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Sample records for adopt chair conformations

  1. EBV latency types adopt alternative chromatin conformations.

    PubMed

    Tempera, Italo; Klichinsky, Michael; Lieberman, Paul M

    2011-07-01

    Epstein-Barr Virus (EBV) can establish latent infections with distinct gene expression patterns referred to as latency types. These different latency types are epigenetically stable and correspond to different promoter utilization. Here we explore the three-dimensional conformations of the EBV genome in different latency types. We employed Chromosome Conformation Capture (3C) assay to investigate chromatin loop formation between the OriP enhancer and the promoters that determine type I (Qp) or type III (Cp) gene expression. We show that OriP is in close physical proximity to Qp in type I latency, and to Cp in type III latency. The cellular chromatin insulator and boundary factor CTCF was implicated in EBV chromatin loop formation. Combining 3C and ChIP assays we found that CTCF is physically associated with OriP-Qp loop formation in type I and OriP-Cp loop formation in type III latency. Mutations in the CTCF binding site located at Qp disrupt loop formation between Qp and OriP, and lead to the activation of Cp transcription. Mutation of the CTCF binding site at Cp, as well as siRNA depletion of CTCF eliminates both OriP-associated loops, indicating that CTCF plays an integral role in loop formation. These data indicate that epigenetically stable EBV latency types adopt distinct chromatin architectures that depend on CTCF and mediate alternative promoter targeting by the OriP enhancer. PMID:21829357

  2. Pseudorotational landscape of seven-membered rings: the most stable chair and twist-boat conformers of ε-caprolactone.

    PubMed

    Jahn, Michaela K; Dewald, David A; Vallejo-López, Montserrat; Cocinero, Emilio J; Lesarri, Alberto; Zou, Wenli; Cremer, Dieter; Grabow, Jens-Uwe

    2014-10-20

    The conformational landscape and ring-puckering properties of ε-caprolactone have been analyzed by using microwave spectroscopy and quantum chemical calculations. Two conformers were detected in a supersonic jet expansion, the most stable form being a chair containing the ester group in its rectangular flap. This conformation benefits from reduced CH2 bond eclipsing and angle strain, while π-electron delocalization in the ester group is increased. The derived effective structure of the chair form satisfactorily agrees with the calculated near-equilibrium structure. A twist-boat conformer was also identified (9.4 kJ mol(-1) higher in energy at CCSD(T)/aug-cc-pVTZ level), and was located in the boat-twist-boat pseudorotation cycle of the seven-membered ring. Three other low-energy conformers were investigated and characterized in terms of the four puckering coordinates of the seven-membered ring. Potential interconversions in the four-dimensional conformation space are also discussed. PMID:25196306

  3. The six-membered ring chair conformation of butane-1,3-diol in the gas phase

    NASA Astrophysics Data System (ADS)

    Caminati, Walther; Corbelli, Giorgio

    1982-02-01

    Only one conformer of butane-1,3-diol is detectable by conventional microwave spectroscopy. Analysis of the CH 2OHCH 2CHOHMe and CH 2ODCH 2CHODMe isotopic species has allowed the determination of this conformation as a hydrogen-chelated six-membered ring in a distorted chair configuration. The hydrogen atom in position 1 is the proton donor; the methyl group is trans to the C 1-C 2 bond and the hydroxyl hydrogen in position 3 is trans to the C 2-C 3 bond.

  4. Reversible chair ↔ skew conformational interconversion of 1,3,2-dioxaphosphorinane ring in the solid state.

    PubMed

    Řlepokura, Katarzyna Anna

    2016-02-01

    β-NH4[(MeO)2cDHAP] (where cDHAP is cyclic dihydroxyacetone phosphate) has been investigated by X-ray crystallography in the temperature range 350-100 K. Three reversible single-crystal-to-single-crystal phase transitions have been examined and four phases (high-, room-, medium- and low-temperature phase, HTP, RTP, MTP and LTP, respectively) have been structurally determined: HTP (at 350 K, P2(1)/a, Z = 24), RTP (290 K, P1, Z = 12), MTP (205 K, P2(1)/a, Z = 4) and LTP (100 K, P1, Z = 24). Various puckering modes of the 1,3,2-dioxaphosphorinane ring of the organic cyclic phosphate anion have been revealed in the crystal: chair and skew. The chair ↔ skew ring flipping, which has been shown to take place during the phase transitions, results in various populations of skew and chair conformers in different phases. The flexibility in the coordination geometry of ammonium cations is considered to assist in the conformational flexibility of the dioxaphosphorinane ring. PMID:26830803

  5. Interactome Analysis Reveals Ezrin Can Adopt Multiple Conformational States*

    PubMed Central

    Viswanatha, Raghuvir; Wayt, Jessica; Ohouo, Patrice Y.; Smolka, Marcus B.; Bretscher, Anthony

    2013-01-01

    Ezrin, a member of the ezrin-radixin-moesin family (ERM), is an essential regulator of the structure of microvilli on the apical aspect of epithelial cells. Ezrin provides a linkage between membrane-associated proteins and F-actin, oscillating between active/open and inactive/closed states, and is regulated in part by phosphorylation of a C-terminal threonine. In the open state, ezrin can bind a number of ligands, but in the closed state the ligand-binding sites are inaccessible. In vitro analysis has proposed that there may be a third hyperactivated form of ezrin. To gain a better understanding of ezrin, we conducted an unbiased proteomic analysis of ezrin-binding proteins in an epithelial cell line, Jeg-3. We refined our list of interactors by comparing the interactomes using quantitative mass spectrometry between wild-type ezrin, closed ezrin, open ezrin, and hyperactivated ezrin. The analysis reveals several novel interactors confirmed by their localization to microvilli, as well as a significant class of proteins that bind closed ezrin. Taken together, the data indicate that ezrin can exist in three different conformational states, and different ligands “perceive” ezrin conformational states differently. PMID:24151071

  6. Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations

    SciTech Connect

    Gokulan, Kuppan; Aggarwal, Anup; Shipman, Lance; Besra, Gurdyal S.; Sacchettini, James C.

    2011-07-01

    Bacterial acyl carrier protein synthase plays an essential role in the synthesis of fatty acids, nonribosomal peptides and polyketides. In Mycobacterium tuberculosis, AcpS or group I phosphopentatheine transferase exhibits two different structural conformations depending upon the pH. The crystal structures of acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis (Mtb) and Corynebacterium ammoniagenes determined at pH 5.3 and pH 6.5, respectively, are reported. Comparison of the Mtb apo-AcpS structure with the recently reported structure of the Mtb AcpS–ADP complex revealed that AcpS adopts two different conformations: the orthorhombic and trigonal space-group structures show structural differences in the α2 helix and in the conformation of the α3–α4 connecting loop, which is in a closed conformation. The apo-AcpS structure shows electron density for the entire model and was obtained at lower pH values (4.4–6.0). In contrast, at a higher pH value (6.5) AcpS undergoes significant conformational changes, resulting in disordered regions that show no electron density in the AcpS model. The solved structures also reveal that C. ammoniagenes AcpS undergoes structural rearrangement in two regions, similar to the recently reported Mtb AcpS–ADP complex structure. In vitro reconstitution experiments show that AcpS has a higher post-translational modification activity between pH 4.4 and 6.0 than at pH values above 6.5, where the activity drops owing to the change in conformation. The results show that apo-AcpS and AcpS–ADP adopt different conformations depending upon the pH conditions of the crystallization solution.

  7. Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations

    SciTech Connect

    Gokulan, Kuppan; Aggarwal, Anup; Shipman, Lance; Besra, Gurdyal S.; Sacchettini, James C.

    2011-09-20

    The crystal structures of acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis (Mtb) and Corynebacterium ammoniagenes determined at pH 5.3 and pH 6.5, respectively, are reported. Comparison of the Mtb apo-AcpS structure with the recently reported structure of the Mtb AcpS-ADP complex revealed that AcpS adopts two different conformations: the orthorhombic and trigonal space-group structures show structural differences in the {alpha}2 helix and in the conformation of the {alpha}3-{alpha}4 connecting loop, which is in a closed conformation. The apo-AcpS structure shows electron density for the entire model and was obtained at lower pH values (4.4-6.0). In contrast, at a higher pH value (6.5) AcpS undergoes significant conformational changes, resulting in disordered regions that show no electron density in the AcpS model. The solved structures also reveal that C. ammoniagenes AcpS undergoes structural rearrangement in two regions, similar to the recently reported Mtb AcpS-ADP complex structure. In vitro reconstitution experiments show that AcpS has a higher post-translational modification activity between pH 4.4 and 6.0 than at pH values above 6.5, where the activity drops owing to the change in conformation. The results show that apo-AcpS and AcpS-ADP adopt different conformations depending upon the pH conditions of the crystallization solution.

  8. Folding chair

    DOEpatents

    Cornell, Howell N.

    1985-08-20

    A foldable chair of the lawn chair type has ground-engaging front and rear legs, attached to and carrying a back frame and seat frame, the back frame and seat frame being pivotally attached to a spreader rod which extends beyond the back and seat frames to bear against one of the leg members when the chair is unfolded. A contact pad mounted on the extending portion of the spreader rod is formed as an externally-contoured bushing fit over the spreader rod and adapted to engage the leg member to restrict side-to-side movement of the spreader rod, with respect to the leg member, when the chair is unfolded.

  9. Calmodulin Adopts an Extended Conformation when Interacting with L-Selectin in Membranes

    PubMed Central

    Deng, Wei; Putkey, John A.; Li, Renhao

    2013-01-01

    Calmodulin, an intracellular calcium-binding protein, is thought to regulate ectodomain shedding of many membrane proteins, but the underlying molecular mechanism has remained unclear. Basing on a solution structure of calcium-loaded calmodulin in complex with a L-selectin fragment that contains a portion of its transmembrane domain, Gifford et al. (University of Calgary) recently suggested that calmodulin regulates L-selectin shedding by binding directly to a portion of the L-selectin transmembrane domain in a compact conformation. Using fluorescently labeled calmodulin, we show however that calmodulin adopts a distinctly different and much more extended conformation when it binds to the CLS peptide (i.e. the entire transmembrane and cytoplasmic domains of L-selectin) reconstituted in the phosphatidylcholine liposome with micromolar dissociation constant and in a calcium-independent manner. Calmodulin adopts a similarly extended conformation in a ternary complex with the N-terminal FERM domain of moesin and CLS reconstituted in the phospholipid liposome that mimics the native membrane environment. These results indicate that calmodulin does not bind directly to the transmembrane domain of L-selectin. Understanding the association of calmodulin with L-selectin helps to shed light on the mechanisms underlying regulation of ectodomain shedding. PMID:23658780

  10. The HAMP Signal Relay Domain Adopts Multiple Conformational States through Collective Piston and Tilt Motions

    PubMed Central

    Zhu, Lizhe; Bolhuis, Peter G.; Vreede, Jocelyne

    2013-01-01

    The HAMP domain is a linker region in prokaryotic sensor proteins and relays input signals to the transmitter domain and vice versa. Functional as a dimer, the structure of HAMP shows a parallel coiled-coil motif comprising four helices. To date, it is unclear how HAMP can relay signals from one domain to another, although several models exist. In this work, we use molecular simulation to test the hypothesis that HAMP adopts different conformations, one of which represents an active, signal-relaying configuration, and another an inactive, resting state. We first performed molecular dynamics simulation on the prototype HAMP domain Af1503 from Archaeoglobus fulgidus. We explored its conformational space by taking the structure of the A291F mutant disabling HAMP activity as a starting point. These simulations revealed additional conformational states that differ in the tilt angles between the helices as well as the relative piston shifts of the helices relative to each other. By enhancing the sampling in a metadynamics set up, we investigated three mechanistic models for HAMP signal transduction. Our results indicate that HAMP can access additional conformational states characterized by piston motion. Furthermore, the piston motion of the N-terminal helix of one monomer is directly correlated with the opposite piston motion of the C-terminal helix of the other monomer. The change in piston motion is accompanied by a change in tilt angle between the monomers, thus revealing that HAMP exhibits a collective motion, i.e. a combination of changes in tilt angles and a piston-like displacement. Our results provide insights into the conformational changes that underlie the signaling mechanism involving HAMP. PMID:23468603

  11. First Chair.

    ERIC Educational Resources Information Center

    Stewart, Donald C.

    1993-01-01

    A high school sophomore exceptionally talented on the violin is enraged and indignant when a less accomplished senior is given first chair in the school orchestra. After reacting rudely to the orchestra director and the principal, the girl discusses the situation with her supportive parents and resolves the problem. (JDD)

  12. Ergonomic Chairs

    NASA Technical Reports Server (NTRS)

    1997-01-01

    Findings published in the NASA Anthropometric Source Book by Johnson Space Center helped BodyBilt, Inc. to fashion controlled comfort chairs that lessen the harmful effects of gravity on seated workers. Crew members living aboard NASA's Skylab noted that in space the human posture differs from the normal posture caused by the tug of one gravity. There has been an alarming increase in back pain and muscle fatigue in workers, along with a dramatic escalation in repetitive stress injuries. BodyBilt's ergonomically-correct line of office chairs are targeted for the average worker that sits for prolonged periods, be it in the classroom or boardroom. Their roster of national clients lists such organizations as IBM, Microsoft, Texas Instruments, Hewlett-Packard, Eastman-Kodak, Boeing, Motorola, and Walt Disney Studios.

  13. Adoption

    MedlinePlus

    ... the birth nor adoptive parents know the others' identities. Other adoptions are handled more openly. Open adoptions, ... desire to seek out more information about the identity of the birth family. Most of us (whether ...

  14. Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration.

    PubMed

    Srinivasan, Sundaramoorthy; Cordomí, Arnau; Ramon, Eva; Garriga, Pere

    2016-03-01

    Human red and green visual pigments are seven transmembrane receptors of cone photoreceptor cells of the retina that mediate color vision. These pigments share a very high degree of homology and have been assumed to feature analogous structural and functional properties. We report on a different regeneration mechanism among red and green cone opsins with retinal analogs using UV-Vis/fluorescence spectroscopic analyses, molecular modeling and site-directed mutagenesis. We find that photoactivated green cone opsin adopts a transient conformation which regenerates via an unprotonated Schiff base linkage with its natural chromophore, whereas red cone opsin forms a typical protonated Schiff base. The chromophore regeneration kinetics is consistent with a secondary retinal uptake by the cone pigments. Overall, our findings reveal, for the first time, structural differences in the photoactivated conformation between red and green cone pigments that may be linked to their molecular evolution, and support the proposal of secondary retinal binding to visual pigments, in addition to binding to the canonical primary site, which may serve as a regulatory mechanism of dark adaptation in the phototransduction process. PMID:26387074

  15. Affinity-Tagged Miniprion Derivatives Spontaneously Adopt Protease-Resistant Conformations

    PubMed Central

    Supattapone, Surachai; Nguyen, Hoang-Oanh B.; Muramoto, Tamaki; Cohen, Fred E.; DeArmond, Stephen J.; Prusiner, Stanley B.; Scott, Michael

    2000-01-01

    An abridged PrP molecule of 106 amino acids designated PrP106 can form infectious miniprions in transgenic (Tg) mice (29). Addition of six-histidine (His6) affinity tags to selective sites within PrP106 resulted unexpectedly in new PrP proteins that spontaneously adopted protease-resistant conformations when expressed in neuroblastoma cells and Tg mice. Acquisition of protease resistance depended on the length, charge, and placement of the affinity tag. Introduction of the disease-linked mutation E200K into the sequence of PrP106(140/6His) increased the recovery of protease-resistant PrP fivefold, whereas introduction of the mutations C213A and Δ214–220 did not affect the recovery of protease-resistant PrP. Treatment of cultured cells expressing affinity-tagged PrP106 mutants with polypropyleneimine dendrimer rendered these proteins sensitive to protease digestion in a manner similar to wild-type PrPSc. We conclude that certain affinity-tagged PrP106 proteins spontaneously fold into conformations partially resembling, yet distinct from, wild-type PrPSc. These proteins might be useful tools in the identification of new disease-causing mutations as well as for screening compounds for therapeutic efficacy. PMID:11090193

  16. [Adoption].

    ERIC Educational Resources Information Center

    Pawl, Jeree, Ed.; And Others

    1990-01-01

    This newsletter theme issue addresses adoption and the young child's life. Contributors suggest ways in which practitioners in many professions and settings can better understand and support adoptive families. The first article, "Adoption, 1990" by Barbara F. Nordhaus and Albert J. Solnit, reviews the history of adoption and notes obstacles to…

  17. Conformations and Conformational Processes of Hexahydrobenzazocines by NMR and DFT Studies.

    PubMed

    Musielak, Bogdan; Holak, Tad A; Rys, Barbara

    2015-09-18

    Conformational processes that occur in hexahydrobenzazocines have been studied with the (1)H and (13)C dynamic nuclear magnetic resonance (DNMR) spectroscopy. The coalescence effects are assigned to two different conformational processes: the ring-inversion of the ground-state conformations and the interconversion between two different conformers. The barriers for these processes are in the range of 42-52 and 42-43 kJ mol(-1), respectively. Molecular modeling on the density functional theory (DFT) level and the gauge invariant atomic orbitals (GIAO)-DFT calculations of isotropic shieldings and coupling constants for the set of low-energy conformations were compared with the experimental NMR data. The ground-state of all compounds in solution is the boat-chair (BC) conformation. The BC form adopts two different conformations because the nitrogen atom can be in the boat or chair parts of the BC structure. These two conformers are engaged in the interconversion process. PMID:26317238

  18. Structural basis for the varying propensities of different amino acids to adopt the collagen conformation.

    PubMed

    Raman, S Sundar; Gopalakrishnan, R; Wade, R C; Subramanian, V

    2011-03-24

    Although previous experimental studies have shown the positional preference of different amino acids (AAs) to form a stable triple helical collagen motif, the structural basis for the variations in the sequence and the positional propensity has not been systematically investigated. Thus, we have here probed the origin of the structural stability offered by the 20 naturally occurring AAs to collagen by means of classical molecular dynamics (MD) simulation. Simulations were carried out on 39 collagen-like peptides employing a host-guest approach. The results show that the propensity of the different AAs to adopt collagen-like conformations depends primarily on their ϕ and ψ angle preferences. Changes in these angles upon substitution of different AAs in the X(AA) and Y(AA) positions in the canonical ((Gly-X(AA)-Y(AA))(7))(3) motif dictate the formation of interchain hydrogen bonds, solvent interactions, and puckering of neighboring imino acids and, thus, the structural stability of the collagen. The role of solvent-mediated hydrogen bonds in the stabilization of collagen has also been elucidated from the MD simulations. In addition to the conventional hydrogen bonds known to be present in collagen, a hitherto unidentified direct interchain hydrogen bond, between the X(AA) N-H group and the Hyp O-H group of the neighboring chain, was observed during the simulations. Its occupancy was ∼36% when Leu was present at the X(AA) position. PMID:21361324

  19. Radiation Pattern of Chair Armed Microstrip Antenna

    NASA Astrophysics Data System (ADS)

    Mishra, Rabindra Kishore; Sahu, Kumar Satyabrat

    2016-07-01

    This work analyzes planar antenna conformable to chair arm shaped surfaces for WLAN application. Closed form expressions for its radiation pattern are developed and validated using measurements on prototype and commercial EM code at 2.4 GHz.

  20. T Cell Receptor Engagement Triggers Its CD3ε and CD3ζ Subunits to Adopt a Compact, Locked Conformation

    PubMed Central

    Risueño, Ruth M.; Schamel, Wolfgang W. A.; Alarcón, Balbino

    2008-01-01

    How the T cell antigen receptor (TCR) discriminates between molecularly related peptide/Major Histocompatibility Complex (pMHC) ligands and converts this information into different possible signaling outcomes is still not understood. One current model proposes that strong pMHC ligands, but not weak ones, induce a conformational change in the TCR. Evidence supporting this comes from a pull-down assay that detects ligand-induced binding of the TCR to the N-terminal SH3 domain of the adapter protein Nck, and also from studies with a neoepitope-specific antibody. Both methods rely on the exposure of a polyproline sequence in the CD3ε subunit of the TCR, and neither indicates whether the conformational change is transmitted to other CD3 subunits. Using a protease-sensitivity assay, we now show that the cytoplasmic tails of CD3ε and CD3ζ subunits become fully protected from degradation upon TCR triggering. These results suggest that the TCR conformational change is transmitted to the tails of CD3ε and CD3ζ, and perhaps all CD3 subunits. Furthermore, the resistance to protease digestion suggests that CD3 cytoplasmic tails adopt a compact structure in the triggered TCR. These results are consistent with a model in which transduction of the conformational change induced upon TCR triggering promotes condensation and shielding of the CD3 cytoplasmic tails. PMID:18320063

  1. Premutation huntingtin allele adopts a non-B conformation and contains a hot spot for DNA damage

    SciTech Connect

    Jarem, Daniel A.; Delaney, Sarah

    2011-12-09

    Highlights: Black-Right-Pointing-Pointer First structural and thermodynamic analysis of premutation allele of HD. Black-Right-Pointing-Pointer Premutation allele of HD adopts a stem-loop non-B conformation. Black-Right-Pointing-Pointer Healthy and premutation length stem-loops are hyper-susceptible to oxidative damage. Black-Right-Pointing-Pointer Stability of stem-loop structures increases linearly with repeat length. Black-Right-Pointing-Pointer Thermodynamic stability, not the ability to adopt non-B conformation, distinguishes DNA prone to expansion from stable DNA. -- Abstract: The expansion of a CAG trinucleotide repeat (TNR) sequence has been linked to several neurological disorders, for example, Huntington's disease (HD). In HD, healthy individuals have 5-35 CAG repeats. Those with 36-39 repeats have the premutation allele, which is known to be prone to expansion. In the disease state, greater than 40 repeats are present. Interestingly, the formation of non-B DNA conformations by the TNR sequence is proposed to contribute to the expansion. Here we provide the first structural and thermodynamic analysis of a premutation length TNR sequence. Using chemical probes of nucleobase accessibility, we found that similar to (CAG){sub 10}, the premutation length sequence (CAG){sub 36} forms a stem-loop hairpin and contains a hot spot for DNA damage. Additionally, calorimetric analysis of a series of (CAG){sub n} sequences, that includes repeat tracts in both the healthy and premutation ranges, reveal that thermodynamic stability increases linearly with the number of repeats. Based on these data, we propose that while non-B conformations can be formed by TNR tracts found in both the healthy and premutation allele, only sequences containing at least 36 repeats have sufficient thermodynamic stability to contribute to expansion.

  2. E-selectin ligand complexes adopt an extended high-affinity conformation

    PubMed Central

    Preston, Roland C.; Jakob, Roman P.; Binder, Florian P.C.; Sager, Christoph P.; Ernst, Beat; Maier, Timm

    2016-01-01

    E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewisx (sLex). Efficient leukocyte recruitment under vascular flow conditions depends on an increased lifetime of E-selectin/ligand complexes under tensile force in a so-called catch-bond binding mode. Co-crystal structures of a representative fragment of the extracellular E-selectin region with sLex and a glycomimetic antagonist thereof reveal an extended E-selectin conformation, which is identified as a high-affinity binding state of E-selectin by molecular dynamics simulations. Small-angle X-ray scattering experiments demonstrate a direct link between ligand binding and E-selectin conformational transition under static conditions in solution. This permits tracing a series of concerted structural changes connecting ligand binding to conformational stretching as the structural basis of E-selectin catch-bond-mediated leukocyte recruitment. The detailed molecular view of the binding site paves the way for the design of a new generation of selectin antagonists. This is of special interest, since their therapeutic potential was recently demonstrated with the pan-selectin antagonists GMI-1070 (Rivipansel). PMID:26117840

  3. Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition

    PubMed Central

    Liu, Zhu; Gong, Zhou; Jiang, Wen-Xue; Yang, Ju; Zhu, Wen-Kai; Guo, Da-Chuan; Zhang, Wei-Ping; Liu, Mai-Li; Tang, Chun

    2015-01-01

    A polyubiquitin comprises multiple covalently linked ubiquitins and recognizes myriad targets. Free or bound to ligands, polyubiquitins are found in different arrangements of ubiquitin subunits. To understand the structural basis for polyubiquitin quaternary plasticity and to explore the target recognition mechanism, we characterize the conformational space of Lys63-linked diubiquitin (K63-Ub2). Refining against inter-subunit paramagnetic NMR data, we show that free K63-Ub2 exists as a dynamic ensemble comprising multiple closed and open quaternary states. The quaternary dynamics enables K63-Ub2 to be specifically recognized in a variety of signaling pathways. When binding to a target protein, one of the preexisting quaternary states is selected and stabilized. A point mutation that shifts the equilibrium between the different states modulates the binding affinities towards K63-Ub2 ligands. This conformational selection mechanism at the quaternary level may be used by polyubiquitins of different lengths and linkages for target recognition. DOI: http://dx.doi.org/10.7554/eLife.05767.001 PMID:26090905

  4. c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution

    PubMed Central

    2016-01-01

    Protein tyrosine kinases of the Abl family have diverse roles in normal cellular regulation and drive several forms of leukemia as oncogenic fusion proteins. In the crystal structure of the inactive c-Abl kinase core, the SH2 and SH3 domains dock onto the back of the kinase domain, resulting in a compact, assembled state. This inactive conformation is stabilized by the interaction of the myristoylated N-cap with a pocket in the C-lobe of the kinase domain. Mutations that perturb these intramolecular interactions result in kinase activation. Here, we present X-ray scattering solution structures of multidomain c-Abl kinase core proteins modeling diverse active states. Surprisingly, the relative positions of the regulatory N-cap, SH3, and SH2 domains in an active myristic acid binding pocket mutant (A356N) were virtually identical to those of the assembled wild-type kinase core, indicating that Abl kinase activation does not require dramatic reorganization of the downregulated core structure. In contrast, the positions of the SH2 and SH3 domains in a clinically relevant imatinib-resistant gatekeeper mutant (T315I) appear to be reconfigured relative to their positions in the wild-type protein. Our results demonstrate that c-Abl kinase activation can occur either with (T315I) or without (A356N) global allosteric changes in the core, revealing the potential for previously unrecognized signaling diversity. PMID:27166638

  5. A wireless ballistocardiographic chair.

    PubMed

    Junnila, Sakari; Akhbardeh, Alireza; Barna, Laurentiu C; Defee, Irek; Varri, Alpo

    2006-01-01

    This paper presents a wireless ballistocardiographic chair developed for the Proactive Health Monitoring project in the Institute of Signal Processing. EMFi sensors are used for BCG measurement and IEEE 802.15.4 RF link for radio communication between the chair and a PC. The chair measures two BCG signals from the seat and the backrest and a rough ECG signal from the armrests of the chair. The R-spike of the ECG signal can be used as a synchronisation point to extract individual BCG cardiac cycles. Also, two developed methods for extracting BCG cycles without using a reference ECG signal are presented and compared. PMID:17946348

  6. An Ergonomic Chair?

    MedlinePlus

    ... Ergonomic Chair? Food Safety Industrial Hygiene Integrated Pest Management OSHA 300A Summaries Public Access Defibrillation Program Drinking Water Safety Workplace Injury and Illness Trend Analysis Surveys ...

  7. The hexameric helicase DnaB adopts a nonplanar conformation during translocation.

    PubMed

    Itsathitphaisarn, Ornchuma; Wing, Richard A; Eliason, William K; Wang, Jimin; Steitz, Thomas A

    2012-10-12

    DNA polymerases can only synthesize nascent DNA from single-stranded DNA (ssDNA) templates. In bacteria, the unwinding of parental duplex DNA is carried out by the replicative DNA helicase (DnaB) that couples NTP hydrolysis to 5' to 3' translocation. The crystal structure of the DnaB hexamer in complex with GDP-AlF(4) and ssDNA reported here reveals that DnaB adopts a closed spiral staircase quaternary structure around an A-form ssDNA with each C-terminal domain coordinating two nucleotides of ssDNA. The structure not only provides structural insights into the translocation mechanism of superfamily IV helicases but also suggests that members of this superfamily employ a translocation mechanism that is distinct from other helicase superfamilies. We propose a hand-over-hand mechanism in which sequential hydrolysis of NTP causes a sequential 5' to 3' movement of the subunits along the helical axis of the staircase, resulting in the unwinding of two nucleotides per subunit. PMID:23022319

  8. Exhaustive Metropolis Monte Carlo sampling and analysis of polyalanine conformations adopted under the influence of hydrogen bonds.

    PubMed

    Podtelezhnikov, Alexei A; Wild, David L

    2005-10-01

    We propose a novel Metropolis Monte Carlo procedure for protein modeling and analyze the influence of hydrogen bonding on the distribution of polyalanine conformations. We use an atomistic model of the polyalanine chain with rigid and planar polypeptide bonds, and elastic alpha carbon valence geometry. We adopt a simplified energy function in which only hard-sphere repulsion and hydrogen bonding interactions between the atoms are considered. Our Metropolis Monte Carlo procedure utilizes local crankshaft moves and is combined with parallel tempering to exhaustively sample the conformations of 16-mer polyalanine. We confirm that Flory's isolated-pair hypothesis (the steric independence between the dihedral angles of individual amino acids) does not hold true in long polypeptide chains. In addition to 3(10)- and alpha-helices, we identify a kink stabilized by 2 hydrogen bonds with a shared acceptor as a common structural motif. Varying the strength of hydrogen bonds, we induce the helix-coil transition in the model polypeptide chain. We compare the propensities for various hydrogen bonding patterns and determine the degree of cooperativity of hydrogen bond formation in terms of the Hill coefficient. The observed helix-coil transition is also quantified according to Zimm-Bragg theory. PMID:16049911

  9. The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis.

    PubMed

    Arenz, Stefan; Abdelshahid, Maha; Sohmen, Daniel; Payoe, Roshani; Starosta, Agata L; Berninghausen, Otto; Hauryliuk, Vasili; Beckmann, Roland; Wilson, Daniel N

    2016-07-27

    Under stress conditions, such as nutrient starvation, deacylated tRNAs bound within the ribosomal A-site are recognized by the stringent factor RelA, which converts ATP and GTP/GDP to (p)ppGpp. The signaling molecules (p)ppGpp globally rewire the cellular transcriptional program and general metabolism, leading to stress adaptation. Despite the additional importance of the stringent response for regulation of bacterial virulence, antibiotic resistance and persistence, structural insight into how the ribosome and deacylated-tRNA stimulate RelA-mediated (p)ppGpp has been lacking. Here, we present a cryo-EM structure of RelA in complex with the Escherichia coli 70S ribosome with an average resolution of 3.7 Å and local resolution of 4 to >10 Å for RelA. The structure reveals that RelA adopts a unique 'open' conformation, where the C-terminal domain (CTD) is intertwined around an A/T-like tRNA within the intersubunit cavity of the ribosome and the N-terminal domain (NTD) extends into the solvent. We propose that the open conformation of RelA on the ribosome relieves the autoinhibitory effect of the CTD on the NTD, thus leading to stimulation of (p)ppGpp synthesis by RelA. PMID:27226493

  10. The Supportive Chair.

    ERIC Educational Resources Information Center

    Rosbottom, Ronald C.

    1987-01-01

    Recommendations for chairs of college-level foreign language departments include: being supportive of the department; communicating fully and openly with faculty and staff; promoting grantsmanship; and encouraging staff and faculty. Recommendations for deans working with chairs and department heads include: consulting frequently and communicating…

  11. About Department Chairs.

    ERIC Educational Resources Information Center

    Bennett, John B.

    1989-01-01

    Department chairs occupy what is arguably one of the most important administrative spots in a higher education institution. As a group, they set the academic tone of the institution and greatly facilitate or hinder the accomplishment of its mission. The various types of department chairs are described: hopeful, survivors, transient, and…

  12. 4 CFR 27.2 - The Chair, Vice Chair.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false The Chair, Vice Chair. 27.2 Section 27.2 Accounts GOVERNMENT ACCOUNTABILITY OFFICE GENERAL PROCEDURES GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL APPEALS BOARD; ORGANIZATION § 27.2 The Chair, Vice Chair. The members of the Board shall select from among its membership...

  13. Stress Reducing Chair

    NASA Technical Reports Server (NTRS)

    1992-01-01

    The Flogiston Chair incorporates NASA human factors in spacecraft design technology as well as information from NASA's Anthropometric Source Book. Designed by Brian V. Park, it provides a close approximation of the natural position a body assumes in weightless space. Its principal markets are information workers, designers, software developers, data processors, etc. It assists in maintaining concentration, is useful for relaxation and reality ventures. The chair may be fixed, rockable, or suspended from the ceiling.

  14. Chair-ish.

    ERIC Educational Resources Information Center

    Greenman, Geri

    2000-01-01

    Presents an art assignment that helps students progress from color theory and the color wheel to understanding watercolor techniques. Explains that students apply their knowledge of watercolor techniques by using three of ten techniques to create different views of a chair in the Cubist style. (CMK)

  15. Chairing a Small Department.

    ERIC Educational Resources Information Center

    Bowker, Lee H.; Lynch, David M.

    Ten management problems for chairs of small departments in small colleges are discussed, along with problem-solving strategies for these administrators. Serious disagreements within a small and intimate department may create a country club culture in which differences are smoothed over and the personal idiosyncrasies of individual members are…

  16. Resources Available to Department Chairs.

    ERIC Educational Resources Information Center

    Lynch, David M.; Bowker, Lee H.

    Resources available to department chairs from the following sources are described: the department's discipline; the national higher education community; the local institution; and the chair's own skills, background, roles, and structural placement within the organization. The use of these resources to deal with common problems faced by chairs is…

  17. A critical base pair in k-turns determines the conformational class adopted, and correlates with biological function.

    PubMed

    Huang, Lin; Wang, Jia; Lilley, David M J

    2016-06-20

    k-turns are commonly-occurring motifs that introduce sharp kinks into duplex RNA, thereby facilitating tertiary contacts. Both the folding and conformation of k-turns are determined by their local sequence. k-turns fall into two conformational classes, called N3 and N1, that differ in the pattern of hydrogen bonding in the core. We show here that this is determined by the basepair adjacent to the critical G•A pairs. We determined crystal structures of a series of Kt-7 variants in which this 3b,3n position has been systematically varied, showing that this leads to a switch in the conformation. We have previously shown that the 3b,3n position also determines the folding characteristics of the k-turn, i.e. whether or not the k-turn can fold in the presence of metal ions alone. We have analyzed the distribution of 3b,3n sequences from four classes of k-turns from ribosomes, riboswitches and U4 snRNA, finding a strong conservation of properties for a given k-turn type. We thus demonstrate a strong association between biological function, 3b,3n sequence and k-turn folding and conformation. This has strong predictive power, and can be applied to the modeling of large RNA architectures. PMID:27016741

  18. A critical base pair in k-turns determines the conformational class adopted, and correlates with biological function

    PubMed Central

    Huang, Lin; Wang, Jia; Lilley, David M. J.

    2016-01-01

    k-turns are commonly-occurring motifs that introduce sharp kinks into duplex RNA, thereby facilitating tertiary contacts. Both the folding and conformation of k-turns are determined by their local sequence. k-turns fall into two conformational classes, called N3 and N1, that differ in the pattern of hydrogen bonding in the core. We show here that this is determined by the basepair adjacent to the critical G•A pairs. We determined crystal structures of a series of Kt-7 variants in which this 3b,3n position has been systematically varied, showing that this leads to a switch in the conformation. We have previously shown that the 3b,3n position also determines the folding characteristics of the k-turn, i.e. whether or not the k-turn can fold in the presence of metal ions alone. We have analyzed the distribution of 3b,3n sequences from four classes of k-turns from ribosomes, riboswitches and U4 snRNA, finding a strong conservation of properties for a given k-turn type. We thus demonstrate a strong association between biological function, 3b,3n sequence and k-turn folding and conformation. This has strong predictive power, and can be applied to the modeling of large RNA architectures. PMID:27016741

  19. Post-Translational Phosphorylation of Serine 74 of Human Deoxycytidine Kinase Favors the Enzyme Adopting the Open Conformation Making It Competent for Nucleoside Binding and Release

    SciTech Connect

    Hazra, Saugata; Szewczak, Andrzej; Ort, Stephan; Konrad, Manfred; Lavie, Arnon

    2012-03-26

    Deoxycytidine kinase (dCK) uses either ATP or UTP as a phosphoryl donor to catalyze the phosphorylation of nucleoside acceptors. The kinetic properties of human dCK are modulated in vivo by phosphorylation of serine 74. This residue is a part of the insert region and is distant from the active site. Replacing the serine with a glutamic acid (S74E variant) can mimic phosphorylation of Ser74. To understand how phosphorylation affects the catalytic properties of dCK, we examined the S74E variant of dCK both structurally and kinetically. We observe that the presence of a glutamic acid at position 74 favors the adoption by the enzyme of the open conformation. Glu74 stabilizes the open conformation by directly interacting with the indole side chain of Trp58, a residue that is in the proximity of the base of the nucleoside substrate. The open dCK conformation is competent for the binding of nucleoside but not for phosphoryl transfer. In contrast, the closed conformation is competent for phosphoryl transfer but not for product release. Thus, dCK must make the transition between the open and closed states during the catalytic cycle. We propose a reaction scheme for dCK that incorporates the transition between the open and closed states, and this serves to rationalize the observed kinetic differences between wild-type dCK and the S74E variant.

  20. Glycopeptide-membrane interactions: glycosyl enkephalin analogues adopt turn conformations by NMR and CD in amphipathic media.

    PubMed

    Palian, Michael M; Boguslavsky, V I; O'Brien, David F; Polt, Robin

    2003-05-14

    Four enkephalin analogues (Tyr-D-Thr-Gly-Phe-Leu-Ser-CONH(2), 1, and the related O-linked glycopeptides bearing the monosaccharide beta-glucose, 2, the disaccharide beta-maltose, 3, and the trisaccharide beta-maltotriose, 4) were synthesized, purified by HPLC, and biophysical studies were conducted to examine their interactions with membrane model systems. Glycopeptide 2 has been previously reported to penetrate the blood-brain barrier (BBB), and produce potent analgesia superior to morphine in mice (J. Med. Chem.2000, 43, 2586-90 and J. Pharm. Exp. Ther. 2001, 299, 967-972). The parent peptide and its three glycopeptide derivatives were studied in aqueous solution and in the presence of micelles using 2-D NMR, CD, and molecular mechanics (Monte Carlo studies). Consistent with previous conformational studies on cyclic opioid agonist glycopeptides, it was seen that glycosylation did not significantly perturb the peptide backbone in aqueous solution, but all four compounds strongly associated with 5-30 mM SDS or DPC micelles, and underwent profound membrane-induced conformational changes. Interaction was also observed with POPC:POPE:cholesterol lipid vesicles (LUV) in equilibrium dialysis experiments. Although the peptide backbones of 1-4 possessed random coil structures in water, in the presence of the lipid phase they each formed a nearly identical pair of structures, all with a stable beta-turn motif at the C-terminus. Use of spin labels (Mn(2+) and 5-DOXYL-stearic acid) allowed for the determination of the position and orientation of the compounds relative to the surface of the micelle. PMID:12733923

  1. The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication

    PubMed Central

    Sherpa, Chringma; Rausch, Jason W.; Le Grice, Stuart F.J.; Hammarskjold, Marie-Louise; Rekosh, David

    2015-01-01

    The HIV Rev protein forms a complex with a 351 nucleotide sequence present in unspliced and incompletely spliced human immunodeficiency virus (HIV) mRNAs, the Rev response element (RRE), to recruit the cellular nuclear export receptor Crm1 and Ran-GTP. This complex facilitates nucleo-cytoplasmic export of these mRNAs. The precise secondary structure of the HIV-1 RRE has been controversial, since studies have reported alternative structures comprising either four or five stem-loops. The published structures differ only in regions that lie outside of the primary Rev binding site. Using in-gel SHAPE, we have now determined that the wt NL4-3 RRE exists as a mixture of both structures. To assess functional differences between these RRE ‘conformers’, we created conformationally locked mutants by site-directed mutagenesis. Using subgenomic reporters, as well as HIV replication assays, we demonstrate that the five stem-loop form of the RRE promotes greater functional Rev/RRE activity compared to the four stem-loop counterpart. PMID:25855816

  2. A chair on alternatives?

    PubMed

    Spielmann, Horst

    2002-01-01

    An overview is given on the legal framework in Europe for the use of experimental animals set by EU (European Union) Directive 86/609/EEC and on the activities of EU member states to implement this directive in the field of regulatory testing in animals. The significant decrease in the number of experimental animals in Germany during the past decade is described with particular reference to the recent increase that is due to transgenic animal models. From the regulatory and the animal welfare perspective the international harmonisation of test guidelines and the mutual acceptance of data are the way forward for chemical safety testing. The recent White Paper of the EU Commission for the future chemicals policy calls for an immediate increase in the number of validated in vitro toxicity tests to be accepted for regulatory purposes in the EU. In addition, deficits of properly educating young scientists in Germany in conducting animal experiments and implementing the 3-Rs concept of Russel and Burch are described. It is therefore, quite urgent to establish new chairs on animals and alternatives at universities in Europe. They should focus on both education young students of the biomedical sciences in the humane use of laboratory animals according to the 3-Rs concept and on developing new toxicity tests to be validated for regulatory purposes under the new EU chemicals policy by the established validation centres in Europe. PMID:12098012

  3. [How Charcot got his chair].

    PubMed

    Gelfand, T

    1994-01-01

    Charcot's career, as is well-known, reached a summit with his acquisition of the Faculty clinical chair of diseases of the nervous system inaugurated in 1882. Based upon previously untapped archival materials at the Charcot Library and the National Archives, this paper explores four questions: I. Was "Charcot's chair" really the first specialized chair for neurology?; 2. Was it founded specifically for Charcot?; 3. What role did the Faculty of Medicine play and did it offer any opposition?; 4. How important was the creation of the chair for the flourishing of the Salpêtrière school. Evidence is presented to show that Charcot considered a specialized chair in nervous diseases a high priority for his career and his school. Sometime around 1880, convinced of the importance of this project, he began to assemble arguments in its behalf from French and foreign sources, particularly from his German colleagues, Westphal and Erb. He learned that there were no precedents, not even in Berlin. Charcot's carefully prepared manuscript memoir presented a strong case for the "necessity" of the chair based on the recent progress and theoretical as well as practical importance of his subject. He described psychiatry, which already had a Faculty clinical chair, as but a "small part" of neuropathology and rejected the idea of combining the two disciplines. Although the project encountered opposition from several Faculty colleagues, who claimed that it was a personal favor for Charcot, powerful support from political allies such as Gambetta and Ferry ensured government funding. In fact, government action in behalf of the creation of the chair for Charcot preceded and surprised the medical Faculty. This paper shows the extent to which Charcot's own initiatives and arguments set the agenda and defined the role he envisaged for the new foundation at the center of the clinical research and teaching centre emerging under his direction at the Salpêtrière. PMID:11640483

  4. A rocking chair type all-solid-state lithium ion battery adopting Li2O-ZrO2 coated LiNi0.8Co0.15Al0.05O2 and a sulfide based electrolyte

    NASA Astrophysics Data System (ADS)

    Ito, Seitaro; Fujiki, Satoshi; Yamada, Takanobu; Aihara, Yuichi; Park, Youngsin; Kim, Tae Young; Baek, Seung-Wook; Lee, Jae-Myung; Doo, Seokgwang; Machida, Nobuya

    2014-02-01

    An all-solid-state lithium-ion battery (ASSB) using non-flammable solid electrolytes is a candidate for a next-generation battery. Although the excellent cycle performance and its high energy density are suggested in the literature, a practical size battery has not been appeared yet. In this paper, we have adopted a sulfide based electrolyte, Li2S-P2S5 (80:20 mol%) to a rocking chair type lithium ion battery. The electrochemical cell consists of a Li2O-ZrO2 coated LiNi0.8Co0.15Al0.05O2 (NCA) cathode, an artificial graphite anode and the sulfide based electrolyte without any organic and inorganic liquids. The cathode charge transfer resistance is significantly reduced by the Li2O-ZrO2 coating. The total cell resistance of the Li2O-ZrO2 (LZO) coated NCA adopted cell is approximately one quarter of non-treated one. A standard type single cell with the nominal capacity of 100 mAh at 25 °C is fabricated by wet printing process, and its capacity retention is approximately 80% at 100 cycles. Also, a 1 Ah class battery was constructed by stacking the single cells, and demonstrated.

  5. Permeabilization and fusion of uncharged lipid vesicles induced by the HIV-1 fusion peptide adopting an extended conformation: dose and sequence effects.

    PubMed Central

    Pereira, F B; Goñi, F M; Muga, A; Nieva, J L

    1997-01-01

    The peptide HIV(arg), corresponding to a sequence of 23 amino acid residues at the N-terminus of HIV-1 gp41 (LAV1a strain), has the capacity to destabilize negatively charged large unilamellar vesicles. As revealed by infrared spectroscopy, the peptide associated with those vesicles showed conformational polymorphism: in the absence of cations the main structure was a pore-forming alpha-helix, whereas in the presence of Ca2+ the conformation switched to a fusogenic, predominantly extended beta-type structure. Here we show that an extended structure can also be involved in electrically neutral vesicle destabilization induced by the HIV-1 fusion peptide when it binds the vesicle from the aqueous phase. In the absence of cations, neutral liposomes composed of phosphatidylcholine, phosphatidylethanolamine, and cholesterol (molar ratio 1:1:1) selected for an extended structure that became fusogenic in a dose-dependent fashion. At subfusogenic doses this structure caused the release of trapped 8-aminonaphtalene-1,3,6-trisulfonic acid sodium salt/p-xylenebis(pyridinium)bromide from liposomes, indicating the existence of a peptide-mediated membrane destabilizing process before and independent of the development of fusion. When compared to HIV(arg), the fusion activity of HIV(ala) (bearing the R22 --> A substitution) was reduced by 70%. Fusogenicity was completely abolished when a second substitution (V2 --> E) was included to generate HIV(ala-E2), a sequence representing the N-terminus of an inactive gp41. However, the three sequences associated with vesicles to the same extent, and the three adopted a similar extended structure in the membrane. Whereas 1-(4-trimethylaminophenyl)-6-phenyl-1,3,5-hexatriene emission anisotropy was unaffected by the three peptides, DPH emission anisotropy in membranes was increased only by the fusogenic sequences. Taken together, our observations strongly argue that it is not an alpha-helical but an extended structure adopted by the HIV-1

  6. 5-Oxocyclooctanecarboxylic acid: hydrogen-bonding pattern and conformational disorder in a medium-ring varepsilon-keto acid

    PubMed

    Lalancette; Brunskill; Thompson

    2000-10-01

    Molecules of the title compound, C(9)H(14)O(3), adopt a chiral 'boat-chair' conformation, in which the carboxyl group avoids potential cross-ring ketone interactions by an outward 'equatorial' orientation. The asymmetric unit contains two such molecules, one conformationally fixed without disorder, (I), and the other, (I'), extensively disordered, both in the bond lengths and angles of the carboxyl and by a coupled 'up-down' conformational disordering [ratio of 60:40 (1)] of the remote ends of the boat-chair system. Each molecule in the asymmetric unit forms a centrosymmetric hydrogen-bonded carboxyl dimer with a second molecule of its own type. For (I), O.O = 2.658 (3) A and O-H.O = 174 degrees. For (I'), O.O = 2.653 (3) A and O-H.O = 165 degrees. A number of intermolecular C=O.H-C close contacts are found. PMID:11025318

  7. Conformation of some sparteine N-16 oxides revisited

    NASA Astrophysics Data System (ADS)

    Thiel, Jacek; Boczoń, Władysław; Fiedorow, Piotr; Jasiewicz, Beata; Knychała, Małgorzata

    2002-12-01

    Sparteine N-16 oxides were thought to occur in all chair conformations with cis fusion between their C and D rings. NMR spectral analysis made possible indication of the chair- chair- boat- chair form with cis fussion of C, D rings for sparteine, 2-phenyl- and 2-methylsparteine N-16 oxides. Molecular energy found by means of DFT, Hartree-Fock, AM1, PM3 methods supported this new shape of bisquinolizidine skeleton.

  8. Investigation of the role of stereoelectronic effects in the conformation of piperidones by NMR spectroscopy and X-ray diffraction.

    PubMed

    Garcias-Morales, Cesar; Ortegón-Reyna, David; Ariza-Castolo, Armando

    2015-01-01

    This paper reports the synthesis of a series of piperidones 1-8 by the Mannich reaction and analysis of their structures and conformations in solution by NMR and mass spectrometry. The six-membered rings in 2,4,6,8-tetraphenyl-3,7-diazabicyclo[3.3.1]nonan-9-ones, compounds 1 and 2, adopt a chair-boat conformation, while those in 2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ones, compounds 3-8, adopt a chair-chair conformation because of stereoelectronic effects. These stereoelectronic effects were analyzed by the (1) J C-H coupling constants, which were measured in the (13)C satellites of the (1)H NMR spectra obtained with the hetero-dqf pulse sequence. In the solid state, these stereoelectronic effects were investigated by measurement of X-ray diffraction data, the molecular geometry (torsional bond angles and bond distances), and inter- and intramolecular interactions, and by natural bond orbital analysis, which was performed using density functional theory at the ωB97XD/6311++G(d,p) level. We found that one of the main factors influencing the conformational stability of 3-8 is the interaction between the lone-pair electrons of nitrogen and the antibonding sigma orbital of C(7)-Heq (nN→σ*C-H(7)eq), a type of hyperconjugative interaction. PMID:26664617

  9. A Tale of Three Chairs.

    ERIC Educational Resources Information Center

    Carnes, Jim

    1998-01-01

    Drawing from the work of Henry David Thoreau, urges us to see the relationship between the individual and his/her community. Thoreau had three chairs in his cabin: one for solitude, one for friendship, and one for society. Like Thoreau, school leaders could make a career of exploring the tension between public and private imperatives. (MLH)

  10. 21 CFR 886.1140 - Ophthalmic chair.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ophthalmic chair. 886.1140 Section 886.1140 Food... DEVICES OPHTHALMIC DEVICES Diagnostic Devices § 886.1140 Ophthalmic chair. (a) Identification. An ophthalmic chair is an AC-powered or manual device with adjustable positioning in which a patient is to...

  11. Robotic chair at steep and narrow stairways

    NASA Astrophysics Data System (ADS)

    Imazato, Masahiro; Yamaguchi, Masahiro; Moromugi, Shunji; Ishimatsu, Takakazu

    2007-12-01

    A robotic chair is developed to support mobility of elderly and disabled people living in the house where steep and narrow stairways are installed. In order to deal with such mobility problem the developed robotic chair has a compact original configuration. The robotic chair vertically moves by actuation of electric cylinders and horizontally moves by push-pull operation given by a care-giver. In order to navigate safely every action of the chair is checked by the operator. Up-and-down motions of the robotic chair on the stairway are executed through combinations of motor and cylinder actuations. Performance of the robotic chair was evaluated through two kinds of experiments. The excellent ability of the robotic chair could be confirmed through these experiments.

  12. The Department Chair: Between a Rock and a Hard Place.

    ERIC Educational Resources Information Center

    Wilson, Vicki

    This paper provides a review of the literature on the roles and responsibilities of the academic departmental chair in colleges and universities. Carroll and Gmelch (1992) found four orientations in a factor analysis of department chair duties: leader chairs, scholar chairs, faculty developer chairs, and manager chairs. Creswell and Brown (1992)…

  13. Chair like NiAu6: Clusters assemblies and CO oxidation study by ab initio methods

    NASA Astrophysics Data System (ADS)

    Nigam, Sandeep; Sahoo, Suman Kalyan; Sarkar, Pranab; Majumder, Chiranjib

    2013-10-01

    Based on the first-principles approach, this Letter reports that the ground state geometry of the Ni@Au6 cluster forms chair-like conformation, which is distinctly different than the Pd@Au6 and Pt@Au6 clusters, where hexagonal planar structure is favored over non-planar isomers. The higher stability of the chair-like conformation has been verified through various complementary basis sets and methodologies. Further investigations were carried out to show the stability of a cluster assembled material (CAM) based on these small clusters and the CO oxidation reaction was carried out to establish their uses as an industrial catalyst.

  14. Improved Atomistic Monte Carlo Simulations Demonstrate that Poly-L-Proline Adopts Heterogeneous Ensembles of Conformations of Semi-Rigid Segments Interrupted by Kinks

    PubMed Central

    Radhakrishnan, Aditya; Vitalis, Andreas; Mao, Albert H.; Steffen, Adam T.; Pappu, Rohit V.

    2012-01-01

    Poly-L-proline (PLP) polymers are useful mimics of biologically relevant proline-rich sequences. Biophysical and computational studies of PLP polymers in aqueous solutions are challenging because of the diversity of length scales and the slow time scales for conformational conversions. We describe an atomistic simulation approach that combines an improved ABSINTH implicit solvation model, with conformational sampling based on standard and novel Metropolis Monte Carlo moves. Refinements to forcefield parameters were guided by published experimental data for proline-rich systems. We assessed the validity of our simulation results through quantitative comparisons to experimental data that were not used in refining the forcefield parameters. Our analysis shows that PLP polymers form heterogeneous ensembles of conformations characterized by semi-rigid, rod-like segments interrupted by kinks, which result from a combination of internal cis peptide bonds, flexible backbone ψ-angles, and the coupling between ring puckering and backbone degrees of freedom. PMID:22329658

  15. Pyranose sulfamates: conformation and hydrogen bonding

    NASA Astrophysics Data System (ADS)

    Kubicki, Maciej; Codding, Penelope W.; Litster, Stephen A.; Szkaradziñska, Maria B.; Bassyouni, Hanan A. R.

    1999-01-01

    The crystal structure of a new anticonvulsant drug, topiramate — 2,3:4,5-bis- O-(1-methylethylidene)- β-D-fructopyranose sulfamate ( 1), together with those of three similar but biologically almost inactive sugar sulfamates: 4,5- O-cyclohexylidene-2,3- O-(1-methyl-ethylidene)- β-D-fructopyranose sulfamate ( 2), 2,3:- O-(1-methylethylidene)- β-D-fructo-pyranose sulfamate ( 3), and 1,2:3,4-bis- O-(1-methylethylidene)- α-D-galactopyranose sulfamate ( 4), have been determined by X-rays. The pyranose rings adopt distorted twist-boat 2S O conformations as a result of flattening of the chair conformation, observed in free pyranoses, by the fused five-membered ring(s). In 3 an unfavourable gauche-trans conformation about C1-C2 bond is observed. The active compound, topiramate ( 1), shows, in comparison with the other three compounds, a different disposition of nitrogen and oxygen atoms from the sulfamate group with respect to the O1-S1 bond. As a result, the nitrogen atom in 1 is ca. 1 Å farther from the O6 pyranose ring oxygen atom than in the other three compounds. This difference describes the mutual disposition of the hydrophilic and hydrophobic parts of the molecule, and can be related to the difference in biological activity. In all compounds, hydrogen bonds connect molecules into three-dimensional networks; simple chains and more complicated rings are found and described using the graph set notation.

  16. 21 CFR 890.3100 - Mechanical chair.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Mechanical chair. 890.3100 Section 890.3100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3100 Mechanical chair....

  17. 21 CFR 890.3100 - Mechanical chair.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Mechanical chair. 890.3100 Section 890.3100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3100 Mechanical chair....

  18. 21 CFR 890.3100 - Mechanical chair.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Mechanical chair. 890.3100 Section 890.3100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3100 Mechanical chair....

  19. 21 CFR 890.3100 - Mechanical chair.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Mechanical chair. 890.3100 Section 890.3100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3100 Mechanical chair....

  20. Chairs of Graduate Departments: A Structural Profile.

    ERIC Educational Resources Information Center

    Van Valey, Thomas L.; Tiemann, Kathleen

    1990-01-01

    Analyzes all U. S. sociology departments listed in the American Sociological Association Guide to Graduate Departments of Sociology from 1969 to 1985 with respect to the backgrounds of chairs as well as selected structural characteristics of their departments. Finds that chairs who are male and who hold the rank of full professor continue to be…

  1. 21 CFR 890.3100 - Mechanical chair.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Mechanical chair. 890.3100 Section 890.3100 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3100 Mechanical chair....

  2. Enhancing the Effectiveness of Department Chairs

    ERIC Educational Resources Information Center

    Lumpkin, Angela

    2004-01-01

    The department chair is one of the most challenging positions in higher education. Advancing one's department can occur by attending to the parameters that highly successful organizations have implemented. In addition to outlining the challenges of serving as a department chair, this article describes four requirements for dealing with, and…

  3. Secondary School Science Department Chairs Leading Change

    ERIC Educational Resources Information Center

    Gaubatz, Julie A.

    2012-01-01

    Secondary school department chairs are content area specialists in their schools and are responsible for providing students with the most appropriate curricula. However, most secondary school department chairs have limited authority to institute change unilaterally (Gmelch, 1993; Hannay & Erb, 1999). To explore how these educational leaders…

  4. Who Will Be Your Next Board Chair?

    ERIC Educational Resources Information Center

    Wilson, E. B.

    2004-01-01

    This article suggests that trustees give the same high level of thoughtful consideration to selecting the board chair as they give to filling the presidency. More than the routine filling of a vacancy, the process for naming the board's next chair amounts to the selection of a governance team. The board's most important responsibility is not only…

  5. Probing of different conformations of piperazine using Raman spectroscopy

    NASA Astrophysics Data System (ADS)

    SenGupta, Sumana; Maiti, Nandita; Chadha, Ridhima; Kapoor, Sudhir

    2014-06-01

    Piperazine exists in a number of energetically close structural conformations, and here, we investigated the dependence of their relative abundance on the surrounding conditions by using Raman and SERS spectroscopy in pure solid, aqueous solution and Ag hydrosol. The experimental results were interpreted by DFT calculations using B3LYP functional with aug-cc-pvdz/LANL2DZ basis sets. In the chair form of piperazine, which is more stable than the skewed boat by ∼8 kcal mol-1, the two N-H bonds can remain equatorial or axial, leading to three different conformations, eq-eq, eq-ax and ax-ax. The calculated Raman spectrum of the lowest energy eq-eq conformation corresponds well with the experimental spectrum in pure solid, indicating eq-eq to be predominant. But, the contribution of the eq-ax conformation was found to be maximum in aqueous solution. The SERS spectrum revealed that eq-ax conformation was preferably adopted as piperazine was adsorbed vertically through its axial N-atom over silver nanoparticle surface.

  6. Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation.

    PubMed

    Schmitz, M L; dos Santos Silva, M A; Altmann, H; Czisch, M; Holak, T A; Baeuerle, P A

    1994-10-14

    The p65 subunit of the NF-kappa B transcription factor contains in its C-terminal 120 amino acids at least two transcription activation domains. One domain (TA1) is contained within only the 30 C-terminal amino acids. Structural studies employing CD and NMR spectroscopy revealed that the TA1 domain is unstructured. NMR analysis of a protein corresponding to the C-terminal 123 amino acids also showed a random coil conformation. However, a portion of TA1 was found to adopt an alpha-helical conformation in the presence of hydrophobic solvents. Transcriptional analysis of point mutants revealed the functional importance of two evolutionary conserved sequence repeats, which are located in the conditionally alpha-helical region of TA1. These repeats acted synergistically in transcription activation. The inhibitory effect of some mutants indicated secondary structure constraints on TA1 in intact cells. Inverting the sequence of two acidic activation domains significantly reduced their transactivating potential, suggesting that amino acid composition is not solely essential for activity; a defined primary structure is necessary as well. Acidic sequence motifs related in primary structure and squelching activity to those of TA1 are present in the activation domains of VP16, c-Rel, and several other transcription factors. We propose a model suggesting that primarily unstructured acidic activation domains can adopt a secondary structure upon contacting their target molecules by an "induced fit" mechanism. PMID:7929265

  7. 2011 AGU Workshop for Heads & Chairs

    NASA Astrophysics Data System (ADS)

    Fox, Lydia K.; Asher, Pranoti

    2012-02-01

    The AGU Board of Heads & Chairs of Departments of Earth and Space Sciences (H&C) held its annual workshop on Sunday, 4 December, at the 2011 Fall Meeting. The workshop included presentations on successful strategies for various aspects of the role of department head or chair, as well as time for small group discussions and networking among the group. There were nearly 60 participants, representing all stages of the chair life cycle, from seasoned veterans to those about to assume the role. Participants also represented a variety of institution types, both public and private, from 2-year colleges to research universities.

  8. Toward Consistent Terminology for Cyclohexane Conformers in Introductory Organic Chemistry

    ERIC Educational Resources Information Center

    Nelson, Donna J.; Brammer, Christopher N.

    2011-01-01

    Recommended changes in use of cyclohexane conformers and their nomenclature will remedy inconsistencies in cyclohexane conformers and their nomenclature that exist across currently used organic chemistry textbooks. These inconsistencies prompted this logical analysis and the resulting recommendations. Recommended conformer names are "chair",…

  9. Conformational Analysis of a Dermatan Sulfate-Derived Tetrasaccharide by NMR, Molecular Modeling, and Residual Dipolar Couplings

    PubMed Central

    Silipo, Alba; Zhang, Zhenqing; Cañada, F. Javier; Molinaro, Antonio

    2014-01-01

    The solution conformation behavior of a dermatan-derived tetrasaccharide—ΔHexA-(1→3)-GalNAc4S-β-(1→4)-IdoA-α-(1→3)-red-GalNAc4S (S is a sulfate group)—has been explored by means of NMR spectroscopy, especially by NOE-based conformational analysis. The tetrasaccharide was present as four species, two of which are chemically different in the anomeric orientation of the reducing 2-deoxy-2-acetamido-galactose (red-GalNAc) residue, while the other two are the result of different conformations of the iduronic acid (IdoA) unit. The two α–-interconverting anomers were present in a 0.6:1 ratio. Ring conformations have been defined by analysis of 3JH,H coupling constants and interresidual NOE contacts. Both 2-deoxy-2-acetamido-galactose (GalNAc) residues were found in the 4C1 chair conformation, the unsaturated uronic acid (Δ-Hex A) adopts a strongly predominant half-chair 1H2 conformation, while the IdoA residue exists either in the 1C4 chair or in the 2S0 skewed boat geometries, in a 4:1 ratio. There is a moderate flexibility of Φ and Ψ torsions as suggested by nuclear Overhauser effects (NOEs), molecular modeling (MM), and molecular dynamics (MD) studies. This was further investigated by residual dipolar couplings (RDCs). One-bond C–H RDCs (1DC,H) and long-range H–H (3DH,H) RDCs were measured for the tetrasaccharide in a phage solution and interpreted in combination with restrained MD simulation. The RDC-derived data substantially confirmed the validity of the conformer distribution resulting from the NOE-derived simulations, but allowed an improved definition of the conformational behavior of the oligosaccharides in solution. In summary, the data show a moderate flexibility of the four tetrasaccharide species at the central glycosidic linkage. Differences in the shapes of species with the IdoA in skew and in chair conformations and in the distribution of the sulfate groups have also been highlighted. PMID:18072186

  10. The Disintegrating Chair: Professors in Britain Today.

    ERIC Educational Resources Information Center

    Moodie, Graeme

    1986-01-01

    Changes in the status of the British "chair" or professorship in the twentieth century are examined, with focus on the types of changes, the reasons for them, and the administrative, educational, and intellectual results. (MSE)

  11. Chair Talk: Resources to Maximize Administrative Efforts

    NASA Astrophysics Data System (ADS)

    MacDonald, H.; Chan, M. A.; Bierly, E. W.; Manduca, C. A.; Ormand, C. J.

    2009-12-01

    Earth science department chairs are generally scientists who have little/no formal administrative training. The common rotation of faculty members in three-six year cycles distributes the heavy leadership responsibilities but involves little preparation beforehand to deal with budgets, fundraising, personnel issues, confrontations, and crises. The amount of information exchange and support upon exit and handoff to the next chair is variable. Resources for chairs include workshops, meetings (ranging from annual meetings of geoscience chairs to monthly meetings of small groups of chairs from various disciplines on a campus), discussions, and online resources. These resources, some of which we designed in the past several years, provide information and support for chairs, help them share best practices, and reduce time spent “reinventing the wheel”. Most of these resources involve groups of chairs in our discipline who meet together. The AGU Board of Heads and Chairs of Earth and Space Science Departments offers annual one-day workshops at the Fall AGU meeting. The specific topics vary from year to year; they have included goals and roles of heads and chairs, fundraising and Advisory Boards, student recruitment, interdisciplinarity, dual-career couples, and undergraduate research. The workshop provides ample opportunities for open discussion. Annual one-two day meetings of groups of geoscience department chairs (e.g., research universities in a particular region) provide an opportunity for chairs to share specific data about their departments (e.g., salaries, graduate student stipends, information about facilities) and discuss strategies. At the College of William and Mary, a small group of chairs meets monthly throughout the year; each session includes time for open discussion as well as a more structured discussion on a particular topic (e.g., merit review, development and fundraising, mentoring early career faculty and the tenure process, leadership styles

  12. Secondary school science department chairs leading change

    NASA Astrophysics Data System (ADS)

    Gaubatz, Julie A.

    Secondary school department chairs are content area specialists in their schools and are responsible for providing students with the most appropriate curricula. However, most secondary school department chairs have limited authority to institute change unilaterally (Gmelch, 1993; Hannay & Erb, 1999). To explore how these educational leaders navigate the change process within their departments, this study examined the change stories of six secondary school science department chairs who had led change attempts. In total, these department chairs shared six stories of successful change attempts and four unsuccessful change attempts. The topics of leadership and change were accessed through department chair interviews, document analysis, and a leadership inventory. Department chair leadership was analyzed with Blake and McCanse's (1991) Leadership Grid, and further explored using Yukl, Gordon, and Taber's (2002) detailed characterization of this grid. The change processes described in these department chair stories were analyzed using the frameworks provided by Ely's (1990) conditions of change, and Havelock and Zlotolow (1995) CREATER change stages model. In general, the findings of this study support Havelock and Zlotolow's CREATER model, as well as Ely's conditions of change, with dissatisfaction with the status quo emerging as the essential condition for successful change. This study connects these change process frameworks to specific leadership strategies and behaviors, and uses these connections to illuminate differences between successful and unsuccessful instances of change. These findings, along with other unanticipated findings emerging from department chair stories of change, such as the adverse influence of contentious resistors and the importance of team construction, add both to the literature on change and leadership and to the crucial point where these concepts intersect.

  13. Conformations of [(R,R)-1,5-diaza-cis-decalin] copper (II) complex and its hydrogen bonding interaction with the crystal water: A combined experimental VA, UV-Vis and ECD spectroscopic and DFT study

    NASA Astrophysics Data System (ADS)

    Dezhahang, Zahra; Poopari, Mohammad Reza; Xu, Yunjie

    2012-09-01

    Chiral 1,5-diaza-cis-decalin ligand and its copper-complexes have found considerable applications in catalyzing enantioselective organic reactions. In the present article, (R,R)-1,5-diaza-cis-decalin ligand and its copper (II) hydroxide iodine hydrate complex have been investigated by using vibrational absorption (VA), ultraviolet-visible (UV-Vis), and electronic circular dichroism (ECD) experimental spectroscopic measurements, as well as density functional theory modeling. An extensive theoretical conformational analysis of the ligand has revealed that the ligand can adopt a good number of orientations in terms of its frame conformations, i.e. Chair-Chair, Chair-Boat, and Boat-Boat, the proximal (also denoted as in) and distal (out) positions for its two N atoms, and the equatorial (e) and axial (a) positions of its two amine H atoms. The most dominant conformation at room temperature was predicted to take on the Chair-Chair N-in H-ea configuration, based on the relative Gibbs free energy ordering at the B3LYP/6-31++G(d,p) level. The VA, vibrational CD, UV-Vis, and ECD spectra of the ligand conformers have been simulated. Conformational searches have also been carried out for the titled copper complex at the B3LYP/LanL2DZ level and the dominant conformer was predicted to have the Chair-Chair N-in H-ee configuration for its ligands, with a close to 100% Boltzmann population factor at room temperature. Furthermore, geometry optimizations and spectral simulations have been performed for the hydrogen bonded cluster of the complex with the crystal water. The effects of hydrogen bonding interaction with the crystal water on the VA, VCD, UV-Vis, and ECD spectra have been discussed. The interaction with the water molecule has been found to have significant impacts on the appearance of VA, VCD and ECD spectra and its inclusion is essential to obtain satisfactory interpretations of the experimental VA and ECD spectra.

  14. The Cost of Academic Leadership: Department Chair Stress.

    ERIC Educational Resources Information Center

    Gmelch, Walter H.; Burns, John S.

    Findings from a study that examined stresses associated with the role of the university department chair are presented in this paper. The focuses are on career paths, transitions to the chair position, commitment to administration, role orientation, and strains of chairing. A survey of 808 department chairs in 101 research and doctoral-granting…

  15. Synthesis, characterisation, conformational preferences, dynamic NMR studies and antimicrobial evaluation of N-nitroso- and N-formyl-c-3,t-3-dimethyl-r-2,c-7-diphenyl-1,4-diazepan-5-ones

    NASA Astrophysics Data System (ADS)

    Ponnuswamy, S.; Akila, A.; Kiruthiga devi, D.; Maheshwaran, V.; Ponnuswamy, M. N.

    2016-04-01

    The stereochemical preferences of N-nitroso- and N-formyl-c-3,t-3-dimethyl-r-2,c-7-diphenyl-1,4-diazepan-5-ones 3 & 4, respectively, have been determined using 1D and 2D NMR spectral techniques. Interestingly, the N-nitroso compound 3 is found to prefer an equilibrium between alternate chair conformations with diaxial phenyl groups, while the N-formyl compound 4 prefers flattened boat conformation. This is stereochemically a novel report on the flexible rings adopting a chair conformation with diaxial phenyl groups. The X-ray crystal structure of N-nitroso-c-3,t-3-dimethyl-r-2,c-7-diphenyl-1,4-diazepan-5-one (3) also supports the chair conformation with diaxial phenyl groups. Dynamic 1H NMR spectral studies have been carried out on the N-nitroso and N-formyl diazepan-5-ones 3 &4 and the energy barriers for N-NO and N-CO rotations are found to be 88.7 and 75.7 kJ/mol, respectively. The antimicrobial activities have been determined for the compounds 2-4 and it is found that all the compounds exhibit significant antibacterial and antifungal activities when compared to the standard chloramphenicol.

  16. Skylab experiment M131: Rotating little chair

    NASA Technical Reports Server (NTRS)

    Evans, J. S.; Zitterkopf, D. L.; Konigsberg, R. L.; Blackburn, C. M.

    1977-01-01

    Physiological considerations suggest that the response of the vestibular system can be substantially modified during weightlessness and that such modifications affect susceptibility to motion sickness and to judgment of spatial localization. Evaluation of such effects requires measurement of responses to rotational accelerations before, during, and after exposure to conditions of prolonged zero-gravity. For this purpose, a precisely controlled rotating chair was designed, constructed, tested, and installed in the Skylab Orbital Workshop. The chair was used in three test modes to measure changes in the vestibular (balance) organs of the astronauts.

  17. Quality Improvement Practices in Academic Emergency Medicine: Perspectives from the Chairs

    PubMed Central

    DelliFraine, Jami; Langabeer, James; King, Brent

    2010-01-01

    Objective To assess academic emergency medicine (EM) chairs’ perceptions of quality improvement (QI) training programs. Methods A voluntary anonymous 20 item survey was distributed to a sample of academic chairs of EM through the Association of Academic Chairs of Emergency Medicine. Data was collected to assess the percentage of academic emergency physicians who had received QI training, the type of training they received, their perception of the impact of this training on behavior, practice and outcomes, and any perceived barriers to implementing QI programs in the emergency department. Results The response rate to the survey was 69% (N = 59). 59.3% of respondents report that their hospital has a formal QI program for physicians. Chairs received training in a variety of QI programs. The type of QI program used by respondents was perceived as having no impact on goals achieved by QI (χ2 = 12.382; p = 0.260), but there was a statistically significant (χ2 = 14.383; p = 0.006) relationship between whether or not goals were achieved and academic EM chairs’ perceptions about return on investment for QI training. Only 22% of chairs responded that they have already made changes as a result of the QI training. 78.8% of EM chairs responded that quality programs could have a significant positive impact on their practice and the healthcare industry. Chairs perceived that QI programs had the most potential value in the areas of understanding and reducing medical errors and improving patient flow and throughput. Other areas of potential value of QI include improving specific clinical indicators and standardizing physician care. Conclusion Academic EM chairs perceived that QI programs were an effective way to drive needed improvements. The results suggest that there is a high level of interest in QI but a low level of adoption of training and implementation. PMID:21293770

  18. A carpet-weaver's chair based on anthropometric data.

    PubMed

    Mahmoudi, Nader; Bazrafshan, Majid

    2013-01-01

    Ergonomic design of chairs has been well studied by ergonomists. Chair design based on anthropometric data analysis is recommended. Weavers in carpet-weaving workshops use chairs with backrests and armrests. An anthropometric survey was carried out among weavers in Tabriz, Iran, to design a flexible chair and to improve its comfort on the basis of design dimensions. This study focused on the design dimensions of a chair for weavers and its recommended dimensions. The developed chair needs to be tested for its effects on weavers' posture and comfort. PMID:24321633

  19. The future-oriented department chair.

    PubMed

    Grigsby, R Kevin; Hefner, David S; Souba, Wiley W; Kirch, Darrell G

    2004-06-01

    The authors describe the current dilemma facing academic health centers (AHCs) as they recruit department chairs. In the past, leaders at AHCs predominantly were concerned with fulfilling the esteemed tripartite missions of patient care, research, and education. Today, their time and energy are occupied by a different set of tasks that have a distinct business orientation, including winning contracts, enhancing revenue, reducing costs, recruiting and managing a diverse workforce, and dealing with consumer satisfaction and marketing. New visions and strategies must be developed--requiring different dimensions of leadership. The authors offer concrete recommendations for recruiting, retaining, and sustaining department chairs, and argue that a deliberative, thoughtful process of engaging chair candidates should begin by focusing on the candidates' values as a first priority. Candidates who most clearly share organizational values should then be engaged in an iterative process of developing a shared vision, resulting in a letter of agreement that explicitly states the mutual expectations and commitments of both the organization and the candidate. Once department chairs are in place, ongoing development through leadership training, mentoring, and other investments help to retain and sustain them. PMID:15165977

  20. The Department Chair: A Descriptive Study.

    ERIC Educational Resources Information Center

    Seedorf, Rita G.; Gmelch, Walter H.

    Information is presented on a study which investigated the managerial role of the academic department chair and compared it to a study of traditional managers. The study compared management activities to determine whether or not there was a difference between academic management and management outside of the university setting. It made use of the…

  1. Perceptions of Leadership Styles of Department Chairs

    ERIC Educational Resources Information Center

    Whitsett, Glee

    2007-01-01

    Much has been written about leadership in business management, but very little research has been done on leadership in academic departments. Department chairs have the authority to make most departmental decisions, but rarely does formal training exist for this position. Therefore, there is a need to study how the leadership styles among…

  2. CCCC Chair's Address: Representing Ourselves, 2008

    ERIC Educational Resources Information Center

    Glenn, Cheryl

    2008-01-01

    This article presents the text of the author's address at the fifty-ninth annual convention of the Conference on College Composition and Communication (CCCC) in March 2008. In her address, the author picks up strands of previous Chairs' addresses and weaves them through the fabric of her remarks. What she hopes will give sheen to the fabric is her…

  3. 21 CFR 892.1820 - Pneumoencephalographic chair.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Pneumoencephalographic chair. 892.1820 Section 892.1820 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... pneumoencephalography (x-ray imaging of the brain). (b) Classification. Class II....

  4. 21 CFR 892.1820 - Pneumoencephalographic chair.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Pneumoencephalographic chair. 892.1820 Section 892.1820 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... pneumoencephalography (x-ray imaging of the brain). (b) Classification. Class II....

  5. 21 CFR 892.1820 - Pneumoencephalographic chair.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Pneumoencephalographic chair. 892.1820 Section 892.1820 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... pneumoencephalography (x-ray imaging of the brain). (b) Classification. Class II....

  6. 21 CFR 892.1820 - Pneumoencephalographic chair.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Pneumoencephalographic chair. 892.1820 Section 892.1820 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... pneumoencephalography (x-ray imaging of the brain). (b) Classification. Class II....

  7. 21 CFR 892.1820 - Pneumoencephalographic chair.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Pneumoencephalographic chair. 892.1820 Section 892.1820 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... pneumoencephalography (x-ray imaging of the brain). (b) Classification. Class II....

  8. The Real Work of Department Chair.

    ERIC Educational Resources Information Center

    Bowman, Richard F., Jr.

    2002-01-01

    Argues that secondary and post secondary academic department chairs are both managers and leaders whose real work is to manage conversational inquiry that engages others in creating possibilities, breakthroughs, and a sustainable future for their common enterprise. Describes leadership capabilities demanded by this work; well-honed communication…

  9. Experimental investigation of chair type, row spacing, occupants, and carpet on theatre chair absorption.

    PubMed

    Choi, Young-Ji; Bradley, John S; Jeong, Dae-Up

    2015-01-01

    This paper examines how the individual variations of chair type, row spacing, as well as the presence of occupants and carpet, combine to influence the absorption characteristics of theater chairs as a function of sample perimeter-to-area (P/A) ratios. Scale models were used to measure the interactive effects of the four test variables on the chair absorption characteristics, avoiding the practical difficulties of full scale measurements. All of the test variables led to effects that could lead to important changes to auditorium acoustics conditions. At mid and higher frequencies, the various effects can usually be explained as due to, more or less, porous absorbing material. In the 125 and 250 Hz octave bands, the major changes were attributed to resonant absorbing mechanisms. The results indicate that for accurate predictions of the effective absorption of the chairs in an auditorium, one should use the P/A method and reverberation chamber tests of the chair absorption coefficients to predict the absorption coefficients of each block of chairs and use these results as input in a room acoustics computer model of the auditorium. The application of these results to auditorium acoustics design is described, more approximate approaches are considered, and relations to existing methods are discussed. PMID:25618043

  10. Review of the medical and legal literature on restraint chairs.

    PubMed

    Castillo, Edward M; Coyne, Christopher J; Chan, Theodore C; Hall, Christine A; Vilke, Gary M

    2015-07-01

    Use of restraint chairs by law enforcement for violent individuals has generated controversy and a source of litigation because of reported injuries and deaths of restrained subjects. The purpose of this study is to review the available medical and legal literature and to allow the development of evidence-based, best practice recommendations to inform the further development of restraint chair policies. This is a structured literature review of four databases, two medical and two legal. The medical review focus was on the restraint chair with additional review of materials regarding other restraint methods and options. The legal review focused on litigation cases involving the restraint chair. The review of the medical literature revealed 21 peer-reviewed studies investigating the physiological or psychological effects of using a restraint chair on humans or primates. Of these studies, 20 were performed on primates. The single human study revealed no clinically significant effects from the restraint chair on test subjects. The legal literature review revealed very few cases where the restraint chair was either a major or minor focus. The overall issues relating to the restraint chair cases involved deviations from set protocols and rarely involved issues with the chair itself. The available medical literature reveals that the restraint chair poses little to no medical risk. Additionally, when used appropriately, the restraint chair alone carries little legal liability. With proper monitoring and adherence to set protocols, the restraint chair is a safe and appropriate device for use in restraining violent individuals. PMID:26048505

  11. Science Instructional Leadership: The Role of the Department Chair

    ERIC Educational Resources Information Center

    Peacock, Jeremy S.

    2014-01-01

    With science teachers facing comprehensive curriculum reform that will shape science education for decades to come, high school department chairs represent a critical resource for instructional leadership and teacher support. While the historical literature on the department chair indicates that chairs are in prime positions to provide…

  12. 21 CFR 880.6140 - Medical chair and table.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Medical chair and table. 880.6140 Section 880.6140...) MEDICAL DEVICES GENERAL HOSPITAL AND PERSONAL USE DEVICES General Hospital and Personal Use Miscellaneous Devices § 880.6140 Medical chair and table. (a) Identification. A medical chair or table is a...

  13. 21 CFR 872.6250 - Dental chair and accessories.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Dental chair and accessories. 872.6250 Section 872...) MEDICAL DEVICES DENTAL DEVICES Miscellaneous Devices § 872.6250 Dental chair and accessories. (a) Identification. A dental chair and accessories is a device, usually AC-powered, in which a patient sits....

  14. 21 CFR 872.6250 - Dental chair and accessories.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Dental chair and accessories. 872.6250 Section 872...) MEDICAL DEVICES DENTAL DEVICES Miscellaneous Devices § 872.6250 Dental chair and accessories. (a) Identification. A dental chair and accessories is a device, usually AC-powered, in which a patient sits....

  15. 21 CFR 872.6250 - Dental chair and accessories.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Dental chair and accessories. 872.6250 Section 872...) MEDICAL DEVICES DENTAL DEVICES Miscellaneous Devices § 872.6250 Dental chair and accessories. (a) Identification. A dental chair and accessories is a device, usually AC-powered, in which a patient sits....

  16. 21 CFR 872.6250 - Dental chair and accessories.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Dental chair and accessories. 872.6250 Section 872...) MEDICAL DEVICES DENTAL DEVICES Miscellaneous Devices § 872.6250 Dental chair and accessories. (a) Identification. A dental chair and accessories is a device, usually AC-powered, in which a patient sits....

  17. 21 CFR 872.6250 - Dental chair and accessories.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Dental chair and accessories. 872.6250 Section 872...) MEDICAL DEVICES DENTAL DEVICES Miscellaneous Devices § 872.6250 Dental chair and accessories. (a) Identification. A dental chair and accessories is a device, usually AC-powered, in which a patient sits....

  18. 21 CFR 880.6140 - Medical chair and table.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Medical chair and table. 880.6140 Section 880.6140...) MEDICAL DEVICES GENERAL HOSPITAL AND PERSONAL USE DEVICES General Hospital and Personal Use Miscellaneous Devices § 880.6140 Medical chair and table. (a) Identification. A medical chair or table is a...

  19. Probabilistic model-based methodology for the conformational study of cyclic systems: application to copper complexes double-bridged by phosphate and related ligands.

    PubMed

    Kessler, M; Pérez, J; Bueso, M C; García, L; Pérez, E; Serrano, J L; Carrascosa, R

    2007-12-01

    A methodology for the conformational study of cyclic systems through the statistical analysis of torsion angles is presented. It relies on a combination of different methods based on a probabilistic model which takes into account the topological symmetry of the structures. This methodology is applied to copper complexes double-bridged by phosphate and related ligands. Structures from the Cambridge Structural Database (CSD) are analyzed and the chair, boat-chair and boat conformations are identified as the most frequent conformations. The output of the methodology also provides information about distortions from the ideal conformations, the most frequent being: chair <--> twist-chair, chair <--> twist-boat-chair and boat <--> twist-boat. Molecular mechanics calculations identify these distortions as energetically accessible pathways. PMID:18004042

  20. Samuel P. Massie Chair of Excellence Program

    SciTech Connect

    Johnson, James H

    2014-12-15

    Abstract In 1994 the Department of Energy established the DOE Chair of Excellence Professorship in Environmental Disciplines Program. In 2004, the Massie Chair of Excellence Professor at Howard University transitioned from Dr. Edward Martin to Dr. James H. Johnson, Jr. At the time of his appointment Dr. Johnson served as professor of civil engineering and Dean of the College of Engineering, Architecture and Computer Sciences. Program activities under Dr. Johnson were in the following areas: • Increase the institution’s capacity to conduct scientific research and technical investigations at the cutting-edge. • Promote interactions, collaborations and partnerships between the private sector, Federal agencies, majority research institutes and other HBCUs. • Assist other HBCUs in reaching parity in engineering and related fields. • Mentor young investigators and be a role model for students.

  1. Space Grant Research Launches Rehabilitation Chair

    NASA Technical Reports Server (NTRS)

    2015-01-01

    Working with funding from the National Space Grant College and Fellowship Program-which was implemented by NASA Headquarters to fund research, education, and public service projects-a biomedical engineering student created a vibration-based system that could combat bone loss from prolonged trips to space. A rehabilitation chair incorporating the technology is now sold by Sheboygan, Wisconsin-based VibeTech Inc. and is helping people recover more quickly from injuries and surgery.

  2. Conformational analysis of primary ethylene ozonide by gradient and multiconfigurational scf calculations

    NASA Astrophysics Data System (ADS)

    Ruoff, Peter; Almlöf, Jan; Sæbø, Svem

    1980-06-01

    Four conformers of ethylene primary ozonide have been studied by ab initio gradient and MC SCF calculations, using gaussian-type basis functions. The MC SCF results indicate that the conformers are not as close in energy as suggested from single-determinant SCF calculations. The oxygen-oxygen and carbon-oxygen half-chair structures are much lower in energy than the carbon-carbon half-chair.

  3. Body Mass Measurement Chair - Experiment M172

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Skylab's Body Mass Measurement chair, the facility of the Body Mass Measurement experiment (M172), is shown here in this 1970 photograph. The M172 experiment determined the body mass of each crew member and observed changes in body masses during flight. Knowledge of exact body mass variations throughout the flight in significantly aided in the correlation of other medical data obtained during the flight. Mass measurements under zero-gravity conditions were achieved by the application of Newton's second law (force equals mass times acceleration). The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

  4. Investigation of the role of stereoelectronic effects in the conformation of piperidones by NMR spectroscopy and X-ray diffraction

    PubMed Central

    Garcias-Morales, Cesar; Ortegón-Reyna, David

    2015-01-01

    Summary This paper reports the synthesis of a series of piperidones 1–8 by the Mannich reaction and analysis of their structures and conformations in solution by NMR and mass spectrometry. The six-membered rings in 2,4,6,8-tetraphenyl-3,7-diazabicyclo[3.3.1]nonan-9-ones, compounds 1 and 2, adopt a chair–boat conformation, while those in 2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9-ones, compounds 3–8, adopt a chair–chair conformation because of stereoelectronic effects. These stereoelectronic effects were analyzed by the 1 J C–H coupling constants, which were measured in the 13C satellites of the 1H NMR spectra obtained with the hetero-dqf pulse sequence. In the solid state, these stereoelectronic effects were investigated by measurement of X-ray diffraction data, the molecular geometry (torsional bond angles and bond distances), and inter- and intramolecular interactions, and by natural bond orbital analysis, which was performed using density functional theory at the ωB97XD/6311++G(d,p) level. We found that one of the main factors influencing the conformational stability of 3–8 is the interaction between the lone-pair electrons of nitrogen and the antibonding sigma orbital of C(7)–Heq (nN→σ*C–H(7)eq), a type of hyperconjugative interaction. PMID:26664617

  5. Embrace the challenge: advice for current and prospective department chairs.

    PubMed

    Sheldon, George F

    2013-07-01

    In this issue, Kastor discusses the challenges and responsibilities of a contemporary chair of medicine as described in interviews of 44 chairs. As a chair of surgery at the University of North Carolina at Chapel Hill for 17 years, the author of this commentary uses his own experiences to reflect on how the insights presented in Kastor's commentary can apply to department chairs in other specialties. Elements from Kastor's commentary, as well as additional observations from the author's tenure, may be sources of advice to future chairs of any department. The author concludes that, despite a changing health care environment and other significant leadership challenges, being a department chair is a rewarding job with many opportunities to pursue worthwhile objectives. PMID:23799438

  6. Structural, conformational, theoretical and pharmacological study of some amides derived from 3,7-dimethyl-9-[( N-substituted)-4-chlorobenzamido]3,7-diazabicyclo[3.3.1]nonane-9-carboxamide

    NASA Astrophysics Data System (ADS)

    Fernández, M. J.; Toledano, M. S.; Gálvez, E.; Orjales, A.; Berisa, A.; Labeaga, L.; Fonseca, I.; Sanz-Aparicio, J.; Bellanato, J.

    1995-06-01

    A series of 3,7-dimethyl-9-[( N-substituted)-4-chlorobenzamido]-3,7-diazabicyclo[3.3.1]nonane-9-carboxamides 1-3 have been synthesized and studied by infrared, Raman, 1H and 13C NMR spectroscopy and molecular modeling techniques. The crystal structure of 3,7-dimethyl-9-[( N-benzyl)-4-chlorobenzamido]-3,7-diazabicyclo[3.3.1]nonane-9-carboxamide ( 2) was determined by X-ray diffraction. In CDCl 3 and CD 3OD solutions, these compounds adopt a non-distorted chair-chair conformation with the N-substituents in an equatorial position. Compound 2 prevented acetic acid induced writhing in mice.

  7. Chair of a department of medicine: now a different job.

    PubMed

    Kastor, John A

    2013-07-01

    The job of chair of a department of medicine, once seen as the apex in the career of an academic internist, has lost much of its allure, in part because of increasing administrative and financial obligations that require more of the time and effort of chairs than formerly. This is the impression the author gathered from interviewing 44 current and former chairs, deans, division chiefs, and hospital directors.He was told that chairs have lost some of their independence as departments have become increasingly dependent on the support of the executives at their university hospitals who, as the source of funds and facilities, can even specify which clinical services the chairs may develop. Conflict over the assignment of resources between dean and hospital CEO, which one interviewee stated can produce "incredible tensions," can complicate efforts of chairs to build clinical and research strength within their departments according to their own preferences. The growing administrative and financial duties of the job have forced some chairs to decrease their dedication to the classic responsibilities of teaching medical students and house officers.Recruiting outstanding leaders for departments of medicine challenges search committees and deans more than in the past because many suitable candidates do not choose to be considered and prefer to lead institutes, centers, or specialty divisions. The author suggests, however, that schools-by providing chairs with adequate administrative support and authority-can structure the job to improve its attractiveness and allow chairs more time to engage in traditional academic pursuits. PMID:23799437

  8. Career development resource: educational leadership in a department of surgery: vice chairs for education.

    PubMed

    Sanfey, Hilary; Boehler, Margaret; DaRosa, Debra; Dunnington, Gary L

    2012-07-01

    The growing appreciation of the need to adopt an evidence-based approach to teaching and assessment has led to a demand for faculty who are well versed in best practices in education. Surgeons with interest and expertise in instruction, curriculum development, educational research, and evaluation can have an important impact on the educational mission of a department of surgery. The increased fervor for accountability in education together with the challenges imposed by accreditation agencies and hospitals has made educational leadership responsibilities more time consuming and complex. In response to this, an increasing number of department chairs created Vice Chair for Education positions to support clerkship and program directors and ensure the department's education mission statement is fulfilled. PMID:22704712

  9. A Qualitative Study of Faculty Members' Views of Women Chairs

    PubMed Central

    Isaac, Carol; Griffin, Lindsay

    2010-01-01

    Abstract Background Concurrent with the evolving role of the department chair in academic medicine is the entry of women physicians into chair positions. Because implicit biases that stereotypically masculine behaviors are required for effective leadership remain strong, examining faculty members' perceptions of their chair's leadership in medical school departments with women chairs can provide insight into the views of women leaders in academic medicine and the complex ways in which gender may impact these chairs' leadership style and actions. Methods We conducted semistructured interviews with 13 male and 15 female faculty members representing all faculty tracks in three clinical departments chaired by women. Inductive, qualitative analysis of the subsequent text allowed themes to emerge across interviews. Results Four themes emerged regarding departmental leadership. One dealt with the leadership of the previous chair. The other three described the current chair's characteristics (tough, direct, and transparent), her use of communal actions to help support and mentor her faculty, and her ability to build power through consensus. Because all three chairs were early in their tenure, a wait and see attitude was frequently expressed. Faculty generally viewed having a woman chair as an indication of positive change, with potential individual and institutional advantages. Conclusions This exploratory study suggests that the culture of academic medicine has moved beyond questioning women physicians' competence to lead once they are in top organizational leadership positions. The findings are also consonant with experimental research indicating that women leaders are most successful when they pair stereotypic male (agentic) behaviors with stereotypic female (communal) behaviors. All three chairs exhibited features of a transformational leadership style and characteristics deemed essential for effective leadership in academic medicine. PMID:20156081

  10. Evaluating Department Chair and Student Leadership in Higher Education

    ERIC Educational Resources Information Center

    Thurston, Linda P.; Middendorf, B. Jan

    2009-01-01

    In higher education, assessment of leadership capacities and performance of department chairs and students allows stakeholders to evaluate individuals and programs. To that end, this article describes the Individual Development and Educational Assessment (IDEA) Feedback for Department Chairs system, a psychometrically sound instrument developed…

  11. The Hot Seat: Profiling the Marketing Department Chair

    ERIC Educational Resources Information Center

    Aggarwal, Praveen; Rochford, Linda; Vaidyanathan, Rajiv

    2009-01-01

    The chair of the marketing department serves a critical role in balancing the needs of the university with those of the faculty. Because most department chairs are drawn from the faculty in their departments, the administrative role they take on conflicts with their desire to maintain their academic roles as teacher and researcher. Although there…

  12. The Strategic Value of Succession Planning for Department Chairs.

    PubMed

    Rayburn, William; Grigsby, Kevin; Brubaker, Linda

    2016-04-01

    Most faculty who aspire to be department chairs are unaware of succession processes at their institution. This Commentary highlights the importance of succession planning, emphasizing the general need for transparency. Succession planning provides institutional leaders the opportunity to optimize, renew, and revitalize their organization by ensuring successful leadership transitions. In contrast to leadership pathways in the military, corporate business, and hospital administration, planned succession of medical school department chairs has received little attention. Different approaches to succession planning are essential for emergency and planned transitions. Emergency succession plans should be in place at all times, regularly revisited, and modified as needed. Department chairs should begin considering their planned succession between one and five years after their initial appointment. The succession discussion between a chair and medical school dean requires cautious, thoughtful, and open discussions. Intradepartmental annual faculty performance evaluations permit the chair to mentor potential successors in acquiring future-oriented, institution-based leadership qualities necessary to be considered for a future department chair position. If health and time permit, the successful chair should remain in his or her current position until a successor is named or, preferably, is in place. Appointment of an interim chair as part of succession planning can be useful for on-the-job training of an internal candidate, yet awkwardness might ensue if there is more than one internal candidate.Succession development offers the great advantage of maintaining smooth organizational performance while optimizing talent management and exploring opportunities for transitioning individuals into leadership roles. PMID:26556290

  13. Promoting Excellent Teaching: The Chair as Academic Leader.

    ERIC Educational Resources Information Center

    Lamb, Bill

    Community college department chairs have many diverse responsibilities. One role which needs to be given more emphasis is that of "promoting excellent teaching." The three conditions which must be present for a department chair to begin promoting excellent teaching are open, honest, and positive communication; the ability to provide immediate…

  14. Effective Communication for Academic Chairs. SUNY Series in Speech Communication.

    ERIC Educational Resources Information Center

    Hickson, Mark, III, Ed.; Stacks, Don W.

    This book presents 11 contributed papers which examine communication aspects of the department chair position in academia. It is noted that most academic department chairs are not trained in management skills, including communication strategies. After an introductory chapter by Christopher H. Spicer and Ann Q. Staton, the following papers are…

  15. The Future Competencies of Department Chairs: A Human Resources Perspective

    ERIC Educational Resources Information Center

    Jones, Faye R.

    2011-01-01

    This exploratory study of department chairs, deans, and faculty at extensive research public universities in Florida resulted in the identification of 85 future competencies of department chairs using a human resources perspective. Results include a discussion of the top 20 most important competencies and the top 20 competencies anticipated to be…

  16. Turnover of First-Time Chairs in Departments of Psychiatry

    ERIC Educational Resources Information Center

    Buckley, Peter F.; Rayburn, William F.

    2011-01-01

    Objective: The authors examine the tenure of first-time Chairs in academic departments of psychiatry in order to stimulate discussion on extant workforce and leadership issues. Method: Data on tenure of Chairs in psychiatry and other nonsurgical specialties were derived from the longitudinal database of the Association of American Medical Colleges…

  17. X-ray and 1H-NMR spectroscopic studies of the structures and conformations of the new nootropic agents RU-35929, RU-47010 and RU-35965

    NASA Astrophysics Data System (ADS)

    Amato, Maria E.; Bandoli, Giuliano; Casellato, Umberto; Pappalardo, Giuseppe C.; Toja, Emilio

    1990-10-01

    The crystal and molecular structures of the nootropics (±)1-benzenesulphonyl-2-oxo-5-ethoxypyrrolidine ( 1), (±)1-(3-pyridinylsulphonyl)-2-oxo-5-ethoxypyrrolidine ( 2) and (±)1-benzenesulphonyl-2-oxo-5-isopropyloxypyrrolidine ( 3) have been determined by X-ray analysis. The solution conformation of 1, 2 and 3 has been investigated by 1H NMR spectroscopy. In the solid state, the main feature consists of the similar structural parameters and conformations, with the exception of the conformation adopted by the 5-ethoxy moiety which changes on passing from 1 to 2. The solid state overall enveloped conformation of the 2-pyrrolidinone ring for the three nootropics is found to be retained in solution on the basis of NMR evidence. Comparison between calculated and experimental coupling constant values shows that one of the two possible puckered opposite conformational isomers (half-chair shapes) occurs in solution. The relative pharmacological potencies of 1, 2 and 3 cannot therefore be interpreted in terms of the different conformation features presently detectable by available experimental methods.

  18. Electromyography comparison of normal chair-desk system and assistant chair-desk system on fatigue.

    PubMed

    Kwon, Moon-Seok; Lee, Sang-Ho; Cho, Ik-Rae; Won, Yu-Mi; Han, Mi-Kyung; Jung, Kon-Nym; Lee, Jae-Hee; Chin, Ji-Hyoung; Rho, Jae-Hun; Kim, Ju-Yeon; Yang, Jae-Bong; No, Jae-Kui; Park, Tae-Geun; Lee, Taek-Kyun; Park, Hyo-Joo; Lee, Sam-Jun; Yoo, Kyoung-Seok; Kang, Suh-Jung; Kwon, Se-Jeong; Shin, Mi-Ae; Kim, Hu-Nyun; Kahn, Hyung-Sik; Kim, Min-Jung; Kim, Tae-Young

    2015-10-01

    [Purpose] This study was designed to test the effects of the Assistant Chair-Desk System (ACDS), which can reduce the forward tilt of the neck and trunk and the level of fatigue during long lasting study in the sitting position. [Subjects] Fourteen middle school students and 14 college students of mixed gender participated in this study. [Methods] Fatigue level, the trapezius muscle, and the forward tilt angle of the head and trunk as well as distance factors were assessed before after using a normal chair-desk system (NCDS) and the ACDS for 120 minutes. [Results] There was an interaction effect in the angle and length of the neck from the sitting posture changes after 2 hours of studying using the NCDS and ACDS. There were also significant differences in the fatigue levels, hip joint angles and the lengths from the head according to the main effects of the chair-systems. [Conclusion] The studying position while using the ACDS was determined to prevent significant fatigue levels of the muscle and body, provide support to the head, by limiting the forward movement of the neck, and prevent forward tilt of the neck and trunk, by enabling the target point and gaze to be closer to the horizontal direction. PMID:26644668

  19. Electromyography comparison of normal chair-desk system and assistant chair-desk system on fatigue

    PubMed Central

    Kwon, Moon-Seok; Lee, Sang-Ho; Cho, Ik-Rae; Won, Yu-Mi; Han, Mi-Kyung; Jung, Kon-Nym; Lee, Jae-Hee; Chin, Ji-Hyoung; Rho, Jae-Hun; Kim, Ju-Yeon; Yang, Jae-Bong; No, Jae-Kui; Park, Tae-Geun; Lee, Taek-Kyun; Park, Hyo-Joo; Lee, Sam-Jun; Yoo, Kyoung-Seok; Kang, Suh-Jung; Kwon, Se-Jeong; Shin, Mi-Ae; Kim, Hu-Nyun; Kahn, Hyung-Sik; Kim, Min-Jung; Kim, Tae-Young

    2015-01-01

    [Purpose] This study was designed to test the effects of the Assistant Chair-Desk System (ACDS), which can reduce the forward tilt of the neck and trunk and the level of fatigue during long lasting study in the sitting position. [Subjects] Fourteen middle school students and 14 college students of mixed gender participated in this study. [Methods] Fatigue level, the trapezius muscle, and the forward tilt angle of the head and trunk as well as distance factors were assessed before after using a normal chair-desk system (NCDS) and the ACDS for 120 minutes. [Results] There was an interaction effect in the angle and length of the neck from the sitting posture changes after 2 hours of studying using the NCDS and ACDS. There were also significant differences in the fatigue levels, hip joint angles and the lengths from the head according to the main effects of the chair-systems. [Conclusion] The studying position while using the ACDS was determined to prevent significant fatigue levels of the muscle and body, provide support to the head, by limiting the forward movement of the neck, and prevent forward tilt of the neck and trunk, by enabling the target point and gaze to be closer to the horizontal direction. PMID:26644668

  20. Burnout in United States Academic Chairs of Radiation Oncology Programs

    SciTech Connect

    Kusano, Aaron S.; Thomas, Charles R.; DeWeese, Theodore L.; Formenti, Silvia C.; Hahn, Stephen M.; Lawrence, Theodore S.; Mittal, Bharat B.

    2014-02-01

    Purpose: The aims of this study were to determine the self-reported prevalence of burnout in chairs of academic radiation oncology departments, to identify factors contributing to burnout, and to compare the prevalence of burnout with that seen in other academic chair groups. Methods and Materials: An anonymous online survey was administered to the membership of the Society of Chairs of Academic Radiation Oncology Programs (SCAROP). Burnout was measured with the Maslach Burnout Inventory-Human Services Survey (MBI-HSS). Results: Questionnaires were returned from 66 of 87 chairs (76% response rate). Seventy-nine percent of respondents reported satisfaction with their current positions. Common major stressors were budget deficits and human resource issues. One-quarter of chairs reported that it was at least moderately likely that they would step down in the next 1 to 2 years; these individuals demonstrated significantly higher emotional exhaustion. Twenty-five percent of respondents met the MBI-HSS criteria for low burnout, 75% for moderate burnout, and none for high burnout. Group MBI-HSS subscale scores demonstrated a pattern of moderate emotional exhaustion, low depersonalization, and moderate personal accomplishment, comparing favorably with other specialties. Conclusions: This is the first study of burnout in radiation oncology chairs with a high response rate and using a validated psychometric tool. Radiation oncology chairs share similar major stressors to other chair groups, but they demonstrate relatively high job satisfaction and lower burnout. Emotional exhaustion may contribute to the anticipated turnover in coming years. Further efforts addressing individual and institutional factors associated with burnout may improve the relationship with work of chairs and other department members.

  1. Conformational analysis of 9β,19-cyclopropyl sterols: Detection of the pseudoplanar conformer by nuclear Overhauser effects and its functional implications

    PubMed Central

    Nes, W. David; Benson, Mabry; Lundin, Robert E.; Le, Phu H.

    1988-01-01

    Nuclear Overhauser difference spectroscopy and variable temperature studies of the 9β,19-cyclopropyl sterols 24,25-dehydropollinastanol (4,4-desmethyl-5α-cycloart-24-en-3β-ol) and cyclolaudenol [(24S)-24-methyl-5α-cycloart-25(27)-en-3β-ol] have shown the solution conformation of the B/C rings to be twist-chair/twist-boat rather than boat/chair as suggested in the literature. This is very similar to the known crystal structure conformation of 9β,19-cyclopropyl sterols. The effect of these conformations on the molecular shape is highly significant: the first conformation orients into a pseudoplanar or flat shape analogous to lanosterol, whereas the latter conformation exhibits a bent shape. The results are interpreted to imply that, for conformational reasons, cyclopropyl sterols can be expected to maintain the pseudoplanar shape in membrane bilayers. PMID:16593969

  2. Cyclo-biphenalenyl biradicaloid molecular materials: conformation, rearrangement, magnetism, and thermochromism

    SciTech Connect

    Huang, Jingsong; Sumpter, Bobby G; Meunier, Vincent; Tian, Yong-Hui; Kertesz, Prof. Miklos

    2010-01-01

    Cyclo-biphenalenyl biradicaloid molecular materials with chair- and boat-conformations are studied by restricted and broken-symmetry DFT using the M06 family of meta-GGA functionals. The global minima of these molecular materials are magnetically silent due to the sigma-bond connecting the two phenalenyls, while the sigma-bond may undergo low-barrier sigmatropic rearrangements via pi-pi bonded paramagnetic intermediates. The validation of theory is performed for the chair-conformation by comparing the sigma-bonded structures and the rearrangement barriers with experimental data. The boat-conformation is then studied using the validated functional. The electronic spectra of both chair- and boat-conformations are calculated and their applications in thermochromism are discussed.

  3. "Piekara's Chair": Mechanical Model for Atomic Energy Levels.

    ERIC Educational Resources Information Center

    Golab-Meyer, Zofia

    1991-01-01

    Uses the teaching method of models or analogies, specifically the model called "Piekara's chair," to show how teaching classical mechanics can familiarize students with the notion of energy levels in atomic physics. (MDH)

  4. 32. DETAIL OF BOARD ROOM CHAIR WITH SILVER PLATE LISTING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. DETAIL OF BOARD ROOM CHAIR WITH SILVER PLATE LISTING NAMES AND DATES OF PAST OCCUPANTS AND PLATE WITH NAME OF CURRENT OCCUPANT - Philadelphia Saving Fund Society, Twelfth & Market Streets, Philadelphia, Philadelphia County, PA

  5. Remaking the Graduate Curriculum: The Chair as Pragmatic Reformer.

    ERIC Educational Resources Information Center

    Ide, Richard S.

    1992-01-01

    Describes a practical approach to curricular revision from the point of view of a English department chair who presided over the remaking of the graduate curriculum and the hiring of new faculty. (RS)

  6. 82. REGENTS' ROOM WEST WALL, WITH ORIGINAL CHAIRS BY JAMES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    82. REGENTS' ROOM WEST WALL, WITH ORIGINAL CHAIRS BY JAMES RENWICK, JR. MANTELPIECE AND MIRROR ARE NOT ORIGINAL TO THE ROOM. - Smithsonian Institution Building, 1000 Jefferson Drive, between Ninth & Twelfth Streets, Southwest, Washington, District of Columbia, DC

  7. Integrating Mathematics with Problem Solving Using the Mathematician's Chair.

    ERIC Educational Resources Information Center

    Hildebrand, Charlene; Ludeman, Clinton J.; Mullin, Joan

    1999-01-01

    Describes an action-research study conducted in a third-grade classroom that integrates mathematical problem solving with the writing process through the use of the Mathematician's Chair. Contains 14 references. (ASK)

  8. [Immersion in a bath despite a safety bath chair].

    PubMed

    Christensen, H B; Lange, A

    1989-01-01

    A case of submersion is described. A mother left her child aged 8 1/2 months sitting in a "safety bath chair" in a full bath and found the child lying under the water shortly afterwards. The infant was hypotonic for a brief period but rapidly recovered without sequelae. Use of a "safety bath chair" gives a false sense of security and its use is warned against. PMID:2911907

  9. Ergonomic surgeon's chair for use during minimally invasive surgery.

    PubMed

    Schurr, M O; Buess, G F; Wieth, F; Saile, H J; Botsch, M

    1999-08-01

    The characteristic working situation in laparoscopic surgery involves elongated instruments and limited mobility of the surgeon during the operation. These circumstances require new technical solutions to enhance the surgeon's comfort. In other surgical fields with special ergonomic situations, such as microsurgery, some surgeons prefer to operate from a seated position at the operating room table. We developed a new surgeon's chair dedicated to the ergonomic and functional requirements of laparoscopic surgery. The chair allows the surgeon to maintain a semi-standing position during the operation. Foot pedals for high frequency and suction/irrigation are integrated into the base of the chair. The pedals are purposely aligned to be comparable to foot pedals in a car. The chair is driven by electromotors, controlled with a special foot switch that operates independent of assisting personnel during surgery. Initial clinical testing of the chair could prove the theory that supporting the surgeon with a cockpit type of operating room chair helps to avoid fatigue during long endoscopic procedures. Such assistance is especially important in combination with robotic devices for use during solo surgery. PMID:10871169

  10. Synthesis, structural, conformational and pharmacological study of some amides derived from 3 -methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9α-amine

    NASA Astrophysics Data System (ADS)

    Iriepa, I.; Bellanato, J.; Gálvez, E.; Gil-Alberdi, B.

    2010-07-01

    Some mono-substituted amides ( 2- 5) derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9α-amine were synthesized and studied by IR, 1H and 13C NMR spectroscopy. The crystal structure of 3-methyl-2,4-diphenyl-9α-(3,5-dichlorobenzamido)-3-azabicyclo[3.3.1]nonane ( 3) was determined by X-ray diffraction. NMR data showed that all compounds adopt in CDCl 3 a preferred flattened chair-chair conformation with the N-CH 3 group in equatorial disposition. X-ray data agreed with this conformation in the case of compound 3. IR data revealed that compounds 2 and 3 present a C dbnd O⋯HN intermolecular bond in the solid state. This conclusion was also confirmed by X-ray data of compound 3. In the case of compound 5, IR results suggested intermolecular NH⋯N-heterocyclic bonding. On the contrary, in the pyrazine derivative ( 4), IR, 1H and 13C NMR data showed the presence of an intramolecular NH⋯N1″-heterocyclic hydrogen bond in the solid state and solution. Moreover, NMR and IR data showed a preferred trans disposition for the NH-C dbnd O group. NMR also revealed free rotation of the -NH-CO-R group around C9-NH bond. Pharmacological assays on mice were drawn to evaluate analgesic activity.

  11. Substrate conformational transitions in the active site of chorismate mutase: Their role in the catalytic mechanism

    PubMed Central

    Guo, Hong; Cui, Qiang; Lipscomb, William N.; Karplus, Martin

    2001-01-01

    Chorismate mutase acts at the first branch-point of aromatic amino acid biosynthesis and catalyzes the conversion of chorismate to prephenate. The results of molecular dynamics simulations of the substrate in solution and in the active site of chorismate mutase are reported. Two nonreactive conformers of chorismate are found to be more stable than the reactive pseudodiaxial chair conformer in solution. It is shown by QM/MM molecular dynamics simulations, which take into account the motions of the enzyme, that when these inactive conformers are bound to the active site, they are rapidly converted to the reactive chair conformer. This result suggests that one contribution of the enzyme is to bind the more prevalent nonreactive conformers and transform them into the active form in a step before the chemical reaction. The motion of the reactive chair conformer in the active site calculated by using the QM/MM potential generates transient structures that are closer to the transition state than is the stable CHAIR conformer. PMID:11481470

  12. Influence of chair vibrations on indoor sonic boom annoyance

    NASA Astrophysics Data System (ADS)

    Rathsam, Jonathan; Klos, Jacob; Loubeau, Alexandra

    2015-10-01

    One goal of NASA's Commercial Supersonic Technology Project is to identify candidate noise metrics suitable for regulating quiet sonic boom aircraft. A suitable metric must consider the short duration and pronounced low frequency content of sonic booms. For indoor listeners, rattle and creaking sounds and floor and chair vibrations may also be important. The current study examined the effect of such vibrations on the annoyance of test subjects seated indoors. The study involved two chairs exposed to nearly identical acoustic levels: one placed directly on the floor, and the other isolated from floor vibrations by pneumatic elastomeric mounts. All subjects experienced both chairs, sitting in one chair for the first half of the experiment and the other chair for the remaining half. Each half of the experiment consisted of 80 impulsive noises played at the exterior of the sonic boom simulator. When all annoyance ratings were analyzed together there appeared to be no difference in mean annoyance with isolation condition. When the apparent effect of transfer bias was removed, a subtle but measurable effect of vibration on annoyance was identified.

  13. Influence of Chair Vibrations on Indoor Sonic Boom Annoyance

    NASA Technical Reports Server (NTRS)

    Rathsam, Jonathan; Klos, Jacob; Loubeau, Alexandra

    2015-01-01

    One goal of NASA’s Commercial Supersonic Technology Project is to identify candidate noise metrics suitable for regulating quiet sonic boom aircraft. A suitable metric must consider the short duration and pronounced low frequency content of sonic booms. For indoor listeners, rattle and creaking sounds and floor and chair vibrations may also be important. The current study examined the effect of such vibrations on the annoyance of test subjects seated indoors. The study involved two chairs exposed to nearly identical acoustic levels: one placed directly on the floor, and the other isolated from floor vibrations by pneumatic elastomeric mounts. All subjects experienced both chairs, sitting in one chair for the first half of the experiment and the other chair for the remaining half. Each half of the experiment consisted of 80 impulsive noises played at the exterior of the sonic boom simulator. When all annoyance ratings were analyzed together there appeared to be no difference in mean annoyance with isolation condition. When the apparent effect of transfer bias was removed, a subtle but measurable effect of vibration on annoyance was identified.

  14. Vapochromic Behavior of a Chair-Shaped Supramolecular Metallacycle with Ultra-Stability.

    PubMed

    Jiang, Bo; Zhang, Jing; Ma, Jian-Qiu; Zheng, Wei; Chen, Li-Jun; Sun, Bin; Li, Chao; Hu, Bing-Wen; Tan, Hongwei; Li, Xiaopeng; Yang, Hai-Bo

    2016-01-27

    A new discrete supramolecular metallacycle functionalized with an alkynylplatinum(II) bzimpy moiety was successfully prepared via coordination-driven self-assembly, and it displayed a reversible color change in the solid state between yellow and red, triggered by CH2Cl2 vapor or mechanical grinding. Notably, unlike many known vapochromic systems, the obtained vapochromic metallacycle exhibits ultra-stability, with the red color remaining unchanged in air for several months at room temperature or even under vacuum for >1 week. Further investigation revealed that the chair conformation of the metallacyclic scaffold, which was thought to prevent intermolecular steric repulsion between the alkyl chain and triethylphosphine, favored close molecular stacking through intermolecular Pt···Pt and π-π stacking interactions, thus allowing such vapochromic behavior with ultra-stability. PMID:26741405

  15. [Assessment of a hospital bath chair: an ergonomic approach].

    PubMed

    Comélio, Maria Estevam; Alexandre, Neusa Maria Costa

    2005-01-01

    A high rate of musculoskeletal disorders in members of the nursing team is observed in the literature. The use of special devices such as the bath chair has reduced the risk of back injuries in these workers and has also provided the patient with greater safety as well as comfort. The aim of the present study was to assess the ergonomic characteristics of a bath chair utilized in a hospital Separate questionnaires were applied for the nurses and the patients. The bath chair accessories presented several ergonomic problems. The perceived physical exertion according to the Borg-CR10 Scale indicated that a high level of exertion was required to manipulate the equipment (8.33). PMID:16514945

  16. 40 CFR 93.154 - Conformity analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Conformity analysis. 93.154 Section 93... General Federal Actions to State or Federal Implementation Plans § 93.154 Conformity analysis. Any Federal... choose to adopt the analysis of another Federal agency or develop its own analysis in order to make...

  17. 40 CFR 51.854 - Conformity analysis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Conformity analysis. 51.854 Section 51... Federal Actions to State or Federal Implementation Plans § 51.854 Conformity analysis. Link to an... for various aspects of a project, a Federal agency may choose to adopt the analysis of another...

  18. DFT studies of the conformation and relative energies of alpha-maltotetraose (DP-4): An amylose fragment at atomic resolution

    Technology Transfer Automated Retrieval System (TEKTRAN)

    DFT optimization studies of more than one hundred conformations of a-maltotetraose have been carried out at the B3LYP/6-311++G** level of theory. The DP-4 fragments of predominately 4C1 chair residues include tightly bent forms, helix, band-flips, kinks, boat, and some 1C4 conformers. The three do...

  19. Jaczko to resign as chair of Nuclear Regulatory Commission

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2012-05-01

    Gregory Jaczko, chair of the U.S. Nuclear Regulatory Commission (NRC), announced on 21 May that he will resign once his successor is appointed. His resignation will end a stormy 3-year chairmanship during which he was accused of bullying NRC staff, lying to Congress, and being too close to the political process. Jaczko formerly served as science advisor to Sen. Harry Reid (D-Nev.). As NRC chair, Jaczko halted the commission's license application review for storing nuclear waste at Nevada's Yucca Mountain. In addition, during his NRC tenure the commission focused on identifying and implementing lessons from Japan's Fukushima Daiichi reactors damaged by the 2011 tsunami.

  20. Strengthening Adoption Practice, Listening to Adoptive Families

    ERIC Educational Resources Information Center

    Atkinson, Anne; Gonet, Patricia

    2007-01-01

    In-depth interviews with 500 adoptive families who received postadoption services through Virginia's Adoptive Family Preservation (AFP) program paint a richly detailed picture of the challenges adoptive families face and what they need to sustain adoption for many years after finalization. Findings document the need for support in a variety of…

  1. Medical Issues in Adoption

    MedlinePlus

    ... to Know About Zika & Pregnancy Medical Issues in Adoption KidsHealth > For Parents > Medical Issues in Adoption Print ... or emotional abuse of the child continue Agency Adoptions If you adopt through an agency, you might ...

  2. Patients' choice of portable folding chairs to reduce symptoms of orthostatic hypotension

    NASA Technical Reports Server (NTRS)

    Smit, A. A.; Wieling, W.; Opfer-Gehrking, T. L.; van Emmerik-Levelt, H. M.; Low, P. A.

    1999-01-01

    Patients with neurogenic orthostatic hypotension may use portable folding chairs to prevent or reduce symptoms of low blood pressure. However, a concomitant movement disorder may limit the use of these chairs in daily living. In this prospective study, 13 patients with orthostatic hypotension, balance disturbance associated with motor disability, or both examined three commercially available portable folding chairs. A questionnaire was used to document the characteristics in chair design that were relevant for satisfactory use to these patients. Armrests, seat width, and an adjustable sitting height were found to be important features of a portable folding chair. One chair was selected by 11 of 13 patients to fit most needs.

  3. 21 CFR 890.3110 - Electric positioning chair.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Electric positioning chair. 890.3110 Section 890.3110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3110...

  4. 21 CFR 890.3110 - Electric positioning chair.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Electric positioning chair. 890.3110 Section 890.3110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3110...

  5. 21 CFR 890.3110 - Electric positioning chair.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Electric positioning chair. 890.3110 Section 890.3110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3110...

  6. 21 CFR 890.3110 - Electric positioning chair.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Electric positioning chair. 890.3110 Section 890.3110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3110...

  7. Competency Assessment and Human Resource Management of County Extension Chairs.

    ERIC Educational Resources Information Center

    Lindner, James R.

    The purpose of this descriptive and correlational study was to examine perceptions of Ohio State University Extension county chairs regarding their human resource management competencies and performance of human resource management activities. The study also sought to describe the relationship between human resource management competencies and…

  8. Strategies for establishing an endowed chair in a service setting.

    PubMed

    Randhawa, Simmy; Robinson, Nellie C; Feetham, Suzanne; Church, Tracy; Hinds, Pamela S; Talley, Linda B; Williams, Catherine

    2014-01-01

    To advance care for patients and families requires that providers and administrators in clinical settings place a high priority on the scientific domain of nursing. New knowledge intended to benefit nursing care is most effectively and efficiently achieved when a vibrant and well-supported nursing research program is embedded within a health care system. An endowed chair in nursing research is an esteemed strategy acknowledging the contributions of nursing science, providing credibility to a researcher and research programs, and demonstrating commitment to the infrastructure for nursing research. Organizational readiness through leadership; systems thinking; relationship development; and knowledge of the dynamics, process, and expectations of philanthropy are essential to establishing an endowed chair. Philanthropic endeavors can be used to strategically develop a high-impact campaign that resonates across public and private sectors to secure funding to solidify and advance nursing research. By actively engaging stakeholders including system leaders, frontline nurses, and other care providers and development leaders, a successful campaign can establish and sustain an endowed chair in nursing research. This article describes the stakeholders, processes, structure, and outcomes for the first endowed chair in nursing research at Children's National Health System in Washington, DC. PMID:25208148

  9. When Women Are Equal: The Canada Research Chair Experience

    ERIC Educational Resources Information Center

    Grant, Karen R.; Drakich, Janice

    2011-01-01

    This paper focuses on the gendered nature of elite academic careers. Of interest is how similar or different the experiences are of women and men who have been appointed to Canada Research Chairs (CRCs). In particular, we examine the impacts of holding a CRC position and consider the factors that shape that experience for women and men. Based on…

  10. 21 CFR 890.3110 - Electric positioning chair.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Electric positioning chair. 890.3110 Section 890.3110 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3110...

  11. Chairing and Caring: Gendered Dimensions of Leadership in Academe

    ERIC Educational Resources Information Center

    Acker, Sandra

    2012-01-01

    This article uses three frames of analysis, each with gendered implications, to interpret the author's narrative of experience as a department chair (head of department) in a Canadian university from 1999 to 2002. The narrative is based not only on memory but on transcripts of interviews conducted with the author at various points during her term…

  12. 30. LAUNCH CONTROL CAPSULE. ACOUSTICAL ENCLOSURE. OPERATORS' CHAIR AND COMMUNICATIONS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    30. LAUNCH CONTROL CAPSULE. ACOUSTICAL ENCLOSURE. OPERATORS' CHAIR AND COMMUNICATIONS CONSOLE IN FOREGROUND. ELECTRONIC EQUIPMENT RACK AT LEFT; LAUNCH CONTROL CONSOLE WITH CAPTAIN JAMES L. KING, JR. IN CENTER. LIEUTENANT KEVIN R. MCCLUNEY IN BACKGROUND. VIEW TO SOUTHEAST. - Minuteman III ICBM Launch Control Facility November-1, 1.5 miles North of New Raymer & State Highway 14, New Raymer, Weld County, CO

  13. Managing People: A Guide for Department Chairs and Deans.

    ERIC Educational Resources Information Center

    Leaming, Deryl R., Ed.

    This book is a collection of essays by experienced department chairs, deans, and vice-presidents. Each essay discusses a different aspect of people management in higher education, explaining the issues and offering suggestions and resources. The chapters are: (1) "Understanding Yourself" (Deryl R. Leaming); (2) "Understanding and Communicating…

  14. The analytic setting today: using the couch or the chair?

    PubMed

    Wiener, Jan

    2015-09-01

    This paper re-visits Murray Jackson's 1961 paper in the Journal of Analytical Psychology, 'Chair, couch and countertransference', with the aim of exploring the role of the couch for Jungian analysts in clinical practice today. Within the Society of Analytical Psychology (SAP) and some other London-based societies, there has been an evolution of practice from face-to-face sessions with the patient in the chair, as was Jung's preference, to a mode of practice where patients use the couch with the analyst sitting to the side rather than behind, as has been the tradition in psychoanalysis. Fordham was the founding member of the SAP and it was because of his liaison with psychoanalysis and psychoanalysts that this cultural shift came about. Using clinical examples, the author explores the couch/chair question in terms of her own practice and the internal setting as a structure in her mind. With reference to Bleger's (2013) paper 'Psychoanalysis of the psychoanalytic setting', the author discusses how the analytic setting, including use of the couch or the chair, can act as a silent container for the most primitive aspects of the patient's psyche which will only emerge in analysis when the setting changes or is breached. PMID:26274847

  15. Presidents and Chairs on Common Ground: Handling Flashpoints Together

    ERIC Educational Resources Information Center

    Fletcher, Donald H.; Maxwell, David E.

    2011-01-01

    In the face of public controversies, presidents and board chairs are often called upon to resolve difficult and divisive issues. When they are faced with public controversies and other challenges, a strong working relationship grounded in mutual respect and trust can make the difference between meeting the challenge head on and falling behind.…

  16. 7 CFR 1900.6 - Chair, Loan Resolution Task Force.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... under 7 CFR part 1951, subpart S; (b) The responsibility for making and directing the making of loan... servicing rights and pre-acceleration homestead and preservation loan servicing rights under 7 CFR part 1951... 7 Agriculture 12 2011-01-01 2011-01-01 false Chair, Loan Resolution Task Force. 1900.6...

  17. 7 CFR 1900.6 - Chair, Loan Resolution Task Force.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... under 7 CFR part 1951, subpart S; (b) The responsibility for making and directing the making of loan... servicing rights and pre-acceleration homestead and preservation loan servicing rights under 7 CFR part 1951... 7 Agriculture 12 2012-01-01 2012-01-01 false Chair, Loan Resolution Task Force. 1900.6...

  18. 7 CFR 1900.6 - Chair, Loan Resolution Task Force.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... under 7 CFR part 1951, subpart S; (b) The responsibility for making and directing the making of loan... servicing rights and pre-acceleration homestead and preservation loan servicing rights under 7 CFR part 1951... 7 Agriculture 12 2013-01-01 2013-01-01 false Chair, Loan Resolution Task Force. 1900.6...

  19. 7 CFR 1900.6 - Chair, Loan Resolution Task Force.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... under 7 CFR part 1951, subpart S; (b) The responsibility for making and directing the making of loan... servicing rights and pre-acceleration homestead and preservation loan servicing rights under 7 CFR part 1951... 7 Agriculture 12 2010-01-01 2010-01-01 false Chair, Loan Resolution Task Force. 1900.6...

  20. 7 CFR 1900.6 - Chair, Loan Resolution Task Force.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... primary servicing rights and pre-acceleration homestead and preservation loan servicing rights under 7 CFR... and pre-acceleration homestead and preservation loan servicing rights under 7 CFR part 1951, subpart S... 7 Agriculture 12 2014-01-01 2013-01-01 true Chair, Loan Resolution Task Force. 1900.6 Section...

  1. Chairs, Cars, and Bridges: Teaching Aesthetics from the Everyday

    ERIC Educational Resources Information Center

    Zande, Robin Vande

    2007-01-01

    It is very typical for students in K-12 art education to study aesthetics based on artistic objects. Artistic objects, however, need not be the sole source for aesthetic investigation. In this article, the author discusses the use of designed objects such as chairs, cars, and bridges in the discussion of aesthetic concepts. Students, as consumers…

  2. The Cost of Academic Leadership: Department Chair Stress.

    ERIC Educational Resources Information Center

    Gmelch, Walter H.; Burns, John S.

    1993-01-01

    A study of 564 college and university department heads investigated the most stressful situations, emergent themes, and differences between department chair and faculty stressors. Most stress came from heavy workload, time pressures, confrontations with colleagues, organizational constraints, and faculty duties. Faculty and administrative…

  3. 21 CFR 880.6140 - Medical chair and table.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Medical chair and table. 880.6140 Section 880.6140 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL HOSPITAL AND PERSONAL USE DEVICES General Hospital and Personal Use...

  4. Bourdieu, Department Chairs and the Reform of Science Education

    ERIC Educational Resources Information Center

    Melville, Wayne; Hardy, Ian; Bartley, Anthony

    2011-01-01

    Using the insights of the French sociologist, Pierre Bourdieu, this article considers the role of the science department chair in the reform of school science education. Using Bourdieu's "thinking tools" of "field", "habitus" and "capital", we case study the work of two teachers who both actively pursue the teaching and learning of science as…

  5. Human Research Program 2010 Chair Standing Review Panel Meeting

    NASA Technical Reports Server (NTRS)

    Steinberg, Susan

    2011-01-01

    The 13 Human Research Program (HRP) Standing Review Panel (SRP) Chairs, and in some cases one or two additional panel members (see section XIV, roster) referred to as the Chair (+1) SRP throughout this document, met at the NASA Johnson Space Center (JSC) on December 7, 2010 to allow the HRP Elements and Projects to report on their progress over the past year, their current status, and their plans for the upcoming year based on NASA's current goals and objectives for human space exploration. A large focus of the meeting was also used to discuss integration across the HRP scientific disciplines based on a recommendation from the 2009 HRP SRP review. During the one-day meeting, each of the HRP Elements and Projects presented the changes they made to the HRP Integrated Research Plan (IRP Rev. B) over the last year, and what their top three areas of integration are between other HRP Elements/Projects. The Chair (+1) SRP spent sufficient time addressing the panel charge, either as a group or in a separate closed session, and the Chair (+1) SRP and the HRP presenters and observers, in most cases, had sufficient time to discuss during and after the presentations. The SRP made a final debriefing to the HRP Program Scientist, Dr. John B. Charles, prior to the close of the meeting on December 7, 2010. Overall, the Chair (+1) SRP concluded that most of the HRP Elements/Projects did a commendable job during the past year in addressing integration across the HRP scientific disciplines with the available resources. The Chair (+1) SRP agreed that the idea of integration between HRP Elements/Projects is noble, but believes all parties involved should have the same definition of integration, in order to be successful. The Chair (+1) SRP also believes that a key to successful integration is communication among the HRP Elements/Projects which may present a challenge. The Chair (+1) SRP recommends that the HRP have a workshop on program integration (with HRP Element

  6. Conformational Landscape of Nicotinoids: Solving the "conformational - Rity" of Anabasine

    NASA Astrophysics Data System (ADS)

    Lesarri, Alberto; Cocinero, Emilio J.; Evangelisti, Luca; Suenram, Richard D.; Caminati, Walther; Grabow, Jens-Uwe

    2010-06-01

    The conformational landscape of the alkaloid anabasine (neonicotine) has been investigated using rotational spectroscopy and ab initio calculations. The results allow a detailed comparison of the structural properties of the prototype piperidinic and pyrrolidinic nicotinoids (anabasine vs. nicotine). Anabasine adopts two most stable conformations in isolation conditions, for which we determined accurate rotational and nuclear quadrupole coupling parameters. The preferred conformations are characterized by an equatorial pyridine moiety and additional N-H equatorial stereochemistry at the piperidine ring (Eq-Eq). The two rings of anabasine are close to a bisecting arrangement, with the observed conformations differing in a ca. 180° rotation of the pyridine subunit, denoted either Syn or Anti. The preference of anabasine for the Eq-Eq-Syn conformation has been established by relative intensity measurements (Syn/Anti˜5(2)). The conformational preferences of free anabasine are directed by a N\\cdot\\cdot\\cdotH-C weak hydrogen bond interaction between the nitrogen lone pair at piperidine and the closest hydrogen bond in pyridine, with N\\cdot\\cdot\\cdotN distances ranging from 4.750 Å (Syn) to 4.233 Å (Anti). R. J. Lavrich, R. D. Suenram, D. F. Plusquellic and S. Davis, 58^th OSU Int. Symp. on Mol. Spectrosc., Columbus, OH, 2003, Comm. RH13.

  7. Decision-Making Styles of Department Chairs at Public Jordanian Universities: A High-Expectancy Workforce

    ERIC Educational Resources Information Center

    Khasawneh, Samer; Alomari, Aiman; Abu-tineh, Abdullah

    2011-01-01

    The primary purpose of this study was to determine the decision-making styles of department chairs employed by three public institutions in Jordan. A total of 95 department chairs participated in the study by completing the General Decision-Making Styles survey. The results indicated that department chairs under study have the rational…

  8. Faculty Recruitment and Retention: A Case Study of the Chair's Role.

    ERIC Educational Resources Information Center

    Miller, Michael; Jackson, JoAnne C.; Pope, Myron L.

    This document states that many studies have identified faculty recruitment as a specific job responsibility of college department chairs. Because the recruitment process is time consuming and costly, the chair must also ensure that recruitment leads to retention. This paper closely examines what strategies academic chairs use to recruit and retain…

  9. The Role of the Academic Department Chair in ADA Student Accommodations.

    ERIC Educational Resources Information Center

    Morehouse, Percy A., Jr.; Becker, George; Combs, Lee

    The academic department chair has a pivotal role in the administration of special accommodations provided to students under the provisions of the Americans with Disabilities Act and Section 504 of the Rehabilitation Act of 1973. Department chairs may interact with all levels of the institution, and the interaction among chairs, the Equal…

  10. Department Chair Advice on Teaching and Research at U.S. Research Universities

    ERIC Educational Resources Information Center

    Taggart, Gabel

    2015-01-01

    Using data from a 2010 survey of academic chairs, this study reports on academic department chairs' recommended time allocations to new assistant professors. I contend that personal values about research and teaching influence the department chair's recommendations along with organizational characteristics. Multi-level modeling indicates that…

  11. The Internal Conflict Experienced by Public Community College Academic Department Chairs

    ERIC Educational Resources Information Center

    Johnson, Raymonda T.

    2010-01-01

    The focus of this research is the conflicted nature of the lived experience of public community college academic department chairs. In many colleges, department chairs are faculty chosen by colleagues and/or administration. Once selected, chairs assume supervisory responsibilities. The duality of this colleague-supervisor role has the potential…

  12. Transition into the Department Chair Role: The Manager-Leader Continuum

    ERIC Educational Resources Information Center

    Crowder, James

    2010-01-01

    The Department Chair position is perhaps the most important position on a college campus. Not only do Department Chairs have a large number of individual tasks to perform, but a Chair's actions have potentially large repercussions, since the bulk of the pedagogical and administrative decisions made at institutions of higher education are made at…

  13. An Interview With Chapman Conference Chair Venkat Lakshmi

    NASA Astrophysics Data System (ADS)

    McCarter-Joseph, Tricia

    2013-07-01

    AGU's Chapman Conference program has been facilitating small collaborative meetings on topical and specialized subjects for more than 35 years. These meetings allow for debate and an exploration of possible solutions to scientific problems, while providing a professional networking opportunity for younger scientists. Venkat Lakshmi, professor of hydrology, climate, and water resources and former chair of the Department of Earth and Ocean Sciences at the University of South Carolina, was selected in January as the Chapman Conference program chair through 2015. Lakshmi, a former Eos editor, recalls with enthusiasm organizing a 2012 Chapman Conference in Hawaii: the proposal writing, the grant writing, soliciting presenters, and gathering scientific material. He is now using his experience organizing meetings and mentoring students at his university to help advance the Chapman program. Eos spoke with him about his new role and his vision for the program.

  14. Adoption and Korea.

    ERIC Educational Resources Information Center

    Chun, Byung Hoon

    1989-01-01

    Because of Korean attitudes towards adoption and other reasons, attempts to promote intracountry adoption have met with limited success, and intercountry adoption is used as an alternative way of meeting children's needs. (RJC)

  15. Adopted Children and Discipline

    MedlinePlus

    ... a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care Communication & Discipline Types of Families Media ... Your Community Healthy Children > Family Life > Family Dynamics > Adoption & Foster Care > Adopted Children & Discipline Family Life Listen ...

  16. Adoption & Foster Care

    MedlinePlus

    ... Children > Family Life > Family Dynamics > Adoption & Foster Care Adoption & Foster Care Article Body ​Each year, many children join families through adoption and foster care. These families may face unique ...

  17. Roles, responsibilities, and outcome expectations of endowed chairs in nursing.

    PubMed

    Bushy, Angeline; Dunkin, Jeri W; Stover, Lynn

    2005-01-01

    This study, using a modified Delphi approach, examines the purpose, roles, responsibilities, and outcomes of endowed chairholders in nursing. Deans and faculty who hold endowed chairs participated in this 3-phased study. While the ranking of importance varied between these 2 groups of experts, common themes emerged relative to the phenomenon under investigation. Findings from this preliminary work can be used by deans and chairholders to develop job descriptions and evaluate the impact of endowments in a program of nursing. PMID:16030455

  18. Musical Chairs: An Innovative Teaching and Learning Method

    ERIC Educational Resources Information Center

    Kuo, Ya-Hui

    2010-01-01

    How teaching and learning takes place in classrooms can be easily seen by the way classrooms are set up: Students' desks and chairs are arranged in rolls while teachers' desks are up front. Yet, why must teachers be the ones who lecture, why can't it be students? Would it be better or worse when teachers are the receivers and the students are the…

  19. Analysis of sitting forces on stationary chairs for daily activities.

    PubMed

    Hu, Lingling; Tackett, Bob; Tor, Onder; Zhang, Jilei

    2016-04-01

    No literature related to the study of sitting forces on chairs sat on by people who weighed over 136 kg was found. The Business Institutional Furniture Manufactures Association needs force data for development of performance test standards to test chairs for users who weigh up to 181 kg. 20 participants who weighed from 136 to 186 kg completed 6 tasks on an instrumented chair in the sequence of sitting down, remaining seated and rising. Effects of sitting motion, armrest use and seat cushion thickness on vertical sitting forces and centre-of-force were investigated. Results indicated hard sitting down yielded the highest sitting force of 213% in terms of participants' body weights. Armrest use affected sitting forces of normal sitting down, but not of rising and hard sitting down. Cushion thickness affected sitting forces of normal and hard sitting down and shifting, but not of rising, static seating or stretching backward situations. Practitioner Summary: Results of the sitting force and centre-of-force data obtained for this research can help furniture manufacturers develop new product performance test standards for creating reliable engineering design and manufacturing quality and durable products to meet a niche market need. PMID:26257071

  20. Bourdieu, Department Chairs and the Reform of Science Education

    NASA Astrophysics Data System (ADS)

    Melville, Wayne; Hardy, Ian; Bartley, Anthony

    2011-11-01

    Using the insights of the French sociologist, Pierre Bourdieu, this article considers the role of the science department chair in the reform of school science education. Using Bourdieu's 'thinking tools' of 'field', 'habitus' and 'capital', we case study the work of two teachers who both actively pursue the teaching and learning of science as inquiry. One teacher, Dan, has been a department chair since 2000, and has actively encouraged his department to embrace science as inquiry. The other teacher, Leslie, worked for one year in Dan's department before being transferred to another school where science teaching continues to be more traditional. Our work suggests that there are three crucial considerations for chairs seeking to lead the reform of science teaching within their department. The first of these is the development of a reform-minded habitus, as this appears to be foundational to the capital that can be expended in the leadership of reform. The second is an understanding of how to wield power and position in the promotion of reform. The third is the capacity to operate simultaneously and strategically within, and across, two fields; the departmental field and the larger science education field. This involves downplaying administrative logics, and foregrounding more inquiry-focused logics as a vehicle to challenge traditional science-teaching dispositions-the latter being typically dominated by concerns about curriculum 'coverage'.

  1. Gradient and mc scf calculations of the conformers and the formation of primary ethylene ozonide

    NASA Astrophysics Data System (ADS)

    Ruoff, Peter; Sæbø, Svein; Almlöf, Jan

    1981-11-01

    The confonners of primary ethylene ozonide have been studied by ab initio gradient and MC SCF calculations. At the MC SCF level they are more spread in energy than in SCF calculations. The planar conformer, carbon-carbon half chair and the oxygen envelope are much higher m energy than the other conformers. The MC SCF activation energy for cyclo-addition of ozone and ethylene is 91-99 kJ/mole.

  2. AACP Strategy for Addressing the Professional Development Needs of Department Chairs

    PubMed Central

    Rodriguez, Tobias E.; Weinstein, George; Sorofman, Bernard A.; Bosso, John A.; Kerr, Robert A.; Haden, N. Karl

    2012-01-01

    Objectives. Characterize the skills and abilities required for department chairs, identify development needs, and then create AACP professional development programs for chairs. Methods. A 30-question electronic survey was sent to AACP member department chairs related to aspects of chairing an academic department. Results. The survey identified development needs in the leadership, management, and personal abilities required for effective performance as department chair. The information was used to prioritize topics for subsequent AACP development programs. Subsequent programs conducted at AACP Interim and Annual Meetings were well attended and generally received favorable reviews from participants. A list of development resources was placed on the AACP website. Conclusions. This ongoing initiative is part of an AACP strategy to identify and address the professional development needs of department chairs. Survey results may also inform faculty members and other academic leaders about the roles and responsibilities of department chairs. PMID:22919099

  3. Uncovering the Relationship between Sulphation Patterns and Conformation of Iduronic Acid in Heparan Sulphate

    NASA Astrophysics Data System (ADS)

    Hsieh, Po-Hung; Thieker, David F.; Guerrini, Marco; Woods, Robert J.; Liu, Jian

    2016-07-01

    The L-iduronic acid (IdoA) residue is a critically important structural component in heparan sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in 1C4-chair, 2SO-skew boat, and less frequently, in 4C1-chair conformations. Here, we analyzed the conformation of IdoA residue in eight hexasaccharides by NMR. The data demonstrate a correlation between the conformation of IdoA and sulphations in the surrounding saccharide residues. For the 2-O-sulpho IdoA residue, a high degree of sulphation on neighboring residues drives ring dynamics towards the 2SO-skew boat conformer. In contrast, the nonsulphated IdoA residue is pushed towards the 1C4-chair conformer when the neighboring residues are highly sulphated. Our data suggest that the conformation of IdoA is regulated by the sulphation pattern of nearby saccharides that is genetically controlled by the heparan sulphate biosynthetic pathway.

  4. Uncovering the Relationship between Sulphation Patterns and Conformation of Iduronic Acid in Heparan Sulphate

    PubMed Central

    Hsieh, Po-Hung; Thieker, David F.; Guerrini, Marco; Woods, Robert J.; Liu, Jian

    2016-01-01

    The L-iduronic acid (IdoA) residue is a critically important structural component in heparan sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in 1C4-chair, 2SO-skew boat, and less frequently, in 4C1-chair conformations. Here, we analyzed the conformation of IdoA residue in eight hexasaccharides by NMR. The data demonstrate a correlation between the conformation of IdoA and sulphations in the surrounding saccharide residues. For the 2-O-sulpho IdoA residue, a high degree of sulphation on neighboring residues drives ring dynamics towards the 2SO-skew boat conformer. In contrast, the nonsulphated IdoA residue is pushed towards the 1C4-chair conformer when the neighboring residues are highly sulphated. Our data suggest that the conformation of IdoA is regulated by the sulphation pattern of nearby saccharides that is genetically controlled by the heparan sulphate biosynthetic pathway. PMID:27412370

  5. Attitudinal Conformity and Anonymity

    ERIC Educational Resources Information Center

    Tyson, Herbert; Kaplowitz, Stan

    1977-01-01

    Tested college students for conformity when conditions contributing to conformity were absent. Found that social pressures (responding in public, being surveyed by fellow group members) are necessary to produce conformity. (RL)

  6. The Family of Adoption.

    ERIC Educational Resources Information Center

    Pavao, Joyce Maguire

    This book aims to provide a broad framework within which to think about adoption as a whole system, so that everyone involved will learn to feel some empathy for the other members of the adoption process. The book, written by a family and adoption therapist who was adopted as an infant, describes predictable developmental stages and challenges for…

  7. The Department Chair as Academic Leader. American Council on Education/Oryx Press Series on Higher Education.

    ERIC Educational Resources Information Center

    Hecht, Irene W. D.; Higgerson, Mary Lou; Gmelch, Walter H.; Tucker, Allan

    This book provides a comprehensive guide to the role of the academic department chair in a time when the chair's role is rapidly becoming more important and more complex. Part 1 describes the new roles chairs face, followed by a general discussion of their responsibilities. Part 2 is concerned with the department chair's work with people,…

  8. Shaking infant trauma induced by misuse of a baby chair.

    PubMed

    de San Lazaro, C; Harvey, R; Ogden, A

    2003-07-01

    A 2 month old infant presented with bilateral subdural haemorrhages and bilateral subhyaloid haemorrhage. The parent admitted to forceful bouncing of the child in a baby rocker. Experiments showed that violent rocking in the chair could produce extreme alternating acceleration/deceleration forces in excess of those induced by shaking alone. Such handling could not be interpreted as accidental mismanagement and the abusive nature of the process was graphically shown in video recordings of the experiment. Prosecution resulted in a conviction for cruelty, and a suspended sentence. PMID:12818916

  9. Conformational implications of asparagine-linked glycosylation.

    PubMed Central

    Imperiali, B; Rickert, K W

    1995-01-01

    The effects of cotranslational protein modification on the process of protein folding are poorly understood. Time-resolved fluorescence energy transfer has been used to assess the impact of glycosylation on the conformational dynamics of flexible oligopeptides. The peptide sequences examined are selected from glycoproteins of known three-dimensional structure. The energy transfer modulation associated with N-linked glycosylation is consistent with the glycopeptides sampling different conformational profiles in water. Results show that glycosylation causes the modified peptides to adopt a different ensemble of conformations, and for some peptides this change may lead to conformations that are more compact and better approximate the conformation of these peptides in the final folded protein. This result further implies that cotranslational glycosylation can trigger the timely formation of structural nucleation elements and thus assist in the complex process of protein folding. PMID:7816856

  10. Tabu search based strategies for conformational search.

    PubMed

    Stepanenko, Svetlana; Engels, Bernd

    2009-10-29

    This paper presents an application of the new nonlinear global optimization routine gradient only tabu search (GOTS) to conformational search problems. It is based on the tabu search strategy which tries to determine the global minimum of a function by the steepest descent-modest ascent strategy. The refinement of ranking procedure of the original GOTS method and the exploitation of simulated annealing elements are described, and the modifications of the GOTS algorithm necessary to adopt it to conformation searches are explained. The utility of the GOTS for conformational search problems is tested using various examples. PMID:19769347

  11. Tabu Search Based Strategies for Conformational Search

    NASA Astrophysics Data System (ADS)

    Stepanenko, Svetlana; Engels, Bernd

    2009-09-01

    This paper presents an application of the new nonlinear global optimization routine gradient only tabu search (GOTS) to conformational search problems. It is based on the tabu search strategy which tries to determine the global minimum of a function by the steepest descent-modest ascent strategy. The refinement of ranking procedure of the original GOTS method and the exploitation of simulated annealing elements are described, and the modifications of the GOTS algorithm necessary to adopt it to conformation searches are explained. The utility of the GOTS for conformational search problems is tested using various examples.

  12. Questions about Adoption

    MedlinePlus

    ... Español Text Size Email Print Share Questions About Adoption Page Content Article Body What's the best way to handle my child's questions about her adoption? Many parents want to know when is the ...

  13. What's Happening in Adoption?

    ERIC Educational Resources Information Center

    Gallagher, Ursula M.

    1975-01-01

    Reviews current issues in adoption: termination of parental rights, rights of unwed fathers, subsidized adoption, the recent influx of Vietnamese children, black market babies, agency accountability in placing children, the right of the adoptee to know his biological parents. (ED)

  14. A biomechanical and ergonomic evaluation of patient transferring tasks: wheelchair to shower chair and shower chair to wheelchair.

    PubMed

    Garg, A; Owen, B; Beller, D; Banaag, J

    1991-04-01

    A laboratory study was conducted to evaluate five different manual techniques (two-person manual lifting; rocking and pulling the patient using a gait belt with two persons; walking belt with one and two persons) and three different mechanical hoists (Hoyer lift, Trans-Aid and Ambulift) for transferring patients from wheelchair to shower chair and shower chair to wheelchair. Six female nursing students with prior patient transfer experience served both as nurses and as passive patients. Static biomechanical evaluation showed that the mean trunk flexion moments, erector spinae muscle forces and compressive and shear forces at the L5S1 disc for the four pulling methods ranged from 92 to 125 Nm, 1845 to 2507 N, 1973 to 2641 N and 442 to 580 N, respectively, as compared to about 213 Nm, 4260 N, 5050 N and 926 N for two-person manual lifting. Perceived stress ratings for the shoulder, upper back, lower back and whole body were significantly lower for pulling methods than those for lifting the patient (p less than or equal to 0.01). Patients found pulling techniques, except the gait belt, to be more comfortable and secure than the lifting method (p less than or equal to 0.01). However, most of the nurses believed that Medesign and the one-person walking belt would not work on those patients who cannot bear weight and those who are heavy, contracted or combative. A two-person walking belt was the most preferred method. Two out of three hoists (Hoyer lift and Trans-Aid) were perceived by the nurses to be more stressful than one- and two-person walking belts. The patients found these two hoists to be more uncomfortable and less secure than with three of the five manual methods (one- and two-person walking belts and Medesign). Pulling techniques and hoists took significantly longer amounts of time to make the transfer than manually lifting the patient (p less than or equal to 0.01). The two-person walking belt, using a gentle rocking motion to utilize momentum and a pulling

  15. Multidisciplinary approach to converting power chair into motorized prone cart.

    PubMed

    Brose, Steven W; Wali, Eisha

    2014-01-01

    Pressure ulcers remain a major source of morbidity and mortality in veterans with neurologic impairment. Management of pressure ulcers typically involves pressure relief over skin regions containing wounds, but this can lead to loss of mobility and independence when the wounds are located in regions that receive pressure from sitting. An innovative, low-cost, multidisciplinary effort was undertaken to maximize quality of life in a veteran with a thoracic-4 level complete spinal cord injury and a stage 4 ischial wound. The person's power wheelchair was converted into a motorized prone cart, allowing navigation of the Department of Veterans Affairs spinal cord injury hospital ward and improved socialization while relieving pressure on the wound. Physical and occupational therapy assisted with the reconfiguration of the power chair and verified safe transfers into the chair and driving of the device. Psychology verified positive psychosocial benefit, while nursing and physician services verified an absence of unwanted pain or skin injury resulting from use of the device. Further investigation of ways to apply this technique is warranted to improve the quality of life of persons with pressure ulcers. PMID:25786192

  16. Single Parent Adoptive Homes.

    ERIC Educational Resources Information Center

    Shireman, Joan F.

    1996-01-01

    Reviews research and reports on a longitudinal study of 15 single-parent adoptive homes over a 14-year period that demonstrated that these homes have the capacity to be successful adoptive placements. Identifies unique characteristics of single-parent adoptive homes, and notes the need for additional research to identify children for whom these…

  17. Adoption and Identity.

    ERIC Educational Resources Information Center

    Lieberman, E. James

    1998-01-01

    Discusses how adoption responds to ancient questions about origins. Maintains that one's identity hinges on actual relationships more than on pedigree and genes. Discusses reasons for informing a child about his or her adoption. Suggests that adoption is a constructive process involving too many worrisome warnings and anxiety-raising advice by the…

  18. The Effect of Family Communication Patterns on Adopted Adolescent Adjustment

    PubMed Central

    Rueter, Martha A.

    2008-01-01

    Adoption and family communication both affect adolescent adjustment. We proposed that adoption status and family communication interact such that adopted adolescents in families with certain communication patterns are at greater risk for adjustment problems. We tested this hypothesis using a community-based sample of 384 adoptive and 208 nonadoptive families. Adolescents in these families were, on average, 16 years of age. The results supported our hypothesis. Adopted adolescents were at significantly greater risk for adjustment problems compared to nonadopted adolescents in families that emphasized conformity orientation without conversation orientation and in families that emphasized neither conformity nor conversation orientation. Adolescents in families emphasizing conversation orientation were at lower risk for adjustment problems, regardless of adoption status. PMID:19649145

  19. A competency-based approach to recruiting, developing, and giving feedback to department chairs.

    PubMed

    Palmer, Megan; Hoffmann-Longtin, Krista; Walvoord, Emily; Bogdewic, Stephen P; Dankoski, Mary E

    2015-04-01

    Academic health centers (AHCs) are under unprecedented pressure, making strong leadership during these challenging times critical. Department chairs have tremendous influence in their AHCs, yet data indicate that--despite outstanding academic credentials--they are often underprepared to take on these important leadership roles. The authors sought to improve the approach to recruiting, developing, and giving feedback to department chairs at their institution, the Indiana University School of Medicine (IUSM), by reorganizing these processes around six key leadership competencies: leadership and team development, performance and talent management, vision and strategic planning, emotional intelligence, communication skills, and commitment to the tripartite mission. Over a two-year period (2009-2011), IUSM faculty and administrators developed standardized recruitment procedures to assess potential chairs based on the six leadership domains, and searches are now streamlined through centralized staff support in the dean's office. Additionally, IUSM offers a chair development series to support learning around these leadership competencies and to meet the stated professional development needs of the chairs. Finally, chairs receive structured feedback regarding their leadership (among other considerations) through two different assessment instruments, IUSM's Department Chair 360° Leadership Survey and IUSM's Faculty Vitality Survey--both of which the dean reviews annually. Strategically attending to the way that chairs are selected, developed, and given feedback has tremendous potential to increase the success of chairs and, in turn, to constructively shape the culture of AHCs. PMID:25607939

  20. Executive onboarding: ensuring the success of the newly hired department chair.

    PubMed

    Ross, Warren E; Huang, Karen H C; Jones, Greg H

    2014-05-01

    The success of newly recruited medical school department chairs has become increasingly important for achievement of organizational goals. An effective onboarding program for these chairs can greatly facilitate early success, as well as satisfaction of the new hire with the position and the school. Onboarding programs can include traditional orientation items such as payroll signup and parking details, but should focus heavily on sharing organizational structure, culture, and how things get done. The goals of onboarding will be well served by implementation of three roles in the process. An Orientation Navigator can assist the new chair in the orientation phase, completing new employee documents and navigating the day-to-day challenges of working at the location. A Peer Mentor, generally a sitting chair, serves as both "buddy" and mentor, providing moral support as well as ensuring that the new chair gains an understanding of the people and processes important for getting things done. A Transition Mentor serves over a longer term as a sounding board and coach outside the peer group, assisting in a variety of ways to promote the chair's growth, development, and success as a leader. Finally, any onboarding process is significantly compromised without the active participation of the dean, meeting regularly with the chair to clarify expectations, promote assimilation, and solve problems. Successful onboarding begins with a mindfulness of the needs of the newly hired chair, and a well-designed and well-implemented plan will have wide-ranging benefits for the chair and the organization. PMID:24667516

  1. The Transracial Adoption Paradox

    PubMed Central

    Lee, Richard M.

    2008-01-01

    The number of transracial adoptions in the United States, particularly international adoptions, is increasing annually. Counseling psychology as a profession, however, is a relatively silent voice in the research on and practice of transracial adoption. This article presents an overview of the history and research on transracial adoption to inform counseling psychologists of the set of racial and ethnic challenges and opportunities that transracial adoptive families face in everyday living. Particular attention is given to emergent theory and research on the cultural socialization process within these families. PMID:18458794

  2. Interpreting medium ring canonical conformers by a triangular plane tessellation of the macrocycle

    NASA Astrophysics Data System (ADS)

    Khalili, Pegah; Barnett, Christopher B.; Naidoo, Kevin J.

    2013-05-01

    Cyclic conformational coordinates are essential for the distinction of molecular ring conformers as the use of Cremer-Pople coordinates have illustrated for five- and six-membered rings. Here, by tessellating medium rings into triangular planes and using the relative angles made between triangular planes we are able to assign macrocyclic pucker conformations into canonical pucker conformers such as chairs, boats, etc. We show that the definition is straightforward compared with other methods popularly used for small rings and that it is computationally simple to implement for complex macrocyclic rings. These cyclic conformational coordinates directly couple to the motion of individual nodes of a ring. Therefore, they are useful for correlating the physical properties of macrocycles with their ring pucker and measuring the dynamic ring conformational behavior. We illustrate the triangular tessellation, assignment, and pucker analysis on 7- and 8-membered rings. Sets of canonical states are given for cycloheptane and cyclooctane that have been previously experimentally analysed.

  3. Rotational spectra of bicyclic decanes: the trans conformation of (-)-lupinine.

    PubMed

    Jahn, Michaela K; Dewald, David; Vallejo-López, Montserrat; Cocinero, Emilio J; Lesarri, Alberto; Grabow, Jens-Uwe

    2013-12-19

    The conformational and structural properties of the bicyclic quinolizidine alkaloid (-)-lupinine have been investigated in a supersonic jet expansion using microwave spectroscopy. The rotational spectrum is consistent with a single dominant trans conformation within a double-chair skeleton, which is stabilized by more than 10.4 kJ mol(-1) with respect to other conformations. In the isolated conditions of the jet, the hydroxy methyl side chain of the molecule locks in to form an intramolecular O-H···N hydrogen bond to the electron lone pair at the nitrogen atom. Accurate rotational constants, centrifugal distortion corrections, and (14)N nuclear quadrupole coupling parameters are reported and compared to ab initio (MP2) and DFT (M06-2X) calculations. The stability of lupinine is further compared computationally with epilupinine and decaline in order to gauge the influence of intramolecular hydrogen bonding, absent in these molecules. PMID:24028578

  4. Conformational readout of RNA by small ligands

    PubMed Central

    Kligun, Efrat; Mandel-Gutfreund, Yael

    2013-01-01

    RNA molecules have highly versatile structures that can fold into myriad conformations, providing many potential pockets for binding small molecules. The increasing number of available RNA structures, in complex with proteins, small ligands and in free form, enables the design of new therapeutically useful RNA-binding ligands. Here we studied RNA ligand complexes from 10 RNA groups extracted from the protein data bank (PDB), including adaptive and non-adaptive complexes. We analyzed the chemical, physical, structural and conformational properties of binding pockets around the ligand. Comparing the properties of ligand-binding pockets to the properties of computed pockets extracted from all available RNA structures and RNA-protein interfaces, revealed that ligand-binding pockets, mainly the adaptive pockets, are characterized by unique properties, specifically enriched in rare conformations of the nucleobase and the sugar pucker. Further, we demonstrate that nucleotides possessing the rare conformations are preferentially involved in direct interactions with the ligand. Overall, based on our comprehensive analysis of RNA-ligand complexes, we suggest that the unique conformations adopted by RNA nucleotides play an important role in RNA recognition by small ligands. We term the recognition of a binding site by a ligand via the unique RNA conformations “RNA conformational readout.” We propose that “conformational readout” is a general way by which RNA binding pockets are recognized and selected from an ensemble of different RNA states. PMID:23618839

  5. Fake conformal symmetry in conformal cosmological models

    NASA Astrophysics Data System (ADS)

    Jackiw, R.; Pi, So-Young

    2015-03-01

    We examine the local conformal invariance (Weyl invariance) in tensor-scalar theories used in recently proposed conformal cosmological models. We show that the Noether currents associated with Weyl invariance in these theories vanish. We assert that the corresponding Weyl symmetry does not have any dynamical role.

  6. Companion animal adoption study.

    PubMed

    Neidhart, Laura; Boyd, Renee

    2002-01-01

    To better understand the outcomes of companion animal adoptions, Bardsley & Neidhart Inc. conducted a series of 3 surveys over a 1-year period with dog and cat owners who had adopted their pet through either a (a) Luv-A-Pet location, (b) Adopt-a-thon, or (c) traditional shelter. This article suggests opportunities to improve owners' perceptions of their pets and the adoption process through (a) providing more information before adoption about pet health and behaviors, (b) providing counseling to potential adopters to place pets appropriately, and (c) educating adopters to promote companion animal health and retention. Results demonstrate that the pet's relationship to the family unit, such as where the pet sleeps and how much time is spent with the pet, is related to the amount of veterinary care the companion animal receives, and to long-term retention. Satisfaction and retention are attributed to the pet's personality, compatibility, and behavior, rather than demographic differences among adopters or between adoption settings. The age of the companion animal at adoption, the intended recipient, and presence of children in the home also play a role. Health problems were an issue initially for half of all adopted pets, but most were resolved within 12 months. Roughly one fourth of adopters who no longer have their companion animal said their pet died. Characteristics of pets that died support the contention that spaying and neutering profoundly affects a companion animal's life span. Although retention is similar for dogs and cats, mortality is higher among cats in the first year after adoption. PMID:12578739

  7. Does Your Annual Financial Report Conform?

    ERIC Educational Resources Information Center

    Foster, Charles W.

    1977-01-01

    Requirements for consideration of the Certificate of Conformance award sponsored by the Association of School Business Officials to encourage school districts to adopt and use generally accepted accounting and reporting principles for all funds used in the financial management of the school systems. (Author/MLF)

  8. American style or Turkish chair: the triumph of bodily comfort.

    PubMed

    Çevik, Gülen

    2010-01-01

    This article investigates the reciprocal influence of Ottoman Turkish and American interiors in the development of seating furniture. Seating furniture is unique because it involves a direct and physical interaction between the piece of furniture and the body, while at the same time it is part of a public space where social interactions occur. I will argue that the interactions between the Ottoman Turks and Americans are reflected in the way these traditions modified their seating furniture as they sought to mediate cultural, political and social differences between them. The concept of bodily comfort will serve as a common thread in understanding the origin of the expression "American style" (Amerikan stili or Amerikan tarzı) in modern Turkish language, the "Turkish chairs" in Victorian America in the late nineteenth century and the English language use of words such as sofa, ottoman and divan. PMID:21114093

  9. Human Vestibular Function, Rotating Litter Chair - Skylab Experiment M131

    NASA Technical Reports Server (NTRS)

    1970-01-01

    This 1970 photograph shows the Rotating Litter Chair, a major component of Skylab's Human Vestibular Function experiment (M131). The experiment was a set of medical studies designed to determine the effect of long-duration space missions on astronauts' coordination abilities. The M131 experiment tested the astronauts susceptibility to motion sickness in the Skylab environment, acquired data fundamental to an understanding of the functions of human gravity reception under prolonged absence of gravity, and tested for changes in the sensitivity of the semicircular canals. Data from this experiment was collected before, during, and after flight. The Marshall Space Flight Center had program management responsibility for the development of Skylab hardware and experiments.

  10. Airline Chair-rest Deconditioning: Induction of Immobilization Thromboemboli?

    NASA Technical Reports Server (NTRS)

    Greenleaf, J. E.; Rehrer, N. J.; Mohler, S. R.; Quach, D. T.; Evans, D. G.; Dalton, Bonnie P. (Technical Monitor)

    2002-01-01

    Air passenger miles will likely double by year 2020. The altered and restrictive environment in an airliner cabin can influence hematological homeostasis in passengers and crew. Flight-related deep various thromboemboli (DVT) have been associated with at least 577 deaths on 42 of 120 airlines from 1977 to 1984 (25 deaths/million departures), whereas many such cases go unreported. However, there are four major factors that could influence formation of possible flight-induced DVT: sleeping accomodations (via sitting immobilization), travelers' medical history (via tissue injury), cabin environmental factors (via lower partial pressure of oxygen and lower relative humidity), and the more encompassing chair-rest deconditioning (C-RD) syndrome. There is ample evidence that recent injury and surgery (especially in deconditioned hospitalized patients) facilitate thrombophlebitis and formation of DVT that may be exacerbated by the immobilization of prolonged air travel. In the healthy flying population immobilization factors associated with prolonged (> 5 hr) C-RID such as total body dehydration, hypovolemia and increased blood viscosity, and reduced various blood flow (pooling) in the legs may facilitate formation of DVT. However, data from at least four case-controlled epidemiological studies did not confirm a direct causative relationship between air travel and DART, but factors such as history of vascular thromboemboli, various insufficiency, chronic heart failure, obesity, immobile standing position, more than 3 pregnancies, infectious disease, long-distance travel, muscular trauma and violent physical effort were significantly more frequent in DVT patients than in controls. Thus, there is no clear, direct evidence yet that prolonged sitting in airliner seats, or prolonged experimental chair-rest- or bed- rest-deconditioning treatments cause deep various thromboemboli in healthy people.

  11. Airline chair-rest deconditioning: induction of immobilisation thromboemboli?

    NASA Technical Reports Server (NTRS)

    Greenleaf, John E.; Rehrer, Nancy J.; Mohler, Stanley R.; Quach, David T.; Evans, David G.

    2004-01-01

    Air passenger miles will likely double by year 2020. The altered and restrictive environment in an airliner cabin can influence haematological homeostasis in passengers and crew. Flight-related deep venous thromboemboli (DVT) have been associated with at least 577 deaths on 42 of 120 airlines from 1977 to 1984 (25 deaths/million departures), whereas many such cases go unreported. However, there are four major factors that could influence formation of possible flight-induced DVT: sleeping accommodations (via sitting immobilisation); travellers' medical history (via tissue injury); cabin environmental factors (via lower partial pressure of oxygen and lower relative humidity); and the more encompassing chair-rest deconditioning (C-RD) syndrome. There is ample evidence that recent injury and surgery (especially in deconditioned hospitalised patients) facilitate thrombophlebitis and formation of DVT that may be exacerbated by the immobilisation of prolonged air travel.In the healthy flying population, immobilisation factors associated with prolonged (>5 hours) C-RD such as total body dehydration, hypovolaemia and increased blood viscosity, and reduced venous blood flow (pooling) in the legs may facilitate formation of DVT. However, data from at least four case-controlled epidemiological studies did not confirm a direct causative relationship between air travel and DVT, but factors such as a history of vascular thromboemboli, venous insufficiency, chronic heart failure, obesity, immobile standing position, more than three pregnancies, infectious disease, long-distance travel, muscular trauma and violent physical effort were significantly more frequent in DVT patients than in controls. Thus, there is no clear, direct evidence yet that prolonged sitting in airliner seats, or prolonged experimental chair-rest or bed-rest deconditioning treatments cause DVT in healthy people.

  12. Report of the 10(th) Asia-Pacific Federation of Societies for Surgery of the Hand Congress (Organising Chair and Scientific Chair).

    PubMed

    A, Roohi Sharifah; Abdullah, Shalimar

    2016-10-01

    A report on the 10(th) Asia-Pacific Federation of Societies for the Surgery of the Hand and 6(th) Asia-Pacific Federation of Societies for Hand Therapists is submitted detailing the numbers of attendees participating, papers presented and support received as well the some of the challenges faced and how best to overcome them from the local conference chair and scientific chair point of view. PMID:27595972

  13. A Factor-Analytic Investigation of Role Types and Profiles of Higher Education Department Chairs.

    ERIC Educational Resources Information Center

    Carroll, James B.; Gmelch, Walter H.

    This paper reports on a study that investigated the role, attitudes, and behaviors of department chairs in higher education. Specifically, the study investigated four objectives: (1) to examine role factors of effective chair performance; (2) to assess the impact of antecedent variables such as individual characteristics (gender, marital status,…

  14. Preparing Department Chairs for Their Leadership Roles. New Directions for Community Colleges, Number 105.

    ERIC Educational Resources Information Center

    Gillet-Karam, Rosemary, Ed.

    1999-01-01

    This issue focuses on preparing department chairs for their leadership roles. It presents qualities that experienced chairs cite as being crucial to success, and asserts the need to develop formal training programs for people newly appointed to these positions. Articles include: (1) "Midlevel Management in the Community College: A Rose Garden?"…

  15. Stress Factors, Role Conflict, and Role Ambiguity for Academic Department Chairs.

    ERIC Educational Resources Information Center

    Burns, John S.; Gmelch, Walter H.

    This investigation examined the dimensional sources and perceptions of occupational stress experienced by department chairs in institutions of higher education, and the influence of professional independent variables associated with these stressors. Surveys were mailed to 800 randomly selected department chairs at 100 institutions (523 surveys…

  16. Influence of Web-Based Distance Education on the Academic Department Chair Role

    ERIC Educational Resources Information Center

    Franklin, Kathy K.; Hart, Jan K.

    2006-01-01

    The purpose of this study was to examine academic department chair perceptions about the future influence of web-based distance education on departmental operations and their changing role as academic leader. Using a rating, modified-policy Delphi method, the researcher worked with 22 department chairs employed at public, urban universities in the…

  17. Leadership Experiences and Characteristics of Chairs of Academic Departments of Psychiatry

    ERIC Educational Resources Information Center

    Keith, Samuel J.; Buckley, Peter F.

    2011-01-01

    Objective: Effective leadership in academic medicine requires a broad constellation of skills, experiences, and core values. The authors sought to describe and define these. Method: The authors conducted a web-based survey among 132 Chairs of North American departments of psychiatry. Results: Eighty-five Chairs (64%) responded to the survey, the…

  18. 20 CFR 661.320 - Who must chair a Local Board?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Who must chair a Local Board? 661.320 Section... Governance Provisions § 661.320 Who must chair a Local Board? The Local Board must elect a chairperson from among the business representatives on the board. (WIA sec. 117(b)(5).)...

  19. The Community College Department Chair and Curriculum Leadership: Managing Learning and Learning to Manage

    ERIC Educational Resources Information Center

    Sweeney, Kathleen Jennings

    2012-01-01

    Dwindling resources, the challenges of providing postsecondary remedial education, and an environment that emphasizes outcomes assessment are realities that confront the community college department chair. The role of the department chair is particularly challenging in the community college context due to accountability pressures, fiscal…

  20. Dimensions of Leadership among Community College Health Career Program Department Chairs and Implications for Leadership Development

    ERIC Educational Resources Information Center

    Platz-Wiechert, Lynn Marie

    2010-01-01

    Given the growth in community colleges, the projected need for health career workers, and the central position of the department chair in higher education, this study explored dimensions of leadership as identified by health career department chairs in five Illinois community colleges. Areas of study included: (a) professional profiles of health…

  1. The Chair and the New President: Getting the First Months Right

    ERIC Educational Resources Information Center

    Riggs, Janet Morgan; Duelks, Robert

    2012-01-01

    Gettysburg College President Janet Morgan Riggs and Board Chair Robert N. Duelks are both members of the Gettysburg class of 1977, but did not know each other as students. As a member of the college's board of trustees, Duelks chaired the presidential search committee that selected Riggs as Gettysburg's 14th president in 2009. Then, one year after…

  2. The Body Language Behaviours of the Chairs of the Disputes According to the Disputants

    ERIC Educational Resources Information Center

    Caliskan, Nihat

    2009-01-01

    The perception form of the body language behaviours of the session chairs by disputants affects the efficiency of the process. Therefore, it is important to determine the effects of the mimic, gesture, physical appearance and tonality and accent of the chairs on disputants. That research was conducted to clarify how the disputants perceive the…

  3. Cultivating Possibilities: Prospective Department Chair Professional Development and Why It Matters

    ERIC Educational Resources Information Center

    Wolverton, Mimi; Ackerman, Robert

    2006-01-01

    Faculty who are selected to be academic department chairs generally lack leadership preparation and have little understanding of the demands of the position. Good experiences as a faculty member do not necessarily translate to being a good department chair. As strategic planning becomes increasingly essential to the well being of colleges and…

  4. King among Kings: Understanding the Role and Responsibilities of the Department Chair in Higher Education

    ERIC Educational Resources Information Center

    Berdrow, Iris

    2010-01-01

    The role and responsibilities of the chair of an academic department in higher education is considered from the perspective of both actor and agent, within the context of the institution being served and the department being represented. The intent of this article is to further research on the role of department chair by analyzing it in the…

  5. 21 CFR 878.4950 - Manual operating table and accessories and manual operating chair and accessories.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Manual operating table and accessories and manual... Surgical Devices § 878.4950 Manual operating table and accessories and manual operating chair and accessories. (a) Identification. A manual operating table and accessories and a manual operating chair...

  6. Roles, Responsibilities, Challenges, and Rewards: The Lived Experience of ESL Department Chairs in Community Colleges

    ERIC Educational Resources Information Center

    Lam, Chin

    2014-01-01

    This study addresses the lived experience of ESL department chairs in California community colleges. It adds to existing literature that aims to support these individuals who are serving in critical roles in institutions of higher education. Using phenomenological methods, four ESL department chairs were interviewed to explore their journeys…

  7. Chair Perceptions of Trust between Mentor and Mentee in Online Doctoral Dissertation Mentoring

    ERIC Educational Resources Information Center

    Rademaker, Linnea L.; Duffy, Jennifer O'Connor; Wetzler, Elizabeth; Zaikina-Montgomery, Helen

    2016-01-01

    We explored online dissertation chairs' perceptions of trust in the mentor-mentee relationship, as trust was identified as a crucial factor in the success of doctoral students. Through the implementation of a multiple-case study, and a qualitative, online questionnaire, and through qualitative data analysis, we discovered 16 chairs' perceptions of…

  8. 76 FR 20651 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Environmental Management Site-Specific Advisory Board Chairs (76 FR 17118). This notice announces the... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of cancellation of open meeting. SUMMARY: On March 28, 2011, in FR Doc. 2011-7243, on page 17118, the...

  9. Toward Focusing Conformational Ensembles on Bioactive Conformations: A Molecular Mechanics/Quantum Mechanics Study.

    PubMed

    Avgy-David, Hannah H; Senderowitz, Hanoch

    2015-10-26

    The identification of bound conformations, namely, conformations adopted by ligands when binding their target is critical for target-based and ligand-based drug design. Bound conformations could be obtained computationally from unbound conformational ensembles generated by conformational search tools. However, these tools also generate many nonrelevant conformations thus requiring a focusing mechanism. To identify such a mechanism, this work focuses on a comparison of energies and structural properties of bound and unbound conformations for a set of FDA approved drugs whose complexes are available in the PDB. Unbound conformational ensembles were initially obtained with three force fields. These were merged, clustered, and reminimized using the same force fields and four QM methods. Bound conformations of all ligands were represented by their crystal structures or by approximations to these structures. Energy differences were calculated between global minima of the unbound state or the Boltzmann averaged energies of the unbound ensemble and the approximated bound conformations. Ligand conformations which resemble the X-ray conformation (RMSD < 1.0 Å) were obtained in 91%-97% and 96%-98% of the cases using the ensembles generated by the individual force fields and the reminimized ensembles, respectively, yet only in 52%-56% (original ensembles) and 47%-65% (reminimized ensembles) as global energy minima. The energy window within which the different methods identified the bound conformation (approximated by its closest local energy minimum) was found to be at 4-6 kcal/mol with respect to the global minimum and marginally lower with respect to a Boltzmann averaged energy of the unbound ensemble. Better approximations to the bound conformation obtained with a constrained minimization using the crystallographic B-factors or with a newly developed Knee Point Detection (KPD) method gave lower values (2-5 kcal/mol). Overall, QM methods gave lower energy differences than

  10. Associations between Family Communication Patterns, Sibling Closeness, and Adoptive Status

    PubMed Central

    Samek, Diana R.; Rueter, Martha A.

    2011-01-01

    Previous research has demonstrated the protective effect of family and sibling closeness on child adjustment, but fewer studies have investigated how closeness is promoted within families. Guided by Family Communication Patterns Theory, we tested the association between family communication and sibling emotional and behavioral closeness, and whether adoptive status moderated this relationship. Participating families included 616 adoptive and non-adoptive families with two adolescent children. Hypotheses were tested using structural equation modeling. Sibling closeness was highest in families that emphasized both conversation and conformity and lowest in families that emphasized only conversation or neither conversation nor conformity. Emotional and behavioral closeness were differentially associated with adoption status, sibling age, and sibling gender. Few moderating effects of adoption status were found. Post hoc analyses showed moderating effects of sibling gender composition. PMID:21984844

  11. Single Parent Adoption.

    ERIC Educational Resources Information Center

    Administration for Children, Youth, and Families (DHHS), Washington, DC.

    Presenting two views of the single-parent family, this pamphlet includes an article by two researchers (William Feigelman and Arnold R. Silverman) and a short statement by a single adoptive parent (Amanda Richards). The first paper summarizes earlier research on single-parent adoptions and discusses the results of a nationwide survey of 713…

  12. DOE Chair of Excellence Professorship in Environmental Disciplines

    SciTech Connect

    Shoou-Yuh Chang

    2013-01-31

    The United States (US) nuclear weapons program during the Cold War left a legacy of radioactive, hazardous, chemical wastes and facilities that may seriously harm the environment and people even today. Widespread public concern about the environmental pollution has created an extraordinary demand for the treatment and disposal of wastes in a manner to protect the public health and safety. The pollution abatement and environmental protection require an understanding of technical, regulatory, economic, permitting, institutional, and public policy issues. Scientists and engineers have a major role in this national effort to clean our environment, especially in developing alternative solutions and evaluation criteria and designing the necessary facilities to implement the solutions. The objective of the DOE Chair of Excellence project is to develop a high quality educational and research program in environmental engineering at North Carolina A&T State University (A&T). This project aims to increase the number of graduate and undergraduate students trained in environmental areas while developing a faculty concentrated in environmental education and research. Although A&T had a well developed environmental program prior to the Massie Chair grant, A&T's goal is to become a model of excellence in environmental engineering through the program's support. The program will provide a catalyst to enhance collaboration of faculty and students among various engineering departments to work together in a focus research area. The collaboration will be expanded to other programs at A&T. The past research focus areas include: hazardous and radioactive waste treatment and disposal fate and transport of hazardous chemicals in the environment innovative technologies for hazardous waste site remediation pollution prevention Starting from 2005, the new research focus was in the improvement of accuracy for radioactive contaminant transport models by ensemble based data assimilation. The

  13. Low Profile, High Impact: Four Case Studies of High School Department Chairs Whose Transactions "Transform" Teachers and Administrators.

    ERIC Educational Resources Information Center

    Wettersten, Jill A.

    This paper explores the leadership strategies of four exemplary high school department chairs. It develops a model based on social-exchange theory to show how chairs, as middle managers, must satisfy the expectations of both teachers and administrators. Data were derived from a case study of department chairs identified as exemplary in four…

  14. 75 FR 44767 - Folding Metal Tables and Chairs From the People's Republic of China: Initiation of New Shipper...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... Chairs From the People's Republic of China, 67 FR 43277 (June 27, 2002). On June 30, 2010, we received a... International Trade Administration Folding Metal Tables and Chairs From the People's Republic of China... metal tables and chairs (``FMTCs'') from the People's Republic of China (``PRC''), received on June...

  15. Voices of Women in the Field: The Top 10 Things We Learned about Being a Department Chair

    ERIC Educational Resources Information Center

    Danielson, Lana; Schulte, Laura

    2007-01-01

    This article documents the top 10 things we learned in our transition from being a faculty member to becoming a department chair. We were recruited as department chairs in the same year and quickly recognized each other as administrative colleagues. During our "internship" in the chair position we frequently identified lessons we were learning,…

  16. The Department Chair: Professional Development and Role Conflict. AAHE-ERIC/Higher Education Research Report No. 10, 1982.

    ERIC Educational Resources Information Center

    Booth, David B.

    The role of the department chair as the interface between faculty and administration is considered, along with the selection, orientation, socialization, and evaluation of the chair. Attention is directed to constraints under which chairs work that are beyond their control and the way that the resulting conflict, overload, and ambiguity impede…

  17. What does your chair know about your stress level?

    PubMed

    Arnrich, Bert; Setz, Cornelia; La Marca, Roberto; Tröster, Gerhard; Ehlert, Ulrike

    2010-03-01

    The inferred cost of work-related stress call for early prevention strategies. In this, we see a new opportunity for affective and pervasive computing by detecting early warning signs. This paper goes one step toward this goal. A collective of 33 subjects underwent a laboratory stress intervention, while a set of physiological signals was collected. In this paper, we investigate whether affective information related to stress can be found in the posture channel during office work. Following more recent work in this field, we directly associate features that are derived from the pressure distribution on a chair with affective states. We found that nervous subjects reveal higher variance of movements under stress. Furthermore, we show that a person-independent discrimination of stress from cognitive load is feasible when using pressure data only. A supervised variant of a self-organizing map, which is able to adapt to different patterns of stress responses, reaches an overall accuracy of 73.75% with unknown subjects. PMID:19887325

  18. A chair with a platform setup to measure the forces under each thigh when sitting, rising from a chair and sitting down.

    PubMed

    Nadeau, S; Desjardins, P; Brière, A; Roy, G; Gravel, D

    2008-03-01

    This paper describes the design, technical characteristics and first results of an adjustable instrumented chair with a sitting surface that records the forces under each thigh. The seat includes a force platform assembly suitable for measuring the magnitude, position and direction of the force applied to each thigh while sitting or rising from the chair. The natural frequency of the chair fixed to the floor was found to be 14.0 +/- 2 Hz with an estimated damping of xi = 0.20. Static tests showed that the maximal errors were 2% of the full-scale output (726 N vertically, 164 N horizontally) for both vertical and horizontal forces. The root mean square error of the center of pressure location was estimated as 5 mm. Preliminary data on the net joint moment at the hips of one healthy subject computed with and without consideration for the forces under the thighs revealed significant amplitude differences. In conclusion, the results indicate that the characteristics of the instrumented chair are acceptable and the chair can be used to assess the biomechanics of sitting and sit-to-stand and stand-to-sit tasks in various subject populations. PMID:18193467

  19. Parenting Your Adopted Teenager

    MedlinePlus

    ... https: / / www. childwelfare. gov/ pubs/ f- openadopt/ .) The Internet and the explosion of social media sites (e. ... 4 Howard, J. (2012). Untangling the web: The Internet’s transformative impact on adoption . New York, NY: Evan ...

  20. Adoption and Sibling Rivalry

    MedlinePlus

    ... child in your family should understand her own origins, and those of her brothers and sisters. But ... children can seem exaggerated because of their different origins. For instance, i f your adoptive child does ...

  1. Travelers' Health: International Adoption

    MedlinePlus

    ... preadoption living standards, varying disease epidemiology in the countries of origin, the presence of previously unidentified medical problems, and ... know the disease risks in the adopted child’s country of origin and the medical and social histories of the ...

  2. SU-C-19A-05: Treatment Chairs for Modern Radiation Therapy Treatments

    SciTech Connect

    Court, L; Fullen, D; Tharp, K; Palmer, J; Ungchusri, G; Reyes, L; Tong, T; Nguyen, S; Phillips, T; Balter, P

    2014-06-15

    Purpose: Treating patients in a seated position has potential advantages including improved comfort, increased lung volume, and reduced respiratory motion. We compared chair designs for head and neck, thoracic and breast patients for use with either IGRT linacs or a proposed low-cost fixed horizontal beam-line machine. Methods: Three treatment chairs were designed and constructed. Two of the chairs are based on a massage-chair, with the patient angled slightly forwards and knee rests used to minimize intra-fraction slouch. The third chair design is more conventional; the patient is angled backwards, with indexed positioning devices and the ability to attach thermoplastic masks. Patient geometries, including PTV location and patient sizes, were extracted from 137 CTs of past patients were used to model the probability of collision between the patient and the linac for various seated positions. All chairs were designed around the weight limits for couches on our linacs. At the time of writing we have just received IRB approval for imaging studies to evaluate comfort, and intra- and interfraction reproducibility. Results: The geometric analysis showed that head and neck patients and thoracic patients could be treated without collision. However, there is very limited space between the patient and the treatment/imaging devices, so careful design of the chair is essential. The position of the treatment target and extended arm positioning means that this is a particular concern for thoracic and breast patients. This was demonstrated for one of the prototype chairs designed for breast treatment where the arm holders would collide with the kV detector. The extra clearance of a dedicated fixed-beam linac would overcome these difficulties. Intra- and inter-fraction reproducibility results will be presented at the meeting. Conclusion: To take advantage of the clinical advantages of seated treatments, appropriate treatment chairs are needed. A dedicate fixed-beam linac may

  3. Design of the advanced commode-shower chair for spinal cord-injured individuals.

    PubMed

    Malassigné, P; Nelson, A L; Cors, M W; Amerson, T L

    2000-01-01

    The purpose of this development project was to design a new commode-shower chair that can be safely used by individuals with spinal cord injuries (SCI) and their caregivers. The need for this new design was consumer-driven. Patients and caregivers identified the following fatal flaws in the commode-shower chairs used in Spinal Cord Injury (SCI) centers: 1) risk for patient falls during transfers, propelling, and while leaning over for showering; 2) risk for pressure ulcers due to inadequate padding and seat positioning for lengthy bowel care regimes; 3) inadequate caregiver access to the perianal area of the patient to perform bowel care procedures; and, 4) wheel-related inability to properly position the chair directly over the toilet. The new, self-propelled chair addresses each of these concerns. Lockable, swing-away, pivoting armrests and improved, lever-activated brakes were designed to facilitate safe transfers. An innovative foot-lift was invented to facilitate washing of feet. Larger handrims were designed to aid in propulsion in wet environments. To prevent pressure ulcers, a chair frame and padding combination was designed to facilitate a seating position that optimally distributes body weight to prevent the development of pressure ulcers in the sacral and ischial areas. To address the common risk of heel ulcers, footrests, featuring edgeless, rounded heel cups, were designed. A new tubular chair frame, a new seat and smaller wheels were designed to enhance caregiver access and ensure proper chair positioning over the toilet. Following its successful clinical evaluation at the Milwaukee and Tampa VA Medical SCI Centers, the Advanced commode-shower chair is being patented by the Department of Veterans Affairs (VA). The VA has partnered with Everest & Jennings, to make this chair available commercially. PMID:10917269

  4. Conformational features of secondary N-cyclopropyl amides.

    PubMed

    González-de-Castro, Ángela; Broughton, Howard; Martínez-Pérez, José A; Espinosa, Juan F

    2015-04-17

    NMR studies in conjunction with ab initio calculations revealed unexpected conformational behavior of N-cyclopropylacetamide (1). This secondary amide displays 16-19% E-rotamer (cis) around the carbonyl-nitrogen bond in apolar solvents, in contrast to other aliphatic secondary acetamides in which significant E-rotamer populations are rare due to steric contacts between the substituents on the amide bond. In addition, 1 adopts an ortho conformation around the N-cPr bond instead of the anti conformation generally preferred by secondary acetamides. This distinct conformational behavior was also observed for other secondary N-cyclopropyl amides. PMID:25803271

  5. Conformational properties of bottle-brush polymers

    NASA Astrophysics Data System (ADS)

    Denesyuk, N. A.

    2003-05-01

    General and renormalized perturbation theories are used to study the conformational properties of a bottle-brush molecule, composed of multiarmed polymer stars grafted regularly onto a flexible backbone. The end-to-end distances of the backbone and of an arm of the middle star are calculated within the first order of perturbation theory. For the high grafting densities of stars, the calculated expressions are generalized with the help of the scaling arguments to give the equivalent power laws. According to these laws, the molecule may adopt a sequence of three different conformations (star-rod-coil) as the length of the backbone grows.

  6. Conformational properties of bottle-brush polymers.

    PubMed

    Denesyuk, N A

    2003-05-01

    General and renormalized perturbation theories are used to study the conformational properties of a bottle-brush molecule, composed of multiarmed polymer stars grafted regularly onto a flexible backbone. The end-to-end distances of the backbone and of an arm of the middle star are calculated within the first order of perturbation theory. For the high grafting densities of stars, the calculated expressions are generalized with the help of the scaling arguments to give the equivalent power laws. According to these laws, the molecule may adopt a sequence of three different conformations (star-rod-coil) as the length of the backbone grows. PMID:12786171

  7. Restraint chair with rowing-like movement for exposing exercising nonhuman primates to microwave irradiation

    SciTech Connect

    Knepton, J.; Ezell, C.; de Lorge, J.

    1983-04-20

    Design and construction of a Styrofoam exercise restraint chair is described for use with rhesus monkeys exposed to microwaves. Monkeys usually learn the rowing-like motion of the device within five 1-hour conditioning sessions. Radiation intensity measure of the chair and an example animal experiment demonstrated the chair's suitability for bioelectromagnetic studies. Results of a series of base-line behavioral sessions demonstrated concomitant exercise work load effects on colonic temperature, heart rate, correct response rate, and post-reinforcement pause time. With additional instrumentation, detection of minute disturbances of integrated psychological and physiological mechanisms by unusual environmental factors may be possible.

  8. 45 CFR 233.110 - Foster care maintenance and adoption assistance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 2 2012-10-01 2012-10-01 false Foster care maintenance and adoption assistance... maintenance and adoption assistance. (a) State plan requirements. A State plan under title IV-A of the Social... Security Act, and operates a foster care maintenance and adoption assistance program in conformity...

  9. 45 CFR 233.110 - Foster care maintenance and adoption assistance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 2 2011-10-01 2011-10-01 false Foster care maintenance and adoption assistance... maintenance and adoption assistance. (a) State plan requirements. A State plan under title IV-A of the Social... Security Act, and operates a foster care maintenance and adoption assistance program in conformity...

  10. 45 CFR 233.110 - Foster care maintenance and adoption assistance.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false Foster care maintenance and adoption assistance... maintenance and adoption assistance. (a) State plan requirements. A State plan under title IV-A of the Social... Security Act, and operates a foster care maintenance and adoption assistance program in conformity...

  11. 45 CFR 233.110 - Foster care maintenance and adoption assistance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 2 2014-10-01 2012-10-01 true Foster care maintenance and adoption assistance... maintenance and adoption assistance. (a) State plan requirements. A State plan under title IV-A of the Social... Security Act, and operates a foster care maintenance and adoption assistance program in conformity...

  12. 45 CFR 233.110 - Foster care maintenance and adoption assistance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 2 2013-10-01 2012-10-01 true Foster care maintenance and adoption assistance... maintenance and adoption assistance. (a) State plan requirements. A State plan under title IV-A of the Social... Security Act, and operates a foster care maintenance and adoption assistance program in conformity...

  13. Conformations of Low-Molecular-Weight Lignin Polymers in Water.

    PubMed

    Petridis, Loukas; Smith, Jeremy C

    2016-02-01

    Low-molecular-weight lignin binds to cellulose during the thermochemical pretreatment of biomass for biofuel production, which prevents the efficient hydrolysis of the cellulose to sugars. The binding properties of lignin are influenced strongly by the conformations it adopts. Here, we use molecular dynamics simulations in aqueous solution to investigate the dependence of the shape of lignin polymers on chain length and temperature. Lignin is found to adopt collapsed conformations in water at 300 and 500 K. However, at 300 K, a discontinuous transition is found in the shape of the polymer as a function of the chain length. Below a critical degree of polymerization, Nc =15, the polymer adopts less spherical conformations than above Nc. The transition disappears at high temperatures (500 K) at which only spherical shapes are adopted. An implication relevant to cellulosic biofuel production is that lignin will self-aggregate even at high pretreatment temperatures. PMID:26763657

  14. Galilean conformal electrodynamics

    NASA Astrophysics Data System (ADS)

    Bagchi, Arjun; Basu, Rudranil; Mehra, Aditya

    2014-11-01

    Maxwell's Electrodynamics admits two distinct Galilean limits called the Electric and Magnetic limits. We show that the equations of motion in both these limits are invariant under the Galilean Conformal Algebra in D = 4, thereby exhibiting non-relativistic conformal symmetries. Remarkably, the symmetries are infinite dimensional and thus Galilean Electrodynamics give us the first example of an infinitely extended Galilean Conformal Field Theory in D > 2. We examine details of the theory by looking at purely non-relativistic conformal methods and also use input from the limit of the relativistic theory.

  15. Conformational Isomerism Can Limit Antibody Catalysis

    SciTech Connect

    Debler, E.W.; Muller, R.; Hilvert, D.; Wilson, I.A.

    2009-05-14

    Ligand binding to enzymes and antibodies is often accompanied by protein conformational changes. Although such structural adjustments may be conducive to enzyme catalysis, much less is known about their effect on reactions promoted by engineered catalytic antibodies. Crystallographic and pre-steady state kinetic analyses of antibody 34E4, which efficiently promotes the conversion of benzisoxazoles to salicylonitriles, show that the resting catalyst adopts two interconverting active-site conformations, only one of which is competent to bind substrate. In the predominant isomer, the indole side chain of Trp{sup L91} occupies the binding site and blocks ligand access. Slow conformational isomerization of this residue, on the same time scale as catalytic turnover, creates a deep and narrow binding site that can accommodate substrate and promote proton transfer using Glu{sup H50} as a carboxylate base. Although 34E4 is among the best catalysts for the deprotonation of benzisoxazoles, its efficiency appears to be significantly limited by this conformational plasticity of its active site. Future efforts to improve this antibody might profitably focus on stabilizing the active conformation of the catalyst. Analogous strategies may also be relevant to other engineered proteins that are limited by an unfavorable conformational pre-equilibrium.

  16. Conformational analysis of menthol diastereomers by NMR and DFT computation

    NASA Astrophysics Data System (ADS)

    Härtner, Julia; Reinscheid, Uwe M.

    2008-01-01

    Correlations between experimental and calculated 13C chemical shifts were performed with the series of all menthol diastereomers. In this way it could be shown that identification problems with newly isolated natural products can be solved. Starting from simulated, low energy conformers of menthol, neomenthol, isomenthol, and neoisomenthol the 13C chemical shifts were obtained using DFT calculations [functional: B3LYP, basis set: 6-31G(d,p)]. Due to differences in chemical shifts, the prochiral methyl groups of the isopropyl substituent of menthol could be differentiated using the correlations between experimental and calculated values. A conformational scan of the dihedral angle of the isopropyl group allowed the determination of the dominating rotamers of menthol (+68.4°) and neomenthol (+172.5°) using 13C chemical shifts. The results were supported by energy calculations, 1JCH and 3JHH measurements. The correlations and 3JHH measurements for isomenthol indicate conformational averaging impeding the determination of the isopropyl group rotamer. For neoisomenthol, MD simulations showed two chair conformations. However, in contrast to calculated energies and correlations between theoretical and experimental 13C chemical shifts, the measured 3JH3H2 coupling of 6.3 Hz indicates an equally populated equilibrium of both conformers.

  17. Adolescents' Feelings about Openness in Adoption: Implications for Adoption Agencies

    ERIC Educational Resources Information Center

    Berge, Jerica M.; Mendenhall, Tai J.; Wrobel, Gretchen M.; Grotevant, Harold D.; McRoy, Ruth G.

    2006-01-01

    Adoption research commonly uses parents' reports of satisfaction when examining openness in adoption arrangements. This qualitative study aimed to fill a gap in the adoption research by using adolescents' voices to gain a better understanding of their adoption experiences. Adopted adolescents (n = 152) were interviewed concerning their…

  18. Samuel P. Massie Chair of Excellence in Environmental Disciplines

    SciTech Connect

    Adeyiga, Adeyinka A.

    2014-12-17

    The establishment of the DOE-EM Dr. Samuel P. Massie Chair of Excellence provides an excellent opportunity for Hampton University to be involved in key environmental issues in the 21st Century. The main areas of focus are on: 1. Coal gasification with respect to pollution prevention and reduction. 2. Solid waste treatment through bioremediation technology and 3. Industrial wastewater treatment Synthesizing ion catalysts suitable for use in slurry bubble column reaction was carried out. Construction of an autoclave continuous stirred tank reactor has been completed. At the initial stage of the development of this program, work was conducted in the area of formic acid recovery from waste streams, which yielded useful results. We also succeeded in the removal of priority metal ions such as cadmium, chromium, copper, lead, mercury, nickel, silver, thallium, zinc, etc., from industrial and municipal wastewater by using natural wastes. The process uses tree leaves to adsorb the metal ions in the wastewater. The ultimate goal is to develop inexpensive, highly available, effective metal ion adsorbents from natural wastes as an alternative to existing commercial adsorbents, and also to explain the possible adsorption mechanism that is taking place. This technology uses natural wastes to eliminate other wastes. Obviously, there are several advantages: (1) the negative impact on environment is eliminated, (2) the complicated regeneration step is not needed, and (3) the procedure saves money and energy. Twelve different types of leaves have been tested with lead, zinc, and nickel. The study mechanism showed that the leaf tannin is an active ingredient in the adsorption of metal ions. The ion-exchange mechanism controlled the adsorption process.

  19. The Green Chair: A Motivation for Teenagers To Replace Aggressive Behavior with Words.

    ERIC Educational Resources Information Center

    Lipetz, Laura

    2001-01-01

    Using a technique designed to channel students' aggressive behavior into constructive energy, students who intend to act out sit in a chair and say anything they want. This therapeutic talk reduces disruptive behavior. (SK)

  20. A President Interprets the Roles and Powers of the Ideal Chair.

    ERIC Educational Resources Information Center

    Dedmon, Donald N.

    1985-01-01

    Considers the department chair crucial to the welfare of the university, responsible for housekeeping functions (scheduling, planning, etc.), recruiting faculty and students, and assuming advisory/leadership roles in the campus community. (PD)

  1. Effect of beach chair position on bispectral index values during arthroscopic shoulder surgery

    PubMed Central

    Lee, Sang Wook; Choi, Soo Eun; Han, Jin Hee; Kang, Wha Ja; Choi, Young Kyoo

    2014-01-01

    Background Bispectral index (BIS) monitoring reduces the cases of intraoperative awareness. Several factors can alter BIS readings without affecting the depth of anesthesia. We conducted a study to assess the impact of beach chair position (sitting position) on BIS readings. Methods General anesthesia was administered to 30 patients undergoing arthroscopic shoulder surgery. Patients were kept in neutral position (supine) for 10 minutes and BIS readings, mean arterial blood pressure, heart rate, end-tidal carbon dioxide, and end-tidal sevoflurane were recorded. Patients were then shifted to beach chair position. After 15 minutes, data were recorded. Results A significant decrease in BIS values (P < 0.01) associated with a position change from neutral position to beach chair position was evident. Conclusions BIS values are significantly decreased in the beach chair position compared with the neutral position and might affect interpretation of the depth of anesthesia. PMID:25368780

  2. Comparison of seat pressures on three bowel care/shower chairs in spinal cord injury.

    PubMed

    Nelson, A L; Malassigné, P; Murray, J

    1994-12-01

    Pressure, positioning, and postural support are critical aspects in the design of a new bowel care/shower chair for persons with spinal cord injuries (SCI). The purpose of this evaluation was to evaluate seating pressures on three existing bowel care/shower chairs commonly used by persons with spinal cord injuries. A pressure mapping device, the Force Sensing Array, was used to measure seat pressure, position and postural support. Three seated subjects with spinal cord injuries were evaluated on each of the following three bowel care/shower chairs: Lumex, TRAUM-AID and E&J. The results of this evaluation will be briefly presented. This study is part of a larger study to design a bowel care/shower chair that uniquely meets the needs of persons with spinal cord injury. PMID:7777842

  3. The Trial: A Parable of a Department Chair before the Law of the Budget.

    ERIC Educational Resources Information Center

    Beja, Morris

    1994-01-01

    Discusses the seemingly contradictory nature of chairing an English department by highlighting the opposing impulses faced, especially as related to funding. Presents the situation in the form of a parable similar to a work by Franz Kafka. (HB)

  4. Access to the Heads and Chairs Program expands beyond AGU Fall Meeting

    NASA Astrophysics Data System (ADS)

    Asher, Pranoti M.; Keane, Christopher M.

    2012-09-01

    The AGU Education and Public Outreach department is pleased to announce a new collaboration with the American Geosciences Institute (AGI) for AGU's existing Heads and Chairs Program. This collaboration developed from a mutual interest in supporting the higher education departments of Earth and space sciences, as well as a desire to combine activities and resources toward strengthening that support. Through this partnership, AGI's Workforce Program and AGU's education staff are hosting hour-long webinars on various topics each month to engage department heads and chairs in discussions that will help them share, learn, and apply new ideas to their own programs. The ultimate goal is to provide opportunities for open dialogue beyond the annual Heads and Chairs workshops held at the AGU Fall Meeting each year, as well as to support those heads and chairs who are unable to attend Fall Meeting.

  5. Conformal bootstrap in embedding space

    NASA Astrophysics Data System (ADS)

    Fortin, Jean-François; Skiba, Witold

    2016-05-01

    It is shown how to obtain conformal blocks from embedding space with the help of the operator product expansion. The minimal conformal block originates from scalar exchange in a four-point correlation function of four scalars. All remaining conformal blocks are simple derivatives of the minimal conformal block. With the help of the orthogonality properties of the conformal blocks, the analytic conformal bootstrap can be implemented directly in embedding space, leading to a Jacobi-like definition of conformal field theories.

  6. Modeling and experiment reveal an unexpected stereoelectronic effect on conformation and scalar couplings of alpha-aminoorganostannanes, with possible relevance to the tin-lithium exchange reaction.

    PubMed

    Santiago, Marcelina; Low, Eddy; Chambournier, Gilles; Gawley, Robert E

    2003-10-31

    The solution conformation of N-methyl-2-(tributylstannyl)piperidines has been determined through the use of vicinal 119Sn-13C coupling constants, revealing a conformational distortion caused by an unexpected stereoelectronic effect in some cases. Specifically, the "equatorial" conformer is distorted into a half-chair, in which the nitrogen lone pair eclipses the C-Sn bond. This distortion, which "costs" approximately 1 kcal/mol, correlates with a conformational dependence of geminal 119Sn-15N couplings and a possible correlation with reactivity in the tin-lithium exchange reaction. PMID:14575474

  7. Managing osteoarthritis: comparisons of chair yoga, Reiki, and education (pilot study).

    PubMed

    Park, Juyoung; McCaffrey, Ruth; Dunn, Dorothy; Goodman, Rhonda

    2011-01-01

    The aim of this pilot study was to determine whether chair yoga and Reiki affect pain, depressive mood, and physical function compared with an educational program for older adults with osteoarthritis. Findings showed significant relationships only between physical function and chair yoga. In focus group interviews, participants expressed feelings of improved health and well-being after the yoga intervention. The major limitation of this study was the small sample size. PMID:22015342

  8. Conformations of Substituted Ethanes.

    ERIC Educational Resources Information Center

    Kingsbury, Charles A.

    1979-01-01

    Reviews state-of-the-art of conformational analysis and factors which affect it. Emphasizes sp-3 hybridized acrylic molecules. Provides examples on the importance of certain factors in determining conformation. Purpose, is to provide examples for examination questions. (Author/SA)

  9. Effect of Furniture Weight on Carrying, Lifting, and Turning of Chairs and Desks among Elementary School Children

    PubMed Central

    Funatsu, Kyotaro; Xiong, Jinghong; Rosyidi, Cucuk Nur

    2015-01-01

    Rearranging furniture in elementary school classrooms encourages classroom activities. In elementary schools in Indonesia and some other developing countries, usually only one style of furniture is used for all children, and the furniture is heavy and oversized for younger children. This affects their ability to carry it. The objective of this study is to investigate the effects of elementary school furniture weight and children’s age on performance of three carrying tasks (carrying a chair, lifting and turning a chair on a desk, and carrying both a chair and a desk together), from the ergonomics point of view. A total of 42 schoolchildren (ages 6–9; 17 Indonesian, 25 Japanese) participated in this study. Two types of Japanese chairs (Chair A and B, weight: 3.2 kg and 3.9 kg), one type of Indonesian chair (Chair C, weight: 5.0 kg), and two types of desks (height: 58 cm and 68 cm) were used. Indonesian chairs took significantly longer time to carry than the two Japanese chairs, and there was a significant negative relationship between age and task time for Chairs B and C, but not Chair A. Success rates for lifting and turning the chair declined as age decreased and chair weight increased, but were not significantly influenced by desk height. Success rates for carrying a chair and desk together significantly decreased with heavier furniture. Children aged six showed an extremely low success rate in almost all conditions. In conclusion, children’s ability to carry furniture is affected by their age and furniture characteristics, especially weight. In order to encourage classroom activities in elementary school, school furniture should be of appropriate weight. Supervision for younger children is required during classroom furniture arrangement. PMID:26053154

  10. Respiratory chest movement measurement as a chair quality indicator – preliminary observations

    PubMed Central

    Szczygieł, Elżbieta; Zielonka, Katarzyna; Mazur, Tadeusz; Mętel, Sylwia; Golec, Joanna

    2015-01-01

    Regardless of the constantly increasing time man is spending in a sitting position, there is still a lack of objective chair quality assessment criteria. The aim of this paper is to find the answer to whether respiratory chest movement measurements can be a chair quality indicator. The study included 34 participants (mean 34.7 years ± 5.2). Their chest movements were assessed using respiratory inductive plethysmography while sitting on two subsequent chairs. Significant differences in chest movements depending on chair type were observed concerning the breathing duct (upper and lower) and breathing movement amplitude. The amplitude of the upper respiratory track in the first chair was higher (239.4 mV) compared with the second seat (207.3 mV) (p = .018). The analyzed parameters of respiratory chest movement may become a helpful indicator for design and selection of chairs which enable people to both work and relax in the most ergonomic conditions. PMID:26323780

  11. Changes of Musculoskeletal Deformity in Severely Disabled Children Using the Custom Molded Fitting Chair

    PubMed Central

    Kim, Myeong Ok; Lee, Jun Ho; Yu, Ju Young; An, Pil Suk; Hur, Do Hang; Park, Eun Seo

    2013-01-01

    Objective To know the effectiveness of a custom molded fitting chair between pre- and post-chair status through comparison of musculoskeletal indices in severely disabled children. Methods We researched 34 severely disabled patients who had used a custom molded fitting chair continuously for more than a year. There were 27 cerebral palsy patients and 7 patients with other kinds of diseases that affect the brain such as chromosomal disease or metabolic disease. By radiographic studies, Cobb's angle, the femoral neck-shaft angle of the femur, and Reimers migration percentage were measured. The indices are analyzed before and after application. Results The average period of application was 24 months. There was a significant reduction in the angles of femur neck-shaft, 163.4 degree before and 158.2 degree after the use of the chair (p<0.05), and 23 of 34 had demonstrated a reduced angle. Cobb's angle and Reimers migration percentage increased but the difference of pre- and post-chair status was not statistically significant. Seventeen of 33 children showed reduced Cobb's angle. Also, 19 of 37 showed a reduced degree of dislocation of the hip joints. Conclusion In spite of the use of a custom molded fitting chair, a significant improvement did not emerge for musculoskeletal deformity indices in severely disabled children. However, there was no significant aggravation of Cobb's angle or Reimers migration percentage in developing children. Therefore, it is thought be helpful to prevent rapid aggravation of musculoskeletal deformities. PMID:23524955

  12. Toddler Adoption: The Weaver's Craft.

    ERIC Educational Resources Information Center

    Hopkins-Best, Mary

    Based on concern about the lack of information on adopting toddlers, this book examines the special needs of adopted toddlers and their adoptive parents. Chapter 1, "Why Write a Book on Toddler Adoption?" details the lack of information on the difficulties of adopted toddlers in forming attachments and parents' child rearing difficulties. Chapter…

  13. CERTS customer adoption model

    SciTech Connect

    Rubio, F. Javier; Siddiqui, Afzal S.; Marnay, Chris; Hamachi,Kristina S.

    2000-03-01

    This effort represents a contribution to the wider distributed energy resources (DER) research of the Consortium for Electric Reliability Technology Solutions (CERTS, http://certs.lbl.gov) that is intended to attack and, hopefully, resolve the technical barriers to DER adoption, particularly those that are unlikely to be of high priority to individual equipment vendors. The longer term goal of the Berkeley Lab effort is to guide the wider technical research towards the key technical problems by forecasting some likely patterns of DER adoption. In sharp contrast to traditional electricity utility planning, this work takes a customer-centric approach and focuses on DER adoption decision making at, what we currently think of as, the customer level. This study reports on Berkeley Lab's second year effort (completed in Federal fiscal year 2000, FY00) of a project aimed to anticipate patterns of customer adoption of distributed energy resources (DER). Marnay, et al., 2000 describes the earlier FY99 Berkeley Lab work. The results presented herein are not intended to represent definitive economic analyses of possible DER projects by any means. The paucity of data available and the importance of excluded factors, such as environmental implications, are simply too important to make such an analysis possible at this time. Rather, the work presented represents a demonstration of the current model and an indicator of the potential to conduct more relevant studies in the future.

  14. Obstacles to Interstate Adoption.

    ERIC Educational Resources Information Center

    Hunt, Roberta

    A documentation of the obstacles in law, policy and administrative procedure that interfere with effecting adoptions across State lines is presented. Major problems include: (1) Nonjudicial termination or relinquishment proceedings, although legal in many States, do not satisfy the courts in other states on the issue of the child's freedom for…

  15. A conformational model of per-O-acetyl-cyclomaltoheptaose (-beta-cyclodextrin) in solution: detection of partial inversion of glucopyranose units by NMR spectroscopy.

    PubMed

    Uccello-Barretta, Gloria; Sicoli, Giuseppe; Balzano, Federica; Salvadori, Piero

    2003-05-01

    The stereochemical features of per-O-acetyl-cyclomaltoheptaose (-beta-cyclodextrin) have been investigated in solution by NMR spectroscopy, and the deviation of functionalised glucopyranose rings from 4C(1) chairs to skew-type conformations has been detected. PMID:12706976

  16. The biological bases of conformity.

    PubMed

    Morgan, T J H; Laland, K N

    2012-01-01

    Humans are characterized by an extreme dependence on culturally transmitted information and recent formal theory predicts that natural selection should favor adaptive learning strategies that facilitate effective copying and decision making. One strategy that has attracted particular attention is conformist transmission, defined as the disproportionately likely adoption of the most common variant. Conformity has historically been emphasized as significant in the social psychology literature, and recently there have also been reports of conformist behavior in non-human animals. However, mathematical analyses differ in how important and widespread they expect conformity to be, and relevant experimental work is scarce, and generates findings that are both mutually contradictory and inconsistent with the predictions of the models. We review the relevant literature considering the causation, function, history, and ontogeny of conformity, and describe a computer-based experiment on human subjects that we carried out in order to resolve ambiguities. We found that only when many demonstrators were available and subjects were uncertain was subject behavior conformist. A further analysis found that the underlying response to social information alone was generally conformist. Thus, our data are consistent with a conformist use of social information, but as subjects' behavior is the result of both social and asocial influences, the resultant behavior may not be conformist. We end by relating these findings to an embryonic cognitive neuroscience literature that has recently begun to explore the neural bases of social learning. Here conformist transmission may be a particularly useful case study, not only because there are well-defined and tractable opportunities to characterize the biological underpinnings of this form of social learning, but also because early findings imply that humans may possess specific cognitive adaptations for effective social learning. PMID:22712006

  17. The Biological Bases of Conformity

    PubMed Central

    Morgan, T. J. H.; Laland, K. N.

    2012-01-01

    Humans are characterized by an extreme dependence on culturally transmitted information and recent formal theory predicts that natural selection should favor adaptive learning strategies that facilitate effective copying and decision making. One strategy that has attracted particular attention is conformist transmission, defined as the disproportionately likely adoption of the most common variant. Conformity has historically been emphasized as significant in the social psychology literature, and recently there have also been reports of conformist behavior in non-human animals. However, mathematical analyses differ in how important and widespread they expect conformity to be, and relevant experimental work is scarce, and generates findings that are both mutually contradictory and inconsistent with the predictions of the models. We review the relevant literature considering the causation, function, history, and ontogeny of conformity, and describe a computer-based experiment on human subjects that we carried out in order to resolve ambiguities. We found that only when many demonstrators were available and subjects were uncertain was subject behavior conformist. A further analysis found that the underlying response to social information alone was generally conformist. Thus, our data are consistent with a conformist use of social information, but as subjects’ behavior is the result of both social and asocial influences, the resultant behavior may not be conformist. We end by relating these findings to an embryonic cognitive neuroscience literature that has recently begun to explore the neural bases of social learning. Here conformist transmission may be a particularly useful case study, not only because there are well-defined and tractable opportunities to characterize the biological underpinnings of this form of social learning, but also because early findings imply that humans may possess specific cognitive adaptations for effective social learning. PMID:22712006

  18. The precaution adoption process.

    PubMed

    Weinstein, N D

    1988-01-01

    This article presents a critique of current models of preventive behavior. It discusses a variety of factors that are usually overlooked-including the appearance of costs and benefits over time, the role of cues to action, the problem of competing life demands, and the ways that actual decision behavior differs from the rational ideal implicit in expectancy-value and utility theories. Such considerations suggest that the adoption of new precautions should be viewed as a dynamic process with many determinants. The framework of a model that is able to accommodate these additional factors is described. This alternative model portrays the precaution adoption process as an orderly sequence of qualitatively different cognitive stages. Data illustrating a few of the suggestions made in the article are presented, and implications for prevention programs are discussed. PMID:3049068

  19. Open Adoption: Adoptive Parents' Reactions Two Decades Later

    ERIC Educational Resources Information Center

    Siegel, Deborah H.

    2013-01-01

    Unlike in the past, most adoption agencies today offer birth parents and adoptive parents the opportunity to share identifying information and have contact with each other. To understand the impacts of different open adoption arrangements, a qualitative descriptive study using a snowball sample of 44 adoptive parents throughout New England began…

  20. Hospitious Adoption: How Hospitality Empowers Children and Transforms Adoption

    ERIC Educational Resources Information Center

    Gritter, James L.

    2009-01-01

    Building on previous books by the author, "Hospitious Adoption: How Hospitality Empowers Children and Transforms Adoption" examines the next step after open adoption. Gritter takes the approach that practicing goodwill, respect, and courage within the realm of adoption makes the process move smoother and enriches children's lives. Following a…

  1. Analysis of plethysmographic waveform changes induced by beach chair positioning under general anesthesia.

    PubMed

    Zhu, Richard; Atteya, Gourg; Shelley, Kirk H; Silverman, David G; Alian, Aymen A

    2014-12-01

    During shoulder surgery, patients typically are placed in the beach chair position. In rare cases, this positioning has resulted in devastating outcomes of postoperative cerebral ischemia (Cullen and Kirby in APSF Newsl 22(2):25-27, 2007; Munis in APSF Newsl 22(4):82-83, 2008). This study presents a method to noninvasively and continuously hemodynamically monitor patients during beach chair positioning by using the photoplethysmograph signal recorded from a commercial pulse oximeter. Twenty-nine adults undergoing shoulder surgery were monitored before and after beach chair positioning with electrocardiogram, intermittent blood pressure, end tidal carbon dioxide, and photoplethysmograph via Nellcor finger pulse oximeter. Fast Fourier transform (FFT) was used to perform frequency-domain analysis on the photoplethysmograph (PPG) signal for data segments taken 80-120 s before and after beach chair positioning. The amplitude density of respiration-associated PPG oscillations was quantified measuring the height of the FFT peak at respiratory frequency. Results were reported as (median, interquartile range) and statistical analysis was performed using Wilcoxon sign rank test. Data were also collected when vasoactive drugs phenylephrine and ephedrine were used to maintain acceptable mean arterial pressure during a case. With beach chair positioning, all subjects who did not receive vasoactive drugs showed an increase in the FFT amplitude density of respiration-associated PPG oscillations (p < 0.0001) without change in pulse-associated PPG oscillations. The PPG was more accurate at monitoring the change to beach chair position than blood pressure or heart rate. With vasoactive drugs, pulse-associated PPG oscillations decreased only with phenylephrine while respiration-associated oscillations did not change. Frequency domain analysis of the PPG signal may be a better tool than traditional noninvasive hemodynamic parameters at monitoring patients during beach chair

  2. [Conformers of carnosine].

    PubMed

    Kliuev, S A

    2006-01-01

    The geometric and energetic parameters of most stable conformations of carnosine were calculated by the semiempirical guantum-chemical method PM3. The carnosine-water-zinc (II) clusters were simulated. PMID:16909845

  3. Assemblies of Conformal Tanks

    NASA Technical Reports Server (NTRS)

    DeLay, Tom

    2009-01-01

    Assemblies of tanks having shapes that conform to each other and/or conform to other proximate objects have been investigated for use in storing fuels and oxidizers in small available spaces in upper stages of spacecraft. Such assemblies might also prove useful in aircraft, automobiles, boats, and other terrestrial vehicles in which space available for tanks is limited. The basic concept of using conformal tanks to maximize the utilization of limited space is not new in itself: for example, conformal tanks are used in some automobiles to store windshield -washer liquid and coolant that overflows from radiators. The novelty of the present development lies in the concept of an assembly of smaller conformal tanks, as distinguished from a single larger conformal tank. In an assembly of smaller tanks, it would be possible to store different liquids in different tanks. Even if the same liquid were stored in all the tanks, the assembly would offer an advantage by reducing the mechanical disturbance caused by sloshing of fuel in a single larger tank: indeed, the requirement to reduce sloshing is critical in some applications. The figure shows a prototype assembly of conformal tanks. Each tank was fabricated by (1) copper plating a wax tank mandrel to form a liner and (2) wrapping and curing layers of graphite/epoxy composite to form a shell supporting the liner. In this case, the conformal tank surfaces are flat ones where they come in contact with the adjacent tanks. A band of fibers around the outside binds the tanks together tightly in the assembly, which has a quasi-toroidal shape. For proper functioning, it would be necessary to maintain equal pressure in all the tanks.

  4. Quantum massive conformal gravity

    NASA Astrophysics Data System (ADS)

    Faria, F. F.

    2016-04-01

    We first find the linear approximation of the second plus fourth order derivative massive conformal gravity action. Then we reduce the linearized action to separated second order derivative terms, which allows us to quantize the theory by using the standard first order canonical quantization method. It is shown that quantum massive conformal gravity is renormalizable but has ghost states. A possible decoupling of these ghost states at high energies is discussed.

  5. ESA chairs the International Living With a Star programme

    NASA Astrophysics Data System (ADS)

    2003-02-01

    chairing the ILWS steering committee for the first two years. “There is a clear need to study the Sun and its interaction with the Earth” he says, “ and it is too big a job for a single space agency to cope with.” Notes to editors The new International Living With a Star (ILWS) programme builds upon a previous international framework between Europe, Japan, Russia (formerly the Soviet Union), and the United States to study the Sun and its effects on Earth. That framework was the International Solar Terrestrial Physics (ISTP) programme. The SOHO and Cluster missions were part of ESA’s contribution. For ILWS, the Canadian Space Agency has joined the collaboration. A ‘kick-off’ meeting between the space agencies involved in ILWS was held on 4-6 September 2002 in Washington DC, United States. An international steering committee of representatives from those agencies will now supervise the programme. The committee comprises five space agencies: the National Aeronautics and Space Administration (NASA), the European Space Agency (ESA), Japan's Institute for Space and Astronautical Science (ISAS), the Russian Aviation and Space Agency (Rosaviacosmos), and the Canadian Space Agency (CSA). There will be an ILWS Working Group to coordinate special projects. More than 20 space agencies have announced their participation in the first Working Group meeting, scheduled to take place in Nice, France, on 14 -15 April 2003. Contributions from the various space agencies include missions, payloads, subsystems, launch or tracking services, rockets, balloons, and open access to data sources.

  6. Conformational sampling techniques.

    PubMed

    Hatfield, Marcus P D; Lovas, Sándor

    2014-01-01

    The potential energy hyper-surface of a protein relates the potential energy of the protein to its conformational space. This surface is useful in determining the native conformation of a protein or in examining a statistical-mechanical ensemble of structures (canonical ensemble). In determining the potential energy hyper-surface of a protein three aspects must be considered; reducing the degrees of freedom, a method to determine the energy of each conformation and a method to sample the conformational space. For reducing the degrees of freedom the choice of solvent, coarse graining, constraining degrees of freedom and periodic boundary conditions are discussed. The use of quantum mechanics versus molecular mechanics and the choice of force fields are also discussed, as well as the sampling of the conformational space through deterministic and heuristic approaches. Deterministic methods include knowledge-based statistical methods, rotamer libraries, homology modeling, the build-up method, self-consistent electrostatic field, deformation methods, tree-based elimination and eigenvector following routines. The heuristic methods include Monte Carlo chain growing, energy minimizations, metropolis monte carlo and molecular dynamics. In addition, various methods to enhance the conformational search including the deformation or smoothing of the surface, scaling of system parameters, and multi copy searching are also discussed. PMID:23947647

  7. Two-dimensionally stacked heterometallic layers hosting a discrete chair dodecameric ring of water clusters: synthesis and structural study.

    PubMed

    Kenfack Tsobnang, Patrice; Wenger, Emmanuel; Biache, Coralie; Lambi Ngolui, John; Ponou, Siméon; Dahaoui, Slimane; Lecomte, Claude

    2014-10-01

    The stacked two-dimensional supramolecular compound catena-{Co(amp)3Cr(ox)3·6H2O} (amp = 2-picolylamine, ox = oxalate) has been synthesized from the bimolecular approach using hydrogen bonds. It is built from layers in which both Co(amp)(3+) (D) and Cr(ox)(3-) (A) ions are bonded in a repeating DADADA… pattern along the a and c axes by multiple hydrogen bonds. These layers host a well resolved R12 dodecameric discrete ring of water clusters built by six independent molecules located around the 2c centrosymmetric Wyckoff positions of the P21/n space group in which the compound crystallizes. These clusters are ranged along the [001] direction, occupy 733.5 Å(3) (22.0%) of the unit cell and have a chair conformation via 12 hydrogen bonds. The water molecules of the cluster are linked with stronger hydrogen bonds than those between the cluster and its host, which explains the single continuous step of the dehydration process of the compound. PMID:25274525

  8. Adoption Research: Trends, Topics, Outcomes

    ERIC Educational Resources Information Center

    Palacios, Jesus; Brodzinsky, David

    2010-01-01

    The current article provides a review of adoption research since its inception as a field of study. Three historical trends in adoption research are identified: the first focusing on risk in adoption and identifying adoptee-nonadoptee differences in adjustment; the second examining the capacity of adopted children to recover from early adversity;…

  9. The Development of Adoption Law.

    ERIC Educational Resources Information Center

    Bussiere, Alice

    1998-01-01

    Reviews the evolution of U.S. adoption law since 1851. Recounts changes in the perceived "best interests" of all members of the adoption triad over time, and growing recognition of links between adoption and child welfare policy. Discusses current controversies including open adoption, birth parents' rights, unmarried fathers, and the role of…

  10. Becoming Lesbian Adoptive Parents: An Exploratory Study of Lesbian Adoptive, Lesbian Birth, and Heterosexual Adoptive Parents.

    ERIC Educational Resources Information Center

    Shelley-Sireci, Lynn M.; Ciano-Boyce, Claudia

    2002-01-01

    Surveyed lesbian adoptive parents, heterosexual adoptive parents, and lesbian parents who had used assisted fertilization, regarding the adoption process. Found that the process was similar for both heterosexual and lesbian parents, but lesbian adoptive parents perceived more discrimination and were more inclined to omit information during the…

  11. EHR adopters vs. non-adopters: Impacts of, barriers to, and federal initiatives for EHR adoption

    PubMed Central

    Jamoom, Eric W.; Patel, Vaishali; Furukawa, Michael F.; King, Jennifer

    2016-01-01

    While adoption of electronic health record (EHR) systems has grown rapidly, little is known about physicians’ perspectives on its adoption and use. Nationally representative survey data from 2011 are used to compare the perspectives of physicians who have adopted EHRs with those that have yet to do so across three key areas: the impact of EHRs on clinical care, practice efficiency and operations; barriers to EHR adoption; and factors that influence physicians to adopt EHRs. Despite significant differences in perspectives between adopters and non-adopters, the majority of physicians perceive that EHR use yields overall clinical benefits, more efficient practices and financial benefits. Purchase cost and productivity loss are the greatest barriers to EHR adoption among both adopters and non-adopters; although non-adopters have significantly higher rates of reporting these as barriers. Financial incentives and penalties, technical assistance, and the capability for electronic health information exchange are factors with the greatest influence on EHR adoption among all physicians. However, a substantially higher proportion of non-adopters regard various national health IT policies, and in particular, financial incentives or penalties as a major influence in their decision to adopt an EHR system. Contrasting these perspectives provides a window into how national policies have shaped adoption thus far; and how these policies may shape adoption in the near future. PMID:26250087

  12. [Self-made "electric chair" for sexually motivated child abuse of children].

    PubMed

    Rothschild, Markus A; Vendura, Klaus; Kell, Gerald

    2007-01-01

    A 52-year-old man had altered a wooden folding chair by placing two electrodes and a circuit underneath the seat. Using a remote control, he was able to give electric shocks to a person sitting on the chair. He used this device on more than 50 children, video-taping their reactions for his own pleasure. There are no reports that any of the children suffered a lasting damage to their health. The construction as well as the function and the electrical parameters of the chair were examined by forensic specialists. According to their expertise, the construction was not able to cause a potentially life-threatening condition when used with healthy children. The perpetrator was convicted for bodily harm etc. PMID:18020140

  13. Effects of differences in office chair controls, seat and backrest angle design in relation to tasks.

    PubMed

    Groenesteijn, Liesbeth; Vink, Peter; de Looze, Michiel; Krause, Frank

    2009-05-01

    In this study the influence of chair characteristics on comfort, discomfort, adjustment time and seat interface pressure is investigated during VDU and non-VDU tasks: The two investigated office chairs, both designed according to European and Dutch standards are different regarding: 1) seat cushioning and shape, 2) backrest angle and 3) controls. Thirty subjects in total, both male and female, participated in two experiments: twenty in the first and ten in the second. Significant differences are found for ease of adjustment and adjustment time of controls, independent of the tasks. Related to tasks, a significant difference was found for the backrest range of motion. For non-VDU tasks a larger range of backrest motion was preferred by 70% of the subjects. The chair design differences were most clear for comfort and adjustment time of controls, followed by comfort of backrest angle. No differences are found between seat pan comfort and discomfort, first impressions and peak interface pressure. PMID:19135185

  14. The "Chair Campaign" in Korea: an alternative approach in occupational health and safety for service workers.

    PubMed

    Lee, Yun-Keun; Kim, Shin-Bum; Chung, Jinjoo; Jung, Min-Jung; Kim, Myoung-Hee

    2011-01-01

    In spite of the increasing number of service workers in Korea, their occupational health and safety concerns have largely been neglected. It is in this context that the Chair Campaign, which lasted four months, was launched as an alternative occupational health approach for service workers. The campaign succeeded in getting wide public support, bringing about a special inspection by the Ministry of Labor. Finally, chairs were provided for workers at checkout counters in 71 department stores and 449 large discount stores. However, there are still many workplaces where workers cannot sit, whether chairs are provided or not. Although there is still much to be done, this campaign raised social awareness that service workers, mainly women, have the right to work in healthy and safe conditions. This paper will review the campaign and evaluate its achievements and limitations. PMID:21733805

  15. The founder and head of the Chair of Theoretical Physics of the Yerevan State University

    NASA Astrophysics Data System (ADS)

    Grigoryan, L. Sh

    2014-03-01

    The paper is dedicated to the Centenary of an Academician of NAS RA, Professor G S Sahakyan's birth, the Man that founded and headed the Chair of Theoretical Physics (CTP) of the Yerevan State University for almost half a century. The reference to school days of G S Sahakyan is made, information about his 7 years long service in the forces in the fields, about the establishment and administration by him of the Chair of Theoretical Physics in the Yerevan State University, about his collaboration with academician V A Ambartsumian, about the research associates of the G S Sahakyan's Chair, the students of CTP and the advancement of theoretical physics in Armenia is given. The personality characteristics of G S Sahakyan as a principal investigator and leader of CTP are analyzed.

  16. Conformal Collineations in String Cosmology

    NASA Astrophysics Data System (ADS)

    Baysal, Hüsnü; Camci, U.ğur; Tarhan, İsmail; Yilmaz, İhsan; Yavuz, İlhami; Dolgov, A.

    In this paper, we study the consequences of the existence of conformal collineations (CC) for string cloud in the context of general relativity. Especially, we interest in special conformal collineation (SCC), generated by a special affine conformal collineation (SACC) in the string cloud. Some results on the restrictions imposed by a conformal collineation symmetry in the string cloud are obtained.

  17. Conformational kinetics reveals affinities of protein conformational states

    PubMed Central

    Daniels, Kyle G.; Suo, Yang; Oas, Terrence G.

    2015-01-01

    Most biological reactions rely on interplay between binding and changes in both macromolecular structure and dynamics. Practical understanding of this interplay requires detection of critical intermediates and determination of their binding and conformational characteristics. However, many of these species are only transiently present and they have often been overlooked in mechanistic studies of reactions that couple binding to conformational change. We monitored the kinetics of ligand-induced conformational changes in a small protein using six different ligands. We analyzed the kinetic data to simultaneously determine both binding affinities for the conformational states and the rate constants of conformational change. The approach we used is sufficiently robust to determine the affinities of three conformational states and detect even modest differences in the protein’s affinities for relatively similar ligands. Ligand binding favors higher-affinity conformational states by increasing forward conformational rate constants and/or decreasing reverse conformational rate constants. The amounts by which forward rate constants increase and reverse rate constants decrease are proportional to the ratio of affinities of the conformational states. We also show that both the affinity ratio and another parameter, which quantifies the changes in conformational rate constants upon ligand binding, are strong determinants of the mechanism (conformational selection and/or induced fit) of molecular recognition. Our results highlight the utility of analyzing the kinetics of conformational changes to determine affinities that cannot be determined from equilibrium experiments. Most importantly, they demonstrate an inextricable link between conformational dynamics and the binding affinities of conformational states. PMID:26162682

  18. Sedative music reduces anxiety and pain during chair rest after open-heart surgery.

    PubMed

    Voss, Jo A; Good, Marion; Yates, Bernice; Baun, Mara M; Thompson, Austin; Hertzog, Melody

    2004-11-01

    Open-heart surgery patients report anxiety and pain with chair rest despite opioid analgesic use. The effectiveness of non-pharmacological complementary methods (sedative music and scheduled rest) in reducing anxiety and pain during chair rest was tested using a three-group pretest-posttest experimental design with 61 adult postoperative open-heart surgery patients. Patients were randomly assigned to receive 30 min of sedative music (N=19), scheduled rest (N=21), or treatment as usual (N=21) during chair rest. Anxiety, pain sensation, and pain distress were measured with visual analogue scales at chair rest initiation and 30 min later. Repeated measures MANOVA indicated significant group differences in anxiety, pain sensation, and pain distress from pretest to posttest, P<0.001. Univariate repeated measures ANOVA (P< or =0.001) and post hoc dependent t-tests indicated that in the sedative music and scheduled rest groups, anxiety, pain sensation, and pain distress all decreased significantly, P<0.001-0.015; while in the treatment as usual group, no significant differences occurred. Further, independent t-tests indicated significantly less posttest anxiety, pain sensation, and pain distress in the sedative music group than in the scheduled rest or treatment as usual groups (P<0.001-0.006). Thus, in this randomized control trial, sedative music was more effective than scheduled rest and treatment as usual in decreasing anxiety and pain in open-heart surgery patients during first time chair rest. Patients should be encouraged to use sedative music as an adjuvant to medication during chair rest. PMID:15494201

  19. Special topics in international adoption.

    PubMed

    Jenista, Jerri Ann

    2005-10-01

    As international adoption has become more "mainstream," the issues recently addressed in domestic adoption have become more important in adoptions involving children originating in other countries. Certain groups of prospective adoptive parents, such as gay or lesbian couples, single parents, and parents with disabilities, have begun to apply to adopt in ever increasing numbers. Children who may have been considered unadoptable in the past are now routinely being offered to prospective adoptive parents. The numbers and ages of the children placed and the spacing between adoptions have come under scrutiny. The rates of adoption dissolutions and disruptions are being examined carefully by the receiving and sending countries. There is a pressing need for research into numerous social aspects of adoption. PMID:16154473

  20. Conformational flexibility of mephenesin.

    PubMed

    Écija, Patricia; Evangelisti, Luca; Vallejo, Montserrat; Basterretxea, Francisco J; Lesarri, Alberto; Castaño, Fernando; Caminati, Walther; Cocinero, Emilio J

    2014-05-22

    The mephenesin molecule (3-(2-methylphenoxy)propane-1,2-diol) serves as a test bank to explore several structural and dynamical issues, such as conformational flexibility, the orientation of the carbon linear chain relative to the benzene plane, or the effect of substituent position on the rotational barrier of a methyl group. The molecule has been studied by rotational spectroscopy in the 4-18 GHz frequency range by Fourier-transform methods in a supersonic expansion. The experiment has been backed by a previous conformational search plus optimization of the lowest energy structures by ab initio and density functional quantum calculations. The three lowest-lying conformers that can interconvert to each other by simple bond rotations have been detected in the jet. Rotational parameters for all structures have been obtained, and methyl torsional barriers have been determined for the two lowest-lying rotamers. The lowest-lying structure of mephenesin is highly planar, with all carbon atoms lying nearly in the benzene ring plane, and is stabilized by the formation of cooperative intramolecular hydrogen bonding. An estimation of the relative abundance of the detected conformers indicates that the energetically most stable conformer will have an abundance near 80% at temperatures relevant for biological activity. PMID:24754523

  1. Conformers of Gaseous Serine.

    PubMed

    He, Kedan; Allen, Wesley D

    2016-08-01

    The myriad conformers of the neutral form of natural amino acid serine (Ser) have been investigated by systematic computations with reliable electronic wave function methods. A total of 85 unique conformers were located using the MP2/cc-pVTZ level of theory. The 12 lowest-energy conformers of serine fall within a 8 kJ mol(-1) window, and for these species, geometric structures, precise relative energies, equilibrium and vibrationally averaged rotational constants, anharmonic vibrational frequencies, infrared intensities, quartic and sextic centrifugal distortion constants, dipole moments, and (14)N nuclear quadrupole coupling constants were computed. The relative energies were refined through composite focal-point analyses employing basis sets as large as aug-cc-pV5Z and correlation treatments through CCSD(T). The rotational constants for seven conformers measured by Fourier-transform microwave spectroscopy are in good agreement with the vibrationally averaged rotational constants computed in this study. Our anharmonic vibrational frequencies are compared to the large number of experimental vibrational absorptions attributable to at least six conformers. PMID:27294314

  2. A Profile of Academic Training Program Directors and Chairs in Radiation Oncology

    SciTech Connect

    Wilson, Lynn D.; Haffty, Bruce G.; Smith, Benjamin D.

    2013-04-01

    Purpose: To identify objective characteristics and benchmarks for program leadership in academic radiation oncology. Methods and Materials: A study of the 87 Accreditation Council for Graduate Medical Education radiation oncology training program directors (PD) and their chairs was performed. Variables included age, gender, original training department, highest degree, rank, endowed chair assignment, National Institutes of Health (NIH) funding, and Hirsch index (H-index). Data were gathered from online sources such as departmental websites, NIH RePORTER, and Scopus. Results: There were a total of 87 PD. The median age was 48, and 14 (16%) were MD/PhD. A total of 21 (24%) were female, and rank was relatively equally distributed above instructor. Of the 26 professors, at least 7 (27%) were female. At least 24 (28%) were working at the institution from which they had received their training. A total of 6 individuals held endowed chairs. Only 2 PD had active NIH funding in 2012. The median H-index was 12 (range, 0-51) but the index dropped to 9 (range, 0-38) when those who served as both PD and chair were removed from the group. A total of 76 chairs were identified at the time of the study. The median age was 55, and 9 (12%) were MD/PhD. A total of 7 (9%) of the chairs were female, and rank was professor for all with the exception of 1 who was listed as “Head” and was an associate professor. Of the 76 chairs, at least 10 (13%) were working at the institution from which they received their training. There were a total of 21 individuals with endowed chairs. A total of 13 (17%) had NIH funding in 2012. The median H-index was 29 (range, 3-60). Conclusions: These data provide benchmarks for individuals and departments evaluating leadership positions in the field of academic radiation oncology. Such data are useful for evaluating leadership trends over time and comparing academic radiation oncology with other specialties.

  3. Reflections from a chair: Leadership of a clinical department at an academic medical center.

    PubMed

    Willett, Christopher G

    2015-11-01

    The leadership position of an academic departmental chair can be a positive and rewarding opportunity. These rewards principally stem from the success of the faculty, residents, other trainees, nurses, and everyone supporting the department. With health care reform and the constraints of the federal budget, increasing attention and time has become directed toward administrative management. There are multiple and often competing constituencies and agendas requiring thoughtful strategies to achieve departmental goals. The objectives of a chair are advancing patient care, education, and research. True excellence of a department is achieved by the innovation of its faculty. PMID:26218104

  4. Abnormal sitting pressures of hemiplegic cerebral palsy children on a school chair

    PubMed Central

    Lee, In-Hee; Park, Sang-young

    2015-01-01

    [Purpose] The purpose of this study was to investigate the differences in symmetry of sitting posture between typical developmental (TD) children and hemi-cerebral palsy (CP) children. [Subjects and Methods] A school chair mounted on a force platform was used to assess the quiet-sitting pressure distribution of 10 TD and 10 CP children. [Results] The symmetry index of the TD children was significantly closer to zero than that of the CP children irrespective of the latter group’s hemiparetic side. [Conclusions] Sitting posture on school chairs of CP children was more asymmetrical than that of TD children. PMID:25729201

  5. The emotional aftermath of adoption.

    PubMed

    Nadelson, C C

    1976-09-01

    Adopted children are emotionally vulnerable. Adoptive parents must cope with more complex problems than biologic parents. The family physician can provide valuable counseling. Preadoption counseling focuses on motivation and ambivalence. After adoption, however, serious, sometimes predictable, issues arise, such as: how and when to tell the child he is adopted; the child's search for knowledge; the problem of subsequent divorce; the birth of a natural sibling, and the involvement of other family members. New concepts include "open adoption" and "single parent adoption." PMID:961560

  6. Synthesis, structural, conformational and pharmacological study of some carbamates derived from 3-methyl-2,4-diphenyl-3- azabicyclo[3.3.1]nonan-9α-ol

    NASA Astrophysics Data System (ADS)

    Iriepa, I.; Gil-Alberdi, B.; Gálvez, E.; Bellanato, J.; Carmona, P.

    1997-04-01

    A series of benzimidazole and benzothiazole carbamates derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9α-ol has been synthesized and studied by IR, Raman, 1H and 13C NMR spectroscopy. The compounds studied display in CDCl 3 a preferred flattened chair-chair conformation. IR (at room and variable temperature) and 1H and 13C NMR data show the presence of an intramolecular NH…OC hydrogen bond in the benzimidazole carbamates. Pharmacological assays on mice were performed to evaluate analgesic activity as well as drug-induced behavioral alterations.

  7. Synthesis, structural, conformational and pharmacological study of some carbamates derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9 β-ol

    NASA Astrophysics Data System (ADS)

    Iriepa, I.; Gil-Alberdi, B.; Gálvez, E.; Villasante, F. J.; Bellanato, J.; Carmona, P.

    1999-05-01

    A series of benzimidazole and benzothiazole carbamates derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9 β-ol were synthesized and studied by IR, Raman, 1H and 13C NMR spectroscopy. The compounds studied displayed in CDCl 3 solution a preferred flattened chair-chair conformation. IR and 1H and 13C NMR data showed the presence of an intramolecular hydrogen bond in the benzimidazole carbamates. Pharmacological assays on mice were drawn to evaluate analgesic activity as well as drug-induced behavioral alterations.

  8. Raman spectra and conformations of dibenzo- and dicyclohexano-18-crown-6

    NASA Astrophysics Data System (ADS)

    Takeuchi, Hideo; Arai, Takaki; Harada, Issei

    1990-06-01

    Conformations of dibenzo-18-crown-6 (DBC), dicyclohexano-18-crown-6 (DCC) and their alkali cation complexes in the solid state and in solution have been investigated by Raman spectroscopy. The Raman spectra were analysed by using the relationships between Raman frequencies and conformations previously found for unsubstituted crown ethers. DBC takes a conformation, ( tCttGttG't) 2, with gauche ( G) or gauche' ( G') 2CH 2 bonds, trans ( t) CO bonds and cis ( C) OCCO linkages at the benzene rings, when it complexes with a cation in the solid state and in solution. Uncomplexed DBC adopts another conformation in the solid state, which contains both the trans and gauche conformations about the CH 2CH 2 and CO bonds. In solution, uncomplexed DBC exists as a mixture of conformers including the two conformers described above. Vibrational couplings between the oxyethylene and cyclohexane rings are strong in DCC and its strength depends on the crown conformation. The cation-bound crown rings of DCC isomers A and B in solution predominantly take the same conformation, ( tG'ttGt) 3, found for the crystalline isomer B-NaBr complex. A metastable conformer containing trans CH 2CH 2 bonding is found for the Na + complexes of both isomers in solution. Uncomplexed DCC adopts different crown ring conformations in isomers A and B in the solid state and diverse conformational states in solution.

  9. Adoptions Without Agencies: A Study of Independent Adoptions.

    ERIC Educational Resources Information Center

    Meezan, William; And Others

    The purposes of this national study of independent, nonagency adoptions were: (1) to determine the experience of the parties involved (biological parents, adoptive parents, agencies, intermediaries, and law enforcement agents); (2) to identify agency policies, procedures and resources that deter agency adoptions and thus encourage independent…

  10. Parents' Feelings towards Their Adoptive and Non-Adoptive Children

    ERIC Educational Resources Information Center

    Glover, Marshaun B.; Mullineaux, Paula Y.; Deater-Deckard, Kirby; Petrill, Stephen A.

    2010-01-01

    In the current study, we examined parent gender differences in feelings (negativity and positivity) and perceptions of child behavioural and emotional problems in adoptive and biological parent-child dyads. In a sample of 85 families, we used a novel within-family adoption design in which one child was adopted and one child was a biological child…

  11. Extended conformal algebras

    NASA Astrophysics Data System (ADS)

    Bouwknegt, Peter

    1988-06-01

    We investigate extensions of the Virasoro algebra by a single primary field of integer or halfinteger conformal dimension Δ. We argue that for vanishing structure constant CΔΔΔ, the extended conformal algebra can only be associative for a generic c-value if Δ=1/2, 1, 3/2, 2 or 3. For the other Δ<=5 we compute the finite set of allowed c-values and identify the rational solutions. The case CΔΔΔ≠0 is also briefly discussed. I would like to thank Kareljan Schoutens for discussions and Sander Bais for a careful reading of the manuscript.

  12. Charged conformal Killing spinors

    SciTech Connect

    Lischewski, Andree

    2015-01-15

    We study the twistor equation on pseudo-Riemannian Spin{sup c}-manifolds whose solutions we call charged conformal Killing spinors (CCKSs). We derive several integrability conditions for the existence of CCKS and study their relations to spinor bilinears. A construction principle for Lorentzian manifolds admitting CCKS with nontrivial charge starting from CR-geometry is presented. We obtain a partial classification result in the Lorentzian case under the additional assumption that the associated Dirac current is normal conformal and complete the classification of manifolds admitting CCKS in all dimensions and signatures ≤5 which has recently been initiated in the study of supersymmetric field theories on curved space.

  13. A Phenomenological Exploration of Adoption

    ERIC Educational Resources Information Center

    Baltimore, Diana L.; Crase, Sedahlia Jasper

    2009-01-01

    This qualitative analysis explored children's and adults' experiences with adoption. We used phenomenological methodology and individually interviewed 25 participants and included adoptive mothers and fathers, and their children, each adopted before 18 months of age. Two research questions guided the data analysis: (a) What are children's and…

  14. Dogmatism and Attitudes Toward Adoption

    ERIC Educational Resources Information Center

    Dembroski, Betty G.; Johnson Dale L.

    1969-01-01

    Using Rokeach's Dogmatism Scale and an Adoption Attitude Scale administered to 113 college students study supports hypothesis that among males dogmatism and intolerance toward areas relating to adoption would be positively correlated. Negative correlation for females suggests that emphasis on maternal role makes adoption attitudes exception to…

  15. Adoption Resources for Black Children

    ERIC Educational Resources Information Center

    Gallagher, Ursula M.

    1971-01-01

    The growing number of adoptions in this country, including racially mixed adoptions, attest to the general acceptance of adoption as a way of bringing love to children in need of families of their own and the satisfactions of parenthood to childless couples, single men and women, and families who have room for one more. (Author/AJ)

  16. A double diastereoselective Michael-type addition as an entry to conformationally restricted tn antigen mimics.

    PubMed

    Aydillo, Carlos; Navo, Claudio D; Busto, Jesús H; Corzana, Francisco; Zurbano, María M; Avenoza, Alberto; Peregrina, Jesús M

    2013-11-01

    A totally stereocontrolled C-Michael addition of serine-equivalent C-nucleophiles to tri-O-benzyl-2-nitro-d-galactal was used as the key step to synthesize several pyrano[3,2-b]pyrrole structures. These scaffolds could be regarded as conformationally restricted Tn antigen mimics, as we have demonstrated by biological assays. The pyranose rings retain their (4)C1 chair conformation, as shown by molecular modeling and NMR spectroscopy. The expected bioactivity was established by a competition-tailored enzyme-linked lectin assay using both soybean and Vicia villosa agglutinins as model lectins. The facile described synthetic route and the strategic combination of computational and experimental techniques to reveal conformational features and bioactivity demonstrate the prepared glycomimics to be promising candidates for further exploitation of this scaffold to give glycans for lectin blocking and vaccination. PMID:24083620

  17. Conformational changes of 1-4-glucopyranosyl residues of a sulfated C-C linked hexasaccharide.

    PubMed

    Coletti, Alessia; Elli, Stefano; Macchi, Eleonora; Galzerano, Patrizia; Zamani, Leila; Guerrini, Marco; Torri, Giangiacomo; Vismara, Elena

    2014-05-01

    This work describes the structure of a fully sulfated maltotriose alpha-beta C-C linked dimer, where a central glycosidic bond was substituted by a non natural, hydrolase-resistant C-C bond. Such compound shows anti-metastatic properties being an inhibitor of the heparanase enzymatic activity and of P-selectin-mediated cell-cell interactions. NMR spectroscopy was applied to investigate the structure and conformational properties of this C-C linked hexasaccharide. The presence of sulfate substituents and the internal C-C bond drives the two internal rings in an unusual (1)C(4) chair conformation, while the external rings linked by glycosidic bonds retain the typical (4)C(1) conformation. The NMR results were confirmed by molecular mechanics calculations using structure corresponding di- and tetrasaccharides as models. PMID:24680506

  18. Conformational changes of 1-4-glucopyranosyl residues of a sulfated C—C linked hexasaccharide

    PubMed Central

    Coletti, Alessia; Elli, Stefano; Macchi, Eleonora; Galzerano, Patrizia; Zamani, Leila; Guerrini, Marco; Torri, Giangiacomo; Vismara, Elena

    2014-01-01

    This work describes the structure of a fully sulfated maltotriose alpha–beta C—C linked dimer, where a central glycosidic bond was substituted by a non natural, hydrolase-resistant C—C bond. Such compound shows anti-metastatic properties being an inhibitor of the heparanase enzymatic activity and of P-selectin-mediated cell–cell interactions. NMR spectroscopy was applied to investigate the structure and conformational properties of this C—C linked hexasaccharide. The presence of sulfate substituents and the internal C—C bond drives the two internal rings in an unusual 1C4 chair conformation, while the external rings linked by glycosidic bonds retain the typical 4C1 conformation. The NMR results were confirmed by molecular mechanics calculations using structure corresponding di- and tetrasaccharides as models. PMID:24680506

  19. Gas-Phase Infrared and NMR Investigation of the Conformers of Diacetone Diperoxide (DADP).

    PubMed

    Guo, Chunlei; Persons, John; Woodford, Jeffrey N; Harbison, Gerard S

    2015-10-01

    Gas-phase infrared measurements of diacetone diperoxide (DADP) indicate a chair conformation with less than 5% of the predicted twist conformer. Vibrational frequencies are very similar to those previously measured in the solid state. Solution NMR measurements using 2D exchange spectroscopy (EXSY) also set a very low maximum limit on the equilibrium population of the twist conformer, with a room-temperature free-energy difference in excess of 14.5 kJ/mol. These experimental results are in accord with high-level quantum calculations incorporating full thermochemistry and solvation effects, which indicate a free-energy difference in the range of 14.7-17.5 kJ/mol in polar solvents. PMID:26387762

  20. Conformation Dependence of Backbone Geometry in Proteins

    PubMed Central

    Berkholz, Donald S.; Shapovalov, Maxim V.; Dunbrack, Roland L.; Karplus, P. Andrew

    2009-01-01

    Summary Protein structure determination and predictive modeling have long been guided by the paradigm that the peptide backbone has a single, context-independent ideal geometry. Both quantum-mechanics calculations and empirical analyses have shown this is an incorrect simplification in that backbone covalent geometry actually varies systematically as a function of the Φ and Ψ backbone dihedral angles. Here, we use a nonredundant set of ultrahigh-resolution protein structures to define these conformation-dependent variations. The trends have a rational, structural basis that can be explained by avoidance of atomic clashes or optimization of favorable electrostatic interactions. To facilitate adoption of this new paradigm, we have created a conformation-dependent library of covalent bond lengths and bond angles and shown that it has improved accuracy over existing methods without any additional variables to optimize. Protein structures derived both from crystallographic refinement and predictive modeling both stand to benefit from incorporation of the new paradigm. PMID:19836332

  1. Conformal cloak for waves

    SciTech Connect

    Chen Huanyang; Leonhardt, Ulf; Tyc, Tomas

    2011-05-15

    Conformal invisibility devices are only supposed to work within the valid range of geometrical optics. Here, we show by numerical simulations and analytical arguments that for certain quantized frequencies, they are nearly perfect even in a regime that clearly violates geometrical optics. The quantization condition follows from the analogy between the Helmholtz equation and the stationary Schroedinger equation.

  2. Extended conformal field theories

    NASA Astrophysics Data System (ADS)

    Taormina, Anne

    1990-08-01

    Some extended conformal field theories are briefly reviewed. They illustrate how non minimal models of the Virasoro algebra (c≥1) can become minimal with respect to a larger algebra. The accent is put on N-extended superconformal algebras, which are relevant in superstring compactification.

  3. PERSONALITY AND CONFORMITY.

    ERIC Educational Resources Information Center

    BAROCAS, RALPH; GORLOW, LEON

    AN INVESTIGATION WAS MADE OF THE RELATIONSHIP BETWEEN PERSONALITY FACTORS AND CONFORMITY. THE SUBJECTS WERE 243 RANDOMLY SELECTED STUDENTS ENROLLED IN COLLEGE PSYCHOLOGY COURSES WHO WERE DIVIDED INTO GROUPS OF 97, 96, AND 50 SUBJECTS. A PERSONALITY FACTOR INVENTORY WAS OBTAINED FROM RESPONSES TO A LARGE LIST OF TRUE-FALSE PERSONALITY ITEM…

  4. Animal culture: chimpanzee conformity?

    PubMed

    van Schaik, Carel P

    2012-05-22

    Culture-like phenomena in wild animals have received much attention, but how good is the evidence and how similar are they to human culture? New data on chimpanzees suggest their culture may even have an element of conformity. PMID:22625856

  5. 75 FR 11120 - Folding Metal Tables and Chairs from the People's Republic of China: Notice of Extension of Time...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... metal tables and chairs from the People's Republic of China (``PRC''). See Initiation of Antidumping and Countervailing Duty Administrative Reviews and Deferral of Administrative Review, 74 FR 37690 (July 29, 2009... International Trade Administration Folding Metal Tables and Chairs from the People's Republic of China:...

  6. 77 FR 59975 - Certain Folding Metal Tables and Chairs From China; Institution of a Five-Year Review Concerning...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... an antidumping duty order on imports of certain folding metal tables and chairs from China (67 FR... part 201), and part 207, subparts A, D, E, and F (19 CFR part 207), as most recently amended at 74 FR... chairs from China (72 FR 62626). The Commission is now conducting a second review to determine...

  7. An Investigation of the National School Board Association Key Work Standards for Public Policy Leadership and School Board Chair Performance

    ERIC Educational Resources Information Center

    Quarles, Roger C.

    2011-01-01

    This multiple case qualitative study addressed the National School Board Association's (NSBA) Key Work standards for public policy leadership by local school boards, and how three elite school board chairs understood and implemented those standards. Elite board chair status was defined by experience, training, and peer recognition. The study…

  8. Conformational changes in biopolymers

    NASA Astrophysics Data System (ADS)

    Ivanov, Vassili

    2005-12-01

    Biopolymer conformational changes are involved in many biological processes. This thesis summarizes some theoretical and experimental approaches which I have taken at UCLA to explore conformational changes in biopolymers. The reversible thermal denaturation of the DNA double helix is, perhaps, the simplest example of biopolymer conformational change. I have developed a statistical mechanics model of DNA melting with reduced degrees of freedom, which allows base stacking interaction to be taken into account and treat base pairing and stacking separately. Unlike previous models, this model describes both the unpairing and unstacking parts of the experimental melting curves and explains the observed temperature dependence of the effective thermodynamic parameters used in models of the nearest neighbor type. I developed a basic kinetic model for irreversible thermal denaturation of F-actin, which incorporates depolymerization of F-actin from the ends and breaking of F-actin fiber in the middle. The model explains the cooperativity of F-actin thermal denaturation observed by D. Pavlov et al. in differential calorimetry measurements. CG-rich DNA sequences form left-handed Z-DNA at high ionic strength or upon binding of polyvalent ions and some proteins. I studied experimentally the B-to-Z transition of the (CG)6 dodecamer. Improvement of the locally linearized model used to interpret the data gives evidence for an intermediate state in the B-to-Z transition of DNA, contrary to previous research on this subject. In the past 15 years it has become possible to study the conformational changes of biomolecules using single-molecule techniques. In collaboration with other lab members I performed a single-molecule experiment, where we monitored the displacement of a micrometer-size bead tethered to a surface by a DNA probe undergoing the conformational change. This technique allows probing of conformational changes with subnanometer accuracy. We applied the method to detect

  9. The effect of Sit 'n' Fit Chair Yoga among community-dwelling older adults with osteoarthritis.

    PubMed

    Park, Juyoung; McCaffrey, Ruth; Newman, David; Cheung, Corjena; Hagen, Dyana

    2014-01-01

    The study measured effects of Sit 'N' Fit Chair Yoga on pain and physical and psychological functioning. A quasi-experimental research design included a yoga intervention group and an attention control group. There was greater improvement in depression and life satisfaction in the yoga group than in the control group. PMID:24919095

  10. Principals Fostering the Instructional Leadership Capacities of Department Chairs: A Strategy for Urban High School Reform

    ERIC Educational Resources Information Center

    Klar, Hans W.

    2013-01-01

    A growing body of literature has highlighted the affordances of distributive forms of instructional leadership as a means to broaden and deepen instructional leadership capacity within schools. Yet, specifically how the capabilities of such key leaders as high school department chairs can be fostered to realize enhanced instructional capacity…

  11. Defining and Activating the Role of Department Chair as Instructional Leader

    ERIC Educational Resources Information Center

    Kelley, Carolyn; Salisbury, Jason

    2013-01-01

    With strong connection to schoolwide policy and vision and to the realities of the daily life of teachers and students, the department chair is uniquely positioned to play an important role in advancing instructional effectiveness (Printy, 2008; Weller, 2001). This article provides an in-depth look at the efforts of three urban comprehensive high…

  12. Cultivating Sacramentality through Administrative Work: Guidance from St. Benedict on Being a Catholic Department Chair

    ERIC Educational Resources Information Center

    Narloch, Rodger

    2014-01-01

    One dilemma encountered by department chairs and administrators at Catholic colleges and universities is how to respect the pluralistic religious views of the faculty while being faithful to one's own and the institution's Catholic tradition. The Rule of St. Benedict offers guidance that can result in deepening the respect for all…

  13. The Department Chair's Role in Developing New Faculty into Teachers and Scholars.

    ERIC Educational Resources Information Center

    Bensimon, Estela Mara; Ward, Kelly; Sanders, Karla

    This book is designed to help department chairs with three stages of junior faculty socialization: recruitment and hiring; the critical first year; and evaluating the performance of new faculty. The book is organized in three parts with 15 chapters. Chapters in Part 1, "Managing the Recruitment and Selection of New Faculty," include: (1)…

  14. Resolving Decisional Conflict by Gestalt Two-Chair Dialogue: Relating Process to Outcome.

    ERIC Educational Resources Information Center

    Greenberg, Leslie S.; Webster, Michael C.

    1982-01-01

    Clients (N=31) completed a six-week program using Gestalt two-chair dialog to work on intrapsychic conflict related to the making of a decision. Clients were classified as resolvers or nonresolvers. Resolvers were found to be significantly less undecided and less anxious after treatment. (Author)

  15. Views from a Distance: A Nephological Model of the CCCC Chairs' Addresses, 1977-2011

    ERIC Educational Resources Information Center

    Mueller, Derek N.

    2012-01-01

    Views from a Distance is a series of word clouds rendered from 35 chairs' addresses delivered at CCCC conventions from 1977 to 2011. The digital installation invites explorations of word-level patterns and anomalies within this widely recognized collection of speeches. The installation itself is underpinned with the assumption that distinctive…

  16. Designing and Building a Cardboard Chair: Children's Engineering at the TECA Eastern Regional Conference

    ERIC Educational Resources Information Center

    Linnell, Charles C.

    2007-01-01

    This article describes the 2006 Technology Education Collegiate Association (TECA) Eastern Regional elementary competition, wherein teams of technology education students from nine different universities designed and built cardboard chairs. The competition required the teams (four or five to a team) from universities up and down the East Coast to…

  17. Governance under Siege: An Interview with the Chair of the Northern Illinois University Board of Trustees

    ERIC Educational Resources Information Center

    Trusteeship, 2008

    2008-01-01

    On February 14, a former graduate student at Northern Illinois University (NIU) entered a campus building and shot 21 people, wounding five fatally, before he shot and killed himself. This article presents an interview with Cherilyn G. Murer, the Chair of the Northern Illinois University Board of Trustees, on the actions taken by the board and the…

  18. Leadership Strategies of Exemplary High School Department Chairs: Four Case Studies of Successful "Middle Managers."

    ERIC Educational Resources Information Center

    Wettersten, Jill A.

    This paper presents findings of case studies that applied social exchange theory to examine the instructional leadership roles of four exemplary high school department chairs. Data were gathered at four suburban high schools in a large metropolitan area of the midwestern United States using the methods of observation and interviews with the…

  19. 20 CFR 661.320 - Who must chair a Local Board?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false Who must chair a Local Board? 661.320 Section 661.320 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) STATEWIDE AND LOCAL GOVERNANCE OF THE WORKFORCE INVESTMENT SYSTEM UNDER TITLE I OF THE WORKFORCE...

  20. The Cockpit's Empty Chair: Education through Appropriating Alienation at a Chicago Technology Museum

    ERIC Educational Resources Information Center

    Lormier, Anne

    2007-01-01

    Background/Context: In the United States, the percentage of schoolchildren planning to become high-status professionals is grossly disproportionate to the percentage of such jobs comprising our division of labor. As in a game of musical chairs, it is not structurally possible for everyone to remain a contender. Focus of Study: Various adults who…

  1. Tenure Standards in Political Science Departments: Results from a Survey of Department Chairs

    ERIC Educational Resources Information Center

    Rothgeb, John M., Jr.; Burger, Betsy

    2009-01-01

    This article presents the results from a survey of political science department chairs regarding the tenure procedures and standards at their colleges or universities. The findings reveal that only a small fraction of the colleges and universities in the United States refuse to offer tenure or are attempting to limit tenure. We also find general…

  2. 21 CFR 868.5365 - Posture chair for cardiac or pulmonary treatment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Posture chair for cardiac or pulmonary treatment. 868.5365 Section 868.5365 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5365 Posture...

  3. 21 CFR 868.5365 - Posture chair for cardiac or pulmonary treatment.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Posture chair for cardiac or pulmonary treatment. 868.5365 Section 868.5365 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5365 Posture...

  4. 21 CFR 868.5365 - Posture chair for cardiac or pulmonary treatment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Posture chair for cardiac or pulmonary treatment. 868.5365 Section 868.5365 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5365 Posture...

  5. 21 CFR 868.5365 - Posture chair for cardiac or pulmonary treatment.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Posture chair for cardiac or pulmonary treatment. 868.5365 Section 868.5365 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5365 Posture...

  6. 21 CFR 868.5365 - Posture chair for cardiac or pulmonary treatment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Posture chair for cardiac or pulmonary treatment. 868.5365 Section 868.5365 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES ANESTHESIOLOGY DEVICES Therapeutic Devices § 868.5365 Posture...

  7. Evaluation of Chair-Side Assays in High Microbiological Caries-Risk Subjects.

    PubMed

    Saravia, Marta Estela; Silva, Lea Assed Bezerra; Silva, Raquel Assed Bezerra; Lucisano, Marília Pacífico; Echevarría, Andrea Uribe; Echevarría, Jorge Uribe; Nelson-Filho, Paulo

    2015-01-01

    The aim of this study was to evaluate the commercial chair-side assays Saliva-Check Mutans and ClinproTM Cario L-PopTM in high microbiological caries-risk dental students compared with conventional semi-quantitative colony counting culture-based technique as the reference method. Saliva samples from 93 subjects of both sexes aged 18-26 years were seeded (Köhler and Bratthall method) on plates containing SB-20M culture medium method and 12 subjects with high caries risk were selected. These 12 individuals were subjected to determination of caries risk using two commercial rapid detection chair-side assays (Saliva-Check Mutans and ClinproTM Cario L-PopTM) according to the manufacturers' instructions. The results were analyzed by the Kappa correlation test using SAS statistical software. There was a perfect agreement (Kappa=1) among the three caries risk evaluation methods - chair-side assays and semi-quantitative CFU count (control) - in all subjects. The results suggest that the commercial chair-side assays evaluated in this study may be practical and useful to identify high microbiological caries-risk subjects. PMID:26963201

  8. Observation of Classroom Performance Using Therapy Balls as a Substitute for Chairs in Elementary School Children

    ERIC Educational Resources Information Center

    Burgoyne, Molly E.; Ketcham, Caroline J.

    2015-01-01

    Many classrooms are beginning to substitute standard chairs with therapy balls, which help to improve students' focus and classroom performance, according to teacher and student reports. Researchers conducted an observational study in a classroom at a local elementary school that implemented therapy balls. For each hour-long observation, three…

  9. What Every Department Chair Should Know about the Dean: Findings from Four National Surveys.

    ERIC Educational Resources Information Center

    Bowker, Lee H.; Lynch, David M.

    Information about deans that may be helpful to department chairs is presented, based on the findings of four national surveys of deans. The surveys of social science, graduate, continuing education, and arts and sciences deans covered the deans' role in resource allocation to departments, teaching and research support for faculty, tenure and…

  10. Design of Lesehan Chair by Using Kansei Engineering Method And Anthropometry Approach

    NASA Astrophysics Data System (ADS)

    Pambudi, A. T.; Suryoputro, M. R.; Sari, A. D.; Kurnia, R. D.

    2016-01-01

    Special Region of Yogyakarta (DIY) is known as city for academic. Many people come to get some education in college. They live in boarding house with some supporting facilities. The most common facilities is low table which lead students have to sit on the floor while studying on table which could cause higher risk of back pain and musculoskeletal disorder. To identify the solution to reduce back pain and musculoskeletal risk, it is needed to design a lesehan chair which also appropriate to customer needs. Kansei engineering method was used with a total of 30 respondents participated, 15 kansei words collected, and 12 kansei words selected by doing validation and reliability test. The result of this study showed that quality, aesthetics, and comfort level influence the design of lesehan chair. A design of lesehan chair was created by considering the suitable concept and merging it with the physical design and its anthropometry measurement. In this case, marginal homogeneity test is needed to identify the differences between each kansei words attribute and the design or product recommendation. The marginal homogeneity test results show that the design and product recommendation has fulfilled customer's desires and needs. For further research, it is needed to analyse and evaluate the posture of lesehan chair users in order to develop and improve its performance.

  11. CCSF Survey on Using Technology: Administrators, Department Chairs, Classified Staff, and Student Services.

    ERIC Educational Resources Information Center

    City Coll. of San Francisco, CA. Office of Institutional Research, Planning and Grants.

    This document discusses the findings of a survey completed by all employees of City College of San Francisco in 2003. The employees surveyed include administrators, department chairs, classified staff, and student service faculty. The survey discovered that these employees differ from instructional faculty in the following ways: (1) they do their…

  12. 21 CFR 878.4950 - Manual operating table and accessories and manual operating chair and accessories.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Manual operating table and accessories and manual operating chair and accessories. 878.4950 Section 878.4950 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY...

  13. 21 CFR 878.4950 - Manual operating table and accessories and manual operating chair and accessories.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Manual operating table and accessories and manual operating chair and accessories. 878.4950 Section 878.4950 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY...

  14. 21 CFR 878.4960 - Operating tables and accessories and operating chairs and accessories.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Operating tables and accessories and operating chairs and accessories. 878.4960 Section 878.4960 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES...

  15. 21 CFR 878.4960 - Operating tables and accessories and operating chairs and accessories.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Operating tables and accessories and operating chairs and accessories. 878.4960 Section 878.4960 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES...

  16. 21 CFR 878.4960 - Operating tables and accessories and operating chairs and accessories.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Operating tables and accessories and operating chairs and accessories. 878.4960 Section 878.4960 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES...

  17. 21 CFR 878.4960 - Operating tables and accessories and operating chairs and accessories.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Operating tables and accessories and operating chairs and accessories. 878.4960 Section 878.4960 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES...

  18. 21 CFR 878.4950 - Manual operating table and accessories and manual operating chair and accessories.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Manual operating table and accessories and manual operating chair and accessories. 878.4950 Section 878.4950 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY...

  19. 21 CFR 878.4960 - Operating tables and accessories and operating chairs and accessories.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Operating tables and accessories and operating chairs and accessories. 878.4960 Section 878.4960 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY DEVICES...

  20. 21 CFR 878.4950 - Manual operating table and accessories and manual operating chair and accessories.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Manual operating table and accessories and manual operating chair and accessories. 878.4950 Section 878.4950 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GENERAL AND PLASTIC SURGERY...

  1. K-theory of the chair tiling via AF-algebras

    NASA Astrophysics Data System (ADS)

    Julien, Antoine; Savinien, Jean

    2016-08-01

    We compute the K-theory groups of the groupoid C∗-algebra of the chair tiling, using a new method. We use exact sequences of Putnam to compute these groups from the K-theory groups of the AF-algebras of the substitution and the induced lower dimensional substitutions on edges and vertices.

  2. Differential Effects of the Gestalt Two-Chair Intervention and Problem Solving in Resolving Decisional Conflict.

    ERIC Educational Resources Information Center

    Clarke, Katherine M.; Greenberg, Leslie S.

    1986-01-01

    Compared an affective (Gestalt two-chair intervention) and a cognitive-behavioral (problem-solving) counseling intervention used to help clients resolve intrapersonal conflicts related to a decision. A one-way analysis of variance revealed that affective intervention was more effective than cognitive behavioral intervention or no treatment for…

  3. Pity the Program Chair: A Brief Guide to Preparing Academic Proposals.

    ERIC Educational Resources Information Center

    Bowman, Joel P.

    1994-01-01

    Discusses conference program proposals from the perspective of a former cochair of several international and regional scholarly conference committees. Describes the duties of program chairs. Outlines the way conference program decisions are meted out. Provides suggestions for perfect conference proposals. (HB)

  4. 76 FR 17118 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site-Specific... Board is to make recommendations to DOE-EM and site management in the areas of environmental...

  5. 75 FR 17701 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-07

    ... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site-Specific... environmental restoration, waste management, and related activities. Tentative Agenda Topics: Wednesday,...

  6. 78 FR 20311 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of Open Webinar. SUMMARY: This notice announces a webinar of the Environmental Management Site-Specific... recommendations to DOE-EM and site management in the areas of environmental restoration, waste management,...

  7. 76 FR 62054 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-06

    ... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of open teleconference. SUMMARY: This notice announces a teleconference of the Environmental Management... make recommendations to DOE-EM and site management in the areas of environmental restoration,...

  8. 77 FR 55813 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site-Specific... Board is to make recommendations to DOE-EM and site management in the areas of environmental...

  9. 78 FR 59012 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site-Specific... environmental restoration, waste management, and related activities. Tentative Agenda Topics: Wednesday,...

  10. 75 FR 51450 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site-Specific... the Board is to make recommendations ] to DOE-EM and site management in the areas of...

  11. 78 FR 64208 - Environmental Management Site-Specific Advisory Board Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-28

    ... Environmental Management Site-Specific Advisory Board Chairs AGENCY: Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Environmental Management Site-Specific... environmental restoration, waste management, and related activities. Tentative Agenda Topics: Tuesday,...

  12. The Role of the Chair of the School Governing Body in England

    ERIC Educational Resources Information Center

    James, Chris; Jones, Jeff; Connolly, Michael; Brammer, Steve; Fertig, Mike; James, Jane

    2012-01-01

    The research reported here analysed the role of the chair of the school governing body in England, drawing on a national survey of governors and the study of governing in 30 schools. The role encompassed: being a governor; appointing and working with the head teacher; acting as a change agent; active participation in the school; organising the…

  13. 76 FR 45845 - Notice of Issuance of Final Determination Concerning a Certain Patient Transport Chair

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... Border Protection (``CBP'') has issued a final determination concerning the country of origin of a... determination that the U.S. is the country of origin of the patient transport chair for purposes of U.S... B), CBP issued a final determination concerning the country of origin of the BREEZ patient...

  14. Galilean conformal and superconformal symmetries

    SciTech Connect

    Lukierski, J.

    2012-10-15

    Firstly we discuss briefly three different algebras named as nonrelativistic (NR) conformal: Schroedinger, Galilean conformal, and infinite algebra of local NR conformal isometries. Further we shall consider in some detail Galilean conformal algebra (GCA) obtained in the limit c{yields}{infinity} from relativistic conformal algebraO(d+1, 2) (d-number of space dimensions). Two different contraction limits providing GCA and some recently considered realizations will be briefly discussed. Finally by considering NR contraction of D = 4 superconformal algebra the Galilei conformal superalgebra (GCSA) is obtained, in the formulation using complexWeyl supercharges.

  15. Effect of a suspension seat support chair on the trunk flexion angle and gluteal pressure during computer work

    PubMed Central

    Yoo, Won-gyu

    2015-01-01

    [Purpose] We assessed the effects of a suspension seat support chair on the trunk flexion angle and gluteal pressure during computer work. [Subjects] Ten males were recruited. [Methods] The suspension seat support was developed to prevent abnormal gluteal pressure and a slumped sitting posture during computer work. The gluteal pressure was measured with a TekScan system and the trunk flexion angle was measured with a video camera, to compare the differences between a general chair and the suspension seat support. [Results] The gluteal peak pressures were decreased significantly in the suspension seat support versus the general chair. The trunk flexion angle was also decreased significantly in the suspension seat support compared with the general chair. [Conclusions] This study suggests that the suspension seat support chair contributes to preventing abnormal gluteal pressure and a slumped sitting posture. PMID:26504341

  16. 18 CFR 415.51 - Prior non-conforming structures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... structures. 415.51 Section 415.51 Conservation of Power and Water Resources DELAWARE RIVER BASIN COMMISSION... structures. A structure which was lawful before the adoption of this regulation but which is not in... this part): (a) A non-conforming structure in the floodway may not be expanded, except that it may...

  17. Technology Adoption: an Interaction Perspective

    NASA Astrophysics Data System (ADS)

    Sitorus, Hotna M.; Govindaraju, Rajesri; Wiratmadja, I. I.; Sudirman, Iman

    2016-02-01

    The success of a new technology depends on how well it is accepted by its intended users. Many technologies face the problem of low adoption rate, despite the benefits. An understanding of what makes people accept or reject a new technology can help speed up the adoption rate. This paper presents a framework for technology adoption based on an interactive perspective, resulting from a literature study on technology adoption. In studying technology adoption, it is necessary to consider the interactions among elements involved in the system, for these interactions may generate new characteristics or new relationships. The interactions among elements in a system adoption have not received sufficient consideration in previous studies of technology adoption. Based on the proposed interaction perspective, technology adoption is elaborated by examining interactions among the individual (i.e. the user or prospective user), the technology, the task and the environment. The framework is formulated by adopting several theories, including Perceived Characteristics of Innovating, Diffusion of Innovation Theory, Technology Acceptance Model, Task-Technology Fit and usability theory. The proposed framework is illustrated in the context of mobile banking adoption. It is aimed to offer a better understanding of determinants of technology adoption in various contexts, including technology in manufacturing systems.

  18. Movement of Elongation Factor G between Compact and Extended Conformations

    PubMed Central

    Salsi, Enea; Farah, Elie; Netter, Zoe; Dann, Jillian; Ermolenko, Dmitri N.

    2014-01-01

    Previous structural studies suggested that ribosomal translocation is accompanied by large interdomain rearrangements of elongation factor G (EF-G). Here, we follow the movement of domain IV of EF-G relative to domain II of EF-G using ensemble and single-molecule Förster resonance energy transfer (smFRET). Our results indicate that ribosome-free EF-G predominantly adopts a compact conformation that can also, albeit infrequently, transition into a more extended conformation in which domain IV moves away from domain II. By contrast, ribosome-bound EF-G predominantly adopts an extended conformation regardless of whether it is interacting with pre- or posttranslocation ribosomes. Our data suggest that ribosome-bound EF-G may also occasionally sample at least one more compact conformation. GTP hydrolysis catalyzed by EF-G does not affect the relative stability of the observed conformations in ribosome-free and ribosome-bound EF-G. Our data support a model suggesting that, upon binding to a pretranslocation ribosome, EF-G moves from a compact to a more extended conformation. This transition is not coupled to, but likely precedes both GTP hydrolysis and mRNA/tRNA translocation. PMID:25463439

  19. Intercountry versus Transracial Adoption: Analysis of Adoptive Parents' Motivations and Preferences in Adoption

    ERIC Educational Resources Information Center

    Zhang, Yuanting; Lee, Gary R.

    2011-01-01

    The United States is one of the major baby-receiving countries in the world. Relatively little research has focused on why there is such a high demand for intercountry adoption. Using in-depth qualitative interviews with adoptive parents, the authors explored the reasons why Americans prefer to adopt foreign-born children instead of adopting…

  20. Computational mutagenesis reveals the role of active-site tyrosine in stabilising a boat conformation for the substrate: QM/MM molecular dynamics studies of wild-type and mutant xylanases.

    PubMed

    Soliman, Mahmoud E S; Ruggiero, Giuseppe D; Pernía, J Javier Ruiz; Greig, Ian R; Williams, Ian H

    2009-02-01

    Molecular dynamics simulations have been performed for non-covalent complexes of phenyl beta-xylobioside with the retaining endo-beta-1,4-xylanase from B. circulans (BCX) and its Tyr69Phe mutant using a hybrid QM/MM methodology. A trajectory initiated for the wild-type enzyme-substrate complex with the proximal xylose ring bound at the -1 subsite (adjacent to the scissile glycosidic bond) in the (4)C(1) chair conformation shows spontaneous transformation to the (2,5)B boat conformation, and potential of mean force calculations indicate that the boat is approximately 30 kJ mol(-1) lower in free energy than the chair. Analogous simulations for the mutant lacking one oxygen atom confirm the key role of Tyr69 in stabilizing the boat in preference to the (4)C(1) chair conformation, with a relative free energy difference of about 20 kJ mol(-1), by donating a hydrogen bond to the endocyclic oxygen of the proximal xylose ring. QM/MM MD simulations for phenyl beta-xyloside in water, with and without a propionate/propionic acid pair to mimic the catalytic glutamate/glutamic acid pair of the enzyme, show the (4)C(1) chair to be stable, although a hydrogen bond between the OH group at C2 of xylose and the propionate moiety seems to provide some stabilization for the (2,5)B conformation. PMID:19156310

  1. Multiscale conformal pattern transfer

    PubMed Central

    Lodewijks, Kristof; Miljkovic, Vladimir; Massiot, Inès; Mekonnen, Addis; Verre, Ruggero; Olsson, Eva; Dmitriev, Alexandre

    2016-01-01

    We demonstrate a method for seamless transfer from a parent flat substrate of basically any lithographic top-down or bottom-up pattern onto essentially any kind of surface. The nano- or microscale patterns, spanning macroscopic surface areas, can be transferred with high conformity onto a large variety of surfaces when such patterns are produced on a thin carbon film, grown on top of a sacrificial layer. The latter allows lifting the patterns from the flat parent substrate onto a water-air interface to be picked up by the host surface of choice. We illustrate the power of this technique by functionalizing broad range of materials including glass, plastics, metals, rough semiconductors and polymers, highlighting the potential applications in in situ colorimetry of the chemistry of materials, anti-counterfeit technologies, biomolecular and biomedical studies, light-matter interactions at the nanoscale, conformal photovoltaics and flexible electronics. PMID:27329824

  2. Multiscale conformal pattern transfer

    NASA Astrophysics Data System (ADS)

    Lodewijks, Kristof; Miljkovic, Vladimir; Massiot, Inès; Mekonnen, Addis; Verre, Ruggero; Olsson, Eva; Dmitriev, Alexandre

    2016-06-01

    We demonstrate a method for seamless transfer from a parent flat substrate of basically any lithographic top-down or bottom-up pattern onto essentially any kind of surface. The nano- or microscale patterns, spanning macroscopic surface areas, can be transferred with high conformity onto a large variety of surfaces when such patterns are produced on a thin carbon film, grown on top of a sacrificial layer. The latter allows lifting the patterns from the flat parent substrate onto a water-air interface to be picked up by the host surface of choice. We illustrate the power of this technique by functionalizing broad range of materials including glass, plastics, metals, rough semiconductors and polymers, highlighting the potential applications in in situ colorimetry of the chemistry of materials, anti-counterfeit technologies, biomolecular and biomedical studies, light-matter interactions at the nanoscale, conformal photovoltaics and flexible electronics.

  3. Multiscale conformal pattern transfer.

    PubMed

    Lodewijks, Kristof; Miljkovic, Vladimir; Massiot, Inès; Mekonnen, Addis; Verre, Ruggero; Olsson, Eva; Dmitriev, Alexandre

    2016-01-01

    We demonstrate a method for seamless transfer from a parent flat substrate of basically any lithographic top-down or bottom-up pattern onto essentially any kind of surface. The nano- or microscale patterns, spanning macroscopic surface areas, can be transferred with high conformity onto a large variety of surfaces when such patterns are produced on a thin carbon film, grown on top of a sacrificial layer. The latter allows lifting the patterns from the flat parent substrate onto a water-air interface to be picked up by the host surface of choice. We illustrate the power of this technique by functionalizing broad range of materials including glass, plastics, metals, rough semiconductors and polymers, highlighting the potential applications in in situ colorimetry of the chemistry of materials, anti-counterfeit technologies, biomolecular and biomedical studies, light-matter interactions at the nanoscale, conformal photovoltaics and flexible electronics. PMID:27329824

  4. Conformal gripping device

    NASA Technical Reports Server (NTRS)

    Vranish, John M. (Inventor)

    2009-01-01

    The present invention relates to a conformal gripping device. In an embodiment of the present invention a conformal gripper device may be disclosed comprising a frame that includes an array of movable pins. The device may also include a roller locking and unlocking system within the frame. The system may comprise a pair of locking rollers for each row of gripper pins to facilitate locking and unlocking the array of gripper pins on a column-by-column basis. The system may also include a striker element that may force the locking rollers to roll along an angled roll surface to facilitate unlocking of the array of pins on a column-by-column basis. The system may further include an electromagnetic actuator or solenoid and permanent magnets to facilitate movement of the striker element and the locking rollers.

  5. Conformational flexibility of aspartame.

    PubMed

    Toniolo, Claudio; Temussi, Pierandrea

    2016-05-01

    L-Aspartyl-L-phenylalanine methyl ester, better known as aspartame, is not only one of the most used artificial sweeteners, but also a very interesting molecule with respect to the correlation between molecular structure and taste. The extreme conformational flexibility of this dipeptide posed a huge difficulty when researchers tried to use it as a lead compound to design new sweeteners. In particular, it was difficult to take advantage of its molecular model as a mold to infer the shape of the, then unknown, active site of the sweet taste receptor. Here, we follow the story of the 3D structural aspects of aspartame from early conformational studies to recent docking into homology models of the receptor. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 376-384, 2016. PMID:27038223

  6. The conformal bootstrap

    NASA Astrophysics Data System (ADS)

    Poland, David; Simmons-Duffin, David

    2016-06-01

    The conformal bootstrap was proposed in the 1970s as a strategy for calculating the properties of second-order phase transitions. After spectacular success elucidating two-dimensional systems, little progress was made on systems in higher dimensions until a recent renaissance beginning in 2008. We report on some of the main results and ideas from this renaissance, focusing on new determinations of critical exponents and correlation functions in the three-dimensional Ising and O(N) models.

  7. Conformal scalar field wormholes

    NASA Technical Reports Server (NTRS)

    Halliwell, Jonathan J.; Laflamme, Raymond

    1989-01-01

    The Euclidian Einstein equations with a cosmological constant and a conformally coupled scalar field are solved, taking the metric to be of the Robertson-Walker type. In the case Lambda = 0, solutions are found which represent a wormhole connecting two asymptotically flat Euclidian regions. In the case Lambda greater than 0, the solutions represent tunneling from a small Tolman-like universe to a large Robertson-Walker universe.

  8. Conformations of organophosphine oxides

    DOE PAGESBeta

    De Silva, Nuwan; Zahariev, Federico; Hay, Benjamin P.; Gordon, Mark S.; Windus, Theresa L.

    2015-07-17

    The conformations of a series of organophosphine oxides, OP(CH3)2R, where R = methyl, ethyl, isopropyl, tert-butyl, vinyl, and phenyl, are predicted using the MP2/cc-pVTZ level of theory. Comparison of potential energy surfaces for rotation about P–C bonds with crystal structure data reveals a strong correlation between predicted location and energetics of minima and histograms of dihedral angle distributions observed in the solid state. In addition, the most stable conformers are those that minimize the extent of steric repulsion between adjacent rotor substituents, and the torsional barriers tend to increase with the steric bulk of the rotating alkyl group. MM3 forcemore » field parameters were adjusted to fit the MP2 results, providing a fast and accurate model for predicting organophosphine oxides shapes—an essential part of understanding the chemistry of these compounds. As a result, the predictive power of the modified MM3 model was tested against MP2/cc-pVTZ conformations for triethylphosphine oxide, OP(CH2CH3)3, and triphenylphosphine oxide, OP(Ph)3.« less

  9. Conformations of organophosphine oxides

    SciTech Connect

    De Silva, Nuwan; Zahariev, Federico; Hay, Benjamin P.; Gordon, Mark S.; Windus, Theresa L.

    2015-07-17

    The conformations of a series of organophosphine oxides, OP(CH3)2R, where R = methyl, ethyl, isopropyl, tert-butyl, vinyl, and phenyl, are predicted using the MP2/cc-pVTZ level of theory. Comparison of potential energy surfaces for rotation about P–C bonds with crystal structure data reveals a strong correlation between predicted location and energetics of minima and histograms of dihedral angle distributions observed in the solid state. In addition, the most stable conformers are those that minimize the extent of steric repulsion between adjacent rotor substituents, and the torsional barriers tend to increase with the steric bulk of the rotating alkyl group. MM3 force field parameters were adjusted to fit the MP2 results, providing a fast and accurate model for predicting organophosphine oxides shapes—an essential part of understanding the chemistry of these compounds. As a result, the predictive power of the modified MM3 model was tested against MP2/cc-pVTZ conformations for triethylphosphine oxide, OP(CH2CH3)3, and triphenylphosphine oxide, OP(Ph)3.

  10. Hot conformal gauge theories

    NASA Astrophysics Data System (ADS)

    Mojaza, Matin; Pica, Claudio; Sannino, Francesco

    2010-12-01

    We compute the nonzero temperature free energy up to the order g6ln⁡(1/g) in the coupling constant for vectorlike SU(N) gauge theories featuring matter transforming according to different representations of the underlying gauge group. The number of matter fields, i.e. flavors, is arranged in such a way that the theory develops a perturbative stable infrared fixed point at zero temperature. Because of large distance conformality we trade the coupling constant with its fixed point value and define a reduced free energy which depends only on the number of flavors, colors, and matter representation. We show that the reduced free energy changes sign, at the second, fifth, and sixth order in the coupling, when decreasing the number of flavors from the upper end of the conformal window. If the change in sign is interpreted as a signal of an instability of the system then we infer a critical number of flavors. Surprisingly this number, if computed to the order g2, agrees with previous predictions for the lower boundary of the conformal window for nonsupersymmetric gauge theories. The higher order results tend to predict a higher number of critical flavors. These are universal properties, i.e. they are independent of the specific matter representation.

  11. Dissecting conformational contributions to glycosidase catalysis and inhibition

    PubMed Central

    Speciale, Gaetano; Thompson, Andrew J; Davies, Gideon J; Williams, Spencer J

    2014-01-01

    Glycoside hydrolases (GHs) are classified into >100 sequence-based families. These enzymes process a wide variety of complex carbohydrates with varying stereochemistry at the anomeric and other ring positions. The shapes that these sugars adopt upon binding to their cognate GHs, and the conformational changes that occur along the catalysis reaction coordinate is termed the conformational itinerary. Efforts to define the conformational itineraries of GHs have focussed upon the critical points of the reaction: substrate-bound (Michaelis), transition state, intermediate (if relevant) and product-bound. Recent approaches to defining conformational itineraries that marry X-ray crystallography of enzymes bound to ligands that mimic the critical points, along with advanced computational methods and kinetic isotope effects are discussed. PMID:25016573

  12. Openness in Adoption: Research with the Adoption Kinship Network.

    ERIC Educational Resources Information Center

    Grotevant, Harold D.

    2000-01-01

    Summarizes current research on the outcomes of open adoption. Discusses issues involved in conducting research on openness and offers methodological recommendations. Provides examples from one research program with adoptive kinship networks. Concludes that psychological outcomes were less related to the level of openness than to the dynamics of…

  13. Adoption and Assisted Reproduction. Adoption and Ethics, Volume 4.

    ERIC Educational Resources Information Center

    Freundlich, Madelyn

    The controversies in adoption have extended across a spectrum of policy and practice issues, and although the issues have become clear, resolution has not been achieved nor has consensus developed regarding a framework on which to improve the quality of adoption policy and practice. This book is the fourth in a series to use an ethics-based…

  14. Homosexuality and adoption in Brazil.

    PubMed

    Uziel, A P

    2001-11-01

    Western societies are undergoing legal and policy changes in relation to laws governing the family, marital status, sexual orientation and the welfare of children, including in Brazil where, in the 1990s, the rights of homosexuals were incorporated into ongoing debates about what constitutes a family. This paper discusses the issue of adoption of children by homosexual men in Brazil, using information from court records from 1995-2000 in Rio de Janeiro, and from interviews with two judges, five psychologists and four social workers who evaluate those wishing to adopt. It uses the case records of one man's application to adopt, in which homosexuality became a central issue. Both the construction of masculinity in relation to parenting and concepts of the family were the parameters upon which the decision to allow him to adopt or not depended. Because the legislation does not specify what the sexual orientation of would-be adoptive parents should be, it is possible for single persons to adopt if they show they can be good parents. As more single people, alone or in couples, seek to adopt, it is important to clarify the criteria for judicial decisions on adoption applications. A dialogue is therefore needed on the meaning of family and whether and how it relates to sexual orientation. It is only on this basis that the courts can take a clear decision as to whether being homosexual is a relevant issue in regard to applications to adopt or not. PMID:11765396

  15. Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis.

    PubMed

    Wodtke, Robert; Ruiz-Gómez, Gloria; Kuchar, Manuela; Pisabarro, M Teresa; Novotná, Pavlina; Urbanová, Marie; Steinbach, Jörg; Pietzsch, Jens; Löser, Reik

    2015-02-14

    The collagen telopeptides play an important role for lysyl oxidase-mediated crosslinking, a process which is deregulated during tumour progression. The DEKS motif which is located within the N-terminal telopeptide of the α1 chain of type I collagen has been suggested to adopt a βI-turn conformation upon docking to its triple-helical receptor domain, which seems to be critical for lysyl oxidase-catalysed deamination and subsequent crosslinking by Schiff-base formation. Herein, the design and synthesis of cyclic peptides which constrain the DEKS sequence in a β-turn conformation will be described. Lysine-side chain attachment to 2-chlorotrityl chloride-modified polystyrene resin followed by microwave-assisted solid-phase peptide synthesis and on-resin cyclisation allowed for an efficient access to head-to-tail cyclised DEKS-derived cyclic penta- and hexapeptides. An N(ε)-(4-fluorobenzoyl)lysine residue was included in the cyclopeptides to allow their potential radiolabelling with fluorine-18 for PET imaging of lysyl oxidase. Conformational analysis by (1)H NMR and chiroptical (electronic and vibrational CD) spectroscopy together with MD simulations demonstrated that the concomitant incorporation of a D-proline and an additional lysine for potential radiolabel attachment accounts for a reliable induction of the desired βI-turn structure in the DEKS motif in both DMSO and water as solvents. The stabilised conformation of the cyclohexapeptide is further reflected by its resistance to trypsin-mediated degradation. In addition, the deaminated analogue containing allysine in place of lysine has been synthesised via the corresponding ε-hydroxynorleucine containing cyclohexapeptide. Both ε-hydroxynorleucine and allysine containing cyclic hexapeptides have been subjected to conformational analysis in the same manner as the lysine-based parent structure. Thus, both a conformationally restricted lysyl oxidase substrate and product have been synthetically accessed, which

  16. Conformal superalgebras via tractor calculus

    NASA Astrophysics Data System (ADS)

    Lischewski, Andree

    2015-01-01

    We use the manifestly conformally invariant description of a Lorentzian conformal structure in terms of a parabolic Cartan geometry in order to introduce a superalgebra structure on the space of twistor spinors and normal conformal vector fields formulated in purely algebraic terms on parallel sections in tractor bundles. Via a fixed metric in the conformal class, one reproduces a conformal superalgebra structure that has been considered in the literature before. The tractor approach, however, makes clear that the failure of this object to be a Lie superalgebra in certain cases is due to purely algebraic identities on the spinor module and to special properties of the conformal holonomy representation. Moreover, it naturally generalizes to higher signatures. This yields new formulas for constructing new twistor spinors and higher order normal conformal Killing forms out of existing ones, generalizing the well-known spinorial Lie derivative. Moreover, we derive restrictions on the possible dimension of the space of twistor spinors in any metric signature.

  17. Improvement of the Chairs in Classrooms for Better Sitting Posture of Children

    NASA Astrophysics Data System (ADS)

    Ishihara, Keiko; Dake, Kazuo; Ishihara, Shigekazu

    2010-10-01

    We sought to improve the sitting postures of children studying in the classrooms of a primary school. We made the seat of a standard chair lower and attached a cushion designed by one of the authors. The cushion is cut at a 25° downward angle toward the legs to allow the users to support their weight with their feet and alleviate pressure on the underside of the thighs. We also lowered the desktop to below the height of children's elbows. Eighty-three children were given the new chairs and desks, and they were observed over 7 months. Around 10% of them voluntarily maintained good sitting postures; others straightened their postures when the teachers reminded them to do so.

  18. Development of a Virtual Presence Sharing System Using a Telework Chair

    NASA Astrophysics Data System (ADS)

    Ishii, Yutaka; Watanabe, Tomio

    There has been much discussion on remote communication support for a telework that will enable employees to work at remote offices. We have already developed a remote communication support system via embodied avatars based on users’ behaviors. However, there are various problems associated with an avatar-mediated interaction, particularly with regard to the relation between users and their avatars. In this study, we propose the concept of a presence sharing system Ghatcha [GHost Avatar on a Telework CHAir] in which the users’ embodiment is not indicated by the avatars but by the chairs that suggest the presence of avatars. This system provides the same communication space for the users’ embodiment, thus creating a feeling of working alongside remote workers. Moreover, the effectiveness of the prototype system is confirmed in the experiment.

  19. Molecular Dynamics Studies on the Conformational Transitions of Adenylate Kinase: A Computational Evidence for the Conformational Selection Mechanism

    PubMed Central

    Ping, Jie; Hao, Pei; Li, Yi-Xue; Wang, Jing-Fang

    2013-01-01

    Escherichia coli adenylate kinase (ADK) is a monomeric phosphotransferase enzyme that catalyzes reversible transfer of phosphoryl group from ATP to AMP with a large-scale domain motion. The detailed mechanism for this conformational transition remains unknown. In the current study, we performed long time-scale molecular dynamics simulations on both open and closed states of ADK. Based on the structural analyses of the simulation trajectories, we detected over 20 times conformational transitions between the open and closed states of ADK and identified two novel conformations as intermediate states in the catalytic processes. With these findings, we proposed a possible mechanism for the large-scale domain motion of Escherichia coli ADK and its catalytic process: (1) the substrate free ADK adopted an open conformation; (2) ATP bound with LID domain closure; (3) AMP bound with NMP domain closure; (4) phosphoryl transfer occurred with ATP, and AMP converted into two ADPs, and no conformational transition was detected in the enzyme; (5) LID domain opened with one ADP released; (6) another ADP released with NMP domain open. As both open and closed states sampled a wide range of conformation transitions, our simulation strongly supported the conformational selection mechanism for Escherichia coli ADK. PMID:23936827

  20. Stories of Aboriginal Transracial Adoption

    ERIC Educational Resources Information Center

    Nuttgens, Simon

    2013-01-01

    Despite the significant number of transracial Aboriginal adoptions that have taken place in Canada, little research is available that addresses the psychological and psychosocial ramifications for the children involved. The scant literature that does exist raises concerns about the psychological impact of this type of adoption. The present…

  1. Faculty Adoption of Educational Technology

    ERIC Educational Resources Information Center

    Moser, Franziska Zellweger

    2007-01-01

    Although faculty support has been identified as a critical factor in the success of educational-technology programs, many people involved in such efforts underestimate the complexities of integrating technology into teaching. In this article, the author proposes an adoption cycle to help tackle the complex issue of technology adoption for…

  2. The Temporal Context of Adoption.

    ERIC Educational Resources Information Center

    Pontius, Steven K.

    This paper analyzes the amount of time required by farmers in four villages on the western edge of the central plain of Thailand to adopt four agricultural innovations--fertilizer, herbicide, insecticide, and fungicide. The general objective is to help researchers interested in the relationship of the adoption of new ideas to economic development…

  3. OSI Conformance Testing for Bibliographic Applications.

    ERIC Educational Resources Information Center

    Arbez, Gilbert; Swain, Leigh

    1990-01-01

    Describes the development of Open Systems Interconnection (OSI) conformance testing sites, conformance testing tools, and conformance testing services. Discusses related topics such as interoperability testing, arbitration testing, and international harmonization of conformance testing. A glossary is included. (24 references) (SD)

  4. Sinusoidal rotatory chair system by an auto-tuning fuzzy PID controller

    SciTech Connect

    Park, H.A.; Cha, I.S.; Baek, H.L.

    1995-12-31

    This paper presents DC servo motor speed control characteristics by fuzzy logic controller and considers position following control response with controller. A sinusoidal rotatory chair system using an auto tuning fuzzy PID control was designed to evaluate the vestibular function. Then the system is investigated for the effects of change by the fuzziness of fuzzy variable. If this system is supported by a channel, it is considered for application in industry of multi joint robot and precision parallel driving.

  5. Leaf growth is conformal.

    PubMed

    Alim, Karen; Armon, Shahaf; Shraiman, Boris I; Boudaoud, Arezki

    2016-01-01

    Growth pattern dynamics lie at the heart of morphogenesis. Here, we investigate the growth of plant leaves. We compute the conformal transformation that maps the contour of a leaf at a given stage onto the contour of the same leaf at a later stage. Based on the mapping we predict the local displacement field in the leaf blade and find it to agree with the experimentally measured displacement field to 92%. This approach is applicable to any two-dimensional system with locally isotropic growth, enabling the deduction of the whole growth field just from observation of the tissue contour. PMID:27597439

  6. Metamaterials with conformational nonlinearity

    NASA Astrophysics Data System (ADS)

    Lapine, Mikhail; Shadrivov, Ilya V.; Powell, David A.; Kivshar, Yuri S.

    2011-11-01

    Within a decade of fruitful development, metamaterials became a prominent area of research, bridging theoretical and applied electrodynamics, electrical engineering and material science. Being man-made structures, metamaterials offer a particularly useful playground to develop interdisciplinary concepts. Here we demonstrate a novel principle in metamaterial assembly which integrates electromagnetic, mechanical, and thermal responses within their elements. Through these mechanisms, the conformation of the meta-molecules changes, providing a dual mechanism for nonlinearity and offering nonlinear chirality. Our proposal opens a wide road towards further developments of nonlinear metamaterials and photonic structures, adding extra flexibility to their design and control.

  7. Characteristics of adopted juvenile delinquents.

    PubMed

    Kim, W J; Zrull, J P; Davenport, C W; Weaver, M

    1992-05-01

    There have been many reports describing the uniqueness of adopted children and adolescents' delinquent behaviors in terms of both their delinquent characteristics and courts' treatment of them. A total of 43 adopted juveniles, 32 extrafamilial (1.0%) and 11 intrafamilial (0.3%) adoptions were initially identified out of 3,280 juvenile delinquents. The adopted subjects were then compared with the demographically matched and offense matched nonadopted subjects. The family variables, such as marital and employment status of parents, were significantly different. However, there were only a few discernible trends, and in general there were no significant differences between the adopted and nonadopted juveniles in terms of their offense characteristics and dispositions. PMID:1592787

  8. [Creation of the first university chair in psychiatry: Johann Christian August Heinroth in Leipzig].

    PubMed

    Steinberg, H

    2004-03-01

    Much research has been done on the work of the alleged "psychicist" Johann Christian August Heinroth (1773-1843). However, his academic career has not yet been investigated in depth. For the first time, original archive material and other sources are quoted to illuminate his history and that of the first European chair of psychiatry at Leipzig University in Germany. Heinroth was first appointed associate professor (without a specific subject), and on 21 October 1811 he became the first associate professor of "psychic therapy". Despite his efforts, this chair was not transformed into a fellow professorship in 1815. In 1819, Heinroth succeeded in being appointed fellow professor, but for medicine in general and not psychiatry in particular. Thus his position was upgraded but his subject was not. After Heinroth's death in 1843, Justus Radius (1797-1884) took over psychiatry as a third, "part-time" chair. After several shifts in responsibilities, he ceased being explicitly referred to as professor of psychiatry. PMID:15021930

  9. Child and adolescent psychiatry in general children's hospitals. A survey of chairs of psychiatry.

    PubMed

    Campo, J V; Kingsley, R S; Bridge, J; Mrazek, D

    2000-01-01

    This article characterizes the academic, administrative, clinical service, and fiscal characteristics of departments of psychiatry in traditional children's hospitals to determine the characteristics of fiscally successful programs. A survey of chairs of psychiatry from short-term general children's hospitals was conducted based on 38 questions addressing the descriptive characteristics of their respective departments. The characteristics of psychiatry programs identified as fiscally successful were compared to those of programs that required subsidy. Nine of 45 eligible children's hospitals (20%) did not have a department or section of psychiatry, and surveys were returned by 35 of 36 department chairs (97% response). Considerable variation exists in the academic, administrative, clinical services, and fiscal characteristics of programs, although over half are operating at a deficit. Fiscal success was associated with availability of inpatient and intermediate levels of psychiatric care, better integration of the psychiatry program within the children's hospital, and adequate fiscal information being provided to the psychiatry chair. Additional research regarding the potential of psychiatric services to generate clinical success and cost savings is warranted. Pediatric health care professionals and third-party payers should be educated regarding the relevance of psychiatric services within children's hospitals and in physically ill children. PMID:10749950

  10. Effects of chair restraint on the strength of the tibia in rhesus monkeys

    NASA Technical Reports Server (NTRS)

    Hutchinson, T. M.; Bakulin, A. V.; Rakhmanov, A. S.; Martin, R. B.; Steele, C. R.; Arnaud, S. B.

    2001-01-01

    To determine the effects of the relative inactivity and unloading on the strength of the tibias of monkeys, Macaca mulatta, we used a non-invasive test to measure bending stiffness, or EI (Nm2), a mechanical property. The technique was validated by comparisons of in vivo measurements with standard measures of EI in the same bones post-mortem (r2 = 0.95, P < 0.0001). Inter-test precision was 4.28+/-1.4%. Normative data in 24 monkeys, 3.0+/-0.7 years and 3.6+/-0.6 kg, revealed EI to be 16% higher in the right than left tibia (4.4+/-1.6 vs. 3.7+/-1.6 Nm2, P < 0.05). Five monkeys, restrained in chairs for 14 days, showed decreases in EI. There were no changes in EI in two chaired monkeys that lost weight during a 2-week space flight. The factors that account for both the decreases in bone mechanical properties after chair restraint at 1 g and lack of change after microgravity remain to be identified. Metabolic factors associated with body weight changes are suggested by our results.

  11. Repositioning chairs in benign paroxysmal positional vertigo: implications and clinical outcome.

    PubMed

    West, Niels; Hansen, Søren; Møller, Martin Nue; Bloch, Sune Land; Klokker, Mads

    2016-03-01

    The objective was to evaluate the clinical value of repositioning chairs in management of refractory benign paroxysmal positional vertigo (BPPV) and to study how different BPPV subtypes respond to treatment. We performed a retrospective chart review of 150 consecutive cases with refractory vertigo referred to our clinic within a 10-month period. The BPPV patients were managed with classical manual manoeuvres, the Epley Omniax(®) rotator (EO) or the TRV chair (TRV). In addition, a comprehensive review of the literature was performed. BPPV was identified in 95 cases. The number of needed treatments for posterior canalolithiasis versus posterior cupulolithiasis, horizontal cupulolithiasis and multi-canal affection was significant (p < 0.01). Thirty-seven (38 %) patients required only one repositioning manoeuvre and the overall symptom relief was 91.7-100 % after 3 treatments. Eleven patients (12 %) experienced relapse within the ½-year follow-up period. Horizontal cupulolithiasis and multi-canal affection constituted the most resilient cases. The literature search identified 9 repositioning chair studies. The EO and the TRV are highly valuable assets in diagnosis and management of BPPV of particularly complex and refractory cases. However, further validation is anticipated through controlled clinical trials. PMID:25749489

  12. Fluid shifts and endocrine responses during chair rest and water immersion in man

    NASA Technical Reports Server (NTRS)

    Greenleaf, J. E.; Shvartz, E.; Kravik, S.; Keil, L. C.

    1980-01-01

    The effects of external water pressure on intercompartmental fluid volume shifts and endocrine responses in man are investigated. Extracellular fluid volumes and plasma and urine electrolyte and endocrine responses of four male subjects were measured during eight hours of head-out water immersion and 16 hours of recovery bed rest and compared to responses obtained during eight hours of chair rest and 16 hours of bed rest without external hydrostatic pressure obtained in the same subjects five months later. Immersion is found to result in a substantial diuresis with respect to chair rest, accounted for by decreases in extracellular volume. A negative water balance during immersion and a positive water balance during chair rest were observed to be accompanied by a shift of extracellular volume to the intracellular compartment, as well as the suppression of plasma arginine vasopressin and renin activities in both regimes. The vasopressin and renin activity decreases are attributed to the increased central blood volume, and half of the plasma loss in immersed subjects is attributed to the effects of external water pressure.

  13. Conformational selection or induced fit? 50 years of debate resolved

    PubMed Central

    Edelstein, Stuart

    2011-01-01

    Exactly 50 years ago, biochemists raised the question of the mechanism of the conformational change that mediates “allosteric” interactions between regulatory sites and biologically active sites in regulatory/receptor proteins. Do the different conformations involved already exist spontaneously in the absence of the regulatory ligands (Monod-Wyman-Changeux), such that the complementary protein conformation would be selected to mediate signal transduction, or do particular ligands induce the receptor to adopt the conformation best suited to them (Koshland-Nemethy-Filmer—induced fit)? This is not just a central question for biophysics, it also has enormous importance for drug design. Recent advances in techniques have allowed detailed experimental and theoretical comparisons with the formal models of both scenarios. Also, it has been shown that mutated receptors can adopt constitutively active confirmations in the absence of ligand. There have also been demonstrations that the atomic resolution structures of the same protein are essentially the same whether ligand is bound or not. These and other advances in past decades have produced a situation where the vast majority of the data using different categories of regulatory proteins (including regulatory enzymes, ligand-gated ion channels, G protein-coupled receptors, and nuclear receptors) support the conformational selection scheme of signal transduction. PMID:21941598

  14. Conformally symmetric traversable wormholes

    SciTech Connect

    Boehmer, Christian G.; Harko, Tiberiu; Lobo, Francisco S. N.

    2007-10-15

    Exact solutions of traversable wormholes are found under the assumption of spherical symmetry and the existence of a nonstatic conformal symmetry, which presents a more systematic approach in searching for exact wormhole solutions. In this work, a wide variety of solutions are deduced by considering choices for the form function, a specific linear equation of state relating the energy density and the pressure anisotropy, and various phantom wormhole geometries are explored. A large class of solutions impose that the spatial distribution of the exotic matter is restricted to the throat neighborhood, with a cutoff of the stress-energy tensor at a finite junction interface, although asymptotically flat exact solutions are also found. Using the 'volume integral quantifier', it is found that the conformally symmetric phantom wormhole geometries may, in principle, be constructed by infinitesimally small amounts of averaged null energy condition violating matter. Considering the tidal acceleration traversability conditions for the phantom wormhole geometry, specific wormhole dimensions and the traversal velocity are also deduced.

  15. Eikonalization of conformal blocks

    SciTech Connect

    Fitzpatrick, A. Liam; Kaplan, Jared; Walters, Matthew T.; Wang, Junpu

    2015-09-03

    Classical field configurations such as the Coulomb potential and Schwarzschild solution are built from the t-channel exchange of many light degrees of freedom. We study the CFT analog of this phenomenon, which we term the 'eikonalization' of conformal blocks. We show that when an operator T appears in the OPE Ο(x)Ο(0), then the large spin Fock space states [TT···T] also appear in this OPE with a computable coefficient. The sum over the exchange of these Fock space states in an correlator build the classical 'T field' in the dual AdS description. In some limits the sum of all Fock space exchanges can be represented as the exponential of a single T exchange in the 4-pt correlator of O. Our results should be useful for systematizing 1/ℓ perturbation theory in general CFTs and simplifying the computation of large spin OPE coefficients. As examples we obtain the leading log ℓ dependence of Fock space conformal block coefficients, and we directly compute the OPE coefficients of the simplest ‘triple-trace’ operators.

  16. Eikonalization of conformal blocks

    DOE PAGESBeta

    Fitzpatrick, A. Liam; Kaplan, Jared; Walters, Matthew T.; Wang, Junpu

    2015-09-03

    Classical field configurations such as the Coulomb potential and Schwarzschild solution are built from the t-channel exchange of many light degrees of freedom. We study the CFT analog of this phenomenon, which we term the 'eikonalization' of conformal blocks. We show that when an operator T appears in the OPE Ο(x)Ο(0), then the large spin Fock space states [TT···T]ℓ also appear in this OPE with a computable coefficient. The sum over the exchange of these Fock space states in an correlator build the classical 'T field' in the dual AdS description. In some limits the sum of all Fock spacemore » exchanges can be represented as the exponential of a single T exchange in the 4-pt correlator of O. Our results should be useful for systematizing 1/ℓ perturbation theory in general CFTs and simplifying the computation of large spin OPE coefficients. As examples we obtain the leading log ℓ dependence of Fock space conformal block coefficients, and we directly compute the OPE coefficients of the simplest ‘triple-trace’ operators.« less

  17. 76 FR 35007 - Notice of Issuance of Final Determination Concerning the Country of Origin of Certain Office Chairs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... components. The components from China of the SAYL chairs include: casters, tilt assembly, cylinder, arm... liner may be sewn into the back side of the cover. A button hole also is sewn into the back side of...

  18. Recent Advances in Conformal Gravity

    NASA Astrophysics Data System (ADS)

    O'Brien, James; Chaykov, Spasen

    2016-03-01

    In recent years, significant advances have been made in alternative gravitational theories. Although MOND remains the leading candidate among the alternative models, Conformal Gravity has been studied by Mannheim and O'Brien to solve the rotation curve problem without the need for dark matter. Recently, Mannheim, O'Brien and Chaykov have begun solving other gravitational questions in Conformal Gravity. In this presentation, we highlight the new work of Conformal Gravity's application to random motions of clusters (the original Zwicky problem), gravitational bending of light, gravitational lensing and a very recent survey of dwarf galaxy rotation curves. We will show in each case that Conformal Gravity can provide an accurate explanation and prediction of the data without the need for dark matter. Coupled with the fact that Conformal Gravity is a fully re-normalizable metric theory of gravity, these results help to push Conformal Gravity onto a competitive stage against other alternative models.

  19. Structural, conformational and pharmacological study of some amides derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9 β-amine as potential analgesics

    NASA Astrophysics Data System (ADS)

    Iriepa, I.; Gil-Alberdi, B.; Gálvez, E.; Herranz, M. J.; Bellanato, J.; Carmona, P.; Orjales, A.; Berisa, A.; Labeaga, L.

    1999-05-01

    A series of amides derived from 3-methyl-2,4-diphenyl-3-azabicyclo[3.3.1]nonan-9 β-amine were synthesized and studied by IR, Raman, 1H and 13C NMR spectroscopy. The compounds studied displayed in CDCl 3 a preferred flattened chair-chair conformation. IR (at room and variable temperature) and 1H and 13C NMR data showed the presence of an intramolecular NH⋯N-heterocyclic hydrogen bond in the pirazine derivative ( IV). Pharmacological assays on mice were drawn to evaluate drug-induced behavioral alteration peripheral or central acute toxicity and analgesic activity.

  20. Conformal Gravity and Gravitational Waves

    NASA Astrophysics Data System (ADS)

    Fabbri, Luca; Paranjape, M. B.

    We consider monochromatic, plane gravitational waves in a conformally invariant theory of general relativity. We show that the simple, standard ansatz for the metric, usually that which is taken for the linearized theory of these waves, is reducible to the metric of Minkowski spacetime via a sequence of conformal and coordinate transformations. This implies that we have in fact, exact plane wave solutions. However they are simply coordinate/conformal artifacts. As a consequence, they carry no energy.

  1. Killing and conformal Killing tensors

    NASA Astrophysics Data System (ADS)

    Heil, Konstantin; Moroianu, Andrei; Semmelmann, Uwe

    2016-08-01

    We introduce an appropriate formalism in order to study conformal Killing (symmetric) tensors on Riemannian manifolds. We reprove in a simple way some known results in the field and obtain several new results, like the classification of conformal Killing 2-tensors on Riemannian products of compact manifolds, Weitzenböck formulas leading to non-existence results, and construct various examples of manifolds with conformal Killing tensors.

  2. Effectiveness of a Batteryless and Wireless Wearable Sensor System for Identifying Bed and Chair Exits in Healthy Older People.

    PubMed

    Torres, Roberto Luis Shinmoto; Visvanathan, Renuka; Hoskins, Stephen; van den Hengel, Anton; Ranasinghe, Damith C

    2016-01-01

    Aging populations are increasing worldwide and strategies to minimize the impact of falls on older people need to be examined. Falls in hospitals are common and current hospital technological implementations use localized sensors on beds and chairs to alert caregivers of unsupervised patient ambulations; however, such systems have high false alarm rates. We investigate the recognition of bed and chair exits in real-time using a wireless wearable sensor worn by healthy older volunteers. Fourteen healthy older participants joined in supervised trials. They wore a batteryless, lightweight and wireless sensor over their attire and performed a set of broadly scripted activities. We developed a movement monitoring approach for the recognition of bed and chair exits based on a machine learning activity predictor. We investigated the effectiveness of our approach in generating bed and chair exit alerts in two possible clinical deployments (Room 1 and Room 2). The system obtained recall results above 93% (Room 2) and 94% (Room 1) for bed and chair exits, respectively. Precision was >78% and 67%, respectively, while F-score was >84% and 77% for bed and chair exits, respectively. This system has potential for real-time monitoring but further research in the final target population of older people is necessary. PMID:27092506

  3. Commentary: getting to the next phase in medical education--a role for the vice-chair for education.

    PubMed

    Pangaro, Louis N

    2012-08-01

    The author argues that a particular kind of departmental leadership is needed lest medical education become hostage both to distant management through regulatory metrics (which can displace local, institutional creativity) and to the financial pressures within the institution. Departmental chairs themselves have often been seen as barriers to successful integration and redesign of medical school curricula. The vice-chair for education is a critical figure in achieving this new kind of leadership.The author describes three forms of curriculum planning and management: phase 1, where the department chair makes the decisions; phase 2, dominated by regulation from above (in part a reaction to problems with the phase 1 approach); and phase 3, the author's vision of an approach in which decisions occur within departments but with an awareness of the institution as a collaborative system, and grounded in educational theory and research. The vice-chair for education would have a key role, carrying out interdepartmental planning and assessment for the chairs, who would provide them the needed time, training (in leadership and in educational theory and practice), support (from professional educators, with advanced degrees in education), and routes to academic advancement.Responding effectively to a complex and changing environment requires senior leaders at the middle-management level (such as vice-chairs for education) who are well trained in both the content of their specialties and also in interpersonal and collaborative skills, and who have the desire to reach a common future. PMID:22827983

  4. Effectiveness of a Batteryless and Wireless Wearable Sensor System for Identifying Bed and Chair Exits in Healthy Older People

    PubMed Central

    Shinmoto Torres, Roberto Luis; Visvanathan, Renuka; Hoskins, Stephen; van den Hengel, Anton; Ranasinghe, Damith C.

    2016-01-01

    Aging populations are increasing worldwide and strategies to minimize the impact of falls on older people need to be examined. Falls in hospitals are common and current hospital technological implementations use localized sensors on beds and chairs to alert caregivers of unsupervised patient ambulations; however, such systems have high false alarm rates. We investigate the recognition of bed and chair exits in real-time using a wireless wearable sensor worn by healthy older volunteers. Fourteen healthy older participants joined in supervised trials. They wore a batteryless, lightweight and wireless sensor over their attire and performed a set of broadly scripted activities. We developed a movement monitoring approach for the recognition of bed and chair exits based on a machine learning activity predictor. We investigated the effectiveness of our approach in generating bed and chair exit alerts in two possible clinical deployments (Room 1 and Room 2). The system obtained recall results above 93% (Room 2) and 94% (Room 1) for bed and chair exits, respectively. Precision was >78% and 67%, respectively, while F-score was >84% and 77% for bed and chair exits, respectively. This system has potential for real-time monitoring but further research in the final target population of older people is necessary. PMID:27092506

  5. Loop Virasoro Lie conformal algebra

    SciTech Connect

    Wu, Henan Chen, Qiufan; Yue, Xiaoqing

    2014-01-15

    The Lie conformal algebra of loop Virasoro algebra, denoted by CW, is introduced in this paper. Explicitly, CW is a Lie conformal algebra with C[∂]-basis (L{sub i} | i∈Z) and λ-brackets [L{sub i} {sub λ} L{sub j}] = (−∂−2λ)L{sub i+j}. Then conformal derivations of CW are determined. Finally, rank one conformal modules and Z-graded free intermediate series modules over CW are classified.

  6. Reflections on conformal spectra

    NASA Astrophysics Data System (ADS)

    Kim, Hyungrok; Kravchuk, Petr; Ooguri, Hirosi

    2016-04-01

    We use modular invariance and crossing symmetry of conformal field theory to reveal approximate reflection symmetries in the spectral decompositions of the partition function in two dimensions in the limit of large central charge and of the four-point function in any dimension in the limit of large scaling dimensions Δ0 of external operators. We use these symmetries to motivate universal upper bounds on the spectrum and the operator product expansion coefficients, which we then derive by independent techniques. Some of the bounds for four-point functions are valid for finite Δ0 as well as for large Δ0. We discuss a similar symmetry in a large spacetime dimension limit. Finally, we comment on the analogue of the Cardy formula and sparse light spectrum condition for the four-point function.

  7. Capturing Chromosome Conformation

    NASA Astrophysics Data System (ADS)

    Dekker, Job; Rippe, Karsten; Dekker, Martijn; Kleckner, Nancy

    2002-02-01

    We describe an approach to detect the frequency of interaction between any two genomic loci. Generation of a matrix of interaction frequencies between sites on the same or different chromosomes reveals their relative spatial disposition and provides information about the physical properties of the chromatin fiber. This methodology can be applied to the spatial organization of entire genomes in organisms from bacteria to human. Using the yeast Saccharomyces cerevisiae, we could confirm known qualitative features of chromosome organization within the nucleus and dynamic changes in that organization during meiosis. We also analyzed yeast chromosome III at the G1 stage of the cell cycle. We found that chromatin is highly flexible throughout. Furthermore, functionally distinct AT- and GC-rich domains were found to exhibit different conformations, and a population-average 3D model of chromosome III could be determined. Chromosome III emerges as a contorted ring.

  8. Influence of Crystal Packing on Global Protein Conformation

    NASA Astrophysics Data System (ADS)

    Ahlstrom, Logan; Miyashita, Osamu

    2011-10-01

    X-ray crystallography is the most robust method for solving protein structure. However, packing forces in the crystal lattice select just a snapshot of a protein's conformational ensemble, whereas proteins are flexible and can adopt different conformations. Here we compare molecular dynamics (MD) simulations in solution and the crystal lattice to add dynamical insight to the static X-ray images of proteins. As a model system, we consider the λ Cro dimer, whose solved X-ray structures range from a ``closed'' to an ``open'' global conformation. Free energy profiles depicting the conformational space sampled by the dimer in solution show some reported structures correspond to stable states. Yet other conformations, while accessible, lie higher in energy, indicating the effect of crystal packing. Subsequent crystal MD simulations estimated the strength of packing interfaces in the lattice, showing the influence of crystal form and mutation in stabilizing different dimer conformations. Our quantitative results will aid analysis of X-ray data in establishing protein structure-function relationships.

  9. Oligothiophene wires: impact of torsional conformation on the electronic structure.

    PubMed

    Kislitsyn, D A; Taber, B N; Gervasi, C F; Zhang, L; Mannsfeld, S C B; Prell, J S; Briseno, A L; Nazin, G V

    2016-02-14

    Charge transport in polymer- and oligomer-based semiconductor materials depends strongly on the structural ordering of the constituent molecules. Variations in molecular conformations influence the electronic structures of polymers and oligomers, and thus impact their charge-transport properties. In this study, we used Scanning Tunneling Microscopy and Spectroscopy (STM/STS) to investigate the electronic structures of different alkyl-substituted oligothiophenes displaying varied torsional conformations on the Au(111) surface. STM imaging showed that on Au(111), oligothiophenes self-assemble into chain-like structures, binding to each other via interdigitated alkyl ligands. The molecules adopted distinct planar conformations with alkyl ligands forming cis- or trans- mutual orientations. For each molecule, by using STS mapping, we identify a progression of particle-in-a-box-like states corresponding to the LUMO, LUMO+1 and LUMO+2 orbitals. Analysis of STS data revealed very similar unoccupied molecular orbital energies for different possible molecular conformations. By using density functional theory calculations, we show that the lack of variation in molecular orbital energies among the different oligothiophene conformers implies that the effect of the Au-oligothiophene interaction on molecular orbital energies is nearly identical for all studied torsional conformations. Our results suggest that cis-trans torsional disorder may not be a significant source of electronic disorder and charge carrier trapping in organic semiconductor devices based on oligothiophenes. PMID:26804474

  10. Conformations of 1-heptene secondary ozonide as studied by low temperature FT-IR spectroscopy

    NASA Astrophysics Data System (ADS)

    Bariseviciute, R.; Ceponkus, J.; Sablinskas, V.; Kimtys, L.

    2007-11-01

    Conformational diversity of the 1-heptene secondary ozonides (SOZ) in solid neat films as well as isolated in Ar or CO 2 matrices was studied by the means of FT-IR absorption spectroscopy. The ozonization reaction was performed at 77 K in the neat films of the reactants. The spectra of the ozonide were analyzed by combining the experimental data with the results of theoretical calculations performed at B3LYP 6-311++G (3df, 3pd) level. It was found that the samples of 1-heptene secondary ozonide exist as a mixture of three dominating conformers. The most stable conformer is the one with O-O half-chair configuration of the five membered ring, the aliphatic radical attached to the ring in equatorial position and the aliphatic chain being in gauche (∠OCCC ≈ -60°) position. The other two stable conformers are equatorial with aliphatic chain in anti (∠OCCC ≈ 180°) and gauche (∠OCCC ≈ 60°) positions. It was found from Van't Hoff plots that Δ H of the equatorial anti conformer is equal to 0.24 ± 0.03 kJ/mol. The experimental value of Δ H is in reasonable accordance to the calculated one - 0.5 kJ/mol.

  11. Molecular structure and conformational preferences of gaseous 1-iodo-1-silacyclohexane

    NASA Astrophysics Data System (ADS)

    Belyakov, A. V.; Baskakov, A. A.; Berger, R. J. F.; Mitzel, N. W.; Oberhammer, H.; Arnason, I.; Wallevik, S. Ò.

    2012-03-01

    The molecular structure of the axial and equatorial conformers of 1-iodo-1-silacyclohexane, CH2(CH2CH2)2SiH-I, as well as thermodynamic equilibrium between these species were investigated by means of gas-phase electron diffraction (GED) and quantum chemical calculations up to MP2(full)/SDB-AUG-CC-pVTZ level of theory (MP2). According to electron diffraction data, the vapor of this compound comprises a mixture of conformers with chair conformation and Cs symmetry differing in the axial and equatorial position of the Si-I bond (axial = 73(7) mol%/equatorial = 27(7) mol%) at T = 352 K. This corresponds to a free energy difference of A = -0.59(22) kcal mol-1. The observed gas-phase electron diffraction parameters are in good agreement with those obtained from theory. NBO analysis revealed that axial conformer of 1-iodo-1-silacyclohexane is an example for electrostatic stabilization of a conformer which is unfavorable in terms of steric and conjugation interaction.

  12. Replacement between conformity and counter-conformity in consumption decisions.

    PubMed

    Chou, Ting-Jui; Chang, En-Chung; Dai, Qi; Wong, Veronica

    2013-02-01

    This study assessed, in a Chinese context, how self-esteem interacts with perceived similarity and uniqueness to yield cognitive dissonance, and whether the dissonance leads to self-reported conformity or counter-conformity behavior. Participants were 408 respondents from 4 major Chinese cities (M age = 33.0 yr., SD = 4.3; 48% men). Self-perceptions of uniqueness, similarity, cognitive dissonance, self-esteem and need to behave in conformity or counter-conformity were measured. A theoretical model was assessed in four situations, relating the ratings of self-esteem and perceived similarity/uniqueness to the way other people at a wedding were dressed, and the resultant cognitive dissonance and conformity/ counter-conformity behavior. Regardless of high or low self-esteem, all participants reported cognitive dissonance when they were told that they were dressed extremely similarly to or extremely differently from the other people attending the wedding. However, the conforming/counter-conforming strategies used by participants to resolve the cognitive dissonance differed. When encountering dissonance induced by the perceived extreme uniqueness of dress, participants with low self-esteem tended to say they would dress next time so as to conform with the way others were dressed, while those with high self-esteem indicated they would continue their counter-conformity in attire. When encountering dissonance induced by the perceived extreme similarity to others, both those with high and low self-esteem tended to say they would dress in an unorthodox manner to surprise other people in the future. PMID:23654033

  13. Multiple Conformations of E. Coli Hsp90 in Solution: Insights Into the Conformational Dynamics of Hsp90

    SciTech Connect

    Krukenberg, K.A.; Forster, F.; Rice, L.M.; Sali, A.; Agard, D.A.

    2009-05-20

    Hsp90, an essential eukaryotic chaperone, depends upon its intrinsic ATPase activity for function. Crystal structures of the bacterial Hsp90 homolog, HtpG, and the yeast Hsp90 reveal large domain rearrangements between the nucleotide-free and the nucleotide-bound forms. We used small-angle X-ray scattering and recently developed molecular modeling methods to characterize the solution structure of HtpG and demonstrate how it differs from known Hsp90 conformations. In addition to this HtpG conformation, we demonstrate that under physiologically relevant conditions, multiple conformations coexist in equilibrium. In solution, nucleotide-free HtpG adopts a more extended conformation than observed in the crystal, and upon the addition of AMPPNP, HtpG is in equilibrium between this open state and a closed state that is in good agreement with the yeast AMPPNP crystal structure. These studies provide a unique view of Hsp90 conformational dynamics and provide a model for the role of nucleotide in effecting conformational change.

  14. A study into the effects of protein binding on nucleotide conformation.

    PubMed Central

    Moodie, S L; Thornton, J M

    1993-01-01

    In this study, we examine the effects of binding to protein upon nucleotide conformation, by the comparison of X-ray crystal structures of free and protein-bound nucleotides. A dataset of structurally non-homologous protein-nucleotide complexes was derived from the Brookhaven Protein Data Bank by a novel protocol of dual sequential and structural alignments, and a dataset of native nucleotide structures was obtained from the Cambridge Structural Database. The nucleotide torsion angles and sugar puckers, which describe nucleotide conformation, were analysed in both datasets and compared. Differences between them are described and discussed. Overall, the nucleotides were found to bind in low energy conformations, not significantly different from their 'free' conformations except that they adopted an extended conformation in preference to the 'closed' structure predominantly observed by free nucleotide. The archetypal conformation of a protein-bound nucleotide is derived from these observations. PMID:8464727

  15. Classical Virasoro irregular conformal block

    NASA Astrophysics Data System (ADS)

    Rim, Chaiho; Zhang, Hong

    2015-07-01

    Virasoro irregular conformal block with arbitrary rank is obtained for the classical limit or equivalently Nekrasov-Shatashvili limit using the beta-deformed irregular matrix model (Penner-type matrix model for the irregular conformal block). The same result is derived using the generalized Mathieu equation which is equivalent to the loop equation of the irregular matrix model.

  16. Conformal gravity and time

    NASA Astrophysics Data System (ADS)

    Hazboun, Jeffrey Shafiq

    2014-10-01

    Cartan geometry provides a rich formalism from which to look at various geometrically motivated extensions to general relativity. In this manuscript, we start by motivating reasons to extend the theory of general relativity. We then introduce the reader to our technique, called the quotient manifold method, for extending the geometry of spacetime. We will specifically look at the class of theories formed from the various quotients of the conformal group. Starting with the conformal symmetries of Euclidean space, we construct a manifold where time manifests as a part of the geometry. Though there is no matter present in the geome- try studied here, geometric terms analogous to dark energy and dark matter appear when we write down the Einstein tensor. Specifically, the quotient of the conformal group of Euclidean four-space by its Weyl subgroup results in a geometry possessing many of the properties of relativistic phase space, including both a natural symplectic form and nondegenerate Killing metric. We show the general solution possesses orthogonal Lagrangian submanifolds, with the induced metric and the spin connection on the submanifolds necessarily Lorentzian, despite the Euclidean starting point. By examining the structure equations of the biconformal space in an orthonormal frame adapted to its phase space properties, we also find two new tensor fields exist in this geometry, not present in Riemannian geometry. The first is a combination of the Weyl vector with the scale factor on the metric, and determines the time-like directions on the submanifolds. The second comes from the components of the spin connection, symmetric with respect to the new metric. Though this field comes from the spin connection, it transforms ho- mogeneously. Finally, we show in the absence of Cartan curvature or sources, the configuration space has geometric terms equivalent to a perfect fluid and a cosmological constant. We complete the analysis of this homogeneous space by

  17. Projectors, shadows, and conformal blocks

    NASA Astrophysics Data System (ADS)

    Simmons-Duffin, David

    2014-04-01

    We introduce a method for computing conformal blocks of operators in arbitrary Lorentz representations in any spacetime dimension, making it possible to apply bootstrap techniques to operators with spin. The key idea is to implement the "shadow formalism" of Ferrara, Gatto, Grillo, and Parisi in a setting where conformal invariance is manifest. Conformal blocks in d-dimensions can be expressed as integrals over the projective null-cone in the "embedding space" d+1,1. Taking care with their analytic structure, these integrals can be evaluated in great generality, reducing the computation of conformal blocks to a bookkeeping exercise. To facilitate calculations in four-dimensional CFTs, we introduce techniques for writing down conformally-invariant correlators using auxiliary twistor variables, and demonstrate their use in some simple examples.

  18. The Henry Cecil Ranson McBay Chair in Space Science

    NASA Technical Reports Server (NTRS)

    Bota, Kofi B.; King, James, Jr.

    1999-01-01

    The goals and objectives of the Henry Cecil Ransom McBay Chair in Space Sciences were to: (1) provide leadership in developing and expanding Space Science curriculum; (2) contribute to the research and education endeavors of NASA's Mission to Planet Earth program; (3) expand opportunities for education and hands-on research in Space and Earth Sciences; (4) enhance scientific and technological literacy at all educational levels and to increase awareness of opportunities in the Space Sciences; and (5) develop a pipeline, starting with high school, of African American students who will develop into a cadre of well-trained scientists with interest in Space Science Research and Development.

  19. Personality disorders in adopted versus non-adopted adults.

    PubMed

    Westermeyer, Joseph; Yoon, Gihyun; Amundson, Carla; Warwick, Marion; Kuskowski, Michael A

    2015-04-30

    The goal of this epidemiological study was to investigate lifetime history and odds ratios of personality disorders in adopted and non-adopted adults using a nationally representative sample. Data, drawn from the National Epidemiological Survey on Alcohol and Related Conditions (NESARC), were compared in adopted (n=378) versus non-adopted (n=42,503) adults to estimate the odds of seven personality disorders using logistic regression analyses. The seven personality disorders were histrionic, antisocial, avoidant, paranoid, schizoid, obsessive-compulsive, and dependent personality disorder. Adoptees had a 1.81-fold increase in the odds of any personality disorder compared with non-adoptees. Adoptees had increased odds of histrionic, antisocial, avoidant, paranoid, schizoid, and obsessive-compulsive personality disorder compared with non-adoptees. Two risk factors associated with lifetime history of a personality disorder in adoptees compared to non-adoptees were (1) being in the age cohort 18-29 years (but no difference in the age 30-44 cohort), using the age 45 or older cohort as the reference and (2) having 12 years of education (but no difference in higher education groups), using the 0-11 years of education as the reference. These findings support the higher rates of personality disorders among adoptees compared to non-adoptees. PMID:25752207

  20. Warped conformal field theory

    NASA Astrophysics Data System (ADS)

    Detournay, Stéphane; Hartman, Thomas; Hofman, Diego M.

    2012-12-01

    We study field theories in two spacetime dimensions invariant under a chiral scaling symmetry that acts only on right-movers. The local symmetries include one copy of the Virasoro algebra and a U(1) current algebra. This differs from the two-dimensional conformal group but in some respects is equally powerful in constraining the theory. In particular, the symmetries on a torus lead to modular covariance of the partition function, which is used to derive a universal formula for the asymptotic density of states. For an application we turn to the holographic description of black holes in quantum gravity, motivated by the fact that the symmetries in the near-horizon geometry of any extremal black hole are identical to those of a two-dimensional field theory with chiral scaling. We consider two examples: black holes in warped AdS3 in topologically massive gravity and in string theory. In both cases, the density of states in the two-dimensional field theory reproduces the Bekenstein-Hawking entropy of black holes in the gravity theory.

  1. Dynamics of protein conformations

    NASA Astrophysics Data System (ADS)

    Stepanova, Maria

    2010-10-01

    A novel theoretical methodology is introduced to identify dynamic structural domains and analyze local flexibility in proteins. The methodology employs a multiscale approach combining identification of essential collective coordinates based on the covariance analysis of molecular dynamics trajectories, construction of the Mori projection operator with these essential coordinates, and analysis of the corresponding generalized Langevin equations [M.Stepanova, Phys.Rev.E 76(2007)051918]. Because the approach employs a rigorous theory, the outcomes are physically transparent: the dynamic domains are associated with regions of relative rigidity in the protein, whereas off-domain regions are relatively soft. This also allows scoring the flexibility in the macromolecule with atomic-level resolution [N.Blinov, M.Berjanskii, D.S.Wishart, and M.Stepanova, Biochemistry, 48(2009)1488]. The applications include the domain coarse-graining and characterization of conformational stability in protein G and prion proteins. The results are compared with published NMR experiments. Potential applications for structural biology, bioinformatics, and drug design are discussed.

  2. Re an Adoption Application (Surrogacy)

    PubMed

    1987-03-01

    In England, it is illegal under the Adoption Act 1958 to pay or reward anyone in an effort to adopt a child. A family court was asked in this case whether a surrogacy arrangement involving the payment of 5,000 pounds violated the Act. The applicants, a husband and wife, were unable to have children and had entered into an informal arrangement with a woman who agreed to engage in sexual intercourse with the husband and bear a child for the couple in exchange for 10,000 pounds. Because the surrogate wrote a book about her experience from which she made money, and sincerely wanted to help out the childless couple, she accepted only half of her fee. Convinced that the surrogate arrangement was not commercial in nature, the court found no violation of English law, authorized the payment to the mother, and authorized adoption of the child by the father and his wife. PMID:11648176

  3. Two quinazolinones: a ring conformational study.

    PubMed

    Swamy, G Y S K; Sridhar, B; Ravikumar, K; Sadanandam, Y S

    2008-02-01

    The molecules of (+/-)-2-(4-methoxyphenyl)-1-phenethyl-2,3-dihydroquinazolin-4(1H)-one, C(23)H(22)N(2)O(2), (I), and (+/-)-2-(1,3-benzodioxol-5-yl)-1-phenethyl-2,3-dihydroquinazolin-4(1H)-one, C(23)H(20)N(2)O(3), (II), have T-shaped forms in the crystal structure. The tetrahydropyrimidine ring in both structures adopts a sofa conformation. Both molecules are linked by N-H...O and C-H...O hydrogen bonds to form sheets built from alternating R(2)(2)(8) and R(4)(4)(26) [R(4)(4)(24) in (II)] edge-fused rings. Additionally, the structures are stabilized by extensive C-H...pi interactions. PMID:18253014

  4. Determinants of internet poker adoption.

    PubMed

    Philander, Kahlil S; Abarbanel, B Lillian

    2014-09-01

    In nearly all jurisdictions, adoption of a new form of gambling has been a controversial and contentious subject. Online gambling has been no different, though there are many aspects that affect online gambling that do not appear in the brick and mortar environment. This study seeks to identify whether demographic, economic, political, technological, and/or sociological determinants contribute to online poker gambling adoption. A theoretical discussion of these categories' importance to online poker is provided and exploratory empirical analysis is used to examine their potential validity. The analysis revealed support for all of the proposed categories of variables thought to be predictive of online gambling legality. PMID:23661279

  5. Molecular mechanics approach for design and conformational studies of macrocyclic ligands

    NASA Astrophysics Data System (ADS)

    Rohini, Akbar, Rifat; Kanungo, B. K.

    2015-08-01

    Computational Chemistry has revolutionized way of viewing molecules at the quantum mechanical scale by allowing simulating various chemical scenarios that are not possible to study in a laboratory. The remarkable applications of computational chemistry have promoted to design and test of the effectiveness of various methods for searching the conformational space of highly flexible molecules. In this context, we conducted a series of optimization and conformational searches on macrocyclic based ligands, 9N3Me5Ox, (1,4,7-tris(5-methyl-8-hydroxyquinoline)-1,4,7-triazacyclononane) and 12N3Me5Ox, (1,5,9-tris(5-methyl-8-hydroxyquinoline)-1,5,9-triazacyclododecane) and studied their selectivity and coordination behavior with some lanthanide metal ions in molecular mechanics and semiempirical methods. The methods include both systematic and random conformational searches for dihedral angles, torsion angles and Cartesian coordinates. Structural studies were carried out by using geometry optimization, coordination scans and electronic properties were evaluated. The results clearly show that chair-boat conformational isomer of 9N3Me5Ox ligand is more stable due to lower eclipsing ethane interaction and form stronger adduct complexes with lanthanide metal ion. This is because of the fact that, in a central unit of 9N3 of the ligand form six endo type bonds out of nine. The rest of bonds have trans conformation. In contrast, for the adduct of 12N3Me5Ox, two C-C bonds have on eclipsed conformation, and others have synclinal and antiperiplanar confirmations. The distortion of the two eclipsed conformations may affect the yields and the stability of the complexes.

  6. Molecular mechanics approach for design and conformational studies of macrocyclic ligands

    SciTech Connect

    Rohini,; Akbar, Rifat; Kanungo, B. K.

    2015-08-28

    Computational Chemistry has revolutionized way of viewing molecules at the quantum mechanical scale by allowing simulating various chemical scenarios that are not possible to study in a laboratory. The remarkable applications of computational chemistry have promoted to design and test of the effectiveness of various methods for searching the conformational space of highly flexible molecules. In this context, we conducted a series of optimization and conformational searches on macrocyclic based ligands, 9N3Me5Ox, (1,4,7-tris(5-methyl-8-hydroxyquinoline)-1,4,7-triazacyclononane) and 12N3Me5Ox, (1,5,9-tris(5-methyl-8-hydroxyquinoline)-1,5,9-triazacyclododecane) and studied their selectivity and coordination behavior with some lanthanide metal ions in molecular mechanics and semiempirical methods. The methods include both systematic and random conformational searches for dihedral angles, torsion angles and Cartesian coordinates. Structural studies were carried out by using geometry optimization, coordination scans and electronic properties were evaluated. The results clearly show that chair-boat conformational isomer of 9N3Me5Ox ligand is more stable due to lower eclipsing ethane interaction and form stronger adduct complexes with lanthanide metal ion. This is because of the fact that, in a central unit of 9N3 of the ligand form six endo type bonds out of nine. The rest of bonds have trans conformation. In contrast, for the adduct of 12N3Me5Ox, two C-C bonds have on eclipsed conformation, and others have synclinal and antiperiplanar confirmations. The distortion of the two eclipsed conformations may affect the yields and the stability of the complexes.

  7. Adoption Failure: A Social Work Postmortem

    ERIC Educational Resources Information Center

    Kadushin, Alfred; Seidl, Frederick W.

    1971-01-01

    Failed adoption is defined as removal of the adoptive child at any time between placement and legal adoption. A study of failed adoptions in a statewide adoption agency found a failure rate of less than 3 percent. Reasons for failure are analyzed and implications for practice are suggested. (Author)

  8. Canadian Adoption Statistics: 1981-1990.

    ERIC Educational Resources Information Center

    Sobol, Michael P.; Daly, Kerry J.

    1994-01-01

    Obtained data on Canadian adoptions (1981-90) from adoption coordinators of all 10 provinces and 2 territories. Found downward trends in use of adoption as means of family formation across decade. By 1990, most infant adoptions were facilitated by private practitioners and agencies whereas older children were primarily adopted through public…

  9. Towards conformal loop quantum gravity

    NASA Astrophysics Data System (ADS)

    H-T Wang, Charles

    2006-03-01

    A discussion is given of recent developments in canonical gravity that assimilates the conformal analysis of gravitational degrees of freedom. The work is motivated by the problem of time in quantum gravity and is carried out at the metric and the triad levels. At the metric level, it is shown that by extending the Arnowitt-Deser-Misner (ADM) phase space of general relativity (GR), a conformal form of geometrodynamics can be constructed. In addition to the Hamiltonian and Diffeomorphism constraints, an extra first class constraint is introduced to generate conformal transformations. This phase space consists of York's mean extrinsic curvature time, conformal three-metric and their momenta. At the triad level, the phase space of GR is further enlarged by incorporating spin-gauge as well as conformal symmetries. This leads to a canonical formulation of GR using a new set of real spin connection variables. The resulting gravitational constraints are first class, consisting of the Hamiltonian constraint and the canonical generators for spin-gauge and conformorphism transformations. The formulation has a remarkable feature of being parameter-free. Indeed, it is shown that a conformal parameter of the Barbero-Immirzi type can be absorbed by the conformal symmetry of the extended phase space. This gives rise to an alternative approach to loop quantum gravity that addresses both the conceptual problem of time and the technical problem of functional calculus in quantum gravity.

  10. Logarithmic conformal field theory

    NASA Astrophysics Data System (ADS)

    Gainutdinov, Azat; Ridout, David; Runkel, Ingo

    2013-12-01

    Conformal field theory (CFT) has proven to be one of the richest and deepest subjects of modern theoretical and mathematical physics research, especially as regards statistical mechanics and string theory. It has also stimulated an enormous amount of activity in mathematics, shaping and building bridges between seemingly disparate fields through the study of vertex operator algebras, a (partial) axiomatisation of a chiral CFT. One can add to this that the successes of CFT, particularly when applied to statistical lattice models, have also served as an inspiration for mathematicians to develop entirely new fields: the Schramm-Loewner evolution and Smirnov's discrete complex analysis being notable examples. When the energy operator fails to be diagonalisable on the quantum state space, the CFT is said to be logarithmic. Consequently, a logarithmic CFT is one whose quantum space of states is constructed from a collection of representations which includes reducible but indecomposable ones. This qualifier arises because of the consequence that certain correlation functions will possess logarithmic singularities, something that contrasts with the familiar case of power law singularities. While such logarithmic singularities and reducible representations were noted by Rozansky and Saleur in their study of the U (1|1) Wess-Zumino-Witten model in 1992, the link between the non-diagonalisability of the energy operator and logarithmic singularities in correlators is usually ascribed to Gurarie's 1993 article (his paper also contains the first usage of the term 'logarithmic conformal field theory'). The class of CFTs that were under control at this time was quite small. In particular, an enormous amount of work from the statistical mechanics and string theory communities had produced a fairly detailed understanding of the (so-called) rational CFTs. However, physicists from both camps were well aware that applications from many diverse fields required significantly more

  11. Characteristics of highly successful orthopedic surgeons: a survey of orthopedic chairs and editors

    PubMed Central

    Klein, Guy; Hussain, Nasir; Sprague, Sheila; Mehlman, Charles T.; Dogbey, Godwin; Bhandari, Mohit

    2013-01-01

    Background Highly successful orthopedic surgeons are a small group of individuals who exert a large influence on the orthopedic field. However, the characteristics of these leaders have not been well-described or studied. Methods Orthopedic surgeons who are departmental chairs, journal editors, editorial board members of the Journal of Bone and Joint Surgery (British edition), or current or past presidents of major orthopedic associations were invited to complete a survey designed to provide insight into their motivations, academic backgrounds and accomplishments, emotional and physical health, and job satisfaction. Results In all, 152 surgeons completed the questionnaire. We identified several characteristics of highly successful surgeons. Many have contributed prolific numbers of publications and book chapters and obtained considerable funding for research. They were often motivated by a “desire for personal development (interesting challenge, new opportunities),” whereas “relocating to a new institution, financial gain, or lack of alternative candidates” played little to no role in their decisions to take positions of leadership. Most respondents were happy with their specialty choice despite long hours and high levels of stress. Despite challenges to their time, successful orthopedic surgeons made a strong effort to maintain their health; compared with other physicians, they exercise more, are more likely to have a primary care physician and feel better physically. Conclusion Departmental chairs, journal editors and presidents of orthopedic associations cope with considerable demands of clinical, administrative, educational and research duties while maintaining a high level of health, happiness and job satisfaction. PMID:23706848

  12. Different Brain Responses to Pain and Its Expectation in the Dental Chair.

    PubMed

    Racek, A J; Hu, X; Nascimento, T D; Bender, M C; Khatib, L; Chiego, D; Holland, G R; Bauer, P; McDonald, N; Ellwood, R P; DaSilva, A F

    2015-07-01

    A dental appointment commonly prompts fear of a painful experience, yet we have never fully understood how our brains react to the expectation of imminent tooth pain once in a dental chair. In our study, 21 patients with hypersensitive teeth were tested using nonpainful and painful stimuli in a clinical setting. Subjects were tested in a dental chair using functional near-infrared spectroscopy to measure cortical activity during a stepwise cold stimulation of a hypersensitive tooth, as well as nonpainful control stimulation on the same tooth. Patients' sensory-discriminative and emotional-cognitive cortical regions were studied through the transition of a neutral to a painful stimulation. In the putative somatosensory cortex contralateral to the stimulus, 2 well-defined hemodynamic peaks were detected in the homuncular orofacial region: the first peak during the nonpainful phase and a second peak after the pain threshold was reached. Moreover, in the upper-left and lower-right prefrontal cortices, there was a significant active hemodynamic response in only the first phase, before the pain. Subsequently, the same prefrontal cortical areas deactivated after a painful experience had been reached. Our study indicates for the first time that pain perception and expectation elicit different hemodynamic cortical responses in a dental clinical setting. PMID:25904140

  13. A smart health monitoring chair for nonintrusive measurement of biological signals.

    PubMed

    Baek, Hyun Jae; Chung, Gih Sung; Kim, Ko Keun; Park, Kwang Suk

    2012-01-01

    We developed nonintrusive methods for simultaneous electrocardiogram, photoplethysmogram, and ballistocardiogram measurements that do not require direct contact between instruments and bare skin. These methods were applied to the design of a diagnostic chair for unconstrained heart rate and blood pressure monitoring purposes. Our methods were operationalized through capacitively coupled electrodes installed in the chair back that include high-input impedance amplifiers, and conductive textiles installed in the seat for capacitive driven-right-leg circuit configuration that is capable of recording electrocardiogram information through clothing. Photoplethysmograms were measured through clothing using seat mounted sensors with specially designed amplifier circuits that vary in light intensity according to clothing type. Ballistocardiograms were recorded using a film type transducer material, polyvinylidenefluoride (PVDF), which was installed beneath the seat cover. By simultaneously measuring signals, beat-to-beat heart rates could be monitored even when electrocardiograms were not recorded due to movement artifacts. Beat-to-beat blood pressure was also monitored using unconstrained measurements of pulse arrival time and other physiological parameters, and our experimental results indicated that the estimated blood pressure tended to coincide with actual blood pressure measurements. This study demonstrates the feasibility of our method and device for biological signal monitoring through clothing for unconstrained long-term daily health monitoring that does not require user awareness and is not limited by physical activity. PMID:22086543

  14. Are pressure measurements effective in the assessment of office chair comfort/discomfort? A review.

    PubMed

    Zemp, Roland; Taylor, William R; Lorenzetti, Silvio

    2015-05-01

    Nowadays, the majority of jobs in the western world involves sitting in an office chair. As a result, a comfortable and supported sitting position is essential for employees. In the literature, various objective methods (e.g. pressure measurements, measurements of posture, EMG etc.) have been used to assess sitting comfort/discomfort, but their validity remains unknown. This review therefore examines the relationship between subjective comfort/discomfort and pressure measurements while sitting in office chairs. The literature search resulted in eight papers that met all our requirements. Four studies identified a relationship between subjective comfort/discomfort and pressure distribution parameters (including correlations of up to r = 0.7 ± 0.13). However, the technique for evaluating subjective comfort/discomfort seems to play an important role on the results achieved, therefore placing their validity into question. The peak pressure on the seat pan, the pressure distribution on the backrest and the pressure pattern changes (seat pan and backrest) all appear to be reliable measures for quantifying comfort or discomfort. PMID:25683554

  15. Physiological Motion Axis for the Seat of a Dynamic Office Chair

    PubMed Central

    Kuster, Roman Peter; Bauer, Christoph Markus; Oetiker, Sarah; Kool, Jan

    2016-01-01

    Objective The aim of this study was to determine and verify the optimal location of the motion axis (MA) for the seat of a dynamic office chair. Background A dynamic seat that supports pelvic motion may improve physical well-being and decrease the risk of sitting-associated disorders. However, office work requires an undisturbed view on the work task, which means a stable position of the upper trunk and head. Current dynamic office chairs do not fulfill this need. Consequently, a dynamic seat was adapted to the physiological kinematics of the human spine. Method Three-dimensional motion tracking in free sitting helped determine the physiological MA of the spine in the frontal plane. Three dynamic seats with physiological, lower, and higher MA were compared in stable upper body posture (thorax inclination) and seat support of pelvic motion (dynamic fitting accuracy). Spinal kinematics during sitting and walking were compared. Results The physiological MA was at the level of the 11th thoracic vertebra, causing minimal thorax inclination and high dynamic fitting accuracy. Spinal motion in active sitting and walking was similar. Conclusion The physiological MA of the seat allows considerable lateral flexion of the spine similar to walking with a stable upper body posture and a high seat support of pelvic motion. Application The physiological MA enables lateral flexion of the spine, similar to walking, without affecting stable upper body posture, thus allowing active sitting while focusing on work. PMID:27150530

  16. Jean-Martin Charcot and his vibratory chair for Parkinson disease.

    PubMed

    Goetz, Christopher G

    2009-08-11

    Vibration therapy is currently used in diverse medical specialties ranging from orthopedics to urology to sports medicine. The celebrated 19th-century neurologist, J.-M. Charcot, used vibratory therapy to treat Parkinson disease (PD). This study analyzed printed writings by Charcot and other writers on vibratory therapy and accessed unpublished notes from the Salpêtrière Hospital, Paris. Charcot lectured on several occasions on vibratory therapy and its neurologic applications. He developed a vibration chair for patients with PD after he observed that patients were more comfortable and slept better after a train or carriage ride. He replicated this experience by having patients undergo daily 30-minute sessions in the automated vibratory chair (fauteuil trépidant). His junior colleague, Gilles de la Tourette, extended these observations and developed a helmet that vibrated the head on the premise that the brain responded directly to the pulsations. Although after Charcot's death vibratory therapy was not widely pursued, vibratory appliances are reemerging in 21st century medicine and can be retested using adaptations of Charcot's neurologic protocols. PMID:19667323

  17. Simulation of a Congress at the Chair of Biology II in Bioengineering

    NASA Astrophysics Data System (ADS)

    Naranjo, A. V.; Reznichenco, V.; López, N.; Hernández, R.; Bajinay, S.

    2007-11-01

    This work has been developed in the Chair of Biology II, the curricular contents of which correspond to Human Anatomy. This subject is taught in the second semester of the second year of studies in Bioengineering. Our main objective is that the students attending the course may integrate the syllabus contents of Anatomy with those of other subjects in the career. Ever since 1998 we have organized a congress named Congreso Intracátedra de Biología II (Intra Chair Congress on Biology II). This is the last assignment in the semester and is compulsory for regular students of the subject. It consists in simulating a scientific congress with international characteristics. The guidelines for the congress are made known to the students at the beginning of the semester. In groups of up to three members, the students must undertake a work that relates aspects of Anatomy with Bioengineering. Students are expected to investigate on diagnostic and/or therapeutic technology in order to write a paper that must be accepted in advance of the event. The presentation of the work must be made through PowerPoint. The originality of the research work done and the wide range of topics selected are surprising. Problems are tackled from the standpoints both of the various medical fields and of bioengineering despite the fact that they are just students of the second year in Bioengineering.

  18. CONFORMANCE IMPROVEMENT USING GELS

    SciTech Connect

    Randall S. Seright

    2002-02-28

    This technical progress report describes work performed from June 20 through December 19, 2001, for the project, ''Conformance Improvement Using Gels''. Interest has increased in some new polymeric products that purport to substantially reduce permeability to water while causing minimum permeability reduction to oil. In view of this interest, we are currently studying BJ's Aqua Con. Results from six corefloods revealed that the Aqua Con gelant consistently reduced permeability to water more than that to oil. However, the magnitude of the disproportionate permeability reduction varied significantly for the various experiments. Thus, as with most materials tested to date, the issue of reproducibility and control of the disproportionate permeability remains to be resolved. Concern exists about the ability of gels to resist washout after placement in fractures. We examined whether a width constriction in the middle of a fracture would cause different gel washout behavior upstream versus downstream of the constriction. Tests were performed using a formed Cr(III)-acetate-HPAM gel in a 48-in.-long fracture with three sections of equal length, but with widths of 0.08-, 0.02-, and 0.08-in., respectively. The pressure gradients during gel extrusion (i.e., placement) were similar in the two 0.08-in.-wide fracture sections, even though they were separated by a 0.02-in.-wide fracture section. The constriction associated with the middle fracture section may have inhibited gel washout during the first pulse of brine injection after gel placement. However, during subsequent phases of brine injection, the constriction did not inhibit washout in the upstream fracture section any more than in the downstream section.

  19. Why Adoption of Standards Matters

    ERIC Educational Resources Information Center

    Journal of Staff Development, 2016

    2016-01-01

    A total of 39 states have adopted, adapted, or endorsed the Standards for Professional Learning, including the standards issued in 2011 (labeled in red) and those published earlier (labeled in blue). Making a commitment to the standards is a commitment to continuous learning for all educators in a school.

  20. Internet Adoption: An Empirical Investigation

    ERIC Educational Resources Information Center

    Ma, Junzhao

    2011-01-01

    The Internet has brought significant changes to the retail industry because it revolutionizes how information is transmitted and accessed. The main objective of this research is to enhance our understanding of people's adoption of the Internet and its implications for retail competition. This dissertation consists of two essays. The first essay…

  1. Has the Academy Adopted TQM?

    ERIC Educational Resources Information Center

    Birnbaum, Robert; Deshotels, Judy

    1999-01-01

    A survey of 469 colleges and universities assessed the degree to which colleges and universities have adopted total quality management (TQM) or continuous quality improvement (CQI) techniques. Results suggest use of TQM/CQI is lower than predicted, at about 13% of institutions. Variations in extent of use of the approach are discussed. (MSE)

  2. Adoptive immunotherapy against ovarian cancer.

    PubMed

    Mittica, Gloria; Capellero, Sonia; Genta, Sofia; Cagnazzo, Celeste; Aglietta, Massimo; Sangiolo, Dario; Valabrega, Giorgio

    2016-01-01

    The standard front-line therapy for epithelial ovarian cancer (EOC) is combination of debulking surgery and platinum-based chemotherapy. Nevertheless, the majority of patients experience disease recurrence. Although extensive efforts to find new therapeutic options, cancer cells invariably develop drug resistance and disease progression. New therapeutic strategies are needed to improve prognosis of patients with advanced EOC.Recently, several preclinical and clinical studies investigated feasibility and activity of adoptive immunotherapy in EOC. Our aim is to highlight prospective of adoptive immunotherapy in EOC, focusing on HLA-restricted Tumor Infiltrating Lymphocytes (TILs), and MHC-independent immune effectors such as natural killer (NK), and cytokine-induced killer (CIK). Adoptive cell therapy (ACT) has shown activity in several pre-clinical models. Available preclinical and clinical data suggest that adoptive cell therapy may provide the best benefit in settings of low tumor burden, minimal residual disease, or maintenance therapy. Further studies are needed to better define the optimal clinical setting. PMID:27188274

  3. Adoption Issues, Trends and Networking.

    ERIC Educational Resources Information Center

    Pierce, William L.

    Teenage women with unplanned pregnancies constitute one of America's greatest challenges in terms of providing good services and sound counseling on options. Only about 7% of teenagers having babies make alternate childrearing plans either through formal adoption or informally with members of their families. The emphasis on making teenagers good…

  4. Conformational changes of adsorbed proteins

    NASA Astrophysics Data System (ADS)

    Allen, Scott

    2005-03-01

    The adsorption of bovine serum albumin (BSA) and pepsin to gold surfaces has been studied using surface plasmon resonance (SPR). Proteins are adsorbed from solution onto a gold surface and changes in the conformation of the adsorbed proteins are induced by changing the buffer solution. We selected pH and ionic strength values for the buffer solutions that are known from our circular dichroism measurements to cause conformational changes of the proteins in bulk solution. We find that for both BSA and pepsin the changes in conformation are impeded by the interaction of the protein with the gold surface.

  5. Pressure-induced conformational switch of an interfacial protein.

    PubMed

    Johnson, Quentin R; Lindsay, Richard J; Nellas, Ricky B; Shen, Tongye

    2016-06-01

    A special class of proteins adopts an inactive conformation in aqueous solution and activates at an interface (such as the surface of lipid droplet) by switching their conformations. Lipase, an essential enzyme for breaking down lipids, serves as a model system for studying such interfacial proteins. The underlying conformational switch of lipase induced by solvent condition is achieved through changing the status of the gated substrate-access channel. Interestingly, a lipase was also reported to exhibit pressure activation, which indicates it is drastically active at high hydrostatic pressure. To unravel the molecular mechanism of this unusual phenomenon, we examined the structural changes induced by high hydrostatic pressures (up to 1500 MPa) using molecular dynamics simulations. By monitoring the width of the access channel, we found that the protein undergoes a conformational transition and opens the access channel at high pressures (>100 MPa). Particularly, a disordered amphiphilic α5 region of the protein becomes ordered at high pressure. This positive correlation between the channel opening and α5 ordering is consistent with the early findings of the gating motion in the presence of a water-oil interface. Statistical analysis of the ensemble of conformations also reveals the essential collective motions of the protein and how these motions contribute to gating. Arguments are presented as to why heightened sensitivity to high-pressure perturbation can be a general feature of switchable interfacial proteins. Further mutations are also suggested to validate our observations. Proteins 2016; 84:820-827. © 2016 Wiley Periodicals, Inc. PMID:26967808

  6. Conformational states of the full-length glucagon receptor

    NASA Astrophysics Data System (ADS)

    Yang, Linlin; Yang, Dehua; de Graaf, Chris; Moeller, Arne; West, Graham M.; Dharmarajan, Venkatasubramanian; Wang, Chong; Siu, Fai Y.; Song, Gaojie; Reedtz-Runge, Steffen; Pascal, Bruce D.; Wu, Beili; Potter, Clinton S.; Zhou, Hu; Griffin, Patrick R.; Carragher, Bridget; Yang, Huaiyu; Wang, Ming-Wei; Stevens, Raymond C.; Jiang, Hualiang

    2015-07-01

    Class B G protein-coupled receptors are composed of an extracellular domain (ECD) and a seven-transmembrane (7TM) domain, and their signalling is regulated by peptide hormones. Using a hybrid structural biology approach together with the ECD and 7TM domain crystal structures of the glucagon receptor (GCGR), we examine the relationship between full-length receptor conformation and peptide ligand binding. Molecular dynamics (MD) and disulfide crosslinking studies suggest that apo-GCGR can adopt both an open and closed conformation associated with extensive contacts between the ECD and 7TM domain. The electron microscopy (EM) map of the full-length GCGR shows how a monoclonal antibody stabilizes the ECD and 7TM domain in an elongated conformation. Hydrogen/deuterium exchange (HDX) studies and MD simulations indicate that an open conformation is also stabilized by peptide ligand binding. The combined studies reveal the open/closed states of GCGR and suggest that glucagon binds to GCGR by a conformational selection mechanism.

  7. Conformation and interactions of dopamine hydrochloride in solution

    SciTech Connect

    Callear, Samantha K.; Imberti, Silvia; Johnston, Andrew; McLain, Sylvia E.

    2015-01-07

    The aqueous solution of dopamine hydrochloride has been investigated using neutron and X-ray total scattering data together with Monte-Carlo based modelling using Empirical Potential Structure Refinement. The conformation of the protonated dopamine molecule is presented and the results compared to the conformations found in crystal structures, dopamine-complexed protein crystal structures and predicted from theoretical calculations and pharmacophoric models. It is found that protonated dopamine adopts a range of conformations in solution, highlighting the low rotational energy barrier between different conformations, with the preferred conformation being trans-perpendicular. The interactions between each of the species present (protonated dopamine molecules, water molecules, and chloride anions) have been determined and are discussed with reference to interactions observed in similar systems both in the liquid and crystalline state, and predicted from theoretical calculations. The expected strong hydrogen bonds between the strong hydrogen bond donors and acceptors are observed, together with evidence of weaker CH hydrogen bonds and π interactions also playing a significant role in determining the arrangement of adjacent molecules.

  8. Conformational states of the full-length glucagon receptor

    PubMed Central

    Yang, Linlin; Yang, Dehua; de Graaf, Chris; Moeller, Arne; West, Graham M.; Dharmarajan, Venkatasubramanian; Wang, Chong; Siu, Fai Y.; Song, Gaojie; Reedtz-Runge, Steffen; Pascal, Bruce D.; Wu, Beili; Potter, Clinton S.; Zhou, Hu; Griffin, Patrick R.; Carragher, Bridget; Yang, Huaiyu; Wang, Ming-Wei; Stevens, Raymond C.; Jiang, Hualiang

    2015-01-01

    Class B G protein-coupled receptors are composed of an extracellular domain (ECD) and a seven-transmembrane (7TM) domain, and their signalling is regulated by peptide hormones. Using a hybrid structural biology approach together with the ECD and 7TM domain crystal structures of the glucagon receptor (GCGR), we examine the relationship between full-length receptor conformation and peptide ligand binding. Molecular dynamics (MD) and disulfide crosslinking studies suggest that apo-GCGR can adopt both an open and closed conformation associated with extensive contacts between the ECD and 7TM domain. The electron microscopy (EM) map of the full-length GCGR shows how a monoclonal antibody stabilizes the ECD and 7TM domain in an elongated conformation. Hydrogen/deuterium exchange (HDX) studies and MD simulations indicate that an open conformation is also stabilized by peptide ligand binding. The combined studies reveal the open/closed states of GCGR and suggest that glucagon binds to GCGR by a conformational selection mechanism. PMID:26227798

  9. The business of genomic testing: a survey of early adopters

    PubMed Central

    Crawford, James M.; Bry, Lynn; Pfeifer, John; Caughron, Samuel K.; Black-Schaffer, Stephen; Kant, Jeffrey A.; Kaufman, Jill H.

    2014-01-01

    Purpose: The practice of “genomic” (or “personalized”) medicine requires the availability of appropriate diagnostic testing. Our study objective was to identify the reasons for health systems to bring next-generation sequencing into their clinical laboratories and to understand the process by which such decisions were made. Such information may be of value to other health systems seeking to provide next-generation sequencing testing to their patient populations. Methods: A standardized open-ended interview was conducted with the laboratory medical directors and/or department of pathology chairs of 13 different academic institutions in 10 different states. Results: Genomic testing for cancer dominated the institutional decision making, with three primary reasons: more effective delivery of cancer care, the perceived need for institutional leadership in the field of genomics, and the premise that genomics will eventually be cost-effective. Barriers to implementation included implementation cost; the time and effort needed to maintain this newer testing; challenges in interpreting genetic variants; establishing the bioinformatics infrastructure; and curating data from medical, ethical, and legal standpoints. Ultimate success depended on alignment with institutional strengths and priorities and working closely with institutional clinical programs. Conclusion: These early adopters uniformly viewed genomic analysis as an imperative for developing their expertise in the implementation and practice of genomic medicine. PMID:25010053

  10. National Foster Care and Adoption Directory Search

    MedlinePlus

    ... Adoption Directory Search National Foster Care & Adoption Directory Search Many concerned individuals have expressed the desire to ... how to become a foster or adoptive parent. Search results for this category include contact information for: ...

  11. Logarithmic conformal field theory

    NASA Astrophysics Data System (ADS)

    Gainutdinov, Azat; Ridout, David; Runkel, Ingo

    2013-12-01

    Conformal field theory (CFT) has proven to be one of the richest and deepest subjects of modern theoretical and mathematical physics research, especially as regards statistical mechanics and string theory. It has also stimulated an enormous amount of activity in mathematics, shaping and building bridges between seemingly disparate fields through the study of vertex operator algebras, a (partial) axiomatisation of a chiral CFT. One can add to this that the successes of CFT, particularly when applied to statistical lattice models, have also served as an inspiration for mathematicians to develop entirely new fields: the Schramm-Loewner evolution and Smirnov's discrete complex analysis being notable examples. When the energy operator fails to be diagonalisable on the quantum state space, the CFT is said to be logarithmic. Consequently, a logarithmic CFT is one whose quantum space of states is constructed from a collection of representations which includes reducible but indecomposable ones. This qualifier arises because of the consequence that certain correlation functions will possess logarithmic singularities, something that contrasts with the familiar case of power law singularities. While such logarithmic singularities and reducible representations were noted by Rozansky and Saleur in their study of the U (1|1) Wess-Zumino-Witten model in 1992, the link between the non-diagonalisability of the energy operator and logarithmic singularities in correlators is usually ascribed to Gurarie's 1993 article (his paper also contains the first usage of the term 'logarithmic conformal field theory'). The class of CFTs that were under control at this time was quite small. In particular, an enormous amount of work from the statistical mechanics and string theory communities had produced a fairly detailed understanding of the (so-called) rational CFTs. However, physicists from both camps were well aware that applications from many diverse fields required significantly more

  12. Lattice Simulations and Infrared Conformality

    DOE PAGESBeta

    Appelquist, Thomas; Fleming, George T.; Lin, Meifeng; Neil, Ethan T.; Schaich, David A

    2011-09-01

    We examine several recent lattice-simulation data sets, asking whether they are consistent with infrared conformality. We observe, in particular, that for an SU(3) gauge theory with 12 Dirac fermions in the fundamental representation, recent simulation data can be described assuming infrared conformality. Lattice simulations include a fermion mass m which is then extrapolated to zero, and we note that this data can be fit by a small-m expansion, allowing a controlled extrapolation. We also note that the conformal hypothesis does not work well for two theories that are known or expected to be confining and chirally broken, and that itmore » does work well for another theory expected to be infrared conformal.« less

  13. Conformation Distributions in Adsorbed Proteins.

    NASA Astrophysics Data System (ADS)

    Meuse, Curtis W.; Hubbard, Joseph B.; Vrettos, John S.; Smith, Jackson R.; Cicerone, Marcus T.

    2007-03-01

    While the structural basis of protein function is well understood in the biopharmaceutical and biotechnology industries, few methods for the characterization and comparison of protein conformation distributions are available. New methods capable of measuring the stability of protein conformations and the integrity of protein-protein, protein-ligand and protein-surface interactions both in solution and on surfaces are needed to help the development of protein-based products. We are developing infrared spectroscopy methods for the characterization and comparison of molecular conformation distributions in monolayers and in solutions. We have extracted an order parameter describing the orientational and conformational variations of protein functional groups around the average molecular values from a single polarized spectrum. We will discuss the development of these methods and compare them to amide hydrogen/deuterium exchange methods for albumin in solution and on different polymer surfaces to show that our order parameter is related to protein stability.

  14. Lattice Simulations and Infrared Conformality

    SciTech Connect

    Appelquist, Thomas; Fleming, George T.; Lin, Meifeng; Neil, Ethan T.; Schaich, David A

    2011-09-01

    We examine several recent lattice-simulation data sets, asking whether they are consistent with infrared conformality. We observe, in particular, that for an SU(3) gauge theory with 12 Dirac fermions in the fundamental representation, recent simulation data can be described assuming infrared conformality. Lattice simulations include a fermion mass m which is then extrapolated to zero, and we note that this data can be fit by a small-m expansion, allowing a controlled extrapolation. We also note that the conformal hypothesis does not work well for two theories that are known or expected to be confining and chirally broken, and that it does work well for another theory expected to be infrared conformal.

  15. Arytenoid cartilage dislocation after reversed total shoulder replacement surgery in the beach chair position: a case report

    PubMed Central

    Sim, Yeo Hae; Choi, Jeong-Hyun

    2016-01-01

    Arytenoid cartilage dislocation is not a common complication, but its delayed diagnosis reduces the therapeutic effect of treatment. A male patient underwent reversed total shoulder replacement surgery in the beach chair position under general anesthesia. The patient experienced postoperative hoarseness, and it was revealed that he had right arytenoid dislocation. Voice restoration was accomplished with closed reduction. We discussed changes in patient position during the operation and how they may contribute to the arytenoid dislocation. Flexion and a slight rotation of the neck during the operation can lead to an increase in intracuff pressure of the endotracheal tube. It is necessary to check neck position and monitor intracuff pressure in patients undergoing operations in the beach chair position. Also, the anesthesiologist should suspect arytenoid dislocation in the case of persistent hoarseness after surgery in the beach chair position. PMID:27482316

  16. Estimation of Comfortable/Uncomfortable Feeling Based on EEG by Using NN and k-means Algorithm for Massage Chair

    NASA Astrophysics Data System (ADS)

    Teramae, Tatsuya; Kushida, Daisuke; Takemori, Fumiaki; Kitamura, Akira

    A present massage chair realizes the massage motion and force designed by a professional masseur. However, appropriate massage force to the user can not be provided by the massage chair in such a method. On the other hand, the professional masseur can realize an appropriate massage force to more than one patient, because, the masseur considers the physical condition of the patient. Our research proposed the intelligent massage system of applying masseur's procedure for the massage chair using estimated skin elasticity and DB to relate skin elasticity and massage force. However, proposed system has a problem that DB does not adjust to unknown user, because user's feeling by massage can not be estimated. Then, this paper proposed the estimation method of comfortable/uncomfortable feeling based on EEG using the neural network and k-means algorithm. The realizability of the proposed method is verified by the experimental works.

  17. Arytenoid cartilage dislocation after reversed total shoulder replacement surgery in the beach chair position: a case report.

    PubMed

    Sim, Yeo Hae; Choi, Jeong-Hyun; Kim, Mi Kyeong

    2016-08-01

    Arytenoid cartilage dislocation is not a common complication, but its delayed diagnosis reduces the therapeutic effect of treatment. A male patient underwent reversed total shoulder replacement surgery in the beach chair position under general anesthesia. The patient experienced postoperative hoarseness, and it was revealed that he had right arytenoid dislocation. Voice restoration was accomplished with closed reduction. We discussed changes in patient position during the operation and how they may contribute to the arytenoid dislocation. Flexion and a slight rotation of the neck during the operation can lead to an increase in intracuff pressure of the endotracheal tube. It is necessary to check neck position and monitor intracuff pressure in patients undergoing operations in the beach chair position. Also, the anesthesiologist should suspect arytenoid dislocation in the case of persistent hoarseness after surgery in the beach chair position. PMID:27482316

  18. 29 CFR 500.105 - DOT standards adopted by the Secretary.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the purposes of this section has adopted from 49 CFR part 398 the following pertinent standards. (In... conform the language to these regulations): (1) Qualification of drivers or operators (Source: 49 CFR 398...) Driving of motor vehicles (Source: 49 CFR 398.4)—(i) Compliance required. Every person shall comply...

  19. 29 CFR 500.105 - DOT standards adopted by the Secretary.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the purposes of this section has adopted from 49 CFR part 398 the following pertinent standards. (In... conform the language to these regulations): (1) Qualification of drivers or operators (Source: 49 CFR 398...) Driving of motor vehicles (Source: 49 CFR 398.4)—(i) Compliance required. Every person shall comply...

  20. 29 CFR 500.105 - DOT standards adopted by the Secretary.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the purposes of this section has adopted from 49 CFR part 398 the following pertinent standards. (In... conform the language to these regulations): (1) Qualification of drivers or operators (Source: 49 CFR 398...) Driving of motor vehicles (Source: 49 CFR 398.4)—(i) Compliance required. Every person shall comply...

  1. 29 CFR 500.105 - DOT standards adopted by the Secretary.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the purposes of this section has adopted from 49 CFR part 398 the following pertinent standards. (In... conform the language to these regulations): (1) Qualification of drivers or operators (Source: 49 CFR 398...) Driving of motor vehicles (Source: 49 CFR 398.4)—(i) Compliance required. Every person shall comply...

  2. 29 CFR 500.105 - DOT standards adopted by the Secretary.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the purposes of this section has adopted from 49 CFR part 398 the following pertinent standards. (In... conform the language to these regulations): (1) Qualification of drivers or operators (Source: 49 CFR 398...) Driving of motor vehicles (Source: 49 CFR 398.4)—(i) Compliance required. Every person shall comply...

  3. CONFORMANCE IMPROVEMENT USING GELS

    SciTech Connect

    Randall S. Seright

    2004-03-01

    This technical progress report describes work performed from September 1, 2003, through February 29, 2004, for the project, ''Conformance Improvement Using Gels.'' We examined the properties of several ''partially formed'' gels that were formulated with a combination of high and low molecular weight HPAM polymers. After placement in 4-mm-wide fractures, these gels required about 25 psi/ft for brine to breach the gel (the best performance to date in fractures this wide). After this breach, stabilized residual resistance factors decreased significantly with increased flow rate. Also, residual resistance factors were up to 9 times greater for water than for oil. Nevertheless, permeability reduction factors were substantial for both water and oil flow. Gel with 2.5% chopped fiberglass effectively plugged 4-mm-wide fractures if a 0.5-mm-wide constriction was present. The ability to screen-out at a constriction appears crucial for particulate incorporation to be useful in plugging fractures. In addition to fiberglass, we examined incorporation of polypropylene fibers into gels. Once dispersed in brine or gelant, the polypropylene fibers exhibited the least gravity segregation of any particulate that we have tested to date. In fractures with widths of at least 2 mm, 24-hr-old gels (0.5% high molecular weight HPAM) with 0.5% fiber did not exhibit progressive plugging during placement and showed extrusion pressure gradients similar to those of gels without the fiber. The presence of the fiber roughly doubled the gel's resistance to first breach by brine flow. The breaching pressure gradients were not as large as for gels made with high and low molecular weight polymers (mentioned above). However, their material requirements and costs (i.e., polymer and/or particulate concentrations) were substantially lower than for those gels. A partially formed gel made with 0.5% HPAM did not enter a 0.052-mm-wide fracture when applying a pressure gradient of 65 psi/ft. This result

  4. CONFORMANCE IMPROVEMENT USING GELS

    SciTech Connect

    Randall S. Seright

    2004-09-30

    This report describes work performed during the third and final year of the project, ''Conformance Improvement Using Gels.'' Corefloods revealed throughput dependencies of permeability reduction by polymers and gels that were much more prolonged during oil flow than water flow. This behavior was explained using simple mobility ratio arguments. A model was developed that quantitatively fits the results and predicts ''clean up'' times for oil productivity when production wells are returned to service after application of a polymer or gel treatment. X-ray computed microtomography studies of gels in strongly water-wet Berea sandstone and strongly oil-wet porous polyethylene suggested that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than gel-ripping or gel-displacement mechanisms. In contrast, analysis of data from the University of Kansas suggests that the gel-ripping or displacement mechanisms are more important in more permeable, strongly water-wet sandpacks. These findings help to explain why aqueous gels can reduce permeability to water more than to oil under different conditions. Since cement is the most commonly used material for water shutoff, we considered when gels are preferred over cements. Our analysis and experimental results indicated that cement cannot be expected to completely fill (top to bottom) a vertical fracture of any width, except near the wellbore. For vertical fractures with apertures less than 4 mm, the cement slurry will simply not penetrate very far into the fracture. For vertical fractures with apertures greater than 4 mm, the slurry may penetrate a substantial distance into the bottom part of the fracture. However, except near the wellbore, the upper part of the fracture will remain open due to gravity segregation. We compared various approaches to plugging fractures using gels, including (1) varying polymer content, (2) varying placement (extrusion) rate, (3) using partially formed gels, (4

  5. The Texas Adoption Project: Adopted Children and Their Intellectual Resemblance to Biological and Adoptive Parents.

    ERIC Educational Resources Information Center

    Horn, Joseph M.

    1983-01-01

    Intelligence test scores were obtained from parents and children in 300 adoptive families and compared with similar data available from the children's biological mothers. Results support the hypothesis that genetic variability is an important influence in the development of individual differences in intelligence. (Author/RH)

  6. Dynamic clustering threshold reduces conformer ensemble size while maintaining a biologically relevant ensemble.

    PubMed

    Yongye, Austin B; Bender, Andreas; Martínez-Mayorga, Karina

    2010-08-01

    Representing the 3D structures of ligands in virtual screenings via multi-conformer ensembles can be computationally intensive, especially for compounds with a large number of rotatable bonds. Thus, reducing the size of multi-conformer databases and the number of query conformers, while simultaneously reproducing the bioactive conformer with good accuracy, is of crucial interest. While clustering and RMSD filtering methods are employed in existing conformer generators, the novelty of this work is the inclusion of a clustering scheme (NMRCLUST) that does not require a user-defined cut-off value. This algorithm simultaneously optimizes the number and the average spread of the clusters. Here we describe and test four inter-dependent approaches for selecting computer-generated conformers, namely: OMEGA, NMRCLUST, RMS filtering and averaged-RMS filtering. The bioactive conformations of 65 selected ligands were extracted from the corresponding protein:ligand complexes from the Protein Data Bank, including eight ligands that adopted dissimilar bound conformations within different receptors. We show that NMRCLUST can be employed to further filter OMEGA-generated conformers while maintaining biological relevance of the ensemble. It was observed that NMRCLUST (containing on average 10 times fewer conformers per compound) performed nearly as well as OMEGA, and both outperformed RMS filtering and averaged-RMS filtering in terms of identifying the bioactive conformations with excellent and good matches (0.5 < RMSD < 1.0 A). Furthermore, we propose thresholds for OMEGA root-mean square filtering depending on the number of rotors in a compound: 0.8, 1.0 and 1.4 for structures with low (1-4), medium (5-9) and high (10-15) numbers of rotatable bonds, respectively. The protocol employed is general and can be applied to reduce the number of conformers in multi-conformer compound collections and alleviate the complexity of downstream data processing in virtual screening experiments

  7. Delineating the conformational flexibility of trisaccharides from NMR spectroscopy experiments and computer simulations.

    PubMed

    Yang, Mingjun; Angles d'Ortoli, Thibault; Säwén, Elin; Jana, Madhurima; Widmalm, Göran; MacKerell, Alexander D

    2016-07-28

    The conformation of saccharides in solution is challenging to characterize in the context of a single well-defined three-dimensional structure. Instead, they are better represented by an ensemble of conformations associated with their structural diversity and flexibility. In this study, we delineate the conformational heterogeneity of five trisaccharides via a combination of experimental and computational techniques. Experimental NMR measurements target conformationally sensitive parameters, including J couplings and effective distances around the glycosidic linkages, while the computational simulations apply the well-calibrated additive CHARMM carbohydrate force field in combination with efficient enhanced sampling molecular dynamics simulation methods. Analysis of conformational heterogeneity is performed based on sampling of discreet states as defined by dihedral angles, on root-mean-square differences of Cartesian coordinates and on the extent of volume sampled. Conformational clustering, based on the glycosidic linkage dihedral angles, shows that accounting for the full range of sampled conformations is required to reproduce the experimental data, emphasizing the utility of the molecular simulations in obtaining an atomic detailed description of the conformational properties of the saccharides. Results show the presence of differential conformational preferences as a function of primary sequence and glycosidic linkage types. Significant differences in conformational ensembles associated with the anomeric configuration of a single glycosidic linkage reinforce the impact of such changes on the conformational properties of carbohydrates. The present structural insights of the studied trisaccharides represent a foundation for understanding the range of conformations adopted in larger oligosaccharides and how these molecules encode their conformational heterogeneity into the monosaccharide sequence. PMID:27346493

  8. Protein Allostery and Conformational Dynamics.

    PubMed

    Guo, Jingjing; Zhou, Huan-Xiang

    2016-06-01

    The functions of many proteins are regulated through allostery, whereby effector binding at a distal site changes the functional activity (e.g., substrate binding affinity or catalytic efficiency) at the active site. Most allosteric studies have focused on thermodynamic properties, in particular, substrate binding affinity. Changes in substrate binding affinity by allosteric effectors have generally been thought to be mediated by conformational transitions of the proteins or, alternatively, by changes in the broadness of the free energy basin of the protein conformational state without shifting the basin minimum position. When effector binding changes the free energy landscape of a protein in conformational space, the change affects not only thermodynamic properties but also dynamic properties, including the amplitudes of motions on different time scales and rates of conformational transitions. Here we assess the roles of conformational dynamics in allosteric regulation. Two cases are highlighted where NMR spectroscopy and molecular dynamics simulation have been used as complementary approaches to identify residues possibly involved in allosteric communication. Perspectives on contentious issues, for example, the relationship between picosecond-nanosecond local and microsecond-millisecond conformational exchange dynamics, are presented. PMID:26876046

  9. Embryo adoption: Some further considerations.

    PubMed

    Patterson, Colin

    2015-02-01

    Recent discussions of embryo adoption have sought to make sense of the teaching of the Congregation for the Doctrine of the Faith (CDF) document Dignitas personae which appeared to provide a negative judgment on such a practice. This article aims to provide a personalist account of the process of fertilization and implantation that might serve as the basis for the negative judgment of the CDF document. In doing so, it relies upon the idea that a person, including an embryo, is not to be considered in isolation, but always in relation to God and to others. This approach extends the substantialist conceptualizations commonly employed in discussions of this issue. More generally, the article seeks to highlight the value of a personalist re-framing for an understanding of the moral questions surrounding the beginning of life. Lay summary: This article seeks to make sense of what appears to be a clear-cut rejection, set out in the Congregation for the Doctrine of the Faith (CDF) document Dignitas personae, of the proposal for women to "adopt" surplus frozen embryos. It draws upon more recently developed modes of philosophical/theological reasoning to argue that, in human procreation, both fertilization and implantation represent constitutive dimensions of divine creative activity and so must be protected from manipulative technological intervention. Since embryo adoption requires this kind of technology, it makes sense for the Church document not to approve it. PMID:25698841

  10. Linkage-specific conformational ensembles of non-canonical polyubiquitin chains.

    PubMed

    Castañeda, Carlos A; Chaturvedi, Apurva; Camara, Christina M; Curtis, Joseph E; Krueger, Susan; Fushman, David

    2016-02-17

    Polyubiquitination is a critical protein post-translational modification involved in a variety of processes in eukaryotic cells. The molecular basis for selective recognition of the polyubiquitin signals by cellular receptors is determined by the conformations polyubiquitin chains adopt; this has been demonstrated for K48- and K63-linked chains. Recent studies of the so-called non-canonical chains (linked via K6, K11, K27, K29, or K33) suggest they play important regulatory roles in growth, development, and immune system pathways, but biophysical studies are needed to elucidate the physical/structural basis of their interactions with receptors. A first step towards this goal is characterization of the conformations these chains adopt in solution. We assembled diubiquitins (Ub2) comprised of every lysine linkage. Using solution NMR measurements, small-angle neutron scattering (SANS), and in silico ensemble generation, we determined population-weighted conformational ensembles that shed light on the structure and dynamics of the non-canonical polyubiquitin chains. We found that polyubiquitin is conformationally heterogeneous, and each chain type exhibits unique conformational ensembles. For example, K6-Ub2 and K11-Ub2 (at physiological salt concentration) are in dynamic equilibrium between at least two conformers, where one exhibits a unique Ub/Ub interface, distinct from that observed in K48-Ub2 but similar to crystal structures of these chains. Conformers for K29-Ub2 and K33-Ub2 resemble recent crystal structures in the ligand-bound state. Remarkably, a number of diubiquitins adopt conformers similar to K48-Ub2 or K63-Ub2, suggesting potential overlap of biological function among different lysine linkages. These studies highlight the potential power of determining function from elucidation of conformational states. PMID:26422168

  11. CONFORMANCE IMPROVEMENT USING GELS

    SciTech Connect

    Randall S. Seright

    2003-09-01

    This report describes work performed during the second year of the project, ''Conformance Improvement Using Gels.'' The project has two objectives. The first objective is to identify gel compositions and conditions that substantially reduce flow through fractures that allow direct channeling between wells, while leaving secondary fractures open so that high fluid injection and production rates can be maintained. The second objective is to optimize treatments in fractured production wells, where the gel must reduce permeability to water much more than that to oil. Pore-level images from X-ray computed microtomography were re-examined for Berea sandstone and porous polyethylene. This analysis suggests that oil penetration through gel-filled pores occurs by a gel-dehydration mechanism, rather than a gel-ripping mechanism. This finding helps to explain why aqueous gels can reduce permeability to water more than to oil. We analyzed a Cr(III)-acetate-HPAM gel treatment in a production well in the Arbuckle formation. The availability of accurate pressure data before, during, and after the treatment was critical for the analysis. After the gel treatment, water productivity was fairly constant at about 20% of the pre-treatment value. However, oil productivity was stimulated by a factor of 18 immediately after the treatment. During the six months after the treatment, oil productivity gradually decreased to approach the pre-treatment value. To explain this behavior, we proposed that the fracture area open to oil flow was increased substantially by the gel treatment, followed by a gradual closing of the fractures during subsequent production. For a conventional Cr(III)-acetate-HPAM gel, the delay between gelant preparation and injection into a fracture impacts the placement, leakoff, and permeability reduction behavior. Formulations placed as partially formed gels showed relatively low pressure gradients during placement, and yet substantially reduced the flow capacity of

  12. SERCA mutant E309Q binds two Ca2+ ions but adopts a catalytically incompetent conformation

    PubMed Central

    Clausen, Johannes D; Bublitz, Maike; Arnou, Bertrand; Montigny, Cédric; Jaxel, Christine; Møller, Jesper Vuust; Nissen, Poul; Andersen, Jens Peter; le Maire, Marc

    2013-01-01

    The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) couples ATP hydrolysis to transport of Ca2+. This directed energy transfer requires cross-talk between the two Ca2+ sites and the phosphorylation site over 50 Å distance. We have addressed the mechano-structural basis for this intramolecular signal by analysing the structure and the functional properties of SERCA mutant E309Q. Glu309 contributes to Ca2+ coordination at site II, and a consensus has been that E309Q only binds Ca2+ at site I. The crystal structure of E309Q in the presence of Ca2+ and an ATP analogue, however, reveals two occupied Ca2+ sites of a non-catalytic Ca2E1 state. Ca2+ is bound with micromolar affinity by both Ca2+ sites in E309Q, but without cooperativity. The Ca2+-bound mutant does phosphorylate from ATP, but at a very low maximal rate. Phosphorylation depends on the correct positioning of the A-domain, requiring a shift of transmembrane segment M1 into an ‘up and kinked position'. This transition is impaired in the E309Q mutant, most likely due to a lack of charge neutralization and altered hydrogen binding capacities at Ca2+ site II. PMID:24270570

  13. p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein-Protein Interactions.

    PubMed

    Bulfer, Stacie L; Chou, Tsui-Fen; Arkin, Michelle R

    2016-08-19

    The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein-protein interaction (PPI) domain into "up" and "down" conformations. Point mutations that cause multisystem proteinopathy 1 (MSP1) are found at the interface of the N domain and D1-ATPase domain and potentially alter the conformational preferences of p97. Additionally, binding of "adaptor" proteins to the N-domain regulates p97's catalytic activity. We propose that p97/adaptor PPIs are coupled to p97 conformational states. We evaluated the binding of nucleotides and the adaptor proteins p37 and p47 to wild-type p97 and MSP1 mutants. Notably, p47 and p37 bind 8-fold more weakly to the ADP-bound conformation of wild-type p97 compared to the ATP-bound conformation. However, MSP1 mutants lose this nucleotide-induced conformational coupling because they destabilize the ADP-bound, "down" conformation of the N-domain. Loss in conformation coupling to PPIs could contribute to the mechanism of MSP1. PMID:27267671

  14. To Conform or Not to Conform: Spontaneous Conformity Diminishes the Sensitivity to Monetary Outcomes

    PubMed Central

    2013-01-01

    When people have different opinions in a group, they often adjust their own attitudes and behaviors to match the group opinion, known as social conformity. The affiliation account of normative conformity states that people conform to norms in order to ‘fit in’, whereas the accuracy account of informative conformity posits that the motive to learn from others produces herding. Here, we test another possibility that following the crowd reduces the experienced negative emotion when the group decision turns out to be a bad one. Using event related potential (ERP) combined with a novel group gambling task, we found that participants were more likely to choose the option that was predominately chosen by other players in previous trials, although there was little explicit normative pressure at the decision stage and group choices were not informative. When individuals' choices were different from others, the feedback related negativity (FRN), an ERP component sensitive to losses and errors, was enhanced, suggesting that being independent is aversive. At the outcome stage, the losses minus wins FRN effect was significantly reduced following conformity choices than following independent choices. Analyses of the P300 revealed similar patterns both in the response and outcome period. Our study suggests that social conformity serves as an emotional buffer that protects individuals from experiencing strong negative emotion when the outcomes are bad. PMID:23691242

  15. Implementing a Paid Leave Policy for Graduate Students at UW-Madison: The Department Chair Perspective

    NASA Astrophysics Data System (ADS)

    Mathieu, Robert D.

    2013-01-01

    In 2010 the University of Wisconsin - Madison Astronomy Department developed and implemented a departmental paid leave policy for our graduate students, even though the university lacks a campus-wide policy and cannot provide institutional funding for such programs. This policy includes 12 weeks of paid leave in event of a medical emergency or chronic medical condition, as well as paid parental leave for both male and female graduate research assistants. Building on the graduate student perspective of Gosnell (2012), I will discuss the process of this successful development of a departmental family and medical leave policy for graduate students from the perspective of a faculty member and chair. In particular I will discuss implications of university policies, the importance of faculty and staff support, the role of private funds, and issues of effort certification.

  16. Do institutional logics predict interpretation of contract rules at the dental chair-side?

    PubMed

    Harris, Rebecca; Brown, Stephen; Holt, Robin; Perkins, Elizabeth

    2014-12-01

    In quasi-markets, contracts find purchasers influencing health care providers, although problems exist where providers use personal bias and heuristics to respond to written agreements, tending towards the moral hazard of opportunism. Previous research on quasi-market contracts typically understands opportunism as fully rational, individual responses selecting maximally efficient outcomes from a set of possibilities. We take a more emotive and collective view of contracting, exploring the influence of institutional logics in relation to the opportunistic behaviour of dentists. Following earlier qualitative work where we identified four institutional logics in English general dental practice, and six dental contract areas where there was scope for opportunism; in 2013 we surveyed 924 dentists to investigate these logics and whether they had predictive purchase over dentists' chair-side behaviour. Factor analysis involving 300 responses identified four logics entwined in (often technical) behaviour: entrepreneurial commercialism, duty to staff and patients, managerialism, public good. PMID:25441320

  17. News from the ``Dentist's Chair'': Observations of AM1353-272 with the VIMOS IFU

    NASA Astrophysics Data System (ADS)

    Weilbacher, P. M.; Duc, P.-A.

    The galaxy pair AM 1353-272 nicknamed "The Dentist's Chair" shows two ˜30 kpc long tidal tails. Previous observations using multi-slit masks showed that they host up to seven tidal dwarf galaxies. The kinematics of these tidal dwarfs appeared to be decoupled from the surrounding tidal material. New observations of the tip of the southern tidal tail with the VIMOS integral field unit confirm the results for two of these genuine tidal dwarfs but raise doubts whether the velocity gradient attributed to the outermost tidal dwarf candidate is real. We also discuss possible effects to explain the observational difference concerning the strongest velocity gradient seen in the slit data, which is undetected in the new integral field data, but arrive at no firm conclusion. Additionally, low-resolution data covering most of the two interacting partners show that the strongest line emitting regions of this system are the central parts.

  18. [The creation of chairs in tropical medicine in Peru and Brazil].

    PubMed

    Almeida, Marta de

    2011-06-01

    At the 5th Latin American Congress of Medicine, held in Lima, Peru, in 1913, the idea was put forth to establish chairs in Tropical Medicine at medical schools in Latin America. Through reference to the involvement of Julián Arce and Carlos Chagas, physicians devoted to the study of tropical medicine, the article analyzes this proposal and examines the process by which the teaching of the specialty became institutionalized in Peru and Brazil. The focus is specifically on the inaugural classes given by both professors, the former speaking before the University of San Marcos Faculty of Medicine in 1916 in Lima and the latter, before the Rio de Janeiro Faculty of Medicine in 1926. The present study hopes to contribute to a deeper understanding of the distinct meanings assigned to tropical medicine in Brazil and Peru. PMID:21779691

  19. Do institutional logics predict interpretation of contract rules at the dental chair-side?

    PubMed Central

    Harris, Rebecca; Brown, Stephen; Holt, Robin; Perkins, Elizabeth

    2014-01-01

    In quasi-markets, contracts find purchasers influencing health care providers, although problems exist where providers use personal bias and heuristics to respond to written agreements, tending towards the moral hazard of opportunism. Previous research on quasi-market contracts typically understands opportunism as fully rational, individual responses selecting maximally efficient outcomes from a set of possibilities. We take a more emotive and collective view of contracting, exploring the influence of institutional logics in relation to the opportunistic behaviour of dentists. Following earlier qualitative work where we identified four institutional logics in English general dental practice, and six dental contract areas where there was scope for opportunism; in 2013 we surveyed 924 dentists to investigate these logics and whether they had predictive purchase over dentists' chair-side behaviour. Factor analysis involving 300 responses identified four logics entwined in (often technical) behaviour: entrepreneurial commercialism, duty to staff and patients, managerialism, public good. PMID:25441320

  20. Synthesis, structural and conformational study of some esters derived from 3-methyl-3-azabicyclo[3.2.1]octan-8(α and β)-ols

    NASA Astrophysics Data System (ADS)

    Iriepa, I.; Bellanato, J.

    2014-09-01

    A series of α and β-esters bearing a 3-methyl-3-azabicyclo[3.2.1]octane moiety as well as methyl and aryl substituents were synthesized and studied by 1H and 13C NMR spectroscopies. In CDCl3 solution, at room temperature, a chair-envelope conformation for the bicycle moiety with the N-CH3 group in equatorial position with respect to the chair ring is proposed for both, α and β-esters. The chair conformation of the piperidine ring is puckered at C8 in the α-epimers and it is flattened at N3, in the β-epimers. Free rotation of the acyloxy group around the C8sbnd O bond has also been deduced. Analgesic activity of four of these substances was studied. 8β-Benzoyloxy-3-methyl-3-azabicyclo[3.2.1]octane demonstrated significant analgesic activity in the hot plate test compared to morphine. By measuring the rectal temperature in mice, results also showed a significant antipyretic activity of this compound.