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Sample records for adoptive transfer system

  1. Systemic Combination Virotherapy for Melanoma with Tumor Antigen-Expressing Vesicular Stomatitis Virus and Adoptive T-cell Transfer

    PubMed Central

    Rommelfanger, Diana M.; Wongthida, Phonphimon; Diaz, Rosa M.; Kaluza, Karen M.; Thompson, Jill M.; Kottke, Timothy J.; Vile, Richard G.

    2013-01-01

    Oncolytic virotherapy offers the potential to treat tumors both as a single agent and in combination with traditional modalities such as chemotherapy and radiotherapy. Here we describe an effective, fully systemic treatment regimen, which combines virotherapy, acting essentially as an adjuvant immunotherapy, with adoptive cell transfer (ACT). The combination of ACT with systemic administration of a vesicular stomatitis virus (VSV) engineered to express the endogenous melanocyte antigen glycoprotein 100 (gp100) resulted in regression of established melanomas and generation of antitumor immunity. Tumor response was associated with in vivo T-cell persistence and activation as well as treatment-related vitiligo. However, in a proportion of treated mice, initial tumor regressions were followed by recurrences. Therapy was further enhanced by targeting an additional tumor antigen with the VSV-antigen + ACT combination strategy, leading to sustained response in 100% of mice. Together, our findings suggest that systemic virotherapy combined with antigen-expressing VSV could be used to support and enhance clinical immunotherapy protocols with adoptive T-cell transfer, which are already used in the clinic. PMID:22836753

  2. Policy Borrowing and Transfer, and Policy Convergence: Justifications for the Adoption of the Bologna Process in the CEMAC Region and the Cameroonian Higher Education System through the LMD Reform

    ERIC Educational Resources Information Center

    Eta, Elizabeth Agbor

    2015-01-01

    The borrowing and transfer of policies, ideas and practices from one system to another may in part explain the convergence of educational systems. Using text documents as research material, this paper examines the adoption and transfer of Bologna Process (BP) ideas in the Economic and Monetary Community of Central Africa (CEMAC) and in the…

  3. An adopted analysand's transference of a 'hole-object'.

    PubMed

    Quinodoz, D

    1996-04-01

    The author describes the vicissitudes of the transference and countertransference in cases where the internal object transferred by the patient on to the analyst is experienced by the former as non-existent. A case history involving a 'hole-object' of this kind is presented, the patient concerned having been adopted at the age of six months and having the fantasy that she did not exist before her adoption. The hole-object is created by the patient to defend against psychic suffering and aggressive drives towards the object. A careful distinction is made between the hole-object, which is defined in terms of its non-existence, and the absent object, the 'psychic hole', the melancholic object and the bad-breast feeling, all of which exist or have existed at some time. The author describes the 'double transference', in which she represented both the idealised albeit well cathected adoptive parents and the disavowed, abandoning biological parents; in the latter case indifference took the place of love and hate in the transference. The analyst in this situation must in the author's view interpret his transference role as a hole-object so as to confer existence on this object and make it representable, and for this purpose a vital role falls to the countertransference. The split between the abandoning and the adopting aspects of the parents can then be resolved, giving rise to a single identificatory parental image. PMID:8771381

  4. Information Transfer and the Adoption of Agricultural Innovations.

    ERIC Educational Resources Information Center

    Longo, Rose Mary Juliano

    1990-01-01

    Data collected in the Federal District of Brazil were analyzed in terms of information transfer through mass media and interpersonal communication and how they influence farmers in the Federal District of Brazil in their decisions to adopt agricultural innovations. (42 references) (EAM)

  5. Adoptive transfer of murine relapsing experimental allergic encephalomyelitis.

    PubMed

    Lublin, F D

    1985-02-01

    Relapsing experimental allergic encephalomyelitis (EAE), an autoimmune disorder resembling multiple sclerosis, has been produced by inoculating SJL/J mice with spinal cord or myelin basic protein in appropriate adjuvants. To determine whether initially sensitized lymphocytes or the persistence of antigen depots in the animal were responsible for the relapsing episodes of inflammatory demyelination, adoptive transfer studies were undertaken utilizing lymphocytes from relapsing EAE-immunized donors transferred directly or after in vitro culture. In direct-transfer studies donor lymphocytes produced clinical and pathological signs of relapsing EAE in 3 of 7 recipients of lymph node lymphocytes and 1 of 5 recipients of splenic lymphocytes. In vitro culture of lymphocytes in myelin basic protein or T cell growth factor prior to transfer increased both the incidence of disease and the number of animals having relapses, and allowed transfer with fewer lymphocytes. Because all animals had delayed onset of disease, this study demonstrates that the ability to develop relapsing inflammatory demyelination is transferable with lymphocytes and does not require the presence of antigen. PMID:3977301

  6. Electronic Dental Records System Adoption.

    PubMed

    Abramovicz-Finkelsztain, Renata; Barsottini, Claudia G N; Marin, Heimar Fatima

    2015-01-01

    The use of Electronic Dental Records (EDRs) and management software has become more frequent, following the increase in prevelance of new technologies and computers in dental offices. The purpose of this study is to identify and evaluate the use of EDRs by the dental community in the São Paulo city area. A quantitative case study was performed using a survey on the phone. A total of 54 offices were contacted and only one declinedparticipation in this study. Only one office did not have a computer. EDRs were used in 28 offices and only four were paperless. The lack of studies in this area suggests the need for more usability and implementation studies on EDRs so that we can improve EDR adoption by the dental community. PMID:26262001

  7. Adoptive Transfer of Dying Cells Causes Bystander-Induced Apoptosis

    PubMed Central

    Schwulst, Steven J.; Davis, Christopher G.; Coopersmith, Craig M.; Hotchkiss, Richard S.

    2009-01-01

    The anti-apoptotic Bcl-2 protein has the remarkable ability to prevent cell death from several noxious stimuli. Intriguingly, Bcl-2 overexpression in one cell type has been reported to protect against cell death in neighboring non-Bcl-2 overexpressing cell types. The mechanism of this “trans” protection has been speculated to be secondary to the release of a cytoprotective factor by Bcl-2 overexpressing cells. We employed a series of adoptive transfer experiments in which lymphocytes that overexpress Bcl-2 were administered to either wild type mice or mice lacking mature T and B cells (Rag-1-/-) to detect the presence or absence of the putative protective factor. We were unable to demonstrate “trans” protection. However, adoptive transfer of apoptotic or necrotic cells exacerbated the degree of apoptotic death in neighboring non-Bcl-2 overexpressing cells (p≤0.05). Therefore, this data suggests that dying cells emit signals triggering cell death in neighboring non-Bcl-2 overexpressing cells, i.e. a “trans” destructive effect. PMID:17194455

  8. Adoptive transfer of dying cells causes bystander-induced apoptosis.

    PubMed

    Schwulst, Steven J; Davis, Christopher G; Coopersmith, Craig M; Hotchkiss, Richard S

    2007-02-16

    The anti-apoptotic Bcl-2 protein has the remarkable ability to prevent cell death from several noxious stimuli. Intriguingly, Bcl-2 overexpression in one cell type has been reported to protect against cell death in neighboring non-Bcl-2 overexpressing cell types. The mechanism of this "trans" protection has been speculated to be secondary to the release of a cytoprotective factor by Bcl-2 overexpressing cells. We employed a series of adoptive transfer experiments in which lymphocytes that overexpress Bcl-2 were administered to either wild type mice or mice lacking mature T and B cells (Rag-1-/-) to detect the presence or absence of the putative protective factor. We were unable to demonstrate "trans" protection. However, adoptive transfer of apoptotic or necrotic cells exacerbated the degree of apoptotic death in neighboring non-Bcl-2 overexpressing cells (p < or= 0.05). Therefore, this data suggests that dying cells emit signals triggering cell death in neighboring non-Bcl-2 overexpressing cells, i.e., a "trans" destructive effect. PMID:17194455

  9. Transfer system

    DOEpatents

    Kurosawa, Kanji; Koga, Bunichiro; Ito, Hideki; Kiriyama, Shigeru; Higuchi, Shizuo

    2003-05-20

    A transport system includes a traveling rail (1) which constitutes a transport route and a transport body (3) which is capable of traveling on the traveling rail in the longitudinal direction of the traveling rail. Flexible drive tubes (5) are arranged on the traveling rail in the longitudinal direction of the traveling rail. The transport body includes a traveling wheel (4) which is capable of rolling on the traveling rail and drive wheels (2) which are capable of rolling on the drive tubes upon receiving the rotational drive power generated by pressure of a pressure medium supplied to the drive tubes while depressing the drive tubes. The traveling rail includes a plurality of transport sections and the transport body is capable of receiving a rotational drive force from the drive tubes at every transport sections. If necessary, a transport route changeover switch which changes over the transport route can be provided between the transport sections.

  10. Adoption

    MedlinePlus

    ... the birth nor adoptive parents know the others' identities. Other adoptions are handled more openly. Open adoptions, ... desire to seek out more information about the identity of the birth family. Most of us (whether ...

  11. [Adoption].

    ERIC Educational Resources Information Center

    Pawl, Jeree, Ed.; And Others

    1990-01-01

    This newsletter theme issue addresses adoption and the young child's life. Contributors suggest ways in which practitioners in many professions and settings can better understand and support adoptive families. The first article, "Adoption, 1990" by Barbara F. Nordhaus and Albert J. Solnit, reviews the history of adoption and notes obstacles to…

  12. Trial Watch: Adoptive cell transfer for oncological indications

    PubMed Central

    Aranda, Fernando; Buqué, Aitziber; Bloy, Norma; Castoldi, Francesca; Eggermont, Alexander; Cremer, Isabelle; Fridman, Wolf Hervé; Fucikova, Jitka; Galon, Jérôme; Spisek, Radek; Tartour, Eric; Zitvogel, Laurence; Kroemer, Guido; Galluzzi, Lorenzo

    2015-01-01

    One particular paradigm of anticancer immunotherapy relies on the administration of (potentially) tumor-reactive immune effector cells. Generally, these cells are obtained from autologous peripheral blood lymphocytes (PBLs) ex vivo (in the context of appropriate expansion, activation and targeting protocols), and re-infused into lymphodepleted patients along with immunostimulatory agents. In spite of the consistent progress achieved throughout the past two decades in this field, no adoptive cell transfer (ACT)-based immunotherapeutic regimen is currently approved by regulatory agencies for use in cancer patients. Nonetheless, the interest of oncologists in ACT-based immunotherapy continues to increase. Accumulating clinical evidence indicates indeed that specific paradigms of ACT, such as the infusion of chimeric antigen receptor (CAR)-expressing autologous T cells, are associated with elevated rates of durable responses in patients affected by various neoplasms. In line with this notion, clinical trials investigating the safety and therapeutic activity of ACT in cancer patients are being initiated at an ever increasing pace. Here, we review recent preclinical and clinical advances in the development of ACT-based immunotherapy for oncological indications. PMID:26451319

  13. CTLA-4 blockade plus adoptive T cell transfer promotes optimal melanoma immunity in mice

    PubMed Central

    Mahvi, David A.; Meyers, Justin V.; Tatar, Andrew J.; Contreras, Amanda; Suresh, M.; Leverson, Glen E.; Sen, Siddhartha; Cho, Clifford S.

    2014-01-01

    Immunotherapeutic approaches to the treatment of advanced melanoma have relied on strategies that augment the responsiveness of endogenous tumor-specific T cell populations (e.g., CTLA-4 blockade-mediated checkpoint inhibition) or introduce exogenously-prepared tumor-specific T cell populations (e.g., adoptive cell transfer). Although both approaches have shown considerable promise, response rates to these therapies remain suboptimal. We hypothesized that a combinatorial approach to immunotherapy using both CTLA-4 blockade and non-lymphodepletional adoptive cell transfer could offer additive therapeutic benefit. C57BL/6 mice were inoculated with syngeneic B16F10 melanoma tumors transfected to express low levels of the lymphocytic choriomeningitis virus peptide GP33 (B16GP33), and treated with no immunotherapy, CTLA-4 blockade, adoptive cell transfer, or combination immunotherapy of CTLA-4 blockade with adoptive cell transfer. Combination immunotherapy resulted in optimal control of B16GP33 melanoma tumors. Combination immunotherapy promoted a stronger local immune response reflected by enhanced tumor-infiltrating lymphocyte populations, as well as a stronger systemic immune responses reflected by more potent tumor antigen-specific T cell activity in splenocytes. In addition, whereas both CTLA-4 blockade and combination immunotherapy were able to promote long-term immunity against B16GP33 tumors, only combination immunotherapy was capable of promoting immunity against parental B16F10 tumors as well. Our findings suggest that a combinatorial approach using CTLA-4 blockade with non-lymphodepletional adoptive cell transfer may promote additive endogenous and exogenous T cell activities that enable greater therapeutic efficacy in the treatment of melanoma. PMID:25658614

  14. An Investigation of the Adoption Process in Training Technology Transfer.

    ERIC Educational Resources Information Center

    Freda, Jon S.; Shields, Joyce L.

    A study investigated the influence of users' attitudes and sources of information on their adoption of a training research project. A two-part questionnaire was administered to 111 Army participants attending TRADOC/FORSCOM Training and Evaluation Workshops to gather attitudinal and usage information relating to the adoption of the Training…

  15. Heat transfer system

    DOEpatents

    McGuire, Joseph C.

    1982-01-01

    A heat transfer system for a nuclear reactor. Heat transfer is accomplished within a sealed vapor chamber which is substantially evacuated prior to use. A heat transfer medium, which is liquid at the design operating temperatures, transfers heat from tubes interposed in the reactor primary loop to spaced tubes connected to a steam line for power generation purposes. Heat transfer is accomplished by a two-phase liquid-vapor-liquid process as used in heat pipes. Condensible gases are removed from the vapor chamber through a vertical extension in open communication with the chamber interior.

  16. Heat transfer system

    DOEpatents

    Not Available

    1980-03-07

    A heat transfer system for a nuclear reactor is described. Heat transfer is accomplished within a sealed vapor chamber which is substantially evacuated prior to use. A heat transfer medium, which is liquid at the design operating temperatures, transfers heat from tubes interposed in the reactor primary loop to spaced tubes connected to a steam line for power generation purposes. Heat transfer is accomplished by a two-phase liquid-vapor-liquid process as used in heat pipes. Condensible gases are removed from the vapor chamber through a vertical extension in open communication with the chamber interior.

  17. Dissecting memory T cell responses to TB: concerns using adoptive transfer into immunodeficient mice.

    PubMed

    Ancelet, Lindsay; Rich, Fenella J; Delahunt, Brett; Kirman, Joanna R

    2012-09-01

    Several studies have used adoptive transfer of purified T cell subsets into immunodeficient mice to determine the subset of T cells responsible for mediating protection against Mycobacterium tuberculosis. These studies suggested that CD62L(hi) memory CD4(+) T cells from BCG-vaccinated mice are key for protection against tuberculosis. Importantly, we observed that transfer of naïve CD4(+) T cells into Rag1-/- recipients protected against a mycobacterial challenge as well as transfer of BCG-experienced CD4(+) T cells. We found that transfer of total CD4(+) T cells from naïve mice or enriched CD62L(hi)CD4(+) T cells from BCG-vaccinated mice into Rag1-/- recipients induced severe colitis by 3 weeks post cell transfer, whereas transfer of CD62L(lo)CD4(+) T cells from BCG-vaccinated mice did not. Naïve and CD62L(hi)CD4(+) T cells proliferated extensively upon transfer and developed an activated effector phenotype in the lung, even in the absence of infectious challenge. The induction of colitis and systemic cytokine response induced by the transfer and subsequent activation of CD4(+) T cells from naïve mice or CD62L(hi)CD4(+) T cells from BCG-vaccinated mice, into immunodeficient recipients, may heighten their ability to protect against mycobacterial challenge. This raises doubts about the validity of this model to study CD4(+) T cell-mediated protection against tuberculosis. PMID:22738879

  18. Elimination of Metastatic Melanoma Using Gold Nanoshell-Enabled Photothermal Therapy and Adoptive T Cell Transfer

    PubMed Central

    Perna, Serena K.; Mattos Almeida, Joao Paulo; Lin, Adam Y.; Eckels, Phillip C.; Drezek, Rebekah A.; Foster, Aaron E.

    2013-01-01

    Ablative treatments such as photothermal therapy (PTT) are attractive anticancer strategies because they debulk accessible tumor sites while simultaneously priming antitumor immune responses. However, the immune response following thermal ablation is often insufficient to treat metastatic disease. Here we demonstrate that PTT induces the expression of proinflammatory cytokines and chemokines and promotes the maturation of dendritic cells within tumor-draining lymph nodes, thereby priming antitumor T cell responses. Unexpectedly, however, these immunomodulatory effects were not beneficial to overall antitumor immunity. We found that PTT promoted the infiltration of secondary tumor sites by CD11b+Ly-6G/C+ myeloid-derived suppressor cells, consequently failing to slow the growth of poorly immunogenic B16-F10 tumors and enhancing the growth of distant lung metastases. To exploit the beneficial effects of PTT activity against local tumors and on antitumor immunity whilst avoiding the adverse consequences, we adoptively transferred gp100-specific pmel T cells following PTT. The combination of local control by PTT and systemic antitumor immune reactivity provided by adoptively transferred T cells prevented primary tumor recurrence post-ablation, inhibited tumor growth at distant sites, and abrogated the outgrowth of lung metastases. Hence, the combination of PTT and systemic immunotherapy prevented the adverse effects of PTT on metastatic tumor growth and optimized overall tumor control. PMID:23935927

  19. Fuel transfer system

    DOEpatents

    Townsend, Harold E.; Barbanti, Giancarlo

    1994-01-01

    A nuclear fuel bundle fuel transfer system includes a transfer pool containing water at a level above a reactor core. A fuel transfer machine therein includes a carriage disposed in the transfer pool and under the water for transporting fuel bundles. The carriage is selectively movable through the water in the transfer pool and individual fuel bundles are carried vertically in the carriage. In a preferred embodiment, a first movable bridge is disposed over an upper pool containing the reactor core, and a second movable bridge is disposed over a fuel storage pool, with the transfer pool being disposed therebetween. A fuel bundle may be moved by the first bridge from the reactor core and loaded into the carriage which transports the fuel bundle to the second bridge which picks up the fuel bundle and carries it to the fuel storage pool.

  20. Fuel transfer system

    DOEpatents

    Townsend, H.E.; Barbanti, G.

    1994-03-01

    A nuclear fuel bundle fuel transfer system includes a transfer pool containing water at a level above a reactor core. A fuel transfer machine therein includes a carriage disposed in the transfer pool and under the water for transporting fuel bundles. The carriage is selectively movable through the water in the transfer pool and individual fuel bundles are carried vertically in the carriage. In a preferred embodiment, a first movable bridge is disposed over an upper pool containing the reactor core, and a second movable bridge is disposed over a fuel storage pool, with the transfer pool being disposed therebetween. A fuel bundle may be moved by the first bridge from the reactor core and loaded into the carriage which transports the fuel bundle to the second bridge which picks up the fuel bundle and carries it to the fuel storage pool. 6 figures.

  1. A New Hope in Immunotherapy for Malignant Gliomas: Adoptive T Cell Transfer Therapy

    PubMed Central

    Chung, Dong-Sup; Shin, Hye-Jin; Hong, Yong-Kil

    2014-01-01

    Immunotherapy emerged as a promising therapeutic approach to highly incurable malignant gliomas due to tumor-specific cytotoxicity, minimal side effect, and a durable antitumor effect by memory T cells. But, antitumor activities of endogenously activated T cells induced by immunotherapy such as vaccination are not sufficient to control tumors because tumor-specific antigens may be self-antigens and tumors have immune evasion mechanisms to avoid immune surveillance system of host. Although recent clinical results from vaccine strategy for malignant gliomas are encouraging, these trials have some limitations, particularly their failure to expand tumor antigen-specific T cells reproducibly and effectively. An alternative strategy to overcome these limitations is adoptive T cell transfer therapy, in which tumor-specific T cells are expanded ex vivo rapidly and then transferred to patients. Moreover, enhanced biologic functions of T cells generated by genetic engineering and modified immunosuppressive microenvironment of host by homeostatic T cell expansion and/or elimination of immunosuppressive cells and molecules can induce more potent antitumor T cell responses and make this strategy hold promise in promoting a patient response for malignant glioma treatment. Here we will review the past and current progresses and discuss a new hope in adoptive T cell therapy for malignant gliomas. PMID:25009822

  2. Determinants of Effective Information Transfer in International Regulatory Standards Adoption

    ERIC Educational Resources Information Center

    Popescu, Denisa

    2010-01-01

    The role of international regulatory standards within the current global environment has become of the most importance. The age of the global system and free market capitalism carried us into the unprecedented age of regulations, and standard setting. Regulations are now becoming the emerging mode of global governance. This study focuses on…

  3. Restoration of Viral Immunity in Immunodeficient Humans by the Adoptive Transfer of T Cell Clones

    NASA Astrophysics Data System (ADS)

    Riddell, Stanley R.; Watanabe, Kathe S.; Goodrich, James M.; Li, Cheng R.; Agha, Mounzer E.; Greenberg, Philip D.

    1992-07-01

    The adoptive transfer of antigen-specific T cells to establish immunity is an effective therapy for viral infections and tumors in animal models. The application of this approach to human disease would require the isolation and in vitro expansion of human antigen-specific T cells and evidence that such T cells persist and function in vivo after transfer. Cytomegalovirus-specific CD8^+ cytotoxic T cell (CTL) clones could be isolated from bone marrow donors, propagated in vitro, and adoptively transferred to immunodeficient bone marrow transplant recipients. No toxicity developed and the clones provided persistent reconstitution of CD8^+ cytomegalovirus-specific CTL responses.

  4. Negotiating the Dance: Consulting with Adoptive Systems.

    ERIC Educational Resources Information Center

    Becker, Kent W.; Carson, David K.; Seto, Atsuko; Becker, Carol A.

    2002-01-01

    For marriage and family therapists and educators who train future marriage and family therapists, families formed by means of adoption offer an abundance of learning opportunities in both the areas of assessment and intervention. The following consultation case represents a composite family designed to highlight the unique features of adoptive…

  5. Orbital Fluid Transfer System

    NASA Technical Reports Server (NTRS)

    Johnston, A. S., (Nick); Ryder, Mel; Tyler, Tony R.

    1998-01-01

    An automated fluid and power interface system needs to be developed for future space missions which require on orbit consumable replenishment. Current method of fluid transfer require manned vehicles and extravehicular activity. Currently the US does not have an automated capability for consumable transfer on-orbit. This technology would benefit both Space Station and long duration satellites. In order to provide this technology the Automated Fluid Interface System (AFIS) was developed. The AFIS project was an advanced development program aimed at developing a prototype satellite servicer for future space operations. This mechanism could transfer propellants, cryogens, fluids, gasses, electrical power, and communications from a tanker unit to the orbiting satellite. The development of this unit was a cooperative effort between Marshall Space Flight Center in Huntsville, Alabama, and Moog, Inc. in East Aurora, New York. An engineering model was built and underwent substantial development testing at Marshall Space Flight Center (MSFC). While the AFIS is not suitable for spaceflight, testing and evaluation of the AFIS provided significant experience which would be beneficial in building a flight unit. The lessons learned from testing the AFIS provided the foundation for the next generation fluid transfer mechanism, the Orbital Fluid Transfer System (OFTS). The OFTS project was a study contract with MSFC and Moog, Inc. The OFTS was designed for the International Space Station (ISS), but its flexible design could used for long duration satellite missions and other applications. The OFTS was designed to be used after docking. The primary function was to transfer bipropellants and high pressure gases. The other items addressed by this task included propellant storage, hardware integration, safety and control system issues. A new concept for high pressure couplings was also developed. The results of the AFIS testing provided an excellent basis for the OFTS design. The OFTS

  6. Health information systems adoption: findings from a systematic review.

    PubMed

    Yusof, Maryati Mohd; Stergioulas, Lampros; Zugic, Jasmina

    2007-01-01

    Earlier evaluation studies on Health Information Systems (HIS) adoption have highlighted a large number of adoption problems that were attributed to the lack of fit between technology, human and organisation factors. Lessons can be learned from these evaluation studies by identifying the most important factors of HIS adoption. In order to study the adoption issue, a qualitative systematic review has been performed using a recently introduced framework, known as HOT-fit (Human, Organisation and Technology fit). The paper identifies and highlights the following critical adoption factors: technology (ease of use, system usefulness, system flexibility, time efficiency, information accessibility and relevancy); human (user training, user perception, user roles, user skills, clarity of system purpose, user involvement); organisation (leadership and support, clinical process, user involvement, internal communication, inter organisational system, as well as the fit between them. The findings can be used to guide future system development and inform relevant decision making. PMID:17911719

  7. Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation.

    PubMed

    Xu, Wei; Lan, Qin; Chen, Maogen; Chen, Hui; Zhu, Ning; Zhou, Xiaohui; Wang, Julie; Fan, Huimin; Yan, Chun-Song; Kuang, Jiu-Long; Warburton, David; Togbe, Dieudonnée; Ryffel, Bernhard; Zheng, Song-Guo; Shi, Wei

    2012-01-01

    Both nature and induced regulatory T (Treg) lymphocytes are potent regulators of autoimmune and allergic disorders. Defects in endogenous Treg cells have been reported in patients with allergic asthma, suggesting that disrupted Treg cell-mediated immunological regulation may play an important role in airway allergic inflammation. In order to determine whether adoptive transfer of induced Treg cells generated in vitro can be used as an effective therapeutic approach to suppress airway allergic inflammation, exogenously induced Treg cells were infused into ovalbumin-sensitized mice prior to or during intranasal ovalbumin challenge. The results showed that adoptive transfer of induced Treg cells prior to allergen challenge markedly reduced airway hyperresponsiveness, eosinophil recruitment, mucus hyper-production, airway remodeling, and IgE levels. This effect was associated with increase of Treg cells (CD4(+)FoxP3(+)) and decrease of dendritic cells in the draining lymph nodes, and with reduction of Th1, Th2, and Th17 cell response as compared to the controls. Moreover, adoptive transfer of induced Treg cells during allergen challenge also effectively attenuate airway inflammation and improve airway function, which are comparable to those by natural Treg cell infusion. Therefore, adoptive transfer of in vitro induced Treg cells may be a promising therapeutic approach to prevent and treat severe asthma. PMID:22792275

  8. Wireless power transfer system

    DOEpatents

    Wu, Hunter; Sealy, Kylee; Gilchrist, Aaron

    2016-02-23

    A system includes a first stage of an inductive power transfer system with an LCL load resonant converter with a switching section, an LCL tuning circuit, and a primary receiver pad. The IPT system includes a second stage with a secondary receiver pad, a secondary resonant circuit, a secondary rectification circuit, and a secondary decoupling converter. The secondary receiver pad connects to the secondary resonant circuit. The secondary resonant circuit connects to the secondary rectification circuit. The secondary rectification circuit connects to the secondary decoupling converter. The second stage connects to a load. The load includes an energy storage element. The second stage and load are located on a vehicle and the first stage is located at a fixed location. The primary receiver pad wirelessly transfers power to the secondary receiver pad across a gap when the vehicle positions the secondary receiver pad with respect to the primary receiver pad.

  9. Factors Affecting the Adoption of an E-Assessment System

    ERIC Educational Resources Information Center

    McCann, Ann L.

    2010-01-01

    A case study was conducted in 2006-07 to explore how one US campus implemented a centralised e-assessment system. The study specifically measured the extent of adoption by faculty members, identified their reasons for adoption and evaluated the impact on teaching and learning. The purposes of the system, entitled researching learning (REAL, a…

  10. CURRENT TRANSFER SYSTEMS

    DOEpatents

    Watt, D.A.

    1956-07-01

    A current transfer system is described for transferring current between a rotating member and a co-axial stationary member. The particular area of application for the invention is in connection with homopolar generators where a low voltage and high current are generated. The current tramsfer system of the invention comprises a rotor member and a co-axial stator member wherein one of the members is shaped to provide a circumferential surface concave in section and the other member is shaped to have a peripheral portion in close proximity to the surface, whereby a liquid metal can be stably supported between the two members when they are moving relative to one another to establish an electrical conducting path between the members.

  11. Thermal flux transfer system

    NASA Technical Reports Server (NTRS)

    Freggens, R. A. (Inventor)

    1973-01-01

    A thermal flux transfer system for use in maintaining the thrust chamber of an operative reaction motor at given temperatures is described. The system is characterized by an hermetically sealed chamber surrounding a thrust chamber to be cooled, with a plurality of parallel, longitudinally spaced, disk-shaped wick members formed of a metallic mesh and employed in delivering a working fluid, in its liquid state, radially toward the thrust chamber and delivering the working fluid, in its vapor state, away from the nozzle for effecting a cooling of the nozzle, in accordance with known principles of an operating heat pipe.

  12. Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts.

    PubMed

    Perez, C; Jukica, A; Listopad, J J; Anders, K; Kühl, A A; Loddenkemper, C; Blankenstein, T; Charo, J

    2015-07-15

    Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo bioluminescent imaging (BLI) of Renilla luciferase (RLuc) expressing T cells to evaluate the ability of adoptively transferred T cells to survive, expand and home to tumor site in vivo. Using this method, termed RT-Rack (Rluc T cell tracking), we followed T-cell response against tumors in vivo. Expansion and homing of adoptively transferred T cells were antigen dependent, but independent of the host immune status. Moreover, we successfully detected T-cell response to small and large tumors, including autochthonous liver tumors. The adoptively transferred T cells were not ignorant or excluded in a partially tolerant host, which expressed low level of the target in the periphery. Using T cell receptor (TCR)-engineered T cells, we showed the ability of these cells to respond in tumor-bearing hosts by expanding and homing to the tumor site. In all these models, the host immune status, the nature of the tumor or of the antigen, the tumor size and the presence of the targeted antigen in the periphery did not prevent the adoptively transferred T cells from responding by expanding and homing to the tumor. However, T cells had higher expression of the inhibitory receptor PD1 and reduced functional activity when a self-antigen was targeted. PMID:25530110

  13. Adoptive transfer of experimental allergic encephalomyelitis: recipient response to myelin basic protein-reactive lymphocytes.

    PubMed

    Bouwer, H G; Hinrichs, D J

    1994-10-01

    We have used adoptive transfer of myelin basic protein (MBP)-reactive lymphocytes in the Lewis rat model of experimental allergic encephalomyelitis (EAE) to identify stages of effector cell development and to investigate the nature of the subsequent recipient response to the transferred cells. Depending on the timing of cell collection, lymph node cells (LNC) obtained from MBP-CFA (MBP emulsified in complete Freund's adjuvant)-immunized donors may directly transfer clinical disease; however, independent of disease development, recipients of LNC develop early onset of clinical disease following immunization of the recipients with MBP-CFA, consistent with the presence of MBP-memory cells in the LNC transfer inoculum. Similarly obtained spleen cells do not directly transfer disease and do not contain MBP-memory cells (as defined by the early onset of clinical disease following MBP-CFA challenge). Spleen cells adoptively transfer clinical disease only following in vitro culture stimulation with antigen or selected mitogens. Recipients of the primary culture-derived encephalitogenic spleen cells also develop an accelerated onset of clinical disease following MBP-CFA challenge, indicative of the presence of MBP-memory cells, and are not vaccinated. Encephalitogenic T cell lines adoptively transfer clinical disease, and in most cases recipients are vaccinated to MBP-CFA-induced active disease, but remain susceptible to adoptively transferred disease. Co-transfer of encephalitogenic T cell line cells with MBP-reactive lymph node or encephalitogenic spleen cells does not alter the vaccination response. We have found that during the process of T cell line development, the vaccinating phenotype is acquired following the second antigen stimulation cycle. These studies also demonstrate that regulation induced by T cell vaccination blocks the development of effector cells from precursor cells and that such regulation is also equally effective in blocking disease development in

  14. Adoptive Transfer of Myeloid-Derived Suppressor Cells and T Cells in a Prostate Cancer Model

    PubMed Central

    Yan, Libo; Xu, Yan

    2016-01-01

    The adoptive transfer of immune cells for cancer, chronic infection, and autoimmunity is an emerging field that has shown promise in recent trials. The transgenic adenocarcinoma mouse prostate (TRAMP) is a classical mouse model of prostate cancer (PCa) and TRAMP cell lines were derived from a TRAMP mouse tumor. TRAMP-C2 is tumorigenic when subcutaneously (s.c.) grafted into syngeneic C57BL/6 host mice (Foster et al., 1997). This protocol will describe the adoptive transfer of purified CD11b+Gr1+ double positive (DP) myeloid-derived suppressor cells (MDSC) and CD3+ T cells in the TRAMP-C2 prostate cancer mouse model in order to establish the intrinsic functionality of these immune cells and to determine their role in tumorigenesis in vivo (Yan et al., 2014).

  15. Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via TLR4 signaling

    PubMed Central

    Paulos, Chrystal M.; Wrzesinski, Claudia; Kaiser,, Andrew; Hinrichs, Christian S.; Chieppa, Marcello; Cassard, Lydie; Palmer, Douglas C.; Boni, Andrea; Muranski, Pawel; Yu, Zhiya; Gattinoni, Luca; Antony, Paul A.; Rosenberg, Steven A.; Restifo, Nicholas P.

    2007-01-01

    Lymphodepletion with total body irradiation (TBI) increases the efficacy of adoptively transferred tumor-specific CD8+ T cells by depleting inhibitory lymphocytes and increasing homeostatic cytokine levels. We found that TBI augmented the function of adoptively transferred CD8+ T cells in mice genetically deficient in all lymphocytes, indicating the existence of another TBI mechanism of action. Additional investigation revealed commensal gut microflora in the mesenteric lymph nodes and elevated LPS levels in the sera of irradiated mice. These findings correlated with increased dendritic cell activation and heightened levels of systemic inflammatory cytokines. Reduction of host microflora using antibiotics, neutralization of serum LPS using polymyxin B, or removal of LPS signaling components using mice genetically deficient in CD14 and TLR4 reduced the beneficial effects of TBI on tumor regression. Conversely, administration of microbial ligand–containing serum or ultrapure LPS from irradiated animals to nonirradiated antibody-lymphodepleted mice enhanced CD8+ T cell activation and improved tumor regression. Administration of ultrapure LPS to irradiated animals further enhanced the number and function of the adoptively transferred cells, leading to long-term cure of mice with large B16F10 tumors and enhanced autoimmune vitiligo. Thus, disruption of the homeostatic balance between the host and microbes can enhance cell-based tumor immunotherapy. PMID:17657310

  16. Effect of Adoptive Transfer or Depletion of Regulatory T Cells on Triptolide-induced Liver Injury

    PubMed Central

    Wang, Xinzhi; Sun, Lixin; Zhang, Luyong; Jiang, Zhenzhou

    2016-01-01

    Objective: The aim of this study is to clarify the role of regulatory T cell (Treg) in triptolide (TP)-induced hepatotoxicity. Methods: Female C57BL/6 mice received either adoptive transfer of Tregs or depletion of Tregs, then underwent TP administration and were sacrificed 24 h after TP administration. Liver injury was determined according to alanine transaminase (ALT) and aspartate transaminase (AST) levels in serum and histopathological change in liver tissue. Hepatic frequencies of Treg cells and the mRNA expression levels of transcription factor Forkhead box P3 and retinoid orphan nuclear receptor γt (RORγt), interleukin-10 (IL-10), suppressor of cytokine signaling (SOCS), and Notch/Notch ligand were investigated. Results: During TP-induced liver injury, hepatic Treg and IL-10 decreased, while T helper 17 cells cell-transcription factor RORγt, SOCS and Notch signaling increased, accompanied with liver inflammation. Adoptive transfer of Tregs ameliorated the severity of TP-induced liver injury, accompanied with increased levels of hepatic Treg and IL-10. Adoptive transfer of Tregs remarkably inhibited the expression of RORγt, SOCS3, Notch1, and Notch3. On the contrary, depletion of Treg cells in TP-administered mice resulted in a notable increase of RORγt, SOCS1, SOCS3, and Notch3, while the Treg and IL-10 of liver decreased. Consistent with the exacerbation of liver injury, higher serum levels of ALT and AST were detected in Treg-depleted mice. Conclusion: These results showed that adoptive transfer or depletion of Tregs attenuated or aggravated TP-induced liver injury, suggesting that Tregs could play important roles in the progression of liver injury. SOCS proteins and Notch signaling affected Tregs, which may contribute to the pathogenesis of TP-induced hepatotoxicity. PMID:27148057

  17. Accelerated type 1 diabetes induction in mice by adoptive transfer of diabetogenic CD4+ T cells.

    PubMed

    Berry, Gregory; Waldner, Hanspeter

    2013-01-01

    The nonobese diabetic (NOD) mouse spontaneously develops autoimmune diabetes after 12 weeks of age and is the most extensively studied animal model of human Type 1 diabetes (T1D). Cell transfer studies in irradiated recipient mice have established that T cells are pivotal in T1D pathogenesis in this model. We describe herein a simple method to rapidly induce T1D by adoptive transfer of purified, primary CD4+ T cells from pre-diabetic NOD mice transgenic for the islet-specific T cell receptor (TCR) BDC2.5 into NOD.SCID recipient mice. The major advantages of this technique are that isolation and adoptive transfer of diabetogenic T cells can be completed within the same day, irradiation of the recipients is not required, and a high incidence of T1D is elicited within 2 weeks after T cell transfer. Thus, studies of pathogenesis and therapeutic interventions in T1D can proceed at a faster rate than with methods that rely on heterogenous T cell populations or clones derived from diabetic NOD mice. PMID:23685789

  18. Adoptive transfer of allergic airway responses with sensitized lymphocytes in BN rats.

    PubMed

    Watanabe, A; Rossi, P; Renzi, P M; Xu, L J; Guttmann, R D; Martin, J G

    1995-07-01

    To evaluate the role of lymphocytes in the pathogenesis of allergic bronchoconstriction, we investigated whether allergic airway responses are adoptively transferred by antigen-primed lymphocytes in Brown Norway (BN) rats. Animals were actively sensitized to ovalbumin (OA) or sham sensitized, and 14 d later mononuclear cells (MNCs) were isolated from intrathoracic lymph nodes, passed through a nylon wool column, and transferred to naive syngeneic rats. Recipients were challenged with aerosolized OA or bovine serum albumin (BSA) (5% wt/vol) and analyzed for changes in lung resistance (RL), airway responsiveness to inhaled methacholine (MCh), and bronchoalveolar lavage (BAL) cells. Recipients of MNCs from sensitized rats responded to OA inhalation and exhibited sustained increases in RL throughout the 8-h observation period, but without usual early airway responses. Recipients of sham-sensitized MNCs or BSA-challenged recipients failed to respond to antigen challenge. At 32 h after OA exposure, airway responsiveness to MCh was increased in four of seven rats that had received sensitized MNCs (p = 0.035). BAL eosinophils increased at 32 h in the recipients of both sensitized and sham-sensitized MNCs. However, eosinophil numbers in BAL were inversely correlated with airway responsiveness in the recipients of sensitized MNCs (r = -0.788, p = 0.036). OA-specific immunoglobulin E (IgE) was undetectable by enzyme-linked immunosorbent assay (ELISA) or passive cutaneous anaphylaxis (PCA) in recipient rats following adoptive transfer. In conclusion, allergic late airway responses (LAR) and cholinergic airway hyperresponsiveness, but not antigen-specific IgE and early responses, were adoptively transferred by antigen-primed lymphocytes in BN rats.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7599864

  19. Antiangiogenic immunotherapy targeting Flk-1, DNA vaccine and adoptive T cell transfer, inhibits ocular neovascularization

    SciTech Connect

    Zhang, Han; Sonoda, Koh-Hei; Hijioka, Kuniaki; Qiao, Hong; Oshima, Yuji; Ishibashi, Tatsuro

    2009-04-17

    Ocular neovascularization (NV) is the primary cause of blindness in a wide range of ocular diseases. The exact mechanism underlying the pathogenesis of ocular NV is not yet well understood, and so there is no satisfactory therapy for ocular NV. Here, we describe a strategy targeting Flk-1, a self-antigen overexpressed on proliferating endothelial cells in ocular NV, by antiangiogenic immunotherapy-DNA vaccine and adoptive T cell therapy. An oral DNA vaccine encoding Flk-1 carried by attenuated Salmonella typhimurium markedly suppressed development of laser-induced choroidal NV. We further demonstrated that adoptive transfer of vaccine-induced CD8{sup +} T cells reduced pathological preretinal NV, with a concomitant facilitation of physiological revascularization after oxygen-induced retinal vessel obliteration. However, physiological retinal vascular development was unaffected in neonatal mice transferred with vaccine-induced CD8{sup +} T cells. These findings suggested that antiangiogenic immunotherapy targeting Flk-1 such as vaccination and adoptive immunotherapy may contribute to future therapies for ocular NV.

  20. Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells

    PubMed Central

    Liu, Ting; Ren, Jun; Wang, Wei; Wei, Xia-wei; Shen, Guo-bo; Liu, Yan-tong; Luo, Min; Xu, Guang-chao; Shao, Bin; Deng, Sen-yi; He, Zhi-yao; Liang, Xiao; Liu, Yu; Wen, Yan-Zhu; Xiang, Rong; Yang, Li; Deng, Hong-xin; Wei, Yu-quan

    2015-01-01

    The adoptive transfer of the natural regulatory B cells and macrophages should be a useful treatment for inflammation and autoimmune disease. However, it is usually difficult to isolate these cells from the tissues and expand them. Here, we investigated the feasibility of adoptively transferring peritoneal cells (PCs) as a treatment for DSS-induced colitis. We found that peritoneal cavity can provide an easily accessible site for harvesting enough number of PCs, namely, two-dose PCs for the treatment from a mouse in one operation. Adoptive therapy of these cells from healthy mice or those with disease is effectively in reducing the disease activity score. The natural B cells and macrophages of the infused PCs can selectively migrate to lesion sites and regulate the expression of Stat3, NF−κB, Smad3 and Smad7. Additionally, PCs exert dual activity of IL-10 and TGF-β secreted spontaneously by both peritoneal B cells and macrophages, which in turn enhance the induction of regulatory B cells and Macrophages in microenvironment of inflammation. Moreover, PCs can re-establish immunological tolerance in the OVA-immunized mice. Thus, our findings provide a new strategy for colitis therapy and could be of importance in additional exploration of other inflammation and autoimmune diseases therapy. PMID:26565726

  1. Adoptive transfer of natural antibodies to non-immunized chickens affects subsequent antigen-specific humoral and cellular immune responses.

    PubMed

    Lammers, Aart; Klomp, Marcel E V; Nieuwland, Mike G B; Savelkoul, Huub F J; Parmentier, Henk K

    2004-01-01

    To determine a regulatory function of natural antibodies in the immune response of chickens, pooled plasma obtained from non-immunized (naïve) 15 months old hens was subjected to keyhole limpet hemocyanin (KLH) antigen-affinity chromatography. Purified KLH-binding antibodies were adoptively transferred intravenously to 5 weeks-old cocks that were subsequently immunized subcutaneously 24 h later with KLH. Control groups consisted of birds that were either adoptively transferred with KLH-binding antibodies purified from plasma of KLH-immunized chickens, or PBS, or a salt precipitated total immunoglobulin fraction obtained from the corresponding pooled nai;ve chicken plasma, respectively.Total, IgM and IgY antibody titers to KLH in the plasma of recipients adoptively transferred with KLH-NAb, but not in the plasma of the groups transferred with salt precipitate or KLH-binding specific antibodies, were significantly enhanced as compared to the non-treated, KLH immunized group. Titers of IgA antibodies binding KLH were decreased in the plasma of the group that received specific KLH-binding antibodies, but not in the plasma of the other groups. Proliferation from peripheral blood leucocytes in whole blood from the KLH-NAb treated group, the group treated with KLH-binding specific antibodies and the group treated with salt precipitate, respectively, to both concanavalin A and KLH were significantly decreased as compared to the group receiving PBS. Our data show that antigen-specific antibodies can be isolated from plasma obtained from non-immunized chickens. Such antibodies that resemble natural antibodies as described in mammals may perform an important role in the enhancement of subsequent antigen-specific antibody responses or the maturation of the immune system, which may differ from the role of specific antibodies. PMID:12962982

  2. The role of privacy protection in healthcare information systems adoption.

    PubMed

    Hsu, Chien-Lung; Lee, Ming-Ren; Su, Chien-Hui

    2013-10-01

    Privacy protection is an important issue and challenge in healthcare information systems (HISs). Recently, some privacy-enhanced HISs are proposed. Users' privacy perception, intention, and attitude might affect the adoption of such systems. This paper aims to propose a privacy-enhanced HIS framework and investigate the role of privacy protection in HISs adoption. In the proposed framework, privacy protection, access control, and secure transmission modules are designed to enhance the privacy protection of a HIS. An experimental privacy-enhanced HIS is also implemented. Furthermore, we proposed a research model extending the unified theory of acceptance and use of technology by considering perceived security and information security literacy and then investigate user adoption of a privacy-enhanced HIS. The experimental results and analyses showed that user adoption of a privacy-enhanced HIS is directly affected by social influence, performance expectancy, facilitating conditions, and perceived security. Perceived security has a mediating effect between information security literacy and user adoption. This study proposes several implications for research and practice to improve designing, development, and promotion of a good healthcare information system with privacy protection. PMID:24014266

  3. Factors Critical to the Adoption of Career Guidance Systems.

    ERIC Educational Resources Information Center

    Kester, Ralph J.; Howard, John, Jr.

    The study endeavors to describe, assess, and trace the progress of six high schools as the faculty and staff responded to the adoption of an innovative career guidance system. The study provides a model, a method, and some generalizations about factors influencing the process. The document is organized according to: (1) definitions of basic…

  4. Online System Adoption and K-12 Academic Outcomes

    ERIC Educational Resources Information Center

    Kimmons, R.

    2015-01-01

    This study seeks to understand the relationship between K-12 online system adoption (e.g., Blackboard, Edmodo, WordPress) and school-level academic achievement ratings. Utilizing a novel approach to data collection via website data extraction and indexing of all school websites in a target state in the United States (n?=?732) and merging these…

  5. Perceived Attributes Predict Course Management System Adopter Status

    ERIC Educational Resources Information Center

    Keesee, Gayla S.; Shepard, MaryFriend

    2011-01-01

    This quantitative, nonexperimental study utilized Rogers's diffusion of innovation theory as the theoretical base to determine instructors' perceptions of the attributes (relative advantage, compatibility, complexity, trialability, observability) of the course management system used in order to predict adopter status. The study used a convenience…

  6. Heat transfer in aeropropulsion systems

    NASA Astrophysics Data System (ADS)

    Simoneau, R. J.

    1985-07-01

    Aeropropulsion heat transfer is reviewed. A research methodology based on a growing synergism between computations and experiments is examined. The aeropropulsion heat transfer arena is identified as high Reynolds number forced convection in a highly disturbed environment subject to strong gradients, body forces, abrupt geometry changes and high three dimensionality - all in an unsteady flow field. Numerous examples based on heat transfer to the aircraft gas turbine blade are presented to illustrate the types of heat transfer problems which are generic to aeropropulsion systems. The research focus of the near future in aeropropulsion heat transfer is projected.

  7. Heat transfer in aeropropulsion systems

    NASA Technical Reports Server (NTRS)

    Simoneau, R. J.

    1985-01-01

    Aeropropulsion heat transfer is reviewed. A research methodology based on a growing synergism between computations and experiments is examined. The aeropropulsion heat transfer arena is identified as high Reynolds number forced convection in a highly disturbed environment subject to strong gradients, body forces, abrupt geometry changes and high three dimensionality - all in an unsteady flow field. Numerous examples based on heat transfer to the aircraft gas turbine blade are presented to illustrate the types of heat transfer problems which are generic to aeropropulsion systems. The research focus of the near future in aeropropulsion heat transfer is projected.

  8. Nations Adopt Framework Document for Earth Observation System

    NASA Astrophysics Data System (ADS)

    Showstack, Randy

    2004-05-01

    Forty-seven countries and the European Commission adopted a framework document to develop a 10-year implementation plan for a Global Earth Observation System of Systems (GEOSS) .It was signed at a 25 April summit in Tokyo. The framework document envisions the GEOSS as a comprehensive, coordinated, and sustained system that will help to better understand Earth systems, including weather, climate, oceans, geology, and ecosystems. An improved understanding could help to enhance human and environmental well-being, improve the management of energy, water, and other natural resources, and mitigate the impacts of natural disasters and of climate variability and change, according to the document.

  9. Sodium heat transfer system modeling

    NASA Astrophysics Data System (ADS)

    Baker, A. F.; Fewell, M. E.

    1983-11-01

    The sodium heat transfer system of the international energy agency (IEA) small solar power systems (SSPS) central receiver system (CRS), which includes the heliostat field, receiver, hot and cold storage vessels, and sodium/water steam generator was modeled. The computer code SOLTES (simulator of large thermal energy systems), was used to model this system. The results from SOLTES are compared to measured data.

  10. Canister Transfer System Description Document

    SciTech Connect

    2000-10-12

    The Canister Transfer System receives transportation casks containing large and small disposable canisters, unloads the canisters from the casks, stores the canisters as required, loads them into disposal containers (DCs), and prepares the empty casks for re-shipment. Cask unloading begins with cask inspection, sampling, and lid bolt removal operations. The cask lids are removed and the canisters are unloaded. Small canisters are loaded directly into a DC, or are stored until enough canisters are available to fill a DC. Large canisters are loaded directly into a DC. Transportation casks and related components are decontaminated as required, and empty casks are prepared for re-shipment. One independent, remotely operated canister transfer line is provided in the Waste Handling Building System. The canister transfer line consists of a Cask Transport System, Cask Preparation System, Canister Handling System, Disposal Container Transport System, an off-normal canister handling cell with a transfer tunnel connecting the two cells, and Control and Tracking System. The Canister Transfer System operating sequence begins with moving transportation casks to the cask preparation area with the Cask Transport System. The Cask Preparation System prepares the cask for unloading and consists of cask preparation manipulator, cask inspection and sampling equipment, and decontamination equipment. The Canister Handling System unloads the canister(s) and places them into a DC. Handling equipment consists of a bridge crane/hoist, DC loading manipulator, lifting fixtures, and small canister staging racks. Once the cask has been unloaded, the Cask Preparation System decontaminates the cask exterior and returns it to the Carrier/Cask Handling System via the Cask Transport System. After the DC is fully loaded, the Disposal Container Transport System moves the DC to the Disposal Container Handling System for welding. To handle off-normal canisters, a separate off-normal canister handling

  11. CANISTER TRANSFER SYSTEM DESCRIPTION DOCUMENT

    SciTech Connect

    B. Gorpani

    2000-06-23

    The Canister Transfer System receives transportation casks containing large and small disposable canisters, unloads the canisters from the casks, stores the canisters as required, loads them into disposal containers (DCs), and prepares the empty casks for re-shipment. Cask unloading begins with cask inspection, sampling, and lid bolt removal operations. The cask lids are removed and the canisters are unloaded. Small canisters are loaded directly into a DC, or are stored until enough canisters are available to fill a DC. Large canisters are loaded directly into a DC. Transportation casks and related components are decontaminated as required, and empty casks are prepared for re-shipment. One independent, remotely operated canister transfer line is provided in the Waste Handling Building System. The canister transfer line consists of a Cask Transport System, Cask Preparation System, Canister Handling System, Disposal Container Transport System, an off-normal canister handling cell with a transfer tunnel connecting the two cells, and Control and Tracking System. The Canister Transfer System operating sequence begins with moving transportation casks to the cask preparation area with the Cask Transport System. The Cask Preparation System prepares the cask for unloading and consists of cask preparation manipulator, cask inspection and sampling equipment, and decontamination equipment. The Canister Handling System unloads the canister(s) and places them into a DC. Handling equipment consists of a bridge crane hoist, DC loading manipulator, lifting fixtures, and small canister staging racks. Once the cask has been unloaded, the Cask Preparation System decontaminates the cask exterior and returns it to the Carrier/Cask Handling System via the Cask Transport System. After the DC is fully loaded, the Disposal Container Transport System moves the DC to the Disposal Container Handling System for welding. To handle off-normal canisters, a separate off-normal canister handling

  12. The clinical adoption meta-model: a temporal meta-model describing the clinical adoption of health information systems

    PubMed Central

    2014-01-01

    Health information systems (HISs) hold the promise to transform health care; however, their adoption is challenged. We have developed the Clinical Adoption Meta-Model (CAMM) to help describe processes and possible challenges with clinical adoption. The CAMM, developed through an action research study to evaluate a provincial HIS, is a temporal model with four dimensions: availability, use, behaviour changes, and outcome changes. Seven CAMM archetypes are described, illustrating classic trajectories of adoption of HISs over time. Each archetype includes an example from the literature. The CAMM and its archetypes can support HIS implementers, evaluators, learners, and researchers. PMID:24884588

  13. The clinical adoption meta-model: a temporal meta-model describing the clinical adoption of health information systems.

    PubMed

    Price, Morgan; Lau, Francis

    2014-01-01

    Health information systems (HISs) hold the promise to transform health care; however, their adoption is challenged. We have developed the Clinical Adoption Meta-Model (CAMM) to help describe processes and possible challenges with clinical adoption. The CAMM, developed through an action research study to evaluate a provincial HIS, is a temporal model with four dimensions: availability, use, behaviour changes, and outcome changes. Seven CAMM archetypes are described, illustrating classic trajectories of adoption of HISs over time. Each archetype includes an example from the literature. The CAMM and its archetypes can support HIS implementers, evaluators, learners, and researchers. PMID:24884588

  14. Adoption of Clinical Information Systems in Health Services Organizations

    PubMed Central

    Austin, Charles J.; Holland, Gloria J.

    1988-01-01

    This paper presents a conceptual model of factors which influence organizational decisions to invest in the installation of clinical information systems. Using results of previous research as a framework, the relative influence of clinical, fiscal, and strategic-institutional decision structures are examined. These adoption decisions are important in health services organizations because clinical information is essential for managing demand and allocating resources, managing quality of care, and controlling costs.

  15. ENERGY-TRANSFER SYSTEMS

    DOEpatents

    Thonemann, P.C.; Cowhig, W.T.; Davenport, P.A.

    1963-04-01

    This patent relates to the transfer of energy in a traveling electromagnetic wave to direct-current electrical energy in a gaseous medium. The traveling wave is generated by means of a radio-frequency oscillator connected across a capacitance-loaded helix wound around a sealed tube enclosing the gaseous medium. The traveling wave causes the electrons within the medium to drift towards one end of the tube. The direct current appearing across electrodes placed at each end of the tube is then used by some electrical means. (AEC)

  16. Motivations for enterprise system adoption in transition economies: insights from Poland

    NASA Astrophysics Data System (ADS)

    Soja, Piotr; Weistroffer, Heinz Roland

    2016-06-01

    Enterprise system (ES) adoption can bring many benefits, but may also put tremendous strain on an organisation or business, sometimes with disastrous outcomes. The specific motivations and expectations that lead to ES adoption may impact the success or failure of these endeavours, and understanding these motivations may be useful in predicting the success of ES projects. Most of the published research on ES adoption motivation has been in the context of highly developed countries. The social, cultural, economic and political conditions in developing, emerging and transition economies make for a different business environment, and insights obtained from developed countries may not always transfer to these settings. This study seeks to identify and help understand the motivations for ES adoption specifically in transition economies, as these economies play a significant role in the global market, but have not been receiving adequate research attention. Drawing on the experience of 129 ES adopters in Poland, a transition economy, this study categorises motivations into coherent groups of issues and evaluates the influence of discovered motivations on ES adoption success. Further, motivations revealed by this study are compared with motivations reported by prior research conducted in developed countries.

  17. ASSEMBLY TRANSFER SYSTEM DESCRIPTION DOCUMENT

    SciTech Connect

    B. Gorpani

    2000-06-26

    The Assembly Transfer System (ATS) receives, cools, and opens rail and truck transportation casks from the Carrier/Cask Handling System (CCHS). The system unloads transportation casks consisting of bare Spent Nuclear Fuel (SNF) assemblies, single element canisters, and Dual Purpose Canisters (DPCs). For casks containing DPCs, the system opens the DPCs and unloads the SNF. The system stages the assemblies, transfer assemblies to and from fuel-blending inventory pools, loads them into Disposal Containers (DCs), temporarily seals and inerts the DC, decontaminates the DC and transfers it to the Disposal Container Handling System. The system also prepares empty casks and DPCs for off-site shipment. Two identical Assembly Transfer System lines are provided in the Waste Handling Building (WHB). Each line operates independently to handle the waste transfer throughput and to support maintenance operations. Each system line primarily consists of wet and dry handling areas. The wet handling area includes a cask transport system, cask and DPC preparation system, and a wet assembly handling system. The basket transport system forms the transition between the wet and dry handling areas. The dry handling area includes the dry assembly handling system, assembly drying system, DC preparation system, and DC transport system. Both the wet and dry handling areas are controlled by the control and tracking system. The system operating sequence begins with moving transportation casks to the cask preparation area. The cask preparation operations consist of cask cavity gas sampling, cask venting, cask cool-down, outer lid removal, and inner shield plug lifting fixture attachment. Casks containing bare SNF (no DPC) are filled with water and placed in the cask unloading pool. The inner shield plugs are removed underwater. For casks containing a DPC, the cask lid(s) is removed, and the DPC is penetrated, sampled, vented, and cooled. A DPC lifting fixture is attached and the cask is placed

  18. Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury.

    PubMed

    Ma, Shan-Feng; Chen, Yue-Juan; Zhang, Jing-Xing; Shen, Lin; Wang, Rui; Zhou, Jian-Sheng; Hu, Jian-Guo; Lü, He-Zuo

    2015-03-01

    Classically activated pro-inflammatory (M1) and alternatively activated anti-inflammatory (M2) macrophages populate the local microenvironment after spinal cord injury (SCI). The former type is neurotoxic while the latter has positive effects on neuroregeneration and is less toxic. In addition, while the M1 macrophage response is rapidly induced and sustained, M2 induction is transient. A promising strategy for the repair of SCI is to increase the fraction of M2 cells and prolong their residence time. This study investigated the effect of M2 macrophages induced from bone marrow-derived macrophages on the local microenvironment and their possible role in neuroprotection after SCI. M2 macrophages produced anti-inflammatory cytokines such as interleukin (IL)-10 and transforming growth factor β and infiltrated into the injured spinal cord, stimulated M2 and helper T (Th)2 cells, and produced high levels of IL-10 and -13 at the site of injury. M2 cell transfer decreased spinal cord lesion volume and resulted in increased myelination of axons and preservation of neurons. This was accompanied by significant locomotor improvement as revealed by Basso, Beattie and Bresnahan locomotor rating scale, grid walk and footprint analyses. These results indicate that M2 adoptive transfer has beneficial effects for the injured spinal cord, in which the increased number of M2 macrophages causes a shift in the immunological response from Th1- to Th2-dominated through the production of anti-inflammatory cytokines, which in turn induces the polarization of local microglia and/or macrophages to the M2 subtype, and creates a local microenvironment that is conducive to the rescue of residual myelin and neurons and preservation of neuronal function. PMID:25476600

  19. Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model.

    PubMed

    Galvan, Daniel L; O'Neil, Richard T; Foster, Aaron E; Huye, Leslie; Bear, Adham; Rooney, Cliona M; Wilson, Matthew H

    2015-01-01

    Adoptive transfer of gene modified T cells provides possible immunotherapy for patients with cancers refractory to other treatments. We have previously used the non-viral piggyBac transposon system to gene modify human T cells for potential immunotherapy. However, these previous studies utilized adoptive transfer of modified human T cells to target cancer xenografts in highly immunodeficient (NOD-SCID) mice that do not recapitulate an intact immune system. Currently, only viral vectors have shown efficacy in permanently gene-modifying mouse T cells for immunotherapy applications. Therefore, we sought to determine if piggyBac could effectively gene modify mouse T cells to target cancer cells in a mouse cancer model. We first demonstrated that we could gene modify cells to express murine interleukin-12 (p35/p40 mIL-12), a transgene with proven efficacy in melanoma immunotherapy. The OT-I melanoma mouse model provides a well-established T cell mediated immune response to ovalbumin (OVA) positive B16 melanoma cells. B16/OVA melanoma cells were implanted in wild type C57Bl6 mice. Mouse splenocytes were isolated from C57Bl6 OT-I mice and were gene modified using piggyBac to express luciferase. Adoptive transfer of luciferase-modified OT-I splenocytes demonstrated homing to B16/OVA melanoma tumors in vivo. We next gene-modified OT-I cells to express mIL-12. Adoptive transfer of mIL-12-modified mouse OT-I splenocytes delayed B16/OVA melanoma tumor growth in vivo compared to control OT-I splenocytes and improved mouse survival. Our results demonstrate that the piggyBac transposon system can be used to gene modify splenocytes and mouse T cells for evaluating adoptive immunotherapy strategies in immunocompetent mouse tumor models that may more directly mimic immunotherapy applications in humans. PMID:26473608

  20. Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model

    PubMed Central

    Foster, Aaron E.; Huye, Leslie; Bear, Adham; Rooney, Cliona M.; Wilson, Matthew H.

    2015-01-01

    Adoptive transfer of gene modified T cells provides possible immunotherapy for patients with cancers refractory to other treatments. We have previously used the non-viral piggyBac transposon system to gene modify human T cells for potential immunotherapy. However, these previous studies utilized adoptive transfer of modified human T cells to target cancer xenografts in highly immunodeficient (NOD-SCID) mice that do not recapitulate an intact immune system. Currently, only viral vectors have shown efficacy in permanently gene-modifying mouse T cells for immunotherapy applications. Therefore, we sought to determine if piggyBac could effectively gene modify mouse T cells to target cancer cells in a mouse cancer model. We first demonstrated that we could gene modify cells to express murine interleukin-12 (p35/p40 mIL-12), a transgene with proven efficacy in melanoma immunotherapy. The OT-I melanoma mouse model provides a well-established T cell mediated immune response to ovalbumin (OVA) positive B16 melanoma cells. B16/OVA melanoma cells were implanted in wild type C57Bl6 mice. Mouse splenocytes were isolated from C57Bl6 OT-I mice and were gene modified using piggyBac to express luciferase. Adoptive transfer of luciferase-modified OT-I splenocytes demonstrated homing to B16/OVA melanoma tumors in vivo. We next gene-modified OT-I cells to express mIL-12. Adoptive transfer of mIL-12-modified mouse OT-I splenocytes delayed B16/OVA melanoma tumor growth in vivo compared to control OT-I splenocytes and improved mouse survival. Our results demonstrate that the piggyBac transposon system can be used to gene modify splenocytes and mouse T cells for evaluating adoptive immunotherapy strategies in immunocompetent mouse tumor models that may more directly mimic immunotherapy applications in humans. PMID:26473608

  1. Systems of donor transfer.

    PubMed

    de Charro, F T; Akveld, H E; Hessing, D J

    1993-10-01

    The development of medical knowledge has resulted in a demand in society for donor organs, but the recruitment of donor organs for transplantation is difficult. This paper aims to provide some general insights into the complex interaction processes involved. A laissez-faire policy, in which market forces are relied on, is not acceptable from an ethical and legal point of view in most western European countries. Especially at the demand side of the exchange of donor organs, commercialism is to be opposed. We judge the use of commercial incentives at the supply side less unacceptable in theory but not feasible in western European countries. Since market forces are deemed unacceptable as instruments for coordinating demand and supply of donor organs, donor procurement has to be considered as a collective good, and therefore governments are faced with the responsibility of making sure that alternative interaction and distribution mechanisms function. The role of organ procurement agencies (OPAs) in societal interaction concerning postmortem organ donation is described using a two-dimensional conceptualisation scheme. Medical aspects of living organ donation are described. An international comparative description of legal systems to regulate living organ donation in western European countries completes this survey. PMID:10129766

  2. Cutting Edge: Induction of Inflammatory Disease by Adoptive Transfer of an Atypical NK Cell Subset.

    PubMed

    Voynova, Elisaveta; Qi, Chen-Feng; Scott, Bethany; Bolland, Silvia

    2015-08-01

    Several mouse models of systemic lupus erythematosus, including FcγRIIB-KO and TLR7tg mice, develop an expansion of an atypical NK cell subset with functional similarity to cells referred as IFN-producing killer DCs or pre-mature NKs in other systems. In this study, we show that atypical NKs purified from spleens of systemic lupus erythematosus-prone mice, and identified as NK1.1(+)CD11c(+)CD122(+)MHC-II(+), induce persistent autoimmune disease in an IFN-I- and CD40L-dependent manner when transferred to wild-type mice. A single transfer of 4 × 10(6) NK1.1(+) cells from TLR7tg into wild-type induces a 2-wk-long wave of inflammatory cytokines in the serum; a sustained increase in T cell activation and follicular helper cells for the following months; and a progressive expansion of dendritic cells, monocytes, and granulocytes. Furthermore, IL-15 deficiency, which impedes development of NK cells, ameliorates the autoimmune pathology of TLR7tg mice. These results suggest that cells of the NK lineage can develop into cytokine-producing/APCs that affect the priming and progression of systemic autoimmune disease. PMID:26109646

  3. Passive adoptive transfer of antitumor immunity induced by laser-dye-immunoadjuvant treatment in a rat metastatic breast cancer model

    NASA Astrophysics Data System (ADS)

    Chen, Wei R.; Liu, Hong; Singhal, Anil K.; Nordquist, Robert E.

    2000-06-01

    The ideal cancer treatment modalities should not only cause tumor regression and eradication but also induce a systemic anti-tumor immunity. This is essential for control of metastatic tumors and for long-term tumor resistance. Laser immunotherapy using a laser, a laser-absorbing dye and an immunoadjuvant has induced such a long-term immunity in treatment of a mammary metastatic tumor. The successfully treated rats established total resistance to multiple subsequent tumor challenges. For further mechanistic studies of the antitumor immunity induced by this novel treatment modality, passive adoptive transfer was performed using splenocytes as immune cells. The spleen cells harvested from successfully treated tumor-bearing rats provided 100% immunity in the naive recipients. The passively protected first cohort rats were immune to tumor challenge with an increased tumor dose; their splenocytes also prevented the establishment of tumor in the second cohort of naive recipient rats. This immunity transfer was accomplished without the usually required T-cell suppression in recipients.

  4. Irradiated lymphocytes do not adoptively transfer diabetes or prevent spontaneous disease in the BB/W rat

    SciTech Connect

    Mordes, J.P.; Handler, E.S.; Like, A.A.; Nakano, K.; Rossini, A.A.

    1986-06-01

    Diabetes in the BB/W rat is autoimmune in origin, and lymphocytes from acutely diabetic animals activated by concanavalin A (con A) induce the disease in adoptive recipients. We report that irradiation of these cells prevents adoptive transfer of diabetes. Through 60 days of age, diabetes occurred in none of 47 BB/W rats given irradiated con A cells, but in 21 of 36 (58%) given nonirradiated cells. Between 60 and 130 days of age, however, spontaneous diabetes occurred in 18 of 34 untreated control rats (53%) and 16 of 32 rats (50%) given two injections of irradiated con A activated spleen cells. We conclude that irradiation prevents adoptive transfer of BB/W rat diabetes and that irradiated con A activated lymphocytes from acutely diabetic rats do not protect against spontaneous disease in susceptible recipients.

  5. MUC1-specific cytotoxic T lymphocytes eradicate tumors when adoptively transferred in vivo.

    PubMed

    Mukherjee, P; Ginardi, A R; Tinder, T L; Sterner, C J; Gendler, S J

    2001-03-01

    We have reported previously that MUC1 transgenic mice with spontaneous tumors of the pancreas (designated MET) naturally develop MHC class I-restricted, MUC1-specific CTLs as tumors progress (P. Mukherjee et al., J. Immunol., 165: 3451-3460, 2000). From these MET mice, we have isolated, expanded, and cloned naturally occurring MUC1-specific CTLs in vitro. In this report, we show that the CTL line is predominantly CD8+ T cells and expresses T-cell receptor Vbeta chains 5.1/5.2, 11, 13, and 2 and Valpha chains 2, 8.3, 3.2, and 11.1/11.2. These CTLs recognize several epitopes on the MUC1 tandem repeat with highest affinity to APGSTAPPA. The CTL clone, on the other hand, is 100% CD8+ cells and expresses a single Vbeta chain of 5.1/5.2 and Valpha2. It recognizes only the H-2Db class I-restricted epitope of MUC1, APGSTAPPA. When adoptively transferred, the CTLs were effective in eradicating MUC1-expressing injected tumor cells including mammary gland cells (C57mg) and B16 melanomas. These results suggest that MUC1-specific CTLs are capable of possibly preventing, or at least substantially delaying, MUC1-expressing tumor formation. To our knowledge, this is the first evidence that demonstrates that the naturally occurring MUC1-specific CTLs isolated from one tumor model has antitumor effects on other MUC1-expressing tumors in vivo. Therefore, our data confirm that MUC1 is an important tumor rejection antigen and can serve as a target for immunotherapy. PMID:11300482

  6. Induction of autoimmune disease by adoptive transfer of an atypical NK cell subset

    PubMed Central

    Voynova, Elisaveta; Qi, Chen-Feng; Scott, Bethany; Bolland, Silvia

    2015-01-01

    Several mouse models of SLE, including FcγRIIB-KO and TLR7tg mice, develop an expansion of an atypical NK cell subset with functional similarity to cells referred as IKDCs or pre-mNKs in other systems. Here we show that atypical NKs purified from spleens of SLE-prone mice, and identified as NK1.1+CD11c+CD122+MHC-II+, induce persistent autoimmune disease in an IFN-I and CD40L-dependent manner when transferred to WT mice. A single transfer of 4x106 NK1.1+ cells from TLR7tg into WT induces a 2-week-long wave of inflammatory cytokines in the serum, a sustained increase in T cell activation and follicular helper cells for the following months, and a progressive expansion of dendritic cells, monocytes and granulocytes. Furthermore IL15 deficiency, which impedes development of NK cells, ameliorates the autoimmune pathology of TLR7tg mice. These results suggest that cells of the NK lineage can develop into cytokine producing/antigen-presenting cells that affect the priming and progression of systemic autoimmune disease. PMID:26109646

  7. Adoption of the Q transcriptional regulatory system for zebrafish transgenesis

    PubMed Central

    Subedi, Abhignya; Macurak, Michelle; Gee, Stephen T.; Monge, Estela; Goll, Mary G.; Potter, Christopher J.; Parsons, Michael J.; Halpern, Marnie E.

    2013-01-01

    The Gal4-UAS regulatory system of yeast is widely used to modulate gene expression in Drosophila; however, there are limitations to its usefulness in transgenic zebrafish, owing to progressive methylation and silencing of the CpG-rich multicopy upstream activation sequence. Although a modified, less repetitive UAS construct may overcome this problem, it is highly desirable to have additional transcriptional regulatory systems that can be applied independently or in combination with the Gal4/UAS system for intersectional gene expression. The Q transcriptional regulatory system of Neurospora crassa functions similarly to Gal4/UAS. QF is a transcriptional activator that binds to the QUAS upstream regulatory sequence to drive reporter gene expression. Unlike Gal4, the QF binding site does not contain essential CpG dinucleotide sequences that are subject to DNA methylation. The QS protein is a repressor of QF mediated transcriptional activation akin to Gal80. The functionality of the Q system has been demonstrated in Drosophila and C. elegans and we now report its successful application to a vertebrate model, the zebrafish, Danio rerio. Several tissue-specific promoters were used to drive QF expression in stable transgenic lines, as assessed by activation of a QUAS:GFP transgene. The QS repressor was found to dramatically reduce QF activity in injected zebrafish embryos; however, a similar repression has not yet been achieved in transgenic animals expressing QS under the control of ubiquitous promoters. A dual reporter construct containing both QUAS and UAS, each upstream of different fluorescent proteins was also generated and tested in transient assays, demonstrating that the two systems can work in parallel within the same cell. The adoption of the Q system should greatly increase the versatility and power of transgenic approaches for regulating gene expression in zebrafish. PMID:23792917

  8. Adoption of Geospatial Systems towards evolving Sustainable Himalayan Mountain Development

    NASA Astrophysics Data System (ADS)

    Murthy, M. S. R.; Bajracharya, B.; Pradhan, S.; Shestra, B.; Bajracharya, R.; Shakya, K.; Wesselmann, S.; Ali, M.; Bajracharya, S.; Pradhan, S.

    2014-11-01

    Natural resources dependence of mountain communities, rapid social and developmental changes, disaster proneness and climate change are conceived as the critical factors regulating sustainable Himalayan mountain development. The Himalayan region posed by typical geographic settings, diverse physical and cultural diversity present a formidable challenge to collect and manage data, information and understands varied socio-ecological settings. Recent advances in earth observation, near real-time data, in-situ measurements and in combination of information and communication technology have transformed the way we collect, process, and generate information and how we use such information for societal benefits. Glacier dynamics, land cover changes, disaster risk reduction systems, food security and ecosystem conservation are a few thematic areas where geospatial information and knowledge have significantly contributed to informed decision making systems over the region. The emergence and adoption of near-real time systems, unmanned aerial vehicles (UAV), board-scale citizen science (crowd-sourcing), mobile services and mapping, and cloud computing have paved the way towards developing automated environmental monitoring systems, enhanced scientific understanding of geophysical and biophysical processes, coupled management of socio-ecological systems and community based adaptation models tailored to mountain specific environment. There are differentiated capacities among the ICIMOD regional member countries with regard to utilization of earth observation and geospatial technologies. The region can greatly benefit from a coordinated and collaborative approach to capture the opportunities offered by earth observation and geospatial technologies. The regional level data sharing, knowledge exchange, and Himalayan GEO supporting geospatial platforms, spatial data infrastructure, unique region specific satellite systems to address trans-boundary challenges would go a long way in

  9. Adoptive Transfer of Dendritic Cells Expressing Fas Ligand Modulates Intestinal Inflammation in a Model of Inflammatory Bowel Disease

    PubMed Central

    de Jesus, Edelmarie Rivera; Isidro, Raymond A; Cruz, Myrella L; Marty, Harry; Appleyard, Caroline B

    2016-01-01

    Background Inflammatory bowel diseases (IBD) are chronic relapsing inflammatory conditions of unknown cause and likely result from the loss of immunological tolerance, which leads to over-activation of the gut immune system. Gut macrophages and dendritic cells (DCs) are essential for maintaining tolerance, but can also contribute to the inflammatory response in conditions such as IBD. Current therapies for IBD are limited by high costs and unwanted toxicities and side effects. The possibility of reducing intestinal inflammation with DCs genetically engineered to over-express the apoptosis-inducing FasL (FasL-DCs) has not yet been explored. Objective Investigate the immunomodulatory effect of administering FasL-DCs in the rat trinitrobenzene sulfonic acid (TNBS) model of acute colitis. Methods Expression of FasL on DCs isolated from the mesenteric lymph nodes (MLNs) of normal and TNBS-colitis rats was determined by flow cytometry. Primary rat bone marrow DCs were transfected with rat FasL plasmid (FasL-DCs) or empty vector (EV-DCs). The effect of these DCs on T cell IFNγ secretion and apoptosis was determined by ELISPOT and flow cytometry for Annexin V, respectively. Rats received FasL-DCs or EV-DCs intraperitoneally 96 and 48 hours prior to colitis induction with TNBS. Colonic T cell and neutrophil infiltration was determined by immunohistochemistry for CD3 and myeloperoxidase activity assay, respectively. Macrophage number and phenotype was measured by double immunofluorescence for CD68 and inducible Nitric Oxide Synthase. Results MLN dendritic cells from normal rats expressed more FasL than those from colitic rats. Compared to EV-DCs, FasL-DCs reduced T cell IFNγ secretion and increased T cell apoptosis in vitro. Adoptive transfer of FasL-DCs decreased macroscopic and microscopic damage scores and reduced colonic T cells, neutrophils, and proinflammatory macrophages when compared to EV-DC adoptive transfer. Conclusion FasL-DCs are effective at treating colonic

  10. Comparing decision-support systems in adopting sustainable intensification criteria

    PubMed Central

    Ahmadi, Bouda Vosough; Moran, Dominic; Barnes, Andrew P.; Baret, Philippe V.

    2015-01-01

    Sustainable intensification (SI) is a multifaceted concept incorporating the ambition to increase or maintain the current level of agricultural yields while reduce negative ecological and environmental impacts. Decision-support systems (DSS) that use integrated analytical methods are often used to support decision making processes in agriculture. However, DSS often consist of set of values, objectives, and assumptions that may be inconsistent or in conflict with merits and objectives of SI. These potential conflicts will have consequences for adoption and up-take of agricultural research, technologies and related policies and regulations such as genetic technology in pursuit of SI. This perspective paper aimed at comparing a number of frequently used socio-economic DSS with respect to their capacity in incorporating various dimensions of SI, and discussing their application to analyzing farm animal genetic resources (FAnGR) policies. The case of FAnGR policies was chosen because of its great potential in delivering merits of SI. It was concluded that flexible DSS, with great integration capacity with various natural and social sciences, are needed to provide guidance on feasibility, practicality, and policy implementation for SI. PMID:25717336

  11. Metabolic phenotyping of an adoptive transfer mouse model of experimental colitis and impact of dietary fish oil intake.

    PubMed

    Martin, Francois-Pierre J; Lichti, Pia; Bosco, Nabil; Brahmbhatt, Viral; Oliveira, Manuel; Haller, Dirk; Benyacoub, Jalil

    2015-04-01

    Inflammatory bowel diseases are acute and chronic disabling inflammatory disorders with multiple complex etiologies that are not well-defined. Chronic intestinal inflammation has been linked to an energy-deficient state of gut epithelium with alterations in oxidative metabolism. Plasma-, urine-, stool-, and liver-specific metabonomic analyses are reported in a naïve T cell adoptive transfer (AT) experimental model of colitis, which evaluated the impact of long-chain n-3 polyunsaturated fatty acid (PUFA)-enriched diet. Metabolic profiles of AT animals and their controls under chow diet or fish oil supplementation were compared to describe the (i) consequences of inflammatory processes and (ii) the differential impact of n-3 fatty acids. Inflammation was associated with higher glycoprotein levels (related to acute-phase response) and remodeling of PUFAs. Low triglyceride levels and enhanced PUFA levels in the liver suggest activation of lipolytic pathways that could lead to the observed increase of phospholipids in the liver (including plasmalogens and sphingomyelins). In parallel, the increase in stool excretion of most amino acids may indicate a protein-losing enteropathy. Fecal content of glutamine was lower in AT mice, a feature exacerbated under fish oil intervention that may reflect a functional relationship between intestinal inflammatory status and glutamine metabolism. The decrease in Krebs cycle intermediates in urine (succinate, α-ketoglutarate) also suggests a reduction in the glutaminolytic pathway at a systemic level. Our data indicate that inflammatory status is related to this overall loss of energy homeostasis. PMID:25751005

  12. 40 CFR 35.2208 - Adoption of sewer use ordinance and user charge system.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Adoption of sewer use ordinance and user charge system. 35.2208 Section 35.2208 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... § 35.2208 Adoption of sewer use ordinance and user charge system. The grantee shall adopt its sewer...

  13. 40 CFR 35.2208 - Adoption of sewer use ordinance and user charge system.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Adoption of sewer use ordinance and user charge system. 35.2208 Section 35.2208 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... § 35.2208 Adoption of sewer use ordinance and user charge system. The grantee shall adopt its sewer...

  14. 40 CFR 35.2208 - Adoption of sewer use ordinance and user charge system.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Adoption of sewer use ordinance and user charge system. 35.2208 Section 35.2208 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... § 35.2208 Adoption of sewer use ordinance and user charge system. The grantee shall adopt its sewer...

  15. Adoptive transfer of the generalized lymphoproliferative disease (gld) syndrome in nude beige mice.

    PubMed Central

    Froidevaux, S; Rosenblatt, N; Loor, F

    1992-01-01

    C57BL/6 nude beige mice (B6 nubg) were used as recipients for the transfer of haematopoietic cells from either B6 wild as control mice, or systemic lupus erythematous B6 mice homozygous for the recessive generalized lymphadenopathy disease (gld) locus. Both gld and wild cell grafts prolonged survival of the short-living B6 nubg recipients and restored some T-cell functions, as monitored by the presence of T-dependent Ig isotypes in the serum and responsiveness of spleen cells to a T-cell mitogen. Moreover, the [gld----nubg] chimeras but not the [wild----nubg] chimeras showed several similarities with gld control mice, particularly, a spleen and lymph node hyperplasia, elevated anti-single-stranded DNA antibody titres and a hyperglobulinaemia. This hyperglobulinaemia was however qualitatively different from the gld-type hyperglobulinaemia with an important contribution of the IgG1 isotype; the lymph node hyperplasia was also less marked than in B6 gld mice. PMID:1592442

  16. Adoptive transfer of dendritic cells modulates immunogenesis and tolerogenesis in a neonatal model of murine cutaneous leishmaniasis

    PubMed Central

    Ponce, Loida V; Corado, José; Díaz, Nilka L; Tapia, Felix J

    2005-01-01

    We evaluated the adoptive transfer of DCs on Leishmania (L.) mexicana-infected neonatal BALB/c mice. DCs were isolated and purified from the spleens of the following donor groups: a) Adult BALB/c mice infected during adulthood with L. (L) mexicana; b) Adult BALB/c mice infected during neonatal life; c) Healthy neonatal BALB/c mice; d) Healthy adult BALB/c mice. A neonatal model of infection, generated after inoculation with 5 × 105 promastigotes of L. (L) mexicana, was used as the infection control group. Sixteen hours after intraperitoneal transfer of DCs (1 × 103, 1 × 105, or 1 × 106 cells/ml), neonatal recipient BALB/c mice were infected. The adoptive transfer of DCs diminished disease progression in neonatal mice. This reduction depends on the quantity and provenance of transferred DCs, since the effect was more evident with high numbers of DCs from adult mice infected during adulthood and healthy neonatal mice. Protection was significantly reduced in animals receiving DCs from healthy adult mice but it was absent in mice receiving DCs from adult mice infected during neonatal life. These results suggest that genetic susceptibility to Leishmania infection can be modified during neonatal life, and that the period of life when antigens are encountered is crucial in influencing the capacity of DCs to induce resistance or tolerance. PMID:15670331

  17. Optical fiber data transfer system

    NASA Technical Reports Server (NTRS)

    Mcmillan, S. H.

    1988-01-01

    This Phase 2 effort applies the results of Phase 1 to design and fabricate an optical slip ring system for a helicopter rotor blade/wind tunnel application. In this application, there are two assemblies: one on the rotating portion of the mechanical system, one on the stationary portion. The assembly on the rotating portion digitizes and encodes 128 transducer signals from various parts of the blade, and optically transfers data across the noncontacting coupling. Two complete identical independent channels are provided. On the stationary side, the signals are decoded and one channel is transmitted in digital form to a computer for recording and analysis. The second channel reconstructs the analog transducer signals for real time observation. In the opposite direction, eight signal channels enable control signals to be passed from the stationary to the rotating part of the system. Power to the rotor mounted electronics is supplied via power slip rings. The advantages of the optical over the traditional electro-mechanical slip ring method of data transfer across a rotating joint are long life, low-maintenance, immunity to crosstalk, and wider bandwidth. Successful completion of this effort demonstrated that this method is practical and reliable, and can be implemented under difficult conditions of available space, power, environment, and stringent performance and equipment life requirements.

  18. 77 FR 1555 - Administrative Simplification: Adoption of Standards for Health Care Electronic Funds Transfers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-10

    ... regulatory history, see the August 22, 2008 (73 FR 49742) proposed rule entitled ``Health Insurance Reform..., 2000 Federal Register (65 FR 50312), we published a final rule entitled ``Health Insurance Reform... and 162 Administrative Simplification: Adoption of Standards for Health Care Electronic...

  19. Abacavir hypersensitivity: a model system for pharmacogenetic test adoption.

    PubMed

    Lai-Goldman, Myla; Faruki, Hawazin

    2008-12-01

    A pharmacogenetic marker for abacavir hypersensitivity is rapidly being incorporated into routine medical practice following demonstration of strong clinical utility in pivotal clinical studies. As one of the few pharmacogenetic markers that have crossed from research tools to clinical adoption and utilization, the abacavir hypersensitivity pharmacogenetic marker provides a great model for demonstration of factors that are critical to successful pharmacogenetic test adoption. Several examples of novel diagnostic test implementation are reviewed with focus on factors that are critical to translation into clinical practice. Other pharmacogenetic markers that have not yet been integrated into routine clinical care are discussed and reasons for their lack of acceptance are suggested. PMID:19092439

  20. Smart crane ammunition transfer system

    SciTech Connect

    Bradley, E.C.; Killough, S.M.; Rowe, J.C.

    1995-03-01

    The purpose of the Smart Crane Ammunition Transfer System (SCATS) project is to demonstrate robotic/telerobotic controls technology for a mobile articulated crane for missile/ munitions handling, delivery, and reload. Missile resupply and reload have been manually intensive operations up to this time. Currently, reload missiles are delivered by truck to the site of the launcher. A crew of four to five personnel reloads the missiles from the truck to the launcher using a hydraulic-powered crane. The missiles are handled carefully for the safety of the missiles and personnel. Numerous steps are required in the reload process and the entire reload operation can take over 1 h for some missile systems. Recent U.S. Army directives require the entire operation to be accomplished in a fraction of that time. Current requirements for the development of SCATS are being based primarily on reloading Patriot missiles. The planned development approach will integrate robotic control and sensor technology with a commercially available hydraulic articulated crane. SCATS is being developed with commercially available hardware as much as possible. Development plans include adding a 3-D.F. end effector with a grapple to the articulating crane; closed-loop position control for the crane and end effector; digital microprocessor control of crane functions; simplified operator interface; and operating modes which include rectilinear movement, obstacle avoidance, and partial automated operation. The planned development will include progressive technology demonstrations. Ultimate plans are for this technology to be transferred and utilized in the military fielding process.

  1. Teacher Adoption of a Web-Based Instructional Planning System

    ERIC Educational Resources Information Center

    Saldivar, Manuel Gerardo

    2012-01-01

    Many policymakers, administrators, and other K-12 stakeholders have long advocated the use of computers and information technology in schools. Even in settings where such technologies have been introduced, however, evidence suggests that the impact on student outcomes has been mixed. In some cases, teachers simply do not adopt the new…

  2. Adoption of site-specific variable rate sprinkler irrigation systems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    More than twenty years of private and public research on site-specific variable-rate sprinkler irrigation (SS-VRI) technology has resulted in limited commercial adoption of the technology. Competing patents, liability and proprietary software have affected industry’s willingness to move into a new t...

  3. Enhancing adoption of site-specific variable rate sprinkler systems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    More than twenty years of private and public research on site-specific variable-rate sprinkler irrigation (SS-VRI) has resulted in very limited commercial adoption of the technology. Documented and proven water conservation strategies using site-specific irrigation are quite limited, and its cost-ef...

  4. Waste Feed Delivery Transfer System Analysis

    SciTech Connect

    JULYK, L.J.

    2000-05-05

    This document provides a documented basis for the required design pressure rating and pump pressure capacity of the Hanford Site waste-transfer system in support of the waste feed delivery to the privatization contractor for vitrification. The scope of the analysis includes the 200 East Area double-shell tank waste transfer pipeline system and the associated transfer system pumps for a11 Phase 1B and Phase 2 waste transfers from AN, AP, AW, AY, and A2 Tank Farms.

  5. Interorganizational transfer of technology - A study of adoption of NASA innovations

    NASA Technical Reports Server (NTRS)

    Chakrabarti, A. K.; Rubenstein, A. H.

    1976-01-01

    The paper describes a study on the effects of top management support, various techno-economic factors, organizational climate, and decision-making modes on the adoption of NASA innovations. Field research consisted of interviews and questionnaires directed to sixty-five organizations. Forty-five test cases where different decisions for adoption of ideas for new products or processes were made on NASA Tech Briefs were studied in relation to the effects of various factors on the degree of success of adoption, including: (1) the degree of general connection of the technology to the firm's existing operation, (2) the specificity of the relationship between the technology and some existing and recognized problem, (3) the degree of urgency of the problem to which the technology was related, (4) maturity of technology available to implement the technology, (5) availability of personnel and financial resources to implement the technology, (6) degree of top management interest, (7) the use of confrontation in joint-decision, (8) the use of smoothing in decision-making, and (9) the use of forcing in decision-making. It was found that top managements interest was important in the product cases only, and that the success of process innovations was dependent on the quality of information and the specificity of the relationship between the technology and some recognized existing problem.

  6. The Determinants of the Post-Adoption Satisfaction of Educators with an E-Learning System

    ERIC Educational Resources Information Center

    Islam, A. K. M. Najmul

    2011-01-01

    This paper examines factors that influence the post-adoption satisfaction of educators with e-learning systems. Based on the expectation-confirmation framework, we propose a research model that demonstrates how post-adoption beliefs affect post-adoption satisfaction. The model was tested at a university by educators (n = 175) who use an e-learning…

  7. Electronic Learning Systems in Hong Kong Business Organizations: A Study of Early and Late Adopters

    ERIC Educational Resources Information Center

    Chan, Simon C. H.; Ngai, Eric W. T.

    2012-01-01

    Based on the diffusion of innovation theory (E. M. Rogers, 1983, 1995), the authors examined the antecedents of the adoption of electronic learning (e-learning) systems by using a time-based assessment model (R. C. Beatty, J. P. Shim, & M. C. Jones, 2001), which classified adopters into categories upon point in time when adopting e-learning…

  8. BC Transfer System: New Members Policy

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2009

    2009-01-01

    The mandate of the British Columbia Council on Admissions and Transfer (BCCAT) includes the responsibility to manage and coordinate the British Columbia (BC) Transfer System. Upon its inception in 1989, the Council inherited a Transfer System that included all BC public institutions, Yukon College, and three private institutions. Since then, new…

  9. An Update on the Learning Transfer System

    ERIC Educational Resources Information Center

    Choi, Myungweon; Ruona, Wendy E. A.

    2008-01-01

    Learning transfer in organizations is a central issue in HRD. Much of the research of the 1980-1990's informed the development of the learning transfer system inventory (Holton, Bates, & Ruona, 2000). However, it's vitally important to continually enhance our understanding of the learning transfer system. In this paper, we reviewed the new…

  10. WASTEWATER SAMPLING, TRANSFER AND CONDITIONING SYSTEM

    EPA Science Inventory

    This report describes the construction and field evaluation of an automatic on-line hardware system for reliably sampling, transferring, and conditioning various wastewater-treatment process streams such that the resulting transferred and conditioned samples are suitable for inte...

  11. Dry Transfer Systems for Used Nuclear Fuel

    SciTech Connect

    Brett W. Carlsen; Michaele BradyRaap

    2012-05-01

    The potential need for a dry transfer system (DTS) to enable retrieval of used nuclear fuel (UNF) for inspection or repackaging will increase as the duration and quantity of fuel in dry storage increases. This report explores the uses for a DTS, identifies associated general functional requirements, and reviews existing and proposed systems that currently perform dry fuel transfers. The focus of this paper is on the need for a DTS to enable transfer of bare fuel assemblies. Dry transfer systems for UNF canisters are currently available and in use for transferring loaded canisters between the drying station and storage and transportation casks.

  12. Transfer function characteristics of super resolving systems

    NASA Technical Reports Server (NTRS)

    Milster, Tom D.; Curtis, Craig H.

    1992-01-01

    Signal quality in an optical storage device greatly depends on the optical system transfer function used to write and read data patterns. The problem is similar to analysis of scanning optical microscopes. Hopkins and Braat have analyzed write-once-read-many (WORM) optical data storage devices. Herein, transfer function analysis of magnetooptic (MO) data storage devices is discussed with respect to improving transfer-function characteristics. Several authors have described improving the transfer function as super resolution. However, none have thoroughly analyzed the MO optical system and effects of the medium. Both the optical system transfer function and effects of the medium of this development are discussed.

  13. Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer.

    PubMed

    Bernhard, Helga; Neudorfer, Julia; Gebhard, Kerstin; Conrad, Heinke; Hermann, Christine; Nährig, Jörg; Fend, Falko; Weber, Wolfgang; Busch, Dirk H; Peschel, Christian

    2008-02-01

    The human epidermal growth factor receptor 2 (HER2) has been targeted as a breast cancer-associated antigen by immunotherapeutical approaches based on HER2-directed monoclonal antibodies and cancer vaccines. We describe the adoptive transfer of autologous HER2-specific T-lymphocyte clones to a patient with metastatic HER2-overexpressing breast cancer. The HLA/multimer-based monitoring of the transferred T lymphocytes revealed that the T cells rapidly disappeared from the peripheral blood. The imaging studies indicated that the T cells accumulated in the bone marrow (BM) and migrated to the liver, but were unable to penetrate into the solid metastases. The disseminated tumor cells in the BM disappeared after the completion of adoptive T-cell therapy. This study suggests the therapeutic potential for HER2-specific T cells for eliminating disseminated HER2-positive tumor cells and proposes the combination of T cell-based therapies with strategies targeting the tumor stroma to improve T-cell infiltration into solid tumors. PMID:17646988

  14. Administrative simplification: adoption of operating rules for health care electronic funds transfers (EFT) and remittance advice transactions. Interim final rule with comment period.

    PubMed

    2012-08-10

    This interim final rule with comment period implements parts of section 1104 of the Affordable Care Act which requires the adoption of operating rules for the health care electronic funds transfers (EFT) and remittance advice transaction. PMID:22888504

  15. Administrative simplification: adoption of standards for health care electronic funds transfers (EFTs) and remittance advice. Interim final rule with comment period.

    PubMed

    2012-01-10

    This interim final rule with comment period implements parts of section 1104 of the Affordable Care Act which requires the adoption of a standard for electronic funds transfers (EFT). It defines EFT and explains how the adopted standards support and facilitate health care EFT transmissions. PMID:22359791

  16. Adoptive transfer of resistance to acute Trypanosoma cruzi infection with T-lymphocyte-enriched spleen cells.

    PubMed Central

    Reed, S G

    1980-01-01

    Inbred C57BL/10 mice immunized with live culture forms of Trypanosoma cruzi were resistant to acute infection after challenge with bloodstream forms. Splenic leukocytes or serum from immunized mice were transferred to syngeneic recipients 2 days before of 2 days after challenge. Protection was not observed in recipients of serum, although the serum contained high levels of agglutinating antibody. Unfractionated splenic leukocytes from immunized donors conferred partial protection, and preparations enriched for T lymphocytes were significantly more effective than preparations enriched for B lymphocytes. Recipients of T-lymphocyte-enriched spleen cells had significantly higher survival times and significantly lower parasitemias than did recipients of B-lymphocyte-enriched spleen cells. PMID:6772557

  17. Enhancement of adoptive T cell transfer with single low dose pretreatment of doxorubicin or paclitaxel in mice

    PubMed Central

    Chuang, Hui-Yen; Chang, Ya-Fang; Hwang, Jeng-Jong

    2015-01-01

    Ex vivo expansion of CD8+ T-cells has been a hindrance for the success of adoptive T cell transfer in clinic. Currently, preconditioning with chemotherapy is used to modulate the patient immunity before ACT, however, the tumor microenvironment beneficial for transferring T cells may also be damaged. Here preconditioning with single low dose of doxorubicin or paclitaxel combined with fewer CD8+ T-cells was investigated to verify whether the same therapeutic efficacy of ACT could be achieved. An E.G7/OT1 animal model that involved adoptive transfer of OVA-specific CD8+ T-cells transduced with a granzyme B promoter-driven firefly luciferase and tomato fluorescent fusion reporter gene was used to evaluate this strategy. The result showed that CD8+ T-cells were activated and sustained longer in mice pretreated with one low-dose Dox or Tax. Enhanced therapeutic efficacy was found in Dox or Tax combined with 2×106 CD8+ T-cells and achieved the same level of tumor growth inhibition as that of 5×106 CD8+ T-cells group. Notably, reduced numbers of Tregs and myeloid derived suppressor cells were shown in combination groups. By contrast, the number of tumor-infiltrating cytotoxic T lymphocytes and IL-12 were increased. The NF-κB activity and immunosuppressive factors such as TGF-β, IDO, CCL2, VEGF, CCL22, COX-2 and IL-10 were suppressed. This study demonstrates that preconditioning with single low dose Dox or Tax and combined with two fifth of the original CD8+ T-cells could improve the tumor microenvironment via suppression of NF-κB and its related immunosuppressors, and activate more CD8+ T-cells which also stay longer. PMID:26683520

  18. Looking under the Bonnet: Factors Affecting Student Adoption of E-Learning Systems in Jordan

    ERIC Educational Resources Information Center

    Abbad, Muneer Mahmood; Morris, David; de Nahlik, Carmel

    2009-01-01

    The primary questions addressed in this paper are the following: what are the factors that affect students' adoption of an e-learning system and what are the relationships among these factors? This paper investigates and identifies some of the major factors affecting students' adoption of an e-learning system in a university in Jordan. E-learning…

  19. A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model

    PubMed Central

    Franke, Deanna D.H.; Yolcu, Esma S.; Alard, Pascale; Kosiewicz, Michele M.; Shirwan, Haval

    2007-01-01

    Activation induced cell death (AICD) via Fas/FasL is the primary homeostatic molecular mechanism employed by the immune system to control activated T-cell responses and promote tolerance to self-antigens. We herein investigated the ability of a novel multimeric form of FasL chimeric with streptavidin (SA-FasL) having potent apoptotic activity to induce apoptosis in diabetogenic T cells and modulate insulin-dependent type 1 diabetes (IDDM) in an adoptive transfer model. Diabetogenic splenocytes from NOD/Lt females were co-cultured in vitro with SA-FasL, SA control protein, or alone without protein, and adoptively transferred into NOD/Lt-Rag1null recipients for diabetes development. All animals receiving control (Alone: n=16 or SA: n=17) cells developed diabetes on average by 6 weeks, whereas animals receiving SA-FasL-treated (n = 25) cells exhibited significantly delayed progression (p<.001) and decreased incidence (70%). This effect was associated with an increase in CD4+CD25+ T cells and correlated with FoxP3 expression in pancreatic lymph nodes. Extracorporeal treatment of peripheral blood lymphocytes using SA-FasL during disease onset represents a novel approach that may alter the ability of pathogenic T cells to mediate diabetes and have therapeutic utility in clinical management of IDDM. PMID:17324464

  20. Orbital Express fluid transfer demonstration system

    NASA Astrophysics Data System (ADS)

    Rotenberger, Scott; SooHoo, David; Abraham, Gabriel

    2008-04-01

    Propellant resupply of orbiting spacecraft is no longer in the realm of high risk development. The recently concluded Orbital Express (OE) mission included a fluid transfer demonstration that operated the hardware and control logic in space, bringing the Technology Readiness Level to a solid TRL 7 (demonstration of a system prototype in an operational environment). Orbital Express (funded by the Defense Advanced Research Projects Agency, DARPA) was launched aboard an Atlas-V rocket on March 9th, 2007. The mission had the objective of demonstrating technologies needed for routine servicing of spacecraft, namely autonomous rendezvous and docking, propellant resupply, and orbital replacement unit transfer. The demonstration system used two spacecraft. A servicing vehicle (ASTRO) performed multiple dockings with the client (NextSat) spacecraft, and performed a variety of propellant transfers in addition to exchanges of a battery and computer. The fluid transfer and propulsion system onboard ASTRO, in addition to providing the six degree-of-freedom (6 DOF) thruster system for rendezvous and docking, demonstrated autonomous transfer of monopropellant hydrazine to or from the NextSat spacecraft 15 times while on orbit. The fluid transfer system aboard the NextSat vehicle was designed to simulate a variety of client systems, including both blowdown pressurization and pressure regulated propulsion systems. The fluid transfer demonstrations started with a low level of autonomy, where ground controllers were allowed to review the status of the demonstration at numerous points before authorizing the next steps to be performed. The final transfers were performed at a full autonomy level where the ground authorized the start of a transfer sequence and then monitored data as the transfer proceeded. The major steps of a fluid transfer included the following: mate of the coupling, leak check of the coupling, venting of the coupling, priming of the coupling, fluid transfer, gauging

  1. Extending the lifespan and efficacies of immune cells used in adoptive transfer for cancer immunotherapies–A review

    PubMed Central

    Nayar, Sandeep; Dasgupta, Prokar; Galustian, Christine

    2015-01-01

    Cells used in adoptive cell-transfer immunotherapies against cancer include dendritic cells (DCs), natural-killer cells, and CD8+ T-cells. These cells may have limited efficacy due to their lifespan, activity, and immunosuppressive effects of tumor cells. Therefore, increasing longevity and activity of these cells may boost their efficacy. Four cytokines that can extend immune effector-cell longevity are IL-2, IL-7, IL-21, and IL-15. This review will discuss current knowledge on effector-cell lifespans and the mechanisms by which IL-2, IL-7, IL-15, and IL-21 can extend effector-cell longevity. We will also discuss how lifespan and efficacy of these cells can be regulated to allow optimal clinical benefits. PMID:26155387

  2. Lunox storage and transfer system

    NASA Technical Reports Server (NTRS)

    1987-01-01

    This semester, efforts were concentrated on the design of the Lunox transfer line from the storage area to the launch site. Emphasis was placed on flow and heat transfer problems and their remedies by reducing the effect of radiation by selecting materials for storage tanks, transfer lines and insulation. The design for the storage tank was based on a medium sized Lunox production facility of 6,000 metric tons per year and the frequency of transportation of Lunox from lunar launch site to lower lunar orbit of four launches per month. The design included the selection of materials for cryogenic storage, insulation and radiation shielding. Lunox was pumped to the storage area near the launch site through a piping network designed for maximum mass flow rate with a minimum boil off. The entire network incorporated specially designed radiation shields made of material which was lightweight and low in secondary radiation.

  3. Fate of gamma-interferon-activated killer blood monocytes adoptively transferred into the abdominal cavity of patients with peritoneal carcinomatosis

    SciTech Connect

    Stevenson, H.C.; Keenan, A.M.; Woodhouse, C.; Ottow, R.T.; Miller, P.; Steller, E.P.; Foon, K.A.; Abrams, P.G.; Beman, J.; Larson, S.M.

    1987-11-15

    Five patients with colorectal cancer widely metastatic to peritoneal surfaces have been treated i.p. with infusions of autologous blood monocytes made cytotoxic by in vitro incubation with human gamma-interferon. The monocytes were purified by a combination of cytapheresis and counter-current centrifugal elutriation procedures; each week approximately 350 million activated monocytes were given to patients as adoptive immunotherapy by a single i.p. instillation. On the eighth cycle of treatment the trafficking of i.p. infused blood monocytes was studied in two patients by prelabeling the cells with /sup 111/In. These activated cells became distributed widely within the peritoneal cavity. Two and 5 days after infusion their position within the peritoneum had not changed. When peritoneal specimens were obtained 36 h after /sup 111/In-labeled monocyte infusion, labeled monocytes were demonstrated to be associated with the serosal surfaces by autoradiographic analysis. Scintiscanning structures outside the abdominal cavity revealed that /sup 111/In-labeled monocytes infused i.p. did not traffic to other organs during the 5 days of the study. We conclude that i.p. adoptive transfer of autologous killer blood monocytes is an effective way of delivering these cytotoxic cells to sites of tumor burden on peritoneal surfaces in these cancer patients.

  4. Transfer potentials shape and equilibrate monetary systems

    NASA Astrophysics Data System (ADS)

    Fischer, Robert; Braun, Dieter

    2003-04-01

    We analyze a monetary system of random money transfer on the basis of double entry bookkeeping. Without boundary conditions, we do not reach a price equilibrium and violate text-book formulas of economist's quantity theory ( MV= PQ). To match the resulting quantity of money with the model assumption of a constant price, we have to impose boundary conditions. They either restrict specific transfers globally or impose transfers locally. Both connect through a general framework of transfer potentials. We show that either restricted or imposed transfers can shape Gaussian, tent-shape exponential, Boltzmann-exponential, pareto or periodic equilibrium distributions. We derive the master equation and find its general time-dependent approximate solution. An equivalent of quantity theory for random money transfer under the boundary conditions of transfer potentials is given.

  5. University Staff Perspectives on Change Management Strategies in Student Information System Adoption

    ERIC Educational Resources Information Center

    Tsang-Kosma, Winnie W.

    2010-01-01

    The process of information technology adoption and use is critical to deriving benefits of information technology. Thus, one of the most challenging issues in information systems research is to understand how people have experienced the adoption process that may lead to insights to why they accept or reject the information technology (Davis,…

  6. Secondary Teachers' Concerns in Adopting Learning Management Systems: A U.S. Perspective

    ERIC Educational Resources Information Center

    Lochner, Bianca; Conrad, Rita-Marie; Graham, Edward

    2015-01-01

    This study examined the concerns of U.S. secondary teachers regarding the adoption of learning management systems (LMSs) utilizing the concerns-based adoption model (CBAM). The stages of concern questionnaire used enabled the strength of teacher concerns to be measured for seven distinct stages of concerns: awareness, informational, personal,…

  7. Adopting Industry Standards for Control Systems Within Advanced Life Support

    NASA Technical Reports Server (NTRS)

    Young, James Scott; Boulanger, Richard

    2002-01-01

    This paper gives a description of OPC (Object Linking and Embedding for Process Control) standards for process control and outlines the experiences at JSC with using these standards to interface with I/O hardware from three independent vendors. The I/O hardware was integrated with a commercially available SCADA/HMI software package to make up the control and monitoring system for the Environmental Systems Test Stand (ESTS). OPC standards were utilized for communicating with I/O hardware and the software was used for implementing monitoring, PC-based distributed control, and redundant data storage over an Ethernet physical layer using an embedded din-rail mounted PC.

  8. Modeling the School System Adoption Process for Library Networking.

    ERIC Educational Resources Information Center

    Kester, Diane Katherine Davies

    The successful inclusion of school library media centers in fully articulated networks involves considerable planning and organization for technological change. In this study a preliminary model of the stages of school system participation in library networks was developed with the major activities for each stage identified. The model follows…

  9. Saturn facility oil transfer automation system

    SciTech Connect

    Joseph, Nathan R.; Thomas, Rayburn Dean; Lewis, Barbara Ann; Malagon, Hector M.

    2014-02-01

    The Saturn accelerator, owned by Sandia National Laboratories, has been in operation since the early 1980s and still has many of the original systems. A critical legacy system is the oil transfer system which transfers 250,000 gallons of transformer oil from outside storage tanks to the Saturn facility. The oil transfer system was iden- ti ed for upgrade to current technology standards. Using the existing valves, pumps, and relay controls, the system was automated using the National Instruments cRIO FGPA platform. Engineered safety practices, including a failure mode e ects analysis, were used to develop error handling requirements. The uniqueness of the Saturn Oil Automated Transfer System (SOATS) is in the graphical user interface. The SOATS uses an HTML interface to communicate to the cRIO, creating a platform independent control system. The SOATS was commissioned in April 2013.

  10. Deletion of Plasmodium berghei-Specific CD4+ T Cells Adoptively Transferred into Recipient Mice after Challenge with Homologous Parasite

    NASA Astrophysics Data System (ADS)

    Hirunpetcharat, Chakrit; Good, Michael F.

    1998-02-01

    The immune response to malaria parasites includes T cell responses that reduce parasites by effector T cell responses and by providing help for antibody responses. Some parasites are more sensitive to antibody and others are more sensitive to cell-mediated immunity. We demonstrate that cultured CD4+ T cells that produce interferon CD4+ and interleukin 2, but not interleukin 4, in response to stimulation with the rodent parasite Plasmodium berghei can reduce but not eliminate parasites in vivo after adoptive transfer. Although cells can persist in vivo for up to 9 months in uninfected mice, infection results in elimination of up to 99% of specific T cells in different tissues, as judged by tracking T cells labeled with the fluorescent dye 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester. T cells specific for ovalbumin are unaffected. In vivo activation and division of transferred T cells per se are not responsible for deletion because T cells positive for 5-(and -6)-carboxyfluorescein diacetate succinimidyl ester divide up to six times within 7 days in uninfected mice and are not deleted. Understanding the factors responsible for parasite-mediated specific deletion of T cells would enhance our knowledge of parasite immunity.

  11. Personal health systems - Opportunities and barriers for adoption.

    PubMed

    Korhonen, Ilkka; Mattila, Elina M; Vam Gils, Mark

    2010-01-01

    INCREASING prevalence of lifestyle-related health risks and chronic diseases, coupled with limited resources in the healthcare system, calls for citizen-centric health promotion and disease prevention measures as well as new care models for management of chronic diseases. As a future scenario emphasis of the health care should gradually shift from treating and managing of diseases to their prevention and early interventions. The risk of chronic diseases begins to rise and physical capacity begins to decline after the age of 30. Therefore, working-age citizens are an important target group for health promotion and early interventions. PMID:21096056

  12. [How to carry out work on family planning after adopting production responsibility systems in rural areas].

    PubMed

    Xiao, S H

    1982-05-29

    After the Third Meeting of the Eleventh People's Congress, the entire responsibility for agricultural production was transferred to a lower level. Peasants in various areas have adopted the so called production responsibility system, and the phenomenon of an increased population rate has also appeared in some areas. In this article, the author discusses how to solve these problems created by the new situation. The 1st step is try to control population growth through socialist propaganda education, administrative measures, economic incentives and punishments, and family planning work. The 2nd step is to popularize the practice of having only 1 child per household in the rural areas. The 2nd and 3rd child in each family should be controlled and prohibited. This policy formulated by the Central Government should be carried out thoroughly. Families which follow the policy and have only 1 child should be encouraged with economic rewards, and those families which have 2 or more children should be punished economically. The 3rd step is to establish a national work team to be in charge of family planning and birth control. There should be an ideological unity among the nation's leadership. Party members and cadres should establish themselves as good examples for the people so that the population control work may become successful. PMID:12266135

  13. Optical Energy Transfer and Conversion System

    NASA Technical Reports Server (NTRS)

    Stone, William C. (Inventor); Hogan, Bartholomew P. (Inventor)

    2015-01-01

    An optical power transfer system comprising a fiber spooler, a fiber optic rotary joint mechanically connected to the fiber spooler, and an electrical power extraction subsystem connected to the fiber optic rotary joint with an optical waveguide. Optical energy is generated at and transferred from a base station through fiber wrapped around the spooler, through the rotary joint, and ultimately to the power extraction system at a remote mobility platform for conversion to another form of energy.

  14. Electric power distribution and load transfer system

    NASA Technical Reports Server (NTRS)

    Bradford, Michael P. (Inventor); Parkinson, Gerald W. (Inventor); Grant, Ross M. (Inventor)

    1989-01-01

    A power distribution system includes a plurality of power sources and load transfer units including transistors and diodes connected in series and leading to a common power output, each of the transistors being controller switchable subject to voltage levels of the respective input and output sides of said transistors, and the voltage and current level of said common power output. The system is part of an interconnection scheme in which all but one of the power sources is connected to a single load transfer unit, enabling the survival of at least a single power source with the failure of one of the load transfer units.

  15. Adoption and utilization of electronic health record systems by long-term care facilities in Texas.

    PubMed

    Wang, Tiankai; Biedermann, Sue

    2012-01-01

    Long-term care (LTC) is an important sector in the healthcare industry; however, the adoption of electronic health record (EHR) systems in LTC facilities lags behind that in other sectors of healthcare. This study examines the adoption and utilization of EHRs in LTC facilities in Texas and identifies the barriers preventing implementation of EHRs. A survey instrument was mailed to all Texas LTC facilities between October 2010 and March 2011. The survey found that in Texas, 39.5 percent of LTC facilities have fully or partially implemented EHR systems and 15 percent of LTC facilities have no plans to adopt EHRs yet. There is significant variation in the use of EHR functionalities across the LTC facilities in Texas. In the LTC facilities, the administrative functions of EHRs have been more widely adopted and are more widely utilized than the clinical functions of EHRs. Among the clinical functions adopted, the resident assessment, physician orders, care management plan, and census management are the leading functions used by the LTC facilities in Texas. Lack of capital resources is still the greatest barrier to EHR adoption and implementation. Policy makers, vendors, LTC administrators, educators, and researchers should make more effort to improve EHR adoption in LTC facilities. PMID:22737099

  16. Combined IL-15 and IL-12 drives the generation of CD34+-derived natural killer cells with superior maturation and alloreactivity potential following adoptive transfer

    PubMed Central

    Cany, Jeannette; van der Waart, Anniek B; Spanholtz, Jan; Tordoir, Marleen; Jansen, Joop H; van der Voort, Robbert; Schaap, Nicolaas M; Dolstra, Harry

    2015-01-01

    Adoptive transfer of allogeneic natural killer (NK) cells represents a promising treatment approach against cancer, including acute myeloid leukemia (AML). Previously, we reported a cytokine-based culture method for the generation of NK cell products with high cell number and purity. In this system, CD34+ hematopoietic progenitor cells (HPC) were expanded and differentiated into NK cells under stroma-free conditions in the presence of IL-15 and IL-2. We show that combining IL-15 with IL-12 drives the generation of more mature and highly functional NK cells. In particular, replacement of IL-2 by IL-12 enhanced the cytolytic activity and IFNγ production of HPC-NK cells toward cultured and primary AML cells in vitro, and improved antileukemic responses in NOD/SCID-IL2Rγnull (NSG) mice bearing human AML cells. Phenotypically, IL-12 increased the frequency of HPC-NK cells expressing NKG2A and killer immunoglobulin-like receptor (KIR), which were more responsive to target cell stimulation. In addition, NK15/12 cell products demonstrated superior maturation potential, resulting in >70% positivity for CD16 and/or KIR within 2 weeks after infusion into NSG mice. We predict that higher functionality and faster in vivo maturation will favor HPC-NK cell alloreactivity toward malignant cells in patients, making this cytokine combination an attractive strategy to generate clinical HPC-NK cell products for cancer adoptive immunotherapy. PMID:26140247

  17. Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

    PubMed Central

    Steinbach, Erin C.; Gipson, Gregory R.; Sheikh, Shehzad Z.

    2015-01-01

    There are many different animal models available for studying the pathogenesis of human inflammatory bowel diseases (IBD), each with its own advantages and disadvantages. We describe here an experimental colitis model that is initiated by adoptive transfer of syngeneic splenic CD4+CD45RBhigh T cells into T and B cell deficient recipient mice. The CD4+CD45RBhigh T cell population that largely consists of naïve effector cells is capable of inducing chronic intestinal inflammation, closely resembling key aspects of human IBD. This method can be manipulated to study aspects of disease onset and progression. Additionally it can be used to study the function of innate, adaptive, and regulatory immune cell populations, and the role of environmental exposures, i.e., the microbiota, in intestinal inflammation. In this article we illustrate the methodology for inducing colitis with a step-by-step protocol. This includes a video demonstration of key technical aspects required to successfully develop this murine model of experimental colitis for research purposes. PMID:25938395

  18. MELOE-1 is a new antigen overexpressed in melanomas and involved in adoptive T cell transfer efficiency

    PubMed Central

    Godet, Yann; Moreau-Aubry, Agnès; Guilloux, Yannik; Vignard, Virginie; Khammari, Amir; Dreno, Brigitte; Jotereau, Francine; Labarriere, Nathalie

    2008-01-01

    A cytotoxic T lymphocyte (CTL) clone was derived from a tumor-infiltrating lymphocyte (TIL) population infused to a melanoma patient who remained relapse free for 10 yr after this adoptive transfer. This clone recognized all melanoma cell lines tested and, to a lower extent, melanocytes, in the context of human histocompatibility leukocyte antigen A2 (HLA-A2), but it did not recognize other tumor cell types. The gene coding for the antigen recognized by this clone was identified by the screening of a melanoma complementary DNA expression library. This antigen is overexpressed in melanomas, compared with other cancer cell lines and healthy tissues, and was thus called melanoma-overexpressed antigen (meloe). Remarkably, the structure of meloe was unusual, with multiple short open reading frames (ORFs). The peptide recognized by the CTL clone was encoded by one of these ORFs, called MELOE-1. Using a specific HLA-A2/peptide tetramer, we showed a correlation between the infusion of TILs containing MELOE-1–specific T cells and relapse prevention in HLA-A2 patients. Indeed, 5 out of 9 patients who did not relapse were infused with TILs that contained MELOE-1–specific T cells, whereas 0 out of the 21 patients who relapsed was infused with such TIL-containing lymphocytes. Overall, our results suggest that this new antigen is involved in immunosurveillance and, thus, represents an attractive target for immunotherapy protocols of melanoma. PMID:18936238

  19. Modulation of tumor response to photodynamic therapy in severe combined immunodeficient (SCID) mice by adoptively transferred lymphoid cells

    NASA Astrophysics Data System (ADS)

    Korbelik, Mladen; Krosl, Gorazd; Krosl, Jana; Dougherty, Graeme J.

    1996-04-01

    Photodynamic treatment, consisting of intravenous injection of PhotofrinR (10 mg/kg) followed by exposure to 110 J/cm2 of 630 plus or minus 10 nm light 24 hours later, cured 100% of EMT6 tumors (murine mammary sarcoma) growing in syngeneic immunocompetent BALB/C mice. In contrast, the same treatment produced no cures of EMT6 tumors growing in either nude or SCID mice (immunodeficient strains). EMT6 tumors growing in BALB/C and SCID mice showed no difference in either the level of PhotofrinR accumulated per gram of tumor tissue, or the extent of tumor cell killing during the first 24 hours post photodynamic therapy (PDT). In an attempt to improve the sensitivity to PDT of EMT6 tumors growing in SCID mice, these hosts were given either splenic T lymphocytes or whole bone marrow from BALB/C mice. The adoptive transfer of lymphocytes 9 days before PDT was successful in delaying tumor recurrence but produced no cures. A better improvement in PDT response was obtained with tumors growing in SCID mice reconstituted with BALB/C bone marrow (tumor cure rate of 63%). The results of this study demonstrate that, at least with the EMT6 tumor model, antitumor immune activity mediated by lymphoid cell populations makes an important contribution to the curative effect of PDT.

  20. Open Online System Adoption in K-12 as a Democratising Factor

    ERIC Educational Resources Information Center

    Kimmons, Royce

    2015-01-01

    This study seeks to understand how district size and wealth factors influence the adoption of open-source online systems in primary and secondary (K-12) education. Most schools now utilise online systems (e.g. CMS, LMS, SIS) for a number of purposes, and it is anticipated that no-cost and open-source systems could be of great value for…

  1. Intestinal Barrier Dysfunction Develops at the Onset of Experimental Autoimmune Encephalomyelitis, and Can Be Induced by Adoptive Transfer of Auto-Reactive T Cells

    PubMed Central

    Nouri, Mehrnaz; Bredberg, Anders; Weström, Björn; Lavasani, Shahram

    2014-01-01

    Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system with a pathogenesis involving a dysfunctional blood-brain barrier and myelin-specific, autoreactive T cells. Although the commensal microbiota seems to affect its pathogenesis, regulation of the interactions between luminal antigens and mucosal immune elements remains unclear. Herein, we investigated whether the intestinal mucosal barrier is also targeted in this disease. Experimental autoimmune encephalomyelitis (EAE), the prototypic animal model of MS, was induced either by active immunization or by adoptive transfer of autoreactive T cells isolated from these mice. We show increased intestinal permeability, overexpression of the tight junction protein zonulin and alterations in intestinal morphology (increased crypt depth and thickness of the submucosa and muscularis layers). These intestinal manifestations were seen at 7 days (i.e., preceding the onset of neurological symptoms) and at 14 days (i.e., at the stage of paralysis) after immunization. We also demonstrate an increased infiltration of proinflammatory Th1/Th17 cells and a reduced regulatory T cell number in the gut lamina propria, Peyer's patches and mesenteric lymph nodes. Adoptive transfer to healthy mice of encephalitogenic T cells, isolated from EAE-diseased animals, led to intestinal changes similar to those resulting from the immunization procedure. Our findings show that disruption of intestinal homeostasis is an early and immune-mediated event in EAE. We propose that this intestinal dysfunction may act to support disease progression, and thus represent a potential therapeutic target in MS. In particular, an increased understanding of the regulation of tight junctions at the blood-brain barrier and in the intestinal wall may be crucial for design of future innovative therapies. PMID:25184418

  2. Design Criteria for Bagless Transfer System (BTS) Packaging System

    SciTech Connect

    RISENMAY, H.R.

    2000-04-26

    This document provides the criteria for the design and installation of a Bagless Transfer System (BTS); Blend, Sieve and Balance Equipment; and Supercritical Fluid Extraction System (SFE). The project consists of 3 major modules: (1) Bagless Transfer System (BTS) Module; (2) Blend, Sieve and Balance Equipment; and (3) Supercritical Fluid Extraction (SFE) Module.

  3. Transfer Function Control for Biometric Monitoring System

    NASA Technical Reports Server (NTRS)

    Chmiel, Alan J. (Inventor); Humphreys, Bradley T. (Inventor); Grodinsky, Carlos M. (Inventor)

    2015-01-01

    A modular apparatus for acquiring biometric data may include circuitry operative to receive an input signal indicative of a biometric condition, the circuitry being configured to process the input signal according to a transfer function thereof and to provide a corresponding processed input signal. A controller is configured to provide at least one control signal to the circuitry to programmatically modify the transfer function of the modular system to facilitate acquisition of the biometric data.

  4. Adoption of technology, management practices, and production systems in US milk production.

    PubMed

    Khanal, A R; Gillespie, J; MacDonald, J

    2010-12-01

    The introduction of new technology, management practices, and alternative production systems has resulted in rapid structural change in the US dairy industry. This paper examines adoption rates and adopter characteristics for the following dairy technologies, practices, and systems: holding pen with an udder washer, milking units with automatic take-offs, genetic selection technologies, recombinant bovine somatotropin, membership in the Dairy Herd Improvement Association, computerized feed delivery systems, computerized milking systems, use of a nutritionist to design feed rations, grazing, milking cows 3 times daily, and milking parlors. Four of these were used on a greater percentage of farms in 2005 than in 2000, but increased farm sizes and the interaction of farm size with adoption suggest a greater percentage of milk being produced under each, with the exception of grazing. Except for grazing, technologies were generally complementary. PMID:21094776

  5. Wavelet excited measurement of system transfer function.

    PubMed

    Olkkonen, H; Olkkonen, J T

    2007-02-01

    This article introduces a new method, which is referred to as the wavelet excitation method (WEM), for the measurement of the system transfer function. Instead of commonly used impulse or sine wave excitations, the method uses a sequential excitation by biorthogonal symmetric wavelets. The system transfer function is reconstructed from the output measurements. In the WEM the signals can be designed so that if N different excitation sequences are used and the excitation rate is f, the sampling rate of the analog-to-digital converter can be reduced to f/N. The WEM is especially advantageous in testing systems, where high quality impulse excitation cannot be applied. The WEM gave consistent results in transfer function measurements of various multistage amplifiers with the linear circuit analysis (SPICE) and the sine wave excitation methods. The WEM makes available new high speed sensor applications, where the sampling rate of the sensor may be considerably lower compared with the system bandwidth. PMID:17578145

  6. External factors in hospital information system (HIS) adoption model: a case on Malaysia.

    PubMed

    Lee, Heng Wei; Ramayah, Thurasamy; Zakaria, Nasriah

    2012-08-01

    Studies related to healthcare ICT integration in Malaysia are relatively little, thus this paper provide a literature review of the integration of information and communication technologies (ICT) in the healthcare sector in Malaysia through the hospital information system (HIS). Our study emphasized on secondary data to investigate the factors related to ICT integration in healthcare through HIS. Therefore this paper aimed to gather an in depth understanding of issues related to HIS adoption, and contributing in fostering HIS adoption in Malaysia and other countries. This paper provides a direction for future research to study the correlation of factors affecting HIS adoption. Finally a research model is proposed using current adoption theories and external factors from human, technology, and organization perspectives. PMID:21384267

  7. Estimating The Rate of Technology Adoption for Cockpit Weather Information Systems

    NASA Technical Reports Server (NTRS)

    Kauffmann, Paul; Stough, H. P.

    2000-01-01

    In February 1997, President Clinton announced a national goal to reduce the weather related fatal accident rate for aviation by 80% in ten years. To support that goal, NASA established an Aviation Weather Information Distribution and Presentation Project to develop technologies that will provide timely and intuitive information to pilots, dispatchers, and air traffic controllers. This information should enable the detection and avoidance of atmospheric hazards and support an improvement in the fatal accident rate related to weather. A critical issue in the success of NASA's weather information program is the rate at which the market place will adopt this new weather information technology. This paper examines that question by developing estimated adoption curves for weather information systems in five critical aviation segments: commercial, commuter, business, general aviation, and rotorcraft. The paper begins with development of general product descriptions. Using this data, key adopters are surveyed and estimates of adoption rates are obtained. These estimates are regressed to develop adoption curves and equations for weather related information systems. The paper demonstrates the use of adoption rate curves in product development and research planning to improve managerial decision processes and resource allocation.

  8. Accountability of the BC Transfer System

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2005

    2005-01-01

    The purpose of the paper is to provide evidence that the Transfer System in British Columbia (BC) has been effective and therefore accountable for the public funding that supports that system. The paper attempts to show: (1) the multi-faceted nature, breadth and depth of research that has been conducted to determine the effectiveness of the BC…

  9. Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms.

    PubMed

    Yu, Yu; Cho, Hyun-Ii; Wang, Dapeng; Kaosaard, Kane; Anasetti, Claudio; Celis, Esteban; Yu, Xue-Zhong

    2013-02-15

    Adoptive cell transfer (ACT) of ex vivo-activated autologous tumor-reactive T cells is currently one of the most promising approaches for cancer immunotherapy. Recent studies provided some evidence that IL-17-producing CD8(+) (Tc17) cells may exhibit potent antitumor activity, but the specific mechanisms have not been completely defined. In this study, we used a murine melanoma lung-metastasis model and tested the therapeutic effects of gp100-specific polarized type I CD8(+) cytotoxic T (Tc1) or Tc17 cells combined with autologous bone marrow transplantation after total body irradiation. Bone marrow transplantation combined with ACT of antitumor (gp100-specific) Tc17 cells significantly suppressed the growth of established melanoma, whereas Tc1 cells induced long-term tumor regression. After ACT, Tc1 cells maintained their phenotype to produce IFN-γ, but not IL-17. However, although Tc17 cells largely preserved their ability to produce IL-17, a subset secreted IFN-γ or both IFN-γ and IL-17, indicating the plasticity of Tc17 cells in vivo. Furthermore, after ACT, the Tc17 cells had a long-lived effector T cell phenotype (CD127(hi)/KLRG-1(low)) as compared with Tc1 cells. Mechanistically, Tc1 cells mediated antitumor immunity primarily through the direct effect of IFN-γ on tumor cells. In contrast, despite the fact that some Tc17 cells also secreted IFN-γ, Tc17-mediated antitumor immunity was independent of the direct effects of IFN-γ on the tumor. Nevertheless, IFN-γ played a critical role by creating a microenvironment that promoted Tc17-mediated antitumor activity. Taken together, these studies demonstrate that both Tc1 and Tc17 cells can mediate effective antitumor immunity through distinct effector mechanisms, but Tc1 cells are superior to Tc17 cells in mediating tumor regression. PMID:23315072

  10. High vitamin D3 diet administered during active colitis negatively affects bone metabolism in an adoptive T cell transfer model

    PubMed Central

    Larmonier, C. B.; McFadden, R.-M. T.; Hill, F. M.; Schreiner, R.; Ramalingam, R.; Besselsen, D. G.; Ghishan, F. K.

    2013-01-01

    Decreased bone mineral density (BMD) represents an extraintestinal complication of inflammatory bowel disease (IBD). Vitamin D3 has been considered a viable adjunctive therapy in IBD. However, vitamin D3 plays a pleiotropic role in bone modeling and regulates the bone formation-resorption balance, depending on the physiological environment, and supplementation during active IBD may have unintended consequences. We evaluated the effects of vitamin D3 supplementation during the active phase of disease on colonic inflammation, BMD, and bone metabolism in an adoptive IL-10−/− CD4+ T cell transfer model of chronic colitis. High-dose vitamin D3 supplementation for 12 days during established disease had negligible effects on mucosal inflammation. Plasma vitamin D3 metabolites correlated with diet, but not disease, status. Colitis significantly reduced BMD. High-dose vitamin D3 supplementation did not affect cortical bone but led to a further deterioration of trabecular bone morphology. In mice fed a high vitamin D3 diet, colitis more severely impacted bone formation markers (osteocalcin and bone alkaline phosphatase) and increased bone resorption markers, ratio of receptor activator of NF-κB ligand to osteoprotegrin transcript, plasma osteoprotegrin level, and the osteoclast activation marker tartrate-resistant acid phosphatase (ACp5). Bone vitamin D receptor expression was increased in mice with chronic colitis, especially in the high vitamin D3 group. Our data suggest that vitamin D3, at a dose that does not improve inflammation, has no beneficial effects on bone metabolism and density during active colitis or may adversely affect BMD and bone turnover. These observations should be taken into consideration in the planning of further clinical studies with high-dose vitamin D3 supplementation in patients with active IBD. PMID:23639807

  11. Technology transfer potential of an automated water monitoring system. [market research

    NASA Technical Reports Server (NTRS)

    Jamieson, W. M.; Hillman, M. E. D.; Eischen, M. A.; Stilwell, J. M.

    1976-01-01

    The nature and characteristics of the potential economic need (markets) for a highly integrated water quality monitoring system were investigated. The technological, institutional and marketing factors that would influence the transfer and adoption of an automated system were studied for application to public and private water supply, public and private wastewater treatment and environmental monitoring of rivers and lakes.

  12. Critical Factors Influencing Decision to Adopt Human Resource Information System (HRIS) in Hospitals

    PubMed Central

    Alam, Md Golam Rabiul; Masum, Abdul Kadar Muhammad; Beh, Loo-See; Hong, Choong Seon

    2016-01-01

    The aim of this research is to explore factors influencing the management decisions to adopt human resource information system (HRIS) in the hospital industry of Bangladesh—an emerging developing country. To understand this issue, this paper integrates two prominent adoption theories—Human-Organization-Technology fit (HOT-fit) model and Technology-Organization-Environment (TOE) framework. Thirteen factors under four dimensions were investigated to explore their influence on HRIS adoption decisions in hospitals. Employing non-probability sampling method, a total of 550 copies of structured questionnaires were distributed among HR executives of 92 private hospitals in Bangladesh. Among the respondents, usable questionnaires were 383 that suggesting a valid response rate of 69.63%. We classify the sample into 3 core groups based on the HRIS initial implementation, namely adopters, prospectors, and laggards. The obtained results specify 5 most critical factors i.e. IT infrastructure, top management support, IT capabilities of staff, perceived cost, and competitive pressure. Moreover, the most significant dimension is technological dimension followed by organisational, human, and environmental among the proposed 4 dimensions. Lastly, the study found existence of significant differences in all factors across different adopting groups. The study results also expose constructive proposals to researchers, hospitals, and the government to enhance the likelihood of adopting HRIS. The present study has important implications in understanding HRIS implementation in developing countries. PMID:27494334

  13. Critical Factors Influencing Decision to Adopt Human Resource Information System (HRIS) in Hospitals.

    PubMed

    Alam, Md Golam Rabiul; Masum, Abdul Kadar Muhammad; Beh, Loo-See; Hong, Choong Seon

    2016-01-01

    The aim of this research is to explore factors influencing the management decisions to adopt human resource information system (HRIS) in the hospital industry of Bangladesh-an emerging developing country. To understand this issue, this paper integrates two prominent adoption theories-Human-Organization-Technology fit (HOT-fit) model and Technology-Organization-Environment (TOE) framework. Thirteen factors under four dimensions were investigated to explore their influence on HRIS adoption decisions in hospitals. Employing non-probability sampling method, a total of 550 copies of structured questionnaires were distributed among HR executives of 92 private hospitals in Bangladesh. Among the respondents, usable questionnaires were 383 that suggesting a valid response rate of 69.63%. We classify the sample into 3 core groups based on the HRIS initial implementation, namely adopters, prospectors, and laggards. The obtained results specify 5 most critical factors i.e. IT infrastructure, top management support, IT capabilities of staff, perceived cost, and competitive pressure. Moreover, the most significant dimension is technological dimension followed by organisational, human, and environmental among the proposed 4 dimensions. Lastly, the study found existence of significant differences in all factors across different adopting groups. The study results also expose constructive proposals to researchers, hospitals, and the government to enhance the likelihood of adopting HRIS. The present study has important implications in understanding HRIS implementation in developing countries. PMID:27494334

  14. Level of Adoption of Quality Management Systems Into the Mexican Pork Industry

    NASA Astrophysics Data System (ADS)

    Maldonado-Siman, Em; Ruíz-Flores, Agustín; Núñez-Domínguez, Rafael; González-Alcorta, Mariano; Hernández-Rodríguez, Bertha Alicia

    This research studies the characteristics of the Mexican pork sector; adoption status of quality management systems, and product destinations. Ninety six percent of fifty enterprises have fully answered a questionnaire. Ninety percent are small and medium-sized, the rest are large-sized firms. Nineteen percent of them have totally adopted HACCP, sixty three percent are implementing or planning to do it, the rest have no plans to adopt it. Thirteen percent of the enterprises had ISO 9000. Thirty four percent of their sales go to supermarkets, 57% to other retail chains and 9% to exportation. Product destinations are mainly Central America, United States of America, Asia and Mexico. To improve efficiency and the quality of process it is necessary to implement HACCP. Besides, customers and legal requirements are the external factors, which result in this adoption. In the process of implementing, there are some problems, such as staff motivation and training. The results suggest that HACCP system operating is important for the Mexican pork industry. It also has relevant implications in domestic trade. It is necessary to encourage adoption of quality management systems in the sector.

  15. Exploring the business case for ambulatory electronic health record system adoption.

    PubMed

    Song, Paula H; McAlearney, Ann Scheck; Robbins, Julie; McCullough, Jeffrey S

    2011-01-01

    Widespread implementation and use of electronic health record (EHR) systems has been recognized by healthcare leaders as a cornerstone strategy for systematically reducing medical errors and improving clinical quality. However, EHR adoption requires a significant capital investment for healthcare providers, and cost is often cited as a barrier. Despite the capital requirements, a true business case for EHR system adoption and implementation has not been made. This is of concern, as the lack of a business case can influence decision making about EHR investments. The purpose of this study was to examine the role of business case analysis in healthcare organizations' decisions to invest in ambulatory EHR systems, and to identify what factors organizations considered when justifying an ambulatory EHR. Using a qualitative case study approach, we explored how five organizations that are considered to have best practices in ambulatory EHR system implementation had evaluated the business case for EHR adoption. We found that although the rigor of formal business case analysis was highly variable, informants across these organizations consistently reported perceiving that a positive business case for EHR system adoption existed, especially when they considered both financial and non-financial benefits. While many consider EHR system adoption inevitable in healthcare, this viewpoint should not deter managers from conducting a business case analysis. Results of such an analysis can inform healthcare organizations' understanding about resource allocation needs, help clarify expectations about financial and clinical performance metrics to be monitored through EHR systems, and form the basis for ongoing organizational support to ensure successful system implementation. PMID:21714372

  16. Transfer Patterns of Students, University of Hawaii System, Fall 1975.

    ERIC Educational Resources Information Center

    Hawaii Univ., Honolulu. Management Systems Office.

    In fall 1975, 4,702 students transferred into the University of Hawaii (UH) System, representing a 15.5 percent increase over the number of transfers in 1974. Of the total, 56 percent transferred from within the UH System, 6 percent transferred from other Hawaii institutions, and 36 percent transferred from out-of-state institutions. The total…

  17. System Transfer, Education, and Development in Mozambique

    ERIC Educational Resources Information Center

    Cossa, Jose

    2011-01-01

    In this study the author used conceptual historical method to assess the phenomenon of system transfer and the association between education and development in Mozambique. The assessment was administered through critical analysis of documents pertaining to the Salazar (1924-1966), Machel (1975-1986), and Chissano (1986-2005) administrations. The…

  18. Information transfer in the National Airspace System

    NASA Technical Reports Server (NTRS)

    Lee, Alfred T.

    1988-01-01

    An informal overview is given of the work in progress and the planned work in the area of information transfer that specifically addresses human factors issues in National Airspace System (NAS). The issues of how weather information will be displayed on the flight deck, the development of appropriate decision making technology, and digital datalink transmission are also briefly discussed.

  19. Promoting Transfer by Grounding Complex Systems Principles

    ERIC Educational Resources Information Center

    Goldstone, Robert L.; Wilensky, Uri

    2008-01-01

    Understanding scientific phenomena in terms of complex systems principles is both scientifically and pedagogically important. Situations from different disciplines of science are often governed by the same principle, and so promoting knowledge transfer across disciplines makes valuable cross-fertilization and scientific unification possible.…

  20. Diffusion of Innovation: A Case Study of Course Management System Adoption

    ERIC Educational Resources Information Center

    Powell, Phillip, Ed.D.

    2008-01-01

    The purpose of this study was to examine the processes of evaluation, selection, adoption and diffusion of a course management system (CMS). This study incorporated a cross-case analysis using a multiple case study approach, which included two institutions, each having six participants. The participants were placed into three categories: faculty,…

  1. A Social System Analysis of Beautification Project Adoption in Two Wisconsin Cities.

    ERIC Educational Resources Information Center

    Apps, Darrel Arvin

    A study was made to identify factors which contribute to community interest in, and adoption of, beautification projects and to identify personal and social characteristics of participants, related to a broad interpretation of beautification. A social system analysis approach was used as the framework of the study. Two Wisconsin cities' social…

  2. Factors Predicting Oncology Care Providers' Behavioral Intention to Adopt Clinical Decision Support Systems

    ERIC Educational Resources Information Center

    Wolfenden, Andrew

    2012-01-01

    The purpose of this quantitative correlation study was to examine the predictors of user behavioral intention on the decision of oncology care providers to adopt or reject the clinical decision support system. The Unified Theory of Acceptance and Use of Technology (UTAUT) formed the foundation of the research model and survey instrument. The…

  3. Factors Related to Faculty Members' Attitude and Adoption of a Learning Management System

    ERIC Educational Resources Information Center

    Wichadee, Saovapa

    2015-01-01

    Learning Management Systems (LMS) play a crucial role in organizing the course contents. However, some instructors use LMS in their classes while some do not. This study aimed to discover the factors in relation to the instructors' attitude toward LMS and adoption of LMS in their course. A survey was administered to 62 instructors to follow up the…

  4. Acquisition systems for heat transfer measurement

    SciTech Connect

    De Witt, R.J.

    1983-01-01

    Practical heat transfer data acquisition systems are normally characterized by the need for high-resolution, low-drift, low-speed recording devices. Analog devices such as strip chart or circular recorders and FM analog magnetic tape have excellent resolution and work well when data will be presented in temperature versus time format only and need not be processed further. Digital systems are more complex and require an understanding of the following components: digitizing devices, interface bus types, processor requirements, and software design. This paper discusses all the above components of analog and digital data acquisition, as they are used in current practice. Additional information on thermocouple system analysis will aid the user in developing accurate heat transfer measuring systems.

  5. Satellite system considerations for computer data transfer

    NASA Technical Reports Server (NTRS)

    Cook, W. L.; Kaul, A. K.

    1975-01-01

    Communications satellites will play a key role in the transmission of computer generated data through nationwide networks. This paper examines critical aspects of satellite system design as they relate to the computer data transfer task. In addition, it discusses the factors influencing the choice of error control technique, modulation scheme, multiple-access mode, and satellite beam configuration based on an evaluation of system requirements for a broad range of application areas including telemetry, terminal dialog, and bulk data transmission.

  6. CLASSIFICATION OF THE MGR CANISTER TRANSFER SYSTEM

    SciTech Connect

    S.E. Salzman

    1999-08-30

    The purpose of this analysis is to document the Quality Assurance (QA) classification of the Monitored Geologic Repository (MGR) canister transfer system structures, systems and components (SSCs) performed by the MGR Safety Assurance Department. This analysis also provides the basis for revision of YMP/90-55Q, Q-List (YMP 1998). The Q-List identifies those MGR SSCs subject to the requirements of DOE/RW-0333P, ''Quality Assurance Requirements and Description'' (QARD) (DOE 1998).

  7. Classification of the MGR Assembly Transfer System

    SciTech Connect

    S.E. Salzman

    1999-08-31

    The purpose of this analysis is to document the Quality Assurance (QA) classification of the Monitored Geologic Repository (MGR) assembly transfer system structures, systems and components (SSCs) performed by the MGR Safety Assurance Department. This analysis also provides the basis for revision of YMP/90-55Q, Q-List (YMP 1998). The Q-List identifies those MGR SSCs subject to the requirements of DOE/RW-0333P, ''Quality Assurance Requirements and Description'' (QARD) (DOE 1998).

  8. Understanding managerial behaviour during initial steps of a clinical information system adoption

    PubMed Central

    2011-01-01

    Background While the study of the information technology (IT) implementation process and its outcomes has received considerable attention, the examination of pre-adoption and pre-implementation stages of configurable IT uptake appear largely under-investigated. This paper explores managerial behaviour during the periods prior the effective implementation of a clinical information system (CIS) by two Canadian university multi-hospital centers. Methods Adopting a structurationist theoretical stance and a case study research design, the processes by which CIS managers' patterns of discourse contribute to the configuration of the new technology in their respective organizational contexts were longitudinally examined over 33 months. Results Although managers seemed to be aware of the risks and organizational impact of the adoption of a new clinical information system, their decisions and actions over the periods examined appeared rather to be driven by financial constraints and power struggles between different groups involved in the process. Furthermore, they largely emphasized technological aspects of the implementation, with organizational dimensions being put aside. In view of these results, the notion of 'rhetorical ambivalence' is proposed. Results are further discussed in relation to the significance of initial decisions and actions for the subsequent implementation phases of the technology being configured. Conclusions Theoretical and empirically grounded, the paper contributes to the underdeveloped body of literature on information system pre-implementation processes by revealing the crucial role played by managers during the initial phases of a CIS adoption. PMID:21682885

  9. Forest Resource Information System. Phase 3: System transfer report

    NASA Technical Reports Server (NTRS)

    Mroczynski, R. P. (Principal Investigator)

    1981-01-01

    Transfer of the forest reserve information system (FRIS) from the Laboratory for Applications of Remote Sensing to St. Regis Paper Company is described. Modifications required for the transfer of the LARYS image processing software are discussed. The reformatting, geometric correction, image registration, and documentation performed for preprocessing transfer are described. Data turnaround was improved and geometrically corrected and ground-registered CCT LANDSAT 3 data provided to the user. The technology transfer activities are summarized. An application test performed in order to assess a Florida land acquisition is described. A benefit/cost analysis of FRIS is presented.

  10. miR-23a blockade enhances adoptive T cell transfer therapy by preserving immune-competence in the tumor microenvironment

    PubMed Central

    Lin, Regina; Sampson, John H; Li, Qi-Jing; Zhu, Bo

    2015-01-01

    In adoptive T cell transfer therapy (ACT), the antitumor efficacy of cytotoxic CD8+ T lymphocytes (CTLs) has been limited by tumor-induced immunosuppression. We have demonstrated that miR-23a blockade in tumor-specific CTLs conferred resilience to TGFβ-mediated immunosuppression, resulting in superior tumor control. Our studies highlight miR-23a in tumor-specific CTLs as a clinically relevant target to enhance ACT. PMID:25949909

  11. Research Networking Systems: The State of Adoption at Institutions Aiming to Augment Translational Research Infrastructure

    PubMed Central

    Obeid, Jihad S; Johnson, Layne M; Stallings, Sarah; Eichmann, David

    2015-01-01

    Fostering collaborations across multiple disciplines within and across institutional boundaries is becoming increasingly important with the growing emphasis on translational research. As a result, Research Networking Systems that facilitate discovery of potential collaborators have received significant attention by institutions aiming to augment their research infrastructure. We have conducted a survey to assess the state of adoption of these new tools at the Clinical and Translational Science Award (CTSA) funded institutions. Survey results demonstrate that most CTSA funded institutions have either already adopted or were planning to adopt one of several available research networking systems. Moreover a good number of these institutions have exposed or plan to expose the data on research expertise using linked open data, an established approach to semantic web services. Preliminary exploration of these publically-available data shows promising utility in assessing cross-institutional collaborations. Further adoption of these technologies and analysis of the data are needed, however, before their impact on cross-institutional collaboration in research can be appreciated and measured. PMID:26491707

  12. Aerosol Delivery of Interleukin-2 in Combination with Adoptive Transfer of Natural Killer Cells for the Treatment of Lung Metastasis: Methodology and Effect.

    PubMed

    Kiany, Simin; Gordon, Nancy

    2016-01-01

    Natural killer (NK) cells are a subtype of lymphocytes with a major role as a host defense mechanism against tumor cells. Allogeneic NK cell therapy is being used as an alternative promising therapy for many different cancers. Interleukin-2 (IL-2) is a critical cytokine for NK cell proliferation, survival, and effector functions. Cytokine support is essential to activate, expand, and increase the life span of NK cells. Aerosol delivery of IL-2 in combination with adoptive transfer of NK cells offers a reasonable approach for the treatment of lung metastases as it avoids the deleterious side effects of systemic IL-2. Using a human OS mouse model, we demonstrated the efficacy of this approach. Combination therapy of aerosol IL-2 with NK cells resulted in a better therapeutic effect against OS lung metastases as compared with each therapy alone. Aerosol IL-2 selectively increased infiltration, retention, and proliferation of infused NK cells in the lung, and there was no local inflammation or toxicity in the lungs or any other organ. Our results demonstrate that delivery of IL-2 via the aerosol route offers a feasible and innovative approach to enhance the immunotherapeutic effect of NK cells against pulmonary metastases. In the following chapter, we describe the methodology and effect of this innovative therapeutic approach. PMID:27177675

  13. A SCHOOL AND HEALTH RECORD TRANSFER SYSTEM FOR MIGRATORY CHILDREN OF MIGRATORY AGRICULTURAL WORKERS (CALIFORNIA).

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento.

    THE CALIFORNIA STATE DEPARTMENT OF EDUCATION HAS ADOPTED A UNIFORM TRANSFER SYSTEM FOR CHILDREN OF MIGRATORY AGRICULTURAL WORKERS. EACH SCHOOL DISTRICT ENROLLING MIGRANT CHILDREN MUST COMPLETE A STANDARDIZED FORM FOR EACH MIGRANT CHILD AND FORWARD IT WITH THE PUPIL WHEN HE WITHDRAWS FROM SCHOOL. A COPY ALSO MUST BE FORWARDED TO THE STATE…

  14. NLS cargo transfer vehicle propulsion system

    NASA Astrophysics Data System (ADS)

    Hearn, Hank C.; Langford, G. K.

    1992-02-01

    The propulsion system of the Cargo Transfer Vehicle is designed to meet a wide range of requirements associated with the National Launch System (NLS) resupply function for Space Station Freedom. It provides both orbit adjustment and precise vehicle control capability, and is compatible with close proximity operation at the space station as well as return on the shuttle for ground refurbishment and reuse. Preliminary trade studies have resulted in designing and sizing an integrated bipropellant system using monomethyl hydrazine and nitrogen tetroxide. Design and analysis activities are continuing, and the design will evolve and mature as part of the NLS program.

  15. Nurses' Clinical Decision Making on Adopting a Wound Clinical Decision Support System.

    PubMed

    Khong, Peck Chui Betty; Hoi, Shu Yin; Holroyd, Eleanor; Wang, Wenru

    2015-07-01

    Healthcare information technology systems are considered the ideal tool to inculcate evidence-based nursing practices. The wound clinical decision support system was built locally to support nurses to manage pressure ulcer wounds in their daily practice. However, its adoption rate is not optimal. The study's objective was to discover the concepts that informed the RNs' decisions to adopt the wound clinical decision support system as an evidence-based technology in their nursing practice. This was an exploratory, descriptive, and qualitative design using face-to-face interviews, individual interviews, and active participatory observation. A purposive, theoretical sample of 14 RNs was recruited from one of the largest public tertiary hospitals in Singapore after obtaining ethics approval. After consenting, the nurses were interviewed and observed separately. Recruitment stopped when data saturation was reached. All transcribed interview data underwent a concurrent thematic analysis, whereas observational data were content analyzed independently and subsequently triangulated with the interview data. Eight emerging themes were identified, namely, use of the wound clinical decision support system, beliefs in the wound clinical decision support system, influences of the workplace culture, extent of the benefits, professional control over nursing practices, use of knowledge, gut feelings, and emotions (fear, doubt, and frustration). These themes represented the nurses' mental outlook as they made decisions on adopting the wound clinical decision support system in light of the complexities of their roles and workloads. This research has provided insight on the nurses' thoughts regarding their decision to interact with the computer environment in a Singapore context. It captured the nurses' complex thoughts when deciding whether to adopt or reject information technology as they practice in a clinical setting. PMID:26066306

  16. Simulation of hydrogen adsorption systems adopting the flow through cooling concept

    SciTech Connect

    Corgnale, Claudio; Hardy, Bruce; Chahine, Richard; Cossement, Daniel; Tamburello, David; Anton, Donald

    2014-10-13

    Hydrogen storage systems based on adsorbent materials have the potential of achieving the U.S. Department of Energy (DOE) targets, especially in terms of gravimetric capacity. This paper deals with analysis of adsorption storage systems adopting the flow through cooling concept. By this approach the feeding hydrogen provides the needed cold to maintain the tank at low temperatures. Two adsorption systems have been examined and modeled adopting the Dubinin-Astakhov model, to see their performance under selected operating conditions. A first case has been analyzed, modeling a storage tank filled with carbon based material (namely MaxSorb®) and comparing the numerical outcomes with the available experimental results for a 2.5 L tank. Under selected operating conditions (minimum inlet hydrogen temperature of approximately 100 K and maximum pressure on the order of 8.5 MPa) and adopting the flow through cooling concept the material shows a gravimetric capacity of about 5.7 %. A second case has been modeled, examining the same tank filled with metal organic framework material (MOF5®) under approximately the same conditions. The model shows that the latter material can achieve a (material) gravimetric capacity on the order of 11%, making the system potentially able to achieve the DOE 2017 target.

  17. Simulation of hydrogen adsorption systems adopting the flow through cooling concept

    DOE PAGESBeta

    Corgnale, Claudio; Hardy, Bruce; Chahine, Richard; Cossement, Daniel; Tamburello, David; Anton, Donald

    2014-10-13

    Hydrogen storage systems based on adsorbent materials have the potential of achieving the U.S. Department of Energy (DOE) targets, especially in terms of gravimetric capacity. This paper deals with analysis of adsorption storage systems adopting the flow through cooling concept. By this approach the feeding hydrogen provides the needed cold to maintain the tank at low temperatures. Two adsorption systems have been examined and modeled adopting the Dubinin-Astakhov model, to see their performance under selected operating conditions. A first case has been analyzed, modeling a storage tank filled with carbon based material (namely MaxSorb®) and comparing the numerical outcomes withmore » the available experimental results for a 2.5 L tank. Under selected operating conditions (minimum inlet hydrogen temperature of approximately 100 K and maximum pressure on the order of 8.5 MPa) and adopting the flow through cooling concept the material shows a gravimetric capacity of about 5.7 %. A second case has been modeled, examining the same tank filled with metal organic framework material (MOF5®) under approximately the same conditions. The model shows that the latter material can achieve a (material) gravimetric capacity on the order of 11%, making the system potentially able to achieve the DOE 2017 target.« less

  18. Advanced orbit transfer vehicle propulsion system study

    NASA Technical Reports Server (NTRS)

    Cathcart, J. A.; Cooper, T. W.; Corringrato, R. M.; Cronau, S. T.; Forgie, S. C.; Harder, M. J.; Mcallister, J. G.; Rudman, T. J.; Stoneback, V. W.

    1985-01-01

    A reuseable orbit transfer vehicle concept was defined and subsequent recommendations for the design criteria of an advanced LO2/LH2 engine were presented. The major characteristics of the vehicle preliminary design include a low lift to drag aerocapture capability, main propulsion system failure criteria of fail operational/fail safe, and either two main engines with an attitude control system for backup or three main engines to meet the failure criteria. A maintenance and servicing approach was also established for the advanced vehicle and engine concepts. Design tradeoff study conclusions were based on the consideration of reliability, performance, life cycle costs, and mission flexibility.

  19. Transfer to Orbit System in NBS

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Two years prior to being used during a shuttle mission, the Transfer to Orbit System (TOS) is being demonstrated at Marshall Space Flight Center's (MSFC) Neutral Buoyancy Simulator (NBS). TOS is an upper stage launch system used to place satellites into higher orbits. TOS was used only once, on September 12, 1993 when the Space Shuttle Discovery (STS51) deployed ACTS (Advanced Communications Technology Satellite). The test pictured was to provide an evaluation of the extravehicular activity (EVA) tools that were to be used by future shuttle crews.

  20. Air Storage System Energy Transfer (ASSET) plants

    NASA Astrophysics Data System (ADS)

    Stys, Z. S.

    1983-09-01

    The design features and performance capabilities of Air Storage System Energy Transfer (ASSET) plants for transferring off-peak utility electricity to on-peak hours are described. The plant operations involve compressing ambient air with an axial flow compressor and depositing it in an underground reservoir at 70 bar pressure. Released during a peaking cycle, the pressure is reduced to 43 bar, the air is heated to 550 C, passed through an expander after a turbine, and passed through a low pressure combustion chamber to be heated to 850 C. A West German plant built in 1978 to supply over 300 MW continuous power for up to two hours is detailed, noting its availability factor of nearly 98 percent and power delivery cost of $230/kW installed. A plant being constructed in Illinois will use limestone caverns as the air storage tank.

  1. Long range inductive power transfer system

    NASA Astrophysics Data System (ADS)

    Lawson, James; Pinuela, Manuel; Yates, David C.; Lucyszyn, Stepan; Mitcheson, Paul D.

    2013-12-01

    We report upon a recently developed long range inductive power transfer system (IPT) designed to power remote sensors with mW level power consumption at distances up to 7 m. In this paper an inductive link is established between a large planar (1 × 1 m) transmit coil (Tx) and a small planer (170 × 170 mm) receiver coil (Rx), demonstrating the viability of highly asymmetrical coil configurations that real-world applications such as sensor networks impose. High Q factor Tx and Rx coils required for viable power transfer efficiencies over such distances are measured using a resonant method. The applicability of the Class-E amplifier in very low magnetic coupling scenarios and at the high frequencies of operation required for high Q operation is demonstrated by its usage as the Tx coil driver.

  2. 46 CFR 153.430 - Heat transfer systems; general.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Heat transfer systems; general. 153.430 Section 153.430... Temperature Control Systems § 153.430 Heat transfer systems; general. Each cargo cooling system required by... transfer rate....

  3. 46 CFR 153.430 - Heat transfer systems; general.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Heat transfer systems; general. 153.430 Section 153.430... Temperature Control Systems § 153.430 Heat transfer systems; general. Each cargo cooling system required by... transfer rate....

  4. 46 CFR 153.430 - Heat transfer systems; general.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Heat transfer systems; general. 153.430 Section 153.430... Temperature Control Systems § 153.430 Heat transfer systems; general. Each cargo cooling system required by... transfer rate....

  5. 46 CFR 153.430 - Heat transfer systems; general.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Heat transfer systems; general. 153.430 Section 153.430... Temperature Control Systems § 153.430 Heat transfer systems; general. Each cargo cooling system required by... transfer rate....

  6. Performance assessment and adoption processes of an information monitoring and diagnostic system prototype

    SciTech Connect

    Piette, Mary Ann

    1999-10-01

    This report addresses the problem that buildings do not perform as well as anticipated during design. We partnered with an innovative building operator to evaluate a prototype Information Monitoring and Diagnostic System (IMDS). The IMDS consists of high-quality measurements archived each minute, a data visualization tool, and a web-based capability. The operators recommend similar technology be adopted in other buildings. The IMDS has been used to identify and correct a series of control problems. It has also allowed the operators to make more effective use of the building control system, freeing up time to take care of other tenant needs. They believe they have significantly improved building comfort, potentially improving tenant health, and productivity. The reduction in hours to operate the building are worth about $20,000 per year, which could pay for the IMDS in about five years. A control system retrofit based on findings from the IMDS is expected to reduce energy use by 20 percent over the next year, worth over $30,000 per year. The main conclusion of the model-based chiller fault detection work is that steady-state models can be used as reference models to monitor chiller operation and detect faults. The ability of the IMDS to measure cooling load and chiller power to one-percent accuracy with a one-minute sampling interval permits detection of additional faults. Evolutionary programming techniques were also evaluated, showing promise in the detection of patterns in building data. We also evaluated two technology adoption processes, radical and routine. In routine adoption, managers enhance features of existing products that are already well understood. In radical adoption, innovative building managers introduce novel technology into their organizations without using the rigorous payback criteria used in routine innovations.

  7. Submersible pumping system with heat transfer mechanism

    SciTech Connect

    Hunt, Daniel Francis Alan; Prenger, F. Coyne; Hill, Dallas D; Jankowski, Todd Andrew

    2014-04-15

    A submersible pumping system for downhole use in extracting fluids containing hydrocarbons from a well. In one embodiment, the pumping system comprises a rotary induction motor, a motor casing, one or more pump stages, and a cooling system. The rotary induction motor rotates a shaft about a longitudinal axis of rotation. The motor casing houses the rotary induction motor such that the rotary induction motor is held in fluid isolation from the fluid being extracted. The pump stages are attached to the shaft outside of the motor casing, and are configured to impart fluid being extracted from the well with an increased pressure. The cooling system is disposed at least partially within the motor casing, and transfers heat generated by operation of the rotary induction motor out of the motor casing.

  8. Bagless Transfer System Welder Analysis Software

    SciTech Connect

    Collins, Susan L.

    2003-10-01

    The Bagless Transfer System Welder Analysis Software (BTS WAS) was developed by SRTC for use with the Bagless Transfer System. During the welding process, critical weld parameters such as weld current and voltage, can give valuable informaitoin about the weld. In the past, weld data from the TIG welding process, such as the bagless transfer system in FB-Line, has been monitored using strip chart recorders. The data from the weld process, recorded on the strip chart recorder traces, were reviewed by the supervisor using a procedure and criteria to analyze the weld. This hand checking can be tedious and time consuming. To improve this process, another software package developed by SRTC, the BTS DAS, digitizes the weld data and stores the weld data in a file. The BTS WAS automates the weld analysis process by analyzing the data obtained during the weld process against the same weld criteria that the supervisor currently users. Of course with the automated analysis system the supervisor is still provided the same information in the same chart display format so he can also manually review the data as desired. The BTS WAS reads in a data file that was prevously collected using the BTS DAS software. The software will read the file and parse the data. The user is first prompted to enter the file name. The file is then opened and the operator name and Date/Time of Acquisition are read from the file and displayed on the screen. The binary weld data is then read from the file into an array until the end of the file is reached. The shunt and weld current, voltage, RPM, and position data are displayed on the screen in graphical formats on the front panel. The weld power and resistance are calculated and are also displayed in graphical format on the front panel. Individual tack analysis data is provided for each of the three tacks. The main weld and downslope data is also displayed.

  9. Oxygen Transfer Characteristics of Miniaturized Bioreactor Systems

    PubMed Central

    Kirk, Timothy V; Szita, Nicolas

    2013-01-01

    Since their introduction in 2001 miniaturized bioreactor systems have made great advances in function and performance. In this article the dissolved oxygen (DO) transfer performance of submilliliter microbioreactors, and 1–10 mL minibioreactors was examined. Microbioreactors have reached kLa values of 460 h-1, and are offering instrumentation and some functionality comparable to production systems, but at high throughput screening volumes. Minibioreactors, aside from one 1,440 h-1 kLa system, have not offered as high rates of DO transfer, but have demonstrated superior integration with automated fluid handling systems. Microbioreactors have been typically limited to studies with E. coli, while minibioreactors have offered greater versatility in this regard. Further, mathematical relationships confirming the applicability of kLa measurements across all scales have been derived, and alternatives to fluorescence lifetime DO sensors have been evaluated. Finally, the influence on reactor performance of oxygen uptake rate (OUR), and the possibility of its real-time measurement have been explored. Biotechnol. Bioeng. 2013; 110: 1005–1019. © 2012 Wiley Periodicals, Inc. PMID:23280578

  10. Leukocytes expressing green fluorescent protein as novel reagents for adoptive cell transfer and bone marrow transplantation studies.

    PubMed

    Manfra, D J; Chen, S C; Yang, T Y; Sullivan, L; Wiekowski, M T; Abbondanzo, S; Vassileva, G; Zalamea, P; Cook, D N; Lira, S A

    2001-01-01

    Transgenic mice expressing green fluorescent protein (GFP) were generated to provide a source of labeled leukocytes for cell transfer studies. The transgene comprises the GFP coding region under the transcriptional control of the chicken ss-actin promoter and human cytomegalovirus enhancer. Mice expressing this GFP transgene were generated in the B6D2 and in the 129SvEv backgrounds. Flow cytometric analysis of cells from the blood, spleen, and bone marrow of these transgenic mice revealed that most leukocytes, including dendritic cells and memory T cells, express GFP. In allogeneic cell transfers, donor GFP+ splenocytes were detected in the spleen and mesenteric lymph nodes of recipient mice within 2 hours after transfer and for at least 9 days thereafter. In syngeneic experiments using 129-derived GFP+ donor splenocytes, donor cells were detected in multiple tissues of 129 recipients from 2 hours to 3 weeks after transfer. In bone-marrow transplantation experiments using irradiated allogeneic recipients, the percent of GFP+ donor cells in recipients at 3 weeks was comparable to that seen in similar tissues of GFP+ donor mice. These data demonstrate that GFP+ transgenic mice provide a ready source of GFP-expressing primary cells that can be easily monitored after their transfer to recipient animals. PMID:11141477

  11. Leukocytes Expressing Green Fluorescent Protein as Novel Reagents for Adoptive Cell Transfer and Bone Marrow Transplantation Studies

    PubMed Central

    Manfra, Denise J.; Chen, Shu-Cheng; Yang, Tong-Yuan; Sullivan, Lee; Wiekowski, Maria T.; Abbondanzo, Susan; Vassileva, Galya; Zalamea, Petronio; Cook, Donald N.; Lira, Sergio A.

    2001-01-01

    Transgenic mice expressing green fluorescent protein (GFP) were generated to provide a source of labeled leukocytes for cell transfer studies. The transgene comprises the GFP coding region under the transcriptional control of the chicken β-actin promoter and human cytomegalovirus enhancer. Mice expressing this GFP transgene were generated in the B6D2 and in the 129SvEv backgrounds. Flow cytometric analysis of cells from the blood, spleen, and bone marrow of these transgenic mice revealed that most leukocytes, including dendritic cells and memory T cells, express GFP. In allogeneic cell transfers, donor GFP+ splenocytes were detected in the spleen and mesenteric lymph nodes of recipient mice within 2 hours after transfer and for at least 9 days thereafter. In syngeneic experiments using 129-derived GFP+ donor splenocytes, donor cells were detected in multiple tissues of 129 recipients from 2 hours to 3 weeks after transfer. In bone-marrow transplantation experiments using irradiated allogeneic recipients, the percent of GFP+ donor cells in recipients at 3 weeks was comparable to that seen in similar tissues of GFP+ donor mice. These data demonstrate that GFP+ transgenic mice provide a ready source of GFP-expressing primary cells that can be easily monitored after their transfer to recipient animals. PMID:11141477

  12. Load transfer mechanisms in anchored geosynthetic systems

    NASA Astrophysics Data System (ADS)

    Hryciw, Roman D.

    1990-12-01

    Success of an anchored geosynthetic system (AGS) depends on the satisfactory transfer of load between: the surface-deployed geosynthetic and anchors (typically ribbed reinforcing rods) driven into the slope; the geosynthetic and soil; and the anchors and soil. A study was performed to evaluate the load transfer mechanisms at these interfaces in an AGS. A mathematical model was developed for predicting the pullout resistance of plane ribbed inclusions. The model considered the contribution of both frictional and passive resistance components of pullout resistance. Optical observation of sand around the ribs was made to determine the behavior of soil around the moving ribs during pullout. A theoretical study disclosed that the optimum anchor orientation for stabilization of infinite slopes depends on several factors including slope angle and in-situ stresses. It typically ranges from 20 to 30 degree from the normal to the slope with the anchor driven upslope. An experimental study confirmed that the soil-geosynthetic interface friction angle may be correctly predicted from the residual or critical state friction angle of the sand. Equations were developed for load transfer at curved soil-fabric interfaces. An experimental study verified that the increases in soil stress with distance from the anchor may be predicted by the developed equations.

  13. Adopting a Cultural Portfolio Project in Teaching German as a Foreign Language: Language Teacher Cognition as a Dynamic System

    ERIC Educational Resources Information Center

    Feryok, Anne; Oranje, Jo

    2015-01-01

    Intercultural language teaching and learning has increasingly been adopted in state school systems, yet studies have shown that language teachers struggle to include it in their practice. The aim of this study is to use dynamic systems theory to examine how a German as a foreign language teacher in a New Zealand secondary school adopted a project…

  14. Satellite services system analysis study: Propellant transfer system

    NASA Technical Reports Server (NTRS)

    1982-01-01

    General servicing requirements, a servicing mission concept and scenario, overall servicing needs, basic servicing equipment, and a general servicing mission configuration layout are addressed. Servicing needs, equipment concepts, system requirements equipment specifications, preliminary designs, and resource requirements for flight hardware for the propellant transfer system are also addressed.

  15. Enabling the BC Transfer System: A Discussion Paper

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2011

    2011-01-01

    This discussion paper outlines processes, as well as opportunities and constraints, for "enabling" BC Transfer System institutions to enhance transfer credit information in the BC Transfer Guide, making it more reflective of institutional practices and student mobility. BCCAT's focus is increasing the availability of transfer credit information…

  16. Recalibrating the BC Transfer System: Approved Final Report

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2006

    2006-01-01

    In November 2005, the BC Council on Admissions and Transfer launched a consultation entitled Recalibrating the BC Transfer System with the institutional members of the BC Transfer System and other interested parties. This consultation was motivated in large part by significant changes in the BC post-secondary system over the last decade, and…

  17. Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice.

    PubMed

    Liu, X; Barrett, D M; Jiang, S; Fang, C; Kalos, M; Grupp, S A; June, C H; Zhao, Y

    2016-01-01

    Despite the impressive clinical efficacy of T cells engineered to express chimeric antigen receptors (CAR-Ts), the current applications of CAR-T cell therapy are limited by major treatment-related toxicity. Thus, safer yet effective alternative approaches must be developed. In this study, we compared CD19 bispecific T-cell engager (BiTE)-transferred T cells that had been transfected by RNA electroporation with CD19 CAR RNA-transferred T cells both in vitro and in an aggressive Nalm6 leukemia mouse model. BiTEs were secreted from the transferred T cells and enabled both the transferred and bystander T cells to specifically recognize CD19(+) cell lines, with increased tumor killing ability, prolonged functional persistence, increased cytokine production and potent proliferation compared with the CAR-T cells. More interestingly, in comparison with CD3/CD28 bead-stimulated T cells, T cells that were expanded by a rapid T-cell expansion protocol (REP) showed enhanced anti-tumor activities for both CAR and BiTE RNA-electroporated T cells both in vitro and in a Nalm6 mouse model (P<0.01). Furthermore, the REP T cells with BiTE RNAs showed greater efficacy in the Nalm6 leukemia model compared with REP T cells with CAR RNA (P<0.05) and resulted in complete leukemia remission. PMID:27258611

  18. Transfer zones in listric normal fault systems

    NASA Astrophysics Data System (ADS)

    Bose, Shamik

    Listric normal faults are common in passive margin settings where sedimentary units are detached above weaker lithological units, such as evaporites or are driven by basal structural and stratigraphic discontinuities. The geometries and styles of faulting vary with the types of detachment and form landward and basinward dipping fault systems. Complex transfer zones therefore develop along the terminations of adjacent faults where deformation is accommodated by secondary faults, often below seismic resolution. The rollover geometry and secondary faults within the hanging wall of the major faults also vary with the styles of faulting and contribute to the complexity of the transfer zones. This study tries to understand the controlling factors for the formation of the different styles of listric normal faults and the different transfer zones formed within them, by using analog clay experimental models. Detailed analyses with respect to fault orientation, density and connectivity have been performed on the experiments in order to gather insights on the structural controls and the resulting geometries. A new high resolution 3D laser scanning technology has been introduced to scan the surfaces of the clay experiments for accurate measurements and 3D visualizations. Numerous examples from the Gulf of Mexico have been included to demonstrate and geometrically compare the observations in experiments and real structures. A salt cored convergent transfer zone from the South Timbalier Block 54, offshore Louisiana has been analyzed in detail to understand the evolutionary history of the region, which helps in deciphering the kinematic growth of similar structures in the Gulf of Mexico. The dissertation is divided into three chapters, written in a journal article format, that deal with three different aspects in understanding the listric normal fault systems and the transfer zones so formed. The first chapter involves clay experimental models to understand the fault patterns in

  19. Temporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis.

    PubMed

    Doerck, Sebastian; Göbel, Kerstin; Weise, Gesa; Schneider-Hohendorf, Tilman; Reinhardt, Michael; Hauff, Peter; Schwab, Nicholas; Linker, Ralf; Mäurer, Mathias; Meuth, Sven G; Wiendl, Heinz

    2010-01-01

    Migration of immune cells to the target organ plays a key role in autoimmune disorders like multiple sclerosis (MS). However, the exact underlying mechanisms of this active process during autoimmune lesion pathogenesis remain elusive. To test if pro-inflammatory and regulatory T cells migrate via a similar molecular mechanism, we analyzed the expression of different adhesion molecules, as well as the composition of infiltrating T cells in an in vivo model of MS, adoptive transfer experimental autoimmune encephalomyelitis in rats. We found that the upregulation of ICAM-I and VCAM-I parallels the development of clinical disease onset, but persists on elevated levels also in the phase of clinical remission. However, the composition of infiltrating T cells found in the developing versus resolving lesion phase changed over time, containing increased numbers of regulatory T cells (FoxP3) only in the phase of clinical remission. In order to test the relevance of the expression of cell adhesion molecules, animals were treated with purified antibodies to ICAM-I and VCAM-I either in the phase of active disease or in early remission. Treatment with a blocking ICAM-I antibody in the phase of disease progression led to a milder disease course. However, administration during early clinical remission aggravates clinical symptoms. Treatment with anti-VCAM-I at different timepoints had no significant effect on the disease course. In summary, our results indicate that adhesion molecules are not only important for capture and migration of pro-inflammatory T cells into the central nervous system, but also permit access of anti-inflammatory cells, such as regulatory T cells. Therefore it is likely to assume that intervention at the blood brain barrier is time dependent and could result in different therapeutic outcomes depending on the phase of CNS lesion development. PMID:21085578

  20. Case report: Taiwan's experience in adopting IHE technical framework to integrate systems.

    PubMed

    Lian, Jenn-Dong; Lin, I-Chun; Wu, Hsiang-Chin

    2006-01-01

    Though more and more hospitals adopt PACS in Taiwan, they all meet the same problem of system integration. The Integrating the Healthcare Enterprise (IHE) association proposes an integrated technical framework and process profiles to solve problems of heterogeneous system integration in medical environment for information sharing. Therefore, this paper reports the experience of a case hospital that successfully applied IHE framework to integrate its HIS, RIS and PACS in Taiwan. This paper indicates that using the IHE can help evaluate the integration ability of PACS vendors, enhance staff's ability, shorten the PACS implementation time, reduce the cost, and reserve system's expansibility. The case hospital was able to successfully implement it's PACS because of executive's full support, using the standard, and providing complete training to reduce user's resistance. This paper not only shares the experiences of IHE adoption of a case hospital but also summarizes key factors to implement PACS successfully. Again, this paper confirms that standard is helpful to integrate heterogeneous system. PMID:17102437

  1. 46 CFR 153.430 - Heat transfer systems; general.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Heat transfer systems; general. 153.430 Section 153.430... Temperature Control Systems § 153.430 Heat transfer systems; general. Each cargo cooling system required by... separated from all other cooling and heating systems; and (c) Allow manual regulation of the system's...

  2. Memory T cells specific for murine cytomegalovirus re-emerge after multiple challenges and recapitulate immunity in various adoptive transfer scenarios.

    PubMed

    Quinn, Michael; Turula, Holly; Tandon, Mayank; Deslouches, Berthony; Moghbeli, Toktam; Snyder, Christopher M

    2015-02-15

    Reconstitution of CMV-specific immunity after transplant remains a primary clinical objective to prevent CMV disease, and adoptive immunotherapy of CMV-specific T cells can be an effective therapeutic approach. Because of viral persistence, most CMV-specific CD8(+) T cells become terminally differentiated effector phenotype CD8(+) T cells (TEFF). A minor subset retains a memory-like phenotype (memory phenotype CD8(+) T cells [TM]), but it is unknown whether these cells retain memory function or persist over time. Interestingly, recent studies suggest that CMV-specific CD8(+) T cells with different phenotypes have different abilities to reconstitute sustained immunity after transfer. The immunology of human CMV infections is reflected in the murine CMV (MCMV) model. We found that human CMV- and MCMV-specific T cells displayed shared genetic programs, validating the MCMV model for studies of CMV-specific T cells in vivo. The MCMV-specific TM population was stable over time and retained a proliferative capacity that was vastly superior to TEFF. Strikingly, after transfer, TM established sustained and diverse T cell populations even after multiple challenges. Although both TEFF and TM could protect Rag(-/-) mice, only TM persisted after transfer into immune replete, latently infected recipients and responded if recipient immunity was lost. Interestingly, transferred TM did not expand until recipient immunity was lost, supporting that competition limits the Ag stimulation of TM. Ultimately, these data show that CMV-specific TM retain memory function during MCMV infection and can re-establish CMV immunity when necessary. Thus, TM may be a critical component for consistent, long-term adoptive immunotherapy success. PMID:25595792

  3. Bagless Transfer System Welder Analysis Software

    2003-10-01

    The Bagless Transfer System Welder Analysis Software (BTS WAS) was developed by SRTC for use with the Bagless Transfer System. During the welding process, critical weld parameters such as weld current and voltage, can give valuable informaitoin about the weld. In the past, weld data from the TIG welding process, such as the bagless transfer system in FB-Line, has been monitored using strip chart recorders. The data from the weld process, recorded on the stripmore » chart recorder traces, were reviewed by the supervisor using a procedure and criteria to analyze the weld. This hand checking can be tedious and time consuming. To improve this process, another software package developed by SRTC, the BTS DAS, digitizes the weld data and stores the weld data in a file. The BTS WAS automates the weld analysis process by analyzing the data obtained during the weld process against the same weld criteria that the supervisor currently users. Of course with the automated analysis system the supervisor is still provided the same information in the same chart display format so he can also manually review the data as desired. The BTS WAS reads in a data file that was prevously collected using the BTS DAS software. The software will read the file and parse the data. The user is first prompted to enter the file name. The file is then opened and the operator name and Date/Time of Acquisition are read from the file and displayed on the screen. The binary weld data is then read from the file into an array until the end of the file is reached. The shunt and weld current, voltage, RPM, and position data are displayed on the screen in graphical formats on the front panel. The weld power and resistance are calculated and are also displayed in graphical format on the front panel. Individual tack analysis data is provided for each of the three tacks. The main weld and downslope data is also displayed.« less

  4. The Family of Adoption.

    ERIC Educational Resources Information Center

    Pavao, Joyce Maguire

    This book aims to provide a broad framework within which to think about adoption as a whole system, so that everyone involved will learn to feel some empathy for the other members of the adoption process. The book, written by a family and adoption therapist who was adopted as an infant, describes predictable developmental stages and challenges for…

  5. Intimate Relationship Challenges in Early Parenthood among Lesbian, Gay, and Heterosexual Couples Adopting via the Child Welfare System.

    PubMed

    Goldberg, Abbie E; Kinkler, Lori A; Moyer, April M; Weber, Elizabeth

    2014-08-01

    Little research has examined the transition to parenthood among couples who adopt through the child welfare system. The current qualitative study of 84 individuals within 42 couples (17 lesbian, 13 gay, and 12 heterosexual), who were placed with a child via foster care three months earlier, examined perceived changes in their intimate relationship. Findings indicated that, like heterosexual biological-parent couples, some adoptive parents perceived the loss of their partner's undivided attention as stressful to the relationship. Adoption-specific stressors were also identified, including the need to find state-approved child care to facilitate "couple time" and the legal insecurity of foster-to-adopt placements. Although our findings were similar for heterosexual, lesbian, and gay adoptive parents, same-sex couples cited some additional stressors related to their sexual minority status. Findings have implications for individual, couple, and family practitioners who work with lesbian, gay, and heterosexual adoptive parents, particularly during their transition to parenthood. PMID:25177080

  6. "It's about Us": Marital Adjustment and Marital Adaptation in Couples Who Adopt Children from the Child Welfare System

    ERIC Educational Resources Information Center

    Mooradian, John K.; Timm, Tina M.; Hock, Robert M.; Jackson, Rosemary

    2011-01-01

    This article examines, using grounded theory methodology, the marital relationships of couples who adopted children from the child welfare system. Twenty-two spouses in four focus groups reported initial marital adjustment that featured husbands' support of their wives' initiation of adoption and management of child needs. About one half of these…

  7. Course Transfer Guide, 1983. University of Nevada System.

    ERIC Educational Resources Information Center

    Pinkham, Karen L., Ed.

    Designed for students planning to transfer within the University of Nevada (UN) System, this guide provides general information and specific data on the transfer status of courses offered by the four community colleges in the system. Introductory material provides information on UN admissions, transfer courses, course numbering, curriculum…

  8. A knowledge-based taxonomy of critical factors for adopting electronic health record systems by physicians: a systematic literature review

    PubMed Central

    2010-01-01

    Background The health care sector is an area of social and economic interest in several countries; therefore, there have been lots of efforts in the use of electronic health records. Nevertheless, there is evidence suggesting that these systems have not been adopted as it was expected, and although there are some proposals to support their adoption, the proposed support is not by means of information and communication technology which can provide automatic tools of support. The aim of this study is to identify the critical adoption factors for electronic health records by physicians and to use them as a guide to support their adoption process automatically. Methods This paper presents, based on the PRISMA statement, a systematic literature review in electronic databases with adoption studies of electronic health records published in English. Software applications that manage and process the data in the electronic health record have been considered, i.e.: computerized physician prescription, electronic medical records, and electronic capture of clinical data. Our review was conducted with the purpose of obtaining a taxonomy of the physicians main barriers for adopting electronic health records, that can be addressed by means of information and communication technology; in particular with the information technology roles of the knowledge management processes. Which take us to the question that we want to address in this work: "What are the critical adoption factors of electronic health records that can be supported by information and communication technology?". Reports from eight databases covering electronic health records adoption studies in the medical domain, in particular those focused on physicians, were analyzed. Results The review identifies two main issues: 1) a knowledge-based classification of critical factors for adopting electronic health records by physicians; and 2) the definition of a base for the design of a conceptual framework for supporting the

  9. A single exercise bout enhances the manufacture of viral-specific T-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy.

    PubMed

    Spielmann, Guillaume; Bollard, Catherine M; Kunz, Hawley; Hanley, Patrick J; Simpson, Richard J

    2016-01-01

    Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). The adoptive transfer of donor-derived viral-specific cytotoxic T-cells (VSTs) is an effective treatment for controlling CMV and EBV infections after HSCT; however, new practical methods are required to augment the ex vivo manufacture of multi-VSTs from healthy donors. This study investigated the effects of a single exercise bout on the ex vivo manufacture of multi-VSTs. PBMCs isolated from healthy CMV/EBV seropositive participants before (PRE) and immediately after (POST) 30-minutes of cycling exercise were stimulated with CMV (pp65 and IE1) and EBV (LMP2A and BMLF1) peptides and expanded over 8 days. The number (fold difference from PRE) of T-cells specific for CMV pp65 (2.6), EBV LMP2A (2.5), and EBV BMLF1 (4.4) was greater among the VSTs expanded POST. VSTs expanded PRE and POST had similar phenotype characteristics and were equally capable of MHC-restricted killing of autologous target cells. We conclude that a single exercise bout enhances the manufacture of multi-VSTs from healthy donors without altering their phenotype or function and may serve as a simple and economical adjuvant to boost the production of multi-VSTs for allogeneic adoptive transfer immunotherapy. PMID:27181409

  10. A single exercise bout enhances the manufacture of viral-specific T-cells from healthy donors: implications for allogeneic adoptive transfer immunotherapy

    PubMed Central

    Spielmann, Guillaume; Bollard, Catherine M.; Kunz, Hawley; Hanley, Patrick J.; Simpson, Richard J.

    2016-01-01

    Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections remain a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). The adoptive transfer of donor-derived viral-specific cytotoxic T-cells (VSTs) is an effective treatment for controlling CMV and EBV infections after HSCT; however, new practical methods are required to augment the ex vivo manufacture of multi-VSTs from healthy donors. This study investigated the effects of a single exercise bout on the ex vivo manufacture of multi-VSTs. PBMCs isolated from healthy CMV/EBV seropositive participants before (PRE) and immediately after (POST) 30-minutes of cycling exercise were stimulated with CMV (pp65 and IE1) and EBV (LMP2A and BMLF1) peptides and expanded over 8 days. The number (fold difference from PRE) of T-cells specific for CMV pp65 (2.6), EBV LMP2A (2.5), and EBV BMLF1 (4.4) was greater among the VSTs expanded POST. VSTs expanded PRE and POST had similar phenotype characteristics and were equally capable of MHC-restricted killing of autologous target cells. We conclude that a single exercise bout enhances the manufacture of multi-VSTs from healthy donors without altering their phenotype or function and may serve as a simple and economical adjuvant to boost the production of multi-VSTs for allogeneic adoptive transfer immunotherapy. PMID:27181409

  11. Towards a mLearning training solution to the adoption of a CPOE system.

    PubMed

    Pakonstantinou, Despoina; Poulymenopoulou, Mikaela; Malamateniou, Flora; Vassilacopoulos, George

    2012-01-01

    Computerized Physician Order Entry (CPOE) has been introduced as a solution that can fundamentally change the way healthcare is provided, affecting all types of healthcare stakeholders and improving healthcare decisions, patient outcomes, patient safety and efficiency. However, a relatively small proportion of healthcare organizations have implemented CPOE systems, due to its technological complexity and to its low acceptance rate by healthcare professionals who largely disregard the value of CPOE in efficient healthcare delivery. An online training facility embedded within a CPOE service may increase the likelihood of its adoption by healthcare professionals as it offers them guidelines on how to perform each task of the CPOE service. In contrast to CPOE, on the other hand, handheld devices and other mobile technologies have showed an increased adoption rate. This paper considers a CPOE service that can be accessed by authorized healthcare professionals through their mobile devices anytime anywhere, and allows embedded training content, which has been developed through a learning management system (LMS) to be presented to the user automatically upon request. PMID:22874338

  12. An Adoption Diffusion Model of RFID-Based Livestock Management System in Australia

    NASA Astrophysics Data System (ADS)

    Hossain, Mohammad Alamgir; Quaddus, Mohammed

    Many countries, like Australia, have introduced a radio frequency identifi cation (RFID) based livestock identification and management system,which can be used for condition monitoring and fault prognosis during an outbreak situation. This paper examines the adoption process and its subsequent diffusion and extended usage of RFID in Australian livestock management practices, and proposes a research model. The model is primarily built on Rogers' innovation-diffusion theory and Oliver's expectation-confirmation theory, with some logical modifications. It posits that while adoption of RFID may be the result of legislative pressure, its further diffusion is an evaluative process, which is judged against "satisfaction" and "performance" derived from RFID systems. The implications of these and other related concepts are also discussed. Hypotheses are developed which can be tested via empirical study. The proposed model has both theoretical and practical implications. Although it is developed on the basis of the Australian livestock industry, it can be used in other countries and also in other applications with some industry-specific modifications.

  13. Characteristics of German hospitals adopting health IT systems - results from an empirical study.

    PubMed

    Liebe, Jan-David; Egbert, Nicole; Frey, Andreas; Hübner, Ursula

    2011-01-01

    Hospital characteristics that facilitate IT adoption have been described by the literature extensively, however with controversial results. The aim of this study therefore is to draw a set of the most important variables from previous studies and include them in a combined analysis for testing their contribution as single factors and their interactions. Total number of IT systems installed and number of clinical IT systems in the hospital were used as criterion variables. Data from a national survey of German hospitals served as basis. Based on a stepwise multiple regression analysis four variables were identified to significantly explain the degree of IT adoption (60% explained variance): 1) hospital size, 2) IT department, 3) reference customer and 4) ownership (private vs. public). Our results replicate previous findings with regard to hospital size and ownership. In addition our study emphasizes the importance of a reliable internal structure for IT projects (existence of an IT department) and the culture of testing and installing most recent IT products (being a reference customer). None of the interactions between factors was significant. PMID:21893768

  14. HEAT TRANSFER AND TRITIUM PRODUCING SYSTEM

    DOEpatents

    Johnson, E.F.

    1962-06-01

    This invention related to a circulating lithium-containing blanket system in a neution source hav'ing a magnetic field associated therewith. The blanket serves simultaneously and efficiently as a heat transfer mediunm and as a source of tritium. The blanket is composed of a lithium-6-enriched fused salt selected from the group consisting of lithium nitrite, lithium nitrate, a mixture of said salts, a mixture of each of said salts with lithium oxide, and a mixture of said salts with each other and with lithium oxide. The moderator, which is contained within the blanket in a separate conduit, can be water. A stellarator is one of the neutron sources which can be used in this invention. (AEC)

  15. Infrared radiative energy transfer in gaseous systems

    NASA Technical Reports Server (NTRS)

    Tiwari, Surendra N.

    1991-01-01

    Analyses and numerical procedures are presented to investigate the radiative interactions in various energy transfer processes in gaseous systems. Both gray and non-gray radiative formulations for absorption and emission by molecular gases are presented. The gray gas formulations are based on the Planck mean absorption coefficient and the non-gray formulations are based on the wide band model correlations for molecular absorption. Various relations for the radiative flux and divergence of radiative flux are developed. These are useful for different flow conditions and physical problems. Specific plans for obtaining extensive results for different cases are presented. The procedure developed was applied to several realistic problems. Results of selected studies are presented.

  16. Adoptive transfer of pTRP2-specific CTLs expanding by bead-based artificial antigen-presenting cells mediates anti-melanoma response.

    PubMed

    Lu, Xiaoling; Jiang, Xiaobing; Liu, Ruen; Zhao, Hongyang; Liang, Zhihui

    2008-11-18

    Cytotoxic CD8(+) T cells are key effectors in the immunotherapy of malignant and viral diseases. However, the lack of efficient methods for their in vitro priming and expansion has become a bottleneck to the development of vaccines and adoptive transfer strategies. Synthetic artificial antigen-presenting cells (aAPCs) are now emerging as an attractive tool for eliciting and expanding CTL responses. This study reported a novel approach for targeting malignant melanoma with pTRP2-specific cytotoxic T lymphocytes (CTLs) expanded from the C57BL/6 splenocytes by multiple stimulations with aAPCs made by coating H-2K(b)-Ig/pTRP2 dimeric complexes, anti-CD28 antibody, 4-1BBL molecules and CD83 molecules to cell-sized latex beads. The induced CTLs exhibited specific lysis against RMA-S cells pulsed with the peptide pTRP2 and H-2K(b+) melanoma cells expressing TRP2, while a murine Lewis lung carcinoma cell line 3LL could not be recognized by the CTLs. The peptide-specific activity was inhibited by anti-H-2K(b) monoclonal antibody Y3. Adoptive Transfer of CTLs specific for malignant melanoma expanding by the aAPCs can mediate effective anti-melanoma response. These results suggested the bead-based aAPCs coated with an MHC-Ig/peptide complex, anti-CD28 antibody, 4-1BBL and CD83 could provide a useful tool for the reproducible expansion of specific CTLs for adoptive immunotherapy. PMID:18621475

  17. Load-bearing masonry system adoption and performance: A case study of construction company in a developing country

    NASA Astrophysics Data System (ADS)

    Ramli, Nor Azlinda; Abdullah, Che Sobry; Nawi, Mohd Nasrun Mohd; Bahaudin, Ahmad Yusni

    2016-08-01

    This study addresses the factors that influence the adoption of load-bearing masonry (LBM) system. A case study of the load-bearing masonry (LBM) system adoption is conducted through an interview to explore the situation of the technology adoption in a construction company. The finding indicates the factors influence the adoption of LBM system for the construction company are: organizational resources, usefulness, less maintenance, reduce construction time and cost. From the findings, these factors consistent with previous literature. Furthermore, the performance of the company was measured by looking into the financial and non-financial aspects. The LBM system brings good performance as it increased the profits of the company, a good quality of product and attracts more demand from customers. Thus, these factors should be considered for the other companies that are interested in implementing the LBM system in their projects.

  18. Critical factors for the adoption of mobile nursing information systems in Taiwan: the nursing department administrators' perspective.

    PubMed

    Hsiao, Shih-Jung; Li, Yi-Chang; Chen, Ying-Ling; Ko, Hsi-Ching

    2009-10-01

    The trend towards point-of-care and the advance in mobile technologies bring the potential to employ Mobile Nursing Information Systems (MNIS) in nursing care routines. However, adopting the MNIS is not simply a case of purchasing the required hardware and software, but rather a social interaction process between users, organizations, and the environment. Therefore, this study developed a framework of twelve factors affecting the decision to adopt/not to adopt the MNIS in the nursing department, and tested it from the perspective of the nursing administrators. A mail survey was conducted to collect the opinions of 84 nursing administrators, and a discriminant analysis was used to identify the critical factors for the adoption/non-adoption of the MNIS. Business competition, external suppliers' support, and internal needs were identified as being significantly associated with the adoption of MNIS. Potential adopters can apply the results of this study as a reference when making the adoption decision regarding MNIS, while non-adopters and vendors can examine the resistance to MNIS. PMID:19827263

  19. Transfer matrix method for multibody systems for piezoelectric stack actuators

    NASA Astrophysics Data System (ADS)

    Zhu, Wei; Chen, Gangli; Bian, Leixiang; Rui, Xiaoting

    2014-09-01

    In order to achieve a large displacement output from a piezoelectric actuator, we realized the piezoelectric stack actuator (PSA) by mechanically layering/stacking multi-chip piezoelectric wafers in a series and electrically connecting the electrodes in parallel. In this paper, in order to accurately model the hysteresis and the dynamic characteristics of a PSA, the transfer matrix method for multibody systems (MSTMM) was adopted to describe the dynamic characteristics, and the Bouc-Wen hysteresis operator was used to represent the hysteresis. The vibration characteristics of a PSA and a piezo-actuated positioning mechanism (PPM) are derived and analyzed by the MSTMM; then, the dynamic responses of the PSA and the PPM are calculated. The experimental results show that the new method can accurately portray the hysteresis and the dynamic characteristics of a PSA and a PPM. On one hand, if we use this method to model the dynamic response of the PSA and the PPM, the PSA can be considered as a flexible body, as opposed to a mass-spring-damper system, which is in better agreement with the actual condition. On the other hand, the global dynamics equation is not needed for the study of system dynamics, and the dynamics equation has a small-sized matrix and a higher computational speed. Therefore, this method gives a broad range of possibilities for model-based controller design.

  20. Industrial Adoption of Model-Based Systems Engineering: Challenges and Strategies

    NASA Astrophysics Data System (ADS)

    Maheshwari, Apoorv

    As design teams are becoming more globally integrated, one of the biggest challenges is to efficiently communicate across the team. The increasing complexity and multi-disciplinary nature of the products are also making it difficult to keep track of all the information generated during the design process by these global team members. System engineers have identified Model-based Systems Engineering (MBSE) as a possible solution where the emphasis is placed on the application of visual modeling methods and best practices to systems engineering (SE) activities right from the beginning of the conceptual design phases through to the end of the product lifecycle. Despite several advantages, there are multiple challenges restricting the adoption of MBSE by industry. We mainly consider the following two challenges: a) Industry perceives MBSE just as a diagramming tool and does not see too much value in MBSE; b) Industrial adopters are skeptical if the products developed using MBSE approach will be accepted by the regulatory bodies. To provide counter evidence to the former challenge, we developed a generic framework for translation from an MBSE tool (Systems Modeling Language, SysML) to an analysis tool (Agent-Based Modeling, ABM). The translation is demonstrated using a simplified air traffic management problem and provides an example of a potential quite significant value: the ability to use MBSE representations directly in an analysis setting. For the latter challenge, we are developing a reference model that uses SysML to represent a generic infusion pump and SE process for planning, developing, and obtaining regulatory approval of a medical device. This reference model demonstrates how regulatory requirements can be captured effectively through model-based representations. We will present another case study at the end where we will apply the knowledge gained from both case studies to a UAV design problem.

  1. Bagless Transfer System Welder Data Acquisition Software

    SciTech Connect

    Collins, Susan L.

    2003-09-30

    The Bagless Transfer System Welder Data Acquisition Software (BTS DAS) was developed by SRTC to replace a strip chart recorder that has been in place since the design of the BTS. During the welding process, critical weld parameters such as weld current and voltage, can give valuable information about the weld. In the past, weld data from the TID welding process, has been monitored using strip chart recorders. The data from the weld process, recorded on the strip chart recorder traces, are reviewed to analyze the weld. The BTS DAS improves this technology by digitizing the weld data which allows for automation of the analysis process. Also, the data files are now stored digitally as well as a hard copy printout, so they can be reanalyzed if needed. The BTS DAS performs the necessary functions to perform the data acquisition functions during the BTS Welding Process. It is important to monitor the critical weld parameters, current and voltage, during a weld as they can be used to set acceptance criteria for weld acceptance. The software monitors and records the weld current, voltage, and RPM data. The welder DAS is a passive device and does not control the welder. The BTS control system interfaces directly with the welder and the BTS DAS. Digital handshaking is used between the BTS DAS and the BTS control system to ensure that the DAS is ready to weld prior to allowing the operator to initiate the welding process.

  2. Bagless Transfer System Welder Data Acquisition Software

    2003-09-30

    The Bagless Transfer System Welder Data Acquisition Software (BTS DAS) was developed by SRTC to replace a strip chart recorder that has been in place since the design of the BTS. During the welding process, critical weld parameters such as weld current and voltage, can give valuable information about the weld. In the past, weld data from the TID welding process, has been monitored using strip chart recorders. The data from the weld process, recordedmore » on the strip chart recorder traces, are reviewed to analyze the weld. The BTS DAS improves this technology by digitizing the weld data which allows for automation of the analysis process. Also, the data files are now stored digitally as well as a hard copy printout, so they can be reanalyzed if needed. The BTS DAS performs the necessary functions to perform the data acquisition functions during the BTS Welding Process. It is important to monitor the critical weld parameters, current and voltage, during a weld as they can be used to set acceptance criteria for weld acceptance. The software monitors and records the weld current, voltage, and RPM data. The welder DAS is a passive device and does not control the welder. The BTS control system interfaces directly with the welder and the BTS DAS. Digital handshaking is used between the BTS DAS and the BTS control system to ensure that the DAS is ready to weld prior to allowing the operator to initiate the welding process.« less

  3. A case study of one school system's adoption and implementation of an elementary science program

    NASA Astrophysics Data System (ADS)

    Kelly, Michael P.; Staver, John R.

    2005-01-01

    In this investigation we employed a case study approach with qualitative and quantitative data sources to examine and discover the characteristics of the processes used by a midwestern U.S. school system to adopt and implement a new K-6 science curriculum. Analysis of data yielded several results. Elementary teachers received what they requested, a hands-on science program with texts and kits. Teachers as a group remained in the early stages of the Concerns-Based Adoption Model profile of concerns. Many K-6 teachers remained uncomfortable with teaching science. Teachers' attitudes regarding the new program were positive, and they taught more science. Teachers struggled with science-as-inquiry, with a science program they believe contained too many concepts and too much vocabulary, and with their beliefs that students learned more and loved the new hands-on program. Traditional science teaching remained the norm. Administrative support was positive but insufficient to facilitate full implementation of the new program and more substantial change in teaching. Standardized science achievement test scores did not show an observable pattern of growth. It is concluded that a systematic, ongoing program of professional development is necessary to address teachers' concerns and help the district realize its goal of standards-based K-6 science instruction.

  4. Gene transfer system for Rhodopseudomonas viridis.

    PubMed Central

    Lang, F S; Oesterhelt, D

    1989-01-01

    A gene transfer system for Rhodopseudomonas viridis was established which uses conjugation with Escherichia coli S17-I as the donor and mobilizable plasmids as vectors. Initially, plasmids of the incompatibility group P1 (pRK290 and pRK404) were used. The more effective shuttle vectors between E. coli and R. viridis, pKV1 and pKVS1, were derived from plasmid pBR322 and showed the highest conjugation frequency (10(-2] thus far demonstrated in purple bacteria. It was also demonstrated that Rhizobium meliloti can be used as a donor for conjugation with R. viridis. From a genomic cosmid library of R. viridis constructed in the vector pHC79, clones that coded for subunits H (puh operon), L, M and cytochrome c (puf operon) of the photosynthetic reaction center were isolated and characterized. For linkage of the two operons on the genome, cosmids that overlapped with the operon-carrying clones were identified. The relative positions of the two operons could not be determined, but the operons must be more than 100 kilobase pairs apart. Thus, the genomic organization of the reaction center in R. viridis is different from that of Rhodobacter capsulatus, for which a distance of about 39 kilobase pairs was determined. From a spontaneous mutant of R. viridis that is resistant to the herbicide terbutryn, the puf operon was cloned in pKVS1 and transferred by conjugation into R. viridis wild-type cells. The resulting exconjugants were resistant to the herbicide, which demonstrated that the puf operon on pKVS1 constructions was functionally expressed in R. viridis. Images PMID:2666398

  5. Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma

    PubMed Central

    Noonan, Kimberly A.; Huff, Carol A.; Davis, Janice; Lemas, M. Victor; Fiorino, Susan; Bitzan, Jeffrey; Ferguson, Anna; Emerling, Amy; Luznik, Leo; Matsui, William; Powell, Jonathan; Fuchs, Ephraim; Rosner, Gary L.; Epstein, Caroline; Rudraraju, Lakshmi; Ambinder, Richard F.; Jones, Richard J.; Pardoll, Drew; Borrello, Ivan

    2015-01-01

    Successful adoptive T cell therapy (ACT) requires the ability to activate tumor-specific T cells with the ability to traffic to the tumor site and effectively kill their target as well as persist over time. We hypothesized that ACT using marrow-infiltrating lymphocytes (MILs) in multiple myeloma (MM) could impart greater antitumor immunity in that they were obtained from the tumor microenvironment. We describe the results from the first clinical trial using MILs in MM. Twenty-five patients with either newly diagnosed or relapsed disease had their MILs harvested, activated and expanded, and subsequently infused on the third day after myeloablative therapy. Cells were obtained and adequately expanded in all patients with anti-CD3/CD28 beads plus interleukin-2, and a median of 9.5 × 108 MILs were infused. Factors indicative of response to MIL ACT included (i) the presence of measurable myeloma-specific activity of the ex vivo expanded product, (ii) low endogenous bone marrow T cell interferon-γ production at baseline, (iii) a CD8+ central memory phenotype at baseline, and (iv) the generation and persistence of myeloma-specific immunity in the bone marrow at 1 year after ACT. Achieving at least a 90% reduction in disease burden significantly increased the progression-free survival (25.1 months versus 11.8 months; P = 0.01). This study demonstrates the feasibility and efficacy of MILs as a form of ACT with applicability across many hematologic malignancies and possibly solid tumors infiltrating the bone marrow. PMID:25995224

  6. Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma.

    PubMed

    Noonan, Kimberly A; Huff, Carol A; Davis, Janice; Lemas, M Victor; Fiorino, Susan; Bitzan, Jeffrey; Ferguson, Anna; Emerling, Amy; Luznik, Leo; Matsui, William; Powell, Jonathan; Fuchs, Ephraim; Rosner, Gary L; Epstein, Caroline; Rudraraju, Lakshmi; Ambinder, Richard F; Jones, Richard J; Pardoll, Drew; Borrello, Ivan

    2015-05-20

    Successful adoptive T cell therapy (ACT) requires the ability to activate tumor-specific T cells with the ability to traffic to the tumor site and effectively kill their target as well as persist over time. We hypothesized that ACT using marrow-infiltrating lymphocytes (MILs) in multiple myeloma (MM) could impart greater antitumor immunity in that they were obtained from the tumor microenvironment. We describe the results from the first clinical trial using MILs in MM. Twenty-five patients with either newly diagnosed or relapsed disease had their MILs harvested, activated and expanded, and subsequently infused on the third day after myeloablative therapy. Cells were obtained and adequately expanded in all patients with anti-CD3/CD28 beads plus interleukin-2, and a median of 9.5 × 10(8) MILs were infused. Factors indicative of response to MIL ACT included (i) the presence of measurable myeloma-specific activity of the ex vivo expanded product, (ii) low endogenous bone marrow T cell interferon-γ production at baseline, (iii) a CD8(+) central memory phenotype at baseline, and (iv) the generation and persistence of myeloma-specific immunity in the bone marrow at 1 year after ACT. Achieving at least a 90% reduction in disease burden significantly increased the progression-free survival (25.1 months versus 11.8 months; P = 0.01). This study demonstrates the feasibility and efficacy of MILs as a form of ACT with applicability across many hematologic malignancies and possibly solid tumors infiltrating the bone marrow. PMID:25995224

  7. Photoinduced Energy Transfer in Artificial Photosynthetic Systems

    NASA Astrophysics Data System (ADS)

    Imahori, H.; Umeyama, T.

    Artificial photosynthesis is a current topic of intensive investigations, both in order to understand the reactions that play a central role in natural photosynthesis as well as to develop highly efficient solar energy conversion systems and molecular optoelectronic devices [1-34]. Artificial photosynthesis is defined as a research field that attempts to mimic the natural process of photosynthesis. Therefore, the outline of natural photosynthesis is described briefly for the better understanding of artificial photosynthesis . Natural photosynthetic system is regarded as one of the most elaborate nanobiological machines [35,36]. It converts solar energy into electrochemical potential or chemical energy, which is prerequisite for the living organisms on the earth. The core function of photosynthesis is a cascade of photoinduced energy and electron transfer between donors and acceptors in the antenna complexes and the reaction center. For instance, in purple photosynthetic bacteria (Rhodopseudomonas acidophila and Rhodopseudomonas palustris) there are two different types of antenna complexes: a core light-harvesting antenna (LH1) and peripheral light-harvesting antenna (LH2) [37-39]. LH1 surrounds the reaction center where charge separation takes place.

  8. Space Biosensor Systems: Implications for Technology Transfer

    NASA Technical Reports Server (NTRS)

    Hines, J. W.; Somps, C. J.; Madou, M.; Imprescia, Clifford C. (Technical Monitor)

    1997-01-01

    To meet the need for continuous, automated monitoring of animal subjects, including; humans, during space flight, NASA is developing advanced physiologic sensor and biotelemetry system technologies. The ability to continuously track basic physiological parameters, such as heart rate, blood pH, and body temperature, in untethered subjects in space is a challenging task. At NASA's Ames Research Center, where a key focus is gravitational biology research, engineers have teamed with life scientists to develop wireless sensor systems for automated physiologic monitoring of animal models as small as the rat. This technology is also being adapted, in collaboration with medical professionals, to meet human clinical monitoring needs both in space and on the ground. Thus, these advanced monitoring technologies have important dual-use functions; they meet space flight data collection requirements and constraints, while concurrently addressing a number of monitoring and data acquisition challenges on the ground in areas of clinical monitoring and biomedical research. Additional applications for these and related technologies are being sought and additional partnerships established that enhance development efforts, reduce costs and facilitate technology infusion between the public and private sectors. This paper describes technology transfer and co-development projects that have evolved out of NASA's miniaturized, implantable chemical sensor development efforts.

  9. Enhanced local and systemic anti-melanoma CD8+ T cell responses after memory T cell-based adoptive immunotherapy in mice

    PubMed Central

    Contreras, Amanda; Sen, Siddhartha; Tatar, Andrew J.; Mahvi, David A.; Meyers, Justin V.; Srinand, Prakrithi; Suresh, Marulasiddappa

    2016-01-01

    Adoptive cell transfer (ACT) melanoma immunotherapy typically employs acutely activated effector CD8+ T cells for their ability to rapidly recognize and clear antigen. We have previously observed that effector CD8+ T cells are highly susceptible to melanoma-induced suppression, whereas memory CD8+ T cells are not. Although memory T cells have been presumed to be potentially advantageous for ACT, the kinetics of local and systemic T cell responses after effector and memory ACT have not been compared. B16F10 melanoma cells stably transfected to express very low levels of the lymphocytic choriomeningitis virus (LCMV) peptide GP33 (B16GP33) were inoculated into syngeneic C57BL/6 mice. Equal numbers of bona fide naïve, effector, or memory phenotype GP33-specific CD8+ T cells were adoptively transferred into mice 1 day after B16GP33 inoculation. The efficacy of ACT immunotherapy was kinetically assessed using serial tumor measurements and flow cytometric analyses of local and systemic CD8+ T cell responses. Control of B16GP33 tumor growth, persistence of adoptively transferred CD8+ cells, intratumoral infiltration of CD8+ T cells, and systemic CD8+ T cell responsiveness to GP33 were strongest after ACT of memory CD8+ T cells. Following surgical tumor resection and melanoma tumor challenge, only mice receiving memory T cell-based ACT immunotherapy exhibited durable tumor-specific immunity. These findings demonstrate how the use of non-expanded memory CD8+ T cells may enhance ACT immunotherapeutic efficacy. PMID:27011014

  10. Enhanced local and systemic anti-melanoma CD8+ T cell responses after memory T cell-based adoptive immunotherapy in mice.

    PubMed

    Contreras, Amanda; Sen, Siddhartha; Tatar, Andrew J; Mahvi, David A; Meyers, Justin V; Srinand, Prakrithi; Suresh, Marulasiddappa; Cho, Clifford S

    2016-05-01

    Adoptive cell transfer (ACT) melanoma immunotherapy typically employs acutely activated effector CD8+ T cells for their ability to rapidly recognize and clear antigen. We have previously observed that effector CD8+ T cells are highly susceptible to melanoma-induced suppression, whereas memory CD8+ T cells are not. Although memory T cells have been presumed to be potentially advantageous for ACT, the kinetics of local and systemic T cell responses after effector and memory ACT have not been compared. B16F10 melanoma cells stably transfected to express very low levels of the lymphocytic choriomeningitis virus (LCMV) peptide GP33 (B16GP33) were inoculated into syngeneic C57BL/6 mice. Equal numbers of bona fide naïve, effector, or memory phenotype GP33-specific CD8+ T cells were adoptively transferred into mice 1 day after B16GP33 inoculation. The efficacy of ACT immunotherapy was kinetically assessed using serial tumor measurements and flow cytometric analyses of local and systemic CD8+ T cell responses. Control of B16GP33 tumor growth, persistence of adoptively transferred CD8+ cells, intratumoral infiltration of CD8+ T cells, and systemic CD8+ T cell responsiveness to GP33 were strongest after ACT of memory CD8+ T cells. Following surgical tumor resection and melanoma tumor challenge, only mice receiving memory T cell-based ACT immunotherapy exhibited durable tumor-specific immunity. These findings demonstrate how the use of non-expanded memory CD8+ T cells may enhance ACT immunotherapeutic efficacy. PMID:27011014

  11. Correlation of natural killer cell activity and clearance of Cryptococcus neoformans from mice after adoptive transfer of splenic nylon wool-nonadherent cells.

    PubMed

    Hidore, M R; Murphy, J W

    1986-02-01

    Previous reports demonstrate that natural killer (NK) cells inhibit the growth of Cryptococcus neoformans in vitro, but conclusive evidence supporting the effectiveness of NK cells in host resistance to cryptococci is not available. The objective of these studies was to assess the ability of NK cells to clear C. neoformans from the lungs, livers, and spleens of infected mice. CBA/J mice were depleted of NK cells, as well as other natural effector cells, by an intraperitoneal injection of cyclophosphamide (Cy), 240 mg/kg of body weight. One day later, 7.5 X 10(7) nylon wool-nonadherent (NWN) spleen cells, either untreated or treated with anti-asialo GM1 and complement to remove NK cells, were adoptively transferred to Cy-pretreated mice. On day 2 after Cy treatment, the mice were injected intravenously with 2 X 10(4) cryptococci. At 4 and 6 days after Cy treatment, tissues were assayed for NK reactivity, using a 4-h 51Cr-release assay, and for in vivo clearance of cryptococci as reflected by mean log10 CFU per organ. We observed that Cy treatment depleted NK activity against YAC-1 targets and reduced in vivo clearance of C. neoformans from the tissues of infected mice. Additionally, Cy treatment depleted the total lung and spleen cellularity and the total number of peripheral blood lymphocytes when compared with those in normal untreated control mice. Also, spleen weights were significantly decreased in comparison with those of untreated animals 4 days after Cy treatment. Adoptive transfer of untreated NWN spleen cells into Cy-depressed mice restored the NK cell activity which correlated with enhanced clearance of cryptococci from lungs, livers, and spleens. In contrast, treatment of NWN spleen cells with anti-asialo GM1 and complement before adoptive transfer abrogated the ability of these cells to restore NK activity or reduce the numbers of cryptococci present in tissues of infected mice. Taken together, these data indicate that NK cells are the cells effective

  12. The measurement of water vapour transfer rate through clothing system with air gap between layers

    NASA Astrophysics Data System (ADS)

    Oh, Ae-Gyeong

    2008-02-01

    The experiments described in this paper are designed to test the water vapour transfer rates through outdoor clothing system with air gap between layers under conditions more closely actual wear. It was adopted distance of 5 mm to ensure no disturbance of the air gap thickness between layers throughout the measurement period with all fabrics. The results have indicated that the water vapour transfer rates of clothing system decrease very slightly with time, it is shown that they approached nearly equilibrium state throughout the experiment. It is revealed that the water vapour transfer rates of the clothing system were ordered into groups determined by the type of waterproof breathable fabric as a shell layer being ordered.

  13. Replacement of Cross-Site Transfer System Startup Plan

    SciTech Connect

    Gerken, M.D.

    1996-01-01

    This Startup Plan provides a discussion of organizational responsibilities, work planning, quality assurance (QA), personnel qualifications, and testing requirements for the Cross-Site Transfer System.

  14. Adoptive transfer of allergen-specific CD4+ T cells induces airway inflammation and hyperresponsiveness in brown-Norway rats.

    PubMed

    Haczku, A; Macary, P; Huang, T J; Tsukagoshi, H; Barnes, P J; Kay, A B; Kemeny, D M; Chung, K F; Moqbel, R

    1997-06-01

    Following allergen exposure, sensitized Brown-Norway rats develop airway hyperresponsiveness (AHR) and eosinophilic inflammation together with an increase in activated T cells (CD25+) in the airways. We tested the hypothesis that CD4+ T cells are involved directly in the acquisition of AHR. Spleen T cells from animals that were injected intraperitoneally on three consecutive days with ovalbumin/Al(OH)3, showed a dose-dependent proliferative response in vitro to ovalbumin, but not to bovine serum albumin, as measured by [3H]thymidine uptake. For total T-cell transfer, spleen cells obtained from donor rats 4 days after sensitization were depleted of adherent cells by a nylon wool column separation. CD4+ and CD8+ T cells were purified by immunomagnetic beads cell separation. Recipient naive rats were injected intravenously with 50 x 10(6) total T cells, 20 x 10(6) and 5 x 10(6) CD4+ cells, and 5 x 10(6) CD8+ cells, and were exposed to ovalbumin aerosol 24 hr afterwards. After a further 24 hr, airway responsiveness to acetylcholine (ACh) was measured and provocative concentration (PC) values PC100, PC200 and PC300) (the ACh concentration needed to achieve 100, 200 and 300% increase in lung resistance above baseline) were calculated. Airway responsiveness was significantly increased in recipients of sensitized total T cells compared with recipients of cells from saline-injected donor rats (P < 0.05). There were significantly increased eosinophil major basic protein (MBP)+ cell counts/mm2 in airway submucosal tissue in the hyperreactive rats and a significant correlation was found between the number of MBP+ cells and PC100 (r = 0.75; P < 0.03) in recipients of sensitized total T cells. Purified CD4+ T cells from sensitized donors induced AHR in naive recipients (P < 0.05), while sensitized CD8+ and naive CD4+ cells failed to do so. Our data indicate that T cells may induce AHR through an eosinophilic airway inflammation and that CD4+ T cells may have a direct effect in

  15. The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer

    PubMed Central

    Martin, Rebecca A.; Ather, Jennifer L.; Daggett, Rebecca; Hoyt, Laura; Alcorn, John F.; Suratt, Benjamin T.; Weiss, Daniel J.; Lundblad, Lennart K. A.; Poynter, Matthew E.

    2013-01-01

    Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO2) is an environmental toxin that correlates with asthma severity, exacerbation, and risk of adverse outcomes. Mice that are allergically sensitized to the antigen ovalbumin by exposure to NO2 exhibit a mixed Th2/Th17 adaptive immune response and eosinophil and neutrophil recruitment to the airway following antigen challenge, a phenotype reminiscent of severe clinical asthma. Because IL-1 receptor (IL-1R) signaling is critical in the generation of the Th17 response in vivo, we hypothesized that the IL-1R/Th17 axis contributes to pulmonary inflammation and airway hyperresponsiveness (AHR) in NO2-promoted allergic airway disease and manifests in glucocorticoid-resistant cytokine production. IL-17A neutralization at the time of antigen challenge or genetic deficiency in IL-1R resulted in decreased neutrophil recruitment to the airway following antigen challenge but did not protect against the development of AHR. Instead, IL-1R-/- mice developed exacerbated AHR compared to WT mice. Lung cells from NO2-allergically inflamed mice that were treated in vitro with dexamethasone (Dex) during antigen restimulation exhibited reduced Th17 cytokine production, whereas Th17 cytokine production by lung cells from recipient mice of in vitro Th17-polarized OTII T-cells was resistant to Dex. These results demonstrate that the IL-1R/Th17 axis does not contribute to AHR development in NO2-promoted allergic airway disease, that Th17 adoptive transfer does not necessarily reflect an endogenously-generated Th17 response, and that functions of Th17 responses are contingent on the experimental conditions in which they are generated. PMID:24069338

  16. An endoscopic system adopting a liquid crystal lens with an electrically tunable depth-of-field.

    PubMed

    Chen, Hung-Shan; Lin, Yi-Hsin

    2013-07-29

    Conventional endoscopic systems consisting of several solid lenses suffer from a fixed and limited depth-of-field (DOF). For practical applications, conventional endoscopes mechanically change the distance between the solid lenses of a lens module in order to change the focusing plane and DOF to see clearly in a scene. In this paper, we demonstrate an electrically tunable endoscopic system adopting a liquid crystal lens. By means of tunable focusing properties of the LC lens as a positive lens and a negative lens, the object at different objective distances can be imaged to the image sensor clearly and the corresponding depth-of-field can also help to enlarge the total spatial depth perception in a scene. The optical mechanism is discussed. In the experiments, under adjustment of three discrete lens powers of the LC lens, the viewing range or total spatial depth perception of the endoscopic system is from 76.4 mm to 12.4 mm which is 2x improved compared to the conventional one without LC lens. We believe this study can be extended to the applications of industrial and medical endoscopes. PMID:23938679

  17. C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer

    PubMed Central

    Rapp, Moritz; Grassmann, Simon; Chaloupka, Michael; Layritz, Patrick; Kruger, Stephan; Ormanns, Steffen; Rataj, Felicitas; Janssen, Klaus-Peter; Endres, Stefan; Anz, David; Kobold, Sebastian

    2016-01-01

    ABSTRACT T cell infiltration at the tumor site has been identified as a major predictor for the efficacy of adoptive T cell therapy. The chemokine C-C motif ligand 22 (CCL22) is highly expressed by immune cells in murine and human pancreatic cancer. Expression of its corresponding receptor, C-C chemokine receptor type 4 (CCR4), is restricted to regulatory T cells (Treg). We show that transduction of cytotoxic T cells (CTL) with CCR4 enhances their immigration into a pancreatic cancer model. Further, we show that binding of CCR4 with CCL22 strengthens the binding of T cell LFA-1 to dendritic cell (DC) ICAM-1 and increases CTL activation. In vivo, in a model of subcutaneous pancreatic cancer, treatment of tumor-bearing mice with CCR4-transduced CTL led to the eradication of established tumors in 40% of the mice. In conclusion, CCR4 overexpression in CTL is a promising therapeutic strategy to enhance the efficacy of adoptive T cell transfer (ACT). PMID:27195186

  18. Environment assisted energy transfer in dimer system

    SciTech Connect

    Khan, Salman; Ibrahim, M.; Khan, M.K.

    2014-02-15

    The influence of collective and multilocal environments on the energy transfer between the levels of a dimer is studied. The dynamics of energy transfer are investigated by considering coupling of collective environment with the levels of the dimer in the presence of both two individuals and mutually correlated multilocal environments. It is shown that every way of coupling we consider assists, though differently, the probability of transition between the levels of dimer. The probability of transition is strongly enhanced when the two local environments are mutually correlated. -- Highlights: • The dynamics of energy transfer between the levels of a dimer are studied. • Coupling of collective as well as individual environments are considered. • The environments are in spin star configurations. • The environment assists the energy transfer between the levels. • For correlated multilocal environments, the transition probability is almost 100%.

  19. Using System Change To Increase and Improve Adoptions: The SWAN Model.

    ERIC Educational Resources Information Center

    Jones, Martha L.

    1999-01-01

    Describes Statewide Adoption Network (SWAN) of Pennsylvania and its impact on increasing and improving quality of special-needs adoptions. Notes that program resulted from increases of children in out-of-home care, program is a public and private initiative, and that since its inception, special-needs agencies have increased, financial and…

  20. Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice.

    PubMed

    Kozlowska, Anna K; Kaur, Kawaljit; Topchyan, Paytsar; Jewett, Anahid

    2016-07-01

    Based on data obtained from oral, pancreatic and lung cancers, glioblastoma, and melanoma, we have established that natural killer (NK) cells target cancer stem-like cells (CSCs). CSCs displaying low MHC class I, CD54, and PD-L1 are killed by cytotoxic NK cells and are differentiated by split anergized NK cells through both membrane bound and secreted forms of TNF-α and IFN-γ. NK cells select and differentiate both healthy and transformed stem-like cells, resulting in target cell maturation and shaping of their microenvironment. In our recent studies, we have observed that oral, pancreatic, and melanoma CSCs were capable of forming large tumors in humanized bone marrow, liver, thymus (hu-BLT) mice with fully reconstituted human immune system. In addition, major human immune subsets including NK cells, T cells, B cells, and monocytes were present in the spleen, bone marrow, peripheral blood, and tumor microenvironment. Similar to our previously published in vitro data, CSCs differentiated with split anergized NK cells prior to implantation in mice formed smaller tumors. Intravenous injection of functionally potent osteoclast-expanded NK cells inhibited tumor growth through differentiation of CSCs in humanized mice. In this review, we present current approaches, advances, and existing limitations in studying interactions of the immune system with the tumor, in particular NK cells with CSCs, using in vivo preclinical hu-BLT mouse model. In addition, we discuss the use of osteoclast-expanded NK cells in targeting cancer stem-like tumors in humanized mice-a strategy that provides a much-needed platform to develop effective cancer immunotherapies. PMID:27034236

  1. W-314, waste transfer alternative piping system description

    SciTech Connect

    Papp, I.G.

    1998-04-30

    It is proposed that the reliability, operability, and flexibility of the Retrieval Transfer System be substantially upgraded by replacing the planned single in-farm pipeline from the AN-AY-AZ-(SY) Tank Farm Complex to the AP Farm with three parallel pipelines outside the tank farms. The proposed system provides simplified and redundant routes for the various transfer missions, and prevents the risk of transfer gridlock when the privatization effort swings into full operation.

  2. Cutaneous sensitivity induced by immunization with irradiated Schistosoma mansoni cercariae. I. Induction, elicitation, and adoptive transfer analysis of cell-mediated cutaneous sensitivity

    SciTech Connect

    Ch'ang, L.Y.; Colley, D.G.

    1986-06-01

    Exposure of C57BL/6 mice to highly irradiated (50 kR) cercariae of Schistosoma mansoni leads to the development of partial resistance against subsequent challenge with unattenuated cercariae. We have analyzed the cellular immune responses that occur during the afferent and efferent phases of this protective sensitization. Mice were immunized by exposure to irradiated S. mansoni cercariae. After challenge with irradiated cercariae, delayed-type (18-72 hr) cutaneous sensitivity reaction sites were rich in mononuclear cells and eosinophils. This reactivity was established by 4 days after sensitization, reached its maximum between 7 and 14 days after sensitization, and was maintained for over 20 weeks. These challenge reactions could be abrogated by treatment with either 200 mg/kg cyclophosphamide or 5 mg of hydrocortisone. Syngeneic adoptive transfer of cutaneous sensitivity was accomplished with lymphoid cells from the draining lymph nodes or spleens of mice sensitized 7-14 days previously. Negative selection studies of nylon-wool non-adherent cells from sensitized donors demonstrated that the cells responsible for transferring this eosinophil-rich, delayed-type cutaneous sensitivity to S. mansoni irradiated cercariae were Thy/sup -1 +/, Lyt/sup 1 +/, Lyt/sup 2 -/, surface Ig/sup -/ lymphocytes.

  3. Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner.

    PubMed

    McDonald-Hyman, Cameron; Flynn, Ryan; Panoskaltsis-Mortari, Angela; Peterson, Nicholas; MacDonald, Kelli P A; Hill, Geoffrey R; Luznik, Leo; Serody, Jonathan S; Murphy, William J; Maillard, Ivan; Munn, David H; Turka, Laurence A; Koreth, John; Cutler, Corey S; Soiffer, Robert J; Antin, Joseph H; Ritz, Jerome; Blazar, Bruce R

    2016-08-18

    Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic stem cell transplantation. In cGVHD, alloreactive T cells and germinal center (GC) B cells often participate in GC reactions to produce pathogenic antibodies. Although regulatory T cells (Tregs) can inhibit GC reactions, Treg numbers are reduced in cGVHD, contributing to cGVHD pathogenesis. Here, we explored 2 means to increase Tregs in cGVHD: interleukin-2/monoclonal antibody (IL-2/mAb) complexes and donor Treg infusions. IL-2/mAb complexes given over 1 month were efficacious in expanding Tregs and treating established cGVHD in a multi-organ-system disease mouse model characterized by GC reactions, antibody deposition, and lung dysfunction. In an acute GVHD (aGVHD) model, IL-2/mAb complexes given for only 4 days resulted in rapid mortality, indicating IL-2/mAb complexes can drive conventional T-cell (Tcon)-mediated injury. In contrast, Treg infusions, which uniformly suppress aGVHD, increased Treg frequency and were effective in preventing the onset of, and treating, established cGVHD. Efficacy was dependent upon CXCR5-sufficient Tregs homing to, and inhibiting, GC reactions. These studies indicate that the infusion of Tregs, especially ones enriched for GC homing, may be desirable for cGVHD therapy. Although IL-2/mAb complexes can be efficacious in cGVHD, a cautious approach needs to be taken in settings in which aGVHD elements, and associated Tcon, are present. PMID:27385791

  4. 40 CFR 63.689 - Standards: Transfer systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... standards specified in 40 CFR part 63, subpart RR—National Emission Standards for Individual Drain Systems... in the transfer system; the effects of outdoor exposure to wind, moisture, and sunlight; and...

  5. 40 CFR 63.689 - Standards: Transfer systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... standards specified in 40 CFR part 63, subpart RR—National Emission Standards for Individual Drain Systems... in the transfer system; the effects of outdoor exposure to wind, moisture, and sunlight; and...

  6. A Model for Instructors' Adoption of Learning Management Systems: Empirical Validation in Higher Education Context

    ERIC Educational Resources Information Center

    Findik Coskuncay, Duygu; Ozkan, Sevgi

    2013-01-01

    Through the rapid expansion of information technologies, Learning Management Systems have become one of the most important innovations for delivering education. However, successful implementation and management of these systems are primarily based on the instructors' adoption. In this context, this study aims to understand behavioral…

  7. Applying Observations from Technological Transformations in Complex Adaptive Systems to Inform Health Policy on Technology Adoption

    PubMed Central

    Phillips, Andrew B.; Merrill, Jacqueline

    2012-01-01

    Many complex markets such as banking and manufacturing have benefited significantly from technology adoption. Each of these complex markets experienced increased efficiency, quality, security, and customer involvement as a result of technology transformation in their industry. Healthcare has not benefited to the same extent. We provide initial findings from a policy analysis of complex markets and the features of these transformations that can influence health technology adoption and acceptance. PMID:24199112

  8. Applying observations from technological transformations in complex adaptive systems to inform health policy on technology adoption.

    PubMed

    Phillips, Andrew B; Merrill, Jacqueline

    2012-01-01

    Many complex markets such as banking and manufacturing have benefited significantly from technology adoption. Each of these complex markets experienced increased efficiency, quality, security, and customer involvement as a result of technology transformation in their industry. Healthcare has not benefited to the same extent. We provide initial findings from a policy analysis of complex markets and the features of these transformations that can influence health technology adoption and acceptance. PMID:24199112

  9. Assessing the Transfer Function: Tracking Down Transfer Students at Frederick Community College. A Report of the Transfer Tracking System and the Successful Transfer Survey, 1990-91.

    ERIC Educational Resources Information Center

    Holton, James M.

    During the 1990-91 academic year, Frederick Community College (FCC) in Maryland conducted a major research project to help determine the extent and effectiveness of the college's transfer function. In the study's first phase, a Transfer Tracking System (TTS) was developed by conducting a detailed audit of all transcript requests from FCC students.…

  10. Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory.

    PubMed

    Saito, Hidehito; Okita, Keisuke; Chang, Alfred E; Ito, Fumito

    2016-06-15

    Current approaches to adoptive T-cell therapy are limited by the difficulty of obtaining sufficient numbers of T cells against targeted antigens with useful in vivo characteristics. Theoretically, this limitation could be overcome by using induced pluripotent stem cells (iPSC) that could provide an unlimited source of autologous T cells. However, the therapeutic efficacy of iPSC-derived regenerated T cells remains to be demonstrated. Here, we report the first successful reprogramming of T-cell receptor (TCR) transgenic CD8(+) T cells into pluripotency. As part of the work, we established a syngeneic mouse model for evaluating in vitro and in vivo antitumor reactivity of regenerated T cells from iPSCs bearing a rearranged TCR of known antigen specificity. Stably TCR retained T-cell-derived iPSCs differentiated into CD4(+)CD8(+) T cells that expressed CD3 and the desired TCR in vitro Stimulation of iPSC-derived CD4(+)CD8(+) T cells with the cognate antigen in the presence of IL7 and IL15 followed by expansion with IL2, IL7, and IL15 generated large numbers of less-differentiated CD8(+) T cells with antigen-specific potent cytokine production and cytolytic capacity. Furthermore, adoptively transferred iPSC-derived CD8(+) T cells escaped immune rejection, mediated effective regression of large tumors, improved survival, and established antigen-specific immunological memory. Our findings illustrate the translational potential of iPSCs to provide an unlimited number of phenotypically defined, functional, and expandable autologous antigen-specific T cells with the characteristics needed to enable in vivo effectiveness. Cancer Res; 76(12); 3473-83. ©2016 AACR. PMID:27197199

  11. General Relativistic Radiative Transfer: Applications to Black-Hole Systems

    NASA Technical Reports Server (NTRS)

    Wu, Kinwah; Fuerst, Steven V.; Mizuno, Yosuke; Nishikawa, Ken-Ichi; Branduardi-Raymont, Graziella; Lee, Khee-Gan

    2007-01-01

    We present general relativistic radiation transfer formulations which include opacity effects due to absorption, emission and scattering explicitly. We consider a moment expansions for the transfer in the presence of scattering. The formulation is applied to calculation emissions from accretion and outflows in black-hole systems. Cases with thin accretion disks and accretion tori are considered. Effects, such as emission anisotropy, non-stationary flows and geometrical self-occultation are investigated. Polarisation transfer in curved space-time is discussed qualitatively.

  12. Cooperative heat transfer and ground coupled storage system

    DOEpatents

    Metz, P.D.

    A cooperative heat transfer and ground coupled storage system wherein collected solar heat energy is ground stored and permitted to radiate into the adjacent ground for storage therein over an extended period of time when such heat energy is seasonally maximally available. Thereafter, when said heat energy is seasonally minimally available and has propagated through the adjacent ground a substantial distance, the stored heat energy may be retrieved by a circumferentially arranged heat transfer means having a high rate of heat transfer.

  13. Cooperative heat transfer and ground coupled storage system

    DOEpatents

    Metz, Philip D.

    1982-01-01

    A cooperative heat transfer and ground coupled storage system wherein collected solar heat energy is ground stored and permitted to radiate into the adjacent ground for storage therein over an extended period of time when such heat energy is seasonally maximally available. Thereafter, when said heat energy is seasonally minimally available and has propagated through the adjacent ground a substantial distance, the stored heat energy may be retrieved by a circumferentially arranged heat transfer means having a high rate of heat transfer.

  14. Intimate Relationship Challenges in Early Parenthood among Lesbian, Gay, and Heterosexual Couples Adopting via the Child Welfare System

    PubMed Central

    Goldberg, Abbie E.; Kinkler, Lori A.; Moyer, April M.; Weber, Elizabeth

    2014-01-01

    Little research has examined the transition to parenthood among couples who adopt through the child welfare system. The current qualitative study of 84 individuals within 42 couples (17 lesbian, 13 gay, and 12 heterosexual), who were placed with a child via foster care three months earlier, examined perceived changes in their intimate relationship. Findings indicated that, like heterosexual biological-parent couples, some adoptive parents perceived the loss of their partner’s undivided attention as stressful to the relationship. Adoption-specific stressors were also identified, including the need to find state-approved child care to facilitate “couple time” and the legal insecurity of foster-to-adopt placements. Although our findings were similar for heterosexual, lesbian, and gay adoptive parents, same-sex couples cited some additional stressors related to their sexual minority status. Findings have implications for individual, couple, and family practitioners who work with lesbian, gay, and heterosexual adoptive parents, particularly during their transition to parenthood. PMID:25177080

  15. Effect of adopting a new histological grading system of acute rejection after heart transplantation

    PubMed Central

    Balk, A.; Zondervan, P.; van der Meer, P.; van Gelder, T.; Mochtar, B.; Simoons, M.; Weimar, W.

    1997-01-01

    Background—Treatment policy of acute rejection after heart transplantation has been changed after adopting the ISHLT endomyocardial biopsy grading system in 1991.
Objective—To determine the effect of this policy change on clinical outcome after transplantation.
Methods—The outcome of 147 patients who had a transplant before (early group, median follow up 96 months) and 114 patients who had a transplant after (late group, median follow up 41 months) the introduction of the ISHLT biopsy grading system was studied retrospectively. Initially "moderate rejection" according to Billingham's conventional criteria was treated. From January 1991 grade 3A and higher was considered to require intensification of immunosuppression.
Results—There were some differences between the two groups: recipients (50 v 44 years) as well as donors (28 v 24 years) were older in the "late group" and more patients of this group received early anti-T cell prophylaxis (92% v 56%). Despite more extensive use of early prophylaxis more rejection episodes were diagnosed (2.4 v 1.4) and considerably more courses of rejection treatment were instituted in the late compared with the early group (3.2 v 1.5). There were no deaths because of rejection in the late group, however, more infections occurred within the first year (mean 1.8 v 1.4) and more non-skin malignancies within the first 41 months were diagnosed (8 of 57 v 6 of 147, 95% CIs of difference includes 0). The incidence of graft vascular disease in the late group has been comparable to the early group until now. 
Conclusion—The interpretation of the ISHLT grading system resulted in lowering of the threshold for the diagnosis of rejection thereby increasing the number of rejections and subsequently the immunosuppressive load and its complications.

 Keywords: transplantation;  biopsy grading system;  rejection PMID:9470880

  16. BWR Core Heat Transfer Code System.

    1999-04-27

    Version 00 MOXY is used for the thermal analysis of a planar section of a boiling water reactor (BWR) fuel element during a loss-of-coolant accident (LOCA). The code emplyoys models that describe heat transfer by conduction, convection, and thermal radiation, and heat generation by metal-water reaction and fission product decay. Models are included for considering fuel-rod swelling and rupture, energy transport across the fuel-to-cladding gap, and the thermal response of the canister. MOXY requires thatmore » time-dependent data during the blowdown process for the power normalized to the steady-state power, for the heat-transfer coefficient, and for the fluid temperature be provided as input. Internal models provide these parameters during the heatup and emergency cooling phases.« less

  17. Radiation heat transfer shapefactors for combustion systems

    NASA Technical Reports Server (NTRS)

    Emery, A. F.; Johansson, O.; Abrous, A.

    1987-01-01

    The computation of radiation heat transfer through absorbing media is commonly done through the zoning method which relies upon values of the geometric mean transmittance and absorptance. The computation of these values is difficult and expensive, particularly if many spectral bands are used. This paper describes the extension of a scan line algorithm, based upon surface-surface radiation, to the computation of surface-gas and gas-gas radiation transmittances.

  18. Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma

    PubMed Central

    Aqui, Nicole A.; Stadtmauer, Edward A.; Vogl, Dan T.; Fang, Hong-Bin; Cai, Ling; Janofsky, Stephen; Chew, Anne; Storek, Jan; Akpek, Gorgun; Badros, Ashraf; Yanovich, Saul; Tan, Ming T.; Veloso, Elizabeth; Pasetti, Marcela F.; Cross, Alan; Philip, Sunita; Murphy, Heather; Bhagat, Rita; Zheng, Zhaohui; Milliron, Todd; Cotte, Julio; Cannon, Andrea; Levine, Bruce L.; Vonderheide, Robert H.; June, Carl H.

    2011-01-01

    In a phase 1/2 two-arm trial, 54 patients with myeloma received autografts followed by ex vivo anti-CD3/anti-CD28 costimulated autologous T cells at day 2 after transplantation. Study patients positive for human leukocyte antigen A2 (arm A, n = 28) also received pneumococcal conjugate vaccine immunizations before and after transplantation and a multipeptide tumor antigen vaccine derived from the human telomerase reverse transcriptase and the antiapoptotic protein survivin. Patients negative for human leukocyte antigen A2 (arm B, n = 26) received the pneumococcal conjugate vaccine only. Patients exhibited robust T-cell recoveries by day 14 with supraphysiologic T-cell counts accompanied by a sustained reduction in regulatory T cells. The median event-free survival (EFS) for all patients is 20 months (95% confidence interval, 14.6-24.7 months); the projected 3-year overall survival is 83%. A subset of patients in arm A (36%) developed immune responses to the tumor antigen vaccine by tetramer assays, but this cohort did not exhibit better EFS. Higher posttransplantation CD4+ T-cell counts and a lower percentage of FOXP3+ T cells were associated with improved EFS. Patients exhibited accelerated polyclonal immunoglobulin recovery compared with patients without T-cell transfers. Adoptive transfer of tumor antigen vaccine-primed and costimulated T cells leads to augmented and accelerated cellular and humoral immune reconstitution, including antitumor immunity, after autologous stem cell transplantation for myeloma. This study was registered at www.clinicaltrials.gov as NCT00499577. PMID:21030558

  19. The Reality of Rhetoric in Information Systems Adoption: A Case Study Investigation of the Uk National Health Service

    NASA Astrophysics Data System (ADS)

    Khan, Imran; Ferneley, Elaine

    The UK National Health Service is undergoing a tremendous IS -led change, the purpose of which is to create a service capable of meeting the demands of the 21st century. The aim of this paper is to examine the extent to which persuasive discourse, or rhetoric, influences and affects the adoption of information systems within the health sector. It seeks to explore the ways in which various actors use rhetoric to advance their own agendas and the impact this has on the system itself. As such, the paper seeks to contribute to diffusion research through the use of a case study analysis of the implementation of an Electronic Single Patient Care Record system within one UK Health Service Trust. The findings of the paper suggest that rhetoric is an important and effective persuasive tool, employed by system trainers to coax users into not only adopting the system but also using the system in a predefined manner.

  20. Policies and practices related to information system adoption in hospitals owned by Ministries of Health in the Arab Gulf.

    PubMed

    Nabali, H M

    1992-07-01

    This is a discussion paper based on the findings from a study of the factors affecting the adoption of computer-based hospital information systems (CBHIS) in the Arabian Gulf. The study involved on-site visits to hospitals in Bahrain, Kingdom of Saudi Arabia, Kuwait, Qatar and the United Arab Emirates as well as visits to ministries of health in these countries. The focus of this paper is on the adoption of CBHIS by ministry of health (MOH) hospitals, in specific, because of the main role that ministries of health play as providers of health care in the Region. Prior to describing CBHIS adoption practices, an overview of the Region in terms of its economic development and its health care delivery systems is presented. Next, the research setting along with the major findings are briefly described followed by a discussion of the advantages and disadvantages of centralized CBHIS adoptions. Finally, management guidelines related to the adoption of CBHIS by multi-hospital institutions are proposed. PMID:10120978

  1. Adoptive transfer of T cells transduced with a chimeric antigen receptor to treat relapsed or refractory acute leukemia: efficacy and feasibility of immunotherapy approaches.

    PubMed

    Ding, Guoliang; Chen, Hu

    2016-07-01

    Treatment outcomes of acute leukemia (AL) have not improved over the past several decades and relapse rates remain high despite the availability of aggressive therapies. Conventional relapsed leukemia treatment includes second allogeneic hematopoietic stem cell transplantation (allo-HSCT) and donor lymphocyte infusion (DLI), which in most cases mediate, at best, a modest graft-versus-leukemia effect, although their clinical efficacy is still limited. Although allo-HSCT following myeloablative conditioning is a curative treatment option for younger patients with acute myeloid leukemia (AML) in a first complete remission (CR), allo-HSCT as a clinical treatment is usually limited because of treatment-related toxicity. The overall DLI remission rate is only 15%-42% and 2-year overall survival (OS) is approximately 15%-20%, with a high (40%-60%) incidence of DLI-related graft-versus-host disease (GVHD). Therefore, development of new, targeted treatment strategies for relapsed and refractory AL patients is ongoing. Adoptive transfer of T cells with genetically engineered chimeric antigen receptors (CARs) is an encouraging approach for treating hematological malignancies. These T cells are capable of selectively recognizing tumor-associated antigens and may overcome many limitations of conventional therapies, inducing remission in patients with chemotherapy-refractory or relapsed AL. In this review, we aimed to highlight the current understanding of this promising treatment modality, discussing its adverse effects and efficacy. PMID:27142351

  2. 26 CFR 1.1081-6 - Transfers within system group.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 11 2011-04-01 2011-04-01 false Transfers within system group. 1.1081-6 Section... within system group. (a) The nonrecognition of gain or loss provided for in section 1081(d)(1) is...) between corporations which are all members of the same system group. The term system group is defined...

  3. 26 CFR 1.1081-6 - Transfers within system group.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Transfers within system group. 1.1081-6 Section... system group. (a) The nonrecognition of gain or loss provided for in section 1081(d)(1) is applicable to... corporations which are all members of the same system group. The term system group is defined in section...

  4. The Future Justification to Adopt Governance System at the Jordan Universities from the Perspective of Educational Experts

    ERIC Educational Resources Information Center

    Abu-Nair, Natheer Sihan

    2015-01-01

    The aim of the study was to reveal the future justification to adopt governance system at the Jordanian Universities from the perspective of educational experts. The study society was the academic staff in the field of education at Al-Balqa Applied University and Jordan University, at the first semester of the academic year 2013-2014. The study…

  5. Volatile organic compound emission rate from diffused aeration systems. 1: Mass transfer modeling

    SciTech Connect

    Chern, J.M.; Yu, C.F.

    1995-08-01

    The activated sludge process is one of the most commonly used biochemical oxidation process for the secondary treatment of municipal and industrial wastewaters. The release of volatile organic compounds (VOCs) from wastewater treatment plants has recently caused great concern. In wastewater treatment plants, many operation units such s equalization and aeration involve oxygen transfer between wastewater and air. While oxygen is transferred from air to wastewater, VOCs are stripped from wastewater to air. Due to increasingly stringent environmental regulations, wastewater treatment operators have to do VOC inventory of their facilities. A mass transfer model for VOCs is therefore called for to assess VOC emission rates from wastewater treatment processes. Almost all existing methods adopt an oxygen mass transfer model standardized by the American Society of Civil Engineers (ASCE) to evaluate VOC emission rates. A new and more fundamental oxygen mass transfer model for diffused aeration systems was developed to assess the VOC emission rates. The new model provides better insight of the VOC mass transfer process and requires only aeration performance data to predict the VOC emission rates. The results and implications of both models were discussed and compared.

  6. 77 FR 56755 - Small Business Size Standards; Adoption of 2012 North American Industry Classification System for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... rule that appeared in the Federal Register on August 20, 2012 (75 FR 49991). The document amended SBA's... Third Street SW., Washington, DC 20416. SUPPLEMENTARY INFORMATION: In FR Doc. 2012-19973 appearing on... RIN 3245-AG47 Small Business Size Standards; Adoption of 2012 North American Industry...

  7. Exploring Gender Differences in SMS-Based Mobile Library Search System Adoption

    ERIC Educational Resources Information Center

    Goh, Tiong-Thye

    2011-01-01

    This paper investigates differences in how male and female students perceived a short message service (SMS) library catalog search service when adopting it. Based on a sample of 90 students, the results suggest that there are significant differences in perceived usefulness and intention to use but no significant differences in self-efficacy and…

  8. High Quality Factor Resonators for Inductive Power Transfer Systems

    NASA Astrophysics Data System (ADS)

    Etemadrezaei, Mohammad

    In this dissertation, the Inductive Power Transfer (IPT) systems for multi-MHz frequency of operation are investigated, and new ideas for magnetic link inductive coils are presented. (Abstract shortened by ProQuest.).

  9. Modified transfer matrix method for asymmetric rotor-bearing systems

    NASA Astrophysics Data System (ADS)

    Kang, Yuan; Lee, An-Chen; Shih, Yuan-Pin

    1994-07-01

    A modified transfer matrix method (MTMM) is developed to analyze rotor-bearing systems with an asymmetric shaft and asymmetric disks. The rotating shaft is modeled by a Rayleigh-Euler beam considering the effects of the rotary inertia and gyroscopic moments. Specifically, a transfer matrix of the asymmetric shaft segments is derived in a continuous-system sense to give accurate solutions. The harmonic balance method is incorporated in the transfer matrix equations, so that steady-state responses of synchronous and superharmonic whirls can be determined. A numerical example is presented to demonstrate the effectiveness of this approach.

  10. Third-order nonlinear optical response of energy transfer systems

    NASA Astrophysics Data System (ADS)

    Yang, Mino; Fleming, Graham R.

    1999-07-01

    The third-order nonlinear optical response of energy transfer systems is theoretically investigated. A system composed of two chromophores having the same electronic transition energies is considered. The dynamics of energy transfer between the two chromophores is assumed to occur via a hopping (incoherent) mechanism. We introduce new types of pathways incorporating the hopping processes occurring while the system is in population states and reconstruct a third-order response function which is computationally viable. The nuclear propagators in the electronic population states are written as convolution integrals between those of the nonreactive two-state system weighted by some factors for the energy transfer. The response function is given by multitime correlation functions and these are analyzed by the cumulant expansion method. Based on this approach, the three-pulse photon echo peak shift for several models of energy transfer systems is discussed. It is shown that the rephasing capability of the induced signal is reduced by the memory loss due to resonant energy transfer. A previous model which incorporates resonant energy transfers in an intuitive way is reviewed and modified to supplement the loss of dynamic correlation of nuclear motion within the framework of the theory. The response function obtained by our new approach gives a more accurate description than the existing theory and a comparative discussion is given. The effect of inhomogeneity in rate constants on the third-order signal is discussed and the temperature dependence of the echo signal is examined.

  11. Solids modeller to drafting system transfer program

    SciTech Connect

    Robbins, D.

    1983-03-01

    A Solids Modeller in use at Sandia National Laboratories (Albuquerque), PADL2 has been interfaced to a Turnkey Drafting System, Applicon. This interface permits design at the high level of the Solids Modeller with dimensioning and drawing production at the turnkey drafting system.

  12. Phase I Trial of Adoptive Cell Transfer with Mixed-Profile Type-I/Type-II Allogeneic T Cells for Metastatic Breast Cancer

    PubMed Central

    Hardy, Nancy M.; Mossoba, Miriam E.; Steinberg, Seth M.; Fellowes, Vicki; Yan, Xiao-Yi; Hakim, Frances T.; Babb, Rebecca R.; Avila, Daniele; Gea-Banacloche, Juan; Sportès, Claude; Levine, Bruce L.; June, Carl H.; Khuu, Hahn M.; Carpenter, Ashley E.; Krumlauf, Michael C.; Dwyer, Andrew J.; Gress, Ronald E.; Fowler, Daniel H.; Bishop, Michael R.

    2011-01-01

    PURPOSE Metastatic breast cancer (MBC) response to allogeneic lymphocytes requires donor T-cell engraftment and is limited by graft-versus-host disease (GVHD). In mice, Type-II-polarized T cells promote engraftment and modulate GVHD whereas Type-I-polarized T cells mediate more potent graft-versus-tumor (GVT) effects. This Phase-I translational study evaluated adoptive transfer of ex-vivo-costimulated Type-I/Type-II (T1/T2) donor T cells with T-cell-depleted (TCD) allogeneic stem-cell transplantation (AlloSCT) for MBC. EXPERIMENTAL DESIGN Patients had received anthracycline, taxane and antibody therapies, been treated for metastatic disease and an HLA-identical-sibling donor. Donor lymphocytes were costimulated ex vivo with anti-CD3/anti-CD28 antibody-coated magnetic beads in IL-2/IL-4-supplemented media. Patients received reduced-intensity conditioning, donor stem cells and T1/T2 cells, and monitoring for toxicity, engraftment, GVHD and tumor response; results were compared with historical controls, identically treated except for T1/T2-product infusions. RESULTS Mixed Type-I/Type-II CD4+-T cells predominated in T1/T2 products. Nine patients received T1/T2 cells at Dose-Level 1 (5×106 cells/kg). T-cell donor chimerism reached 100% by a median of 28 days. Seven (78%) developed acute GVHD. At Day +28, five patients had partial responses (56%) and none had MBC progression; thereafter, two patients had continued responses. Donor-T-cell engraftment and tumor responses appeared faster than in historical controls, but GVHD rates were similar and responders progressed early, often following treatment of acute GVHD. CONCLUSION Allogeneic T1/T2 cells were safely infused with TCD-AlloSCT, appeared to promote donor engraftment, and may have contributed to transient early tumor responses. PMID:21948234

  13. Dendritic cells in irradiated mice trigger the functional plasticity and antitumor activity of adoptively transferred Tc17 cells via IL-12 signaling

    PubMed Central

    Bowers, Jacob S.; Nelson, Michelle H.; Kundimi, Sreenath; Bailey, Stefanie R.; Huff, Logan W.; Schwartz, Kristina M.; Cole, David J.; Rubinstein, Mark P.; Paulos, Chrystal M.

    2015-01-01

    Purpose The adoptive cell transfer (ACT) of CD8+ T cells is a promising treatment for advanced malignancies. Lymphodepletion prior to ACT enhances IFN-γ+CD8+ T cell (Tc0) mediated tumor regression. Yet, how lymphodepletion regulates the function and antitumor activity of IL-17A+CD8+ T cells (Tc17) is unknown. Experimental Design To address this question, pmel-1 CD8+ T cells were polarized to secrete either IL-17A or IFN-γ. These subsets were then infused into mice with B16F10 melanoma that were lymphoreplete (no TBI), or lymphodepleted with non-myeloablative (5 Gy) or myeloablative (9 Gy requiring hematopoietic stem cell transplantation) TBI. The activation of innate immune cells and function of donor T cell subsets was monitored in these preconditioned mice. Results Tc17 cells regress melanoma in myeloablated mice to a greater extent than in lymphoreplete or non-myeloablated mice. TBI induced functional plasticity in Tc17 cells causing conversion from IL-17A to IFN-γ producers. Additional investigation revealed that Tc17 plasticity and antitumor activity was mediated by IL-12 secreted by irradiated host dendritic cells. Neutralization of endogenous IL-12 reduced the antitumor activity of Tc17 cells in myeloablated mice, while ex vivo priming with IL-12 enhanced their capacity to regress melanoma in non-myeloablated animals. This, coupled with exogenous administration of low dose IL-12, obviated the need for host preconditioning creating curative responses in non-irradiated mice, Conclusions Our findings indicate that TBI-induced IL-12 augments Tc17 cell-mediated tumor immunity and underline the substantial implications of in vitro preparation of antitumor Tc17 cells with IL-12 in the design of T cell immunotherapies. PMID:25904754

  14. Radiative heat transfer in low-dimensional systems -- microscopic mode

    NASA Astrophysics Data System (ADS)

    Woods, Lilia; Phan, Anh; Drosdoff, David

    2013-03-01

    Radiative heat transfer between objects can increase dramatically at sub-wavelength scales. Exploring ways to modulate such transport between nano-systems is a key issue from fundamental and applied points of view. We advance the theoretical understanding of radiative heat transfer between nano-objects by introducing a microscopic model, which takes into account the individual atoms and their atomic polarizabilities. This approach is especially useful to investigate nano-objects with various geometries and give a detailed description of the heat transfer distribution. We employ this model to study the heat exchange in graphene nanoribbon/substrate systems. Our results for the distance separations, substrates, and presence of extended or localized defects enable making predictions for tailoring the radiative heat transfer at the nanoscale. Financial support from the Department of Energy under Contract No. DE-FG02-06ER46297 is acknowledged.

  15. Novel HDD-type SNDM ferroelectric data storage system aimed at high-speed data transfer with single probe operation.

    PubMed

    Hiranaga, Yoshiomi; Uda, Tomoya; Kurihashi, Yuichi; Tanaka, Kenkou; Cho, Yasuo

    2007-12-01

    In this study, several read/write tests were conducted using a novel ferroelectric data storage test system equipped with a spindle motor, targeted at high-speed data transfer using a single probe head. A periodically inverted signal can be read out correctly with a bit rate of 100 kbps using this test system, and 10 Mbps data transfer is also possible during writing operations. The effect of a dc-offset voltage applied to the writing waveform with high-speed probe scanning is discussed. In addition, a novel noncontact probe height control technique was adopted to solve the problem of tip abrasion. PMID:18276549

  16. Enhanced heat transfer in partially-saturated hydrothermal systems

    SciTech Connect

    Bixler, N.E.; Carrigan, C.R.

    1986-01-01

    The role of capillarity is potentially important for determining heat transfer in hydrothermal regions. Capillarity allows mixing of phases in liquid/vapor systems and results in enhanced two-phase convection. Comparisons involving a numerical model with capillarity and analytical models without indicate that heat transfer can be enhanced by about an order of magnitude. Whether capillarity can be important for a particular hydrothermal region will depend on the nature of mineral precipitation as well as pore and fracture size distributions.

  17. Learning Transfer--Validation of the Learning Transfer System Inventory in Portugal

    ERIC Educational Resources Information Center

    Velada, Raquel; Caetano, Antonio; Bates, Reid; Holton, Ed

    2009-01-01

    Purpose: The purpose of this paper is to analyze the construct validity of learning transfer system inventory (LTSI) for use in Portugal. Furthermore, it also aims to analyze whether LTSI dimensions differ across individual variables such as gender, age, educational level and job tenure. Design/methodology/approach: After a rigorous translation…

  18. A case study of one school system's adoption and implementation of an elementary science program

    NASA Astrophysics Data System (ADS)

    Kelly, Michael Patrick

    2000-10-01

    The researcher's purpose in this study was to examine the process used by the Minot Public Schools to adopt and implement a new elementary science program from Silver Burdett Ginn called Discovery Works. Using case study methods within a naturalistic design, the researcher investigated teachers' concerns as they adopted and implemented Discovery Works in their classrooms. Data were gathered using the Concerns Based Adoption Model (CBAM) instrument, interviews with adoption committee members, classroom teachers, grade level meetings, and document analysis of field notes related to each phase of the study. Content analysis methods were used to analyze the data. Emergent themes were presented and substantiated in the data, in terms of six research questions that guided this research. The data were analyzed both quantitatively and qualitatively to provide a rich, thick description that and enabled the researcher to confirm and triangulate the concerns of teachers in this study. The quantitative data revealed a general nonuser profile by teachers as they implemented Discovery Works. Three major themes of concerns emerged from a qualitative analysis of the data. The first theme was implementation, including issues related to teacher attitudes and inservice needs. The second theme, management issues, had five concerns subsumed within it. These included concerns related to time, materials, storage, reorder, and cooperative groups. The third theme, effects on students, included issues concerning hands-on methods of teaching science, vocabulary, especially at the upper elementary, and assessment issues. Possible solutions to resolve each of the concerns were presented. Major conclusions are that teacher concerns about Discovery Works were normal for any group experiencing a new innovation. Teachers and students enjoyed using the hands-on materials, and that Minot Public Schools has taken a small, but important step forward on the road to science education reform. Although

  19. Material transfer system in support of the plutonium immobilization program

    SciTech Connect

    Pak, D

    2000-12-20

    The Plutonium Immobilization Program requires development of the process and plant prototypic equipment to immobilize surplus plutonium in ceramic for long-term storage. Because of the hazardous nature of plutonium, it was necessary to develop a remotely operable materials transfer system which can function within the confines of a glovebox. In support of this work at LLNL, such a material transfer system (MTS) was developed. This paper presents both the mechanical and controls parts making up this system, and includes photographs of the key components and diagrams of their assemblies, as well as a description of the control sequence used to validate the MTS capabilities.

  20. Modulation transfer function technique for real time radioscopic system characterization

    SciTech Connect

    Tobin, K.W. ); Brenizer, J.S. ); Mait, J.N. )

    1989-12-01

    At the University of Virginia neutron radiography facility, a modulation transfer function technique has been developed that can easily predict and compare the resolving characteristics of the real time system and the individual system components. We desired a simple method by which new system components could be analyzed to determine their image transfer characteristics and to estimate how they would affect the composite system during data acquisition. The method employed measures a small set of constant system parameters related to data collected across a cadmium cut-edge aperture. The effects of system noise and spatial variance on the measured data are reduced so that a representation of the true signal can be obtained for analysis. Resolution parameters for the total neutron radiography system and for the individual system components are reported.

  1. Modulation transfer function technique for real time radioscopic system characterization.

    PubMed

    Tobin, K W; Brenizer, J S; Mait, J N

    1989-12-01

    At the University of Virginia neutron radiography facility, a modulation transfer function technique has been developed that can easily predict and compare the resolving characteristics of the real time system and the individual system components. We desired a simple method by which new system components could be analyzed to determine their image transfer characteristics and to estimate how they would affect the composite system during data acquisition. The method employed measures a small set of constant system parameters related to data collected across a cadmium cut-edge aperture. The effects of system noise and spatial variance on the measured data are reduced so that a representation of the true signal can be obtained for analysis. Resolution parameters for the total neutron radiography system and for the individual system components are reported. PMID:20555991

  2. Ejecta transfer in the Pluto system

    NASA Astrophysics Data System (ADS)

    Porter, Simon B.; Grundy, William M.

    2015-01-01

    The small satellites of the Pluto system (Styx, Nix, Kerberos, and Hydra) have very low surface escape velocities, and impacts should therefore eject a large amount of material from their surfaces. We show that most of this material then escapes from the Pluto system, though a significant fraction collects on the surfaces of Pluto and Charon. The velocity at which the dust is ejected from the surfaces of the small satellites strongly determines which object it is likely to hit, and where on the surfaces of Pluto and Charon it is most likely to impact. We also show that the presence of an atmosphere around Pluto eliminates most particle size effects and increases the number of dust impacts on Pluto. In total, Pluto and Charon may have accumulated several centimeters of small-satellite dust on their surfaces, which could be observed by the New Horizons spacecraft.

  3. 40 CFR 63.689 - Standards: Transfer systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... standards specified in 40 CFR part 63, subpart RR—National Emission Standards for Individual Drain Systems... transfer system is designed and operated such that an internal pressure in the vapor headspace in the enclosure is maintained at a level less than atmospheric pressure when the control device is operating,...

  4. 40 CFR 63.689 - Standards: Transfer systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... standards specified in 40 CFR part 63, subpart RR—National Emission Standards for Individual Drain Systems... transfer system is designed and operated such that an internal pressure in the vapor headspace in the enclosure is maintained at a level less than atmospheric pressure when the control device is operating,...

  5. 40 CFR 63.689 - Standards: Transfer systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... standards specified in 40 CFR part 63, subpart RR—National Emission Standards for Individual Drain Systems... transfer system is designed and operated such that an internal pressure in the vapor headspace in the enclosure is maintained at a level less than atmospheric pressure when the control device is operating,...

  6. Transfer Effects in Learning a Second Language Grammatical Gender System

    ERIC Educational Resources Information Center

    Sabourin, Laura; Stowe, Laurie A.; de Haan, Ger J.

    2006-01-01

    In this article second language (L2) knowledge of Dutch grammatical gender is investigated. Adult speakers of German, English and a Romance language (French, Italian or Spanish) were investigated to explore the role of transfer in learning the Dutch grammatical gender system. In the first language (L1) systems, German is the most similar to Dutch…

  7. A Brief History of the Transfer System in British Columbia

    ERIC Educational Resources Information Center

    Gaber, Devron

    2005-01-01

    This document presents a brief history of important events in the development and maintenance of the post-secondary transfer system in British Columbia (BC) over the last six decades. Information is presented in point form and in chronological order. Several points related to the expansion of the post-secondary system are included, and hence the…

  8. Operational test report for 2706-T complex liquid transfer system

    SciTech Connect

    BENZEL, H.R.

    1999-09-01

    This document is the Operational Test Report (OTR). It enters the Record Copy of the W-259 Operational Test Procedure (HNF-3610) into the document retrieval system. Additionally, the OTR summarizes significant issues associated with testing the 2706-T waste liquid transfer and storage system.

  9. Human transfer functions used to predict system performance parameters

    NASA Technical Reports Server (NTRS)

    1966-01-01

    Automatic, parameter-tracking, model-matching technique compares the responses of a human operator with those of an analog computer model of a human operator to predict and analyze the performance of mechanical or electromechanical systems prior to construction. Transfer functions represent the input-output relation of an operator controlling a closed-loop system.

  10. [Contrast transfer function of the visual system].

    PubMed

    Pak, M A; Cleveland, S J

    1991-09-01

    Visually evoked potentials were used to determine the spatial contrast response function of the visual system and the visual acuity of the pigeon. The spatial contrast response describes the relationship between the contrast in a pattern of vertical stripes, whose luminance is a function of position, and the amplitude of the visually evoked response at various spatial frequencies for a given temporal frequency (pattern reversal frequency); it indicates how particular spatial frequencies are attenuated in the visual system. The visually evoked responses were recorded using monopolar stainless steel electrodes inserted into the stratum griseum superficiale of the optic tectum; the depth of penetration was determined on the basis of a stereotactic atlas. The stimulus patterns were generated on a video monitor placed 75 cm in front of the animal's eye perpendicular to the optic axis. The spatial contrast response function measured at 10% contrast and 0.5 Hz reversal frequency shows a peak at a spatial frequency of 0.5 c/deg, corresponding to 1 degree of visual angle, and decreases progressively at higher spatial frequencies. The high-frequency limit (cut-off frequency) for resolution of sinusoidal gratings, estimated from the contrast response function, is 15.5 c/deg, corresponding to a visual acuity of 1.9 min of arc. PMID:1657228

  11. Advanced two-phase heat transfer systems

    NASA Technical Reports Server (NTRS)

    Swanson, Theodore D.

    1992-01-01

    Future large spacecraft, such as the Earth Observing System (EOS) platforms, will require a significantly more capable thermal control system than is possible with current 'passive' technology. Temperatures must be controlled much more tightly over a larger surface area. Numerous heat load sources will often be located inside the body of the spacecraft without a good view to space. Power levels and flux densities may be higher than can be accommodated with traditional technology. Integration and ground testing will almost certainly be much more difficult with such larger, more complex spacecraft. For these and similar reasons, the Goddard Space Flight Center (GSFC) has been developing a new, more capable thermal control technology called capillary pumped loops (CPL's). CPL's represent an evolutionary improvement over heat pipes; they can transport much greater quantities of heat over much longer distances and can serve numerous heat load sources. In addition, CPL's can be fabricated into large cold plates that can be held to tight thermal gradients. Development of this technology began in the early 1980's and is now reaching maturity. CPL's have recently been baselined for the EOS-AM platform (1997 launch) and the COMET spacecraft (1992 launch). This presentation describes this new technology and its applications. Most of the viewgraphs are self descriptive. For those that are less clear additional comments are provided.

  12. Issues Pertaining to the Transfer Function of the California Community Colleges: A Report Adopted by the Executive Committee of the Academic Senate for California Community Colleges.

    ERIC Educational Resources Information Center

    Villa, Maryamber

    Designed as a formal response to the Report of the Task Group on Retention and Transfer (HE 014 825), by Gerald Kissler, which is sharply critical of the community college transfer program, this report examines issues related to the transfer of community college students to the University of California (UC) and the California State Universities…

  13. Radiative transfer in atmosphere-sea ice-ocean system

    SciTech Connect

    Jin, Z.; Stamnes, K.; Weeks, W.F.; Tsay, S.C.

    1996-04-01

    Radiative energy is critical in controlling the heat and mass balance of sea ice, which significantly affects the polar climate. In the polar oceans, light transmission through the atmosphere and sea ice is essential to the growth of plankton and algae and, consequently, to the microbial community both in the ice and in the ocean. Therefore, the study of radiative transfer in the polar atmosphere, sea ice, and ocean system is of particular importance. Lacking a properly coupled radiative transfer model for the atmosphere-sea ice-ocean system, a consistent study of the radiative transfer in the polar atmosphere, snow, sea ice, and ocean system has not been undertaken before. The radiative transfer processes in the atmosphere and in the ice and ocean have been treated separately. Because the radiation processes in the atmosphere, sea ice, and ocean depend on each other, this separate treatment is inconsistent. To study the radiative interaction between the atmosphere, clouds, snow, sea ice, and ocean, a radiative transfer model with consistent treatment of radiation in the coupled system is needed and is under development.

  14. Methods for Gene Transfer to the Central Nervous System

    PubMed Central

    Kantor, Boris; Bailey, Rachel M.; Wimberly, Keon; Kalburgi, Sahana N.; Gray, Steven J.

    2015-01-01

    Gene transfer is an increasingly utilized approach for research and clinical applications involving the central nervous system (CNS). Vectors for gene transfer can be as simple as an unmodified plasmid, but more commonly involve complex modifications to viruses to make them suitable gene delivery vehicles. This chapter will explain how tools for CNS gene transfer have been derived from naturally occurring viruses. The current capabilities of plasmid, retroviral, adeno-associated virus, adenovirus, and herpes simplex virus vectors for CNS gene delivery will be described. These include both focal and global CNS gene transfer strategies, with short- or long-term gene expression. As is described in this chapter, an important aspect of any vector is the cis-acting regulatory elements incorporated into the vector genome that control when, where, and how the transgene is expressed. PMID:25311922

  15. Optimized transfer trajectories in the earth-moon system

    NASA Astrophysics Data System (ADS)

    Xie, Wen-Xian; Xu, Wei; Cai, Li

    2008-01-01

    Investigations of low energy transfer trajectories are important for both celestial mechanics and astronautics. Methodologies using the theories from dynamical systems are developed in recent years. This paper investigates the dynamics of the earth-moon system. Low energy transfer trajectories are solved numerically by employing a hybrid strategy: first, a genetic hide and seek method performs a search in large domain to confine the global minimum f(η) (objective function) region; then, a deterministic Nelder Mead method is utilized to refine the minimum quickly. Some transfer trajectories of the spacecraft in the earth-moon system are successfully simulated which verify the desired efficiency and robustness of the method of this paper.

  16. Transferability and data access issues. [decision information display system

    NASA Technical Reports Server (NTRS)

    Ferreros, A. V.

    1981-01-01

    The evolution and current operational mode of the domestic information display system (DIDS) now known as the decision information display system are described. This minicomputer based system, developed from a NASA-generated image processing system, was designed to display federal statistical data for a variety of geographic areas in the form of choropleth maps. The application of DIDS in South Carolina is discussed as well as the progress made and issues that emerged in using the data base on a state and county level. The hardware base for the system, how this user friendly system works, and the possibility of transferring data to remote systems are examined.

  17. Method of measuring heat influx of a cryogenic transfer system

    DOEpatents

    Niemann, Ralph C.; Zelipsky, Steven A.; Rezmer, Ronald R.; Smelser, Peter

    1981-01-01

    A method is provided for measuring the heat influx of a cryogenic transfer system. A gaseous phase of the cryogen used during normal operation of the system is passed through the system. The gaseous cryogen at the inlet to the system is tempered to duplicate the normal operating temperature of the system inlet. The temperature and mass flow rate of the gaseous cryogen is measured at the outlet of the system, and the heat capacity of the cryogen is determined. The heat influx of the system is then determined from known thermodynamic relationships.

  18. Superfinished Surfaces for Power Transfer Systems Improvement

    NASA Technical Reports Server (NTRS)

    Niskanen, Paul; Manesh, Ali; Warren, Alford; Krantz, Timothy

    2002-01-01

    The continuous demands for high performance and lightweight power train systems resulted in requirements for higher power density gearing systems. However, increasing the load bearing capacity of the gear teeth, without increasing size, places stringent requirements upon metallurgy, dimensional control, and surface finish of the final products. In order to operate the mating parts near the upper bounds of their theoretical design envelope, manufacturing processes are required that are capable of improving the fatigue life and load bearing capacity of precision parts, while producing the required geometric accuracy. Results of the recent experimental studies indicate that the super finishing process is able to achieve these goals. This paper will review the results of our continuing evaluation of the super finish process as applied to aerospace gearing. Two separate evaluations were performed on gears to examine the effects of super finishing on resistance to both pitting and contact fatigue. For the reported experiments, both conventional and super finished test gears were simultaneously manufactured using the same process and the same heat lot of materials. This paper will also provide a brief description of the manufacturing technology used to achieve the results and will compare the results with other published data. In addition, this paper presents a couple of off-the-shelf manufacturing technologies that have been successfully used to super finish test specimens and will provide a glimpse of other emerging super finishing technologies. This is a US Army Manufacturing Technology project. The project was sponsored by the Aviation and Missiles Command (AMCOM) and was being managed and conducted by IIT Research Institute.

  19. Autocorrelation method for measuring the transfer function of optical systems

    NASA Astrophysics Data System (ADS)

    Grover, C. P.; van Driel, H. M.

    1980-03-01

    An unconventional autocorrelation method is described for measuring the transfer function of optical systems. The interference takes place between the scattered waves obtained from two laterally sheared correlated partial diffusers. The output of a detector responding only to an extremely narrowband of spatial frequencies is proportional to the autocorrelation of the system pupil function. An automatic display of the transfer function is obtained by continuously varying the shear between the diffusers. The theory and some experimental results of this simple and inexpensive device are presented. A study of various parameters affecting the performance of the instrument is also given.

  20. Heat and mass transfer considerations in advanced heat pump systems

    SciTech Connect

    Panchal, C.B.; Bell, K.J.

    1992-01-01

    Advanced heat-pump cycles are being investigated for various applications. However, the working media and associated thermal design aspects require new concepts for maintaining high thermal effectiveness and phase equilibrium for achieving maximum possible thermodynamic advantages. In the present study, the heat- and mass-transfer processes in two heat-pump systems -- those based on absorption processes, and those using refrigerant mixtures -- are analyzed. The major technical barriers for achieving the ideal performance predicted by thermodynamic analysis are identified. The analysis provides general guidelines for the development of heat- and mass-transfer equipment for advanced heat-pump systems.

  1. Heat and mass transfer considerations in advanced heat pump systems

    SciTech Connect

    Panchal, C.B.; Bell, K.J.

    1992-08-01

    Advanced heat-pump cycles are being investigated for various applications. However, the working media and associated thermal design aspects require new concepts for maintaining high thermal effectiveness and phase equilibrium for achieving maximum possible thermodynamic advantages. In the present study, the heat- and mass-transfer processes in two heat-pump systems -- those based on absorption processes, and those using refrigerant mixtures -- are analyzed. The major technical barriers for achieving the ideal performance predicted by thermodynamic analysis are identified. The analysis provides general guidelines for the development of heat- and mass-transfer equipment for advanced heat-pump systems.

  2. Organization-wide adoption of computerized provider order entry systems: a study based on diffusion of innovations theory

    PubMed Central

    2009-01-01

    Background Computerized provider order entry (CPOE) systems have been introduced to reduce medication errors, increase safety, improve work-flow efficiency, and increase medical service quality at the moment of prescription. Making the impact of CPOE systems more observable may facilitate their adoption by users. We set out to examine factors associated with the adoption of a CPOE system for inter-organizational and intra-organizational care. Methods The diffusion of innovation theory was used to understand physicians' and nurses' attitudes and thoughts about implementation and use of the CPOE system. Two online survey questionnaires were distributed to all physicians and nurses using a CPOE system in county-wide healthcare organizations. The number of complete questionnaires analyzed was 134 from 200 nurses (67.0%) and 176 from 741 physicians (23.8%). Data were analyzed using descriptive-analytical statistical methods. Results More nurses (56.7%) than physicians (31.3%) stated that the CPOE system introduction had worked well in their clinical setting (P < 0.001). Similarly, more physicians (73.9%) than nurses (50.7%) reported that they found the system not adapted to their specific professional practice (P = < 0.001). Also more physicians (25.0%) than nurses (13.4%) stated that they did want to return to the previous system (P = 0.041). We found that in particular the received relative advantages of the CPOE system were estimated to be significantly (P < 0.001) higher among nurses (39.6%) than physicians (16.5%). However, physicians' agreements with the compatibility of the CPOE and with its complexity were significantly higher than the nurses (P < 0.001). Conclusions Qualifications for CPOE adoption as defined by three attributes of diffusion of innovation theory were not satisfied in the study setting. CPOE systems are introduced as a response to the present limitations in paper-based systems. In consequence, user expectations are often high on their relative

  3. Control Decisions for Flammable Gas Hazards in Waste Transfer Systems

    SciTech Connect

    KRIPPS, L.J.

    2000-06-28

    This report describes the control decisions for flammable gas hazards in waste transfer systems (i.e., waste transfer piping and waste transfer-associated structures) made at control decision meetings on November 30, 1999a and April 19, 2000, and their basis. These control decisions, and the analyses that support them, will be documented in an amendment to the Final Safety Analysis Report (FSAR) (CHG 2000a) and Technical Safety Requirements (TSR) (CHG 2000b) to close the Flammable Gas Unreviewed Safety Question (USQ) (Bacon 1996 and Wagoner 1996). Following the Contractor Tier I review of the FSAR and TSR amendment, it will be submitted to the US. Department of Energy (DOE), Office of River Protection (ORP) for review and approval. The control decision meeting on November 30, 1999 to address flammable gas hazards in waste transfer systems followed the control decision process and the criteria for control decisions described in Section 3.3.1.5 of the FSAR. The control decision meeting agenda, attendance list, and introductory and background presentations are included in Attachments 1 through 4. The control decision discussions on existing and other possible controls for flammable gas hazards in waste transfer systems and the basis for selecting or not selecting specific controls are summarized in this report.

  4. [The model of state health policy and the system of medical assistance adopted in present-day Brazil].

    PubMed

    Queiroz, M de S; Vianna, A L

    1992-04-01

    A contribution to the analysis of the health reform presently occurring in Brazil is presented. The need to consolidate the theoretical background which supports the advances already achieved in order to understand recent events in the area is stressed. In this regard, the health reform is understood as a question transcending the mere administrative and managerial aspect of the health system, since it necessarily involves a redefinition of the concepts of health, disease and the medical practice adopted by the dominant mechanistic paradigm of medicine. The recent events which delineate the health system in Brazil are analysed and criticised in the light of this concern. PMID:1307428

  5. Quantum electrodynamics of resonance energy transfer in nanowire systems

    NASA Astrophysics Data System (ADS)

    Weeraddana, Dilusha; Premaratne, Malin; Andrews, David L.

    2016-02-01

    Nonradiative resonance energy transfer (RET) provides the ability to transfer excitation energy between contiguous nanowires (NWs) with high efficiency under certain conditions. Nevertheless, the well-established Förster formalism commonly used to represent RET was developed for energy transfer primarily between molecular blocks (i.e., from one molecule, or part of a molecule, to another). Although deviations from Förster theory for functional blocks such as NWs have been studied previously, the role of the relative distance, the orientation of transition dipole moment pairs, and the passively interacting matter on electronic energy transfer are to a large extent unknown. Thus, a comprehensive theory that models RET in NWs is required. In this context, analytical insights to give a deeper and more intuitive understanding of the distance and orientation dependence of RET in NWs is presented within the framework of quantum electrodynamics. Additionally, the influence of an included intermediary on the rate of excitation energy transfer is illustrated, embracing indirect energy transfer rate and quantum interference. The results deliver equations that afford new intuitions into the behavior of virtual photons. In particular, results indicate that RET efficiency in a NW system can be explicitly expedited or inhibited by a neighboring mediator, depending on the relative spacing and orientation of NWs.

  6. Optimal Energy Transfer in Light-Harvesting Systems.

    PubMed

    Chen, Lipeng; Shenai, Prathamesh; Zheng, Fulu; Somoza, Alejandro; Zhao, Yang

    2015-01-01

    Photosynthesis is one of the most essential biological processes in which specialized pigment-protein complexes absorb solar photons, and with a remarkably high efficiency, guide the photo-induced excitation energy toward the reaction center to subsequently trigger its conversion to chemical energy. In this work, we review the principles of optimal energy transfer in various natural and artificial light harvesting systems. We begin by presenting the guiding principles for optimizing the energy transfer efficiency in systems connected to dissipative environments, with particular attention paid to the potential role of quantum coherence in light harvesting systems. We will comment briefly on photo-protective mechanisms in natural systems that ensure optimal functionality under varying ambient conditions. For completeness, we will also present an overview of the charge separation and electron transfer pathways in reaction centers. Finally, recent theoretical and experimental progress on excitation energy transfer, charge separation, and charge transport in artificial light harvesting systems is delineated, with organic solar cells taken as prime examples. PMID:26307957

  7. Air-ground information transfer in the National Airspace System

    NASA Technical Reports Server (NTRS)

    Lee, Alfred T.; Lozito, Sandra

    1989-01-01

    This paper reviews NASA's Aviation Safety Reporting System incident data for a two-year period in order to identify the frequency of air-ground information transfer errors and the factors associated with their occurrence. Of the more than 14,000 primary reports received during the 1985 and 1986 reporting period, one out of four reports concerned problems of information transfer between aircraft and ATC. Approximately half of these errors were associated directly or indirectly with aircraft deviations from assigned heading or altitude. The majority of incidents cited some human-system problem such as workload, cockpit distractions, etc., as the primary contributing factor. Improvements in air-ground information transfer using existing and future (e.g., data link) technology are proposed centering on the development and application of user-centered information management principles.

  8. Dynamics of entanglement transfer through multipartite dissipative systems

    SciTech Connect

    Lopez, C. E.; Retamal, J. C.; Romero, G.

    2010-06-15

    We study the dynamics of entanglement transfer in a system composed of two initially correlated three-level atoms, each located in a cavity interacting with its own reservoir. Instead of tracing out reservoir modes to describe the dynamics using the master equation approach, we consider explicitly the dynamics of the reservoirs. In this situation, we show that the entanglement is completely transferred from atoms to reservoirs. Although the cavities mediate this entanglement transfer, we show that under certain conditions, no entanglement is found in cavities throughout the dynamics. Considering the entanglement dynamics of interacting and noninteracting bipartite subsystems, we found time windows where the entanglement can only flow through interacting subsystems, depending on the system parameters.

  9. Fernald vacuum transfer system for uranium materials repackaging

    SciTech Connect

    Kaushiva, Shirley; Weekley, Clint; Molecke, Martin; Polansky, Gary

    2002-02-24

    The Fernald Environmental Management Project (FEMP) is the site of a former Department of Energy (DOE) uranium processing plant. When production was halted, many materials were left in an intermediate state. Some of this product material included enriched uranium compounds that had to be repackaged for shipment of off-site storage. This paper provides an overview, technical description, and status of a new application of existing technology, a vacuum transfer system, to repackage the uranium bearing compounds for shipment. The vacuum transfer system provides a method of transferring compounds from their current storage configuration into packages that meet the Department of Transportation (DOT) shipping requirements for fissile materials. This is a necessary activity, supporting removal of nuclear materials prior to site decontamination and decommissioning, key to the Fernald site's closure process.

  10. Adoptive cell transfer of contact sensitivity-initiation mediated by nonimmune cells sensitized with monoclonal IgE antibodies. Dependence on host skin mast cells.

    PubMed

    Matsuda, H; Ushio, H; Paliwal, V; Ptak, W; Askenase, P W

    1995-05-15

    A role for mast cell release of serotonin (5-HT), via Ag-specific factors derived from Thy-1+ B220+ lymphoid cells in the initiation of murine contact sensitivity (CS) has been suggested. However, because CS in mast cell-deficient mice was intact, a role for mast cells in CS initiation was unclear. Therefore, we examined whether CS could be initiated by i.v. injection of nonimmune mixed lymphoid cells that were sensitized in vitro with IgE. When naive mice received IgE-sensitized nonimmune spleen or lymph node cells, or IgE-sensitized purified mast cells, together with immune CS-effector B220- T cells, which therefore were depleted of CS-initiating, Thy-1+, B220+ cells, which could not transfer CS, then reconstitution of CS occurred. Mast cell-deficient W/Wv mice could not elicit this IgE-dependent CS ear swelling, but when mast cell deficiency was reversed by ear injection of normal bone marrow-derived cultured mast cells, then CS was restored. In vitro pretreatment with irrelevant monoclonal anti-OVA IgE prevented CS initiation mediated by Ag-specific, IgE mAb-sensitized cells, presumably by blocking sensitization with IgE. Thus Fc epsilon R on the normal lymphoid cells were involved. When ketanserin, a 5-HT2 receptor antagonist, was injected i.v. before cell transfer, CS initiation via IgE-sensitized cells and CS were no longer elicited. Thus, in this system, IgE Abs bound to circulating IgE Fc epsilon R bearing lymphoid cells sensitized in vitro (most likely basophils), probably mediated early activation of these circulating basophils to release mediators, causing 5-HT release from cutaneous mast cells, to mediate CS initiation. PMID:7730614

  11. Flow and heat transfer in rotating-disc systems. Volume I - Rotor-stator systems

    NASA Astrophysics Data System (ADS)

    Owen, J. M.; Roger, R. H.

    The rotating flows occurring inside turbomachinery are discussed. Laminar and turbulent flow over a single disk and heat transfer from a single disk are addressed. Rotor-stator systems with and without superposed flow, heat transfer in rotor-stator systems, and the ingress problem of sealing rotor-stator systems are examined.

  12. Automatic graphene transfer system for improved material quality and efficiency

    PubMed Central

    Boscá, Alberto; Pedrós, Jorge; Martínez, Javier; Palacios, Tomás; Calle, Fernando

    2016-01-01

    In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible substrates but tend to induce mechanical damage in rigid ones. A new system that automatically transfers CVD graphene to an arbitrary target substrate has been developed. The process is based on the all-fluidic manipulation of the graphene to avoid mechanical damage, strain and contamination, and on the combination of capillary action and electrostatic repulsion between the graphene and its container to ensure a centered sample on top of the target substrate. The improved carrier mobility and yield of the automatically transferred graphene, as compared to that manually transferred, is demonstrated by the optical and electrical characterization of field-effect transistors fabricated on both materials. In particular, 70% higher mobility values, with a 30% decrease in the unintentional doping and a 10% strain reduction are achieved. The system has been developed for lab-scale transfer and proved to be scalable for industrial applications. PMID:26860260

  13. Automatic graphene transfer system for improved material quality and efficiency

    NASA Astrophysics Data System (ADS)

    Boscá, Alberto; Pedrós, Jorge; Martínez, Javier; Palacios, Tomás; Calle, Fernando

    2016-02-01

    In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible substrates but tend to induce mechanical damage in rigid ones. A new system that automatically transfers CVD graphene to an arbitrary target substrate has been developed. The process is based on the all-fluidic manipulation of the graphene to avoid mechanical damage, strain and contamination, and on the combination of capillary action and electrostatic repulsion between the graphene and its container to ensure a centered sample on top of the target substrate. The improved carrier mobility and yield of the automatically transferred graphene, as compared to that manually transferred, is demonstrated by the optical and electrical characterization of field-effect transistors fabricated on both materials. In particular, 70% higher mobility values, with a 30% decrease in the unintentional doping and a 10% strain reduction are achieved. The system has been developed for lab-scale transfer and proved to be scalable for industrial applications.

  14. Automatic graphene transfer system for improved material quality and efficiency.

    PubMed

    Boscá, Alberto; Pedrós, Jorge; Martínez, Javier; Palacios, Tomás; Calle, Fernando

    2016-01-01

    In most applications based on chemical vapor deposition (CVD) graphene, the transfer from the growth to the target substrate is a critical step for the final device performance. Manual procedures are time consuming and depend on handling skills, whereas existing automatic roll-to-roll methods work well for flexible substrates but tend to induce mechanical damage in rigid ones. A new system that automatically transfers CVD graphene to an arbitrary target substrate has been developed. The process is based on the all-fluidic manipulation of the graphene to avoid mechanical damage, strain and contamination, and on the combination of capillary action and electrostatic repulsion between the graphene and its container to ensure a centered sample on top of the target substrate. The improved carrier mobility and yield of the automatically transferred graphene, as compared to that manually transferred, is demonstrated by the optical and electrical characterization of field-effect transistors fabricated on both materials. In particular, 70% higher mobility values, with a 30% decrease in the unintentional doping and a 10% strain reduction are achieved. The system has been developed for lab-scale transfer and proved to be scalable for industrial applications. PMID:26860260

  15. Production and Transfer of Energy and Information in Hamiltonian Systems

    PubMed Central

    Antonopoulos, Chris G.; Bianco-Martinez, Ezequiel; Baptista, Murilo S.

    2014-01-01

    We present novel results that relate energy and information transfer with sensitivity to initial conditions in chaotic multi-dimensional Hamiltonian systems. We show the relation among Kolmogorov-Sinai entropy, Lyapunov exponents, and upper bounds for the Mutual Information Rate calculated in the Hamiltonian phase space and on bi-dimensional subspaces. Our main result is that the net amount of transfer from kinetic to potential energy per unit of time is a power-law of the upper bound for the Mutual Information Rate between kinetic and potential energies, and also a power-law of the Kolmogorov-Sinai entropy. Therefore, transfer of energy is related with both transfer and production of information. However, the power-law nature of this relation means that a small increment of energy transferred leads to a relatively much larger increase of the information exchanged. Then, we propose an “experimental” implementation of a 1-dimensional communication channel based on a Hamiltonian system, and calculate the actual rate with which information is exchanged between the first and last particle of the channel. Finally, a relation between our results and important quantities of thermodynamics is presented. PMID:24586891

  16. Information transfer by leaky, heterogeneous, protein kinase signaling systems

    PubMed Central

    Voliotis, Margaritis; Perrett, Rebecca M.; McWilliams, Chris; McArdle, Craig A.; Bowsher, Clive G.

    2014-01-01

    Cells must sense extracellular signals and transfer the information contained about their environment reliably to make appropriate decisions. To perform these tasks, cells use signal transduction networks that are subject to various sources of noise. Here, we study the effects on information transfer of two particular types of noise: basal (leaky) network activity and cell-to-cell variability in the componentry of the network. Basal activity is the propensity for activation of the network output in the absence of the signal of interest. We show, using theoretical models of protein kinase signaling, that the combined effect of the two types of noise makes information transfer by such networks highly vulnerable to the loss of negative feedback. In an experimental study of ERK signaling by single cells with heterogeneous ERK expression levels, we verify our theoretical prediction: In the presence of basal network activity, negative feedback substantially increases information transfer to the nucleus by both preventing a near-flat average response curve and reducing sensitivity to variation in substrate expression levels. The interplay between basal network activity, heterogeneity in network componentry, and feedback is thus critical for the effectiveness of protein kinase signaling. Basal activity is widespread in signaling systems under physiological conditions, has phenotypic consequences, and is often raised in disease. Our results reveal an important role for negative feedback mechanisms in protecting the information transfer function of saturable, heterogeneous cell signaling systems from basal activity. PMID:24395805

  17. An Introduction to Register Transfer Level Simulation of Digital Systems.

    ERIC Educational Resources Information Center

    Hemming, Cliff; Smith R. J., II

    Register transfer level (RTL) descriptions of digital systems have certain advantages over other descriptive techniques, especially during early phases of the design effort. There are at least three identifiable major uses for RTL-type descriptions. First, RTL can serve as documentation of digital processor behavior, recording in a concise fashion…

  18. West Valley transfer cart control system design description

    SciTech Connect

    Bradley, E.C.; Crutcher, R.I.; Halliwell, J.W.; Hileman, M.S.; Moore, M.R.; Nodine, R.N.; Ruppel, F.R.; Vandermolen, R.I.

    1993-01-01

    Detail design of the control system for the West Valley Nuclear Services Vitrification Facility transfer cart has been completed by Oak Ridge National Laboratory. This report documents the requirements and describes the detail design of that equipment and control software. Copies of significant design documents including analysis and testing reports and design drawings are included in the Appendixes.

  19. Transfer of Instrument Training and the Synthetic Flight Training System.

    ERIC Educational Resources Information Center

    Caro, Paul W.

    One phase of an innovative flight training program, its development, and initial administration is described in this paper. The operational suitability test activities related to a determination of the transfer of instrument training value of the Army's Synthetic Flight Training System (SFTS) Device 2B24. Sixteen active Army members of an Officer…

  20. Migrant Student Record Transfer System in New York State.

    ERIC Educational Resources Information Center

    New York State Education Dept., Albany. Bureau of Migrant Education.

    In 1970, the Migrant Student Record Transfer System (MSRTS) was funded through Title I of the Elementary and Secondary Education Act. A single center at Little Rock (Arkansas) was designed to contain a profile on each migrant student enrolled. The Center's aim was to assure a high degree of accuracy while maintaining flexibility and ready access…

  1. Information Systems and Networks for Technology Transfer. Final Report.

    ERIC Educational Resources Information Center

    Page, John; Szentivanyi, Tibor

    Results of a survey of the information resources available in industrialized countries which might be used in a United Nations technology transfer program for developing countries are presented. Information systems and networks, organized information collections of a scientific and technical character, and the machinery used to disseminate this…

  2. The Uniform Migrant Student Record Transfer System. A Position Paper.

    ERIC Educational Resources Information Center

    National Committee on the Education of Migrant Children, New York, NY.

    Initiated in the mid-sixties under Title I of the Elementary and Secondary Education Act, the Uniform Migrant Student Record Transfer System (UMSRTS) was designed to maintain ready accessibility via computer data base to the health and academic records of migrant children. The National Committee on the Education of Migrant Children (NCEMC)…

  3. Putting Dreyfus into Action: The European Credit Transfer System

    ERIC Educational Resources Information Center

    Markowitsch, Jorg; Luomi-Messerer, Karin; Becker, Matthias; Spottl, Georg

    2008-01-01

    Purpose: The purpose of this article is to look closely at the development of a European Credit Transfer System for Vocational Education and Training (ECVET). The European Commission, together with the member States, are working on it and several pilot projects have been initiated within the Leonardo da Vinci Programme of the European Commission.…

  4. "When You're Sitting on the Fence, Hope's the Hardest Part": Challenges and Experiences of Heterosexual and Same-Sex Couples Adopting Through the Child Welfare System.

    PubMed

    Goldberg, Abbie; Moyer, April M; Kinkler, Lori A; Richardson, Hannah B

    2012-01-01

    Foster-to-adopt families can be viewed as systems that are influenced by many other systems (e.g., the legal system, the social service agency, and the birth family). The current qualitative study of 84 foster-to-adopt parents (members of 42 lesbian, gay, and heterosexual couples) examined the types of challenges that parents faced as they navigated multiple systems during the initial post-placement period. Some participants described the legal insecurity associated with their role as foster-to-adopt parents as impacting their personal well-being and their attachment to their children. Lack of support services and disorganization within social service agencies, as well as strained relationships with birth parents, were also identified as stressors for foster-to-adopt parents. Importantly, lesbian and gay participants faced additional concerns regarding the security of their placement, due to the possibility for discrimination within the various systems involved with the foster-to-adopt process. Participants as a whole also identified positive aspects of their experiences within various systems; for example, they appreciated child care subsidies, state-provided health insurance, and supportive social workers. Our findings provide insights into foster-to-adopt parents' experiences during the initial post-placement period, and have implications for adoption services aimed to improve placement stability and enhance family functioning in foster-to-adopt families. PMID:23226935

  5. EHR adopters vs. non-adopters: Impacts of, barriers to, and federal initiatives for EHR adoption

    PubMed Central

    Jamoom, Eric W.; Patel, Vaishali; Furukawa, Michael F.; King, Jennifer

    2016-01-01

    While adoption of electronic health record (EHR) systems has grown rapidly, little is known about physicians’ perspectives on its adoption and use. Nationally representative survey data from 2011 are used to compare the perspectives of physicians who have adopted EHRs with those that have yet to do so across three key areas: the impact of EHRs on clinical care, practice efficiency and operations; barriers to EHR adoption; and factors that influence physicians to adopt EHRs. Despite significant differences in perspectives between adopters and non-adopters, the majority of physicians perceive that EHR use yields overall clinical benefits, more efficient practices and financial benefits. Purchase cost and productivity loss are the greatest barriers to EHR adoption among both adopters and non-adopters; although non-adopters have significantly higher rates of reporting these as barriers. Financial incentives and penalties, technical assistance, and the capability for electronic health information exchange are factors with the greatest influence on EHR adoption among all physicians. However, a substantially higher proportion of non-adopters regard various national health IT policies, and in particular, financial incentives or penalties as a major influence in their decision to adopt an EHR system. Contrasting these perspectives provides a window into how national policies have shaped adoption thus far; and how these policies may shape adoption in the near future. PMID:26250087

  6. Omnidirectional wireless power transfer system supporting mobile devices

    NASA Astrophysics Data System (ADS)

    Che, Bang-Jun; Meng, Fan-Yi; Lyu, Yue-Long; Zhu, Wen-Liang; Zhang, Kuang; Yang, Guo-Hui; Fu, Jia-Hui; Zhu, Lei; Wu, Qun; Sun, Li

    2016-02-01

    An efficient method for the challenge design of an omnidirectional wireless power transfer system (OWPT) is proposed. The OWPT is realized utilizing the rotating magnetic field, which is generated by the proposed 2-D transmitter. The transmitter is composed by two mutually perpendicular loops fed by two excitation sources with the same magnitude and 90° phase difference. An OWPT system prototype is fabricated and measured. Experimental results demonstrate that the system can deliver power to receivers moving around the transmitter with a steady transfer efficiency. Furthermore, the magnitude distribution of the rotating magnetic field can be controlled by the feeding phase difference between the two loops. This capability enables the OWPT system to focus energy for device moving in a limited receiving angle range.

  7. Technology transfer of NASA microwave remote sensing system

    NASA Technical Reports Server (NTRS)

    Akey, N. D.

    1981-01-01

    Viable techniques for effecting the transfer from NASA to a user agency of state-of-the-art airborne microwave remote sensing technology for oceanographic applications were studied. A detailed analysis of potential users, their needs and priorities; platform options; airborne microwave instrument candidates; ancillary instrumentation; and other, less obvious factors that must be considered were studied. Conclusions and recommendations for the development of an orderly and effective technology transfer of an airborne microwave system that could meet the specific needs of the selected user agencies are reported.

  8. Quartz microbalance device for transfer into ultrahigh vacuum systems

    SciTech Connect

    Stavale, F.; Achete, C. A.; Niehus, H.

    2008-10-15

    An uncomplicated quartz microbalance device has been developed which is transferable into ultrahigh vacuum (UHV) systems. The device is extremely useful for flux calibration of different kinds of material evaporators. Mounted on a commercial specimen holder, the device allows fast quartz microbalance transfer into the UHV and subsequent positioning exactly to the sample location where subsequent thin film deposition experiments shall be carried out. After backtransfer into an UHV sample stage, the manipulator may be loaded in situ with the specimen suited for the experiment. The microbalance device capability is demonstrated for monolayer and submonolayer vanadium depositions with an achieved calibration sensitivity of less the 0.001 ML coverage.

  9. Information Systems Integration and Enterprise Application Integration (EAI) Adoption: A Case from Financial Services

    ERIC Educational Resources Information Center

    Lam, Wing

    2007-01-01

    Increasingly, organizations find that they need to integrate large number of information systems in order to support enterprise-wide business initiatives such as e-business, supply chain management and customer relationship management. To date, organizations have largely tended to address information systems (IS) integration in an ad-hoc manner.…

  10. Public Leadership Competencies in Adoption of Enterprise Systems at Federal Government Institutions

    ERIC Educational Resources Information Center

    Lapham, John Edmund

    2009-01-01

    The Federal Government continues to implement enterprise systems (information and communication technology solutions) as part of reinvention and business transformation. Enterprise system implementations are complex, costly, and often under achieving endeavors requiring that effective public leaders engage and influence the sociotechnical projects…

  11. Implementation of a Technological Innovation: Factors Influencing the Adoption of a New Student Information System

    ERIC Educational Resources Information Center

    Johnston, Katrina M.

    2013-01-01

    School information systems (SIS) have the potential to cause a change in a school's technical, structural, psycho-social, and managerial systems. Implementation of a technological innovation such as an SIS is not a one-step occurrence; it is a process that occurs over time. Implementing any technological innovation involves active learning…

  12. Why are employers prodding health-care providers to adopt new management systems?: reducing the cost of health care.

    PubMed

    De Feo, Joseph A

    2004-01-01

    Increasingly concerned about the escalating costs of health-care insurance coverage, the quality of health-care delivery, and the escalating costs of delivering clinical services, employers are taking action. They are prodding health-care providers and insurers to adopt breakthrough management systems aimed at reducing costs related to poorly performing services and processes--and at the same time improving clinical outcomes. Doing this will require all members of the health-care value chain to work together to improve each and every process and procedure, whether clinical or administrative. This development presents formidable challenges to all health-care providers, insurers, employees, and patients. PMID:15085703

  13. Pneumatic Regolith Transfer Systems for In-Situ Resource Utilization

    NASA Technical Reports Server (NTRS)

    Mueller, Robert P.; Townsend, Ivan I., III; Mantovani, James G.

    2010-01-01

    One aspect of In-Situ Resource Utilization (lSRU) in a lunar environment is to extract oxygen and other elements from the minerals that make up the lunar regolith. Typical ISRU oxygen production processes include but are not limited to hydrogen reduction, carbothermal and molten oxide electrolysis. All of these processes require the transfer of regolith from a supply hopper into a reactor for chemical reaction processing, and the subsequent extraction of the reacted regolith from the reactor. This paper will discuss recent activities in the NASA ISRU project involved with developing pneumatic conveying methods to achieve lunar regolith simulant transfer under I-g and 1/6-g gravitational environments. Examples will be given of hardware that has been developed and tested by NASA on reduced gravity flights. Lessons learned and details of pneumatic regolith transfer systems will be examined as well as the relative performance in a 1/6th G environment

  14. Documentation requirements for Applications Systems Verification and Transfer projects (ASVTs)

    NASA Technical Reports Server (NTRS)

    Suchy, J. T.

    1977-01-01

    NASA's Application Systems Verification and Transfer Projects (ASVTs) are deliberate efforts to facilitate the transfer of applications of NASA-developed space technology to users such as federal agencies, state and local governments, regional planning groups, public service institutions, and private industry. This study focused on the role of documentation in facilitating technology transfer both to primary users identified during project planning and to others with similar information needs. It was understood that documentation can be used effectively when it is combined with informal (primarily verbal) communication within each user community and with other formal techniques such as organized demonstrations and training programs. Documentation examples from eight ASVT projects and one potential project were examined to give scope to the investigation.

  15. Quantifying ‘Causality’ in Complex Systems: Understanding Transfer Entropy

    PubMed Central

    Abdul Razak, Fatimah; Jensen, Henrik Jeldtoft

    2014-01-01

    ‘Causal’ direction is of great importance when dealing with complex systems. Often big volumes of data in the form of time series are available and it is important to develop methods that can inform about possible causal connections between the different observables. Here we investigate the ability of the Transfer Entropy measure to identify causal relations embedded in emergent coherent correlations. We do this by firstly applying Transfer Entropy to an amended Ising model. In addition we use a simple Random Transition model to test the reliability of Transfer Entropy as a measure of ‘causal’ direction in the presence of stochastic fluctuations. In particular we systematically study the effect of the finite size of data sets. PMID:24955766

  16. Election Criteria for the Adoption of an Augmentative Communication System: Preliminary Considerations.

    ERIC Educational Resources Information Center

    Shane, Howard C.; Bashir, Anthony S.

    1980-01-01

    Criteria for determining candidacy for an augmentative communication system include a consideration of cognitive, oral reflex, language, motor, intelligibility, emotional, chronological age, previous therapy, imitative, and environmental factors of the communication disordered individual. (Author/PHR)

  17. Instrument transfer function of slope measuring deflectometry systems.

    PubMed

    Su, Tianquan; Maldonado, Alejandro; Su, Peng; Burge, James H

    2015-04-01

    Slope measuring deflectometry (SMD) systems are developing rapidly in testing freeform optics. They measure the surface slope using a camera and an incoherent source. The principle of the test is mainly discussed in geometric optic domain. The system response as a function of spatial frequency or instrument transfer function (ITF) has yet to be studied thoroughly. Through mathematical modeling, simulation, and experiment we show that the ITF of an SMD system is very close to the modulation transfer function of the camera used. Furthermore, the ITF can be enhanced using a deconvolution filter. This study will lead to more accurate measurements in SMD and will show the physical optics nature of these tests. PMID:25967213

  18. Evaluation of Knowledge, Attitude, Practise and Adoption Among Health Care Professionals for Informatics/Computerised Technology Systems.

    PubMed

    Karthik, Kavitha; Munuswamy, Suresh

    2016-01-01

    This proposed study will be conducted in Telangana and Tamil Nadu states in India. Mapping of Health care Professionals by a web-based Delphi technique followed by Focus Group Discussion and Evaluation of Knowledge, Attitude, Practise and Adoption among Health Care Professionals for informatics/computerised technology systems by using structured questionnaire for knowledge and practice and for Attitudes toward Computers in Healthcare (P.A.T.C.H.) Scale will be used to collect the data. This study results will create evidence on present and relevant informatics/computerized technology systems needs and help the research team to develop informatics competencies list and design an online or offline skill up gradation programs for health professionals in India according to their diverse roles in the health care system. The researcher team believes these results will have National relevance to the current focus areas of Government of India and to strengthen the Health Informatics Program offered in IIPH, Hyderabad. PMID:27332450

  19. Conjugate heat transfer analysis of an ultrasonic molten metal treatment system

    NASA Astrophysics Data System (ADS)

    Zhu, Youli; Bian, Feilong; Wang, Yanli; Zhao, Qian

    2014-09-01

    In piezoceramic ultrasonic devices, the piezoceramic stacks may fail permanently or function improperly if their working temperatures overstep the Curie temperature of the piezoceramic material. While the end of the horn usually serves near the melting point of the molten metal and is enclosed in an airtight chamber, so that it is difficult to experimentally measure the temperature of the transducer and its variation with time, which bring heavy difficulty to the design of the ultrasonic molten metal treatment system. To find a way out, conjugate heat transfer analysis of an ultrasonic molten metal treatment system is performed with coupled fluid and heat transfer finite element method. In modeling of the system, the RNG model and the SIMPLE algorithm are adopted for turbulence and nonlinear coupling between the momentum equation and the energy equation. Forced air cooling as well as natural air cooling is analyzed to compare the difference of temperature evolution. Numerical results show that, after about 350 s of working time, temperatures in the surface of the ceramic stacks in forced air cooling drop about 7 K compared with that in natural cooling. At 240 s, The molten metal surface emits heat radiation with a maximum rate of about 19 036 W/m2, while the heat insulation disc absorbs heat radiation at a maximum rate of about 7922 W/m2, which indicates the effectiveness of heat insulation of the asbestos pad. Transient heat transfer film coefficient and its distribution, which are difficult to be measured experimentally are also obtained through numerical simulation. At 240 s, the heat transfer film coefficient in the surface of the transducer ranges from -17.86 to 20.17 W/(m2 · K). Compared with the trial and error method based on the test, the proposed research provides a more effective way in the design and analysis of the temperature control of the molten metal treatment system.

  20. Transfer efficiency analysis of wireless power transfer system under frequency drift

    NASA Astrophysics Data System (ADS)

    Huang, S. D.; Li, Z. Q.; Lu, K. Y.

    2015-05-01

    Magnetic resonant wireless power transfer (WPT) is an emerging technology that may create new applications for wireless power charging. However, low efficiency resulting from resonant frequency drift is a main obstructing factor for promoting this technology. In this paper, the system efficiency and input impedance are obtained by solving the system equivalent equations and based on that a method of adjusting the operating frequency and load resistor is proposed. When resonant frequency drift occurs, the WPT system can now operate at quasi-resonant state and the efficiency can be improved by using the proposed method. The WPT system via magnetic resonance coupling is designed. Simulation and experimental results validating the proposed method are given.

  1. An 80 Mbytes/s data transfer and processing system

    NASA Astrophysics Data System (ADS)

    Belusevic, R.; Nixon, G.; Shaw, D.

    1990-11-01

    We describe hardware and software aspects of a very fast and versatile, yet conceptually simple, data transfer and processing system for use with future accelerators. It consists of a transputer-based crate controller (CC), which includes an Intel i860 microcomputer, and of a set of readout cards (RC), each containing a digital signal processor (DSP) for fast data parametrisation and compaction. The reduced data is written into a dual port memory (DPM), where it can be accessed concurrently by the transputer and transferred to a common DPM on the CC card. A crateful of data thus assembled at one place can further be processed by the powerful i860 microcomputer. Address generators (simple binary counters) are included on the crate controller and each readout card to enable direct memory access (DMA) operations, resulting in a considerable increase in data transfer speed (maximum 80 Mbytes/s). The use of a transputer as the sole controlling processor, in conjunction with DPMs, renders bus arbitration unnecessary, leading to very simple interfacing logic and operating software. The four high-speed serial links of the transputer greatly facilitate downloading of programs and intercrate communications. An Intel i960CA processor, situated on the CC card, is used for fast data transfer between crates by means of its 32-bit wide DMA channel. The operating software is written in the Occam language, which was specially developed for programming concurrent systems based on transputers.

  2. Heat transfer in vertically aligned phase change energy storage systems

    SciTech Connect

    El-Dessouky, H.T.; Bouhamra, W.S.; Ettouney, H.M.; Akbar, M.

    1999-05-01

    Convection effects on heat transfer are analyzed in low temperature and vertically aligned phase change energy storage systems. This is performed by detailed temperature measurements in the phase change material (PCM) in eighteen locations forming a grid of six radial and three axial positions. The system constitutes a double pipe configuration, where commercial grade paraffin wax is stored in the annular space between the two pipes and water flows inside the inner pipe. Vertical alignment of the system allowed for reverse of the flow direction of the heat transfer fluid (HTF), which is water. Therefore, the PCM is heated from the bottom for HTF flow from bottom to top and from the top as the HTF flow direction is reversed. For the former case, natural convection affects the melting process. Collected data are used to study variations in the transient temperature distribution at axial and radial positions as well as for the two-dimensional temperature field. The data are used to calculate the PCM heat transfer coefficient and to develop correlations for the melting Fourier number. Results indicate that the PCM heat transfer coefficient is higher for the case of PCM heating from bottom to top. Nusselt number correlations are developed as a function of Rayleigh, Stefan, and Fourier numbers for the HTF flow from bottom to top and as a function of Stefan and Fourier numbers for HTF flow from top to bottom. The enhancement ratio for heat transfer caused by natural convection increases and then levels off as the inlet temperature of the HTF is increased.

  3. Computer simulations for the AdOpt system employing liquid crystal wavefront correctors.

    NASA Astrophysics Data System (ADS)

    Bonaccini, D.; Brusa, G.; Esposito, S.; Biliotti, V.; Ranfagni, P.; Stefanini, P.

    A model of the AO servo-loop system employing LC-based wavefront correctors is described. Response times of the servo and of the actuators are taken into account. Simulation results are presented for 4- and 8-m class telescopes.

  4. Critical Success Factors for Adoption of Web-Based Learning Management Systems in Tanzania

    ERIC Educational Resources Information Center

    Lwoga, Edda Tandi

    2014-01-01

    This paper examines factors that predict students' continual usage intention of web-based learning content management systems in Tanzania, with a specific focus at Muhimbili University of Health and Allied Science (MUHAS). This study sent a questionnaire surveys to 408 first year undergraduate students, with a rate of return of 66.7. This study…

  5. Investigating Nigerian Primary School Teachers' Preparedness to Adopt Personal Response System in ESL Classroom

    ERIC Educational Resources Information Center

    Agbatogun, Alaba Olaoluwakotansibe

    2012-01-01

    This study investigated the extent to which computer literacy dimensions (computer general knowledge, documents and documentations, communication and surfing as well as data inquiry), computer use and academic qualification as independent variables predicted primary school teachers' attitude towards the integration of Personal Response System in…

  6. 77 FR 49991 - Small Business Size Standards; Adoption of 2012 North American Industry Classification System for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ..., replacing the Standard Industrial Classification (SIC) System, effective October 1, 2000 (65 FR 30836 (May 5... modification, NAICS 2002 (66 FR 3825 (January 16, 2001)), into its table of size standards, effective October 1, 2002 (67 FR 52597 (August 13, 2002)). SBA incorporated the second modification, NAICS 2007 (71 FR...

  7. Examining Barriers in Faculty Adoption of an E-Portfolio System

    ERIC Educational Resources Information Center

    Swan, Gerry

    2009-01-01

    This paper is a report on the findings of a study conducted on the implementation of a portfolio system at the University of Kentucky. Interviews were conducted with faculty members and university supervisors about the use of a portfolio management tool that had been implemented in the teacher education program. Factors such as small program size…

  8. Why the United States should adopt a single-payer system of health care finance.

    PubMed

    DeGrazia, D

    1996-06-01

    Although nothing could be less fashionable today than talk of comprehensive health care reform, the major problems of American health care have not gone away. Only a radical change in the way the U.S. finances health care--specifically, a single-payer system--will permit the achievement of universal coverage while keeping costs reasonably under control. Evidence from other countries, especially Canada, suggests the promise of this approach. In defending the single-payer approach, the author identifies several political and cultural factors that make it difficult for Americans to obtain a clear view of this option. Finally, the author argues that much discussion of rationing is vitiated by bracketing more systemic questions to which the issue of rationing is inextricably linked. PMID:10158031

  9. On identifying transfer functions and state equations for linear systems.

    NASA Technical Reports Server (NTRS)

    Shieh, L. S.; Chen, C. F.; Huang, C. J.

    1972-01-01

    Two methods are established for identifying constant-coefficient, C to the 2n power type of noise-free linear systems if the time response data of the input-output or of all states are known. 2n response data are required to identify an nth-order transfer function or state equation for an unknown linear system. The order of the unknown system can be identified by checking a sequence of determinants. The Z transform and its inversion are mainly used.

  10. Energy transfer in systems with random forcing and nonlinear dissipation

    NASA Astrophysics Data System (ADS)

    Pignol, Ricardo Jorge

    The purpose of this thesis is to study energy transfer in nonlinear systems. In the first part, I focus on a model of two nonlinearly coupled (complex) oscillators subject to stochastic forcing and nonlinear dissipation. This model arises from isolating an individual resonant quartet in a general dispersive system, and reducing it further by exploiting some of the system's symmetries. It turns out that the reduced model exhibits a rich and complex behavior encountered in far larger systems, with two qualitatively distinct regimes arising as one varies the system's single non-dimensional parameter: one that can be characterized as a perturbation of thermal equilibrium, and another highly constrained state, with phase and amplitude locking , and singular invariant measures. The relative simplicity of the reduced model allows a thorough numerical and theoretical treatment (including a closed expression for the system's invariant measures) that furnishes valuable insight on the energy transfer process in systems with much higher dimensionality. In the second part, the damped oscillator is replaced by an individual mode of the inviscid Burgers equation. Here, the dissipation occurs through shocks. Despite the complexity resulting from the inclusion of a nonlinear partial differential equation, I show that much of this system's behavior can be inferred precisely from a reduction to one of the cases studied in the first part.

  11. Use of influence diagrams in gas transfer system option prioritization

    SciTech Connect

    Heger, A.S.; Garcia, M.D.

    1995-08-01

    A formal decision-analysis methodology was applied to aid the Department of Energy (DOE) in deciding which of several gas transfer system (GTS) options should be selected. The decision objectives for this case study, i.e., risk and cost, were directly derived from the DOE guidelines. Influence diagrams were used to define the structure of the decision problem and clearly delineate the flow if information. A set of performance matrices wee used in conjunction with the influence diagrams to assess and evaluate the degree to which the objectives of the case study were met. These performance measures were extracted from technical models, design and operating data, and professional judgments. The results were aggregated to provide an overall evaluation of the different design options of the gas transfer system. Consequently, the results of this analysis were used as an aid to DOE to select a viable GTS option.

  12. Technology of H-II Transfer Vehicle Rendezvous System

    NASA Astrophysics Data System (ADS)

    Kasai, Toru; Ueda, Satoshi; Uematsu, Hirohiko

    The H-II Transfer Vehicle (HTV), which is a Japanese unmanned cargo transfer spacecraft, will deliver supplies to the International Space Station (ISS). The first HTV will be launched in 2009 from the Tanegashima Space Center aboard an H-IIB launch vehicle with up to 6,000kg of supplies. HTV approaches to the ISS and the Space Station Remote Manipulator System (SSRMS), known as Canadarm2, will grapple the HTV and berth it to the ISS. After the supplies, the HTV will then be loaded with waste materials and then separated from the ISS by SSRMS. HTV conducts departure sequence from ISS after release from SSRMS and reentry to the atmosphere. In this paper, technology of HTV automated Guidance, Navigation and Control (GN&C) system is presented.

  13. Early results of pediatric appendicitis after adoption of diagnosis-related group-based payment system in South Korea

    PubMed Central

    Moon, Suk-Bae

    2015-01-01

    Purpose As an alternative to the existing fee-for-service (FFS) system, a diagnosis-related group (DRG)-based payment system has been suggested. The aim of this study was to investigate the early results of pediatric appendicitis treatment under the DRG system, focusing on health care expenditure and quality of health care services. Patients and methods The medical records of 60 patients, 30 patients before (FFS group), and 30 patients after adoption of the DRG system (DRG), were reviewed retrospectively. Results Mean hospital stay was shortened, but the complication and readmission rates did not worsen in the DRG. Overall health care expenditure and self-payment decreased from Korean Won (KRW) 2,499,935 and KRW 985,540, respectively, in the FFS group to KRW 2,386,552 and KRW 492,920, respectively, in the DRG. The insurer’s payment increased from KRW 1,514,395 in the FFS group to KRW 1,893,632 in the DRG. For patients in the DRG, calculation by the DRG system yielded greater overall expenditure (KRW 2,020,209 vs KRW 2,386,552) but lower self-payment (KRW 577,803 vs KRW 492,920) than calculation by the FFS system. Conclusion The DRG system worked well in pediatric patients with acute appendicitis in terms of cost-effectiveness over the short term. The gradual burden on the national health insurance fund should be taken into consideration. PMID:26648734

  14. Evaluating the compliance of Keck's LGSAO automated aircraft protection system with FAA adopted criteria

    NASA Astrophysics Data System (ADS)

    Stomski, Paul J.; Campbell, Randy; Murphy, Thomas W.

    2014-07-01

    The W. M. Keck Observatory (WMKO) applied for and received a determination of no-objection from the Federal Aviation Administration (FAA) for laser guide star adaptive optics (LGS-AO) operations using an automated aircraft protection system (APS) in late 2013. WMKO's APS, named AIRSAFE, uses transponder based aircraft detection (TBAD) to replace human aircraft spotters. The FAA required WMKO to self-certify AIRSAFE compliance with SAE Aerospace Standard 6029A: "Performance Criteria for Laser Control Measures Used for Aviation Safety"[1] (AS- 6029A). AS-6029A prescribes performance and administrative criteria for an APS; essentially, requiring AIRSAFE to adequately protect all types of aircraft, traveling at any speed, altitude, distance and direction reasonably expected in the operating environment. A description of the analysis that comprises this compliance evaluation is the main focus of this paper. Also discussed is the AIRSAFE compliance with AS-6029A administrative criteria that includes characterization of site specific air traffic, failure modes, limitations, operating procedures, preventative maintenance procedures, and periodic system test procedures.

  15. Examining and elucidation of human weight cycle model adopting e-cell simulation system

    PubMed Central

    Rajesh, Durairaj; Muthukumar, Subramanian; Siva, Durairaj; Saibaba, Ganesan; Dhanasekaran, Dharumadhurai; Archunan, Govindaraju

    2015-01-01

    Cellular rhythms regulate various physiological functions in circadian oscillatory mechanisms. Weight cycling or ‘yo-yo’ dieting is an evitable process in human, because of subsequent loss and regain of body weight due to irregular diet. Human weight cycle (HWC) is the major factor for causing global epidemic diseases in human beings. Understanding the HWC process would provide potent additional knowledge to prevent obesity. However till date, there is no study dealing with examine the HWC model using virtual cell simulation based on system biological approach. Therefore, the present study was designed to develop a computational HWC model, which was simulated using E-cell system v3.0. The developed model has the cyclic feedback reactions of three significant variables (the consecutive cycles of weight loss in continuous food intake (Q) and regain of body weight (P) at highest threshold point of cognitive restraint (R)) which are obtained by mathematical modelling. The dynamic plot results supported that the PQR variables depicted sustained oscillation with reversible modification due to protein diet. By contrast, the virtual model simulation would provide extensive information on HWC, which might provide knowledge to develop HWC linked with obesity pathway. The presents study concludes that optimization of body weight is essential to prevent the obesity based diseases. PMID:26339149

  16. [Advances in eHealth in Colombia: adoption of the National Cancer Information System].

    PubMed

    Rivillas, Juan Carlos; Huertas Quintero, Jancy Andrea; Montaño Caicedo, José Ivo; Ospina Martínez, Martha Lucía

    2014-01-01

    The use of the eHealth has become feasible and acceptable in a variety of fields and contexts in Colombia. This article reports on the Colombian experience using eHealth tools applied to cancer, as well as the challenges, emerging trends, and positive outcomes related to the use of information technology and communication in the national health system. One of these outcomes has been Colombia's National Cancer Information System, in place since 2012, which is the result of political action and strategies focused on applying these innovative technologies in the field of health. The final judgment will depend of the extent to which it is possible to guide timely, effective, and coordinated interventions to optimize care for people with cancer, improve their quality of life, and significantly reduce inequalities. Once this is achieved, the next step should be to replicate the experience and apply eHealth-based tools more broadly in the contexts and fields that the country and the Region require. PMID:25211575

  17. Examining and elucidation of human weight cycle model adopting e-cell simulation system.

    PubMed

    Rajesh, Durairaj; Muthukumar, Subramanian; Siva, Durairaj; Saibaba, Ganesan; Dhanasekaran, Dharumadhurai; Archunan, Govindaraju

    2015-01-01

    Cellular rhythms regulate various physiological functions in circadian oscillatory mechanisms. Weight cycling or 'yo-yo' dieting is an evitable process in human, because of subsequent loss and regain of body weight due to irregular diet. Human weight cycle (HWC) is the major factor for causing global epidemic diseases in human beings. Understanding the HWC process would provide potent additional knowledge to prevent obesity. However till date, there is no study dealing with examine the HWC model using virtual cell simulation based on system biological approach. Therefore, the present study was designed to develop a computational HWC model, which was simulated using E-cell system v3.0. The developed model has the cyclic feedback reactions of three significant variables (the consecutive cycles of weight loss in continuous food intake (Q) and regain of body weight (P) at highest threshold point of cognitive restraint (R)) which are obtained by mathematical modelling. The dynamic plot results supported that the PQR variables depicted sustained oscillation with reversible modification due to protein diet. By contrast, the virtual model simulation would provide extensive information on HWC, which might provide knowledge to develop HWC linked with obesity pathway. The presents study concludes that optimization of body weight is essential to prevent the obesity based diseases. PMID:26339149

  18. Controlled Population Transfer in a Double Quantum Dot System

    SciTech Connect

    Fountoulakis, Antonios; Terzis, Andreas F.; Paspalakis, Emmanuel

    2007-12-26

    We study the potential for controlled population transfer between the ground states of two anharmonic coupled quantum dots. We propose a method based on the interaction of the quantum dot structure with external electromagnetic fields. The interaction of the quantum dot system with the electromagnetic fields is studied with the use of the time-dependent Schroedinger equation. We present numerical results for an asymmetric quantum dot structure.

  19. Nonlinear energy transfer in classical and quantum systems.

    PubMed

    Manevitch, Leonid; Kovaleva, Agnessa

    2013-02-01

    In this paper we investigate the effect of slowly-varying parameters on the energy transfer in a weakly coupled system. For definiteness, we consider a system of two nonlinear oscillators, in which the directly excited first oscillator with constant parameter is attached to the oscillator with slowly time-varying frequency. It is proved that the equations of the slow passage through resonance in this system are identical to the equations of nonlinear Landau-Zener (LZ) tunneling. Three types of dynamical behavior are distinguished, namely, quasilinear, moderately nonlinear, and strongly nonlinear ones. Quasilinear systems exhibit a gradual energy transfer from the excited to the attached oscillator, while moderately nonlinear systems are characterized by an abrupt transition from the energy localization on the excited oscillator to the localization on the attached oscillator. In strongly nonlinear systems, the transition from the energy localization to strong energy exchange between the oscillators is revealed. Explicit approximate solutions describing the transient processes in moderately and strongly nonlinear systems are suggested. Correctness of the constructed approximations is confirmed by numerical results. The results presented in this paper, in addition to providing an analytical framework for understanding the transient dynamics, suggest an approximate procedure for solving the nonlinear LZ problem with arbitrary initial conditions over a finite time-interval. PMID:23496588

  20. Emergency flight control system using one engine and fuel transfer

    NASA Technical Reports Server (NTRS)

    Burcham, Jr., Frank W. (Inventor); Burken, John J. (Inventor); Le, Jeanette (Inventor)

    2000-01-01

    A system for emergency aircraft control uses at least one engine and lateral fuel transfer that allows a pilot to regain control over an aircraft under emergency conditions. Where aircraft propulsion is available only through engines on one side of the aircraft, lateral fuel transfer provides means by which the center of gravity of the aircraft can be moved over to the wing associated with the operating engine, thus inducing a moment that balances the moment from the remaining engine, allowing the pilot to regain control over the aircraft. By implementing the present invention in flight control programming associated with a flight control computer (FCC), control of the aircraft under emergency conditions can be linked to the yoke or autopilot knob of the aircraft. Additionally, the center of gravity of the aircraft can be shifted in order to effect maneuvers and turns by spacing such center of gravity either closer to or farther away from the propelling engine or engines. In an alternative embodiment, aircraft having a third engine associated with the tail section or otherwise are accommodated and implemented by the present invention by appropriately shifting the center of gravity of the aircraft. Alternatively, where a four-engine aircraft has suffered loss of engine control on one side of the plane, the lateral fuel transfer may deliver the center of gravity closer to the two remaining engines. Differential thrust between the two can then control the pitch and roll of the aircraft in conjunction with lateral fuel transfer.

  1. DEVELOPING THE NATIONAL GEOTHERMAL DATA SYSTEM ADOPTION OF CKAN FOR DOMESTIC & INTERNATIONAL DATA DEPLOYMENT

    SciTech Connect

    Clark, Ryan J.; Kuhmuench, Christoph; Richard, Stephen M.

    2013-01-01

    The National Geothermal Data System (NGDS) De- sign and Testing Team is developing NGDS software currently referred to as the “NGDS Node-In-A-Box”. The software targets organizations or individuals who wish to host at least one of the following: • an online repository containing resources for the NGDS; • an online site for creating metadata to register re- sources with the NGDS • NDGS-conformant Web APIs that enable access to NGDS data (e.g., WMS, WFS, WCS); • NDGS-conformant Web APIs that support dis- covery of NGDS resources via catalog service (e.g. CSW) • a web site that supports discovery and under- standing of NGDS resources A number of different frameworks for development of this online application were reviewed. The NGDS Design and Testing Team determined to use CKAN (http://ckan.org/), because it provides the closest match between out of the box functionality and NGDS node-in-a-box requirements. To achieve the NGDS vision and goals, this software development project has been inititated to provide NGDS data consumers with a highly functional inter- face to access the system, and to ease the burden on data providers who wish to publish data in the sys- tem. It is important to note that this software package constitutes a reference implementation. The NGDS software is based on open standards, which means other server software can make resources available, and other client applications can utilize NGDS data. A number of international organizations have ex- pressed interest in the NGDS approach to data access. The CKAN node implementation can provide a sim- ple path for deploying this technology in other set- tings.

  2. Downward heat transfer in a miscible melting system

    SciTech Connect

    Farhadieh, R.

    1981-01-01

    The integrity of an ex-vessel core-retention system in the event of core meltdown is of concern in PAHR safety assessment. Several ex-vessel core retention concepts incorporate sacrificial beds. The integrity of the ex-vessel core-retention system is dependent on the directional growth of the molten pool into soluble boundaries of the sacrificial bed. Mutual dissolution of the molten pool of core-debris and the sacrificial material is expected to change the thermal characteristics of the pool and thus affect the heat transfer to the boundaries. The two-dimensional simulation study of the penetration of a dense, hot liquid pool into the boundaries of a meltable, soluble solid revealed the dependency of the directional pool growth on the density ratio, rho*, of the liquid pool to the meltable solid. In the one-dimensional study of the downward penetration of the hot pool into a soluble boundary four different hydrodynamic flow regimes were identified that occurred at different ranges of rho*. The downward heat transfer enhanced beyond rho* approx. = 1.1. The present study investigates the effect of test cell geometry and material properties on the downward heat transfer in a horizontal melting system.

  3. Adoption and resistance: reflections on human, organizational, and information technologies in picture archive and communication systems (PACS)

    NASA Astrophysics Data System (ADS)

    Sappington, Rodney W.

    2005-04-01

    In research conducted at academic and community hospitals in the United States since 2001, this paper examines complex human and technological relationships employed to renegotiate behavior within hospital administrative and clinical cultures. In the planning and implementation of PACS in a four-facility hospital we will enter into what can be described as processes of "adoption" and "resistance", seemingly opposite approaches to system implementation, which I argue are in fact key responses to planning, design, and customization of imaging and information systems in a context of convergence. In a larger context of convergence known as NBIC tools (nanotechnology, biotechnology, information technology, and cognitive sciences) it has become increasingly clear to leaders in the field that it is essential to redesign organizational technologies. A novel system has little chance of being fully utilized by conventional organizational structures in an era of system convergence. The challenge of embracing a larger systems perspective lies in opening untapped potential within the healthcare enterprise by preparing the ground for reflection on new approaches to training, and bridging specialized knowledge across computer engineering, clinical decision making, and organizational perspectives for the benefit of patient care. Case studies will demonstrate how organizational and system design technologies are crucial in insuring that PACS implementation strategies can encourage the emergence of new levels of quality for patient care. The goal is to provide successful design-build models that are true to organizational specificity, persons, and clinical practices undergoing change and uncertainty.

  4. Parasite management extension - challenging traditional practice through adoption of a systems approach.

    PubMed

    Wilson, L; Rhodes, A P; Dodunski, G

    2015-11-01

    The drivers for anthelmintic use today are substantial and anthelmintic use has become an embedded normalised behaviour. The cheapness and easy availability of anthelmintic products has meant that New Zealand farmers have had access to easy "solutions" for dealing with parasites and minimal forward planning or system redesign has been required. Despite 30 years of messaging about the emerging issue of anthelmintic resistance, management to reduce parasitism and the need to change behaviour, farmer practice has largely remained unchanged. Traditional approaches to extension, particularly around parasite management, appear to have been quite ineffective, apart from encouraging change in anthelmintic products and a switch to use of anthelmintics in combination. More effective approaches are required. The evolving nature of anthelmintic resistance and sustainable management of parasitism require attitudes, knowledge and behaviour to change. This is a challenge for all players in the industry; researchers, manufacturers and sellers, advisors and farmers. Looking beyond agriculture to the health sector provides some insight into models of decision making and behaviour change that can inform future strategies. Features in the health belief model including concepts of self-efficacy and cues to action appear to align with the issues, challenges and culture prevailing in farming, and parasite management in particular. Programmes through which farmers have made substantial beneficial behaviour change and the lessons learnt are discussed. Effecting consistent behaviour change around parasite management will involve new approaches by all participants in the process. And the process itself also needs to change. It requires an understanding of whole-farm systems, and the consideration of all the sources of influence on the farmer and the other participants in the process. The process of knowledge sharing involving the farmer should be based on equality; each person in the process

  5. E-Beam—a new transfer system for isolator technology

    NASA Astrophysics Data System (ADS)

    Sadat, Theo; Huber, Thomas

    2002-03-01

    In every aseptic filling application, the sterile transfer of goods into the aseptic area is a challenge, and there are many different ways to do it. With isolator technology a higher sterility assurance level (SAL) is achieved. This SAL is only as good as the weakest segment in the chain of manufacturing. The transfer of goods into and out of the isolator is one of these critical segments. Today different techniques, some already well established, others still very new, are available on the market like: dry heat tunnel, autoclave, pulsed light, rapid transfer systems (RTP), H 2O 2 tunnel, UV light, etc. all these systems are either not applicable for continuous transfer, only good for heat-compatible materials like glass, or do not guarantee a 6 log spore reduction. E-Beam opens new perspectives in this field. With E-beam technology it is possible to transfer heat-sensitive (plastic), pre-sterilised materials at high speed, continuously into an aseptic area. E-Beam unifies three different technologies, that result in a very efficient and high-speed decontamination machine designed for the pharmaceutical industry. First, there is the electron beam that decontaminates the goods and an accurate shielding that protects the surrounding from this beam. Second, there is the conveyor system that guarantees the output and the correct exposure time underneath the beam. And third, there is the isolator interface to provide correct differential pressure and clean air inside the tunnel as well as the decontamination of the tunnel with H 2O 2 prior to production. The E-beam is a low-energy electron beam, capable of decontaminating any kind of surface. It penetrates only a few micrometers into the material and therefore does not deform the packaging media. Currently, machines are being built to transfer pre-sterilised syringes, packed in plastic tubs with a Tyvek cover into an aseptic filling isolator with the following data: decontamination efficiency of 10 6 (6 log spore

  6. Automated pneumatic transfer irradiation system for delayed neutron counting

    SciTech Connect

    Heifer, Paul G.; Millard, Hugh T. Jr.; Zermane, Albert J

    1982-07-01

    The Geological Survey TRIGA Reactor has been used for uranium and thorium neutron activation analysis by delayed neutron counting for the past eleven years. As the requirements for analysis increased the original General Atomic pneumatic system was upgraded in several stages. By 1979 we had reached the practical limits of safe through-put for that system and a new pneumatic transfer system was built. A single large Roots type blower is used to drive four individual transfer tubes simultaneously (two termini in the core and two outside the reflector). A microprocessor controls the operation and is paced by a minicomputer, which is also used to collect and reduce the counting data. Two irradiations and counting cycles are performed on each sample, one in the core, a Cd-lined terminus for thorium, and one in the reflector mounted terminus for uranium. Video displays at both the reactor console and the pneumatic system operating station indicate the status of the system and the locations of the samples at all times. This highly automated system is capable of 1,200 irradiations for delayed neutron counting in a 10 hour day, and, in addition, incorporates programmable versatility for other irradiation-counting experiments, and provides a high degree of reactor and radiological safety with only remote operator attention. (author)

  7. Specific Gene Repression by CRISPRi System Transferred through Bacterial Conjugation

    PubMed Central

    2014-01-01

    In microbial communities, bacterial populations are commonly controlled using indiscriminate, broad range antibiotics. There are few ways to target specific strains effectively without disrupting the entire microbiome and local environment. Here, we use conjugation, a natural DNA horizontal transfer process among bacterial species, to deliver an engineered CRISPR interference (CRISPRi) system for targeting specific genes in recipient Escherichia coli cells. We show that delivery of the CRISPRi system is successful and can specifically repress a reporter gene in recipient cells, thereby establishing a new tool for gene regulation across bacterial cells and potentially for bacterial population control. PMID:25409531

  8. Two-dimensional modulation transfer functions of image scanning systems.

    PubMed

    Simonds, R M

    1981-02-15

    Image data processing based on optical scanning and digital reconstruction frequently ignores artifacts produced by the scanning process itself. Characterization of these artifacts by measurement of system modulation transfer function (MTF) using the traditional knife-edge scan technique produces only one section of the 2-D MTF, and interpretation of this as representative of the complete MTF may yield misleading re A theoretical analysis is presented which allows reconstruction of the complete 2-D MTF from a sequence of knife-edge measurements, and an experimental example is shown for the case of a vidicon camera based scanning system. PMID:20309166

  9. RELAP5 MODEL OF THE DIVERTOR PRIMARY HEAT TRANSFER SYSTEM

    SciTech Connect

    Popov, Emilian L; Yoder Jr, Graydon L; Kim, Seokho H

    2010-08-01

    This report describes the RELAP5 model that has been developed for the divertor primary heat transfer system (PHTS). The model is intended to be used to examine the transient performance of the divertor PHTS and evaluate control schemes necessary to maintain parameters within acceptable limits during transients. Some preliminary results are presented to show the maturity of the model and examine general divertor PHTS transient behavior. The model can be used as a starting point for developing transient modeling capability, including control system modeling, safety evaluations, etc., and is not intended to represent the final divertor PHTS design. Preliminary calculations using the models indicate that during normal pulsed operation, present pressurizer controls may not be sufficient to keep system pressures within their desired range. Additional divertor PHTS and control system design efforts may be required to ensure system pressure fluctuation during normal operation remains within specified limits.

  10. Improved power transfer to wearable systems through stretchable magnetic composites

    NASA Astrophysics Data System (ADS)

    Lazarus, N.; Bedair, S. S.

    2016-05-01

    The use of wireless power transfer is common in stretchable electronics since physical wiring can be easily destroyed as the system is stretched. This work presents the first demonstration of improved inductive power coupling to a stretchable system through the addition of a thin layer of ferroelastomeric material. A ferroelastomer, an elastomeric polymer loaded with magnetic particulates, has a permeability greater than one while retaining the ability to survive significant mechanical strains. A recently developed ferroelastomer composite based on sendust platelets within a soft silicone elastomer was incorporated into liquid metal stretchable inductors based on the liquid metal galinstan in fluidic channels. For a single-turn inductor, the maximum power transfer efficiency rises from 71 % with no backplane, to 81 % for a rigid ferrite backplane on the transmitter side alone, to 86 % with a ferroelastomer backplane on the receiver side as well. The coupling between a commercial wireless power transmitter coil with ferrite backplane to a five-turn liquid metal inductor was also investigated, finding an improvement in power transfer efficiency from 81 % with only a rigid backplane to 90 % with the addition of the ferroelastomer backplane. Both the single and multi-turn inductors were demonstrated surviving up to 50 % uniaxial applied strain.

  11. Simplified Simulation of Mass Transfer in Double White Dwarf Systems

    NASA Astrophysics Data System (ADS)

    Vannah, Sara; Frank, Juhan

    2016-01-01

    The behavior both stable and unstable mass transfer in semi-detached double white dwarfs triggers a cornucopia of astrophysical phenomena including Type Ia supernovae and AM CVn stars. Current 3D hydrodynamic simulations of the evolution these systems following the mass transfer, binary orbital parameters, and the self-consistent gravitational field over several tens of orbital periods have produced a wealth of data. However, these simulations can take weeks to months in high-performance computing platforms to execute. To help with the interpretation of results of such large scale simulations, and to enable a quick exploration of binary parameter space, we have developed a Mathematica code that integrates forward in time a system of 5 ODEs describing the orbit-averaged evolution of the binary separation as well as the radius, mass, and spin angular momentum of both components of the binary. By adjusting a few parameters describing the mass transfer as a function of the Roche-lobe overflow and the strength of the tidal coupling between the orbit and component spins we are able to obtain approximate fits to previously run hydrodynamic simulations. This simplified simulation is able to run simulations similar to the hydrodynamic versions in a matter of seconds on a dual-core PC or Mac computer.

  12. Situ soil sampling probe system with heated transfer line

    DOEpatents

    Robbat, Jr., Albert

    2002-01-01

    The present invention is directed both to an improved in situ penetrometer probe and to a heated, flexible transfer line. The line and probe may be implemented together in a penetrometer system in which the transfer line is used to connect the probe to a collector/analyzer at the surface. The probe comprises a heater that controls a temperature of a geologic medium surrounding the probe. At least one carrier gas port and vapor collection port are located on an external side wall of the probe. The carrier gas port provides a carrier gas into the geologic medium, and the collection port captures vapors from the geologic medium for analysis. In the transfer line, a flexible collection line that conveys a collected fluid, i.e., vapor, sample to a collector/analyzer. A flexible carrier gas line conveys a carrier gas to facilitate the collection of the sample. A system heating the collection line is also provided. Preferably the collection line is electrically conductive so that an electrical power source can generate a current through it so that the internal resistance generates heat.

  13. Neural network identification of power system transfer functions

    SciTech Connect

    Gillard, D.M.; Bollinger, K.E.

    1996-03-01

    This paper describes an investigation into the use of a multilayered neural network for measuring the transfer function of a power system for use in power system stabilizer (PSS) tuning and assessing PSS damping. The objectives are to quickly and accurately measure the transfer function relating the electric power output to the AVR PSS reference voltage input of a system with the plant operating under normal conditions. In addition, the excitation signal used in the identification procedure is such that it will not adversely affect the terminal voltage or the system frequency. This research emphasized the development of a neural network that is easily trained and robust to changing system conditions. Performance studies of the trained neural network are described. Simulation studies suggest the practical feasibility of the algorithm as a stand-alone identification package and as a portion of a self-tuning algorithm requiring identification in the strategy. The same technique applied to a forward modeling scheme can be used to test the damping contribution from different control strategies.

  14. Cosmic Background Explorer (COBE) transfer orbit attitude control system

    NASA Technical Reports Server (NTRS)

    Placanica, Samuel J.; Flatley, Thomas W.

    1986-01-01

    The Cosmic Background Explorer (COBE) spacecraft will be launched by the Shuttle from Vandenberg AFB into a 300 km altitude, 99 deg inclination, 6 a.m. or 6 p.m. ascending node orbit. After release from the Remote Manipulator System (RMS) arm, an on-board monopropellant hydrazine propulsion system will raise the orbit altitude to 900 km. The spacecraft continuously spins during transfer orbit operations with the spin axis nominally horizontal and in or near the orbit plane. The blowdown propulsion system consists of twelve 5 lb thrusters (3 'spin', 3 'despin', and 6 'axial') with the latter providing initially 30 lb of force parallel to the spin axis for orbit raising. The spin/despin jets provide a constant roll rate during the transfer orbit phase of the mission and the axials control pitch and yaw. The axial thrusters are pulsed on for attitude control during coast periods and are normally on- and off-modulated for control during orbit raising. Attitude sensors employed in the control loops include an array of two-axis digital sun sensors and three planar earth scanners for position measurements, as well as six gyroscopes for rate information. System redundancy is achieved by means of unique three-axes-in-a-plane geometry. This triaxial concept results in a fail-safe operational system with no performance degradation for many different component failure modes.

  15. Modeling coherent excitation energy transfer in photosynthetic light harvesting systems

    NASA Astrophysics Data System (ADS)

    Huo, Pengfei

    2011-12-01

    Recent non-linear spectroscopy experiments suggest the excitation energy transfer in some biological light harvesting systems initially occurs coherently. Treating such processes brings significant challenge for conventional theoretical tools that usually involve different approximations. In this dissertation, the recently developed Iterative Linearized Density Matrix (ILDM) propagation scheme, which is non-perturbative and non-Markovian is extended to study coherent excitation energy transfer in various light harvesting complexes. It is demonstrated that the ILDM approach can successfully describe the coherent beating of the site populations on model systems and gives quantitative agreement with both experimental results and the results of other theoretical methods have been developed recently to going beyond the usual approximations, thus providing a new reliable theoretical tool to study this phenomenon. This approach is used to investigate the excited energy transfer dynamics in various experimentally studied bacteria light harvesting complexes, such as Fenna-Matthews-Olsen (FMO) complex, Phycocyanin 645 (PC645). In these model calculations, quantitative agreement is found between computed de-coherence times and quantum beating pattens observed in the non-linear spectroscopy. As a result of these studies, it is concluded that the stochastic resonance behavior is important in determining the optimal throughput. To begin addressing possible mechanics for observed long de-coherence time, various models which include correlation between site energy fluctuations as well as correlation between site energy and inter-site coupling are developed. The influence of both types of correlation on the coherence and transfer rate is explored using with a two state system-bath hamiltonian parametrized to model the reaction center of Rhodobacter sphaeroides bacteria. To overcome the disadvantages of a fully reduced approach or a full propagation method, a brownian dynamics

  16. System and method for transferring data on a data link

    NASA Technical Reports Server (NTRS)

    Cole, Robert M. (Inventor); Bishop, James E. (Inventor)

    2007-01-01

    A system and method are provided for transferring a packet across a data link. The packet may include a stream of data symbols which is delimited by one or more framing symbols. Corruptions of the framing symbol which result in valid data symbols may be mapped to invalid symbols. If it is desired to transfer one of the valid data symbols that has been mapped to an invalid symbol, the data symbol may be replaced with an unused symbol. At the receiving end, these unused symbols are replaced with the corresponding valid data symbols. The data stream of the packet may be encoded with forward error correction information to detect and correct errors in the data stream.

  17. Transfer-matrix scaling for diluted Ising systems

    NASA Astrophysics Data System (ADS)

    de Queiroz, S. L. A.; Stinchcombe, R. B.

    1992-09-01

    A transfer-matrix scaling technique is developed for randomly diluted systems and applied to the site-diluted Ising model on a square lattice. For each connected configuration between adjacent columns, the contribution of the respective transfer matrix to the decay of correlations is considered only as far as the ratio of the two largest eigenvalues, allowing an economical incorporation of configurational averages. Predictions for the phase boundary at and near the percolation and pure Ising limits, and for the correlation exponent η at those limits, agree with exactly known results to within 1% error with largest strip widths of only L=5. The exponent η remains near the pure value (1/4) for all intermediate concentrations until it turns over to the percolation value at the threshold.

  18. Affordable Launch Services using the Sport Orbit Transfer System

    NASA Astrophysics Data System (ADS)

    Goldstein, D. J.

    2002-01-01

    Despite many advances in small satellite technology, a low-cost, reliable method is needed to place spacecraft in their de- sired orbits. AeroAstro has developed the Small Payload ORbit Transfer (SPORTTM) system to provide a flexible low-cost orbit transfer capability, enabling small payloads to use low-cost secondary launch opportunities and still reach their desired final orbits. This capability allows small payloads to effectively use a wider variety of launch opportunities, including nu- merous under-utilized GTO slots. Its use, in conjunction with growing opportunities for secondary launches, enable in- creased access to space using proven technologies and highly reliable launch vehicles such as the Ariane family and the Starsem launcher. SPORT uses a suite of innovative technologies that are packaged in a simple, reliable, modular system. The command, control and data handling of SPORT is provided by the AeroAstro BitsyTM core electronics module. The Bitsy module also provides power regulation for the batteries and optional solar arrays. The primary orbital maneuvering capability is provided by a nitrous oxide monopropellant propulsion system. This system exploits the unique features of nitrous oxide, which in- clude self-pressurization, good performance, and safe handling, to provide a light-weight, low-cost and reliable propulsion capability. When transferring from a higher energy orbit to a lower energy orbit (i.e. GTO to LEO), SPORT uses aerobraking technol- ogy. After using the propulsion system to lower the orbit perigee, the aerobrake gradually slows SPORT via atmospheric drag. After the orbit apogee is reduced to the target level, an apogee burn raises the perigee and ends the aerobraking. At the conclusion of the orbit transfer maneuver, either the aerobrake or SPORT can be shed, as desired by the payload. SPORT uses a simple design for high reliability and a modular architecture for maximum mission flexibility. This paper will discuss the launch

  19. 12 CFR 611.1130 - Inter-System transfer of funds and equities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Inter-System transfer of funds and equities. 611.1130 Section 611.1130 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ORGANIZATION Rules for Inter-System Fund Transfers § 611.1130 Inter-System transfer of funds and equities....

  20. Building a house on shifting sand: methodological considerations when evaluating the implementation and adoption of national electronic health record systems

    PubMed Central

    2012-01-01

    Background A commitment to Electronic Health Record (EHR) systems now constitutes a core part of many governments’ healthcare reform strategies. The resulting politically-initiated large-scale or national EHR endeavors are challenging because of their ambitious agendas of change, the scale of resources needed to make them work, the (relatively) short timescales set, and the large number of stakeholders involved, all of whom pursue somewhat different interests. These initiatives need to be evaluated to establish if they improve care and represent value for money. Methods Critical reflections on these complexities in the light of experience of undertaking the first national, longitudinal, and sociotechnical evaluation of the implementation and adoption of England’s National Health Service’s Care Records Service (NHS CRS). Results/discussion We advance two key arguments. First, national programs for EHR implementations are likely to take place in the shifting sands of evolving sociopolitical and sociotechnical and contexts, which are likely to shape them in significant ways. This poses challenges to conventional evaluation approaches which draw on a model of baseline operations → intervention → changed operations (outcome). Second, evaluation of such programs must account for this changing context by adapting to it. This requires careful and creative choice of ontological, epistemological and methodological assumptions. Summary New and significant challenges are faced in evaluating national EHR implementation endeavors. Based on experiences from this national evaluation of the implementation and adoption of the NHS CRS in England, we argue for an approach to these evaluations which moves away from seeing EHR systems as Information and Communication Technologies (ICT) projects requiring an essentially outcome-centred assessment towards a more interpretive approach that reflects the situated and evolving nature of EHR seen within multiple specific settings and

  1. Heat transfer and flow in solar energy and bioenergy systems

    NASA Astrophysics Data System (ADS)

    Xu, Ben

    The demand for clean and environmentally benign energy resources has been a great concern in the last two decades. To alleviate the associated environmental problems, reduction of the use of fossil fuels by developing more cost-effective renewable energy technologies becomes more and more significant. Among various types of renewable energy sources, solar energy and bioenergy take a great proportion. This dissertation focuses on the heat transfer and flow in solar energy and bioenergy systems, specifically for Thermal Energy Storage (TES) systems in Concentrated Solar Power (CSP) plants and open-channel algal culture raceways for biofuel production. The first part of this dissertation is the discussion about mathematical modeling, numerical simulation and experimental investigation of solar TES system. First of all, in order to accurately and efficiently simulate the conjugate heat transfer between Heat Transfer Fluid (HTF) and filler material in four different solid-fluid TES configurations, formulas of an e?ective heat transfer coe?cient were theoretically developed and presented by extending the validity of Lumped Capacitance Method (LCM) to large Biot number, as well as verifications/validations to this simplified model. Secondly, to provide design guidelines for TES system in CSP plant using Phase Change Materials (PCM), a general storage tank volume sizing strategy and an energy storage startup strategy were proposed using the enthalpy-based 1D transient model. Then experimental investigations were conducted to explore a novel thermal storage material. The thermal storage performances were also compared between this novel storage material and concrete at a temperature range from 400 °C to 500 °C. It is recommended to apply this novel thermal storage material to replace concrete at high operating temperatures in sensible heat TES systems. The second part of this dissertation mainly focuses on the numerical and experimental study of an open-channel algae

  2. Modulation-transfer-function analysis for sampled image systems

    NASA Technical Reports Server (NTRS)

    Park, S. K.; Kaczynski, M.-A.; Schowengerdt, R.

    1984-01-01

    Sampling generally causes the response of a digital imaging system to be locally shift-variant and not directly amenable to Modulation Transfer Function (MTF) analysis. However, this paper demonstrates that a meaningful system response can be calculated by averaging over an ensemble of point-source system inputs to yield an MTF which accounts for the combined effects of image formation, sampling, and image reconstruction. As an illustration, the MTF of the Landsat MSS system is analyzed to reveal an average effective instantaneous field of view which is significantly larger than the commonly accepted value, particularly in the along-track direction where undersampling contributes markedly to an MTF reduction and resultant increase in image blur.

  3. Energy transfer in mesoscopic vibrational systems enabled by eigenfrequency fluctuations

    NASA Astrophysics Data System (ADS)

    Atalaya, Juan

    Energy transfer between low-frequency vibrational modes can be achieved by means of nonlinear coupling if their eigenfrequencies fulfill certain nonlinear resonance conditions. Because of the discreteness of the vibrational spectrum at low frequencies, such conditions may be difficult to satisfy for most low-frequency modes in typical mesoscopic vibrational systems. Fluctuations of the vibrational eigenfrequencies can also be relatively strong in such systems. We show that energy transfer between modes can occur in the absence of nonlinear resonance if frequency fluctuations are allowed. The case of three modes with cubic nonlinear coupling and no damping is particularly interesting. It is found that the system has a non-thermal equilibrium state which depends only on the initial conditions. The rate at which the system approaches to such state is determined by the parameters such as the noise strength and correlation time, the nonlinearity strength and the detuning from exact nonlinear resonance. We also discuss the case of many weakly coupled modes. Our results shed light on the problem of energy relaxation of low-frequency vibrational modes into the continuum of high-frequency vibrational modes. The results have been obtained with Mark Dykman. Alternative email: jatalaya2012@gmail.com.

  4. The electron transfer system of syntrophically grown Desulfovibrio vulgaris

    SciTech Connect

    Walker, C.B.; He, Z.; Yang, Z.K.; Ringbauer, Jr., J.A.; He, Q.; Zhou, J.; Voordouw, G.; Wall, J.D.; Arkin, A.P.; Hazen, T.C.; Stolyar, S.; Stahl, D.A.

    2009-05-01

    Interspecies hydrogen transfer between organisms producing and consuming hydrogen promotes the decomposition of organic matter in most anoxic environments. Although syntrophic couplings between hydrogen producers and consumers are a major feature of the carbon cycle, mechanisms for energy recovery at the extremely low free energies of reactions typical of these anaerobic communities have not been established. In this study, comparative transcriptional analysis of a model sulfate-reducing microbe, Desulfovibrio vulgaris Hildenborough, suggested the use of alternative electron transfer systems dependent upon growth modality. During syntrophic growth on lactate with a hydrogenotrophic methanogen, D. vulgaris up-regulated numerous genes involved in electron transfer and energy generation when compared with sulfate-limited monocultures. In particular, genes coding for the putative membrane-bound Coo hydrogenase, two periplasmic hydrogenases (Hyd and Hyn) and the well-characterized high-molecular weight cytochrome (Hmc) were among the most highly expressed and up-regulated. Additionally, a predicted operon coding for genes involved in lactate transport and oxidation exhibited up-regulation, further suggesting an alternative pathway for electrons derived from lactate oxidation during syntrophic growth. Mutations in a subset of genes coding for Coo, Hmc, Hyd and Hyn impaired or severely limited syntrophic growth but had little affect on growth via sulfate-respiration. These results demonstrate that syntrophic growth and sulfate-respiration use largely independent energy generation pathways and imply that understanding of microbial processes sustaining nutrient cycling must consider lifestyles not captured in pure culture.

  5. The electron transfer system of synthrophically grown desulfovibrio vulgaris

    SciTech Connect

    Walker, Christopher; He, Zhili; Yang, Zamin Koo; Ringbauer, Joseph; HE, Qiang; Zhou, Jizhong; Voordouw, Gerrit; Wall, Judy; Arkin, Adam; Hazen, Terry; Stolyar, Sergey; Stahl, David

    2009-01-01

    Interspecies hydrogen transfer between organisms producing and consuming hydrogen promotes the decomposition of organic matter in most anoxic environments. Although syntrophic coupling between hydrogen producers and consumers is a major feature of the carbon cycle, mechanisms for energy recovery at the extremely low free energies of reactions typical of these anaerobic communities have not been established. In this study, comparative transcriptional analysis of a model sulfate-reducing microbe, Desulfovibrio vulgaris Hildenborough, suggested the use of alternative electron transfer systems dependent on growth modality. During syntrophic growth on lactate with a hydrogenotrophic methanogen, numerous genes involved in electron transfer and energy generation were upregulated in D. vulgaris compared with their expression in sulfate-limited monocultures. In particular, genes coding for the putative membrane-bound Coo hydrogenase, two periplasmic hydrogenases (Hyd and Hyn), and the well-characterized high-molecular-weight cytochrome (Hmc) were among the most highly expressed and upregulated genes. Additionally, a predicted operon containing genes involved in lactate transport and oxidation exhibited upregulation, further suggesting an alternative pathway for electrons derived from lactate oxidation during syntrophic growth. Mutations in a subset of genes coding for Coo, Hmc, Hyd, and Hyn impaired or severely limited syntrophic growth but had little effect on growth via sulfate respiration. These results demonstrate that syntrophic growth and sulfate respiration use largely independent energy generation pathways and imply that to understand microbial processes that sustain nutrient cycling, lifestyles not captured in pure culture must be considered.

  6. The Electron Transfer System of Syntrophically Grown Desulfovibrio vulgaris

    SciTech Connect

    PBD; ENIGMA; GTL; VIMSS; Walker, Christopher B.; He, Zhili; Yang, Zamin K.; Ringbauer Jr., Joseph A.; He, Qiang; Zhou, Jizhong; Voordouw, Gerrit; Wall, Judy D.; Arkin, Adam P.; Hazen, Terry C.; Stolyar, Sergey; Stahl, David A.

    2009-06-22

    Interspecies hydrogen transfer between organisms producing and consuming hydrogen promotes the decomposition of organic matter in most anoxic environments. Although syntrophic couplings between hydrogen producers and consumers are a major feature of the carbon cycle, mechanisms for energy recovery at the extremely low free energies of reactions typical of these anaerobic communities have not been established. In this study, comparative transcriptional analysis of a model sulfate-reducing microbe, Desulfovibrio vulgaris Hildenborough, suggested the use of alternative electron transfer systems dependent upon growth modality. During syntrophic growth on lactate with a hydrogenotrophic methanogen, D. vulgaris up-regulated numerous genes involved in electron transfer and energy generation when compared with sulfate-limited monocultures. In particular, genes coding for the putative membrane-bound Coo hydrogenase, two periplasmic hydrogenases (Hyd and Hyn) and the well-characterized high-molecular weight cytochrome (Hmc) were among the most highly expressed and up-regulated. Additionally, a predicted operon coding for genes involved in lactate transport and oxidation exhibited up-regulation, further suggesting an alternative pathway for electrons derived from lactate oxidation during syntrophic growth. Mutations in a subset of genes coding for Coo, Hmc, Hyd and Hyn impaired or severely limited syntrophic growth but had little affect on growth via sulfate-respiration. These results demonstrate that syntrophic growth and sulfate-respiration use largely independent energy generation pathways and imply that understanding of microbial processes sustaining nutrient cycling must consider lifestyles not captured in pure culture.

  7. Homopolar machine for reversible energy storage and transfer systems

    DOEpatents

    Stillwagon, Roy E.

    1981-01-01

    A homopolar machine designed to operate as a generator and motor in reversibly storing and transferring energy between the machine and a magnetic load coil for a thermo-nuclear reactor. The machine rotor comprises hollow thin-walled cylinders or sleeves which form the basis of the system by utilizing substantially all of the rotor mass as a conductor thus making it possible to transfer substantially all the rotor kinetic energy electrically to the load coil in a highly economical and efficient manner. The rotor is divided into multiple separate cylinders or sleeves of modular design, connected in series and arranged to rotate in opposite directions but maintain the supply of current in a single direction to the machine terminals. A stator concentrically disposed around the sleeves consists of a hollow cylinder having a number of excitation coils each located radially outward from the ends of adjacent sleeves. Current collected at an end of each sleeve by sleeve slip rings and brushes is transferred through terminals to the magnetic load coil. Thereafter, electrical energy returned from the coil then flows through the machine which causes the sleeves to motor up to the desired speed in preparation for repetition of the cycle. To eliminate drag on the rotor between current pulses, the brush rigging is designed to lift brushes from all slip rings in the machine.

  8. Homopolar machine for reversible energy storage and transfer systems

    DOEpatents

    Stillwagon, Roy E.

    1978-01-01

    A homopolar machine designed to operate as a generator and motor in reversibly storing and transferring energy between the machine and a magnetic load coil for a thermo-nuclear reactor. The machine rotor comprises hollow thin-walled cylinders or sleeves which form the basis of the system by utilizing substantially all of the rotor mass as a conductor thus making it possible to transfer substantially all the rotor kinetic energy electrically to the load coil in a highly economical and efficient manner. The rotor is divided into multiple separate cylinders or sleeves of modular design, connected in series and arranged to rotate in opposite directions but maintain the supply of current in a single direction to the machine terminals. A stator concentrically disposed around the sleeves consists of a hollow cylinder having a number of excitation coils each located radially outward from the ends of adjacent sleeves. Current collected at an end of each sleeve by sleeve slip rings and brushes is transferred through terminals to the magnetic load coil. Thereafter, electrical energy returned from the coil then flows through the machine which causes the sleeves to motor up to the desired speed in preparation for repetition of the cycle. To eliminate drag on the rotor between current pulses, the brush rigging is designed to lift brushes from all slip rings in the machine.

  9. Radiative transfer in the atmosphere-ocean system: the finite-element method.

    PubMed

    Bulgarelli, B; Kisselev, V B; Roberti, L

    1999-03-20

    The finite-element method has been applied to solving the radiative-transfer equation in a layered medium with a change in the refractive index, such as the atmosphere-ocean system. The physical processes that are included in the algorithm are multiple scattering, bottom-boundary bidirectional reflectivity, and refraction and reflection at the interface between the media with different refractive properties. The incident radiation is a parallel flux on the top boundary that is characteristic of illumination of the atmosphere by the Sun in the UV, visible, and near-IR regions of the electromagnetic spectrum. The necessary changes, compared with the case of a uniformly refracting layered medium, are described. An energy-conservation test has been performed on the model. The algorithm has also been validated through comparison with an equivalent backward Monte Carlo code and with data taken from the literature, and optimal agreement was shown. The results show that the model allows energy conservation independently of the adopted phase function, the number of grid points, and the relative refractive index. The radiative-transfer model can be applied to any other layered system with a change in the refractive index. The fortran code for this algorithm is documented and is available for applications. PMID:18305777

  10. Radiative Transfer in the Atmosphere Ocean System: The Finite-Element Method

    NASA Astrophysics Data System (ADS)

    Bulgarelli, Barbara; Kisselev, Viatcheslav B.; Roberti, Laura

    1999-03-01

    The finite-element method has been applied to solving the radiative-transfer equation in a layered medium with a change in the refractive index, such as the atmosphere ocean system. The physical processes that are included in the algorithm are multiple scattering, bottom-boundary bidirectional reflectivity, and refraction and reflection at the interface between the media with different refractive properties. The incident radiation is a parallel flux on the top boundary that is characteristic of illumination of the atmosphere by the Sun in the UV, visible, and near-IR regions of the electromagnetic spectrum. The necessary changes, compared with the case of a uniformly refracting layered medium, are described. An energy-conservation test has been performed on the model. The algorithm has also been validated through comparison with an equivalent backward Monte Carlo code and with data taken from the literature, and optimal agreement was shown. The results show that the model allows energy conservation independently of the adopted phase function, the number of grid points, and the relative refractive index. The radiative-transfer model can be applied to any other layered system with a change in the refractive index. The fortran code for this algorithm is documented and is available for applications.

  11. 14 CFR 221.160 - Adoption notice.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Adoption notice. 221.160 Section 221.160... REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.160 Adoption notice. (a) When the name of a carrier is changed or when its operating...

  12. 14 CFR 221.160 - Adoption notice.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Adoption notice. 221.160 Section 221.160... REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.160 Adoption notice. (a) When the name of a carrier is changed or when its operating...

  13. 14 CFR 221.160 - Adoption notice.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Adoption notice. 221.160 Section 221.160... REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.160 Adoption notice. (a) When the name of a carrier is changed or when its operating...

  14. 14 CFR 221.160 - Adoption notice.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Adoption notice. 221.160 Section 221.160... REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.160 Adoption notice. (a) When the name of a carrier is changed or when its operating...

  15. 14 CFR 221.160 - Adoption notice.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Adoption notice. 221.160 Section 221.160... REGULATIONS TARIFFS Adoption Publications Required To Show Change in Carrier's Name or Transfer of Operating Control § 221.160 Adoption notice. (a) When the name of a carrier is changed or when its operating...

  16. Generalized hidden-mapping ridge regression, knowledge-leveraged inductive transfer learning for neural networks, fuzzy systems and kernel methods.

    PubMed

    Deng, Zhaohong; Choi, Kup-Sze; Jiang, Yizhang; Wang, Shitong

    2014-12-01

    Inductive transfer learning has attracted increasing attention for the training of effective model in the target domain by leveraging the information in the source domain. However, most transfer learning methods are developed for a specific model, such as the commonly used support vector machine, which makes the methods applicable only to the adopted models. In this regard, the generalized hidden-mapping ridge regression (GHRR) method is introduced in order to train various types of classical intelligence models, including neural networks, fuzzy logical systems and kernel methods. Furthermore, the knowledge-leverage based transfer learning mechanism is integrated with GHRR to realize the inductive transfer learning method called transfer GHRR (TGHRR). Since the information from the induced knowledge is much clearer and more concise than that from the data in the source domain, it is more convenient to control and balance the similarity and difference of data distributions between the source and target domains. The proposed GHRR and TGHRR algorithms have been evaluated experimentally by performing regression and classification on synthetic and real world datasets. The results demonstrate that the performance of TGHRR is competitive with or even superior to existing state-of-the-art inductive transfer learning algorithms. PMID:24710838

  17. User Interface Technology Transfer to NASA's Virtual Wind Tunnel System

    NASA Technical Reports Server (NTRS)

    vanDam, Andries

    1998-01-01

    Funded by NASA grants for four years, the Brown Computer Graphics Group has developed novel 3D user interfaces for desktop and immersive scientific visualization applications. This past grant period supported the design and development of a software library, the 3D Widget Library, which supports the construction and run-time management of 3D widgets. The 3D Widget Library is a mechanism for transferring user interface technology from the Brown Graphics Group to the Virtual Wind Tunnel system at NASA Ames as well as the public domain.

  18. Material transfer system in support of the plutonium immobilization program

    SciTech Connect

    Pak, D

    2000-02-23

    The Plutonium Immobilization Project is currently undertaking formulation and process development to demonstrate the immobilization of surplus plutonium in a titanate-based ceramic. These ceramic forms will be encapsulated within canisters containing high level waste glass for geologic disposal. Process development work is being conducted with sub-scale, process prototypic equipment. Final validation of the process will be done using actual plutonium material and functionally prototypic equipment within a glovebox. Due to the radioactive nature of the material, remote material handling is necessary to reduce the radiation exposure to the operators. A remote operated Material Transfer System to interface with process equipment has been developed.

  19. Container lid gasket protective strip for double door transfer system

    DOEpatents

    Allen, Jr., Burgess M

    2013-02-19

    An apparatus and a process for forming a protective barrier seal along a "ring of concern" of a transfer container used with double door systems is provided. A protective substrate is supplied between a "ring of concern" and a safety cover in which an adhesive layer of the substrate engages the "ring of concern". A compressive foam strip along an opposite side of the substrate engages a safety cover such that a compressive force is maintained between the "ring of concern" and the adhesive layer of the substrate.

  20. Radiative interactions in transient energy transfer in gaseous systems

    NASA Technical Reports Server (NTRS)

    Tiwari, S. N.

    1985-01-01

    Analyses and numerical procedures are presented to investigate the radiative interactions in transient energy transfer processes in gaseous systems. The nongray radiative formulations are based on the wide-band model correlations for molecular absorption. Various relations for the radiative flux are developed; these are useful for different flow conditions and physical problems. Specific plans for obtaining extensive results for different cases are presented. The methods presented in this study can be extended easily to investigate the radiative interactions in realistic flows of hydrogen-air species in the scramjet engine.

  1. Energy Transfer in the Earth-Sun System

    NASA Astrophysics Data System (ADS)

    Lui, A. T. Y.; Kamide, Y.

    2007-02-01

    Conference on Earth-Sun System Exploration: Energy Transfer; Kailua-Kona, Hawaii, USA, 16-20 January 2006; The goal of this conference, which was supported by several agencies and organizations, was to provide a forum for physicists engaged in the Earth-Sun system as well as in laboratory experiments to discuss and exchange knowledge and ideas on physical processes involving energy transfer. The motivation of the conference stemmed from the following realization: Space assets form an important fabric of our society, performing functions such as television broadcasting, cell- phone communication, navigation, and remote monitoring of tropospheric weather. There is increasing awareness of how much our daily activities can be adversely affected by space disturbances stretching all the way back to the Sun. In some of these energetic phenomena, energy in various forms can propagate long distances from the solar surface to the interplanetary medium and eventually to the Earth's immediate space environment, namely, its magnetosphere, ionosphere, and thermosphere. In addition, transformation of energy can take place in these space disturbances, allowing charged-particle energy to be transformed to electromagnetic energy or vice versa. In- depth understanding of energy transformation and transmission in the Earth-Sun system will foster the identification of physical processes responsible for space disturbances and the prediction of their occurrences and effects. Participants came from 15 countries.

  2. Technology Adoption: an Interaction Perspective

    NASA Astrophysics Data System (ADS)

    Sitorus, Hotna M.; Govindaraju, Rajesri; Wiratmadja, I. I.; Sudirman, Iman

    2016-02-01

    The success of a new technology depends on how well it is accepted by its intended users. Many technologies face the problem of low adoption rate, despite the benefits. An understanding of what makes people accept or reject a new technology can help speed up the adoption rate. This paper presents a framework for technology adoption based on an interactive perspective, resulting from a literature study on technology adoption. In studying technology adoption, it is necessary to consider the interactions among elements involved in the system, for these interactions may generate new characteristics or new relationships. The interactions among elements in a system adoption have not received sufficient consideration in previous studies of technology adoption. Based on the proposed interaction perspective, technology adoption is elaborated by examining interactions among the individual (i.e. the user or prospective user), the technology, the task and the environment. The framework is formulated by adopting several theories, including Perceived Characteristics of Innovating, Diffusion of Innovation Theory, Technology Acceptance Model, Task-Technology Fit and usability theory. The proposed framework is illustrated in the context of mobile banking adoption. It is aimed to offer a better understanding of determinants of technology adoption in various contexts, including technology in manufacturing systems.

  3. Thermodynamic aspects of information transfer in complex dynamical systems.

    PubMed

    Cafaro, Carlo; Ali, Sean Alan; Giffin, Adom

    2016-02-01

    From the Horowitz-Esposito stochastic thermodynamical description of information flows in dynamical systems [J. M. Horowitz and M. Esposito, Phys. Rev. X 4, 031015 (2014)], it is known that while the second law of thermodynamics is satisfied by a joint system, the entropic balance for the subsystems is adjusted by a term related to the mutual information exchange rate between the two subsystems. In this article, we present a quantitative discussion of the conceptual link between the Horowitz-Esposito analysis and the Liang-Kleeman work on information transfer between dynamical system components [X. S. Liang and R. Kleeman, Phys. Rev. Lett. 95, 244101 (2005)]. In particular, the entropic balance arguments employed in the two approaches are compared. Notwithstanding all differences between the two formalisms, our work strengthens the Liang-Kleeman heuristic balance reasoning by showing its formal analogy with the recent Horowitz-Esposito thermodynamic balance arguments. PMID:26986295

  4. Strengthening Adoption Practice, Listening to Adoptive Families

    ERIC Educational Resources Information Center

    Atkinson, Anne; Gonet, Patricia

    2007-01-01

    In-depth interviews with 500 adoptive families who received postadoption services through Virginia's Adoptive Family Preservation (AFP) program paint a richly detailed picture of the challenges adoptive families face and what they need to sustain adoption for many years after finalization. Findings document the need for support in a variety of…

  5. Recalibrating the BC Transfer System: Findings from the Consultation. Special Report, June 2007

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2007

    2007-01-01

    In November 2005, the BC Council on Admissions and Transfer launched a consultation, Recalibrating the BC Transfer System, motivated by significant changes in the BC post-secondary system over the last decade and concern that these changes had not resulted in concomitant adjustments in the structure of the BC Transfer System or the BC Transfer…

  6. Italian National Galileo Telescope (TNG) control system: hardware, software, and methods adopted to improve the performance of the fully digital drive system

    NASA Astrophysics Data System (ADS)

    Mancini, Dario

    1995-06-01

    The new generation telescopes need very high quality and reliable control systems in order to guarantee the quality and continuity of the service requested by the high cost of scientific observations. Telescopes require many years to be developed and sometimes they appear to be obsolete at the first light. For this reason many efforts are to be made in terms of technical management allowing telescopes to reach the first light in the shortest possible time, rejecting any technical obsolescence phenomenon. This paper is a general overview on the technical management approach, and contemporarily a description of the solutions adopted to improve the TNG digital drive system capabilities and reliability.

  7. Adoptive T-cell therapy.

    PubMed

    Lokhorst, H M; Liebowitz, D

    1999-01-01

    Adoptive immunotherapy, or the transfer of immunocompetent cells, has been shown to be a promising new strategy for treatment of a variety of malignancies, including leukemia and non-Hodgkin's lymphoma. The possibility that it may likewise benefit patients with multiple myeloma is now being explored by researchers in Europe and the United States. Two alternatives, one using donor leukocyte infusions (DLIs) and the other using autologous T cells, are described. In the Netherlands, researchers studied the use of DLIs in 17 patients with multiple myeloma who relapsed after bone marrow transplant (BMT). Of 16 evaluable patients, 10 (62%) responded, with six (37%) achieving a complete response (CR). After a median follow-up duration of 28 months, five patients relapsed and five remained in remission. Graft-versus-host disease (GVHD) developed in nine patients. In the United States, adoptive immunotherapy is currently being tested in eight patients with chemotherapy-resistant lymphoma. Autologous T cells were obtained prior to BMT and expanded using an anti-CD3/CD28 culture system. After BMT, the cells were reinfused into the patient. At approximately day 14, granulocyte levels began to recover in the six evaluable patients, and levels remained relatively stable over the posttreatment course. Two patients developed severe autoimmune toxicity, which responded to treatment in one and resolved spontaneously in the other. PMID:9989486

  8. Role and Scope of the Montana University System. Adopted June 25, 1979 by the Board of Regents, Montana University System.

    ERIC Educational Resources Information Center

    Montana State Office of the Commissioner of Higher Education, Helena.

    The role and scope of the Montana University and postsecondary education system are described. It is explained that the primary goal of the Montana University System is to use as effectively as possible the resources available to it in providing high quality educational opportunities and service to the people of the state, encompassing the three…

  9. Design of Frame-transferred Surface Array CCD Imaging System for Dark Objects

    NASA Astrophysics Data System (ADS)

    Zhang, Yu-heng; Yan, Yi-hua

    2016-01-01

    In order to realize the requirement of low-noise observations of dark objects in deep-space explorations, the design method for a simple and stable space camera imaging system is proposed in this paper. Based on the back-illuminated frame-transferred surface array CCD (CCD47-20AIMO) produced by the British E2V company, the circuitry design is given for the every part of the system. In which the applications of the correlated double-sampling analog-digital converter (AD) and the synchronous dynamic random access memory (SDRAM) can effectively suppress the correlated noise in the image signal. In addition, a drive control method favorable to the adjustment of exposure time is proposed, in the light-sensing stage it provides the exposure time with an independent and adjustable time delay to make the imaging system satisfy the requirement of long exposure time setting. The imaging system adopts the Cyclone III-series EP3C25Q240C8 field programable gate array produced by the Altera company as the kernel control device, and the drives are programmed in modules according to the function of the every device, in favor of transplantation. The simulative and experimental results indicate that the drive circuitry works normally, and that the system design can satisfy the preset requirement.

  10. Medical Issues in Adoption

    MedlinePlus

    ... to Know About Zika & Pregnancy Medical Issues in Adoption KidsHealth > For Parents > Medical Issues in Adoption Print ... or emotional abuse of the child continue Agency Adoptions If you adopt through an agency, you might ...

  11. Dynamic entanglement transfer in a double-cavity optomechanical system

    NASA Astrophysics Data System (ADS)

    Huan, Tiantian; Zhou, Rigui; Ian, Hou

    2015-08-01

    We give a theoretical study of a double-cavity system in which a mechanical resonator beam is coupled to two cavity modes on both sides through radiation pressures. The indirect coupling between the cavities via the resonator sets up a correlation in the optomechanical entanglements between the two cavities with the common resonator. This correlation initiates an entanglement transfer from the intracavity photon-phonon entanglements to an intercavity photon-photon entanglement. Using numerical solutions, we show two distinct regimes of the optomechanical system, in which the indirect entanglement either builds up and eventually saturates or undergoes a death-and-revival cycle, after a time lapse for initiating the cooperative motion of the left and right cavity modes.

  12. A technology transfer tracking system for NREL: Overview and results

    SciTech Connect

    Chapman, R.L.; Chapman, M.J.

    1996-07-01

    The purpose of this study has been to assess the National Renewable Energy Laboratory`s (NREL) technology, transfer--both the activities and the system, with the objective of developing a system to track the benefits of NREL-sponsored or conducted research. There were two factors which facilitated this study and which were important in the ability to make a detailed analysis and series of recommendations. First, was the nature of the lab, being one which, from its beginning, has worked closely with industry and, therefore has been directed toward research which would be of value to industry and hopefully commercialized. Second, the size of the laboratory made it relatively more easy to address issues and to become familiar with the organization and with the scientists themselves.

  13. Heat transfer analysis for peripheral blood flow measurement system

    NASA Astrophysics Data System (ADS)

    Nagata, Koji; Hattori, Hideharu; Sato, Nobuhiko; Ichige, Yukiko; Kiguchi, Masashi

    2009-06-01

    Some disorders such as circulatory disease and metabolic abnormality cause many problems to peripheral blood flow condition. Therefore, frequent measurement of the blood flow condition is bound to contribute to precaution against those disorders and to control of conditions of the diseases. We propose a convenient means of blood flow volume measurement at peripheral part, such as fingertips. Principle of this measurement is based on heat transfer characteristics of peripheral part containing the blood flow. Transition response analysis of skin surface temperature has provided measurement model of the peripheral blood flow volume. We developed the blood flow measurement system based on that model and evaluated it by using artificial finger under various temperature conditions of ambience and internal fluid. The evaluation results indicated that proposed method could estimate the volume of the fluid regardless of temperature condition of them. Finally we applied our system to real finger testing and have obtained results correlated well with laser Doppler blood flow meter values.

  14. Dry transfer system for spent fuel: Project report, A system designed to achieve the dry transfer of bare spent fuel between two casks. Final report

    SciTech Connect

    Dawson, D.M.; Guerra, G.; Neider, T.; Shih, P.

    1995-12-01

    This report describes the system developed by EPRI/DOE for the dry transfer of spent fuel assemblies outside the reactor spent fuel pool. The system is designed to allow spent fuel assemblies to be removed from a spent fuel pool in a small cask, transported to the transfer facility, and transferred to a larger cask, either for off-site transportation or on-site storage. With design modifications, this design is capable of transferring single spent fuel assemblies from dry storage casks to transportation casks or visa versa. One incentive for the development of this design is that utilities with limited lifting capacity or other physical or regulatory constraints are limited in their ability to utilize the current, more efficient transportation and storage cask designs. In addition, DOE, in planning to develop and implement the multi-purpose canister (MPC) system for the Civilian Radioactive Waste Management System, included the concept of an on-site dry transfer system to support the implementation of the MPC system at reactors with limitations that preclude the handling of the MPC system transfer casks. This Dry Transfer System can also be used at reactors wi decommissioned spent fuel pools and fuel in dry storage in non-MPC systems to transfer fuel into transportation casks. It can also be used at off-reactor site interim storage facilities for the same purpose.

  15. A novel high-heat transfer low-NO{sub x} natural gas combustion system. Phase 1 final report

    SciTech Connect

    Rue, D.M.; Fridman, A.; Viskanta, R.; Neff, D.

    1997-11-01

    Phase I of the project focused on acquiring the market needs, modeling, design, and test plan information for a novel high-heat transfer low-NO{sub x} natural gas combustion system. All goals and objectives were achieved. The key component of the system is an innovative burner technology which combines high temperature natural gas preheating with soot formation and subsequent soot burnout in the flame, increases the system`s energy efficiency and furnace throughput, while minimizing the furnace air emissions, all without external parasitic systems. Work has included identifying industry`s needs and constraints, modeling the high luminosity burner system, designing the prototype burner for initial laboratory-scale testing, defining the test plan, adapting the burner technology to meet the industry`s needs and constraints, and outlining the Industrial Adoption Plan.

  16. The Use of Video in Knowledge Transfer of Teacher-Led Psychosocial Interventions: Feeling Competent to Adopt a Different Role in the Classroom (L'utilisation de la vidéo dans le transfert de connaissances dans les interventions psychosociales menées par les enseignants : sentir que l'on a la compétence d'adopter un rôle différent dans la salle de classe)

    ERIC Educational Resources Information Center

    Beauregard, Caroline; Rousseau, Cécile; Mustafa, Sally

    2015-01-01

    Because they propose a form of modeling, videos have been recognised to be useful to transfer knowledge about practices requiring teachers to adopt a different role. This paper describes the results of a satisfaction survey with 98 teachers, school administrators and professionals regarding their appreciation of training videos showing teacher-led…

  17. Apparatus and Method for Effecting Data Transfer Between Data Systems

    NASA Technical Reports Server (NTRS)

    Kirkpatrick, Joey V. (Inventor); Grosz, Francis B., Jr. (Inventor); Lannes, Kenny (Inventor); Maniscalco, David G. (Inventor)

    2001-01-01

    An apparatus for effecting data transfer between data systems comprising a first transceiver and a second transceiver. The first transceiver has an input for receiving digital data from one of the data systems, an output for serially outputting digital data to one of the data systems, at least one transmitter for converting digital data received at the input into optical signals, and at least one receiver for receiving optical signals and serially converting the received optical signals to digital data for output to the data output. The second transceiver has an input for receiving digital data from another one of the data systems, an output for serially outputting digital data to the another one of the data systems, at least one transmitter for serially converting digital data received at the input of the second transceiver into optical signals, and at least one receiver for receiving optical signals and serially converting the received optical signals to digital data for output to the output of the second transceiver. The apparatus further comprises an optical link connecting the first and second transceivers. The optical link comprising a pair of optical fibers. One of the optical fibers optically links the transmitter of the first transceiver to the receiver of the second transceiver. The other optical fiber optically links the receiver of the first transceiver to the transmitter of the second transceiver.

  18. Using the Diffusion of Innovation Theory to Explain the Degree of English Teachers' Adoption of Interactive Whiteboards in the Modern Systems School in Jordan: A Case Study

    ERIC Educational Resources Information Center

    Jwaifell, Mustafa; Gasaymeh, Al-Mothana

    2013-01-01

    This study aimed to explain the use of interactive whiteboards (IWBs) by English female teachers in Modern Systems School in Jordan. Viewed from the lens of Rogers' Diffusion of Innovation Theory, the study examined and reported teachers' use of IWB and its features that have impact on their decisions to adopt it in Modern Systems School . The…

  19. Heat transfer in vacuum packaged microelectromechanical system devices

    NASA Astrophysics Data System (ADS)

    Cai, Chunpei

    2008-01-01

    This study analyzes heat transfer effects inside vacuum packaged microelectromechanical system (MEMS) devices. A packaged device is simplified as four plates forming a square cavity, the bottom plate represents a hot chip, while the other three plates are maintained at room temperature. For a highly rarefied free molecular internal gas flow scenario, the corresponding detailed density and temperature fields are analytically determined with a proposed speculation. This speculation indicates that for a steady free molecular gas flow inside a convex closure domain formed by walls maintained at different temperatures: (1) the velocity distribution functions for those molecules diffusely reflected at different walls and traveling away from them are Maxwellian with different number densities; (2) for each distribution, ni√Ti is a constant, where ni is the number density for the group of reflected molecules, and Ti is the temperature for the ith plate. For a near continuum flow scenario, the governing energy equation degenerates to Laplace's equation with several temperature-jump wall boundary conditions. This study also includes discussions and comparisons among analytical results, simulation results from the direct simulation Monte Carlo method, and results by solving the Navier-Stokes equations with proper wall boundary conditions. The approach used in this study is generally applicable to study internal flows and heat transfer effects in other vacuum packaged MEMS devices with different shapes.

  20. Credit Transfer: Models and Systems in BC, North America and beyond. Special Report

    ERIC Educational Resources Information Center

    Finlay, Finola

    2009-01-01

    Many jurisdictions have implemented new models of transfer, building on the bedrock of course-to-course articulation, in attempts to address mobility issues and ease transfer for students. The British Columbia (BC) postsecondary system has in the past considered proposals for new models of transfer. System-wide consultations have resulted in the…

  1. Adoptive transfer of CD4(+)Foxp3(+) regulatory T cells to C57BL/6J mice during acute infection with Toxoplasma gondii down modulates the exacerbated Th1 immune response.

    PubMed

    Olguín, Jonadab E; Fernández, Jacquelina; Salinas, Nohemí; Juárez, Imelda; Rodriguez-Sosa, Miriam; Campuzano, Jaime; Castellanos, Carlos; Saavedra, Rafael

    2015-08-01

    Infection of C57BL/6J mice with the parasite Toxoplasma gondii triggers a powerful Th1 immune response that is detrimental to the host. During acute infection, a reduction in CD4(+)Foxp3(+) regulatory T cells (Treg) has been reported. We studied the role of Treg during T. gondii infection by adoptive transfer of cells purified from transgenic Foxp3(EGFP) mice to infected wild type animals. We found a less severe weight loss, a significant delayed mortality in infected Treg-transferred mice, and reduced pathology of the small intestine that were associated with lower IFN-γ and TNF-α levels. Nevertheless, higher cyst number and parasite load in brain were observed in these mice. Treg-transferred infected mice showed reduced levels of both IFN-γ and TNF-α in sera. A reduced number of CD4(+) T cells producing IFN-γ was detected in these mice, while IL-2 producing CD4(+) T cells were restored to levels nearly similar to uninfected mice. CD25 and CD69 expression of CD4(+) T cells were also down modulated. Our data show that the low Treg cell number are insufficient to modulate the activation of CD4(+) T cells and the production of high levels of IFN-γ. Thus, a delicate balance between an optimal immune response and its modulation by Treg cells must exist. PMID:25899946

  2. The Adoption of Electronic Benefit Transfer Card for Delivering Food Stamp Benefits in Alabama: Perceptions of College Students Participating in the Food Stamp Program

    ERIC Educational Resources Information Center

    Zekeri, Andrew A.

    2004-01-01

    The reasons for moving from paper coupons to delivering food stamps electronically include potential reduction in the cost of administering the system and in fraud, theft and abuse of the system. Furthermore, the use of EBT is believed o reduce social stigma and embarrassment felt by recipients when using paper coupon. Therefore, using survey data…

  3. The Magsat three axis arc second precision attitude transfer system

    NASA Technical Reports Server (NTRS)

    Schenkel, F. W.; Heins, R. J.

    1981-01-01

    The Magsat Attitude Transfer System (ATS), which provides attitude alteration in pitch, yaw, and roll is described. A remote vector magnetometer extends from Magsat on a 20 ft boom, requiring vector orientation by reference to coordinate axes determined by a set of star mapping cameras. The ATS was designed to perform in a solar illuminated environment by using an optically narrow bandwidth with synchronous demodulation at 9300 A. The pitch/yaw optical design, the electrooptics, and signal and switching diagrams are provided. Simple mirrors with no moving parts are placed on the magnetometer to reflect a collimated beam from the ATS for attitude indication, which is accurate to one part in 96. Alignment was completed within 24 hr after launch.

  4. Energy transfer in real and artificial photosynthetic systems

    SciTech Connect

    Hunt, J.E.; Katz, J.J.; Hindman, J.C.

    1984-01-01

    A comparative study of the fluorescence emitted by three photosynthetic organisms (chlorella, tribonema, and anacystis) and the fluorescence of some model systems selected for study by criteria described below are reported. Light emission has been studied as a function of excitation wavelength and of temperature. Low temperature fluorescence studies on photosynthetic organisms and chloroplast preparations provide the chief experimental support for the existence of a PSII in green plants, and fluorescence at low temperatures has been used as the principal source of information on energy flow between the photosynthetic pigments. The nature and functional aspects of PSII and the course of energy transfer in the photosynthetic apparatus are highly pertinent to the oxygen evolution in green plant photosynthesis.

  5. 2D and 3D Mass Transfer Simulations in β Lyrae System

    NASA Astrophysics Data System (ADS)

    Nazarenko, V. V.; Glazunova, L. V.; Karetnikov, V. G.

    2001-12-01

    2D and 3D mass transfer simulations of the mass transfer in β Lyrae binary system. We have received that from a point L3 40 per cent of mass transfer from L1-point is lost.The structure of a gas envelope, around system is calculated.3-D mass transfer simulations has shown presence the spiral shock in the disk around primary star's and a jet-like structures (a mass flow in vertical direction) over a stream.

  6. Secure Data Transfer Guidance for Industrial Control and SCADA Systems

    SciTech Connect

    Mahan, Robert E.; Fluckiger, Jerry D.; Clements, Samuel L.; Tews, Cody W.; Burnette, John R.; Goranson, Craig A.; Kirkham, Harold

    2011-09-01

    This document was developed to provide guidance for the implementation of secure data transfer in a complex computational infrastructure representative of the electric power and oil and natural gas enterprises and the control systems they implement. For the past 20 years the cyber security community has focused on preventative measures intended to keep systems secure by providing a hard outer shell that is difficult to penetrate. Over time, the hard exterior, soft interior focus changed to focus on defense-in-depth adding multiple layers of protection, introducing intrusion detection systems, more effective incident response and cleanup, and many other security measures. Despite much larger expenditures and more layers of defense, successful attacks have only increased in number and severity. Consequently, it is time to re-focus the conventional approach to cyber security. While it is still important to implement measures to keep intruders out, a new protection paradigm is warranted that is aimed at discovering attempted or real compromises as early as possible. Put simply, organizations should take as fact that they have been, are now, or will be compromised. These compromises may be intended to steal information for financial gain as in the theft of intellectual property or credentials that lead to the theft of financial resources, or to lie silent until instructed to cause physical or electronic damage and/or denial of services. This change in outlook has been recently confirmed by the National Security Agency [19]. The discovery of attempted and actual compromises requires an increased focus on monitoring events by manual and/or automated log monitoring, detecting unauthorized changes to a system's hardware and/or software, detecting intrusions, and/or discovering the exfiltration of sensitive information and/or attempts to send inappropriate commands to ICS/SCADA (Industrial Control System/Supervisory Control And Data Acquisition) systems.

  7. Thermodynamic aspects of information transfer in complex dynamical systems

    NASA Astrophysics Data System (ADS)

    Cafaro, Carlo; Ali, Sean Alan; Giffin, Adom

    2016-02-01

    From the Horowitz-Esposito stochastic thermodynamical description of information flows in dynamical systems [J. M. Horowitz and M. Esposito, Phys. Rev. X 4, 031015 (2014), 10.1103/PhysRevX.4.031015], it is known that while the second law of thermodynamics is satisfied by a joint system, the entropic balance for the subsystems is adjusted by a term related to the mutual information exchange rate between the two subsystems. In this article, we present a quantitative discussion of the conceptual link between the Horowitz-Esposito analysis and the Liang-Kleeman work on information transfer between dynamical system components [X. S. Liang and R. Kleeman, Phys. Rev. Lett. 95, 244101 (2005), 10.1103/PhysRevLett.95.244101]. In particular, the entropic balance arguments employed in the two approaches are compared. Notwithstanding all differences between the two formalisms, our work strengthens the Liang-Kleeman heuristic balance reasoning by showing its formal analogy with the recent Horowitz-Esposito thermodynamic balance arguments.

  8. IL-2 / α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment

    PubMed Central

    Mahr, Benedikt; Unger, Lukas; Hock, Karin; Pilat, Nina; Baranyi, Ulrike; Schwarz, Christoph; Maschke, Svenja; Farkas, Andreas Michael; Wekerle, Thomas

    2016-01-01

    Cell therapy with recipient Tregs achieves engraftment of allogeneic bone marrow (BM) without the need for cytoreductive conditioning (i.e., without irradiation or cytotoxic drugs). Thereby mixed chimerism and transplantation tolerance are established in recipients conditioned solely with costimulation blockade and rapamycin. However, clinical translation would be substantially facilitated if Treg-stimulating pharmaceutical agents could be used instead of individualized cell therapy. Recently, it was shown that interleukin-2 (IL-2) complexed with a monoclonal antibody (mAb) (clone JES6-1A12) against IL-2 (IL-2 complexes) potently expands and activates Tregs in vivo. Therefore, we investigated whether IL-2 complexes can replace Treg therapy in a costimulation blockade-based and irradiation-free BM transplantation (BMT) model. Unexpectedly, the administration of IL-2 complexes at the time of BMT (instead of Tregs) failed to induce BM engraftment in non-irradiated recipients (0/6 with IL-2 complexes vs. 3/4 with Tregs, p<0.05). Adding IL-2 complexes to an otherwise effective regimen involving recipient irradiation (1Gy) but no Treg transfer indeed actively triggered donor BM rejection at higher doses (0/8 with IL-2 complexes vs. 9/11 without, p<0.01) and had no detectable effect at two lower doses (3/5 vs. 9/11, p>0.05). CD8 T cells and NK cells of IL-2 complex-treated naïve mice showed an enhanced proliferative response towards donor antigens in vitro despite the marked expansion of Tregs. However, IL-2 complexes also expanded conventional CD4 T cells, CD8 T cells, NK cells, NKT cells and notably even B cells, albeit to a lesser extent. Notably, IL-2 complex expanded Tregs featured less potent suppressive functions than in vitro activated Tregs in terms of T cell suppression in vitro and BM engraftment in vivo. In conclusion, these data suggest that IL-2 complexes are less effective than recipient Tregs in promoting BM engraftment and in contrast actually trigger BM

  9. IL-2/α-IL-2 Complex Treatment Cannot Be Substituted for the Adoptive Transfer of Regulatory T cells to Promote Bone Marrow Engraftment.

    PubMed

    Mahr, Benedikt; Unger, Lukas; Hock, Karin; Pilat, Nina; Baranyi, Ulrike; Schwarz, Christoph; Maschke, Svenja; Farkas, Andreas Michael; Wekerle, Thomas

    2016-01-01

    Cell therapy with recipient Tregs achieves engraftment of allogeneic bone marrow (BM) without the need for cytoreductive conditioning (i.e., without irradiation or cytotoxic drugs). Thereby mixed chimerism and transplantation tolerance are established in recipients conditioned solely with costimulation blockade and rapamycin. However, clinical translation would be substantially facilitated if Treg-stimulating pharmaceutical agents could be used instead of individualized cell therapy. Recently, it was shown that interleukin-2 (IL-2) complexed with a monoclonal antibody (mAb) (clone JES6-1A12) against IL-2 (IL-2 complexes) potently expands and activates Tregs in vivo. Therefore, we investigated whether IL-2 complexes can replace Treg therapy in a costimulation blockade-based and irradiation-free BM transplantation (BMT) model. Unexpectedly, the administration of IL-2 complexes at the time of BMT (instead of Tregs) failed to induce BM engraftment in non-irradiated recipients (0/6 with IL-2 complexes vs. 3/4 with Tregs, p<0.05). Adding IL-2 complexes to an otherwise effective regimen involving recipient irradiation (1Gy) but no Treg transfer indeed actively triggered donor BM rejection at higher doses (0/8 with IL-2 complexes vs. 9/11 without, p<0.01) and had no detectable effect at two lower doses (3/5 vs. 9/11, p>0.05). CD8 T cells and NK cells of IL-2 complex-treated naïve mice showed an enhanced proliferative response towards donor antigens in vitro despite the marked expansion of Tregs. However, IL-2 complexes also expanded conventional CD4 T cells, CD8 T cells, NK cells, NKT cells and notably even B cells, albeit to a lesser extent. Notably, IL-2 complex expanded Tregs featured less potent suppressive functions than in vitro activated Tregs in terms of T cell suppression in vitro and BM engraftment in vivo. In conclusion, these data suggest that IL-2 complexes are less effective than recipient Tregs in promoting BM engraftment and in contrast actually trigger BM

  10. The Booster to AGS beam transfer fast kicker systems

    SciTech Connect

    Zhang, W.; Bunicci, J.; Soukas, A.V.; Zhang, S.Y.

    1992-01-01

    The Brookhaven AGS Booster has a very successful commissioning period in June 1991. The third phase of that commissioning was a beam extraction test. The Booster extraction fast kicker (F3) deflected a 1.2 GeV proton beam from the Booster circulating orbit into the extraction septum aperture, partially down the extraction line to a temporary beam stop. Now, the Booster is committed to the AGS operations program for both heavy ion and proton beams. Thus, the Booster extraction and the corresponding AGS injection systems must operate routinely up to a pulse repetition frequency of 7.5 Hertz, and up to a beam energy of 1.5 Gev. The injection fast kicker is located in the A5 section of the AGS ring and is used to deflect the proton or heavy ion beam into its final AGS closed orbit. A distinctive feature of the AGS injection fast kicker modulators is the tail-bitting function required for proton beam injection. This enables the system to produce a fast current fall time to go along with the high current pulse amplitude with a fast rise time. The AGS injection fast kicker system has three pulse modulators, and each modulator consists of two thyratrons. The main PFN thyratrons switch on the current, and the tail bitting thyratrons are used to force the magnet current to decrease rapidly. Two digital pulse delay generators are used to align the main thyratrons and the tail bitting thyratrons respectively. The system has been tested and installed. The final commissioning of the Booster to AGS beam transfer line and injection is currently being undertaken. In this article, the system design, realization techniques and performance data will be presented.

  11. The Booster to AGS beam transfer fast kicker systems

    SciTech Connect

    Zhang, W.; Bunicci, J.; Soukas, A.V.; Zhang, S.Y.

    1992-08-01

    The Brookhaven AGS Booster has a very successful commissioning period in June 1991. The third phase of that commissioning was a beam extraction test. The Booster extraction fast kicker (F3) deflected a 1.2 GeV proton beam from the Booster circulating orbit into the extraction septum aperture, partially down the extraction line to a temporary beam stop. Now, the Booster is committed to the AGS operations program for both heavy ion and proton beams. Thus, the Booster extraction and the corresponding AGS injection systems must operate routinely up to a pulse repetition frequency of 7.5 Hertz, and up to a beam energy of 1.5 Gev. The injection fast kicker is located in the A5 section of the AGS ring and is used to deflect the proton or heavy ion beam into its final AGS closed orbit. A distinctive feature of the AGS injection fast kicker modulators is the tail-bitting function required for proton beam injection. This enables the system to produce a fast current fall time to go along with the high current pulse amplitude with a fast rise time. The AGS injection fast kicker system has three pulse modulators, and each modulator consists of two thyratrons. The main PFN thyratrons switch on the current, and the tail bitting thyratrons are used to force the magnet current to decrease rapidly. Two digital pulse delay generators are used to align the main thyratrons and the tail bitting thyratrons respectively. The system has been tested and installed. The final commissioning of the Booster to AGS beam transfer line and injection is currently being undertaken. In this article, the system design, realization techniques and performance data will be presented.

  12. Optical Power Transfer System for Powering a Remote Mobility System for Multiple Missions

    NASA Technical Reports Server (NTRS)

    Stone, William C. (Inventor); Hogan, Bartholomew P. (Inventor)

    2016-01-01

    An optical power transfer system for powering a remote mobility system for multiple missions comprising a high power source and a chilling station connected to a laser source. The laser source transmits a high optical energy to a beam switch assembly via an optical fiber. The beam switch assembly is optically connected to actively cooled fiber spoolers. Docking stations are adapted for securing the fiber spoolers until alternatively ready for use by a remote mobility system. The remote mobility system is optically connected to the fiber spoolers and has a receiving port adapted for securing the fiber spoolers thereon. The fiber spooler transmits the optical energy to a power conversion system which converts the optical energy received to another usable form of energy. More than one power source may be used where the remote mobility system transfers from one source to another while maintaining an operational radius to each source.

  13. Ultrafast charge transfer processes in ordered molecular systems

    NASA Astrophysics Data System (ADS)

    Olson, Eric James Crane

    1998-11-01

    optical microscopy (NSOM) are used in conjunction with bulk absorption and fluorescence measurements to correlate the morphological and photophysical properties of titanyl phthalocyanine/perylene phenethylimide (TiOPc/PPEI) bilayer systems. Steady-state fluorescence intensity and fluorescence lifetime measurements are used as a measure of interfacial charge-transfer quenching efficiencies.

  14. BPM SYSTEM FOR THE SNS RING AND TRANSFER LINES.

    SciTech Connect

    DAWSON,W.C.; CAMERON,P.; CERNIGLIA,P.; CUPOLO,J.; DEGEN,C.; DELLAPENNA,A.; HUHN,A.; KESSELMAN,M.; MEAD,J.; SIKORA,R.

    2002-05-06

    The Spallation Neutron Source Ring accumulates about 1060 pulses of 38mA peak current IGeV H-minus particles from the Linac thru the HEBT line, then delivers this accumulated beam in a single pulse to the mercury target via the RTBT line. Bunching frequency of beam in the HEBT line is 402.5MHz, and about 1MHz in the Ring and RTBT. Position monitor electrodes in HEBT are of the shorted stripline type, with apertures of 12cm except in the dispersive bend, where the aperture is 21cm. Ring and RTBT electrodes are open striplines, with apertures of 21, 26, 30, and 36cm. All pickups are dual plane. The electronics will be PC-based with the Analog/Digital Front End passing data and receiving control and timing thru a custom PC1 interface developed by LANL[l]. LabVIEW will be used to direct the acquisition, process the data, and transfer results via Ethernet to the EPICS control system. To handle the dynamic range required with well over 60dB variation in signal size, the Ring and RTBT electronics will employ a fast gain switching technique that will take advantage of the 300ns tail-to-head gap to provide position measurement during the entire accumulation cycle. Beam-based alignment will be utilized as part of the system calibration.

  15. BPM System for the SNS Ring and Transfer Lines

    NASA Astrophysics Data System (ADS)

    Dawson, W. C.; Cameron, P.; Cerniglia, P.; Cupolo, J.; Degen, C.; DellaPenna, A.; Huhn, A.; Kesselman, M.; Mead, J.; Sikora, R.

    2002-12-01

    The Spallation Neutron Source Ring accumulates about 1060 pulses of 38mA peak current 1GeV H-minus particles from the Linac thru the HEBT line, then delivers this accumulated beam in a single pulse to the mercury target via the RTBT line. Bunching frequency of beam in the HEBT line is 402.5MHz, and about 1MHz in the Ring and RTBT. Position monitor electrodes in HEBT are of the shorted stripline type, with apertures of 12cm except in the dispersive bend, where the aperture is 21cm. Ring and RTBT electrodes are open striplines, with apertures of 21, 26, 30, and 36cm. All pickups are dual plane. The electronics will be PC-based with the Analog/Digital Front End passing data and receiving control and timing thru a custom PCI interface developed by LANL[1]. LabVIEW will be used to direct the acquisition, process the data, and transfer results via Ethernet to the EPICS control system. To handle the dynamic range required with well over 60dB variation in signal size, the Ring and RTBT electronics will employ a fast gain switching technique that will take advantage of the 300ns tail-to-head gap to provide position measurement during the entire accumulation cycle. Beam-based alignment will be utilized as part of the system calibration.

  16. Demonstration of the smart crane ammunition transfer system

    SciTech Connect

    Bradley, E.C.; Killough, S.M.; Rowe, J.C.

    1996-05-01

    The purpose of the Smart Crane Ammunition Transfer System (SCATS) project is to demonstrate robotic/telerobotic controls technology for a mobile articulated crane for missile/munitions handling, delivery, and reload. Missile resupply and reload have been manually intensive operations up to this time. Currently, reload missiles are delivered by truck to the site of the launcher. A crew of four to five personnel reloads the missiles from the truck to the launcher using a hydraulic-powered crane. The missiles are handled carefully for the safety of the missiles and personnel. Numerous steps are required in the reload process and the entire reload operation can take over an hour for some missile systems. Recent US Army directives require the entire operation to be accomplished in a fraction of that time. Current development of SCATS is being based primarily on reloading Patriot missiles. This paper summarizes the current status of the SCATS project at the Oak Ridge National Laboratory (ORNL). Additional information on project background and requirements has been described previously (Bradley, et al., 1995).

  17. Transfer entropy in physical systems and the arrow of time.

    PubMed

    Spinney, Richard E; Lizier, Joseph T; Prokopenko, Mikhail

    2016-08-01

    Recent developments have cemented the realization that many concepts and quantities in thermodynamics and information theory are shared. In this paper, we consider a highly relevant quantity in information theory and complex systems, the transfer entropy, and explore its thermodynamic role by considering the implications of time reversal upon it. By doing so we highlight the role of information dynamics on the nuanced question of observer perspective within thermodynamics by relating the temporal irreversibility in the information dynamics to the configurational (or spatial) resolution of the thermodynamics. We then highlight its role in perhaps the most enduring paradox in modern physics, the manifestation of a (thermodynamic) arrow of time. We find that for systems that process information such as those undergoing feedback, a robust arrow of time can be formulated by considering both the apparent physical behavior which leads to conventional entropy production and the information dynamics which leads to a quantity we call the information theoretic arrow of time. We also offer an interpretation in terms of optimal encoding of observed physical behavior. PMID:27627274

  18. Meeting user needs in national healthcare systems: lessons from early adopter community pharmacists using the electronic prescriptions service

    PubMed Central

    2014-01-01

    Background The Electronic Prescription Service release Two (EPS2) is a new national healthcare information and communication technology in England that aims to deliver effective prescription writing, dispensing and reimbursement service to benefit patients. The aim of the study was to explore initial user experiences of Community Pharmacists (CPs) using EPS2. Methods We conducted nonparticipant observations and interviews in eight EPS2 early adopter community pharmacies classified as ‘first-of-type’ in midlands and northern regions in England. We interviewed eight pharmacists and two dispensers in addition to 56 hours recorded nonparticipant observations as field notes. Line-by-line coding and thematic analysis was conducted on the interview transcripts and field notes. Results CPs faced two types of challenge. The first was to do with missing electronic prescriptions. This was sometimes very disrupting to work practice, but pharmacists considered it a temporary issue resolvable with minor modifications to the system and user familiarity. The second was to do with long term design-specific issues. Pharmacists could only overcome these by using the system in ways not intended by the developers. Some felt that these issues would not exist had ‘real’ users been involved in the initial development. The issues were: 1) printing out electronic prescriptions (tokens) to dispense from for safe dispensing practices and to free up monitors for other uses, 2) logging all dispensing activities with one user’s Smartcard for convenience and use all human resources in the pharmacy, and, 3) problematic interface causing issues with endorsing prescriptions and claiming reimbursements. Conclusions We question if these unintended uses and barriers would have occurred had a more rigorous user-centric principles been applied at the earlier stages of design and implementation of EPS. We conclude that, since modification can occur at the evaluation stage, there is still scope

  19. Adoption and Korea.

    ERIC Educational Resources Information Center

    Chun, Byung Hoon

    1989-01-01

    Because of Korean attitudes towards adoption and other reasons, attempts to promote intracountry adoption have met with limited success, and intercountry adoption is used as an alternative way of meeting children's needs. (RJC)

  20. Adopted Children and Discipline

    MedlinePlus

    ... a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care Communication & Discipline Types of Families Media ... Your Community Healthy Children > Family Life > Family Dynamics > Adoption & Foster Care > Adopted Children & Discipline Family Life Listen ...

  1. Adoption & Foster Care

    MedlinePlus

    ... Children > Family Life > Family Dynamics > Adoption & Foster Care Adoption & Foster Care Article Body ​Each year, many children join families through adoption and foster care. These families may face unique ...

  2. How Organizational Culture as Perceived by Senior Administrators Influences the Adoption of Information Technology Systems in Two 4-Year Public Universities

    ERIC Educational Resources Information Center

    O'Neill, David Edward

    2012-01-01

    The purpose of this study was to investigate the relationship between university culture, organizational characteristics, and central IT systems adoption within two four-year public universities. A qualitative multi-case methodology was used to examine the influence of organizational cultures and characteristics on personal perceptions, actions,…

  3. A Behavioural Approach to Understanding Semi-Subsistence Farmers' Technology Adoption Decisions: The Case of Improved Paddy-Prawn System in Indonesia

    ERIC Educational Resources Information Center

    Sambodo, Leonardo A. A. T.; Nuthall, Peter L.

    2010-01-01

    Purpose: This study traced the origins of subsistence Farmers' technology adoption attitudes and extracted the critical elements in their decision making systems. Design/Methodology/Approach: The analysis was structured using a model based on the Theory of Planned Behaviour (TPB). The role of a "bargaining process" was particularly explored to…

  4. University and Community College Systems of Nevada Report on Articulation and Transfer.

    ERIC Educational Resources Information Center

    Nevada Univ. and Community Coll. System, Reno. Office of the Chancellor.

    This document reports on articulation and transfer in the University and Community College System of Nevada (UCCSN). In 1996, the Board of Regents of UCCSN established guidelines for facilitating transfer students in the transfer process and encouraging completion of an associate's degree. The policy states: (1) that all campuses will enact…

  5. Advanced Life Support Systems: Opportunities for Technology Transfer

    NASA Technical Reports Server (NTRS)

    Fields, B.; Henninger, D.; Ming, D.; Verostko, C. E.

    1994-01-01

    NASA's future missions to explore the solar system will be of long-duration possibly lasting years at a time. Human life support systems will have to operate with very high reliability for these long periods with essentially no resupply from Earth. Such life support systems will make extensive use of higher plants, microorganisms, and physicochemical processes for recycling air and water, processing wastes, and producing food. Development of regenerative life support systems will be a pivotal capability for NASA's future human missions. A fully functional closed loop human life support system currently does not exist and thus represents a major technical challenge for space exploration. Technologies where all life support consumables are recycled have many potential terrestrial applications as well. Potential applications include providing human habitation in hostile environments such as the polar regions or the desert in such a way as to minimize energy expenditures and to minimize negative impacts on those often ecologically-sensitive areas. Other potential applications include production of food and ornamental crops without damaging the environment from fertilizers that contaminate water supplies; removal of trace gas contaminants from tightly sealed, energy-efficient buildings (the so-called sick building syndrome); and even the potential of gaining insight into the dynamics of the Earth's biosphere such that we can better manage our global environment. Two specific advanced life support technologies being developed by NASA, with potential terrestrial application, are the zeoponic plant growth system and the Hybrid Regenerative Water Recovery System (HRWRS). The potential applications for these candidate dual use technologies are quite different as are the mechanisms for transfer. In the case of zeoponics, a variety of commercial applications has been suggested which represent potentially lucrative markets. Also, the patented nature of this product offers

  6. Effect of 1-methyl-D-tryptophan and adoptive transfer of dendritic cells on polymicrobial sepsis induced by cecal content injection.

    PubMed

    Yim, Hong Soon; Choi, Kyung Min; Kim, Byoungjae; Jung, In Duk; Park, Yeong-Min; Kang, Yoon Kyu; Lee, Min-Goo

    2013-09-01

    A mouse model of polymicrobial sepsis induced by cecal content injection (CCI) was developed with the aim of gaining a better understanding of the mechanism of sepsis. This model has a similar survival pattern to the conventional model with the added benefits of ability to vary the severity of sepsis and greater consistency. Administration of 1-methyl-D-tryptophan (1-MT) to inhibit indoleamine 2,3-dioxygenase (IDO) in mice with CCI-induced sepsis increased the survival rate and tended to up-regulate IL-10/IL-12 serum concentrations. The effectiveness of 1-MT was confirmed by increases in IL-10 over IL-12 in bone marrow-derived dendritic cells (BMDCs) treated with LPS and 1-MT and a superior survival rate 24 hr after injection of these double treated BMDCs in the CCI-induced sepsis model. Therefore, CCI is both a useful and reliable technique for investigating polymicrobial sepsis. The present findings using this newly developed model suggest that inhibition of IDO alleviates the severity of polymicrobial sepsis and modulates the immune response even in cases of severe systemic septic inflammation. PMID:23841524

  7. INTRAMOLECULAR CHARGE AND ENERGY TRANSFER IN MULTICHROMOPHORIC AROMATIC SYSTEMS

    SciTech Connect

    Edward C. Lim

    2008-09-09

    A concerted experimental and computational study of energy transfer in nucleic acid bases and charge transfer in dialkylaminobenzonitriles, and related electron donor-acceptor molecules, indicate that the ultrafast photoprocesses occur through three-state conical interactions involving an intermediate state of biradical character.

  8. The Influence of Transfer System Factors and Training Elapsed Time on Transfer in a Healthcare Organization

    ERIC Educational Resources Information Center

    Mihalko, Beverly J.

    2010-01-01

    Organizations and other sponsors of training face increasing pressure to demonstrate the value or impact of their training programs on individual and organizational performance. A critical element in the validation of training effectiveness is the permanent transfer of learned knowledge, skills, and behaviors to the workplace. The generalization…

  9. Reconceptualizing the Learning Transfer Conceptual Framework: Empirical Validation of a New Systemic Model

    ERIC Educational Resources Information Center

    Kontoghiorghes, Constantine

    2004-01-01

    The main purpose of this study was to examine the validity of a new systemic model of learning transfer and thus determine if a more holistic approach to training transfer could better explain the phenomenon. In all, this study confirmed the validity of the new systemic model and suggested that a high performance work system could indeed serve as…

  10. Improved oxygen mass transfer modeling for diffused or subsurface aeration systems

    SciTech Connect

    McWhirter, J.R.; Hutter, J.C. . Dept. of Chemical Engineering)

    1988-01-01

    The mass transfer analysis of the oxygen transfer performance of diffused air or subsurface mechanical aeration systems has progressed very little over the past twenty years. The ASCE Standard Method for determination of the oxygen mass transfer performance as applied to a diffused or subsurface aeration systems is based on a greatly over-simplified mass transfer model. Although the ASCE Standard can be used to empirically evaluate point performance conditions, it is not suitable for prediction of the performance of diffused aeration systems under changing operating or environmental conditions. A new oxygen mass transfer model has been developed which is a fundamentally more rigorous description of the actual mass transfer process in diffused aeration systems. This model can be confidently used to predict aerator performance under changing operation and environmental conditions and is easily adapted to numerical solution on a computer for routing aeration system performance evaluation as well as process design. The model is presented in this book.

  11. Molten Chloride Salts for Heat Transfer in Nuclear Systems

    NASA Astrophysics Data System (ADS)

    Ambrosek, James Wallace

    2011-12-01

    A forced convection loop was designed and constructed to examine the thermal-hydraulic performance of molten KCl-MgCl2 (68-32 at %) salt for use in nuclear co-generation facilities. As part of this research, methods for prediction of the thermo-physical properties of salt mixtures for selection of the coolant salt were studied. In addition, corrosion studies of 10 different alloys were exposed to the KCl-MgCl2 to determine a suitable construction material for the loop. Using experimental data found in literature for unary and binary salt systems, models were found, or developed to extrapolate the available experimental data to unstudied salt systems. These property models were then used to investigate the thermo-physical properties of the LINO3-NaNO3-KNO 3-Ca(NO3), system used in solar energy applications. Using these models, the density, viscosity, adiabatic compressibility, thermal conductivity, heat capacity, and melting temperatures of higher order systems can be approximated. These models may be applied to other molten salt systems. Coupons of 10 different alloys were exposed to the chloride salt for 100 hours at 850°C was undertaken to help determine with which alloy to construct the loop. Of the alloys exposed, Haynes 230 had the least amount of weight loss per area. Nickel and Hastelloy N performed best based on maximum depth of attack. Inconel 625 and 718 had a nearly uniform depletion of Cr from the surface of the sample. All other alloys tested had depletion of Cr along the grain boundaries. The Nb in Inconel 625 and 718 changed the way the Cr is depleted in these alloys. Grain-boundary engineering (GBE) of Incoloy 800H improved the corrosion resistance (weight loss and maximum depth of attack) by nearly 50% as compared to the as-received Incoloy 800H sample. A high temperature pump, thermal flow meter, and pressure differential device was designed, constructed and tested for use in the loop, The heat transfer of the molten chloride salt was found to

  12. Laser induced forward transfer of SnO2 for sensing applications using different precursors systems

    NASA Astrophysics Data System (ADS)

    Mattle, Thomas; Hintennach, Andreas; Lippert, Thomas; Wokaun, Alexander

    2013-02-01

    This paper presents the transfer of SnO2 by laser induced forward transfer (LIFT) for gas sensor applications. Different donor substrates of SnO2 with and without triazene polymer (TP) as a dynamic release layer were prepared. Transferring these films under different conditions were evaluated by optical microscopy and functionality. Transfers of sputtered SnO2 films do not lead to satisfactory results and transfers of SnO2 nanoparticles are difficult. Transfers of SnO2 nanoparticles can only be achieved when applying a second laser pulse to the already transferred material, which improves the adhesion resulting in a complete pixel. A new approach of decomposing the transfer material during LIFT transfer was developed. Donor films based on UV absorbing metal complex precursors namely, SnCl2(acac)2 were prepared and transferred using the LIFT technique. Transfer conditions were optimized for the different systems, which were deposited onto sensor-like microstructures. The conductivity of the transferred material at temperatures of about 400 ∘C are in a range usable for SnO2 gas sensors. First sensing tests were carried out and the transferred material proved to change conductivity when exposed to ethanol, acetone, and methane.

  13. Systemically transferred hematopoietic stem cells home to the subretinal space and express RPE-65 in a mouse model of retinal pigment epithelium damage.

    PubMed

    Atmaca-Sonmez, Pelin; Li, Yang; Yamauchi, Yasuyuki; Schanie, Carrie L; Ildstad, Suzanne T; Kaplan, Henry J; Enzmann, Volker

    2006-11-01

    Stem cell regeneration of damaged tissue has recently been reported in many different organs. Since the loss of retinal pigment epithelium (RPE) in the eye is associated with a major cause of visual loss - specifically, age-related macular degeneration - we investigated whether hematopoietic stem cells (HSC) given systemically can home to the damaged subretinal space and express markers of RPE lineage. Green fluorescent protein (GFP) cells of bone marrow origin were used in a sodium iodate (NaIO(3)) model of RPE damage in the mouse. The optimal time for adoptive transfer of bone marrow-derived stem cells relative to the time of injury and the optimal cell type [whole bone marrow, mobilized peripheral blood, HSC, facilitating cells (FC)] were determined by counting the number of GFP(+) cells in whole eye flat mounts. Immunocytochemistry was performed to identify the bone marrow origin of the cells in the RPE using antibodies for CD45, Sca-1, and c-kit, as well as the expression of the RPE-specific marker, RPE-65. The time at which bone marrow-derived cells were adoptively transferred relative to the time of NaIO(3) injection did not significantly influence the number of cells that homed to the subretinal space. At both one and two weeks after intravenous (i.v.) injection, GFP(+) cells of bone marrow origin were observed in the damaged subretinal space, at sites of RPE loss, but not in the normal subretinal space. The combined transplantation of HSC+FC cells appeared to favor the survival of the homed stem cells at two weeks, and RPE-65 was expressed by adoptively transferred HSC by four weeks. We have shown that systemically injected HSC homed to the subretinal space in the presence of RPE damage and that FC promoted survival of these cells. Furthermore, the RPE-specific marker RPE-65 was expressed on adoptively transferred HSC in the denuded areas. PMID:16949576

  14. Improved efficiency of the walnut somatic embryo gene transfer system.

    PubMed

    McGranahan, G H; Leslie, C A; Uratsu, S L; Dandekar, A M

    1990-01-01

    AnAgrobacterium-mediated gene transfer system which relies on repetitive embryogenesis to regenerate transgenic walnut plants has been made more efficient by using a more virulent strain ofAgrobacterium and vectors containing genes for both kanamycin resistance and beta-glucuronidase (GUS) activity to facilitate early screening and selection. Two plasmids (pCGN7001 and pCGN7314) introduced individually into the disarmedAgrobacterium host strain EHA101 were used as inoculum. Embryos maintained on medium containing 100 mg/l kanamycin after co-cultivation produced more transformed secondary embryos than embryos maintained on kanamycin-free medium. Of the 186 GUS-positive secondary embryo lines identified, 70% were regenerated from 3 out of 16 primary embryos inoculated with EHA101/pCGN7314 and grown on kanamycin- containing medium, 28% from 4 out of 17 primary embryos inoculated with EHA101/ pCGN7001 and grown on kanamycin medium, and 2% from one out of 13 primary embryos inoculated with EHA101/pCGN7001 but not exposed to kanamycin. Because kanamycin inhibits but does not completely block new embryo formation in controls, identification of transformants formerly required repetitive selection on kanamycin for several months. Introduction of the GUS marker gene allowed positive identification of transformant secondary embryos as early as 5-6 weeks after inoculation. DNA analysis of a representative subset of lines (n=13) derived from secondary embryos confirmed transformation and provided evidence for multiple insertion events in single inoculated primary embryos. PMID:24226275

  15. Orbital transfer vehicle concept definition and system analysis study, 1985. Volume 3: System and program trades

    NASA Technical Reports Server (NTRS)

    Nelson, James H.; Mohrman, Gordon W.; Callan, Daniel R.

    1986-01-01

    The key system and program trade studies performed to arrive at a preferred Orbital Transfer Vehicle (OTV) system concept and evolutionary approach to the acquisition of the requisite capabilites is documented. These efforts were expanded to encompass a Space Transportation Architecture Study (STAS) mission model and recommended unmanned cargo vehicle. The most important factors affecting the results presented are the mission model requirements and selection criteria. The reason for conducting the OTV concept definition and system analyses study is to select a concept and acquisition approach that meets a delivery requirement reflected by the mission model.

  16. New Members' Resource Book: A Reference for Institutions New to the BC Transfer System

    ERIC Educational Resources Information Center

    Finlay, Finola

    2011-01-01

    This resource book is a reference for new member institutions which are those private institutions admitted to the BC Transfer System by way of having one or more programs reviewed by the Degree Quality Assessment Board and given Minister's Consent. All current BC Transfer System members and prospective members (private institutions contemplating…

  17. Construct Validation of an Arabic Version of the Learning Transfer System Inventory for Use in Jordan

    ERIC Educational Resources Information Center

    Khasawneh, Samer; Bates, Reid; Holton, Elwood F., III

    2006-01-01

    The purpose of this study was to translate and validate an Arabic version of the Learning Transfer System Inventory (LTSI) for use in Jordan. The study also investigated the perceptions of transfer system characteristics across selected individual and situational variables. The LTSI was administered to 450 employees of 28 different public and…

  18. Changes to the Transfer Line Collimation System for the High-Luminosity LHC Beams

    SciTech Connect

    Kain, V.; Aberle, O.; Bracco, C.; Fraser, M.; Galleazzi, F.; Gianfelice-Wendt, E.; Kosmicki, A.; Maciariello, F.; Meddahi, M.; Nuiry, F. X.; Steele, G.; Velotti, F.

    2015-06-01

    The current LHC transfer line collimation system will not be able to provide enough protection for the high brightness beams in the high-luminosity LHC era. The new collimation system will have to attenuate more and be more robust than its predecessor. The active jaw length of the new transfer line collimators will therefore be 2.1 m instead of currently 1.2 m. The transfer line optics will have to be adjusted for the new collimator locations and larger beta functions at the collimators for absorber robustness reasons. In this paper the new design of the transfer line collimation system will be presented with its implications on transfer line optics and powering, maintainability, protection of transfer line magnets in case of beam loss on a collimator and protection of the LHC aperture.

  19. Estimating Heat and Mass Transfer Processes in Green Roof Systems: Current Modeling Capabilities and Limitations (Presentation)

    SciTech Connect

    Tabares Velasco, P. C.

    2011-04-01

    This presentation discusses estimating heat and mass transfer processes in green roof systems: current modeling capabilities and limitations. Green roofs are 'specialized roofing systems that support vegetation growth on rooftops.'

  20. Enhanced two phase flow in heat transfer systems

    DOEpatents

    Tegrotenhuis, Ward E; Humble, Paul H; Lavender, Curt A; Caldwell, Dustin D

    2013-12-03

    A family of structures and designs for use in devices such as heat exchangers so as to allow for enhanced performance in heat exchangers smaller and lighter weight than other existing devices. These structures provide flow paths for liquid and vapor and are generally open. In some embodiments of the invention, these structures can also provide secondary heat transfer as well. In an evaporate heat exchanger, the inclusion of these structures and devices enhance the heat transfer coefficient of the evaporation phase change process with comparable or lower pressure drop.

  1. Primary propulsion of electrothermal, ion, and chemical systems for space-based radar orbit transfer

    NASA Technical Reports Server (NTRS)

    Wang, S.-Y.; Staiger, P. J.

    1985-01-01

    An orbit transfer mission concept has been studied for a Space-Based Radar (SBR) where 40 kW required for radar operation is assumed available for orbit transfer propulsion. Arcjet, pulsed electrothermal (PET), ion, and storable chemical systems are considered for the primary propulsion. Transferring two SBR per shuttle flight to 1112 km/60 deg using eiectrical propulsion systems offers an increased payload at the expense of increased trip time, up to 2000 kg each, which may be critical for survivability. Trade offs between payload mass, transfer time, launch site, inclination, and height of parking orbits are presented.

  2. Primary propulsion of electrothermal, ion and chemical systems for space-based radar orbit transfer

    NASA Technical Reports Server (NTRS)

    Wang, S. Y.; Staiger, P. J.

    1985-01-01

    An orbit transfer mission concept has been studied for a Space-Based Radar (SBR) where 40 kW required for radar operation is assumed available for orbit transfer propulsion. Arcjet, pulsed electrothermal (PET), ion, and storable chemical systems are considered for the primary propulsion. Transferring two SBR per shuttle flight to 1112 km/60 deg using electrical propulsion systems offers an increased payload at the expense of increased trip time, up to 2000 kg each, which may be critical for survivability. Trade offs between payload mass, transfer time, launch site, inclination, and height of parking orbits are presented.

  3. Whole-body imaging of adoptively transferred T cells using magnetic resonance imaging, single photon emission computed tomography and positron emission tomography techniques, with a focus on regulatory T cells

    PubMed Central

    Leech, J M; Sharif-Paghaleh, E; Maher, J; Livieratos, L; Lechler, R I; Mullen, G E; Lombardi, G; Smyth, L A

    2013-01-01

    Cell-based therapies using natural or genetically modified regulatory T cells (Tregs) have shown significant promise as immune-based therapies. One of the main difficulties facing the further advancement of these therapies is that the fate and localization of adoptively transferred Tregs is largely unknown. The ability to dissect the migratory pathway of these cells in a non-invasive manner is of vital importance for the further development of in-vivo cell-based immunotherapies, as this technology allows the fate of the therapeutically administered cell to be imaged in real time. In this review we will provide an overview of the current clinical imaging techniques used to track T cells and Tregs in vivo, including magnetic resonance imaging (MRI) and positron emission tomography (PET)/single photon emission computed tomography (SPECT). In addition, we will discuss how the finding of these studies can be used, in the context of transplantation, to define the most appropriate Treg subset required for cellular therapy. PMID:23574314

  4. CORRELATING ELECTRONIC AND VIBRATIONAL MOTIONS IN CHARGE TRANSFER SYSTEMS

    SciTech Connect

    Khalil, Munira

    2014-06-27

    The goal of this research program was to measure coupled electronic and nuclear motions during photoinduced charge transfer processes in transition metal complexes by developing and using novel femtosecond spectroscopies. The scientific highlights and the resulting scientific publications from the DOE supported work are outlined in the technical report.

  5. Segment Transfer: A Consequence of a Dynamic System.

    ERIC Educational Resources Information Center

    Hancin-Bhatt, Barbara

    1994-01-01

    Discusses theoretical explanations of segment transfer in early second-language learning, focusing on the issue of differential substitution. The Feature Competition Model is based on an algorithm for the calculation of feature prominences in the first language based on the principles of underspecification. (62 references) (MDM)

  6. Intramolecular electronic energy transfer in bichromophoric molecular macrocyclic systems

    NASA Astrophysics Data System (ADS)

    Speiser, Shammai

    1993-01-01

    The structures and spectral properties of several bichromophoric molecules, suitable for optical data processing, are presented. The bichromophoric molecules are composed of an aromatic ring connected by two methylene chains to an (alpha) -diketone moiety. Both the absorption and emission spectra of these compounds can be attributed to a superposition of the individual spectra of the separate chromophores. The critical transfer radia for electronic energy transfer from the aromatic (donor) chromophore to the (alpha) -diketone (acceptor) chromophore was calculated from the spectral overlap between the fluorescence spectrum of the aromatic ring with the absorption spectrum of the (alpha) -diketone chromophore. The results show that this series of molecules is well suited for a mechanistic study of short-range intramolecular electronic energy transfer (intra-EET). The temperature and the molecular structure dependence of the intra-EET efficiency in this series was measured and analyzed for both singlet-singlet and triplet-triplet routes. The results show that the transfer efficiency is strongly temperature and structure dependent, indicating that exchange interaction is responsible for intra-EET between close chromophores in a bichromophoric molecule. The relative contributions of interchromophoric distance and that of the relative orientation of the two chromophores to exchange interaction are discussed.

  7. Promising Practices in Statewide Articulation and Transfer Systems

    ERIC Educational Resources Information Center

    Hezel Associates (NJ1), 2010

    2010-01-01

    This guide is based on a study funded by Lumina Foundation for Education and conducted by Hezel Associates and the Western Interstate Commission for Higher Education (WICHE). Designed to aid policymakers and others, this report takes a state-by-state look at practices related to transfer and articulation between two- and four-year public…

  8. Questions about Adoption

    MedlinePlus

    ... Español Text Size Email Print Share Questions About Adoption Page Content Article Body What's the best way to handle my child's questions about her adoption? Many parents want to know when is the ...

  9. What's Happening in Adoption?

    ERIC Educational Resources Information Center

    Gallagher, Ursula M.

    1975-01-01

    Reviews current issues in adoption: termination of parental rights, rights of unwed fathers, subsidized adoption, the recent influx of Vietnamese children, black market babies, agency accountability in placing children, the right of the adoptee to know his biological parents. (ED)

  10. Heat transfer coefficients in two-dimensional Yukawa systems (numerical simulations)

    NASA Astrophysics Data System (ADS)

    Khrustalyov, Yu. V.; Vaulina, O. S.

    2013-05-01

    New data on heat transfer in two-dimensional Yukawa systems have been obtained. The results of a numerical study of the thermal conductivity for equilibrium systems with parameters close to the conditions of laboratory experiments in dusty plasma are presented. The Green-Kubo relations are used to calculate the heat transfer coefficients. The influence of dissipation (internal friction) on the heat transfer processes in nonideal systems is studied. New approximations are proposed for the thermal conductivity and diffusivity for nonideal dissipative systems. The results obtained are compared with the existing experimental and numerical data.

  11. Close binary systems before and after mass transfer. III - Spectroscopic binaries

    NASA Astrophysics Data System (ADS)

    Vansina, F.; De Greve, J. P.

    1982-10-01

    A method is presented, for the computation of absolute dimensions from spectroscopic data on binary systems, which has been adapted for use with the 7th Catalogue of Batten et al. (1978) and takes into account several results of close binary evolution, with emphasis on the phase of slow mass transfer during a case B mass transfer. Among the unevolved systems, the mass transfer case B is found to be the most abundant type of interaction. In the set of evolving systems, a subset of 18 interacting systems was found with mass ratio near unity, the first star being the mass loser as well as the brightest.

  12. Single Parent Adoptive Homes.

    ERIC Educational Resources Information Center

    Shireman, Joan F.

    1996-01-01

    Reviews research and reports on a longitudinal study of 15 single-parent adoptive homes over a 14-year period that demonstrated that these homes have the capacity to be successful adoptive placements. Identifies unique characteristics of single-parent adoptive homes, and notes the need for additional research to identify children for whom these…

  13. Adoption and Identity.

    ERIC Educational Resources Information Center

    Lieberman, E. James

    1998-01-01

    Discusses how adoption responds to ancient questions about origins. Maintains that one's identity hinges on actual relationships more than on pedigree and genes. Discusses reasons for informing a child about his or her adoption. Suggests that adoption is a constructive process involving too many worrisome warnings and anxiety-raising advice by the…

  14. Adoption Factors of the Electronic Health Record: A Systematic Review

    PubMed Central

    2016-01-01

    Background The Health Information Technology for Economic and Clinical Health (HITECH) was a significant piece of legislation in America that served as a catalyst for the adoption of health information technology. Following implementation of the HITECH Act, Health Information Technology (HIT) experienced broad adoption of Electronic Health Records (EHR), despite skepticism exhibited by many providers for the transition to an electronic system. A thorough review of EHR adoption facilitator and barriers provides ongoing support for the continuation of EHR implementation across various health care structures, possibly leading to a reduction in associated economic expenditures. Objective The purpose of this review is to compile a current and comprehensive list of facilitators and barriers to the adoption of the EHR in the United States. Methods Authors searched Cumulative Index of Nursing and Allied Health Literature (CINAHL) and MEDLINE, 01/01/2012–09/01/2015, core clinical/academic journals, MEDLINE full text, and evaluated only articles germane to our research objective. Team members selected a final list of articles through consensus meetings (n=31). Multiple research team members thoroughly read each article to confirm applicability and study conclusions, thereby increasing validity. Results Group members identified common facilitators and barriers associated with the EHR adoption process. In total, 25 adoption facilitators were identified in the literature occurring 109 times; the majority of which were efficiency, hospital size, quality, access to data, perceived value, and ability to transfer information. A total of 23 barriers to adoption were identified in the literature, appearing 95 times; the majority of which were cost, time consuming, perception of uselessness, transition of data, facility location, and implementation issues. Conclusions The 25 facilitators and 23 barriers to the adoption of the EHR continue to reveal a preoccupation on cost, despite

  15. Reaction dynamics and proton coupled electron transfer: studies of tyrosine-based charge transfer in natural and biomimetic systems.

    PubMed

    Barry, Bridgette A

    2015-01-01

    In bioenergetic reactions, electrons are transferred long distances via a hopping mechanism. In photosynthesis and DNA synthesis, the aromatic amino acid residue, tyrosine, functions as an intermediate that is transiently oxidized and reduced during long distance electron transfer. At physiological pH values, oxidation of tyrosine is associated with a deprotonation of the phenolic oxygen, giving rise to a proton coupled electron transfer (PCET) reaction. Tyrosine-based PCET reactions are important in photosystem II, which carries out the light-induced oxidation of water, and in ribonucleotide reductase, which reduces ribonucleotides to form deoxynucleotides. Photosystem II contains two redox-active tyrosines, YD (Y160 in the D2 polypeptide) and YZ (Y161 in the D1 polypeptide). YD forms a light-induced stable radical, while YZ functions as an essential charge relay, oxidizing the catalytic Mn₄CaO₅ cluster on each of four photo-oxidation reactions. In Escherichia coli class 1a RNR, the β2 subunit contains the radical initiator, Y122O•, which is reversibly reduced and oxidized in long range electron transfer with the α2 subunit. In the isolated E. coli β2 subunit, Y122O• is a stable radical, but Y122O• is activated for rapid PCET in an α2β2 substrate/effector complex. Recent results concerning the structure and function of YD, YZ, and Y122 are reviewed here. Comparison is made to recent results derived from bioengineered proteins and biomimetic compounds, in which tyrosine-based charge transfer mechanisms have been investigated. This article is part of a Special Issue entitled: Vibrational spectroscopies and bioenergetic systems. PMID:25260243

  16. Transferability of coarse-grained force field for nCB liquid crystal systems.

    PubMed

    Zhang, Jianguo; Guo, Hongxia

    2014-05-01

    In this paper, the transferability of the coarse-grained (CG) force field originally developed for the liquid crystal (LC) molecule 5CB ( Zhang et al. J. Phys. Chem. B 2012 , 116 , 2075 - 2089 ) was investigated by its homologues 6CB and 8CB molecules. Note that, to construct the 5CB CG force field, we combined the structure-based and thermodynamic quantities-based methods and at the same time attempted to use several fragment molecular systems to derive the CG nonbonded interaction parameters. The resultant 5CB CG force field exhibits a good transferability to some extent. For example, not only the experimental densities, the local packing of atom groups, and the antiparallel arrangements of nearest neighboring molecules, but also the unique LC mesophases as well as the nematic-isotropic phase transition temperatures of 6CB and 8CB were reproduced. Meanwhile, the limitations of this 5CB CG force field were also observed, such as the phase transition from nematic to smectic was postponed to the lower temperature and the resulting smectic phase structure is single-layer-like instead of partially interdigitated bilayer-like as observed in underlying atomistic model. Apparently, more attention should be paid when applying a CG force field to the state point which is quite different from which the force field is explicitly parametrized for. The origin of the above limitations can be potentially traced back to the inherent simplifications and some approximations often adopted in the creation process of CG force field, for example, choosing symmetric CG potentials which do not explicitly include electrostatic interactions and are parametrized by reproducing the target properties of the specific nematic 5CB phase at 300 K and 1 atm, as well as using soft nonbonded potential and excluding torsion barriers. Moreover, although by construction this CG force field could inevitably incorporate both thermodynamic and local structural information on the nematic 5CB phase, the

  17. Transferability of predictive fish distribution models in two coastal systems

    NASA Astrophysics Data System (ADS)

    Sundblad, Göran; Härmä, Meri; Lappalainen, Antti; Urho, Lauri; Bergström, Ulf

    2009-06-01

    Species distribution modelling has emerged as a tool both for exploring niche theory and for producing distribution maps for management. To understand and predict potential effects of large scale habitat change there is a need for proper model validation and applicability also in unstudied areas. However, knowledge about factors influencing the transferability of distribution models, i.e. the accuracy of the models when applying them in a new geographical area, is limited. We have successfully modelled the larval distribution of two fish species, northern pike ( Esox lucius L.) and roach ( Rutilus rutilus L.), on a regional scale in the Baltic Sea using a few and easily measured environmental variables. When models were transferred from the training area to the testing area the models showed reasonable to very good discrimination (ROC 0.75 and 0.93) based on external validation using independent data separated also in time (1-2 years). The predicted larval distribution also overlapped with the distribution of young-of-the-year fish later in the season. Performance when reversing the transfer, by constructing the models in the testing area and predicting back to the original training area, was less successful. This discrepancy was species-specific and could be explained by differences in the species presence ranges along the predictor variables in the testing area compared to the training area. Our results illustrate how transferability success can be influenced by area-specific differences in the range of the predictor variables and show the necessity of validating model predictions properly.

  18. Adopting Internet Standards for Orbital Use

    NASA Technical Reports Server (NTRS)

    Wood, Lloyd; Ivancic, William; da Silva Curiel, Alex; Jackson, Chris; Stewart, Dave; Shell, Dave; Hodgson, Dave

    2005-01-01

    After a year of testing and demonstrating a Cisco mobile access router intended for terrestrial use onboard the low-Earth-orbiting UK-DMC satellite as part of a larger merged ground/space IP-based internetwork, we reflect on and discuss the benefits and drawbacks of integration and standards reuse for small satellite missions. Benefits include ease of operation and the ability to leverage existing systems and infrastructure designed for general use, as well as reuse of existing, known, and well-understood security and operational models. Drawbacks include cases where integration work was needed to bridge the gaps in assumptions between different systems, and where performance considerations outweighed the benefits of reuse of pre-existing file transfer protocols. We find similarities with the terrestrial IP networks whose technologies we have adopted and also some significant differences in operational models and assumptions that must be considered.

  19. Energy transfer processes in semiconductor quantum dots: bacteriorhodopsin hybrid system

    NASA Astrophysics Data System (ADS)

    Rakovich, Aliaksandra; Sukhanova, Alyona; Bouchonville, Nicolas; Molinari, Michael; Troyon, Michel; Cohen, Jacques H. M.; Rakovich, Yury; Donegan, John F.; Nabiev, Igor

    2009-05-01

    The potential impact of nanoscience on energy transfer processes in biomolecules was investigated on the example of a complex between fluorescent semiconductor nanocrystals and photochromic membrane protein. The interactions between colloidal CdTe quantum dots (QDs) and bacteriorhodopsin (bR) protein were studied by a variety of spectroscopic techniques, including integrated and time-resolved fluorescence spectroscopies, zeta potential and size measurement, and fluorescence correlation spectroscopy. QDs' luminescence was found to be strongly modulated by bacteriorhodopsin, but in a controllable way. Decreasing emission lifetimes and blue shifts in QDs' emission at increasing protein concentrations suggest that quenching occurs via Förster resonance energy transfer. On the other hand, concave Stern-Volmer plots and sigmoidal photoluminescence quenching curves imply that the self-assembling of NCs and bR exists, and the number of nanocrystals (NCs) per bacteriorhodopsin contributing to energy transfer can be determined from the inflection points of sigmoidal curves. This number was found to be highly dependent not only on the spectral overlap between NC emission and bR absorption bands, but also on nanocrystal surface charge. These results demonstrate the potential of how inorganic nanoscale materials can be employed to improve the generic molecular functions of biomolecules. The observed interactions between CdTe nanocrystals and bacteriorhodopsin can provide the basis for the development of novel functional materials with unique photonic properties and applications in areas such as all-optical switching, photovoltaics and data storage.

  20. The Transracial Adoption Paradox

    PubMed Central

    Lee, Richard M.

    2008-01-01

    The number of transracial adoptions in the United States, particularly international adoptions, is increasing annually. Counseling psychology as a profession, however, is a relatively silent voice in the research on and practice of transracial adoption. This article presents an overview of the history and research on transracial adoption to inform counseling psychologists of the set of racial and ethnic challenges and opportunities that transracial adoptive families face in everyday living. Particular attention is given to emergent theory and research on the cultural socialization process within these families. PMID:18458794

  1. Migrant Student Record Transfer System: What Is It and Who Uses It? ERIC Digest.

    ERIC Educational Resources Information Center

    Lunon, Janis K.

    Founded in 1969, the Migrant Student Record Transfer System (MSRTS) is a nationwide computerized information network which records, maintains, and rapidly transfers educational and health information on more than 750,000 identified migrant children in 29 states, the District of Columbia, and Puerto Rico. Based in Little Rock, Arkansas, the…

  2. 33 CFR 150.405 - How must a cargo transfer system be tested and inspected?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... be tested and inspected? 150.405 Section 150.405 Navigation and Navigable Waters COAST GUARD... Operations § 150.405 How must a cargo transfer system be tested and inspected? (a) No person may transfer oil... and tested according to this section. (b) The single point mooring (SPM)-CTS must be maintained...

  3. Space transfer concepts and analyses for exploration missions. Technical directive 12: Beamed power systems study

    NASA Technical Reports Server (NTRS)

    Eder, D.

    1992-01-01

    Parametric models were constructed for Earth-based laser powered electric orbit transfer from low Earth orbit to geosynchronous orbit. These models were used to carry out performance, cost/benefit, and sensitivity analyses of laser-powered transfer systems including end-to-end life cycle cost analyses for complete systems. Comparisons with conventional orbit transfer systems were made indicating large potential cost savings for laser-powered transfer. Approximate optimization was done to determine best parameter values for the systems. Orbit transfer flights simulations were conducted to explore effects of parameters not practical to model with a spreadsheet. The simulations considered view factors that determine when power can be transferred from ground stations to an orbit transfer vehicle and conducted sensitivity analyses for numbers of ground stations, Isp including dual-Isp transfers, and plane change profiles. Optimal steering laws were used for simultaneous altitude and plane change. Viewing geometry and low-thrust orbit raising were simultaneously simulated. A very preliminary investigation of relay mirrors was made.

  4. Identification of boiler inlet transfer functions and estimation of system parameters

    NASA Technical Reports Server (NTRS)

    Miles, J. H.

    1972-01-01

    An iterative computer method is described for identifying boiler transfer functions using frequency response data. An objective penalized performance measure and a nonlinear minimization technique are used to cause the locus of points generated by a transfer function to resemble the locus of points obtained from frequency response measurements. Different transfer functions can be tried until a satisfactory empirical transfer function of the system is found. To illustrate the method, some examples and some results from a study of a set of data consisting of measurements of the inlet impedance of a single tube forced flow boiler with inserts are given.

  5. Drivers Impacting the Adoption of Sustainable Agricultural Management Practices and Production Systems of the Northeast and Southeast U.S

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Agricultural production responds to economic, social, environmental, and technological drivers operating both internal and external to the production system. These drivers influence producers’ decision making processes, and act to shape the individual production systems through modification of produ...

  6. Code System to Predict LWR Reflood Heat Transfer.

    1999-04-27

    Version: 00 REFLUX calculates the temperature-time history of a representative fuel rod during the reflood stage of a hypothetical loss-of-coolant accident (LOCA). The logic used fo selection of the appropriate flow regime for analysis of the cladding temperature transient is based on the axial position with regard to the continuous liquid level (based on a mass balance), a liquid carry-over criterion (derived from a force balance on a drop suspended in a vapor stream), andmore » the local cladding surface temperature. A generalized boiling curve is constructed, and the local flow and clad conditions determine the applicable heat transfer coefficient.« less

  7. Transfer matrix approach to layered systems with axial symmetry

    NASA Technical Reports Server (NTRS)

    Bahar, L. Y.

    1976-01-01

    The stress and displacement distribution in a layered medium is found by means of transfer matrices. The surface loading exhibits axial symmetry, and each layer is of infinite extent in the horizontal direction, of constant depth, and is considered to be linearly elastic, homogeneous, and isotropic. The method developed has the built-in advantage of enforcing interface continuity conditions automatically. Its application to layered composites shows the flexibility with which it predicts the local as well as the global response of the medium.

  8. Companion animal adoption study.

    PubMed

    Neidhart, Laura; Boyd, Renee

    2002-01-01

    To better understand the outcomes of companion animal adoptions, Bardsley & Neidhart Inc. conducted a series of 3 surveys over a 1-year period with dog and cat owners who had adopted their pet through either a (a) Luv-A-Pet location, (b) Adopt-a-thon, or (c) traditional shelter. This article suggests opportunities to improve owners' perceptions of their pets and the adoption process through (a) providing more information before adoption about pet health and behaviors, (b) providing counseling to potential adopters to place pets appropriately, and (c) educating adopters to promote companion animal health and retention. Results demonstrate that the pet's relationship to the family unit, such as where the pet sleeps and how much time is spent with the pet, is related to the amount of veterinary care the companion animal receives, and to long-term retention. Satisfaction and retention are attributed to the pet's personality, compatibility, and behavior, rather than demographic differences among adopters or between adoption settings. The age of the companion animal at adoption, the intended recipient, and presence of children in the home also play a role. Health problems were an issue initially for half of all adopted pets, but most were resolved within 12 months. Roughly one fourth of adopters who no longer have their companion animal said their pet died. Characteristics of pets that died support the contention that spaying and neutering profoundly affects a companion animal's life span. Although retention is similar for dogs and cats, mortality is higher among cats in the first year after adoption. PMID:12578739

  9. “When You’re Sitting on the Fence, Hope’s the Hardest Part”: Challenges and Experiences of Heterosexual and Same-Sex Couples Adopting Through the Child Welfare System

    PubMed Central

    Moyer, April M.; Kinkler, Lori A.; Richardson, Hannah B.

    2012-01-01

    Foster-to-adopt families can be viewed as systems that are influenced by many other systems (e.g., the legal system, the social service agency, and the birth family). The current qualitative study of 84 foster-to-adopt parents (members of 42 lesbian, gay, and heterosexual couples) examined the types of challenges that parents faced as they navigated multiple systems during the initial post-placement period. Some participants described the legal insecurity associated with their role as foster-to-adopt parents as impacting their personal well-being and their attachment to their children. Lack of support services and disorganization within social service agencies, as well as strained relationships with birth parents, were also identified as stressors for foster-to-adopt parents. Importantly, lesbian and gay participants faced additional concerns regarding the security of their placement, due to the possibility for discrimination within the various systems involved with the foster-to-adopt process. Participants as a whole also identified positive aspects of their experiences within various systems; for example, they appreciated child care subsidies, state-provided health insurance, and supportive social workers. Our findings provide insights into foster-to-adopt parents’ experiences during the initial post-placement period, and have implications for adoption services aimed to improve placement stability and enhance family functioning in foster-to-adopt families. PMID:23226935

  10. How fast is optically induced electron transfer in organic mixed valence systems?

    PubMed

    Lambert, C; Moos, M; Schmiedel, A; Holzapfel, M; Schäfer, J; Kess, M; Engel, V

    2016-07-28

    The rate of thermally induced electron transfer in organic mixed valence compounds has thoroughly been investigated by e.g. temperature dependent ESR spectroscopy. However, almost nothing is known about the dynamics of optically induced electron transfer processes in such systems. Therefore, we investigated these processes in mixed valence compounds based on triphenylamine redox centres bridged by conjugated spacers by NIR transient absorption spectroscopy with fs-time resolution. These experiments revealed an internal conversion (IC) process to be on the order of 50-200 fs which is equivalent to the back electron transfer after optical excitation into the intervalence charge transfer band. This IC is followed by ultrafast cooling to the ground state within 1 ps. Thus, in the systems investigated optically induced electron transfer is about 3-4 orders of magnitude faster than thermally induced ET. PMID:27376572

  11. Bridge-mediated hopping or superexchange electron-transfer processes in bis(triarylamine) systems

    NASA Astrophysics Data System (ADS)

    Lambert, Christoph; Nöll, Gilbert; Schelter, Jürgen

    2002-09-01

    Hopping and superexchange are generally considered to be alternative electron-transfer mechanisms in molecular systems. In this work we used mixed-valence radical cations as model systems for the investigation of electron-transfer pathways. We show that substituents attached to a conjugated bridge connecting two triarylamine redox centres have a marked influence on the near-infrared absorption spectra of the corresponding cations. Spectral analysis, followed by evaluation of the electron-transfer parameters using the Generalized Mulliken-Hush theory and simulation of the potential energy surfaces, indicate that hopping and superexchange are not alternatives, but are both present in the radical cation with a dimethoxybenzene bridge. We found that the type of electron-transfer mechanism depends on the bridge-reorganization energy as well as on the bridge-state energy. Because superexchange and hopping follow different distance laws, our findings have implications for the design of new molecular and polymeric electron-transfer materials.

  12. The fuzzy control policy implementation of software and hardware adopted in automatically changing receiver system of 25m radio telescope

    NASA Astrophysics Data System (ADS)

    Wang, Xiang-Feng; Zhang, Jin; Aili, Yu

    2005-09-01

    It is difficult to control a system based only on its precise mathematic model by classical control policy in the condition that their precise mathematic models can not be found and their parameters are variable in outer environment. With the rapid development in software and hardware, a system using the fuzzy control policy can get very good effects in some conditions. According to the system environment, fuzzy control policy is selected to implement automatically changing receivers in the base of PC hardwares and Windows2000/XP operation system.

  13. ASME Heat Transfer Division: Proceedings. Volume 1: Heat transfer in microgravity systems, radiative heat transfer and radiative heat transfer in low-temperature environments, and thermal contact conductance and inverse problems in heat transfer; HTD-Volume 332

    SciTech Connect

    Gopinath, A.; Sadhal, S.S.; Jones, P.D.; Seyed-Yagoobi, J.; Woodbury, K.A.

    1996-12-31

    In the first section on heat transfer in microgravity, the papers cover phase-change phenomena and thermocapillary flows and surface effects. In the second section, several papers cover solution methods for radiative heat transfer while the rest cover heat transfer in low-temperature environments. The last section covers papers containing valuable information for thermal contact conductance of various materials plus papers on inverse problems in heat transfer. Separate abstracts were prepared for most papers in this volume.

  14. Development of bagless transfer system for standard waste boxes

    SciTech Connect

    Presgrove, S.B.; Patel, K.

    1991-12-31

    At several DOE site, substantial volumes of Transuranic (TRU) waste has been handled on a daily basis. Usually, the waste has been transferred from the facilities to the Waste Isolation Pilot Plant (WIPP) or to an on site storage facility using the ``bag-out`` technique. This process begins in the most contaminated area by placing the waste in a strong plastic bag, twisting closed the neck of the bag, then taping the closed neck. This reduces the exposed TRU waste and the resulting contamination. However, even though that the contamination is reduced, it remains high enough to prevent direct transfer into the environment. In order to reduce the contamination to acceptable levels, the ``bag-out`` process is repeated until the outside contamination on the plastic bag is acceptable. This procedure has been affective, however, it also generates organic waste in the process. During the design of the Transuranic Waste Facility (TWF) at the Savannah River Site, a conceptual alternative was developed using the Standard Waste Box (SWB).

  15. Development of bagless transfer system for standard waste boxes

    SciTech Connect

    Presgrove, S.B.; Patel, K. )

    1991-01-01

    At several DOE site, substantial volumes of Transuranic (TRU) waste has been handled on a daily basis. Usually, the waste has been transferred from the facilities to the Waste Isolation Pilot Plant (WIPP) or to an on site storage facility using the bag-out'' technique. This process begins in the most contaminated area by placing the waste in a strong plastic bag, twisting closed the neck of the bag, then taping the closed neck. This reduces the exposed TRU waste and the resulting contamination. However, even though that the contamination is reduced, it remains high enough to prevent direct transfer into the environment. In order to reduce the contamination to acceptable levels, the bag-out'' process is repeated until the outside contamination on the plastic bag is acceptable. This procedure has been affective, however, it also generates organic waste in the process. During the design of the Transuranic Waste Facility (TWF) at the Savannah River Site, a conceptual alternative was developed using the Standard Waste Box (SWB).

  16. A Simple, Visually Oriented Communication System to Improve Postoperative Care Following Microvascular Free Tissue Transfer: Development, Results, and Implications.

    PubMed

    Henderson, Peter W; Landford, Wilmina; Gardenier, Jason; Otterburn, David M; Rohde, Christine H; Spector, Jason A

    2016-07-01

    Background Communication, particularly transmission of information between the surgical and nursing teams, has been identified as one of the most crucial determinants of patient outcomes. Nonetheless, transfer of information among and between the physician and nursing teams in the immediate postoperative period is often informal, verbal, and inconsistent. Methods An iterative process of multidisciplinary information gathering was undertaken to create a novel postoperative communication system (the "Pop-form"). Once developed, nurses were surveyed on multiple measures regarding the perceived likelihood that it would improve their ability to provide directed patient care. Data were quantified using a Likert scale (0-10), and statistically analyzed. Results The Pop-form records and transfers operative details, specific anatomic monitoring parameters, and senior physician contact information. Sixty-eight nurses completed surveys. The perceived usefulness of different components of the Pop-form system was as follows: 8.9 for the description of the procedure; 9.3 for the operative diagram; 9.4 for the monitoring details and parameters; and 9.4 for the direct contact information for the appropriate surgical team member. All respondents were in favor of widespread adoption of the Pop-form. Conclusion This uniform, visual communication system requires less than 1 minute to compose, yet formalizes and standardizes inter-team communication, and therefore shows promise for improving outcomes following microvascular free tissue transfer. We believe that this simple, innovative communication tool has the potential to be more broadly applied to many other health care settings. PMID:26872024

  17. Secular dynamics in hierarchical three-body systems with mass loss and mass transfer

    SciTech Connect

    Michaely, Erez; Perets, Hagai B.

    2014-10-20

    Recent studies have shown that secular evolution of triple systems can play a major role in the evolution and interaction of their inner binaries. Very few studies explored the stellar evolution of triple systems, and in particular the mass-loss phase of the evolving stellar components. Here we study the dynamical secular evolution of hierarchical triple systems undergoing mass loss. We use the secular evolution equations and include the effects of mass loss and mass transfer, as well as general relativistic effects. We present various evolutionary channels taking place in such evolving triples, and discuss both the effects of mass loss and mass transfer in the inner binary system, as well as the effects of mass loss/transfer from an outer third companion. We discuss several distinct types/regimes of triple secular evolution, where the specific behavior of a triple system can sensitively depend on its hierarchy and the relative importance of classical and general relativistic effects. We show that the orbital changes due to mass-loss and/or mass-transfer processes can effectively transfer a triple system from one dynamical regime to another. In particular, mass loss/transfer can both induce and quench high-amplitude (Lidov-Kozai) variations in the eccentricity and inclination of the inner binaries of evolving triples. They can also change the system dynamics from an orderly periodic behavior to a chaotic one, and vice versa.

  18. 33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... in areas of high ambient noise levels where hearing protection is required under § 150.615 of...

  19. 33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... in areas of high ambient noise levels where hearing protection is required under § 150.615 of...

  20. 33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... in areas of high ambient noise levels where hearing protection is required under § 150.615 of...

  1. 33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... in areas of high ambient noise levels where hearing protection is required under § 150.615 of...

  2. 33 CFR 149.130 - What are the requirements for the cargo transfer system alarm?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... EQUIPMENT Pollution Prevention Equipment § 149.130 What are the requirements for the cargo transfer system... in areas of high ambient noise levels where hearing protection is required under § 150.615 of...

  3. The mechanism of thermal-gradient mass transfer in the sodium hydroxide-nickel system

    NASA Technical Reports Server (NTRS)

    May, Charles E

    1958-01-01

    "Thermal-gradient mass transfer" was investigated in the molten sodium hydroxide-nickel system. Possible mechanisms (physical, electrochemical, and chemical) are discussed in terms of experimental and theoretical evidence. Experimental details are included in appendixes.

  4. Purification of melanoma reactive T cell by using a monocyte-based solid phase T-cell selection system for adoptive therapy.

    PubMed

    Li, Jongming; Mookerjee, Bijoyesh; Wagner, John

    2008-01-01

    The generation of melanoma-reactive T cells with the characteristics necessary for in vivo effectiveness remains a considerable obstacle to the application of adoptive cell therapy. Recent clinical success with adoptive cell therapy for melanoma is motivating additional investigation to improve the technology of generating such tumor reactive lymphocytes. Here we describe a novel solid phase T-cell selection system, in which monocytes are immobilized on solid support for antigen-specific T-cell purification. We hypothesized and proved that antigen-specific T cells recognize their cognate antigens and bind to them faster than nonantigen-specific T cells and are concentrated on the surface after removing the nonadherent cells by washing. Moreover, activated antigen-specific T cells proliferated more rapidly than nonspecific T cells, further increasing the frequency and purity of antigen-specific T cells. Optimal selection times for Melan-A-specific T cells are studied. Our data demonstrated that T-cell selection can usually increase the frequency of tumor antigen-specific T cells by >10-fold, whereas T-cell expansion after the selection boost the frequency of tumor antigen-specific T cells by another approximately 10-fold. More importantly, these T cells are generated under more physiologic conditions. This new T-cell selection system is superior to traditional repeated stimulation methods in generating tumor antigen-specific T cells for adoptive cell immunotherapy. This inexpensive and simple T-cell selection system can produce large quantity of highly purified Melan-A-specific T cells within 2 weeks after T-cell activation. PMID:18157015

  5. Chief Information Officer's Role in Adopting an Interoperable Electronic Health Record System for Medical Data Exchange

    ERIC Educational Resources Information Center

    Akpabio, Akpabio Enebong Ema

    2013-01-01

    Despite huge growth in hospital technology systems, there remains a dearth of literature examining health care administrator's perceptions of the efficacy of interoperable EHR systems. A qualitative research methodology was used in this multiple-case study to investigate the application of diffusion of innovations theory and the technology…

  6. Systems to Control Molten Metal Transfer in Arc Welding

    NASA Astrophysics Data System (ADS)

    Filonov, A. V.; Kryukov, A. V.; Gusarov, D. E.

    2015-09-01

    The paper analyzes the systems used for controlling molten wire metal droplets during the arc welding process in shielding gases. The variations for implementing the relevant systems are given, with the positive and negative aspects of such implementation taken into account. Electrical systems are currently investigated to the fullest extent possible and implemented in different power sources for pulsed welding arc. Mechanical systems are represented by different types of feeders that provide the pulsed wire feeding process. The feed mechanisms driven by electric motors and electromagnets are analyzed. In addition to the mechanical and electrical systems, the examples of combined control systems are given.

  7. Simulation of a Wireless Power Transfer System for Electric Vehicles with Power Factor Correction

    SciTech Connect

    Pickelsimer, Michael C; Tolbert, Leon M; Ozpineci, Burak; Miller, John M

    2012-01-01

    Wireless power transfer has been a popular topic of recent research. Most research has been done to address the limitations of coil-to-coil efficiency. However, little has been done to address the problem associated with the low input power factor with which the systems operate. This paper details the steps taken to analyze a wireless power transfer system from the view of the power grid under a variety of loading conditions with and without power factor correction.

  8. Pythagorean coupling: Complete population transfer in a four-state system

    SciTech Connect

    Suchowski, Haim; Silberberg, Yaron; Uskov, Dmitry B.

    2011-07-15

    Complete population transfer in a four-coupled-modes system is analyzed from a geometrical point of view. An analytical solution of the dynamics is written by the use of two distinct frequencies, the generalization of the single Rabi frequency of the two-state dynamics. We also present its visualization on two separate Bloch spheres with two independent torque equations. With this scheme we analytically derive the requirements for complete population transfer in a four-state quantum system. Interestingly, the solutions are found to be linked to fundamental number theory, whereas complete population transfer occurs only if the ratios between coupling coefficients exactly match a set of Pythagorean triples.

  9. Vent System Analysis for the Cryogenic Propellant Storage Transfer Ground Test Article

    NASA Technical Reports Server (NTRS)

    Hedayat, A

    2013-01-01

    To test and validate key capabilities and technologies required for future exploration elements such as large cryogenic propulsion stages and propellant depots, NASA is leading the efforts to develop and design the Cryogenic Propellant Storage and Transfer (CPST) Cryogenic Fluid Management (CFM) payload. The primary objectives of CPST payload are to demonstrate: 1) in-space storage of cryogenic propellants for long duration applications; and 2) in-space transfer of cryogenic propellants. The Ground Test Article (GTA) is a technology development version of the CPST payload. The GTA consists of flight-sized and flight-like storage and transfer tanks, liquid acquisition devices, transfer, and pressurization systems with all of the CPST functionality. The GTA is designed to perform integrated passive and active thermal storage and transfer performance testing with liquid hydrogen (LH2) in a vacuum environment. The GTA storage tank is designed to store liquid hydrogen and the transfer tank is designed to be 5% of the storage tank volume. The LH2 transfer subsystem is designed to transfer propellant from one tank to the other utilizing pressure or a pump. The LH2 vent subsystem is designed to prevent over-pressurization of the storage and transfer tanks. An in-house general-purpose computer program was utilized to model and simulate the vent subsystem operation. The modeling, analysis, and the results will be presented in the final paper.

  10. A technology transfer plan for the US Department of Energy's Electric Energy Systems Program

    SciTech Connect

    Harrer, B.J.; Hurwitch, J.W.; Davis, L.J.

    1986-11-01

    The major objective of this study was to develop a technology transfer plan that would be both practical and effective in promoting the transfer of the products of DOE/EES research to appropriate target audiences. The study drew upon several major components of the marketing process in developing this plan: definition/charcterization of the products being produced by the DOE/EES program, identification/characterization of possible users of the products being produced by the program, and documentation/analysis of the methods currently being used to promote the adoption of DOE/EES products. Fields covered include HVDC, new materials, superconductors, electric field effects, EMP impacts, battery storage/load leveling, automation/processing concepts, normal/emergency operating concepts, Hawaii deep water cable, and failure mechanisms.

  11. The interplay between Epstein-Barr virus and the immune system: a rationale for adoptive cell therapy of EBV-related disorders

    PubMed Central

    Merlo, Anna; Turrini, Riccardo; Dolcetti, Riccardo; Martorelli, Debora; Muraro, Elena; Comoli, Patrizia; Rosato, Antonio

    2010-01-01

    The Epstein-Barr virus has evolved a plethora of strategies to evade immune system recognition and to establish latent infection in memory B cells, where the virus resides lifelong without any consequence in the majority of individuals. However, some imbalances in the equilibrium between the inherent virus transforming properties and the host immune system can lead to the development of different tumors, such as lymphoproliferative disorders, Hodgkin’s lymphoma, Burkitt’s lymphoma, and nasopharyngeal carcinoma. The expression of viral antigens in malignant cells makes them suitable targets for immunotherapeutic approaches, which are mainly based on the ex vivo expansion of EBV-specific T cells. Indeed, the infusion of virus-specific cytotoxic T lymphocytes has proved not only to be safe and effective, but also capable of restoring or inducing a protective anti-virus immunity, which is lacking, albeit to a different extent, in every EBV-driven malignancy. The purpose of this review is to summarize the results of adoptive immunotherapy approaches for EBV-related malignancies, with particular emphasis on the immunological and virological aspects linked to the clinical responses obtained. Data collected confirm the clinical relevance of the use of EBV-specific cytotoxic T lymphocytes in the field of adoptive immunotherapy and suggest the increasing importance of this approach also against other tumors, concurrent with the increasing knowledge of the intimate and continuous interplay between the virus and the host immune system. PMID:20421267

  12. Heat-Transfer Fluids for Solar-Energy Systems

    NASA Technical Reports Server (NTRS)

    Parker, J. C.

    1982-01-01

    43-page report investigates noncorrosive heat-transport fluids compatible with both metallic and nonmetallic solar collectors and plumbing systems. Report includes tables and figures of X-ray inspections for corrosion and schematics of solar-heat transport systems and heat rejection systems.

  13. 78 FR 42875 - Community Right-to-Know; Adoption of 2012 North American Industry Classification System (NAICS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION... Classification System (NAICS) Codes for Toxics Release Inventory (TRI) Reporting AGENCY: Environmental Protection..., Environmental Protection Agency, Mailcode 2822T, 1200 Pennsylvania Ave. NW., Washington, DC, 20460 Hand...

  14. An optical system adopting liquid crystals with electrical tunability of wavelength and energy density for low level light therapy

    NASA Astrophysics Data System (ADS)

    Chang, Chia-Ming; Wang, Yu-Jen; Chen, Hung-Shan; Lin, Yi-Hsin; Srivastava, Abhishek K.; Chigrinov, Vladimir G.

    2015-09-01

    We have developed a bistable negative lens by integrating a polarization switch of ferroelectric liquid crystals (FLCs) with a passively anisotropic focusing element. The proposed lens not only exhibits electrically tunable bistability but also fast response time of sub-milliseconds, which leads to good candidate of optical component in optical system for medical applications. In this paper, we demonstrate an optical system consisting of two FLC phase retarders and one LC lenses that exhibits both of electrically tunable wavelength and size of exposure area. The operating principles and the experimental results are discussed. The tunable spectrum, exposure area size and tunable irradiance are illustrated. Compared to conventional lenses with mechanical movements in the medical light therapy system, our electrically switchable optical system is more practical in the portable applications of light therapy (LLLT).

  15. Dual manifold system and method for fluid transfer

    SciTech Connect

    Doktycz, Mitchel J.; Bryan, William Louis; Kress, Reid

    2003-05-27

    A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

  16. Interfacial Charge Transfer States in Condensed Phase Systems

    NASA Astrophysics Data System (ADS)

    Vandewal, Koen

    2016-05-01

    Intermolecular charge transfer (CT) states at the interface between electron-donating (D) and electron-accepting (A) materials in organic thin films are characterized by absorption and emission bands within the optical gap of the interfacing materials. CT states efficiently generate charge carriers for some D-A combinations, and others show high fluorescence quantum efficiencies. These properties are exploited in organic solar cells, photodetectors, and light-emitting diodes. This review summarizes experimental and theoretical work on the electronic structure and interfacial energy landscape at condensed matter D-A interfaces. Recent findings on photogeneration and recombination of free charge carriers via CT states are discussed, and relations between CT state properties and optoelectronic device parameters are clarified.

  17. Interfacial Charge Transfer States in Condensed Phase Systems.

    PubMed

    Vandewal, Koen

    2016-05-27

    Intermolecular charge transfer (CT) states at the interface between electron-donating (D) and electron-accepting (A) materials in organic thin films are characterized by absorption and emission bands within the optical gap of the interfacing materials. CT states efficiently generate charge carriers for some D-A combinations, and others show high fluorescence quantum efficiencies. These properties are exploited in organic solar cells, photodetectors, and light-emitting diodes. This review summarizes experimental and theoretical work on the electronic structure and interfacial energy landscape at condensed matter D-A interfaces. Recent findings on photogeneration and recombination of free charge carriers via CT states are discussed, and relations between CT state properties and optoelectronic device parameters are clarified. PMID:26980308

  18. Population transfer in a Lambda system induced by detunings

    NASA Astrophysics Data System (ADS)

    Di Stefano, P. G.; Paladino, E.; D'Arrigo, A.; Falci, G.

    2015-06-01

    In this paper we propose a protocol to achieve coherent population transfer between two states in a three-level atom by using two ac fields. It is based on the physics of stimulated Raman adiabatic passage (STIRAP), but it is implemented with the constraint of a reduced control, namely, one of the fields cannot be switched off. A combination of frequency chirps is used with resonant fields, allowing us to achieve approximate destructive interference, despite the fact that an exact dark state does not exist. This chirped STIRAP protocol is tailored for applications to artificial atoms, where architectures with several elementary units can be strongly coupled but where the possibility of switching on and off such couplings is often very limited. Demonstration of this protocol would be a benchmark for the implementation of a class of multilevel advanced control procedures for quantum computation and microwave quantum photonics in artificial atoms.

  19. Dual manifold system and method for fluid transfer

    DOEpatents

    Doktycz, Mitchel J.; Bryan, William Louis; Kress, Reid

    2003-09-30

    A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

  20. Code System to Calculate Heat and Mass Transfer In Concrete

    1999-05-26

    Version 00 This version is designated USINTC and was developed to model the thermal response of concrete to very high heating rates such as might occur from sodium spills on concrete surfaces in a breeder reactor. The major phenomena treated are conductive energy transport; chemical decomposition of concrete; and two-phase, three-component heat and mass transfer of the decomposition products: steam, liquid water, and carbon dioxide. The USINT model provides for porosity to increase as watermore » and carbon-dioxide are formed from the concrete. The concrete is treated generally as divided into two basic regions, wet and dry. In the wet region, steam, carbon-dioxide, and liquid water may co-exist, but in the dry region, there is no liquid water. There is also the possibility of a third region in which there is only liquid water and no gases.« less