Science.gov

Sample records for adults exhibited significantly

  1. Fetal ACL Fibroblasts Exhibit Enhanced Cellular Properties Compared with Adults

    PubMed Central

    Stalling, Simone S.

    2008-01-01

    Fetal tendons and skin heal regeneratively without scar formation. Cells isolated from these fetal tissues exhibit enhanced cellular migration and collagen production in comparison to cells from adult tissue. We determined whether fetal and adult fibroblasts isolated from the anterior cruciate ligament (ACL), a tissue that does not heal regeneratively, exhibit differences in cell migration rates and collagen elaboration. An in vitro migration assay showed fetal ACL fibroblasts migrated twice as fast as adult ACL fibroblasts at a rate of 38.90 ± 7.69 μm per hour compared with 18.88 ± 4.18 μm per hour, respectively. Quantification of Type I collagen elaboration by enzyme-linked immunosorbent assay showed fetal ACL fibroblasts produced four times the amount of Type I collagen compared with adult ACL fibroblasts after 7 days in culture. We observed no differences in Type III collagen with time for adult or fetal ACL fibroblasts. Our findings indicate fetal ACL fibroblasts are intrinsically different from adult ACL fibroblasts, suggesting the healing potential of the ACL may be age-dependent. PMID:18648900

  2. 78 FR 55134 - Culturally Significant Object Imported for Exhibition Determinations: “Iran Modern”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-09

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Iran Modern'' ACTION: Notice..., number 153) of determinations made by the Department of State pertaining to the exhibit ``Iran Modern... in the exhibition ``Iran Modern,'' imported from abroad for temporary exhibition within the...

  3. 76 FR 23642 - Culturally Significant Object Imported for Exhibition Determinations: “Sarcophagus”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Sarcophagus'' SUMMARY: Notice is..., I hereby determine that the object to be included in the exhibition ``Sarcophagus,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object...

  4. 78 FR 4586 - Culturally Significant Object Imported for Exhibition Determinations: “Gutai: Splendid Playground”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Gutai: Splendid Playground'' SUMMARY... object to be included in the exhibition ``Gutai: Splendid Playground,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported...

  5. 75 FR 32980 - Culturally Significant Objects Imported for Exhibition Determinations: “Ringo Starr's Snare Drum”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Ringo Starr's Snare Drum'' SUMMARY... included in the exhibit ``Ringo Starr's Snare Drum,'' imported from abroad for temporary exhibition...

  6. 75 FR 28095 - Culturally Significant Objects Imported for Exhibition Determinations: “Picasso Looks at Degas”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Picasso Looks at Degas'' SUMMARY... included in the exhibition ``Picasso Looks at Degas,'' imported from abroad for temporary exhibition...

  7. 76 FR 53705 - Culturally Significant Objects Imported for Exhibition; Determinations: “Seductive Luxury and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... Culturally Significant Objects Imported for Exhibition; Determinations: ``Seductive Luxury and Innovation... ``Seductive Luxury and Innovation: The Furniture of Abraham and David Roentgen,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported...

  8. 78 FR 33885 - Culturally Significant Object Imported for Exhibition Determinations: “Fauno Rosso”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-05

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Fauno Rosso'' SUMMARY: Notice is... object to be included in the exhibition ``Fauno Rosso,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a...

  9. 76 FR 58075 - Culturally Significant Object Imported for Exhibition Determinations: “Cervera Bible”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Cervera Bible'' SUMMARY: Notice is... object to be included in the exhibition ``Cervera Bible,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a...

  10. 76 FR 81004 - Culturally Significant Object Imported for Exhibition Determinations: “Nordkapp”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Nordkapp'' SUMMARY: Notice is hereby... object to be included in the exhibition ``Nordkapp,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a...

  11. 77 FR 53959 - Culturally Significant Object Imported for Exhibition Determinations: “Pedimental Relief”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Pedimental Relief'' SUMMARY: Notice... object to be included in the exhibition ``Pedimental Relief,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a...

  12. 78 FR 46402 - Culturally Significant Object Imported for Exhibition Determinations: “The Dying Gaul”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... Culturally Significant Object Imported for Exhibition Determinations: ``The Dying Gaul'' SUMMARY: Notice is... object to be included in the exhibition ``The Dying Gaul,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a...

  13. 75 FR 53012 - Culturally Significant Object Imported for Exhibition Determinations: “Ivory Mirror Case”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Ivory Mirror Case'' SUMMARY: Notice..., I hereby determine that the object to be included in the exhibition ``Ivory Mirror Case,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The...

  14. 76 FR 38452 - Culturally Significant Object Imported for Exhibition Determinations: “King Amenemhet II”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ... Culturally Significant Object Imported for Exhibition Determinations: ``King Amenemhet II'' SUMMARY: Notice..., I hereby determine that the object to be included in the exhibition ``King Amenemhet II,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The...

  15. 76 FR 67017 - Culturally Significant Object Imported for Exhibition Determinations: “La Surprise”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-28

    ... Culturally Significant Object Imported for Exhibition Determinations: ``La Surprise'' SUMMARY: Notice is... object to be included in the exhibition ``La Surprise,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a...

  16. 77 FR 56697 - Culturally Significant Object Imported for Exhibition Determinations: “Steve McQueen”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Steve McQueen'' SUMMARY: Notice is... object to be included in the exhibition ``Steve McQueen,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a...

  17. 75 FR 47337 - Culturally Significant Objects Imported for Exhibition Determinations: “German Impressionist...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``German Impressionist Landscape... the exhibition ``German Impressionist Landscape Painting: Liebermann--Corinth--Slevogt,''...

  18. 76 FR 1660 - Culturally Significant Objects Imported for Exhibition Determinations: “Reconfiguring an African...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Reconfiguring an African Icon: Odes... hereby determine that the objects to be included in the exhibition ``Reconfiguring an African Icon:...

  19. 78 FR 55772 - Culturally Significant Object Imported for Exhibition Determinations: “Beauty Revealed: Images of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Beauty Revealed: Images of Women in...: Images of Women in Qing Dynasty Chinese Painting,'' imported from abroad for temporary exhibition...

  20. 75 FR 62916 - Culturally Significant Objects Imported for Exhibition Determinations: “India's Fabled City: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``India's Fabled City: The Art of... ``India's Fabled City: The Art of Courtly Lucknow,'' imported from abroad for temporary exhibition...

  1. 77 FR 48199 - Culturally Significant Objects Imported for Exhibition Determinations: “Bernini: Sculpting in Clay”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Bernini: Sculpting in Clay'' SUMMARY... objects to be included in the exhibition ``Bernini: Sculpting in Clay,'' imported from abroad...

  2. 78 FR 28274 - Culturally Significant Objects Imported for Exhibition Determinations: “Medieval Treasures from...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Medieval Treasures from Hildesheim... determine that the objects to be included in the exhibition ``Medieval Treasures from Hildesheim,''...

  3. 77 FR 6621 - Culturally Significant Objects Imported for Exhibition Determinations: “The Rylands Haggadah...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Rylands Haggadah: Medieval...: Medieval Jewish Art in Context,'' imported from abroad for temporary exhibition within the United...

  4. 75 FR 3272 - Culturally Significant Objects Imported for Exhibition Determinations: “The Sacred Made Real...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Sacred Made Real: Spanish... Real: Spanish Painting and Sculpture 1600-1700,'' imported from abroad for temporary exhibition...

  5. 78 FR 48925 - Culturally Significant Object Imported for Exhibition Determinations: “Violence and Virtue...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Violence and Virtue: Artemisia... April 15, 2003), I hereby determine that the object to be included in the exhibition ``Violence...

  6. 77 FR 22376 - Culturally Significant Objects Imported for Exhibition Determinations: “Ellsworth Kelly: Plant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Ellsworth Kelly: Plant Drawings... Kelly: Plant Drawings,'' imported from abroad for temporary exhibition within the United States, is...

  7. 76 FR 10936 - Culturally Significant Objects Imported for Exhibition Determinations: “Richard Serra Drawing: A...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Richard Serra Drawing: A... ``Richard Serra Drawing: A Retrospective,'' imported from abroad for temporary exhibition within the...

  8. 75 FR 23318 - Culturally Significant Objects Imported for Exhibition Determinations: “John Baldessari: Pure...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``John Baldessari: Pure Beauty... that the objects to be included in the exhibition ``John Baldessari: Pure Beauty,'' imported...

  9. 78 FR 48539 - Culturally Significant Objects Imported for Exhibition Determinations: “Iran Modern”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Iran Modern'' SUMMARY: Notice is... objects to be included in the exhibition ``Iran Modern,'' imported from abroad for temporary...

  10. 78 FR 20372 - Culturally Significant Objects Imported for Exhibition Determinations: “Hall of Ancient Egypt”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Hall of Ancient Egypt'' SUMMARY... objects to be included in the exhibition ``Hall of Ancient Egypt,'' imported from abroad for...

  11. 76 FR 63701 - Culturally Significant Objects Imported for Exhibition Determinations: “Johan Zoffany RA: Society...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Johan Zoffany RA: Society Observed... determine that the objects to be included in the exhibition ``Johan Zoffany RA: Society Observed,''...

  12. 75 FR 25031 - Culturally Significant Objects Imported for Exhibition Determinations: “Tiffany: Color and Light”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Tiffany: Color and Light'' SUMMARY... included in the exhibition ``Tiffany: Color and Light,'' imported from abroad for temporary...

  13. 77 FR 65245 - Culturally Significant Objects Imported for Exhibition Determinations: “Portrait of Spain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Portrait of Spain: Masterpieces From..., 2003), I hereby determine that the objects to be included in the exhibition ``Portrait of...

  14. 77 FR 8943 - Culturally Significant Objects Imported for Exhibition Determinations: “Rembrandt's Self-Portrait”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Rembrandt's Self-Portrait'' SUMMARY... object to be included in the exhibition ``Rembrandt's Self-Portrait,'' imported from abroad for...

  15. 76 FR 53524 - Culturally Significant Objects Imported for Exhibition Determinations: “Once Upon Many Times...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Once Upon Many Times: Legends and... Times: Legends and Myths in Himalayan Art,'' imported from abroad for temporary exhibition within...

  16. 76 FR 44976 - Culturally Significant Objects Imported for Exhibition Determinations: “Heroic Africans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Heroic Africans: Legendary Leaders..., 2003), I hereby determine that the objects to be included in the exhibition ``Heroic...

  17. 77 FR 23318 - Culturally Significant Object Imported for Exhibition Determinations: “African Cosmos: Stellar Arts”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``African Cosmos: Stellar Arts... Cosmos: Stellar Arts,'' imported from abroad for temporary exhibition within the United States, is...

  18. 78 FR 5555 - Culturally Significant Objects Imported for Exhibition Determinations: “SHANGAA, Art of Tanzania”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``SHANGAA, Art of Tanzania'' SUMMARY... objects to be included in the exhibition ``SHANGAA, Art of Tanzania,'' imported from abroad for...

  19. 77 FR 56698 - Culturally Significant Objects Imported for Exhibition Determinations: “Opera Nobile...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Opera Nobile: Masterpieces From..., 2003), I hereby determine that the objects to be included in the exhibition ``Opera...

  20. 76 FR 77299 - Culturally Significant Objects Imported for Exhibition Determinations: “Civic Pride: Group...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Civic Pride: Group Portraits from..., 2003), I hereby determine that the objects to be included in the exhibition ``Civic Pride:...

  1. 78 FR 51802 - Culturally Significant Objects Imported for Exhibition Determinations: “Silla: Korea's Golden...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Silla: Korea's Golden Kingdom... determine that the objects to be included in the exhibition ``Silla: Korea's Golden Kingdom,'' imported...

  2. 78 FR 12134 - Culturally Significant Objects Imported for Exhibition Determinations: “Temple and Tomb...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Temple and Tomb: Prehistoric Malta... determine that the objects to be included in the exhibition ``Temple and Tomb: Prehistoric Malta,''...

  3. 78 FR 79058 - Culturally Significant Objects Imported for Exhibition Determinations: “Chinese Paintings from...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Chinese Paintings from Japanese..., 2003), I hereby determine that the objects to be included in the exhibition ``Chinese Paintings...

  4. 76 FR 4987 - Culturally Significant Objects Imported for Exhibition Determinations: “Bali: Art, Ritual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Bali: Art, Ritual, Performance..., Ritual, Performance,'' imported from abroad for temporary exhibition within the United States, are...

  5. 78 FR 27276 - Culturally Significant Object Imported for Exhibition Determinations: “Goya's Two Hares”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Goya's Two Hares'' SUMMARY: Notice is... object to be included in the exhibition ``Goya's Two Hares,'' imported from abroad for...

  6. 75 FR 82128 - Culturally Significant Objects Imported for Exhibition Determinations: “Vishnu: Hinduism's Blue...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Vishnu: Hinduism's Blue-Skinned... ``Vishnu: Hinduism's Blue-Skinned Savior,'' imported from abroad for temporary exhibition within the...

  7. 75 FR 48736 - Culturally Significant Objects Imported for Exhibition Determinations: “Kurt Schwitters: Color...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Kurt Schwitters: Color and Collage... Schwitters: Color and Collage,'' imported from abroad for temporary exhibition within the United States,...

  8. 75 FR 21384 - Culturally Significant Objects Imported for Exhibition Determinations: “Birth of Impressionism...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Birth of Impressionism: Masterpieces... 15, 2003 , I hereby determine that the objects to be included in the exhibition ``Birth...

  9. 76 FR 5236 - Culturally Significant Objects Imported for Exhibition Determinations: “Upside Down Arctic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Upside Down Arctic Realities... Down Arctic Realities,'' imported from abroad for temporary exhibition within the United States, are...

  10. 75 FR 80885 - Culturally Significant Objects Imported for Exhibition Determinations: “The Buddhist Heritage of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Buddhist Heritage of Pakistan... Buddhist Heritage of Pakistan,'' imported from abroad for temporary exhibition within the United...

  11. 77 FR 61468 - Culturally Significant Objects Imported for Exhibition Determinations: “Balthus: Cats and Girls”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Balthus: Cats and Girls'' SUMMARY... objects to be included in the exhibition ``Balthus: Cats and Girls,'' imported from abroad for...

  12. 75 FR 38589 - Culturally Significant Objects Imported for Exhibition Determinations: “Salvador Dali: The Late...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Salvador Dali: The Late Work... that the objects to be ] included in the exhibition ``Salvador Dali: The Late Work,'' imported...

  13. 75 FR 82127 - Culturally Significant Objects Imported for Exhibition Determinations: “Guitar Heroes: Legendary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Guitar Heroes: Legendary Craftsmen... the exhibition ``Guitar Heroes: Legendary Craftsmen from Italy to New York,'' imported from abroad...

  14. 75 FR 45194 - Culturally Significant Objects Imported for Exhibition Determinations: “Drawing from Nature...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Drawing from Nature: Landscapes by... objects to be included in the exhibition ``Drawing from Nature: Landscapes by Max Liebermann,...

  15. 76 FR 56491 - Culturally Significant Objects Imported for Exhibition Determinations: “Picasso's Drawings, 1890...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Picasso's Drawings, 1890-1921..., 2003), I hereby determine that the objects to be included in the exhibition ``Picasso's Drawings,...

  16. 76 FR 18292 - Culturally Significant Objects Imported for Exhibition Determinations: “The Steins Collect...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Steins Collect: Matisse, Picasso... the exhibition ``The Steins Collect: Matisse, Picasso, and the Parisian Avant-Garde'' imported...

  17. 76 FR 71616 - Culturally Significant Objects Imported for Exhibition Determinations: “The Steins Collect...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Steins Collect: Matisse, Picasso... made by the Department of State pertaining to the exhibition ``The Steins Collect: Matisse,...

  18. 75 FR 78335 - Culturally Significant Objects Imported for Exhibition Determinations: “Thomas Lawrence: Regency...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Thomas Lawrence: Regency Power and... ``Thomas Lawrence: Regency Power and Brilliance,'' imported from abroad for temporary exhibition within...

  19. 78 FR 8682 - Culturally Significant Object Imported for Exhibition Determinations: “Vermeer's Woman in Blue...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Vermeer's Woman in Blue Reading a... ``Vermeer's Woman in Blue Reading a Letter,'' imported from abroad for temporary exhibition within...

  20. 76 FR 4987 - Culturally Significant Objects Imported for Exhibition Determinations: “Treasures From the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Treasures From the Hermitage: Russia... ``Treasures from the Hermitage: Russia's Crown Jewels,'' imported from abroad for temporary exhibition...

  1. 76 FR 2438 - Culturally Significant Objects Imported for Exhibition Determinations: “Kings, Queens, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-13

    ... the exhibition ``Kings, Queens, and Courtiers: Art in Early Renaissance France'' imported from abroad... Culturally Significant Objects Imported for Exhibition Determinations: ``Kings, Queens, and Courtiers: Art in Early Renaissance France'' SUMMARY: Notice is hereby given of the following determinations: Pursuant...

  2. 76 FR 44977 - Culturally Significant Objects Imported for Exhibition Determinations: “De Kooning: A Retrospective”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``De Kooning: A Retrospective... determine that the objects to be included in the exhibition ``De Kooning: A Retrospective,'' imported...

  3. 76 FR 59182 - Culturally Significant Objects Imported for Exhibition Determinations: “Impressionism...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Impressionism: Masterworks on Paper... determine that the objects to be included in the exhibition ``Impressionism: Masterworks on Paper''...

  4. 78 FR 1916 - Culturally Significant Objects Imported for Exhibition; Determinations: “Impressionism, Fashion...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition; Determinations: ``Impressionism, Fashion, and..., 2003), I hereby determine that the objects to be included in the exhibition ``Impressionism,...

  5. 77 FR 25226 - Culturally Significant Objects Imported for Exhibition Determinations: “1812: A Nation Emerges”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``1812: A Nation Emerges'' SUMMARY... objects to be included in the exhibition ``1812: A Nation Emerges,'' imported from abroad for...

  6. 75 FR 51518 - Culturally Significant Objects Imported for Exhibition Determinations: “Ballplayers, Gods, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Ballplayers, Gods, and Rainmaker... objects to be included in the exhibition ``Ballplayers, Gods, and Rainmaker Kings: Masterpieces...

  7. 77 FR 48198 - Culturally Significant Objects Imported for Exhibition Determinations: “Faking It: Manipulated...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Faking It: Manipulated Photography..., 2003), I hereby determine that the objects to be included in the exhibition ``Faking It:...

  8. 76 FR 65558 - Culturally Significant Objects Imported for Exhibition Determinations: “Masterpieces of Landscape...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Masterpieces of Landscape Painting... Landscape Painting from the Forbidden City'' imported from abroad for temporary exhibition within the...

  9. 75 FR 8425 - Culturally Significant Objects Imported for Exhibition Determinations: “Masterpieces of European...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Masterpieces of European Painting... European Painting from Dulwich Picture Gallery,'' imported from abroad for temporary exhibition within...

  10. 77 FR 52783 - Culturally Significant Objects Imported for Exhibition Determinations: “Federico Barocci...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Federico Barocci: Renaissance Master... determine that the objects to be included in the exhibition ``Federico Barocci: Renaissance...

  11. 76 FR 12786 - Culturally Significant Objects Imported for Exhibition Determinations: “Charlotte Salomon: Life...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Charlotte Salomon: Life? Or Theatre... Salomon: Life? Or Theatre?'' imported from abroad for temporary exhibition within the United States,...

  12. 75 FR 82127 - Culturally Significant Objects Imported for Exhibition Determinations: “Gauguin: Maker of Myth”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Gauguin: Maker of Myth'' SUMMARY..., I hereby determine that the objects to be included in the exhibition ``Gauguin: Maker of...

  13. 76 FR 23642 - Culturally Significant Objects Imported for Exhibition Determinations: “Projects 95: Runa Islam”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Projects 95: Runa Islam'' SUMMARY..., I hereby determine that the objects to be included in the exhibition ``Projects 95: Runa...

  14. 78 FR 17744 - Culturally Significant Objects Imported for Exhibition Determinations: “Maya: Hidden Worlds...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Maya: Hidden Worlds Revealed... determine that the objects to be included in the exhibition ``Maya: Hidden Worlds Revealed,'' imported...

  15. 78 FR 45285 - Culturally Significant Objects Imported for Exhibition Determinations: “Egypt's Mysterious Book...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Egypt's Mysterious Book of the..., 2003), I hereby determine that the objects to be included in the exhibition ``Egypt's Mysterious...

  16. 78 FR 5556 - Culturally Significant Objects Imported for Exhibition Determinations: “Frida & Diego: Passion...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Frida & Diego: Passion, Politics and..., Politics and Painting,'' imported from abroad for temporary exhibition within the United States, are...

  17. 75 FR 66419 - Culturally Significant Objects Imported for Exhibition Determinations: “Object of Devotion...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Object of Devotion: Medieval English... objects to be included in the exhibition ``Object of Devotion: Medieval English Alabaster Sculpture...

  18. 76 FR 1660 - Culturally Significant Objects Imported for Exhibition Determinations: “Art in Cameroon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Art in Cameroon: Sculptural... ``Art in Cameroon: Sculptural Dialogues,'' imported from abroad for temporary exhibition within...

  19. 77 FR 2340 - Culturally Significant Objects Imported for Exhibition Determinations: “Snapshot: Painters and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Snapshot: Painters and Photography... Photography, Bonnard to Vuillard'' imported from abroad for temporary exhibition within the United States,...

  20. 75 FR 28848 - Culturally Significant Objects Imported for Exhibition Determinations: “The Original Copy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Original Copy: Photography of... hereby determine that the objects to be included in the exhibition ``The Original Copy: Photography...

  1. 78 FR 40544 - Culturally Significant Objects Imported for Exhibition Determinations: “New Photography 2013...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``New Photography 2013: Adam Broomberg..., 2003), I hereby determine that the objects to be included in the exhibition ``New Photography...

  2. 75 FR 82128 - Culturally Significant Objects Imported for Exhibition Determinations: “The Orient Expressed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Orient Expressed: Japan's... the exhibition ``The Orient Expressed: Japan's Influence on Western Art, 1854-1918,'' imported...

  3. Medial-Lateral Postural Control in Older Adults Exhibits Increased Stiffness and Damping

    PubMed Central

    Cenciarini, Massimo; Loughlin, Patrick J.; Sparto, Patrick J.; Redfern, Mark S.

    2016-01-01

    Older adults often exhibit increased co-contraction in response to a balance perturbation. This response is generally thought to enhance stability by increasing joint stiffness. We investigated the issue of increased stiffness in postural control by exposing seven older (75 ±5 y) and ten young (24 ± 3 y) adults to pseudo-random medial-lateral (ML) floor tilts, and then fitting the measured ML body sway data to a previously-developed postural control model that includes stiffness and damping parameters. Significant increases were found in both parameters in the older adults compared to the young adults. This concurrent increase in stiffness and damping is more stabilizing than an increase in stiffness alone, which can lead to resonances. PMID:19964728

  4. 78 FR 6398 - Culturally Significant Objects Imported for Exhibition Determinations: “Picasso Black and White”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-30

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Picasso Black and White'' AGENCY... pertaining to the exhibition ``Picasso Black and White.'' The referenced notice is corrected here to include... ``Picasso Black and White,'' imported from abroad for temporary exhibition within the United States, are...

  5. 78 FR 32000 - Culturally Significant Objects Imported for Exhibition Determinations: “Before and After the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-28

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Before and After the Horizon... the Horizon: Anishinaabe Artists of the Great Lakes,'' imported from abroad for temporary exhibition... exhibit objects at the National Museum of the American Indian, New York, New York, from on or about...

  6. 78 FR 44188 - Culturally Significant Objects Imported for Exhibition Determinations: “Before and After the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Before and After the Horizon... determinations made by the Department of State pertaining to the exhibition ``Before and After the Horizon... exhibition ``Before and after the Horizon: Anishinaabe Artists of the Great Lakes,'' imported from abroad...

  7. 77 FR 67725 - Culturally Significant Object Imported for Exhibition Determinations: “Michelangelo's David Apollo”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Michelangelo's David Apollo'' SUMMARY... object to be included in the exhibition ``Michelangelo's David Apollo,'' imported from abroad for... display of the exhibit object at the National Gallery of Art, Washington, DC, from on or about December...

  8. 77 FR 65245 - Culturally Significant Objects Imported for Exhibition Determinations: “Late Roman and Early...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-25

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Late Roman and Early Byzantine... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Late Roman and... exhibit objects at the The Art Institute of Chicago in Chicago, Illinois from on or about November...

  9. 77 FR 2118 - Culturally Significant Objects Imported for Exhibition Determinations: “The Steins Collect...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-13

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Steins Collect: Matisse, Picasso... Department of State pertaining to the exhibition ``The Steins Collect: Matisse, Picasso and the Parisian... determine that additional objects to be included in the exhibition ``The Steins Collect: Matisse,...

  10. 75 FR 59781 - Culturally Significant Objects Imported for Exhibition Determinations: “Imagining the Past in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Imagining the Past in France, 1250... Authority No. 236-3 of August 28, 2000, I hereby determine that the objects to be included in the exhibition ``Imagining the Past in France, 1250-1500,'' imported from abroad for temporary exhibition within the...

  11. 75 FR 1680 - Culturally Significant Objects Imported for Exhibition Determinations: “Roman Art”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Roman Art'' SUMMARY: Notice is... included in the exhibition ``Roman Art,'' imported from abroad for temporary exhibition within the United... the Metropolitan Museum of Art, New York, NY, from on or about January 2010 until on or about...

  12. 75 FR 43225 - Culturally Significant Objects Imported for Exhibition Determinations: “The Holocaust-Uniforms...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Holocaust--Uniforms, Canisters... ``The Holocaust--Uniforms, Canisters, and Shoes,'' imported from abroad for temporary exhibition within... objects as part of the permanent exhibit at the U.S. Holocaust Memorial Museum, Washington, DC, from on...

  13. 75 FR 27613 - Culturally Significant Objects Imported for Exhibition Determinations: “The Holocaust (Warsaw...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Holocaust (Warsaw Ghetto... that the documents to be included in the exhibition ``The Holocaust (Warsaw Ghetto),'' imported from... exhibition or display of the documents at the U.S. Holocaust Memorial Museum, Washington, DC, from on...

  14. 75 FR 41274 - Culturally Significant Objects Imported for Exhibition Determinations: “The World of Khubilai...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The World of Khubilai Khan: Chinese... Department of State pertaining to the exhibit ``From Xanadu to Dadu: The World of Khubilai Khan.'' The... exhibit name is now titled, ``The World of Khubilai Khan: Chinese Art in the Yuan Dynasty.'' Pursuant...

  15. 77 FR 4858 - Culturally Significant Objects Imported for Exhibition Determinations: “Byzantium and Islam: Age...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Byzantium and Islam: Age of... determinations made by ] the Department of State pertaining to the exhibition ``Byzantium and Islam: Age of... Islam: Age of Transition (7th-9th Century),'' imported from abroad for temporary exhibition within...

  16. 76 FR 78716 - Culturally Significant Objects Imported for Exhibition Determinations: “Hilda With Bluebells”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-19

    ... object to be included in the exhibition ``Hilda with Bluebells,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a loan... exhibit object at The Metropolitan Museum of Art, New York, NY, from on or about January 10, 2012,...

  17. 77 FR 34121 - Culturally Significant Objects Imported for Exhibition Determinations: “Lucian Freud: Portraits”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... object to be included in the exhibition ``Lucian Freud: Portraits,'' imported from abroad by The Modern... significance. The object is imported pursuant to a loan agreement with the foreign owners or custodians. I also determine that the exhibition or display of the exhibit object at The Modern Art Museum of Fort Worth...

  18. 77 FR 18295 - Culturally Significant Objects Imported for Exhibition Determinations: “Decree Stele”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ... object to be included in the exhibition ``Decree Stele'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object is imported pursuant to a loan... exhibit object at the Getty Villa, Pacific Palisades, CA, from on or about April 25, 2012, until on...

  19. Middle-aged adults exhibit altered spatial variations in Achilles tendon wave speed

    PubMed Central

    Slane, Laura Chernak; DeWall, Ryan; Martin, Jack; Lee, Kenneth; Thelen, Darryl G.

    2016-01-01

    The purpose of this study was to investigate spatial variations in measured wave speed in the relaxed and stretched Achilles tendons of young and middle-aged adults. Wave speed was measured from the distal Achilles tendon, soleus aponeurosis, medial gastrocnemius aponeurosis and medial gastrocnemius muscle in healthy young (n = 15, aged 25 ± 4 years) and middle-aged (n = 10, aged 49 ± 4 years) adults in resting, dorsiflexed and plantarflexed postures. In both age groups, Achilles tendon wave speed decreased proximally, with the lowest wave speed measured in the gastrocnemius aponeurosis. Measured wave speed increased with passive dorsiflexion, reflecting the strain-stiffening behavior of tendons. There were no significant aging effects on wave speed in the free tendon or soleus aponeurosis. However, a significant, inverse relationship between gastrocnemius aponeurosis wave speed and age was observed in the dorsiflexed posture. We also observed significantly lower wave speeds in the gastrocnemius muscles of middle-aged adults when compared with young adults. These results suggest that Achilles tendon compliance increases in a distal-to-proximal pattern, with middle-aged adults exhibiting greater compliance in the distal gastrocnemius muscle and tendinous structures. An age-related change in the spatial variation in Achilles tendon compliance could affect localised tissue deformation patterns and injury potential within the triceps surae muscle-tendon units. PMID:26020294

  20. 78 FR 53817 - Culturally Significant Objects Imported for Exhibition Determinations: “Venetian Glass by Carlo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Venetian Glass by Carlo Scarpa: The... April 15, 2003, I hereby determine that the objects to be included in the exhibition ``Venetian Glass...

  1. 75 FR 18252 - Culturally Significant Object Imported for Exhibition Determinations: “Through African Eyes: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Through African Eyes: The European in... 15, 2003 , I hereby determine that the object to be included in the exhibition ``Through African...

  2. 76 FR 56491 - Culturally Significant Objects Imported for Exhibition Determinations: “Adapting the Eye: An...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Adapting the Eye: An Archive of the... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Adapting the...

  3. 76 FR 5236 - Culturally Significant Objects Imported for Exhibition Determinations: “Pastel Portraits: Images...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Pastel Portraits: Images of 18th... ``Pastel Portraits: Images of 18th-Century Europe,'' imported from abroad for temporary exhibition...

  4. 77 FR 22630 - Culturally Significant Objects Imported for Exhibition Determinations: “The Printed Image in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Printed Image in China, 8th-21st... ``The Printed Image in China, 8th-21st Century,'' imported from abroad for temporary exhibition...

  5. 76 FR 77582 - Culturally Significant Objects Imported for Exhibition Determinations: “Beauty and Belief...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Beauty and Belief: Crossing Bridges... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Beauty...

  6. 78 FR 27470 - Culturally Significant Objects Imported for Exhibition Determinations: “Shaping Power: Luba...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Shaping Power: Luba Masterworks From... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Shaping...

  7. 76 FR 18291 - Culturally Significant Objects Imported for Exhibition Determinations: “Boris Mikhailov: Case...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Boris Mikhailov: Case History... Mikhailov: Case History,'' imported from abroad for temporary exhibition within the United States, are of... Art, New York, New York, from on or about May 26, 2011, until on or about September 5, 2011, and...

  8. 76 FR 53524 - Culturally Significant Objects Imported for Exhibition Determinations: “Light Years: Conceptual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Light Years: Conceptual Art and the..., 2003), I hereby determine that the objects to be included in the exhibition ``Light Years:...

  9. 77 FR 60506 - Culturally Significant Objects Imported for Exhibition Determinations: “Light and Shadows: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-03

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Light and Shadows: The Story of..., 2003), I hereby determine that certain of the objects to be included in the exhibition ``Light...

  10. 77 FR 54647 - Culturally Significant Objects Imported for Exhibition Determinations: “African Art, New York...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``African Art, New York, and the Avant..., 2003), I hereby determine that the objects to be included in the exhibition ``African Art, New...

  11. 78 FR 59080 - Culturally Significant Objects Imported for Exhibition Determinations: “Delacroix and the Matter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Delacroix and the Matter of Finish... determine that the objects to be included in the exhibition ``Delacroix and the Matter of Finish,''...

  12. 76 FR 58075 - Culturally Significant Objects Imported for Exhibition Determinations: “Rembrandt and Degas: Two...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Rembrandt and Degas: Two Young..., 2003), I hereby determine that the objects to be included in the exhibition ``Rembrandt and Degas:...

  13. 78 FR 50137 - Culturally Significant Objects Imported for Exhibition Determinations: “Chagall: Love, War, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Chagall: Love, War, and Exile... determine that the objects to be included in the exhibition ``Chagall: Love, War, and Exile,'' imported...

  14. 78 FR 61871 - Culturally Significant Objects Imported for Exhibition Determinations: “focus: Monika Baer” and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``focus: Monika Baer'' and ``Monika..., 2003), I hereby determine that the objects to be included in the exhibition ``focus: Monika Baer''...

  15. 75 FR 21385 - Culturally Significant Objects Imported for Exhibition Determinations: “Cleopatra: The Search for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Cleopatra: The Search for the Last... hereby determine that the objects to be included in the exhibition ``Cleopatra: The Search for the...

  16. 77 FR 61468 - Culturally Significant Objects Imported for Exhibition Determinations: “Matisse: In Search of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Matisse: In Search of True Painting... determine that the objects to be included in the exhibition ``Matisse: In Search of True...

  17. 76 FR 63701 - Culturally Significant Objects Imported for Exhibition Determinations: “Anglo-Saxon Hoard: Gold...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Anglo-Saxon Hoard: Gold From England..., 2003), I hereby determine that the objects to be included in the exhibition ``Anglo-Saxon Hoard:...

  18. 77 FR 25780 - Culturally Significant Objects Imported for Exhibition Determinations: “Gold, Jasper, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Gold, Jasper, and Carnelian: Johann... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Gold,...

  19. 78 FR 62354 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-18

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Dead Sea Scrolls: Life and Faith in Ancient Times'' Formerly Titled ``The Dead Sea Scrolls: Life and Faith in Biblical Times'' ACTION... exhibition ``The Dead Sea Scrolls: Life and Faith in Biblical Times.'' The referenced notice was corrected...

  20. 77 FR 64373 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Dead Sea Scrolls: Life and Faith in Ancient Times,'' Formerly Titled ``The Dead Sea Scrolls: Life and Faith in Biblical Times... the exhibition ``The Dead Sea Scrolls: Life and Faith in Biblical Times.'' The referenced notice...

  1. 78 FR 24462 - Culturally Significant Objects Imported for Exhibition; Determinations: “The Dead Sea Scrolls...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-25

    ... Culturally Significant Objects Imported for Exhibition; Determinations: ``The Dead Sea Scrolls: Life and Faith in Ancient Times'' Formerly Titled ``The Dead Sea Scrolls: Life and Faith in Biblical Times... the exhibition ``The Dead Sea Scrolls: Life and Faith in Biblical Times.'' The referenced notice...

  2. 76 FR 63341 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Dead Sea Scrolls: Life and Faith..., 2003), I hereby determine that the objects to be included in the exhibition ``The Dead Sea...

  3. 78 FR 16565 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Dead Sea Scrolls: Life and Faith in Ancient Times'' Formerly Titled ``The Dead Sea Scrolls: Life and Faith in Biblical Times'' ACTION... exhibition ``The Dead Sea Scrolls: Life and Faith in Biblical Times.'' The referenced notice was corrected...

  4. 78 FR 71021 - Culturally Significant Objects Imported for Exhibition Determinations: “Antonio Canova: The Seven...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Antonio Canova: The Seven Last Works... determine that the objects to be included in the exhibition ``Antonio Canova: The Seven Last...

  5. 75 FR 39724 - Culturally Significant Objects Imported for Exhibition Determinations: “Arcimboldo (1526-1593...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Arcimboldo (1526-1593): Nature and... hereby determine that the objects to be included in the exhibition ``Arcimboldo (1526-1593): Nature...

  6. 75 FR 7536 - Culturally Significant Objects Imported for Exhibition Determinations: “The Aztec Pantheon and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Aztec Pantheon and the Art... hereby determine that the objects to be included in the exhibition ``The Aztec Pantheon and the...

  7. 78 FR 11725 - Culturally Significant Objects Imported for Exhibition Determinations: “Claes Oldenburg: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Claes Oldenburg: The Street and The..., 2003), I hereby determine that the objects to be included in the exhibition ``Claes Oldenburg:...

  8. 76 FR 56865 - Culturally Significant Objects Imported for Exhibition Determinations: “Degas and the Nude”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Degas and the Nude'' SUMMARY: Notice... objects to be included in the exhibition ``Degas and the Nude,'' imported from abroad for...

  9. 76 FR 39974 - Culturally Significant Objects Imported for Exhibition Determinations: “Warhol: The Headlines”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ..., from on or about September 25, 2011, until on or about January 2, 2012, at The Andy Warhol Museum... Culturally Significant Objects Imported for Exhibition Determinations: ``Warhol: The Headlines'' SUMMARY..., I hereby determine that the objects to be included in the exhibition ``Warhol: The...

  10. 77 FR 38881 - Culturally Significant Objects Imported for Exhibition Determinations: “Regarding Warhol: Sixty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ...; then at the Andy Warhol Museum in Pittsburgh, Pennsylvania from on or about February 2, 2013 to on or... Culturally Significant Objects Imported for Exhibition Determinations: ``Regarding Warhol: Sixty Artists..., 2003), I hereby determine that the objects to be included in the exhibition ``Regarding Warhol:...

  11. 76 FR 77299 - Culturally Significant Objects Imported for Exhibition Determinations: “Van Gogh. Up Close”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Van Gogh. Up Close'' SUMMARY: Notice... objects to be included in the exhibition ``Van Gogh. Up Close.,'' imported from abroad for...

  12. 77 FR 46146 - Culturally Significant Objects Imported for Exhibition Determinations: “Shock of the News”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Shock of the News'' SUMMARY: Notice... objects to be included in the exhibition ``Shock of the News,'' imported from abroad for...

  13. 75 FR 61238 - Culturally Significant Objects Imported for Exhibition Determinations: “Expanding the Story With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Expanding the Story With Four Greek... ``Expanding the Story with Four Greek Vases,'' imported from abroad for temporary exhibition within the...

  14. 77 FR 17104 - Culturally Significant Objects Imported for Exhibition Determinations: “Ecstatic Alphabets/Heaps...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Ecstatic Alphabets/Heaps of Language... determine that the objects to be included in the exhibition ``Ecstatic Alphabets/Heaps of...

  15. 78 FR 79560 - Culturally Significant Objects Imported for Exhibition Determinations: “Khirbet el-Maqatir...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Khirbet el-Maqatir: History of a..., ``Khirbet el-Maqatir: History of a Biblical Site,'' imported from abroad for temporary exhibition within...

  16. 75 FR 15764 - Culturally Significant Objects Imported for Exhibition Determinations: “Gods of Angkor: Bronzes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Gods of Angkor: Bronzes From the... 15, 2003 , I hereby determine that the objects to be included in the exhibition ``Gods of...

  17. 77 FR 53959 - Culturally Significant Object Imported for Exhibition Determinations: “Dancing Into Dreams, Maya...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Dancing Into Dreams, Maya Vases From..., 2003), I hereby determine that the object to be included in the exhibition ``Dancing Into Dreams,...

  18. 76 FR 60112 - Culturally Significant Objects Imported for Exhibition Determinations: “Byzantium and Islam: Age...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Byzantium and Islam: Age of... Islam: Age of Transition (7th-9th Century),'' imported from abroad for temporary exhibition within the... Federal Register. FOR FURTHER INFORMATION CONTACT: For further information, including a list of...

  19. 76 FR 56864 - Culturally Significant Objects Imported for Exhibition Determinations: “Caravaggio and His...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Caravaggio and His Followers in Rome... determine that the objects to be included in the exhibition ``Caravaggio and His Followers in...

  20. 76 FR 20802 - Culturally Significant Object Imported for Exhibition Determinations: “The Capitoline Venus”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Culturally Significant Object Imported for Exhibition Determinations: ``The Capitoline Venus'' SUMMARY..., I hereby determine that the object to be included in the exhibition ``The Capitoline Venus... object is imported pursuant to a loan agreement with the foreign owner or custodian. I also...

  1. 77 FR 59701 - Culturally Significant Objects Imported for Exhibition Determinations: “Wari: Lords of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Wari: Lords of the Ancient Andes... determine that the objects to be included in the exhibition ``Wari: Lords of the Ancient Andes''...

  2. 78 FR 45286 - Culturally Significant Objects Imported for Exhibition Determinations: “Canterbury and St. Albans...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Canterbury and St. Albans: Treasures... St. Albans: Treasures from Church and Cloister,'' imported from abroad for temporary exhibition... State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: July 22, 2013. Ann...

  3. 79 FR 61125 - Culturally Significant Object Imported for Exhibition Determinations: “Delacroix's Greece on the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2014-10-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Delacroix's Greece on the Ruins of..., 2003), I hereby determine that the object to be included in the exhibition ``Delacroix's Greece on...

  4. 77 FR 56251 - Culturally Significant Objects Imported for Exhibition Determinations: “The Body Beautiful in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Body Beautiful in Ancient Greece... determine that the objects to be included in the exhibition ``The Body Beautiful in Ancient...

  5. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Finding of No Significant Environmental Impact I Exhibit I to Subpart G of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued... Program Pt. 1940, Subpt. G, Exh. I Exhibit I to Subpart G of Part 1940—Finding of No...

  6. Significant Individuals in Adolescence: Adolescent and Adult Perspectives.

    ERIC Educational Resources Information Center

    Tatar, Moshe

    1998-01-01

    Examines attitudes of Israeli adolescents and midlife adults about significant adults in their past. Results indicate that most choose a parent as the most significant relative in their adolescence, and females choose mothers more than males do. Adults attribute more negative characteristics to their parents and are more likely to mention teachers…

  7. 77 FR 38374 - Culturally Significant Objects Imported for Exhibition Determinations: “The Human Beast: German...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Human Beast: German...: German Expressionism at The San Diego Museum of Art'' imported from abroad for temporary...

  8. 78 FR 8682 - Culturally Significant Objects Imported for Exhibition Determinations: “Henri Labrouste...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Henri Labrouste: Structure Brought to Light'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the...

  9. 75 FR 5637 - Culturally Significant Objects Imported for Exhibition Determinations: “Architecture as Icon...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-03

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Architecture as Icon: Perception and... Icon: Perception and Representation of Architecture in Byzantine Art,'' imported from abroad...

  10. 77 FR 28923 - Culturally Significant Objects Imported for Exhibition Determinations: “Unearthed: Recent...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Unearthed: Recent Archeological...: Recent Archeological Discoveries from Northern China,'' imported from abroad for temporary...

  11. 75 FR 52385 - Culturally Significant Objects Imported for Exhibition Determinations: “Paintings From the Reign...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-25

    .... Correction In the Federal Register of August 26, 2008, in FR volume 73, page 50395, at the end of the..., concerning culturally significant objects imported for exhibition determinations. The document did not...

  12. 78 FR 48216 - Culturally Significant Objects Imported for Exhibition Determinations: “Balthus: Cats and Girls...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Balthus: Cats and Girls--Paintings... ``Balthus: Cats and Girls--Paintings and Provocations,'' imported from abroad for temporary...

  13. 77 FR 12352 - Culturally Significant Objects Imported for Exhibition Determinations: “Bellini, Titian and Lotto...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Bellini, Titian and Lotto: North... ``Bellini, Titian and Lotto: North Italian Paintings from the Accademia Carrara, Bergamo'' imported...

  14. 77 FR 52783 - Culturally Significant Objects Imported for Exhibition Determinations: “Dancing Around the Bride...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Dancing Around the Bride: Cage... ``Dancing Around the Bride: Cage, Cunningham, Johns, Rauschenberg, and Duchamp,'' imported from abroad...

  15. 76 FR 23642 - Culturally Significant Objects Imported for Exhibition Determinations: “Marajo: Ancient Ceramics...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Marajo: Ancient Ceramics at the... ``Marajo: Ancient Ceramics at the Mouth of the Amazon'' imported from abroad for temporary...

  16. 75 FR 21384 - Culturally Significant Objects Imported for Exhibition Determinations: “The Glory of Ukraine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Glory of Ukraine: Sacred Images... Ukraine: Sacred Images from the 11th to the 19th Centuries,'' imported from abroad for...

  17. 77 FR 51843 - Culturally Significant Objects Imported for Exhibition Determinations: “Plants of Virtue and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Plants of Virtue and Rocks by a... State pertaining to the object ``Plants of Virtue and Rocks by a Stream'' by Shitao. The...

  18. 77 FR 48582 - Culturally Significant Objects Imported for Exhibition Determinations: “Plants of Virtue and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Plants of Virtue and Rocks by a... ``Plants of Virtue and Rocks by a Stream'' by Shitao to be imported by The Santa Barbara Museum of Art...

  19. 77 FR 56697 - Culturally Significant Objects Imported for Exhibition Determinations: “The English Prize: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The English Prize: The Capture of... ``The English Prize: The Capture of the Westmorland, an Episode of the Grand Tour,'' imported...

  20. 77 FR 26067 - Culturally Significant Objects Imported for Exhibition Determinations: “American Encounters...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``American Encounters: Thomas Cole and... Encounters: Thomas Cole and the American Landscape,'' imported from abroad by the High Museum of Art...

  1. 77 FR 48582 - Culturally Significant Objects Imported for Exhibition Determinations: Terracotta Bell-Krater...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: Terracotta Bell-Krater Attributed to..., 2003), I hereby determine that the object Terracotta Bell-Krater attributed to the Altamura...

  2. 76 FR 81004 - Culturally Significant Objects Imported for Exhibition Determinations: “Woman in Blue, Against...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-27

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Woman in Blue, Against Blue Water..., 2003), I hereby determine that the object ``Woman in Blue, Against Blue Water'' by Edvard...

  3. 78 FR 71022 - Culturally Significant Objects Imported for Exhibition Determinations: “Christopher Williams: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Christopher Williams: The Production... authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order...

  4. 77 FR 41473 - Culturally Significant Objects Imported for Exhibition Determinations: “Lion Attacking a Horse”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Lion Attacking a Horse'' SUMMARY... object entitled ``Lion Attacking a Horse,'' to be imported by The J. Paul Getty Museum from abroad...

  5. 77 FR 7655 - Culturally Significant Objects Imported for Exhibition Determinations: “Inventing the Modern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Inventing the Modern World: Decorative Arts at the World's Fairs, 1851-1939'' SUMMARY: Notice is hereby given of the following... ``Inventing the Modern World: Decorative Arts at the World's Fairs, 1851-1939'' imported from abroad...

  6. 77 FR 51606 - Culturally Significant Objects Imported for Exhibition Determinations: “Extravagant Inventions...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... Furniture of the Roentgens,'' Formerly Titled ``Seductive Luxury and Innovation: The Furniture of Abraham... State pertaining to the exhibition ``Seductive Luxury and Innovation: The Furniture of Abraham and David... States, are of cultural significance. The additional objects are imported pursuant to loan...

  7. 78 FR 19062 - Culturally Significant Objects Imported for Exhibition Determinations: “Hans Richter: Encounters”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-28

    ... ``Hans Richter: Encounters.'' The referenced notice is corrected to accommodate an additional object to... appropriate, Delegation of Authority No. 257 of April 15, 2003), I hereby determine that the additional object... exhibition within the United States, is of cultural significance. The additional object is imported...

  8. 77 FR 65603 - Culturally Significant Objects Imported for Exhibition Determinations: “Inventing Abstraction...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-29

    ... that the exhibition or display of the exhibit objects at the Museum of Modern Art, New York, New York... exhibition or display of one of the objects at the Los Angeles County Museum of Art, Los Angeles,...

  9. Self-Concept, Anxiety, and Knowledge Exhibited by Adult Children of Alcoholics and Adult Children of Non Alcoholics.

    ERIC Educational Resources Information Center

    Webb, Wanda; And Others

    1992-01-01

    Compared 59 adult children of alcoholics (ACOAs) and 175 adult children of nonalcoholics (non-ACOAs) on self-concept, anxiety, and their knowledge of ACOA issues. Found no significant differences on self-concept and knowledge of ACOA issues. Significant differences were found on levels of anxiety, such that ACOAs had higher anxiety levels than did…

  10. 78 FR 51803 - Culturally Significant Objects Imported for Exhibition Determinations: “Léger: Modern Art and the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``L ger: Modern Art and the Metropolis... determine that the objects to be included in the exhibition ``L ger: Modern Art and the Metropolis... that the exhibition or display of the exhibit objects at the Philadelphia Museum of Art,...

  11. Neocortical slices from adult chronic epileptic rats exhibit discharges of higher voltages and broader spread.

    PubMed

    Serafini, R; Dettloff, S; Loeb, J A

    2016-05-13

    Much of the current understanding of epilepsy mechanisms has been built on data recorded with one or a few electrodes from temporal lobe slices of normal young animals stimulated with convulsants. Mechanisms of adult, extratemporal, neocortical chronic epilepsy have not been characterized as much. A more advanced understanding of epilepsy mechanisms can be obtained by recording epileptiform discharges simultaneously from multiple points of an epileptic focus so as to define their sites of initiation and pathways of spreading. Brain slice recordings can characterize epileptic mechanisms in a simpler, more controlled preparation than in vivo. Yet, the intrinsic hyper-excitability of a chronic epileptic focus may not be entirely preserved in slices following the severing of connections in slice preparation. This study utilizes recordings of multiple electrode arrays to characterize which features of epileptic hyper-excitability present in in vivo chronic adult neocortical epileptic foci are preserved in brain slices. After tetanus toxin somatosensory cortex injections, adult rats manifest chronic spontaneous epileptic discharges both in the injection site (primary focus) and in the contralateral side (secondary focus). We prepared neocortical slices from these epileptic animals. When perfused with 4-Aminopyridine in a magnesium free medium, epileptic rat slices exhibit higher voltage discharges and broader spreading than control rat slices. Rates of discharges are similar in slices of epileptic and normal rats, however. Ictal and interictal discharges are distributed over most cortical layers, though with significant differences between primary and secondary foci. A chronic neocortical epileptic focus in slices does not show increased spontaneous pacemakers initiating epileptic discharges but shows discharges with higher voltages and broader spread, consistent with an enhanced synchrony of cellular and synaptic generators over wider surfaces. PMID:26892299

  12. 75 FR 30459 - Culturally Significant Objects Imported for Exhibition Determinations: “Dynasty and Divinity: Ife...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... determine that the exhibition or display of the exhibit objects at the Museum of Fine Arts, Houston, TX, from on or about September 19, 2010, until on or about January 9, 2011; at the Virginia Museum of...

  13. The adaptive significance of adult neurogenesis: an integrative approach

    PubMed Central

    Konefal, Sarah; Elliot, Mick; Crespi, Bernard

    2013-01-01

    Adult neurogenesis in mammals is predominantly restricted to two brain regions, the dentate gyrus (DG) of the hippocampus and the olfactory bulb (OB), suggesting that these two brain regions uniquely share functions that mediate its adaptive significance. Benefits of adult neurogenesis across these two regions appear to converge on increased neuronal and structural plasticity that subserves coding of novel, complex, and fine-grained information, usually with contextual components that include spatial positioning. By contrast, costs of adult neurogenesis appear to center on potential for dysregulation resulting in higher risk of brain cancer or psychological dysfunctions, but such costs have yet to be quantified directly. The three main hypotheses for the proximate functions and adaptive significance of adult neurogenesis, pattern separation, memory consolidation, and olfactory spatial, are not mutually exclusive and can be reconciled into a simple general model amenable to targeted experimental and comparative tests. Comparative analysis of brain region sizes across two major social-ecological groups of primates, gregarious (mainly diurnal haplorhines, visually-oriented, and in large social groups) and solitary (mainly noctural, territorial, and highly reliant on olfaction, as in most rodents) suggest that solitary species, but not gregarious species, show positive associations of population densities and home range sizes with sizes of both the hippocampus and OB, implicating their functions in social-territorial systems mediated by olfactory cues. Integrated analyses of the adaptive significance of adult neurogenesis will benefit from experimental studies motivated and structured by ecologically and socially relevant selective contexts. PMID:23882188

  14. 77 FR 77178 - Culturally Significant Objects Imported for Exhibition Determinations: “Pre-Raphaelites...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ..., 2003), I hereby determine that the objects to be included in the exhibition ``Pre-Raphaelites... foreign owners or custodians. I also determine that the exhibition or display of the exhibit objects at... interest. I have ordered that Public Notice of these Determinations be published in the Federal...

  15. 77 FR 74048 - Culturally Significant Object Imported for Exhibition Determinations: “Connecting Collections...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    ... Connections. 50 Years of Pre-Columbian Art at Dumbarton Oaks'' SUMMARY: Notice is hereby given of the... exhibition ``Connecting Collections: Collecting Connections. 50 Years of Pre-Columbian Art at Dumbarton Oaks... that the exhibition or display of the exhibit object at Dumbarton Oaks, Washington, DC, from on...

  16. 78 FR 13930 - Culturally Significant Object Imported for Exhibition Determinations: “Portrait of Francesco I d...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-01

    ... Culturally Significant Object Imported for Exhibition Determinations: ``Portrait of Francesco I d'Este... determine that the object to be included in the exhibition ``Portrait of Francesco I d'Este,'' imported from abroad for temporary exhibition within the United States, is of cultural significance. The object...

  17. 76 FR 40419 - Culturally Significant Objects Imported for Exhibition Determinations: “Prints and the Pursuit of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Prints and the Pursuit of Knowledge... the exhibition ``Prints and the Pursuit of Knowledge in Early Modern Europe,'' imported from...

  18. 76 FR 58075 - Culturally Significant Objects Imported for Exhibition Determinations: “Sanja Iveković: Sweet...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Sanja Ivekovi : Sweet Violence... determine that the objects to be included in the exhibition ``Sanja Ivekovi : Sweet Violence,''...

  19. 76 FR 58074 - Culturally Significant Objects Imported for Exhibition Determinations: “Sanja Iveković: Sweet...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Sanja Ivekovi : Sweet Violence... determine that the objects to be included in the exhibition ``Sanja Ivekovi : Sweet Violence,''...

  20. 75 FR 53730 - Culturally Significant Objects Imported for Exhibition Determinations: “Richard Hawkins-Third Mind”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Richard Hawkins--Third Mind... Hawkins--Third Mind,'' imported from abroad for temporary exhibition within the United States, are...

  1. 75 FR 74126 - Culturally Significant Objects Imported for Exhibition Determinations: “Picasso: Guitars 1912-1914”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Picasso: Guitars 1912-1914'' SUMMARY..., I hereby determine that the objects to be included in the exhibition ``Picasso: Guitars...

  2. 75 FR 41274 - Culturally Significant Objects Imported for Exhibition Determinations: “The Art of Ancient Greek...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Art of Ancient Greek Theater... Ancient Greek Theater,'' imported from abroad for temporary exhibition within the United States, are...

  3. 78 FR 48216 - Culturally Significant Objects Imported for Exhibition Determinations: “Heaven and Earth: Art of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Heaven and Earth: Art of Byzantium... the exhibition ``Heaven and Earth: Art of Byzantium from Greek Collections,'' imported from abroad...

  4. Education for Older Adults: A Synthesis of Significant Data.

    ERIC Educational Resources Information Center

    Ventura-Merkel, Catherine; Worthy, Edmund H., Jr.

    Despite the record numbers of older learners today and the probable future growth of these numbers, older people today are underrepresented in adult education. Furthermore, a significant segment of older people has serious educational deficiencies hindering their ability to cope in the contemporary world. Surveys show that the characteristics that…

  5. Inviting Learning: An Exhibition of Risk and Enrichment in Adult Education Practice.

    ERIC Educational Resources Information Center

    Willis, Peter

    This study explores adult education practice by using an expressive research method based on using the metaphor of an exhibition as a vehicle for presenting and reflecting on seven episodes in the researcher's two decades of teaching at various locations throughout Australia. In accordance with the metaphor, the study report contains the following…

  6. 75 FR 53013 - Culturally Significant Objects Imported for Exhibition Determinations: “Treasures of Heaven...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ..., and Devotion in Medieval Europe'' SUMMARY: Notice is hereby given of the following determinations... the exhibition ``Treasures of Heaven: Saints, Relics, and Devotion in Medieval Europe,'' imported...

  7. 77 FR 61045 - Culturally Significant Objects Imported for Exhibition Determinations: “China's Terracotta...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ... First Emperor's Legacy'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to... Terracotta Warriors: The First Emperor's Legacy,'' imported from abroad for temporary exhibition within...

  8. 76 FR 53524 - Culturally Significant Objects Imported for Exhibition Determinations: “Mirror of the Buddha...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... Portraits From Tibet'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the...: Early Portraits from Tibet,'' imported from abroad for temporary exhibition within the United...

  9. 76 FR 28499 - Culturally Significant Objects Imported for Exhibition Determinations: “Picasso and Braque: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... Experiment'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... ``Picasso and Braque: The Cubist Experiment,'' imported from abroad for temporary exhibition within...

  10. 75 FR 20873 - Culturally Significant Objects Imported for Exhibition Determinations: “The Glory of Ukraine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... Treasures and Lost Civilizations'' SUMMARY: Notice is hereby given of the following determinations: Pursuant... Ukraine: Golden Treasures and Lost Civilizations,'' imported from abroad for temporary exhibition...

  11. 75 FR 71787 - Culturally Significant Objects Imported for Exhibition Determinations: “Salvator Rosa: Bandits...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... and Magic'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... ``Salvator Rosa: Bandits, Wilderness and Magic'', imported from abroad for temporary exhibition within...

  12. 75 FR 9013 - Culturally Significant Objects Imported for Exhibition Determinations: “Vienna Circa 1780: An...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-26

    ... Silver Service Rediscovered'' SUMMARY: Notice is hereby given of the following determinations: Pursuant...: An Imperial Silver Service Rediscovered,'' imported from abroad for temporary exhibition within...

  13. 78 FR 23623 - Culturally Significant Objects Imported for Exhibition Determinations: “American Encounters...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-19

    ... and Everyday Life'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the...: Genre Painting and Everyday Life,'' imported from abroad for temporary exhibition within the...

  14. 78 FR 51803 - Culturally Significant Objects Imported for Exhibition Determinations: “Charles Marville...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... Paris'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority...: Photographer of Paris,'' imported from abroad for temporary exhibition within the United States, are...

  15. 76 FR 28121 - Culturally Significant Objects Imported for Exhibition Determinations: “National Geographic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-13

    ... Earth'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... ``National Geographic Treasures of the Earth'' imported from abroad for temporary exhibition within...

  16. 77 FR 37730 - Culturally Significant Objects Imported for Exhibition Determinations: “Nomads and Networks: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... and Culture of Kazakhstan'' SUMMARY: Notice is hereby given of the following determinations: Pursuant... Networks: The Ancient Art and Culture of Kazakhstan,'' imported from abroad for temporary exhibition...

  17. 75 FR 47338 - Culturally Significant Objects Imported for Exhibition Determinations: “The Nepalese Legacy in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... Painting'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... ``The Nepalese Legacy in Tibetan Painting,'' imported from abroad for temporary exhibition within...

  18. 76 FR 60113 - Culturally Significant Objects Imported for Exhibition Determinations: “Masters of Venice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... Paintings of Passion and Power from Kunsthistorisches Museum, Vienna'' SUMMARY: Notice is hereby given of... included in the exhibition ``Masters of Venice: Renaissance Paintings of Passion and Power...

  19. 78 FR 56980 - Culturally Significant Objects Imported for Exhibition Determinations: “Francesco Vanni: Art in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... Renaissance Siena'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... Late Renaissance Siena,'' imported from abroad for temporary exhibition within the United States,...

  20. 78 FR 55772 - Culturally Significant Objects Imported for Exhibition Determinations: “American Adversaries...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-11

    ... Copley in a Transatlantic World'' SUMMARY: Notice is hereby given of the following determinations... Adversaries: West and Copley in a Transatlantic World,'' imported from abroad for temporary exhibition...

  1. 74 FR 44894 - Culturally Significant Objects Imported for Exhibition Determinations: “Heroes: Mortals and Myths...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2009-08-31

    ... Greece'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... hereby determine that the objects in the exhibition: ``Heroes: Mortals and Myths in Ancient...

  2. 77 FR 15839 - Culturally Significant Objects Imported for Exhibition Determinations: “Making a Presence: F...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-16

    ... Artistic Photography'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the.... Holland Day in Artistic Photography,'' imported from abroad for temporary exhibition within the...

  3. 77 FR 22833 - Culturally Significant Objects Imported for Exhibition Determinations: “Edouard Vuillard: A...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-17

    ... Muses, 1890- 1940'' ACTION: Notice, correction. SUMMARY: On April 9, 2012, notice was published on page... pertaining to the exhibit ``Edouard Vuillard: A Painter and His Muses, 1890-1940.'' The reference notice is... exhibition ``Edouard Vuillard: A Painter and His Muses, 1890-1940,'' imported from abroad for...

  4. 77 FR 4614 - Culturally Significant Objects Imported for Exhibition Determinations: “Children of the Plumed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-30

    ... October 1, 1999, and Delegation of Authority No. 236-3 of August 28, 2000 (and, as appropriate, Delegation... or about April 1, 2012, until on or about July 1, 2012, and then exhibition or display of the exhibit...: (202) 632-6473). The mailing address is U.S. Department of State, SA-5, L/PD, Fifth Floor (Suite...

  5. 75 FR 53731 - Culturally Significant Objects Imported for Exhibition Determinations: “Sheila Hicks: 50 Years”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... that the exhibition or display of the exhibit objects at the Addison Gallery of American Art, Phillips... Institute of Contemporary Art, University of Pennsylvania, Philadelphia, PA, from on or about March 25, 2011, until on or about August 7, 2011; at the Mint Museum Craft + Design, Charlotte, NC, from on or...

  6. 78 FR 4972 - Culturally Significant Objects Imported for Exhibition Determinations: “Nicolai Fechin”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-23

    ...On April 4, 2012, notice was published on page 20476 of the Federal Register (volume 77, number 65) of determinations made by the Department of State pertaining to the exhibition ``Nicolai Fechin.'' The referenced notice is corrected here to include additional objects as part of the exhibition. Notice is hereby given of the following determinations: Pursuant to the authority vested in me by......

  7. 77 FR 46554 - Culturally Significant Objects Imported for Exhibition Determinations: “Nicolai Fechin”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-03

    ...On April 4, 2012, notice was published on page 20476 of the Federal Register (volume 77, number 65) of determinations made by the Department of State pertaining to the exhibition ``Nicolai Fechin.'' The referenced notice is corrected here to include additional objects as part of the exhibition. Notice is hereby given of the following determinations: Pursuant to the authority vested in me by......

  8. 78 FR 52601 - Culturally Significant Objects Imported for Exhibition Determinations: “Koloman Moser”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ...On May 2, 2013, notice was published on page 25780 of the Federal Register (volume 78, number 85) of determinations made by the Department of State pertaining to the exhibition ``Koloman Moser.'' The referenced notice is corrected here to include additional objects as part of the exhibition. Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the......

  9. 78 FR 26682 - Culturally Significant Objects Imported for Exhibition Determinations: “Hall of Ancient Egypt”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-07

    ...On April 4, 2013, notice was published on page 20372 of the Federal Register (volume 78, number 65) of determinations made by the Department of State pertaining to the exhibition ``Hall of Ancient Egypt.'' The referenced notice is corrected here to include additional objects as part of the exhibition. Notice is hereby given of the following determinations: Pursuant to the authority vested in......

  10. 78 FR 14619 - Culturally Significant Objects Imported for Exhibition Determinations: “Sicily: Art and Invention...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... Greece and Rome'' ACTION: Notice, correction. SUMMARY: On September 5, 2012, notice was published on page... pertaining to the exhibit ``Sicily: Art and Invention Between Greece and Rome.'' The referenced notice is... and Invention Between Greece and Rome,'' imported from abroad for temporary exhibition within...

  11. 77 FR 26599 - Culturally Significant Objects Imported for Exhibition Determinations: “The Artist in the Garden”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Artist in the Garden'' SUMMARY... objects to be included in the exhibition ``The Artist in the Garden'' imported from abroad for temporary... exhibit objects at The New York Botanical Garden, Bronx, NY, from on or about May 19, 2012, until on...

  12. Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions

    PubMed Central

    2012-01-01

    Background Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independent evolution between these species. For a given set of human disease related genes, it is therefore important to determine if functional equivalency has been retained between species. In this study we test the hypothesis that cancer associated genes have different patterns of substitution akin to adaptive evolution in different mammal lineages. Results Our analysis of the current literature and colon cancer databases identified 22 genes exhibiting colon cancer associated germline mutations. We identified orthologs for these 22 genes across a set of high coverage (>6X) vertebrate genomes. Analysis of these orthologous datasets revealed significant levels of positive selection. Evidence of lineage-specific positive selection was identified in 14 genes in both ancestral and extant lineages. Lineage-specific positive selection was detected in the ancestral Euarchontoglires and Hominidae lineages for STK11, in the ancestral primate lineage for CDH1, in the ancestral Murinae lineage for both SDHC and MSH6 genes and the ancestral Muridae lineage for TSC1. Conclusion Identifying positive selection in the Primate, Hominidae, Muridae and Murinae lineages suggests an ancestral functional shift in these genes between the rodent and primate lineages. Analyses such as this, combining evolutionary theory and predictions - along with medically relevant data, can thus provide us with important clues for modeling human diseases. PMID:22788692

  13. 75 FR 45195 - Culturally Significant Objects Imported for Exhibition Determinations: “Literary Lives: Portraits...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... Crawford Art Gallery and Abbey Theatre, Ireland'' SUMMARY: Notice is hereby given of the following judicial... Gallery and Abbey Theatre, Ireland,'' imported from abroad for temporary exhibition within the...

  14. 75 FR 54691 - Culturally Significant Objects Imported for Exhibition Determinations: “The Vorticists: Rebel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... London and New York, 1914-18'' SUMMARY: Notice is hereby given of the following determinations: Pursuant... the exhibition ``The Vorticists: Rebel Artists in London and New York, 1914-18,'' imported from...

  15. 78 FR 61981 - Culturally Significant Objects Imported for Exhibition Determinations: “Anders Zorn: Sweden's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-08

    ... Francisco, CA, from on or about November 9, 2013, until on or about February 2, 2014; the National Academy... additional exhibitions or venues yet to be determined, is in the national interest. I have ordered...

  16. 77 FR 7229 - Culturally Significant Objects Imported for Exhibition Determinations: “Nomads and Networks: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-10

    ... Networks: The Ancient Art and Culture of Kazakhstan,'' imported from abroad for temporary exhibition within... objects at the Institute for the Study of the Ancient World, New York University, New York, New York,...

  17. 77 FR 50542 - Culturally Significant Objects Imported for Exhibition Determinations: “New Photography 2012...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ..., Birdhead (Ji Weiyu and Song Tao), Anne Collier, Zoe Crosher, and Shirana Shahbazi'' Summary: Notice is... objects to be included in the exhibition ``New Photography 2012: Michele Abeles, Birdhead (Ji Weiyu...

  18. 77 FR 21142 - Culturally Significant Objects Imported for Exhibition Determinations: “Edouard Vuillard: A...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-09

    ... Muses, 1890- 1940'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... Painter and His Muses, 1890-1940,'' imported from abroad for temporary exhibition within the United...

  19. 75 FR 51518 - Culturally Significant Objects Imported for Exhibition Determinations: “Picasso: Masterpieces...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-20

    ... National Picasso, Paris'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... agreement with the foreign owner or custodian. I also determine that the exhibition or display of...

  20. 78 FR 62326 - Culturally Significant Objects Imported for Exhibition Determinations: “Toulouse-Lautrec and La...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-16

    ...: Paris 1880- 1910'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... the exhibition ``Toulouse-Lautrec and La Vie Moderne: Paris 1880-1910,'' imported from abroad...

  1. 77 FR 24554 - Culturally Significant Objects Imported for Exhibition; Determinations: “Quay Brothers: On...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... Pharmacist's Prescription for Lip-Reading Puppets'' AGENCY: State Department. ACTION: Notice. SUMMARY: Notice... Lip-Reading Puppets'' imported from abroad for temporary exhibition within the United States, are...

  2. 76 FR 36166 - Culturally Significant Objects Imported for Exhibition; Determinations: “Gabriel von Max: Be...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ... and Phantasms of the Soul'' SUMMARY: Notice is hereby given of the following determinations: Pursuant... the exhibition ``Gabriel von Max: Be-Tailed Cousins and Phantasms of the Soul,'' imported from...

  3. 76 FR 12786 - Culturally Significant Objects Imported for Exhibition Determinations: “Poetry in Clay: Korean...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... Ceramics from the Leeum, Samsung Museum of Art'' SUMMARY: Notice is hereby given of the following... objects to be included in the exhibition ``Poetry in Clay: Korean Buncheong Ceramics from the...

  4. 76 FR 68256 - Culturally Significant Objects Imported for Exhibition Determinations: “Shapeshifting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... Native American Art'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the...: Transformations in Native American Art,'' imported from abroad for temporary exhibition within the United...

  5. 76 FR 20802 - Culturally Significant Objects Imported for Exhibition Determinations: “Ancestors of the Lake...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... Sentani and Humboldt Bay'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to... the exhibition ``Ancestors of the Lake: Art from Lake Sentani and Humboldt Bay,'' imported from...

  6. 77 FR 12103 - Culturally Significant Objects Imported for Exhibition Determinations: “Colorful Realm: Japanese...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-28

    ...-Flower Paintings by It Jakuch (1716-1800)'' SUMMARY: Notice is hereby given of the following... exhibition ``Colorful Realm: Japanese Bird-and-Flower Paintings by It Jakuch (1716-1800),'' imported...

  7. 77 FR 57637 - Culturally Significant Objects Imported for Exhibition Determinations: “The Place of Provenance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... Styles in Tibetan Painting'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to... the exhibition ``The Place of Provenance--Regional Styles in Tibetan Painting,'' imported from...

  8. 78 FR 33465 - Culturally Significant Objects Imported for Exhibition Determinations: “Interwoven Globe: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... Textile Trade, 1500- 1800'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to...: The Worldwide Textile Trade, 1500-1800,'' imported from abroad for temporary exhibition within...

  9. 75 FR 7536 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... Changed the World'' Summary: Notice is hereby given of the following determinations: Pursuant to the... Changed the World,'' imported from abroad for temporary exhibition within the United States, are...

  10. 76 FR 59767 - Culturally Significant Objects Imported for Exhibition Determinations: “Contested Visions in the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-27

    ... Colonial World'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... Spanish Colonial World'' imported from abroad for temporary exhibition within the United States, are...

  11. 78 FR 60994 - Culturally Significant Objects Imported for Exhibition Determinations: “In Grand Style...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-02

    ... Korean Art During the Joseon Dynasty'' SUMMARY: Notice is hereby given of the following determinations...: Celebrations in Korean Art during the Joseon Dynasty,'' imported from abroad for temporary exhibition...

  12. 77 FR 54647 - Culturally Significant Objects Imported for Exhibition Determinations: “Sicily: Art and Invention...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ... Greece and Rome'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... Between Greece and Rome,'' imported from abroad for temporary exhibition within the United States, are...

  13. 78 FR 3067 - Culturally Significant Objects Imported for Exhibition Determinations: “Looking East: Rubens's...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-15

    ... With Asia'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... Encounter with Asia,'' imported from abroad for temporary exhibition within the United States, are...

  14. 76 FR 49832 - Culturally Significant Object Imported for Exhibition Determinations: “Warhol: The Headlines”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ...On July 7, 2011, notice was published on page 39974 of the Federal Register (Volume 76, No. 130) of determinations made by the Department of State pertaining to the exhibition, ``Warhol: The Headlines.'' The referenced notice is corrected to add one additional object to be included in the exhibition. Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C.......

  15. 77 FR 53959 - Culturally Significant Objects Imported for Exhibition Determinations: “Roads of Arabia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-04

    ... History of the Kingdom of Saudi Arabia'' SUMMARY: Notice is hereby given of the following determinations...: Archaeology and the History of the Kingdom of Saudi Arabia,'' imported from abroad for temporary exhibition... or about June 30, 2014; and/or the San Francisco Asian Art Museum in San Francisco, California...

  16. 75 FR 57825 - Culturally Significant Objects Imported for Exhibition Determinations: “Ancient Chinese Bronzes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... Shouyang Studio: The Katherine and George Fan Collection'' SUMMARY: Notice is hereby given of the following... and George Fan Collection,'' imported from abroad for temporary exhibition within the United States... 5H03), Washington, DC 20522-0505. Dated: September 16, 2010. Ann Stock, Assistant Secretary, Bureau...

  17. 76 FR 53993 - Culturally Significant Objects Imported for Exhibition Determinations: “New Photography 2011...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ..., Moyra Davey, George Georgiou, Deana Lawson, Doug Rickard, Viviane Sassen'' SUMMARY: Notice is hereby... objects to be included in the exhibition ``New Photography 2011: Zhang Dali, Moyra Davey, George Georgiou... 5H03), Washington, DC 20522-0505. ] Dated: August 24, 2011. J. Adam Ereli, Principal Deputy...

  18. 75 FR 8424 - Culturally Significant Objects Imported for Exhibition Determinations: “Leaves From an Austrian...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-24

    ..., et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No. 236 of... on or about June 1, 2010, until on or about June 1, 2012, and at possible additional exhibitions or...- 5, L/PD, Fifth Floor, Washington, DC 20522-0505. Dated: February 17, 2010. Maura M. Pally,...

  19. 77 FR 71472 - Culturally Significant Objects Imported for Exhibition Determinations: A Hellenistic “Herakles...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-30

    ..., et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999... January 1, 2023, and at possible additional exhibitions or venues yet to be determined, is in the national...: 202- 632-6467). The mailing address is U.S. Department of State, SA-5, L/PD, Fifth Floor (Suite...

  20. 77 FR 53248 - Culturally Significant Objects Imported for Exhibition Determinations: “Mantegna to Matisse...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    .... 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and... exhibit objects at The Frick Collection in New York, New York from on or about October 1, 2012, until on.... Department of State (telephone: 202- 632-6473). The mailing address is U.S. Department of State, SA-5,...

  1. 75 FR 37521 - Culturally Significant Objects Imported for Exhibition Determinations: “Eton College Myers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ..., et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999... Johns Hopkins University, Baltimore, Maryland, from on or about ] August 1, 2010, until on or about August 1, 2025, and at possible additional exhibitions or venues yet to be determined, is in the...

  2. 78 FR 24288 - Culturally Significant Objects Imported for Exhibition Determinations: “Frida Kahlo, Diego Rivera...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Masterpieces of Modern Mexico: The Jacques and Natasha Gelman Collection'' SUMMARY: Notice is hereby given of... included in the exhibition ``Frida Kahlo, Diego Rivera, and Masterpieces of Modern Mexico: The Jacques and...-Atkins Museum of Art, Kansas City, Missouri, from on or about June 1, 2013, until on or about August...

  3. 77 FR 32168 - Culturally Significant Object Imported for Exhibition Determinations: “Elegance and Refinement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ...-Life Paintings of Willem van Aelst'' AGENCY: Department of State. ACTION: Notice, correction. SUMMARY... Refinement: The Still-Life Paintings of Willem van Aelst.'' The referenced notice is corrected here to... in the exhibition ``Elegance and Refinement: The Still-Life Paintings of Willem van Aelst,''...

  4. 75 FR 7536 - Culturally Significant Objects Imported for Exhibition Determinations: “Hendrick Avercamp (1585...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... Little Ice Age'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... Little Ice Age,'' imported from abroad for temporary exhibition within the United States, are of cultural... these Determinations be published in the Federal Register. FOR FURTHER INFORMATION CONTACT: For...

  5. 75 FR 54692 - Culturally Significant Objects Imported for Exhibition Determinations: “Van Gogh, Gauguin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ... Beyond: Post- Impressionist Masterpieces From the Mus e d'Orsay'' SUMMARY: Notice is hereby given of the... Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No... that the objects to be included in the exhibition ``Van Gogh, Gauguin, C zanne, and Beyond:...

  6. Astronomy's New Messengers: A traveling exhibit to reach out to a young adult audience

    NASA Astrophysics Data System (ADS)

    Cavaglià, Marco; Hendry, Martin; Márka, Szabolcs; Reitze, David H.; Riles, Keith

    2010-05-01

    The Laser Interferometer Gravitational-wave Observatory exhibit Astronomy's New Messengers: Listening to the Universe with Gravitational Waves is traveling to colleges, universities, museums and other public institutions throughout the United States. In 2010, an extended version of this exhibit will appear in a New York City venue that is accessible to a large and diverse cross section of the general public. Astronomy's New Messengers primarily communicates with an adolescent and young adult audience, potentially inspiring them into the field of science. Acknowledging that this audience is traditionally a difficult one to attract, the exhibit publicly announces itself in a charismatic fashion to reach its principal goals of broadening the community of people interested in science and encouraging interest in science among young people.

  7. Imatinib Treatment Causes Substantial Transcriptional Changes in Adult Schistosoma mansoni In Vitro Exhibiting Pleiotropic Effects

    PubMed Central

    Oliveira, Katia C.; Dissous, Colette; Cailliau, Katia; Marhöfer, Richard J.; Selzer, Paul M.; Verjovski-Almeida, Sergio; Grevelding, Christoph G.

    2014-01-01

    Background Schistosome parasites cause schistosomiasis, one of the most important infectious diseases worldwide. For decades Praziquantel (PZQ) is the only drug widely used for controlling schistosomiasis. The absence of a vaccine and fear of PZQ resistance have motivated the search for alternatives. Studies on protein kinases (PKs) demonstrated their importance for diverse physiological processes in schistosomes. Among others two Abl tyrosine kinases, SmAbl1 and SmAbl2, were identified in Schistosoma mansoni and shown to be transcribed in the gonads and the gastrodermis. SmAbl1 activity was blocked by Imatinib, a known Abl-TK inhibitor used in human cancer therapy (Gleevec/Glivec). Imatinib exhibited dramatic effects on the morphology and physiology of adult schistosomes in vitro causing the death of the parasites. Methodology/Principal Findings Here we show modeling data supporting the targeting of SmAbl1/2 by Imatinib. A biochemical assay confirmed that SmAbl2 activity is also inhibited by Imatinib. Microarray analyses and qRT-PCR experiments were done to unravel transcriptional processes influenced by Imatinib in adult schistosomes in vitro demonstrating a wide influence on worm physiology. Surface-, muscle-, gut and gonad-associated processes were affected as evidenced by the differential transcription of e.g. the gynecophoral canal protein gene GCP, paramyosin, titin, hemoglobinase, and cathepsins. Furthermore, transcript levels of VAL-7 and egg formation-associated genes such as tyrosinase 1, p14, and fs800-like were affected as well as those of signaling genes including a ribosomal protein S6 kinase and a glutamate receptor. Finally, a comparative in silico analysis of the obtained microarray data sets and previous data analyzing the effect of a TGFβR1 inhibitor on transcription provided first evidence for an association of TGFβ and Abl kinase signaling. Among others GCP and egg formation-associated genes were identified as common targets. Conclusions/Significance

  8. 76 FR 65559 - Culturally Significant Objects Imported for Exhibition Determinations: “Mummy: Secrets of the Tomb”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Mummy: Secrets of the Tomb'' SUMMARY... objects to be included in the exhibition ``Mummy: Secrets of the Tomb'' imported from abroad for...

  9. 77 FR 31421 - Culturally Significant Objects Imported for Exhibition Determinations: “Portrait of Helena de Kay”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Portrait of Helena de Kay'' SUMMARY... object to be included in the exhibition ``Portrait of Helena de Kay,'' imported from abroad for...

  10. 78 FR 144 - Culturally Significant Objects Imported for Exhibition-Determinations: “Girl With a Pearl Earring...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition-- Determinations: ``Girl With a Pearl Earring: Dutch... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Girl with...

  11. 75 FR 53730 - Culturally Significant Object Imported for Exhibition Determinations: “The Roman Mosaic from Lod...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ... Culturally Significant Object Imported for Exhibition Determinations: ``The Roman Mosaic from Lod, Israel... of August 28, 2000, I hereby determine that the object to be included in the exhibition ``The Roman... of Art, New York, New York, from on or about September 28, 2010, until on or about April 3, 2011,...

  12. 76 FR 45646 - Culturally Significant Objects Imported for Exhibition Determinations: “5,000 Years of Chinese...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``5,000 Years of Chinese Jade..., 2003), I hereby determine that the objects to be included in the exhibition ``5,000 Years of...

  13. 78 FR 77771 - Culturally Significant Object Imported for Exhibition Determinations: “Love and Play: A Pair of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Love and Play: A Pair of Paintings by..., I hereby determine that the object to be included in the exhibition ``Love and Play: A Pair...

  14. 78 FR 4585 - Culturally Significant Objects Imported for Exhibition Determinations: “Albrecht Dürer: Master...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Albrecht D rer: Master Drawings... Delegation of Authority No. 236-3 of August 28, 2000 (and, as appropriate, Delegation of Authority No. 257 of April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Albrecht D...

  15. 76 FR 63702 - Culturally Significant Objects Imported for Exhibition Determinations: “Aphrodite and the Gods of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Aphrodite and the Gods of Love... determine that the objects to be included in the exhibition ``Aphrodite and the Gods of Love,''...

  16. 76 FR 30751 - Culturally Significant Object Imported for Exhibition Determinations: “Turkish Taste at the Court...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Turkish Taste at the Court of Marie... ``Turkish Taste at the Court of Marie- Antoinette,'' imported from abroad for temporary exhibition...

  17. 77 FR 57637 - Culturally Significant Objects Imported for Exhibition Determinations: “City of Gold: Tomb and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``City of Gold: Tomb and Temple in... ``City of Gold: Tomb and Temple in Ancient Cyprus,'' imported from abroad for temporary exhibition...

  18. 77 FR 64373 - Culturally Significant Object Imported for Exhibition Determinations: “Erotic Gold: The Art and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Erotic Gold: The Art and Life of... April 15, 2003), I hereby determine that the object to be included in the exhibition ``Erotic Gold:...

  19. 77 FR 2341 - Culturally Significant Objects Imported for Exhibition Determinations: “The Cult of Beauty: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Cult of Beauty: The Victorian... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``The Cult...

  20. 77 FR 52783 - Culturally Significant Objects Imported for Exhibition Determinations: “Rudolf Nureyev: A Life in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Rudolf Nureyev: A Life in Dance... determine that the objects to be included in the exhibition ``Rudolf Nureyev: A Life in Dance''...

  1. 76 FR 73759 - Culturally Significant Objects Imported for Exhibition Determinations: “Ancient Egypt-Art and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Ancient Egypt--Art and Magic: Treasures From the Foundation Gandur pour L'Art, Geneva, Switzerland'' SUMMARY: Notice is hereby given of... included in the exhibition ``Ancient Egypt--Art and Magic: Treasures from the Foundation Gandur pour...

  2. 76 FR 39974 - Culturally Significant Object Imported for Exhibition Determinations: “Titian's Woman in a Blue...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Titian's Woman in a Blue Dress `La... ``Titian's Woman in a Blue Dress `La Bella','' imported from abroad for temporary exhibition within...

  3. 75 FR 82128 - Culturally Significant Objects Imported for Exhibition Determinations: “Gifts of the Sultan: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Gifts of the Sultan: The Arts of... the exhibition ``Gifts of the Sultan: The Arts of Giving at the Islamic Courts'' imported from...

  4. 78 FR 50137 - Culturally Significant Objects Imported for Exhibition Determination: “Heaven and Earth: Art of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... Culturally Significant Objects Imported for Exhibition Determination: ``Heaven and Earth: Art of Byzantium... determinations made by the Department of State pertaining to the exhibition ``Heaven and Earth: Art of Byzantium... ``Heaven and Earth: Art of Byzantium from Greek Collections,'' at the Art Institute of Chicago,...

  5. 75 FR 13805 - Culturally Significant Objects Imported for Exhibition Determinations: “Race to the End of the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Race to the End of the Earth... that the objects to be included in the exhibition ``Race to the End of the Earth,'' imported...

  6. 76 FR 6650 - Culturally Significant Objects Imported for Exhibition Determinations: “Splendors of Faith/Scars...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Splendors of Faith/Scars of Conquest... exhibition ``Splendors of Faith/Scars of Conquest: The Arts of the Missions of Northern New Spain,...

  7. 75 FR 19668 - Culturally Significant Objects Imported for Exhibition Determinations: “From Xanadu to Dadu: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``From Xanadu to Dadu: The World of... hereby determine that the objects to be included in the exhibition ``From Xanadu to Dadu: The World...

  8. 76 FR 56492 - Culturally Significant Objects Imported for Exhibition Determinations: “Antico: The Golden Age of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Antico: The Golden Age of..., 2003), I hereby determine that the objects to be included in the exhibition ``Antico: The Golden Age of... Public Notice of these Determinations be published in the Federal Register. For Further...

  9. 75 FR 57102 - Culturally Significant Objects Imported for Exhibition Determinations: “Titian and the Golden Age...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Titian and the Golden Age of... hereby determine that the objects to be included in the exhibition ``Titian and the Golden Age of... published in the Federal Register. FOR FURTHER INFORMATION CONTACT: For further information, including...

  10. 76 FR 51458 - Culturally Significant Objects Imported for Exhibition Determinations: “Wonder of the Age: Master...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-18

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Wonder of the Age: Master Painters... Age: Master Painters of India, 1100-1900,'' imported from abroad for temporary exhibition within the... in the Federal Register. FOR FURTHER INFORMATION CONTACT: For further information, including a...

  11. 78 FR 58378 - Culturally Significant Objects Imported for Exhibition Determinations: “Peru: Kingdoms of the Sun...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Peru: Kingdoms of the Sun and the..., 2003), I hereby determine that the objects to be included in the exhibition ``Peru: Kingdoms of the...

  12. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... human environment. Therefore, the preparation of an environmental impact statement is not necessary. I... 7 Agriculture 13 2011-01-01 2009-01-01 true Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary...

  13. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... human environment. Therefore, the preparation of an environmental impact statement is not necessary. I... 7 Agriculture 13 2012-01-01 2012-01-01 false Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary...

  14. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... human environment. Therefore, the preparation of an environmental impact statement is not necessary. I... 7 Agriculture 13 2013-01-01 2013-01-01 false Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary...

  15. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary Environmental... attached environmental assessment has been completed for the subject proposal by the FmHA or its...

  16. [Surgical significance of intestinal non-rotation in adults].

    PubMed

    von Flüe, M; Herzog, U; Vogt, B; Tondelli, P; Harder, F

    1991-06-15

    Intestinal non-rotation has been recognized as a cause of obstruction in neonates and children. It is very rarely seen in the adult and assumes surgical significance owing to the potential risk of midgut or ileocecal volvulus. However, it can also cause significant intermittent abdominal pain in the adult. We describe six personally observed patients with this malformation and analyze 38 case reports published in the English and German literature since 1923. We establish that in the acute symptomatic form only emergency laparotomy can provide the correct diagnosis and decrease the risk of bowel disturbance. In the chronic forms, barium studies of the whole intestinal tract reveal varying degrees of midgut malrotation and the non-rotation is confirmed in each case. Also in these forms, exploratory laparotomy with a consequent staging of the abdominal situs is to be recommended. In the operation described by Ladd the ascending colon is sutured at the colon descendens and sigmoideum. After this procedure the mesenterial pedicle is fixed and the risk of midgut torsion remains minimal. All reported cases after surgery are symptom-free. PMID:1857952

  17. 78 FR 38430 - Culturally Significant Objects Imported for Exhibition; Determinations: “Of Heaven and Earth: 500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition; Determinations: ``Of Heaven and Earth: 500 Years of... Earth: 500 Years of Italian Painting from Glasgow Museums,'' imported from abroad for...

  18. 77 FR 59701 - Culturally Significant Objects Imported for Exhibition Determinations: “Florence at the Dawn of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Florence at the Dawn of Renaissance... at the Dawn of Renaissance: Painting and Illumination,'' imported from abroad for...

  19. Imaging assessment and clinical significance of pneumatosis in adult patients.

    PubMed

    Lassandro, Francesco; Valente, Tullio; Rea, Gaetano; Lassandro, Giulia; Golia, Erica; Brunese, Luca; Laghi, Andrea

    2015-01-01

    Gas detection in the bowel wall and in portomesenteric venous vessels in adults has long been related to intestinal infarction and poor outcome; many case reports have shown that pneumatosis may be associated with a large variety of pathological situations, ranging from absolutely benign and asymptomatic forms to abdominal catastrophes. Several studies have been conducted on this topic with different conclusions, probably due to differences in population so that the clinical value of these signs is still questioned. Intestinal pneumatosis, especially if presenting with a band-like pattern and if associated with portomesenteric vein gas, when observed in an acute abdominal setting should raise the suspicion of mesenteric infarct and prompt a careful search for other signs of intestinal involvement, so as not to miss cases of life-threatening intestinal infarct or allow them to further evolve into extensive necrosis with worse prognosis. In this review we illustrate the most relevant aspects of these debated but significant radiological signs. PMID:25297049

  20. DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs

    PubMed Central

    Cheng, Liang; Jiang, Yue; Wang, Zhenzhen; Shi, Hongbo; Sun, Jie; Yang, Haixiu; Zhang, Shuo; Hu, Yang; Zhou, Meng

    2016-01-01

    The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing corresponding TCs. Currently, DisSim implemented five state-of-the-art methods to measure the similarity between Disease Ontology (DO) terms and provide the significance of the similarity score. Furthermore, DisSim integrated TCs of diseases from the Comparative Toxicogenomics Database (CTD), which can help to identify potential relationships between TCs and similar diseases. The system can be accessed from http://123.59.132.21:8080/DisSim. PMID:27457921

  1. DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs.

    PubMed

    Cheng, Liang; Jiang, Yue; Wang, Zhenzhen; Shi, Hongbo; Sun, Jie; Yang, Haixiu; Zhang, Shuo; Hu, Yang; Zhou, Meng

    2016-01-01

    The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing corresponding TCs. Currently, DisSim implemented five state-of-the-art methods to measure the similarity between Disease Ontology (DO) terms and provide the significance of the similarity score. Furthermore, DisSim integrated TCs of diseases from the Comparative Toxicogenomics Database (CTD), which can help to identify potential relationships between TCs and similar diseases. The system can be accessed from http://123.59.132.21:8080/DisSim. PMID:27457921

  2. Adolescent, but not adult, rats exhibit ethanol-mediated appetitive second-order conditioning

    PubMed Central

    Pautassi, Ricardo Marcos; Myers, Mallory; Spear, Linda Patia; Molina, Juan Carlos; Spear, Norman E.

    2008-01-01

    Background Adolescent rats are less sensitive to the sedative effects of ethanol than older animals. They also seem to perceive the reinforcing properties of ethanol. However, unlike neonates or infants, ethanol-mediated appetitive behavior has yet to be clearly shown in adolescents. Appetitive ethanol reinforcement was assessed in adolescent (postnatal day 33, P33) and adult rats (P71) through second-order conditioning (SOC). Methods On P32 or P70 animals were intragastrically administered ethanol (0.5 or 2.0 g/kg) paired with intraoral pulses of sucrose (CS1, first-order conditioning phase). CS1 delivery took place either 5-20 (Early pairing) or 30-45 (Late pairing) min following ethanol. CS1 exposure and ethanol administration were separated by 240 min in unpaired controls. On P33 or P71, animals were presented the CS1 (second-order conditioning phase) while in a distinctive chamber (CS2). Then, they were tested for CS2 preference. Results Early and late paired adolescents, but not adults, had greater preference for the CS2 than controls, a result indicative of ontogenetic variation in ethanol-mediated reinforcement. During the CS1 - CS2 associative phase, paired adolescents given 2.0 g/kg ethanol wall-climbed more than controls. Blood and brain ethanol levels associated with the 0.5 and 2.0 g/kg doses at the onset of each conditioning phase did not differ substantially across age, with mean BECs of 38 and 112 mg %. Conclusions These data indicate age-related differences between adolescent and adult rats in terms of sensitivity to ethanol’s motivational effects. Adolescents exhibit high sensitivity for ethanol’s appetitive effects. These animals also showed EtOH-mediated behavioral activation during the second-order conditioning phase. The SOC preparation provides a valuable conditioning model for assessing ethanol’s motivational effects across ontogeny. PMID:18782343

  3. 75 FR 82129 - Culturally Significant Objects Imported for Exhibition Determinations: “Francis Alÿs: A Story of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Francis Al s: A Story of Deception'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority vested in me...

  4. 69 FR 8512 - Culturally Significant Objects Imported for Exhibition; Determinations: “Coming of Age in Ancient...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2004-02-24

    ....), Delegation of Authority No. 234 of October 1, 1999 (64 FR 56014), Delegation of Authority No. 236 of October 19, 1999 (64 FR 57920), as amended, and Delegation of Authority No. 257 of April 15, 2003 (68 FR... Culturally Significant Objects Imported for Exhibition; Determinations: ``Coming of Age in Ancient...

  5. Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk.

    PubMed

    McNamara, Robert K; Jandacek, Ronald; Rider, Therese; Tso, Patrick; Dwivedi, Yogesh; Pandey, Ghanshyam N

    2013-01-01

    Deficiency in long-chain omega-3 (LCn - 3) fatty acids, eicosapentaenoic acid (EPA, 20:5n - 3) and docosahexaenoic acid (DHA, 22:6n - 3), has been implicated in the pathoetiology of cardiovascular disease, a primary cause of excess premature mortality in patients with schizophrenia (SZ). In the present study, we determined erythrocyte EPA + DHA levels in adult medication-free patients SZ (n = 20) and age-matched healthy controls (n = 24). Erythrocyte EPA + DHA composition exhibited by SZ patients (3.5%) was significantly lower than healthy controls (4.5%, -22%, P = 0.007). The majority of SZ patients (72%) exhibited EPA+DHA levels ≤4.0% compared with 37% of controls (Chi-square, P = 0.001). In contrast, the omega-6 fatty acid arachidonic acid (AA, 20:4n - 6) (+9%, P = 0.02) and the AA:EPA + DHA ratio (+28%, P = 0.0004) were significantly greater in SZ patients. Linoleic acid (18:2n - 6) was significantly lower (-12%, P = 0.009) and the erythrocyte 20:3/18:2 ratio (an index of delta6-desaturase activity) was significantly elevated in SZ patients. Compared with same-gender controls, EPA + DHA composition was significantly lower in male (-19%, P = 0.04) but not female (-13%, P = 0.33) SZ patients, whereas the 20:3/18:2 ratio was significantly elevated in both male (+22%, P = 0.008) and female (+22%, P = 0.04) SZ patients. These results suggest that the majority of SZ patients exhibit low LCn - 3 fatty acid levels which may place them at increased risk for cardiovascular morbidity and mortality. PMID:23533712

  6. Significant and Unintended Consequences: The GI Bill and Adult Education.

    ERIC Educational Resources Information Center

    Rose, Amy D.

    1994-01-01

    The GI Bill and armed services education programs during and following World War II provided a laboratory for adult education services that have since been initiated on campuses nationwide. These include counseling and career centers, program acceleration, and credit for experiential learning for the largely nontraditional veteran student…

  7. The Significance of the Work-Place for Adult Education.

    ERIC Educational Resources Information Center

    Mackie, Karl

    1983-01-01

    Recognition of the importance of the workplace derives from the pervasive influence of work on adult development, the substantial scale of education and training carried out at work, changes in the nature of work and occupations, and new forms and content in worker education. (SK)

  8. Diet Selection Exhibited by Juvenile and Adult Lifestages of the Omnivores Western Tarnished Plant Bug, Lygus hesperus and Tarnished Plant Bug, Lygus lineolaris

    PubMed Central

    Hagler, James R.; Jackson, C. Glen; Blackmer, Jacquelyn L.

    2010-01-01

    Lygus hesperus Knight and Lygus lineolaris (Palisot de Beauvois) (Heteroptera: Miridae) are economically important plant bugs on many crops worldwide. However, these omnivores are also facultative predators on a wide variety of insects. This study was conducted to quantify and compare herbivory and carnivory exhibited among different lifestages of these two insect pests. The feeding activity of a total of 422 individuals was observed for 1 h each in feeding arenas containing a cotton leaf disk and copious amounts of the sweetpotato whitefly, Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) eggs, nymphs and adults. The L. hesperus and L. lineolaris lifestages examined included adults and 3rd, 4th and 5th instar nymphs. Plant feeding occupied the majority of both species' time budget, regardless of the species or lifestage examined. There was a tendency for L. lineolaris lifestages to feed more often and for longer duration on plant tissue than L. hesperus. All lifestages of both species rarely fed on B. tabaci, but when they did, they preferred nymphs > adults > eggs. There were only a few cases where there were significant differences in predation rates and prey handling times exhibited among lifestages and between species, but juvenile L. hesperus tended to be more predaceous than juvenile L. lineolaris on whitefly nymphs and adults and 5thinstar and adult L. lineolaris were significantly more herbaceous than their L. hesperus counterparts. In addition, the younger individuals of both species tended to have greater prey handling times than their older counterparts. The significance of these findings is discussed. PMID:20879921

  9. Startle response memory and hippocampal changes in adult zebrafish pharmacologically-induced to exhibit anxiety/depression-like behaviors.

    PubMed

    Pittman, Julian T; Lott, Chad S

    2014-01-17

    Zebrafish (Danio rerio) are rapidly becoming a popular animal model for neurobehavioral and psychopharmacological research. While startle testing is a well-established assay to investigate anxiety-like behaviors in different species, screening of the startle response and its habituation in zebrafish is a new direction of translational biomedical research. This study focuses on a novel behavioral protocol to assess a tapping-induced startle response and its habituation in adult zebrafish that have been pharmacologically-induced to exhibit anxiety/depression-like behaviors. We demonstrated that zebrafish exhibit robust learning performance in a task adapted from the mammalian literature, a modified plus maze, and showed that ethanol and fluoxetine impair memory performance in this maze when administered after training at a dose that does not impair motor function, however, leads to significant upregulation of hippocampal serotoninergic neurons. These results suggest that the maze associative learning paradigm has face and construct validity and that zebrafish may become a translationally relevant study species for the analysis of the mechanisms of learning and memory changes associated with psychopharmacological treatment of anxiety/depression. PMID:24184510

  10. 78 FR 16565 - Culturally Significant Objects Imported for Exhibition Determinations: “Le Corbusier: An Atlas of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... Landscapes'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... Modern Landscapes,'' imported from abroad for temporary exhibition within the United States, are...

  11. Tumorigenic lung tumorospheres exhibit stem-like features with significantly increased expression of CD133 and ABCG2.

    PubMed

    Zhao, Wensi; Luo, Yi; Li, Boyi; Zhang, Tao

    2016-09-01

    Accumulating evidence supports the existence of cancer stem cells (CSCs) in human tumors, and the successful certification of CSCs may lead to the identification of therapeutic targets, which are more effective for the treatment of cancer. The use of spherical cancer models has increased in popularity in cancer stem cell investigations. Tumorospheres, which are used as a model of CSCs and are established in serum‑free medium supplemented with growth factors under non‑adherent conditions, are one of the most commonly used cancer spherical models and are a valuable method for enriching the CSC fraction. To investigate whether this model is applicable in lung cancer (LC), the identification of lung CSCs and their capacities is essential. In the present study, lung CSCs were enriched by sphere-forming culturing and their stem‑like properties were assessed. The results indicated that the lung tumorospheres had enhanced proliferation, clonality, invasion and cisplatin‑resistance, and showed significantly increased expression levels of CD133 and breast cancer resistance protein (ABCG2). These results, together with findings previously reported in literature, indicated that the sphere‑forming culturing of LC cells induced the enrichment of CSCs and that the tumorospheres exhibited stem cell characteristics. In addition, the higher expression levels of CD133 and ABCG2 in the tumorospheres may provide a rationale for therapeutic targets for LC. PMID:27432082

  12. Tumorigenic lung tumorospheres exhibit stem-like features with significantly increased expression of CD133 and ABCG2

    PubMed Central

    Zhao, Wensi; Luo, Yi; Li, Boyi; Zhang, Tao

    2016-01-01

    Accumulating evidence supports the existence of cancer stem cells (CSCs) in human tumors, and the successful certification of CSCs may lead to the identification of therapeutic targets, which are more effective for the treatment of cancer. The use of spherical cancer models has increased in popularity in cancer stem cell investigations. Tumorospheres, which are used as a model of CSCs and are established in serum-free medium supplemented with growth factors under non-adherent conditions, are one of the most commonly used cancer spherical models and are a valuable method for enriching the CSC fraction. To investigate whether this model is applicable in lung cancer (LC), the identification of lung CSCs and their capacities is essential. In the present study, lung CSCs were enriched by sphere-forming culturing and their stem-like properties were assessed. The results indicated that the lung tumorospheres had enhanced proliferation, clonality, invasion and cisplatin-resistance, and showed significantly increased expression levels of CD133 and breast cancer resistance protein (ABCG2). These results, together with findings previously reported in literature, indicated that the sphere-forming culturing of LC cells induced the enrichment of CSCs and that the tumorospheres exhibited stem cell characteristics. In addition, the higher expression levels of CD133 and ABCG2 in the tumorospheres may provide a rationale for therapeutic targets for LC. PMID:27432082

  13. On the significance of adult play: what does social play tell us about adult horse welfare?

    NASA Astrophysics Data System (ADS)

    Hausberger, Martine; Fureix, Carole; Bourjade, Marie; Wessel-Robert, Sabine; Richard-Yris, Marie-Annick

    2012-04-01

    Play remains a mystery and adult play even more so. More typical of young stages in healthy individuals, it occurs rarely at adult stages but then more often in captive/domestic animals, which can imply spatial, social and/or feeding deprivations or restrictions that are challenging to welfare, than in animals living in natural conditions. Here, we tested the hypothesis that adult play may reflect altered welfare states and chronic stress in horses, in which, as in several species, play rarely occurs at adult stages in natural conditions. We observed the behaviour (in particular, social play) of riding school horses during occasional outings in a paddock and measured several stress indicators when these horses were in their individual home boxes. Our results revealed that (1) the number of horses and rates of adult play appeared very high compared to field report data and (2) most stress indicators measured differed between `players' and `non-players', revealing that most `playful' animals were suffering from more chronic stress than `non-playful' horses. Frequency of play behaviour correlated with a score of chronic stress. This first discovery of a relationship between adult play and altered welfare opens new lines of research that certainly deserves comparative studies in a variety of species.

  14. Thalamocortical Projections onto Behaviorally Relevant Neurons Exhibit Plasticity during Adult Motor Learning.

    PubMed

    Biane, Jeremy S; Takashima, Yoshio; Scanziani, Massimo; Conner, James M; Tuszynski, Mark H

    2016-03-16

    Layer 5 neurons of the neocortex receive direct and relatively strong input from the thalamus. However, the intralaminar distribution of these inputs and their capacity for plasticity in adult animals are largely unknown. In slices of the primary motor cortex (M1), we simultaneously recorded from pairs of corticospinal neurons associated with control of distinct motor outputs: distal forelimb versus proximal forelimb. Activation of ChR2-expressing thalamocortical afferents in M1 before motor learning produced equivalent responses in monosynaptic excitation of neurons controlling the distal and proximal forelimb, suggesting balanced thalamic input at baseline. Following skilled grasp training, however, thalamocortical input shifted to bias activation of corticospinal neurons associated with control of the distal forelimb. This increase was associated with a cell-specific increase in mEPSC amplitude but not presynaptic release probability. These findings demonstrate distinct and highly segregated plasticity of thalamocortical projections during adult learning. PMID:26948893

  15. The fetal/neonatal mouse liver exhibits transcriptional features of the adult pancreas.

    EPA Science Inventory

    Metabolic homeostasis of the organism is maintained by the liver’s ability to detoxify and eliminate xenobiotics through the expression of xenobiotic metabolism enxymes (XME). The fetus and neonate have been hypothesized to exhibit increased sensitivity to xenobiotic toxicity. T...

  16. 75 FR 28095 - Culturally Significant Object Imported for Exhibition Determinations: “E Ku Ana Ka Paia...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ..., Responsibility and the Ku Images'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to...: Unification, Responsibility and the Ku Images,'' imported from abroad for temporary exhibition within...

  17. 75 FR 38589 - Culturally Significant Objects Imported for Exhibition Determinations: “The Origins of Writing in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-02

    ... Ancient Middle East'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... Ancient Middle East,'' imported from abroad for temporary exhibition within the United States, are...

  18. 77 FR 43644 - Culturally Significant Objects Imported for Exhibition Determinations: “Byzantine Art in the Mary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... Michael Jaharis Galleries of Greek, Roman and Byzantine Art'' SUMMARY: Notice is hereby given of the... exhibition ``Byzantine Art in the Mary and Michael Jaharis Galleries of Greek, Roman and Byzantine...

  19. 75 FR 53013 - Culturally Significant Objects Imported for Exhibition Determinations: “The Pre-Raphaelite Lens...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... Photography and Painting, 1848-1875'' SUMMARY: Notice is hereby given of the following determinations... the exhibition ``The Pre-Raphaelite Lens: British Photography and Painting, 1848-1875,'' imported...

  20. Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue.

    PubMed

    Simbulan, R K; Liu, X; Feuer, S K; Maltepe, E; Donjacour, A; Rinaudo, P

    2016-02-01

    Prenatal development is highly plastic and readily influenced by the environment. Adverse conditions have been shown to alter organ development and predispose offspring to chronic diseases, including diabetes and hypertension. Notably, it appears that the changes in glucocorticoid hormones or glucocorticoid receptor (GR) levels in peripheral tissues could play a role in the development of chronic diseases. We have previously demonstrated that in vitro fertilization (IVF) and preimplantation embryo culture is associated with growth alterations and glucose intolerance in mice. However, it is unknown if GR signaling is affected in adult IVF offspring. Here we show that GR expression is increased in inbred (C57Bl6/J) and outbred (CF-1× B6D2F1/J) blastocysts following in vitro culture and elevated levels are also present in the adipose tissue of adult male mice. Importantly, genes involved in lipolysis and triglyceride synthesis and responsive to GR were also increased in adipose tissue, indicating that increased GR activates downstream gene pathways. The promoter region of GR, previously reported to be epigenetically modified by perinatal manipulation, showed no changes in DNA methylation status. Our findings demonstrate that IVF results in a long-term change in GR gene expression in a sex- and tissue-specific manner. These changes in adipose tissues may well contribute to the metabolic phenotype in mice conceived by IVF. PMID:26511158

  1. 78 FR 56767 - Culturally Significant Objects Imported for Exhibition Determinations: “Cercle et Carré and the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... Spirit of Abstract Art'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... International Spirit of Abstract Art,'' imported from abroad for temporary exhibition within the United States... Georgia Museum of Art, Athens, Georgia, from on or about October 12, 2013, until on or about January...

  2. 75 FR 27383 - Culturally Significant Objects Imported for Exhibition Determinations: “A Gift From the Desert...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-14

    ..., History and Culture of the Arabian Horse'' SUMMARY: Notice is hereby given of the following determinations... Desert: The Art, History and Culture of the Arabian Horse,'' imported from abroad for temporary... exhibit objects at the International Museum of the Horse, from on or about May 29, 2010, until on or...

  3. EEC- and ADULT-associated TP63 mutations exhibit functional heterogeneity toward P63 responsive sequences.

    PubMed

    Monti, Paola; Russo, Debora; Bocciardi, Renata; Foggetti, Giorgia; Menichini, Paola; Divizia, Maria T; Lerone, Margherita; Graziano, Claudio; Wischmeijer, Anita; Viadiu, Hector; Ravazzolo, Roberto; Inga, Alberto; Fronza, Gilberto

    2013-06-01

    TP63 germ-line mutations are responsible for a group of human ectodermal dysplasia syndromes, underlining the key role of P63 in the development of ectoderm-derived tissues. Here, we report the identification of two TP63 alleles, G134V (p.Gly173Val) and insR155 (p.Thr193_Tyr194insArg), associated to ADULT and EEC syndromes, respectively. These alleles, along with previously identified G134D (p.Gly173Asp) and R204W (p.Arg243Trp), were functionally characterized in yeast, studied in a mammalian cell line and modeled based on the crystal structure of the P63 DNA-binding domain. Although the p.Arg243Trp mutant showed both complete loss of transactivation function and ability to interfere over wild-type P63, the impact of p.Gly173Asp, p.Gly173Val, and p.Thr193_Tyr194insArg varied depending on the response element (RE) tested. Interestingly, p.Gly173Asp and p.Gly173Val mutants were characterized by a severe defect in transactivation along with interfering ability on two DN-P63α-specific REs derived from genes closely related to the clinical manifestations of the TP63-associated syndromes, namely PERP and COL18A1. The modeling of the mutations supported the distinct functional effect of each mutant. The present results highlight the importance of integrating different functional endpoints that take in account the features of P63 proteins' target sequences to examine the impact of TP63 mutations and the associated clinical variability. PMID:23463580

  4. 77 FR 319 - Culturally Significant Objects Imported for Exhibition Determinations: “Put Your Freedom in the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-04

    ..., Love, & Politics in the 1980s'' from on or about February 11, 2012, until on or about June 3, 2012, and... within the United States, is of cultural significance. The object is imported pursuant to a...

  5. Human Adult Retinal Pigment Epithelial Stem Cell–Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue

    PubMed Central

    Blenkinsop, Timothy A.; Saini, Janmeet S.; Maminishkis, Arvydas; Bharti, Kapil; Wan, Qin; Banzon, Tina; Lotfi, Mostafa; Davis, Janine; Singh, Deepti; Rizzolo, Lawrence J.; Miller, Sheldon; Temple, Sally; Stern, Jeffrey H.

    2015-01-01

    Purpose We tested what native features have been preserved with a new culture protocol for adult human RPE. Methods We cultured RPE from adult human eyes. Standard protocols for immunohistochemistry, electron microscopy, electrophysiology, fluid transport, and ELISA were used. Results Confluent monolayers of adult human RPE cultures exhibit characteristics of native RPE. Immunohistochemistry demonstrated polarized expression of RPE markers. Electron microscopy illustrated characteristics of native RPE. The mean transepithelial potential (TEP) was 1.19 ± 0.24 mV (mean ± SEM, n = 31), apical positive, and the mean transepithelial resistance (RT) was 178.7 ± 9.9 Ω·cm2 (mean ± SEM, n = 31). Application of 100 μM adenosine triphosphate (ATP) apically increased net fluid absorption (Jv) by 6.11 ± 0.53 μL·cm2·h−1 (mean ± SEM, n = 6) and TEP by 0.33 ± 0.048 mV (mean ± SEM, n = 25). Gene expression of cultured RPE was comparable to native adult RPE (n = 5); however, native RPE RNA was harvested between 24 and 40 hours after death and, therefore, may not accurately reflect healthy native RPE. Vascular endothelial growth factor secreted preferentially basally 2582 ± 146 pg/mL/d, compared to an apical secretion of 1548 ± 162 pg/mL/d (n = 14, P < 0.01), while PEDF preferentially secreted apically 1487 ± 280 ng/mL/d compared to a basolateral secretion of 864 ± 132 ng/mL/d (n = 14, P < 0.01). Conclusions The new culture model preserves native RPE morphology, electrophysiology, and gene and protein expression patterns, and may be a useful model to study RPE physiology, disease, and transplantation. PMID:26540654

  6. Natural FCoV infection: cats with FIP exhibit significantly higher viral loads than healthy infected cats.

    PubMed

    Kipar, Anja; Baptiste, Keith; Barth, Andreas; Reinacher, Manfred

    2006-02-01

    Natural feline coronavirus (FCoV) infection has been shown to not only induce intestinal infection with viral shedding, but also systemic infection which either remains without clinical signs or leads to feline infectious peritonitis (FIP). As systemic infection is not the key event in the development of FIP, the question arises as to whether a potential difference in viral load might be of importance. Therefore, the purpose of this study was to quantitatively assess feline coronavirus (FCoV) RNA loads in haemolymphatic tissues of healthy, long-term FCoV-infected cats and cats with FIP. In cats that died from FIP, viral loads were significantly higher, indicating a higher rate of viral replication or a reduced capacity for viral clearance in cats developing and/or suffering from FIP. PMID:16213766

  7. Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by Plasmodium.

    PubMed

    Marques, Joana; Vilanova, Eduardo; Mourão, Paulo A S; Fernàndez-Busquets, Xavier

    2016-01-01

    The antimalarial activity of heparin, against which there are no resistances known, has not been therapeutically exploited due to its potent anticoagulating activity. Here, we have explored the antiplasmodial capacity of heparin-like sulfated polysaccharides from the sea cucumbers Ludwigothurea grisea and Isostichopus badionotus, from the red alga Botryocladia occidentalis, and from the marine sponge Desmapsamma anchorata. In vitro experiments demonstrated for most compounds significant inhibition of Plasmodium falciparum growth at low-anticoagulant concentrations. This activity was found to operate through inhibition of erythrocyte invasion by Plasmodium, likely mediated by a coating of the parasite similar to that observed for heparin. In vivo four-day suppressive tests showed that several of the sulfated polysaccharides improved the survival of Plasmodium yoelii-infected mice. In one animal treated with I. badionotus fucan parasitemia was reduced from 10.4% to undetectable levels, and Western blot analysis revealed the presence of antibodies against P. yoelii antigens in its plasma. The retarded invasion mediated by sulfated polysaccharides, and the ensuing prolonged exposure of Plasmodium to the immune system, can be explored for the design of new therapeutic approaches against malaria where heparin-related polysaccharides of low anticoagulating activity could play a dual role as drugs and as potentiators of immune responses. PMID:27071342

  8. Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by Plasmodium

    PubMed Central

    Marques, Joana; Vilanova, Eduardo; Mourão, Paulo A. S.; Fernàndez-Busquets, Xavier

    2016-01-01

    The antimalarial activity of heparin, against which there are no resistances known, has not been therapeutically exploited due to its potent anticoagulating activity. Here, we have explored the antiplasmodial capacity of heparin-like sulfated polysaccharides from the sea cucumbers Ludwigothurea grisea and Isostichopus badionotus, from the red alga Botryocladia occidentalis, and from the marine sponge Desmapsamma anchorata. In vitro experiments demonstrated for most compounds significant inhibition of Plasmodium falciparum growth at low-anticoagulant concentrations. This activity was found to operate through inhibition of erythrocyte invasion by Plasmodium, likely mediated by a coating of the parasite similar to that observed for heparin. In vivo four-day suppressive tests showed that several of the sulfated polysaccharides improved the survival of Plasmodium yoelii-infected mice. In one animal treated with I. badionotus fucan parasitemia was reduced from 10.4% to undetectable levels, and Western blot analysis revealed the presence of antibodies against P. yoelii antigens in its plasma. The retarded invasion mediated by sulfated polysaccharides, and the ensuing prolonged exposure of Plasmodium to the immune system, can be explored for the design of new therapeutic approaches against malaria where heparin-related polysaccharides of low anticoagulating activity could play a dual role as drugs and as potentiators of immune responses. PMID:27071342

  9. The Significance of a Part-Time Degree Course for Adults

    ERIC Educational Resources Information Center

    Styler, W. E.

    1975-01-01

    The significance of the part-time degree course in psychology at the University of Hull under the administration of an adult education department satisfies a need as envisaged by the Russell Report, for more part-time degrees other than those offered by the Open University. (BP)

  10. The Developmental Significance of Late Adolescent Substance Use for Early Adult Functioning

    ERIC Educational Resources Information Center

    Englund, Michelle M.; Siebenbruner, Jessica; Oliva, Elizabeth M.; Egeland, Byron; Chung, Chu-Ting; Long, Jeffrey D.

    2013-01-01

    This study examines the predictive significance of late adolescent substance use groups (i.e., abstainers, experimental users, at-risk users, and abusers) for early adult adaptation. Participants (N = 159) were drawn from a prospective longitudinal study of first-born children of low-income mothers. At 17.5 years of age, participants were assigned…

  11. Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma in Older Adults.

    PubMed

    Guerard, Emily J; Tuchman, Sascha A

    2016-02-01

    Multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) are plasma cell disorders of aging. The landscape of the diagnosis and management of MM and MGUS are rapidly changing. This article provides an updated understanding of the clinical presentation, evaluation, diagnosis, and management of older adults with MM and MGUS. Because most oncology providers are not formally trained in geriatric medicine, geriatricians play a key role in providing oncologists with a broader understanding of patient health status in the hope of improving outcomes for older adults with MM. PMID:26614868

  12. Appendicular fractures: a significant problem among institutionalized adults with developmental disabilities.

    PubMed

    Ryder, K M; Williams, J; Womack, C; Nayak, N G; Nasef, S; Bush, A; Tylavsky, F A; Carbone, L

    2003-09-01

    A high incidence of nontraumatic fracture in adults with developmental disabilities living in a state-run facility was described. Risk factors for fracture, including bone mineral density (BMD), were investigated to determine whether people at highest risk for fracture could be prospectively identified. There was a 7.3% incidence of fracture among 391 adults. Risk factors were examined for 23 residents with fracture and 23 age-, race-, and gender-matched controls. There was a trend for antiepileptic medication usage to be associated with fractures. Estimated BMD by heel ultrasound did not predict fracture; however, values were much lower than those for the general population. Fractures and low BMD are significant problems among institutionalized adults with severe developmental disabilities. Further studies to identify therapies to prevent fractures are warranted. PMID:12901709

  13. Symptomatic Chiari malformation in adults: a new classification based on magnetic resonance imaging with clinical and prognostic significance.

    PubMed

    Pillay, P K; Awad, I A; Little, J R; Hahn, J F

    1991-05-01

    Thirty-five consecutive adults with Chiari malformation and progressive symptoms underwent surgical treatment at a single institution over a 3-year period. All patients underwent magnetic resonance imaging scan before and after surgery. Images of the craniovertebral junction confirmed tonsillar herniation in all cases and allowed the definition of two anatomically distinct categories of the Chiari malformation in this age group. Twenty of the 35 patients had concomitant syringomyelia and were classified as Type A. The remaining 15 patients had evidence of frank herniation of the brain stem below the foramen magnum without evidence of syringomyelia and were labeled Type B. Type A patients had a predominant central cord symptomatology; Type B patients exhibited signs and symptoms of brain stem or cerebellar compression. The principal surgical procedure consisted of decompression of the foramen magnum, opening of the fourth ventricular outlet, and plugging of the obex. Significant improvement in preoperative symptoms and signs was observed in 9 of the 20 patients (45%) with syringomyelia (Type A), as compared to 13 of the 15 patients (87%) without syringomyelia (Type B). Postoperative reduction in syrinx volume was observed in 11 of the 20 patients with syringomyelia, including all 9 patients with excellent results. Magnetic resonance imaging has allowed a classification of the adult Chiari malformation in adults based on objective anatomic criteria, with clinical and prognostic relevance. The presence of syringomyelia implies a less favorable response to surgical intervention. PMID:1876240

  14. [Expression of PRAME gene in adult acute leukemia and its significance in prognosis].

    PubMed

    Zhou, Pei-Yi; Li, Wei-Jia; Wei, Cai-Xia; Zhou, Zhi

    2007-12-01

    The study was aimed to investigate the expression of preferentially expressed antigen of melanoma (PRAME) gene in adult acute leukemia and its clinical significance. The expression of the PRAME gene of bone marrow was measured by reverse transcriptase polymerase chain reaction (RT-PCR) in 73 adult newly diagnosed acute leukemia patients, 3 relapsed patients, 7 patients with idiopathic thrombocytopenic purpura (ITP) and 8 healthy donors, as well as two AL cell-lines (K562 and U937). The results indicated that PRAME mRNA was expressed in 42.9% AML patients (n=24) and 20% ALL patients (n=4), also in two leukemia cell-lines K562 and U937, but not in eight health donors and seven ITP patients. PRAME expression not correlated to the white blood count, hemoglobin level, platelet count and the percentage of blasts at diagnosis, yet independent of age, sex, and FAB type. PRAME mRNA expression in complete remission group seems much higher than those in partial complete remission group and death group. The increased levels of expression could be found prior to the relapse in one patient being regularly monitored. PRAME gene was overexpressed in adult acute leukemia patients and leukemia cell-lines. It is concluded that the expression of PRAME is an indicator of favorable prognosis and can be a useful tool for monitoring minimal residual disease (MRD) in adult acute leukemia. Differential expression between adult acute leukemia patients and healthy volunteers suggests that the immunogenic antigens PRAME are potential candidates for immunotherapy in adult acute leukemia. PMID:18088461

  15. The developmental significance of late adolescent substance use for early adult functioning.

    PubMed

    Englund, Michelle M; Siebenbruner, Jessica; Oliva, Elizabeth M; Egeland, Byron; Chung, Chu-Ting; Long, Jeffrey D

    2013-08-01

    This study examines the predictive significance of late adolescent substance use groups (i.e., abstainers, experimental users, at-risk users, and abusers) for early adult adaptation. Participants (N = 159) were drawn from a prospective longitudinal study of first-born children of low-income mothers. At 17.5 years of age, participants were assigned to substance use groups on the basis of their level of substance use involvement. At 26 years, early adult competence was assessed in the areas of education, work, romantic relationships, and global adaptation. Results indicate that 17.5-year substance use group membership significantly predicted high school completion, regular involvement in a long-term romantic relationship, good or better work ethic, and good or better global adjustment at 26 years when controlling for gender; IQ; 16-year internalizing and externalizing behavior problems, parental monitoring, and peer competence; and current substance use at 26 years. Group comparisons indicate that late adolescent substance use experimenters were significantly more likely in early adulthood to have (a) a high school diploma or higher level of education compared with abstainers (OR = 8.83); (b) regular involvement in long-term romantic relationships (OR = 3.23), and good or better global adaptation (OR = 4.08) compared with at-risk users; and (c) good or better work ethic (OR = 4.04) compared with abusers. This research indicates that patterns of late adolescent substance use has implications for early adult functioning in salient developmental domains. PMID:23025264

  16. Murine mesenchymal stem cells transplanted to the central nervous system of neonatal versus adult mice exhibit distinct engraftment kinetics and express receptors that guide neuronal cell migration.

    PubMed

    Phinney, Donald G; Baddoo, Melody; Dutreil, Maria; Gaupp, Dina; Lai, Wen Tzu; Isakova, Iryna A

    2006-06-01

    Mesenchymal stem cells (MSCs) have demonstrated efficacy as cellular vectors for treating a variety of nervous system disorders. Nevertheless, few studies have quantified MSC engraftment levels or explored the mechanisms that promote their survival and migration in nervous tissue. In this study, we compared the engraftment kinetics and anatomical distribution of murine, male MSCs injected intracranially into neonatal versus adult female mice using a real-time PCR assay that targets the mouse SRY gene. These analyses revealed that MSCs exhibited low but equivalent engraftment levels in the central nervous system (CNS) of neonatal and adult transplant recipients at 12 days post-injection. However, MSC engraftment levels were significantly greater at 60 and 150 days post-transplantation in neonates as compared to adults. Despite these differences, engrafted MSCs were widely distributed along the neuraxis of the CNS in both transplant groups. Collectively, these data indicate that proliferation, but not engraftment and migration, of MSCs in brain are regulated by the host microenvironment. Using a genomics approach, we also identified MSC subpopulations that express neural adhesion proteins and receptors that regulate neuronal cell migration in brain, including cadherin 2, neurexin 1, ninjurin 1, neogenin 1, neuropilin 2, and roundabout homolog 1 and 4. Functional studies indicate these proteins confer cell adhesion and migration of MSCs in response to the appropriate chemoattractant. On the basis of these findings, we conclude that the unique molecular composition of MSC subpopulations imparts to them an inherent capacity to engraft and migrate in brain. These subpopulations may represent more potent cellular vectors for treating CNS disorders. PMID:16846379

  17. Clinical significance of brain white matter hyperintensities in young adults with psychiatric illness.

    PubMed

    Breeze, Janis L; Hesdorffer, Dale C; Hong, Xiaoni; Frazier, Jean A; Renshaw, Perry F

    2003-01-01

    Magnetic resonance imaging (MRI) provides detailed images of brain anatomy, with especially clear definition of gray and white matter structures. Several brain MRI studies have suggested that adults with bipolar disorder (BD) are more likely to have "white matter hyperintensities" (WMH) than adults without BD. The disproportionately greater frequency of these lesions in otherwise physically healthy patients suggests that the illness itself, or treatments used to control the illness, may be risk factors for the development of white matter changes. Similarly, WMH may be an etiological factor for some types of BD. In addition to reviewing the relevant literature, this research study attempted to determine whether lithium treatment is associated with an increased prevalence of WMH in young adults with psychiatric illness. To test this hypothesis, we evaluated over 600 brain MRI scans from inpatients at McLean Hospital, Belmont, Massachusetts. We controlled for possible confounding variables such as age, vascular disease, substance abuse, and markers of illness severity. We found that individuals with BD were no more likely to have WMH than other psychiatric patients. Lithium use was nonsignificantly associated with the presence of WMH. A multivariate regression model for the presence of WMH showed that heart disease, female gender, and multiple psychiatric admissions were significant predictors of WMH. This study does not support previous findings that BD, compared to other psychiatric illnesses, was associated with increased risk of WMH. Lithium use may be subtly associated with WMH. Our results are consistent with previous research that found an association between cardiovascular disease, advanced age, and the presence of WMH, though our analysis appears to be unique in its inclusion of cardiovascular disease as a risk factor in young adults with psychiatric illness. PMID:14555427

  18. Factors of Significant Impact on Proficiency Levels of Adult ESL Learners within Post-Secondary Education in Puerto Rico

    ERIC Educational Resources Information Center

    Perez, Ramon

    2011-01-01

    This qualitative case study seeks to identify factors that have a significant impact on the second language proficiency levels of adult English as a Second Language (ESL) learners at a four-year university in Puerto Rico. Current data indicate that a significant percentage of adult ESL learners encounter major difficulties within the process of…

  19. Identifying Adult Dengue Patients at Low Risk for Clinically Significant Bleeding

    PubMed Central

    Wong, Joshua G. X.; Thein, Tun Linn; Leo, Yee-Sin; Pang, Junxiong; Lye, David C.

    2016-01-01

    Background Clinically significant bleeding is important for subsequent optimal case management in dengue patients, but most studies have focused on dengue severity as an outcome. Our study objective was to identify differences in admission parameters between patients who developed clinically significant bleeding and those that did not. We sought to develop a model for discriminating between these patients. Methods We conducted a retrospective study of 4,383 adults aged >18 years who were hospitalized with dengue infection at Tan Tock Seng Hospital, Singapore from 2005 to 2008. Patients were divided into those with clinically significant bleeding (n = 188), and those without (n = 4,195). Demographic, clinical, and laboratory variables on admission were compared between groups to determine factors associated with clinically significant bleeding during hospitalization. Results On admission, female gender (p<0.001); temperature >38°C (p<0.001); nausea/vomiting (p = 0.009) and abdominal pain/tenderness (p = 0.005); lower systolic blood pressure (p<0.001); higher pulse rate (p<0.001); increased absolute neutrophil count (ANC; p<0.001); reduced absolute lymphocyte count (ALC; p<0.001), haematocrit percentage (p<0.001) and platelet count (p = 0.04), and increased prothrombin time (p = 0.003) were significantly associated with clinically significant bleeding on univariate analysis. Multivariate analysis showed that independent variables in the final model were female gender (aOR 2.85; 95% CI: 1.9–4.33); temperature >38°C (aOR 1.81; 95% CI: 1.27–2.61), nausea/vomiting (aOR 1.39; 95% CI: 0.94–2.12), ANC (aOR 1.3; 95% CI: 1.15–1.46), ALC (aOR 0.4; 95% CI: 0.25–0.64), hematocrit percentage (aOR 0.96; 95% CI: 0.92–1.002) and platelet count (aOR 0.993; 95% CI: 0.988–0.998). At the cutoff of -3.919, the model achieved an AUC of 0.758 (sensitivity:0.87, specificity: 0.38, PPV: 0.06, NPV: 0.98). Conclusion Clinical risk factors associated with clinically significant

  20. Early repolarization is associated with significant coronary artery stenosis in asymptomatic adults.

    PubMed

    Suh, Beomseok; Park, Sehhoon; Shin, Dong Wook; Ahn, Hongkeun; Cho, Seongcheol; Lee, Seung-Pyo; Park, Eun-Ah; Lee, Hyejin; Park, Jin Ho; Cho, BeLong

    2016-02-01

    The aim of our study was to investigate the relationship between early repolarization (ERP) and coronary heart disease (CHD) by evaluating its association with coronary artery stenosis and plaques. Consecutive asymptomatic adults aged 30 or more without CHD were investigated (n = 3100). Adjusting for major cardiovascular risk factors, ERP was significantly associated with significant coronary stenosis with incremental predictive value (aOR 1.71, 95% CI 1.13-2.60; ROC AUC 0.763 vs. 0.723, P < 0.001; NRI 4.86%, P = 0.042; IDI 0.0030, P = 0.040), specifically in intermediate risk group (aOR 2.33, 95% CI 1.29-4.20; ROC AUC 0.753 vs. 0.708, P = 0.001). ERP was shown to be especially associated with significant coronary stenosis with non-calcified plaque (aOR 2.26, 95% CI 1.28-3.98). Our study is the first to directly show the association of ERP with CHD. Future studies are needed to replicate our results and investigate whether it would be beneficial to include ERP in risk algorithms for CHD screening. PMID:26694693

  1. Three-dimensional scaffolds of fetal decellularized hearts exhibit enhanced potential to support cardiac cells in comparison to the adult.

    PubMed

    Silva, A C; Rodrigues, S C; Caldeira, J; Nunes, A M; Sampaio-Pinto, V; Resende, T P; Oliveira, M J; Barbosa, M A; Thorsteinsdóttir, S; Nascimento, D S; Pinto-do-Ó, P

    2016-10-01

    A main challenge in cardiac tissue engineering is the limited data on microenvironmental cues that sustain survival, proliferation and functional proficiency of cardiac cells. The aim of our study was to evaluate the potential of fetal (E18) and adult myocardial extracellular matrix (ECM) to support cardiac cells. Acellular three-dimensional (3D) bioscaffolds were obtained by parallel decellularization of fetal- and adult-heart explants thereby ensuring reliable comparison. Acellular scaffolds retained main constituents of the cardiac ECM including distinctive biochemical and structural meshwork features of the native equivalents. In vitro, fetal and adult ECM-matrices supported 3D culture of heart-derived Sca-1(+) progenitors and of neonatal cardiomyocytes, which migrated toward the center of the scaffold and displayed elongated morphology and excellent viability. At the culture end-point, more Sca-1(+) cells and cardiomyocytes were found adhered and inside fetal bioscaffolds, compared to the adult. Higher repopulation yields of Sca-1(+) cells on fetal ECM relied on β1-integrin independent mitogenic signals. Sca-1(+) cells on fetal bioscaffolds showed a gene expression profile that anticipates the synthesis of a permissive microenvironment for cardiomyogenesis. Our findings demonstrate the superior potential of the 3D fetal microenvironment to support and instruct cardiac cells. This knowledge should be integrated in the design of next-generation biomimetic materials for heart repair. PMID:27424216

  2. Dietary Mannoheptulose Does Not Significantly Alter Daily Energy Expenditure in Adult Labrador Retrievers.

    PubMed

    McKnight, Leslie L; Root-McCaig, Jared; Wright, David; Davenport, Gary M; France, James; Shoveller, Anna Kate

    2015-01-01

    Mannoheptulose (MH), a sugar found in avocados that inhibits glycolysis in vitro, has been preliminarily investigated as a novel food ingredient for dogs. This study aimed to determine the effects of dietary MH, delivered as an extract of un-ripened avocado, on energy expenditure (EE) in healthy adult Labrador Retriever dogs (total of 12 dogs, 26.99 ± 0.634 kg, 4.9 ± 0.2 y). The study was a double-blind, cross-over with each dog receiving both dietary treatments, control (CON) and MH (400 mg/kg of diet; 6 mg/kg BW), in random order. Resting and post-prandial (10 h) EE and respiratory quotient (RQ) were determined by indirect calorimetry (d 42). The following day, body composition was assessed using dual X-ray absorptiometry. Continuous activity monitoring was conducted using an Atical® accelerometer (d 43-47). A vastus lateralis muscle biopsy was obtained prior to the morning meal (d 49) and 4 h after consumption of their meal (d 56) to determine the protein content and phosphorylation of 5' adenosine monophosphate-activated protein kinase (AMPK). Diet did not affect body weight, resting EE or skeletal muscle AMPK phosphorylation. Dogs fed MH had significantly lower post-prandial RQ (p = 0.02) and ratio of fat to lean body mass (p = 0.02). Physical activity during light time periods (but not dark) was lower in dogs fed MH (p < 0.05) during weekends, but not on weekdays. These results suggest that MH affects energy balance of adult dogs, but that these effects are not dose dependent and not due to physical activity. PMID:26656105

  3. Dietary Mannoheptulose Does Not Significantly Alter Daily Energy Expenditure in Adult Labrador Retrievers

    PubMed Central

    McKnight, Leslie L.; Root-McCaig, Jared; Wright, David; Davenport, Gary M.; France, James; Shoveller, Anna Kate

    2015-01-01

    Mannoheptulose (MH), a sugar found in avocados that inhibits glycolysis in vitro, has been preliminarily investigated as a novel food ingredient for dogs. This study aimed to determine the effects of dietary MH, delivered as an extract of un-ripened avocado, on energy expenditure (EE) in healthy adult Labrador Retriever dogs (total of 12 dogs, 26.99 ± 0.634 kg, 4.9 ± 0.2 y). The study was a double-blind, cross-over with each dog receiving both dietary treatments, control (CON) and MH (400 mg/kg of diet; 6 mg/kg BW), in random order. Resting and post-prandial (10 h) EE and respiratory quotient (RQ) were determined by indirect calorimetry (d 42). The following day, body composition was assessed using dual X-ray absorptiometry. Continuous activity monitoring was conducted using an Atical® accelerometer (d 43–47). A vastus lateralis muscle biopsy was obtained prior to the morning meal (d 49) and 4 h after consumption of their meal (d 56) to determine the protein content and phosphorylation of 5' adenosine monophosphate-activated protein kinase (AMPK). Diet did not affect body weight, resting EE or skeletal muscle AMPK phosphorylation. Dogs fed MH had significantly lower post-prandial RQ (p = 0.02) and ratio of fat to lean body mass (p = 0.02). Physical activity during light time periods (but not dark) was lower in dogs fed MH (p < 0.05) during weekends, but not on weekdays. These results suggest that MH affects energy balance of adult dogs, but that these effects are not dose dependent and not due to physical activity. PMID:26656105

  4. Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi

    PubMed Central

    Strizzi, Luigi; Margaryan, Naira V.; Gerami, Pedram; Haghighat, Zahra; Harms, Paul W.; Madonna, Gabriele; Botti, Gerardo; Ascierto, Paolo A.; Hendrix, Mary J.C.

    2016-01-01

    The TGF-β associated growth factor Nodal is highly expressed in aggressive metastatic melanoma. Determining the risk for melanomagenesis from Nodal expression in nevi prior to the development of melanoma may be useful for both the screening and prevention of melanoma. Tissue sections of human adult nevi with or without a history of melanoma were stained by immunohistochemistry (IHC) for Nodal, the Nodal co-receptor Cripto-1, and Notch4, which have previously been shown to be associated with Nodal expression in melanoma. The degree of Nodal, Cripto-1 and Notch4 staining was scored and correlated with available clinical data. Median IHC scores for Nodal, Cripto-1 and Notch4 expression were significantly higher in nevi removed from patients who eventually developed melanoma compared with nevi from patients with no history of melanoma. In addition, the degree of Nodal expression in nevi from patients who eventually developed melanoma correlated significantly with the Breslow depth of the melanoma. Expression of Nodal and components of its signaling pathway in nevi may represent a biomarker for selecting a unique subset of patients requiring increased surveillance for screening and prevention of melanoma.

  5. Appendicular Fractures: A Significant Problem among Institutionalized Adults with Developmental Disabilities.

    ERIC Educational Resources Information Center

    Ryder, K. M.; Williams, J.; Womack, C.; Nayak, N. G.; Nasef, S.; Bush, A.; Tylavsky, F. A.; Carbone, L.

    2003-01-01

    This study found a high incidence of nontraumatic fractures in adults with developmental disabilities living in a state-run facility, a 7.3% incidence among 391 adults. Factors associated with fractures included use of antiepileptic medication. Although bone mineral density (BMD) by heel ultrasound did not predict fracture, values were much lower…

  6. No Significant Effect of Prefrontal tDCS on Working Memory Performance in Older Adults

    PubMed Central

    Nilsson, Jonna; Lebedev, Alexander V.; Lövdén, Martin

    2015-01-01

    Transcranial direct current stimulation (tDCS) has been put forward as a non-pharmacological alternative for alleviating cognitive decline in old age. Although results have shown some promise, little is known about the optimal stimulation parameters for modulation in the cognitive domain. In this study, the effects of tDCS over the dorsolateral prefrontal cortex (dlPFC) on working memory performance were investigated in thirty older adults. An N-back task assessed working memory before, during and after anodal tDCS at a current strength of 1 mA and 2 mA, in addition to sham stimulation. The study used a single-blind, cross-over design. The results revealed no significant effect of tDCS on accuracy or response times during or after stimulation, for any of the current strengths. These results suggest that a single session of tDCS over the dlPFC is unlikely to improve working memory, as assessed by an N-back task, in old age. PMID:26696882

  7. High Frequency of Clinically Significant Bacteremia in Adults Hospitalized With Falciparum Malaria.

    PubMed

    Nyein, Phyo Pyae; Aung, Ne Myo; Kyi, Tint Tint; Htet, Zaw Win; Anstey, Nicholas M; Kyi, Mar Mar; Hanson, Josh

    2016-01-01

    Background.  African children with severe falciparum malaria commonly have concomitant Gram-negative bacteremia, but co-infection has been thought to be relatively rare in adult malaria. Methods.  Adults with a diagnosis of falciparum malaria hospitalized at 4 tertiary referral hospitals in Myanmar had blood cultures collected at admission. The frequency of concomitant bacteremia and the clinical characteristics of the patients, with and without bacteremia, were explored. Results.  Of 67 adults hospitalized with falciparum malaria, 9 (13% [95% confidence interval, 5.3%-21.6%]) were also bacteremic on admission, 7 (78%) with Gram-negative enteric organisms (Escherichia coli [n = 3], typhoidal Salmonella species [n = 3], nontyphoidal Salmonella [n = 1]). Bacteremic adults had more severe disease (median Respiratory Coma Acidosis Malaria [RCAM] score 3; interquartile range [IQR], 1-4) than those without bacteremia (median RCAM score 1; IQR, 1-2) and had a higher frequency of acute kidney injury (50% vs 16%, P = .03). Although 35 (52%) were at high risk of death (RCAM score ≥2), all 67 patients in the study survived, 51 (76%) of whom received empirical antibiotics on admission. Conclusions.  Bacteremia was relatively frequent in adults hospitalized with falciparum malaria in Myanmar. Like children in high transmission settings, bacteremic adults in this low transmission setting were sicker than nonbacteremic adults, and were often difficult to identify at presentation. Empirical antibiotics may also be appropriate in adults hospitalized with falciparum malaria in low transmission settings, until bacterial infection is excluded. PMID:26989752

  8. High Frequency of Clinically Significant Bacteremia in Adults Hospitalized With Falciparum Malaria

    PubMed Central

    Nyein, Phyo Pyae; Aung, Ne Myo; Kyi, Tint Tint; Htet, Zaw Win; Anstey, Nicholas M.; Kyi, Mar Mar; Hanson, Josh

    2016-01-01

    Background. African children with severe falciparum malaria commonly have concomitant Gram-negative bacteremia, but co-infection has been thought to be relatively rare in adult malaria. Methods. Adults with a diagnosis of falciparum malaria hospitalized at 4 tertiary referral hospitals in Myanmar had blood cultures collected at admission. The frequency of concomitant bacteremia and the clinical characteristics of the patients, with and without bacteremia, were explored. Results. Of 67 adults hospitalized with falciparum malaria, 9 (13% [95% confidence interval, 5.3%–21.6%]) were also bacteremic on admission, 7 (78%) with Gram-negative enteric organisms (Escherichia coli [n = 3], typhoidal Salmonella species [n = 3], nontyphoidal Salmonella [n = 1]). Bacteremic adults had more severe disease (median Respiratory Coma Acidosis Malaria [RCAM] score 3; interquartile range [IQR], 1–4) than those without bacteremia (median RCAM score 1; IQR, 1–2) and had a higher frequency of acute kidney injury (50% vs 16%, P = .03). Although 35 (52%) were at high risk of death (RCAM score ≥2), all 67 patients in the study survived, 51 (76%) of whom received empirical antibiotics on admission. Conclusions. Bacteremia was relatively frequent in adults hospitalized with falciparum malaria in Myanmar. Like children in high transmission settings, bacteremic adults in this low transmission setting were sicker than nonbacteremic adults, and were often difficult to identify at presentation. Empirical antibiotics may also be appropriate in adults hospitalized with falciparum malaria in low transmission settings, until bacterial infection is excluded. PMID:26989752

  9. Expiratory-modulated laryngeal motoneurons exhibit a hyperpolarization preceding depolarization during superior laryngeal nerve stimulation in the in vivo adult rat.

    PubMed

    Bautista, Tara G; Sun, Qi-Jian; Pilowsky, Paul M

    2012-03-22

    Swallowing requires the sequential activation of tongue, pharyngeal and esophageal muscles to propel the food bolus towards the stomach. Aspiration during swallow is prevented by adduction of the vocal cords during the oropharyngeal phase. Expiratory-modulated laryngeal motoneurons (ELM) exhibit a burst of action potentials during swallows elicited by electrical stimulation of the superior laryngeal nerve (SLN). Here we sought to investigate changes in membrane potential in ELM during superior laryngeal nerve stimulation in the anaesthetised, in vivo adult rat preparation. Intracellular recordings of ELM in the caudal nucleus ambiguus (identified by antidromic activation from the recurrent laryngeal nerve) demonstrated that ELM bursting activity following SLN stimulation is associated with a depolarization that is preceded by a small hyperpolarization. During spontaneous ELM bursts, the preceding hyperpolarization separated the bursting activity from its usual post-inspiratory activity. These findings demonstrate that the in vivo adult rat preparation is suitable for the study of swallow-related activity in laryngeal motoneurons. PMID:22326041

  10. Children's Drawings of Significant Figures for a Peer or an Adult Audience

    ERIC Educational Resources Information Center

    Burkitt, Esther; Watling, Dawn; Murray, Lucy

    2011-01-01

    The present study assessed if children would present different information in their drawings of emotion eliciting stimuli when they believed that an adult or a child audience would view their drawings. Seventy-five 6-year-olds (44 boys and 31 girls) were allocated to three groups: the reference group, the child audience group and the adult…

  11. Drosophila mutants of the autism candidate gene neurobeachin (rugose) exhibit neuro-developmental disorders, aberrant synaptic properties, altered locomotion, impaired adult social behavior and activity patterns

    PubMed Central

    Wise, Alexandra; Tenezaca, Luis; Fernandez, Robert W.; Schatoff, Emma; Flores, Julian; Ueda, Atsushi; Zhong, Xiaotian; Wu, Chun-Fang; Simon, Anne F.; Venkatesh, Tadmiri

    2016-01-01

    Autism spectrum disorder (ASD) is a neurodevelopmental disorder in humans characterized by complex behavioral deficits, including intellectual disability, impaired social interactions and hyperactivity. ASD exhibits a strong genetic component with underlying multi-gene interactions. Candidate gene studies have shown that the neurobeachin gene is disrupted in human patients with idiopathic autism (Castermans et al., 2003). The gene for neurobeachin (NBEA) spans the common fragile site FRA 13A and encodes a signal scaffold protein (Savelyeva et al., 2006). In mice, NBEA has been shown to be involved in the trafficking and function of a specific subset of synaptic vesicles. (Medrihan et al., 2009; Savelyeva, Sagulenko, Schmitt, & Schwab, 2006). rugose (rg) is the Drosophila homologue of the mammalian and human neurobeachin. Our previous genetic and molecular analyses have shown that rg encodes an A kinase anchor protein (DAKAP 550), which interacts with components of the EGFR and Notch mediated signaling pathways, facilitating cross-talk between these and other pathways (Shamloula et al., 2002). We now present functional data from studies on the larval neuromuscular junction that reveal abnormal synaptic architecture and physiology. In addition, adult rg loss-of-function mutants exhibit defective social interactions, impaired habituation, aberrant locomotion and hyperactivity. These results demonstrate that Drosophila neurobeachin (rugose) mutants exhibit phenotypic characteristics reminiscent of human ASD and thus could serve as a genetic model for studying autism spectrum disorders. PMID:26100104

  12. Moderate drinking? Alcohol consumption significantly decreases neurogenesis in the adult hippocampus.

    PubMed

    Anderson, M L; Nokia, M S; Govindaraju, K P; Shors, T J

    2012-11-01

    Drinking alcohol in moderation is often considered a health-conscious behavior, associated with improved cardiovascular and brain health. However, "moderate" amounts of alcohol include drinking 3-4 alcohol beverages in a day, which is closer to binge drinking and may do more harm than good. Here we examined how daily drinking of moderate-high alcohol alters the production of new neurons in the adult hippocampus. Male and female adult Sprague-Dawley rats were provided free access to a liquid replacement diet that was supplemented with either 4% ethanol or Maltodextrin for a period of 2 weeks. Proliferating cells were labeled with 5-bromo-2-deoxyuridine (BrdU) and the number of BrdU-positive cells in the hippocampus was assessed after the final day of drinking. A subset of rats was also exposed to a motor skill or associative learning task to examine the functional effects of alcohol consumption. The drinking regime resulted in an average blood alcohol concentration of approximately 0.08%, which is comparable to the human legal driving limit in many countries. This level of intoxication did not impair motor skill learning or function in either sex, nor did the alcohol consumption disrupt associative learning 2 days after drinking. Therefore, moderate alcohol consumption did not disrupt basic sensory, motor or learning processes. However, the number of cells produced in the dentate gyrus of the hippocampus was reduced by nearly 40%. Thus, even moderate consumption of alcohol for a relatively short period of time can have profound effects on structural plasticity in the adult brain. PMID:22906480

  13. Etiologic significance of enlargement of the left atrial appendage in adults

    SciTech Connect

    Green, C.E.; Kelley, M.J.; Higgins, C.B.

    1982-01-01

    Fifty-one patients were divided into two groups: 20 patients with proven rheumatic mitral valve disease (RMVD) and 31 patients with left atrial enlargement (LAE) of a nonrheumatic etiology. The latter group included patients with ischemic papillary muscle dysfunction, mitral valve prolapse, and congestive cardiomyopathy. Radiographic studies showed that enlargement of the left atrial appendage (LAAE) was present in 18 of 20 rheumatics but in only one of 31 nonrheumatics. There was no direct relationship between enlargement of the LAA and radiographic or echocardiographic left atrial size, degree of pulmonary venous hypertension (PVH), or presence of atrial fibrillation. It is postulated that rheumatic influammation of the LAA allows it to dilate out of proportion to the body of the left atrium. In the adult patient with radiographic findings of PVH, LAAE is a valuable and specific radiographic sign of rheumatic mitral valve disease.

  14. Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes.

    PubMed

    Sepúlveda, Maria; Armangue, Thaís; Martinez-Hernandez, Eugenia; Arrambide, Georgina; Sola-Valls, Nuria; Sabater, Lidia; Téllez, Nieves; Midaglia, Luciana; Ariño, Helena; Peschl, Patrick; Reindl, Markus; Rovira, Alex; Montalban, Xavier; Blanco, Yolanda; Dalmau, Josep; Graus, Francesc; Saiz, Albert

    2016-07-01

    The aim of this study was to report the clinical spectrum associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) in adult patients, and to assess whether phenotypic variants are dependent on recognition of rodent MOG epitopes. We retrospectively analyzed the features, course and outcome of 56 patients whose samples were investigated by brain tissue immunohistochemistry and cell-based assays using human and rodent MOG. The median age at symptom onset was 37 years (range 18-70); 35 patients (63 %) were female. After a median follow-up of 43 months (range 4-554), only 14 patients (25 %) developed a neuromyelitis optica spectrum disorder (NMOSD), 27 patients (47 %) retained the initial diagnosis of isolated optic neuritis, 7 (12 %) of longitudinally extensive transverse myelitis, and 2 (4 %) of acute disseminated encephalomyelitis; 6 patients (11 %) developed atypical demyelinating syndromes (4 had relapsing episodes of short myelitis lesions which in one occurred with optic neuritis; 1 had relapsing brainstem symptoms, and 1 relapsing demyelinating encephalomyelitis). The course was frequently associated with relapses (71 %) and good outcome. Twenty-seven patients (49 %) had antibodies that recognized rodent MOG epitopes, and 9 of them (16 %) showed a myelin staining pattern in rodent tissue. Only the myelin staining pattern was linked to NMOSD (p = 0.005). In conclusion, MOG autoimmunity in adult patients associates with a clinical spectrum wider than the one expected for patients with suspected NMOSD and overall good outcome. Antibodies to rodent MOG epitopes do not associate with any phenotypic variant. PMID:27147513

  15. Growth hormone significantly increases the adult height of children with idiopathic short stature: comparison of subgroups and benefit

    PubMed Central

    2014-01-01

    Background Children with Idiopathic Short Stature do not attain a normal adult height. The improvement of adult height with treatment with recombinant human growth hormone (rhGH), at doses of 0.16 to 0.28 mg/kg/week is modest, usually less that 4 cm, and they remain short as adults. The benefit obtained seems dose dependent and benefits of 7.0 to 8.0 cm have been reported with higher doses of 0.32 to 0.4 mg/kg/week, but the number of studies is limited. The topic has remained controversial. Objective The objective was to conduct a retrospective analysis of our experience with 123 children with ISS treated with 0.32 ± 0.03 mg/kg/week of rhGH, with the aim of comparing the different subgroups of non-familial short stature, familial short stature, normal puberty, and delayed puberty and to assess the benefit by comparison with 305 untreated historical controls, from nine different randomized and nonrandomized controlled studies. Results Eighty eight of our children (68 males and 20 females) attained an adult height or near adult height of -0.71 SDS (0.74 SD) (95% CI, -0.87 to -0.55) with a benefit over untreated controls of 9.5 cm (7.4 to 11.6 cm) for males and 8.6 cm (6.7 to 10.5 cm) for females. In the analysis of the subgroups, the adult height and adult height gain of children with non-familial short stature were significantly higher than of familial short stature. No difference was found in the cohorts with normal or delayed puberty in any of the subgroups, except between the non-familial short stature and familial short stature puberty cohorts. This has implications for the interpretation of the benefit of treatment in studies where the number of children with familial short stature in the controls or treated subjects is not known. The treatment was safe. There were no significant adverse events. The IGF-1 values were essentially within the levels expected for the stages of puberty. Conclusion Our experience was quite positive with normalization of

  16. Disease screening of three breeding populations of adult exhibition budgerigars (Melopsittacus undulatus) in New Zealand reveals a high prevalence of a novel polyomavirus and avian malaria infection.

    PubMed

    Baron, Hamish R; Howe, Laryssa; Varsani, Arvind; Doneley, Robert J T

    2014-03-01

    Disease surveillance is vital to the management of New Zealand's endemic and threatened avian species. Three infectious agents that are potential threats to New Zealand's endemic birds include avian polyomavirus (APV), beak and feather disease virus (BFDV), and avian malaria. All three agents have been reported in New Zealand; however, possible reservoir populations have not been identified. In this communication, we report the first study of APV, BFDV, and avian malaria in introduced adult exhibition budgerigars (Melopsittacus undulatus) in New Zealand. Blood samples were collected from 90 living adult budgerigars from three breeding locations in the North Island of New Zealand. An overall APV prevalence of 22% was determined using a broad-spectrum nested PCR that amplified the major capsid protein VP1 gene of polyomavirus. Phylogenetic analysis of the VP1 gene revealed a unique isolate of APV, which had a sequence divergence of 32% to previously reported budgerigar fledgling disease strains and 33% to the recently reported New Zealand finch isolate. All of the budgerigars sampled were found to be PCR negative for BFDV, and an overall prevalence of 30% was detected by PCR for avian malaria. Sequencing revealed the presence of ubiquitous malarial strains and also the potentially destructive Plasmodium relictum strain. The results of this study suggest that both APV and avian malaria are present in New Zealand adult budgerigars, and our study highlights the need for further studies to determine whether these pathogens in captive bird populations may be a threat or spill over into New Zealand's endemic and threatened avifauna and whether prevention and control methods need to be implemented. PMID:24758122

  17. Morphometric study of sacral hiatus in adult human Egyptian sacra: Their significance in caudal epidural anesthesia

    PubMed Central

    Mustafa, Mohamed S.; Mahmoud, Omayma M.; El Raouf, Hoda H. A.; Atef, Hosam M.

    2012-01-01

    Background: The reliability and success of caudal epidural anesthesia depends on anatomic variations of sacral hiatus (SH) as observed by various authors. SH is an important landmark during caudal epidural block (CEB).The purpose of the present study was to clarify the morphometric characteristics of the SH in human Egyptian dry sacra and pelvic radiographs and identification of nearest ony landmarks to permit correct and uncomplicated caudal epidural accesses. Methods: The present study was done on 46 human adult Egyptian dry sacra. The maximum height, midventral curved length, and maximum breadth of each sacrum were measured and sacral and curvature indices were calculated. According to sacral indices, sacra were divided into 2 groups (22 male and 24 female sacra). SH was evaluated in each sacrum according to its shape, level of its apex, and base according to sacral and coccygeal vertebrae, length, anteroposterior (AP) diameter at its apex, and transverse width at its base. Linear distances were measured between the apex of SH and second sacral foramina, right and left superolateral sacral crests. The distance between the 2 superolateral sacral crests also was measured. Results: The most common types of SH were the inverted U and inverted V (in male) and inverted V and dumbbell shaped (in female). Absent SH was observed in male group only. The most common location of SH apex was at the level of S4 in all groups of dry sacra and S3 in all groups of lumbosacral spine radiographs, whereas S5 was the common level of its base. The mean SH length, transverse width of its base, and AP diameter of its apex were 2.1±0.80, 1.7±0.26, and 0.48±0.19 cm. Female sacra showed narrower SH apex than male. The distance between the S2 foramen and the apex of the SH was 4.1±1.14, 3.67±1.21, and 4.48±1.01 cm in total, female and male sacra, respectively. Conclusion: Sacrum and SH showed morphometric variations in adult Egyptians. The equilateral triangle is an important guide

  18. Analysis of the Distribution of Mucins in Adult Human Gastric Mucosa and Its Functional Significance

    PubMed Central

    2016-01-01

    Introduction Mucins are complex composition of carbohydrates seen in the epithelial cells lining the gastrointestinal tract (GIT). Normal distribution of such mucins in different part of the GIT and its alteration in various inflammatory, benign and malignant lesions of GIT has aroused interest in the field of histochemistry. Aim By applying variety of histochemical techniques an attempt has been made to draw a map of mucin secretion by the different epithelial cell types in different parts of the stomach. Materials and Methods Fifty samples were taken each from different parts of the stomach like fundus, body and pylorus, from dissected fresh specimens (total of 150 specimens). Tissue samples were subjected for routine process and studied for histological and different histochemical staining. Results Mucin pattern in adult predominantly secretes neutral mucosubstances. Surface epithelium shows predominant neutral mucin while cardiac and gastric glands with foveolar cells show moderate amount. Sialomucin is present in a few cells of the surface epithelium, foveolar cells and in most of the mucous neck cells. Small amount of sialomucin and sulphomucin are found in surface epithelial foveolar cells while traces of sulphomucin are found in deep foveolar cells. Mucous neck cells secrete both sulphomucin and sialomucin. Conclusion Normal gastric mucosa adjacent to gastric ulcers and malignant tumours of stomach secretes mucins which differ histochemically and biochemically from that of normal. Early recognition of such changes could be useful in recognizing the different type of carcinomas and their prognosis. PMID:27042436

  19. Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes.

    PubMed

    Hightower, Kendra E; Wang, Ruolan; Deanda, Felix; Johns, Brian A; Weaver, Kurt; Shen, Yingnian; Tomberlin, Ginger H; Carter, H Luke; Broderick, Timothy; Sigethy, Scott; Seki, Takahiro; Kobayashi, Masanori; Underwood, Mark R

    2011-10-01

    The integrase inhibitor (INI) dolutegravir (DTG; S/GSK1349572) has significant activity against HIV-1 isolates with raltegravir (RAL)- and elvitegravir (ELV)-associated resistance mutations. As an initial step in characterizing the different resistance profiles of DTG, RAL, and ELV, we determined the dissociation rates of these INIs with integrase (IN)-DNA complexes containing a broad panel of IN proteins, including IN substitutions corresponding to signature RAL and ELV resistance mutations. DTG dissociates slowly from a wild-type IN-DNA complex at 37°C with an off-rate of 2.7 × 10(-6) s(-1) and a dissociative half-life (t(1/2)) of 71 h, significantly longer than the half-lives for RAL (8.8 h) and ELV (2.7 h). Prolonged binding (t(1/2), at least 5 h) was observed for DTG with IN-DNA complexes containing E92, Y143, Q148, and N155 substitutions. The addition of a second substitution to either Q148 or N155 typically resulted in an increase in the off-rate compared to that with the single substitution. For all of the IN substitutions tested, the off-rate of DTG from IN-DNA complexes was significantly slower (from 5 to 40 times slower) than the off-rate of RAL or ELV. These data are consistent with the potential for DTG to have a higher genetic barrier to resistance, provide evidence that the INI off-rate may be an important component of the mechanism of INI resistance, and suggest that the slow dissociation of DTG may contribute to its distinctive resistance profile. PMID:21807982

  20. Adolescents in Institutional Care: Significant Adults, Resilience and Well-Being

    ERIC Educational Resources Information Center

    Mota, Catarina Pinheiro; Matos, Paula Mena

    2015-01-01

    Background: Attachment theory states the importance of secure relationships with significant figures for the development of resilience and well-being. The institutional care context represents a particular environment where relationships beyond the family should be attended for. Objective: The purpose of this study was to analyse the relationship…

  1. Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes

    PubMed Central

    Lucock, Mark; Yates, Zoë; Martin, Charlotte; Choi, Jeong-Hwa; Boyd, Lyndell; Tang, Sa; Naumovski, Nenad; Furst, John; Roach, Paul; Jablonski, Nina; Chaplin, George; Veysey, Martin

    2014-01-01

    Background and objectives: Vitamin D and folate are highly UV sensitive, and critical for maintaining health throughout the lifecycle. This study examines whether solar irradiance during the first trimester of pregnancy influences vitamin D receptor (VDR) and nuclear folate gene variant occurrence, and whether affected genes influence late-life biochemical/clinical phenotypes. Methodology: 228 subjects were examined for periconceptional exposure to solar irradiance, variation in vitamin D/folate genes (polymerase chain reaction (PCR)), dietary intake (food frequency questionnaire (FFQ)) and important adult biochemical/clinical phenotypes. Results: Periconceptional solar irradiance was associated with VDR-BsmI (P = 0.0008wk7), TaqI (P = 0.0014wk7) and EcoRV (P = 0.0030wk6) variant occurrence between post-conceptional weeks 6–8, a period when ossification begins. Similar effects were detected for other VDR gene polymorphisms. Periconceptional solar irradiance was also associated with 19 bp del-DHFR (P = 0.0025wk6), and to a lesser extent C1420T-SHMT (P = 0.0249wk6), a folate-critical time during embryogenesis. These same genes were associated with several late-life phenotypes: VDR-BsmI, TaqI and ApaI determined the relationship between dietary vitamin D and both insulin (P < 0.0001/BB, 0.0007/tt and 0.0173/AA, respectively) and systolic blood pressure (P = 0.0290/Bb, 0.0299/Tt and 0.0412/AA, respectively), making them important early and late in the lifecycle. While these and other phenotype associations were found for the VDR variants, folate polymorphism associations in later-life were limited to C1420T-SHMT (P = 0.0037 and 0.0297 for fasting blood glucose and HbA1c levels, respectively). We additionally report nutrient–gene relationships with body mass index, thiol/folate metabolome, cognition, depression and hypertension. Furthermore, photoperiod at conception influenced occurrence of VDR-Tru9I and 2R3R-TS genotypes (P = 0.0120 and 0.0360, respectively

  2. Pharmacology of Ultrasonic Vocalizations in adult Rats: Significance, Call Classification and Neural Substrate

    PubMed Central

    Brudzynski, Stefan M.

    2015-01-01

    Pharmacological studies of emotional arousal and initiation of emotional states in rats measured by their ultrasonic vocalizations are reviewed. It is postulated that emission of vocalizations is an inseparable feature of emotional states and it evolved from mother-infant interaction. Positive emotional states are associated with emission of 50 kHz vocalizations that could be induced by rewarding situations and dopaminergic activation of the nucleus accumbens and are mediated by D1, D2, and partially D3 dopamine receptors. Three biologically significant subtypes of 50 kHz vocalizations have been identified, all expressing positive emotional states: (1) flat calls without frequency modulation that serve as contact calls during social interactions; (2) frequencymodulated calls without trills that signal rewarding and significantly motivated situation; and (3) frequency-modulated calls with trills or trills themselves that are emitted in highly emotional situations associated with intensive affective state. Negative emotional states are associated with emission of 22 kHz vocalizations that could be induced by aversive situations, muscarinic cholinergic activation of limbic areas of medial diencephalon and forebrain, and are mediated by M2 muscarinic receptors. Two biologically significant subtypes of 22 kHz vocalizations have been identified, both expressing negative emotional sates: (1) long calls that serve as alarm calls and signal external danger; and (2) short calls that express a state of discomfort without external danger. The positive and negative states with emission of vocalizations are initiated by two ascending reticular activating subsystems: the mesolimbic dopaminergic subsystem as a specific positive arousal system, and the mesolimbic cholinergic subsystem as a specific negative arousal system. PMID:26411761

  3. Effects of the short-term learned significance of task-irrelevant sounds on involuntary attention in children and adults.

    PubMed

    Wetzel, Nicole

    2015-10-01

    The present study aimed to test effects of unexpected task-irrelevant environmental sounds, that were short-term learned to be significant, on deviance-related brain activity (event-related potentials; ERPs) and performance in children aged 9-10 years and young adults. Participants performed three conditions. In the first ignore condition an oddball paradigm was presented including two neutral deviant sounds. In the second learning condition significance was attributed to one of the two deviant sounds by defining it as target. In the third condition participants then performed a version of an oddball paradigm, embedded in a narrative, that included the neutral and the now significant but task-irrelevant deviant sound. Results revealed decreased reaction times and hit rates elicited by significant compared to neutral deviant sounds in both age groups whereas P3a, an indicator of orienting of attention and novelty evaluation, was not affected by deviant's learned significance. In contrast, post-deviant processing, reflected by hit rates and ERPs in trials following a significant deviant compared to those following a neutral deviant, was differently modulated in children and adults. Moreover, a clear P3a was observed in the attend condition in both age groups but in the ignore condition in children only. Results indicate that the short-term learned significance of task-irrelevant sounds modulates performance but not orienting and evaluation processes associated with the P3a. Importantly, results demonstrate children's increased susceptibility to task-irrelevant but significant sounds and the ongoing maturation of attention control in the late childhood. PMID:26093029

  4. Clinical Significance and Characterization of Streptococcus tigurinus Isolates in an Adult Population.

    PubMed

    Bourassa, Lori; Clarridge, J E

    2015-11-01

    Streptococcus tigurinus is a newly described member of the Streptococcus mitis group. Due to the difficulty in distinguishing viridans group streptococci (VGS) by phenotype, analysis of 16S rRNA sequences is necessary for the accurate identification of most species. Through a laboratory policy of analyzing all clinically significant isolates from the VGS group by16S rRNA gene sequencing, we identified 14 S. tigurinus isolates from 11 patients. The Vitek 2 system most commonly gave an excellent rating to an incorrect identification (e.g., Streptococcus mitis), as did matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) (e.g., Streptococcus oralis). S. tigurinus strains were recovered from numerous body sites, including the blood, peritoneal fluid, bone, synovial fluid, a perianal abscess, and an arm wound. Retrospective chart review indicated that most isolates were clinically significant, with bacteremia (n = 5), soft tissue infections (n = 3) osteomyelitis (n = 2), infected joint prosthesis (n = 2), and peritonitis (n = 2) being the most common, thus expanding the spectrum of disease associated with S. tigurinus. PMID:26354809

  5. Clinical Significance and Characterization of Streptococcus tigurinus Isolates in an Adult Population

    PubMed Central

    Bourassa, Lori

    2015-01-01

    Streptococcus tigurinus is a newly described member of the Streptococcus mitis group. Due to the difficulty in distinguishing viridans group streptococci (VGS) by phenotype, analysis of 16S rRNA sequences is necessary for the accurate identification of most species. Through a laboratory policy of analyzing all clinically significant isolates from the VGS group by16S rRNA gene sequencing, we identified 14 S. tigurinus isolates from 11 patients. The Vitek 2 system most commonly gave an excellent rating to an incorrect identification (e.g., Streptococcus mitis), as did matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) (e.g., Streptococcus oralis). S. tigurinus strains were recovered from numerous body sites, including the blood, peritoneal fluid, bone, synovial fluid, a perianal abscess, and an arm wound. Retrospective chart review indicated that most isolates were clinically significant, with bacteremia (n = 5), soft tissue infections (n = 3) osteomyelitis (n = 2), infected joint prosthesis (n = 2), and peritonitis (n = 2) being the most common, thus expanding the spectrum of disease associated with S. tigurinus. PMID:26354809

  6. Significance of metabolite extraction method for evaluating sulfamethazine toxicity in adult zebrafish using metabolomics.

    PubMed

    De Sotto, Ryan; Medriano, Carl; Cho, Yunchul; Seok, Kwang-Seol; Park, Youngja; Kim, Sungpyo

    2016-05-01

    Recently, environmental metabolomics has been introduced as a next generation environmental toxicity method which helps in evaluating toxicity of bioactive compounds to non-target organisms. In general, efficient metabolite extraction from target cells is one of the keys to success to better understand the effects of toxic substances to organisms. In this regard, the aim of this study is (1) to compare two sample extraction methods in terms of abundance and quality of metabolites and (2) investigate how this could lead to difference in data interpretation using pathway analysis. For this purpose, the antibiotic sulfamethazine and zebrafish (Danio rerio) were selected as model toxic substance and target organism, respectively. The zebrafish was exposed to four different sulfamethazine concentrations (0, 10, 30, and 50mg/L) for 72h. Metabolites were extracted using two different methods (Bligh and Dyer and solid-phase extraction). A total of 13,538 and 12,469 features were detected using quadrupole time-of-flight liquid chromatography mass spectrometry (QTOF LC-MS). Of these metabolites, 4278 (Bligh and Dyer) and 332 (solid phase extraction) were found to be significant after false discovery rate adjustment at a significance threshold of 0.01. Metlin and KEGG pathway analysis showed comprehensive information from fish samples extracted using Bligh and Dyer compared to solid phase extraction. This study shows that proper selection of sample extraction method is critically important for interpreting and analyzing the toxicity data of organisms when metabolomics is applied. PMID:26827276

  7. Significant Improvements in the Practice Patterns of Adult Related Donor Care in US Transplantation Centers.

    PubMed

    Anthias, Chloe; Shaw, Bronwen E; Kiefer, Deidre M; Liesveld, Jane L; Yared, Jean; Kamble, Rammurti T; D'Souza, Anita; Hematti, Peiman; Seftel, Matthew D; Norkin, Maxim; DeFilipp, Zachariah; Kasow, Kimberly A; Abidi, Muneer H; Savani, Bipin N; Shah, Nirali N; Anderlini, Paolo; Diaz, Miguel A; Malone, Adriana K; Halter, Joerg P; Lazarus, Hillard M; Logan, Brent R; Switzer, Galen E; Pulsipher, Michael A; Confer, Dennis L; O'Donnell, Paul V

    2016-03-01

    Recent investigations have found a higher incidence of adverse events associated with hematopoietic cell donation in related donors (RDs) who have morbidities that if present in an unrelated donor (UD) would preclude donation. In the UD setting, regulatory standards ensure independent assessment of donors, one of several crucial measures to safeguard donor health and safety. A survey conducted by the Center for International Blood and Marrow Transplant Research (CIBMTR) Donor Health and Safety Working Committee in 2007 reported a potential conflict of interest in >70% of US centers, where physicians had simultaneous responsibility for RDs and their recipients. Consequently, several international organizations have endeavored to improve practice through regulations and consensus recommendations. We hypothesized that the changes in the 2012 Foundation for the Accreditation of Cellular Therapy and the Joint Accreditation Committee-International Society for Cellular Therapy and European Society for Blood and Marrow Transplantation standards resulting from the CIBMTR study would have significantly impacted practice. Accordingly, we conducted a follow-up survey of US transplantation centers to assess practice changes since 2007, and to investigate additional areas where RD care was predicted to differ from UD care. A total of 73 centers (53%), performing 79% of RD transplantations in the United States, responded. Significant improvements were observed since the earlier survey; 62% centers now ensure separation of RD and recipient care (P < .0001). This study identifies several areas where RD management does not meet international donor care standards, however. Particular concerns include counseling and assessment of donors before HLA typing, with 61% centers first disclosing donor HLA results to an individual other than the donor, the use of unlicensed mobilization agents, and the absence of long-term donor follow-up. Recommendations for improvement are made. PMID

  8. Adult acclimation to combined temperature and pH stressors significantly enhances reproductive outcomes compared to short-term exposures.

    PubMed

    Suckling, Coleen C; Clark, Melody S; Richard, Joelle; Morley, Simon A; Thorne, Michael A S; Harper, Elizabeth M; Peck, Lloyd S

    2015-05-01

    This study examined the effects of long-term culture under altered conditions on the Antarctic sea urchin, Sterechinus neumayeri. Sterechinus neumayeri was cultured under the combined environmental stressors of lowered pH (-0.3 and -0.5 pH units) and increased temperature (+2 °C) for 2 years. This time-scale covered two full reproductive cycles in this species and analyses included studies on both adult metabolism and larval development. Adults took at least 6-8 months to acclimate to the altered conditions, but beyond this, there was no detectable effect of temperature or pH. Animals were spawned after 6 and 17 months exposure to altered conditions, with markedly different outcomes. At 6 months, the percentage hatching and larval survival rates were greatest in the animals kept at 0 °C under current pH conditions, whilst those under lowered pH and +2 °C performed significantly less well. After 17 months, performance was not significantly different across treatments, including controls. However, under the altered conditions urchins produced larger eggs compared with control animals. These data show that under long-term culture adult S. neumayeri appear to acclimate their metabolic and reproductive physiology to the combined stressors of altered pH and increased temperature, with relatively little measureable effect. They also emphasize the importance of long-term studies in evaluating effects of altered pH, particularly in slow developing marine species with long gonad maturation times, as the effects of altered conditions cannot be accurately evaluated unless gonads have fully matured under the new conditions. PMID:25491898

  9. Methylphenidate significantly improves driving performance of adults with attention-deficit hyperactivity disorder: a randomized crossover trial.

    PubMed

    Verster, Joris C; Bekker, Evelijne M; de Roos, Marlise; Minova, Anita; Eijken, Erik J E; Kooij, J J Sandra; Buitelaar, Jan K; Kenemans, J Leon; Verbaten, Marinus N; Olivier, Berend; Volkerts, Edmund R

    2008-05-01

    Although patients with attention-deficit hyperactivity disorder (ADHD) have reported improved driving performance on methylphenidate, limited evidence exists to support an effect of treatment on driving performance and some regions prohibit driving on methylphenidate. A randomized, crossover trial examining the effects of methylphenidate versus placebo on highway driving in 18 adults with ADHD was carried out. After three days of no treatment, patients received either their usual methylphenidate dose (mean: 14.7 mg; range: 10-30 mg) or placebo and then the opposite treatment after a six to seven days washout period. Patients performed a 100 km driving test during normal traffic, 1.5 h after treatment administration. Standard deviation of lateral position (SDLP), the weaving of the car, was the primary outcome measure. Secondary outcome measurements included the standard deviation of speed and patient reports of driving performance. Driving performance was significantly better in the methylphenidate than in the placebo condition, as reflected by the SDLP difference (2.3 cm, 95% CI = 0.8-3.8, P = 0.004). Variation in speed was similar on treatment and on placebo (-0.05 km/h, 95% CI = -0.4 to 0.2, P = 0.70). Among adults with ADHD, with a history of a positive clinical response to methylphenidate, methylphenidate significantly improves driving performance. PMID:18308788

  10. Outdoor Exhibits

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The National Data Buoy Center (NDBC) at the John C. Stennis Space Center has exhibits located in front of the Visitors Center. These boat-shaped buoys are moored in areas of the ocean that experience hostile environmental conditions. The instruments installed gather information and relay it to the National Weather Service by satellite. Nomad buoys are 20 feet long and weigh 13,900 pounds. They provide information on wind speed and direction, humidity levels, air and sea surface temperature and air pressure. U.S. Coast Guard ships transport buoys to their mooring sites.

  11. Ferrous Sulfate Supplementation Causes Significant Gastrointestinal Side-Effects in Adults: A Systematic Review and Meta-Analysis

    PubMed Central

    Tolkien, Zoe; Stecher, Lynne; Mander, Adrian P.; Pereira, Dora I. A.; Powell, Jonathan J.

    2015-01-01

    Background The tolerability of oral iron supplementation for the treatment of iron deficiency anemia is disputed. Objective Our aim was to quantify the odds of GI side-effects in adults related to current gold standard oral iron therapy, namely ferrous sulfate. Methods Systematic review and meta-analysis of randomized controlled trials (RCTs) evaluating GI side-effects that included ferrous sulfate and a comparator that was either placebo or intravenous (IV) iron. Random effects meta-analysis modelling was undertaken and study heterogeneity was summarised using I2 statistics. Results Forty three trials comprising 6831 adult participants were included. Twenty trials (n = 3168) had a placebo arm and twenty three trials (n = 3663) had an active comparator arm of IV iron. Ferrous sulfate supplementation significantly increased risk of GI side-effects versus placebo with an odds ratio (OR) of 2.32 [95% CI 1.74–3.08, p<0.0001, I2 = 53.6%] and versus IV iron with an OR of 3.05 [95% CI 2.07-4.48, p<0.0001, I2 = 41.6%]. Subgroup analysis in IBD patients showed a similar effect versus IV iron (OR = 3.14, 95% CI 1.34-7.36, p = 0.008, I2 = 0%). Likewise, subgroup analysis of pooled data from 7 RCTs in pregnant women (n = 1028) showed a statistically significant increased risk of GI side-effects for ferrous sulfate although there was marked heterogeneity in the data (OR = 3.33, 95% CI 1.19-9.28, p = 0.02, I2 = 66.1%). Meta-regression did not provide significant evidence of an association between the study OR and the iron dose. Conclusions Our meta-analysis confirms that ferrous sulfate is associated with a significant increase in gastrointestinal-specific side-effects but does not find a relationship with dose. PMID:25700159

  12. Serum Vitamin D Is Significantly Inversely Associated with Disease Severity in Caucasian Adults with Obstructive Sleep Apnea Syndrome

    PubMed Central

    Kerley, Conor P.; Hutchinson, Katrina; Bolger, Kenneth; McGowan, Aisling; Faul, John; Cormican, Liam

    2016-01-01

    Study Objectives: To evaluate vitamin D (25(OH)D) levels in obstructive sleep apnea syndrome (OSAS) and possible relationships to OSAS severity, sleepiness, lung function, nocturnal heart rate (HR), and body composition. We also aimed to compare the 25(OH)D status of a subset of OSAS patients compared to controls matched for important determinants of both OSAS and vitamin D deficiency (VDD). Methods: This was a cross-sectional study conducted at an urban, clinical sleep medicine outpatient center. We recruited newly diagnosed, Caucasian adults who had recently undergone nocturnal polysomnography. We compared body mass index (BMI), body composition (bioelectrical impedance analysis), neck circumference, sleepiness (Epworth Sleepiness Scale), lung function, and vitamin D status (serum 25-hydrpoxyvitamin D (25(OH)D) across OSAS severity categories and non-OSAS subjects. Next, using a case-control design, we compared measures of serum 25(OH)D from OSAS cases to non-OSAS controls who were matched for age, gender, skin pigmentation, sleepiness, season, and BMI. Results: 106 adults (77 male; median age = 54.5; median BMI = 34.3 kg/m2) resident in Dublin, Ireland (latitude 53°N) were recruited and categorized as non-OSAS or mild/moderate/severe OSAS. 98% of OSAS cases had insufficient 25(OH)D (< 75 nmol/L), including 72% with VDD (< 50 nmol/L). 25(OH)D levels decreased with OSAS severity (P = 0.003). 25(OH)D was inversely correlated with BMI, percent body fat, AHI, and nocturnal HR. Subsequent multivariate regression analysis revealed that 25(OH)D was independently associated with both AHI (P = 0.016) and nocturnal HR (P = 0.0419). Our separate case-control study revealed that 25(OH)D was significantly lower in OSAS cases than matched, non-OSAS subjects (P = 0.001). Conclusions: We observed widespread vitamin D deficiency and insufficiency in a Caucasian, OSAS population. There were significant, independent, inverse relationships between 25(OH)D and AHI as well as

  13. Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults

    PubMed Central

    Byakika-Kibwika, Pauline; Lamorde, Mohammed; Okaba-Kayom, Violet; Mayanja-Kizza, Harriet; Katabira, Elly; Hanpithakpong, Warunee; Pakker, Nadine; Dorlo, Thomas P. C.; Tarning, Joel; Lindegardh, Niklas; de Vries, Peter J.; Back, David; Khoo, Saye; Merry, Concepta

    2012-01-01

    Background Treatment of HIV/malaria-coinfected patients with antiretroviral therapy (ART) and artemisinin-based combination therapy has potential for drug interactions. We investigated the pharmacokinetics of artemether, dihydroartemisinin and lumefantrine after administration of a single dose of 80/480 mg of artemether/lumefantrine to HIV-infected adults, taken with and without lopinavir/ritonavir. Methods A two-arm parallel study of 13 HIV-infected ART-naive adults and 16 HIV-infected adults stable on 400/100 mg of lopinavir/ritonavir plus two nucleoside reverse transcriptase inhibitors (ClinicalTrials.gov, NCT 00619944). Each participant received a single dose of 80/480 mg of artemether/lumefantrine under continuous cardiac function monitoring. Plasma concentrations of artemether, dihydroartemisinin and lumefantrine were measured. Results Co-administration of artemether/lumefantrine with lopinavir/ritonavir significantly reduced artemether maximum concentration (Cmax) and area under the concentration–time curve (AUC) [median (range): 112 (20–362) versus 56 (17–236) ng/mL, P = 0.03; and 264 (92–1129) versus 151 (38–606) ng · h/mL, P < 0.01]. Dihydroartemisinin Cmax and AUC were not affected [66 (10–111) versus 73 (31–224) ng/mL, P = 0.55; and 213 (68–343) versus 175 (118–262) ng · h/mL P = 0.27]. Lumefantrine Cmax and AUC increased during co-administration [2532 (1071–5957) versus 7097 (2396–9462) ng/mL, P < 0.01; and 41 119 (12 850–125 200) versus 199 678 (71 205–251 015) ng · h/mL, P < 0.01]. Conclusions Co-administration of artemether/lumefantrine with lopinavir/ritonavir significantly increases lumefantrine exposure, but decreases artemether exposure. Population pharmacokinetic and pharmacodynamic trials will be highly valuable in evaluating the clinical significance of this interaction and determining whether dosage modifications are indicated. PMID:22316571

  14. No significant brain volume decreases or increases in adults with high-functioning autism spectrum disorder and above average intelligence: a voxel-based morphometric study.

    PubMed

    Riedel, Andreas; Maier, Simon; Ulbrich, Melanie; Biscaldi, Monica; Ebert, Dieter; Fangmeier, Thomas; Perlov, Evgeniy; Tebartz van Elst, Ludger

    2014-08-30

    Autism spectrum disorder (ASD) is increasingly being recognized as an important issue in adult psychiatry and psychotherapy. High intelligence indicates overall good brain functioning and might thus present a particularly good opportunity to study possible cerebral correlates of core autistic features in terms of impaired social cognition, communication skills, the need for routines, and circumscribed interests. Anatomical MRI data sets for 30 highly intelligent patients with high-functioning autism and 30 pairwise-matched control subjects were acquired and analyzed with voxel-based morphometry. The gray matter volume of the pairwise-matched patients and the controls did not differ significantly. When correcting for total brain volume influences, the patients with ASD exhibited smaller left superior frontal volumes on a trend level. Heterogeneous volumetric findings in earlier studies might partly be explained by study samples biased by a high inclusion rate of secondary forms of ASD, which often go along with neuronal abnormalities. Including only patients with high IQ scores might have decreased the influence of secondary forms of ASD and might explain the absence of significant volumetric differences between the patients and the controls in this study. PMID:24953998

  15. A brominated-fluorene insect neuropeptide analog exhibits pyrokinin/PBAN-specific toxicity for adult females of the tobacco budworm moth.

    PubMed

    Teal, Peter E A; Nachman, Ronald J

    2002-04-01

    An analog of the insect pyrokinin/PBAN class of neuropeptides, which features a 2-amino7-bromofluorene attached to the carboxy-terminal bioactive core of the insect pyrokinin/PBAN class of neuropeptides (Phe-Thr-Pro-Arg-Leu-NH(2)), via a succinnic acid linker, was tested in adult H. virescens moths. This analog was found to induce pheromone production when injected into or applied topically to moths. Topical application of as much as 1 nmol of the analog to moths induced production of significant amounts of pheromone for only 1-2 h, whereas injection of 500 pmol induced pheromone production for up to 20 h. All insects died within 24 h after injection of 500 pmol of the analog. Mortality studies indicated that the LD(50) for the analog was 0.7 pmol when injected. A non-pyrokinin/PBAN peptide analog formed by attachment of 2-amino-7-bromofluorene to Ala-Ala-Arg-Ala-Ala-NH(2) (via the succinnic acid linker) did not induce mortality when injected at 1 nmol. Similarly no mortality was found when up to 2 nmol of an analog containing a non-brominated fluorene ring, formed by attachment of 9-fluoreneacetic acid to Phe-Thr-Pro-Arg-Leu-NH(2,) was injected into moths. The data indicated that both the bromine and active core of the pyrokinin neuropeptides (Phe-Thr-Pro-Arg-Leu-NH(2)) were critical for a specific toxic action and suggested that the brominated analog poisoned the moths by interacting with pyrokinin receptors. PMID:11897401

  16. Zinc-Oxide Nanoparticles Exhibit Genotoxic, Clastogenic, Cytotoxic and Actin Depolymerization Effects by Inducing Oxidative Stress Responses in Macrophages and Adult Mice.

    PubMed

    Pati, Rashmirekha; Das, Ishani; Mehta, Ranjit Kumar; Sahu, Rojalin; Sonawane, Avinash

    2016-04-01

    Zinc oxide nanoparticles (ZnO-NPs) have wide biological applications, which have raised serious concerns about their impact on the health and environment. Although, various studies have shown ZnO-NP toxicity on different cells underin vitroconditions, sufficient information is lacking regarding toxicity and underlying mechanisms underin vivoconditions. In this work, we investigated genotoxic, clastogenic, and cytotoxic effects of ZnO-NPs on macrophages and in adult mice. ZnO-NP-treated mice showed signs of toxicity such as loss in body weight, passive behavior and reduced survival. Further mechanistic studies revealed that administration of higher dose caused severe DNA damage in peripheral blood and bone marrow cells as evident by the formation of COMET tail, micronuclei, chromosomal fragmentation, and phosphorylation of H2A histone family member X. Moreover, ZnO-NPs inhibited DNA repair mechanism by downregulating the expression offen-1andpolBproteins. Histopathological examinations showed severe inflammation and damage to liver, lungs, and kidneys. Cell viability and wound healing assays revealed that ZnO-NPs killed macrophages in a dose-dependent manner, caused severe wounds and inhibited cellular migration by irreversible actin depolymerization and degradation. Reduction in the viability of macrophages was due to the arrest of the cell cycle at the G0/G1 phase, inhibition of superoxide dismutase and catalase and eventually reactive oxygen species. Furthermore, treatment with an antioxidant drug N-acetyl cysteine significantly reduced the ZnO-NP induced genotoxicity bothin vitroandin vivo Altogether, this study gives detailed pathological insights of ZnO-NP that impair cellular functions, thus will enable to arbitrate their biological applications. PMID:26794139

  17. Impaired Autophagy in Adult Bone Marrow CD34+ Cells of Patients with Aplastic Anemia: Possible Pathogenic Significance

    PubMed Central

    Huang, Jinbo; Ge, Meili; Lu, Shihong; Shi, Jun; Yu, Wei; Li, Xingxin; Wang, Min; Zhang, Jizhou; Feng, Sizhou; Dong, Shuxu; Cheng, Xuelian; Zheng, Yizhou

    2016-01-01

    Aplastic anemia (AA) is a bone marrow failure syndrome that is caused largely by profound quantitative and qualitative defects of hematopoietic stem and progenitor cells. However, the mechanisms underlying these defects remain unclear. Under conditions of stress, autophagy acts as a protective mechanism for cells. We therefore postulated that autophagy in CD34+ hematopoietic progenitor cells (HPCs) from AA patients might be impaired and play a role in the pathogenesis of AA. To test this hypothesis, we tested autophagy in CD34+ cells from AA samples and healthy controls and investigated the effect of autophagy on the survival of adult human bone marrow CD34+ cells. We found that the level of autophagy in CD34+ cells from AA patients was significantly lower than in age/sex-matched healthy controls, and lower in cases of severe AA than in those with non-severe AA. Autophagy in CD34+ cells improved upon amelioration of AA but, compared to healthy controls, was still significantly reduced even in AA patients who had achieved a complete, long-term response. We also showed that although the basal autophagy in CD34+ cells was low, the autophagic response of CD34+ cells to “adversity” was rapid. Finally, impaired autophagy resulted in reduced differentiation and proliferation of CD34+ cells and sensitized them to death and apoptosis. Thus, our results confirm that autophagy in CD34+ cells from AA patients is impaired, that autophagy is required for the survival of CD34+ cells, and that impaired autophagy in CD34+ HPCs may play an important role in the pathogenesis of AA. PMID:26930650

  18. Vitamin and Mineral Supplements Have a Nutritionally Significant Impact on Micronutrient Intakes of Older Adults Attending Senior Centers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Background: Older adults frequently report use of vitamin and mineral (VM) supplements, though the impact of supplements on dietary adequacy remains largely unknown. Despite possible improvements in dietary intake, concern remains over potential excessive nutrient consumption from VM supplement us...

  19. Six Year Refractive Change among White Children and Young Adults: Evidence for Significant Increase in Myopia among White UK Children

    PubMed Central

    2016-01-01

    Objective To determine six-year spherical refractive error change among white children and young adults in the UK and evaluate differences in refractive profiles between contemporary Australian children and historical UK data. Design Population-based prospective study. Participants The Northern Ireland Childhood Errors of Refraction (NICER) study Phase 1 examined 1068 children in two cohorts aged 6–7 years and 12–13 years. Prospective data for six-year follow-up (Phase 3) are available for 212 12–13 year olds and 226 18–20 year olds in each cohort respectively. Methods Cycloplegic refractive error was determined using binocular open-field autorefraction (Shin-Nippon NVision-K 5001, cyclopentolate 1%). Participants were defined by spherical equivalent refraction (SER) as myopic SER ≤-0.50D, emmetropic -0.50Dsignificantly increased between 6–7 years (1.9%) and 12–13 years (14.6%) (p<0.001) but not between 12–13 and 18–20 years (16.4% to 18.6%, p = 0.51). The estimated annual incidence of myopia was 2.2% and 0.7% for the younger and older cohorts respectively. There were significantly more myopic children in the UK at age 12–13 years in the NICER study (16.4%) than reported in Australia (4.4%) (p<0.001). However by 17 years the proportion of myopia neared equivalence in the two populations (NICER 18.6%, Australia 17.7%, p = 0.75). The proportion of myopic children aged 12–13 years in the present study (2006–2008) was 16.4%, significantly greater than that reported for children aged 10–16 years in the 1960’s (7.2%, p = 0.01). The proportion of hyperopes in the younger NICER cohort decreased significantly over the six year period (from 21.7% to 14.2%, p = 0.04). Hyperopes with SER ≥+3.50D in both NICER age cohorts demonstrated persistent hyperopia. Conclusions The incidence and proportion of myopia are relatively

  20. Associations between hurtful weight-related comments by family and significant other and the development of disordered eating behaviors in young adults

    PubMed Central

    Eisenberg, Marla E.; Berge, Jerica M.; Fulkerson, Jayne A.; Neumark-Sztainer, Dianne

    2012-01-01

    Background Research has found that weight-teasing is associated with disordered eating in adolescents. This study expands on the existing research by examining associations between hurtful weight comments by family and a significant other and disordered eating in young adults. Methods Data come from 1,902 young adults (mean age 25) who completed surveys in 1998, 2003 and 2009. Correlations were examined between receiving hurtful comments from family and significant others, and four disordered eating behaviors in young adulthood, adjusting for prior disordered eating and prior teasing. Results Disordered eating behaviors were common in young adulthood, and were associated with hearing hurtful weight-related comments from family members and a significant other, for both females and males. Conclusion Disordered eating prevention activities, which include messages about the potential harm associated with hurtful weight-related comments, should be expanded to address young adults, and programs may want to target relationship partners. PMID:21898148

  1. Adult Trade Apprentices: Exploring the Significance of Recognition of Prior Learning and Skill Sets for Earlier Completion. Research Report

    ERIC Educational Resources Information Center

    Hargreaves, Jo; Blomberg, Davinia

    2015-01-01

    The nature of apprenticeships is changing. Increasing proportions of adult apprentices are prompting demand for various alternative pathways to completion. One option for an alternative pathway to accelerate completion is the use of recognition of prior learning (RPL) to identify existing skills and knowledge in combination with gap training. This…

  2. Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty.

    PubMed

    Pita, Jimena; Barrios, Vicente; Gavela-Pérez, Teresa; Martos-Moreno, Gabriel Á; Muñoz-Calvo, María T; Pozo, Jesús; Rovira, Adela; Argente, Jesús; Soriano-Guillén, Leandro

    2011-09-01

    The system KISS1-KISS1R is one of the main regulators of the hypothalamic-pituitary-gonadal axis and constitutes a link between metabolism and reproduction through its interaction with leptin. The aim of this study was to clarify the possible utility of kisspeptin as a pubertal marker and/or the possible influence of nutritional status in kisspeptin levels. To this end, we have studied kisspeptin plasma levels throughout sexual development and in prepubertal obese girls and girls affected by idiopathic central precocious puberty (CPP). Plasma kisspeptin concentrations were analyzed by RIA. An increase in kisspeptin levels was observed in adult females compared to healthy prepubertal and pubertal girls (p<0.001) and to adult males (p<0.001). Additionally, kisspeptin was increased in prepubertal obese girls compared to healthy prepubertal girls (p<0.01) and girls with idiopathic CPP (p<0.05). As revealed by the regression analysis, in prepubertal healthy and obese girls and girls with idiopathic CCP, the parameters that influenced kisspeptin levels were BMI (R(2)=0.10, p<0.05) and leptin levels (R(2)=0.14, p<0.01). In conclusion, kisspeptin levels do not seem to be a good pubertal marker. The results obtained in prepubertal and idiopathic CCP girls point to a relationship between leptin, BMI and kisspeptin at least in this group, and suggest a possible role for adipose tissue in the modulation kisspeptin synthesis. PMID:21827808

  3. The Impact of DSM-IV Symptom and Clinical Significance Criteria on the Prevalence Estimates of Subthreshold and Threshold Anxiety in the Older Adult Population

    PubMed Central

    Grenier, Sébastien; Préville, Michel; Boyer, Richard; O’Connor, Kieron; Béland, Sarah-Gabrielle; Potvin, Olivier; Hudon, Carol; Brassard, Joëlle

    2013-01-01

    Objectives Subthreshold anxiety refers to a condition where individuals do not meet the full symptom criteria (i.e., the number of symptoms required for a formal diagnosis is not reached) and/or do not report significant impairment or distress in functioning (i.e., the clinical significance criterion is not met). The purpose of this study was to examine how the symptom and the clinical significance criteria may affect the prevalence estimates of anxiety problems in the older adult population and whether applying these criteria results in an identifiable older group showing more severe anxiety. Setting and Participants Data came from a large representative sample of community-dwelling older adults age 65 years and older (N = 2,784). Results Results showed that the 12-month prevalence rate of any anxiety problem varied from 5.6% when DSM-IV criteria for anxiety disorders were used to 26.2% when all subthreshold manifestations of anxiety were considered. Findings also indicated that when compared with respondents without anxiety, older adults presenting different manifestations of subthreshold or threshold anxiety appear to be more similar than different in their health and health behavior characteristics. Conclusions Subthreshold anxiety has a high prevalence and may cause significant impairment. Both symptom and clinical significance criteria do not perfectly discriminate between older adults with or without a severe anxiety problem presenting comorbid disorders and needing psychiatric help. PMID:21427640

  4. Cognitive behavior therapy-based psychoeducational groups for adults with ADHD and their significant others (PEGASUS): an open clinical feasibility trial.

    PubMed

    Hirvikoski, T; Waaler, E; Lindström, T; Bölte, S; Jokinen, J

    2015-03-01

    The aim of this pilot study was to investigate the feasibility and effectiveness of a new psychoeducative intervention program (PEGASUS) for adults with ADHD and their significant others in a psychiatric outpatient context. At three outpatient psychiatric clinics, adults with ADHD and their significant others took part in PEGASUS, a psychoeducational program based on theories from cognitive behavioral therapy, neuropsychology, and cross-disciplinary evidence regarding ADHD. In total, 108 adults were allocated to treatment (51 with ADHD and their 57 significant others). Feasibility was evaluated regarding suitability of the intervention at a psychiatric outpatient clinic and treatment completion. Preliminary efficacy was evaluated per protocol from baseline to post-intervention (n = 41 adults with ADHD and 40 significant others). In a feasibility analysis, the intervention was judged to be a suitable treatment option for 94.5 % of all individuals with a primary diagnosis of ADHD at an outpatient psychiatric clinic. In total, 43 out of 51 allocated individuals with ADHD (84.3 %) completed the intervention. The corresponding figures for their significant others were 42 out of 57 (73.7 %). Knowledge about ADHD increased, and both the quality of relationships and psychological well-being improved from baseline to post-intervention in all participants. The significant others reported a reduction in the subjective burden of care, such as worry and guilt. The objective burden of care (such as financial problems) did not change. The findings support the potential value of psychoeducation for adults with ADHD and their significant others. An ongoing randomized controlled trial will generate further evidence concerning the PEGASUS program. PMID:24863143

  5. Varying protein source and quantity does not significantly improve weight loss, fat loss, or satiety in reduced energy diets among midlife adults

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This pilot study tested whether varying protein source and quantity in a reduced energy diet would result in significant differences in weight, body composition, and renin angiotensin aldosterone system activity in midlife adults. Eighteen subjects enrolled in a 5 month weight reduction study, invol...

  6. Effects of Multimedia Social Stories on Knowledge of Adult Outcomes and Opportunities among Transition-Aged Youth with Significant Cognitive Disabilities

    ERIC Educational Resources Information Center

    Richter, Sharon; Test, David

    2011-01-01

    Students with significant cognitive disabilities typically experience poor post-school outcomes as adults. Federal legislation and recent research reflect the importance of teaching self-determination skills as a strategy to improve post-school outcomes. However, the National Longitudinal Transition Study-2 (NLTS-2) reported that individuals with…

  7. Discrete-Trial Functional Analysis of Problem Behavior and Functional Communication Training in Three Adults with a Dual Diagnosis of a Significant Intellectual Disability and a Mental Illness

    ERIC Educational Resources Information Center

    Chezan, Laura Claudia

    2012-01-01

    I conducted two studies. First, I examined the applicability of discrete-trial functional analysis (DTFA) for identifying the function of problem behavior in three adults with a dual diagnosis of a significant intellectual disability and a mental illness. Results indicated clear patterns of problem behavior for each participant. Second, I used a…

  8. Significant Discrepancies between the Wechsler Adult Intelligence Scale--Revised and the Woodcock-Johnson Psycho-Educational Battery, Part II: Tests of Achievement with a College Population.

    ERIC Educational Resources Information Center

    Salvia, Shawn Amig; Salvia, John

    1986-01-01

    Significant differences were found between college freshmen science (N=50) and nonscience (N=50) majors who were administered the Wechsler Adult Intelligence Scale--Revised (WAIS-R) and the Woodcock-Johnson Psycho-Educational Battery, Part II: Tests of Achievement. (Author/CB)

  9. Prognostic Significance and Treatment Implications of Minimal Residual Disease Studies in Philadelphia-Negative Adult Acute Lymphoblastic Leukemia

    PubMed Central

    Spinelli, Orietta; Tosi, Manuela; Peruta, Barbara; Guinea Montalvo, Marie Lorena; Maino, Elena; Scattolin, Anna Maria; Parolini, Margherita; Viero, Piera; Rambaldi, Alessandro; Bassan, Renato

    2014-01-01

    Acute lymphoblastic leukemia (ALL) is curable in about 40–50% of adult patients, however this is subject to ample variations owing to several host- and disease-related prognostic characteristics. Currently, the study of minimal residual disease (MRD) following induction and early consolidation therapy stands out as the most sensitive individual prognostic marker to define the risk of relapse following the achievement of remission, and ultimately that of treatment failure or success. Because substantial therapeutic advancement is now being achieved using intensified pediatric-type regimens, MRD analysis is especially useful to orientate stem cell transplantation choices. These strategic innovations are progressively leading to greater than 50% cure rates. PMID:25237475

  10. Significance of high voltage QRS anterior forces in young asymptomatic adults. Evaluation by wide-angle two-dimensional echocardiography.

    PubMed

    Loperfido, F; Digaetano, A; Pennestri, F; Mongiardo, R; Infantino, S; Fanelli, R; Guccione, P; Coppola, E

    1983-07-01

    Thirteen asymptomatic adults less than 40 years old who showed tall right precordial R waves on the ECG were examined by VCG, M-mode and two-dimensional echocardiography (2D Echo). Common causes of QRS anterior displacement, such as right ventricular enlargement or right bundle branch block, were excluded in each subject. Although each subject was normal at physical examination, 2D Echo revealed areas of left ventricular hypertrophy in eight of these 13 subjects. Four had a prevailing hypertrophy of the basal portion of the interventricular septum, three had an isolated apical hypertrophy, and one had a diffuse concentric left ventricular hypertrophy. Results were normal in five cases. 2D Echo classification was confirmed by heart catheterization findings, when available. The subjects with asymmetric septal hypertrophy showed low-voltage QRS leftward forces on the ECG and VCG. ECGs and VCGs were not useful in differentiating the subjects with atypically distributed left ventricular hypertrophy from the normals: high-voltage QRS leftward forces and T wave abnormalities were evident in some subjects of both groups. Tall right precordial R waves may constitute a marker of hypertrophic cardiomyopathy in asymptomatic young adults. 2D Echo is useful to exactly classify these subjects. PMID:6225816

  11. Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Anti-Tumor Activity in Cancer Cells that Display Resistance to Proapoptotic Stimuli: an Investigation of Structure-Activity Relationship and Mechanistic Insight

    PubMed Central

    Lamoral-Theys, Delphine; Andolfi, Anna; Van Goietsenoven, Gwendoline; Cimmino, Alessio; Le Calvé, Benjamin; Wauthoz, Nathalie; Mégalizzi, Véronique; Gras, Thierry; Bruyère, Céline; Dubois, Jacques; Mathieu, Véronique; Kornienko, Alexander; Kiss, Robert; Evidente, Antonio

    2011-01-01

    Twenty-two lycorine-related compounds were investigated for in vitro anti-tumor activity using four cancer cell lines displaying different levels of resistance to pro-apoptotic stimuli and two cancer cell lines sensitive to pro-apoptotic stimuli. Lycorine and six of its congeners exhibited potency in the single-digit micromolar range, while no compound appeared more active than lycorine. Lycorine also displayed the highest potential (in vitro) therapeutic ratio, being at least 15 times more active against cancer than normal cells. Our studies also showed that lycorine exerts its in vitro anti-tumor activity through cytostatic rather than cytotoxic effects. Furthermore, lycorine provided significant therapeutic benefit in mice bearing brain grafts of the B16F10 melanoma model at non-toxic doses. Thus, the results of the current study make lycorine an excellent lead for the generation of compounds able to combat cancers, which are naturally resistant to pro-apoptotic stimuli, such as glioblastoma, melanoma, non-small-cell-lung cancers, metastatic cancers, among others. PMID:19788245

  12. Metallothionein I,II deficient mice do not exhibit significantly worse long-term behavioral outcomes following neonatal hypoxia-ischemia: MT-I,II deficient mice have inherent behavioral impairments.

    PubMed

    McAuliffe, John J; Joseph, Bernadin; Hughes, Elizabeth; Miles, Lili; Vorhees, Charles V

    2008-01-23

    Metallothionein I and II are small metal binding proteins with a high affinity for zinc. They are found in the CNS and are thought to play a role in modulating the effects of free zinc. We hypothesized that MT-I,II deficient mice would have more neurological deficits both functionally and anatomically following a neonatal hypoxic-ischemic (HI) insult than wild-type mice subjected to the same insult. Forty wild-type and 40 MT-I,II deficient C57 X 129T2 F1 P10 mice were randomized to either 45 min of HI or sham HI. Beginning on P50, the mice were given a series of behavioral tests including locomotor activity, novel object recognition, Morris water maze (cued, hidden platform, reduced platform), a 2-week-delayed probe trial and an apomorphine-induced rotation test. At the conclusion of testing, the brains were removed for histological analysis including staining with NeuN and GFAP to assess neuronal loss and reactive gliosis. There were no significant differences in functional or anatomic measures between the wild-type HI mice and the MT-I,II deficient HI mice. The MT-I,II deficient mice exhibited an impaired rate of learning in the spatially oriented mazes but once learned retained the information as well as the wild-type mice. The absence of functional MT-I,II proteins does not result in significantly worse injury following 45 min of HI on P10. The MT-I,II deficient mice have baseline impairments in spatial learning but not retention. PMID:18083145

  13. Electrogastrography in Adults and Children: The Strength, Pitfalls, and Clinical Significance of the Cutaneous Recording of the Gastric Electrical Activity

    PubMed Central

    Indrio, Flavia

    2013-01-01

    Cutaneous electrogastrography (EGG) is a non-invasive technique to record gastric myoelectrical activity from the abdominal surface. Although the recent rapid increase in the development of electrocardiography, EGG still suffers from several limitations. Currently, computer analysis of EGG provides few reliable parameters, such as frequency and the percentage of normal and altered slow wave activity (bradygastria and tachygastria). New EGG hardware and software, along with an appropriate arrangement of abdominal electrodes, could detect the coupling of the gastric slow wave from the EGG. At present, EGG does not diagnose a specific disease, but it puts in evidence stomach motor dysfunctions in different pathological conditions as gastroparesis and functional dyspepsia. Despite the current pitfalls of EGG, a multitasking diagnostic protocol could involve the EGG and the 13C-breath testing for the evaluation of the gastric emptying time—along with validated gastrointestinal questionnaires and biochemical evaluations of the main gastrointestinal peptides—to identify dyspeptic subgroups. The present review tries to report the state of the art about the pathophysiological background of the gastric electrical activity, the recording and processing methodology of the EGG with particular attention to multichannel recording, and the possible clinical application of the EGG in adult and children. PMID:23762836

  14. Clinically Significant Fatigue: Prevalence and Associated Factors in an International Sample of Adults with Multiple Sclerosis Recruited via the Internet

    PubMed Central

    Weiland, Tracey J.; Jelinek, George A.; Marck, Claudia H.; Hadgkiss, Emily J.; van der Meer, Dania M.; Pereira, Naresh G.; Taylor, Keryn L.

    2015-01-01

    Background Fatigue contributes a significant burden of disease for people with multiple sclerosis (PwMS). Modifiable lifestyle factors have been recognized as having a role in a range of morbidity outcomes in PwMS. There is significant potential to prevent and treat fatigue in PwMS by addressing modifiable risk factors. Objectives To explore the associations between clinically significant fatigue and demographic factors, clinical factors (health-related quality of life, disability and relapse rate) and modifiable lifestyle, disease-modifying drugs (DMD) and supplement use in a large international sample of PwMS. Methods PwMS were recruited to the study via Web 2.0 platforms and completed a comprehensive survey measuring demographic, lifestyle and clinical characteristics, including health-related quality of life, disability, and relapse rate. Results Of 2469 participants with confirmed MS, 2138 (86.6%) completed a validated measure of clinically significant fatigue, the Fatigue Severity Scale. Participants were predominantly female from English speaking countries, with relatively high levels of education, and due to recruitment methods may have been highly pro-active about engaging in lifestyle management and self-help. Approximately two thirds of our sample (1402/2138; 65.6% (95% CI 63.7–67.7)) screened positive for clinically significant fatigue. Bivariate associations were present between clinically significant fatigue and several demographic, clinical, lifestyle, and medication variables. After controlling for level of disability and a range of stable socio-demographic variables, we found increased odds of fatigue associated with obesity, DMD use, poor diet, and reduced odds of fatigue with exercise, fish consumption, moderate alcohol use, and supplementation with vitamin D and flaxseed oil. Conclusion This study supports strong and significant associations between clinically significant fatigue and modifiable lifestyle factors. Longitudinal follow-up of this

  15. Use of Context in the Word Recognition Process by Adults with a Significant History of Reading Difficulties

    ERIC Educational Resources Information Center

    Corkett, Julie K.; Parrila, Rauno

    2008-01-01

    We examined whether university students who report a significant history of reading difficulties (RD; n=24) differed from university students with no history of reading difficulties (NRD; n=31) in how sentence context affects word recognition. Experiment 1 found no differences in how congruent sentence primes or syntactic manipulations of the…

  16. The majority of adult pneumococcal invasive infections in Portugal are still potentially vaccine preventable in spite of significant declines of serotypes 1 and 5.

    PubMed

    Horácio, Andreia N; Diamantino-Miranda, Jorge; Aguiar, Sandra I; Ramirez, Mário; Melo-Cristino, José

    2013-01-01

    In Portugal, pneumococcal conjugate vaccines have been administered to children outside of the national immunization plan since 2001. We determined the serotype and antimicrobial susceptibility of 1265 isolates responsible for adult invasive pneumococcal infections (IPD) between 2009 and 2011 and compared the results with previously published data from 1999 to 2008. Serotypes 3 (12.6%), 7F (10.0%), 19A (9.1%), 14 (8.4%), 1 (6.9%) and 8 (6.2%) were the most frequent and together accounted for 53.2% of adult IPD. Serotypes 1 and 5 declined significantly while serotype 34, not included in any vaccine, increased. Taken together, the serotypes included in the 13-valent conjugate vaccine (PCV13) peaked among adult IPD isolates in 2008 (70.2%) and declined since then reaching 53.5% in 2011. The decline in the serotypes included in the 23-valent polysaccharide vaccine since 2007 was also significant but much more modest with 79.2% of the isolates causing IPD in 2011 expressing these serotypes. Since the changes in serotypes causing IPD in adults coincided with the 10-valent and PCV13 introduction in children, it is unlikely that vaccination triggered these changes although it may have accelerated them. The proportion of IPD caused by serotypes included in the 7-valent conjugate vaccine remained stable (19.0%). Both penicillin non-susceptibility and erythromycin resistance increased in the study period, with serotypes 14 and 19A accounting for the majority of resistant isolates. PMID:24066064

  17. The significance of the host inflammatory response on the therapeutic efficacy of cell therapies utilising human adult stem cells

    SciTech Connect

    Navarro, Melba; Pu, Fanrong; Hunt, John A.

    2012-02-15

    Controlling the fate of implanted hMSCs is one of the major drawbacks to be overcome to realize tissue engineering strategies. In particular, the effect of the inflammatory environment on hMSCs behaviour is poorly understood. Studying and mimicking the inflammatory process in vitro is a very complex and challenging task that involves multiple variables. This research addressed the questions using in vitro co-cultures of primary derived hMSCs together with human peripheral blood mononucleated cells (PBMCs); the latter are key agents in the inflammatory process. This work explored the in vitro phenotypic changes of hMSCs in co-culture direct contact with monocytes and lymphocytes isolated from blood using both basal and osteogenic medium. Our findings indicated that hMSCs maintained their undifferentiated phenotype and pluripotency despite the contact with PBMCs. Moreover, hMSCs demonstrated increased proliferation and were able to differentiate specifically down the osteogenic lineage pathway. Providing significant crucial evidence to support the hypothesis that inflammation and host defence mechanisms could be utilised rather than avoided and combated to provide for the successful therapeutic application of stem cell therapies.

  18. Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults

    PubMed Central

    Mather, Karen A.; Thalamuthu, Anbupalam; Oldmeadow, Christopher; Song, Fei; Armstrong, Nicola J.; Poljak, Anne; Holliday, Elizabeth G.; McEvoy, Mark; Kwok, John B.; Assareh, Amelia A.; Reppermund, Simone; Kochan, Nicole A.; Lee, Teresa; Ames, David; Wright, Margaret J.; Trollor, Julian N.; Schofield, Peter W.; Brodaty, Henry; Scott, Rodney J.; Schofield, Peter R.; Attia, John R.; Sachdev, Perminder S.

    2016-01-01

    Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH levels have high heritability. We undertook a genome-wide association study of ApoH levels using the largest sample to date and replicated the results in an independent cohort (total N = 1,255). In the discovery phase, a meta-analysis of two cohorts, the Sydney Memory and Ageing Study (Sydney MAS) and the Older Australian Twins Study (OATS) (n = 942) revealed genome-wide significant results in or near the APOH gene on chromosome 17 (top SNP, rs7211380, p = 1 × 10−11). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = 313). Conditional and joint analysis (COJO) confirmed the association of the chromosomal 17 region with ApoH levels. The set of independent SNPs identified by COJO explained 23% of the variance. The relationships between the top SNPs and cardiovascular/lipid/cognition measures and diabetes were assessed in Sydney MAS, with suggestive results observed for diabetes and cognitive performance. However, replication of these results in the smaller OATS cohort was not found. This work provides impetus for future research to better understand the contribution of genetics to ApoH levels and its possible impacts on health. PMID:27030319

  19. Genome-wide significant results identified for plasma apolipoprotein H levels in middle-aged and older adults.

    PubMed

    Mather, Karen A; Thalamuthu, Anbupalam; Oldmeadow, Christopher; Song, Fei; Armstrong, Nicola J; Poljak, Anne; Holliday, Elizabeth G; McEvoy, Mark; Kwok, John B; Assareh, Amelia A; Reppermund, Simone; Kochan, Nicole A; Lee, Teresa; Ames, David; Wright, Margaret J; Trollor, Julian N; Schofield, Peter W; Brodaty, Henry; Scott, Rodney J; Schofield, Peter R; Attia, John R; Sachdev, Perminder S

    2016-01-01

    Apolipoprotein H (ApoH) is a multi-functional plasma glycoprotein that has been associated with negative health outcomes. ApoH levels have high heritability. We undertook a genome-wide association study of ApoH levels using the largest sample to date and replicated the results in an independent cohort (total N = 1,255). In the discovery phase, a meta-analysis of two cohorts, the Sydney Memory and Ageing Study (Sydney MAS) and the Older Australian Twins Study (OATS) (n = 942) revealed genome-wide significant results in or near the APOH gene on chromosome 17 (top SNP, rs7211380, p = 1 × 10(-11)). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = 313). Conditional and joint analysis (COJO) confirmed the association of the chromosomal 17 region with ApoH levels. The set of independent SNPs identified by COJO explained 23% of the variance. The relationships between the top SNPs and cardiovascular/lipid/cognition measures and diabetes were assessed in Sydney MAS, with suggestive results observed for diabetes and cognitive performance. However, replication of these results in the smaller OATS cohort was not found. This work provides impetus for future research to better understand the contribution of genetics to ApoH levels and its possible impacts on health. PMID:27030319

  20. Significance Analysis of Microarrays (SAM) Offers Clues to Differences Between the Genomes of Adult Philadelphia Positive ALL and the Lymphoid Blast Transformation of CML

    PubMed Central

    Grace, Colin; Nacheva, Elisabeth P.

    2012-01-01

    Philadelphia positive malignant disorders are a clinically divergent group of leukemias. These include chronic myeloid leukemia (CML) and de novo acute Philadelphia positive (Ph(+)) leukemia of both myeloid, and lymphoid origin. Recent whole genome screening of Ph(+)ALL in both children and adults identified an almost obligatory cryptic loss of Ikaros, required for the normal B cell maturation. Although similar losses were found in lymphoid blast crisis the genetic background of the transformation in CML is still poorly defined. We used Significance Analysis of Microarrays (SAM) to analyze comparative genomic hybridization (aCGH) data from 30 CML (10 each of chronic phase, myeloid and lymphoid blast stage), 10 Ph(+)ALL adult patients and 10 disease free controls and were able to: (a) discriminate between the genomes of lymphoid and myeloid blast cells and (b) identify differences in the genome profile of de novo Ph(+)ALL and lymphoid blast transformation of CML (BC/L). Furthermore we were able to distinguish a sub group of Ph(+) ALL characterized by gains in chromosome 9 and recurrent losses at several other genome sites offering genetic evidence for the clinical heterogeneity. The significance of these results is that they not only offer clues regarding the pathogenesis of Ph(+) disorders and highlight the potential clinical implications of a set of probes but also demonstrates what SAM can offer for the analysis of genome data. PMID:23071388

  1. BMI, HOMA-IR, and Fasting Blood Glucose Are Significant Predictors of Peripheral Nerve Dysfunction in Adult Overweight and Obese Nondiabetic Nepalese Individuals: A Study from Central Nepal

    PubMed Central

    Thapa, Lekhjung; Rana, P. V. S.

    2016-01-01

    Objective. Nondiabetic obese individuals have subclinical involvement of peripheral nerves. We report the factors predicting peripheral nerve function in overweight and obese nondiabetic Nepalese individuals. Methodology. In this cross-sectional study, we included 50 adult overweight and obese nondiabetic volunteers without features of peripheral neuropathy and 50 healthy volunteers to determine the normative nerve conduction data. In cases of abnormal function, the study population was classified on the basis of the number of nerves involved, namely, “<2” or “≥2.” Multivariable logistic regression analysis was carried out to predict outcomes. Results. Fasting blood glucose (FBG) was the significant predictor of motor nerve dysfunction (P = 0.039, 95% confidence interval (CI) = 1.003–1.127). Homeostatic model assessment of insulin resistance (HOMA-IR) was the significant predictor (P = 0.019, 96% CI = 1.420–49.322) of sensory nerve dysfunction. Body mass index (BMI) was the significant predictor (P = 0.034, 95% CI = 1.018–1.577) in case of ≥2 mixed nerves' involvement. Conclusion. FBG, HOMA-IR, and BMI were significant predictors of peripheral nerve dysfunction in overweight and obese Nepalese individuals. PMID:27200189

  2. BMI, HOMA-IR, and Fasting Blood Glucose Are Significant Predictors of Peripheral Nerve Dysfunction in Adult Overweight and Obese Nondiabetic Nepalese Individuals: A Study from Central Nepal.

    PubMed

    Thapa, Lekhjung; Rana, P V S

    2016-01-01

    Objective. Nondiabetic obese individuals have subclinical involvement of peripheral nerves. We report the factors predicting peripheral nerve function in overweight and obese nondiabetic Nepalese individuals. Methodology. In this cross-sectional study, we included 50 adult overweight and obese nondiabetic volunteers without features of peripheral neuropathy and 50 healthy volunteers to determine the normative nerve conduction data. In cases of abnormal function, the study population was classified on the basis of the number of nerves involved, namely, "<2" or "≥2." Multivariable logistic regression analysis was carried out to predict outcomes. Results. Fasting blood glucose (FBG) was the significant predictor of motor nerve dysfunction (P = 0.039, 95% confidence interval (CI) = 1.003-1.127). Homeostatic model assessment of insulin resistance (HOMA-IR) was the significant predictor (P = 0.019, 96% CI = 1.420-49.322) of sensory nerve dysfunction. Body mass index (BMI) was the significant predictor (P = 0.034, 95% CI = 1.018-1.577) in case of ≥2 mixed nerves' involvement. Conclusion. FBG, HOMA-IR, and BMI were significant predictors of peripheral nerve dysfunction in overweight and obese Nepalese individuals. PMID:27200189

  3. The International Classification of Functioning, Disability and Health as a Framework for Providing Patient- and Family-Centered Audiological Care for Older Adults and Their Significant Others.

    PubMed

    Grenness, Caitlin; Meyer, Carly; Scarinci, Nerina; Ekberg, Katie; Hickson, Louise

    2016-08-01

    Hearing impairment is highly prevalent in the older population, and it impacts communication and quality of life for both the people with the hearing difficulties and their significant others. In this article, typical audiological assessment and management of an older adult is contrasted with a best practice approach wherein the World Health Organization's International Classification of Functioning, Disability and Health (ICF) framework is applied. The aim of the comparison is to demonstrate how the ICF expands our focus: rather than merely focusing on impairment, we also consider the activities, participation, and contextual factors for both the person with the hearing impairment and his or her family. A case example of an older patient and her spouse is provided, and their shared experience of the patient's hearing impairment is mapped onto the ICF framework. Family-centered hearing care is recommended for individualizing care and improving outcomes for older patients and their families. PMID:27489398

  4. Ethics on Exhibit

    ERIC Educational Resources Information Center

    Vick, Randy M.

    2011-01-01

    This article discusses ethical questions raised by an exhibition of work by an artist with a history of mental illness and the exhibition's relevance to art therapy and “outsider art” discourse on the subject. Considerations for how such an exhibit could be handled had the circumstances included an art therapist and art therapy client are…

  5. An Evidence-Based Education Program for Adults about Child Sexual Abuse ("Prevent It!") That Significantly Improves Attitudes, Knowledge, and Behavior.

    PubMed

    Martin, Erin K; Silverstone, Peter H

    2016-01-01

    Here we describe the development of an evidence-based education program for adults about childhood sexual abuse (CSA), called Prevent It! Uniquely, the primary goal of this program was to change the behavior of participants, as well as to increase knowledge about CSA and positive attitudes toward it. A comprehensive review shows no previous similar approach. The program includes a detailed manual to allow standardized administration by trained facilitators, as well as multiple video segments from CSA survivors and professionals. A total of 23 program workshops were run, with 366 adults participating. Of these, 312 (85%) agreed to take part in the study. All completed baseline ratings prior to the program and 195 (63% of study sample) completed follow-up assessments at 3-months. There were no significant differences between the demographic make-up of the baseline group and the follow-up group. Assessments included demographic data, knowledge, attitudes, and several measures of behavior (our primary outcome variable). Behavioral questions asked individuals to select behaviors used in the previous 3-months from a list of options. Questions also included asking "how many times in the previous 3-months" have you "talked about healthy sexual development or Child sexual abuse (CSA) with a child you know"; "suspected a child was sexually abused"; "taken steps to protect a child"; or "reported suspected sexual abuse to police or child welfare"? The majority of attendees were women, with the commonest age group being between 30 and 39 years old. Approximately 33% had experienced CSA themselves. At 3-month follow-up there were highly statistically significant improvements in several aspects of behavior and knowledge, and attitudes regarding CSA. For example, the number of subjects actively looking for evidence of CSA increased from 46% at baseline to 81% at follow-up, while the number of subjects who actively took steps to protect children increased from 25% at baseline to 48

  6. An Evidence-Based Education Program for Adults about Child Sexual Abuse (“Prevent It!”) That Significantly Improves Attitudes, Knowledge, and Behavior

    PubMed Central

    Martin, Erin K.; Silverstone, Peter H.

    2016-01-01

    Here we describe the development of an evidence-based education program for adults about childhood sexual abuse (CSA), called Prevent It! Uniquely, the primary goal of this program was to change the behavior of participants, as well as to increase knowledge about CSA and positive attitudes toward it. A comprehensive review shows no previous similar approach. The program includes a detailed manual to allow standardized administration by trained facilitators, as well as multiple video segments from CSA survivors and professionals. A total of 23 program workshops were run, with 366 adults participating. Of these, 312 (85%) agreed to take part in the study. All completed baseline ratings prior to the program and 195 (63% of study sample) completed follow-up assessments at 3-months. There were no significant differences between the demographic make-up of the baseline group and the follow-up group. Assessments included demographic data, knowledge, attitudes, and several measures of behavior (our primary outcome variable). Behavioral questions asked individuals to select behaviors used in the previous 3-months from a list of options. Questions also included asking “how many times in the previous 3-months” have you “talked about healthy sexual development or Child sexual abuse (CSA) with a child you know”; “suspected a child was sexually abused”; “taken steps to protect a child”; or “reported suspected sexual abuse to police or child welfare”? The majority of attendees were women, with the commonest age group being between 30 and 39 years old. Approximately 33% had experienced CSA themselves. At 3-month follow-up there were highly statistically significant improvements in several aspects of behavior and knowledge, and attitudes regarding CSA. For example, the number of subjects actively looking for evidence of CSA increased from 46% at baseline to 81% at follow-up, while the number of subjects who actively took steps to protect children increased from

  7. Maturation processes in automatic change detection as revealed by event-related brain potentials and dipole source localization: significance for adult AD/HD.

    PubMed

    Wild-Wall, Nele; Oades, Robert D; Juran, Stephanie A

    2005-10-01

    Mismatch negativity (MMN) is an event-related potential reflecting automatic attention-related information processing marking the detection of auditory change. The bilateral scalp distribution develops by 14 years of age, and is elicited with adult latencies by 17 years. But consistent with reports of continued brain maturation after adolescence, we show here that features of the temporal and frontal lobe dipole sources also continue to develop in the third decade of life. This has consequences for studies of the developmental course of MMN anomalies, from childhood into adulthood, in attention-deficit/hyperactivity disorder. Two groups of healthy subjects with mean ages of 17 and 30 years were presented with a 3-tone auditory oddball. The duration-deviant MMN was recorded during attention to a visual discrimination (auditory-passive condition) and an active auditory discrimination. MMN amplitudes were smaller in the older subjects and the MMN lasted longer over the right hemisphere. Latencies and moments of the four dipoles in the temporal and frontal lobes did not distinguish the two subject-groups. But both temporal lobe sources were located significantly more ventrally and further left in the young adult than in the adolescent subjects. The left cingular source moved posteriorly and the right inferior frontal source moved antero-medially in the older subjects. Brain development in the third decade may cause the two frontal sources to move apart on the rostro-caudal axis but the temporal lobe sources to move left on the lateral and down on the dorsoventral axes. Thus special care is necessary in interpreting putative dysfunctional neurobiological changes in developmental attention-deficit disorders where as-yet-unspecified sub-groups may show a late developmental lag, partial lag, or no lag at all, associated with other impairments. PMID:15922470

  8. An Exhibit for Touching.

    ERIC Educational Resources Information Center

    Hunt, Susan

    1979-01-01

    An exhibit designed for visually handicapped persons presented by the Kalamazoo (Michigan) Institute of Art included bronze sculptures and oil paintings from the institute's permanent collection. (CL)

  9. The Clinical Significance of Glycoprotein Phospholipase D Levels in Distinguishing Early Stage Latent Autoimmune Diabetes in Adults and Type 2 Diabetes

    PubMed Central

    Qin, Wen; Liang, Yu-Zhen; Qin, Bao-Yu; Zhang, Jia-Li; Xia, Ning

    2016-01-01

    Autoantibodies have been widely used as markers of latent autoimmune diabetes in adults (LADA); however, the specificity and sensitivity of autoantibodies as markers of LADA are weak compared with those found in type 1 diabetes (T1DM). In this study, we aimed to identify other plasma proteins as potential candidates that can be used effectively to determine early stage LADA and type 2 diabetes (T2DM) to facilitate early diagnosis and treatment. These issues were addressed by studying new-onset ‘classic’ T1DM (n = 156), LADA (n = 174), T2DM (n = 195) and healthy cohorts (n = 166). Plasma samples were obtained from the four cohorts. We employed isobaric tag for relative and absolute quantitation (iTRAQ) together with liquid chromatography tandem mass spectrometry (LC-MS) to identify plasma proteins with significant changes in LADA. The changes were validated by Western blot and ELISA analyses. Among the four cohorts, 311 unique proteins were identified in three iTRAQ runs, with 157 present across the three data sets. Among them, 49/311 (16.0%) proteins had significant changes in LADA compared with normal controls, including glycoprotein phospholipase D (GPLD1), which was upregulated in LADA. Western blot and ELISA analyses showed that GPLD1 levels were higher in both LADA and T1DM cohorts than in both T2DM and healthy cohorts, while there were no significant differences in the plasma concentrations of GPLD1 between the LADA and T1DM cohorts. GPLD1 is implicated as a potential candidate plasma protein for determining early stage LADA and T2DM. PMID:27351175

  10. Prognostic Significance of the European LeukemiaNet Standardized System for Reporting Cytogenetic and Molecular Alterations in Adults With Acute Myeloid Leukemia

    PubMed Central

    Mrózek, Krzysztof; Marcucci, Guido; Nicolet, Deedra; Maharry, Kati S.; Becker, Heiko; Whitman, Susan P.; Metzeler, Klaus H.; Schwind, Sebastian; Wu, Yue-Zhong; Kohlschmidt, Jessica; Pettenati, Mark J.; Heerema, Nyla A.; Block, AnneMarie W.; Patil, Shivanand R.; Baer, Maria R.; Kolitz, Jonathan E.; Moore, Joseph O.; Carroll, Andrew J.; Stone, Richard M.; Larson, Richard A.; Bloomfield, Clara D.

    2012-01-01

    Purpose To evaluate the prognostic significance of the international European LeukemiaNet (ELN) guidelines for reporting genetic alterations in acute myeloid leukemia (AML). Patients and Methods We analyzed 1,550 adults with primary AML, treated on Cancer and Leukemia Group B first-line trials, who had pretreatment cytogenetics and, for cytogenetically normal patients, mutational status of NPM1, CEBPA, and FLT3 available. We compared complete remission (CR) rates, disease-free survival (DFS), and overall survival (OS) among patients classified into the four ELN genetic groups (favorable, intermediate-I, intermediate-II, adverse) separately for 818 younger (age < 60 years) and 732 older (age ≥ 60 years) patients. Results The percentages of younger versus older patients in the favorable (41% v 20%; P < .001), intermediate-II (19% v 30%; P < .001), and adverse (22% v 31%; P < .001) genetic groups differed. The favorable group had the best and the adverse group the worst CR rates, DFS, and OS in both age groups. Both intermediate groups had significantly worse outcomes than the favorable but better than the adverse group. Intermediate-I and intermediate-II groups in older patients had similar outcomes, whereas the intermediate-II group in younger patients had better OS but not better CR rates or DFS than the intermediate-I group. The prognostic significance of ELN classification was confirmed by multivariable analyses. For each ELN group, older patients had worse outcomes than younger patients. Conclusion The ELN classification clearly separates the genetic groups by outcome, supporting its use for risk stratification in clinical trials. Because they have different proportions of genetic alterations and outcomes, younger and older patients should be reported separately when using the ELN classification. PMID:22987078

  11. San Rafael Schools Exhibit.

    ERIC Educational Resources Information Center

    San Rafael City Schools, CA.

    The San Rafael City Schools' exhibit which was displayed at the 1983 Marin County Fair (California) is described. The exhibit, entitled "Education - A Real Winner," consisted of 12 display panels illustrating the following aspects of the school system: (1) early history from 1861; (2) present board and administration; (3) present schools and…

  12. A Teaching Aids Exhibition.

    ERIC Educational Resources Information Center

    Mahanja, Salah

    1985-01-01

    Describes an exhibition for the benefit of teachers of English in Arab Primary Schools, which was prepared by third-year students at the Teachers College for Arab Teachers. The exhibition included games, songs, audiovisual aids, crossword puzzles, vocabulary, spelling booklets, preposition aids, and worksheet and lesson planning aids. (SED)

  13. Visitors Center Exhibits

    NASA Technical Reports Server (NTRS)

    1997-01-01

    A child enjoys building his own LEGO model at a play table which was included in the exhibit 'Travel in Space' World Show. The exhibit consisted of 21 displays designed to teach children about flight and space travel from the Wright brothers to future generations of space vehicles.

  14. Communicating Science through Exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.; Harold, J.; Morrow, C.

    It is critically important for the public to better understand the scientific process. Museum exhibitions are an important part of informal science education that can effectively reach public audiences as well as school groups. They provide an important gateway for the public to learn about compelling scientific endeavors. There are many ways for scientists to help develop science exhibitions. The Space Science Institute (SSI) is a national leader in producing traveling science exhibitions and their associated educational programming (i.e. interactive websites, educator workshops, public talks, instructional materials). Two of its exhibitions, Space Weather Center and MarsQuest, are currently on tour. Another exhibition, Alien Earths, is in development. The Space Weather Center was developed in partnership with various research missions at NASA's Goddard Space Flight Center. MarsQuest is a 5000 square-foot traveling exhibition. The exhibit's second 3-year tour began this January at the Detroit Science Center. It is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and to learn more about their own planet in the process. The 3,000 square-foot traveling exhibition, called Alien Earths, will bring origins-related research and discoveries to students and the American public. Alien Earths has four interrelated exhibit areas: Our Place in Space, Star Birth, PlanetQuest, and Search for Life. Exhibit visitors will explore the awesome events surrounding the birth of stars and planets; they will join scientists in the hunt for planets outside our solar system including those that may be in ``habitable zones'' around other stars; and finally they will be able to learn about how scientists are looking for signs of life beyond Earth. Besides the exhibits, SSI is also developing interactive web sites based on exhibit themes. New technologies are transforming the Web from a static medium to an interactive environment with tremendous

  15. 76 FR 52378 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ... Featuring Selections From the National Museum of History, Taiwan and the Arthur M. Sackler Gallery... Jade Featuring Selections from the National Museum of History, Taiwan and the Arthur M. Sackler Gallery... Art, San Antonio, TX, from on or about October 1, 2011, until on or about February 19, 2012, and...

  16. 76 FR 68808 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  17. 78 FR 25337 - Culturally Significant Object Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-30

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  18. 77 FR 31909 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-30

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  19. 75 FR 6079 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No. 236......

  20. 78 FR 50137 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  1. 77 FR 18295 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-27

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  2. 76 FR 61472 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-04

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  3. 77 FR 31420 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  4. 78 FR 7849 - Culturally Significant Objects Imported for Exhibition

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  5. New Hurricane Exhibit

    NASA Technical Reports Server (NTRS)

    2007-01-01

    A new exhibit in StenniSphere depicting NASA's role in hurricane prediction and research and SSC's role in helping the region recover from Hurricane Katrina. The cyclone-shaped exhibit focuses on the effects of the Aug. 29, 2005 storm and outlines how NASA is working to improve weather forecasting. Through photos, 3-D models and digital animations, the exhibit tells the story of what happened inside the storm and how NASA's scientific research can increase the accuracy of hurricane tracking and modeling.

  6. Consumption of a healthy dietary pattern results in significant reductions in C-reactive protein levels in adults: a meta-analysis.

    PubMed

    Neale, E P; Batterham, M J; Tapsell, L C

    2016-05-01

    Consumption of healthy dietary patterns has been associated with reduced risk of cardiovascular disease and metabolic syndrome. Dietary intervention targets disease prevention, so studies increasingly use biomarkers of underlying inflammation and metabolic syndrome progression to examine the diet-health relationship. The extent to which these biomarkers contribute to the body of evidence on healthy dietary patterns is unknown. The aim of this meta-analysis was to determine the effect of healthy dietary patterns on biomarkers associated with adiposity, insulin resistance, and inflammation in adults. A systematic search of Scopus, PubMed, Web of Science, and Cochrane Central Register of Controlled Trials (all years to April 2015) was conducted. Inclusion criteria were randomized controlled trials; effects of dietary patterns assessed on C-reactive protein (CRP), total adiponectin, high-molecular-weight adiponectin, tumor necrosis factor-α, adiponectin:leptin, resistin, or retinol binding protein 4. Random effects meta-analyses were conducted to assess the weighted mean differences in change or final mean values for each outcome. Seventeen studies were included in the review. These reflected research on dietary patterns associated with the Mediterranean diet, Nordic diet, Tibetan diet, and the Dietary Approaches to Stop Hypertension diet. Consumption of a healthy dietary pattern was associated with significant reductions in CRP (weighted mean difference, -0.75 [-1.16, -0.35]; P = .0003). Non-significant changes were found for all other biomarkers. This analysis found evidence for favorable effects of healthy dietary patterns on CRP, with limited evidence for other biomarkers. Future research should include additional randomized controlled trials incorporating a greater range of dietary patterns and biomarkers. PMID:27101757

  7. Variability in cardiac MR measurement of left ventricular ejection fraction, volumes and mass in healthy adults: defining a significant change at 1 year

    PubMed Central

    Edwards, N C; Chue, C D; Taylor, R J; Ferro, C J; Townend, J N; Steeds, R P

    2015-01-01

    Objective: Variability in the measurement of left ventricular (LV) parameters in cardiovascular imaging has typically been assessed over a short time interval, but clinicians most commonly compare results from studies performed a year apart. To account for variation in technical, procedural and biological factors over this time frame, we quantified the within-subject changes in LV volumes, LV mass (LVM) and LV ejection fraction (EF) in a well-defined cohort of healthy adults at 12 months. Methods: Cardiac MR (CMR) was performed in 42 healthy control subjects at baseline and at 1 year (1.5 T Magnetom® Avanto; Siemens Healthcare, Erlangen, Germany). Analysis of steady-state free precession images was performed manually offline (Argus software; Siemens Healthcare) for assessment of LV volumes, LVM and EF by a single blinded observer. A random subset of 10 participants also underwent repeat imaging within 7 days to determine short-term interstudy reproducibility. Results: There were no significant changes in any LV parameter on repeat CMR at 12 months. The short-term interstudy biases were not significantly different from the long-term changes observed at 1 year. The smallest detectable change (SDC) for LVEF, end-diastolic volume, end-systolic volume and LVM that could be recognized with 95% confidence were 6%, 13 ml, 7 ml and 6 g, respectively. Conclusion: The variability in CMR-derived LV measures arising from technical, procedural and biological factors remains minimal at 12 months. Thus, for patients undergoing repeat annual assessment by CMR, even small differences in LV function, size and LVM (which are greater than the SDC) may be attributed to disease-related factors. Advances in knowledge: The reproducibility and reliability of CMR data at 12 months is excellent allowing clinicians to be confident that even small changes in LV structure and function over this time frame are real. PMID:25710361

  8. Communicating Science through Exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, Paul

    2005-04-01

    It is critically important for the public to better understand the scientific process. Museum exhibitions are an important part of informal science education that can effectively reach public audiences as well as school groups. They provide an important gateway for the public to learn about compelling scientific endeavors. Science exhibitions also provide a marvelous opportunity for scientists to become engaged in the exhibit development process. The Space Science Institute (SSI) is a national leader in producing traveling science exhibitions and their associated educational programming (i.e. interactive websites, educator workshops, public talks, instructional materials). The focus of this presentation will be on two of its exhibit projects: MarsQuest (on tour for four years) and Alien Earths (its tour began early in 2005). MarsQuest is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and to learn more about their own planet in the process. Alien Earths will bring origins-related research and discoveries to students and the American public. It has four interrelated exhibit areas: Our Place in Space, Star Birth, Planet Quest, and Search for Life. Exhibit visitors will explore the awesome events surrounding the birth of stars and planets; they will join scientists in the hunt for planets outside our solar system including those that may be in ``habitable zones'' around other stars; and finally they will be able to learn about how scientists are looking for signs of life beyond Earth. SSI is also developing interactive web sites based on exhibit themes. New technologies are transforming the Web from a static medium to an interactive environment with tremendous potential for informal education and inquiry-based investigations. This talk will focus on the role informal science projects play in effectively communicating science to a broad, public audience.

  9. Test Control Center exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  10. Swamp to Space exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The menacing-looking alligator is really harmless. It is one of the realistic props to help convince visitors that the feel of the swamp is real in StenniSphere's Swamp to Space exhibit at John C. Stennis Space Center in Hancock County, Miss. The historical section of the Swamp to Space exhibit tells the story of why and how Stennis Space Center came to be. It also pays tribute to the families who moved their homes to make way for the space age in Mississippi.

  11. 1989 Architectural Exhibition Winners.

    ERIC Educational Resources Information Center

    School Business Affairs, 1990

    1990-01-01

    Winners of the 1989 Architectural Exhibition sponsored annually by the ASBO International's School Facilities Research Committee include the Brevard Performing Arts Center (Melbourne, Florida), the Capital High School (Santa Fe, New Mexico), Gage Elementary School (Rochester, Minnesota), the Lakewood (Ohio) High School Natatorium, and three other…

  12. Exhibitions in Sight

    ERIC Educational Resources Information Center

    Wasserman, Burton

    1978-01-01

    During this past year a vast number of art shows have been exhibited across the United States. Their most striking features were their range and diversity. Here are some comments on Ben Shahn's paintings and photography focusing on social realism, some works by the Polish Constructivists, interested in redefining form in relation to space, the…

  13. Skylab Exhibit Ribbon Cutting

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A metal strap became tangled over one of the folded solar array panels when Skylab lost its micro meteoroid shield during its launch. Cutters like the ones used to free the solar array were used to cut the ribbon opening to the public a new full-scale Skylab cluster exhibit at the Alabama Space and Rocket Center in Huntsville, Alabama. Wielding the cutters are (left to right): Alabama Senator James B. Allen; Marshall Space Flight Center director, Dr. William R. Lucas, Huntsville Mayor, Joe Davis; Madison County Commission Chairman, James Record (standing behind Mayor Davis); and chairman of the Alabama Space Science Exhibit Commission, Jack Giles. Astronauts Conrad and Kerwin used the same type of tool in Earth orbit to cut the aluminum strap which jammed the Skylab solar array.

  14. An Exploration of the Significance of Writing Self-Perception for Non-Traditional Adult English Language Learners: Three Case-Studies

    ERIC Educational Resources Information Center

    Correa, Carolina T.

    2009-01-01

    In 2005, the U. S. Department of Education estimated that 44% of the 3 million students enrolled in non-traditional, that is, non-academic, adult education programs were English language learners. Yet, because of the overt focus that tends to be placed on oral communication, little has been done to document how these learners might view themselves…

  15. Maurice Gee's Brilliant Borrowings of Maurice Gee and Significant Others: Realism and Postmodernism in Gee's Books for Children and Adults

    ERIC Educational Resources Information Center

    van Rij, Vivien

    2013-01-01

    This paper examines the work of one of New Zealand's most acclaimed writers, Maurice Gee, and the use of his children's fiction as an experimental ground for postmodernist techniques further developed in his writing for adults. In particular, it considers Gee's borrowings of his own and others' non-fictional and fictional…

  16. Starship 2040 Exhibit

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This photograph shows Justin Varnadore, son of a Marshall TV employee, at the controls of one of the many displays within the Starship 2040 exhibit on display at Joe Davis Stadium in Huntsville, Alabama. Developed by the Space Transportation Directorate at Marshall Space Flight Center (MSFC), the Starship 2040 exhibit is housed in a 48-ft (14.6-m) tractor and trailer rig, permitting it to travel around the Nation, demonstrating NASA's vision of what commercial spaceflight might be like 40 years from now. All the irnovations suggested aboard the exhibit (automated vehicle health monitoring systems, high-energy propulsion drive, navigational aids, and emergency and safety systems) are based on concepts and technologies now being studied at NASA Centers and partner institutions around the Nation. NASA is the Nation's premier agency for development of the space transportation system, including future-generation reusable launch vehicles. Such systems, the keys to a 'real' Starship 2040, require revolutionary advances in critical aerospace technologies, from thermal, magnetic, chemical, and propellantless propulsion systems to new energy sources such as space solar power or antimatter propulsion. These and other advances are now being studied, developed, and tested at NASA field centers and partner institutions all over the Nation.

  17. Online Exhibits & Concept Maps

    NASA Astrophysics Data System (ADS)

    Douma, M.

    2009-12-01

    Presenting the complexity of geosciences to the public via the Internet poses a number of challenges. For example, utilizing various - and sometimes redundant - Web 2.0 tools can quickly devour limited time. Do you tweet? Do you write press releases? Do you create an exhibit or concept map? The presentation will provide participants with a context for utilizing Web 2.0 tools by briefly highlighting methods of online scientific communication across several dimensions. It will address issues of: * breadth and depth (e.g. from narrow topics to well-rounded views), * presentation methods (e.g. from text to multimedia, from momentary to enduring), * sources and audiences (e.g. for experts or for the public, content developed by producers to that developed by users), * content display (e.g. from linear to non-linear, from instructive to entertaining), * barriers to entry (e.g. from an incumbent advantage to neophyte accessible, from amateur to professional), * cost and reach (e.g. from cheap to expensive), and * impact (e.g. the amount learned, from anonymity to brand awareness). Against this backdrop, the presentation will provide an overview of two methods of online information dissemination, exhibits and concept maps, using the WebExhibits online museum (www.webexhibits.org) and SpicyNodes information visualization tool (www.spicynodes.org) as examples, with tips on how geoscientists can use either to communicate their science. Richly interactive online exhibits can serve to engage a large audience, appeal to visitors with multiple learning styles, prompt exploration and discovery, and present a topic’s breadth and depth. WebExhibits, which was among the first online museums, delivers interactive information, virtual experiments, and hands-on activities to the public. While large, multidisciplinary exhibits on topics like “Color Vision and Art” or “Calendars Through the Ages” require teams of scholars, user interface experts, professional writers and editors

  18. Space Shuttle Cockpit exhibit

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Want to sit in the cockpit of the Space Shuttle and watch astronauts work in outer space? At StenniSphere, you can do that and much more. StenniSphere, the visitor center at John C. Stennis Space Center in Hancock County, Miss., presents 14,000-square-feet of interactive exhibits that depict America's race for space as well as a glimpse of the future. StenniSphere is open free of charge from 9 a.m. to 5 p.m. daily.

  19. Sex differences in science museum exhibit attraction

    NASA Astrophysics Data System (ADS)

    Arámbula Greenfield, Teresa

    This study examines the relative attraction of hands-on, interactive science museum exhibits for females and males. Studies have demonstrated that such exhibits can be effective learning experiences for children, with both academic and affective benefits. Other studies have shown that girls and boys do not always experience the same science-related educational opportunities and that, even when they do, they do not necessarily receive the same benefits from them. These early differences can lead to more serious educational and professional disparities later in life. As interactive museum exhibits represent a science experience that is-readily available to both girls and boys, the question arose as to whether they were being used similarly by the two groups as well as by adult women and men. It was found that both girls and boys used all types of exhibits, but that girls were more likely than boys to use puzzles and exhibits focusing on the human body; boys were more likely than girls to use computers and exhibits illustrating physical science principles. However, this was less true of children accompanied by adults (parents) than it was of unaccompanied children on school field trips who roamed the museum more freely.Received: 16 February 1994; Revised: 3 February 1995;

  20. Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid.

    PubMed

    Yves, Plumelle; Stephane, Michel; Rishika, Banydeen; Christine, Delaunay; Gérard, Panelatti

    2015-01-01

    We describe the clinical and biological features of ten patients with a survival superior to ten years (long survival), out of 175 patients diagnosed with Adult T-cell Leukemia/Lymphoma (ATL) in Martinique (1983-2013). There were 5 lymphoma and 5 chronic subtypes. Five of them (3 chronic, 2 lymphoma) had been treated with valproic acid (VA) for neurological disorders developed before or after ATL diagnosis, suggesting a beneficial role for VA as a histone deacetylase inhibitor (HDI) in ATL treatment. Total duration of uninterrupted VA treatment ranged from 8 to 37 years. Overall, the 175 incident ATL cases presented with a median survival of 5.43 months. The five VA-treated (VA(+)) patients presented with longer survival compared to VA treatment-free patients (VA(-)). For chronic subtypes, survival periods were of 213 months for 3 VA(+) patients and of 33 months for 11 VA(-) patients (p = 0.023). For lymphoma subtypes, survival periods were of 144 months for 2 VA(+) patients versus 6 months for 49 VA(-) patients (p = 0.0046). ATL cases with skin lesions, particularly lymphoma subtypes, had a longer survival (13.96 months) compared to those without skin lesions (6.06 months, p = 0.002). Eight out of the 10 patients presenting with long survival had skin lesions. PMID:26199759

  1. Characteristics of Adult T-Cell Leukemia/Lymphoma Patients with Long Survival: Prognostic Significance of Skin Lesions and Possible Beneficial Role of Valproic Acid

    PubMed Central

    Yves, Plumelle; Stephane, Michel; Rishika, Banydeen; Christine, Delaunay; Gérard, Panelatti

    2015-01-01

    We describe the clinical and biological features of ten patients with a survival superior to ten years (long survival), out of 175 patients diagnosed with Adult T-cell Leukemia/Lymphoma (ATL) in Martinique (1983–2013). There were 5 lymphoma and 5 chronic subtypes. Five of them (3 chronic, 2 lymphoma) had been treated with valproic acid (VA) for neurological disorders developed before or after ATL diagnosis, suggesting a beneficial role for VA as a histone deacetylase inhibitor (HDI) in ATL treatment. Total duration of uninterrupted VA treatment ranged from 8 to 37 years. Overall, the 175 incident ATL cases presented with a median survival of 5.43 months. The five VA-treated (VA+) patients presented with longer survival compared to VA treatment-free patients (VA−). For chronic subtypes, survival periods were of 213 months for 3 VA+ patients and of 33 months for 11 VA− patients (p = 0.023). For lymphoma subtypes, survival periods were of 144 months for 2 VA+ patients versus 6 months for 49 VA− patients (p = 0.0046). ATL cases with skin lesions, particularly lymphoma subtypes, had a longer survival (13.96 months) compared to those without skin lesions (6.06 months, p = 0.002). Eight out of the 10 patients presenting with long survival had skin lesions. PMID:26199759

  2. Museum Exhibitions: Optimizing Development Using Evaluation

    NASA Astrophysics Data System (ADS)

    Dusenbery, P. B.

    2002-12-01

    The Space Science Institute (SSI) of Boulder, Colorado, has recently developed two museum exhibits called the Space Weather Center and MarsQuest. It is currently planning to develop a third exhibit called InterActive Earth. The Space Weather Center was developed in partnership with various research missions at NASA's Goddard Space Flight Center. The development of these exhibitions included a comprehensive evaluation plan. I will report on the important role evaluation plays in exhibit design and development using MarsQuest and InterActive Earth as models. The centerpiece of SSI's Mars Education Program is the 5,000-square-foot traveling exhibition, MarsQuest: Exploring the Red Planet, which was developed with support from the National Science Foundation (NSF), NASA, and several corporate donors. The MarsQuest exhibit is nearing the end of a highly successful, fully-booked three-year tour. The Institute plans to send an enhanced and updated MarsQuest on a second three-year tour and is also developing Destination: Mars, a mini-version of MarsQuest designed for smaller venues. They are designed to inspire and empower participants to extend the excitement and science content of the exhibitions into classrooms and museum-based education programs in an ongoing fashion. The centerpiece of the InterActive Earth project is a traveling exhibit that will cover about 4,000 square feet. The major goal of the proposed exhibit is to introduce students and the public to the complexity of the interconnections in the Earth system, and thereby, to inspire them to better understand planet Earth. Evaluation must be an integral part of the exhibition development process. For MarsQuest, a 3-phase evaluation (front end, formative and summative) was conducted by Randi Korn and Associates in close association with the development team. Sampling procedures for all three evaluation phases ensured the participation of all audiences, including family groups, students, and adults. Each phase of

  3. Enhancing the passing moments: An educational criticism of family visits to an early childhood science exhibition

    NASA Astrophysics Data System (ADS)

    Munroe, Elizabeth Ann

    This educational criticism describes and interprets the nature of family visits to an early childhood science exhibition, Working Wonders, at The Science Centre in Calgary, Alberta. The specific exhibits are described and features that contributed to exhibit popularity are examined. Examples of visitors' interactions with each exhibit are given. The visit experiences of four families are described in detail and analyzed. Typical family visitors' reactions, expectations, and experiences are summarized. Because one of the mutual expectations of the granting agency, The Science Centre, and the adult visitors was that a visit to the exhibition would be educational, the family visits are examined for instances of learning and analyzed to determine the factors that influenced the learning. Constructivism forms the basis for understanding the process of learning during family visits. The analysis is supported by reference to research from the fields of museum studies, education, and environmental design. The analysis of the educational significance and potential of family visits to an early childhood exhibition leads to the conclusion that specific features may facilitate learning in such an environment. Those features are represented in a set of guidelines for the development and evaluation of early childhood exhibitions. The guidelines suggest attention must be given to the ambience of the space, the general layout of the space, the exhibits, the copy and graphics, additional programs and information, the subtle influences of the building and the staff, and the learning processes of young children, adults, and intergenerational groups. The guidelines suggest specific issues to consider to develop a space that is stimulating and memorable, responsive to the needs of the two distinct visitor groups (young children and adults), and conducive to learning.

  4. Early Hospital Mortality among Adult Trauma Patients Significantly Declined between 1998-2011: Three Single-Centre Cohorts from Mumbai, India

    PubMed Central

    Gerdin, Martin; Roy, Nobhojit; Dharap, Satish; Kumar, Vineet; Khajanchi, Monty; Tomson, Göran; Tsai, Li Felländer; Petzold, Max; von Schreeb, Johan

    2014-01-01

    Background Traumatic injury causes more than five million deaths each year of which about 90% occur in low- and middle-income countries (LMIC). Hospital trauma mortality has been significantly reduced in high-income countries, but to what extent similar results have been achieved in LMIC has not been studied in detail. Here, we assessed if early hospital mortality in patients with trauma has changed over time in an urban lower middle-income setting. Methods We conducted a retrospective study of patients admitted due to trauma in 1998, 2002, and 2011 to a large public hospital in Mumbai, India. Our outcome measure was early hospital mortality, defined as death between admission and 24-hours. We used multivariate logistic regression to assess the association between time and early hospital mortality, adjusting for patient case-mix. Injury severity was quantified using International Classification of Diseases-derived Injury Severity Score (ICISS). Major trauma was defined as ICISS<0.90. Results We analysed data on 4189 patients out of which 86.5% were males. A majority of patients were between 15 and 55 years old and 36.5% had major trauma. Overall early hospital mortality was 8.9% in 1998, 6.0% in 2002, and 8.1% in 2011. Among major trauma patients, early hospital mortality was 13.4%, in 1998, 11.3% in 2002, and 10.9% in 2011. Compared to trauma patients admitted in 1998, those admitted in 2011 had lower odds for early hospital mortality (OR = 0.56, 95% CI = 0.41–0.76) including those with major trauma (OR = 0.57, 95% CI = 0.41–0.78). Conclusions We observed a significant reduction in early hospital mortality among patients with major trauma between 1998 and 2011. Improved survival was evident only after we adjusted for patient case-mix. This finding highlights the importance of risk-adjustment when studying longitudinal mortality trends. PMID:24594775

  5. Splenic lymphocytes of adult Xenopus respond differentially to PMA in vitro by either dying or dividing: significance for cancer resistance in this species.

    PubMed

    Taylor, S J; Johnson, R O; Ruben, L N; Clothier, R H

    2003-01-01

    Wild-type populations of amphibians, unlike mammalians, appear to be resistant to spontaneous and chemically induced neoplasms. Few true cancers have been reported for non-isogeneic members of Xenopus laevis, despite their widespread use in laboratories around the world. Injection of even the most powerful direct mammalian oncogens e.g. N-methyl N-nitrosourea, that depleted specific populations of T lymphocytes, did not induce cancer. Phorbol diesters, e.g. PMA, are mitogens and apoptogens in both amphibian, and mammalian immunocytes. In mammalian cells, regulation of the cell cycle and of apoptosis are often intimately linked, however, a disjunction in time between early apoptosis and later cell cycling, has been observed with PMA-treated Xenopus splenocytes. Thus, a particular difference between amphibians and mammals may be the requirement to enter the cell cycle before a progression to death by apoptosis. This hypothesis was tested here using dual staining flow cytometry. Xenopus laevis splenocytes were cultured for 8, 24 and 48 hours with phorbol 12-myristate 13-acetate (PMA), previously shown to be mitogenic and apoptotic with mature Xenopus lymphocytes. The cells were stained with FITC-conjugated Annexin V or with FITC-labeled deoxyuridine triphosphates (FITC-dUTP) to assay for the apoptotic markers phosphotidylserine or DNA strand breaks respectively. Phycoerythrin (PE)-conjugated anti-human proliferating cell nuclear antigen (PE-PCNA) was used as a cell cycle marker that is present during the entire cell cycle. Propidium iodide (PI) binds DNA and was used to assay for late stage apoptosis, as well as to assess DNA content. Significantly higher levels of apoptosis develop rapidly in PMA-exposed splenocytes and are maintained at 24 hours, declining by 48 hours. Cells expressing PCNA or incorporating PI in excess of the normal genomic level were found by 48 hours following PMA exposure. The absence of any significant rise in a small (<5%) dual staining cell

  6. Randomised, single-masked non-inferiority trial of femtosecond laser-assisted versus manual phacoemulsification cataract surgery for adults with visually significant cataract: the FACT trial protocol

    PubMed Central

    Day, Alexander C; Burr, Jennifer M; Bunce, Catey; Doré, Caroline J; Sylvestre, Yvonne; Wormald, Richard P L; Round, Jeff; McCudden, Victoria; Rubin, Gary; Wilkins, Mark R

    2015-01-01

    Introduction Cataract is one of the leading causes of low vision in the westernised world, and cataract surgery is one of the most commonly performed operations. Laser platforms for cataract surgery are now available, the anticipated advantages of which are broad and may include better visual outcomes through greater precision and reproducibility, and improved safety. FACT is a randomised single masked non-inferiority trial to establish whether laser-assisted cataract surgery is as good as or better than standard manual phacoemulsification. Methods and analysis 808 patients aged 18 years and over with visually significant cataract will be randomised to manual phacoemulsification cataract surgery (standard care) or laser-assisted cataract surgery (intervention arm). Outcomes will be measured at 3 and 12 months after surgery. The primary clinical outcome is uncorrected distance visual acuity (UDVA, logMAR) at 3 months in the study eye recorded by an observer masked to the trial group. Secondary outcomes include UDVA at 12 months, corrected distance visual acuity at 3 and 12 months, complications, endothelial cell loss, patient-reported outcome measures and a health economic analysis conforming to National Institute for Health and Care Excellence standards. Ethics and dissemination Research Ethics Committee Approval was obtained on 6 February 2015, ref: 14/LO/1937. Current protocol: v2.0 (08/04/2015). Study findings will be published in peer-reviewed journals. Trial registration number ISRCTN: 77602616. PMID:26614627

  7. Environmental enrichment for a mixed-species nocturnal mammal exhibit.

    PubMed

    Clark, Fay E; Melfi, Vicky A

    2012-01-01

    Environmental enrichment (EE) is an integral aspect of modern zoo animal management but, empirical evaluation of it is biased toward species housed in single-species groups. Nocturnal houses, where several nocturnal species are housed together, are particularly overlooked. This study investigated whether three species (nine-banded armadillos, Dasypus novemcinctus; Senegal bush babies, Galago senegalensis; two-toed sloths, Choloepus didactylus) in the nocturnal house at Paignton Zoo Environmental Park, UK could be enriched using food-based and sensory EE. Subjects were an adult male and female of each species. EE was deemed effective if it promoted target species-typical behaviors, behavioral diversity, and increased use of enriched exhibit zones. Results from generalized linear mixed models demonstrated that food-based EE elicited the most positive behavioral effects across species. One set of food-based EEs (Kong®, termite mound and hanging food) presented together was associated with a significant increase in species-typical behaviors, increased behavioral diversity, and increased use of enriched exhibit zones in armadillos and bush babies. Although one type of sensory EE (scented pine cones) increased overall exhibit use in all species, the other (rainforest sounds) was linked to a significant decrease in species-typical behavior in bush babies and sloths. There were no intra or interspecies conflicts over EE, and commensalism occurred between armadillos and bush babies. Our data demonstrate that simple food-based and sensory EE can promote positive behavioral changes in a mixed-species nocturnal mammal exhibit. We suggest that both food and sensory EE presented concurrently will maximize opportunities for naturalistic activity in all species. PMID:21387395

  8. Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastroesophageal reflux and antral gastritis: eradication results to no significant clinical improvement

    PubMed Central

    Xinias, Ioannis; Maris, Theophanis; Mavroudi, Antigoni; Panteliadis, Christos; Vandenplas, Yvan

    2013-01-01

    The relationship between Helicobacter pylori (Hp) gastritis and gastroesophageal reflux disease (GERD) remains controversial. The aim was to investigate the association between Hp infection and gastroesophageal reflux (GER) and the impact of Hp eradication on esophageal acid exposure and motility in adolescents and young adults with Hp gastritis and GERD. Sixty-four patients with symptoms suggestive for GERD, of which 40 Hp-positive (group A) and 24 Hp-negative (group B), underwent endoscopy-biopsy, esophageal manometry and 24-hour pH-metry. All group A patients received eradication treatment and were re-evaluated six months later again with 24-hour pH-metry, esophageal manometry, endoscopy-biopsy and clinical assessment. At inclusion, there were no significant differences between the two groups regarding sex, age, grade of endoscopic esophagitis, manometric and pH-metry findings. All Hp-positive patients had an antral predominant gastritis. Eradication of Hp was successful in all patients, and gastritis and esophagitis were healed in all patients. The mean lower esophageal sphincter pressure (LESP) increased significantly from 11.25 mmHg before to 11.71 mmHg after eradication (P<0.05). A significant decrease in reflux index was observed (mean RI 6.02% before versus 4.96% after eradication (P<0.05). However clinical symptoms of GER improved not significantly after 6 months follow up. Conclusively, in children and young adults with GER symptoms and GERD, the presence or absence of Hp has no impact on manometric and pH-metric findings. Eradication of Hp infection results in increase in LESP with a consequent decrease in esophageal acid exposure but not significant clinical improvement. PMID:23667732

  9. Traveling Exhibitions: translating current science into effective science exhibitions

    NASA Astrophysics Data System (ADS)

    Dusenbery, P.; Morrow, C.; Harold, J.

    The Space Science Institute (SSI) of Boulder, Colorado has recently developed two museum exhibits called the Space Weather Center and MarsQuest. It is currently planning to develop two other exhibitions called Cosmic Origins and InterActive Earth. Museum exhibitions provide research scientists the opportunity to engage in a number of activities that are vital to the success of earth and space outreach programs. The Space Weather Center was developed in partnership with various research missions at NASA's Goddard Space Flight Center. The focus of the presentation will be on the Institute's MarsQuest exhibition. This project is a 5000 square-foot, 2.5M, traveling exhibition that is now touring the country. The exhibit's 3-year tour is enabling millions of Americans to share in the excitement of the scientific exploration of Mars and learn more about their own planet in the process. The associated planetarium show and education program will also be described, with particular emphasis on workshops to orient host museum staff (e.g. museum educators and docents). The workshops make innovative connections between the exhibitions interactive experiences and lesson plans aligned with the National Science Education Standards. SSI is also developing an interactive web site called MarsQuest On-line. The linkage between the web site, education program and exhibit will be discussed. MarsQuest and SSI's other exhibitions are good models for actively involving scientists and their discoveries to help improve informal science education in the museum community and for forging a stronger connection between formal and informal education.

  10. Gender and Single Nucleotide Polymorphisms in MTHFR, BHMT, SPTLC1, CRBP2, CETP, and SCARB1 Are Significant Predictors of Plasma Homocysteine Normalized by RBC Folate in Healthy Adults123

    PubMed Central

    Clifford, Andrew J.; Chen, Kehui; McWade, Laura; Rincon, Gonzalo; Kim, Seung-Hyun; Holstege, Dirk M.; Owens, Janel E.; Liu, Bitao; Müller, Hans-Georg; Medrano, Juan F.; Fadel, James G.; Moshfegh, Alanna J.; Baer, David J.; Novotny, Janet A.

    2012-01-01

    Using linear regression models, we studied the main and 2-way interaction effects of the predictor variables gender, age, BMI, and 64 folate/vitamin B-12/homocysteine (Hcy)/lipid/cholesterol-related single nucleotide polymorphisms (SNP) on log-transformed plasma Hcy normalized by RBC folate measurements (nHcy) in 373 healthy Caucasian adults (50% women). Variable selection was conducted by stepwise Akaike information criterion or least angle regression and both methods led to the same final model. Significant predictors (where P values were adjusted for false discovery rate) included type of blood sample [whole blood (WB) vs. plasma-depleted WB; P < 0.001] used for folate analysis, gender (P < 0.001), and SNP in genes SPTLC1 (rs11790991; P = 0.040), CRBP2 (rs2118981; P < 0.001), BHMT (rs3733890; P = 0.019), and CETP (rs5882; P = 0.017). Significant 2-way interaction effects included gender × MTHFR (rs1801131; P = 0.012), gender × CRBP2 (rs2118981; P = 0.011), and gender × SCARB1 (rs83882; P = 0.003). The relation of nHcy concentrations with the significant SNP (SPTLC1, BHMT, CETP, CRBP2, MTHFR, and SCARB1) is of interest, especially because we surveyed the main and interaction effects in healthy adults, but it is an important area for future study. As discussed, understanding Hcy and genetic regulation is important, because Hcy may be related to inflammation, obesity, cardiovascular disease, and diabetes mellitus. We conclude that gender and SNP significantly affect nHcy. PMID:22833659

  11. Exhibitions: Facing Outward, Pointing Inward

    ERIC Educational Resources Information Center

    McDonald, Joseph P.

    2007-01-01

    The Coalition of Essential Schools (CES) Exhibitions Project of the early 1990s produced a range of work that continues to inform the practice of using exhibitions as a "360 degree" method of transforming teaching and learning, community connections, school design, and assessment. Among that work was this paper coupling the origins of exhibitions…

  12. Significant Treasures.

    ERIC Educational Resources Information Center

    Andrews, Ian A.

    1999-01-01

    Provides a crossword puzzle with an answer key corresponding to the book entitled "Significant Treasures/Tresors Parlants" that is filled with color and black-and-white prints of paintings and artifacts from 131 museums and art galleries as a sampling of the 2,200 such Canadian institutions. (CMK)

  13. Psychological resources of adults with developmental dyslexia.

    PubMed

    Łockiewicz, Marta; Bogdanowicz, Katarzyna M; Bogdanowicz, Marta

    2014-01-01

    The aim of our study was to describe specific psychological resources of adults with developmental dyslexia and compare them with psychological resources of adults without developmental dyslexia. Potential differences were analyzed in visual-spatial, creative, and motivational abilities. No evidence was found for either creative, or visuospatial superiority in adults with developmental dyslexia. The results suggest, however, that visual-spatial processing of nonverbal material by adults with developmental dyslexia allows them to efficiently execute tasks that are based on sequential material. Moreover, the participants with specific difficulties in reading and writing exhibited a significantly higher level of aspirations than their peers without such difficulties with a comparable level of educational achievement. These results suggest that succeeding in different fields by highly functioning adult dyslexics may depend on personality and motivational factors, rather than cognitive factors. PMID:23462191

  14. Against the Odds Exhibition Opens

    MedlinePlus

    ... the National Institutes of Health in Bethesda, Md. Photo courtesy of Bill Branson NIH Director Dr. Elias ... addresses visitors to the opening of the exhibition. Photo courtesy of Bill Branson Brothers Niko and Theo ...

  15. Against the Odds Exhibition Opens

    MedlinePlus

    ... Bar Home Current Issue Past Issues Special Section Against the Odds Exhibition Opens Past Issues / Spring 2008 ... Research in Bethesda. Photo courtesy of Bill Branson "Against the Odds" is a remarkable story of achievement ...

  16. MarsQuest: A National Traveling Exhibition

    NASA Astrophysics Data System (ADS)

    Lee, S. W.; Dusenbery, P. B.

    1998-09-01

    With the successful landing of Mars Pathfinder and the arrival of Mars Global Surveyor, a new decade of Mars exploration has commenced. MarsQuest, a 5000 square foot traveling exhibition, is being developed to further bring the excitement and discoveries of this "Decade of Mars Exploration" to the public. MarsQuest is partially funded by the Informal Science Education Program of the National Science Foundation and NASA's Office of Space Science. The Space Science Institute (SSI) in Boulder, CO, is leading the project. Scientific and educational advisors from many different universities and government laboratories, most of whom are directly involved in the active and planned Mars missions, will ensure the scientific accuracy, timeliness, and relevance of the key concepts presented in the exhibition and accompanying programs. The traveling exhibit is the primary element of the MarsQuest project. The exhibition experience, carefully keyed to current events in Mars exploration, will transport visitors to the surface of the Red Planet via large murals, dioramas, and numerous interactive displays. There they will have the opportunity to share in the spirit and thrill of exploration, and come to appreciate the similarities and differences between Earth and Mars. A planetarium show, geared to the goals of the MarsQuest project, will be an important sensory addition to the traveling exhibit. The planetarium/star-theater venue presents a unique environment where audience members can literally be surrounded by Mars images. Education and outreach programs comprise the remainder of the MarsQuest project. The goal of these is to make scientific concepts and scientific and engineering processes understandable to students via Mars-inspired curricula. MarsQuest will open in late-1999, traveling to about nine sites throughout the United States and reaching an estimated two to three million children and adults during its planned three-year tour. Mars - coming soon to a museum near

  17. Greenhouse Earth: A Traveling Exhibition

    SciTech Connect

    Booth, W.H.; Caesar, S.

    1992-09-01

    The Franklin Institute Science Museum provided an exhibit entitled the Greenhouse Earth: A Traveling Exhibition. This 3500 square-foot exhibit on global climate change was developed in collaboration with the Association of Science-Technology Centers. The exhibit opened at The Franklin Institute on February 14, 1992, welcoming 291,000 visitors over its three-month stay. During its three-year tour, Greenhouse Earth will travel to ten US cities, reaching two million visitors. Greenhouse Earth aims to deepen public understanding of the scientific issues of global warming and the conservation measures that can be taken to slow its effects. The exhibit features hands-on exhibitry, interactive computer programs and videos, a theater production, a demonstration cart,'' guided tours, and lectures. supplemental educational programs at the Institute included a teachers preview, a symposium on climate change, and a satellite field trip.'' The development of Greenhouse Earth included front-end and formative evaluation procedures. Evaluation includes interviews with visitors, prototypes, and summative surveys for participating museums. During its stay in Philadelphia, Greenhouse Earth was covered by the local and national press, with reviews in print and broadcast media. Greenhouse Earth is the first large-scale museum exhibit to address global climate change.

  18. Neural Correlates of Letter Reversal in Children and Adults

    PubMed Central

    Kalra, Priya; Yee, Debbie; Sinha, Pawan; Gabrieli, John D. E.

    2014-01-01

    Children often make letter reversal errors when first learning to read and write, even for letters whose reversed forms do not appear in normal print. However, the brain basis of such letter reversal in children learning to read is unknown. The present study compared the neuroanatomical correlates (via functional magnetic resonance imaging) and the electrophysiological correlates (via event-related potentials or ERPs) of this phenomenon in children, ages 5–12, relative to young adults. When viewing reversed letters relative to typically oriented letters, adults exhibited widespread occipital, parietal, and temporal lobe activations, including activation in the functionally localized visual word form area (VWFA) in left occipito-temporal cortex. Adults exhibited significantly greater activation than children in all of these regions; children only exhibited such activation in a limited frontal region. Similarly, on the P1 and N170 ERP components, adults exhibited significantly greater differences between typical and reversed letters than children, who failed to exhibit significant differences between typical and reversed letters. These findings indicate that adults distinguish typical and reversed letters in the early stages of specialized brain processing of print, but that children do not recognize this distinction during the early stages of processing. Specialized brain processes responsible for early stages of letter perception that distinguish between typical and reversed letters may develop slowly and remain immature even in older children who no longer produce letter reversals in their writing. PMID:24859328

  19. Considering High-Tech Exhibits?

    ERIC Educational Resources Information Center

    Routman, Emily

    1994-01-01

    Discusses a variety of high-tech exhibit media used in The Living World, an educational facility operated by The Saint Louis Zoo. Considers the strengths and weaknesses of holograms, video, animatronics, video-equipped microscopes, and computer interactives. Computer interactives are treated with special attention. (LZ)

  20. Life satisfaction in young adults 10 or more years after hematopoietic stem cell transplantation for childhood malignant and nonmalignant diseases does not show significant impairment compared with healthy controls: a case-matched study.

    PubMed

    Uderzo, Cornelio; Corti, Paola; Pappalettera, Marco; Baldini, Valentina; Lucchini, Giovanna; Meani, Dario; Rovelli, Attilio

    2012-11-01

    Patients undergoing hematopoietic stem cell transplantation (HSCT) may experience physical and psychological deterioration that impairs their life satisfaction (LS). This study focused on LS in long-term survivors at 10 or more years after HSCT. Fifty-five patients (39 males, median age 25 years) undergoing allogeneic HSCT for childhood malignant (n = 52) or nonmalignant diseases (n = 3) were enrolled. A control group of 98 young adults (59 males, median age 24 years) was considered. A questionnaire with a modified Satisfaction Life Domain Scale was administered. We assessed such domains as education, employment, leisure time, social relationships, and perception of physical status with a 30-item questionnaire. To investigate the association between the domains and the probability of diminished LS, we performed a logistical procedure using the maximum likelihood method. Predictive factors of LS were adjusted for sociodemographic variables. In the multivariate analysis, the participant's level of LS was not significantly correlated with sociodemographic factors or with HSCT status. The same analysis showed a slight trend in favor of the control group (P = .06) for body perception. Our data suggest that the patients who undergo HSCT in childhood have no significant difference in long-term LS compared with healthy controls. PMID:22766222

  1. "I Remember the Whole Board Being Full of Different Calculations and Trying to Make Some Sense of It." The Influence of Significant Moments in Adult Numeracy Teachers' Own Learning Experiences on Their Teaching Practice

    ERIC Educational Resources Information Center

    Brooks, Carolyn

    2014-01-01

    In researching how adult numeracy teachers actively motivate and enable learners to apply the numeracy skills they learn to their own real life practices, a case study of two adult numeracy teachers and their learner groups was undertaken. This paper compares the teachers' contrasting personal experiences of mathematics learning to consider how…

  2. Longwall - USA: International exhibition & conference

    SciTech Connect

    1996-12-31

    The Longwall-USA International Exhibition and Conference was held June 4-6, 1996 in Pittsburgh, PA. Seventeen papers are included in the proceedings that covered such topics as health and safety, development of gate roads, telemetry monitoring systems, fires, longwall miners, roof support technologies, dust control, moving car bunker systems, reducing longwall noise, vibration of longwall equipment, and the USBM`s strategic structures testing laboratory. A separate abstract with indexing was prepared for each paper for inclusion in the Energy Science and Technology Database.

  3. Children do not exhibit ambiguity aversion despite intact familiarity bias

    PubMed Central

    Li, Rosa; Brannon, Elizabeth M.; Huettel, Scott A.

    2015-01-01

    The phenomenon of ambiguity aversion, in which risky gambles with known probabilities are preferred over ambiguous gambles with unknown probabilities, has been thoroughly documented in adults but never measured in children. Here, we use two distinct tasks to investigate ambiguity preferences of children (8- to 9-year-olds) and a comparison group of adults (19- to 27-year-olds). Across three separate measures, we found evidence for significant ambiguity aversion in adults but not in children and for greater ambiguity aversion in adults compared to children. As ambiguity aversion in adults has been theorized to result from a preference to bet on the known and avoid the unfamiliar, we separately measured familiarity bias and found that children, like adults, are biased towards the familiar. Our findings indicate that ambiguity aversion emerges across the course of development between childhood and adolescence, while a familiarity bias is already present in childhood. PMID:25601848

  4. Collaborative virtual environments art exhibition

    NASA Astrophysics Data System (ADS)

    Dolinsky, Margaret; Anstey, Josephine; Pape, Dave E.; Aguilera, Julieta C.; Kostis, Helen-Nicole; Tsoupikova, Daria

    2005-03-01

    This panel presentation will exhibit artwork developed in CAVEs and discuss how art methodologies enhance the science of VR through collaboration, interaction and aesthetics. Artists and scientists work alongside one another to expand scientific research and artistic expression and are motivated by exhibiting collaborative virtual environments. Looking towards the arts, such as painting and sculpture, computer graphics captures a visual tradition. Virtual reality expands this tradition to not only what we face, but to what surrounds us and even what responds to our body and its gestures. Art making that once was isolated to the static frame and an optimal point of view is now out and about, in fully immersive mode within CAVEs. Art knowledge is a guide to how the aesthetics of 2D and 3D worlds affect, transform, and influence the social, intellectual and physical condition of the human body through attention to psychology, spiritual thinking, education, and cognition. The psychological interacts with the physical in the virtual in such a way that each facilitates, enhances and extends the other, culminating in a "go together" world. Attention to sharing art experience across high-speed networks introduces a dimension of liveliness and aliveness when we "become virtual" in real time with others.

  5. Crows spontaneously exhibit analogical reasoning.

    PubMed

    Smirnova, Anna; Zorina, Zoya; Obozova, Tanya; Wasserman, Edward

    2015-01-19

    Analogical reasoning is vital to advanced cognition and behavioral adaptation. Many theorists deem analogical thinking to be uniquely human and to be foundational to categorization, creative problem solving, and scientific discovery. Comparative psychologists have long been interested in the species generality of analogical reasoning, but they initially found it difficult to obtain empirical support for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]). Researchers have since mustered considerable evidence and argument that relational matching-to-sample (RMTS) effectively captures the essence of analogy, in which the relevant logical arguments are presented visually. In RMTS, choice of test pair BB would be correct if the sample pair were AA, whereas choice of test pair EF would be correct if the sample pair were CD. Critically, no items in the correct test pair physically match items in the sample pair, thus demanding that only relational sameness or differentness is available to support accurate choice responding. Initial evidence suggested that only humans and apes can successfully learn RMTS with pairs of sample and test items; however, monkeys have subsequently done so. Here, we report that crows too exhibit relational matching behavior. Even more importantly, crows spontaneously display relational responding without ever having been trained on RMTS; they had only been trained on identity matching-to-sample (IMTS). Such robust and uninstructed relational matching behavior represents the most convincing evidence yet of analogical reasoning in a nonprimate species, as apes alone have spontaneously exhibited RMTS behavior after only IMTS training. PMID:25532894

  6. Cystamine preparations exhibit anticoagulant activity.

    PubMed

    Aleman, Maria M; Holle, Lori A; Stember, Katherine G; Devette, Christa I; Monroe, Dougald M; Wolberg, Alisa S

    2015-01-01

    Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl)-lysyl crosslinks between proteins. Cystamine blocks transglutaminase activity and is used in vitro in human samples and in vivo in mice and rats in studies of coagulation, immune dysfunction, and inflammatory disease. These studies have suggested cystamine blocks fibrin crosslinking and has anti-inflammatory effects, implicating transglutaminase activity in the pathogenesis of several diseases. We measured the effects of cystamine on fibrin crosslinking, tissue factor-triggered plasma clot formation and thrombin generation, and coagulation factor enzymatic activity. At concentrations that blocked fibrin crosslinking, cystamine also inhibited plasma clot formation and reduced thrombin generation. Cystamine inhibited the amidolytic activity of coagulation factor XI and thrombin towards chromogenic substrates. These findings demonstrate that cystamine exhibits anticoagulant activity during coagulation. Given the close relationship between coagulation and inflammation, these findings suggest prior studies that used cystamine to implicate transglutaminase activity in disease pathogenesis warrant re-examination. PMID:25915545

  7. Cystamine Preparations Exhibit Anticoagulant Activity

    PubMed Central

    Aleman, Maria M.; Holle, Lori A.; Stember, Katherine G.; Devette, Christa I.; Monroe, Dougald M.; Wolberg, Alisa S.

    2015-01-01

    Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl)-lysyl crosslinks between proteins. Cystamine blocks transglutaminase activity and is used in vitro in human samples and in vivo in mice and rats in studies of coagulation, immune dysfunction, and inflammatory disease. These studies have suggested cystamine blocks fibrin crosslinking and has anti-inflammatory effects, implicating transglutaminase activity in the pathogenesis of several diseases. We measured the effects of cystamine on fibrin crosslinking, tissue factor-triggered plasma clot formation and thrombin generation, and coagulation factor enzymatic activity. At concentrations that blocked fibrin crosslinking, cystamine also inhibited plasma clot formation and reduced thrombin generation. Cystamine inhibited the amidolytic activity of coagulation factor XI and thrombin towards chromogenic substrates. These findings demonstrate that cystamine exhibits anticoagulant activity during coagulation. Given the close relationship between coagulation and inflammation, these findings suggest prior studies that used cystamine to implicate transglutaminase activity in disease pathogenesis warrant re-examination. PMID:25915545

  8. How to create an effective scientific exhibit: analysis of award-winning exhibits from the 1998 RSNA meeting.

    PubMed

    Choi, J R; Kruskal, J B; Rosen, M P; Davis, R B

    2000-01-01

    Although the most important component of an effective scientific exhibit is content, the way in which an exhibit is constructed can greatly influence its overall effectiveness. Choice of format should be determined by carefully analyzing the purpose of one's exhibit, expected audience, and data at hand, as well as type of meeting and funding. Depending on the type of data to be presented and available equipment and budget, the most appropriate style for a scientific exhibit may be a traditional mat board, computer-generated tiles or large-print backboard panel, traditional mat board with viewbox exhibit, matted transparency tiles with viewbox exhibit, or computer-generated large-film display. The authors analyzed 993 of 1, 041 (95.4%) scientific exhibits on display at the 84th RSNA Scientific Assembly and Annual Meeting and categorized each exhibit according to the following characteristics: display type and size, color scheme, display font size, and graphic styles. These characteristics were then correlated with scientific exhibit and design awards as well as invitations for submission to RadioGraphics. Chance of winning an award or being asked to publish the presentation in RadioGraphics was significantly increased for viewbox exhibits (compared with backboard panel exhibits) and for larger exhibits (compared with smaller exhibits). PMID:10903695

  9. Bumblebees exhibit the memory spacing effect

    NASA Astrophysics Data System (ADS)

    Toda, Nicholas R. T.; Song, Jeremy; Nieh, James C.

    2009-10-01

    Associative learning is key to how bees recognize and return to rewarding floral resources. It thus plays a major role in pollinator floral constancy and plant gene flow. Honeybees are the primary model for pollinator associative learning, but bumblebees play an important ecological role in a wider range of habitats, and their associative learning abilities are less well understood. We assayed learning with the proboscis extension reflex (PER), using a novel method for restraining bees (capsules) designed to improve bumblebee learning. We present the first results demonstrating that bumblebees exhibit the memory spacing effect. They improve their associative learning of odor and nectar reward by exhibiting increased memory acquisition, a component of long-term memory formation, when the time interval between rewarding trials is increased. Bombus impatiens forager memory acquisition (average discrimination index values) improved by 129% and 65% at inter-trial intervals (ITI) of 5 and 3 min, respectively, as compared to an ITI of 1 min. Memory acquisition rate also increased with increasing ITI. Encapsulation significantly increases olfactory memory acquisition. Ten times more foragers exhibited at least one PER response during training in capsules as compared to traditional PER harnesses. Thus, a novel conditioning assay, encapsulation, enabled us to improve bumblebee-learning acquisition and demonstrate that spaced learning results in better memory consolidation. Such spaced learning likely plays a role in forming long-term memories of rewarding floral resources.

  10. Greater night-to-night variability in sleep discrepancy among older adults with a sleep complaint compared to noncomplaining older adults.

    PubMed

    Kay, Daniel B; Dzierzewski, Joseph M; Rowe, Meredeth; McCrae, Christina S

    2013-04-01

    Research in younger adults suggests sleep discrepancy (objective/subjective measurement difference) is a consistent pattern that primarily occurs within individuals with insomnia. To examine whether older adults exhibit a similar pattern, this study compared night-to-night inconsistency in sleep discrepancy between older adults with and without sleep complaints. Older adults (N = 103; mean age = 72.81, SD = 7.12) wore an Actiwatch-L® (24 hr per day) and concurrently completed sleep diaries for 14 days. Sleep discrepancy = diary (sleep onset latency [SOL] or wake [time] after sleep onset [WASO]) - actigraphy (SOL or WASO). Both groups exhibited sleep discrepancy, but complainers exhibited significantly more night-to-night variability. Sleep discrepancy was a variable behavior that was not limited to insomnia, but instead manifested by degree throughout our older sample. Greater attention to variability in sleep research and clinical practice is warranted. PMID:23137288

  11. Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults.

    PubMed

    Lissner, Michelle M; Thomas, Brandon J; Wee, Kathleen; Tong, Ann-Jay; Kollmann, Tobias R; Smale, Stephen T

    2015-01-01

    A variety of age-related differences in the innate and adaptive immune systems have been proposed to contribute to the increased susceptibility to infection of human neonates and older adults. The emergence of RNA sequencing (RNA-seq) provides an opportunity to obtain an unbiased, comprehensive, and quantitative view of gene expression differences in defined cell types from different age groups. An examination of ex vivo human monocyte responses to lipopolysaccharide stimulation or Listeria monocytogenes infection by RNA-seq revealed extensive similarities between neonates, young adults, and older adults, with an unexpectedly small number of genes exhibiting statistically significant age-dependent differences. By examining the differentially induced genes in the context of transcription factor binding motifs and RNA-seq data sets from mutant mouse strains, a previously described deficiency in interferon response factor-3 activity could be implicated in most of the differences between newborns and young adults. Contrary to these observations, older adults exhibited elevated expression of inflammatory genes at baseline, yet the responses following stimulation correlated more closely with those observed in younger adults. Notably, major differences in the expression of constitutively expressed genes were not observed, suggesting that the age-related differences are driven by environmental influences rather than cell-autonomous differences in monocyte development. PMID:26147648

  12. 29 CFR 2200.70 - Exhibits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... separate file designated for rejected exhibits. (e) Return of physical exhibits. A party may on motion request the return of a physical exhibit within 30 days after expiration of the time for filing a petition... proceeding. (f) Request for custody of physical exhibit. Any person may on motion to the Executive...

  13. 29 CFR 2200.70 - Exhibits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... separate file designated for rejected exhibits. (e) Return of physical exhibits. A party may on motion request the return of a physical exhibit within 30 days after expiration of the time for filing a petition... proceeding. (f) Request for custody of physical exhibit. Any person may on motion to the Executive...

  14. 29 CFR 2200.70 - Exhibits.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... separate file designated for rejected exhibits. (e) Return of physical exhibits. A party may on motion request the return of a physical exhibit within 30 days after expiration of the time for filing a petition... proceeding. (f) Request for custody of physical exhibit. Any person may on motion to the Executive...

  15. Exhibits Enhanced by Stand-Alone Computers.

    ERIC Educational Resources Information Center

    Van Rennes, Eve C.

    Both the development and evaluation of one of a set of computer programs designed for use by visitors as adjuncts to museum exhibits are described. Museum displays used were (1) a static, behind-glass exhibit on evolution; (2) a hands-on primitive stone age tools exhibit; and (3) a Foucault pendulum. A computer placed next to each exhibit served…

  16. Modelling the Future: Exhibitions and the Materiality of Education

    ERIC Educational Resources Information Center

    Lawn, Martin, Ed.

    2009-01-01

    The role of World Exhibitions in the 19th and early 20th centuries was to confirm a relation between the nation state and modernity. As a display about industries, inventions and identities, the Exhibition, in a sense, put entire nations into an elevated, viewable space. It is a significant element in modernity as comparisons can be made, progress…

  17. A Critical Appraisal of State Level Science Exhibition

    ERIC Educational Resources Information Center

    Nath, Baiju K.

    2007-01-01

    Science exhibitions are really great opportunities to students as well as teachers to disseminate knowledge that they have, and to experience a variety of new inventions and innovations that also need wide dissemination. The great significance of exhibition is that it fosters acquisition of different process skills leading to the development of…

  18. Detection and Management of Air Sac Trematodes (Szidatitrema Species) in Captive Multispecies Avian Exhibits.

    PubMed

    Delaski, Kristina M; Nelson, Sudona; Dronen, Norman O; Craig, Thomas M; Pond, Joel; Gamble, Kathryn C

    2015-12-01

    From 2 exhibits in a zoological collection, 2 juvenile fairy bluebirds ( Irena puella ) and 1 adult blue-grey tanager (Thraupis episcopus) died within 3 months of one another. The cause of death was attributed to air sac trematodes, which were identified as Szidatitrema species based on morphology of adult trematodes and miracidia isolated from a snail intermediate host. To determine the extent of trematodiasis in the collection, individual exhibits within the same building as the original presenting cases were assessed, with birds representing 27 avian species from 9 orders. Sampling consisted of individual (n = 244) and pooled same-species group (n = 193) fecal examinations, and for some individuals, and tracheal swab (n = 106), resulting in a total of 543 samples. In addition, tracheal swabs were performed on 14 birds for comparative cytology, but no parasites were found. Flukes were positively identified in 4 tracheal swab samples (4%), 37 individual fecal samples (15%), and 52 of the group fecal samples (27%). When results of the swab method were compared with those of fecal examination, fecal testing was significantly associated (P < .001) with positive results. Based on these results, a screening process was instituted of 3- or 4-day combined fecal samples evaluated by both sedimentation and flotation techniques 2 weeks before outgoing shipments or intrazoo transfers of birds housed in exhibits known to have snail populations. Snail control methods also were initiated in all exhibits. Treatment with praziquantel was carried out on a case-by-case basis, and included oral, parenteral, and nebulized administration. Although control measures were expected to manage the infection and reduce distribution of the parasite to other collections, complete eradication of trematodes in the population is unlikely. PMID:26771325

  19. Adult Cancers in Adolescents and Young Adults.

    PubMed

    Laurence, Valérie; Marples, Maria; Stark, Daniel P

    2016-01-01

    The pattern of cancer seen in young people changes with increasing age, transitioning from childhood- to adult-type cancer in adolescence and the third decade. The risk factors, presentation and biology of cancer in young adults differ from those in the older adult population. Factors of particular significance in adolescents and young adults (AYAs) include genetic predisposition to adult-type cancer, diagnostic uncertainty, long-term morbidity and considerations of fertility. New systemic therapies are being introduced that can prolong life and even increase the chance of cure, but the impact on AYAs is uncertain, as these patients are often under-represented in clinical trials. Here, we discuss the management of AYAs with 3 of the most common cancers affecting adults, when they emerge in the AYA populations, and therefore are currently met by medical oncologists - breast cancer, colorectal cancer and melanoma. PMID:27595357

  20. Good News? Codling Moth Exhibits Negative Cross Resistance Between Guthion and Rimon

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The responses of adult codling moth from several field-collected populations and a laboratory-reared colony to residues of Rimon were evaluated in plastic cup adult bioassays. Both fecundity and successful egg hatch varied among populations. Populations of codling moth that exhibited the highest LC5...

  1. Supercomputing meets seismology in earthquake exhibit

    ScienceCinema

    Blackwell, Matt; Rodger, Arthur; Kennedy, Tom

    2014-07-22

    When the California Academy of Sciences created the "Earthquake: Evidence of a Restless Planet" exhibit, they called on Lawrence Livermore to help combine seismic research with the latest data-driven visualization techniques. The outcome is a series of striking visualizations of earthquakes, tsunamis and tectonic plate evolution. Seismic-wave research is a core competency at Livermore. While most often associated with earthquakes, the research has many other applications of national interest, such as nuclear explosion monitoring, explosion forensics, energy exploration, and seismic acoustics. For the Academy effort, Livermore researchers simulated the San Andreas and Hayward fault events at high resolutions. Such calculations require significant computational resources. To simulate the 1906 earthquake, for instance, visualizing 125 seconds of ground motion required over 1 billion grid points, 10,000 time steps, and 7.5 hours of processor time on 2,048 cores of Livermore's Sierra machine.

  2. Supercomputing meets seismology in earthquake exhibit

    SciTech Connect

    Blackwell, Matt; Rodger, Arthur; Kennedy, Tom

    2013-10-03

    When the California Academy of Sciences created the "Earthquake: Evidence of a Restless Planet" exhibit, they called on Lawrence Livermore to help combine seismic research with the latest data-driven visualization techniques. The outcome is a series of striking visualizations of earthquakes, tsunamis and tectonic plate evolution. Seismic-wave research is a core competency at Livermore. While most often associated with earthquakes, the research has many other applications of national interest, such as nuclear explosion monitoring, explosion forensics, energy exploration, and seismic acoustics. For the Academy effort, Livermore researchers simulated the San Andreas and Hayward fault events at high resolutions. Such calculations require significant computational resources. To simulate the 1906 earthquake, for instance, visualizing 125 seconds of ground motion required over 1 billion grid points, 10,000 time steps, and 7.5 hours of processor time on 2,048 cores of Livermore's Sierra machine.

  3. Periadolescent rats (P41-50) exhibit increased susceptibility to D-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60).

    PubMed

    Vorhees, Charles V; Reed, Tracy M; Morford, LaRonda L; Fukumura, Masao; Wood, Sandra L; Brown, Carrie A; Skelton, Matthew R; McCrea, Anne E; Rock, Stephanie L; Williams, Michael T

    2005-01-01

    We have previously shown that P11-20 treatment with d-methamphetamine (MA) induces impaired spatial navigation in the Morris water maze (MWM), whereas P1-10 treatment does not. Little is known about the long-term behavioral consequences of MA during juvenile, adolescent, and early adult brain development. In dose-response experiments, we tested successive 10-day intervals of exposure to MA in rats (P21-30, P31-40, P41-50, and P51-60; four doses per day). MA dosing prior to P21 produces little or no toxicity; however, we observed an increased toxicity with advancing age. Across-age comparisons revealed no MWM acquisition or Cincinnati water maze (CWM) effects after MA treatment on P21-30 (2.5-10 mg/kg/dose), P31-40 (1.25-7.5 mg/kg/dose), or P51-60 (1.25-5.0 mg/kg/dose); however, significantly impaired MWM acquisition was observed after P41-50 MA treatment at the highest dose (6.25 mg/kg/dose). Learning in the CWM was also impaired in this group. No effects were seen at 1.25, 2.5, or 5 mg/kg/dose following P41-50 MA treatment. MWM reversal learning trials after P41-50 treatment showed a trend towards longer latency in all MA dose groups, but no effect on double-reversal trials. Reversal and double-reversal also showed no effects at the other exposure ages. No differences in straight channel swimming or cued learning in the MWM were seen after MA treatment at any exposure age. P41-50 is the periadolescent stage of brain development in rodents. The effects observed at this age may suggest a previously unrecognized period of susceptibility for MA-induced cognitive deficits. PMID:15681126

  4. Extract from Ceratonia siliqua Exhibits Depigmentation Properties.

    PubMed

    Lall, Namrita; Kishore, Navneet; Momtaz, Saeideh; Hussein, Ahmed; Naidoo, Sanushka; Nqephe, Mabatho; Crampton, Bridget

    2015-11-01

    Skin hyper-pigmentation is a condition initiated by the overproduction of melanin existing in the melanocytes. Melanin pigment is responsible for the colour of skin in humans. It is formed through a series of oxidative reactions involving the amino acid tyrosine in the presence of the key enzyme tyrosinase. In continuation with our efforts to identify tyrosinase inhibitors from plants sources, the methanol extract from leaf, bark and fruit of Ceratonia siliqua were screened for tyrosinase inhibition and diphenolase activity. The bark extract exhibited significant inhibition on mushroom tyrosinase using L-tyrosine as a substrate and showed diphenolase activity. The extract further significantly lowered tyrosinase mRNA levels in B16-F10 mouse melanocytes. Bioassay-guided fractionation led to the isolation of six compounds. Compounds (-)-epicatechin-3-O-gallate, 1,2,3,6-tetra-O-galloyl-ß-D-glucose and gallocatechin-3-O-gallate showed tyrosinase inhibitions with the IC50 values of 27.52, 83.30 and 28.30 µg/mL, respectively. These compounds also exhibited L-DOPA activities with IC50 values of >200, 150 and 200 µg/mL, respectively. A clinical study was conducted using 20 volunteers in a patch testing trial for irritancy potential and skin depigmentation. The clinical results showed the sample to be non-irritant with irritancy potential of -34.21 and depigmentation trial showed an improvement in the even skin tone of UV induced pigmentation at 3% after 28 days of application. PMID:26201055

  5. Absence of Significant Cool Disks in Young Stellar Objects Exhibiting Repetitive Optical Outbursts

    NASA Astrophysics Data System (ADS)

    Liu, Hauyu Baobab; Galván-Madrid, Roberto; Vorobyov, Eduard I.; Kóspál, Ágnes; Rodríguez, Luis F.; Dunham, Michael M.; Hirano, Naomi; Henning, Thomas; Takami, Michihiro; Dong, Ruobing; Hashimoto, Jun; Hasegawa, Yasuhiro; Carrasco-González, Carlos

    2016-01-01

    We report Submillimeter Array 1.3 mm high angular resolution observations toward the four EXor-type outbursting young stellar objects VY Tau, V1118 Ori, V1143 Ori, and NY Ori. The data mostly show low dust masses Mdust in the associated circumstellar disks. Among the sources, NY Ori possesses a relatively massive disk with Mdust ˜ 9 × 10-4M⊙. V1118 Ori has a marginal detection equivalent to Mdust ˜ 6 × 10-5M⊙. V1143 Ori has a non-detection also equivalent to Mdust < 6 × 10-5M⊙. For the nearest source, VY Tau, we get a surprising non-detection that provides a stringent upper limit Mdust < 6 × 10-6M⊙. We interpret our findings as suggesting that the gas and dust reservoirs that feed the short-duration, repetitive optical outbursts seen in some EXors may be limited to the small-scale, innermost region of their circumstellar disks. This hot dust may have escaped our detection limits. Follow-up, more sensitive millimeter observations are needed to improve our understanding of the triggering mechanisms of EXor-type outbursts.

  6. 78 FR 52996 - Culturally Significant Objects Imported for Exhibition Determinations: “Face to Face: Flanders...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  7. 75 FR 22172 - Culturally Significant Objects Imported for Exhibition Determinations: “Vatican Splendors”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... objects at the Missouri History Museum, Saint Louis, Missouri, from on or about May 15, 2010, until on or about September 12, 2010, the Senator John Heinz History Center, Pittsburgh, Pennsylvania, from on or about October 2, 2010, until on or about January 9, 2011, the Museum of Art, Nova...

  8. 76 FR 15358 - Culturally Significant Objects Imported for Exhibition Determinations: “Before the Pyramids: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-21

    ... Egyptian Civilization'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... ``Before the Pyramids: The Origins of Egyptian Civilization'' imported from abroad for temporary...

  9. 76 FR 42158 - Culturally Significant Objects Imported for Exhibition Determinations: “Lyonel Feininger...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... Museum, Los Angeles, CA, from on or about October 25, 2011, until on or about March 11, 2012; Harvard Art Museums, Cambridge, MA, from on or about March 30, 2012, until on or about June 2, 2012, and at...

  10. 78 FR 52997 - Culturally Significant Objects Imported for Exhibition Determinations: “Yoga: the Art of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-27

    ... Institution, Washington, DC, from on or about October 19, 2013, until on or about January 26, 2014; The Asian Art Museum, San Francisco, CA, from on or about February 21, 2014, until on or about May 25, 2014; The Cleveland Museum of Art, from on or about June 22, 2014, until on or about September 7, 2014, and...

  11. 78 FR 52601 - Culturally Significant Object Imported for Exhibition; Determinations: “Visiting Masterpiece...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... Francesca's Senigallia Madonna, an Italian Treasure, Stolen and Recovered'' and ``Piero della Francesca...: Piero della Francesca's Senigallia Madonna, An Italian Treasure, Stolen and Recovered'' at the Museum...

  12. 76 FR 6650 - Culturally Significant Objects Imported for Exhibition Determinations: “Birth of the Modern...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... Identity in Vienna 1900'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... ``Birth of the Modern: Style and Identity in Vienna 1900,'' imported from abroad for temporary...

  13. 78 FR 18664 - Culturally Significant Objects Imported for Exhibition Determinations: “Diaghilev and the Ballets...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-27

    ..., 1909-1929: When Art Danced With Music'' SUMMARY: Notice is hereby given of the following determinations... the Ballets Russes, 1909- 1929: When Art Danced with Music,'' imported from abroad for...

  14. 75 FR 53013 - Culturally Significant Objects Imported for Exhibition Determinations: “Chaos and Classicism: Art...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  15. 78 FR 2479 - Culturally Significant Objects Imported for Exhibition Determinations: “Georges Braque and the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-11

    ..., 2013, and then at The Phillips Collection in Washington, DC from on or about June 8, 2013 until on or... Floor (Suite 5H03), Washington, DC 20522-0505. Dated: January 4, 2013. J. Adam Ereli, Principal...

  16. 78 FR 11264 - Culturally Significant Objects Imported for Exhibition Determinations: “The Cyrus Cylinder in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  17. 75 FR 82127 - Culturally Significant Objects Imported for Exhibition Determinations: “Central Nigeria Unmasked...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-29

    ... February 13, 2011, until on or about July 24, 2011, the National Museum of African Art, Smithsonian Institution, Washington, DC, from on or about September 14, 2011, until on or about March 4, 2012, the...

  18. 76 FR 30228 - Culturally Significant Object Imported for Exhibition; Determinations: “Portrait of a Man”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  19. 75 FR 43225 - Culturally Significant Objects Imported for Exhibition Determinations: “Man, Myth, and Sensual...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  20. 75 FR 17197 - Culturally Significant Objects Imported for Exhibition Determinations: “Cyprus: Crossroads of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... of Natural History, Washington, DC, from on or about September 1, 2010, until on or about April 15... Professional and Cultural Exchanges, Bureau of Educational and Cultural Affairs, Department of State....

  1. 77 FR 41473 - Culturally Significant Objects Imported for Exhibition Determinations: “Projects 98: Slavs and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-13

    ..., et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No. 236-3.... Department of State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: June 29, 2012....

  2. 76 FR 16851 - Culturally Significant Objects Imported for Exhibition Determinations: “Seeing Gertrude Stein...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ..., et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No. 236-3.... Department of State (telephone: 202-632-6469). The mailing address is U.S. Department of State, SA-5,...

  3. 76 FR 27742 - Culturally Significant Objects Imported for Exhibition Determinations: “Picasso: Masterpieces...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-12

    ....; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of.... Department of State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: May 6, 2011....

  4. 77 FR 51103 - Culturally Significant Objects Imported for Exhibition Determinations: “Ferdinand Hodler: View to...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ..., et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No. 236-3 of... State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: August 15, 2012. J....

  5. 77 FR 10599 - Culturally Significant Objects Imported for Exhibition Determinations: “Elegance and Refinement...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    .... 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and... mailing address is U.S. Department of State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC...

  6. 75 FR 32980 - Culturally Significant Objects Imported for Exhibition Determinations: “Olmec: Masterworks of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No. 236......

  7. 78 FR 68134 - Culturally Significant Objects Imported for Exhibition Determinations: “Renaissance to Goya...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ....; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of... (telephone: 202- 632-6469). The mailing address is U.S. Department of State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: November 1, 2013. Evan M. Ryan, Assistant Secretary, Bureau...

  8. 77 FR 56251 - Culturally Significant Objects Imported for Exhibition Determinations: “Picasso Black and White”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-12

    ....), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No. 236-3 of August 28, 2000..., SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: September 5, 2012. J....

  9. 78 FR 39435 - Culturally Significant Objects Imported for Exhibition; Determinations: “Magritte: The Mystery of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-01

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  10. 76 FR 33398 - Culturally Significant Objects Imported for Exhibition Determinations; “Lyonel Feininger: At the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-08

    ....S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of.... Department of State (telephone: 202-632-6469). The ] mailing address is U.S. Department of State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC 20522-0505. Dated: June 1, 2011. Ann Stock, Assistant...

  11. 76 FR 52044 - Culturally Significant Objects Imported for Exhibition Determinations: “Modern Antiquity: Picasso...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-19

    .... 234 of October 1, 1999, and Delegation of Authority No. 236-3 of August 28, 2000 (and, as appropriate...: 202-632-6473). The mailing address is U.S. Department of State, SA-5, L/PD, Fifth Floor (Suite...

  12. 76 FR 73759 - Culturally Significant Objects Imported for Exhibition Determinations: “In Wonderland: The...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    .... 234 of October 1, 1999, and Delegation of Authority No. 236-3 of August 28, 2000 (and, as appropriate... mailing address is U.S. Department of State, SA-5, L/PD, Fifth Floor (Suite 5H03), Washington, DC...

  13. 78 FR 62355 - Culturally Significant Objects Imported for Exhibition Determinations: “Ileana Sonnabend...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-18

    ....S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of... (telephone: 202- 632-6469). The mailing address is U.S. Department of State, SA-5, L/PD, Fifth Floor...

  14. 76 FR 56491 - Culturally Significant Objects Imported for Exhibition Determinations: “Tombs, Temples and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  15. 77 FR 25780 - Culturally Significant Objects Imported for Exhibition Determinations: “Rembrandt, Van Dyck...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  16. 75 FR 1680 - Culturally Significant Objects Imported for Exhibition: Determinations: “Giovanni Boldini in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No. 236......

  17. 76 FR 4986 - Culturally Significant Object Imported for Exhibition Determinations: “Gentile Bellini: Portrait...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-27

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  18. 77 FR 73511 - Culturally Significant Objects Imported for Exhibition Determinations: “Arts of Islamic Lands...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-10

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  19. 76 FR 2439 - Culturally Significant Objects Imported for Exhibition Determinations: “Cézanne's Card Players”

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-13

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  20. 78 FR 5555 - Culturally Significant Object Imported for Exhibition Determinations: “Piero della Francesca in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE...'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27,...