour of these deposits. Geochemical data collected from mapped surficial deposits that pre- and postdate mining activity have aided in determining the geochemical baseline in the watershed. Several photographs with their corresponding geochemical baseline profiles are accessible through .PDF links from several of the maps. A single coverage for all surficial deposits mapped is included as an ArcInfo shape file as an Arc Export format .e00 file. A gradient map for major headwater tributary streams to the Animas River is also included. The gradient map has stream segments that are color-coded based on relative variations in slope and .PDF format links to each stream gradient profile. Stream gradients were derived from U.S. Geological Survey 10-m digital elevation model data. This project was accomplished in support of the U.S. Geological Survey's Abandoned Mine Lands Initiative in the San Juan Mountains, Colorado.

  20. Application and evaluation of interactive 3D PDF for presenting and sharing planning results for liver surgery in clinical routine.

    PubMed

    Newe, Axel; Becker, Linda; Schenk, Andrea

    2014-01-01

    The Portable Document Format (PDF) is the de-facto standard for the exchange of electronic documents. It is platform-independent, suitable for the exchange of medical data, and allows for the embedding of three-dimensional (3D) surface mesh models. In this article, we present the first clinical routine application of interactive 3D surface mesh models which have been integrated into PDF files for the presentation and the exchange of Computer Assisted Surgery Planning (CASP) results in liver surgery. We aimed to prove the feasibility of applying 3D PDF in medical reporting and investigated the user experience with this new technology. We developed an interactive 3D PDF report document format and implemented a software tool to create these reports automatically. After more than 1000 liver CASP cases that have been reported in clinical routine using our 3D PDF report, an international user survey was carried out online to evaluate the user experience. Our solution enables the user to interactively explore the anatomical configuration and to have different analyses and various resection proposals displayed within a 3D PDF document covering only a single page that acts more like a software application than like a typical PDF file ("PDF App"). The new 3D PDF report offers many advantages over the previous solutions. According to the results of the online survey, the users have assessed the pragmatic quality (functionality, usability, perspicuity, efficiency) as well as the hedonic quality (attractiveness, novelty) very positively. The usage of 3D PDF for reporting and sharing CASP results is feasible and well accepted by the target audience. Using interactive PDF with embedded 3D models is an enabler for presenting and exchanging complex medical information in an easy and platform-independent way. Medical staff as well as patients can benefit from the possibilities provided by 3D PDF. Our results open the door for a wider use of this new technology, since the basic idea

  1. Leaving the structural ivory tower, assisted by interactive 3D PDF.

    PubMed

    Kumar, Pravin; Ziegler, Alexander; Grahn, Alexander; Hee, Chee Seng; Ziegler, Andreas

    2010-08-01

    The ability to embed interactive three-dimensional (3D) models into electronic publications in portable document format (PDF) greatly enhances the accessibility of molecular structures. Here, we report advances in this procedure and discuss what is needed to develop this format into a truly useful tool for the structural biology community as well as for readers who are less well trained in molecular visualization. Copyright 2010 Elsevier Ltd. All rights reserved.

  2. RTG-History, the Curiosity, Voyager, and New Horizons

    Science.gov Websites

    solar system for many years. Prior to New Horizons, the Apollo missions to the Moon, the Viking missions Report, January 11, 1991--April 30, 1998, DOE Technical Report Download Adobe PDF Reader , August 1998

  3. 77 FR 11483 - Request for Extension of a Currently Approved Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... that is a scanned Adobe PDF file, it must be scanned as text and not as an image, thus allowing FCIC to... February 17, 2012. William J. Murphy, Manager, Federal Crop Insurance Corporation. [FR Doc. 2012-4465 Filed...

  4. Improved biocompatibility of bicarbonate/lactate-buffered PDF is not related to pH.

    PubMed

    Zareie, Mohammad; Keuning, Eelco D; ter Wee, Piet M; Schalkwijk, Casper G; Beelen, Robert H J; van den Born, Jacob

    2006-01-01

    Chronic exposure to conventional peritoneal dialysis fluid (PDF) is associated with functional and structural alterations of the peritoneal membrane. The bioincompatibility of conventional PDF can be due to hypertonicity, high glucose concentration, lactate buffering system, presence of glucose degradation products (GDPs) and/or acidic pH. Although various investigators have studied the sole effects of hyperosmolarity, high glucose, GDPs and lactate buffer in experimental PD, less attention has been paid to the chronic impact of low pH in vivo. Rats received daily 10 ml of either conventional lactate-buffered PDF (pH 5.2; n=7), a standard bicarbonate/lactate-buffered PDF with physiological pH (n=8), bicarbonate/lactate-buffered PDF with acidic pH (adjusted to pH 5.2 with 1 N hydrochloride, n=5), or bicarbonate/lactate buffer, without glucose, pH 7.4 (n=7). Fluids were instilled via peritoneal catheters connected to implanted subcutaneous mini vascular access ports for 8 weeks. Control animals with or without peritoneal catheters served as control groups (n=8/group). Various functional (2 h PET) and morphological/cellular parameters were analyzed. Compared with control groups and the buffer group, conventional lactate-buffered PDF induced a number of morphological/cellular changes, including angiogenesis and fibrosis in various peritoneal tissues (all parameters P<0.05), accompanied by increased glucose absorption and reduced ultrafiltration capacity. Daily exposure to standard or acidified bicarbonate/lactate-buffered PDF improved the performance of the peritoneal membrane, evidenced by reduced new vessel formation in omentum (P<0.02) and parietal peritoneum (P<0.008), reduced fibrosis (P<0.02) and improved ultrafiltration capacity. No significant differences were found between standard and acidified bicarbonate/lactate-buffered PDF. During PET, acidic PDF was neutralized within 15 to 20 min. The bicarbonate/lactate-buffered PDF, acidity per se did not contribute

  5. PDF text classification to leverage information extraction from publication reports.

    PubMed

    Bui, Duy Duc An; Del Fiol, Guilherme; Jonnalagadda, Siddhartha

    2016-06-01

    Data extraction from original study reports is a time-consuming, error-prone process in systematic review development. Information extraction (IE) systems have the potential to assist humans in the extraction task, however majority of IE systems were not designed to work on Portable Document Format (PDF) document, an important and common extraction source for systematic review. In a PDF document, narrative content is often mixed with publication metadata or semi-structured text, which add challenges to the underlining natural language processing algorithm. Our goal is to categorize PDF texts for strategic use by IE systems. We used an open-source tool to extract raw texts from a PDF document and developed a text classification algorithm that follows a multi-pass sieve framework to automatically classify PDF text snippets (for brevity, texts) into TITLE, ABSTRACT, BODYTEXT, SEMISTRUCTURE, and METADATA categories. To validate the algorithm, we developed a gold standard of PDF reports that were included in the development of previous systematic reviews by the Cochrane Collaboration. In a two-step procedure, we evaluated (1) classification performance, and compared it with machine learning classifier, and (2) the effects of the algorithm on an IE system that extracts clinical outcome mentions. The multi-pass sieve algorithm achieved an accuracy of 92.6%, which was 9.7% (p<0.001) higher than the best performing machine learning classifier that used a logistic regression algorithm. F-measure improvements were observed in the classification of TITLE (+15.6%), ABSTRACT (+54.2%), BODYTEXT (+3.7%), SEMISTRUCTURE (+34%), and MEDADATA (+14.2%). In addition, use of the algorithm to filter semi-structured texts and publication metadata improved performance of the outcome extraction system (F-measure +4.1%, p=0.002). It also reduced of number of sentences to be processed by 44.9% (p<0.001), which corresponds to a processing time reduction of 50% (p=0.005). The rule-based multi

  6. United States Army Garrison - Miami (USAG-Miami)

    Science.gov Websites

    quality customer service. Let us know how to address your specific or community needs through ICE. Send this site use Adobe Acrobat Reader (PDF) This site is provided as a public service by United States

  7. Application and Evaluation of Interactive 3D PDF for Presenting and Sharing Planning Results for Liver Surgery in Clinical Routine

    PubMed Central

    Newe, Axel; Becker, Linda; Schenk, Andrea

    2014-01-01

    Background & Objectives The Portable Document Format (PDF) is the de-facto standard for the exchange of electronic documents. It is platform-independent, suitable for the exchange of medical data, and allows for the embedding of three-dimensional (3D) surface mesh models. In this article, we present the first clinical routine application of interactive 3D surface mesh models which have been integrated into PDF files for the presentation and the exchange of Computer Assisted Surgery Planning (CASP) results in liver surgery. We aimed to prove the feasibility of applying 3D PDF in medical reporting and investigated the user experience with this new technology. Methods We developed an interactive 3D PDF report document format and implemented a software tool to create these reports automatically. After more than 1000 liver CASP cases that have been reported in clinical routine using our 3D PDF report, an international user survey was carried out online to evaluate the user experience. Results Our solution enables the user to interactively explore the anatomical configuration and to have different analyses and various resection proposals displayed within a 3D PDF document covering only a single page that acts more like a software application than like a typical PDF file (“PDF App”). The new 3D PDF report offers many advantages over the previous solutions. According to the results of the online survey, the users have assessed the pragmatic quality (functionality, usability, perspicuity, efficiency) as well as the hedonic quality (attractiveness, novelty) very positively. Conclusion The usage of 3D PDF for reporting and sharing CASP results is feasible and well accepted by the target audience. Using interactive PDF with embedded 3D models is an enabler for presenting and exchanging complex medical information in an easy and platform-independent way. Medical staff as well as patients can benefit from the possibilities provided by 3D PDF. Our results open the door for a

  8. Sensitivity to Pigment-Dispersing Factor (PDF) Is Cell-Type Specific among PDF-Expressing Circadian Clock Neurons in the Madeira Cockroach.

    PubMed

    Gestrich, Julia; Giese, Maria; Shen, Wen; Zhang, Yi; Voss, Alexandra; Popov, Cyril; Stengl, Monika; Wei, HongYing

    2018-02-01

    Transplantation studies have pinpointed the circadian clock of the Madeira cockroach to the accessory medulla (AME) of the brain's optic lobes. The AME is innervated by approximately 240 adjacent neuropeptidergic neurons, including 12 pigment-dispersing factor (PDF)-expressing neurons anterior to the AME (aPDFMEs). Four of the aPDFMEs project contralaterally, controlling locomotor activity rhythms of the night-active cockroach. The present in vitro Ca 2+ imaging analysis focuses on contralaterally projecting AME neurons and their responses to PDF, GABA, and acetylcholine (ACh). First, rhodamine-dextran backfills from the contralateral optic stalk identified contralaterally projecting AME neurons, which were then dispersed in primary cell cultures. After characterization of PDF, GABA, and ACh responses, PDF immunocytochemistry identified ipsilaterally and contralaterally projecting PDFMEs. All PDF-sensitive clock neurons, PDF-immunoreactive clock neurons, and the majority of ipsilaterally and contralaterally projecting cells were excited by ACh. GABA inhibited all PDF-expressing clock neurons, and about half of other ipsilaterally projecting and most contralaterally projecting clock neurons. For the first time, we identified PDF autoreceptors in PDF-secreting cockroach circadian pacemakers. The medium-sized aPDFMEs and all other contralaterally projecting PDF-sensitive clock cells were inhibited by PDF. The ipsilaterally remaining small PDF-sensitive clock cells were activated by PDF. Only the largest aPDFME did not express PDF autoreceptors. We hypothesize that opposing PDF signaling generates 2 different ensembles of clock cells with antiphasic activity, regulating and maintaining a constant phase relationship between rest and activity cycles of the night-active cockroach.

  9. Mosaic of Digital Raster Soviet Topographic Maps of Afghanistan

    USGS Publications Warehouse

    Chirico, Peter G.; Warner, Michael B.

    2005-01-01

    EXPLANATION The data contained in this publication include scanned, geographically referenced digital raster graphics (DRGs) of Soviet 1:200,000 - scale topographic map quadrangles. The original Afghanistan topographic map series at 1:200,000 scale, for the entire country, was published by the Soviet military between 1985 and 1991(MTDGS, 85-91). Hard copies of these original paper maps were scanned using a large format scanner, reprojected into Geographic Coordinate System (GCS) coordinates, and then clipped to remove the map collars to create a seamless, topographic map base for the entire country. An index of all available topographic map sheets is displayed here: Index_Geo_DD.pdf. This publication also includes the originial topographic map quadrangles projected in Universal Transverse Mercator (UTM) projection. The country of Afghanistan spans three UTM Zones: Zone 41, Zone 42, and Zone 43. Maps are stored as GeoTIFFs in their respective UTM zone projection. Indexes of all available topographic map sheets in their respective UTM zone are displayed here: Index_UTM_Z41.pdf, Index_UTM_Z42.pdf, Index_UTM_Z43.pdf. An Adobe Acrobat PDF file of the U.S. Department of the Army's Technical Manual 30-548, is available (U.S. Army, 1958). This document has been translated into English for assistance in reading Soviet topographic map symbols.

  10. Possible costs associated with investigating and mitigating geologic hazards in rural areas of western San Mateo County, California with a section on using the USGS website to determine the cost of developing property for residences in rural parts of San Mateo County, California

    USGS Publications Warehouse

    Brabb, Earl E.; Roberts, Sebastian; Cotton, William R.; Kropp, Alan L.; Wright, Robert H.; Zinn, Erik N.; Digital database by Roberts, Sebastian; Mills, Suzanne K.; Barnes, Jason B.; Marsolek, Joanna E.

    2000-01-01

    This publication consists of a digital map database on a geohazards web site, http://kaibab.wr.usgs.gov/geohazweb/intro.htm, this text, and 43 digital map images available for downloading at this site. The report is stored as several digital files, in ARC export (uncompressed) format for the database, and Postscript and PDF formats for the map images. Several of the source data layers for the images have already been released in other publications by the USGS and are available for downloading on the Internet. These source layers are not included in this digital database, but rather a reference is given for the web site where the data can be found in digital format. The exported ARC coverages and grids lie in UTM zone 10 projection. The pamphlet, which only describes the content and character of the digital map database, is included as Postscript, PDF, and ASCII text files and is also available on paper as USGS Open-File Report 00-127. The full versatility of the spatial database is realized by importing the ARC export files into ARC/INFO or an equivalent GIS. Other GIS packages, including MapInfo and ARCVIEW, can also use the ARC export files. The Postscript map image can be used for viewing or plotting in computer systems with sufficient capacity, and the considerably smaller PDF image files can be viewed or plotted in full or in part from Adobe ACROBAT software running on Macintosh, PC, or UNIX platforms.

  11. PDF-ECG in clinical practice: A model for long-term preservation of digital 12-lead ECG data.

    PubMed

    Sassi, Roberto; Bond, Raymond R; Cairns, Andrew; Finlay, Dewar D; Guldenring, Daniel; Libretti, Guido; Isola, Lamberto; Vaglio, Martino; Poeta, Roberto; Campana, Marco; Cuccia, Claudio; Badilini, Fabio

    In clinical practice, data archiving of resting 12-lead electrocardiograms (ECGs) is mainly achieved by storing a PDF report in the hospital electronic health record (EHR). When available, digital ECG source data (raw samples) are only retained within the ECG management system. The widespread availability of the ECG source data would undoubtedly permit successive analysis and facilitate longitudinal studies, with both scientific and diagnostic benefits. PDF-ECG is a hybrid archival format which allows to store in the same file both the standard graphical report of an ECG together with its source ECG data (waveforms). Using PDF-ECG as a model to address the challenge of ECG data portability, long-term archiving and documentation, a real-world proof-of-concept test was conducted in a northern Italy hospital. A set of volunteers undertook a basic ECG using routine hospital equipment and the source data captured. Using dedicated web services, PDF-ECG documents were then generated and seamlessly uploaded in the hospital EHR, replacing the standard PDF reports automatically generated at the time of acquisition. Finally, the PDF-ECG files could be successfully retrieved and re-analyzed. Adding PDF-ECG to an existing EHR had a minimal impact on the hospital's workflow, while preserving the ECG digital data. Copyright © 2017 Elsevier Inc. All rights reserved.

  12. WPC North American Surface Analyses

    Science.gov Websites

    window and is a pdf file (requires Adobe Acrobat Reader to view). Create a Surface Analysis Loop North U.S. (South) Alaska Gulf of Alaska Color on White Black and White Display Loop Loop the sea-level

  13. Structures of E. coli peptide deformylase bound to formate: insight into the preference for Fe2+ over Zn2+ as the active site metal.

    PubMed

    Jain, Rinku; Hao, Bing; Liu, Ren-Peng; Chan, Michael K

    2005-04-06

    E. coli peptide deformylase (PDF) catalyzes the deformylation of nascent polypeptides generated during protein synthesis. While PDF was originally thought to be a zinc enzyme, subsequent studies revealed that the active site metal is iron. In an attempt to understand this unusual metal preference, high-resolution structures of Fe-, Co-, and Zn-PDF were determined in complex with its deformylation product, formate. In all three structures, the formate ion binds the metal and forms hydrogen-bonding interactions with the backbone nitrogen of Leu91, the amide side chain of Gln50, and the carboxylate side chain of Glu133. One key difference, however, is how the formate binds the metal. In Fe-PDF and Co-PDF, formate binds in a bidentate fashion, while in Zn-PDF, it binds in a monodentate fashion. Importantly, these structural results provide the first clues into the origins of PDF's metal-dependent activity differences. On the basis of these structures, we propose that the basis for the higher activity of Fe-PDF stems from the better ability of iron to bind and activate the tetrahedral transition state required for cleavage of the N-terminal formyl group.

  14. Electrical silencing of PDF neurons advances the phase of non-PDF clock neurons in Drosophila.

    PubMed

    Wu, Ying; Cao, Guan; Nitabach, Michael N

    2008-04-01

    Drosophila clock neurons exhibit self-sustaining cellular oscillations that rely in part on rhythmic transcriptional feedback loops. We have previously determined that electrical silencing of the pigment dispersing factor (PDF)-expressing lateral-ventral (LN(V)) pacemaker subset of fly clock neurons via expression of an inward-rectifier K(+) channel (Kir2.1) severely disrupts free-running rhythms of locomotor activity-most flies are arrhythmic and those that are not exhibit weak short-period rhythms-and abolishes LN(V) molecular oscillation in constant darkness. PDF is known to be an important LN(V) output signal. Here we examine the effects of electrical silencing of the LN(V) pacemakers on molecular rhythms in other, nonsilenced, subsets of clock neurons. In contrast to previously described cell-autonomous abolition of free-running molecular rhythms, we find that electrical silencing of the LN(V) pacemakers via Kir2.1 expression does not impair molecular rhythms in LN(D), DN1, and DN2 subsets of clock neurons. However, free-running molecular rhythms in these non-LN(V) clock neurons occur with advanced phase. Electrical silencing of LN(V)s phenocopies PDF null mutation (pdf (01) ) at both behavioral and molecular levels except for the complete abolition of free-running cellular oscillation in the LN(V)s themselves. LN(V) electrically silenced or pdf 01 flies exhibit weak free-running behavioral rhythms with short period, and the molecular oscillation in non-LN(V) neurons phase advances in constant darkness. That LN( V) electrical silencing leads to the same behavioral and non-LN( V) molecular phenotypes as pdf 01 suggests that persistence of LN(V) molecular oscillation in pdf 01 flies has no functional effect, either on behavioral rhythms or on non-LN(V) molecular rhythms. We thus conclude that functionally relevant signals from LN(V)s to non-LN(V) clock neurons and other downstream targets rely both on PDF signaling and LN(V) electrical activity, and that LN( V

  15. Economic assessment and pathogenic bacteria inhibition of bovine hide presoaking solutions formulated with enzymes that can remove adobe-type manure

    USDA-ARS?s Scientific Manuscript database

    The presoaking formulations that have recently been developed are effective in removing the damaging adobe type bovine manure and eco-friendly because the ingredients used are recycled and required only a quarter of the amount of biocide and surfactant that the industry is commonly using. The goal ...

  16. PDF approach for compressible turbulent reacting flows

    NASA Technical Reports Server (NTRS)

    Hsu, A. T.; Tsai, Y.-L. P.; Raju, M. S.

    1993-01-01

    The objective of the present work is to develop a probability density function (pdf) turbulence model for compressible reacting flows for use with a CFD flow solver. The probability density function of the species mass fraction and enthalpy are obtained by solving a pdf evolution equation using a Monte Carlo scheme. The pdf solution procedure is coupled with a compressible CFD flow solver which provides the velocity and pressure fields. A modeled pdf equation for compressible flows, capable of capturing shock waves and suitable to the present coupling scheme, is proposed and tested. Convergence of the combined finite-volume Monte Carlo solution procedure is discussed, and an averaging procedure is developed to provide smooth Monte-Carlo solutions to ensure convergence. Two supersonic diffusion flames are studied using the proposed pdf model and the results are compared with experimental data; marked improvements over CFD solutions without pdf are observed. Preliminary applications of pdf to 3D flows are also reported.

  17. 77 FR 42688 - Snapper-Grouper Fishery Off the Southern Atlantic States; Snapper-Grouper Management Measures

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... proposed rule to implement a regulatory amendment (Regulatory Amendment 12) to the Fishery Management Plan... can also attach additional files (up to 10MB) in Microsoft Word, Excel, WordPerfect, or Adobe PDF file... benefit to the nation, particularly with respect to providing food production and recreational...

  18. Effects of thickness, insulation, and surface color on the net heat loss through an adobe wall

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Herman, R.W.

    1980-01-01

    A finite difference computer program was written and run to study the net thermal losses through a large variety of adobe walls. Fifty-four different combinations of surface color, wall thickness, and insulation position and R value were modeled over a typical two week winter period for locations similar to Albuquerque, New Mexico. A transient analysis of the heat loss from the room to the interior wall surface was compared to both conventional U value and steady-state calculations.

  19. 76 FR 48202 - Trade Policy Staff Committee; Public Comments on the Caribbean Basin Economic Recovery Act and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-08

    ... Grenadines currently receive benefits only under CBERA. The Dominican Republic, El Salvador, Guatemala... country. The CAFTA-DR entered into force for El Salvador on March 1, 2006; for Honduras on April 1, 2006... & Upload File'' field. USTR prefers submissions in Microsoft Word (.doc) or Adobe Acrobat (.pdf). If the...

  20. 78 FR 35153 - Fisheries Off West Coast States; Modifications of the West Coast Commercial Salmon Fisheries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... seq. Dated: June 7, 2013. Kara Meckley, Acting Deputy Director, Office of Sustainable Fisheries... June 27, 2013. ADDRESSES: You may submit comments, identified by NOAA-NMFS-2012-0248, by any one of the... anonymous). Attachments to electronic comments will be accepted in Microsoft Word, Excel, or Adobe PDF file...

  1. 39 CFR 551.4 - Submission requirements and selection criteria.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    .... Interested persons submitting proposals are also encouraged to submit an Adobe Acrobat (.pdf) file saved on a... agencies and causes must satisfy the following requirements: (1) Interested persons must timely submit an original and 20 copies of the proposal. For purposes of this section, interested persons include, but are...

  2. 39 CFR 551.4 - Submission requirements and selection criteria.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    .... Interested persons submitting proposals are also encouraged to submit an Adobe Acrobat (.pdf) file saved on a... agencies and causes must satisfy the following requirements: (1) Interested persons must timely submit an original and 20 copies of the proposal. For purposes of this section, interested persons include, but are...

  3. 39 CFR 551.4 - Submission requirements and selection criteria.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Interested persons submitting proposals are also encouraged to submit an Adobe Acrobat (.pdf) file saved on a... agencies and causes must satisfy the following requirements: (1) Interested persons must timely submit an original and 20 copies of the proposal. For purposes of this section, interested persons include, but are...

  4. 39 CFR 551.4 - Submission requirements and selection criteria.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    .... Interested persons submitting proposals are also encouraged to submit an Adobe Acrobat (.pdf) file saved on a... agencies and causes must satisfy the following requirements: (1) Interested persons must timely submit an original and 20 copies of the proposal. For purposes of this section, interested persons include, but are...

  5. Pdf - Transport equations for chemically reacting flows

    NASA Technical Reports Server (NTRS)

    Kollmann, W.

    1989-01-01

    The closure problem for the transport equations for pdf and the characteristic functions of turbulent, chemically reacting flows is addressed. The properties of the linear and closed equations for the characteristic functional for Eulerian and Lagrangian variables are established, and the closure problem for the finite-dimensional case is discussed for pdf and characteristic functions. It is shown that the closure for the scalar dissipation term in the pdf equation developed by Dopazo (1979) and Kollmann et al. (1982) results in a single integral, in contrast to the pdf, where double integration is required. Some recent results using pdf methods obtained for turbulent flows with combustion, including effects of chemical nonequilibrium, are discussed.

  6. Edwin M. McMillan, Neptunium, Phase Stability, and the Synchrotron

    Science.gov Websites

    Elements) * McMillan in LBNL History Edwin M. McMillan Courtesy of Lawrence Berkeley National Laboratory Elements: Early History (Nobel Lecture), DOE Technical Report Download Adobe PDF Reader , December 1951 1907 - 1991, National Academy of Sciences Oral History Transcript -- Dr. Edwin McMillan, American

  7. Luis Alvarez, the Hydrogen Bubble Chamber, Tritium, and Dinosaurs

    Science.gov Websites

    linear accelerator, patented three types of radar still used today, designed an instrument that for 15 is available in documents and on the Web. Documents: Berkeley Proton Linear Accelerator, DOE Technical Report Download Adobe PDF Reader , June 1985 History of Proton Linear Accelerators, DOE Technical

  8. Recent progress in the joint velocity-scalar PDF method

    NASA Technical Reports Server (NTRS)

    Anand, M. S.

    1995-01-01

    This viewgraph presentation discusses joint velocity-scalar PDF method; turbulent combustion modeling issues for gas turbine combustors; PDF calculations for a recirculating flow; stochastic dissipation model; joint PDF calculations for swirling flows; spray calculations; reduced kinetics/manifold methods; parallel processing; and joint PDF focus areas.

  9. A computer simulated phantom study of tomotherapy dose optimization based on probability density functions (PDF) and potential errors caused by low reproducibility of PDF.

    PubMed

    Sheng, Ke; Cai, Jing; Brookeman, James; Molloy, Janelle; Christopher, John; Read, Paul

    2006-09-01

    Lung tumor motion trajectories measured by four-dimensional CT or dynamic MRI can be converted to a probability density function (PDF), which describes the probability of the tumor at a certain position, for PDF based treatment planning. Using this method in simulated sequential tomotherapy, we study the dose reduction of normal tissues and more important, the effect of PDF reproducibility on the accuracy of dosimetry. For these purposes, realistic PDFs were obtained from two dynamic MRI scans of a healthy volunteer within a 2 week interval. The first PDF was accumulated from a 300 s scan and the second PDF was calculated from variable scan times from 5 s (one breathing cycle) to 300 s. Optimized beam fluences based on the second PDF were delivered to the hypothetical gross target volume (GTV) of a lung phantom that moved following the first PDF The reproducibility between two PDFs varied from low (78%) to high (94.8%) when the second scan time increased from 5 s to 300 s. When a highly reproducible PDF was used in optimization, the dose coverage of GTV was maintained; phantom lung receiving 10%-20% prescription dose was reduced by 40%-50% and the mean phantom lung dose was reduced by 9.6%. However, optimization based on PDF with low reproducibility resulted in a 50% underdosed GTV. The dosimetric error increased nearly exponentially as the PDF error increased. Therefore, although the dose of the tumor surrounding tissue can be theoretically reduced by PDF based treatment planning, the reliability and applicability of this method highly depend on if a reproducible PDF exists and is measurable. By correlating the dosimetric error and PDF error together, a useful guideline for PDF data acquisition and patient qualification for PDF based planning can be derived.

  10. A computer simulated phantom study of tomotherapy dose optimization based on probability density functions (PDF) and potential errors caused by low reproducibility of PDF

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sheng, Ke; Cai Jing; Brookeman, James

    2006-09-15

    Lung tumor motion trajectories measured by four-dimensional CT or dynamic MRI can be converted to a probability density function (PDF), which describes the probability of the tumor at a certain position, for PDF based treatment planning. Using this method in simulated sequential tomotherapy, we study the dose reduction of normal tissues and more important, the effect of PDF reproducibility on the accuracy of dosimetry. For these purposes, realistic PDFs were obtained from two dynamic MRI scans of a healthy volunteer within a 2 week interval. The first PDF was accumulated from a 300 s scan and the second PDF wasmore » calculated from variable scan times from 5 s (one breathing cycle) to 300 s. Optimized beam fluences based on the second PDF were delivered to the hypothetical gross target volume (GTV) of a lung phantom that moved following the first PDF. The reproducibility between two PDFs varied from low (78%) to high (94.8%) when the second scan time increased from 5 s to 300 s. When a highly reproducible PDF was used in optimization, the dose coverage of GTV was maintained; phantom lung receiving 10%-20% prescription dose was reduced by 40%-50% and the mean phantom lung dose was reduced by 9.6%. However, optimization based on PDF with low reproducibility resulted in a 50% underdosed GTV. The dosimetric error increased nearly exponentially as the PDF error increased. Therefore, although the dose of the tumor surrounding tissue can be theoretically reduced by PDF based treatment planning, the reliability and applicability of this method highly depend on if a reproducible PDF exists and is measurable. By correlating the dosimetric error and PDF error together, a useful guideline for PDF data acquisition and patient qualification for PDF based planning can be derived.« less

  11. Daily rhythms in locomotor circuits in Drosophila involve PDF

    PubMed Central

    Pírez, Nicolás; Christmann, Bethany L.

    2013-01-01

    The neuropeptide pigment-dispersing factor (PDF) has been studied extensively in Drosophila, and its role in circadian time-keeping has been firmly established. The role of PDF outside of the clock circuit, however, is poorly understood. A recent study suggested that PDF may act on the ellipsoid body (EB) to link the clock and sleep/activity circuits. We performed whole brain optical imaging with the fluorescence resonance energy transfer (FRET)-based cAMP sensor Epac1-camps expressed under control of the pdfR promoter to address how the clock and sleep deprivation affect the physiology of these cells. Basal cAMP levels in EB were regulated both by PDF and synaptic inputs that are controlled by the circadian clock. Acute application of PDF to the brain caused a significant, and PDF-receptor-dependent, increase in cAMP in EB cells. Application of TTX to block circuit-mediated effects of PDF increased the morning response but not the response at night, implying the existence of a temporally regulated, PDF-stimulated input that blocks cAMP generation. ACh produced both direct (TTX-insensitive) and indirect (TTX-sensitive) increases in cAMP during the day but was totally TTX-insensitive at night, indicating that ACh-stimulated inputs to the EB are suppressed at night. Sleep deprivation did not affect the cAMP responses of these cells to either PDF or ACh. These results suggest a novel role for PDF as a modulator of activity outside of the clock circuit. By elucidating the mechanisms by which the neuropeptide PDF act on its target cells, our work contributes to our understating of how the central clock coordinates activity and sleep. PMID:23678016

  12. Daily rhythms in locomotor circuits in Drosophila involve PDF.

    PubMed

    Pírez, Nicolás; Christmann, Bethany L; Griffith, Leslie C

    2013-08-01

    The neuropeptide pigment-dispersing factor (PDF) has been studied extensively in Drosophila, and its role in circadian time-keeping has been firmly established. The role of PDF outside of the clock circuit, however, is poorly understood. A recent study suggested that PDF may act on the ellipsoid body (EB) to link the clock and sleep/activity circuits. We performed whole brain optical imaging with the fluorescence resonance energy transfer (FRET)-based cAMP sensor Epac1-camps expressed under control of the pdfR promoter to address how the clock and sleep deprivation affect the physiology of these cells. Basal cAMP levels in EB were regulated both by PDF and synaptic inputs that are controlled by the circadian clock. Acute application of PDF to the brain caused a significant, and PDF-receptor-dependent, increase in cAMP in EB cells. Application of TTX to block circuit-mediated effects of PDF increased the morning response but not the response at night, implying the existence of a temporally regulated, PDF-stimulated input that blocks cAMP generation. ACh produced both direct (TTX-insensitive) and indirect (TTX-sensitive) increases in cAMP during the day but was totally TTX-insensitive at night, indicating that ACh-stimulated inputs to the EB are suppressed at night. Sleep deprivation did not affect the cAMP responses of these cells to either PDF or ACh. These results suggest a novel role for PDF as a modulator of activity outside of the clock circuit. By elucidating the mechanisms by which the neuropeptide PDF act on its target cells, our work contributes to our understating of how the central clock coordinates activity and sleep.

  13. 77 FR 34943 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... document is the document published in the Federal Register. Free Internet access to the official edition of... text telephone (TTY), call the Federal Relay Service (FRS), toll free, at 1- 800-877-8339. Individuals... use PDF you must have Adobe Acrobat Reader, which is available free at the site. You may also access...

  14. 77 FR 27756 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-11

    ... document is the document published in the Federal Register. Free Internet access to the official edition of... free, at 1- 800-877-8339. Individuals with disabilities may obtain this document in an accessible... use PDF you must have Adobe Acrobat Reader, which is available free at the site. You may also access...

  15. 75 FR 26703 - Atlantic Coastal Fisheries Cooperative Management Act Provisions; Weakfish Fishery

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... any one of the following methods: Electronic Submissions: Submit all electronic public comments via... submit attachments to electronic comments in Microsoft Word, Excel, WordPerfect, or Adobe PDF file... the tip of the lower jaw with the mouth closed to the end of the lower tip of the tail) in or from the...

  16. 75 FR 61138 - Committee on Measures of Student Success

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... Education Statistics, Institute of Education Sciences, Department of Education. ACTION: Notice of an open... following site: http://www.ed.gov/news/fed-register/index.html . To use PDF you must have Adobe Acrobat..., Institute of Education Sciences. [FR Doc. 2010-24782 Filed 10-1-10; 8:45 am] BILLING CODE 4000-01-P ...

  17. 76 FR 2674 - Committee on Measures of Student Success

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... Education Statistics, Institute of Education Sciences, Department of Education. ACTION: Notice of an open... following site: http://www.ed.gov/news/fed-register/index.html . To use PDF you must have Adobe Acrobat..., Institute of Education Sciences. [FR Doc. 2011-800 Filed 1-13-11; 8:45 am] BILLING CODE 4000-01-P ...

  18. 78 FR 52032 - Atlantic Highly Migratory Species; 2006 Consolidated Atlantic Highly Migratory Species Fishery...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... may submit attachments to electronic comments in Microsoft Word or Excel, WordPerfect, or Adobe PDF... categories per the percentages outlined in the 2006 Consolidated HMS FMP. In other words, the combined effect... other words, if a vessel is not allowed access to the Cape Hatteras Gear Restricted Area due to the...

  19. Theoretical Synthesis of Mixed Materials for CO2 Capture Applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Duan, Yuhua

    These pages provide an example of the layout and style required for the preparation of four-page papers for the TechConnect World 2015 technical proceedings.Documents must be submitted in electronic (Adobe PDFfile) format. Please study the enclosed materials beforebeginning the final preparation of your paper. Proofread your paper carefully before submitting (it will appear in the published volume in exactly the same form). Your PDF manuscript must be uploaded online by April 11th, 2015.You will receive no proofs. Begin your paper with an abstract of no more than 18 lines. Thoroughly summarize your article in this section since this text willmore » be used for on-line listing and classification of the publication.« less

  20. Suggested Format for Acute Toxicity Studies

    EPA Pesticide Factsheets

    This document suggests the format for final reports on pesticide studies (right column of the tables in the document) and provides instructions for the creation of PDF Version 1.3 electronic submission documents (left column of the tables).

  1. PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.

    PubMed

    Meelkop, Ellen; Temmerman, Liesbet; Janssen, Tom; Suetens, Nick; Beets, Isabel; Van Rompay, Liesbeth; Shanmugam, Nilesh; Husson, Steven J; Schoofs, Liliane

    2012-09-25

    In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-coupled receptors are activated by three neuropeptides, pigment dispersing factors 1a, 1b and 2, which are encoded by pdf-1 and pdf-2. We isolated a PDF receptor loss-of-function allele (lst34) by means of a mutagenesis screen and show that the PDF signaling system is involved in locomotion and egg-laying. We demonstrate that the pdfr-1 mutant phenocopies the defective locomotor behavior of the pdf-1 mutant and that pdf-1 and pdf-2 behave antagonistically. All three PDF receptor splice variants are involved in the regulation of locomotor behavior. Cell specific rescue experiments show that this pdf mediated behavior is regulated by neurons rather than body wall muscles. We also show that egg-laying patterns of pdf-1 and pdf-2 mutants are affected, but not those of pdfr-1 mutants, pointing to a novel role for the PDF-system in the regulation of egg-laying. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  2. A compression algorithm for the combination of PDF sets.

    PubMed

    Carrazza, Stefano; Latorre, José I; Rojo, Juan; Watt, Graeme

    The current PDF4LHC recommendation to estimate uncertainties due to parton distribution functions (PDFs) in theoretical predictions for LHC processes involves the combination of separate predictions computed using PDF sets from different groups, each of which comprises a relatively large number of either Hessian eigenvectors or Monte Carlo (MC) replicas. While many fixed-order and parton shower programs allow the evaluation of PDF uncertainties for a single PDF set at no additional CPU cost, this feature is not universal, and, moreover, the a posteriori combination of the predictions using at least three different PDF sets is still required. In this work, we present a strategy for the statistical combination of individual PDF sets, based on the MC representation of Hessian sets, followed by a compression algorithm for the reduction of the number of MC replicas. We illustrate our strategy with the combination and compression of the recent NNPDF3.0, CT14 and MMHT14 NNLO PDF sets. The resulting compressed Monte Carlo PDF sets are validated at the level of parton luminosities and LHC inclusive cross sections and differential distributions. We determine that around 100 replicas provide an adequate representation of the probability distribution for the original combined PDF set, suitable for general applications to LHC phenomenology.

  3. The pdf approach to turbulent flow

    NASA Technical Reports Server (NTRS)

    Kollmann, W.

    1990-01-01

    This paper provides a detailed discussion of the theory and application of probability density function (pdf) methods, which provide a complete statistical description of turbulent flow fields at a single point or a finite number of points. The basic laws governing the flow of Newtonian fluids are set up in the Eulerian and the Lagrangian frame, and the exact and linear equations for the characteristic functionals in those frames are discussed. Pdf equations in both frames are derived as Fourier transforms of the equations of the characteristic functions. Possible formulations for the nonclosed terms in the pdf equation are discussed, their properties are assessed, and closure modes for the molecular-transport and the fluctuating pressure-gradient terms are reviewed. The application of pdf methods to turbulent combustion flows, supersonic flows, and the interaction of turbulence with shock waves is discussed.

  4. Comments on PDF methods

    NASA Technical Reports Server (NTRS)

    Chen, J.-Y.

    1992-01-01

    Viewgraphs are presented on the following topics: the grand challenge of combustion engineering; research of probability density function (PDF) methods at Sandia; experiments of turbulent jet flames (Masri and Dibble, 1988); departures from chemical equilibrium; modeling turbulent reacting flows; superequilibrium OH radical; pdf modeling of turbulent jet flames; scatter plot for CH4 (methane) and O2 (oxygen); methanol turbulent jet flames; comparisons between predictions and experimental data; and turbulent C2H4 jet flames.

  5. 77 FR 67624 - Fisheries of the Northeastern United States; Atlantic Herring Fishery; Adjustment to 2013 Annual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ...). Attachments to electronic comments will be accepted in Microsoft Word or Excel, WordPerfect, or Adobe PDF... accuracy against the scanned image of the paper VTRs submitted by the owner/ operator of the vessel. VTR... combination of recent fishing activity and a review of the scanned images of the original VTR were used to...

  6. Ernest O. Lawrence and the Cyclotron

    Science.gov Websites

    Speed Protons Without the Use of High Voltages; Physical Review, Vol. 38, [Issue 4: 834, August 15, 1931 Report Download Adobe PDF Reader , August 27, 1952 Top Lawrence Honored: 1957 Enrico Fermi Award Science World to Think Big," Newsline, August 3, 2001. E. O. Lawrence Remembered, LBNL Conversation

  7. 77 FR 16542 - President's Advisory Commission on Educational Excellence for Hispanics

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ...: Tuesday, April 3, 2012. Time: 9 a.m.-5 p.m. Pacific Daylight Time. ADDRESSES: Loker Student Union Ballroom, California State University, Dominguez Hills, 1000 E. Victoria St., Carson, CA 90747, Tel: 310-243- 3303. FOR... use PDF, you must have Adobe Acrobat Reader, which is available free at this site. For questions about...

  8. 75 FR 13735 - Fund for the Improvement of Postsecondary Education (FIPSE)-Special Focus Competition: Program...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... published in the Federal Register. Free Internet access to the official edition of the Federal Register and.... Electronic Access to This Document: You can view this document, as well as all other documents of this... Internet at the following site: http://www.ed.gov/news/fedregister . To use PDF you must have Adobe Acrobat...

  9. Analysis and Comparison of Various Requirements Management Tools for Use in the Shipbuilding Industry

    DTIC Science & Technology

    2006-09-01

    such products as MS Word, MS Excel, MS PowerPoint, Adobe Acrobat, Adobe FrameMaker , Claris FileMaker, Adobe PhotoShop and Adobe Illustrator, it is easy...Adobe FrameMaker , etc. Information can be exported out in the same formats as above plus HTML, MS PowerPoint, and MS Outlook. DOORS is very user...including Postscript, RTF (for PowerPoint), HTML, Interleaf, SVG, FrameMaker , HP LaserJet, HPGL, and EPS. Examples of such charts produced by DOORS

  10. Geologic map of the Devore 7.5' quadrangle, San Bernardino County, California

    USGS Publications Warehouse

    Morton, Douglas M.; Matti, Jonathan C.

    2001-01-01

    This Open-File Report contains a digital geologic map database of the Devore 7.5' quadrangle, San Bernardino County, California, that includes: 1. ARC/INFO (Environmental Systems Research Institute) version 7.2.1 coverages of the various components of the geologic map 2. A PostScript (.ps) file to plot the geologic map on a topographic base, containing a Correlation of Map Units diagram, a Description of Map Units, an index map, and a regional structure map 3. Portable Document Format (.pdf) files of: a. This Readme; includes an Appendix, containing metadata details found in devre_met.txt b. The same graphic as plotted in 2 above. (Test plots from this .pdf do not produce 1:24,000-scale maps. Adobe Acrobat page-size settings control map scale.) The Correlation of Map Units and Description of Map Units are in the editorial format of USGS Miscellaneous Investigations Series maps (I-maps) but have not been edited to comply with I-map standards. Within the geologic-map data package, map units are identified by such standard geologic-map criteria as formation name, age, and lithology. Even though this is an author-prepared report, every attempt has been made to closely adhere to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above). If roads in some areas, especially forest roads that parallel topographic contours, do not show well on plots of the geologic map, we recommend use of the USGS Devore 7.5’ topographic quadrangle in conjunction with the geologic map.

  11. GrinLine identification using digital imaging and Adobe Photoshop.

    PubMed

    Bollinger, Susan A; Brumit, Paula C; Schrader, Bruce A; Senn, David R

    2009-03-01

    The purpose of this study was to outline a method by which an antemortem photograph of a victim can be critically compared with a postmortem photograph in an effort to facilitate the identification process. Ten subjects, between 27 and 55 years old provided historical pictures of themselves exhibiting a broad smile showing anterior teeth to some extent (a grin). These photos were termed "antemortem" for the purpose of the study. A digital camera was used to take a current photo of each subject's grin. These photos represented the "postmortem" images. A single subject's "postmortem" photo set was randomly selected to be the "unknown victim." These combined data of the unknown and the 10 antemortem subjects were digitally stored and, using Adobe Photoshop software, the images were sized and oriented for comparative analysis. The goal was to devise a technique that could facilitate the accurate determination of which "antemortem" subject was the "unknown." The generation of antemortem digital overlays of the teeth visible in a grin and the comparison of those overlays to the images of the postmortem dentition is the foundation of the technique. The comparisons made using the GrinLine Identification Technique may assist medical examiners and coroners in making identifications or exclusions.

  12. PDF4LHC recommendations for LHC Run II

    DOE PAGES

    Butterworth, Jon; Carrazza, Stefano; Cooper-Sarkar, Amanda; ...

    2016-01-06

    We provide an updated recommendation for the usage of sets of parton distribution functions (PDFs) and the assessment of PDF and PDF+αs uncertainties suitable for applications at the LHC Run II. We review developments since the previous PDF4LHC recommendation, and discuss and compare the new generation of PDFs, which include substantial information from experimental data from the Run I of the LHC. We then propose a new prescription for the combination of a suitable subset of the available PDF sets, which is presented in terms of a single combined PDF set. Lastly, we finally discuss tools which allow for themore » delivery of this combined set in terms of optimized sets of Hessian eigenvectors or Monte Carlo replicas, and their usage, and provide some examples of their application to LHC phenomenology.« less

  13. Recent advances in PDF modeling of turbulent reacting flows

    NASA Technical Reports Server (NTRS)

    Leonard, Andrew D.; Dai, F.

    1995-01-01

    This viewgraph presentation concludes that a Monte Carlo probability density function (PDF) solution successfully couples with an existing finite volume code; PDF solution method applied to turbulent reacting flows shows good agreement with data; and PDF methods must be run on parallel machines for practical use.

  14. Transcriptional regulation of the human mitochondrial peptide deformylase (PDF).

    PubMed

    Pereira-Castro, Isabel; Costa, Luís Teixeira da; Amorim, António; Azevedo, Luisa

    2012-05-18

    The last years of research have been particularly dynamic in establishing the importance of peptide deformylase (PDF), a protein of the N-terminal methionine excision (NME) pathway that removes formyl-methionine from mitochondrial-encoded proteins. The genomic sequence of the human PDF gene is shared with the COG8 gene, which encodes a component of the oligomeric golgi complex, a very unusual case in Eukaryotic genomes. Since PDF is crucial in maintaining mitochondrial function and given the atypical short distance between the end of COG8 coding sequence and the PDF initiation codon, we investigated whether the regulation of the human PDF is affected by the COG8 overlapping partner. Our data reveals that PDF has several transcription start sites, the most important of which only 18 bp from the initiation codon. Furthermore, luciferase-activation assays using differently-sized fragments defined a 97 bp minimal promoter region for human PDF, which is capable of very strong transcriptional activity. This fragment contains a potential Sp1 binding site highly conserved in mammalian species. We show that this binding site, whose mutation significantly reduces transcription activation, is a target for the Sp1 transcription factor, and possibly of other members of the Sp family. Importantly, the entire minimal promoter region is located after the end of COG8's coding region, strongly suggesting that the human PDF preserves an independent regulation from its overlapping partner. Copyright © 2012 Elsevier Inc. All rights reserved.

  15. Determination of early diastolic LV vortex formation time (T*) via the PDF formalism: a kinematic model of filling.

    PubMed

    Ghosh, Erina; Shmuylovich, Leonid; Kovacs, Sandor J

    2009-01-01

    The filling (diastolic) function of the human left ventricle is most commonly assessed by echocardiography, a non-invasive imaging modality. To quantify diastolic function (DF) empiric indices are obtained from the features (height, duration, area) of transmitral flow velocity contour, obtained by echocardiography. The parameterized diastolic filling (PDF) formalism is a kinematic model developed by Kovács et. al. which incorporates the suction pump attribute of the left ventricle and facilitates DF quantitation by analysis of echocardiographic transmitral flow velocity contours in terms of stiffness (k), relaxation (c) and load (x(0)). A complementary approach developed by Gharib et. al., uses fluid mechanics and characterizes DF in terms of vortex formation time (T*) derived from streamline features formed by the jet of blood aspirated into the ventricle. Both of these methods characterize DF using a causality-based approach. In this paper, we derive T*'s kinematic analogue T*(kinematic) in terms of k, c and x(0). A comparison between T*(kinematic) and T*(fluid) (mechanic) obtained from averaged transmitral velocity and mitral annulus diameter, is presented. We found that T* calculated by the two methods were comparable and T*(kinematic) correlated with the peak LV recoil driving force kx(0).

  16. Signaling of pigment-dispersing factor (PDF) in the Madeira cockroach Rhyparobia maderae.

    PubMed

    Wei, Hongying; Yasar, Hanzey; Funk, Nico W; Giese, Maria; Baz, El-Sayed; Stengl, Monika

    2014-01-01

    The insect neuropeptide pigment-dispersing factor (PDF) is a functional ortholog of vasoactive intestinal polypeptide, the coupling factor of the mammalian circadian pacemaker. Despite of PDF's importance for synchronized circadian locomotor activity rhythms its signaling is not well understood. We studied PDF signaling in primary cell cultures of the accessory medulla, the circadian pacemaker of the Madeira cockroach. In Ca²⁺ imaging studies four types of PDF-responses were distinguished. In regularly bursting type 1 pacemakers PDF application resulted in dose-dependent long-lasting increases in Ca²⁺ baseline concentration and frequency of oscillating Ca²⁺ transients. Adenylyl cyclase antagonists prevented PDF-responses in type 1 cells, indicating that PDF signaled via elevation of intracellular cAMP levels. In contrast, in type 2 pacemakers PDF transiently raised intracellular Ca²⁺ levels even after blocking adenylyl cyclase activity. In patch clamp experiments the previously characterized types 1-4 could not be identified. Instead, PDF-responses were categorized according to ion channels affected. Application of PDF inhibited outward potassium or inward sodium currents, sometimes in the same neuron. In a comparison of Ca²⁺ imaging and patch clamp experiments we hypothesized that in type 1 cells PDF-dependent rises in cAMP concentrations block primarily outward K⁺ currents. Possibly, this PDF-dependent depolarization underlies PDF-dependent phase advances of pacemakers. Finally, we propose that PDF-dependent concomitant modulation of K⁺ and Na⁺ channels in coupled pacemakers causes ultradian membrane potential oscillations as prerequisite to efficient synchronization via resonance.

  17. Signaling of Pigment-Dispersing Factor (PDF) in the Madeira Cockroach Rhyparobia maderae

    PubMed Central

    Funk, Nico W.; Giese, Maria; Baz, El-Sayed; Stengl, Monika

    2014-01-01

    The insect neuropeptide pigment-dispersing factor (PDF) is a functional ortholog of vasoactive intestinal polypeptide, the coupling factor of the mammalian circadian pacemaker. Despite of PDF's importance for synchronized circadian locomotor activity rhythms its signaling is not well understood. We studied PDF signaling in primary cell cultures of the accessory medulla, the circadian pacemaker of the Madeira cockroach. In Ca2+ imaging studies four types of PDF-responses were distinguished. In regularly bursting type 1 pacemakers PDF application resulted in dose-dependent long-lasting increases in Ca2+ baseline concentration and frequency of oscillating Ca2+ transients. Adenylyl cyclase antagonists prevented PDF-responses in type 1 cells, indicating that PDF signaled via elevation of intracellular cAMP levels. In contrast, in type 2 pacemakers PDF transiently raised intracellular Ca2+ levels even after blocking adenylyl cyclase activity. In patch clamp experiments the previously characterized types 1–4 could not be identified. Instead, PDF-responses were categorized according to ion channels affected. Application of PDF inhibited outward potassium or inward sodium currents, sometimes in the same neuron. In a comparison of Ca2+ imaging and patch clamp experiments we hypothesized that in type 1 cells PDF-dependent rises in cAMP concentrations block primarily outward K+ currents. Possibly, this PDF-dependent depolarization underlies PDF-dependent phase advances of pacemakers. Finally, we propose that PDF-dependent concomitant modulation of K+ and Na+ channels in coupled pacemakers causes ultradian membrane potential oscillations as prerequisite to efficient synchronization via resonance. PMID:25269074

  18. PDF modeling of near-wall turbulent flows

    NASA Astrophysics Data System (ADS)

    Dreeben, Thomas David

    1997-06-01

    Pdf methods are extended to include modeling of wall- bounded turbulent flows. For flows in which resolution of the viscous sublayer is desired, a Pdf near-wall model is developed in which the Generalized Langevin model is combined with an exact model for viscous transport. Durbin's method of elliptic relaxation is used to incorporate the wall effects into the governing equations without the use of wall functions or damping functions. Close to the wall, the Generalized Langevin model provides an analogy to the effect of the fluctuating continuity equation. This enables accurate modeling of the near-wall turbulent statistics. Demonstrated accuracy for fully-developed channel flow is achieved with a Pdf/Monte Carlo simulation, and with its related Reynolds-stress closure. For flows in which the details of the viscous sublayer are not important, a Pdf wall- function method is developed with the Simplified Langevin model.

  19. PDF and cAMP enhance PER stability in Drosophila clock neurons

    PubMed Central

    Li, Yue; Guo, Fang; Shen, James; Rosbash, Michael

    2014-01-01

    The neuropeptide PDF is important for Drosophila circadian rhythms: pdf01 (pdf-null) animals are mostly arrhythmic or short period in constant darkness and have an advanced activity peak in light–dark conditions. PDF contributes to the amplitude, synchrony, as well as the pace of circadian rhythms within clock neurons. PDF is known to increase cAMP levels in PDR receptor (PDFR)-containing neurons. However, there is no known connection of PDF or of cAMP with the Drosophila molecular clockworks. We discovered that the mutant period gene perS ameliorates the phenotypes of pdf-null flies. The period protein (PER) is a well-studied repressor of clock gene transcription, and the perS protein (PERS) has a markedly short half-life. The result therefore suggests that the PDF-mediated increase in cAMP might lengthen circadian period by directly enhancing PER stability. Indeed, increasing cAMP levels and cAMP-mediated protein kinase A (PKA) activity stabilizes PER, in S2 tissue culture cells and in fly circadian neurons. Adding PDF to fly brains in vitro has a similar effect. Consistent with these relationships, a light pulse causes more prominent PER degradation in pdf01 circadian neurons than in wild-type neurons. The results indicate that PDF contributes to clock neuron synchrony by increasing cAMP and PKA, which enhance PER stability and decrease clock speed in intrinsically fast-paced PDFR-containing clock neurons. We further suggest that the more rapid degradation of PERS bypasses PKA regulation and makes the pace of clock neurons more uniform, allowing them to avoid much of the asynchrony caused by the absence of PDF. PMID:24707054

  20. PDF and cAMP enhance PER stability in Drosophila clock neurons.

    PubMed

    Li, Yue; Guo, Fang; Shen, James; Rosbash, Michael

    2014-04-01

    The neuropeptide PDF is important for Drosophila circadian rhythms: pdf(01) (pdf-null) animals are mostly arrhythmic or short period in constant darkness and have an advanced activity peak in light-dark conditions. PDF contributes to the amplitude, synchrony, as well as the pace of circadian rhythms within clock neurons. PDF is known to increase cAMP levels in PDR receptor (PDFR)-containing neurons. However, there is no known connection of PDF or of cAMP with the Drosophila molecular clockworks. We discovered that the mutant period gene per(S) ameliorates the phenotypes of pdf-null flies. The period protein (PER) is a well-studied repressor of clock gene transcription, and the per(S) protein (PERS) has a markedly short half-life. The result therefore suggests that the PDF-mediated increase in cAMP might lengthen circadian period by directly enhancing PER stability. Indeed, increasing cAMP levels and cAMP-mediated protein kinase A (PKA) activity stabilizes PER, in S2 tissue culture cells and in fly circadian neurons. Adding PDF to fly brains in vitro has a similar effect. Consistent with these relationships, a light pulse causes more prominent PER degradation in pdf(01) circadian neurons than in wild-type neurons. The results indicate that PDF contributes to clock neuron synchrony by increasing cAMP and PKA, which enhance PER stability and decrease clock speed in intrinsically fast-paced PDFR-containing clock neurons. We further suggest that the more rapid degradation of PERS bypasses PKA regulation and makes the pace of clock neurons more uniform, allowing them to avoid much of the asynchrony caused by the absence of PDF.

  1. Publications - PDF 96-18 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 96-18 Publication Details Title: Major and trace element analyses of Cretaceous plutonic Bibliographic Reference Newberry, R.J., 1996, Major and trace element analyses of Cretaceous plutonic rocks in pdf1996_018.pdf (571.0 K) Keywords Geochemistry; Geology; Igneous Rocks; Major Oxides; Plutonic Rocks

  2. Conditional probability distribution function of "energy transfer rate" (PDF(ɛ|PVI)) as compared with its counterpart of temperature (PDF(T|PVI)) at the same condition of fluctuation

    NASA Astrophysics Data System (ADS)

    He, Jiansen; Wang, Yin; Pei, Zhongtian; Zhang, Lei; Tu, Chuanyi

    2017-04-01

    Energy transfer rate of turbulence is not uniform everywhere but suggested to follow a certain distribution, e.g., lognormal distribution (Kolmogorov 1962). The inhomogeneous transfer rate leads to emergence of intermittency, which may be identified with some parameter, e.g., normalized partial variance increments (PVI) (Greco et al., 2009). Large PVI of magnetic field fluctuations are found to have a temperature distribution with the median and mean values higher than that for small PVI level (Osman et al., 2012). However, there is a large proportion of overlap between temperature distributions associated with the smaller and larger PVIs. So it is recognized that only PVI cannot fully determine the temperature, since the one-to-one mapping relationship does not exist. One may be curious about the reason responsible for the considerable overlap of conditional temperature distribution for different levels of PVI. Usually the hotter plasma with higher temperature is speculated to be heated more with more dissipation of turbulence energy corresponding to more energy cascading rate, if the temperature fluctuation of the eigen wave mode is not taken into account. To explore the statistical relationship between turbulence cascading and plasma thermal state, we aim to study and reveal, for the first time, the conditional probability function of "energy transfer rate" under different levels of PVI condition (PDF(ɛ|PVI)), and compare it with the conditional probability function of temperature. The conditional probability distribution function, PDF(ɛ|PVI), is derived from PDF(PVI|ɛ)·PDF(ɛ)/PDF(PVI) according to the Bayesian theorem. PDF(PVI) can be obtained directly from the data. PDF(ɛ) is derived from the conjugate-gradient inversion of PDF(PVI) by assuming reasonably that PDF(δB|σ) is a Gaussian distribution, where PVI=|δB|/ σ and σ ( ɛι)1/3. PDF(ɛ) can also be acquired from fitting PDF(δB) with an integral function ∫PDF(δB|σ)PDF(σ)d σ. As a result

  3. Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons.

    PubMed

    Tomchik, Seth M; Davis, Ronald L

    2008-04-24

    In Drosophila, the neuropeptide PDF is required for circadian rhythmicity, but it is unclear where PDF acts. In this issue of Neuron, Shafer et al. use a novel bioimaging methodology to demonstrate that PDF elevates cAMP in nearly all clock neurons. Thus, PDF apparently exerts more widespread effects on the circadian clock network than suggested by previous studies of PDF receptor expression.

  4. An Overview of the NCC Spray/Monte-Carlo-PDF Computations

    NASA Technical Reports Server (NTRS)

    Raju, M. S.; Liu, Nan-Suey (Technical Monitor)

    2000-01-01

    This paper advances the state-of-the-art in spray computations with some of our recent contributions involving scalar Monte Carlo PDF (Probability Density Function), unstructured grids and parallel computing. It provides a complete overview of the scalar Monte Carlo PDF and Lagrangian spray computer codes developed for application with unstructured grids and parallel computing. Detailed comparisons for the case of a reacting non-swirling spray clearly highlight the important role that chemistry/turbulence interactions play in the modeling of reacting sprays. The results from the PDF and non-PDF methods were found to be markedly different and the PDF solution is closer to the reported experimental data. The PDF computations predict that some of the combustion occurs in a predominantly premixed-flame environment and the rest in a predominantly diffusion-flame environment. However, the non-PDF solution predicts wrongly for the combustion to occur in a vaporization-controlled regime. Near the premixed flame, the Monte Carlo particle temperature distribution shows two distinct peaks: one centered around the flame temperature and the other around the surrounding-gas temperature. Near the diffusion flame, the Monte Carlo particle temperature distribution shows a single peak. In both cases, the computed PDF's shape and strength are found to vary substantially depending upon the proximity to the flame surface. The results bring to the fore some of the deficiencies associated with the use of assumed-shape PDF methods in spray computations. Finally, we end the paper by demonstrating the computational viability of the present solution procedure for its use in 3D combustor calculations by summarizing the results of a 3D test case with periodic boundary conditions. For the 3D case, the parallel performance of all the three solvers (CFD, PDF, and spray) has been found to be good when the computations were performed on a 24-processor SGI Origin work-station.

  5. The present state and future directions of PDF methods

    NASA Technical Reports Server (NTRS)

    Pope, S. B.

    1992-01-01

    The objectives of the workshop are presented in viewgraph format, as is this entire article. The objectives are to discuss the present status and the future direction of various levels of engineering turbulence modeling related to Computational Fluid Dynamics (CFD) computations for propulsion; to assure that combustion is an essential part of propulsion; and to discuss Probability Density Function (PDF) methods for turbulent combustion. Essential to the integration of turbulent combustion models is the development of turbulent model, chemical kinetics, and numerical method. Some turbulent combustion models typically used in industry are the k-epsilon turbulent model, the equilibrium/mixing limited combustion, and the finite volume codes.

  6. Adobe connect as a viable tool for educating Russian students by American professors

    NASA Astrophysics Data System (ADS)

    Tulinov, B. M.; Myakinina, N. P.; Tworek, A. R.; Mazetov, O. Y.

    2017-01-01

    This article explores the possibility of using videoconferencing via Adobe Connect software as a new form of distance learning and contains a case study of inviting leading professors from top universities of the United States of America to participate in the educational process of the students of the Institute of International Relations, NRNU MEPhI. The article describes the general course structure and the technical means used for setting up the course, discloses the technique used to ensure active student participation and outlines the key competencies that students are expected to gain after completing the course. The conclusions drawn from this case study can be of interest when solving the issues of modern techniques used for online distance education. The authors hope that these forms of education will also indirectly contribute to the stabilization of relations between the Russian Federation and the United States of America on a non-governmental level in the field of international scientific and technological cooperation.

  7. A PDF closure model for compressible turbulent chemically reacting flows

    NASA Technical Reports Server (NTRS)

    Kollmann, W.

    1992-01-01

    The objective of the proposed research project was the analysis of single point closures based on probability density function (pdf) and characteristic functions and the development of a prediction method for the joint velocity-scalar pdf in turbulent reacting flows. Turbulent flows of boundary layer type and stagnation point flows with and without chemical reactions were be calculated as principal applications. Pdf methods for compressible reacting flows were developed and tested in comparison with available experimental data. The research work carried in this project was concentrated on the closure of pdf equations for incompressible and compressible turbulent flows with and without chemical reactions.

  8. Design and application of PDF model for extracting

    NASA Astrophysics Data System (ADS)

    Xiong, Lei

    2013-07-01

    In order to change the steps of contributions in editorial department system from two steps to one, this paper advocates that the technology of extracting the information of PDF files should be transplanted from PDF reader into IEEE Xplore contribution system and that it should be combined with uploading in batch skillfully to enable editors to upload PDF files about 1GB in batch for once. Computers will extract the information of the title, author, address, mailbox, abstract and key words of thesis voluntarily for later retrieval so as to save plenty of labor, material and finance for editorial department.

  9. Improvements and new features in the PDF module

    NASA Technical Reports Server (NTRS)

    Norris, Andrew T.

    1995-01-01

    This viewgraph presentation discusses what models are used in this package and what their advantages and disadvantages are, how the probability density function (PDF) model is implemented and the features of the program, and what can be expected in the future from the NASA Lewis PDF code.

  10. Persistent Deterioration of Functioning (PDF) and change in well-being in older persons.

    PubMed

    Jonker, Angèle A; Comijs, Hannie C; Knipscheer, Kees C; Deeg, Dorly J

    2008-10-01

    It is often assumed that aging is accompanied by diverse and constant functional and cognitive decline, and it is therefore surprising that the well-being of older persons does not appear to decline in the same way. This study investigates longitudinally whether well-being in older persons changes due to Persistent Deterioration of Functioning (PDF). Data were collected in the context of the Longitudinal Aging Study Amsterdam (LASA). Conditions of PDF are persistent decline in cognitive functioning, physical functioning and increase in chronic diseases. Measurements of well-being included life satisfaction, positive affect, and valuation of life. T-tests were used to analyse mean difference scores for well-being, and univariate and multivariate regression analyses were performed to examine changes in three well-being outcomes in relation to PDF. Cross-sectional analyses showed significant differences and associations between the two PDF subgroups and non- PDF for well-being at T3. In longitudinal analyses, we found significant decreases in and associations with wellbeing over time in respondents fulfilling one PDF condition (mild PDF). For respondents fulfilling two or more PDF conditions (severe PDF), longitudinally no significant associations were found. Cognitive aspects of well-being (life satisfaction and valuation of life) and the affective element (positive affect) of well-being appear to be influenced negatively by mild PDF, whereas well-being does not seem to be diminished in persons with more severe PDF. This may be due to the ability to accept finally the inevitable situation of severe PDF.

  11. Alaska Elections

    Science.gov Websites

    Adobe Acrobat Reader: Get Adobe Acrobat Reader . STATEWIDE SUMMARY - OFFICIAL This report is the statewide summary of all races appearing on the ballot. To view this report, select one of the formats

  12. Application of PDF methods to compressible turbulent flows

    NASA Astrophysics Data System (ADS)

    Delarue, B. J.; Pope, S. B.

    1997-09-01

    A particle method applying the probability density function (PDF) approach to turbulent compressible flows is presented. The method is applied to several turbulent flows, including the compressible mixing layer, and good agreement is obtained with experimental data. The PDF equation is solved using a Lagrangian/Monte Carlo method. To accurately account for the effects of compressibility on the flow, the velocity PDF formulation is extended to include thermodynamic variables such as the pressure and the internal energy. The mean pressure, the determination of which has been the object of active research over the last few years, is obtained directly from the particle properties. It is therefore not necessary to link the PDF solver with a finite-volume type solver. The stochastic differential equations (SDE) which model the evolution of particle properties are based on existing second-order closures for compressible turbulence, limited in application to low turbulent Mach number flows. Tests are conducted in decaying isotropic turbulence to compare the performances of the PDF method with the Reynolds-stress closures from which it is derived, and in homogeneous shear flows, at which stage comparison with direct numerical simulation (DNS) data is conducted. The model is then applied to the plane compressible mixing layer, reproducing the well-known decrease in the spreading rate with increasing compressibility. It must be emphasized that the goal of this paper is not as much to assess the performance of models of compressibility effects, as it is to present an innovative and consistent PDF formulation designed for turbulent inhomogeneous compressible flows, with the aim of extending it further to deal with supersonic reacting flows.

  13. Comparative analysis of Pdf-mediated circadian behaviors between Drosophila melanogaster and D. virilis.

    PubMed

    Bahn, Jae Hoon; Lee, Gyunghee; Park, Jae H

    2009-03-01

    A group of small ventrolateral neurons (s-LN(v)'s) are the principal pacemaker for circadian locomotor rhythmicity of Drosophila melanogaster, and the pigment-dispersing factor (Pdf) neuropeptide plays an essential role as a clock messenger within these neurons. In our comparative studies on Pdf-associated circadian rhythms, we found that daily locomotor activity patterns of D. virilis were significantly different from those of D. melanogaster. Activities of D. virilis adults were mainly restricted to the photophase under light:dark cycles and subsequently became arrhythmic or weakly rhythmic in constant conditions. Such activity patterns resemble those of Pdf(01) mutant of D. melanogaster. Intriguingly, endogenous D. virilis Pdf (DvPdf) expression was not detected in the s-LN(v)-like neurons in the adult brains, implying that the Pdf(01)-like behavioral phenotypes of D. virilis are attributed in part to the lack of DvPdf in the s-LN(v)-like neurons. Heterologous transgenic analysis showed that cis-regulatory elements of the DvPdf transgene are capable of directing their expression in all endogenous Pdf neurons including s-LN(v)'s, as well as in non-Pdf clock neurons (LN(d)'s and fifth s-LN(v)) in a D. melanogaster host. Together these findings suggest a significant difference in the regulatory mechanisms of Pdf transcription between the two species and such a difference is causally associated with species-specific establishment of daily locomotor activity patterns.

  14. Problems with Interagency Integration in Contemporary Operations

    DTIC Science & Technology

    2014-12-04

    IBM Center for the Business of Government, 2013. Adobe PDF eBook . Journals Armstrong, Nicholas J., and Corri Zoli. "Post 9/11 Stability... issues are due to poor use of existing doctrine to facilitate integrated planning. Past and current doctrine offers guidelines and principles to direct...sharing, and undefined roles created conflict in civil- military relationships. These issues are due to poor use of existing doctrine to facilitate

  15. Auditory presentation and synchronization in Adobe Flash and HTML5/JavaScript Web experiments.

    PubMed

    Reimers, Stian; Stewart, Neil

    2016-09-01

    Substantial recent research has examined the accuracy of presentation durations and response time measurements for visually presented stimuli in Web-based experiments, with a general conclusion that accuracy is acceptable for most kinds of experiments. However, many areas of behavioral research use auditory stimuli instead of, or in addition to, visual stimuli. Much less is known about auditory accuracy using standard Web-based testing procedures. We used a millisecond-accurate Black Box Toolkit to measure the actual durations of auditory stimuli and the synchronization of auditory and visual presentation onsets. We examined the distribution of timings for 100 presentations of auditory and visual stimuli across two computers with difference specs, three commonly used browsers, and code written in either Adobe Flash or JavaScript. We also examined different coding options for attempting to synchronize the auditory and visual onsets. Overall, we found that auditory durations were very consistent, but that the lags between visual and auditory onsets varied substantially across browsers and computer systems.

  16. Pressure algorithm for elliptic flow calculations with the PDF method

    NASA Technical Reports Server (NTRS)

    Anand, M. S.; Pope, S. B.; Mongia, H. C.

    1991-01-01

    An algorithm to determine the mean pressure field for elliptic flow calculations with the probability density function (PDF) method is developed and applied. The PDF method is a most promising approach for the computation of turbulent reacting flows. Previous computations of elliptic flows with the method were in conjunction with conventional finite volume based calculations that provided the mean pressure field. The algorithm developed and described here permits the mean pressure field to be determined within the PDF calculations. The PDF method incorporating the pressure algorithm is applied to the flow past a backward-facing step. The results are in good agreement with data for the reattachment length, mean velocities, and turbulence quantities including triple correlations.

  17. A multi-scalar PDF approach for LES of turbulent spray combustion

    NASA Astrophysics Data System (ADS)

    Raman, Venkat; Heye, Colin

    2011-11-01

    A comprehensive joint-scalar probability density function (PDF) approach is proposed for large eddy simulation (LES) of turbulent spray combustion and tests are conducted to analyze the validity and modeling requirements. The PDF method has the advantage that the chemical source term appears closed but requires models for the small scale mixing process. A stable and consistent numerical algorithm for the LES/PDF approach is presented. To understand the modeling issues in the PDF method, direct numerical simulation of a spray flame at three different fuel droplet Stokes numbers and an equivalent gaseous flame are carried out. Assumptions in closing the subfilter conditional diffusion term in the filtered PDF transport equation are evaluated for various model forms. In addition, the validity of evaporation rate models in high Stokes number flows is analyzed.

  18. Interactive 3D-PDF Presentations for the Simulation and Quantification of Extended Endoscopic Endonasal Surgical Approaches.

    PubMed

    Mavar-Haramija, Marija; Prats-Galino, Alberto; Méndez, Juan A Juanes; Puigdelívoll-Sánchez, Anna; de Notaris, Matteo

    2015-10-01

    A three-dimensional (3D) model of the skull base was reconstructed from the pre- and post-dissection head CT images and embedded in a Portable Document Format (PDF) file, which can be opened by freely available software and used offline. The CT images were segmented using a specific 3D software platform for biomedical data, and the resulting 3D geometrical models of anatomical structures were used for dual purpose: to simulate the extended endoscopic endonasal transsphenoidal approaches and to perform the quantitative analysis of the procedures. The analysis consisted of bone removal quantification and the calculation of quantitative parameters (surgical freedom and exposure area) of each procedure. The results are presented in three PDF documents containing JavaScript-based functions. The 3D-PDF files include reconstructions of the nasal structures (nasal septum, vomer, middle turbinates), the bony structures of the anterior skull base and maxillofacial region and partial reconstructions of the optic nerve, the hypoglossal and vidian canals and the internal carotid arteries. Alongside the anatomical model, axial, sagittal and coronal CT images are shown. Interactive 3D presentations were created to explain the surgery and the associated quantification methods step-by-step. The resulting 3D-PDF files allow the user to interact with the model through easily available software, free of charge and in an intuitive manner. The files are available for offline use on a personal computer and no previous specialized knowledge in informatics is required. The documents can be downloaded at http://hdl.handle.net/2445/55224 .

  19. Using Adobe Flash animations of electron transport chain to teach and learn biochemistry.

    PubMed

    Teplá, Milada; Klímová, Helena

    2015-01-01

    Teaching the subject of the electron transport chain is one of the most challenging aspects of the chemistry curriculum at the high school level. This article presents an educational program called "Electron Transport Chain" which consists of 14 visual animations including a biochemistry quiz. The program was created in the Adobe Flash CS3 Professional animation program and is designed for high school chemistry students. Our goal is to develop educational materials that facilitate the comprehension of this complex subject through dynamic animations which show the course of the electron transport chain and simultaneously explain its nature. We record the process of the electron transport chain, including connections with oxidative phosphorylation, in such a way as to minimize the occurrence of discrepancies in interpretation. The educational program was evaluated in high schools through the administration of a questionnaire, which contained 12 opened-ended items and which required participants to evaluate the graphics of the animations, chemical content, student preferences, and its suitability for high school biochemistry teaching. © 2015 The International Union of Biochemistry and Molecular Biology.

  20. Natural-Color Image Mosaics of Afghanistan: Digital Databases and Maps

    USGS Publications Warehouse

    Davis, Philip A.; Hare, Trent M.

    2007-01-01

    Explanation: The 50 tiled images in this dataset are natural-color renditions of the calibrated six-band Landsat mosaics created from Landsat Enhanced Thematic Mapper Plus (ETM+) data. Natural-color images depict the surface as seen by the human eye. The calibration of the Landsat ETM+ maps produced by Davis (2006) are relative reflectance and need to be grounded with ground-reflectance data, but the difficulties in performing fieldwork in Afghanistan precluded ground-reflectance surveys. For natural color calibration, which involves only the blue, green, and red color bands of Landsat, we could use ground photographs, Munsell color readings of ground surfaces, or another image base that accurately depicts the surface color. Each map quadrangle is 1? of latitude by? of longitude. The numbers assigned to each map quadrangle refer to the latitude and longitude coordinates of the lower left corner of the quadrangle. For example, quadrangle Q2960 has its lower left corner at lat 29? N., long 60? E. Each quadrangle overlaps adjacent quadrangles by 100 pixels (2.85 km). Only the 14.25-m-spacial-resolution UTM and 28.5-m-spacial-resolution WGS84 geographic geotiff datasets are available in this report to decrease the amount of space needed. The images are (three-band, eight-bit) geotiffs with embedded georeferencing. As such, most software will not require the associated world files. An index of all available images in geographic is displayed here: Index_Geo_DD.pdf. The country of Afghanistan spans three UTM zones: (41-43). Maps are stored as geoTIFFs in their respective UTM zone projection. Indexes of all available topographic map sheets in their respective UTM zone are displayed here: Index_UTM_Z41.pdf, Index_UTM_Z42.pdf, Index_UTM_Z43.pdf. You will need Adobe Reader to view the PDF files. Download a copy of the latest version of Adobe Reader for free.

  1. PDF-modulated visual inputs and cryptochrome define diurnal behavior in Drosophila.

    PubMed

    Cusumano, Paola; Klarsfeld, André; Chélot, Elisabeth; Picot, Marie; Richier, Benjamin; Rouyer, François

    2009-11-01

    Morning and evening circadian oscillators control the bimodal activity of Drosophila in light-dark cycles. The lateral neurons evening oscillator (LN-EO) is important for promoting diurnal activity at dusk. We found that the LN-EO autonomously synchronized to light-dark cycles through either the cryptochrome (CRY) that it expressed or the visual system. In conditions in which CRY was not activated, flies depleted for pigment-dispersing factor (PDF) or its receptor lost the evening activity and displayed reversed PER oscillations in the LN-EO. Rescue experiments indicated that normal PER cycling and the presence of evening activity relied on PDF secretion from the large ventral lateral neurons and PDF receptor function in the LN-EO. The LN-EO thus integrates light inputs and PDF signaling to control Drosophila diurnal behavior, revealing a new clock-independent function for PDF.

  2. PDF Receptor Expression Reveals Direct Interactions between Circadian Oscillators in Drosophila

    PubMed Central

    Im, Seol Hee; Taghert, Paul H.

    2010-01-01

    Daily rhythms of behavior are controlled by a circuit of circadian pacemaking neurons. In Drosophila, 150 pacemakers participate in this network, and recent observations suggest the network is divisible into M and E oscillators which normally interact and synchronize. Sixteen oscillator neurons (the small and large LNvs) express a neuropeptide called pigment dispersing factor (PDF) whose signaling is often equated with M oscillator output. Given the significance of PDF signaling to numerous aspects of behavioral and molecular rhythms, determining precisely where and how signaling via the PDF receptor (PDFR) occurs is now a central question in the field. Here we show that GAL4-mediated rescue of pdfr phenotypes using a UAS-PDFR transgene is insufficient to provide complete behavioral rescue. In contrast, we describe a ~70 kB PDF receptor (pdfr) transgene which does rescue the entire pdfr circadian behavioral phenotype. The transgene is widely but heterogeneously expressed among pacemakers, and also among a limited number of non-pacemakers. Our results support an important hypothesis: the small LNv cells directly target a subset of the other crucial pacemaker neurons cells. Furthermore, expression of the transgene confirms an autocrine feedback signaling by PDF back to PDF-expressing cells. Finally, the results present an unexpected PDF receptor site: the large LNv cells appear to target a population of non-neuronal cells that resides at the base of the eye. PMID:20394051

  3. Statistical Analysis of PDF's for Na Released by Photons from Solid Surfaces

    NASA Astrophysics Data System (ADS)

    Gamborino, D.; Wurz, P.

    2018-05-01

    We analyse the adequacy of three model speed PDF's previously used to describe the desorption of Na from a solid surface either by ESD or PSD. We found that the Maxwell PDF is too wide compared to measurements and non-thermal PDF's are better suited.

  4. Our journey to digital curation of the Jeghers Medical Index

    PubMed Central

    Gawdyda, Lori; Carter, Kimbroe; Willson, Mark; Bedford, Denise

    2017-01-01

    Background Harold Jeghers, a well-known medical educator of the twentieth century, maintained a print collection of about one million medical articles from the late 1800s to the 1990s. This case study discusses how a print collection of these articles was transformed to a digital database. Case Presentation Staff in the Jeghers Medical Index, St. Elizabeth Youngstown Hospital, converted paper articles to Adobe portable document format (PDF)/A-1a files. Optical character recognition was used to obtain searchable text. The data were then incorporated into a specialized database. Lastly, articles were matched to PubMed bibliographic metadata through automation and human review. An online database of the collection was ultimately created. The collection was made part of a discovery search service, and semantic technologies have been explored as a method of creating access points. Conclusions This case study shows how a small medical library made medical writings of the nineteenth and twentieth centuries available in electronic format for historic or semantic research, highlighting the efficiencies of contemporary information technology. PMID:28670213

  5. Augmented Articles: The Future of Peer-Reviewed Publications?

    NASA Astrophysics Data System (ADS)

    Madura, Thomas Ignatius; Clementel, Nicola; Gull, Theodore R.

    2015-08-01

    The predominance of 2D figures and animations in the literature is clearly driven by the need to display data in a classic paper-journal format. However, there is no real reason that researchers should be limited to 2D graphics when presenting their results in peer-reviewed publications. This is especially true since all major astrophysical journals are now published online. So-called ‘augmented articles’ are possible, in which 3D interactive models, images, sound, and video can be included directly within an Adobe Portable Document Format (PDF) article. The inclusion of 3D interactive models in the astrophysics literature is slowly becoming popular, and several journals now fully support the inclusion of 3D interactive figures and movies. I present examples of recently published augmented articles in astronomy (e.g. Madura et al. 2015, arXiv:1503.00716) and discuss their perceived benefits and limitations. Such articles may become the norm in astronomy as data and numerical simulations increasingly become multidimensional (see http://www.technologyreview.com/view/535796/astronomers-create-3-d-printed-model-of-colliding-stellar-winds/).

  6. Our journey to digital curation of the Jeghers Medical Index.

    PubMed

    Gawdyda, Lori; Carter, Kimbroe; Willson, Mark; Bedford, Denise

    2017-07-01

    Harold Jeghers, a well-known medical educator of the twentieth century, maintained a print collection of about one million medical articles from the late 1800s to the 1990s. This case study discusses how a print collection of these articles was transformed to a digital database. Staff in the Jeghers Medical Index, St. Elizabeth Youngstown Hospital, converted paper articles to Adobe portable document format (PDF)/A-1a files. Optical character recognition was used to obtain searchable text. The data were then incorporated into a specialized database. Lastly, articles were matched to PubMed bibliographic metadata through automation and human review. An online database of the collection was ultimately created. The collection was made part of a discovery search service, and semantic technologies have been explored as a method of creating access points. This case study shows how a small medical library made medical writings of the nineteenth and twentieth centuries available in electronic format for historic or semantic research, highlighting the efficiencies of contemporary information technology.

  7. Reprocessing of multi-channel seismic-reflection data collected in the Beaufort Sea

    USGS Publications Warehouse

    Agena, W.F.; Lee, Myung W.; Hart, P.E.

    2000-01-01

    Contained on this set of two CD-ROMs are stacked and migrated multi-channel seismic-reflection data for 65 lines recorded in the Beaufort Sea by the United States Geological Survey in 1977. All data were reprocessed by the USGS using updated processing methods resulting in improved interpretability. Each of the two CD-ROMs contains the following files: 1) 65 files containing the digital seismic data in standard, SEG-Y format; 2) 1 file containing navigation data for the 65 lines in standard SEG-P1 format; 3) an ASCII text file with cross-reference information for relating the sequential trace numbers on each line to cdp numbers and shotpoint numbers; 4) 2 small scale graphic images (stacked and migrated) of a segment of line 722 in Adobe Acrobat (R) PDF format; 5) a graphic image of the location map, generated from the navigation file; 6) PlotSeis, an MS-DOS Application that allows PC users to interactively view the SEG-Y files; 7) a PlotSeis documentation file; and 8) an explanation of the processing used to create the final seismic sections (this document).

  8. AzTEC Survey of the Central Molecular Zone: Modeling Dust SEDs and N-PDF with Hierarchical Bayesian Analysis

    NASA Astrophysics Data System (ADS)

    Tang, Yuping; Wang, Daniel; Wilson, Grant; Gutermuth, Robert; Heyer, Mark

    2018-01-01

    We present the AzTEC/LMT survey of dust continuum at 1.1mm on the central ˜ 200pc (CMZ) of our Galaxy. A joint SED analysis of all existing dust continuum surveys on the CMZ is performed, from 160µm to 1.1mm. Our analysis follows a MCMC sampling strategy incorporating the knowledge of PSFs in different maps, which provides unprecedented spacial resolution on distributions of dust temperature, column density and emissivity index. The dense clumps in the CMZ typically show low dust temperature ( 20K), with no significant sign of buried star formation, and a weak evolution of higher emissivity index toward dense peak. A new model is proposed, allowing for varying dust temperature inside a cloud and self-shielding of dust emission, which leads to similar conclusions on dust temperature and grain properties. We further apply a hierarchical Bayesian analysis to infer the column density probability distribution function (N-PDF), while simultaneously removing the Galactic foreground and background emission. The N-PDF shows a steep power-law profile with α > 3, indicating that formation of dense structures are suppressed.

  9. Evaluation of the reproducibility of lung motion probability distribution function (PDF) using dynamic MRI.

    PubMed

    Cai, Jing; Read, Paul W; Altes, Talissa A; Molloy, Janelle A; Brookeman, James R; Sheng, Ke

    2007-01-21

    Treatment planning based on probability distribution function (PDF) of patient geometries has been shown a potential off-line strategy to incorporate organ motion, but the application of such approach highly depends upon the reproducibility of the PDF. In this paper, we investigated the dependences of the PDF reproducibility on the imaging acquisition parameters, specifically the scan time and the frame rate. Three healthy subjects underwent a continuous 5 min magnetic resonance (MR) scan in the sagittal plane with a frame rate of approximately 10 f s-1, and the experiments were repeated with an interval of 2 to 3 weeks. A total of nine pulmonary vessels from different lung regions (upper, middle and lower) were tracked and the dependences of their displacement PDF reproducibility were evaluated as a function of scan time and frame rate. As results, the PDF reproducibility error decreased with prolonged scans and appeared to approach equilibrium state in subjects 2 and 3 within the 5 min scan. The PDF accuracy increased in the power function with the increase of frame rate; however, the PDF reproducibility showed less sensitivity to frame rate presumably due to the randomness of breathing which dominates the effects. As the key component of the PDF-based treatment planning, the reproducibility of the PDF affects the dosimetric accuracy substantially. This study provides a reference for acquiring MR-based PDF of structures in the lung.

  10. PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila.

    PubMed

    Im, Seol Hee; Taghert, Paul H

    2010-06-01

    Daily rhythms of behavior are controlled by a circuit of circadian pacemaking neurons. In Drosophila, 150 pacemakers participate in this network, and recent observations suggest that the network is divisible into M and E oscillators, which normally interact and synchronize. Sixteen oscillator neurons (the small and large lateral neurons [LNvs]) express a neuropeptide called pigment-dispersing factor (PDF) whose signaling is often equated with M oscillator output. Given the significance of PDF signaling to numerous aspects of behavioral and molecular rhythms, determining precisely where and how signaling via the PDF receptor (PDFR) occurs is now a central question in the field. Here we show that GAL4-mediated rescue of pdfr phenotypes using a UAS-PDFR transgene is insufficient to provide complete behavioral rescue. In contrast, we describe a approximately 70-kB PDF receptor (pdfr) transgene that does rescue the entire pdfr circadian behavioral phenotype. The transgene is widely but heterogeneously expressed among pacemakers, and also among a limited number of non-pacemakers. Our results support an important hypothesis: the small LNv cells directly target a subset of the other crucial pacemaker neurons cells. Furthermore, expression of the transgene confirms an autocrine feedback signaling by PDF back to PDF-expressing cells. Finally, the results present an unexpected PDF receptor site: the large LNv cells appear to target a population of non-neuronal cells that resides at the base of the eye. (c) 2009 Wiley-Liss, Inc.

  11. Map Database for Surficial Materials in the Conterminous United States

    USGS Publications Warehouse

    Soller, David R.; Reheis, Marith C.; Garrity, Christopher P.; Van Sistine, D. R.

    2009-01-01

    The Earth's bedrock is overlain in many places by a loosely compacted and mostly unconsolidated blanket of sediments in which soils commonly are developed. These sediments generally were eroded from underlying rock, and then were transported and deposited. In places, they exceed 1000 ft (330 m) in thickness. Where the sediment blanket is absent, bedrock is either exposed or has been weathered to produce a residual soil. For the conterminous United States, a map by Soller and Reheis (2004, scale 1:5,000,000; http://pubs.usgs.gov/of/2003/of03-275/) shows these sediments and the weathered, residual material; for ease of discussion, these are referred to as 'surficial materials'. That map was produced as a PDF file, from an Adobe Illustrator-formatted version of the provisional GIS database. The provisional GIS files were further processed without modifying the content of the published map, and are here published.

  12. PDF approach for turbulent scalar field: Some recent developments

    NASA Technical Reports Server (NTRS)

    Gao, Feng

    1993-01-01

    The probability density function (PDF) method has been proven a very useful approach in turbulence research. It has been particularly effective in simulating turbulent reacting flows and in studying some detailed statistical properties generated by a turbulent field There are, however, some important questions that have yet to be answered in PDF studies. Our efforts in the past year have been focused on two areas. First, a simple mixing model suitable for Monte Carlo simulations has been developed based on the mapping closure. Secondly, the mechanism of turbulent transport has been analyzed in order to understand the recently observed abnormal PDF's of turbulent temperature fields generated by linear heat sources.

  13. Mmp1 processing of the PDF neuropeptide regulates circadian structural plasticity of pacemaker neurons.

    PubMed

    Depetris-Chauvin, Ana; Fernández-Gamba, Agata; Gorostiza, E Axel; Herrero, Anastasia; Castaño, Eduardo M; Ceriani, M Fernanda

    2014-10-01

    In the Drosophila brain, the neuropeptide PIGMENT DISPERSING FACTOR (PDF) is expressed in the small and large Lateral ventral neurons (LNvs) and regulates circadian locomotor behavior. Interestingly, PDF immunoreactivity at the dorsal terminals changes across the day as synaptic contacts do as a result of a remarkable remodeling of sLNv projections. Despite the relevance of this phenomenon to circuit plasticity and behavior, the underlying mechanisms remain poorly understood. In this work we provide evidence that PDF along with matrix metalloproteinases (Mmp1 and 2) are key in the control of circadian structural remodeling. Adult-specific downregulation of PDF levels per se hampers circadian axonal remodeling, as it does altering Mmp1 or Mmp2 levels within PDF neurons post-developmentally. However, only Mmp1 affects PDF immunoreactivity at the dorsal terminals and exerts a clear effect on overt behavior. In vitro analysis demonstrated that PDF is hydrolyzed by Mmp1, thereby suggesting that Mmp1 could directly terminate its biological activity. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  14. Mmp1 Processing of the PDF Neuropeptide Regulates Circadian Structural Plasticity of Pacemaker Neurons

    PubMed Central

    Depetris-Chauvin, Ana; Fernández-Gamba, Ágata; Gorostiza, E. Axel; Herrero, Anastasia; Castaño, Eduardo M.; Ceriani, M. Fernanda

    2014-01-01

    In the Drosophila brain, the neuropeptide PIGMENT DISPERSING FACTOR (PDF) is expressed in the small and large Lateral ventral neurons (LNvs) and regulates circadian locomotor behavior. Interestingly, PDF immunoreactivity at the dorsal terminals changes across the day as synaptic contacts do as a result of a remarkable remodeling of sLNv projections. Despite the relevance of this phenomenon to circuit plasticity and behavior, the underlying mechanisms remain poorly understood. In this work we provide evidence that PDF along with matrix metalloproteinases (Mmp1 and 2) are key in the control of circadian structural remodeling. Adult-specific downregulation of PDF levels per se hampers circadian axonal remodeling, as it does altering Mmp1 or Mmp2 levels within PDF neurons post-developmentally. However, only Mmp1 affects PDF immunoreactivity at the dorsal terminals and exerts a clear effect on overt behavior. In vitro analysis demonstrated that PDF is hydrolyzed by Mmp1, thereby suggesting that Mmp1 could directly terminate its biological activity. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior. PMID:25356918

  15. Dual PDF signaling pathways reset clocks via TIMELESS and acutely excite target neurons to control circadian behavior.

    PubMed

    Seluzicki, Adam; Flourakis, Matthieu; Kula-Eversole, Elzbieta; Zhang, Luoying; Kilman, Valerie; Allada, Ravi

    2014-03-01

    Molecular circadian clocks are interconnected via neural networks. In Drosophila, PIGMENT-DISPERSING FACTOR (PDF) acts as a master network regulator with dual functions in synchronizing molecular oscillations between disparate PDF(+) and PDF(-) circadian pacemaker neurons and controlling pacemaker neuron output. Yet the mechanisms by which PDF functions are not clear. We demonstrate that genetic inhibition of protein kinase A (PKA) in PDF(-) clock neurons can phenocopy PDF mutants while activated PKA can partially rescue PDF receptor mutants. PKA subunit transcripts are also under clock control in non-PDF DN1p neurons. To address the core clock target of PDF, we rescued per in PDF neurons of arrhythmic per⁰¹ mutants. PDF neuron rescue induced high amplitude rhythms in the clock component TIMELESS (TIM) in per-less DN1p neurons. Complete loss of PDF or PKA inhibition also results in reduced TIM levels in non-PDF neurons of per⁰¹ flies. To address how PDF impacts pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it acutely depolarizes and increases firing rates of DN1p neurons. Surprisingly, these effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence of PKA inhibition. We have provided evidence for a signaling mechanism (PKA) and a molecular target (TIM) by which PDF resets and synchronizes clocks and demonstrates an acute direct excitatory effect of PDF on target neurons to control neuronal output. The identification of TIM as a target of PDF signaling suggests it is a multimodal integrator of cell autonomous clock, environmental light, and neural network signaling. Moreover, these data reveal a bifurcation of PKA-dependent clock effects and PKA-independent output effects. Taken together, our results provide a molecular and cellular basis for the dual functions of PDF in clock resetting and pacemaker output.

  16. Dual PDF Signaling Pathways Reset Clocks Via TIMELESS and Acutely Excite Target Neurons to Control Circadian Behavior

    PubMed Central

    Seluzicki, Adam; Flourakis, Matthieu; Kula-Eversole, Elzbieta; Zhang, Luoying; Kilman, Valerie; Allada, Ravi

    2014-01-01

    Molecular circadian clocks are interconnected via neural networks. In Drosophila, PIGMENT-DISPERSING FACTOR (PDF) acts as a master network regulator with dual functions in synchronizing molecular oscillations between disparate PDF(+) and PDF(−) circadian pacemaker neurons and controlling pacemaker neuron output. Yet the mechanisms by which PDF functions are not clear. We demonstrate that genetic inhibition of protein kinase A (PKA) in PDF(−) clock neurons can phenocopy PDF mutants while activated PKA can partially rescue PDF receptor mutants. PKA subunit transcripts are also under clock control in non-PDF DN1p neurons. To address the core clock target of PDF, we rescued per in PDF neurons of arrhythmic per01 mutants. PDF neuron rescue induced high amplitude rhythms in the clock component TIMELESS (TIM) in per-less DN1p neurons. Complete loss of PDF or PKA inhibition also results in reduced TIM levels in non-PDF neurons of per01 flies. To address how PDF impacts pacemaker neuron output, we focally applied PDF to DN1p neurons and found that it acutely depolarizes and increases firing rates of DN1p neurons. Surprisingly, these effects are reduced in the presence of an adenylate cyclase inhibitor, yet persist in the presence of PKA inhibition. We have provided evidence for a signaling mechanism (PKA) and a molecular target (TIM) by which PDF resets and synchronizes clocks and demonstrates an acute direct excitatory effect of PDF on target neurons to control neuronal output. The identification of TIM as a target of PDF signaling suggests it is a multimodal integrator of cell autonomous clock, environmental light, and neural network signaling. Moreover, these data reveal a bifurcation of PKA-dependent clock effects and PKA-independent output effects. Taken together, our results provide a molecular and cellular basis for the dual functions of PDF in clock resetting and pacemaker output. PMID:24643294

  17. The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior.

    PubMed

    Lear, Bridget C; Zhang, Luoying; Allada, Ravi

    2009-07-01

    Discrete clusters of circadian clock neurons temporally organize daily behaviors such as sleep and wake. In Drosophila, a network of just 150 neurons drives two peaks of timed activity in the morning and evening. A subset of these neurons expresses the neuropeptide pigment dispersing factor (PDF), which is important for promoting morning behavior as well as maintaining robust free-running rhythmicity in constant conditions. Yet, how PDF acts on downstream circuits to mediate rhythmic behavior is unknown. Using circuit-directed rescue of PDF receptor mutants, we show that PDF targeting of just approximately 30 non-PDF evening circadian neurons is sufficient to drive morning behavior. This function is not accompanied by large changes in core molecular oscillators in light-dark, indicating that PDF RECEPTOR likely regulates the output of these cells under these conditions. We find that PDF also acts on this focused set of non-PDF neurons to regulate both evening activity phase and period length, consistent with modest resetting effects on core oscillators. PDF likely acts on more distributed pacemaker neuron targets, including the PDF neurons themselves, to regulate rhythmic strength. Here we reveal defining features of the circuit-diagram for PDF peptide function in circadian behavior, revealing the direct neuronal targets of PDF as well as its behavioral functions at those sites. These studies define a key direct output circuit sufficient for multiple PDF dependent behaviors.

  18. E AND M CIRCADIAN PACEMAKER NEURONS USE DIFFERENT PDF RECEPTOR SIGNALOSOME COMPONENTS IN DROSOPHILA

    PubMed Central

    Duvall, Laura B.

    2014-01-01

    We used real-time imaging to detect cAMP levels in neurons of intact fly brains to study mechanisms of circadian pacemaker synchronization by the neuropeptide PDF in Drosophila. PDF receptor (PDF-R) is expressed by both M (sLNv) and E (LNd) pacemaker sub-classes and is coupled to Gsα in both cases. We previously reported that PDF-R in M pacemakers elevates cAMP levels by activating the ortholog of mammalian Adenylate Cyclase 3 (AC3), but that AC3 disruptions had no effect on E pacemaker sensitivity to PDF. Here we show that PDF-R in E pacemakers activates a different AC isoform, AC78C, an ortholog of mammalian AC8. Knockdown of AC78C by transgenic RNAi substantially reduces, but does not completely abrogate, PDF responses in these E pacemakers. The knockdown effect is intact when restricted to mature stages, suggesting a physiological and not a development role for AC78C in E pacemakers. The AC78C phenotype is rescued by over-expression of AC78C, but not by over-expression of the rutabaga AC. AC78C over-expression does not disrupt PDF responses in these E pacemakers, and neither AC78C knockdown nor its over-expression disrupted locomotor rhythms. Finally, knockdown of two AKAPs, nervy and AKAP 200 partially reduces LNd PDF responses. These findings begin to identify the components of E pacemaker PDF-R signalosomes and indicate they are distinct from PDF-R signalosomes in M pacemakers: we propose they contain AC78C and at least one other AC. PMID:23929551

  19. E and M circadian pacemaker neurons use different PDF receptor signalosome components in drosophila.

    PubMed

    Duvall, Laura B; Taghert, Paul H

    2013-08-01

    We used real-time imaging to detect cAMP levels in neurons of intact fly brains to study the mechanisms of circadian pacemaker synchronization by the neuropeptide pigment dispersing factor (PDF) in Drosophila. PDF receptor (PDF-R) is expressed by both M (sLNv) and E (LNd) pacemaker subclasses and is coupled to G(sα) in both cases. We previously reported that PDF-R in M pacemakers elevates cAMP levels by activating the ortholog of mammalian adenylate cyclase 3 (AC3) but that AC3 disruptions had no effect on E pacemaker sensitivity to PDF. Here, we show that PDF-R in E pacemakers activates a different AC isoform, AC78C, an ortholog of mammalian AC8. Knockdown of AC78C by transgenic RNAi substantially reduces, but does not completely abrogate, PDF responses in these E pacemakers. The knockdown effect is intact when restricted to mature stages, suggesting a physiological and not a development role for AC78C in E pacemakers. The AC78C phenotype is rescued by the overexpression of AC78C but not by overexpression of the rutabaga AC. AC78C overexpression does not disrupt PDF responses in these E pacemakers, and neither AC78C knockdown nor its overexpression disrupted locomotor rhythms. Finally, knockdown of 2 AKAPs, nervy and AKAP200, partially reduces LNd PDF responses. These findings begin to identify the components of E pacemaker PDF-R signalosomes and indicate that they are distinct from PDF-R signalosomes in M pacemakers: we propose they contain AC78C and at least 1 other AC.

  20. PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors.

    PubMed

    Mertens, Inge; Vandingenen, Anick; Johnson, Erik C; Shafer, Orie T; Li, W; Trigg, J S; De Loof, Arnold; Schoofs, Liliane; Taghert, Paul H

    2005-10-20

    The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP. In response to PDF, the PDF receptor (PDFR) elevates cAMP levels when expressed in HEK293 cells. As predicted by in vivo studies, cotransfection of Neurofibromatosis Factor 1 significantly improves coupling of PDFR to adenylate cyclase. pdfr mutant flies display increased circadian arrhythmicity, and also display altered geotaxis that is epistatic to that of pdf mutants. PDFR immunosignals are expressed by diverse neurons, but only by a small subset of circadian pacemakers. These data establish the first synapse within the Drosophila circadian neural circuit and underscore the importance of Class II peptide GPCR signaling in circadian neural systems.

  1. An assumed joint-Beta PDF approach for supersonic turbulent combustion

    NASA Technical Reports Server (NTRS)

    Baurle, R. A.; Alexopoulos, G. A.; Hassan, H. A.; Drummond, J. P.

    1992-01-01

    In a recent experiment, Cheng et al. (1991) used ultraviolet spontaneous vibrational Raman scattering and laser-induced predissociative fluorescence techniques for simultaneous measurements of temperature and concentrations of O2, H2, H2O, OH, and N2 (and their rms) in supersonic turbulent reacting shear layers. Because present computational techniques are not suited for prediction of all of the above measurements, a new approach has been developed and is being used to predict all relevant flow properties and their rms (where appropriate). The approach explores the use of a joint-Beta PDF for concentrations. It was found that the general expression of this PDF was impractical because of decoding problems resulting from determining the various parameters of the PDF. Thus, a special case of this general expression was considered. Calculations using this simplified version of the joint-Beta PDF were not consistent with the available data from the experiment.

  2. On the link between column density distribution and density scaling relation in star formation regions

    NASA Astrophysics Data System (ADS)

    Veltchev, Todor; Donkov, Sava; Stanchev, Orlin

    2017-07-01

    We present a method to derive the density scaling relation ∝ L^{-α} in regions of star formation or in their turbulent vicinities from straightforward binning of the column-density distribution (N-pdf). The outcome of the method is studied for three types of N-pdf: power law (7/5≤α≤5/3), lognormal (0.7≲α≲1.4) and combination of lognormals. In the last case, the method of Stanchev et al. (2015) was also applied for comparison and a very weak (or close to zero) correlation was found. We conclude that the considered `binning approach' reflects rather the local morphology of the N-pdf with no reference to the physical conditions in a considered region. The rough consistency of the derived slopes with the widely adopted Larson's (1981) value α˜1.1 is suggested to support claims that the density-size relation in molecular clouds is indeed an artifact of the observed N-pdf.

  3. Blocking endocytosis in Drosophila's circadian pacemaker neurons interferes with the endogenous clock in a PDF-dependent way.

    PubMed

    Wülbeck, Corinna; Grieshaber, Eva; Helfrich-Förster, Charlotte

    2009-10-01

    The neuropeptide pigment-dispersing factor (PDF) plays an essential role in the circadian clock of the fruit fly Drosophila melanogaster, but many details of PDF signaling in the clock network are still unknown. We tried to interfere with PDF signaling by blocking the GTPase Shibire in PDF neurons. Shibire is an ortholog of the mammalian Dynamins and is essential for endocytosis of clathrin-coated vesicles at the plasma membrane. Such endocytosis is used for neurotransmitter reuptake by presynaptic neurons, which is a prerequisite of synaptic vesicle recycling, and receptor-mediated endocytosis in the postsynaptic neuron, which leads to signal termination. By blocking Shibire function via overexpression of a dominant negative mutant form of Shibire in PDF neurons, we slowed down the behavioral rhythm by 3 h. This effect was absent in PDF receptor null mutants, indicating that we interfered with PDF receptor-mediated endocytosis. Because we obtained similar behavioral phenotypes by increasing the PDF level in regions close to PDF neurons, we conclude that blocking Shibire did prolong PDF signaling in the neurons that respond to PDF. Obviously, terminating the PDF signaling via receptor-mediated endocytosis is a crucial step in determining the period of behavioral rhythms.

  4. Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila.

    PubMed

    Isaac, R Elwyn; Johnson, Erik C; Audsley, Neil; Shirras, Alan D

    2007-12-01

    Recent studies have firmly established pigment dispersing factor (PDF), a C-terminally amidated octodecapeptide, as a key neurotransmitter regulating rhythmic circadian locomotory behaviours in adult Drosophila melanogaster. The mechanisms by which PDF functions as a circadian peptide transmitter are not fully understood, however; in particular, nothing is known about the role of extracellular peptidases in terminating PDF signalling at synapses. In this study we show that PDF is susceptible to hydrolysis by neprilysin, an endopeptidase that is enriched in synaptic membranes of mammals and insects. Neprilysin cleaves PDF at the internal Ser7-Leu8 peptide bond to generate PDF1-7 and PDF8-18. Neither of these fragments were able to increase intracellular cAMP levels in HEK293 cells cotransfected with the Drosophila PDF receptor cDNA and a firefly luciferase reporter gene, confirming that such cleavage results in PDF inactivation. The Ser7-Leu8 peptide bond was also the principal cleavage site when PDF was incubated with membranes prepared from heads of adult Drosophila. This endopeptidase activity was inhibited by the neprilysin inhibitors phosphoramidon (IC(50,) 0.15 micromol l(-1)) and thiorphan (IC(50,) 1.2 micromol l(-1)). We propose that cleavage by a member of the Drosophila neprilysin family of endopeptidases is the most likely mechanism for inactivating synaptic PDF and that neprilysin might have an important role in regulating PDF signals within circadian neural circuits.

  5. Cross-reference identification within a PDF document

    NASA Astrophysics Data System (ADS)

    Li, Sida; Gao, Liangcai; Tang, Zhi; Yu, Yinyan

    2015-01-01

    Cross-references, such like footnotes, endnotes, figure/table captions, references, are a common and useful type of page elements to further explain their corresponding entities in the target document. In this paper, we focus on cross-reference identification in a PDF document, and present a robust method as a case study of identifying footnotes and figure references. The proposed method first extracts footnotes and figure captions, and then matches them with their corresponding references within a document. A number of novel features within a PDF document, i.e., page layout, font information, lexical and linguistic features of cross-references, are utilized for the task. Clustering is adopted to handle the features that are stable in one document but varied in different kinds of documents so that the process of identification is adaptive with document types. In addition, this method leverages results from the matching process to provide feedback to the identification process and further improve the algorithm accuracy. The primary experiments in real document sets show that the proposed method is promising to identify cross-reference in a PDF document.

  6. A time dependent mixing model to close PDF equations for transport in heterogeneous aquifers

    NASA Astrophysics Data System (ADS)

    Schüler, L.; Suciu, N.; Knabner, P.; Attinger, S.

    2016-10-01

    Probability density function (PDF) methods are a promising alternative to predicting the transport of solutes in groundwater under uncertainty. They make it possible to derive the evolution equations of the mean concentration and the concentration variance, used in moment methods. The mixing model, describing the transport of the PDF in concentration space, is essential for both methods. Finding a satisfactory mixing model is still an open question and due to the rather elaborate PDF methods, a difficult undertaking. Both the PDF equation and the concentration variance equation depend on the same mixing model. This connection is used to find and test an improved mixing model for the much easier to handle concentration variance. Subsequently, this mixing model is transferred to the PDF equation and tested. The newly proposed mixing model yields significantly improved results for both variance modelling and PDF modelling.

  7. Geologic map of the Fifteenmile Valley 7.5' quadrangle, San Bernardino County, California

    USGS Publications Warehouse

    Miller, F.K.; Matti, J.C.

    2001-01-01

    Open-File Report OF 01-132 contains a digital geologic map database of the Fifteenmile Valley 7.5’ quadrangle, San Bernardino County, California that includes: 1. ARC/INFO (Environmental Systems Research Institute, http://www.esri.com) version 7.2.1 coverages of the various elements of the geologic map. 2. A PostScript file to plot the geologic map on a topographic base, and containing a Correlation of Map Units diagram, a Description of Map Units, an index map, and a regional structure map. 3. Portable Document Format (.pdf) files of: a. This Readme; includes in Appendix I, data contained in fif_met.txt b. The same graphic as plotted in 2 above. (Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat pagesize setting influences map scale.) The Correlation of Map Units (CMU) and Description of Map Units (DMU) is in the editorial format of USGS Miscellaneous Investigations Series (I-series) maps. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Even though this is an author-prepared report, every attempt has been made to closely adhere to the stratigraphic nomenclature of the U. S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above). If roads in some areas, especially forest roads that parallel topographic contours, do not show well on plots of the geologic map, we recommend use of the USGS Fifteenmile Valley 7.5’ topographic quadrangle in conjunction with the geologic map.

  8. Methylation of zebularine: a quantum mechanical study incorporating interactive 3D pdf graphs.

    PubMed

    Selvam, Lalitha; Vasilyev, Vladislav; Wang, Feng

    2009-08-20

    Methylation of a cytidine deaminase inhibitor, 1-(beta-D-ribofuranosyl)-2-pyrimidone (i.e., zebularine (zeb)), which produces 1-(beta-D-ribofuranosyl)-5-methyl-2-pyrimidinone (d5), has been investigated using density functional theory models. The optimized structures of zeb and d5 and the valence orbitals primarily responsible for the methylation in d5 are presented using state-of-the-art interactive (on a computer or online) three-dimensional (3D) graphics in a portable document format (pdf) file, 3D-PDF (http://www.web3d.org/x3d/vrml/ ). The facility to embed 3D molecular structures into pdf documents has been developed jointly at Swinburne University of Technology and the National Computational Infrastructure, the Australian National University. The methyl fragment in the base moiety shows little effect on the sugar puckering but apparently affects anisotropic properties, such as condensed Fukui functions. Binding energy spectra, both valence space and core space, are noticeably affected; in particular, in the outer-valence space (e.g., IP < 20 eV). The methyl fragment delocalizes and diffuses into almost all valence space, but orbitals 8 (57a, IP = 12.57 eV), 18 (47a, IP = 14.70 eV), and 37 (28a, IP = 22.15 eV) are identified as fingerprint for the methyl fragment. In the inner shell, however, the impact of the methyl can be localized and identified by chemical shift. A small, global, red shift is found for the O-K, N-K and sugar C-K spectra, whereas the base C-K spectrum exhibits apparent methyl-related changes.

  9. Probing the Crystal Structure and Formation Mechanism of Lanthanide-Doped Upconverting Nanocrystals

    DOE PAGES

    Hudry, Damien; Abeykoon, A. M. M.; Dooryhee, E.; ...

    2016-11-23

    Lanthanide (Ln)-doped upconverting nanocrystals (UCNCs), such as NaLnF 4 (with Ln = lanthanide), constitute an important class of nanoscale materials due to their capacity to convert near-infrared photons into near-ultraviolet or visible light. Although under intense investigation for more than a decade, UCNCs have been relatively underexplored especially regarding their crystal structure and mechanisms of formation in organic media. The former is needed to explain the relationship between atomic scale structure and upconversion (UC) properties of UCNCs (i.e., local symmetry for 4f–4f transition probability, Ln 3+ distances for energy migration), while the latter is essential to finely tune the size, morphology, chemical composition, and architecture of well-defined upconverting nanostructures, which constitute the experimental levers to modify the optical properties. In this contribution, we use synchrotron-based diffraction experiments coupled to Rietveld and pair distribution function (PDF) analyses to understand the formation of NaGdF 4:Yb:Er UCNCs in organic media and to investigate their crystal structure. Our results reveal a complex mechanism of the formation of NaGdF 4:Yb:Er UCNCs based on chemical reactions involving molecular clusters and in situ-generated, crystalline sodium fluoride at high temperature. Additionally, a detailed crystallographic investigation of NaGdF 4:Yb:Er UCNCs is presented. Our Rietveld and PDF analyses show that the space group Pmore » $$\\bar{6}$$ is the one that best describes the crystal structure of NaGdF 4:Yb:Er UCNCs contrary to what has been recently proposed. Further, our Rietveld and PDF data reveal the formation of bulk-like crystal structure down to 10 nm with limited distortions. Finally, the results presented in this paper constitute an important step toward the comprehensive understanding of the underlying picture that governs UC properties of lanthanide-doped nanostructures.« less

  10. On the detection of adobe buried archaeological structures using multiscale remote sensing techniques : Piramide Naranja in Cahuachi (Peru)

    NASA Astrophysics Data System (ADS)

    Masini, N.; Rizzo, E.; Lasaponara, R.; Orefici, G.

    2009-04-01

    The detection of buried adobe structures is a crucial issue for the remote sensing (ground, aerial and satellite) applied to archaeology for the widespread of sun-dried earth as building material in several ancient civilizations in Central and Southern America, Middle East and North Africa. Moreover it is complex, due to the subtle contrast existing between the archaeological features and the surrounding, especially in arid setting, as in the case of the well know Nazca Ceremonial Centre of Cahuachi, located in the desert of Nazca (Southern Peru) . During the last two decades of excavations adobe monuments dating back from the 6th century B.C. to the 4th century A.D have been highlighted by the Centro de Estudios Arqueológicos Precolombinos (CEAP), an italian-peruvian mission directed by Giuseppe Orefici. Actually, the archaeologists are excavating and restoring the core of the Ceremonial centre where is located a great pyramid (kown as Gran Piramide). Beginning from 2007 the two institutes of CNR, IMAA and IBAM, have been involved by CEAP, in order to provide a scientific and technological support for the archaeological research. Therefore, a multi-scale approach based on the integration of aerial and satellite remote sensing with geophysical techniques was employed in order to provide data useful for archaeological excavations. The abstract refers to the last investigations performed on a mound, known as "Piramide Naranja", during the 2008. The processing of an aerial imagery time series and two QuickBird satellite images acquired in 2002 and 2005, allowed for identifying some features related to shallow and buried structures. Such features were verified by means of geophysical prospections, performed by using the magnetometric method which observed changes in the magnetic field within the first few metres beneath the subsurface detecting buried walls and anomalies linked to ceramic deposits referable to possible tombs. Finally, the integration of all data

  11. A Lagrangian mixing frequency model for transported PDF modeling

    NASA Astrophysics Data System (ADS)

    Turkeri, Hasret; Zhao, Xinyu

    2017-11-01

    In this study, a Lagrangian mixing frequency model is proposed for molecular mixing models within the framework of transported probability density function (PDF) methods. The model is based on the dissipations of mixture fraction and progress variables obtained from Lagrangian particles in PDF methods. The new model is proposed as a remedy to the difficulty in choosing the optimal model constant parameters when using conventional mixing frequency models. The model is implemented in combination with the Interaction by exchange with the mean (IEM) mixing model. The performance of the new model is examined by performing simulations of Sandia Flame D and the turbulent premixed flame from the Cambridge stratified flame series. The simulations are performed using the pdfFOAM solver which is a LES/PDF solver developed entirely in OpenFOAM. A 16-species reduced mechanism is used to represent methane/air combustion, and in situ adaptive tabulation is employed to accelerate the finite-rate chemistry calculations. The results are compared with experimental measurements as well as with the results obtained using conventional mixing frequency models. Dynamic mixing frequencies are predicted using the new model without solving additional transport equations, and good agreement with experimental data is observed.

  12. Constraints on the gluon PDF from top quark pair production at hadron colliders

    NASA Astrophysics Data System (ADS)

    Czakon, Michal; Mangano, Michelangelo L.; Mitov, Alexander; Rojo, Juan

    2013-07-01

    Using the recently derived NNLO cross sections [1], we provide NNLO+NNLL theoretical predictions for top quark pair production based on all the available NNLO PDF sets, and compare them with the most precise LHC and Tevatron data. In this comparison we study in detail the PDF uncertainty and the scale, m t and α s dependence of the theoretical predictions for each PDF set. Next, we observe that top quark pair production provides a powerful direct constraint on the gluon PDF at large x, and include Tevatron and LHC top pair data consistently into a global NNLO PDF fit. We then explore the phenomenological consequences of the reduced gluon PDF uncertainties, by showing how they can improve predictions for Beyond the Standard Model processes at the LHC. Finally, we update to full NNLO+NNLL the theoretical predictions for the ratio of top quark cross sections between different LHC center of mass energies, as well as the cross sections for hypothetical heavy fourth-generation quark production at the LHC.

  13. HAZPAC; an interactive map of Pacific Rim natural hazards, population, and infrastructure

    USGS Publications Warehouse

    Bemis, B.L.; Goss, H.V.; Yurkovich, E.S.; Perron, T.J.; Howell, D.G.

    2002-01-01

    This is an online version of a CD-ROM publication. The text files that describe using this publication make reference to software provided on the disc. For this online version the software can be downloaded for free from Adobe Systems and Environmental Systems Research Institute, Inc. (ESRI). Welcome to HAZPAC! HAZPAC is an interactive map about natural hazard risk in the Pacific Rim region. It is intended to communicate to a broad audience the ideas of 'Crowding the Rim,' which is an international, public-private partnership that fosters collaborative solutions for regional risks. HAZPAC, which stands for 'HAZards of the PACific,' uses Geographic Information System (GIS) technology to help people visualize the socioeconomic connections and shared hazard vulnerabilities among Pacific Rim countries, as well as to explore the general nature of risk. Please refer to the 'INTRODUCTION TO HAZPAC' section of the readme file below to determine which HAZPAC project will be right for you. Once you have decided which HAZPAC project is suitable for you, please refer to the 'GETTING STARTED' sections in the readme file for some basic information that will help you begin using HAZPAC. Also, we highly recommend that you follow the Tutorial exercises in the project-specific HAZPAC User Guides. The User Guides are PDF (Portable Document Format) files that must be read with Adobe Acrobat Reader (a free copy of Acrobat Reader is available using the link near the bottom of this page).

  14. PDF methods for turbulent reactive flows

    NASA Technical Reports Server (NTRS)

    Hsu, Andrew T.

    1995-01-01

    Viewgraphs are presented on computation of turbulent combustion, governing equations, closure problem, PDF modeling of turbulent reactive flows, validation cases, current projects, and collaboration with industry and technology transfer.

  15. Functional PDF Signaling in the Drosophila Circadian Neural Circuit Is Gated by Ral A-Dependent Modulation.

    PubMed

    Klose, Markus; Duvall, Laura; Li, Weihua; Liang, Xitong; Ren, Chi; Steinbach, Joe Henry; Taghert, Paul H

    2016-05-18

    The neuropeptide PDF promotes the normal sequencing of circadian behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood. We report daily rhythmicity in responsiveness to PDF in critical pacemakers called small LNvs. There is a daily change in potency, as great as 10-fold higher, around dawn. The rhythm persists in constant darkness and does not require endogenous ligand (PDF) signaling or rhythmic receptor gene transcription. Furthermore, rhythmic responsiveness reflects the properties of the pacemaker cell type, not the receptor. Dopamine responsiveness also cycles, in phase with that of PDF, in the same pacemakers, but does not cycle in large LNv. The activity of RalA GTPase in s-LNv regulates PDF responsiveness and behavioral locomotor rhythms. Additionally, cell-autonomous PDF signaling reversed the circadian behavioral effects of lowered RalA activity. Thus, RalA activity confers high PDF responsiveness, providing a daily gate around the dawn hours to promote functional PDF signaling. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Functional PDF Signaling in the Drosophila Circadian Neural Circuit is Gated by Ral A-Dependent Modulation

    PubMed Central

    Liang, Xitong; Ren, Chi; Steinbach, Joe Henry; Taghert, Paul H.

    2016-01-01

    The neuropeptide PDF promotes the normal sequencing of circadian behavioral rhythms in Drosophila, but its signaling mechanisms are not well understood. We report daily rhythmicity in responsiveness to PDF in critical pacemakers called small LNvs. There is a daily change in potency, as great as 10-fold higher, around dawn. The rhythm persists in constant darkness, does not require endogenous ligand (PDF) signaling, or rhythmic receptor gene transcription. Furthermore, rhythmic responsiveness reflects the properties of the pacemaker cell type, not the receptor. Dopamine responsiveness also cycles, in phase with that of PDF, in the same pacemakers, but does not cycle in large LNv. The activity of RalA GTPase in s-LNv regulates PDF responsiveness and behavioral locomotor rhythms. Additional, cell autonomous PDF signaling reversed the circadian behavioral effects of lowered RalA activity. Thus RalA activity confers high PDF responsiveness, providing a daily gate around the dawn hours to promote functional PDF signaling. PMID:27161526

  17. A hybrid Reynolds averaged/PDF closure model for supersonic turbulent combustion

    NASA Technical Reports Server (NTRS)

    Frankel, Steven H.; Hassan, H. A.; Drummond, J. Philip

    1990-01-01

    A hybrid Reynolds averaged/assumed pdf approach has been developed and applied to the study of turbulent combustion in a supersonic mixing layer. This approach is used to address the 'laminar-like' treatment of the thermochemical terms that appear in the conservation equations. Calculations were carried out for two experiments involving H2-air supersonic turbulent mixing. Two different forms of the pdf were implemented. In general, the results show modest improvement from previous calculations. Moreover, the results appear to be somewhat independent of the form of the assumed pdf.

  18. The CRYPTOCHROME photoreceptor gates PDF neuropeptide signaling to set circadian network hierarchy in Drosophila.

    PubMed

    Zhang, Luoying; Lear, Bridget C; Seluzicki, Adam; Allada, Ravi

    2009-12-15

    Circadian clocks in the brain are organized as coupled oscillators that integrate seasonal cues such as light and temperature to time daily behaviors. In Drosophila, the PIGMENT DISPERSING FACTOR (PDF) neuropeptide-expressing morning (M) and non-PDF evening (E) cells are coupled cell groups important for morning and evening behavior, respectively. Depending on day length, either M cells (short days) or E cells (long days) dictate both the morning and the evening phase, a phenomenon that we term network hierarchy. To examine the role of PDF in light-dark conditions, we examined flies lacking both the PDF receptor (PDFR) and the circadian photoreceptor CRYPTOCHROME (CRY). We found that subsets of E cells exhibit molecular oscillations antiphase to those of wild-type flies, single cry mutants, or single Pdfr mutants, demonstrating a potent role for PDF in light-mediated entrainment, specifically in the absence of CRY. Moreover, we find that the evening behavioral phase is more strongly reset by PDF(+) M cells in the absence of CRY. On the basis of our findings, we propose that CRY can gate PDF signaling to determine behavioral phase and network hierarchy.

  19. Adobe, rammed earth and wood: An energy-based environmental analysis of residential construction in Phoenix, Arizona

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gossen, C.L.

    1996-10-01

    More than 90% of the new single-family dwellings built in the Phoenix Metropolitan Area consists of wood frame construction. Using adobe and rammed earth as alternatives in residential wall construction are the main focus of this study. The study examines the process of home construction, concentrating on the environmental impacts of energy embodied in the four stages: extraction, transportation, construction, and operation. These four stages were applied to three prototypes built in the Phoenix Area throughout one year. The results are compared to determine which has the lowest environmental costs and most likely to benefit sustainability. The study requires amore » comparative analysis rather than a definite choice of a better prototype. The information provides assistance to the builder/designer with options about environmental impacts and the whole energy spectrum. Wherein previous research was based on performance standards of operation, one must also consider environmental impacts and externalities.« less

  20. Using the World Wide Web for GIDEP Problem Data Processing at Marshall Space Flight Center

    NASA Technical Reports Server (NTRS)

    McPherson, John W.; Haraway, Sandra W.; Whirley, J. Don

    1999-01-01

    Since April 1997, Marshall Space Flight Center has been using electronic transfer and the web to support our processing of the Government-Industry Data Exchange Program (GIDEP) and NASA ALERT information. Specific aspects include: (1) Extraction of ASCII text information from GIDEP for loading into Word documents for e-mail to ALERT actionees; (2) Downloading of GIDEP form image formats in Adobe Acrobat (.pdf) for internal storage display on the MSFC ALERT web page; (3) Linkage of stored GRDEP problem forms with summary information for access from the MSFC ALERT Distribution Summary Chart or from an html table of released MSFC ALERTs (4) Archival of historic ALERTs for reference by GIDEP ID, MSFC ID, or MSFC release date; (5) On-line tracking of ALERT response status using a Microsoft Access database and the web (6) On-line response to ALERTs from MSFC actionees through interactive web forms. The technique, benefits, effort, coordination, and lessons learned for each aspect are covered herein.

  1. GW182 controls Drosophila circadian behavior and PDF-receptor signaling.

    PubMed

    Zhang, Yong; Emery, Patrick

    2013-04-10

    The neuropeptide PDF is crucial for Drosophila circadian behavior: it keeps circadian neurons synchronized. Here, we identify GW182 as a key regulator of PDF signaling. Indeed, GW182 downregulation results in phenotypes similar to those of Pdf and Pdf-receptor (Pdfr) mutants. gw182 genetically interacts with Pdfr and cAMP signaling, which is essential for PDFR function. GW182 mediates miRNA-dependent gene silencing through its interaction with AGO1. Consistently, GW182's AGO1 interaction domain is required for GW182's circadian function. Moreover, our results indicate that GW182 modulates PDFR signaling by silencing the expression of the cAMP phosphodiesterase DUNCE. Importantly, this repression is under photic control, and GW182 activity level--which is limiting in circadian neurons--influences the responses of the circadian neural network to light. We propose that GW182's gene silencing activity functions as a rheostat for PDFR signaling and thus profoundly impacts the circadian neural network and its response to environmental inputs. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. GW182 controls Drosophila circadian behavior and PDF-Receptor signaling

    PubMed Central

    Zhang, Yong; Emery, Patrick

    2013-01-01

    The neuropeptide PDF is crucial for Drosophila circadian behavior: it keeps circadian neurons synchronized. Here, we identify GW182 as a key regulator of PDF signaling. Indeed, GW182 downregulation results in phenotypes similar to those of Pdf and Pdf-receptor (Pdfr) mutants. gw182 genetically interacts with Pdfr and cAMP signaling, which is essential for PDFR function. GW182 mediates miRNA-dependent gene silencing through its interaction with AGO1. Consistently, GW182's AGO1 interaction domain is required for GW182's circadian function. Moreover, our results indicate that GW182 modulates PDFR signaling by silencing the expression of the cAMP phosphodiesterase DUNCE. Importantly, this repression is under photic control, and GW182 activity level - which is limiting in circadian neurons - influences the responses of the circadian neural network to light. We propose that GW182's gene silencing activity functions as a rheostat for PDFR signaling, and thus profoundly impacts the circadian neural network and its response to environmental inputs. PMID:23583112

  3. Direct photon production and PDF fits reloaded

    DOE PAGES

    Campbell, John M.; Rojo, Juan; Slade, Emma; ...

    2018-06-09

    Direct photon production in hadronic collisions provides a handle on the gluon PDF by means of the QCD Compton scattering process. In this work we revisit the impact of direct photon production on a global PDF analysis, motivated by the recent availability of the next-to-next-to-leading (NNLO) calculation for this process. We demonstrate that the inclusion of NNLO QCD and leading-logarithmic electroweak corrections leads to a good quantitative agreement with the ATLAS measurements at 8 and 13 TeV, except for the most forward rapidity region in the former case. By including the ATLAS 8 TeV direct photon production data in themore » NNPDF3.1 NNLO global analysis, we assess its impact on the medium-x gluon. We also study the constraining power of the direct photon production measurements on PDF fits based on different datasets, in particular on the NNPDF3.1 no-LHC and collider-only fits. Here, we also present updated NNLO theoretical predictions for direct photon production at 13 TeV that include the constraints from the 8 TeV measurements.« less

  4. Direct photon production and PDF fits reloaded

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Campbell, John M.; Rojo, Juan; Slade, Emma

    Direct photon production in hadronic collisions provides a handle on the gluon PDF by means of the QCD Compton scattering process. In this work we revisit the impact of direct photon production on a global PDF analysis, motivated by the recent availability of the next-to-next-to-leading (NNLO) calculation for this process. We demonstrate that the inclusion of NNLO QCD and leading-logarithmic electroweak corrections leads to a good quantitative agreement with the ATLAS measurements at 8 and 13 TeV, except for the most forward rapidity region in the former case. By including the ATLAS 8 TeV direct photon production data in themore » NNPDF3.1 NNLO global analysis, we assess its impact on the medium-x gluon. We also study the constraining power of the direct photon production measurements on PDF fits based on different datasets, in particular on the NNPDF3.1 no-LHC and collider-only fits. Here, we also present updated NNLO theoretical predictions for direct photon production at 13 TeV that include the constraints from the 8 TeV measurements.« less

  5. Direct photon production and PDF fits reloaded

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Campbell, John M.; Rojo, Juan; Slade, Emma

    2018-02-08

    Direct photon production in hadronic collisions provides a handle on the gluon PDF by means of the QCD Compton scattering process. In this work we revisit the impact of direct photon production on a global PDF analysis, motivated by the recent availability of the next-to-next-to-leading (NNLO) calculation for this process. We demonstrate that the inclusion of NNLO QCD and leading-logarithmic electroweak corrections leads to a good quantitative agreement with the ATLAS measurements at 8 TeV and 13 TeV, except for the most forward rapidity region in the former case. By including the ATLAS 8 TeV direct photon production data inmore » the NNPDF3.1 NNLO global analysis, we assess its impact on the medium-x gluon. We also study the constraining power of the direct photon production measurements on PDF fits based on different datasets, in particular on the NNPDF3.1 no-LHC and collider-only fits. We also present updated NNLO theoretical predictions for direct photon production at 13 TeV that include the constraints from the 8 TeV measurements.« less

  6. Modeling of turbulent supersonic H2-air combustion with a multivariate beta PDF

    NASA Technical Reports Server (NTRS)

    Baurle, R. A.; Hassan, H. A.

    1993-01-01

    Recent calculations of turbulent supersonic reacting shear flows using an assumed multivariate beta PDF (probability density function) resulted in reduced production rates and a delay in the onset of combustion. This result is not consistent with available measurements. The present research explores two possible reasons for this behavior: use of PDF's that do not yield Favre averaged quantities, and the gradient diffusion assumption. A new multivariate beta PDF involving species densities is introduced which makes it possible to compute Favre averaged mass fractions. However, using this PDF did not improve comparisons with experiment. A countergradient diffusion model is then introduced. Preliminary calculations suggest this to be the cause of the discrepancy.

  7. Fallon, Nevada FORGE Well 21-31 Wireline Logs

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Blankenship, Doug

    Included are the following wireline logs from the Fallon FORGE Well 21-31. Ormat_Forge 21-31_8.5 inch section: FMI data in PDF and DLIS formats; MSCT data in PDF format; Pressure and Temperature data in PDF, LAS, and DLIS formats; Sonic Scanner data in PDF, DLIS, and LAS formats (LAS format contains Stoneley Slowness, Shear Slowness, and Compressional Slowness logs); Triple Combo in PDF, DLIS, and LAS formats; and USIT data in DLIS and PDF formats. Ormat_Forge_21-31_12.25 inch section: Resistivity data in PDF and LAS formats; Sonic Scanner data in PDF, DLIS, and LAS formats (LAS format contains Stoneley Slowness, Shear Slowness,more » and Compressional Slowness logs); Triple Combo in PDF and LAS formats; and Caliper data in PDF format (DLIS format for caliper data is included in the Sonic Scanner DLIS).« less

  8. A New LES/PDF Method for Computational Modeling of Turbulent Reacting Flows

    NASA Astrophysics Data System (ADS)

    Turkeri, Hasret; Muradoglu, Metin; Pope, Stephen B.

    2013-11-01

    A new LES/PDF method is developed for computational modeling of turbulent reacting flows. The open source package, OpenFOAM, is adopted as the LES solver and combined with the particle-based Monte Carlo method to solve the LES/PDF model equations. The dynamic Smagorinsky model is employed to account for the subgrid-scale motions. The LES solver is first validated for the Sandia Flame D using a steady flamelet method in which the chemical compositions, density and temperature fields are parameterized by the mean mixture fraction and its variance. In this approach, the modeled transport equations for the mean mixture fraction and the square of the mixture fraction are solved and the variance is then computed from its definition. The results are found to be in a good agreement with the experimental data. Then the LES solver is combined with the particle-based Monte Carlo algorithm to form a complete solver for the LES/PDF model equations. The in situ adaptive tabulation (ISAT) algorithm is incorporated into the LES/PDF method for efficient implementation of detailed chemical kinetics. The LES/PDF method is also applied to the Sandia Flame D using the GRI-Mech 3.0 chemical mechanism and the results are compared with the experimental data and the earlier PDF simulations. The Scientific and Technical Research Council of Turkey (TUBITAK), Grant No. 111M067.

  9. The GABAA Receptor RDL Acts in Peptidergic PDF Neurons to Promote Sleep in Drosophila

    PubMed Central

    Chung, Brian Y.; Kilman, Valerie L.; Keath, J. Russel; Pitman, Jena L.; Allada, Ravi

    2011-01-01

    SUMMARY Sleep is regulated by a circadian clock that largely times sleep and wake to occur at specific times of day and a sleep homeostat that drives sleep as a function of duration of prior wakefulness[1]. To better understand the role of the circadian clock in sleep regulation, we have been using the fruit fly Drosophila melanogaster[2]. Fruit flies display all of the core behavioral features of sleep including relative immobility, elevated arousal thresholds and homeostatic regulation[2, 3]. We assessed sleep-wake modulation by a core set of 20 circadian pacemaker neurons that express the neuropeptide PDF. We find that PDF neuron ablation, loss of pdf or its receptor pdfr results in increased sleep during the late night in light:dark (LD) conditions and more prominent increases on the first subjective day of constant darkness (DD). Flies deploy similar genetic and neurotransmitter pathways to regulate sleep as their mammalian counterparts, including GABA[4]. We find that RNAi-mediated knockdown of the GABAA receptor gene, Resistant to dieldrin (Rdl), in PDF neurons, reduced sleep consistent with a role for GABA in inhibiting PDF neuron function. Patch clamp electrophysiology reveals GABA-activated picrotoxin-sensitive chloride currents on PDF+ neurons. In addition, RDL is detectable most strongly on the large subset of PDF+ pacemaker neurons. These results suggest that GABAergic inhibition of arousal promoting PDF neurons is an important mode of sleep-wake regulation in vivo. PMID:19230663

  10. PDF neuron firing phase-shifts key circadian activity neurons in Drosophila.

    PubMed

    Guo, Fang; Cerullo, Isadora; Chen, Xiao; Rosbash, Michael

    2014-06-17

    Our experiments address two long-standing models for the function of the Drosophila brain circadian network: a dual oscillator model, which emphasizes the primacy of PDF-containing neurons, and a cell-autonomous model for circadian phase adjustment. We identify five different circadian (E) neurons that are a major source of rhythmicity and locomotor activity. Brief firing of PDF cells at different times of day generates a phase response curve (PRC), which mimics a light-mediated PRC and requires PDF receptor expression in the five E neurons. Firing also resembles light by causing TIM degradation in downstream neurons. Unlike light however, firing-mediated phase-shifting is CRY-independent and exploits the E3 ligase component CUL-3 in the early night to degrade TIM. Our results suggest that PDF neurons integrate light information and then modulate the phase of E cell oscillations and behavioral rhythms. The results also explain how fly brain rhythms persist in constant darkness and without CRY.

  11. The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila.

    PubMed

    Duvall, Laura B; Taghert, Paul H

    2012-01-01

    The neuropeptide Pigment Dispersing Factor (PDF) is essential for normal circadian function in Drosophila. It synchronizes the phases of M pacemakers, while in E pacemakers it decelerates their cycling and supports their amplitude. The PDF receptor (PDF-R) is present in both M and subsets of E cells. Activation of PDF-R stimulates cAMP increases in vitro and in M cells in vivo. The present study asks: What is the identity of downstream signaling components that are associated with PDF receptor in specific circadian pacemaker neurons? Using live imaging of intact fly brains and transgenic RNAi, we show that adenylate cyclase AC3 underlies PDF signaling in M cells. Genetic disruptions of AC3 specifically disrupt PDF responses: they do not affect other Gs-coupled GPCR signaling in M cells, they can be rescued, and they do not represent developmental alterations. Knockdown of the Drosophila AKAP-like scaffolding protein Nervy also reduces PDF responses. Flies with AC3 alterations show behavioral syndromes consistent with known roles of M pacemakers as mediated by PDF. Surprisingly, disruption of AC3 does not alter PDF responses in E cells--the PDF-R(+) LNd. Within M pacemakers, PDF-R couples preferentially to a single AC, but PDF-R association with a different AC(s) is needed to explain PDF signaling in the E pacemakers. Thus critical pathways of circadian synchronization are mediated by highly specific second messenger components. These findings support a hypothesis that PDF signaling components within target cells are sequestered into "circadian signalosomes," whose compositions differ between E and M pacemaker cell types.

  12. Galaxy clustering with photometric surveys using PDF redshift information

    DOE PAGES

    Asorey, J.; Carrasco Kind, M.; Sevilla-Noarbe, I.; ...

    2016-03-28

    Here, photometric surveys produce large-area maps of the galaxy distribution, but with less accurate redshift information than is obtained from spectroscopic methods. Modern photometric redshift (photo-z) algorithms use galaxy magnitudes, or colors, that are obtained through multi-band imaging to produce a probability density function (PDF) for each galaxy in the map. We used simulated data to study the effect of using different photo-z estimators to assign galaxies to redshift bins in order to compare their effects on angular clustering and galaxy bias measurements. We found that if we use the entire PDF, rather than a single-point (mean or mode) estimate, the deviations are less biased, especially when using narrow redshift bins. When the redshift bin widths aremore » $$\\Delta z=0.1$$, the use of the entire PDF reduces the typical measurement bias from 5%, when using single point estimates, to 3%.« less

  13. Geologic map of the Cucamonga Peak 7.5' quadrangle, San Bernardino County, California

    USGS Publications Warehouse

    Morton, D.M.; Matti, J.C.; Digital preparation by Koukladas, Catherine; Cossette, P.M.

    2001-01-01

    a. This Readme; includes in Appendix I, data contained in fif_met.txt b. The same graphic as plotted in 2 above. (Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat pagesize setting influences map scale.) The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Miscellaneous Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Even though this is an author-prepared report, every attempt has been made to closely adhere to the stratigraphic nomenclature of the U. S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above). If roads in some areas, especially forest roads that parallel topographic contours, do not show well on plots of the geologic map, we recommend use of the USGS Cucamonga Peak 7.5’ topographic quadrangle in conjunction with the geologic map.

  14. Geologic map of the Telegraph Peak 7.5' quadrangle, San Bernardino County, California

    USGS Publications Warehouse

    Morton, D.M.; Woodburne, M.O.; Foster, J.H.; Morton, Gregory; Cossette, P.M.

    2001-01-01

    a. This Readme; includes in Appendix I, data contained in fif_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat pagesize setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Miscellaneous Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Even though this is an author-prepared report, every attempt has been made to closely adhere to the stratigraphic nomenclature of the U. S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above). If roads in some areas, especially forest roads that parallel topographic contours, do not show well on plots of the geologic map, we recommend use of the USGS Telegraph Peak 7.5’ topographic quadrangle in conjunction with the geologic map.

  15. Non-Gaussian PDF Modeling of Turbulent Boundary Layer Fluctuating Pressure Excitation

    NASA Technical Reports Server (NTRS)

    Steinwolf, Alexander; Rizzi, Stephen A.

    2003-01-01

    The purpose of the study is to investigate properties of the probability density function (PDF) of turbulent boundary layer fluctuating pressures measured on the exterior of a supersonic transport aircraft. It is shown that fluctuating pressure PDFs differ from the Gaussian distribution even for surface conditions having no significant discontinuities. The PDF tails are wider and longer than those of the Gaussian model. For pressure fluctuations upstream of forward-facing step discontinuities and downstream of aft-facing step discontinuities, deviations from the Gaussian model are more significant and the PDFs become asymmetrical. Various analytical PDF distributions are used and further developed to model this behavior.

  16. Progress in the development of PDF turbulence models for combustion

    NASA Technical Reports Server (NTRS)

    Hsu, Andrew T.

    1991-01-01

    A combined Monte Carlo-computational fluid dynamic (CFD) algorithm was developed recently at Lewis Research Center (LeRC) for turbulent reacting flows. In this algorithm, conventional CFD schemes are employed to obtain the velocity field and other velocity related turbulent quantities, and a Monte Carlo scheme is used to solve the evolution equation for the probability density function (pdf) of species mass fraction and temperature. In combustion computations, the predictions of chemical reaction rates (the source terms in the species conservation equation) are poor if conventional turbulence modles are used. The main difficulty lies in the fact that the reaction rate is highly nonlinear, and the use of averaged temperature produces excessively large errors. Moment closure models for the source terms have attained only limited success. The probability density function (pdf) method seems to be the only alternative at the present time that uses local instantaneous values of the temperature, density, etc., in predicting chemical reaction rates, and thus may be the only viable approach for more accurate turbulent combustion calculations. Assumed pdf's are useful in simple problems; however, for more general combustion problems, the solution of an evolution equation for the pdf is necessary.

  17. Handling a Collection of PDF Documents

    EPA Pesticide Factsheets

    You have several options for making a large collection of PDF documents more accessible to your audience: avoid uploading altogether, use multiple document pages, and use document IDs as anchors for direct links within a document page.

  18. The Circadian Neuropeptide PDF Signals Preferentially through a Specific Adenylate Cyclase Isoform AC3 in M Pacemakers of Drosophila

    PubMed Central

    Duvall, Laura B.; Taghert, Paul H.

    2012-01-01

    The neuropeptide Pigment Dispersing Factor (PDF) is essential for normal circadian function in Drosophila. It synchronizes the phases of M pacemakers, while in E pacemakers it decelerates their cycling and supports their amplitude. The PDF receptor (PDF-R) is present in both M and subsets of E cells. Activation of PDF-R stimulates cAMP increases in vitro and in M cells in vivo. The present study asks: What is the identity of downstream signaling components that are associated with PDF receptor in specific circadian pacemaker neurons? Using live imaging of intact fly brains and transgenic RNAi, we show that adenylate cyclase AC3 underlies PDF signaling in M cells. Genetic disruptions of AC3 specifically disrupt PDF responses: they do not affect other Gs-coupled GPCR signaling in M cells, they can be rescued, and they do not represent developmental alterations. Knockdown of the Drosophila AKAP-like scaffolding protein Nervy also reduces PDF responses. Flies with AC3 alterations show behavioral syndromes consistent with known roles of M pacemakers as mediated by PDF. Surprisingly, disruption of AC3 does not alter PDF responses in E cells—the PDF-R(+) LNd. Within M pacemakers, PDF-R couples preferentially to a single AC, but PDF-R association with a different AC(s) is needed to explain PDF signaling in the E pacemakers. Thus critical pathways of circadian synchronization are mediated by highly specific second messenger components. These findings support a hypothesis that PDF signaling components within target cells are sequestered into “circadian signalosomes,” whose compositions differ between E and M pacemaker cell types. PMID:22679392

  19. Modeling Interactions Among Turbulence, Gas-Phase Chemistry, Soot and Radiation Using Transported PDF Methods

    NASA Astrophysics Data System (ADS)

    Haworth, Daniel

    2013-11-01

    The importance of explicitly accounting for the effects of unresolved turbulent fluctuations in Reynolds-averaged and large-eddy simulations of chemically reacting turbulent flows is increasingly recognized. Transported probability density function (PDF) methods have emerged as one of the most promising modeling approaches for this purpose. In particular, PDF methods provide an elegant and effective resolution to the closure problems that arise from averaging or filtering terms that correspond to nonlinear point processes, including chemical reaction source terms and radiative emission. PDF methods traditionally have been associated with studies of turbulence-chemistry interactions in laboratory-scale, atmospheric-pressure, nonluminous, statistically stationary nonpremixed turbulent flames; and Lagrangian particle-based Monte Carlo numerical algorithms have been the predominant method for solving modeled PDF transport equations. Recent advances and trends in PDF methods are reviewed and discussed. These include advances in particle-based algorithms, alternatives to particle-based algorithms (e.g., Eulerian field methods), treatment of combustion regimes beyond low-to-moderate-Damköhler-number nonpremixed systems (e.g., premixed flamelets), extensions to include radiation heat transfer and multiphase systems (e.g., soot and fuel sprays), and the use of PDF methods as the basis for subfilter-scale modeling in large-eddy simulation. Examples are provided that illustrate the utility and effectiveness of PDF methods for physics discovery and for applications to practical combustion systems. These include comparisons of results obtained using the PDF method with those from models that neglect unresolved turbulent fluctuations in composition and temperature in the averaged or filtered chemical source terms and/or the radiation heat transfer source terms. In this way, the effects of turbulence-chemistry-radiation interactions can be isolated and quantified.

  20. How to Create a Web-Ready PDF

    EPA Pesticide Factsheets

    Making EPA's PDF documents accessible (by Section 508 standards) and user-friendly includes steps such as adding bookmarks, using electronic conversion rather than scanning pages, and adding metadata.

  1. Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF.

    PubMed

    Hyun, Seogang; Lee, Youngseok; Hong, Sung-Tae; Bang, Sunhoe; Paik, Donggi; Kang, Jongkyun; Shin, Jinwhan; Lee, Jaejung; Jeon, Keunhye; Hwang, Seungyoon; Bae, Eunkyung; Kim, Jaeseob

    2005-10-20

    The pigment-dispersing factor (PDF) is a neuropeptide controlling circadian behavioral rhythms in Drosophila, but its receptor is not yet known. From a large-scale temperature preference behavior screen in Drosophila, we isolated a P insertion mutant that preferred different temperatures during the day and night. This mutation, which we named han, reduced the transcript level of CG13758. We found that Han was expressed specifically in 13 pairs of circadian clock neurons in the adult brain. han null flies showed arrhythmic circadian behavior in constant darkness. The behavioral characteristics of han null mutants were similar to those of pdf null mutants. We also found that PDF binds specifically to S2 cells expressing Han, which results in the elevation of cAMP synthesis. Therefore, we herein propose that Han is a PDF receptor regulating circadian behavioral rhythm through coordination of activities of clock neurons.

  2. Sparse PDF Volumes for Consistent Multi-Resolution Volume Rendering.

    PubMed

    Sicat, Ronell; Krüger, Jens; Möller, Torsten; Hadwiger, Markus

    2014-12-01

    This paper presents a new multi-resolution volume representation called sparse pdf volumes, which enables consistent multi-resolution volume rendering based on probability density functions (pdfs) of voxel neighborhoods. These pdfs are defined in the 4D domain jointly comprising the 3D volume and its 1D intensity range. Crucially, the computation of sparse pdf volumes exploits data coherence in 4D, resulting in a sparse representation with surprisingly low storage requirements. At run time, we dynamically apply transfer functions to the pdfs using simple and fast convolutions. Whereas standard low-pass filtering and down-sampling incur visible differences between resolution levels, the use of pdfs facilitates consistent results independent of the resolution level used. We describe the efficient out-of-core computation of large-scale sparse pdf volumes, using a novel iterative simplification procedure of a mixture of 4D Gaussians. Finally, our data structure is optimized to facilitate interactive multi-resolution volume rendering on GPUs.

  3. Sparse PDF Volumes for Consistent Multi-Resolution Volume Rendering

    PubMed Central

    Sicat, Ronell; Krüger, Jens; Möller, Torsten; Hadwiger, Markus

    2015-01-01

    This paper presents a new multi-resolution volume representation called sparse pdf volumes, which enables consistent multi-resolution volume rendering based on probability density functions (pdfs) of voxel neighborhoods. These pdfs are defined in the 4D domain jointly comprising the 3D volume and its 1D intensity range. Crucially, the computation of sparse pdf volumes exploits data coherence in 4D, resulting in a sparse representation with surprisingly low storage requirements. At run time, we dynamically apply transfer functions to the pdfs using simple and fast convolutions. Whereas standard low-pass filtering and down-sampling incur visible differences between resolution levels, the use of pdfs facilitates consistent results independent of the resolution level used. We describe the efficient out-of-core computation of large-scale sparse pdf volumes, using a novel iterative simplification procedure of a mixture of 4D Gaussians. Finally, our data structure is optimized to facilitate interactive multi-resolution volume rendering on GPUs. PMID:26146475

  4. PDF neuron firing phase-shifts key circadian activity neurons in Drosophila

    PubMed Central

    Guo, Fang; Cerullo, Isadora; Chen, Xiao; Rosbash, Michael

    2014-01-01

    Our experiments address two long-standing models for the function of the Drosophila brain circadian network: a dual oscillator model, which emphasizes the primacy of PDF-containing neurons, and a cell-autonomous model for circadian phase adjustment. We identify five different circadian (E) neurons that are a major source of rhythmicity and locomotor activity. Brief firing of PDF cells at different times of day generates a phase response curve (PRC), which mimics a light-mediated PRC and requires PDF receptor expression in the five E neurons. Firing also resembles light by causing TIM degradation in downstream neurons. Unlike light however, firing-mediated phase-shifting is CRY-independent and exploits the E3 ligase component CUL-3 in the early night to degrade TIM. Our results suggest that PDF neurons integrate light information and then modulate the phase of E cell oscillations and behavioral rhythms. The results also explain how fly brain rhythms persist in constant darkness and without CRY. DOI: http://dx.doi.org/10.7554/eLife.02780.001 PMID:24939987

  5. The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila.

    PubMed

    Chung, Brian Y; Kilman, Valerie L; Keath, J Russel; Pitman, Jena L; Allada, Ravi

    2009-03-10

    Sleep is regulated by a circadian clock that times sleep and wake to specific times of day and a homeostat that drives sleep as a function of prior wakefulness. To analyze the role of the circadian clock, we have used the fruit fly Drosophila. Flies display the core behavioral features of sleep, including relative immobility, elevated arousal thresholds, and homeostatic regulation. We assessed sleep-wake modulation by a core set of circadian pacemaker neurons that express the neuropeptide PDF. We find that disruption of PDF function increases sleep during the late night in light:dark and the first subjective day of constant darkness. Flies deploy genetic and neurotransmitter pathways to regulate sleep that are similar to those of their mammalian counterparts, including GABA. We find that RNA interference-mediated knockdown of the GABA(A) receptor gene, Resistant to dieldrin (Rdl), in PDF neurons reduces sleep, consistent with a role for GABA in inhibiting PDF neuron function. Patch-clamp electrophysiology reveals GABA-activated picrotoxin-sensitive chloride currents on PDF+ neurons. In addition, RDL is detectable most strongly on the large subset of PDF+ pacemaker neurons. These results suggest that GABAergic inhibition of arousal-promoting PDF neurons is an important mode of sleep-wake regulation in vivo.

  6. An assumed pdf approach for the calculation of supersonic mixing layers

    NASA Technical Reports Server (NTRS)

    Baurle, R. A.; Drummond, J. P.; Hassan, H. A.

    1992-01-01

    In an effort to predict the effect that turbulent mixing has on the extent of combustion, a one-equation turbulence model is added to an existing Navier-Stokes solver with finite-rate chemistry. To average the chemical-source terms appearing in the species-continuity equations, an assumed pdf approach is also used. This code was used to analyze the mixing and combustion caused by the mixing layer formed by supersonic coaxial H2-air streams. The chemistry model employed allows for the formation of H2O2 and HO2. Comparisons are made with recent measurements using laser Raman diagnostics. Comparisons include temperature and its rms, and concentrations of H2, O2, N2, H2O, and OH. In general, good agreement with experiment was noted.

  7. Research and Teaching: Exploring the Use of an Online Quiz Game to Provide Formative Feedback in a Large-Enrollment, Introductory Biochemistry Course

    ERIC Educational Resources Information Center

    Milner, Rachel; Parrish, Jonathan; Wright, Adrienne; Gnarpe, Judy; Keenan, Louanne

    2015-01-01

    In a large-enrollment, introductory biochemistry course for nonmajors, the authors provide students with formative feedback through practice questions in PDF format. Recently, they investigated possible benefits of providing the practice questions via an online game (Brainspan). Participants were randomly assigned to either the online game group…

  8. PDF methods for combustion in high-speed turbulent flows

    NASA Technical Reports Server (NTRS)

    Pope, Stephen B.

    1995-01-01

    This report describes the research performed during the second year of this three-year project. The ultimate objective of the project is extend the applicability of probability density function (pdf) methods from incompressible to compressible turbulent reactive flows. As described in subsequent sections, progress has been made on: (1) formulation and modelling of pdf equations for compressible turbulence, in both homogeneous and inhomogeneous inert flows; and (2) implementation of the compressible model in various flow configurations, namely decaying isotropic turbulence, homogeneous shear flow and plane mixing layer.

  9. PDF Signaling Is an Integral Part of the Drosophila Circadian Molecular Oscillator.

    PubMed

    Mezan, Shaul; Feuz, Jean Daniel; Deplancke, Bart; Kadener, Sebastian

    2016-10-11

    Circadian clocks generate 24-hr rhythms in physiology and behavior. Despite numerous studies, it is still uncertain how circadian rhythms emerge from their molecular and neural constituents. Here, we demonstrate a tight connection between the molecular and neuronal circadian networks. Using fluorescent transcriptional reporters in a Drosophila ex vivo brain culture system, we identified a reciprocal negative regulation between the master circadian regulator CLK and expression of pdf, the main circadian neuropeptide. We show that PDF feedback is required for maintaining normal oscillation pattern in CLK-driven transcription. Interestingly, we found that CLK and neuronal firing suppresses pdf transcription, likely through a common pathway involving the transcription factors DHR38 and SR, establishing a direct link between electric activity and the circadian system. In sum, our work provides evidence for the existence of an uncharacterized CLK-PDF feedback loop that tightly wraps together the molecular oscillator with the circadian neuronal network in Drosophila. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

  10. Anatomical characterization of PDF-tri neurons and peptidergic neurons associated with eclosion behavior in Drosophila.

    PubMed

    Selcho, Mareike; Mühlbauer, Barbara; Hensgen, Ronja; Shiga, Sakiko; Wegener, Christian; Yasuyama, Kouji

    2018-06-01

    The peptidergic Pigment-dispersing factor (PDF)-Tri neurons are a group of non-clock neurons that appear transiently around the time of adult ecdysis (=eclosion) in the fruit fly Drosophila melanogaster. This specific developmental pattern points to a function of these neurons in eclosion or other processes that are active around pupal-adult transition. As a first step to understand the role of these neurons, we here characterize the anatomy of the PDF-Tri neurons. In addition, we describe a further set of peptidergic neurons that have been associated with eclosion behavior, eclosion hormone (EH), and crustacean cardioactive peptide (CCAP) neurons, to single cell level in the pharate adult brain. PDF-Tri neurons as well as CCAP neurons co-express a classical transmitter indicated by the occurrence of small clear vesicles in addition to dense-core vesicles containing the peptides. In the tritocerebrum, gnathal ganglion and the superior protocerebrum PDF-Tri neurites contain peptidergic varicosities and both pre- and postsynaptic sites, suggesting that the PDF-Tri neurons represent modulatory rather than pure interneurons that connect the subesophageal zone with the superior protocerebrum. The extensive overlap of PDF-Tri arborizations with neurites of CCAP- and EH-expressing neurons in distinct brain regions provides anatomical evidence for a possible function of the PDF-Tri neurons in eclosion behavior. © 2018 Wiley Periodicals, Inc.

  11. Unfolding the laws of star formation: the density distribution of molecular clouds.

    PubMed

    Kainulainen, Jouni; Federrath, Christoph; Henning, Thomas

    2014-04-11

    The formation of stars shapes the structure and evolution of entire galaxies. The rate and efficiency of this process are affected substantially by the density structure of the individual molecular clouds in which stars form. The most fundamental measure of this structure is the probability density function of volume densities (ρ-PDF), which determines the star formation rates predicted with analytical models. This function has remained unconstrained by observations. We have developed an approach to quantify ρ-PDFs and establish their relation to star formation. The ρ-PDFs instigate a density threshold of star formation and allow us to quantify the star formation efficiency above it. The ρ-PDFs provide new constraints for star formation theories and correctly predict several key properties of the star-forming interstellar medium.

  12. Heat shock factors HsfB1 and HsfB2b are involved in the regulation of Pdf1.2 expression and pathogen resistance in Arabidopsis.

    PubMed

    Kumar, Mukesh; Busch, Wolfgang; Birke, Hannah; Kemmerling, Birgit; Nürnberger, Thorsten; Schöffl, Friedrich

    2009-01-01

    In order to assess the functional roles of heat stress-induced class B-heat shock factors in Arabidopsis, we investigated T-DNA knockout mutants of AtHsfB1 and AtHsfB2b. Micorarray analysis of double knockout hsfB1/hsfB2b plants revealed as strong an up-regulation of the basal mRNA-levels of the defensin genes Pdf1.2a/b in mutant plants. The Pdf expression was further enhanced by jasmonic acid treatment or infection with the necrotrophic fungus Alternaria brassicicola. The single mutant hsfB2b and the double mutant hsfB1/B2b were significantly improved in disease resistance after A. brassicicola infection. There was no indication for a direct interaction of Hsf with the promoter of Pdf1.2, which is devoid of perfect HSE consensus Hsf-binding sequences. However, changes in the formation of late HsfA2-dependent HSE binding were detected in hsfB1/B2b plants. This suggests that HsfB1/B2b may interact with class A-Hsf in regulating the shut-off of the heat shock response. The identification of Pdf genes as targets of Hsf-dependent negative regulation is the first evidence for an interconnection of Hsf in the regulation of biotic and abiotic responses.

  13. Heat Shock Factors HsfB1 and HsfB2b Are Involved in the Regulation of Pdf1.2 Expression and Pathogen Resistance in Arabidopsis

    PubMed Central

    Kumar, Mukesh; Busch, Wolfgang; Birke, Hannah; Kemmerling, Birgit; Nürnberger, Thorsten; Schöffl, Friedrich

    2009-01-01

    In order to assess the functional roles of heat stress-induced class B-heat shock factors in Arabidopsis, we investigated T-DNA knockout mutants of AtHsfB1 and AtHsfB2b. Micorarray analysis of double knockout hsfB1/hsfB2b plants revealed as strong an up-regulation of the basal mRNA-levels of the defensin genes Pdf1.2a/b in mutant plants. The Pdf expression was further enhanced by jasmonic acid treatment or infection with the necrotrophic fungus Alternaria brassicicola. The single mutant hsfB2b and the double mutant hsfB1/B2b were significantly improved in disease resistance after A. brassicicola infection. There was no indication for a direct interaction of Hsf with the promoter of Pdf1.2, which is devoid of perfect HSE consensus Hsf-binding sequences. However, changes in the formation of late HsfA2-dependent HSE binding were detected in hsfB1/B2b plants. This suggests that HsfB1/B2b may interact with class A-Hsf in regulating the shut-off of the heat shock response. The identification of Pdf genes as targets of Hsf-dependent negative regulation is the first evidence for an interconnection of Hsf in the regulation of biotic and abiotic responses. PMID:19529832

  14. A circadian neuropeptide PDF in the honeybee, Apis mellifera: cDNA cloning and expression of mRNA.

    PubMed

    Sumiyoshi, Miho; Sato, Seiji; Takeda, Yukimasa; Sumida, Kazunori; Koga, Keita; Itoh, Tsunao; Nakagawa, Hiroyuki; Shimohigashi, Yasuyuki; Shimohigashi, Miki

    2011-12-01

    Pigment-dispersing factor (PDF) is a pacemaker hormone regulating the locomotor rhythm in insects. In the present study, we cloned the cDNAs encoding the Apis PDF precursor protein, and found that there are at least seven different pdf mRNAs yielded by an alternative splicing site and five alternative polyadenylation sites in the 5'UTR and 3'UTR regions. The amino acid sequence of Apis PDF peptide has a characteristic novel amino acid residue, aspargine (Asn), at position 17. Quantitative real-time PCR of total and 5'UTR insertion-type pdf mRNAs revealed, for the first time, that the expression levels change in a circadian manner with a distinct trough at the beginning of night in LD conditions, and at the subjective night under DD conditions. In contrast, the expression level of 5'UTR deletion-type pdf mRNAs was about half of that of the insertion type, and the expression profile failed to show a circadian rhythm. As the expression profile of the total pdf mRNA exhibited a circadian rhythm, transcription regulated at the promoter region was supposed to be controlled by some of the clock components. Whole mount in situ hybridization revealed that 14 lateral neurons at the frontal margin of the optic lobe express these mRNA isoforms. PDF expressing cells examined with a newly produced antibody raised against Apis PDF were also found to have a dense supply of axon terminals in the optic lobes and the central brain.

  15. Crystal structure of an EfPDF complex with Met-Ala-Ser based on crystallographic packing.

    PubMed

    Nam, Ki Hyun; Kim, Kook-Han; Kim, Eunice Eun Kyeong; Hwang, Kwang Yeon

    2009-04-17

    PDF (peptide deformylase) plays a critical role in the production of mature proteins by removing the N-formyl polypeptide of nascent proteins in the prokaryote cell system. This protein is essential for bacterial growth, making it an attractive target for the design of new antibiotics. Accordingly, PDF has been evaluated as a drug target; however, architectural mechanism studies of PDF have not yet fully elucidated its molecular function. We recently reported the crystal structure of PDF produced by Enterococcus faecium [K.H. Nam, J.I. Ham, A. Priyadarshi, E.E. Kim, N. Chung, K.Y. Hwang, "Insight into the antibacterial drug design and architectural mechanism of peptide recognition from the E. faecium peptide deformylase structure", Proteins 74 (2009) 261-265]. Here, we present the crystal structure of the EfPDF complex with MAS (Met-Ser-Ala), thereby not only delineating the architectural mechanism for the recognition of mimic-peptides by N-terminal cleaved expression peptide, but also suggesting possible targets for rational design of antibacterial drugs. In addition to their implications for drug design, these structural studies will facilitate elucidation of the architectural mechanism responsible for the peptide recognition of PDF.

  16. Pigment-dispersing factor (PDF) has different effects on Drosophila's circadian clocks in the accessory medulla and in the dorsal brain.

    PubMed

    Wülbeck, Corinna; Grieshaber, Eva; Helfrich-Förster, Charlotte

    2008-10-01

    The neuropeptide pigment-dispersing factor (PDF) is a key transmitter in the circadian clock of Drosophila melanogaster. Here we studied the rhythmic behavior of neural mutants with modified arborizations of the large PDF neurons. In sine oculis(1) (so(1)) mutants we found a higher density of PDF fibers in the fly's pacemaker center, the accessory medulla. These flies exhibited a significantly longer period (24.6 h) than control flies. When PDF levels were elevated to very high levels in the dorsal brain as true for so(mda) mutants and small optic lobes;so(1) double mutants (sol(1);so( 1)), a short-period component split off the long period in behavioral rhythmicity. The short period became shorter the higher the amount of PDF in this brain region and reached a value of approximately 21 h. The period alterations were clearly dependent on PDF, because so(1);Pdf 01 and so(mda);Pdf 01 double mutants showed a single free-running component with a period similar to Pdf 01 mutants (approximately 22.5 h) and significantly longer than the short period of so(mda) mutants. These observations indicate that PDF feeds back on the clock neurons and changes their period. Obviously, PDF lengthens the period of some clock neurons and shortens that of others.

  17. Second Line of Defense: Electronic Maintenance Reports, Local Maintenance Provider User Guide, Rev. 3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leigh, Richard J.

    2012-09-01

    The Electronic Maintenance Report forms allow Local Maintenance Providers (LMP) and other program staff to enter maintenance information into a simple and secure system. This document describes the features and information required to complete the Maintenance Report forms. It is expected that all Corrective Maintenance Reports from LMPs will be submitted electronically into the SLD Portal. As an exception (e.g., when access to the SLD Portal is unavailable), Maintenance Reports can be submitted via a secure Adobe PDF form available through the Sustainability Manager assigned to each country.

  18. The impact of the photon PDF and electroweak corrections on [Formula: see text] distributions.

    PubMed

    Pagani, D; Tsinikos, I; Zaro, M

    2016-01-01

    We discuss the impact of EW corrections on differential distributions in top-quark pair production at the LHC and future hadron colliders, focussing on the effects of initial-state photons. Performing a calculation at Next-to-Leading Order QCD+EW accuracy, we investigate in detail the impact of photon-initiated channels on central values as well as PDF and scale uncertainties, both at order [Formula: see text] and [Formula: see text]. We present predictions at 13 and 100 TeV, and provide results for the 8 TeV differential measurements performed by ATLAS and CMS. A thorough comparison of results obtained with the NNPDF2.3QED and CT14QED PDF sets is performed. While contributions due to the photon PDF are negligible with CT14QED, this is not the case for NNPDF2.3QED, where such contributions are sizeable and show large PDF uncertainties. On the one hand, we show that differential observables in top-pair production, in particular top-quark and [Formula: see text] rapidities, can be used to improve the determination of the photon PDF within the NNPDF approach. On the other hand, with current PDF sets, we demonstrate the necessity of including EW corrections and photon-induced contributions for a correct determination of both the central value and the uncertainties of theoretical predictions.

  19. Aerial population estimates of wild horses (Equus caballus) in the adobe town and salt wells creek herd management areas using an integrated simultaneous double-count and sightability bias correction technique

    USGS Publications Warehouse

    Lubow, Bruce C.; Ransom, Jason I.

    2007-01-01

    An aerial survey technique combining simultaneous double-count and sightability bias correction methodologies was used to estimate the population of wild horses inhabiting Adobe Town and Salt Wells Creek Herd Management Areas, Wyoming. Based on 5 surveys over 4 years, we conclude that the technique produced estimates consistent with the known number of horses removed between surveys and an annual population growth rate of 16.2 percent per year. Therefore, evidence from this series of surveys supports the validity of this survey method. Our results also indicate that the ability of aerial observers to see horse groups is very strongly dependent on skill of the individual observer, size of the horse group, and vegetation cover. It is also more modestly dependent on the ruggedness of the terrain and the position of the sun relative to the observer. We further conclude that censuses, or uncorrected raw counts, are inadequate estimates of population size for this herd. Such uncorrected counts were all undercounts in our trials, and varied in magnitude from year to year and observer to observer. As of April 2007, we estimate that the population of the Adobe Town /Salt Wells Creek complex is 906 horses with a 95 percent confidence interval ranging from 857 to 981 horses.

  20. The PDF method for turbulent combustion

    NASA Technical Reports Server (NTRS)

    Pope, S. B.

    1991-01-01

    Probability Density Function (PDF) methods provide a means of calculating the properties of turbulent reacting flows. They have been successfully applied to many turbulent flames, including some with finite rate kinetic effects. Here the methods are reviewed with an emphasis on computational issues and their application to turbulent combustion.

  1. High-pressure pair distribution function (PDF) measurement using high-energy focused x-ray beam

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hong, Xinguo, E-mail: xhong@bnl.gov; Weidner, Donald J.; Ehm, Lars

    In this paper, we report recent development of the high-pressure pair distribution function (HP-PDF) measurement technique using a focused high-energy X-ray beam coupled with a diamond anvil cell (DAC). The focusing optics consist of a sagittally bent Laue monochromator and Kirkpatrick-Baez (K–B) mirrors. This combination provides a clean high-energy X-ray beam suitable for HP-PDF research. Demonstration of the HP-PDF technique for nanocrystalline platinum under quasi-hydrostatic condition above 30 GPa is presented.

  2. 77 FR 38831 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on June 4, 2012, pursuant to.... (``the Act''), 3D PDF Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with... research project. Membership in this group research project remains open, and 3D PDF intends to file...

  3. 78 FR 27431 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on April 19, 2013, pursuant to.... (``the Act''), 3D PDF Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with... project remains open, and 3D PDF intends to file additional written notifications disclosing all changes...

  4. 78 FR 72713 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-03

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on October 31, 2013, pursuant to.... (``the Act''), 3D PDF Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with... remains open, and 3D PDF intends to file additional written notifications disclosing all changes in...

  5. PDF cycling in the dorsal protocerebrum of the Drosophila brain is not necessary for circadian clock function.

    PubMed

    Kula, Elzbieta; Levitan, Edwin S; Pyza, Elzbieta; Rosbash, Michael

    2006-04-01

    In Drosophila, the neuropeptide pigment-dispersing factor (PDF) is a likely circadian molecule, secreted by central pacemaker neurons (LNvs). PDF is expressed in both small and large LNvs (sLNvs and lLNvs), and there are striking circadian oscillations of PDF staining intensity in the small cell termini, which require a functional molecular clock. This cycling may be relevant to the proposed role of PDF as a synchronizer of the clock system or as an output signal connecting pacemaker cells to locomotor activity centers. In this study, the authors use a generic neuropeptide fusion protein (atrial natriuretic factor-green fluorescent protein [ANF-GFP]) and show that it can be expressed in the same neurons as PDF itself. Yet, ANF-GFP as well as PDF itself does not manifest any cyclical accumulation in sLNv termini in adult transgenic flies. Surprisingly, the absence of detectable PDF cycling is not accompanied by any detectable behavioral pheno-type, since these transgenic flies have normal morning and evening anticipation in a light-dark cycle (LD) and are fully rhythmic in constant darkness (DD). The molecular clock is also not compromised. The results suggest that robust PDF cycling in sLNv termini plays no more than a minor role in the Drosophila circadian system and is apparently not even necessary for clock output function.

  6. Handling a Large Collection of PDF Documents

    EPA Pesticide Factsheets

    You have several options for making a large collection of PDF documents more accessible to your audience: avoid uploading altogether, use multiple document pages, and use document IDs as anchors for direct links within a document page.

  7. Exact PDF equations and closure approximations for advective-reactive transport

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Venturi, D.; Tartakovsky, Daniel M.; Tartakovsky, Alexandre M.

    2013-06-01

    Mathematical models of advection–reaction phenomena rely on advective flow velocity and (bio) chemical reaction rates that are notoriously random. By using functional integral methods, we derive exact evolution equations for the probability density function (PDF) of the state variables of the advection–reaction system in the presence of random transport velocity and random reaction rates with rather arbitrary distributions. These PDF equations are solved analytically for transport with deterministic flow velocity and a linear reaction rate represented mathematically by a heterog eneous and strongly-correlated random field. Our analytical solution is then used to investigate the accuracy and robustness of the recentlymore » proposed large-eddy diffusivity (LED) closure approximation [1]. We find that the solution to the LED-based PDF equation, which is exact for uncorrelated reaction rates, is accurate even in the presence of strong correlations and it provides an upper bound of predictive uncertainty.« less

  8. 19 CFR 351.303 - Filing, document identification, format, translation, service, and certification of documents.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... submit a public version of a database in pdf format. The public version of the database must be publicly... interested party that files with the Department a request for an expedited antidumping review, an..., whichever is later. If the interested party that files the request is unable to locate a particular exporter...

  9. 77 FR 71820 - Meeting Announcement: North American Wetlands Conservation Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    .... Written statements must be supplied to the Council Coordinator in both of the following formats: One hard copy with original signature, and one electronic copy via email (acceptable file formats are Adobe...

  10. A compound scattering pdf for the ultrasonic echo envelope and its relationship to K and Nakagami distributions.

    PubMed

    Shankar, P Mohana

    2003-03-01

    A compound probability density function (pdf) is presented to describe the envelope of the backscattered echo from tissue. This pdf allows local and global variation in scattering cross sections in tissue. The ultrasonic backscattering cross sections are assumed to be gamma distributed. The gamma distribution also is used to model the randomness in the average cross sections. This gamma-gamma model results in the compound scattering pdf for the envelope. The relationship of this compound pdf to the Rayleigh, K, and Nakagami distributions is explored through an analysis of the signal-to-noise ratio of the envelopes and random number simulations. The three parameter compound pdf appears to be flexible enough to represent envelope statistics giving rise to Rayleigh, K, and Nakagami distributions.

  11. Widespread receptivity to neuropeptide PDF throughout the neuronal circadian clock network of Drosophila revealed by real-time cyclic AMP imaging.

    PubMed

    Shafer, Orie T; Kim, Dong Jo; Dunbar-Yaffe, Richard; Nikolaev, Viacheslav O; Lohse, Martin J; Taghert, Paul H

    2008-04-24

    The neuropeptide PDF is released by sixteen clock neurons in Drosophila and helps maintain circadian activity rhythms by coordinating a network of approximately 150 neuronal clocks. Whether PDF acts directly on elements of this neural network remains unknown. We address this question by adapting Epac1-camps, a genetically encoded cAMP FRET sensor, for use in the living brain. We find that a subset of the PDF-expressing neurons respond to PDF with long-lasting cAMP increases and confirm that such responses require the PDF receptor. In contrast, an unrelated Drosophila neuropeptide, DH31, stimulates large cAMP increases in all PDF-expressing clock neurons. Thus, the network of approximately 150 clock neurons displays widespread, though not uniform, PDF receptivity. This work introduces a sensitive means of measuring cAMP changes in a living brain with subcellular resolution. Specifically, it experimentally confirms the longstanding hypothesis that PDF is a direct modulator of most neurons in the Drosophila clock network.

  12. Fluorescence circadian imaging reveals a PDF-dependent transcriptional regulation of the Drosophila molecular clock.

    PubMed

    Sabado, Virginie; Vienne, Ludovic; Nunes, José Manuel; Rosbash, Michael; Nagoshi, Emi

    2017-01-30

    Circadian locomotor behaviour is controlled by a pacemaker circuit composed of clock-containing neurons. To interrogate the mechanistic relationship between the molecular clockwork and network communication critical to the operation of the Drosophila circadian pacemaker circuit, we established new fluorescent circadian reporters that permit single-cell recording of transcriptional and post-transcriptional rhythms in brain explants and cultured neurons. Live-imaging experiments combined with pharmacological and genetic manipulations demonstrate that the neuropeptide pigment-dispersing factor (PDF) amplifies the molecular rhythms via time-of-day- and activity-dependent upregulation of transcription from E-box-containing clock gene promoters within key pacemaker neurons. The effect of PDF on clock gene transcription and the known role of PDF in enhancing PER/TIM stability occur via independent pathways downstream of the PDF receptor, the former through a cAMP-independent mechanism and the latter through a cAMP-PKA dependent mechanism. These results confirm and extend the mechanistic understanding of the role of PDF in controlling the synchrony of the pacemaker neurons. More broadly, our results establish the utility of the new live-imaging tools for the study of molecular-neural interactions important for the operation of the circadian pacemaker circuit.

  13. Fluorescence circadian imaging reveals a PDF-dependent transcriptional regulation of the Drosophila molecular clock

    PubMed Central

    Sabado, Virginie; Vienne, Ludovic; Nunes, José Manuel; Rosbash, Michael; Nagoshi, Emi

    2017-01-01

    Circadian locomotor behaviour is controlled by a pacemaker circuit composed of clock-containing neurons. To interrogate the mechanistic relationship between the molecular clockwork and network communication critical to the operation of the Drosophila circadian pacemaker circuit, we established new fluorescent circadian reporters that permit single-cell recording of transcriptional and post-transcriptional rhythms in brain explants and cultured neurons. Live-imaging experiments combined with pharmacological and genetic manipulations demonstrate that the neuropeptide pigment-dispersing factor (PDF) amplifies the molecular rhythms via time-of-day- and activity-dependent upregulation of transcription from E-box-containing clock gene promoters within key pacemaker neurons. The effect of PDF on clock gene transcription and the known role of PDF in enhancing PER/TIM stability occur via independent pathways downstream of the PDF receptor, the former through a cAMP-independent mechanism and the latter through a cAMP-PKA dependent mechanism. These results confirm and extend the mechanistic understanding of the role of PDF in controlling the synchrony of the pacemaker neurons. More broadly, our results establish the utility of the new live-imaging tools for the study of molecular-neural interactions important for the operation of the circadian pacemaker circuit. PMID:28134281

  14. The resolved star formation history of M51a through successive Bayesian marginalization

    NASA Astrophysics Data System (ADS)

    Martínez-García, Eric E.; Bruzual, Gustavo; Magris C., Gladis; González-Lópezlira, Rosa A.

    2018-02-01

    We have obtained the time and space-resolved star formation history (SFH) of M51a (NGC 5194) by fitting Galaxy Evolution Explorer (GALEX), Sloan Digital Sky Survey and near-infrared pixel-by-pixel photometry to a comprehensive library of stellar population synthesis models drawn from the Synthetic Spectral Atlas of Galaxies (SSAG). We fit for each space-resolved element (pixel) an independent model where the SFH is averaged in 137 age bins, each one 100 Myr wide. We used the Bayesian Successive Priors (BSP) algorithm to mitigate the bias in the present-day spatial mass distribution. We test BSP with different prior probability distribution functions (PDFs); this exercise suggests that the best prior PDF is the one concordant with the spatial distribution of the stellar mass as inferred from the near-infrared images. We also demonstrate that varying the implicit prior PDF of the SFH in SSAG does not affect the results. By summing the contributions to the global star formation rate of each pixel, at each age bin, we have assembled the resolved SFH of the whole galaxy. According to these results, the star formation rate of M51a was exponentially increasing for the first 10 Gyr after the big bang, and then turned into an exponentially decreasing function until the present day. Superimposed, we find a main burst of star formation at t ≈ 11.9 Gyr after the big bang.

  15. Characterization of PDF-immunoreactive neurons in the optic lobe and cerebral lobe of the cricket, Gryllus bimaculatus.

    PubMed

    Abdelsalam, Salaheldin; Uemura, Hiroyuki; Umezaki, Yujiro; Saifullah, A S M; Shimohigashi, Miki; Tomioka, Kenji

    2008-07-01

    Pigment-dispersing factor (PDF) is a neuropeptide playing important roles in insect circadian systems. In this study, we morphologically and physiologically characterized PDF-immunoreactive neurons in the optic lobe and the brain of the cricket Gryllus bimaculatus. PDF-immunoreactivity was detected in cells located in the proximal medulla (PDFMe cells) and those in the dorsal and ventral regions of the outer chiasma (PDFLa cells). The PDFMe cells had varicose processes spread over the frontal surface of the medulla and the PDFLa cells had varicose mesh-like innervations in almost whole lamina, suggesting their modulatory role in the optic lobe. Some of PDFMe cells had a hairpin-shaped axonal process running toward the lamina then turning back to project into the brain where they terminated at various protocerebral areas. The PDFMe cells had a low frequency spontaneous spike activity that was higher during the night and was often slightly increased by light pulses. Six pairs of PDF-immunoreactive neurons were also found in the frontal ganglion. Competitive ELISA with anti-PDF antibodies revealed daily cycling of PDF both in the optic lobe and cerebral lobe with an increase during the night that persisted in constant darkness. The physiological role of PDF is discussed based on these results.

  16. Understanding the Formation of Kinetically Stable Compounds and the Development of Thin Film Pair Distribution Function Analysis

    NASA Astrophysics Data System (ADS)

    Wood, Suzannah Rebecca

    Navigating the synthesis landscape poses many challenges when developing novel solid state materials. Advancements in both synthesis and characterization are necessary to facilitate the targeting of specific materials. This dissertation discusses the formation of chalcogenide heterostructures and their properties in the first part and the development of thin film pair distribution function analysis (tfPDF) in the second part. The heterostructures were formed by the self-assembly of designed precursors deposited by physical vapor deposition in a modulated elemental reactants approach, which provides the control and predictability to synthesis. Specifically, a series of (BiSe)1+delta(TiSe2) n, where n = 2,3,&4, were synthesized to explore the extent of charge transfer from the BiSe to TiSe2 layers. To further explore the role Bi plays in charge donation, a family of structurally similar compounds, (Bix Sn1-xSe)1+deltaTiSe2, where 0≥x≥1, were synthesized and characterized. Electrical measurements show doping efficiency decreases as x increases, correlated with the structural distortion and the formation of periodic antiphase boundaries containing Bi-Bi pairs. The first heterostructures composed of three unique structural types were synthesized and Bi2Se3 layer thickness was used to tune electrical properties and further explore charge transfer. To better understand the potential energy landscape on which these kinetically stable compounds exist, two investigations were undertaken. The first was a study of the formation and subsequent decomposition of [(BiSe)1+delta]n(TiSe2)n compounds, where n= 2&3, the second an investigation of precursor structure for thermodynamically stable FeSb2 and kinetically stable FeSb3. The second section describes the development of thin film pair distribution function analysis, a technique in which total scattering data for pair distribution function (PDF) analysis is obtained from thin films, suitable for local structure analysis

  17. Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals.

    PubMed

    Pereira-Castro, Isabel; Quental, Rita; da Costa, Luís T; Amorim, António; Azevedo, Luisa

    2012-02-01

    Although gene-free areas compose the great majority of eukaryotic genomes, a significant fraction of genes overlaps, i.e., unique nucleotide sequences are part of more than one transcription unit. In this work, the evolutionary history and origin of a same-strand gene overlap is dissected through the analysis of COG8 (component of oligomeric Golgi complex 8) and PDF (peptide deformylase). Comparative genomic surveys reveal that the relative locations of these two genes have been changing over the last 445 million years from distinct chromosomal locations in fish to overlapping in rodents and primates, indicating that the overlap between these genes precedes their divergence. The overlap between the two genes was initiated by the gain of a novel splice donor site between the COG8 stop codon and PDF initiation codon. Splicing is accomplished by the use of the PDF acceptor, leading COG8 to share the 3'end with PDF. In primates, loss of the ancestral polyadenylation signal for COG8 makes the overlap between COG8 and PDF mandatory, while in mouse and rat concurrent overlapping and non-overlapping Cog8 transcripts exist. Altogether, we demonstrate that the origin, evolution and preservation of the COG8/PDF same-strand overlap follow similar mechanistic steps as those documented for antisense overlaps where gain and/or loss of splice sites and polyadenylation signals seems to drive the process.

  18. Historical files from Federal government mineral exploration-assistance programs, 1950 to 1974

    USGS Publications Warehouse

    Frank, David G.

    2010-01-01

    Congress enacted the Defense Production Act in 1950 to provide funding and support for the exploration and development of critical mineral resources. From 1950 to 1974, three Department of the Interior agencies carried out this mission. Contracts with mine owners provided financial assistance for mineral exploration on a joint-participation basis. These contracts are documented in more than 5,000 'dockets' now archived online by the U.S. Geological Survey. This archive provides access to unique and difficult to recreate information, such as drill logs, assay results, and underground geologic maps, that is invaluable to land and resource management organizations and the minerals industry. An effort to preserve the data began in 2009, and the entire collection of dockets was electronically scanned. The scanning process used optical character recognition (OCR) when possible, and files were converted into Portable Document Format (.pdf) files, which require Adobe Reader or similar software for viewing. In 2010, the scans were placed online (http://minerals.usgs.gov/dockets/) and are available to download free of charge.

  19. E-library Implementation in Library University of Riau

    NASA Astrophysics Data System (ADS)

    Yuhelmi; Rismayeti

    2017-12-01

    This research aims to see how the e-book implementation in Library University of Riau and the obstacle in its implementation. In the Globalization era, digital libraries should be developed or else it will decrease the readers’ interest, with the recent advanced technology, digital libraries are one of the learning tools that can be used to finding an information through the internet access, hence digital libraries or commonly known as E-Library is really helping the students and academic community in finding information. The methods that used in this research is Observation, Interview, and Literature Study. The respondents in this research are the staff who involved in the process of digitization in Library University of Riau. The result of this research shows that implementation of e-library in Library University of Riau is already filled the user needs for now, although there is obstacle faced just like technical problems for example the internet connection speed and the technical problem to convert the format from Microsoft Word .doc to Adobe.pdf

  20. APFEL: A PDF evolution library with QED corrections

    NASA Astrophysics Data System (ADS)

    Bertone, Valerio; Carrazza, Stefano; Rojo, Juan

    2014-06-01

    Quantum electrodynamics and electroweak corrections are important ingredients for many theoretical predictions at the LHC. This paper documents APFEL, a new PDF evolution package that allows for the first time to perform DGLAP evolution up to NNLO in QCD and to LO in QED, in the variable-flavor-number scheme and with either pole or MS bar heavy quark masses. APFEL consistently accounts for the QED corrections to the evolution of quark and gluon PDFs and for the contribution from the photon PDF in the proton. The coupled QCD ⊗ QED equations are solved in x-space by means of higher order interpolation, followed by Runge-Kutta solution of the resulting discretized evolution equations. APFEL is based on an innovative and flexible methodology for the sequential solution of the QCD and QED evolution equations and their combination. In addition to PDF evolution, APFEL provides a module that computes Deep-Inelastic Scattering structure functions in the FONLL general-mass variable-flavor-number scheme up to O(αs2) . All the functionalities of APFEL can be accessed via a Graphical User Interface, supplemented with a variety of plotting tools for PDFs, parton luminosities and structure functions. Written in FORTRAN 77, APFEL can also be used via the C/C++ and Python interfaces, and is publicly available from the HepForge repository.

  1. Disk diffusion quality control guidelines for NVP-PDF 713: a novel peptide deformylase inhibitor.

    PubMed

    Anderegg, Tamara R; Jones, Ronald N

    2004-01-01

    NVP-PDF713 is a peptide deformylase inhibitor that has emerged as a candidate for treating Gram-positive infections and selected Gram-negative species that commonly cause community-acquired respiratory tract infections. This report summarizes the results of a multi-center (seven participants) disk diffusion quality control (QC) investigation for NVP PDF-713 using guidelines of the National Committee for Clinical Laboratory Standards and the standardized disk diffusion method. A total of 420 NVP-PDF 713 zone diameter values were generated for each QC organism. The proposed zone diameter ranges contained 97.6-99.8% of the reported participant results and were: Staphylococcus aureus ATCC 25923 (25-35 mm), Streptococcus pneumoniae ATCC 49619 (30-37 mm), and Haemophilus influenzae ATCC 49247 (24-32 mm). These QC criteria for the disk diffusion method should be applied during the NVP-PDF 713 clinical trials to maximize test accuracy.

  2. Evaluation of a Consistent LES/PDF Method Using a Series of Experimental Spray Flames

    NASA Astrophysics Data System (ADS)

    Heye, Colin; Raman, Venkat

    2012-11-01

    A consistent method for the evolution of the joint-scalar probability density function (PDF) transport equation is proposed for application to large eddy simulation (LES) of turbulent reacting flows containing evaporating spray droplets. PDF transport equations provide the benefit of including the chemical source term in closed form, however, additional terms describing LES subfilter mixing must be modeled. The recent availability of detailed experimental measurements provide model validation data for a wide range of evaporation rates and combustion regimes, as is well-known to occur in spray flames. In this work, the experimental data will used to investigate the impact of droplet mass loading and evaporation rates on the subfilter scalar PDF shape in comparison with conventional flamelet models. In addition, existing model term closures in the PDF transport equations are evaluated with a focus on their validity in the presence of regime changes.

  3. Effect of chemistry and turbulence on NO formation in oxygen-natural gas flames

    NASA Technical Reports Server (NTRS)

    Samaniego, J. -M.; Egolfopoulos, F. N.; Bowman, C. T.

    1996-01-01

    The effects of chemistry and turbulence on NO formation in oxygen-natural turbulent diffusion flames gas flames have been investigated. The chemistry of nitric oxides has been studied numerically in the counterflow configuration. Systematic calculations with the GRI 2.11 mechanism for combustion of methane and NO chemistry were conducted to provide a base case. It was shown that the 'simple' Zeldovich mechanism accounts for more than 75% of N2 consumption in the flame in a range of strain-rates varying between 10 and 1000 s-l. The main shortcomings of this mechanism are: 1) overestimation (15%) of the NO production rate at low strain-rates because it does not capture the reburn due to the hydrocarbon chemistry, and 2) underestimation (25%) of the NO production rate at high strainrates because it ignores NO production through the prompt mechanism. Reburn through the Zeldovich mechanism alone proves to be significant at low strain-rates. A one-step model based on the Zeldovich mechanism and including reburn has been developed. It shows good agreement with the GRI mechanism at low strain-rates but underestimates significantly N2 consumption (about 50%) at high strain-rates. The role of turbulence has been assessed by using an existing 3-D DNS data base of a diffusion flame in decaying turbulence. Two PDF closure models used in practical industrial codes for turbulent NO formation have been tested. A simpler version of the global one-step chemical scheme for NO compared to that developed in this study was used to test the closure assumptions of the PDF models, because the data base could not provide all the necessary ingredients. Despite this simplification, it was possible to demonstrate that the current PDF models for NO overestimate significantly the NO production rate due to the fact that they neglect the correlations between the fluctuations in oxygen concentration and temperature. A single scalar PDF model for temperature that accounts for such correlations based

  4. PDF investigations of turbulent non-premixed jet flames with thin reaction zones

    NASA Astrophysics Data System (ADS)

    Wang, Haifeng; Pope, Stephen

    2012-11-01

    PDF (probability density function) modeling studies are carried out for the Sydney piloted jet flames. These Sydney flames feature much thinner reaction zones in the mixture fraction space compared to those in the well-studied Sandia piloted jet flames. The performance of the different turbulent combustion models in the Sydney flames with thin reaction zones has not been examined extensively before, and this work aims at evaluating the capability of the PDF method to represent the thin turbulent flame structures in the Sydney piloted flames. Parametric and sensitivity PDF studies are performed with respect to the different models and model parameters. A global error parameter is defined to quantify the departure of the simulation results from the experimental data, and is used to assess the performance of the different set of models and model parameters.

  5. Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF.

    PubMed

    Chen, Jiangtian; Reiher, Wencke; Hermann-Luibl, Christiane; Sellami, Azza; Cognigni, Paola; Kondo, Shu; Helfrich-Förster, Charlotte; Veenstra, Jan A; Wegener, Christian

    2016-09-01

    Feeding and sleep are fundamental behaviours with significant interconnections and cross-modulations. The circadian system and peptidergic signals are important components of this modulation, but still little is known about the mechanisms and networks by which they interact to regulate feeding and sleep. We show that specific thermogenetic activation of peptidergic Allatostatin A (AstA)-expressing PLP neurons and enteroendocrine cells reduces feeding and promotes sleep in the fruit fly Drosophila. The effects of AstA cell activation are mediated by AstA peptides with receptors homolog to galanin receptors subserving similar and apparently conserved functions in vertebrates. We further identify the PLP neurons as a downstream target of the neuropeptide pigment-dispersing factor (PDF), an output factor of the circadian clock. PLP neurons are contacted by PDF-expressing clock neurons, and express a functional PDF receptor demonstrated by cAMP imaging. Silencing of AstA signalling and continuous input to AstA cells by tethered PDF changes the sleep/activity ratio in opposite directions but does not affect rhythmicity. Taken together, our results suggest that pleiotropic AstA signalling by a distinct neuronal and enteroendocrine AstA cell subset adapts the fly to a digestive energy-saving state which can be modulated by PDF.

  6. Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF

    PubMed Central

    Reiher, Wencke; Hermann-Luibl, Christiane; Sellami, Azza; Cognigni, Paola; Helfrich-Förster, Charlotte; Veenstra, Jan A.

    2016-01-01

    Feeding and sleep are fundamental behaviours with significant interconnections and cross-modulations. The circadian system and peptidergic signals are important components of this modulation, but still little is known about the mechanisms and networks by which they interact to regulate feeding and sleep. We show that specific thermogenetic activation of peptidergic Allatostatin A (AstA)-expressing PLP neurons and enteroendocrine cells reduces feeding and promotes sleep in the fruit fly Drosophila. The effects of AstA cell activation are mediated by AstA peptides with receptors homolog to galanin receptors subserving similar and apparently conserved functions in vertebrates. We further identify the PLP neurons as a downstream target of the neuropeptide pigment-dispersing factor (PDF), an output factor of the circadian clock. PLP neurons are contacted by PDF-expressing clock neurons, and express a functional PDF receptor demonstrated by cAMP imaging. Silencing of AstA signalling and continuous input to AstA cells by tethered PDF changes the sleep/activity ratio in opposite directions but does not affect rhythmicity. Taken together, our results suggest that pleiotropic AstA signalling by a distinct neuronal and enteroendocrine AstA cell subset adapts the fly to a digestive energy-saving state which can be modulated by PDF. PMID:27689358

  7. The pdf approach to turbulent polydispersed two-phase flows

    NASA Astrophysics Data System (ADS)

    Minier, Jean-Pierre; Peirano, Eric

    2001-10-01

    The purpose of this paper is to develop a probabilistic approach to turbulent polydispersed two-phase flows. The two-phase flows considered are composed of a continuous phase, which is a turbulent fluid, and a dispersed phase, which represents an ensemble of discrete particles (solid particles, droplets or bubbles). Gathering the difficulties of turbulent flows and of particle motion, the challenge is to work out a general modelling approach that meets three requirements: to treat accurately the physically relevant phenomena, to provide enough information to address issues of complex physics (combustion, polydispersed particle flows, …) and to remain tractable for general non-homogeneous flows. The present probabilistic approach models the statistical dynamics of the system and consists in simulating the joint probability density function (pdf) of a number of fluid and discrete particle properties. A new point is that both the fluid and the particles are included in the pdf description. The derivation of the joint pdf model for the fluid and for the discrete particles is worked out in several steps. The mathematical properties of stochastic processes are first recalled. The various hierarchies of pdf descriptions are detailed and the physical principles that are used in the construction of the models are explained. The Lagrangian one-particle probabilistic description is developed first for the fluid alone, then for the discrete particles and finally for the joint fluid and particle turbulent systems. In the case of the probabilistic description for the fluid alone or for the discrete particles alone, numerical computations are presented and discussed to illustrate how the method works in practice and the kind of information that can be extracted from it. Comments on the current modelling state and propositions for future investigations which try to link the present work with other ideas in physics are made at the end of the paper.

  8. Serotonin and the Neuropeptide PDF Initiate and Extend Opposing Behavioral States in C. elegans

    PubMed Central

    Flavell, Steven W.; Pokala, Navin; Macosko, Evan Z.; Albrecht, Dirk R.; Larsch, Johannes; Bargmann, Cornelia I.

    2013-01-01

    SUMMARY Foraging animals have distinct exploration and exploitation behaviors that are organized into discrete behavioral states. Here we characterize a neuromodulatory circuit that generates long-lasting roaming and dwelling states in Caenorhabditis elegans. We find that two opposing neuromodulators, serotonin and the neuropeptide pigment dispersing factor (PDF), each initiate and extend one behavioral state. Serotonin promotes dwelling states through the MOD-1 serotonin-gated chloride channel. The spontaneous activity of serotonergic neurons correlates with dwelling behavior, and optogenetic modulation of the critical MOD-1-expressing targets induces prolonged dwelling states. PDF promotes roaming states through a Gαs-coupled PDF receptor; optogenetic activation of cAMP production in PDF receptor-expressing cells induces prolonged roaming states. The neurons that produce and respond to each neuromodulator form a distributed circuit orthogonal to the classical wiring diagram, with several essential neurons that express each molecule. The slow temporal dynamics of this neuromodulatory circuit supplement fast motor circuits to organize long-lasting behavioral states. PMID:23972393

  9. Vertical overlap of probability density functions of cloud and precipitation hydrometeors: CLOUD AND PRECIPITATION PDF OVERLAP

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ovchinnikov, Mikhail; Lim, Kyo-Sun Sunny; Larson, Vincent E.

    Coarse-resolution climate models increasingly rely on probability density functions (PDFs) to represent subgrid-scale variability of prognostic variables. While PDFs characterize the horizontal variability, a separate treatment is needed to account for the vertical structure of clouds and precipitation. When sub-columns are drawn from these PDFs for microphysics or radiation parameterizations, appropriate vertical correlations must be enforced via PDF overlap specifications. This study evaluates the representation of PDF overlap in the Subgrid Importance Latin Hypercube Sampler (SILHS) employed in the assumed PDF turbulence and cloud scheme called the Cloud Layers Unified By Binormals (CLUBB). PDF overlap in CLUBB-SILHS simulations of continentalmore » and tropical oceanic deep convection is compared with overlap of PDF of various microphysics variables in cloud-resolving model (CRM) simulations of the same cases that explicitly predict the 3D structure of cloud and precipitation fields. CRM results show that PDF overlap varies significantly between different hydrometeor types, as well as between PDFs of mass and number mixing ratios for each species, - a distinction that the current SILHS implementation does not make. In CRM simulations that explicitly resolve cloud and precipitation structures, faster falling species, such as rain and graupel, exhibit significantly higher coherence in their vertical distributions than slow falling cloud liquid and ice. These results suggest that to improve the overlap treatment in the sub-column generator, the PDF correlations need to depend on hydrometeor properties, such as fall speeds, in addition to the currently implemented dependency on the turbulent convective length scale.« less

  10. Combined PDF and Rietveld studies of ADORable zeolites and the disordered intermediate IPC-1P.

    PubMed

    Morris, Samuel A; Wheatley, Paul S; Položij, Miroslav; Nachtigall, Petr; Eliášová, Pavla; Čejka, Jiří; Lucas, Tim C; Hriljac, Joseph A; Pinar, Ana B; Morris, Russell E

    2016-09-28

    The disordered intermediate of the ADORable zeolite UTL has been structurally confirmed using the pair distribution function (PDF) technique. The intermediate, IPC-1P, is a disordered layered compound formed by the hydrolysis of UTL in 0.1 M hydrochloric acid solution. Its structure is unsolvable by traditional X-ray diffraction techniques. The PDF technique was first benchmarked against high-quality synchrotron Rietveld refinements of IPC-2 (OKO) and IPC-4 (PCR) - two end products of IPC-1P condensation that share very similar structural features. An IPC-1P starting model derived from density functional theory was used for the PDF refinement, which yielded a final fit of Rw = 18% and a geometrically reasonable structure. This confirms the layers do stay intact throughout the ADOR process and shows PDF is a viable technique for layered zeolite structure determination.

  11. Structural reconstruction of the catalytic center of LiPDF through multiple scattering calculation with MXAN

    NASA Astrophysics Data System (ADS)

    Guo, Xiaoyun; Chu, Wangsheng; Ma, Sixuan; Gong, Weimin; Benfatto, Maurizio; Hu, Tiandou; Xie, Yaning; Wu, ZiYu

    2006-11-01

    Peptide deformylase (PDF, EC 3.5.1.27) is essential for the normal growth of eubacterium but not for mammalians. Recently, PDF has been studied as a target for new antibiotics. In this paper, X-ray absorption spectroscopy was employed to determine the local structure around the zinc ion of PDF from Leptospira Interrogans in dry powder, because it is very difficult to obtain the crystallized sample of LiPDF. We performed X-ray absorption near edge structure (XANES) calculation and reconstructed successfully the local geometry of the active center, and the results from calculations show that a water molecule (Wat1) has moved towards the zinc ion and lies in the distance range to coordinate with the zinc ion weakly. In addition, the sensitivity of theoretical spectra to the different ligand bodies was evaluated in terms of goodness-of-fit.

  12. EUPDF: An Eulerian-Based Monte Carlo Probability Density Function (PDF) Solver. User's Manual

    NASA Technical Reports Server (NTRS)

    Raju, M. S.

    1998-01-01

    EUPDF is an Eulerian-based Monte Carlo PDF solver developed for application with sprays, combustion, parallel computing and unstructured grids. It is designed to be massively parallel and could easily be coupled with any existing gas-phase flow and spray solvers. The solver accommodates the use of an unstructured mesh with mixed elements of either triangular, quadrilateral, and/or tetrahedral type. The manual provides the user with the coding required to couple the PDF code to any given flow code and a basic understanding of the EUPDF code structure as well as the models involved in the PDF formulation. The source code of EUPDF will be available with the release of the National Combustion Code (NCC) as a complete package.

  13. The study of PDF turbulence models in combustion

    NASA Technical Reports Server (NTRS)

    Hsu, Andrew T.

    1991-01-01

    In combustion computations, it is known that the predictions of chemical reaction rates are poor if conventional turbulence models are used. The probability density function (pdf) method seems to be the only alternative that uses local instantaneous values of the temperature, density, etc., in predicting chemical reaction rates, and thus is the only viable approach for more accurate turbulent combustion calculations. The fact that the pdf equation has a very large dimensionality renders finite difference schemes extremely demanding on computer memories and thus impractical. A logical alternative is the Monte Carlo scheme. Since CFD has a certain maturity as well as acceptance, it seems that the use of a combined CFD and Monte Carlo scheme is more beneficial. Therefore, a scheme is chosen that uses a conventional CFD flow solver in calculating the flow field properties such as velocity, pressure, etc., while the chemical reaction part is solved using a Monte Carlo scheme. The discharge of a heated turbulent plane jet into quiescent air was studied. Experimental data for this problem shows that when the temperature difference between the jet and the surrounding air is small, buoyancy effect can be neglected and the temperature can be treated as a passive scalar. The fact that jet flows have a self-similar solution lends convenience in the modeling study. Futhermore, the existence of experimental data for turbulent shear stress and temperature variance make the case ideal for the testing of pdf models wherein these values can be directly evaluated.

  14. Preliminary geologic map of the Fontana 7.5' quadrangle, Riverside and San Bernardino Counties, California

    USGS Publications Warehouse

    Morton, Douglas M.; Digital preparation by Bovard, Kelly R.

    2003-01-01

    Open-File Report 03-418 is a digital geologic data set that maps and describes the geology of the Fontana 7.5’ quadrangle, Riverside and San Bernardino Counties, California. The Fontana quadrangle database is one of several 7.5’ quadrangle databases that are being produced by the Southern California Areal Mapping Project (SCAMP). These maps and databases are, in turn, part of the nation-wide digital geologic map coverage being developed by the National Cooperative Geologic Map Program of the U.S. Geological Survey (USGS). General Open-File Report 03-418 contains a digital geologic map database of the Fontana 7.5’ quadrangle, Riverside and San Bernardino Counties, California that includes: 1. ARC/INFO (Environmental Systems Research Institute, http://www.esri.com) version 7.2.1 coverages of the various elements of the geologic map. 2. A Postscript file (fon_map.ps) to plot the geologic map on a topographic base, and containing a Correlation of Map Units diagram (CMU), a Description of Map Units (DMU), and an index map. 3. An Encapsulated PostScript (EPS) file (fon_grey.eps) created in Adobe Illustrator 10.0 to plot the geologic map on a grey topographic base, and containing a Correlation of Map Units (CMU), a Description of Map Units (DMU), and an index map. 4. Portable Document Format (.pdf) files of: a. the Readme file; includes in Appendix I, data contained in fon_met.txt b. The same graphics as plotted in 2 and 3 above.Test plots have not produced precise 1:24,000-scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following

  15. The PDF4LHC report on PDFs and LHC data: Results from Run I and preparation for Run II

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rojo, Juan; Accardi, Alberto; Ball, Richard D.

    2015-09-16

    The accurate determination of Parton Distribution Functions (PDFs) of the proton is an essential ingredient of the Large Hadron Collider (LHC) program. PDF uncertainties impact a wide range of processes, from Higgs boson characterization and precision Standard Model measurements to New Physics searches. A major recent development in modern PDF analyses has been to exploit the wealth of new information contained in precision measurements from the LHC Run I, as well as progress in tools and methods to include these data in PDF fits. In this report we summarize the information that PDF-sensitive measurements at the LHC have provided somore » far, and review the prospects for further constraining PDFs with data from the recently started Run II. As a result, this document aims to provide useful input to the LHC collaborations to prioritize their PDF-sensitive measurements at Run II, as well as a comprehensive reference for the PDF-fitting collaborations.« less

  16. Assessment of PDF Micromixing Models Using DNS Data for a Two-Step Reaction

    NASA Astrophysics Data System (ADS)

    Tsai, Kuochen; Chakrabarti, Mitali; Fox, Rodney O.; Hill, James C.

    1996-11-01

    Although the probability density function (PDF) method is known to treat the chemical reaction terms exactly, its application to turbulent reacting flows have been overshadowed by the ability to model the molecular mixing terms satisfactorily. In this study, two PDF molecular mixing models, the linear-mean-square-estimation (LMSE or IEM) model and the generalized interaction-by-exchange-with-the-mean (GIEM) model, are compared with the DNS data in decaying turbulence with a two-step parallel-consecutive reaction and two segregated initial conditions: ``slabs" and ``blobs". Since the molecular mixing model is expected to have a strong effect on the mean values of chemical species under such initial conditions, the model evaluation is intended to answer the following questions: Can the PDF models predict the mean values of chemical species correctly with completely segregated initial conditions? (2) Is a single molecular mixing timescale sufficient for the PDF models to predict the mean values with different initial conditions? (3) Will the chemical reactions change the molecular mixing timescales of the reacting species enough to affect the accuracy of the model's prediction for the mean values of chemical species?

  17. PDF modeling of turbulent flows on unstructured grids

    NASA Astrophysics Data System (ADS)

    Bakosi, Jozsef

    In probability density function (PDF) methods of turbulent flows, the joint PDF of several flow variables is computed by numerically integrating a system of stochastic differential equations for Lagrangian particles. Because the technique solves a transport equation for the PDF of the velocity and scalars, a mathematically exact treatment of advection, viscous effects and arbitrarily complex chemical reactions is possible; these processes are treated without closure assumptions. A set of algorithms is proposed to provide an efficient solution of the PDF transport equation modeling the joint PDF of turbulent velocity, frequency and concentration of a passive scalar in geometrically complex configurations. An unstructured Eulerian grid is employed to extract Eulerian statistics, to solve for quantities represented at fixed locations of the domain and to track particles. All three aspects regarding the grid make use of the finite element method. Compared to hybrid methods, the current methodology is stand-alone, therefore it is consistent both numerically and at the level of turbulence closure without the use of consistency conditions. Since both the turbulent velocity and scalar concentration fields are represented in a stochastic way, the method allows for a direct and close interaction between these fields, which is beneficial in computing accurate scalar statistics. Boundary conditions implemented along solid bodies are of the free-slip and no-slip type without the need for ghost elements. Boundary layers at no-slip boundaries are either fully resolved down to the viscous sublayer, explicitly modeling the high anisotropy and inhomogeneity of the low-Reynolds-number wall region without damping or wall-functions or specified via logarithmic wall-functions. As in moment closures and large eddy simulation, these wall-treatments provide the usual trade-off between resolution and computational cost as required by the given application. Particular attention is focused on

  18. A study of hydrogen diffusion flames using PDF turbulence model

    NASA Technical Reports Server (NTRS)

    Hsu, Andrew T.

    1991-01-01

    The application of probability density function (pdf) turbulence models is addressed. For the purpose of accurate prediction of turbulent combustion, an algorithm that combines a conventional computational fluid dynamic (CFD) flow solver with the Monte Carlo simulation of the pdf evolution equation was developed. The algorithm was validated using experimental data for a heated turbulent plane jet. The study of H2-F2 diffusion flames was carried out using this algorithm. Numerical results compared favorably with experimental data. The computations show that the flame center shifts as the equivalence ratio changes, and that for the same equivalence ratio, similarity solutions for flames exist.

  19. A study of hydrogen diffusion flames using PDF turbulence model

    NASA Technical Reports Server (NTRS)

    Hsu, Andrew T.

    1991-01-01

    The application of probability density function (pdf) turbulence models is addressed in this work. For the purpose of accurate prediction of turbulent combustion, an algorithm that combines a conventional CFD flow solver with the Monte Carlo simulation of the pdf evolution equation has been developed. The algorithm has been validated using experimental data for a heated turbulent plane jet. The study of H2-F2 diffusion flames has been carried out using this algorithm. Numerical results compared favorably with experimental data. The computuations show that the flame center shifts as the equivalence ratio changes, and that for the same equivalence ratio, similarity solutions for flames exist.

  20. Publications - PDF 88-8 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 88-8 Publication Details Title: Alaska's mineral industry 1987: Executive summary Authors , Alaska's mineral industry 1987: Executive summary: Alaska Division of Geological & Geophysical Surveys

  1. Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.

    PubMed

    Flavell, Steven W; Pokala, Navin; Macosko, Evan Z; Albrecht, Dirk R; Larsch, Johannes; Bargmann, Cornelia I

    2013-08-29

    Foraging animals have distinct exploration and exploitation behaviors that are organized into discrete behavioral states. Here, we characterize a neuromodulatory circuit that generates long-lasting roaming and dwelling states in Caenorhabditis elegans. We find that two opposing neuromodulators, serotonin and the neuropeptide pigment dispersing factor (PDF), each initiate and extend one behavioral state. Serotonin promotes dwelling states through the MOD-1 serotonin-gated chloride channel. The spontaneous activity of serotonergic neurons correlates with dwelling behavior, and optogenetic modulation of the critical MOD-1-expressing targets induces prolonged dwelling states. PDF promotes roaming states through a Gαs-coupled PDF receptor; optogenetic activation of cAMP production in PDF receptor-expressing cells induces prolonged roaming states. The neurons that produce and respond to each neuromodulator form a distributed circuit orthogonal to the classical wiring diagram, with several essential neurons that express each molecule. The slow temporal dynamics of this neuromodulatory circuit supplement fast motor circuits to organize long-lasting behavioral states. Copyright © 2013 Elsevier Inc. All rights reserved.

  2. Geologic map and digital database of the Romoland 7.5' quadrangle, Riverside County, California

    USGS Publications Warehouse

    Morton, Douglas M.; Digital preparation by Bovard, Kelly R.; Morton, Gregory

    2003-01-01

    Portable Document Format (.pdf) files of: This Readme; includes in Appendix I, data contained in rom_met.txt The same graphic as plotted in 2 above. Test plots have not produced precise 1:24,000- scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formationname, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Even though this is an Open-File Report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above). This Readme file describes the digital data, such as types and general contents of files making up the database, and includes information on how to extract and plot the map and accompanying graphic file. Metadata information can be accessed at http://geo-nsdi.er.usgs.gov/metadata/open-file/03-102 and is included in Appendix I of this Readme.

  3. 77 FR 71831 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-04

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on November 8, 2012, pursuant to.... (``the Act''), 3D Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with the... remains open, and 3D PDF intends to file additional written notifications disclosing all changes in...

  4. 77 FR 56861 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3d PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Production Act of 1993--3d PDF Consortium, Inc. Notice is hereby given that, on August 20, 2012, pursuant to.... (``the Act''), 3D Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with the... remains open, and 3D PDF intends to file additional written notifications disclosing all changes in...

  5. Enriching a document collection by integrating information extraction and PDF annotation

    NASA Astrophysics Data System (ADS)

    Powley, Brett; Dale, Robert; Anisimoff, Ilya

    2009-01-01

    Modern digital libraries offer all the hyperlinking possibilities of the World Wide Web: when a reader finds a citation of interest, in many cases she can now click on a link to be taken to the cited work. This paper presents work aimed at providing the same ease of navigation for legacy PDF document collections that were created before the possibility of integrating hyperlinks into documents was ever considered. To achieve our goal, we need to carry out two tasks: first, we need to identify and link citations and references in the text with high reliability; and second, we need the ability to determine physical PDF page locations for these elements. We demonstrate the use of a high-accuracy citation extraction algorithm which significantly improves on earlier reported techniques, and a technique for integrating PDF processing with a conventional text-stream based information extraction pipeline. We demonstrate these techniques in the context of a particular document collection, this being the ACL Anthology; but the same approach can be applied to other document sets.

  6. Publications - PDF 89-7 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 89-7 Publication Details Title: Summary of Alaska's mineral industry in 1988 Authors , Summary of Alaska's mineral industry in 1988: Alaska Division of Geological & Geophysical Surveys

  7. Publications - PDF 90-10 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 90-10 Publication Details Title: Summary of Alaska's mineral industry in 1989 Authors , Summary of Alaska's mineral industry in 1989: Alaska Division of Geological & Geophysical Surveys

  8. Implementation of Super-Encryption with Trithemius Algorithm and Double Transposition Cipher in Securing PDF Files on Android Platform

    NASA Astrophysics Data System (ADS)

    Budiman, M. A.; Rachmawati, D.; Jessica

    2018-03-01

    This study aims to combine the trithemus algorithm and double transposition cipher in file security that will be implemented to be an Android-based application. The parameters being examined are the real running time, and the complexity value. The type of file to be used is a file in PDF format. The overall result shows that the complexity of the two algorithms with duper encryption method is reported as Θ (n 2). However, the processing time required in the encryption process uses the Trithemius algorithm much faster than using the Double Transposition Cipher. With the length of plaintext and password linearly proportional to the processing time.

  9. 77 FR 23754 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-3D PDF Consortium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... Production Act of 1993--3D PDF Consortium, Inc. Notice is hereby given that, on March 27, 2012, pursuant to.... (``the Act''), 3D PDF Consortium, Inc. (``3D PDF'') has filed written notifications simultaneously with... Corporation, Boulder, CO; Aras Corporation, Andover, MA; Tetra 4D, LLC, Seattle, WA; Tech Soft 3D, Berkeley...

  10. Modeling error PDF optimization based wavelet neural network modeling of dynamic system and its application in blast furnace ironmaking

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhou, Ping; Wang, Chenyu; Li, Mingjie

    In general, the modeling errors of dynamic system model are a set of random variables. The traditional performance index of modeling such as means square error (MSE) and root means square error (RMSE) can not fully express the connotation of modeling errors with stochastic characteristics both in the dimension of time domain and space domain. Therefore, the probability density function (PDF) is introduced to completely describe the modeling errors in both time scales and space scales. Based on it, a novel wavelet neural network (WNN) modeling method is proposed by minimizing the two-dimensional (2D) PDF shaping of modeling errors. First,more » the modeling error PDF by the tradional WNN is estimated using data-driven kernel density estimation (KDE) technique. Then, the quadratic sum of 2D deviation between the modeling error PDF and the target PDF is utilized as performance index to optimize the WNN model parameters by gradient descent method. Since the WNN has strong nonlinear approximation and adaptive capability, and all the parameters are well optimized by the proposed method, the developed WNN model can make the modeling error PDF track the target PDF, eventually. Simulation example and application in a blast furnace ironmaking process show that the proposed method has a higher modeling precision and better generalization ability compared with the conventional WNN modeling based on MSE criteria. Furthermore, the proposed method has more desirable estimation for modeling error PDF that approximates to a Gaussian distribution whose shape is high and narrow.« less

  11. Modeling error PDF optimization based wavelet neural network modeling of dynamic system and its application in blast furnace ironmaking

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhou, Ping; Wang, Chenyu; Li, Mingjie

    In general, the modeling errors of dynamic system model are a set of random variables. The traditional performance index of modeling such as means square error (MSE) and root means square error (RMSE) cannot fully express the connotation of modeling errors with stochastic characteristics both in the dimension of time domain and space domain. Therefore, the probability density function (PDF) is introduced to completely describe the modeling errors in both time scales and space scales. Based on it, a novel wavelet neural network (WNN) modeling method is proposed by minimizing the two-dimensional (2D) PDF shaping of modeling errors. First, themore » modeling error PDF by the traditional WNN is estimated using data-driven kernel density estimation (KDE) technique. Then, the quadratic sum of 2D deviation between the modeling error PDF and the target PDF is utilized as performance index to optimize the WNN model parameters by gradient descent method. Since the WNN has strong nonlinear approximation and adaptive capability, and all the parameters are well optimized by the proposed method, the developed WNN model can make the modeling error PDF track the target PDF, eventually. Simulation example and application in a blast furnace ironmaking process show that the proposed method has a higher modeling precision and better generalization ability compared with the conventional WNN modeling based on MSE criteria. However, the proposed method has more desirable estimation for modeling error PDF that approximates to a Gaussian distribution whose shape is high and narrow.« less

  12. Modeling error PDF optimization based wavelet neural network modeling of dynamic system and its application in blast furnace ironmaking

    DOE PAGES

    Zhou, Ping; Wang, Chenyu; Li, Mingjie; ...

    2018-01-31

    In general, the modeling errors of dynamic system model are a set of random variables. The traditional performance index of modeling such as means square error (MSE) and root means square error (RMSE) cannot fully express the connotation of modeling errors with stochastic characteristics both in the dimension of time domain and space domain. Therefore, the probability density function (PDF) is introduced to completely describe the modeling errors in both time scales and space scales. Based on it, a novel wavelet neural network (WNN) modeling method is proposed by minimizing the two-dimensional (2D) PDF shaping of modeling errors. First, themore » modeling error PDF by the traditional WNN is estimated using data-driven kernel density estimation (KDE) technique. Then, the quadratic sum of 2D deviation between the modeling error PDF and the target PDF is utilized as performance index to optimize the WNN model parameters by gradient descent method. Since the WNN has strong nonlinear approximation and adaptive capability, and all the parameters are well optimized by the proposed method, the developed WNN model can make the modeling error PDF track the target PDF, eventually. Simulation example and application in a blast furnace ironmaking process show that the proposed method has a higher modeling precision and better generalization ability compared with the conventional WNN modeling based on MSE criteria. However, the proposed method has more desirable estimation for modeling error PDF that approximates to a Gaussian distribution whose shape is high and narrow.« less

  13. Hybrid finite-volume/transported PDF method for the simulation of turbulent reactive flows

    NASA Astrophysics Data System (ADS)

    Raman, Venkatramanan

    A novel computational scheme is formulated for simulating turbulent reactive flows in complex geometries with detailed chemical kinetics. A Probability Density Function (PDF) based method that handles the scalar transport equation is coupled with an existing Finite Volume (FV) Reynolds-Averaged Navier-Stokes (RANS) flow solver. The PDF formulation leads to closed chemical source terms and facilitates the use of detailed chemical mechanisms without approximations. The particle-based PDF scheme is modified to handle complex geometries and grid structures. Grid-independent particle evolution schemes that scale linearly with the problem size are implemented in the Monte-Carlo PDF solver. A novel algorithm, in situ adaptive tabulation (ISAT) is employed to ensure tractability of complex chemistry involving a multitude of species. Several non-reacting test cases are performed to ascertain the efficiency and accuracy of the method. Simulation results from a turbulent jet-diffusion flame case are compared against experimental data. The effect of micromixing model, turbulence model and reaction scheme on flame predictions are discussed extensively. Finally, the method is used to analyze the Dow Chlorination Reactor. Detailed kinetics involving 37 species and 158 reactions as well as a reduced form with 16 species and 21 reactions are used. The effect of inlet configuration on reactor behavior and product distribution is analyzed. Plant-scale reactors exhibit quenching phenomena that cannot be reproduced by conventional simulation methods. The FV-PDF method predicts quenching accurately and provides insight into the dynamics of the reactor near extinction. The accuracy of the fractional time-stepping technique in discussed in the context of apparent multiple-steady states observed in a non-premixed feed configuration of the chlorination reactor.

  14. The orbital PDF: general inference of the gravitational potential from steady-state tracers

    NASA Astrophysics Data System (ADS)

    Han, Jiaxin; Wang, Wenting; Cole, Shaun; Frenk, Carlos S.

    2016-02-01

    We develop two general methods to infer the gravitational potential of a system using steady-state tracers, I.e. tracers with a time-independent phase-space distribution. Combined with the phase-space continuity equation, the time independence implies a universal orbital probability density function (oPDF) dP(λ|orbit) ∝ dt, where λ is the coordinate of the particle along the orbit. The oPDF is equivalent to Jeans theorem, and is the key physical ingredient behind most dynamical modelling of steady-state tracers. In the case of a spherical potential, we develop a likelihood estimator that fits analytical potentials to the system and a non-parametric method (`phase-mark') that reconstructs the potential profile, both assuming only the oPDF. The methods involve no extra assumptions about the tracer distribution function and can be applied to tracers with any arbitrary distribution of orbits, with possible extension to non-spherical potentials. The methods are tested on Monte Carlo samples of steady-state tracers in dark matter haloes to show that they are unbiased as well as efficient. A fully documented C/PYTHON code implementing our method is freely available at a GitHub repository linked from http://icc.dur.ac.uk/data/#oPDF.

  15. Modeling of turbulent supersonic H2-air combustion with an improved joint beta PDF

    NASA Technical Reports Server (NTRS)

    Baurle, R. A.; Hassan, H. A.

    1991-01-01

    Attempts at modeling recent experiments of Cheng et al. indicated that discrepancies between theory and experiment can be a result of the form of assumed probability density function (PDF) and/or the turbulence model employed. Improvements in both the form of the assumed PDF and the turbulence model are presented. The results are again used to compare with measurements. Initial comparisons are encouraging.

  16. Research on Optimization of Encoding Algorithm of PDF417 Barcodes

    NASA Astrophysics Data System (ADS)

    Sun, Ming; Fu, Longsheng; Han, Shuqing

    The purpose of this research is to develop software to optimize the data compression of a PDF417 barcode using VC++6.0. According to the different compression mode and the particularities of Chinese, the relevant approaches which optimize the encoding algorithm of data compression such as spillage and the Chinese characters encoding are proposed, a simple approach to compute complex polynomial is introduced. After the whole data compression is finished, the number of the codeword is reduced and then the encoding algorithm is optimized. The developed encoding system of PDF 417 barcodes will be applied in the logistics management of fruits, therefore also will promote the fast development of the two-dimensional bar codes.

  17. Publications - PDF 87-2 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 87-2 Publication Details Title: Alaska's mineral industry 1986: Executive summary Authors : Executive summary: Alaska Division of Geological & Geophysical Surveys Public Data File 87-2, 5 p. http

  18. Ionization compression impact on dense gas distribution and star formation. Probability density functions around H II regions as seen by Herschel

    NASA Astrophysics Data System (ADS)

    Tremblin, P.; Schneider, N.; Minier, V.; Didelon, P.; Hill, T.; Anderson, L. D.; Motte, F.; Zavagno, A.; André, Ph.; Arzoumanian, D.; Audit, E.; Benedettini, M.; Bontemps, S.; Csengeri, T.; Di Francesco, J.; Giannini, T.; Hennemann, M.; Nguyen Luong, Q.; Marston, A. P.; Peretto, N.; Rivera-Ingraham, A.; Russeil, D.; Rygl, K. L. J.; Spinoglio, L.; White, G. J.

    2014-04-01

    Aims: Ionization feedback should impact the probability distribution function (PDF) of the column density of cold dust around the ionized gas. We aim to quantify this effect and discuss its potential link to the core and initial mass function (CMF/IMF). Methods: We used Herschel column density maps of several regions observed within the HOBYS key program in a systematic way: M 16, the Rosette and Vela C molecular clouds, and the RCW 120 H ii region. We computed the PDFs in concentric disks around the main ionizing sources, determined their properties, and discuss the effect of ionization pressure on the distribution of the column density. Results: We fitted the column density PDFs of all clouds with two lognormal distributions, since they present a "double-peak" or an enlarged shape in the PDF. Our interpretation is that the lowest part of the column density distribution describes the turbulent molecular gas, while the second peak corresponds to a compression zone induced by the expansion of the ionized gas into the turbulent molecular cloud. Such a double peak is not visible for all clouds associated with ionization fronts, but it depends on the relative importance of ionization pressure and turbulent ram pressure. A power-law tail is present for higher column densities, which are generally ascribed to the effect of gravity. The condensations at the edge of the ionized gas have a steep compressed radial profile, sometimes recognizable in the flattening of the power-law tail. This could lead to an unambiguous criterion that is able to disentangle triggered star formation from pre-existing star formation. Conclusions: In the context of the gravo-turbulent scenario for the origin of the CMF/IMF, the double-peaked or enlarged shape of the PDF may affect the formation of objects at both the low-mass and the high-mass ends of the CMF/IMF. In particular, a broader PDF is required by the gravo-turbulent scenario to fit the IMF properly with a reasonable initial Mach

  19. Blocking synaptic transmission with tetanus toxin light chain reveals modes of neurotransmission in the PDF-positive circadian clock neurons of Drosophila melanogaster.

    PubMed

    Umezaki, Yujiro; Yasuyama, Kouji; Nakagoshi, Hideki; Tomioka, Kenji

    2011-09-01

    Circadian locomotor rhythms of Drosophila melanogaster are controlled by a neuronal circuit composed of approximately 150 clock neurons that are roughly classified into seven groups. In the circuit, a group of neurons expressing pigment-dispersing factor (PDF) play an important role in organizing the pacemaking system. Recent studies imply that unknown chemical neurotransmitter(s) (UNT) other than PDF is also expressed in the PDF-positive neurons. To explore its role in the circadian pacemaker, we examined the circadian locomotor rhythms of pdf-Gal4/UAS-TNT transgenic flies in which chemical synaptic transmission in PDF-positive neurons was blocked by expressed tetanus toxin light chain (TNT). In constant darkness (DD), the flies showed a free-running rhythm, which was similar to that of wild-type flies but significantly different from pdf null mutants. Under constant light conditions (LL), however, they often showed complex rhythms with a short period and a long period component. The UNT is thus likely involved in the synaptic transmission in the clock network and its release caused by LL leads to arrhythmicity. Immunocytochemistry revealed that LL induced phase separation in TIMELESS (TIM) cycling among some of the PDF-positive and PDF-negative clock neurons in the transgenic flies. These results suggest that both PDF and UNT play important roles in the Drosophila circadian clock, and activation of PDF pathway alone by LL leads to the complex locomotor rhythm through desynchronized oscillation among some of the clock neurons. Copyright © 2011 Elsevier Ltd. All rights reserved.

  20. PDF turbulence modeling and DNS

    NASA Technical Reports Server (NTRS)

    Hsu, A. T.

    1992-01-01

    The problem of time discontinuity (or jump condition) in the coalescence/dispersion (C/D) mixing model is addressed in probability density function (pdf). A C/D mixing model continuous in time is introduced. With the continuous mixing model, the process of chemical reaction can be fully coupled with mixing. In the case of homogeneous turbulence decay, the new model predicts a pdf very close to a Gaussian distribution, with finite higher moments also close to that of a Gaussian distribution. Results from the continuous mixing model are compared with both experimental data and numerical results from conventional C/D models. The effect of Coriolis forces on compressible homogeneous turbulence is studied using direct numerical simulation (DNS). The numerical method used in this study is an eight order compact difference scheme. Contrary to the conclusions reached by previous DNS studies on incompressible isotropic turbulence, the present results show that the Coriolis force increases the dissipation rate of turbulent kinetic energy, and that anisotropy develops as the Coriolis force increases. The Taylor-Proudman theory does apply since the derivatives in the direction of the rotation axis vanishes rapidly. A closer analysis reveals that the dissipation rate of the incompressible component of the turbulent kinetic energy indeed decreases with a higher rotation rate, consistent with incompressible flow simulations (Bardina), while the dissipation rate of the compressible part increases; the net gain is positive. Inertial waves are observed in the simulation results.

  1. Nuclear PDF for neutrino and charged lepton data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kovarik, K.

    2011-10-06

    Neutrino Deep Inelastic Scattering (DIS) on nuclei is an essential process to constrain the strange quark parton distribution functions (PDF) in the proton. The critical component on the way to using the neutrino DIS data in a proton PDF analysis is understanding the nuclear effects in parton distribution functions. We parametrize these effects by nuclear parton distribution functions (NPDF). Here we compare results from two analysis of NPDF both done at next-to-leading order in QCD. The first uses neutral current charged-lepton (l{sup {+-}A}) Deeply Inelastic Scattering (DIS) and Drell-Yan data for several nuclear targets and the second uses neutrino-nucleon DISmore » data. We compare the nuclear corrections factors (F{sub 2}{sup Fe}/F{sub 2}{sup D}) for the charged-lepton data with other results from the literature. In particular, we compare and contrast fits based upon the charged-lepton DIS data with those using neutrino-nucleon DIS data.« less

  2. Preliminary geologic map of the Elsinore 7.5' Quadrangle, Riverside County, California

    USGS Publications Warehouse

    Morton, Douglas M.; Weber, F. Harold; Digital preparation: Alvarez, Rachel M.; Burns, Diane

    2003-01-01

    Open-File Report 03-281 contains a digital geologic map database of the Elsinore 7.5’ quadrangle, Riverside County, California that includes: 1. ARC/INFO (Environmental Systems Research Institute, http://www.esri.com) version 7.2.1 coverages of the various elements of the geologic map. 2. A Postscript file to plot the geologic map on a topographic base, and containing a Correlation of Map Units diagram (CMU), a Description of Map Units (DMU), and an index map. 3. Portable Document Format (.pdf) files of: a. This Readme; includes in Appendix I, data contained in els_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced precise 1:24,000-scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Even though this is an Open-File Report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above).

  3. A Comparative Study of PDF Generation Methods: Measuring Loss of Fidelity When Converting Arabic and Persian MS Word Files to PDF

    DTIC Science & Technology

    2011-02-17

    document objects, on one or more electronic document pages. These commands have their roots in typography , so, to understand the PDF Language, one...must have at least a rudimentary understanding of typography . Only a few of the typographic commands, called text showing operators, can hold strings

  4. Publications - PDF 91-6 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 91-6 Publication Details Title: Summary of Alaska's mineral industry for 1990 Authors ., Bundtzen, T.K., and Wood, J.E., 1991, Summary of Alaska's mineral industry for 1990: Alaska Division of

  5. Publications - PDF 98-39 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 98-39 Publication Details Title: Rock geochemistry from the Manley mining district ., Bundtzen, T.K., Newberry, R.J., Dover, J.H., and Blodgett, R.B., 1998, Rock geochemistry from the Manley

  6. STP 4-06 Model-Based Technical Data in Procurement, 3D PDF Technology Data Demonstration Project. Phase 1 Summary

    DTIC Science & Technology

    2015-07-01

    O R G STP 4-06 MODEL-BASED TECHNICAL DATA IN PROCUREMENT 3D PDF TECHNOLOGY DATA DEMONSTRATION PROJECT PHASE 1 SUMMARY REPORT DL309T2...LMI’s ISO- certified quality management procedures. J U L Y 2 0 1 5 STP 4-06 MODEL-BASED TECHNICAL DATA IN PROCUREMENT 3D PDF TECHNICAL DATA...Based Technical Data ..................................................................................... 5 3D PDF Demonstration Team

  7. Soda Lake Well Lithology Data and Geologic Cross-Sections

    DOE Data Explorer

    Faulds, James E.

    2013-12-31

    Comprehensive catalogue of drill‐hole data in spreadsheet, shapefile, and Geosoft database formats. Includes XYZ locations of well heads, year drilled, type of well, operator, total depths, well path data (deviations), lithology logs, and temperature data. Plus, 13 cross‐sections in Adobe Illustrator format.

  8. Synaptic connections of PDF-immunoreactive lateral neurons projecting to the dorsal protocerebrum of Drosophila melanogaster.

    PubMed

    Yasuyama, Kouji; Meinertzhagen, Ian A

    2010-02-01

    Recent studies in Drosophila melanogaster indicate that the neuropeptide pigment-dispersing factor (PDF) is an important output signal from a set of major clock neurons, s-LN(v)s (small ventral lateral neurons), which transmit the circadian phase to subsets of other clock neurons, DNs (dorsal neurons). Both s-LN(v)s and DNs have fiber projections to the dorsal protocerebrum of the brain, so that this area is a conspicuous locus for coupling between different subsets of clock neurons. To unravel the neural circuits underlying the fly's circadian rhythms, we examined the detailed subcellular morphology of the PDF-positive fibers of the s-LN(v)s in the dorsal protocerebrum, focusing on their synaptic connections, using preembedding immunoelectron microscopy. To examine the distribution of synapses, we also reconstructed the three-dimensional morphology of PDF-positive varicosities from fiber profiles in the dorsal protocerebrum. The varicosities contained large dense-core vesicles (DCVs), and also numerous small clear vesicles, forming divergent output synapses onto unlabeled neurites. The DCVs apparently dock at nonsynaptic sites, suggesting their nonsynaptic release. In addition, a 3D reconstruction revealed the presence of input synapses onto the PDF-positive fibers. These were detected less frequently than output sites. These observations suggest that the PDF-positive clock neurons receive neural inputs directly through synaptic connections in the dorsal protocerebrum, in addition to supplying dual outputs, either synaptic or via paracrine release of the DCV contents, to unidentified target neurons.

  9. On Variations in the Level of PER in Glial Clocks of Drosophila Optic Lobe and Its Negative Regulation by PDF Signaling.

    PubMed

    Górska-Andrzejak, Jolanta; Chwastek, Elżbieta M; Walkowicz, Lucyna; Witek, Kacper

    2018-01-01

    We show that the level of the core protein of the circadian clock Period (PER) expressed by glial peripheral oscillators depends on their location in the Drosophila optic lobe. It appears to be controlled by the ventral lateral neurons (LNvs) that release the circadian neurotransmitter Pigment Dispersing Factor (PDF). We demonstrate that glial cells of the distal medulla neuropil (dMnGl) that lie in the vicinity of the PDF-releasing terminals of the LNvs possess receptors for PDF (PDFRs) and express PER at significantly higher level than other types of glia. Surprisingly, the amplitude of PER molecular oscillations in dMnGl is increased twofold in PDF-free environment, that is in Pdf 0 mutants. The Pdf 0 mutants also reveal an increased level of glia-specific protein REPO in dMnGl. The photoreceptors of the compound eye (R-cells) of the PDF-null flies, on the other hand, exhibit de-synchrony of PER molecular oscillations, which manifests itself as increased variability of PER-specific immunofluorescence among the R-cells. Moreover, the daily pattern of expression of the presynaptic protein Bruchpilot (BRP) in the lamina terminals of the R-cells is changed in Pdf 0 mutant. Considering that PDFRs are also expressed by the marginal glia of the lamina that surround the R-cell terminals, the LNv pacemakers appear to be the likely modulators of molecular cycling in the peripheral clocks of both the glial cells and the photoreceptors of the compound eye. Consequently, some form of PDF-based coupling of the glial clocks and the photoreceptors of the eye with the central LNv pacemakers must be operational.

  10. On Variations in the Level of PER in Glial Clocks of Drosophila Optic Lobe and Its Negative Regulation by PDF Signaling

    PubMed Central

    Górska-Andrzejak, Jolanta; Chwastek, Elżbieta M.; Walkowicz, Lucyna; Witek, Kacper

    2018-01-01

    We show that the level of the core protein of the circadian clock Period (PER) expressed by glial peripheral oscillators depends on their location in the Drosophila optic lobe. It appears to be controlled by the ventral lateral neurons (LNvs) that release the circadian neurotransmitter Pigment Dispersing Factor (PDF). We demonstrate that glial cells of the distal medulla neuropil (dMnGl) that lie in the vicinity of the PDF-releasing terminals of the LNvs possess receptors for PDF (PDFRs) and express PER at significantly higher level than other types of glia. Surprisingly, the amplitude of PER molecular oscillations in dMnGl is increased twofold in PDF-free environment, that is in Pdf0 mutants. The Pdf0 mutants also reveal an increased level of glia-specific protein REPO in dMnGl. The photoreceptors of the compound eye (R-cells) of the PDF-null flies, on the other hand, exhibit de-synchrony of PER molecular oscillations, which manifests itself as increased variability of PER-specific immunofluorescence among the R-cells. Moreover, the daily pattern of expression of the presynaptic protein Bruchpilot (BRP) in the lamina terminals of the R-cells is changed in Pdf0 mutant. Considering that PDFRs are also expressed by the marginal glia of the lamina that surround the R-cell terminals, the LNv pacemakers appear to be the likely modulators of molecular cycling in the peripheral clocks of both the glial cells and the photoreceptors of the compound eye. Consequently, some form of PDF-based coupling of the glial clocks and the photoreceptors of the eye with the central LNv pacemakers must be operational. PMID:29615925

  11. Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: immunocytochemical evidence from specific monoclonal antibodies.

    PubMed

    Honda, Takeshi; Matsushima, Ayami; Sumida, Kazunori; Chuman, Yoshiro; Sakaguchi, Kazuyasu; Onoue, Hitoshi; Meinertzhagen, Ian A; Shimohigashi, Yasuyuki; Shimohigashi, Miki

    2006-11-20

    Pigment-dispersing factor (PDF) is an 18-mer peptide that acts as a principal neurotransmitter of the insect circadian clock. Our previous study, utilizing anti-Uca beta-PDH polyclonal antibody (pAb) to immunolabel the optic lobe of the cricket Gryllus bimaculatus, suggested the existence of an alternative PDF-like peptide in the outer cells of the first neuropile, or lamina (La), which were much less immunoreactive than the inner cells of the second neuropile, the medulla (Me). To obtain structural information about such a PDF-like peptide, we prepared 10 anti-Gryllus PDF monoclonal (mAb) and pAb antibodies and analyzed their detailed epitope specificities. The PDFMe and PDFLa inner cells and their axonal projections were clearly immunoreactive to all these antibodies, revealing the widespread immunocytochemical organization of the PDF system in the optic lobe, as seen previously with anti-Uca beta-PDH pAb and anti-Gryllus PDF mAb, the epitope structures of which were also clarified in this study. The lamina outer cells, which we found lacked a target pdf mRNA, displayed specific immunoreactivities, indicating that the cells contain a distinct PDF-like peptide possessing both N- and C-terminal structures. These cells were not immunolabeled by some other monoclonal antibodies, however, implying that the PDFLa outer cells have a PDF isoform peptide devoid of Asn at positions 6 and 16. This isoform was also identified in a varicose arborization in the lamina. These results suggest not only the structure of the peptide, but also the possibility of additional functions of this novel PDF isoform.

  12. Publishing large DNA sequence data in reduced spaces and lasting formats, in paper or PDF.

    PubMed

    Aguiar, Alexandre Pires

    2013-02-04

    Scientific publications carry a practical moral duty: they must last. Along that line of thinking, some methods are proposed to allow economically and structurally viable publication of DNA sequence data of any size in printed matter and PDFs. The proposal is primarily aimed at contributing for preserving information for the future, while allowing authors to avoid information splitting and complement storage ex situ, that is, in server machines, outside the publication proper. The technique may also help to solve the impasse between the ICZN Code requirement that a new nomen be associated to diagnostic characters for the taxon vs. the phylogenetic definition of taxa, based on cladograms only: sequence data are characters, and can now be easily and comfortably included in taxonomic publications, with direct textual mention to their diagnostic sections. The compression level achieved allows the inclusion of all wanted DNA or RNA sequences in the same printed matter or PDF publications where the sequences are cited and discussed. Reduced font sizes, invisible fonts, and original 2D black & white and color barcodes are illustrated and briefly discussed. The level of data compression achieved can allow each full page of sequence data, or about 5000 characters, to be precisely coded into a color barcode as small as a square of 1.5 mm. A practical example is provided with Taeniogonalos woodorum Smith (Hymenoptera, Trigonalidae). Free software to generate publishable barcodes from txt or FASTA files is provided at www.systaxon.ufes.br/dna.

  13. A new subgrid-scale representation of hydrometeor fields using a multivariate PDF

    DOE PAGES

    Griffin, Brian M.; Larson, Vincent E.

    2016-06-03

    The subgrid-scale representation of hydrometeor fields is important for calculating microphysical process rates. In order to represent subgrid-scale variability, the Cloud Layers Unified By Binormals (CLUBB) parameterization uses a multivariate probability density function (PDF). In addition to vertical velocity, temperature, and moisture fields, the PDF includes hydrometeor fields. Previously, hydrometeor fields were assumed to follow a multivariate single lognormal distribution. Now, in order to better represent the distribution of hydrometeors, two new multivariate PDFs are formulated and introduced.The new PDFs represent hydrometeors using either a delta-lognormal or a delta-double-lognormal shape. The two new PDF distributions, plus the previous single lognormalmore » shape, are compared to histograms of data taken from large-eddy simulations (LESs) of a precipitating cumulus case, a drizzling stratocumulus case, and a deep convective case. In conclusion, the warm microphysical process rates produced by the different hydrometeor PDFs are compared to the same process rates produced by the LES.« less

  14. Comparison of PDF and Moment Closure Methods in the Modeling of Turbulent Reacting Flows

    NASA Technical Reports Server (NTRS)

    Norris, Andrew T.; Hsu, Andrew T.

    1994-01-01

    In modeling turbulent reactive flows, Probability Density Function (PDF) methods have an advantage over the more traditional moment closure schemes in that the PDF formulation treats the chemical reaction source terms exactly, while moment closure methods are required to model the mean reaction rate. The common model used is the laminar chemistry approximation, where the effects of turbulence on the reaction are assumed negligible. For flows with low turbulence levels and fast chemistry, the difference between the two methods can be expected to be small. However for flows with finite rate chemistry and high turbulence levels, significant errors can be expected in the moment closure method. In this paper, the ability of the PDF method and the moment closure scheme to accurately model a turbulent reacting flow is tested. To accomplish this, both schemes were used to model a CO/H2/N2- air piloted diffusion flame near extinction. Identical thermochemistry, turbulence models, initial conditions and boundary conditions are employed to ensure a consistent comparison can be made. The results of the two methods are compared to experimental data as well as to each other. The comparison reveals that the PDF method provides good agreement with the experimental data, while the moment closure scheme incorrectly shows a broad, laminar-like flame structure.

  15. Disks and Outflows Around Young Stars

    NASA Astrophysics Data System (ADS)

    Beckwith, Steven; Staude, Jakob; Quetz, Axel; Natta, Antonella

    The subject of the book, the ubiquitous circumstellar disks around very young stars and the corresponding jets of outflowing matter, has recently become one of the hottest areas in astrophysics. The disks are thought to be precursors to planetary systems, and the outflows are thought to be a necessary phase in the formation of a young star, helping the star to get rid of angular momentum and energy as it makes its way onto the main sequence. The possible connections to planetary systems and stellar astrophysics makes these topics especially broad, appealing to generalists and specialists alike. The CD not only contains papers that could not be printed in the book but allows the authors to include a fair amount of data, often displayed as color images. The CD-ROM contains all the contributions printed in the corresponding book (Lecture Notes in Physics Vol. 465) and, in addition, those presented exclusively in digital form. Each contribution consists of a file in portable document format (PDF). The electronic version allows full-text searching within each file using Adobe's Acrobat Reader providing instructions for installation on Unix (Sun), PC and Macintosh computers, respectively. All contributions can be printed out; the color diagrams and color frames, which are printed in black and white in the book, can be viewed in color on screen.

  16. FNV: light-weight flash-based network and pathway viewer.

    PubMed

    Dannenfelser, Ruth; Lachmann, Alexander; Szenk, Mariola; Ma'ayan, Avi

    2011-04-15

    Network diagrams are commonly used to visualize biochemical pathways by displaying the relationships between genes, proteins, mRNAs, microRNAs, metabolites, regulatory DNA elements, diseases, viruses and drugs. While there are several currently available web-based pathway viewers, there is still room for improvement. To this end, we have developed a flash-based network viewer (FNV) for the visualization of small to moderately sized biological networks and pathways. Written in Adobe ActionScript 3.0, the viewer accepts simple Extensible Markup Language (XML) formatted input files to display pathways in vector graphics on any web-page providing flexible layout options, interactivity with the user through tool tips, hyperlinks and the ability to rearrange nodes on the screen. FNV was utilized as a component in several web-based systems, namely Genes2Networks, Lists2Networks, KEA, ChEA and PathwayGenerator. In addition, FVN can be used to embed pathways inside pdf files for the communication of pathways in soft publication materials. FNV is available for use and download along with the supporting documentation and sample networks at http://www.maayanlab.net/FNV. avi.maayan@mssm.edu.

  17. Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila.

    PubMed

    Choi, Charles; Cao, Guan; Tanenhaus, Anne K; McCarthy, Ellena V; Jung, Misun; Schleyer, William; Shang, Yuhua; Rosbash, Michael; Yin, Jerry C P; Nitabach, Michael N

    2012-08-30

    Drosophila melanogaster flies concentrate behavioral activity around dawn and dusk. This organization of daily activity is controlled by central circadian clock neurons, including the lateral-ventral pacemaker neurons (LN(v)s) that secrete the neuropeptide PDF (pigment dispersing factor). Previous studies have demonstrated the requirement for PDF signaling to PDF receptor (PDFR)-expressing dorsal clock neurons in organizing circadian activity. Although LN(v)s also express functional PDFR, the role of these autoreceptors has remained enigmatic. Here, we show that (1) PDFR activation in LN(v)s shifts the balance of circadian activity from evening to morning, similar to behavioral responses to summer-like environmental conditions, and (2) this shift is mediated by stimulation of the Gα,s-cAMP pathway and a consequent change in PDF/neurotransmitter corelease from the LN(v)s. These results suggest another mechanism for environmental control of the allocation of circadian activity and provide new general insight into the role of neuropeptide autoreceptors in behavioral control circuits. Copyright © 2012 The Authors. Published by Elsevier Inc. All rights reserved.

  18. Autoreceptor Modulation of Peptide/Neurotransmitter Co-release from PDF Neurons Determines Allocation of Circadian Activity in Drosophila

    PubMed Central

    Choi, Charles; Cao, Guan; Tanenhaus, Anne K.; McCarthy, Ellena v.; Jung, Misun; Schleyer, William; Shang, Yuhua; Rosbash, Michael; Yin, Jerry C.P.; Nitabach, Michael N.

    2012-01-01

    Drosophila melanogaster flies concentrate behavioral activity around dawn and dusk. This organization of daily activity is controlled by central circadian clock neurons, including the lateral ventral pacemaker neurons (LNvs) that secrete the neuropeptide PDF (Pigment Dispersing Factor). Previous studies have demonstrated the requirement for PDF signaling to PDF receptor (PDFR)-expressing dorsal clock neurons in organizing circadian activity. While LNvs also express functional PDFR, the role of these autoreceptors has remained enigmatic. Here we show that (1) PDFR activation in LNvs shifts the balance of circadian activity from evening to morning, similar to behavioral responses to summer-like environmental conditions and (2) this shift is mediated by stimulation of the Ga,s-cAMP pathway and a consequent change in PDF/neurotransmitter co-release from the LNvs. These results suggest a novel mechanism for environmental control of the allocation of circadian activity and provide new general insight into the role of neuropeptide autoreceptors in behavioral control circuits. PMID:22938867

  19. STAR FORMATION IN TURBULENT MOLECULAR CLOUDS WITH COLLIDING FLOW

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Matsumoto, Tomoaki; Dobashi, Kazuhito; Shimoikura, Tomomi, E-mail: matsu@hosei.ac.jp

    2015-03-10

    Using self-gravitational hydrodynamical numerical simulations, we investigated the evolution of high-density turbulent molecular clouds swept by a colliding flow. The interaction of shock waves due to turbulence produces networks of thin filamentary clouds with a sub-parsec width. The colliding flow accumulates the filamentary clouds into a sheet cloud and promotes active star formation for initially high-density clouds. Clouds with a colliding flow exhibit a finer filamentary network than clouds without a colliding flow. The probability distribution functions (PDFs) for the density and column density can be fitted by lognormal functions for clouds without colliding flow. When the initial turbulence ismore » weak, the column density PDF has a power-law wing at high column densities. The colliding flow considerably deforms the PDF, such that the PDF exhibits a double peak. The stellar mass distributions reproduced here are consistent with the classical initial mass function with a power-law index of –1.35 when the initial clouds have a high density. The distribution of stellar velocities agrees with the gas velocity distribution, which can be fitted by Gaussian functions for clouds without colliding flow. For clouds with colliding flow, the velocity dispersion of gas tends to be larger than the stellar velocity dispersion. The signatures of colliding flows and turbulence appear in channel maps reconstructed from the simulation data. Clouds without colliding flow exhibit a cloud-scale velocity shear due to the turbulence. In contrast, clouds with colliding flow show a prominent anti-correlated distribution of thin filaments between the different velocity channels, suggesting collisions between the filamentary clouds.« less

  20. Constraints on the Profiles of Total Water PDF in AGCMs from AIRS and a High-Resolution Model

    NASA Technical Reports Server (NTRS)

    Molod, Andrea

    2012-01-01

    Atmospheric general circulation model (AGCM) cloud parameterizations generally include an assumption about the subgrid-scale probability distribution function (PDF) of total water and its vertical profile. In the present study, the Atmospheric Infrared Sounder (AIRS) monthly-mean cloud amount and relative humidity fields are used to compute a proxy for the second moment of an AGCM total water PDF called the RH01 diagnostic, which is the AIRS mean relative humidity for cloud fractions of 0.1 or less. The dependence of the second moment on horizontal grid resolution is analyzed using results from a high-resolution global model simulation.The AIRS-derived RH01 diagnostic is generally larger near the surface than aloft, indicating a narrower PDF near the surface, and varies with the type of underlying surface. High-resolution model results show that the vertical structure of profiles of the AGCM PDF second moment is unchanged as the grid resolution changes from 200 to 100 to 50 km, and that the second-moment profiles shift toward higher values with decreasing grid spacing.Several Goddard Earth Observing System, version 5 (GEOS-5), AGCM simulations were performed with several choices for the profile of the PDF second moment. The resulting cloud and relative humidity fields were shown to be quite sensitive to the prescribed profile, and the use of a profile based on the AIRS-derived proxy results in improvements relative to observational estimates. The AIRS-guided total water PDF profiles, including their dependence on underlying surface type and on horizontal resolution, have been implemented in the version of the GEOS-5 AGCM used for publicly released simulations.

  1. PDF added value of a high resolution climate simulation for precipitation

    NASA Astrophysics Data System (ADS)

    Soares, Pedro M. M.; Cardoso, Rita M.

    2015-04-01

    General Circulation Models (GCMs) are models suitable to study the global atmospheric system, its evolution and response to changes in external forcing, namely to increasing emissions of CO2. However, the resolution of GCMs, of the order of 1o, is not sufficient to reproduce finer scale features of the atmospheric flow related to complex topography, coastal processes and boundary layer processes, and higher resolution models are needed to describe observed weather and climate. The latter are known as Regional Climate Models (RCMs) and are widely used to downscale GCMs results for many regions of the globe and are able to capture physically consistent regional and local circulations. Most of the RCMs evaluations rely on the comparison of its results with observations, either from weather stations networks or regular gridded datasets, revealing the ability of RCMs to describe local climatic properties, and assuming most of the times its higher performance in comparison with the forcing GCMs. The additional climatic details given by RCMs when compared with the results of the driving models is usually named as added value, and it's evaluation is still scarce and controversial in the literuature. Recently, some studies have proposed different methodologies to different applications and processes to characterize the added value of specific RCMs. A number of examples reveal that some RCMs do add value to GCMs in some properties or regions, and also the opposite, elighnening that RCMs may add value to GCM resuls, but improvements depend basically on the type of application, model setup, atmospheric property and location. The precipitation can be characterized by histograms of daily precipitation, or also known as probability density functions (PDFs). There are different strategies to evaluate the quality of both GCMs and RCMs in describing the precipitation PDFs when compared to observations. Here, we present a new method to measure the PDF added value obtained from

  2. External intermittency prediction using AMR solutions of RANS turbulence and transported PDF models

    NASA Astrophysics Data System (ADS)

    Olivieri, D. A.; Fairweather, M.; Falle, S. A. E. G.

    2011-12-01

    External intermittency in turbulent round jets is predicted using a Reynolds-averaged Navier-Stokes modelling approach coupled to solutions of the transported probability density function (pdf) equation for scalar variables. Solutions to the descriptive equations are obtained using a finite-volume method, combined with an adaptive mesh refinement algorithm, applied in both physical and compositional space. This method contrasts with conventional approaches to solving the transported pdf equation which generally employ Monte Carlo techniques. Intermittency-modified eddy viscosity and second-moment turbulence closures are used to accommodate the effects of intermittency on the flow field, with the influence of intermittency also included, through modifications to the mixing model, in the transported pdf equation. Predictions of the overall model are compared with experimental data on the velocity and scalar fields in a round jet, as well as against measurements of intermittency profiles and scalar pdfs in a number of flows, with good agreement obtained. For the cases considered, predictions based on the second-moment turbulence closure are clearly superior, although both turbulence models give realistic predictions of the bimodal scalar pdfs observed experimentally.

  3. Publications - PDF 97-29G | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 97-29G Publication Details Title: Rock geochemistry from the Rampart mining district , K.H., Bundtzen, T.K., Newberry, R.J., Dover, J.H., and Blodgett, R.B., 1997, Rock geochemistry from

  4. PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit.

    PubMed

    Parisky, Katherine M; Agosto, Jose; Pulver, Stefan R; Shang, Yuhua; Kuklin, Elena; Hodge, James J L; Kang, Kyeongjin; Kang, Keongjin; Liu, Xu; Garrity, Paul A; Rosbash, Michael; Griffith, Leslie C

    2008-11-26

    Daily sleep cycles in humans are driven by a complex circuit within which GABAergic sleep-promoting neurons oppose arousal. Drosophila sleep has recently been shown to be controlled by GABA, which acts on unknown cells expressing the Rdl GABAA receptor. We identify here the relevant Rdl-containing cells as PDF-expressing small and large ventral lateral neurons (LNvs) of the circadian clock. LNv activity regulates total sleep as well as the rate of sleep onset; both large and small LNvs are part of the sleep circuit. Flies mutant for pdf or its receptor are hypersomnolent, and PDF acts on the LNvs themselves to control sleep. These features of the Drosophila sleep circuit, GABAergic control of onset and maintenance as well as peptidergic control of arousal, support the idea that features of sleep-circuit architecture as well as the mechanisms governing the behavioral transitions between sleep and wake are conserved between mammals and insects.

  5. Identification of a new peptide deformylase gene from enterococcus faecium and establishment of a new screening model targeted on PDF for novel antibiotics.

    PubMed

    Tang, Xian-Bing; Si, Shu-Yi; Zhang, Yue-Qin

    2004-09-01

    To identify a new peptide deformylase (PDF) gene (Genebank Accession AY238515) from Enterococcus faecium and to establish a new screening model targeted on PDF. A new PDF gene was identified by BLAST analysis and PCR and was subsequently over-expressed in the prokaryotic expression host E. coli B121(DE3). Over-expressed protein was purified for enzymatic assay by metal affinity chromatography and a new screening model was established for novel antibiotics. A new PDF gene of Enterococcus faecium was identified successfully. Ten positive samples were picked up from 8000 compound library and the microbial fermentation broth samples. A new PDF of gene Enterococcus faecium was first identified and the model had a high efficacy. Positive samples screened may be antibacterial agents of broad spectrum.

  6. The G3 Experience with Electronic Publishing: An Editor's Perspective

    NASA Astrophysics Data System (ADS)

    White, W. M.

    2003-12-01

    G3 (Geochemistry, Geophysics, Geosystems) is an all-electronic journal published jointly by the AGU, the Geochemical Society, and the European Association of Geochemistry. G3 publishes original scientific contributions pertaining to understanding the Earth as a system, including relevant observational, experimental, and theoretical investigations of the solid Earth, hydrosphere, atmosphere, and biosphere. The journal was initiated as a result of a grass roots effort with the following goals in mind: a copyright policy designed to enhance, rather than inhibit, the dissemination of scientific information (for example, allowing authors to post electronic reprints on their web sites), provide a means of publishing, in immediately useable formats, large data sets, provide a means for ready dissemination of computer modeling and analysis tools, and provide a forum where authors could use novel ways of illustrating both data and models (e.g., formats such as movies, virtual reality images, sound, mathematical models, etc.), and finally to reduce costs and speed publication. In most respects, G3 has been enormously successful and has met most of its goals. G3 began publishing in December of 1999; in the subsequent 3 1/2 years 625 papers have been submitted to it and 325 have been published. It currently has over 600 institutional and personal subscribers. Papers are submitted through the web (a variety of formats are accepted, however, Microsoft Word is most common) and are converted to Adobe pdf format for peer review. Except that it is fully electronic using the web and e-mail, the peer review process is traditional, which insures the quality of the papers published. Accepted papers are copyedited and converted to SGML for archival purposes. HTML and Acrobat pdf versions are then generated from the SGML and published as they are ready on the G3 web site (www.g-cubed.org). Large data sets are routinely published in digital formats that can be readily downloaded by readers

  7. Monte Carlo PDF method for turbulent reacting flow in a jet-stirred reactor

    NASA Astrophysics Data System (ADS)

    Roekaerts, D.

    1992-01-01

    A stochastic algorithm for the solution of the modeled scalar probability density function (PDF) transport equation for single-phase turbulent reacting flow is described. Cylindrical symmetry is assumed. The PDF is represented by ensembles of N representative values of the thermochemical variables in each cell of a nonuniform finite-difference grid and operations on these elements representing convection, diffusion, mixing and reaction are derived. A simplified model and solution algorithm which neglects the influence of turbulent fluctuations on mean reaction rates is also described. Both algorithms are applied to a selectivity problem in a real reactor.

  8. 75 FR 52267 - Waiver of Statement of Account Filing Deadline for the 2010/1 Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    ... available in a print format, a PDF format, and a software ``fill-in'' format created by Gralin Associates... retransmission of multicast streams. The paper and PDF versions of the form have been available to cable... recognize that the paper and PDF versions of the SOA have been available since July, many large and small...

  9. Presentation and response timing accuracy in Adobe Flash and HTML5/JavaScript Web experiments.

    PubMed

    Reimers, Stian; Stewart, Neil

    2015-06-01

    Web-based research is becoming ubiquitous in the behavioral sciences, facilitated by convenient, readily available participant pools and relatively straightforward ways of running experiments: most recently, through the development of the HTML5 standard. Although in most studies participants give untimed responses, there is a growing interest in being able to record response times online. Existing data on the accuracy and cross-machine variability of online timing measures are limited, and generally they have compared behavioral data gathered on the Web with similar data gathered in the lab. For this article, we took a more direct approach, examining two ways of running experiments online-Adobe Flash and HTML5 with CSS3 and JavaScript-across 19 different computer systems. We used specialist hardware to measure stimulus display durations and to generate precise response times to visual stimuli in order to assess measurement accuracy, examining effects of duration, browser, and system-to-system variability (such as across different Windows versions), as well as effects of processing power and graphics capability. We found that (a) Flash and JavaScript's presentation and response time measurement accuracy are similar; (b) within-system variability is generally small, even in low-powered machines under high load; (c) the variability of measured response times across systems is somewhat larger; and (d) browser type and system hardware appear to have relatively small effects on measured response times. Modeling of the effects of this technical variability suggests that for most within- and between-subjects experiments, Flash and JavaScript can both be used to accurately detect differences in response times across conditions. Concerns are, however, noted about using some correlational or longitudinal designs online.

  10. PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.

    PubMed

    Barrios, Arantza; Ghosh, Rajarshi; Fang, Chunhui; Emmons, Scott W; Barr, Maureen M

    2012-12-01

    Appetitive behaviors require complex decision making that involves the integration of environmental stimuli and physiological needs. C. elegans mate searching is a male-specific exploratory behavior regulated by two competing needs: food and reproductive appetite. We found that the pigment dispersing factor receptor (PDFR-1) modulates the circuit that encodes the male reproductive drive that promotes male exploration following mate deprivation. PDFR-1 and its ligand, PDF-1, stimulated mate searching in the male, but not in the hermaphrodite. pdf-1 was required in the gender-shared interneuron AIM, and the receptor acted in internal and external environment-sensing neurons of the shared nervous system (URY, PQR and PHA) to produce mate-searching behavior. Thus, the pdf-1 and pdfr-1 pathway functions in non-sex-specific neurons to produce a male-specific, goal-oriented exploratory behavior. Our results indicate that secretin neuropeptidergic signaling is involved in regulating motivational internal states.

  11. Offline modeling for product quality prediction of mineral processing using modeling error PDF shaping and entropy minimization.

    PubMed

    Ding, Jinliang; Chai, Tianyou; Wang, Hong

    2011-03-01

    This paper presents a novel offline modeling for product quality prediction of mineral processing which consists of a number of unit processes in series. The prediction of the product quality of the whole mineral process (i.e., the mixed concentrate grade) plays an important role and the establishment of its predictive model is a key issue for the plantwide optimization. For this purpose, a hybrid modeling approach of the mixed concentrate grade prediction is proposed, which consists of a linear model and a nonlinear model. The least-squares support vector machine is adopted to establish the nonlinear model. The inputs of the predictive model are the performance indices of each unit process, while the output is the mixed concentrate grade. In this paper, the model parameter selection is transformed into the shape control of the probability density function (PDF) of the modeling error. In this context, both the PDF-control-based and minimum-entropy-based model parameter selection approaches are proposed. Indeed, this is the first time that the PDF shape control idea is used to deal with system modeling, where the key idea is to turn model parameters so that either the modeling error PDF is controlled to follow a target PDF or the modeling error entropy is minimized. The experimental results using the real plant data and the comparison of the two approaches are discussed. The results show the effectiveness of the proposed approaches.

  12. Computations of steady-state and transient premixed turbulent flames using pdf methods

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hulek, T.; Lindstedt, R.P.

    1996-03-01

    Premixed propagating turbulent flames are modeled using a one-point, single time, joint velocity-composition probability density function (pdf) closure. The pdf evolution equation is solved using a Monte Carlo method. The unclosed terms in the pdf equation are modeled using a modified version of the binomial Langevin model for scalar mixing of Valino and Dopazo, and the Haworth and Pope (HP) and Lagrangian Speziale-Sarkar-Gatski (LSSG) models for the viscous dissipation of velocity and the fluctuating pressure gradient. The source terms for the presumed one-step chemical reaction are extracted from the rate of fuel consumption in laminar premixed hydrocarbon flames, computed usingmore » a detailed chemical kinetic mechanism. Steady-state and transient solutions are obtained for planar turbulent methane-air and propane-air flames. The transient solution method features a coupling with a Finite Volume (FV) code to obtain the mean pressure field. The results are compared with the burning velocity measurements of Abdel-Gayed et al. and with velocity measurements obtained in freely propagating propane-air flames by Videto and Santavicca. The effects of different upstream turbulence fields, chemical source terms (different fuels and strained/unstrained laminar flames) and the influence of the velocity statistics models (HP and LSSG) are assessed.« less

  13. The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation.

    PubMed

    Grzela, Renata; Nusbaum, Julien; Fieulaine, Sonia; Lavecchia, Francesco; Bienvenut, Willy V; Dian, Cyril; Meinnel, Thierry; Giglione, Carmela

    2017-09-08

    Prokaryotic proteins must be deformylated before the removal of their first methionine. Peptide deformylase (PDF) is indispensable and guarantees this mechanism. Recent metagenomics studies revealed new idiosyncratic PDF forms as the most abundant family of viral sequences. Little is known regarding these viral PDFs, including the capacity of the corresponding encoded proteins to ensure deformylase activity. We provide here the first evidence that viral PDFs, including the shortest PDF identified to date, Vp16 PDF, display deformylase activity in vivo, despite the absence of the key ribosome-interacting C-terminal region. Moreover, characterization of phage Vp16 PDF underscores unexpected structural and molecular features with the C-terminal Isoleucine residue significantly contributing to deformylase activity both in vitro and in vivo. This residue fully compensates for the absence of the usual long C-domain. Taken together, these data elucidate an unexpected mechanism of enzyme natural evolution and adaptation within viral sequences.

  14. R6 FIFRA e-Notice of Arrival

    EPA Pesticide Factsheets

    This database processes approximately 3,000 Notice of Arrival (NOA) reporting forms from importers and exporters of pesticide products. This is an electronic version of the EPA Form 3540-1. The external user fills out the NOA and submits it electronically. The form is then processed by the Pesticides section and either approved or disapproved. The system then generates an Adobe PDF version of the EPA Form 3540-1 with signature or disapproval and emailed to the external user. The e-filing system eliminates the need for the Region to invest in paper, copying, storage and mailing expenses, while at the same time allowing the regulated community to conduct its business with us in a more expeditious manner.

  15. Using OpenOffice as a Portable Interface to JAVA-Based Applications

    NASA Astrophysics Data System (ADS)

    Comeau, T.; Garrett, B.; Richon, J.; Romelfanger, F.

    2004-07-01

    STScI previously used Microsoft Word and Microsoft Access, a Sybase ODBC driver, and the Adobe Acrobat PDF writer, along with a substantial amount of Visual Basic, to generate a variety of documents for the internal Space Telescope Grants Administration System (STGMS). While investigating an upgrade to Microsoft Office XP, we began considering alternatives, ultimately selecting an open source product, OpenOffice.org. This reduces the total number of products required to operate the internal STGMS system, simplifies the build system, and opens the possibility of moving to a non-Windows platform. We describe the experience of moving from Microsoft Office to OpenOffice.org, and our other internal uses of OpenOffice.org in our development environment.

  16. PDF as a coupling mediator between the light-entrainable and temperature-entrainable clocks in Drosophila melanogaster.

    PubMed

    Tomioka, K; Miyasako, Y; Umezaki, Y

    2008-01-01

    Drosophila shows bimodal circadian locomotor rhythms with peaks around light-on (morning peak) and before light-off (evening peak). The rhythm synchronizes to light and temperature cycles and the synchronization is achieved by two sets of clocks: one entrains to light cycles and the other to temperature cycles. The light-entrainable clock consists of the clock neurons located in the lateral protocerebrum (LNs) and the temperature-entrainable clock involves those located in the dorsal protocerebrum (DNs) and the cells located in the posterior lateral protocerebrum (LPNs). To understand the interaction between the light-entrainable and the temperature-entrainable clock neurons, locomotor rhythms of the mutant flies lacking PDF or PDF-positive clock neurons were examined. Under the light cycles, they showed altered phase of the evening peak. When exposed to temperature cycles of lower temperature levels, the onset of evening peak showed larger advance in contrast to those of wild-type flies. The termination of the peak also advanced while that of wild-type flies remained almost at the same phase as in the constant temperature. These results support our hypothesis that the PDF-positive light entrainable cells regulate the phase of the temperature entrainable cells to be synchronized to their own phase using PDF as a coupling mediator.

  17. NASA Standard for Airborne Data: ICARTT Format ESDS-RFC-019

    NASA Astrophysics Data System (ADS)

    Thornhill, A.; Brown, C.; Aknan, A.; Crawford, J. H.; Chen, G.; Williams, E. J.

    2011-12-01

    Airborne field studies generate a plethora of data products in the effort to study atmospheric composition and processes. Data file formats for airborne field campaigns are designed to present data in an understandable and organized way to support collaboration and to document relevant and important meta data. The ICARTT file format was created to facilitate data management during the International Consortium for Atmospheric Research on Transport and Transformation (ICARTT) campaign in 2004 that involved government-agencies and university participants from five countries. Since this mission the ICARTT format has been used in subsequent field campaigns such as Polar Study Using Aircraft Remote Sensing, Surface Measurements and Models of Climates, Chemistry, Aerosols, and Transport (POLARCAT) and the first phase of Deriving Information on Surface Conditions from COlumn and VERtically Resolved Observations Relevant to Air Quality (DISCOVER-AQ). The ICARTT file format has been endorsed as a standard format for airborne data by the Standard Process Group (SPG), one of the Earth Science Data Systems Working Groups (ESDSWG) in 2010. The detailed description of the ICARTT format can be found at http://www-air.larc.nasa.gov/missions/etc/ESDS-RFC-019-v1.00.pdf. The ICARTT data format is an ASCII, comma delimited format that was based on the NASA Ames and GTE file formats. The file header is detailed enough to fully describe the data for users outside of the instrument group and includes a description of the meta data. The ICARTT scanning tools, format structure, implementations, and examples will be presented.

  18. Comparisons of Lagrangian and Eulerian PDF methods in simulations of non-premixed turbulent jet flames with moderate-to-strong turbulence-chemistry interactions

    NASA Astrophysics Data System (ADS)

    Jaishree, J.; Haworth, D. C.

    2012-06-01

    Transported probability density function (PDF) methods have been applied widely and effectively for modelling turbulent reacting flows. In most applications of PDF methods to date, Lagrangian particle Monte Carlo algorithms have been used to solve a modelled PDF transport equation. However, Lagrangian particle PDF methods are computationally intensive and are not readily integrated into conventional Eulerian computational fluid dynamics (CFD) codes. Eulerian field PDF methods have been proposed as an alternative. Here a systematic comparison is performed among three methods for solving the same underlying modelled composition PDF transport equation: a consistent hybrid Lagrangian particle/Eulerian mesh (LPEM) method, a stochastic Eulerian field (SEF) method and a deterministic Eulerian field method with a direct-quadrature-method-of-moments closure (a multi-environment PDF-MEPDF method). The comparisons have been made in simulations of a series of three non-premixed, piloted methane-air turbulent jet flames that exhibit progressively increasing levels of local extinction and turbulence-chemistry interactions: Sandia/TUD flames D, E and F. The three PDF methods have been implemented using the same underlying CFD solver, and results obtained using the three methods have been compared using (to the extent possible) equivalent physical models and numerical parameters. Reasonably converged mean and rms scalar profiles are obtained using 40 particles per cell for the LPEM method or 40 Eulerian fields for the SEF method. Results from these stochastic methods are compared with results obtained using two- and three-environment MEPDF methods. The relative advantages and disadvantages of each method in terms of accuracy and computational requirements are explored and identified. In general, the results obtained from the two stochastic methods (LPEM and SEF) are very similar, and are in closer agreement with experimental measurements than those obtained using the MEPDF method

  19. Development and characterization of two cell lines PDF and PDH from Puntius denisonii (Day 1865).

    PubMed

    Lakra, Wazir S; Goswami, M; Yadav, Kamalendra; Gopalakrishnan, A; Patiyal, R S; Singh, M

    2011-02-01

    The Puntius denisonii colloquially and more popularly referred to as Miss Kerala is a subtropical fish belonging to the genus Puntius (Barb) and family Cyprinidae. Two cell lines PDF and PDH were developed from the caudal fin and heart of P. denisonii, respectively. The cell lines were optimally maintained at 26°C in Leibovitz-15 medium supplemented with 10% fetal bovine serum. A diploid count of 50 chromosomes at passage 50 was observed in both the cell lines. The high growth potential of the cell lines was reflected from the cell doubling time of 28 and 30 h of PDF and PDH cell lines, respectively. The viability of the PDF and PDH cell lines was 70% and 76%, respectively, after 4 mo of storage in liquid nitrogen (-196°C). The origin of the cell lines was confirmed by the amplification of 653 bp fragments of cytochrome oxidase subunit I of mitochondrial DNA genes.

  20. A consistent transported PDF model for treating differential molecular diffusion

    NASA Astrophysics Data System (ADS)

    Wang, Haifeng; Zhang, Pei

    2016-11-01

    Differential molecular diffusion is a fundamentally significant phenomenon in all multi-component turbulent reacting or non-reacting flows caused by the different rates of molecular diffusion of energy and species concentrations. In the transported probability density function (PDF) method, the differential molecular diffusion can be treated by using a mean drift model developed by McDermott and Pope. This model correctly accounts for the differential molecular diffusion in the scalar mean transport and yields a correct DNS limit of the scalar variance production. The model, however, misses the molecular diffusion term in the scalar variance transport equation, which yields an inconsistent prediction of the scalar variance in the transported PDF method. In this work, a new model is introduced to remedy this problem that can yield a consistent scalar variance prediction. The model formulation along with its numerical implementation is discussed, and the model validation is conducted in a turbulent mixing layer problem.

  1. Maximum entropy PDF projection: A review

    NASA Astrophysics Data System (ADS)

    Baggenstoss, Paul M.

    2017-06-01

    We review maximum entropy (MaxEnt) PDF projection, a method with wide potential applications in statistical inference. The method constructs a sampling distribution for a high-dimensional vector x based on knowing the sampling distribution p(z) of a lower-dimensional feature z = T (x). Under mild conditions, the distribution p(x) having highest possible entropy among all distributions consistent with p(z) may be readily found. Furthermore, the MaxEnt p(x) may be sampled, making the approach useful in Monte Carlo methods. We review the theorem and present a case study in model order selection and classification for handwritten character recognition.

  2. A Electronic Map Data Model Based on PDF

    NASA Astrophysics Data System (ADS)

    Zhou, Xiaodong; Yang, Chuncheng; Meng, Nina; Peng, Peng

    2018-05-01

    In this paper, we proposed the PDFEMAP (PDF electronic map) that is a kind of new electronic map products aiming at the current situation and demand of the use of electronic map products. Firstly gives the definition and characteristics of PDFEMAP, followed by a detailed description of the data model and method for generating PDFEMAP, and finally expounds application modes of the PDFEMAP which feasibility and effectiveness are verified.

  3. Oscillating PDF in termini of circadian pacemaker neurons and synchronous molecular clocks in downstream neurons are not sufficient for sustenance of activity rhythms in constant darkness.

    PubMed

    Prakash, Pavitra; Nambiar, Aishwarya; Sheeba, Vasu

    2017-01-01

    In Drosophila, neuropeptide Pigment Dispersing Factor (PDF) is expressed in small and large ventral Lateral Neurons (sLNv and lLNv), among which sLNv are critical for activity rhythms in constant darkness. Studies show that this is mediated by rhythmic accumulation and likely secretion of PDF from sLNv dorsal projections, which in turn synchronises molecular oscillations in downstream circadian neurons. Using targeted expression of a neurodegenerative protein Huntingtin in LNv, we evoke a selective loss of neuropeptide PDF and clock protein PERIOD from sLNv soma. However, PDF is not lost from sLNv dorsal projections and lLNv. These flies are behaviourally arrhythmic in constant darkness despite persistence of PDF oscillations in sLNv dorsal projections and synchronous PERIOD oscillations in downstream circadian neurons. We find that PDF oscillations in sLNv dorsal projections are not sufficient for sustenance of activity rhythms in constant darkness and this is suggestive of an additional component that is possibly dependent on sLNv molecular clock and PDF in sLNv soma. Additionally, despite loss of PERIOD in sLNv, their activity rhythms entrain to light/dark cycles indicating that sLNv molecular clocks are not necessary for entrainment. Under constant light, these flies lack PDF from both soma and dorsal projections of sLNv, and when subjected to light/dark cycles, show morning and evening anticipation and accurately phased morning and evening peaks. Thus, under light/dark cycles, PDF in sLNv is not necessary for morning anticipation.

  4. Oscillating PDF in termini of circadian pacemaker neurons and synchronous molecular clocks in downstream neurons are not sufficient for sustenance of activity rhythms in constant darkness

    PubMed Central

    Prakash, Pavitra; Nambiar, Aishwarya; Sheeba, Vasu

    2017-01-01

    In Drosophila, neuropeptide Pigment Dispersing Factor (PDF) is expressed in small and large ventral Lateral Neurons (sLNv and lLNv), among which sLNv are critical for activity rhythms in constant darkness. Studies show that this is mediated by rhythmic accumulation and likely secretion of PDF from sLNv dorsal projections, which in turn synchronises molecular oscillations in downstream circadian neurons. Using targeted expression of a neurodegenerative protein Huntingtin in LNv, we evoke a selective loss of neuropeptide PDF and clock protein PERIOD from sLNv soma. However, PDF is not lost from sLNv dorsal projections and lLNv. These flies are behaviourally arrhythmic in constant darkness despite persistence of PDF oscillations in sLNv dorsal projections and synchronous PERIOD oscillations in downstream circadian neurons. We find that PDF oscillations in sLNv dorsal projections are not sufficient for sustenance of activity rhythms in constant darkness and this is suggestive of an additional component that is possibly dependent on sLNv molecular clock and PDF in sLNv soma. Additionally, despite loss of PERIOD in sLNv, their activity rhythms entrain to light/dark cycles indicating that sLNv molecular clocks are not necessary for entrainment. Under constant light, these flies lack PDF from both soma and dorsal projections of sLNv, and when subjected to light/dark cycles, show morning and evening anticipation and accurately phased morning and evening peaks. Thus, under light/dark cycles, PDF in sLNv is not necessary for morning anticipation. PMID:28558035

  5. Understanding star formation in molecular clouds. II. Signatures of gravitational collapse of IRDCs

    NASA Astrophysics Data System (ADS)

    Schneider, N.; Csengeri, T.; Klessen, R. S.; Tremblin, P.; Ossenkopf, V.; Peretto, N.; Simon, R.; Bontemps, S.; Federrath, C.

    2015-06-01

    We analyse column density and temperature maps derived from Herschel dust continuum observations of a sample of prominent, massive infrared dark clouds (IRDCs) i.e. G11.11-0.12, G18.82-0.28, G28.37+0.07, and G28.53-0.25. We disentangle the velocity structure of the clouds using 13CO 1→0 and 12CO 3→2 data, showing that these IRDCs are the densest regions in massive giant molecular clouds (GMCs) and not isolated features. The probability distribution function (PDF) of column densities for all clouds have a power-law distribution over all (high) column densities, regardless of the evolutionary stage of the cloud: G11.11-0.12, G18.82-0.28, and G28.37+0.07 contain (proto)-stars, while G28.53-0.25 shows no signs of star formation. This is in contrast to the purely log-normal PDFs reported for near and/or mid-IR extinction maps. We only find a log-normal distribution for lower column densities, if we perform PDFs of the column density maps of the whole GMC in which the IRDCs are embedded. By comparing the PDF slope and the radial column density profile of three of our clouds, we attribute the power law to the effect of large-scale gravitational collapse and to local free-fall collapse of pre- and protostellar cores for the highest column densities. A significant impact on the cloud properties from radiative feedback is unlikely because the clouds are mostly devoid of star formation. Independent from the PDF analysis, we find infall signatures in the spectral profiles of 12CO for G28.37+0.07 and G11.11-0.12, supporting the scenario of gravitational collapse. Our results are in line with earlier interpretations that see massive IRDCs as the densest regions within GMCs, which may be the progenitors of massive stars or clusters. At least some of the IRDCs are probably the same features as ridges (high column density regions with N> 1023 cm-2 over small areas), which were defined for nearby IR-bright GMCs. Because IRDCs are only confined to the densest (gravity dominated

  6. EUPDF-II: An Eulerian Joint Scalar Monte Carlo PDF Module : User's Manual

    NASA Technical Reports Server (NTRS)

    Raju, M. S.; Liu, Nan-Suey (Technical Monitor)

    2004-01-01

    EUPDF-II provides the solution for the species and temperature fields based on an evolution equation for PDF (Probability Density Function) and it is developed mainly for application with sprays, combustion, parallel computing, and unstructured grids. It is designed to be massively parallel and could easily be coupled with any existing gas-phase CFD and spray solvers. The solver accommodates the use of an unstructured mesh with mixed elements of either triangular, quadrilateral, and/or tetrahedral type. The manual provides the user with an understanding of the various models involved in the PDF formulation, its code structure and solution algorithm, and various other issues related to parallelization and its coupling with other solvers. The source code of EUPDF-II will be available with National Combustion Code (NCC) as a complete package.

  7. Regional seismic lines reprocessed using post-stack processing techniques; National Petroleum Reserve, Alaska

    USGS Publications Warehouse

    Miller, John J.; Agena, W.F.; Lee, M.W.; Zihlman, F.N.; Grow, J.A.; Taylor, D.J.; Killgore, Michele; Oliver, H.L.

    2000-01-01

    This CD-ROM contains stacked, migrated, 2-Dimensional seismic reflection data and associated support information for 22 regional seismic lines (3,470 line-miles) recorded in the National Petroleum Reserve ? Alaska (NPRA) from 1974 through 1981. Together, these lines constitute about one-quarter of the seismic data collected as part of the Federal Government?s program to evaluate the petroleum potential of the Reserve. The regional lines, which form a grid covering the entire NPRA, were created by combining various individual lines recorded in different years using different recording parameters. These data were reprocessed by the USGS using modern, post-stack processing techniques, to create a data set suitable for interpretation on interactive seismic interpretation computer workstations. Reprocessing was done in support of ongoing petroleum resource studies by the USGS Energy Program. The CD-ROM contains the following files: 1) 22 files containing the digital seismic data in standard, SEG-Y format; 2) 1 file containing navigation data for the 22 lines in standard SEG-P1 format; 3) 22 small scale graphic images of each seismic line in Adobe Acrobat? PDF format; 4) a graphic image of the location map, generated from the navigation file, with hyperlinks to the graphic images of the seismic lines; 5) an ASCII text file with cross-reference information for relating the sequential trace numbers on each regional line to the line number and shotpoint number of the original component lines; and 6) an explanation of the processing used to create the final seismic sections (this document). The SEG-Y format seismic files and SEG-P1 format navigation file contain all the information necessary for loading the data onto a seismic interpretation workstation.

  8. Ultrasonic Nondestructive Evaluation Techniques Applied to the Quantitative Characterization of Textile Composite Materials

    NASA Technical Reports Server (NTRS)

    Miller, James G.

    1997-01-01

    In this Progress Report, we describe our further development of advanced ultrasonic nondestructive evaluation methods applied to the characterization of anisotropic materials. We present images obtained from experimental measurements of ultrasonic diffraction patterns transmitted through water only and transmitted through water and a thin woven composite. All images of diffraction patterns have been included on the accompanying CD-ROM in the JPEG format and Adobe TM Portable Document Format (PDF), in addition to the inclusion of hardcopies of the images contained in this report. In our previous semi-annual Progress Report (NAG 1-1848, December, 1996), we proposed a simple model to simulate the effect of a thin woven composite on an insonifying ultrasonic pressure field. This initial approach provided an avenue to begin development of a robust measurement method for nondestructive evaluation of anisotropic materials. In this Progress Report, we extend that work by performing experimental measurements on a single layer of a five-harness biaxial woven composite to investigate how a thin, yet architecturally complex, material interacts with the insonifying ultrasonic field. In Section 2 of this Progress Report we describe the experimental arrangement and methods for data acquisition of the ultrasonic diffraction patterns upon transmission through a thin woven composite. We also briefly describe the thin composite specimen investigated. Section 3 details the analysis of the experimental data followed by the experimental results in Section 4. Finally, a discussion of the observations and conclusions is found in Section 5.

  9. Pdf prediction of supersonic hydrogen flames

    NASA Technical Reports Server (NTRS)

    Eifler, P.; Kollmann, W.

    1993-01-01

    A hybrid method for the prediction of supersonic turbulent flows with combustion is developed consisting of a second order closure for the velocity field and a multi-scalar pdf method for the local thermodynamic state. It is shown that for non-premixed flames and chemical equilibrium mixture fraction, the logarithm of the (dimensionless) density, internal energy per unit mass and the divergence of the velocity have several advantages over other sets of scalars. The closure model is applied to a supersonic non-premixed flame burning hydrogen with air supplied by a supersonic coflow and the results are compared with a limited set of experimental data.

  10. Multiresolution MAP despeckling of SAR images based on locally adaptive generalized Gaussian pdf modeling.

    PubMed

    Argenti, Fabrizio; Bianchi, Tiziano; Alparone, Luciano

    2006-11-01

    In this paper, a new despeckling method based on undecimated wavelet decomposition and maximum a posteriori MIAP) estimation is proposed. Such a method relies on the assumption that the probability density function (pdf) of each wavelet coefficient is generalized Gaussian (GG). The major novelty of the proposed approach is that the parameters of the GG pdf are taken to be space-varying within each wavelet frame. Thus, they may be adjusted to spatial image context, not only to scale and orientation. Since the MAP equation to be solved is a function of the parameters of the assumed pdf model, the variance and shape factor of the GG function are derived from the theoretical moments, which depend on the moments and joint moments of the observed noisy signal and on the statistics of speckle. The solution of the MAP equation yields the MAP estimate of the wavelet coefficients of the noise-free image. The restored SAR image is synthesized from such coefficients. Experimental results, carried out on both synthetic speckled images and true SAR images, demonstrate that MAP filtering can be successfully applied to SAR images represented in the shift-invariant wavelet domain, without resorting to a logarithmic transformation.

  11. A novel background field removal method for MRI using projection onto dipole fields (PDF).

    PubMed

    Liu, Tian; Khalidov, Ildar; de Rochefort, Ludovic; Spincemaille, Pascal; Liu, Jing; Tsiouris, A John; Wang, Yi

    2011-11-01

    For optimal image quality in susceptibility-weighted imaging and accurate quantification of susceptibility, it is necessary to isolate the local field generated by local magnetic sources (such as iron) from the background field that arises from imperfect shimming and variations in magnetic susceptibility of surrounding tissues (including air). Previous background removal techniques have limited effectiveness depending on the accuracy of model assumptions or information input. In this article, we report an observation that the magnetic field for a dipole outside a given region of interest (ROI) is approximately orthogonal to the magnetic field of a dipole inside the ROI. Accordingly, we propose a nonparametric background field removal technique based on projection onto dipole fields (PDF). In this PDF technique, the background field inside an ROI is decomposed into a field originating from dipoles outside the ROI using the projection theorem in Hilbert space. This novel PDF background removal technique was validated on a numerical simulation and a phantom experiment and was applied in human brain imaging, demonstrating substantial improvement in background field removal compared with the commonly used high-pass filtering method. Copyright © 2011 John Wiley & Sons, Ltd.

  12. Revised estimates for continuous shoreline fumigation: a PDF approach.

    PubMed

    Nazir, Muddassir; Khan, Faisal I; Husain, Tahir

    2005-02-14

    A probability density function (PDF) fumigation model is presented here to study the dispersion of air pollutants emitted from a tall stack on the shoreline. This work considers dispersion of the pollutants in the stable layer and within the thermal internal boundary layer (TIBL) proceeds independently. The growth of TIBL is considered parabolic with distance inland. Turbulence is taken as homogeneous and stationary. Dispersion of particles (contaminant) in lateral and vertical directions is assumed independent of each other. This assumption allows us to consider the position of particles in both directions as independent random variables. The lateral dispersion distribution within the TIBL is considered as Gaussian and independent of height. A skewed bi-Gaussian vertical velocity PDF is used to account for the physics of dispersion due to different characteristics of updrafts and downdrafts within the TIBL. We have used Weil (J.C. Weil, A diagnosis of the asymmetry in top-down and bottom-up diffusion using a Lagrangian stochastic model, J. Atmos. Sci., 47 (1990) 501-515) solutions to find out the parameters of this PDF. Incorporating finite Lagrangian integral time scale for the vertical velocity component, it is observed that it reduces the vertical dispersion in the beginning and moves the point of maximum concentration further downwind. Due to little dispersion in the beginning, there is more plume to be dispersed causing higher concentrations at large distances. The model has considered Weil and Brower's (J.C. Weil, P.R. Brower, Estimating convective boundary layer parameters for diffusion applications, Maryland Power Plant Siting Program Rep. PPSP-MP-48, Department of Natural Resources, Annapolis, MD, 1985, 37 pp.) convective limit to analyze dispersion characteristics within TIBL. The revised model discussed here is evaluated with the data available from the Nanticoke field experiment on fumigation conducted in summer of 1978 in Ontario, Canada. The results

  13. 75 FR 14401 - Amendment of Certain of the Commission's Rules of Practice and Procedure and Rules of Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-25

    ... were created, such as Microsoft Excel, Microsoft Word, or Microsoft PowerPoint (``native format'')? We... (condensed) or expanded (detailed) format Export search results to Excel or PDF As noted above, system is...., Microsoft Word ``.doc'' format or non-copy protected text- searchable ``.pdf'' format)? Should submissions...

  14. Ionization impact on molecular clouds and star formation. Numerical simulations and observations

    NASA Astrophysics Data System (ADS)

    Tremblin, P.

    2012-11-01

    the molecular cloud, the velocity spectrum of these globules is shifted at different velocities than the velocity of the shell, pillars and clumps that follow the global expansion of the H ii region. An other diagnostic is the impact of the compression on the probability density function (PDF) of the cold gas. The distribution is double peaked when the turbulent ram pressure is low compared to the ionized-gas pressure. This is the signature of the compression caused by the expansion of the ionized bubble. When the turbulence is high, the two peaks merge and the compression can still be identified although the signature is less clear. We have used Herschel column density maps and molecular-line data to characterize the density and velocity structures of the interface between the ionized and the cold gas in several regions: RCW 120, RCW 36, Cygnus X, the Rosette and Eagle Nebulae. In addition to the diagnostics derived from the simulations, analytical predictions of the shell and pillar parameters was tested and confronted to the observations. In all the regions, we have seen that there is a good agreement with the analytical models and with the simulation diagnostics. The velocity structure of a nascent pillar in the Rosette Nebula suggests that it has been formed by the collapse of the shell on itself and the bulk velocity of cometary globules in Cygnus X and in the Rosette Nebula tends to confirm their turbulent origin. The compression caused by the ionized gas can be seen on the PDF of the cold gas in most of the regions studied. This result is important for the link between the IMF and the global prop! erties of the cloud. If the IMF can be derived from the PDF of a cloud, the impact of the massive stars on the PDF has to be taken in account. Furthermore, we present dedicated simulations of RCW 36 that suggest that the dense clumps at the edge of the ionized gas are not pre-existing, it is likely that their formation was triggered by the compression caused by the

  15. A PDF projection method: A pressure algorithm for stand-alone transported PDFs

    NASA Astrophysics Data System (ADS)

    Ghorbani, Asghar; Steinhilber, Gerd; Markus, Detlev; Maas, Ulrich

    2015-03-01

    In this paper, a new formulation of the projection approach is introduced for stand-alone probability density function (PDF) methods. The method is suitable for applications in low-Mach number transient turbulent reacting flows. The method is based on a fractional step method in which first the advection-diffusion-reaction equations are modelled and solved within a particle-based PDF method to predict an intermediate velocity field. Then the mean velocity field is projected onto a space where the continuity for the mean velocity is satisfied. In this approach, a Poisson equation is solved on the Eulerian grid to obtain the mean pressure field. Then the mean pressure is interpolated at the location of each stochastic Lagrangian particle. The formulation of the Poisson equation avoids the time derivatives of the density (due to convection) as well as second-order spatial derivatives. This in turn eliminates the major sources of instability in the presence of stochastic noise that are inherent in particle-based PDF methods. The convergence of the algorithm (in the non-turbulent case) is investigated first by the method of manufactured solutions. Then the algorithm is applied to a one-dimensional turbulent premixed flame in order to assess the accuracy and convergence of the method in the case of turbulent combustion. As a part of this work, we also apply the algorithm to a more realistic flow, namely a transient turbulent reacting jet, in order to assess the performance of the method.

  16. Energy map of southwestern Wyoming, Part A - Coal and wind

    USGS Publications Warehouse

    Biewick, Laura; Jones, Nicholas R.

    2012-01-01

    To further advance the objectives of the Wyoming Landscape Conservation Initiative (WLCI) the U.S. Geological Survey (USGS) and the Wyoming State Geological Survey (WSGS) have compiled Part A of the Energy Map of Southwestern Wyoming. Focusing primarily on electrical power sources, Part A of the energy map is a compilation of both published and previously unpublished coal (including coalbed gas) and wind energy resources data, presented in a Geographic Information System (GIS) data package. Energy maps, data, documentation and spatial data processing capabilities are available in a geodatabase, published map file (pmf), ArcMap document (mxd), Adobe Acrobat PDF map (plate 1) and other digital formats that can be downloaded at the USGS website. Accompanying the map (plate 1) and the geospatial data are four additional plates that describe the geology, energy resources, and related infrastructure. These tabular plates include coal mine (plate 2), coal field (plate 3), coalbed gas assessment unit (plate 4), and wind farm (plate 5) information with hyperlinks to source publications and data on the internet. The plates can be printed and examined in hardcopy, or accessed digitally. The data represent decades of research by the USGS, WSGS, BLM and others, and can facilitate landscape-level science assessments, and resource management decisionmaking.

  17. aMC fast: automation of fast NLO computations for PDF fits

    NASA Astrophysics Data System (ADS)

    Bertone, Valerio; Frederix, Rikkert; Frixione, Stefano; Rojo, Juan; Sutton, Mark

    2014-08-01

    We present the interface between M adG raph5_ aMC@NLO, a self-contained program that calculates cross sections up to next-to-leading order accuracy in an automated manner, and APPL grid, a code that parametrises such cross sections in the form of look-up tables which can be used for the fast computations needed in the context of PDF fits. The main characteristic of this interface, which we dub aMC fast, is its being fully automated as well, which removes the need to extract manually the process-specific information for additional physics processes, as is the case with other matrix-element calculators, and renders it straightforward to include any new process in the PDF fits. We demonstrate this by studying several cases which are easily measured at the LHC, have a good constraining power on PDFs, and some of which were previously unavailable in the form of a fast interface.

  18. Charm and beauty quark masses in the MMHT2014 global PDF analysis.

    PubMed

    Harland-Lang, L A; Martin, A D; Motylinski, P; Thorne, R S

    We investigate the variation in the MMHT2014 PDFs when we allow the heavy-quark masses [Formula: see text] and [Formula: see text] to vary away from their default values. We make PDF sets available in steps of [Formula: see text] and [Formula: see text], and present the variation in the PDFs and in the predictions. We examine the comparison to the HERA data on charm and beauty structure functions and note that in each case the heavy-quark data, and the inclusive data, have a slight preference for lower masses than our default values. We provide PDF sets with three and four active quark flavours, as well as the standard value of five flavours. We use the pole mass definition of the quark masses, as in the default MMHT2014 analysis, but briefly comment on the [Formula: see text] definition.

  19. 78 FR 4766 - Adoption of Updated EDGAR Filer Manual

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ... primarily to introduce the new EDGARLink Online submission type IRANNOTICE; and support PDF as an official... Portable Document Format (PDF) as an official filing format. EDGAR will continue to accept ASCII and HTML...) and 101 (17 CFR 232.101) of Regulation S-T and the EDGAR Filer Manual relating to the use of PDF files...

  20. Transported PDF Modeling of Nonpremixed Turbulent CO/H-2/N-2 Jet Flames

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhao, xinyu; Haworth, D. C.; Huckaby, E. David

    2012-01-01

    Turbulent CO/H{sub 2}/N{sub 2} (“syngas”) flames are simulated using a transported composition probability density function (PDF) method. A consistent hybrid Lagrangian particle/Eulerian mesh algorithm is used to solve the modeled PDF transport equation. The model includes standard k–ϵ turbulence, gradient transport for scalars, and Euclidean minimum spanning tree (EMST) mixing. Sensitivities of model results to variations in the turbulence model, the treatment of radiation heat transfer, the choice of chemical mechanism, and the PDF mixing model are explored. A baseline model reproduces the measured mean and rms temperature, major species, and minor species profiles reasonably well, and captures the scalingmore » that is observed in the experiments. Both our results and the literature suggest that further improvements can be realized with adjustments in the turbulence model, the radiation heat transfer model, and the chemical mechanism. Although radiation effects are relatively small in these flames, consideration of radiation is important for accurate NO prediction. Chemical mechanisms that have been developed specifically for fuels with high concentrations of CO and H{sub 2} perform better than a methane mechanism that was not designed for this purpose. It is important to account explicitly for turbulence–chemistry interactions, although the details of the mixing model do not make a large difference in the results, within reasonable limits.« less

  1. Evolution of the concentration PDF in random environments modeled by global random walk

    NASA Astrophysics Data System (ADS)

    Suciu, Nicolae; Vamos, Calin; Attinger, Sabine; Knabner, Peter

    2013-04-01

    The evolution of the probability density function (PDF) of concentrations of chemical species transported in random environments is often modeled by ensembles of notional particles. The particles move in physical space along stochastic-Lagrangian trajectories governed by Ito equations, with drift coefficients given by the local values of the resolved velocity field and diffusion coefficients obtained by stochastic or space-filtering upscaling procedures. A general model for the sub-grid mixing also can be formulated as a system of Ito equations solving for trajectories in the composition space. The PDF is finally estimated by the number of particles in space-concentration control volumes. In spite of their efficiency, Lagrangian approaches suffer from two severe limitations. Since the particle trajectories are constructed sequentially, the demanded computing resources increase linearly with the number of particles. Moreover, the need to gather particles at the center of computational cells to perform the mixing step and to estimate statistical parameters, as well as the interpolation of various terms to particle positions, inevitably produce numerical diffusion in either particle-mesh or grid-free particle methods. To overcome these limitations, we introduce a global random walk method to solve the system of Ito equations in physical and composition spaces, which models the evolution of the random concentration's PDF. The algorithm consists of a superposition on a regular lattice of many weak Euler schemes for the set of Ito equations. Since all particles starting from a site of the space-concentration lattice are spread in a single numerical procedure, one obtains PDF estimates at the lattice sites at computational costs comparable with those for solving the system of Ito equations associated to a single particle. The new method avoids the limitations concerning the number of particles in Lagrangian approaches, completely removes the numerical diffusion, and

  2. Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain

    PubMed Central

    Shimada, Naoto; Inami, Show; Sato, Shoma; Kitamoto, Toshihiro; Sakai, Takaomi

    2016-01-01

    Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper sleep/wake regulation in adult flies. PDF-expressing neurons consist of two neuronal clusters: small ventral-lateral neurons (s-LNvs) acting as the circadian pacemaker and large ventral-lateral neurons (l-LNvs) regulating light-driven arousal. We identified that Ap localizes to the nuclei of s-LNvs and l-LNvs. In light-dark (LD) cycles, RNAi knockdown or the targeted expression of dominant-negative forms of Ap or Chi in PDF-expressing neurons or l-LNvs promoted arousal. In contrast, in constant darkness, knockdown of Ap in PDF-expressing neurons did not promote arousal, indicating that a reduced Ap function in PDF-expressing neurons promotes light-driven arousal. Furthermore, Ap expression in l-LNvs showed daily rhythms (peaking at midnight), which are generated by a direct light-dependent mechanism rather than by the endogenous clock. These results raise the possibility that the daily oscillation of Ap expression in l-LNvs may contribute to the buffering of light-driven arousal in wild-type flies. PMID:27853240

  3. Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain.

    PubMed

    Shimada, Naoto; Inami, Show; Sato, Shoma; Kitamoto, Toshihiro; Sakai, Takaomi

    2016-11-17

    Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper sleep/wake regulation in adult flies. PDF-expressing neurons consist of two neuronal clusters: small ventral-lateral neurons (s-LNvs) acting as the circadian pacemaker and large ventral-lateral neurons (l-LNvs) regulating light-driven arousal. We identified that Ap localizes to the nuclei of s-LNvs and l-LNvs. In light-dark (LD) cycles, RNAi knockdown or the targeted expression of dominant-negative forms of Ap or Chi in PDF-expressing neurons or l-LNvs promoted arousal. In contrast, in constant darkness, knockdown of Ap in PDF-expressing neurons did not promote arousal, indicating that a reduced Ap function in PDF-expressing neurons promotes light-driven arousal. Furthermore, Ap expression in l-LNvs showed daily rhythms (peaking at midnight), which are generated by a direct light-dependent mechanism rather than by the endogenous clock. These results raise the possibility that the daily oscillation of Ap expression in l-LNvs may contribute to the buffering of light-driven arousal in wild-type flies.

  4. Publications - PDF 94-40 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 94-40 Publication Details Title: Geology of the Gagaryah River area, Lime Hills C-5 and C ., Clautice, K.H., and Harris, E.E., 1994, Geology of the Gagaryah River area, Lime Hills C-5 and C-6 Sheet 1 Geologic map of the Gagaryah River Area, Lime Hills C-5 and C-6 quadrangles, Southwestern Alaska

  5. The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons.

    PubMed

    Vecsey, Christopher G; Pírez, Nicolás; Griffith, Leslie C

    2014-03-01

    Neuropeptides have widespread effects on behavior, but how these molecules alter the activity of their target cells is poorly understood. We employed a new model system in Drosophila melanogaster to assess the electrophysiological and molecular effects of neuropeptides, recording in situ from larval motor neurons, which transgenically express a receptor of choice. We focused on two neuropeptides, pigment-dispersing factor (PDF) and small neuropeptide F (sNPF), which play important roles in sleep/rhythms and feeding/metabolism. PDF treatment depolarized motor neurons expressing the PDF receptor (PDFR), increasing excitability. sNPF treatment had the opposite effect, hyperpolarizing neurons expressing the sNPF receptor (sNPFR). Live optical imaging using a genetically encoded fluorescence resonance energy transfer (FRET)-based sensor for cyclic AMP (cAMP) showed that PDF induced a large increase in cAMP, whereas sNPF caused a small but significant decrease in cAMP. Coexpression of pertussis toxin or RNAi interference to disrupt the G-protein Gαo blocked the electrophysiological responses to sNPF, showing that sNPFR acts via Gαo signaling. Using a fluorescent sensor for intracellular calcium, we observed that sNPF-induced hyperpolarization blocked spontaneous waves of activity propagating along the ventral nerve cord, demonstrating that the electrical effects of sNPF can cause profound changes in natural network activity in the brain. This new model system provides a platform for mechanistic analysis of how neuropeptides can affect target cells at the electrical and molecular level, allowing for predictions of how they regulate brain circuits that control behaviors such as sleep and feeding.

  6. The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons

    PubMed Central

    Vecsey, Christopher G.; Pírez, Nicolás

    2013-01-01

    Neuropeptides have widespread effects on behavior, but how these molecules alter the activity of their target cells is poorly understood. We employed a new model system in Drosophila melanogaster to assess the electrophysiological and molecular effects of neuropeptides, recording in situ from larval motor neurons, which transgenically express a receptor of choice. We focused on two neuropeptides, pigment-dispersing factor (PDF) and small neuropeptide F (sNPF), which play important roles in sleep/rhythms and feeding/metabolism. PDF treatment depolarized motor neurons expressing the PDF receptor (PDFR), increasing excitability. sNPF treatment had the opposite effect, hyperpolarizing neurons expressing the sNPF receptor (sNPFR). Live optical imaging using a genetically encoded fluorescence resonance energy transfer (FRET)-based sensor for cyclic AMP (cAMP) showed that PDF induced a large increase in cAMP, whereas sNPF caused a small but significant decrease in cAMP. Coexpression of pertussis toxin or RNAi interference to disrupt the G-protein Gαo blocked the electrophysiological responses to sNPF, showing that sNPFR acts via Gαo signaling. Using a fluorescent sensor for intracellular calcium, we observed that sNPF-induced hyperpolarization blocked spontaneous waves of activity propagating along the ventral nerve cord, demonstrating that the electrical effects of sNPF can cause profound changes in natural network activity in the brain. This new model system provides a platform for mechanistic analysis of how neuropeptides can affect target cells at the electrical and molecular level, allowing for predictions of how they regulate brain circuits that control behaviors such as sleep and feeding. PMID:24353297

  7. Calibration and data collection protocols for reliable lattice parameter values in electron pair distribution function (ePDF) studies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Abeykoon, A. M. Milinda; Hu, Hefei; Wu, Lijun

    2015-02-01

    We explore and describe different protocols for calibrating electron pair distribution function (ePDF) measurements for quantitative studies on nano-materials. We find the most accurate approach to determine the camera-length is to use a standard calibration sample of Au nanoparticles from National Institute of Standards and Technology. Different protocols for data collection are also explored, as are possible operational errors, to find the best approaches for accurate data collection for quantitative ePDF studies.

  8. Historical rock falls in Yosemite National Park, California (1857-2011)

    USGS Publications Warehouse

    Stock, Greg M.; Collins, Brian D.; Santaniello, David J.; Zimmer, Valerie L.; Wieczorek, Gerald F.; Snyder, James B.

    2013-01-01

    Inventories of rock falls and other types of landslides are valuable tools for improving understanding of these events. For example, detailed information on rock falls is critical for identifying mechanisms that trigger rock falls, for quantifying the susceptibility of different cliffs to rock falls, and for developing magnitude-frequency relations. Further, inventories can assist in quantifying the relative hazard and risk posed by these events over both short and long time scales. This report describes and presents the accompanying rock fall inventory database for Yosemite National Park, California. The inventory database documents 925 events spanning the period 1857–2011. Rock falls, rock slides, and other forms of slope movement represent a serious natural hazard in Yosemite National Park. Rock-fall hazard and risk are particularly relevant in Yosemite Valley, where glacially steepened granitic cliffs approach 1 km in height and where the majority of the approximately 4 million yearly visitors to the park congregate. In addition to damaging roads, trails, and other facilities, rock falls and other slope movement events have killed 15 people and injured at least 85 people in the park since the first documented rock fall in 1857. The accompanying report describes each of the organizational categories in the database, including event location, type of slope movement, date, volume, relative size, probable trigger, impact to humans, narrative description, references, and environmental conditions. The inventory database itself is contained in a Microsoft Excel spreadsheet (Yosemite_rock_fall_database_1857-2011.xlsx). Narrative descriptions of events are contained in the database, but are also provided in a more readable Adobe portable document format (pdf) file (Yosemite_rock_fall_database_narratives_1857-2011.pdf) available for download separate from the database.

  9. Preliminary surficial geologic map database of the Amboy 30 x 60 minute quadrangle, California

    USGS Publications Warehouse

    Bedford, David R.; Miller, David M.; Phelps, Geoffrey A.

    2006-01-01

    The surficial geologic map database of the Amboy 30x60 minute quadrangle presents characteristics of surficial materials for an area approximately 5,000 km2 in the eastern Mojave Desert of California. This map consists of new surficial mapping conducted between 2000 and 2005, as well as compilations of previous surficial mapping. Surficial geology units are mapped and described based on depositional process and age categories that reflect the mode of deposition, pedogenic effects occurring post-deposition, and, where appropriate, the lithologic nature of the material. The physical properties recorded in the database focus on those that drive hydrologic, biologic, and physical processes such as particle size distribution (PSD) and bulk density. This version of the database is distributed with point data representing locations of samples for both laboratory determined physical properties and semi-quantitative field-based information. Future publications will include the field and laboratory data as well as maps of distributed physical properties across the landscape tied to physical process models where appropriate. The database is distributed in three parts: documentation, spatial map-based data, and printable map graphics of the database. Documentation includes this file, which provides a discussion of the surficial geology and describes the format and content of the map data, a database 'readme' file, which describes the database contents, and FGDC metadata for the spatial map information. Spatial data are distributed as Arc/Info coverage in ESRI interchange (e00) format, or as tabular data in the form of DBF3-file (.DBF) file formats. Map graphics files are distributed as Postscript and Adobe Portable Document Format (PDF) files, and are appropriate for representing a view of the spatial database at the mapped scale.

  10. Elucidation of structure and nature of the PdO-Pd transformation using in situ PDF and XAS techniques.

    PubMed

    Keating, Jonathan; Sankar, Gopinathan; Hyde, Timothy I; Kohara, Shinji; Ohara, Koji

    2013-06-14

    The PdO-Pd phase transformation in a 4 wt% Pd/Al2O3 catalyst has been investigated using in situ X-ray absorption spectroscopy (XAS) and in situ X-ray total scattering (also known as high-energy X-ray diffraction) techniques. Both the partial and total pair distribution functions (PDF) from these respective techniques have been analysed in depth. New information from PDF analysis of total scattering data has been garnered using the differential PDF (d-PDF) approach where only correlations orginating from PdO and metallic Pd are extracted. This method circumvents problems encountered in characerising the catalytically active components due to the diffuse scattering from the disordered γ-Al2O3 support phase. Quantitative analysis of the palladium components within the catalyst allowed for the phase composition to be established at various temperatures. Above 850 °C it was found that PdO had converted to metallic Pd, however, the extent of reduction was of the order ca. 70% Pd metal and 30% PdO. Complementary in situ XANES and EXAFS were performed, with heating to high temperature and subsequent cooling in air, and the results of the analyses support the observations, that residual PdO is detected at elevated temperatures. Hysteresis in the transformation upon cooling is confirmed from XAS studies where reoxidation occurs below 680 °C.

  11. Asymptotic stability of spectral-based PDF modeling for homogeneous turbulent flows

    NASA Astrophysics Data System (ADS)

    Campos, Alejandro; Duraisamy, Karthik; Iaccarino, Gianluca

    2015-11-01

    Engineering models of turbulence, based on one-point statistics, neglect spectral information inherent in a turbulence field. It is well known, however, that the evolution of turbulence is dictated by a complex interplay between the spectral modes of velocity. For example, for homogeneous turbulence, the pressure-rate-of-strain depends on the integrated energy spectrum weighted by components of the wave vectors. The Interacting Particle Representation Model (IPRM) (Kassinos & Reynolds, 1996) and the Velocity/Wave-Vector PDF model (Van Slooten & Pope, 1997) emulate spectral information in an attempt to improve the modeling of turbulence. We investigate the evolution and asymptotic stability of the IPRM using three different approaches. The first approach considers the Lagrangian evolution of individual realizations (idealized as particles) of the stochastic process defined by the IPRM. The second solves Lagrangian evolution equations for clusters of realizations conditional on a given wave vector. The third evolves the solution of the Eulerian conditional PDF corresponding to the aforementioned clusters. This last method avoids issues related to discrete particle noise and slow convergence associated with Lagrangian particle-based simulations.

  12. Potential utility of a peptide deformylase inhibitor (NVP PDF-713) against oxazolidinone-resistant or streptogramin-resistant Gram-positive organism isolates.

    PubMed

    Jones, Ronald N; Moet, Gary J; Sader, Helio S; Fritsche, Thomas R

    2004-05-01

    To evaluate the potency of a novel peptide deformylase inhibitor, NVP PDF-713, against Gram-positive organisms having resistances to linezolid or quinupristin/dalfopristin. A total of 45 strains from three genera (six species groups) were tested by reference broth microdilution methods. The mechanism of resistance to the oxazolidinone was determined by sequencing of the gene encoding the ribosomal target. NVP PDF-713 retained activity against linezolid-resistant staphylococci (MIC range 0.25-2 mg/L), Streptococcus oralis (MIC 0.5 mg/L), Enterococcus faecalis (MIC range 2-4 mg/L) and Enterococcus faecium (MIC range 0.5-4 mg/L). Quinupristin/dalfopristin-resistant E. faecium (MIC range 1-2 mg/L) and staphylococci (MIC range 0.12-2 mg/L) were also inhibited by NVP PDF-713. Many (10 of 13 strains) of the linezolid-resistant enterococci were resistant to vancomycin and these clinical strains had a G2576U ribosomal target mutation. NVP PDF-713 appears to be a promising clinical candidate among the peptide deformylase inhibitors for the treatment of infections caused by Gram-positive organisms that possess resistances to oxazolidinones or streptogramin combinations.

  13. The photon PDF from high-mass Drell-Yan data at the LHC.

    PubMed

    Giuli, F

    2017-01-01

    Achieving the highest precision for theoretical predictions at the LHC requires the calculation of hard-scattering cross sections that include perturbative QCD corrections up to (N)NNLO and electroweak (EW) corrections up to NLO. Parton distribution functions (PDFs) need to be provided with matching accuracy, which in the case of QED effects involves introducing the photon parton distribution of the proton, [Formula: see text]. In this work a determination of the photon PDF from fits to recent ATLAS measurements of high-mass Drell-Yan dilepton production at [Formula: see text] TeV is presented. This analysis is based on the xFitter framework, and has required improvements both in the APFEL program, to account for NLO QED effects, and in the aMCfast interface to account for the photon-initiated contributions in the EW calculations within MadGraph5_aMC@NLO. The results are compared with other recent QED fits and determinations of the photon PDF, consistent results are found.

  14. 76 FR 23222 - Electric Reliability Organization Interpretation of Transmission Operations Reliability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... applications or print-to-PDF format, and not in a scanned format, at http://www.ferc.gov/docs-filing/efiling....3d 1342 (DC Cir. 2009). \\5\\ Mandatory Reliability Standards for the Bulk-Power System, Order No. 693... applications or print-to-PDF format and not in a scanned format. Commenters filing electronically do not need...

  15. 78 FR 30245 - Electric Reliability Organization Interpretation of Specific Requirements of the Disturbance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... print-to-PDF format and not in a scanned format. Mail/Hand Delivery: Commenters unable to file comments.... FERC, 564 F.3d 1342 (DC Cir. 2009). 3. In March 2007, the Commission issued Order No. 693, evaluating... should be filed in native applications or print-to-PDF format and not in a scanned format. Commenters...

  16. Refinement of the Pion PDF implementing Drell-Yan and Deep Inelastic Scattering Experimental Data

    NASA Astrophysics Data System (ADS)

    Barry, Patrick; Sato, Nobuo; Melnitchouk, Wally; Ji, Chueng-Ryong

    2017-09-01

    We realize that an abundance of ``sea'' quarks and gluons (as opposed to three valence quarks) is crucial to understanding the mass and internal structure of the proton. An effective pion cloud exists around the core valence structure. In the Drell-Yan (DY) process, two hadrons collide, one donating a quark and the other donating an antiquark. The quark-antiquark pair annihilate, forming a virtual photon, which creates a lepton-antilepton pair. By measuring their cross-sections, we obtain information about the parton distribution function (PDF) of the hadrons. The PDF is the probability of finding a parton at a momentum fraction of the hadron, x, between 0 and 1. Complementary to the DY process is deep inelastic scattering (DIS). Here, a target nucleon is probed by a lepton, and we investigate the pion cloud of the nucleon. The experiments H1 and ZEUS done at HERA at DESY collect DIS data by detecting a leading neutron (LN). By using nested sampling to generate sets of parameters, we present some preliminary fits of pion PDFs to DY (Fermilab-E615 and CERN-NA10) and LN (H1 and ZEUS) datasets. We aim to perform a full NLO QCD global analysis to determine pion PDFs accurately for all x. There have been no attempts to fit the pion PDF using both low and high x data until now.

  17. The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion

    PubMed Central

    Chen, Didi; Taylor, Kelsey P.; Hall, Qi; Kaplan, Joshua M.

    2016-01-01

    During larval molts, Caenorhabditis elegans exhibits a sleep-like state (termed lethargus) that is characterized by the absence of feeding and profound locomotion quiescence. The rhythmic pattern of locomotion quiescence and arousal linked to the molting cycle is mediated by reciprocal changes in sensory responsiveness, whereby arousal is associated with increased responsiveness. Sensory neurons arouse locomotion via release of a neuropeptide (PDF-1) and glutamate. Here we identify a second arousing neuropeptide (FLP-2). We show that FLP-2 acts via an orexin-like receptor (FRPR-18), and that FLP-2 and PDF-1 secretion are regulated by reciprocal positive feedback. These results suggest that the aroused behavioral state is stabilized by positive feedback between two neuropeptides. PMID:27585848

  18. Timing of oil and gas generation of petroleum systems in the Southwestern Wyoming Province

    USGS Publications Warehouse

    Roberts, L.N.R.; Lewan, M.D.; Finn, T.M.

    2004-01-01

    Burial history, thermal maturity, and timing of petroleum generation were modeled for eight key source-rock horizons at seven locations throughout the Southwestern Wyoming Province. The horizons are the bases of the Lower Permian Phosphoria Formation, the Upper Cretaceous Mowry Shale, Niobrara Formation, Baxter Shale (and equivalents), upper part of the Mesaverde Group, Lewis Shale, Lance Formation, and the Tertiary (Paleocene) Fort Union Formation. Burial history locations include three in the deepest parts of the province (Adobe Town in the Washakie Basin, Eagles Nest in the Great Divide Basin, and Wagon Wheel in the northern Green River Basin); two at intermediate basin depths (Federal 31-1 and Currant, Creek in the central and southern parts of the Green River Basin, respectively); and two relatively shallow locations (Bear 1 on the southeastern margin of the Sand Wash Basin and Bruff 2 on the Moxa arch). An overall ranking of the burial history locations in order of decreasing thermal maturity is Adobe Town > Eagles Nest > Wagon Wheel > Currant Creek > Federal 31-1 > Bear-1 > Bruff 2. The results of the models indicate that peak petroleum generation from Cretaceous oil- and gas-prone source rocks in the deepest parts of the province occurred from Late Cretaceous through middle Eocene. At the modeled locations, peak oil generation from source rocks of the Phosphoria Formation, which contain type-IIS kerogen, occurred in the Late Cretaceous (80 to 73 million years ago (Ma)). Gas generation from the cracking of Phosphoria oil reached a peak in the late Paleocene (57 Ma) only in the deepest parts of the province. The Mowry Shale, Niobrara Formation, and Baxter Shale (and equivalents) contain type-IIS or a mix of type-II and type-III kerogens. Oil generation from these units, in the deepest parts of the province, reached peak rates during the latest Cretaceous to early Paleocene (66 to 61 Ma). Only at these deepest locations did these units reach peak gas

  19. Modeling the Bergeron-Findeisen Process Using PDF Methods With an Explicit Representation of Mixing

    NASA Astrophysics Data System (ADS)

    Jeffery, C.; Reisner, J.

    2005-12-01

    Currently, the accurate prediction of cloud droplet and ice crystal number concentration in cloud resolving, numerical weather prediction and climate models is a formidable challenge. The Bergeron-Findeisen process in which ice crystals grow by vapor deposition at the expense of super-cooled droplets is expected to be inhomogeneous in nature--some droplets will evaporate completely in centimeter-scale filaments of sub-saturated air during turbulent mixing while others remain unchanged [Baker et al., QJRMS, 1980]--and is unresolved at even cloud-resolving scales. Despite the large body of observational evidence in support of the inhomogeneous mixing process affecting cloud droplet number [most recently, Brenguier et al., JAS, 2000], it is poorly understood and has yet to be parameterized and incorporated into a numerical model. In this talk, we investigate the Bergeron-Findeisen process using a new approach based on simulations of the probability density function (PDF) of relative humidity during turbulent mixing. PDF methods offer a key advantage over Eulerian (spatial) models of cloud mixing and evaporation: the low probability (cm-scale) filaments of entrained air are explicitly resolved (in probability space) during the mixing event even though their spatial shape, size and location remain unknown. Our PDF approach reveals the following features of the inhomogeneous mixing process during the isobaric turbulent mixing of two parcels containing super-cooled water and ice, respectively: (1) The scavenging of super-cooled droplets is inhomogeneous in nature; some droplets evaporate completely at early times while others remain unchanged. (2) The degree of total droplet evaporation during the initial mixing period depends linearly on the mixing fractions of the two parcels and logarithmically on Damköhler number (Da)---the ratio of turbulent to evaporative time-scales. (3) Our simulations predict that the PDF of Lagrangian (time-integrated) subsaturation (S) goes as

  20. Publications - PDF 95-33C | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 95-33C Publication Details Title: Surficial geologic map of the Charley River D-1, C-1 , and part of the B-1 quadrangles, east-central Alaska Authors: Pinney, D.S., Clough, J.G., and Liss ., 1995, Surficial geologic map of the Charley River D-1, C-1, and part of the B-1 quadrangles, east

  1. AsteriX: a Web server to automatically extract ligand coordinates from figures in PDF articles.

    PubMed

    Lounnas, V; Vriend, G

    2012-02-27

    Coordinates describing the chemical structures of small molecules that are potential ligands for pharmaceutical targets are used at many stages of the drug design process. The coordinates of the vast majority of ligands can be obtained from either publicly accessible or commercial databases. However, interesting ligands sometimes are only available from the scientific literature, in which case their coordinates need to be reconstructed manually--a process that consists of a series of time-consuming steps. We present a Web server that helps reconstruct the three-dimensional (3D) coordinates of ligands for which a two-dimensional (2D) picture is available in a PDF file. The software, called AsteriX, analyses every picture contained in the PDF file and attempts to determine automatically whether or not it contains ligands. Areas in pictures that may contain molecular structures are processed to extract connectivity and atom type information that allow coordinates to be subsequently reconstructed. The AsteriX Web server was tested on a series of articles containing a large diversity in graphical representations. In total, 88% of 3249 ligand structures present in the test set were identified as chemical diagrams. Of these, about half were interpreted correctly as 3D structures, and a further one-third required only minor manual corrections. It is principally impossible to always correctly reconstruct 3D coordinates from pictures because there are many different protocols for drawing a 2D image of a ligand, but more importantly a wide variety of semantic annotations are possible. The AsteriX Web server therefore includes facilities that allow the users to augment partial or partially correct 3D reconstructions. All 3D reconstructions are submitted, checked, and corrected by the users domain at the server and are freely available for everybody. The coordinates of the reconstructed ligands are made available in a series of formats commonly used in drug design research. The

  2. Drosophila DH31 Neuropeptide and PDF Receptor Regulate Night-Onset Temperature Preference

    PubMed Central

    Goda, Tadahiro; Tang, Xin; Umezaki, Yujiro; Chu, Michelle L.

    2016-01-01

    Body temperature exhibits rhythmic fluctuations over a 24 h period (Refinetti and Menaker, 1992) and decreases during the night, which is associated with sleep initiation (Gilbert et al., 2004; Kräuchi, 2007a,b). However, the underlying mechanism of this temperature decrease is largely unknown. We have previously shown that Drosophila exhibit a daily temperature preference rhythm (TPR), in which their preferred temperatures increase during the daytime and then decrease at the transition from day to night (night-onset) (Kaneko et al., 2012). Because Drosophila are small ectotherms, their body temperature is very close to that of the ambient temperature (Stevenson, 1985), suggesting that their TPR generates their body temperature rhythm. Here, we demonstrate that the neuropeptide diuretic hormone 31 (DH31) and pigment-dispersing factor receptor (PDFR) contribute to regulate the preferred temperature decrease at night-onset. We show that PDFR and tethered-DH31 expression in dorsal neurons 2 (DN2s) restore the preferred temperature decrease at night-onset, suggesting that DH31 acts on PDFR in DN2s. Notably, we previously showed that the molecular clock in DN2s is important for TPR. Although PDF (another ligand of PDFR) is a critical factor for locomotor activity rhythms, Pdf mutants exhibit normal preferred temperature decreases at night-onset. This suggests that DH31-PDFR signaling specifically regulates a preferred temperature decrease at night-onset. Thus, we propose that night-onset TPR and locomotor activity rhythms are differentially controlled not only by clock neurons but also by neuropeptide signaling in the brain. SIGNIFICANCE STATEMENT Body temperature rhythm (BTR) is fundamental for the maintenance of functions essential for homeostasis, such as generating metabolic energy and sleep. One major unsolved question is how body temperature decreases dramatically during the night. Previously, we demonstrated that a BTR-like mechanism, referred to as temperature

  3. Publications - PDF 93-47 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 93-47 Publication Details Title: Geologic map of the Sleetmute C-7, D-7, C-8, and D-8 ., Harris, E.E., Kline, J.T., and Miller, M.L., 1993, Geologic map of the Sleetmute C-7, D-7, C-8, and D-8 Sleetmute C-7, C-8, D-7 and D-8 quadrangles, Horn Mountain Area, southwest Alaska, scale 1:63,360 (34.0 M

  4. A Role for the GCC-Box in Jasmonate-Mediated Activation of the PDF1.2 Gene of Arabidopsis1

    PubMed Central

    Brown, Rebecca L.; Kazan, Kemal; McGrath, Ken C.; Maclean, Don J.; Manners, John M.

    2003-01-01

    The PDF1.2 gene of Arabidopsis encoding a plant defensin is commonly used as a marker for characterization of the jasmonate-dependent defense responses. Here, using PDF1.2 promoter-deletion lines linked to the β-glucoronidase-reporter gene, we examined putative promoter elements associated with jasmonate-responsive expression of this gene. Using stably transformed plants, we first characterized the extended promoter region that positively regulates basal expression from the PDF1.2 promoter. Second, using promoter deletion constructs including one from which the GCC-box region was deleted, we observed a substantially lower response to jasmonate than lines carrying this motif. In addition, point mutations introduced into the core GCC-box sequence substantially reduced jasmonate responsiveness, whereas addition of a 20-nucleotide-long promoter element carrying the core GCC-box and flanking nucleotides provided jasmonate responsiveness to a 35S minimal promoter. Taken together, these results indicated that the GCC-box plays a key role in conferring jasmonate responsiveness to the PDF1.2 promoter. However, deletion or specific mutations introduced into the core GCC-box did not completely abolish the jasmonate responsiveness of the promoter, suggesting that the other promoter elements lying downstream from the GCC-box region may also contribute to jasmonate responsiveness. In other experiments, we identified a jasmonate- and pathogen-responsive ethylene response factor transcription factor, AtERF2, which when overexpressed in transgenic Arabidopsis plants activated transcription from the PDF1.2, Thi2.1, and PR4 (basic chitinase) genes, all of which contain a GCC-box sequence in their promoters. Our results suggest that in addition to their roles in regulating ethylene-mediated gene expression, ethylene response factors also appear to play important roles in regulating jasmonate-responsive gene expression, possibly via interaction with the GCC-box. PMID:12805630

  5. 78 FR 19152 - Revisions to Modeling, Data, and Analysis Reliability Standard

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... processing software should be filed in native applications or print-to-PDF format and not in a scanned format...,126 (2006), aff'd sub nom. Alcoa, Inc. v. FERC, 564 F.3d 1342 (D.C. Cir. 2009). 3. In March 2007, the... print-to-PDF format and not in a scanned format. Commenters filing electronically do not need to make a...

  6. 78 FR 38304 - Applications for New Awards; Native Hawaiian Career and Technical Education Program (NHCTEP...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... document published in the Federal Register. Free Internet access to the official edition of the Federal... Service (FRS), toll free, at 1- 800-877-8339. Accessible Format: Individuals with disabilities can obtain... Adobe Acrobat Reader, which is available free at the site. You may also access documents of the...

  7. The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.

    PubMed

    Chen, Didi; Taylor, Kelsey P; Hall, Qi; Kaplan, Joshua M

    2016-11-01

    During larval molts, Caenorhabditis elegans exhibits a sleep-like state (termed lethargus) that is characterized by the absence of feeding and profound locomotion quiescence. The rhythmic pattern of locomotion quiescence and arousal linked to the molting cycle is mediated by reciprocal changes in sensory responsiveness, whereby arousal is associated with increased responsiveness. Sensory neurons arouse locomotion via release of a neuropeptide (PDF-1) and glutamate. Here we identify a second arousing neuropeptide (FLP-2). We show that FLP-2 acts via an orexin-like receptor (FRPR-18), and that FLP-2 and PDF-1 secretion are regulated by reciprocal positive feedback. These results suggest that the aroused behavioral state is stabilized by positive feedback between two neuropeptides. Copyright © 2016 by the Genetics Society of America.

  8. Preliminary geologic map of the Perris 7.5' quadrangle, Riverside County, California

    USGS Publications Warehouse

    Morton, Douglas M.; Digital preparation by Bovard, Kelly R.; Alvarez, Rachel M.

    2003-01-01

    Open-File Report 03-270 contains a digital geologic map database of the Perris 7.5’ quadrangle, Riverside County, California that includes: 1. ARC/INFO (Environmental Systems Research Institute, http://www.esri.com) version 7.2.1 coverages of the various elements of the geologic map. 2. A Postscript file to plot the geologic map on a topographic base, and containing a Correlation of Map Units diagram (CMU), a Description of Map Units (DMU), and an index map. 3. Portable Document Format (.pdf) files of: a. A Readme file b. The same graphic as described in 2 above. Test plots have not produced precise 1:24,000- scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formationname, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc.

  9. Geologic map of the Lake Mathews 7.5' quadrangle, Riverside County, California

    USGS Publications Warehouse

    Morton, Douglas M.; Weber, F. Harold

    2001-01-01

    a. This Readme; includes in Appendix I, data contained in lkm_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Miscellaneous Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous.Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand.In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Marine deposits are in part overlain by local, mostly alluvial fan, deposits and are labeled Qomf. Grain size follows f. Even though this is an Open-File report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above).

  10. Geologic map of the Sunnymead 7.5' quadrangle, Riverside County, California

    USGS Publications Warehouse

    Morton, Douglas M.; Matti, Jonathan C.

    2001-01-01

    a. This Readme; includes in Appendix I, data contained in sun_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Marine deposits are in part overlain by local, mostly alluvial fan, deposits and are labeled Qomf. Grain size follows f. Even though this is an Open-File Report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above).

  11. Geologic map of the Steele Peak 7.5' quadrangle, Riverside County, California

    USGS Publications Warehouse

    Morton, Douglas M.; digital preparation by Alvarez, Rachel M.; Diep, Van M.

    2001-01-01

    a. This Readme; includes in Appendix I, data contained in stp_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Marine deposits are in part overlain by local, mostly alluvial fan, deposits and are labeled Qomf. Grain size follows f. Even though this is an Open-File Report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above).

  12. Geologic map of the Riverside West 7.5' quadrangle, Riverside County, California

    USGS Publications Warehouse

    Morton, Douglas M.; Cox, Brett F.

    2001-01-01

    a. This Readme; includes in Appendix I, data contained in rsw_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Marine deposits are in part overlain by local, mostly alluvial fan, deposits and are labeled Qomf. Grain size follows f.Even though this is an Open-File Report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above).

  13. Geologic map of the Riverside East 7.5' quadrangle, Riverside County, California

    USGS Publications Warehouse

    Morton, Douglas M.; Cox, Brett F.

    2001-01-01

    a. This Readme; includes in Appendix I, data contained in rse_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Marine deposits are in part overlain by local, mostly alluvial fan, deposits and are labeled Qomf. Grain size follows f. Even though this is an Open-File Report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above).

  14. Geologic map of the Corona North 7.5' quadrangle, Riverside and San Bernardino counties, California

    USGS Publications Warehouse

    Morton, Douglas M.; Gray, C.H.; Bovard, Kelly R.; Dawson, Michael

    2002-01-01

    a. This Readme; includes in Appendix I, data contained in crn_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced precise 1:24,000- scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Marine deposits are in part overlain by local, mostly alluvial fan, deposits and are labeled Qomf. Grain size follows f. Even though this is an Open-File Report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above).

  15. Geologic map of the Corona South 7.5' quadrangle, Riverside and Orange counties, California

    USGS Publications Warehouse

    Gray, C.H.; Morton, Douglas M.; Weber, F. Harold; Digital preparation by Bovard, Kelly R.; O'Brien, Timothy

    2002-01-01

    a. A Readme file; includes in Appendix I, data contained in crs_met.txt b. The same graphic as plotted in 2 above. Test plots have not produced 1:24,000-scale map sheets. Adobe Acrobat page size setting influences map scale. The Correlation of Map Units and Description of Map Units is in the editorial format of USGS Geologic Investigations Series (I-series) maps but has not been edited to comply with I-map standards. Within the geologic map data package, map units are identified by standard geologic map criteria such as formation-name, age, and lithology. Where known, grain size is indicated on the map by a subscripted letter or letters following the unit symbols as follows: lg, large boulders; b, boulder; g, gravel; a, arenaceous; s, silt; c, clay; e.g. Qyfa is a predominantly young alluvial fan deposit that is arenaceous. Multiple letters are used for more specific identification or for mixed units, e.g., Qfysa is a silty sand. In some cases, mixed units are indicated by a compound symbol; e.g., Qyf2sc. Marine deposits are in part overlain by local, mostly alluvial fan, deposits and are labeled Qomf. Grain size follows f. Even though this is an Open-File Report and includes the standard USGS Open-File disclaimer, the report closely adheres to the stratigraphic nomenclature of the U.S. Geological Survey. Descriptions of units can be obtained by viewing or plotting the .pdf file (3b above) or plotting the postscript file (2 above).

  16. Geologic Map and Cross Sections of the McGinness Hills Geothermal Area - GIS Data

    DOE Data Explorer

    Faulds, James E.

    2013-12-31

    Geologic map data in shapefile format that includes faults, unit contacts, unit polygons, attitudes of strata and faults, and surficial geothermal features. 5 cross‐sections in Adobe Illustrator format. Comprehensive catalogue of drill‐hole data in spreadsheet, shapefile, and Geosoft database formats. Includes XYZ locations of well heads, year drilled, type of well, operator, total depths, well path data (deviations), lithology logs, and temperature data. 3D model constructed with EarthVision using geologic map data, cross‐sections, drill‐hole data, and geophysics.

  17. Solutions in radiology services management: a literature review.

    PubMed

    Pereira, Aline Garcia; Vergara, Lizandra Garcia Lupi; Merino, Eugenio Andrés Díaz; Wagner, Adriano

    2015-01-01

    The present study was aimed at reviewing the literature to identify solutions for problems observed in radiology services. Basic, qualitative, exploratory literature review at Scopus and SciELO databases, utilizing the Mendeley and Illustrator CC Adobe softwares. In the databases, 565 papers - 120 out of them, pdf free - were identified. Problems observed in the radiology sector are related to procedures scheduling, humanization, lack of training, poor knowledge and use of management techniques, and interaction with users. The design management provides the services with interesting solutions such as Benchmarking, CRM, Lean Approach, ServiceBlueprinting, continued education, among others. Literature review is an important tool to identify problems and respective solutions. However, considering the small number of studies approaching management of radiology services, this is a great field of research for the development of deeper studies.

  18. Publications - PDF 95-33E | Alaska Division of Geological & Geophysical

    Science.gov Websites

    content DGGS PDF 95-33E Publication Details Title: Geologic hazards map of the Charley River D-1, C-1, and part of the B-1 quadrangles, east-central Alaska Authors: Pinney, D.S., Clough, J.G., Reifenstuhl, R.R ., Reifenstuhl, R.R., and Liss, S.A., 1995, Geologic hazards map of the Charley River D-1, C-1, and part of the B

  19. Chemically reacting supersonic flow calculation using an assumed PDF model

    NASA Technical Reports Server (NTRS)

    Farshchi, M.

    1990-01-01

    This work is motivated by the need to develop accurate models for chemically reacting compressible turbulent flow fields that are present in a typical supersonic combustion ramjet (SCRAMJET) engine. In this paper the development of a new assumed probability density function (PDF) reaction model for supersonic turbulent diffusion flames and its implementation into an efficient Navier-Stokes solver are discussed. The application of this model to a supersonic hydrogen-air flame will be considered.

  20. The photon PDF from high-mass Drell–Yan data at the LHC

    DOE PAGES

    Giuli, F.

    2017-06-15

    Achieving the highest precision for theoretical predictions at the LHC requires the calculation of hard-scattering cross sections that include perturbative QCD corrections up to (N)NNLO and electroweak (EW) corrections up to NLO. Parton distribution functions (PDFs) need to be provided with matching accuracy, which in the case of QED effects involves introducing the photon parton distribution of the proton, xγ(x,Q2) . In this work a determination of the photon PDF from fits to recent ATLAS measurements of high-mass Drell–Yan dilepton production atmore » $$\\sqrt{s}$$=8 TeV is presented. This analysis is based on the xFitter framework, and has required improvements both in the APFEL program, to account for NLO QED effects, and in the aMCfast interface to account for the photon-initiated contributions in the EW calculations within MadGraph5_aMC@NLO. The results are compared with other recent QED fits and determinations of the photon PDF, consistent results are found.« less

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