Science.gov

Sample records for advanced central receiver

  1. Advanced Thermal Storage for Central Receivers with Supercritical Coolants

    SciTech Connect

    Kelly, Bruce D.

    2010-06-15

    The principal objective of the study is to determine if supercritical heat transport fluids in a central receiver power plant, in combination with ceramic thermocline storage systems, offer a reduction in levelized energy cost over a baseline nitrate salt concept. The baseline concept uses a nitrate salt receiver, two-tank (hot and cold) nitrate salt thermal storage, and a subcritical Rankine cycle. A total of 6 plant designs were analyzed, as follows: Plant Designation Receiver Fluid Thermal Storage Rankine Cycle Subcritical nitrate salt Nitrate salt Two tank nitrate salt Subcritical Supercritical nitrate salt Nitrate salt Two tank nitrate salt Supercritical Low temperature H2O Supercritical H2O Two tank nitrate salt Supercritical High temperature H2O Supercritical H2O Packed bed thermocline Supercritical Low temperature CO2 Supercritical CO2 Two tank nitrate salt Supercritical High temperature CO2 Supercritical CO2 Packed bed thermocline Supercritical Several conclusions have been drawn from the results of the study, as follows: 1) The use of supercritical H2O as the heat transport fluid in a packed bed thermocline is likely not a practical approach. The specific heat of the fluid is a strong function of the temperatures at values near 400 °C, and the temperature profile in the bed during a charging cycle is markedly different than the profile during a discharging cycle. 2) The use of supercritical CO2 as the heat transport fluid in a packed bed thermocline is judged to be technically feasible. Nonetheless, the high operating pressures for the supercritical fluid require the use of pressure vessels to contain the storage inventory. The unit cost of the two-tank nitrate salt system is approximately $24/kWht, while the unit cost of the high pressure thermocline system is nominally 10 times as high. 3) For the supercritical fluids, the outer crown temperatures of the receiver tubes are in the range of 700 to 800 °C. At temperatures of 700 °C and above

  2. Evaluation of advanced sodium receiver losses during operation of the IEA/SSPS central receiver system

    SciTech Connect

    Carmona, R.; Rosa, F.; Jacobs, H.; Sanchez, M.

    1989-02-01

    This article presents the measurements and experiments conducted on the external receiver: the so-called Advanced Sodium Receiver (ASR) of the Small Solar Power Systems (SSPS) Project of the International Energy Agency (IEA) in southern Spain. The basis of this experiment was to provide loss measurements for later use in determining receiver performance. The tests to evaluate thermal losses consisted in operating the receiver with the doors open and circulating the sodium in normal and reverse flow without providing any incident power from the heliostat field (flux-off technique). In this way, total thermal losses are calculated as the energy lost by the sodium. Radiative losses have been calculated based on theoretical calculations and some results have been compared with infrared thermography measurements. Conductive losses are small and have been estimated by flux-off experiments with the receiver doors closed. Convective losses were evaluated subtracting radiative and conductive losses from the total thermal losses. Optical losses were assessed using absorptance measurements of the receiver coating. A simplified analytical model has been developed to calculate losses and ASR efficiency during operation. In spite of the method's simplicity, the results are very similar to those found by other investigators, verified simulation programs and test results.

  3. Central receiver technology

    SciTech Connect

    Holl, R.L. )

    1989-09-01

    The research and development described in this document was conducted within the US Department of Energy's (DOE) Solar Thermal Technology Program. The goal of this program is to advance the engineering and scientific understanding of solar thermal technology and to establish the technology base from which private industry can develop solar thermal power production options for introduction into the competitive energy market. This report describes central receiver technology: its accomplishments to date, its current technology status, and the efforts still necessary to fully exploit it.

  4. Central solar energy receiver

    DOEpatents

    Drost, M. Kevin

    1983-01-01

    An improved tower-mounted central solar energy receiver for heating air drawn through the receiver by an induced draft fan. A number of vertically oriented, energy absorbing, fin-shaped slats are radially arranged in a number of concentric cylindrical arrays on top of the tower coaxially surrounding a pipe having air holes through which the fan draws air which is heated by the slats which receive the solar radiation from a heliostat field. A number of vertically oriented and wedge-shaped columns are radially arranged in a number of concentric cylindrical clusters surrounding the slat arrays. The columns have two mirror-reflecting sides to reflect radiation into the slat arrays and one energy absorbing side to reduce reradiation and reflection from the slat arrays.

  5. Central solar-energy receiver

    DOEpatents

    Not Available

    1981-10-27

    An improved tower-mounted central solar energy receiver for heating air drawn through the receiver by an induced draft fan is described. A number of vertically oriented, energy absorbing, fin-shaped slats are radially arranged in a number of concentric cylindrical arrays on top of the tower coaxially surrounding a pipe having air holes through which the fan draws air which is heated by the slats which receive the solar radiation from a heliostat field. A number of vertically oriented and wedge-shaped columns are radially arranged in a number of concentric cylindrical clusters surrounding the slat arrays. The columns have two mirror-reflecting sides to reflect radiation into the slat arrays and one energy absorbing side to reduce reradiation and reflection from the slat arrays.

  6. Second-generation central receiver technology comparison

    NASA Astrophysics Data System (ADS)

    Klimas, P. C.; Becker, M.

    Fifteen years of solar thermal technology development have produced a considerable amount of knowledge relating to the production of electricity from central receiver power plants. This body of knowledge is under examination by researchers from the United States and the Federal Republic of Germany for the purpose of defining the next generation central receiver electricity producers. This second generation power plant is expected to represent a significant step towards commercialization of these systems. During the course of the study, specific activities needed to realize this next-step technology are being defined. The study is an international team effort. Under the International Energy Agency Small Solar Power Systems project, researchers from DLR, Interatom, Sandia National Laboratories, and Bechtel have designed a study in which technologies relating to existing systems are quantified, logical next-step systems are characterized, and future potential advances are identified. The receiver concepts under investigation are: salt-in-tube, volumetric, and direct absorption. Two plant performance levels are examined, 30 and 100 MW(sub e). Each concept is applied with common capacity factors, solar multiples, and types and sizes of heliostats at each performance level. Availability and uncertainty analyses are also performed. Annual energy production figures are calculated using the SOLERGY computer code. Capital and Operation and Maintenance cost methodologies are mutually agreed upon in order that levelized energy cost calculations will be consistent for each power plant. During the course of this effort, further potential advances in central receiver technology have continued to become apparent. These possible areas for improvement will be described. An additional comparison is being made between central receivers and trough-based systems.

  7. Advances in SIS receiver technology

    NASA Technical Reports Server (NTRS)

    Frerking, M. A.

    1988-01-01

    Significant advances in SIS receiver technology since the last Asilomar meeting include: superconductor materials, integrated inductive tuning elements, and planar mounting structures. The effect of these advances is to push the upper frequency operating limit from about 600 to 1500 GHz, and to enhance the feasibility of focal plane arrays of heterodyne receivers. A fundamental high frequency operating limit of SIS mixers is set by the superconducting energy gap. A practical limitation for high frequency operation of SIS junctions is their parasitic capacitance and resistance. The performance of the mixer will be degraded by the Resistor-Capacitor rolloff. Several designs were reported for inductive elements integrated on the same substrate as the SIS junctions to tune out the bulk junction capacitance. Most millimeter SIS-based heterodyne receivers have used waveguide coupling structures. Technology has advanced to the state where programs that have a high probability of success can be defined to produce arrays of SIS receivers for frequencies as high as 1500 GHz.

  8. Solar central receiver systems comparative economics

    SciTech Connect

    Eicker, P J

    1980-04-01

    Several major conceptual design studies of solar central receiver systems and components have been completed in the last year. The results of these studies are used to compare the projected cost of electric power generation using central receiver systems with that of more conventional power generation. The cost estimate for a molten salt central receiver system is given. Levelized busbar energy cost is shown as a function of annual capacity factor indicating the fraction of the cost due to each of the subsystems. The estimated levelized busbar energy cost for a central receiver (70 to 90 mills per kilowatt hour) is compared with the levelized busbar energy cost for a new coal fired Rankine cycle plant. Sensitivities to the initial cost of coal and the delta fuel escalation are shown. (WHK)

  9. A handbook for solar central receiver design

    SciTech Connect

    Falcone, P.K.

    1986-12-01

    This Handbook describes central receiver technology for solar thermal power plants. It contains a description and assessment of the major components in a central receiver system configured for utility scale production of electricity using Rankine-cycle steam turbines. It also describes procedures to size and optimize a plant and discussed examples from recent system analyses. Information concerning site selection criteria, cost estimation, construction, and operation and maintenance is also included, which should enable readers to perform design analyses for specific applications.

  10. Chip Advancer For GPS Receiver

    NASA Technical Reports Server (NTRS)

    Meehan, Thomas K.; Srinivasan, Jeffrey M.; Thomas, J. Brooks

    1989-01-01

    Instrument errors made negligible. For each integration interval, both delay and rate of change of delay initialized to small fraction of chip - for example, to order of 10 to the negative 7th power - thereby making feedback control and extraction of delay highly accurate and flexible. With appropriate selection of sampling rate relative to chip rate, commensurability errors reduced to extremely small levels. In Global Positioning System (GPS) receiver, pseudorandom code sequence generated by simple digital logic incorporating effects of time, delay, and rate of change of delay. Flexibility in starting time and sum interval very useful in aligning correlation interval with beginnings and endings of data bits.

  11. Telemetry Tests Of The Advanced Receiver II

    NASA Technical Reports Server (NTRS)

    Hinedi, Sami M.; Bevan, Roland P.; Marina, Miguel

    1993-01-01

    Report describes telemetry tests of Advanced Receiver II (ARX-II): digital radio receiving subsystem operating on intermediate-frequency output of another receiving subsystem called "multimission receiver" (MMR), detecting carrier, subcarrier, and data-symbol signals transmitted by spacecraft, and extracts Doppler information from signals. Analysis of data shows performance of MMR/ARX-II system comparable and sometimes superior to performances of Blk-III/BPA and Blk-III/SDA/SSA systems.

  12. Solar central receiver integration with Hoover Dam

    SciTech Connect

    Remmers, H.E.; Zelenka, R.L.; Kitchen, J.H.

    1980-01-01

    The technical and economic feasibility of integrating a 100 MWe solar central receiver powerplant located in Yuma, Arizona with the Hoover Dam hydroelectric power system is discussed. Technical feasibility was determined by evaluating the effects of integration on the hydrologic and power operations of the existing hydro system. Economic feasibility was determined by comparing the costs of the integrated system with that of the most likely alternative source of power generation--an oil-fired,combined-cycle plant.

  13. Advanced heat receiver conceptual design study

    NASA Technical Reports Server (NTRS)

    Kesseli, James; Saunders, Roger; Batchelder, Gary

    1988-01-01

    Solar Dynamic space power systems are candidate electrical power generating systems for future NASA missions. One of the key components of the solar dynamic power system is the solar receiver/thermal energy storage (TES) subsystem. Receiver development was conducted by NASA in the late 1960's and since then a very limited amount of work has been done in this area. Consequently the state of the art (SOA) receivers designed for the IOC space station are large and massive. The objective of the Advanced Heat Receiver Conceptual Design Study is to conceive and analyze advanced high temperature solar dynamic Brayton and Stirling receivers. The goal is to generate innovative receiver concepts that are half of the mass, smaller, and more efficient than the SOA. It is also necessary that these innovative receivers offer ease of manufacturing, less structural complexity and fewer thermal stress problems. Advanced Brayton and Stirling receiver storage units are proposed and analyzed in this study which can potentially meet these goals.

  14. Solar central receiver heliostat reflector assembly

    DOEpatents

    Horton, Richard H.; Zdeb, John J.

    1980-01-01

    A heliostat reflector assembly for a solar central receiver system comprises a light-weight, readily assemblable frame which supports a sheet of stretchable reflective material and includes mechanism for selectively applying tension to and positioning the sheet to stretch it to optical flatness. The frame is mounted on and supported by a pipe pedestal assembly that, in turn, is installed in the ground. The frame is controllably driven in a predetermined way by a light-weight drive system so as to be angularly adjustable in both elevation and azimuth to track the sun and efficiently continuously reflect the sun's rays to a focal zone, i.e. central receiver, which forms part of a solar energy utilization system, such as a solar energy fueled electrical power generation system. The frame may include a built-in system for testing for optical flatness of the reflector. The preferable geometric configuration of the reflector is octagonal; however, it may be other shapes, such as hexagonal, pentagonal or square. Several different embodiments of means for tensioning and positioning the reflector to achieve optical flatness are disclosed. The reflector assembly is based on the stretch frame concept which provides an extremely light-weight, simple, low-cost reflector assembly that may be driven for positioning and tracking by a light-weight, inexpensive drive system.

  15. Transient simulation of molten salt central receiver

    NASA Astrophysics Data System (ADS)

    Doupis, Dimitri; Wang, Chuan; Carcorze-Soto, Jorge; Chen, Yen-Ming; Maggi, Andrea; Losito, Matteo; Clark, Michael

    2016-05-01

    Alstom is developing concentrated solar power (CSP) utilizing 60/40wt% NaNO3-KNO3 molten salt as the working fluid in a tower receiver for the global renewable energy market. In the CSP power generation cycle, receivers undergo a daily cyclic operation due to the transient nature of solar energy. Development of robust and efficient start-up and shut-down procedures is critical to avoiding component failures due to mechanical fatigue resulting from thermal transients, thus maintaining the performance and availability of the CSP plant. The Molten Salt Central Receiver (MSCR) is subject to thermal transients during normal daily operation, a cycle that includes warmup, filling, operation, draining, and shutdown. This paper describes a study to leverage dynamic simulation and finite element analysis (FEA) in development of start-up, shutdown, and transient operation concepts for the MSCR. The results of the FEA also verify the robustness of the MSCR design to the thermal transients anticipated during the operation of the plant.

  16. Thermal resistance model for CSP central receivers

    NASA Astrophysics Data System (ADS)

    de Meyer, O. A. J.; Dinter, F.; Govender, S.

    2016-05-01

    The receiver design and heliostat field aiming strategy play a vital role in the heat transfer efficiency of the receiver. In molten salt external receivers, the common operating temperature of the heat transfer fluid or molten salt ranges between 285°C to 565°C. The optimum output temperature of 565°C is achieved by adjusting the mass flow rate of the molten salt through the receiver. The reflected solar radiation onto the receiver contributes to the temperature rise in the molten salt by means of heat transfer. By investigating published work on molten salt external receiver operating temperatures, corresponding receiver tube surface temperatures and heat losses, a model has been developed to obtain a detailed thermographic representation of the receiver. The steady state model uses a receiver flux map as input to determine: i) heat transfer fluid mass flow rate through the receiver to obtain the desired molten salt output temperature of 565°C, ii) receiver surface temperatures iii) receiver tube temperatures iv) receiver efficiency v) pressure drop across the receiver and vi) corresponding tube strain per panel.

  17. NCI Central Review Board Receives Accreditation

    Cancer.gov

    The Association for the Accreditation of Human Research Protection Programs has awarded the NCI Central Institutional Review Board full accreditation. AAHRPP awards accreditation to organizations demonstrating the highest ethical standards in clinical res

  18. Financial study of commercialization of solar central receiver power systems

    NASA Astrophysics Data System (ADS)

    1981-03-01

    Commercialization requires that central receiver (CR) systems meet the economic criteria used by industry to select systems for capital ventures. Quantitative estimates are given of the investment required by government, utilities, and the manufacturing sector to meet the energy displacement goals for central receiver technology. Initial solar repowering and stand-alone electric utility plants will not have economic comparability with competitive energy sources. A major factor for this is that initial (first of a kind) heliostat costs will be high. As heliostat costs are reduced due to automated manufacturing economies, learning, and high volume production, central receiver technology will become more competitive. Under this task, several scenarios (0.1, 0.5, and 1.0 quad/y) were evaluated to determine the effect on commercial attractiveness and to determine the cost to government to bring about commercialization of solar central receivers.

  19. Baseload Nitrate Salt Central Receiver Power Plant Design Final Report

    SciTech Connect

    Tilley, Drake; Kelly, Bruce; Burkholder, Frank

    2014-12-12

    The objectives of the work were to demonstrate that a 100 MWe central receiver plant, using nitrate salt as the receiver coolant, thermal storage medium, and heat transport fluid in the steam generator, can 1) operate, at full load, for 6,400 hours each year using only solar energy, and 2) satisfy the DOE levelized energy cost goal of $0.09/kWhe (real 2009 $). To achieve these objectives the work incorporated a large range of tasks relating to many different aspects of a molten salt tower plant. The first Phase of the project focused on developing a baseline design for a Molten Salt Tower and validating areas for improvement. Tasks included a market study, receiver design, heat exchanger design, preliminary heliostat design, solar field optimization, baseline system design including PFDs and P&IDs and detailed cost estimate. The baseline plant met the initial goal of less than $0.14/kWhe, and reinforced the need to reduce costs in several key areas to reach the overall $0.09/kWhe goal. The major improvements identified from Phase I were: 1) higher temperature salt to improve cycle efficiency and reduce storage requirements, 2) an improved receiver coating to increase the efficiency of the receiver, 3) a large receiver design to maximize storage and meet the baseload hours objective, and 4) lower cost heliostat field. The second Phase of the project looked at advancing the baseline tower with the identified improvements and included key prototypes. To validate increasing the standard solar salt temperature to 600 °C a dynamic test was conducted at Sandia. The results ultimately proved the hypothesis incorrect and showed high oxide production and corrosion rates. The results lead to further testing of systems to mitigate the oxide production to be able to increase the salt temperature for a commercial plant. Foster Wheeler worked on the receiver design in both Phase I and Phase II looking at both design and lowering costs utilizing commercial fossil boiler

  20. Solar central receiver reformer system for ammonia plants

    NASA Astrophysics Data System (ADS)

    1980-07-01

    An overview of a study to retrofit the Valley Nitrogen Producers, Inc., El Centro, California 600 ST/SD Ammonia Plant with Solar Central Receiver Technology is presented. The retrofit system consists of a solar central receiver reformer (SCRR) operating in parallel with the existing fossil fired reformer. Steam and hydrocarbon react in the catalyst filled tubes of the inner cavity receiver to form a hydrogen rich mixture which is the syngas feed for the ammonia production. The SCRR system will displace natural gas presently used in the fossil reformer combustion chamber.

  1. Reconfigurable Advanced Receiver Design and Implementation

    NASA Technical Reports Server (NTRS)

    Xu, Jianjing

    2005-01-01

    While the demand for real-time broadband information access has grown and continues to grow at a rapid Pace, the need for a reconfigurable receiver system has increased. To achieve the goal to communicate with multiple shuttles at a time, a filter bank in polyphase structure is introduced. This paper presents the design and implementation for high-speed, high-performance, and fixed-point polyphase filter banks. The polyphase filter structure is designed such that the use of a fixed-point system has minimum impact on the performance of the filter. The final hardware implementation is done on a Xilinx FPGA chip.

  2. Advanced motor driven clamped borehole seismic receiver

    DOEpatents

    Engler, Bruce P.; Sleefe, Gerard E.; Striker, Richard P.

    1993-01-01

    A borehole seismic tool including a borehole clamp which only moves perpendicular to the borehole. The clamp is driven by an electric motor, via a right angle drive. When used as a seismic receiver, the tool has a three part housing, two of which are hermetically sealed. Accelerometers or geophones are mounted in one hermetically sealed part, the electric meter in the other hermetically sealed part, and the clamp and right angle drive in the third part. Preferably the tool includes cable connectors at both ends. Optionally a shear plate can be added to the clamp to extend the range of the tool.

  3. Advanced motor driven clamped borehole seismic receiver

    DOEpatents

    Engler, B.P.; Sleefe, G.E.; Striker, R.P.

    1993-02-23

    A borehole seismic tool is described including a borehole clamp which only moves perpendicular to the borehole. The clamp is driven by an electric motor, via a right angle drive. When used as a seismic receiver, the tool has a three part housing, two of which are hermetically sealed. Accelerometers or geophones are mounted in one hermetically sealed part, the electric motor in the other hermetically sealed part, and the clamp and right angle drive in the third part. Preferably the tool includes cable connectors at both ends. Optionally a shear plate can be added to the clamp to extend the range of the tool.

  4. Advanced Stirling receiver development program, phase 1

    NASA Technical Reports Server (NTRS)

    Lurio, Charles A.

    1990-01-01

    Critical technology experiments were designed and developed to evaluate the Stirling cavity heat pipe receiver for a space solar power system. Theoretical criteria were applied to the design of a module for containing energy storage phase change material while avoiding thermal ratcheting. Zero-g drop tower tests, without phase change, were conducted to affirm that the bubble location required to avoid ratcheting could be achieved without the use of container materials that are wetted by the phase change material. A full scale module was fabricated, but not tested. A fabrication method was successfully developed for the sodium evaporator dome, with a sintered screen wick, to be used as the focal point for the receiver. Crushing of the screen during hydroforming was substantially reduced over the results of other researchers by using wax impregnation. Superheating of the sodium in the wick under average flux conditions is expected to be under 10K. A 2000K furnace which will simulate solar flux conditions for testing the evaporator dome was successfully built and tested.

  5. Hybrid solar central receiver for combined cycle power plant

    DOEpatents

    Bharathan, D.; Bohn, M.S.; Williams, T.A.

    1995-05-23

    A hybrid combined cycle power plant is described including a solar central receiver for receiving solar radiation and converting it to thermal energy. The power plant includes a molten salt heat transfer medium for transferring the thermal energy to an air heater. The air heater uses the thermal energy to preheat the air from the compressor of the gas cycle. The exhaust gases from the gas cycle are directed to a steam turbine for additional energy production. 1 figure.

  6. Hybrid solar central receiver for combined cycle power plant

    DOEpatents

    Bharathan, Desikan; Bohn, Mark S.; Williams, Thomas A.

    1995-01-01

    A hybrid combined cycle power plant including a solar central receiver for receiving solar radiation and converting it to thermal energy. The power plant includes a molten salt heat transfer medium for transferring the thermal energy to an air heater. The air heater uses the thermal energy to preheat the air from the compressor of the gas cycle. The exhaust gases from the gas cycle are directed to a steam turbine for additional energy production.

  7. Third-party financing of central-receiver repowering projects

    SciTech Connect

    Munjal, P. K.; Walter, J.; Mathur, P. N.

    1981-12-01

    An innovative third party financing approach for the first solar thermal repowering plants is investigated that may reduce the need for direct DOE cost sharing during the early application of central receiver technology by industry. Third party refers to a corporation, partnership, or a joint venture that can take advantage of existing financial incentives. The available financial incentives are summarized, including the guaranteed market for central receiver power provided by Section 210 of the Public Utility Regulatory Policy Act, and federal and state tax credits and depreciation schedules. The economics of third party central receiver repowering plant financing is analyzed, and the case history of the Arizona Public Service Utility Saguaro Plant No. 1 is used as an example. Finally, a sensitivity analysis examines the effects of variations of different financial parameters on the return on investment. It is found that a substantial portion of investment equity can be recovered in the first few years of plant operation, and good future years cash flows appear possible. Third party financing appears capable of helping stimulate mass production of heliostats and a rapid transfer of central receiver technology to utilities and industry, with attending economic benefits. (LEW)

  8. Tax barriers to solar central receiver generation technology

    SciTech Connect

    Jenkins, A.F.; Reilly, H.E.

    1994-12-31

    Tax loads and required revenues are estimated for current and future solar central receiver and gas-fired plants competing in the same market. An economic measure of tax equity is used to evaluate the equity of the tax loads under past and present tax codes. The same measure is used to devise a tax strategy which produces the following two types of equitable taxation: (1) the two plants carry nearly equal tax loads, and (2) local, state and federal governments receive the same distribution of revenues from the solar plant as from the gas-fired plant `Me results show that central receivers (and likely other capital-intensive technologies) carry higher tax loads compared to competing gasfired generation, that tax loads are highly correlated with competitiveness, and that equitable taxation is feasible within the boundaries of the study.

  9. Theory of cellwise optimization for solar central receiver system

    NASA Astrophysics Data System (ADS)

    Lipps, F. W.

    1985-05-01

    Cost effective optimization of the solar central receiver system is primarily concerned with the distribution of heliostats in the collector field, including the boundaries of the field. The cellwise optimization procedure determines the optimum cell usage and heliostat spacing parameters for each cell in the collector field. Spacing parameters determine the heliostat density and neighborhood structure uniformly in each cell. Consequently, the cellwise approach ignores heliostat mismatch at cell boundaries. Ignoring the cell boundary problem permits an easy solution for the optimum in terms of appropriately defined annual average data. Insolation, receiver interception, shading and blocking, cosine effects, and the cost parameters combine to control the optimum. Many trade offs are represented. Outputs include the receiver flux density distribution for design time, coefficients for an actual layout, the optimum boundary and various performance and cost estimates for the optimum field. It is also possible to optimize receiver size and tower height by a repeated application of the field optimization procedure.

  10. Technical developments in molten salt solar central receiver systems

    SciTech Connect

    Grant, G.; Johnson, S.D.; Smith, D.C.

    1984-08-01

    Solar system components have undergone considerable analysis and evaluation through various efforts such as the Saguaro and Solar 100 design programs and the experimental work conducted by Sandia National Laboratories. While the foregoing work has established the feasibility of molten salt solar plant design, further prototypical testing is necessary prior to the construction of large scale plants. Work is underway on a program to demonstrate the viability of the receiver design, the operation of full size hot and cold salt pumps, and the operability of major salt valves for a commercial solar plant. This work will be undertaken at the Central Receiver Test Facility (CRTF) in Albuquerque.

  11. A 200kW central receiver CPV system

    SciTech Connect

    Lasich, John Thomas, Ian Hertaeg, Wolfgang; Shirley, David; Faragher, Neil; Erenstrom, Neil; Carter, Sam; Cox, Brian; Zuo, Xinyi

    2015-09-28

    Raygen Resources has recently completed a Central Receiver CPV (CSPV) pilot plant in Central Victoria, Australia. The system is under final commissioning and initial operation is expected in late April 2015. The pilot demonstrates a full scale CSPV repeatable unit in a form that is representative of a commercial product and provides a test bed to prove out performance and reliability of the CSPV technology. Extensive testing of the system key components: dense array module, wireless solar powered heliostat and control system has been performed in the laboratory and on sun. Results from this key component testing are presented herein.

  12. A 200kW central receiver CPV system

    NASA Astrophysics Data System (ADS)

    Lasich, John; Thomas, Ian; Hertaeg, Wolfgang; Shirley, David; Faragher, Neil; Erenstrom, Neil; Carter, Sam; Cox, Brian; Zuo, Xinyi

    2015-09-01

    Raygen Resources has recently completed a Central Receiver CPV (CSPV) pilot plant in Central Victoria, Australia. The system is under final commissioning and initial operation is expected in late April 2015. The pilot demonstrates a full scale CSPV repeatable unit in a form that is representative of a commercial product and provides a test bed to prove out performance and reliability of the CSPV technology. Extensive testing of the system key components: dense array module, wireless solar powered heliostat and control system has been performed in the laboratory and on sun. Results from this key component testing are presented herein.

  13. Gaussian mixture models as flux prediction method for central receivers

    NASA Astrophysics Data System (ADS)

    Grobler, Annemarie; Gauché, Paul; Smit, Willie

    2016-05-01

    Flux prediction methods are crucial to the design and operation of central receiver systems. Current methods such as the circular and elliptical (bivariate) Gaussian prediction methods are often used in field layout design and aiming strategies. For experimental or small central receiver systems, the flux profile of a single heliostat often deviates significantly from the circular and elliptical Gaussian models. Therefore a novel method of flux prediction was developed by incorporating the fitting of Gaussian mixture models onto flux profiles produced by flux measurement or ray tracing. A method was also developed to predict the Gaussian mixture model parameters of a single heliostat for a given time using image processing. Recording the predicted parameters in a database ensures that more accurate predictions are made in a shorter time frame.

  14. Solar central receiver reformer system for ammonia plants

    NASA Astrophysics Data System (ADS)

    1980-07-01

    Details of the conceptual design, economic analysis, and development plan for a solar central receiver system for retrofitting the Valley Nitrogen Producers, Inc., El Centro, California 600 ST/SD Ammonia Plant are presented. The retrofit system consists of a solar central receiver reformer (SCRR) operating in parallel with the existing fossil fired reformer. Steam and hydrocarbon react in the catalyst filled tubes of the inner cavity receiver to form a hydrogen rich mixture which is the syngas feed for the ammonia production. The SCRR system displaces natural gas presently used in the fossil reformer combustion chamber. The solar reformer retrofit system characteristics and its interface with the existing plant are simple, incorporating state of the art components with proven technology. A northfield composed of one thousand forty second generation heliostats provides solar energy to the receiver which is positioned on top of a 90 meter high steel tower. The overall economics of this system can provide over 20% discount cash flow rate of return with proper investment and market conditions.

  15. Evaluation of solar-air-heating central-receiver concepts

    SciTech Connect

    Bird, S.P.; Drost, M.K.; Williams, T.A.; Brown, D.R.; Fort, J.A.; Garrett-Price, B.A.; Hauser, S.G.; McLean, M.A.; Paluszek, A.M.; Young, J.K.

    1982-06-01

    The potential of seven proposed air-heating central receiver concepts are evaluated based on an independent, uniform of each one's performance and cost. The concepts include: metal tubes, ceramic tubes, sodium heat pipes, ceramic matrix, ceramic domes, small particles, and volumetric heat exchange. The selection of design points considered in the analysis, the method and ground rules used in formulating the conceptual designs are discussed, and each concept design is briefly described. The method, ground rules, and models used in the performance evaluation and cost analysis and the results are presented. (LEW)

  16. The crustal structure of south central Mongolia using receiver functions

    NASA Astrophysics Data System (ADS)

    He, Jing; Wu, Qingju; Sandvol, Eric; Ni, James; Gallegos, Andrea; Gao, Mengtan; Ulziibat, Munkhuu; Demberel, Sodnomsambuu

    2016-06-01

    The crustal thickness H and average crustal velocity ratio k (Vp/Vs) beneath south central Mongolia are investigated using the H-k stacking method based on teleseismic radial receiver functions. Our primary results reveal that the local crustal thickness varies from 38 to 46 km with an average value of 43 km. Thicker crust is found beneath the western Hentey Mountains, while thinner crust is located in the southern area of the Zuunbayan fault zone. The Bouguer gravity anomalies exhibit a strong correlation with the overall crustal thickness pattern throughout most of our study regime. Moreover, a new approach which integrates the Bouguer anomaly gradient and the receiver function-derived crustal thickness is adopted to calculate the density of the lower crust underneath central Mongolia. Fairly dense lower crust of approximately 3000 kg/m3 is found in the Middle Gobi Desert. The measured crustal Vp/Vs ratio ranges from 1.68 to 1.83 with an average value of 1.74. Low Vp/Vs ratio is found beneath the western Hentey Mountains. In general, low Vp/Vs ratios correlate well with regions of quartz-rich crust and high heat flow. High Vp/Vs ratios occur in the Middle Gobi volcanic regions and the Mesozoic Southern Gobi Basin.

  17. Comparative Performance Assessment For Central Receiver CPV Systems

    NASA Astrophysics Data System (ADS)

    Lasich, John B.; Thomas, Ian; Verlinden, Pierre J.; Lewandowski, Allan; Heartag, Wolfgang; Wright, Mark

    2011-12-01

    A Central receiver Concentrating PV (C2PV) system has the potential to be the optimum solar energy generation system for utility scale because it combines the high efficiency of CPV with the low cost of a heliostat collector. Due to the off axis nature of a heliostat central receiver concentrator a cosine efficiency loss is incurred and, unlike `normal' tracking CPV lens and dish systems, the optical performance varies with time and site latitude. To investigate the optical performance of a C2PV system a ray trace model has been developed and the performance of a representative C2PV system is modelled throughout the year and at different site latitudes. The cosine loss and latitude dependence are put into perspective by calculating the annual average optical efficiency and testing its sensitivity to variations in site latitude. These values are then used to estimate a system performance by applying efficiencies for solar cell, balance of system and operational factors. This system efficiency is finally compared to published data for `normal' tracking CPV dish and lens systems. Modelled annual average AC system efficiency for the C2PV system was calculated to be 21% at 40° latitude and 19% at 15° latitude. These annual average AC system efficiencies are shown to be similar to those reported for typical dish and lens CPV systems when they are adjusted to use a total collector area baseline.

  18. QPSK loop lock detection in the advanced receiver

    NASA Technical Reports Server (NTRS)

    Mileant, A.; Hinedi, S.

    1990-01-01

    The Advanced Receiver (ARX 2) currently being developed uses a Costas crossover loop to acquire and track the phase of an incoming quadrature phase-shift-keyed (QPSK) signal. The performance is described for the QPSK lock detector to be implemented, taking into account the phase jitter in the tracking loop. Simulations are used to verify the results of the analysis.

  19. QPSK loop lock detection in the advanced receiver

    NASA Astrophysics Data System (ADS)

    Mileant, A.; Hinedi, S.

    1990-05-01

    The Advanced Receiver (ARX 2) currently being developed uses a Costas crossover loop to acquire and track the phase of an incoming quadrature phase-shift-keyed (QPSK) signal. The performance is described for the QPSK lock detector to be implemented, taking into account the phase jitter in the tracking loop. Simulations are used to verify the results of the analysis.

  20. Large-scale use of solar energy with central receivers

    NASA Astrophysics Data System (ADS)

    Kreith, F.; Meyer, R. T.

    1983-12-01

    The working principles of solar central receiver power plants are outlined and applications are discussed. Heliostat arrays direct sunlight into a receiver cavity mounted on a tower, heating the working fluid in the tower to temperatures exceeding 500 C. The formulation for the image plane and the geometric concentration ratio for a heliostat field are provided, noting that commercial electric power plants will require concentration ratios of 200-1000. Automated controls consider imperfections in the mirrors, tracking errors, and seasonal insolation intensity and angular variations. Membranes may be used instead of rigid heliostat mirrors to reduce costs, while trade-offs exist between the efficiencies of cavity and exterior receivers on the tower. Sensible heat storage has proved most effective for cloudy or nighttime operations. Details of the DOE Solar One 10 MW plant, which began operation in 1982, are provided, with mention given to the 33.6 continuous hours of power generation that have been achieved. Projected costs of commercial installations are $700/kWt, and possible applications include recovering and refining oil, processing natural gas, uranium ore, and sugar cane, drying gypsum board, and manufacturing ammonia.

  1. Solar Central Receiver Hybrid Power Systems sodium-cooled receiver concept. Final report. Volume III. Appendices

    SciTech Connect

    1980-01-01

    The overall, long term objective of the Solar Central Receiver Hybrid Power System is to identify, characterize, and ultimately demonstrate the viability and cost effectiveness of solar/fossil, steam Rankine cycle, hybrid power systems that: (1) consist of a combined solar central receiver energy source and a nonsolar energy source at a single, common site, (2) may operate in the base, intermediate, and peaking capacity modes, (3) produce the rated output independent of variations in solar insolation, (4) provide a significant savings (50% or more) in fuel consumpton, and (5) produce power at the minimum possible cost in mills/kWh. It is essential that these hybrid concepts be technically feasible and economically competitive with other systems in the near to mid-term time period (1985-1990) on a commercial scale. The program objective for Phase I is to identify and conceptually characterize solar/fossil steam Rankine cycle, commercial-scale, power plant systems that are economically viable and technically feasible. This volume contains appendices to the conceptual design and systems analysis studies gien in Volume II, Books 1 and 2. (WHK)

  2. Crustal Seismic Structure of Central Alberta from Receiver Function Inversions

    NASA Astrophysics Data System (ADS)

    Chen, Y.; Dokht, R.; Gu, Y. J.; Sacchi, M. D.

    2013-12-01

    It is widely believed that the basement structure of central Alberta represents the tectonic assembly and evolution of several Archean lithospheric fragments. These fragments underwent episodes of rifting, collision, subduction and melting during the Proterozoic, giving rise to a complex network of tectonic domains with considerable differences in the crustal magnetic and seismic signatures. Observational support for these episodes, e.g., the coeval subduction around the Hearne province, has been limited due to the lack of exposed geology and insufficient teleseismic data prior to 2006. Since mid 2007, the establishment of the Canadian Rockies and Alberta Network (CRANE) has greatly improved the broadband seismic data coverage in central and southern Alberta. Based on 5+ years of CRANE data, we systematically analyze crust and shallow mantle shear velocities through simultaneous inversions of low and high frequency receiver functions. P-to-S converted waves from several stations in central Alberta suggest a significant mid crustal low velocity zone (LVZ), where shear velocity could vary by as much as 35 percent in a depth range of 15-35 km. This structure is not required by the receiver functions from stations along the foothills of the Rocky Mountains. While LVZ of notable magnitudes have been suggested previously in an overlapped part of the study region and attributed to the presence of serpentine or intrusive sill, the spatial dimensions of the anomaly reported in the current study is significantly larger: this anomaly spans hundreds of kilometers horizontally and is generally thicker than 10 km. The presence of mid/lower crustal LVZ in central Alberta is supported by recent group velocity maps based on noise correlation tomography, and the southeastward orientation of this LVZ is consistent with the proposed direction of the subducted oceanic microplate beneath the northwestern Hearne province during the Proterozoic. Still, the cause of the LVZ remains

  3. Central Andean crustal structure from receiver function analysis

    NASA Astrophysics Data System (ADS)

    Ryan, Jamie; Beck, Susan; Zandt, George; Wagner, Lara; Minaya, Estela; Tavera, Hernado

    2016-07-01

    The Central Andean Plateau (15°-27°S) is a high plateau in excess of 3 km elevation, associated with thickened crust along the western edge of the South America plate, in the convergent margin between the subducting Nazca plate and the Brazilian craton. We have calculated receiver functions using seismic data from a recent portable deployment of broadband seismometers in the Bolivian orocline (12°-21°S) region and combined them with waveforms from 38 other stations in the region to investigate crustal thickness and crust and mantle structures. Results from the receiver functions provide a more detailed map of crustal thickness than previously existed, and highlight mid-crustal features that match well with prior studies. The active volcanic arc and Altiplano have thick crust with Moho depths increasing from the central Altiplano (65 km) to the northern Altiplano (75 km). The Eastern Cordillera shows large along strike variations in crustal thickness. Along a densely sampled SW-NE profile through the Bolivian orocline there is a small region of thin crust beneath the high peaks of the Cordillera Real where the average elevations are near 4 km, and the Moho depth varies from 55 to 60 km, implying the crust is undercompensated by ~ 5 km. In comparison, a broader region of high elevations in the Eastern Cordillera to the southeast near ~ 20°S has a deeper Moho at ~ 65-70 km and appears close to isostatic equilibrium at the Moho. Assuming the modern-day pattern of high precipitation on the flanks of the Andean plateau has existed since the late Miocene, we suggest that climate induced exhumation can explain some of the variations in present day crustal structure across the Bolivian orocline. We also suggest that south of the orocline at ~ 20°S, the thicker and isostatically compensated crust is due to the absence of erosional exhumation and the occurrence of lithospheric delamination.

  4. The advanced receiver 2: Telemetry test results in CTA 21

    NASA Technical Reports Server (NTRS)

    Hinedi, S.; Bevan, R.; Marina, M.

    1991-01-01

    Telemetry tests with the Advanced Receiver II (ARX II) in Compatibility Test Area 21 are described. The ARX II was operated in parallel with a Block-III Receiver/baseband processor assembly combination (BLK-III/BPA) and a Block III Receiver/subcarrier demodulation assembly/symbol synchronization assembly combination (BLK-III/SDA/SSA). The telemetry simulator assembly provided the test signal for all three configurations, and the symbol signal to noise ratio as well as the symbol error rates were measured and compared. Furthermore, bit error rates were also measured by the system performance test computer for all three systems. Results indicate that the ARX-II telemetry performance is comparable and sometimes superior to the BLK-III/BPA and BLK-III/SDA/SSA combinations.

  5. Advanced laser sensing receiver concepts based on FPA technology.

    SciTech Connect

    Jacobson, P. L.; Petrin, R. R.; Jolin, J. L.; Foy, B. R.; Lowrance, J. L.; Renda, G.

    2002-01-01

    The ultimate performance of any remote sensor is ideally governed by the hardware signal-to-noise capability and allowed signal-averaging time. In real-world scenarios, this may not be realizable and the limiting factors may suggest the need for more advanced capabilities. Moving from passive to active remote sensors offers the advantage of control over the illumination source, the laser. Added capabilities may include polarization discrimination, instantaneous imaging, range resolution, simultaneous multi-spectral measurement, or coherent detection. However, most advanced detection technology has been engineered heavily towards the straightforward passive sensor requirements, measuring an integrated photon flux. The need for focal plane array technology designed specifically for laser sensing has been recognized for some time, but advances have only recently made the engineering possible. This paper will present a few concepts for laser sensing receiver architectures, the driving specifications behind those concepts, and test/modeling results of such designs.

  6. Advanced Receiver/Converter Experiments for Laser Wireless Power Transmission

    NASA Technical Reports Server (NTRS)

    Howell, Joe T.; ONeill, Mark; Fork, Richard

    2004-01-01

    For several years NASA Marshall Space Flight Center, UAH and ENTECH have been working on various aspects of space solar power systems. The current activity was just begun in January 2004 to further develop this new photovoltaic concentrator laser receiver/converter technology. During the next few months, an improved prototype will be designed, fabricated, and thoroughly tested under laser illumination. The final paper will describe the new concept, present its advantages over other laser receiver/converter approaches (including planar photovoltaic arrays), and provide the latest experiment results on prototype hardware (including the effects of laser irradiance level and cell temperature). With NASA's new human exploration plans to first return to the Moon, and then to proceed to Mars, the new photovoltaic concentrator laser receiver/converter technology could prove to be extremely useful in providing power to the landing sites and other phases of the missions. For example, to explore the scientifically interesting and likely resource-rich poles of the Moon (which may contain water) or the poles of Mars (which definitely contain water and carbon dioxide), laser power beaming could represent the simplest means of providing power to these regions, which receive little or no sunlight, making solar arrays useless there. In summary, the authors propose a paper on definition and experimental results of a novel photovoltaic concentrator approach for collecting and converting laser radiation to electrical power. The new advanced photovoltaic concentrator laser receiver/converter offers higher performance, lighter weight, and lower cost than competing concepts, and early experimental results are confirming the expected excellent Performance levels. After the small prototypes are successfully demonstrated, a larger array with even better performance is planned for the next phase experiments and demonstrations. Thereafter, a near-term flight experiment of the new technology

  7. Characterization of Advanced Avalanche Photodiodes for Water Vapor Lidar Receivers

    NASA Technical Reports Server (NTRS)

    Refaat, Tamer F.; Halama, Gary E.; DeYoung, Russell J.

    2000-01-01

    Development of advanced differential absorption lidar (DIAL) receivers is very important to increase the accuracy of atmospheric water vapor measurements. A major component of such receivers is the optical detector. In the near-infrared wavelength range avalanche photodiodes (APD's) are the best choice for higher signal-to-noise ratio, where there are many water vapor absorption lines. In this study, characterization experiments were performed to evaluate a group of silicon-based APD's. The APD's have different structures representative of different manufacturers. The experiments include setups to calibrate these devices, as well as characterization of the effects of voltage bias and temperature on the responsivity, surface scans, noise measurements, and frequency response measurements. For each experiment, the setup, procedure, data analysis, and results are given and discussed. This research was done to choose a suitable APD detector for the development of an advanced atmospheric water vapor differential absorption lidar detection system operating either at 720, 820, or 940 nm. The results point out the benefits of using the super low ionization ratio (SLIK) structure APD for its lower noise-equivalent power, which was found to be on the order of 2 to 4 fW/Hz(sup (1/2)), with an appropriate optical system and electronics. The water vapor detection systems signal-to-noise ratio will increase by a factor of 10.

  8. Norwich Technologies' Advanced Low-Cost Receivers for Parabolic Troughs

    SciTech Connect

    Stettenheim, Joel; McBride, Troy O.; Brambles, Oliver J.; Cashin, Emil A.

    2013-12-31

    This report summarizes the successful results of our SunShot project, Advanced Low-Cost Receivers for Parabolic Troughs. With a limited budget of $252K and in only 12 months, we have (1) developed validated optical and thermal models and completed rigorous optimization analysis to identify key performance characteristics as part of developing first-generation laboratory prototype designs, (2) built optical and thermal laboratory prototypes and test systems with associated innovative testing protocols, and (3) performed extensive statistically relevant testing. We have produced fully functioning optical and thermal prototypes and accurate, validated models shown to capture important underlying physical mechanisms. The test results from the first-generation prototype establish performance exceeding the FOA requirement of thermal efficiency >90% for a CSP receiver while delivering an exit fluid temperature of > 650 °C and a cost < $150/kWth. Our vacuum-free SunTrap receiver design provides improvements over conventional vacuum-tube collectors, allowing dramatic reductions in thermal losses at high operating temperature.

  9. Concentrating Solar Power Central Receiver Panel Component Fabrication and Testing FINAL REPORT

    SciTech Connect

    McDowell, Michael W; Miner, Kris

    2013-03-30

    The objective of this project is to complete a design of an advanced concentrated solar panel and demonstrate the manufacturability of key components. Then confirm the operation of the key components under prototypic solar flux conditions. This work is an important step in reducing the levelized cost of energy (LCOE) from a central receiver solar power plant. The key technical risk to building larger power towers is building the larger receiver systems. Therefore, this proposed technology project includes the design of an advanced molten salt prototypic sub-scale receiver panel that can be utilized into a large receiver system. Then complete the fabrication and testing of key components of the receive design that will be used to validate the design. This project shall have a significant impact on solar thermal power plant design. Receiver panels of suitable size for utility scale plants are a key element to a solar power tower plant. Many subtle and complex manufacturing processes are involved in producing a reliable, robust receiver panel. Given the substantial size difference between receiver panels manufactured in the past and those needed for large plant designs, the manufacture and demonstration on prototype receiver panel components with representative features of a full-sized panel will be important to improving the build process for commercial success. Given the thermal flux limitations of the test facility, the panel components cannot be rendered full size. Significance changes occurred in the projects technical strategies from project initiation to the accomplishments described herein. The initial strategy was to define cost improvements for the receiver, design and build a scale prototype receiver and test, on sun, with a molten salt heat transport system. DOE had committed to constructing a molten salt heat transport loop to support receiver testing at the top of the NSTTF tower. Because of funding constraints this did not happen. A subsequent plan to

  10. Advances in Primary Central Nervous System Lymphoma.

    PubMed

    Patrick, Lauren B; Mohile, Nimish A

    2015-12-01

    Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma that is limited to the CNS. Although novel imaging techniques aid in discriminating lymphoma from other brain tumors, definitive diagnosis requires brain biopsy, vitreoretinal biopsy, or cerebrospinal fluid analysis. Survival rates in clinical studies have improved over the past 20 years due to the addition of high-dose methotrexate-based chemotherapy regimens to whole-brain radiotherapy. Long-term survival, however, is complicated by clinically devastating delayed neurotoxicity. Newer regimens are attempting to reduce or eliminate radiotherapy from first-line treatment with chemotherapy dose intensification. Significant advances have also been made in the fields of pathobiology and treatment, with more targeted treatments on the horizon. The rarity of the disease makes conducting of prospective clinical trials challenging, requiring collaborative efforts between institutions. This review highlights recent advances in the biology, detection, and treatment of PCNSL in immunocompetent patients.

  11. Advances in Primary Central Nervous System Lymphoma.

    PubMed

    Patrick, Lauren B; Mohile, Nimish A

    2015-12-01

    Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma that is limited to the CNS. Although novel imaging techniques aid in discriminating lymphoma from other brain tumors, definitive diagnosis requires brain biopsy, vitreoretinal biopsy, or cerebrospinal fluid analysis. Survival rates in clinical studies have improved over the past 20 years due to the addition of high-dose methotrexate-based chemotherapy regimens to whole-brain radiotherapy. Long-term survival, however, is complicated by clinically devastating delayed neurotoxicity. Newer regimens are attempting to reduce or eliminate radiotherapy from first-line treatment with chemotherapy dose intensification. Significant advances have also been made in the fields of pathobiology and treatment, with more targeted treatments on the horizon. The rarity of the disease makes conducting of prospective clinical trials challenging, requiring collaborative efforts between institutions. This review highlights recent advances in the biology, detection, and treatment of PCNSL in immunocompetent patients. PMID:26475775

  12. QPSK carrier-acquisition performance in the advanced receiver 2

    NASA Astrophysics Data System (ADS)

    Hinedi, S.; Shah, B.

    1990-02-01

    The frequency-acquisition performance of the Costas cross-over loop which is used in the Advanced Receiver 2 (ARX 2) to perform Quadrature Phase Shift Keying (QPSK) carrier tracking is described. The performance of the Costas cross-over loop is compared to two other QPSK carrier tracking loops: the MAP estimation loop and the generalized Costas loop. Acquisition times and probabilities of acquisition as functions of both loop signal-to-noise ratio and frequency-offset to loop-bandwidth ratio are obtained using computer simulations for both type-2 and type-3 loops. It is shown that even though the MAP loop results in the smallest squaring loss for all signal-to-noise ratios, the MAP loop is sometimes outperformed by the other two loops in terms of acquisition time and probability.

  13. QPSK carrier-acquisition performance in the advanced receiver 2

    NASA Technical Reports Server (NTRS)

    Hinedi, S.; Shah, B.

    1990-01-01

    The frequency-acquisition performance of the Costas cross-over loop which is used in the Advanced Receiver 2 (ARX 2) to perform Quadrature Phase Shift Keying (QPSK) carrier tracking is described. The performance of the Costas cross-over loop is compared to two other QPSK carrier tracking loops: the MAP estimation loop and the generalized Costas loop. Acquisition times and probabilities of acquisition as functions of both loop signal-to-noise ratio and frequency-offset to loop-bandwidth ratio are obtained using computer simulations for both type-2 and type-3 loops. It is shown that even though the MAP loop results in the smallest squaring loss for all signal-to-noise ratios, the MAP loop is sometimes outperformed by the other two loops in terms of acquisition time and probability.

  14. Costas loop lock detection in the advanced receiver

    NASA Astrophysics Data System (ADS)

    Mileant, A.; Hinedi, S.

    1989-11-01

    The advanced receiver currently being developed uses a Costas digital loop to demodulate the subcarrier. Previous analyses of lock detector algorithms for Costas loops have ignored the effects of the inherent correlation between the samples of the phase-error process. Accounting for this correlation is necessary to achieve the desired lock-detection probability for a given false-alarm rate. Both analysis and simulations are used to quantify the effects of phase correlation on lock detection for the square-law and the absolute-value type detectors. Results are obtained which depict the lock-detection probability as a function of loop signal-to-noise ratio for a given false-alarm rate. The mathematical model and computer simulation show that the square-law detector experiences less degradation due to phase jitter than the absolute-value detector and that the degradation in detector signal-to-noise ratio is more pronounced for square-wave than for sine-wave signals.

  15. Costas loop lock detection in the advanced receiver

    NASA Technical Reports Server (NTRS)

    Mileant, A.; Hinedi, S.

    1989-01-01

    The advanced receiver currently being developed uses a Costas digital loop to demodulate the subcarrier. Previous analyses of lock detector algorithms for Costas loops have ignored the effects of the inherent correlation between the samples of the phase-error process. Accounting for this correlation is necessary to achieve the desired lock-detection probability for a given false-alarm rate. Both analysis and simulations are used to quantify the effects of phase correlation on lock detection for the square-law and the absolute-value type detectors. Results are obtained which depict the lock-detection probability as a function of loop signal-to-noise ratio for a given false-alarm rate. The mathematical model and computer simulation show that the square-law detector experiences less degradation due to phase jitter than the absolute-value detector and that the degradation in detector signal-to-noise ratio is more pronounced for square-wave than for sine-wave signals.

  16. Low-profile heliostat design for solar central receiver systems

    NASA Technical Reports Server (NTRS)

    Fourakis, E.; Severson, A. M.

    1977-01-01

    Heliostat designs intended to reduce costs and the effect of adverse wind loads on the devices were developed. Included was the low-profile heliostat consisting of a stiff frame with sectional focusing reflectors coupled together to turn as a unit. The entire frame is arranged to turn angularly about a center point. The ability of the heliostat to rotate about both the vertical and horizontal axes permits a central computer control system to continuously aim the sun's reflection onto a selected target. An engineering model of the basic device was built and is being tested. Control and mirror parameters, such as roughness and need for fine aiming, are being studied. The fabrication of these prototypes is in process. The model was also designed to test mirror focusing techniques, heliostat geometry, mechanical functioning, and tracking control. The model can be easily relocated to test mirror imaging on a tower from various directions. In addition to steering and aiming studies, the tests include the effects of temperature changes, wind gusting and weathering. The results of economic studies on this heliostat are also presented.

  17. Effect of High Receiver Thermal Loss Per Unit Area on the Performance of Solar Central Receiver Systems Having Optimum Heliostat Fields and Optimum Receiver Aperture Areas.

    NASA Astrophysics Data System (ADS)

    Pitman, Charles L.

    Recent efforts in solar central receiver research have been directed toward high temperature applications. Associated with high temperature processes are greater receiver thermal losses due to reradiation and convection. This dissertation examines the performance of central receiver systems having optimum heliostate fields and receiver aperture areas as a function of receiver thermal loss per unit area of receiver aperture. The results address the problem of application optimization (loss varies) as opposed to the problem of optimization of a design for a specific application (loss fixed). A reasonable range of values for the primary independent variable L (the average reradiative and convective loss per unit area of receiver aperture) and a reasonable set of design assumptions were first established. The optimum receiver aperture area, number and spacings of heliostats, and field boundary were then determined for two tower focal heights and for each value of L. From this, the solar subsystem performance for each optimized system was calculated. Heliostat field analysis and optimization required a detailed computational analysis. A significant modification to the standard method of solving the optimization equations, effectively a decoupling of the solution process into collector and receiver subsystem parts, greatly aided the analysis. Results are presented for tower focal heights of 150 and 180 m. Values of L ranging from 0.04 to 0.50 MW m('-2) were considered, roughly corresponding to working fluid temperatures (at receiver exit) in the range of 650 to 1650 C. As L increases over this range, the receiver thermal efficiency and the receiver interception factor decrease. The optimal power level drops by almost half, and the cost per unit of energy produced increases by about 25% for the base case set of design assumptions. The resulting decrease in solar subsystem efficiency (relative to the defined annual input energy) from 0.57 to 0.35 is about 40% and is a

  18. Advanced sensible heat solar receiver for space power

    NASA Technical Reports Server (NTRS)

    Bennett, Timothy J.; Lacy, Dovie E.

    1988-01-01

    NASA Lewis, through in-house efforts, has begun a study to generate a conceptual design of a sensible heat solar receiver and to determine the feasibility of such a system for space power applications. The sensible heat solar receiver generated in this study uses pure lithium as the thermal storage medium and was designed for a 7 kWe Brayton (PCS) operating at 1100 K. The receiver consists of two stages interconnected via temperature sensing variable conductance sodium heat pipes. The lithium is contained within a niobium vessel and the outer shell of the receiver is constructed of third generation rigid, fibrous ceramic insulation material. Reradiation losses are controlled with niobium and aluminum shields. By nature of design, the sensible heat receiver generated in this study is comparable in both size and mass to a latent heat system of similar thermal capacitance. The heat receiver design and thermal analysis was conducted through the combined use of PATRAN, SINDA, TRASYS, and NASTRAN software packages.

  19. Advanced sensible heat solar receiver for space power

    NASA Technical Reports Server (NTRS)

    Bennett, Timothy J.; Lacy, Dovie E.

    1988-01-01

    NASA Lewis, through in-house efforts, has begun a study to generate a conceptual design of a sensible heat solar receiver and to determine the feasibility of such a system for space power applications. The sensible heat solar receiver generated in this study uses pure lithium as the thermal storage medium and was designed for a 7 kWe Brayton (PCS) operating at 1100 K. The receiver consists of two stages interconnected via temperature sensing variable conductance sodium heat pipes. The lithium is contained within a niobium vessel and the outer shell of the receiver is constructed of third generation rigid, fibrous ceramic insulation material. Reradiation losses are controlled with niobium and aluminum shields. By nature of design, the sensible heat receiver generated in this study is comparable in both size and mass to a latent heat system of similar thermal capacitance. The heat receiver design and thermal analysis were conducted through the combined use of PATRAN, SINDA, TRASYS, and NASTRAN software packages.

  20. Advanced development receiver thermal vacuum tests with cold wall

    NASA Technical Reports Server (NTRS)

    Sedgwick, Leigh M.

    1991-01-01

    The first ever testing of a full size solar dynamic heat receiver using high temperature thermal energy storage was completed. The heat receiver was designed to meet the requirements for operation on the Space Station Freedom. The purpose of the test program was to quantify the receiver thermodynamic performance, its operating temperatures, and thermal response to changes in environmental and power module interface boundary conditions. The heat receiver was tested in a vacuum chamber with liquid nitrogen cold shrouds and an aperture cold plate to partially simulate a low Earth orbit environment. The cavity of the receiver was heated by an infrared quartz lamp heater with 30 independently controllable zones to produce flux distributions typical of candidate concentrators. A closed Brayton cycle engine simulator conditioned a helium xenon gas mixture to specific interface conditions to simulate various operational modes of the solar dynamic power module. Inlet gas temperature, pressure, and flow rate were independently varied. A total of 58 simulated orbital cycles were completed during the test conduct period. The test hardware, execution of testing, test data, and post test inspections are described.

  1. Tri-Lateral Noor al Salaam High Concentration Solar Central Receiver Program

    SciTech Connect

    Blackmon, James B

    2008-03-31

    This report documents the efforts conducted primarily under the Noor al Salaam (“Light of Peace”) program under DOE GRANT NUMBER DE-FC36-02GO12030, together with relevant technical results from a closely related technology development effort, the U.S./Israel Science and Technology Foundation (USISTF) High Concentration Solar Central Receiver program. These efforts involved preliminary design, development, and test of selected prototype power production subsystems and documentation of an initial version of the system definition for a high concentration solar hybrid/gas electrical power plant to be built in Zaafarana, Egypt as a first step in planned commercialization. A major part of the planned work was halted in 2007 with an amendment in October 2007 requiring that we complete the technical effort by December 31, 2007 and provide a final report to DOE within the following 90 days. This document summarizes the work conducted. The USISTF program was a 50/50 cost-shared program supported by the Department of Commerce through the U.S./Israel Science and Technology Commission (USISTC). The USISTC was cooperatively developed by President Clinton and the late Prime Minister Rabin of Israel "to encourage technological collaboration" and "support peace in the Middle East through economic development". The program was conducted as a follow-on effort to Israel's Magnet/CONSOLAR Program, which was an advanced development effort to design, fabricate, and test a solar central receiver and secondary optics for a "beam down" central receiver concept. The status of these hardware development programs is reviewed, since they form the basis for the Noor al Salaam program. Descriptions are provided of the integrated system and the major subsystems, including the heliostat, the high temperature air receiver, the power conversion unit, tower and tower reflector, compound parabolic concentrator, and the master control system. One objective of the USISTF program was to conduct

  2. Investigation of cold filling receiver panels and piping in molten-nitrate-salt central-receiver solar power plants

    SciTech Connect

    Pacheco, J.E.; Ralph, M.E.; Chavez, J.M.

    1994-12-31

    Cold filling refers to flowing a fluid through piping or tubes that are at temperatures below the fluid`s freezing point. Since the piping and areas of the receiver in a molten-nitrate salt central-receiver solar power plant must be electrically heated to maintain their temperatures above the nitrate salt freezing point (430{degrees}F, 221{degrees}C), considerable energy could be used to maintain such temperatures during nightly shut down and bad weather. Experiments and analyses have been conducted to investigate cold filling receiver panels and piping as a way of reducing parasitic electrical power consumption and increasing the availability of the plant. The two major concerns with cold filling are: (1) how far can the molten salt penetrate cold piping before freezing closed and (2) what thermal stresses develop during the associated thermal shock. Cold fill experiments were conducted by flowing molten salt at 550{degrees}F (288{degrees}C) through cold panels, manifolds, and piping to determine the feasibility of cold filling the receiver and piping. The transient thermal responses were measured and heat transfer coefficients were calculated from the data. Nondimensional analysis is presented which quantifies the thermal stresses in a pipe or tube undergoing thermal shock. In addition, penetration distances were calculated to determine the distance salt could flow in cold pipes prior to freezing closed.

  3. 75 FR 38151 - Governors' Designees Receiving Advance Notification of Transportation of Nuclear Waste

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... COMMISSION Governors' Designees Receiving Advance Notification of Transportation of Nuclear Waste On January... prior to transportation of certain shipments of nuclear waste and spent fuel. The advance notification... numbers of those individuals in each State who are responsible for receiving information on nuclear...

  4. Review of the Molten Salt Electric Experiment: A solar central receiver project

    SciTech Connect

    Delameter, W.R.; Bergan, N.E.

    1986-12-01

    The Molten Salt Electric Experiment was the first full solar-to-electric central receiver system to use molten nitrate salt as a primary working fluid. The experiment was built and tested at the Central Receiver Test Facility in Albuquerque, New Mexico, between 1982 and 1985. The purpose of the project was to demonstrate the technical feasibility of a molten salt central receiver system. The Molten Salt Electric Experiment was operated through a year of successful testing; system performance was measured, operating procedures and an effective receiver control algorithm were developed, and personnel from participating electrical utilities and solar industries were trained to operate the system. The testing culminated in a one-month power production campaign to measure daily performance, component reliability, and system availability. This paper discusses the major accomplishments and some of the more significant problems of the project.

  5. Solar power tower design guide: Solar thermal central receiver power systems. A source of electricity and/or process heat

    NASA Astrophysics Data System (ADS)

    Battleson, K. W.

    1981-04-01

    Preliminary evaluations of whether a solar thermal central receiver plant is technically and economically feasible and desirable, for the potential user's application are reported. The cost elements, performance, and operation of solar central receiver systems are described.

  6. Impact of Aerosols on Atmospheric Attenuation Loss in Central Receiver Systems: Preprint

    SciTech Connect

    Sengupta, M.; Wagner, M. J.

    2011-08-01

    Atmospheric attenuation loss between the heliostat field and receiver has been recognized as a significant source of loss in Central Receiver Systems. In clear sky situations, extinction of Direct Normal Irradiance (DNI) is primarily by aerosols in the atmosphere. When aerosol loading is high close to the surface the attenuation loss between heliostat and receivers is significantly influenced by the amount of aerosols present on a particular day. This study relates measured DNI to aerosol optical depths close to the surface of the earth. The model developed in the paper uses only measured DNI to estimate the attenuation between heliostat and receiver in a central receiver system. The requirement that only a DNI measurement is available potentially makes the model a candidate for widespread use.

  7. The development of an advanced generic solar dynamic heat receiver thermal model

    NASA Technical Reports Server (NTRS)

    Wu, Y. C.; Roschke, E. J.; Kohout, L.

    1988-01-01

    An advanced generic solar dynamic heat receiver thermal model under development which can analyze both orbital transient and orbital average conditions is discussed. This model can be used to study advanced receiver concepts, evaluate receiver concepts under development, analyze receiver thermal characteristics under various operational conditions, and evaluate solar dynamic system thermal performances in various orbit conditions. The model and the basic considerations that led to its creation are described, and results based on a set of baseline orbit, configuration, and operational conditions are presented to demonstrate the working of the receiver model.

  8. Assessment of molten-salt solar central-receiver freeze-up and recovery events

    SciTech Connect

    Pacheco, J.E.; Dunkin, S.R.

    1996-02-01

    Molten salt used as a heat transfer fluid in central-receiver so ar power plants has a high freezing point (430{degrees}F (221{degrees}C)). It is very likely during the life of the plant that the receiver will accidentally freeze up due to equipment malfunction or operator error. Experiments were conducted to measure the effects of a molten salt receiver freeze-up and recovery event and methods to thaw the receiver. In addition, simulated freeze/thaw experiments were conducted to determine what happens when salt freezes and is thawed in receiver tubes and to quantify the damage caused to candidate receiver tube materials. Fourteen tube samples of various materials, diameters and wall thicknesses were tested to destruction. Results of these tests are presented in this paper.

  9. Recent advances in central congenital hypothyroidism

    PubMed Central

    Schoenmakers, Nadia; Alatzoglou, Kyriaki S; Chatterjee, V Krishna; Dattani, Mehul T

    2015-01-01

    Central congenital hypothyroidism (CCH) may occur in isolation, or more frequently in combination with additional pituitary hormone deficits with or without associated extrapituitary abnormalities. Although uncommon, it may be more prevalent than previously thought, affecting up to 1:16 000 neonates in the Netherlands. Since TSH is not elevated, CCH will evade diagnosis in primary, TSH-based, CH screening programs and delayed detection may result in neurodevelopmental delay due to untreated neonatal hypothyroidism. Alternatively, coexisting growth hormones or ACTH deficiency may pose additional risks, such as life threatening hypoglycaemia. Genetic ascertainment is possible in a minority of cases and reveals mutations in genes controlling the TSH biosynthetic pathway (TSHB, TRHR, IGSF1) in isolated TSH deficiency, or early (HESX1, LHX3, LHX4, SOX3, OTX2) or late (PROP1, POU1F1) pituitary transcription factors in combined hormone deficits. Since TSH cannot be used as an indicator of euthyroidism, adequacy of treatment can be difficult to monitor due to a paucity of alternative biomarkers. This review will summarize the normal physiology of pituitary development and the hypothalamic–pituitary–thyroid axis, then describe known genetic causes of isolated central hypothyroidism and combined pituitary hormone deficits associated with TSH deficiency. Difficulties in diagnosis and management of these conditions will then be discussed. PMID:26416826

  10. 3 CFR - Eligibility of the Economic Community of Central African States To Receive Defense Articles and...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of State Pursuant to the authority vested in me by the Constitution and the laws of the United States... services to the Economic Community of Central African States will strengthen the security of the United... African States To Receive Defense Articles and Defense......

  11. Advanced heat receiver conceptual design study. Final report, May 1986-July 1988

    SciTech Connect

    Kesseli, J.; Saunders, R.; Batchelder, G.

    1988-10-01

    Solar dynamic space power systems are candidate electrical power generating systems for future NASA missions. One of the key components of the solar dynamic power system is the solar receiver/thermal energy storage (TES) subsystem. Receiver development was conducted by NASA in the late 1960's and since then a very limited amount of work has been done in this area. Consequently the state of the art (SOA) receivers designed for the IOC space station are large and massive. The objective of the Advanced Heat Receiver Conceptual Design Study is to conceive and analyze advanced high temperature solar dynamic Brayton and Stirling receivers. The goal is to generate innovative receiver concepts that are half of the mass, smaller, and more efficient than the SOA. It is also necessary that these innovative receivers offer ease of manufacturing, less structural complexity and fewer thermal stress problems. Advanced Brayton and Stirling receiver storage units are proposed and analyzed in this study which can potentially meet these goals.

  12. An LQ-solution to a control problem associated with a solar thermal central receiver

    NASA Astrophysics Data System (ADS)

    Sworder, D. D.; Rogers, R. O.

    1983-10-01

    The linearized process dynamics of the steam boiler in a solar-powered central receiver change abruptly when clouds interfere with the sun's rays. The steam temperature regulator used to maintain proper exit steam conditions must control a system with variable structure and discontinuous state trajectories. This paper investigates the quadratic-optimal control of such a system, and gives the design equations for the optimal regulator.

  13. Telemetry SNR improvement using the DSN Advanced Receiver with results for Pioneer 10

    NASA Technical Reports Server (NTRS)

    Hurd, W. J.; Brown, D. H.; Vilnrotter, V. A.; Wiggins, J. D.

    1988-01-01

    A series of tracking tests was conducted in the spring of 1987 to demonstrate the reduced tracking threshold and the improved telemetry singal-to-noise-ratio performance of the DSN Advanced Receiver compared to current operational DSN systems. The Pioneer 10 spacecraft, which is now out of the solar system, was tracked on foud days. The Advanced Receiver achieved an improvement in telemetry SNR of 1 to 1.5 dB over the operational system. It was demonstrated that the spacecraft carrier signal is stable enough for tracking with a receiver carrier loop bandwidth of 0.5 Hz in the one-way mode and 0.1 Hz in the three-way mode, and that the Advanced Receiver is stable at 0.1 Hz. This reduces tracking threshold by 10 to 15 dB compared to current receivers, which have minimum loop bandwidths of 1 to 3 Hz. Thus, the Advanced Receiver will enable tracking of the Pioneer 10 spacecraft until its power source fails, circa 2000, which would not be possible with the current DSN system.

  14. The Crustal Structure of the Central Anatolia (Turkey) Using Receiver Functions

    NASA Astrophysics Data System (ADS)

    Yelkenci, S.; Benoit, M.; Kuleli, H.; Gurbuz, C.

    2005-12-01

    Central Anatolia lies in a transitional region between the extensional tectonics of western Anatolia and the complex transpressional tectonics of Eastern Anatolia, and has a complicated thermal and structural history. Few studies of the crustal structure of Anatolia have been performed, however, studies of the crustal structure of Eastern Anatolia showed that crustal thicknesses were thinner than previously thought. To further investigate the crustal structure in Central Anatolia, we present results from receiver function analysis using new data from broad-band instruments. The stations were equipped with 7 broadband three-component STS-2 and 13 short period three-component S-13 sensors. These stations operated for period of one and half months between the October and November, 2002, and yielded data for ~ 40 high quality receiver functions. Additionally, receiver functions were also computed using data from permanent stations MALT, ISP, and ANTO. We applied the hk-stacking technique of Zhu and Kanamori (2000) to receiver functions to obtain the crustal thickness and Vp/Vs ratios. Furthermore, we applied a waveform modeling technique to investigate mid-crustal discontinuties previously imaged in the region. Our results compare well with refraction-based crustal thicknesses in overlapped areas.

  15. Preliminary design of a solar central receiver for site-specific repowering application (Saguaro Power Plant). Volume II. Preliminary design. Final report, October 1982-September 1983

    SciTech Connect

    Weber, E.R.

    1983-09-01

    The solar central receiver technology, site, and specific unit for repowering were selected in prior analyses and studies. The objectives of this preliminary design study were to: develop a solar central receiver repowering design for Saguaro that (1) has potential to be economically competitive with fossil fueled plants in near and long term applications, (2) has the greatest chance for completion without further government funding, (3) will further define technical and economic feasibility of a 66 MWe gross size plant that is adequate to meet the requirements for utility and industrial process heat applications, (4) can potentially be constructed and operated within the next five years, and (5) incorporates solar central receiver technology and represents state-of-the-art development. This volume on the preliminary design includes the following sections: executive summary; introduction; changes from advanced conceptual design; preliminary design; system characteristics; economic analysis; and development plan.

  16. Loop Gain and Circuit Parameters for Residual Carrier Tracking in the Advanced DSN Block V Receiver

    NASA Technical Reports Server (NTRS)

    Young, P. H.

    1984-01-01

    A circuit level analysis for residual carrier tracking of a deep space network signal by a proposed Block V receiver as conceived by the Receiver Advanced Development Team is presented. The objective is to aid the circuit designer in selection of loop parameters to achieve the required performance objectives. The topics specifically addressed are: (1) loop stability and gain requirements, (2) loop component parametric equations, and (3) phase detector technology.

  17. Design of a redirector/reconcentrator for use at the Central Receiver Test Facility

    SciTech Connect

    Ghanbari, C.M.; Mulholland, G.P.; Otts, J.V.

    1988-03-01

    The Central Receiver Test Facility (CRTF), operated for the Department of Energy by Sandia National Laboratories in Albuquerque, New Mexico, was constructed for the purpose of evaluating solar central receiver design concepts. The facility consists of an array of 222 hilostats in a north-field configuration that reflects and ficuses the sun's energy toward a towaer 60 m high. Throughout the history of the CRTF, there has been an interest in beam redirectors or reconcentrators. The objective for this paper is to discuss the numerous code modifications required for the facility code HELIOS to be able to model the redirector-radome configuration. Note that this particular geometry was one that we had been asked to irradiate with energy from a redirector;however, the general model is applicable to any geometry. The model simulates the solar flux-density pattern from reflecting concentrators and follows the incident solar radiation through the atmosphere, the collection system, and finally onto the target. The model includes most pertinent factors that influence the optical performance of a collector system. Although the standard uotput contains information concerning sun shape distributions the atmospheric attenuation, probably the most useful output is the flux-density pattern at a grid of points on a receiver surface and the integral of this distribution over the surface to obtain power. 3 refs., 5 figs., 2 tabs.

  18. 76 FR 67229 - Governors' Designees Receiving Advance Notification of Transportation of Certain Shipments of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-31

    ... Nuclear Waste and Spent Fuel On January 6, 1982 (47 FR 596 and 47 FR 600), the U.S. Nuclear Regulatory... or their designees by NRC licensees prior to transportation of certain shipments of nuclear waste and... Receive Advance Notification of Nuclear Waste Shipments State Part 71 Part 73 ALABAMA Colonel Hugh...

  19. 77 FR 38859 - Governors' Designees Receiving Advance Notification of Transportation of Certain Shipments of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... Nuclear Waste and Spent Fuel On January 6, 1982 (47 FR 596 and 47 FR 600), the U.S. Nuclear Regulatory... or their designees by NRC licensees prior to transportation of certain shipments of nuclear waste and... Environmental Management Programs. Individuals to Receive Advance Notification of Nuclear Waste Shipments...

  20. 41 CFR 301-51.200 - For what expenses may I receive a travel advance?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... personal check, or travelers check) Any time you are on official travel. (1) M&IE covered by the per diem... receive a travel advance? 301-51.200 Section 301-51.200 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES,...

  1. 41 CFR 301-51.200 - For what expenses may I receive a travel advance?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... personal check, or travelers check) Any time you are on official travel. (1) M&IE covered by the per diem... receive a travel advance? 301-51.200 Section 301-51.200 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES,...

  2. 41 CFR 301-51.200 - For what expenses may I receive a travel advance?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... personal check, or travelers check) Any time you are on official travel. (1) M&IE covered by the per diem... receive a travel advance? 301-51.200 Section 301-51.200 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES,...

  3. 41 CFR 301-51.200 - For what expenses may I receive a travel advance?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... personal check, or travelers check) Any time you are on official travel. (1) M&IE covered by the per diem... receive a travel advance? 301-51.200 Section 301-51.200 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES,...

  4. 25 CFR 170.615 - Can a tribe receive advance payments for non-construction activities?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Can a tribe receive advance payments for non-construction activities? 170.615 Section 170.615 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Service Delivery for Indian Reservation Roads Contracts...

  5. 25 CFR 170.615 - Can a tribe receive advance payments for non-construction activities?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Can a tribe receive advance payments for non-construction activities? 170.615 Section 170.615 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Service Delivery for Indian Reservation Roads Contracts...

  6. 25 CFR 170.615 - Can a tribe receive advance payments for non-construction activities?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Can a tribe receive advance payments for non-construction activities? 170.615 Section 170.615 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN RESERVATION ROADS PROGRAM Service Delivery for Indian Reservation Roads Contracts...

  7. 41 CFR 301-51.200 - For what expenses may I receive a travel advance?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... personal check, or travelers check) Any time you are on official travel. (1) M&IE covered by the per diem... receive a travel advance? 301-51.200 Section 301-51.200 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES ARRANGING FOR TRAVEL SERVICES,...

  8. Financing alternatives and incentives for solar-thermal central-receiver systems

    SciTech Connect

    Bos, P.B.

    1982-07-01

    As a result of various recently enacted incentive and regulatory legislation combined with the new administration policy and budgetary guidelines, the commercialization of solar thermal central receiver systems will involve financing alternatives other than conventional utility financing. This study was conducted to identify these potential financing alternatives and the associated requirements and impacts on the Department of Energy program. Based upon this analysis, it is concluded that the current alternative financing window is extremely short (through 1985), and that an extension or at the least a gradual phasing out, of the solar tax credits is necessary for the successful transfer of the central receiver technology to the private sector. Furthermore, throughout this time period, continued government support of the R and D activities is necessary to provide the necessary confidence in this technology for the private (financial) sector to underwrite this technology transfer. Consequently, even though the central receiver technology shows high promise for replacing a significant fraction of the oil/gas-fired utility industry peaking and intermediate generation, the current readiness status of this technology still requires further direct and indirect government support for a successful technology transfer. The direct government research and development support will provide the basis for a technological readiness and confidence, whereas the indirect tax incentive support serves to underwrite the extraordinary risks associated with the technology transfer. These support requirements need only be limited to and decreasing during this technology transfer phase, since as the systems approach successful full-scale commercialization, the extraordinary risks will be gradually eliminated. At the time of commercialization the system's value should be on a par with the installed system's cost.

  9. Preliminary design of the Carrisa Plains solar central receiver power plant. Volume I. Executive summary

    SciTech Connect

    Not Available

    1983-12-31

    The design of the 30 MWe central receiver solar power plant to be located at Carrisa Plains, San Luis Obispo County, California, is summarized. The plant uses a vertical flat-panel (billboard) solar receiver located at the top of a tower to collect solar energy redirected by approximately 1900 heliostats located to the north of the tower. The solar energy is used to heat liquid sodium pumped from ground level from 610 to 1050/sup 0/F. The power conversion system is a non-reheat system, cost-effective at this size level, and designed for high-efficiency performance in an application requiring daily startup. Successful completion of this project will lead to power generation starting in 1986. This report also discusses plant performance, operations and maintenance, development, and facility cost estimate and economic analysis.

  10. Line-focus solar central power system, phase I. Subsystem experiment: receiver heat transfer

    SciTech Connect

    Slemmons, A J

    1980-04-01

    Wind-tunnel tests confirmed that heat losses due to natural convection are negligible in the line-focus, solar-powered receiver. Anomalies in the forced-convection tests prevented definitive conclusions regarding the more important forced convection. Flow-visualization tests using a water table show much lower velocities inside the receiver cavity than outside, supporting the supposition that the forced-heat transfer should be less than that from a standard exposed cylinder. Furthermore, the water-table tests showed ways to decrease the low velocities in the cavity should this be desired. Further wind-tunnel testing should be done to confirm estimates and to support advanced design. This testing can be done in standard wind tunnels since only the forced convection is of concern.

  11. Constraining the Lithospheric Structure of the Central Andes Using P- and S- wave Receiver Functions

    NASA Astrophysics Data System (ADS)

    Ryan, J. C.; Beck, S. L.; Zandt, G.; Wagner, L. S.; Minaya, E.; Tavera, H.

    2014-12-01

    The Central Andean Plateau (CAP) has elevations in excess of 3 km, and is part of the Andean Cordillera that resulted in part from shortening along the western edge of South America as it was compressed between the subducting Nazca plate and underthrusting Brazilian cratonic lithosphere. We calculated P- and S-wave receiver functions for the Central Andean Uplift and Geodynamics of High Topography (CAUGHT) temporary deployment of broadband seismometers in the Bolivian orocline (12°-20°S) region to investigate crustal thickness and lithospheric structure. Migration of the receiver functions is done using common conversion point (CCP) stacks through a 3D shear velocity model from ambient noise tomography (Ward et al., 2013). The P- and S-wave receiver functions provide similar estimates of the depth to Moho under the CAP. Crustal thicknesses include 60-65 km thick crust underneath the Bolivian Altiplano, crust that varies from ~70 km to ~50 km underneath the Eastern Cordillera and Interandean zone, and thins to 50 to 40 km crust in the Subandes and the edge of the foreland. The variable crustal thickness of the Eastern Cordillera and Interandean zone ranges from >70 km associated with the Los Frailes volcanic field at 19°-20°S to ~55 km beneath the 6 km peaks of the Cordillera Real at ~16°S. From our S-wave receiver functions, that have no multiples that can interfere with deeper structure, we also identify structures below the Moho. Along a SW-NE line that runs near La Paz where we have our highest station density, the S-wave CCP receiver-function stacks show a strong negative polarity arrival at a depth of ~120 km from the eastern edge of the Altiplano to the Subandean zone. We suggest this may be a good candidate for the base of the CAP lithosphere. In addition, above this depth the mantle is strongly layered, suggesting that there is not a simple high velocity mantle lithosphere associated with the continental lithosphere underthrusting the Andean orogen

  12. Advances in the treatment of central serous chorioretinopathy

    PubMed Central

    Abouammoh, Marwan A.

    2015-01-01

    Central serous chorioretinopathy is a disease that is partly understood. Novel advancements have led to further understanding of the disease, and have identified choroidal dysfunction as the principal element in CSCR development. New imaging tools have aided in better monitoring disease response to various treatment models. Enhanced depth imaging optical coherence tomography, in particular, has helped in observing choroidal thickness changes after various treatment models. To date, photodynamic therapy and focal laser remain the main stay of treatment. More understanding of disease pathophysiology in the future will help in determining the drug of choice and the best management option for such cases. PMID:26586979

  13. Improved high temperature solar absorbers for use in Concentrating Solar Power central receiver applications.

    SciTech Connect

    Stechel, Ellen Beth; Ambrosini, Andrea; Hall, Aaron Christopher; Lambert, Timothy L.; Staiger, Chad Lynn; Bencomo, Marlene

    2010-09-01

    Concentrating solar power (CSP) systems use solar absorbers to convert the heat from sunlight to electric power. Increased operating temperatures are necessary to lower the cost of solar-generated electricity by improving efficiencies and reducing thermal energy storage costs. Durable new materials are needed to cope with operating temperatures >600 C. The current coating technology (Pyromark High Temperature paint) has a solar absorptance in excess of 0.95 but a thermal emittance greater than 0.8, which results in large thermal losses at high temperatures. In addition, because solar receivers operate in air, these coatings have long term stability issues that add to the operating costs of CSP facilities. Ideal absorbers must have high solar absorptance (>0.95) and low thermal emittance (<0.05) in the IR region, be stable in air, and be low-cost and readily manufacturable. We propose to utilize solution-based synthesis techniques to prepare intrinsic absorbers for use in central receiver applications.

  14. Power and Efficiency Analysis of a Solar Central Receiver Combined Cycle Plant with a Small Particle Heat Exchanger Receiver

    NASA Astrophysics Data System (ADS)

    Virgen, Matthew Miguel

    Two significant goals in solar plant operation are lower cost and higher efficiencies. To achieve those goals, a combined cycle gas turbine (CCGT) system, which uses the hot gas turbine exhaust to produce superheated steam for a bottoming Rankine cycle by way of a heat recovery steam generator (HRSG), is investigated in this work. Building off of a previous gas turbine model created at the Combustion and Solar Energy Laboratory at SDSU, here are added the HRSG and steam turbine model, which had to handle significant change in the mass flow and temperature of air exiting the gas turbine due to varying solar input. A wide range of cases were run to explore options for maximizing both power and efficiency from the proposed CSP CCGT plant. Variable guide vanes (VGVs) were found in the earlier model to be an effective tool in providing operational flexibility to address the variable nature of solar input. Combined cycle efficiencies in the range of 50% were found to result from this plant configuration. However, a combustor inlet temperature (CIT) limit leads to two distinct Modes of operation, with a sharp drop in both plant efficiency and power occurring when the air flow through the receiver exceeded the CIT limit. This drawback can be partially addressed through strategic use of the VGVs. Since system response is fully established for the relevant range of solar input and variable guide vane angles, the System Advisor Model (SAM) from NREL can be used to find what the actual expected solar input would be over the course of the day, and plan accordingly. While the SAM software is not yet equipped to model a Brayton cycle cavity receiver, appropriate approximations were made in order to produce a suitable heliostat field to fit this system. Since the SPHER uses carbon nano-particles as the solar absorbers, questions of particle longevity and how the particles might affect the flame behavior in the combustor were addressed using the chemical kinetics software Chemkin

  15. Changes in the mantle transition zone from central Europe to the East European Craton as seen by receiver functions

    NASA Astrophysics Data System (ADS)

    Knapmeyer-Endrun, B.; Krüger, F.; Passeq Working Group

    2012-04-01

    The depth to which lithospheric roots of cratons influence the surrounding mantle has important consequences for our understanding of the thermal structure of the mantle and its geodynamics. Still, this information is often not well constrained: previous studies of depth variations in mantle transition zone (MTZ) discontinuities beneath cratons led to variable results, depending on the craton under investigation. Here, we present evidence that the influence of the East European Craton extends into the MTZ. We study teleseismic P-receiver functions recorded at more than 400 stations across central and eastern Europe, from the Netherlands to Estonia. Using P-to-S converted waves, receiver functions yield relative travel times to the 410 km and 660 km discontinuities and are especially useful in mapping variations in MTZ thickness. The main data source in our study is the multinational PASSEQ experiment, which achieved the densest coverage with seismic stations yet in Poland and Lithuania by using about 200 temporary stations installed from 2006 to 2008. These recordings are supplemented by national and regional networks and broad-band data from older temporary deployments. The large data set allows us to image the MTZ across the Trans-European Suture Zone (TESZ), the western boundary of the East European Craton, in high resolution. We observe significantly advanced onset times, by as much as 2 s compared to standard Earth models and up to 3 s compared to the Central European Platform, for conversions from both MTZ discontinuities for locations within the craton. This effect is expected and due to the higher velocities in the mantle above the MTZ, e.g. the cratonic root. It gets even more pronounced when the opposing effect of variable crustal thickness (50 km and more within the craton in contrast to 30 to 35 km in central Europe) is considered. Additionally, the differential travel time between the two discontinuities is increased by 1 s beneath the craton, most

  16. Solar Central Receiver Hybrid Power Systems sodium-cooled receiver concept. Final report. Volume II, Book 2. Conceptual design, Sections 5 and 6

    SciTech Connect

    1980-01-01

    The overall, long-term objective of the Solar Central Receiver Hybrid Power System program is to identify, characterize, and ultimately demonstrate the viability and cost effectiveness of solar/fossil, steam Rankine cycle, hybrid power systems that: (1) consist of a combined solar central receiver energy source and a nonsolar energy source at a single, common site, (2) may operate in the base, intermediate, and peaking capacity modes, (3) produce the rated output independent of variations in solar insolation, (4) provide a significant savings (50% or more) in fuel consumption, and (5) produce power at the minimum possible cost in mills/kWh. It is essential that these hybrid concepts be technically feasible and economically competitive with other systems in the near to mid-term time period (1985-1990) on a commercial scale. The program objective for Phase I is to identify and conceptually characterize solar/fossil steam Rankine cycle, commercial-scale, power plant systems that are economically viable and technically feasible. This volume contains the detailed conceptual design and cost/performance estimates and an assessment of the commercial scale solar central receiver hybrid power system. (WHK)

  17. Seismological Features of the Subducting Slab Beneath the Kii Peninsula, Central Japan, Revealed by Receiver Functions

    NASA Astrophysics Data System (ADS)

    Shiomi, K.; Park, J.

    2007-12-01

    We report seismological evidence that the subducting Philippine Sea slab (PHS) beneath the Kii Peninsula, central Japan, can be divided into three segments. Offshore the Kii Peninsula, the "Tonankai" and "Nankai" fault segments suffer mega-thrust earthquakes that repeat every 100 to 150 years. The structure of the young, thin, contorted PHS is important to the seismo-tectonics in this region. We apply the receiver function (RF) analysis to 26 Hi-net short-period and 4 F-net broad-band seismographic stations. In the case that dipping velocity discontinuities and/or anisotropic media exist beneath seismometer, both radial RFs and transverse RFs contain useful information to estimate underground structure. For isotropic media with a dipping-slab interface, back- azimuthal variation in RFs depends largely on three parameters, the downdip azimuth, dip angle and the depth of the interface. We stack both radial and transverse RFs with allowance a time-shift caused by the dipping interface, searching for optimal parameters based on the grid-search technique at each station. At some stations located near the eastern coastline of the Kii Peninsula, the dip angle of the interface inferred from RF stacking is much steeper than that estimated by the local seismicity. This discrepancy arises from the interference of two slab-converted phases, suggesting a layer atop the slab. In these cases we refine the stack to distinguish two slab phases and estimate three parameters of each dipping interface separately. Two interfaces with the same dip direction and low dip angle are estimated at these stations, with depth difference near 6 km. Thus, the shallower interface may be related to the layer within the oceanic crust and the deeper one is the slab Moho. These double-layered interfaces are detected only at stations located up-dip of a belt-like distribution of non- volcanic low-frequency tremor. Comparing the interface dips estimated in this study with the direction of slab motion

  18. Dendrimer Advances for the Central Nervous System Delivery of Therapeutics

    PubMed Central

    2013-01-01

    The effectiveness of noninvasive treatment for central nervous system (CNS) diseases is generally limited by the poor access of therapeutic agents into the CNS. Most CNS drugs cannot permeate into the brain parenchyma because of the blood-brain barrier (BBB), and overcoming this has become one of the most significant challenges in the development of CNS therapeutics. Rapid advances in nanotechnology have provided promising solutions to this challenge. This review discusses the latest applications of dendrimers in the treatment of CNS diseases with an emphasis on brain tumors. Dendrimer-mediated drug delivery, imaging, and diagnosis are also reviewed. The toxicity, biodistribution, and transport mechanisms in dendrimer-mediated delivery of CNS therapeutic agents bypassing or crossing the BBB are also discussed. Future directions and major challenges of dendrimer-mediated delivery of CNS therapeutic agents are included. PMID:24274162

  19. The Meaning of Parenteral Hydration to Family Caregivers and Patients with Advanced Cancer Receiving Hospice Care

    PubMed Central

    Cohen, Marlene Z; Torres-Vigil, Isabel; Burbach, Beth E.; de Rosa, Allison; Bruera, Eduardo

    2012-01-01

    Context In the U.S., patients with advanced cancer who are dehydrated or have decreased oral intake virtually always receive parenteral hydration in acute care facilities but rarely in the hospice setting. Objectives To describe the meaning of hydration for terminally ill cancer patients in home hospice care and for their primary caregivers. Methods Phenomenological interviews were conducted at two time points with 85 patients and 84 caregivers enrolled in a randomized, double-blind, controlled trial examining the efficacy of parenteral hydration in patients with advanced cancer receiving hospice care in the southern U.S. Transcripts were analyzed hermeneutically by the interdisciplinary research team until consensus on the theme labels was reached. Results Patients and their family caregivers both saw hydration as meaning hope and comfort. Hope was the view that hydration might prolong a life of dignity and enhance quality of life by reducing symptoms such as fatigue and increasing patients’ alertness. Patients and caregivers also described hydration as improving patients’ comfort by reducing pain, enhancing the effectiveness of pain medication, and nourishing the body, mind and spirit. Conclusion These findings differ from traditional hospice beliefs that dehydration enhances patient comfort given that patients and their families in the study viewed fluids as enhancing comfort, dignity and quality of life. Discussion with patients and families about their preferences for hydration may help tailor care plans to meet specific patient needs. PMID:22459230

  20. The design of future central receiver power plants based on lessons learned from the Solar One Pilot Plant

    NASA Astrophysics Data System (ADS)

    Kolb, G. J.

    The 10-MW(sub e) Solar One Pilot Plant was the world's largest solar central receiver power plant. During its power production years it delivered over 37,000 MWhrs (net) to the utility grid. In this type of electric power generating plant, large sun-tracking mirrors called heliostats reflect and concentrate sunlight onto a receiver mounted on top of a tower. The receiver transforms the solar energy into thermal energy that heats water, turning it into superheated steam that drives a turbine to generate electricity. The Solar One Pilot Plant successfully demonstrated the feasibility of generating electricity with a solar central receiver power plant. During the initial 2 years the plant was tested and 4 years the plant was operated as a power plant, a great deal of data was collected relating to the efficiency and reliability of the plant's various systems. This paper summarizes these statistics and compares them to goals developed by the U.S. Department of Energy. Based on this comparison, improvements in the design and operation of future central receiver plants are recommended. Research at Sandia National Laboratories and the U.S. utility industry suggests that the next generation of central receiver power plants will use a molten salt heat transfer fluid rather than water/steam. Sandia has recently completed the development of the hardware needed in a molten salt power plant. Use of this new technology is expected to solve many of the performance problems encountered at Solar One. Projections for the energy costs from these future central receiver plants are also presented. For reference, these projections are compared to the current energy costs from the SEGS parabolic trough plants now operating in Southern California.

  1. Transient analysis of a molten salt central receiver (MSCR) in a solar power plant

    NASA Astrophysics Data System (ADS)

    Joshi, A.; Wang, C.; Akinjiola, O.; Lou, X.; Neuschaefer, C.; Quinn, J.

    2016-05-01

    Alstom is developing solar power tower plants utilizing molten salt as the working fluid. In solar power tower, the molten salt central receiver (MSCR) atop of the tower is constructed of banks of tubes arranged in panels creating a heat transfer surface exposed to the solar irradiation from the heliostat field. The molten salt heat transfer fluid (HTF), in this case 60/40%wt NaNO3-KNO3, flows in serpentine flow through the surface collecting sensible heat thus raising the HTF temperature from 290°C to 565°C. The hot molten salt is stored and dispatched to produce superheated steam in a steam generator, which in turn produces electricity in the steam turbine generator. The MSCR based power plant with a thermal energy storage system (TESS) is a fully dispatchable renewable power plant with a number of opportunities for operational and economic optimization. This paper presents operation and controls challenges to the MSCR and the overall power plant, and the use of dynamic model computer simulation based transient analyses applied to molten salt based solar thermal power plant. This study presents the evaluation of the current MSCR design, using a dynamic model, with emphasis on severe events affecting critical process response, such as MS temperature deviations, and recommend MSCR control design improvements based on the results. Cloud events are the scope of the transient analysis presented in this paper. The paper presents results from a comparative study to examine impacts or effects on key process variables related to controls and operation of the MSCR plant.

  2. Preliminary design of a solar central receiver for a site-specific repowering application (Saguaro Power Plant). Volume 1. Executive summary. Final report, October 1982-September 1983

    SciTech Connect

    Weber, E.R.

    1983-09-01

    The preliminary design of a solar central receiver repowered gas/oil fired steam-Rankine cycle electric power generation plant was completed. The design is based on a central receiver technology using molten salt (60% NaNO/sub 3/, 40% KNO/sub 3/, by weight) for the heat transport and thermal storage fluid. Unit One of APS's Saguaro power plant located 43 km (27 mi) northwest of Tucson, AZ, is to be repowered. The selection of both the site and the molten salt central receiver promotes a near-term feasibility demonstration and cost-effective power production from an advanced solar thermal technology. The recommended system concept is to repower the existing electric power generating system at the minimum useful level (66 MW/sub e/ gross) using a field of 4850 Martin Marietta second-generation (58.5 m/sup 2/) heliostats and a storage capacity of 4.0 hours. The storage capacity will be used to optimize dispatch of power to the utility system. The preliminary design was based on the use of the systems approach to design where the overall project was divided into systems, each of which is clearly bounded, and performs specific functions. The total project construction cost was estimated to be 213 million in 1983 dollars. The plant will be capable of displacing fossil energy equivalent to 2.4 million barrels of No. 6 oil in its first 10 years of operation.

  3. Evaluation of the variability of wind speed at different heights and its impact on the receiver efficiency of central receiver systems

    NASA Astrophysics Data System (ADS)

    Delgado, A.; Gertig, C.; Blesa, E.; Loza, A.; Hidalgo, C.; Ron, R.

    2016-05-01

    Typical plant configurations for Central Receiver Systems (CRS) are comprised of a large field of heliostats which concentrate solar irradiation onto the receiver, which is elevated hundreds of meters above the ground. Wind speed changes with altitude above ground, impacting on the receiver thermal efficiency due to variations of the convective heat losses. In addition, the physical properties of air vary at high altitudes to a significant degree, which should be considered in the thermal losses calculation. DNV GL has long-reaching experience in wind energy assessment with reliable methodologies to reduce the uncertainty of the determination of the wind regime. As a part of this study, DNV GL estimates the wind speed at high altitude for different sites using two methods, a detailed estimation applying the best practices used in the wind energy sector based on measurements from various wind sensors and a simplified estimation applying the power law (1, 2) using only one wind measurement and a representative value for the surface roughness. As a result of the study, a comparison of the wind speed estimation considering both methods is presented and the impact on the receiver performance for the evaluated case is estimated.

  4. Mechanisms Underpinning Increased Plasma Creatinine Levels in Patients Receiving Vemurafenib for Advanced Melanoma

    PubMed Central

    Hurabielle, Charlotte; Pillebout, Evangéline; Stehlé, Thomas; Pagès, Cécile; Roux, Jennifer; Schneider, Pierre; Chevret, Sylvie; Chaffaut, Cendrine; Boutten, Anne; Mourah, Samia; Basset-Seguin, Nicole; Vidal-Petiot, Emmanuelle; Lebbé, Céleste; Flamant, Martin

    2016-01-01

    Context Serum creatinine has been reported to increase in patients receiving Vemurafenib, yet neither the prevalence nor the mechanism of this adverse event are known. Objective We aimed to evaluate the frequency and the mechanisms of increases in plasma creatinine level in patients receiving Vemurafenib for advanced melanoma. Methods We performed a retrospective monocentric study including consecutive patients treated with Vemurafenib for an advanced melanoma. We collected clinical and biological data concerning renal function before introduction of Vemurafenib and in the course of monthly follow-up visits from March 2013 to December 2014. Cystatin C-derived glomerular filtration rate was evaluated before and after Vemurafenib initiation, as increase in serum cystatin C is specific to a decrease in the glomerular filtration rate. We also performed thorough renal explorations in 3 patients, with measurement of tubular secretion of creatinine before and after Vemurafenib initiation and a renal biopsy in 2 patients. Results 70 patients were included: 97% of them displayed an immediate, and thereafter stable, increase in creatinine (+22.8%) after Vemurafenib initiation. In 44/52 patients in whom Vemurafenib was discontinued, creatinine levels returned to baseline. Serum cystatin C increased, although proportionally less than serum creatinine, showing that creatinine increase under vemurafenib was indeed partly due to a renal function impairment. In addition, renal explorations demonstrated that Vemurafenib induced an inhibition of creatinine tubular secretion. Conclusion Thus, Vemurafenib induces a dual mechanism of increase in plasma creatinine with both an inhibition of creatinine tubular secretion and slight renal function impairment. However, this side effect is mostly reversible when Vemurafenib is discontinued, and should not lead physicians to discontinue the treatment if it is effective. PMID:26930506

  5. 41 CFR 302-8.4 - May I receive an advance of funds for storage allowances covered by this part?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false May I receive an advance of funds for storage allowances covered by this part? 302-8.4 Section 302-8.4 Public Contracts and... PROPERTY 8-ALLOWANCES FOR EXTENDED STORAGE OF HOUSEHOLD GOODS (HHG) General § 302-8.4 May I receive...

  6. 41 CFR 302-8.4 - May I receive an advance of funds for storage allowances covered by this part?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false May I receive an advance of funds for storage allowances covered by this part? 302-8.4 Section 302-8.4 Public Contracts and... PROPERTY 8-ALLOWANCES FOR EXTENDED STORAGE OF HOUSEHOLD GOODS (HHG) General § 302-8.4 May I receive...

  7. 41 CFR 301-31.14 - May I receive a travel advance for transportation and/or subsistence expenses?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false May I receive a travel advance for transportation and/or subsistence expenses? 301-31.14 Section 301-31.14 Public Contracts and... TRAVEL EXPENSES 31-THREATENED LAW ENFORCEMENT/INVESTIGATIVE EMPLOYEES § 301-31.14 May I receive a...

  8. Solar Central Receiver Hybrid Power Systems sodium-cooled receiver concept. Final report. Volume II, Book 1. Conceptual design, Sections 1 through 4

    SciTech Connect

    1980-01-01

    The overall, long-term objective of the Solar Central Receiver Hybrid Power System program is to identify, characterize, and ultimately demonstrate the viability and cost effectiveness of solar/fossil, steam Rankine cycle, hybrid power systems that: (1) consist of a combined solar central receiver energy source and a nonsolar energy source at a single, common site, (2) may operate in the base, intermediate, and peaking capacity modes, (3) produce the rated output independent of variations in solar insolation, (4) provide a significant savings (50% or more) in fuel consumption, and (5) produce power at the minimum possible cost in mills/kWh. It is essential that these hybrid concepts be technically feasible and economically competitive with other systems in the near to mid-term time period (1985-1990) on a commercial scale. The program objective for Phase I is to identify and conceptually characterize solar/fossil steam Rankine cycle, commercial-scale, power plant systems that are economically viable and technically feasible. This volume presents in detail the market analysis, parametric analysis, and the selection process for the preferred system. (WHK)

  9. Converted Ps amplitude variations on a dipping interface: Application to receiver functions in central Japan

    NASA Astrophysics Data System (ADS)

    Shiomi, K.; Park, J. J.

    2009-12-01

    Using the delay times of Ps converted phases in receiver functions (RFs), one can estimate the depth of interfaces underneath a seismic station. One can also evaluate elastic properties at an interface from changes of Ps polarity and Ps amplitude. Ps amplitude depends primarily on the impedance contrast at an interface, but the variation of Ps amplitude on back azimuth φ and ray parameter of the incoming P wave is affected if the interface is dipping and/or anisotropic rock surrounds the interface. In this study, we estimate RFs with various back azimuths and define a 'standard amplitude' of a converted phase at a dipping interface beneath a station, based on back-azimuth dependence of the Ps amplitudes. We apply this analysis to the stations located within the Kii Peninsula, central Japan. First, we estimate the plunge azimuth of the dipping oceanic Moho beneath a station from the delay-time moveout of the Moho-converted Ps phase using the method by Park et al. (2007; AGU FM). Using the theoretical Ps arrival time evaluated from this information, we read the amplitude of RFs. Since this amplitude data shows strong scatter, we calculate an average and its standard deviation for each 5°bin, and fit a simple function constructed with sin(φ), sin(2φ) and constant harmonic terms with a least-squares algorithm. The component of sin(φ) corresponds mainly to the contribution from the dipping interface, and that of sin(2φ) indicates the strength of anisotropy near the velocity interface. At almost all stations, the sin(φ) component dominates, but 4-lobed back-azimuth dependence is clearly confirmed at several stations in the southern part of the peninsula, where strongly anisotropic rocks have been proposed by other researchers. We found that the standard amplitudes and bias components depend on oceanic-Moho depth. As the oceanic Moho deepens to ~40 km, the Ps amplitudes decrease from 13% to 6% of the primary P wave. Ps amplitudes flatten at 5-7% of the primary P

  10. Efficacy of prophylactic anti-diarrhoeal treatment in patients receiving Campto for advanced colorectal cancer.

    PubMed

    Duffour, J; Gourgou, S; Seitz, J F; Senesse, P; Boutet, O; Castera, D; Kramar, A; Ychou, M

    2002-01-01

    This study assessed the efficacy of combined prophylactic and curative anti-diarrhoeal medication in advanced colorectal patients treated by irinotecan. Thirty-four pre-treated eligible patients were evaluated. There were 44% women, the median age was 65 and 38% of the patients had a 0 performance status. The patients received sucralfate(4g/d) and nifuroxazide(600 mg/d) prophylactic treatment on days 0-7. In the case of severe diarrhoea, preventive treatment was replaced by loperamide(12 mg/d) and diosmectite (9 g/d). Grade 3 delayed diarrhoea occurred in 18% of patients (90% CI: [9.5-28.9]) and 4.6% of cycles. No grade 4 delayed diarrhoea was observed. Twenty-nine patients (85%) received the preventive treatment at cycle 1, while 14% (90% CI: [6.2-25.7]) experienced grade 3 delayed diarrhoea in 3.7% of cycles for a median 4.5 days. The objective response rate was 8% (90% CI [1.4-23.1]) among the 25 assessable patients. Preventive combined treatment is effective in reducing the incidence of severe delayed diarrhoea, and it should be proposed to patients treated with mono-therapy Campto(r) and evaluated in poly-chemotherapy protocols. PMID:12552984

  11. Household Air Pollution Exposures of Pregnant Women Receiving Advanced Combustion Cookstoves in India: Implications for Intervention

    PubMed Central

    Balakrishnan, Kalpana; Sambandam, Sankar; Ghosh, Santu; Mukhopadhyay, Krishnendu; Vaswani, Mayur; Arora, Narendra K.; Jack, Darby; Pillariseti, Ajay; Bates, Michael N.; Smith, Kirk R.

    2016-01-01

    BACKGROUND Household air pollution (HAP) resulting from the use of solid cooking fuels is a leading contributor to the burden of disease in India. Advanced combustion cookstoves that reduce emissions from biomass fuels have been considered potential interventions to reduce this burden. Relatively little effort has been directed, however, to assessing the concentration and exposure changes associated with the introduction of such devices in households. OBJECTIVES The aim of this study was to describe HAP exposure patterns in pregnant women receiving a forced-draft advanced combustion cookstove (Philips model HD 4012) in the SOMAARTH Demographic Development & Environmental Surveillance Site (DDESS) Palwal District, Haryana, India. The monitoring was performed as part of a feasibility study to inform a potential large-scale HAP intervention (Newborn Stove trial) directed at pregnant women and newborns. METHODS This was a paired comparison exercise study with measurements of 24-hour personal exposures and kitchen area concentrations of carbon monoxide (CO) and particulate matter less than 2.5 μm in aerodynamic diameter (PM2.5), before and after the cookstove intervention. Women (N = 65) were recruited from 4 villages of SOMAARTH DDESS. Measurements were performed between December 2011 and March 2013. Ambient measurements of PM2.5 were also performed throughout the study period. FINDINGS Measurements showed modest improvements in 24-hour average concentrations and exposures for PM2.5 and CO (ranging from 16% to 57%) with the use of the new stoves. Only those for CO showed statistically significant reductions. CONCLUSION Results from the present study did not support the widespread use of this type of stove in this population as a means to reliably provide health-relevant reductions in HAP exposures for pregnant women compared with open biomass cookstoves. The feasibility assessment identified multiple factors related to user requirements and scale of adoption within

  12. Effects of vertically ribbed surface roughness on the forced convective heat losses in central receiver systems

    NASA Astrophysics Data System (ADS)

    Uhlig, Ralf; Frantz, Cathy; Fritsch, Andreas

    2016-05-01

    External receiver configurations are directly exposed to ambient wind. Therefore, a precise determination of the convective losses is a key factor in the prediction and evaluation of the efficiency of the solar absorbers. Based on several studies, the forced convective losses of external receivers are modeled using correlations for a roughened cylinder in a cross-flow of air. However at high wind velocities, the thermal efficiency measured during the Solar Two experiment was considerably lower than the efficiency predicted by these correlations. A detailed review of the available literature on the convective losses of external receivers has been made. Three CFD models of different level of detail have been developed to analyze the influence of the actual shape of the receiver and tower configuration, of the receiver shape and of the absorber panels on the forced convective heat transfer coefficients. The heat transfer coefficients deduced from the correlations have been compared to the results of the CFD simulations. In a final step the influence of both modeling approaches on the thermal efficiency of an external tubular receiver has been studied in a thermal FE model of the Solar Two receiver.

  13. Management of peripherally inserted central catheters (PICC) in pediatric heart failure patients receiving continuous inotropic support.

    PubMed

    Giangregorio, Maeve; Mott, Sandra; Tong, Elizabeth; Handa, Sonia; Gauvreau, Kimberlee; Connor, Jean Anne

    2014-01-01

    The study aim was to evaluate present practice of maintaining PICC line patency in pediatric heart failure patients receiving continuous inotropes by comparing one cohort receiving low dose continuous heparin with one receiving no heparin. A case control retrospective chart review compared the two cohorts on duration of patency (measured in days) and need for thrombolytic agents. Median duration of patency for the heparin group was 24 days versus 16 days for the no heparin group (p=0.07). Use of thrombolytic agents was 28% in the heparin group compared to 50% in the no heparin group (p=0.08). Although not statistically significant, findings were clinically significant and supportive of current practice.

  14. High-temperature thermal storage systems for advanced solar receivers materials selections

    NASA Technical Reports Server (NTRS)

    Wilson, D. F.; Devan, J. H.; Howell, M.

    1990-01-01

    Advanced space power systems that use solar energy and Brayton or Stirling heat engines require thermal energy storage (TES) systems to operate continuously through periods of shade. The receiver storage units, key elements in both Brayton and Stirling systems, are designed to use the latent heat of fusion of phase-change materials (PCMs). The power systems under current consideration for near-future National Aeronautics and Space Administration space missions require working fluid temperatures in the 1100 to 1400 K range. The PCMs under current investigation that gave liquid temperatures within this range are the fluoride family of salts. However, these salts have low thermal conductivity, which causes large temperature gradients in the storage systems. Improvements can be obtained, however, with the use of thermal conductivity enhancements or metallic PCMs. In fact, if suitable containment materials can be found, the use of metallic PCMs would virtually eliminate the orbit associated temperature variations in TES systems. The high thermal conductivity and generally low volume change on melting of germanium and alloys based on silicon make them attractive for storage of thermal energy in space power systems. An approach to solving the containment problem, involving both chemical and physical compatibility, preparation of NiSi/NiSi2, and initial results for containment of germanium and NiSi/NiSi2, are presented.

  15. Final report on the power production phase of the 10 MW/sub e/ Solar Thermal Central Receiver Pilot Plant

    SciTech Connect

    Radosevich, L.G.

    1988-03-01

    This report describes the evaluations of the power production testing of Solar One, the 10 MW/sub e/ Solar Thermal Central Receiver Pilot Plant near Barstow, California. The Pilot Plant, a cooperative project of the US Department of Energy and utility firms led by the Southern California Edison Company, began a three year period of power production operation in August 1984. During this period, plant performance indicators, such as capacity factor, system efficiency, and availability, were studied to assess the operational capability of the Pilot Plant to reliably supply electrical power. Also studied was the long-term performance of such key plant components as the heliostats and the receiver. During the three years of power production, the Pilot Plant showed an improvement in performance. Considerable increases in capacity factor, system efficiency, and availability were achieved. Heliostat operation was reliable, and only small amounts of mirror corrosion were observed. Receiver tube leaks did occur, however, and were the main cause of the plant's unscheduled outages. The Pilot Plant provided valuable lessons which will aid in the design of future solar central receiver plants. 53 refs., 46 figs., 4 tabs.

  16. A nightly conditioning method to reduce parasitic power consumption in molten-salt central-receiver solar-power plants

    SciTech Connect

    Pacheco, J.E.

    1995-06-01

    A method to reduce nightly parasitic power consumption in a molten salt central receiver is discussed where salt is drained from the piping and heat tracing is turned off to allow the piping to cool to ambient overnight, then in the morning the pipes are filled while they are cold. Since the piping and areas of the receiver in a molten-nitrate salt central-receiver solar power plant must be electrically heated to maintain their temperatures above the nitrate salt freezing point (430{degrees}F, 221{degrees}C), considerable energy could be used to maintain such temperatures during nightly shut down and bad weather. Experiments and analyses have been conducted to investigate cold filling receiver panels and piping as a way of reducing parasitic electrical power consumption and increasing the availability of the plant. The two major concerns with cold filling are: (1) how far can the molten salt penetrate cold piping before freezing closed and (2) what thermal stresses develop during the associated thermal shock. Experiments and analysis are discussed.

  17. High-temperature ceramic receivers

    SciTech Connect

    Jarvinen, P. O.

    1980-01-01

    An advanced ceramic dome cavity receiver is discussed which heats pressurized gas to temperatures above 1800/sup 0/F (1000/sup 0/C) for use in solar Brayton power systems of the dispersed receiver/dish or central receiver type. Optical, heat transfer, structural, and ceramic material design aspects of the receiver are reported and the development and experimental demonstration of a high-temperature seal between the pressurized gas and the high-temperature silicon carbide dome material is described.

  18. Bioenergy from Coastal bermudagrass receiving subsurface drip irrigation with advance-treated swine wastewater.

    PubMed

    Cantrell, Keri B; Stone, Kenneth C; Hunt, Patrick G; Ro, Kyoung S; Vanotti, Matias B; Burns, Joseph C

    2009-07-01

    Coastal bermudagrass (Cynodon dactylon L.) may be a potentially important source of bio-based energy in the southern US due to its vast acreage. It is often produced as part of a waste management plan with varying nutrient composition and energy characteristics on fields irrigated with livestock wastewater. The objective of this study was to determine the effect of subsurface drip irrigation with treated swine wastewater on both the quantity and quality of bermudagrass bioenergy. The treated wastewater was recycled from an advanced treatment system and used for irrigation of bermudagrass in two crop seasons. The experiment had nine water and drip line spacing treatments arrayed in a randomized complete block-design with four replicates. The bermudagrass was analyzed for calorific and mineral contents. Bermudagrass energy yields for 2004 and 2005 ranged from 127.4 to 251.4MJ ha(-1). Compared to irrigation with commercial nitrogen fertilizer, the least biomass energy density was associated with bermudagrass receiving treated swine wastewater. Yet, in 2004 the wastewater irrigated bermudagrass had greater hay yields leading to greater energy yield per ha. This decrease in energy density of wastewater irrigated bermudagrass was associated with increased concentrations of K, Ca, and Na. After thermal conversion, these compounds are known to remain in the ash portion thereby decreasing the energy density. Nonetheless, the loss of energy density using treated effluent via SDI may be offset by the positive influence of these three elements for their catalytic properties in downstream thermal conversion processes such as promoting a lesser char yield and greater combustible gas formation. PMID:19289275

  19. Preliminary discrete element modeling of a falling particle curtain for CSP central tower receivers

    NASA Astrophysics Data System (ADS)

    Zanino, R.; Ho, C. K.; Romano, D.; Savoldi, L.

    2016-05-01

    Current methods used to simulate the curtain thickness in a falling particle receiver lead to a poor agreement with the experiments. Here the Discrete Element Method (DEM) is proposed to address the problem, including both the top hopper and the interactions between particles in the model. Some first promising results are presented, showing an acceptable agreement between simulation and experiment for an ad-hoc set of input parameters. A sensitivity study provides a first assessment of the effects of the main input parameters of the model (boundary conditions at the release, particle Young's modulus, restitution coefficients and effective particle diameter) on the predicted curtain thickness.

  20. 41 CFR 302-7.106 - What documentation is required to receive an advance under the commuted rate method?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false What documentation is required to receive an advance under the commuted rate method? 302-7.106 Section 302-7.106 Public Contracts... STORAGE OF PROPERTY 7-TRANSPORTATION AND TEMPORARY STORAGE OF HOUSEHOLD GOODS AND PROFESSIONAL...

  1. 41 CFR 302-7.106 - What documentation is required to receive an advance under the commuted rate method?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false What documentation is required to receive an advance under the commuted rate method? 302-7.106 Section 302-7.106 Public Contracts... STORAGE OF PROPERTY 7-TRANSPORTATION AND TEMPORARY STORAGE OF HOUSEHOLD GOODS AND PROFESSIONAL...

  2. A method for designing a redirector/reconcentrator for use at the Central Receiver Test Facility (CRTF)

    SciTech Connect

    Ghanbari, C.M.; Mulholland, G.P.; Otts, J.V.

    1989-01-01

    The Central Receiver Test Facility (CRTF), operated for the Department of Energy by Sandia National Laboratories in Albuquerque, New Mexico, was constructed to evaluate design concepts for solar central receivers. The facility consists of an array of 222 heliostats in a northfield configuration that reflects and focuses the sun's energy toward a tower 60 m high. Throughout the history of the CRTF, there has been an interest in beam redirectors or reconcentrators. The objective of this paper is to discuss the numerous code modifications required for the facility code HELIOS to be able to model the redirector-radome configuration. This model simulates the solar flux-density pattern from reflecting concentrators and follows the incident solar radiation through the atmosphere, the collection system, and finally onto the target. The model includes most pertinent factors that influence the optical performance of a collector system. Although the standard output contains information concerning sun shape distributions and atmospheric attenuation, probably the most useful output is the flux-density pattern at a grid of points on a receiver surface and the integral of this distribution over the surface to obtain power. 3 refs., 17 figs.

  3. Nutritional rehabilitation in patients with advanced head and neck cancer receiving radiation therapy.

    PubMed

    Daly, J M; Hearne, B; Dunaj, J; LePorte, B; Vikram, B; Strong, E; Green, M; Muggio, F; Groshen, S; DeCosse, J J

    1984-10-01

    maintained mean mid-arm circumference and recovered mean serum albumin levels after radiation therapy in contrast with the orally fed group. Intensive outpatient tube-feeding nutritional support during radiation therapy in patients with advanced inoperable squamous cancer of the oropharynx significantly improved mean weight maintenance, mean caloric and protein intake, and mean serum albumin levels compared with patients who received optimal oral nutrition. Tumor response to radiation therapy, however, was unchanged.

  4. Central Receiver System (CRS) in the Small Solar Power Systems Project (SSPS) of the International Energy Agency (IEA)

    NASA Astrophysics Data System (ADS)

    Grasse, W.; Becker, M.

    1984-02-01

    Attention is given to the design features and performance of the Small Solar Power Systems Project's Central Receiver System (CRS). The heliostat field used has a total reflective surface of 3655 sq m and focuses the irradiated power on an aperture plane of 9.2 sq m atop the tower. The cavity-type receiver is rated at 2840 kW at design conditions, of which 88.3 percent is absorbed by the liquid sodium heat transfer fluid as it is heated from 275 to 530 C. The major part of the CRS's Rankine power conversion cycle is a five-stage steam motor with two preheaters. Attention is given to CRS program funding responsibilities and development milestone chronology.

  5. Evaluation of annual efficiencies of high temperature central receiver concentrated solar power plants with thermal energy storage.

    SciTech Connect

    Ehrhart, Brian David; Gill, David Dennis

    2013-07-01

    The current study has examined four cases of a central receiver concentrated solar power plant with thermal energy storage using the DELSOL and SOLERGY computer codes. The current state-of-the-art base case was compared with a theoretical high temperature case which was based on the scaling of some input parameters and the estimation of other parameters based on performance targets from the Department of Energy SunShot Initiative. This comparison was done for both current and high temperature cases in two configurations: a surround field with an external cylindrical receiver and a north field with a single cavity receiver. There is a fairly dramatic difference between the design point and annual average performance, especially in the solar field and receiver subsystems, and also in energy losses due to the thermal energy storage being full to capacity. Additionally, there are relatively small differences (<2%) in annual average efficiencies between the Base and High Temperature cases, despite an increase in thermal to electric conversion efficiency of over 8%. This is due the increased thermal losses at higher temperature and operational losses due to subsystem start-up and shut-down. Thermal energy storage can mitigate some of these losses by utilizing larger thermal energy storage to ensure that the electric power production system does not need to stop and re-start as often, but solar energy is inherently transient. Economic and cost considerations were not considered here, but will have a significant impact on solar thermal electric power production strategy and sizing.

  6. Optical design of a 4-off-axis-unit Cassegrain ultra-high concentrator photovoltaics module with a central receiver.

    PubMed

    Ferrer-Rodríguez, Juan P; Fernández, Eduardo F; Almonacid, Florencia; Pérez-Higueras, Pedro

    2016-05-01

    Ultra-high concentrator photovoltaics (UHCPV), with concentrations higher than 1000 suns, have been pointed out by different authors as having great potential for being a cost-effective PV technology. This Letter presents a UHCPV Cassegrain-based optical design in which the sunrays are concentrated and sent from four different and independent paraboloid-hyperboloid pairs optical units onto a single central receiver. The optical design proposed has the main advantage of the achievement of ultra-high concentration ratios using relative small mirrors with similar performance values of efficiency, acceptance angle, and irradiance uniformity to other designs.

  7. Receiver subsystem analysis report (RADL Item 4-1). The 10-MWe solar thermal central-receiver pilot plant: Solar-facilities design integration

    NASA Astrophysics Data System (ADS)

    1982-04-01

    The results of thermal hydraulic, design for the stress analyses which are required to demonstrate that the receiver design for the Barstow Solar Pilot Plant satisfies the general design and performance requirements during the plant's design life are presented. Recommendations are made for receiver operation. The analyses are limited to receiver subsystem major structural parts (primary tower, receiver unit core support structure), pressure parts (absorber panels, feedwater, condensate and steam piping/components, flash tank, and steam mainfold) and shielding.

  8. Advances and expansion of Central and Eastern European proteomics.

    PubMed

    Gadher, Suresh Jivan; Kovarova, Hana

    2012-01-01

    Prague, also known as the 'City of a Hundred Spires', which is situated on the bank of River Vltava and is a historical Bohemian capital rich in history and beauty, set the stage for an exciting meeting that brought together high-caliber experts to share their knowledge as well as propagate the central theme and focus on 'Proteomes, Proteomics and Biological Systems'. More than 120 delegates from all over the world attended in pursuit of excellence and enjoyed not only excellent science but also took back home fairy-tale memories of Prague and its offerings. The 5th Central and Eastern European Proteomic Conference was organized in Prague, Czech Republic, on 19-22 September 2011, with resounding success. PMID:22292818

  9. Numerical study of local/regional atmospheric changes caused by a large solar central receiver power plant

    NASA Astrophysics Data System (ADS)

    Bhumralkar, C. M.; Slemmons, A. J.; Nitz, K. C.

    1981-06-01

    A two-dimensional numerical atmospheric mesoscale model with a vertical cross section is applied to study the potential local/regional atmospheric effects of the installation of a 100 MWe solar thermal central receiver power plant in California. The plant comprises heliostats (mirrors) covering a portion of ground surface and reflecting sunlight onto a central receiving tower. The model is able to simulate the changes in surface characteristics associated with the installation of heliostats and other power plant ancillaries and can also simulate the effects of waste heat from cooling towers. The model equations are integrated to simulate typical summer and atypical summer. The results for typical summer conditions at the site and in the surrounding region demonstrate that the power plant has the potential to increase local humidity and wind circulation but cannot induce the formation of clouds or rain. The results for atypical summer conditions show that the solar power plant is potentially able to increase the wind circulation and form clouds and rain. It is noted, however, that the life cycle of such formations is only 2-3 h.

  10. 78 FR 44103 - Announcement of Public Meetings To Receive Comments on Draft Solicitation for Advanced Fossil...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... following technology areas: (a) Advanced resource development, (b) carbon capture, (c) low-carbon power... FR 41046). Persons desiring to submit comments may do so either in writing according to...

  11. Receiver subsystem analysis report (RADL Item 4-1). 10-MWe Solar Thermal Central-Receiver Pilot Plant: solar-facilities design integration

    SciTech Connect

    Not Available

    1982-04-01

    The results are presented of those thermal hydraulic, structural, and stress analyses required to demonstrate that the Receiver design for the Barstow Solar Pilot Plant will satisfy the general design and performance requirements during the plant's design life. Recommendations resulting from those analyses and supporting test programs are presented regarding operation of the receiver. The analyses are limited to receiver subsystem major structural parts (primary tower, receiver unit core support structure), pressure parts (absorber panels, feedwater, condensate and steam piping/components, flash tank, and steam mainfold) and shielding. (LEW)

  12. The pathophysiological mechanism of fluid retention in advanced cancer patients treated with docetaxel, but not receiving corticosteroid comedication

    PubMed Central

    Béhar, A.; Pujade-Lauraine, E.; Maurel, A.; Brun, M. D.; Lagrue, G.; Feuilhade De Chauvin, F.; Oulid-Aissa, D.; Hille, D.

    1997-01-01

    Aims Fluid retention is a phenomenon associated with taxoids. The principal objective of this study was to investigate the pathophysiological mechanism of docetaxel-induced fluid retention in advanced cancer patients. Methods Docetaxel was administered as a 1 h intravenous infusion every 3 weeks, for at least 4–6 consecutive cycles, to patients with advanced breast (n=21) or ovarian (n=3) carcinoma, who had received previous chemotherapy, 21 for advanced disease. Phase II clinical trials have shown that 5 day corticosteroid comedication, starting 1 day before docetaxel infusion, significantly reduces the incidence and severity of fluid retention. This prophylactic corticosteroid regimen is currently recommended for patients receiving docetaxel but was not permitted in this study because of its possible interference with the underlying pathophysiology of the fluid retention. Results Fluid retention occurred in 21 of the 24 patients but was mainly mild to moderate, with only five patients experiencing severe fluid retention. Eighteen patients received symptomatic flavonoid treatment, commonly prescribed after the last cycle. Specific investigations for fluid retention confirmed a relationship between cumulative docetaxel dose and development of fluid retention. Capillary filtration test analysis showed a two-step process for fluid retention generation, with progressive congestion of the interstitial space by proteins and water starting between the second and the fourth cycle, followed by insufficient lymphatic drainage. Conclusions A vascular protector such as micronized diosmine hesperidine with recommended corticosteroid premedication and benzopyrones may be useful in preventing and treating docetaxel-induced fluid retention. PMID:9205828

  13. Waste Receiving and Processing Facility Module 2A: Advanced Conceptual Design Report. Volume 2

    SciTech Connect

    Not Available

    1994-03-01

    This volume presents the Total Estimated Cost (TEC) for the WRAP (Waste Receiving and Processing) 2A facility. The TEC is $81.9 million, including an overall project contingency of 25% and escalation of 13%, based on a 1997 construction midpoint. (The mission of WRAP 2A is to receive, process, package, certify, and ship for permanent burial at the Hanford site disposal facilities the Category 1 and 3 contact handled low-level radioactive mixed wastes that are currently in retrievable storage, and are forecast to be generated over the next 30 years by Hanford, and waste to be shipped to Hanford site from about 20 DOE sites.)

  14. Preliminary Results From the CAUGHT Experiment: Investigation of the North Central Andes Subsurface Using Receiver Functions and Ambient Noise Tomography

    NASA Astrophysics Data System (ADS)

    Ryan, J. C.; Ward, K. M.; Porter, R. C.; Beck, S. L.; Zandt, G.; Wagner, L. S.; Minaya, E.; Tavera, H.

    2011-12-01

    Jamie Ryan, Kevin M. Ward, Ryan Porter, Susan Beck, George Zandt, Lara Wagner, Estela Minaya, and Hernando Tavera The University of Arizona The University of North Carolina San Calixto Observatorio, La Paz, Bolivia IGP, Lima, Peru In order to investigate the interplay between crustal shortening, lithospheric removal, and surface uplift we have deployed 50 broadband seismometers in northwestern Bolivia and southern Peru as part of the interdisciplinary Central Andean Uplift and Geodynamics of High Topography (CAUGHT) project. The morphotectonic units of the central Andes from west to east, consist of the Western Cordillera, the active volcanic arc, the Altiplano, an internally drained basin (~4 km elevation), the Eastern Cordillera, the high peaks (~6 km elevation) of an older fold and thrust belt, the Subandean zone, the lower elevation active fold and thrust belt, and the foreland Beni basin. Between northwestern Bolivia and southern Peru, the Altiplano pinches out north of Lake Titicaca as the Andes narrow northward. The CAUGHT seismic instruments were deployed between 13° to 18° S latitudes to investigate the crust and mantle lithosphere of the central Andes in this transitional zone. In northwest Bolivia, perpendicular to the strike of the Andes, there is a total of 275 km of documented upper crustal shortening (15° to 17°S) (McQuarrie et al, 2008). Associated with the shortening is crustal thickening and possibly lithospheric removal as the thickening lithospheric root becomes unstable. An important first order study is to compare upper crustal shortening estimates with present day crustal thickness. To estimate crustal thickness, we have calculated receiver functions using an iterative deconvolution method and used common conversion point stacking along the same profile as the geologically based shortening estimates. In our preliminary results, we observed a strong P to S conversion corresponding to the Moho at approximately 60-65 km depth underneath the

  15. Receiver function constraints on crustal seismic velocities and partial melting in the Red Sea Rift, Central Afar

    NASA Astrophysics Data System (ADS)

    Reed, C. A.; Almadani, S.; Gao, S. S.; Elsheikh, A. A.; Cherie, S.; Thurmond, A. K.; Liu, K. H.

    2013-12-01

    The Afar Depression is currently a unique locale for the investigation of crustal and mantle processes involved in the transition from continental to oceanic rifting. To provide high-quality images of the crust and upper mantle beneath the Red Sea Rift in Central Afar, we deployed an array of 18 broadband seismic stations in 2010 and 2011. Here we report receiver function stacking results to investigate crustal properties of this presumably incipient oceanic rift. Stacking of approximately 2200 radial receiver functions along the ~200 km long array reveals an average crustal thickness of 22 km, ranging from nearly 18 km within the Red Sea Rift axis to approximately 30 km within the overlap zone between the Red Sea and Gulf of Aden rift axes. The resulting anomalously high Vp/Vs ratios systematically decrease toward the northeast, ranging from 2.40 southwest of the Tendaho Graben to 1.85 within the overlap zone. We utilize theoretical Vp and melt fraction relationships to constrain a highly reduced average crustal P-velocity of 5.0 km/s within the rift axis, which is characterized by a melt percentage of ~11% confined primarily to the lower crust while the overlap zone contains relatively minor quantities of partial melt. An observed asymmetric distribution of high Vp/Vs values within the Tendaho Graben, as well as regionally maximum values on the southwestern rift flank, suggest crustal magmas either delivered from off-axis subcrustal magma chambers or as material present as residuum from the Red Sea Rift axis migration. Comparisons of these crustal properties beneath the Red Sea Rift and those found beneath mature mid-ocean ridges suggest the locus of extensional strain within the Central Afar is currently diffuse and in the process of localizing toward the Tendaho Graben accompanying the northeastward migration of the Afar Triple Junction.

  16. 41 CFR 302-9.12 - May I receive an advance of funds for transportation and emergency or temporary storage of my POV?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false May I receive an advance... PRIVATELY OWNED VEHICLE General Rules § 302-9.12 May I receive an advance of funds for transportation...

  17. Associations of ATM Polymorphisms With Survival in Advanced Esophageal Squamous Cell Carcinoma Patients Receiving Radiation Therapy

    SciTech Connect

    Du, Zhongli; Zhang, Wencheng; Zhou, Yuling; Yu, Dianke; Chen, Xiabin; Chang, Jiang; Qiao, Yan; Zhang, Meng; Huang, Ying; Wu, Chen; Xiao, Zefen; Tan, Wen; and others

    2015-09-01

    Purpose: To investigate whether single nucleotide polymorphisms (SNPs) in the ataxia telangiectasia mutated (ATM) gene are associated with survival in patients with esophageal squamous cell carcinoma (ESCC) receiving radiation therapy or chemoradiation therapy or surgery only. Methods and Materials: Four tagSNPs of ATM were genotyped in 412 individuals with clinical stage III or IV ESCC receiving radiation therapy or chemoradiation therapy, and in 388 individuals with stage I, II, or III ESCC treated with surgery only. Overall survival time of ESCC among different genotypes was estimated by Kaplan-Meier plot, and the significance was examined by log-rank test. The hazard ratios (HRs) and 95% confidence intervals (CIs) for death from ESCC among different genotypes were computed by a Cox proportional regression model. Results: We found 2 SNPs, rs664143 and rs664677, associated with survival time of ESCC patients receiving radiation therapy. Individuals with the rs664143A allele had poorer median survival time compared with the rs664143G allele (14.0 vs 20.0 months), with the HR for death being 1.45 (95% CI 1.12-1.89). Individuals with the rs664677C allele also had worse median survival time than those with the rs664677T allele (14.0 vs 23.5 months), with the HR of 1.57 (95% CI 1.18-2.08). Stratified analysis showed that these associations were present in both stage III and IV cancer and different radiation therapy techniques. Significant associations were also found between the SNPs and locosregional progression or progression-free survival. No association between these SNPs and survival time was detected in ESCC patients treated with surgery only. Conclusion: These results suggest that the ATM polymorphisms might serve as independent biomarkers for predicting prognosis in ESCC patients receiving radiation therapy.

  18. On-sun testing of an advanced falling particle receiver system

    NASA Astrophysics Data System (ADS)

    Ho, Clifford K.; Christian, Joshua M.; Yellowhair, Julius; Siegel, Nathan; Jeter, Sheldon; Golob, Matthew; Abdel-Khalik, Said I.; Nguyen, Clayton; Al-Ansary, Hany

    2016-05-01

    A 1 MWth high-temperature falling particle receiver was constructed and tested at the National Solar Thermal Test Facility at Sandia National Laboratories. The continuously recirculating system included a particle elevator, top and bottom hoppers, and a cavity receiver that comprised a staggered array of porous chevron-shaped mesh structures that slowed the particle flow through the concentrated solar flux. Initial tests were performed with a peak irradiance of ~300 kW/m2 and a particle mass flow rate of 3.3 kg/s. Peak particle temperatures reached over 700 °C near the center of the receiver, but the particle temperature increase near the sides was lower due to a non-uniform irradiance distribution. At a particle inlet temperature of ~440 °C, the particle temperature increase was 27 °C per meter of drop length, and the thermal efficiency was ~60% for an average irradiance of 110 kW/m2. At an average irradiance of 211 kW/m2, the particle temperature increase was 57.1 °C per meter of drop length, and the thermal efficiency was ~65%. Tests with higher irradiances are being performed and are expected to yield greater particle temperature increases and efficiencies.

  19. Preliminary design of the Carrisa Plains solar central receiver power plant. Volume III, Book 1. Design description

    SciTech Connect

    Not Available

    1983-12-31

    The design of the 30 MWe central receiver solar power plant to be located at Carrisa Plains, San Luis Obispo County, California, is summarized. The plant uses a vertical flat-panel (billboard solar receiver located at the top of a tower to collect solar energy redirected by approximately 1900 heliostats located to the north of the tower. The solar energy is used to heat liquid sodium pumped from ground level from 610 to 1050/sup 0/F. The power conversion system is a non-reheat system, cost-effective at this size level, and designed for high-efficiency performance in an application requiring daily startup. Successful completion of this project will lead to power generation starting in 1986. This report discusses in detail the design of the collector system, heat transport system, thermal storage subsystem, heat transport loop, steam generation subsystem, electrical, instrumentation, and control systems, power conversion system, master control system, and balance of plant. The performance, facility cost estimate and economic analysis, and development plan are also discussed.

  20. SUNBURN: A computer code for evaluating the economic viability of hybrid solar central receiver electric power plants

    SciTech Connect

    Chiang, C.J.

    1987-06-01

    The computer program SUNBURN simulates the annual performance of solar-only, solar-hybrid, and fuel-only electric power plants. SUNBURN calculates the levelized value of electricity generated by, and the levelized cost of, these plants. Central receiver solar technology is represented, with molten salt as the receiver coolant and thermal storage medium. For each hour of a year, the thermal energy use, or dispatch, strategy of SUNBURN maximizes the value of electricity by operating the turbine when the demand for electricity is greatest and by minimizing overflow of thermal storage. Fuel is burned to augment solar energy if the value of electricity generated by using fuel is greater than the cost of the fuel consumed. SUNBURN was used to determine the optimal power plant configuration, based on value-to-cost ratio, for dates of initial plant operation from 1990 to 1998. The turbine size for all plants was 80 MWe net. Before 1994, fuel-only was found to be the preferred plant configuration. After 1994, a solar-only plant was found to have the greatest value-to-cost ratio. A hybrid configuration was never found to be better than both fuel-only and solar-only configurations. The value of electricity was calculated as The Southern California Edison Company's avoided generation costs of electricity. These costs vary with time of day. Utility ownership of the power plants was assumed. The simulation was performed using weather data recorded in Barstow, California, in 1984.

  1. Clinical and radiographic evaluation of maxillary central incisors exposure in patients undergoing maxillary advancement

    PubMed Central

    Trento, Guilherme dos Santos; Bernabé, Felipe Bueno Rosettti; da Costa, Delson João; Rebellato, Nelson Luis Barbosa; Klüppel, Leandro Eduardo; Scariot, Rafaela

    2015-01-01

    Abstract Introduction: Patients with dentofacial deformities may undergo orthodontic or orthodontic-surgical treatment. Both modalities can affect esthetics. Objective: This study aims to evaluate clinical and radiographic changes in exposure of maxillary central incisors occurring after orthognathic surgery for maxillary advancement. Methods: A total of 17 patients who underwent orthognathic surgery for maxillary advancement between September, 2010 and July, 2011 were selected. Exposure of maxillary central incisors was evaluated clinically and by lateral cephalograms. Measurements were taken one week before and three months after surgery. Data were paired in terms of sex, age, nasolabial angle, height and thickness of the upper lip, the amount of maxillary advancement, clinical exposure and inclination of maxillary central incisor by statistical tests (CI 95%). Results: After maxillary advancement, incisor clinical exposure had increased even with relaxed lips and under forced smile. Moreover, there was a mean increase of 23.33% revealed by lateral cephalograms. There was an inverse correlation between upper lip thickness and incisors postsurgical exposure revealed by radiographic images (p = 0.002). Conclusions: Significant changes in the exposure of maxillary central incisors occur after maxillary advancement, under the influence of some factors, especially lip thickness. PMID:26691970

  2. Overview on advances in radiometric receiver design and technology: application to the MIMR

    NASA Astrophysics Data System (ADS)

    Bordi, Roberto; L'Abbate, Michele; Spera, Paolo

    1994-12-01

    MIMR (Multifrequency Imaging Microwave Radiometer) is an instrument under development for the European Space Agency (ESA) by the European Industry, with Alenia Spazio as Prime Contractor. It is a conical scanning passive microwave radiometer, which shall measure the Earth surface brightness temperature by processing the received electro- magnetic Earth surface radiation in linear polarization. Its output products will be of prime importance for monitoring of the environment, and will provide useful data for climatology and meteorology with day and night operation capabilities and near global daily coverage. The experience gained through various programs since 1972 with NIMBUS satellite's series utilizing ESMR, NEMS, SCAMS, SMMR instruments and DMSP-Block 5D-2 satellite with on-board SSM/I instrument led to the MIMR concept with better performance than the instruments already flown. MIMR has successfully passed a design phase, which has established an instrument baseline suited for accommodation on either the NASA EOS or ESA METOP spacecrafts, and a breadboarding activity devoted to key items. A Demonstrator model of the Instrument is currently under development, which shall prove by test its challenging performance: it will be representative of the flight design, performing measurements at 6.8, 36.5 and 89.0 GHz. Within this paper emphasis will be put on the receivers key design topics, as driven by performance and technology trade-offs, with an overview of the achieved performance in the frame of development activity.

  3. Health: support provided and received in advanced old age. A five-year follow-up.

    PubMed

    Armi, F; Guilley, E; Lalive d'Epinay, C J

    2008-02-01

    While research focuses mainly on support provided to the elderly, this paper deals with the very old as a support provider to his family as much as a care recipient from both his family and a formal network. We hypothesize that elders with declining health will try to maintain the provision of services, even when they require and receive help.A total of 340 octogenarians from the Swiss Interdisciplinary Longitudinal Study on the Oldest Old (SWILSOO) were interviewed up to five times over five years (N=1225 interviews). A multilevel model was applied to assess the effects of health, controlled for socio-demographic and family network variables, on the frequency of services that the old persons provided to their family and received from their family and formal networks. Health is operationalized in three statuses: ADL-dependent, ADL-independent frail, and robust.While the recourse to the informal network increased progressively with the process of frailty, the recourse to the formal network drastically increased for ADL-dependent individuals. Being ADL-dependent seriously altered the capacity to provide services, but ADL-independent frail persons were providers with the same frequency as the robust oldest old, showing their ability to preserve a principle of reciprocity in their exchanges with their family network. This continuity of roles may help frail persons to maintain their self-esteem and well-being.

  4. Advanced Stirling receiver development program, phase 1. Final report, December 1988-July 1990

    SciTech Connect

    Lurio, C.A.

    1990-07-01

    Critical technology experiments were designed and developed to evaluate the Stirling cavity heat pipe receiver for a space solar power system. Theoretical criteria were applied to the design of a module for containing energy storage phase change material while avoiding thermal ratcheting. Zero-g drop tower tests, without phase change, were conducted to affirm that the bubble location required to avoid ratcheting could be achieved without the use of container materials that are wetted by the phase change material. A full scale module was fabricated, but not tested. A fabrication method was successfully developed for the sodium evaporator dome, with a sintered screen wick, to be used as the focal point for the receiver. Crushing of the screen during hydroforming was substantially reduced over the results of other researchers by using wax impregnation. Superheating of the sodium in the wick under average flux conditions is expected to be under 10K. A 2000K furnace which will simulate solar flux conditions for testing the evaporator dome was successfully built and tested.

  5. Performance and reliability of a 30-kW triple-junction photovoltaic receiver for 500X concentrator dish or central receiver applications

    NASA Astrophysics Data System (ADS)

    Verlinden, P. J.; Lewandowski, A.; Lasich, J. B.

    2006-08-01

    Over the last 15 years, Solar Systems has developed a dense array receiver PV technology for 500X concentrator reflective dish applications. This concentrator PV technology has been successfully deployed at six different locations in Australia, counting for about 1 MWp of installed peak power. A new Multijunction III-V receiver to replace the current silicon Point-Contact solar cells has recently been developed. The new receiver technology is based on high-efficiency (> 32%) Concentrator Ultra Triple Junction (CUTJ) solar cells from Spectrolab, resulting in system power and energy performance improvement of more than 50% compared to the silicon cells. The 0.235 m2 concentrator PV receiver, designed for continuous 500X operation, is composed of 64 dense array modules, and made of series and parallel-connected solar cells, totaling approximately 1,500 cells. The individual dense array modules have been tested under high intensity pulsed light, as well as with concentrated sunlight at the Solar Systems research facility and at the National Renewable Energy Laboratory's High Flux Solar Furnace. The efficiency of the dense array modules ranges from 30% to 36% at 500X (50 W/cm2, AM1.5D low AOD, 21°C). The temperature coefficients for power, voltage and current, as well as the influence of Air Mass on the cell responsivity, were measured. The reliability of the dense array multijunction III-V modules has been studied with accelerated aging tests, such as thermal cycling, damp heat and high-temperature soak, and with real-life high-intensity exposure. The first 33-kWp multijunction III-V receiver was recently installed in a Solar Systems dish and tested in real-life 500X concentrated sunlight conditions. Receiver efficiencies of 30.3% and 29.0% were measured at Standard Operating Conditions and Normal Operating Conditions respectively.

  6. Waste Receiving and Processing Facility Module 2A: Advanced Conceptual Design Report. Volume 1

    SciTech Connect

    Not Available

    1994-03-01

    This ACDR was performed following completed of the Conceptual Design Report in July 1992; the work encompassed August 1992 to January 1994. Mission of the WRAP Module 2A facility is to receive, process, package, certify, and ship for permanent burial at the Hanford site disposal facilities the Category 1 and 3 contact handled low-level radioactive mixed wastes that are currently in retrievable storage at Hanford and are forecast to be generated over the next 30 years by Hanford, and waste to be shipped to Hanford from about DOE sites. This volume provides an introduction to the ACDR process and the scope of the task along with a project summary of the facility, treatment technologies, cost, and schedule. Major areas of departure from the CDR are highlighted. Descriptions of the facility layout and operations are included.

  7. User's manual for DELSOL2: a computer code for calculating the optical performance and optimal system design for solar-thermal central-receiver plants

    SciTech Connect

    Dellin, T.A.; Fish, M.J.; Yang, C.L.

    1981-08-01

    DELSOL2 is a revised and substantially extended version of the DELSOL computer program for calculating collector field performance and layout, and optimal system design for solar thermal central receiver plants. The code consists of a detailed model of the optical performance, a simpler model of the non-optical performance, an algorithm for field layout, and a searching algorithm to find the best system design. The latter two features are coupled to a cost model of central receiver components and an economic model for calculating energy costs. The code can handle flat, focused and/or canted heliostats, and external cylindrical, multi-aperture cavity, and flat plate receivers. The program optimizes the tower height, receiver size, field layout, heliostat spacings, and tower position at user specified power levels subject to flux limits on the receiver and land constraints for field layout. The advantages of speed and accuracy characteristic of Version I are maintained in DELSOL2.

  8. Strategic Advancement: How a Centralized Services Department Can Do More than Just Support Fund Raisers.

    ERIC Educational Resources Information Center

    Hardy, Roger

    1991-01-01

    Advancement services, the group of functions that support fundraising and alumni relations, has evolved to include donor relations and stewardship, data processing analysis and programing, budget development and analysis, and event management. Centralizing these services under a single manager can lead to greater productivity. (MSE)

  9. The value of lactate dehydrogenase serum levels as a prognostic and predictive factor for advanced pancreatic cancer patients receiving sorafenib

    PubMed Central

    Faloppi, Luca; Bianconi, Maristella; Giampieri, Riccardo; Sobrero, Alberto; Labianca, Roberto; Ferrari, Daris; Barni, Sandro; Aitini, Enrico; Zaniboni, Alberto; Boni, Corrado; Caprioni, Francesco; Mosconi, Stefania; Fanello, Silvia; Berardi, Rossana; Bittoni, Alessandro; Andrikou, Kalliopi; Cinquini, Michela; Torri, Valter; Scartozzi, Mario; Cascinu, Stefano

    2015-01-01

    Although lactate dehydrogenase (LDH) serum levels, indirect markers of angiogenesis, are associated with a worse outcome in several tumours, their prognostic value is not defined in pancreatic cancer. Moreover, high levels are associated even with a lack of efficacy of tyrosine kinase inhibitors, contributing to explain negative results in clinical trials. We assessed the role of LDH in advanced pancreatic cancer receiving sorafenib. Seventy-one of 114 patients included in the randomised phase II trial MAPS (chemotherapy plus or not sorafenib) and with available serum LDH levels, were included in this analysis. Patients were categorized according to serum LDH levels (LDH ≤vs.> upper normal rate). A significant difference was found in progression free survival (PFS) and in overall survival (OS) between patients with LDH values under or above the cut-off (PFS: 5.2 vs. 2.7 months, p = 0.0287; OS: 10.7 vs. 5.9 months, p = 0.0021). After stratification according to LDH serum levels and sorafenib treatment, patients with low LDH serum levels treated with sorafenib showed an advantage in PFS (p = 0.05) and OS (p = 0.0012). LDH appears to be a reliable parameter to assess the prognosis of advanced pancreatic cancer patients, and it may be a predictive parameter to select patients candidate to receive sorafenib. PMID:26397228

  10. The value of lactate dehydrogenase serum levels as a prognostic and predictive factor for advanced pancreatic cancer patients receiving sorafenib.

    PubMed

    Faloppi, Luca; Bianconi, Maristella; Giampieri, Riccardo; Sobrero, Alberto; Labianca, Roberto; Ferrari, Daris; Barni, Sandro; Aitini, Enrico; Zaniboni, Alberto; Boni, Corrado; Caprioni, Francesco; Mosconi, Stefania; Fanello, Silvia; Berardi, Rossana; Bittoni, Alessandro; Andrikou, Kalliopi; Cinquini, Michela; Torri, Valter; Scartozzi, Mario; Cascinu, Stefano

    2015-10-27

    Although lactate dehydrogenase (LDH) serum levels, indirect markers of angiogenesis, are associated with a worse outcome in several tumours, their prognostic value is not defined in pancreatic cancer. Moreover, high levels are associated even with a lack of efficacy of tyrosine kinase inhibitors, contributing to explain negative results in clinical trials. We assessed the role of LDH in advanced pancreatic cancer receiving sorafenib. Seventy-one of 114 patients included in the randomised phase II trial MAPS (chemotherapy plus or not sorafenib) and with available serum LDH levels, were included in this analysis. Patients were categorized according to serum LDH levels (LDH ≤ vs.> upper normal rate). A significant difference was found in progression free survival (PFS) and in overall survival (OS) between patients with LDH values under or above the cut-off (PFS: 5.2 vs. 2.7 months, p = 0.0287; OS: 10.7 vs. 5.9 months, p = 0.0021). After stratification according to LDH serum levels and sorafenib treatment, patients with low LDH serum levels treated with sorafenib showed an advantage in PFS (p = 0.05) and OS (p = 0.0012). LDH appears to be a reliable parameter to assess the prognosis of advanced pancreatic cancer patients, and it may be a predictive parameter to select patients candidate to receive sorafenib. PMID:26397228

  11. Early identification of non-responding locally advanced breast tumors receiving neoadjuvant chemotherapy

    NASA Astrophysics Data System (ADS)

    Van de Giessen, Martijn; Schaafsma, Boudewijn E.; Charehbili, Ayoub; Smit, Vincent T. H. B. M.; Kroep, Judith R.; Lelieveldt, Boudewijn P. F.; Liefers, Gerrit-Jan; Chan, Alan; Löwik, Clemens W. G. M.; Dijkstra, Jouke; van de Velde, Cornelis J. H.; Wasser, Martin N. J. M.; Vahrmeijer, Alexander L.

    2015-02-01

    Diffuse optical spectroscopy (DOS) may be advantageous for monitoring tumor response during chemotherapy treatment, particularly in the early treatment stages. In this paper we perform a second analysis on the data of a clinical trial with 25 breast cancer patients that received neoadjuvant chemotherapy. Patients were monitored using delayed contrast enhanced MRI and additionally with diffuse optical spectroscopy at baseline, after 1 cycle of chemotherapy, halfway therapy and before surgery. In this analysis hemoglobin content between tumor tissue and healthy tissue of the same breast is compared on all four monitoring time points. Furthermore, the predictive power of the tumor-healthy tissue difference of HbO2 for non-responder prediction is assessed. The difference in HbO2 content between tumor and healthy tissue was statistically significantly higher in responding tumors than in non-responding tumors at baseline (10.88 vs -0.57 μM, P=0.014) and after one cycle of chemotherapy (6.45 vs -1.31 μM, P=0.048). Before surgery this difference had diminished. In the data of this study, classification on the HbO2 difference between tumor and healthy tissue was able to predict tumor (non-)response at baseline and after 1 cycle with an area-under-curve of 0.95 and 0.88, respectively. While this result suggests that tumor response can be predicted before chemotherapy onset, one should be very careful with interpreting these results. A larger patient population is needed to confirm this finding.

  12. Review of hydraulic fracture mapping using advanced accelerometer-based receiver systems

    SciTech Connect

    Warpinski, N.R.; Uhl, J.E.; Engler, B.P.

    1997-03-01

    Hydraulic fracturing is an important tool for natural gas and oil exploitation, but its optimization has been impeded by an inability to observe how the fracture propagates and what its overall dimensions are. The few experiments in which fractures have been exposed through coring or mineback have shown that hydraulic fractures are complicated multi-stranded structures that may behave much differently than currently predicted by models. It is clear that model validation, fracture optimization, problem identification and solution, and field development have all been encumbered by the absence of any ground truth information on fracture behavior in field applications. The solution to this problem is to develop techniques to image the hydraulic fracture in situ from either the surface, the treatment well, or offset wells. Several diagnostic techniques have been available to assess individual elements of the fracture geometry, but most of these techniques have limitations on their usefulness. For example, tracers and temperature logs can only measure fracture height at the wellbore, well testing and production history matching provide a productive length which may or may not be different from the true fracture length, and tiltmeters can provide accurate information on azimuth and type of fracture (horizontal or vertical), but length and height can only be extracted from a non-unique inversion of the data. However, there is a method, the microseismic technique, which possesses the potential for imaging the entire hydraulic fracture and, more importantly, its growth history. This paper discusses application of advanced technology to the microseismic method in order to provide detailed accurate images of fractures and their growth processes.

  13. The Under-side of the Andes: Using Receiver Functions to Map the North Central Andean Subsurface

    NASA Astrophysics Data System (ADS)

    Ryan, J. C.; Beck, S. L.; Zandt, G.; Wagner, L. S.; Minaya, E.; Tavera, H.

    2012-12-01

    The Central Andean Uplift and Geodynamics of High Topography (CAUGHT) project is an interdisciplinary project to investigate connections between lithospheric removal, crustal shortening and surface uplift in the northern Bolivia and southern Peru region of the South American Andean orogen. The central Andes are defined by six major tectonomorphic provinces; the forearc, the volcanically active Western Cordillera (WC, ~6 km elevation), the internally drained Altiplano (~4 km elevation), an inactive fold and thrust belt in the Eastern Cordillera (EC, ~6 km elevation), a lower elevation active fold and thrust belt in the Subandean (SA) zone and the Beni, a foreland basin. Forty seismic stations installed for the CAUGHT project were deployed between 13° and 18° S latitude, covering the transition zone where the Altiplano region pinches out in southern Peru, in an effort to better constrain the changing character of the crust and mantle lithosphere. Geologic studies across the northern Bolivian portion of the eastern Andean margin (15-17° S) have documented a total of 275 km of upper crustal shortening (McQuarrie et al, Tectonics, v27, 2008), which may be associated with crustal thickening and/or the removal of lithospheric material as a thickened lithosphere root becomes unstable. For this receiver function (converted wave) study, we have little coverage in the forearc and foreland, ~75 km spacing in most of the array, and a relatively dense ~20 km spaced profile along the Charaña-La Paz-Yucumo transect, the eastern portion of which is nearly coincident with the balanced cross-section of McQuarrie et al. (2008). Using the first year of available data, more than 1200 receiver functions have been calculated using an iterative deconvolution method, and stacked using the common conversion point (CCP) method, along profiles parallel to and nearly coincident to those used for the geologic shortening estimates. We identified arrivals for the Moho and generated a 3D map of

  14. Simultaneous Inversion of Receiver Functions, Surface-wave Dispersion, and Gravity observations for Lithospheric Structure Beneath the Central United States

    NASA Astrophysics Data System (ADS)

    Chai, C.; Ammon, C. J.; Herrmann, R. B.

    2013-12-01

    The Mississippi Embayment (ME) region is a first-order feature in North American geology and the location of the 1811-1812 New Madrid earthquake sequence. After decades of study, we still lack fundamental knowledge of how upper crustal phenomena relate to deeper crustal and mantle processes that likely exert significant control on the regional tectonics. The migration of the EarthScope TA provides a unique opportunity to illuminate the subsurface and to explore the extent to which lithospheric heterogeneity influences the dynamic processes associated with the ME. Our work is part of Northern Embayment Lithosphere Experiment (NELE), a lithospheric-scale passive array experiment built and operated around the broader-scale TA and regional seismic networks. Even with a dense network, tightly constraining subsurface 3D geologic variations in this region is a challenge. We combine the complementary sensitivities P-wave receiver functions, surface-wave dispersion, and wavenumber-filtered satellite gravity variations to constrain lateral variations in shear-wave speed beneath the region. Since some of the data are still being collected, right now we have performed an inversion with less resolution over a boarder region that covers the central and eastern of US, to begin to image the ME region. A joint inversion provides more constraints than individual inversions, and generally produces a more robust estimate of the subsurface structure. We use a hybrid 1D-3D inversion. The subsurface model is parameterized with shear-wave speed (the primary sensitivity of the surface-wave dispersion and receiver function waveforms) within one-degree cells and variable thickness layers. We relate P-wave speed and density variations to shear-speed using a range of velocity ratios and density-speed relations and we constrain the model to be laterally and vertically smooth. Results from a preliminary inversion show the broad ME, low shear-wave speeds in the uppermost crust are underlain by a

  15. Prognostic Significance of Central Pulse Pressure for Mortality in Patients With Coronary Artery Disease Receiving Repeated Percutaneous Coronary Intervention

    PubMed Central

    Lin, Mao-Jen; Chen, Chun-Yu; Lin, Hau-De; Lin, Chung-Sheng; Wu, Han-Ping

    2016-01-01

    Abstract Coronary artery disease (CAD) is a life-threatening medical emergency which needs urgent medical attention. Percutaneous coronary intervention (PCI) is common and necessary for patients with CAD, but it has not completely evaluated in cases with repeated PCI. Therefore, the aim of this study was to examine the risk factors and prognosis in patients with CAD requiring repeated PCI. This is a prospective observational study. A total of 1126 patients with CAD requiring PCI took part in this study. Clinical parameters including baseline characteristics, hemodynamic data, location of vascular lesions, SYNTAX score, left ventricular ejection fraction, central pulse pressure (CPP), central aortic systolic pressure (CSP), risk factors, and invasive strategies were analyzed to identify the risk factors for patients requiring repeated PCI. We further analyzed the prognosis, including risk for myocardial infarction (MI), cardiovascular (CV) mortality, and all-cause mortality, in patients with repeated PCI. Among patients with PCI, 276 received repeated PCI. Patients in the repeated PCI group had a higher CPP (66.7 vs 62.5 mm Hg; P = 0.006), CSP (139.9 vs 135.9 mm Hg; P = 0.017), and male preponderance (P = 0.012). Drugs including diuretics, beta-blockers (BBs), angiotensin-converting enzyme inhibitors (ACEIs), and aspirin were all used more frequently in the repeated PCI group (all P < 0.05). Freedom from MI was lower in the repeated PCI group than in the single PCI group (P < 0.001). Logistic regression revealed that CPP, CSP, number of diseased vessels, male sex, usage of diuretics, BBs, ACEIs, and MI were all predictors for requiring repeated PCI (all P < 0.05). In addition, CPP was a predictor for MI attack, CV mortality, and all-cause mortality in the repeated PCI group (P = 0.010, P = 0.041, P = 0.004, respectively). Elevated CPP, CSP, male sex, multiple diseased vessels, and the usage of diuretics, BBs, ACEIs, and MI

  16. Prognostic Significance of Central Pulse Pressure for Mortality in Patients With Coronary Artery Disease Receiving Repeated Percutaneous Coronary Intervention.

    PubMed

    Lin, Mao-Jen; Chen, Chun-Yu; Lin, Hau-De; Lin, Chung-Sheng; Wu, Han-Ping

    2016-03-01

    Coronary artery disease (CAD) is a life-threatening medical emergency which needs urgent medical attention. Percutaneous coronary intervention (PCI) is common and necessary for patients with CAD, but it has not completely evaluated in cases with repeated PCI. Therefore, the aim of this study was to examine the risk factors and prognosis in patients with CAD requiring repeated PCI. This is a prospective observational study. A total of 1126 patients with CAD requiring PCI took part in this study. Clinical parameters including baseline characteristics, hemodynamic data, location of vascular lesions, SYNTAX score, left ventricular ejection fraction, central pulse pressure (CPP), central aortic systolic pressure (CSP), risk factors, and invasive strategies were analyzed to identify the risk factors for patients requiring repeated PCI. We further analyzed the prognosis, including risk for myocardial infarction (MI), cardiovascular (CV) mortality, and all-cause mortality, in patients with repeated PCI. Among patients with PCI, 276 received repeated PCI. Patients in the repeated PCI group had a higher CPP (66.7 vs 62.5 mm Hg; P = 0.006), CSP (139.9 vs 135.9 mm Hg; P = 0.017), and male preponderance (P = 0.012). Drugs including diuretics, beta-blockers (BBs), angiotensin-converting enzyme inhibitors (ACEIs), and aspirin were all used more frequently in the repeated PCI group (all P < 0.05). Freedom from MI was lower in the repeated PCI group than in the single PCI group (P < 0.001). Logistic regression revealed that CPP, CSP, number of diseased vessels, male sex, usage of diuretics, BBs, ACEIs, and MI were all predictors for requiring repeated PCI (all P < 0.05). In addition, CPP was a predictor for MI attack, CV mortality, and all-cause mortality in the repeated PCI group (P = 0.010, P = 0.041, P = 0.004, respectively). Elevated CPP, CSP, male sex, multiple diseased vessels, and the usage of diuretics, BBs, ACEIs, and MI were

  17. Comparison of the performance of two measures of central adiposity among apparently healthy Nigerians using the receiver operating characteristic analysis

    PubMed Central

    Okafor, Christian Ifedili; Fasanmade, Olufemi; Ofoegbu, Esther; Ohwovoriole, Augustine Efedaye

    2011-01-01

    Objective: To compare the performance of waist circumference (WC) and waist-to-hip ratio (WHR) in predicting the presence of cardiovascular risk factors (hypertension and generalized obesity) in an apparently healthy population. Materials and Methods: We recruited 898 apparently healthy subjects (318 males and 580 females) of the Igbo ethnic group resident in Enugu (urban), Southeast Nigeria. Data collection was done using the World Health Organization Stepwise approach to Surveillance of risk factors (STEPS) instrument. Subjects had their weight, height, waist and hip circumferences, systolic and diastolic blood pressures measured according to the guidelines in the step 2 of STEPS instrument. Generalized obesity and hypertension were defined using body mass index (BMI) and JNC 7 classifications, respectively. Quantitative and qualitative variables were analyzed using t-test and Chi-square analysis, respectively, while the performance of WC and WHR was compared using the Receiver Operating Characteristic (ROC) analysis. P value was set at <0.05. Results: The mean age of the subjects was 48.7 (12.9) years. Central obesity was found in 76.9% and 66.5% of subjects using WHR and WC, respectively. WC had a significantly higher area under the curve (AUC) than WHR in all the cardiovascular risk groups, namely, generalized obesity (AUC = 0.88 vs. 0.62), hypertension alone (AUC = 0.60 vs. 0.53), and both generalized obesity and hypertension (AUC = 0.86 vs. 0.57). Conclusion: WC performed better than WHR in predicting the presence of cardiovascular risk factors. Being a simple index, it can easily be measured in routine clinic settings without the need for calculations or use of cumbersome techniques. PMID:22029004

  18. Advanced glycation end products measured by skin autofluorescence in a population with central obesity.

    PubMed

    den Engelsen, Corine; van den Donk, Maureen; Gorter, Kees J; Salomé, Philippe L; Rutten, Guy E

    2012-01-01

    Accumulation of advanced glycation end products (AGEs) is enhanced by chronic hyperglycemia and oxidative stress and this process may contribute to the pathogenesis of vascular disease. Skin autofluorescence (AF), a measure of accumulation of AGEs in skin collagen, is associated with vascular disease in patients with diabetes.   Because central obesity enhances oxidative stress people with central obesity might already have increased accumulation of AGEs before diabetes or cardiovascular disease become manifest. To test this hypothesis, we compared the distribution of skin AF and its association with clinical and biochemical parameters in individuals with and without central obesity. Skin AF was measured by a validated AGE Reader in 816 persons with and 431 persons without central obesity, aged 20-70 y. Mean skin AF increased with age and smoking and was higher in centrally obese individuals compared with non-obese individuals (p = 0.001, after adjustment for age and smoking p = 0.13). Mean skin AF in the subgroups without central obesity and without other risk factors (n = 106), central obesity without other risk factors (n = 74) and central obesity with other risk factors (n = 742) was 1.63 ± 0.37, 1.74 ± 0.44 and 1.87 ± 0.43 AU, respectively (p for trend < 0.001, after adjustment for age and smoking p for trend = 0.12). In the group with central obesity age, current smoking, alcohol consumption, waist circumference, creatinine clearance and hs-CRP were independently associated with skin AF (R(2) = 29.4%). Waist circumference hardly contributed to the explained variance. The relationship between waist circumference and skin AF is not as obvious as we hypothesized.

  19. Advanced glycation end products measured by skin autofluorescence in a population with central obesity.

    PubMed

    den Engelsen, Corine; van den Donk, Maureen; Gorter, Kees J; Salomé, Philippe L; Rutten, Guy E

    2012-01-01

    Accumulation of advanced glycation end products (AGEs) is enhanced by chronic hyperglycemia and oxidative stress and this process may contribute to the pathogenesis of vascular disease. Skin autofluorescence (AF), a measure of accumulation of AGEs in skin collagen, is associated with vascular disease in patients with diabetes.   Because central obesity enhances oxidative stress people with central obesity might already have increased accumulation of AGEs before diabetes or cardiovascular disease become manifest. To test this hypothesis, we compared the distribution of skin AF and its association with clinical and biochemical parameters in individuals with and without central obesity. Skin AF was measured by a validated AGE Reader in 816 persons with and 431 persons without central obesity, aged 20-70 y. Mean skin AF increased with age and smoking and was higher in centrally obese individuals compared with non-obese individuals (p = 0.001, after adjustment for age and smoking p = 0.13). Mean skin AF in the subgroups without central obesity and without other risk factors (n = 106), central obesity without other risk factors (n = 74) and central obesity with other risk factors (n = 742) was 1.63 ± 0.37, 1.74 ± 0.44 and 1.87 ± 0.43 AU, respectively (p for trend < 0.001, after adjustment for age and smoking p for trend = 0.12). In the group with central obesity age, current smoking, alcohol consumption, waist circumference, creatinine clearance and hs-CRP were independently associated with skin AF (R(2) = 29.4%). Waist circumference hardly contributed to the explained variance. The relationship between waist circumference and skin AF is not as obvious as we hypothesized. PMID:22870350

  20. Phenytoin toxicity in a patient receiving concomitant use of phenytoin and S-1 plus cisplatin chemotherapy for advanced gastric cancer.

    PubMed

    Mimatsu, Kenji; Oida, Takatsugu; Kawasaki, Atsushi; Kida, Kazutoshi; Fukino, Nobutada; Kuboi, Youichi; Kano, Hisao; Amano, Sadao

    2011-06-01

    A 61-year-old man had been receiving phenytoin(225mg/day)and valproate(600mg/day)for several years as the treatment for seizures. He was diagnosed with advanced gastric cancer,and S-1 plus cisplatin treatment was administered as neoadjuvant chemotherapy because bulky lymph node metastases were found at the time of the initial diagnosis. He complained of weakness of the lower extremities,light -headedness,and trembling of the upper extremities 2 months after the start of concomitant treatment with S-1 plus cisplatin. The serum phenytoin concentration increased to 21. 2mg/mL. Head computed tomography and magnetic resonance imaging did not reveal any intracranial lesion such as brain metastasis. Therefore, we diagnosed phenytoin toxicity due to concomitant use of S-1 and phenytoin,and the dose of phenytoin was then decreased to 150 mg. Although the weakness of the lower extremities improved,light -headedness remained. Phenytoin and valproate treatments were stopped,and he was able to walk 7 days after the termination of therapy. It is important to predict the timing of phenytoin toxicity due to S-1,and therapeutic drug monitoring should be performed in patients receiving S-1 plus cisplatin and phenytoin. PMID:21677496

  1. Cirrhosis and Advanced Fibrosis in Hispanics in Texas: The Dominant Contribution of Central Obesity.

    PubMed

    Jiao, Jingjing; Watt, Gordon P; Lee, MinJae; Rahbar, Mohammad H; Vatcheva, Kristina P; Pan, Jen-Jung; McCormick, Joseph B; Fisher-Hoch, Susan P; Fallon, Michael B; Beretta, Laura

    2016-01-01

    Liver cirrhosis is a leading cause of death in Hispanics and Hispanics who live in South Texas have the highest incidence of liver cancer in the United States. We aimed at determining the prevalence and associated risk factors of cirrhosis in this population. Clinical and demographic variables were extracted for 2466 participants in the community-based Cameron County Hispanic Cohort in South Texas. Aspartate transaminase to Platelet Ratio Index (APRI) was used to predict cirrhosis in Cameron County Hispanic Cohort. The prevalence of cirrhosis using APRI≥2 was 0.94%, which is nearly 4-fold higher than the national prevalence. Using APRI≥1, the overall prevalence of cirrhosis/advanced fibrosis was 3.54%. In both analyses, highest prevalence was observed in males, specifically in the 25-34 age group. Risk factors independently associated with APRI≥2 and APRI≥1 included hepatitis C, diabetes and central obesity with a remarkable population attributable fraction of 52.5% and 65.3% from central obesity, respectively. Excess alcohol consumption was also independently associated with APRI≥2. The presence of patatin-like phospholipase domain-containing-3 gene variants was independently associated with APRI≥1 in participants >50 years old. Males with both central obesity and excess alcohol consumption presented with cirrhosis/advanced fibrosis at a young age. Alarmingly high prevalence of cirrhosis and advanced fibrosis was identified in Hispanics in South Texas, affecting young males in particular. Central obesity was identified as the major risk factor. Public health efforts are urgently needed to increase awareness and diagnosis of advanced liver fibrosis in Hispanics. PMID:26950933

  2. Cirrhosis and Advanced Fibrosis in Hispanics in Texas: The Dominant Contribution of Central Obesity.

    PubMed

    Jiao, Jingjing; Watt, Gordon P; Lee, MinJae; Rahbar, Mohammad H; Vatcheva, Kristina P; Pan, Jen-Jung; McCormick, Joseph B; Fisher-Hoch, Susan P; Fallon, Michael B; Beretta, Laura

    2016-01-01

    Liver cirrhosis is a leading cause of death in Hispanics and Hispanics who live in South Texas have the highest incidence of liver cancer in the United States. We aimed at determining the prevalence and associated risk factors of cirrhosis in this population. Clinical and demographic variables were extracted for 2466 participants in the community-based Cameron County Hispanic Cohort in South Texas. Aspartate transaminase to Platelet Ratio Index (APRI) was used to predict cirrhosis in Cameron County Hispanic Cohort. The prevalence of cirrhosis using APRI≥2 was 0.94%, which is nearly 4-fold higher than the national prevalence. Using APRI≥1, the overall prevalence of cirrhosis/advanced fibrosis was 3.54%. In both analyses, highest prevalence was observed in males, specifically in the 25-34 age group. Risk factors independently associated with APRI≥2 and APRI≥1 included hepatitis C, diabetes and central obesity with a remarkable population attributable fraction of 52.5% and 65.3% from central obesity, respectively. Excess alcohol consumption was also independently associated with APRI≥2. The presence of patatin-like phospholipase domain-containing-3 gene variants was independently associated with APRI≥1 in participants >50 years old. Males with both central obesity and excess alcohol consumption presented with cirrhosis/advanced fibrosis at a young age. Alarmingly high prevalence of cirrhosis and advanced fibrosis was identified in Hispanics in South Texas, affecting young males in particular. Central obesity was identified as the major risk factor. Public health efforts are urgently needed to increase awareness and diagnosis of advanced liver fibrosis in Hispanics.

  3. Locally Advanced Rectal Cancer Patients Receiving Radio-Chemotherapy: A Novel Clinical-Pathologic Score Correlates With Global Outcome

    SciTech Connect

    Berardi, Rossana; Mantello, Giovanna; Scartozzi, Mario; Del Prete, Stefano; Luppi, Gabriele; Martinelli, Roberto; Fumagalli, Marco; Grillo-Ruggieri, Filippo; Bearzi, Italo; Mandolesi, Alessandra; Marmorale, Cristina; Cascinu, Stefano

    2009-12-01

    Purpose: To determine the importance of downstaging of locally advanced rectal cancer after neoadjuvant treatment. Methods and Materials: The study included all consecutive patients with locally advanced rectal cancer who underwent neoadjuvant treatment (chemotherapy and/or radiotherapy) in different Italian centers from June 1996 to December 2003. A novel score was used, calculated as the sum of numbers obtained by giving a negative or positive point, respectively, to each degree of increase or decrease in clinical to pathologic T and N status. Results: A total of 317 patients were eligible for analysis. Neoadjuvant treatments performed were as follows: radiotherapy alone in 75 of 317 patients (23.7%), radiotherapy plus chemotherapy in 242 of 317 patients (76.3%). Worse disease-free survival was observed in patients with a lower score (Score 1 = -3 to +3 vs. Score 2 = +4 to +7; p = 0.04). Conclusions: Our results suggest that a novel score, calculated from preoperative and pathologic tumor and lymph node status, could represent an important parameter to predict outcome in patients receiving neoadjuvant treatment for rectal cancer. The score could be useful to select patients for adjuvant chemotherapy after neoadjuvant treatment and surgery.

  4. Characteristics of Students Receiving Special Education Services in a Central Minnesota School District According to Setting, Classification, and Level of Service.

    ERIC Educational Resources Information Center

    Ittenbach, Richard F.; And Others

    The records of 1,231 preschool, elementary, and secondary students receiving special education services in a central Minnesota school district were evaluated to provide information on differences according to setting, classification, and level of service. Data were analyzed within the context of four broad domains: demographics (age, race, gender,…

  5. Gold shunt for refractory advanced low-tension glaucoma with spared central acuity

    PubMed Central

    Le, Ryan; Gupta, Neeru

    2016-01-01

    The aim of this study is to report a case of gold shunt surgery for uncontrolled, low-tension glaucoma with good central vision, after having a previously failed trabeculectomy and tube shunt surgeries. The patient was receiving maximum medical glaucoma therapy of four different types with intraocular pressure of 17 mm Hg prior to gold shunt surgery. Five years later, intraocular pressure is well controlled in the low teens without the need for ocular medications, and glaucoma is stable following gold shunt surgery. PMID:27051320

  6. Preliminary design of the Carrisa Plains solar central receiver power plant. Volume III, Book 3. Appendices. Part 2

    SciTech Connect

    Lee, S. K.

    1983-12-31

    The auxiliary heat transport systems of the Carrisa Plains Solar Power Plant (CPSPP) comprise facilities which are used to support plant operation and provide plant safety and maintenance. The facilities are the sodium purification system, argon cover gas system, sodium receiving and filling system, sodium-water reaction product receiving system, and safety and maintenance equipment. The functions of the facilities of the auxiliary system are described. Design requirements are established based on plant operating parameters. Descriptions are given on the system which will be adequate to perform the function and satisfy the requirements. Valve and equipment lists are included in the appendix.

  7. Use of Sandia's Central Receiver Test Facility as a high-intensity heat source for testing missile nose-cone (Radome) radar systems

    SciTech Connect

    Porter, D.R.

    1981-09-01

    A series of tests at Sandia's Central Receiver Test Facility in support of the US Navy's SM-2 Blk 2 Radome Improvement Program is described. The CRTF was the source of high-intensity solar radiation for testing onboard radar-tracking systems under heating conditions intended to simulate those that occur in supersonic flight. Also discussed are the hardware used and the software developed at the CRTF.

  8. Preliminary design of the Carrisa Plains solar central receiver power plant. Volume III, Book 3. Appendices, Part 1

    SciTech Connect

    Mouradian, E. M.

    1983-12-31

    Thermal analyses for the preliminary design phase of the Receiver of the Carrizo Plains Solar Power Plant are presented. The sodium reference operating conditions (T/sub in/ = 610/sup 0/F, T/sub out/ = 1050/sup 0/F) have been considered. Included are: Nominal flux distribution on receiver panal, Energy input to tubes, Axial temperature distribution; sodium and tubes, Sodium flow distribution, Sodium pressure drop, orifice calculations, Temperature distribution in tube cut (R-0), Backface structure, and Nonuniform sodium outlet temperature. Transient conditions and panel front face heat losses are not considered. These are to be addressed in a subsequent design phase. Also to be considered later are the design conditions as variations from the nominal reference (operating) condition. An addendum, designated Appendix C, has been included describing panel heat losses, panel temperature distribution, and tube-manifold joint thermal model.

  9. In-situ measurement of concentrated solar flux and distribution at the aperture of a central solar receiver

    NASA Astrophysics Data System (ADS)

    Ferriere, Alain; Volut, Mikael; Perez, Antoine; Volut, Yann

    2016-05-01

    A flux mapping system has been designed, implemented and experimented at the top of the Themis solar tower in France. This system features a moving bar associated to a CCD video camera and a flux gauge mounted onto the bar used as reference measurement for calibration purpose. Images and flux signal are acquired separately. The paper describes the equipment and focus on the data processing to issue the distribution of flux density and concentration at the aperture of the solar receiver. Finally, the solar power entering into the receiver is estimated by integration of flux density. The processing is largely automated in the form of a dedicated software with fast execution. A special attention is paid to the accuracy of the results, to the robustness of the algorithm and to the velocity of the processing.

  10. 41 CFR 304-3.12 - Must I receive advance approval from my agency before I perform travel paid by a non-Federal...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... approval from my agency before I perform travel paid by a non-Federal source to attend a meeting? 304-3.12... agency before I perform travel paid by a non-Federal source to attend a meeting? Yes, you must receive advance approval from your agency before performing travel paid by a non-Federal source to attend...

  11. 41 CFR 304-3.12 - Must I receive advance approval from my agency before I perform travel paid by a non-Federal...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... approval from my agency before I perform travel paid by a non-Federal source to attend a meeting? 304-3.12... agency before I perform travel paid by a non-Federal source to attend a meeting? Yes, you must receive advance approval from your agency before performing travel paid by a non-Federal source to attend...

  12. 41 CFR 302-9.11 - May I receive an advance of funds for transportation and emergency storage of my POV?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... of funds for transportation and emergency storage of my POV? 302-9.11 Section 302-9.11 Public... STORAGE OF PROPERTY 9-ALLOWANCES FOR TRANSPORTATION AND EMERGENCY STORAGE OF A PRIVATELY OWNED VEHICLE General Rules § 302-9.11 May I receive an advance of funds for transportation and emergency storage of...

  13. Learning to bypass the central bottleneck: declining automaticity with advancing age.

    PubMed

    Maquestiaux, François; Laguë-Beauvais, Maude; Ruthruff, Eric; Hartley, Alan; Bherer, Louis

    2010-03-01

    Does advancing age reduce the ability to bypass the central bottleneck through task automatization? To answer this question, the authors asked 12 older adults and 20 young adults to first learn to perform an auditory-vocal task (low vs. high pitch) in 6 single-task sessions. Their dual-task performance was then assessed with a psychological refractory period paradigm, in which the highly practiced auditory-vocal task was presented as Task 2, along with an unpracticed visual-manual Task 1. Converging evidence indicated qualitative differences in dual-task performance with age: Whereas the vast majority of young adults bypassed the bottleneck, at most 1 of the 12 older adults was able to do so. Older adults are either reluctant to bypass the bottleneck (as a matter of strategy) or have lost the ability to automatize task performance. PMID:20230138

  14. Science and Technology to Advance Regional Security in the Middle East and Central Asia

    SciTech Connect

    Tompson, A F B; Richardson, J H; Ragaini, R C; Knapp, R B; Rosenberg, N D; Smith, D K; Ball, D Y

    2002-10-09

    This paper is concerned with the promotion and advancement of regional security in the Middle East and Central Asia through the development of bilateral and multilateral cooperation on targeted scientific and technical projects. It is widely recognized that increasing tensions and instability in many parts of the world emphasize--or reemphasize--a need to seek and promote regional security in these areas. At the Lawrence Livermore National Laboratory (LLNL), a national security research facility operated for the US Department of Energy, we are pursuing an effort to use science and technology as a ''low risk'' means of engagement in regions of strategic importance to the United States. In particular, we are developing collaborations and cooperative projects among (and between) national laboratory scientists in the US and our various counterparts in the countries of interest.

  15. Development of advanced superconducting coil technologies for the National Centralized Tokamak

    NASA Astrophysics Data System (ADS)

    Kizu, K.; Miura, Y. M.; Tsuchiya, K.; Ando, T.; Koizumi, N.; Matsui, K.; Sakasai, A.; Tamai, H.; Matsukawa, M.; Ishida, S.; Okuno, K.

    2005-11-01

    Advanced technologies for fabrication of superconducting coils have been developed for the National Centralized Tokamak which is based on modification of JT-60. One of the technologies developed is the application of the react-and-wind (R&W) method of fabrication of a Nb3Al D-shaped coil. The bending strain of 0.4% due to the R&W method did not affect the critical current characteristics. This finding indicates the possibilities that the manufacturing cost of large size coils can be reduced further by downsizing the heat treatment furnace, and large complicated shape coils can be manufactured by using the Nb3Al conductor. Another technology is an advanced winding technique for the reduction of the ac losses of Nb3Sn coils by loading bending strain on the conductor. It was found that 0.2% bending strain is enough to reduce the ac losses to one-fifth at the virgin state. The newly developed NbTi conductor attained both (i) low ac loss of 116 ms in coupling time constant and (ii) low cost owing to the stainless steel wrap of the sub-cables and Ni plated NbTi strands with 11 µm filaments.

  16. Shrubline but not treeline advance matches climate velocity in montane ecosystems of south-central Alaska.

    PubMed

    Dial, Roman J; Smeltz, T Scott; Sullivan, Patrick F; Rinas, Christina L; Timm, Katriina; Geck, Jason E; Tobin, S Carl; Golden, Trevor S; Berg, Edward C

    2016-05-01

    Tall shrubs and trees are advancing into many tundra and wetland ecosystems but at a rate that often falls short of that predicted due to climate change. For forest, tall shrub, and tundra ecosystems in two pristine mountain ranges of Alaska, we apply a Bayesian, error-propagated calculation of expected elevational rise (climate velocity), observed rise (biotic velocity), and their difference (biotic inertia). We show a sensitive dependence of climate velocity on lapse rate and derive biotic velocity as a rigid elevational shift. Ecosystem presence identified from recent and historic orthophotos ~50 years apart was regressed on elevation. Biotic velocity was estimated as the difference between critical point elevations of recent and historic logistic fits divided by time between imagery. For both mountain ranges, the 95% highest posterior density of climate velocity enclosed the posterior distributions of all biotic velocities. In the Kenai Mountains, mean tall shrub and climate velocities were both 2.8 m y(-1). In the better sampled Chugach Mountains, mean tundra retreat was 1.2 m y(-1) and climate velocity 1.3 m y(-1). In each mountain range, the posterior mode of tall woody vegetation velocity (the complement of tundra) matched climate velocity better than either forest or tall shrub alone, suggesting competitive compensation can be important. Forest velocity was consistently low at 0.1-1.1 m y(-1), indicating treeline is advancing slowly. We hypothesize that the high biotic inertia of forest ecosystems in south-central Alaska may be due to competition with tall shrubs and/or more complex climate controls on the elevational limits of trees than tall shrubs. Among tall shrubs, those that disperse farthest had lowest inertia. Finally, the rapid upward advance of woody vegetation may be contributing to regional declines in Dall's sheep (Ovis dalli), a poorly dispersing alpine specialist herbivore with substantial biotic inertia due to dispersal reluctance.

  17. Shrubline but not treeline advance matches climate velocity in montane ecosystems of south-central Alaska.

    PubMed

    Dial, Roman J; Smeltz, T Scott; Sullivan, Patrick F; Rinas, Christina L; Timm, Katriina; Geck, Jason E; Tobin, S Carl; Golden, Trevor S; Berg, Edward C

    2016-05-01

    Tall shrubs and trees are advancing into many tundra and wetland ecosystems but at a rate that often falls short of that predicted due to climate change. For forest, tall shrub, and tundra ecosystems in two pristine mountain ranges of Alaska, we apply a Bayesian, error-propagated calculation of expected elevational rise (climate velocity), observed rise (biotic velocity), and their difference (biotic inertia). We show a sensitive dependence of climate velocity on lapse rate and derive biotic velocity as a rigid elevational shift. Ecosystem presence identified from recent and historic orthophotos ~50 years apart was regressed on elevation. Biotic velocity was estimated as the difference between critical point elevations of recent and historic logistic fits divided by time between imagery. For both mountain ranges, the 95% highest posterior density of climate velocity enclosed the posterior distributions of all biotic velocities. In the Kenai Mountains, mean tall shrub and climate velocities were both 2.8 m y(-1). In the better sampled Chugach Mountains, mean tundra retreat was 1.2 m y(-1) and climate velocity 1.3 m y(-1). In each mountain range, the posterior mode of tall woody vegetation velocity (the complement of tundra) matched climate velocity better than either forest or tall shrub alone, suggesting competitive compensation can be important. Forest velocity was consistently low at 0.1-1.1 m y(-1), indicating treeline is advancing slowly. We hypothesize that the high biotic inertia of forest ecosystems in south-central Alaska may be due to competition with tall shrubs and/or more complex climate controls on the elevational limits of trees than tall shrubs. Among tall shrubs, those that disperse farthest had lowest inertia. Finally, the rapid upward advance of woody vegetation may be contributing to regional declines in Dall's sheep (Ovis dalli), a poorly dispersing alpine specialist herbivore with substantial biotic inertia due to dispersal reluctance. PMID

  18. 41 CFR 302-9.11 - May I receive an advance of funds for transportation and emergency storage of my POV?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... of funds for transportation and emergency storage of my POV? 302-9.11 Section 302-9.11 Public... General Rules § 302-9.11 May I receive an advance of funds for transportation and emergency storage of my... storage of your POV. Effective Date Note: By FTR Amdt. 2011-01, 76 FR 18342, Apr. 1, 2011, § 302-9.11...

  19. Power conditioning subsystems for photovoltaic central-station power plants - State-of-the-art and advanced technology

    NASA Technical Reports Server (NTRS)

    Bulawka, A.; Krauthamer, S.; Das, R.

    1986-01-01

    An overview is given of the technical and near-term cost requirements that must be met to develop economically viable power conditioning subsystems (PCS) for large-scale, central photovoltaic power stations. Various commercially available PCS hardware suitable for use in today's central photovoltaic power stations are also surveyed. Federal and industrial activities in the research and development of advanced PCSs that will contribute to the attainment of fully competitive, large-scale photovoltaic power stations are reviewed. The status of the DOE central station PCS program is discussed.

  20. [Advances in the etiology, diagnosis and treatment of central precocious puberty].

    PubMed

    Macedo, Delanie B; Cukier, Priscilla; Mendonca, Berenice B; Latronico, Ana Claudia; Brito, Vinicius Nahime

    2014-03-01

    The onset of puberty is first detected as an increase in the amplitude and frequency of pulses of gonadotropin-releasing hormone (GnRH) after a quiescent period during childhood. The reemergence of pulsatile GnRH secretion leads to increases in the secretion of the gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) by the pituitary gland, and the consequent activation of gonadal function. Early activation of the hypothalamic-pituitary-gonadal axis results in gonadotropin-dependent precocious puberty, also known as central precocious puberty (CPP), which is clinically defined by the development of secondary sexual characteristics before the age of 8 years in girls and 9 years in boys. Pubertal timing is influenced by complex interactions among genetic, nutritional, environmental, and socioeconomic factors. CPP is diagnosed on the basis of clinical signs of progressive pubertal development before the age of 8 years in girls and 9 years in boys, pubertal basal and/or GnRH-stimulated LH levels, and advanced bone age. Magnetic resonance imaging of the central nervous system is essential for establishing the CPP form as organic or idiopathic. Depot GnRH-analogues represent the first-line of therapy in CPP. Very recently, the genetic component of CPP was demonstrated by the evidence that the deficiency of the MKRN3 gene, located on long arm of chromosome 15, causes familial CPP in humans. In this current review, clinical and therapeutic aspects of the CPP will be discussed, contributing to adequate diagnosis and criterious approach of this relevant condition of pediatric endocrinology.

  1. 41 CFR 301-31.14 - May I receive a travel advance for transportation and/or subsistence expenses?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-51.200 of this chapter for up to a 30-day period at a time to cover expenses allowable. Your travel... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false May I receive a travel... Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...

  2. 41 CFR 301-31.14 - May I receive a travel advance for transportation and/or subsistence expenses?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-51.200 of this chapter for up to a 30-day period at a time to cover expenses allowable. Your travel... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false May I receive a travel... Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...

  3. 41 CFR 301-31.14 - May I receive a travel advance for transportation and/or subsistence expenses?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-51.200 of this chapter for up to a 30-day period at a time to cover expenses allowable. Your travel... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false May I receive a travel... Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...

  4. 41 CFR 301-31.14 - May I receive a travel advance for transportation and/or subsistence expenses?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-51.200 of this chapter for up to a 30-day period at a time to cover expenses allowable. Your travel... 41 Public Contracts and Property Management 4 2013-07-01 2012-07-01 true May I receive a travel... Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...

  5. Results of molten salt panel and component experiments for solar central receivers: Cold fill, freeze/thaw, thermal cycling and shock, and instrumentation tests

    SciTech Connect

    Pacheco, J.E.; Ralph, M.E.; Chavez, J.M.; Dunkin, S.R.; Rush, E.E.; Ghanbari, C.M.; Matthews, M.W.

    1995-01-01

    Experiments have been conducted with a molten salt loop at Sandia National Laboratories in Albuquerque, NM to resolve issues associated with the operation of the 10MW{sub e} Solar Two Central Receiver Power Plant located near Barstow, CA. The salt loop contained two receiver panels, components such as flanges and a check valve, vortex shedding and ultrasonic flow meters, and an impedance pressure transducer. Tests were conducted on procedures for filling and thawing a panel, and assessing components and instrumentation in a molten salt environment. Four categories of experiments were conducted: (1) cold filling procedures, (2) freeze/thaw procedures, (3) component tests, and (4) instrumentation tests. Cold-panel and -piping fill experiments are described, in which the panels and piping were preheated to temperatures below the salt freezing point prior to initiating flow, to determine the feasibility of cold filling the receiver and piping. The transient thermal response was measured, and heat transfer coefficients and transient stresses were calculated from the data. Freeze/thaw experiments were conducted with the panels, in which the salt was intentionally allowed to freeze in the receiver tubes, then thawed with heliostat beams. Slow thermal cycling tests were conducted to measure both how well various designs of flanges (e.g., tapered flanges or clamp type flanges) hold a seal under thermal conditions typical of nightly shut down, and the practicality of using these flanges on high maintenance components. In addition, the flanges were thermally shocked to simulate cold starting the system. Instrumentation such as vortex shedding and ultrasonic flow meters were tested alongside each other, and compared with flow measurements from calibration tanks in the flow loop.

  6. Stereotactic Radiation Therapy can Safely and Durably Control Sites of Extra-Central Nervous System Oligoprogressive Disease in Anaplastic Lymphoma Kinase-Positive Lung Cancer Patients Receiving Crizotinib

    SciTech Connect

    Gan, Gregory N.; Weickhardt, Andrew J.; Scheier, Benjamin; Doebele, Robert C.; Gaspar, Laurie E.; Kavanagh, Brian D.; Camidge, D. Ross

    2014-03-15

    Purpose: To analyze the durability and toxicity of radiotherapeutic local ablative therapy (LAT) applied to extra-central nervous system (eCNS) disease progression in anaplastic lymphoma kinase-positive non-small cell lung cancer (NSCLC) patients. Methods and Materials: Anaplastic lymphoma kinase-positive NSCLC patients receiving crizotinib and manifesting ≤4 discrete sites of eCNS progression were classified as having oligoprogressive disease (OPD). If subsequent progression met OPD criteria, additional courses of LAT were considered. Crizotinib was continued until eCNS progression was beyond OPD criteria or otherwise not suitable for further LAT. Results: Of 38 patients, 33 progressed while taking crizotinib. Of these, 14 had eCNS progression meeting OPD criteria suitable for radiotherapeutic LAT. Patients with eCNS OPD received 1-3 courses of LAT with radiation therapy. The 6- and 12-month actuarial local lesion control rates with radiation therapy were 100% and 86%, respectively. The 12-month local lesion control rate with single-fraction equivalent dose >25 Gy versus ≤25 Gy was 100% versus 60% (P=.01). No acute or late grade >2 radiation therapy-related toxicities were observed. Median overall time taking crizotinib among those treated with LAT versus those who progressed but were not suitable for LAT was 28 versus 10.1 months, respectively. Patients continuing to take crizotinib for >12 months versus ≤12 months had a 2-year overall survival rate of 72% versus 12%, respectively (P<.0001). Conclusions: Local ablative therapy safely and durably eradicated sites of individual lesion progression in anaplastic lymphoma kinase-positive NSCLC patients receiving crizotinib. A dose–response relationship for local lesion control was observed. The suppression of OPD by LAT in patients taking crizotinib allowed an extended duration of exposure to crizotinib, which was associated with longer overall survival.

  7. Fluidized-bed technology enabling the integration of high temperature solar receiver CSP systems with steam and advanced power cycles

    SciTech Connect

    Sakadjian, B.; Hu, S.; Maryamchik, M.; Flynn, T.; Santelmann, K.; Ma, Z.

    2015-06-05

    Solar Particle Receivers (SPR) are under development to drive concentrating solar plants (CSP) towards higher operating temperatures to support higher efficiency power conversion cycles. The novel high temperature SPR-based CSP system uses solid particles as the heat transfer medium (HTM) in place of the more conventional fluids such as molten salt or steam used in current state-of-the-art CSP plants. The solar particle receiver (SPR) is designed to heat the HTM to temperatures of 800 °C or higher which is well above the operating temperatures of nitrate-based molten salt thermal energy storage (TES) systems. The solid particles also help overcome some of the other challenges associated with molten salt-based systems such as freezing, instability and degradation. The higher operating temperatures and use of low cost HTM and higher efficiency power cycles are geared towards reducing costs associated with CSP systems. This paper describes the SPR-based CSP system with a focus on the fluidized-bed (FB) heat exchanger and its integration with various power cycles. Furthermore, the SPR technology provides a potential pathway to achieving the levelized cost of electricity (LCOE) target of $0.06/kWh that has been set by the U.S. Department of Energy's SunShot initiative.

  8. Fluidized-bed technology enabling the integration of high temperature solar receiver CSP systems with steam and advanced power cycles

    DOE PAGES

    Sakadjian, B.; Hu, S.; Maryamchik, M.; Flynn, T.; Santelmann, K.; Ma, Z.

    2015-06-05

    Solar Particle Receivers (SPR) are under development to drive concentrating solar plants (CSP) towards higher operating temperatures to support higher efficiency power conversion cycles. The novel high temperature SPR-based CSP system uses solid particles as the heat transfer medium (HTM) in place of the more conventional fluids such as molten salt or steam used in current state-of-the-art CSP plants. The solar particle receiver (SPR) is designed to heat the HTM to temperatures of 800 °C or higher which is well above the operating temperatures of nitrate-based molten salt thermal energy storage (TES) systems. The solid particles also help overcome somemore » of the other challenges associated with molten salt-based systems such as freezing, instability and degradation. The higher operating temperatures and use of low cost HTM and higher efficiency power cycles are geared towards reducing costs associated with CSP systems. This paper describes the SPR-based CSP system with a focus on the fluidized-bed (FB) heat exchanger and its integration with various power cycles. Furthermore, the SPR technology provides a potential pathway to achieving the levelized cost of electricity (LCOE) target of $0.06/kWh that has been set by the U.S. Department of Energy's SunShot initiative.« less

  9. Approaches for delineating landslide hazard areas using receiver operating characteristic in an advanced calibrating precision soil erosion model

    NASA Astrophysics Data System (ADS)

    Ghazvinei, P. T.; Zandi, J.; Ariffin, J.; Hashim, R. B.; Motamedi, S.; Aghamohammadi, N.; Moghaddam, D. A.

    2015-10-01

    Soil erosion is undesirable natural event that causes land degradation and desertification. Identify the erosion-prone areas is a major component of preventive measures. Recent landslide damages at different regions lead us to develop a model of the erosion susceptibility map using empirical method (RUSLE). A landslide-location map was established by interpreting satellite image. Field observation data was used to validate the intensity of soil erosion. Further, a correlation analysis was conducted to investigate the "Receiver Operating Characteristic" and frequency ratio. Results showed a satisfactory correlation between the prepared RUSLE-based soil erosion map and actual landslide distribution. The proposed model can effectively predict the landslide events in soil-erosion area. Such a reliable predictive model is an effective management facility for the regional landslide forecasting system.

  10. Results of a phase I dose escalation study of eltrombopag in patients with advanced soft tissue sarcoma receiving doxorubicin and ifosfamide

    PubMed Central

    2013-01-01

    Background The objective of this Phase I dose escalation study was to explore the safety and tolerability of eltrombopag, an oral, nonpeptide, thrombopoietin receptor agonist, in patients with advanced soft tissue sarcoma (STS) and thrombocytopenia due to treatment with doxorubicin and ifosfamide (AI) combination chemotherapy. Methods Patients aged 18 or older with histologically confirmed, locally advanced or metastatic STS were treated with 1 cycle of AI followed by AI with eltrombopag starting at Cycle 2, using 2 different dosing schedules. The study design included an eltrombopag dose escalation phase starting at 75 mg daily to determine the optimal biological dose (OBD). Results Eighteen patients were enrolled and 15 received at least 1 dose of chemotherapy; 3 patients withdrew prior to receiving eltrombopag. Seven, 4, and 1 patients received 75 mg, 100 mg, and 150 mg eltrombopag daily, respectively. No dose-limiting toxicities were reported. Due to slow recruitment, the study was closed prior to identifying an OBD. The most common hematologic adverse events (AEs) were thrombocytopenia (80%), neutropenia (73%), and anemia (67%). The most common nonhematologic AEs were fatigue (53%), alanine aminotransferase increased, constipation, and nausea (47% each). Eleven of 12 patients who received eltrombopag completed at least 2 chemotherapy cycles; all had increased platelet counts on Day 1 of Cycle 2 (cycle with eltrombopag) compared to Day 1 of Cycle 1 (cycle without eltrombopag). Conclusions Although data are limited, safety data were consistent with the known toxicities of AI combination chemotherapy or the side effect profile of eltrombopag seen in other studies. Available data suggest a potential pre- and post-chemotherapy dosing scheme for eltrombopag when administered with AI chemotherapy, and support further investigation of eltrombopag treatment in patients with chemotherapy-induced thrombocytopenia. PMID:23497336

  11. Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab.

    PubMed

    Price, Timothy J; Hardingham, Jennifer E; Lee, Chee K; Townsend, Amanda R; Wrin, Joseph W; Wilson, Kate; Weickhardt, Andrew; Simes, Robert J; Murone, Carmel; Tebbutt, Niall C

    2013-06-01

    Loss of phosphatase and tensin homologue (PTEN) expression may be prognostic in colorectal cancer (CRC) and may have a correlation with vascular endothelial growth factor (VEGF) expression via hypoxia-inducible factor 1 (HIF-1) alpha, and the PI3K/mTOR pathways. We therefore have explored the prognostic association of PTEN loss and the potential that PTEN loss may be predictive of outcome with bevacizumab. Patients enrolled in the AGITG MAX trial, a randomized Phase III trial of capecitabine (C) +/- bevacizumab (B) (+/- mitomycin C [M]) with available tissues were analyzed for PTEN expression (loss vs. no loss) as assessed using a Taqman® copy number assay (CNA). Of the original 471 patients enrolled, tissues from 302 (64.1%) patients were analyzed. PTEN loss was observed in 38.7% of patients. There was no relationship between PTEN loss and KRAS or BRAF mutation. PTEN status was not prognostic for progression-free survival (PFS) or overall survival (OS) in multivariate analyses adjusting for other baseline factors; loss versus no loss PFS hazard ratio (HR) 0.9 (0.7-1.16), OS HR 1.04 (0.79-1.38). PTEN was not prognostic when assessed by KRAS and BRAF status. By using the comparison of C versus CB+CBM, PTEN status was not significantly predictive of the effectiveness of B for PFS or OS. PTEN status was not prognostic for survival in advanced colorectal cancer, irrespective of KRAS or BRAF status. PTEN status did not significantly predict different benefit with bevacizumb therapy.

  12. Comparison of contaminants of emerging concern removal, discharge, and water quality hazards among centralized and on-site wastewater treatment system effluents receiving common wastewater influent.

    PubMed

    Du, Bowen; Price, Amy E; Scott, W Casan; Kristofco, Lauren A; Ramirez, Alejandro J; Chambliss, C Kevin; Yelderman, Joe C; Brooks, Bryan W

    2014-01-01

    A comparative understanding of effluent quality of decentralized on-site wastewater treatment systems, particularly for contaminants of emerging concern (CECs), remains less understood than effluent quality from centralized municipal wastewater treatment plants. Using a novel experimental facility with common influent wastewater, effluent water quality from a decentralized advanced aerobic treatment system (ATS) and a typical septic treatment system (STS) coupled to a subsurface flow constructed wetland (WET) were compared to effluent from a centralized municipal treatment plant (MTP). The STS did not include soil treatment, which may represent a system not functioning properly. Occurrence and discharge of a range of CECs were examined using isotope dilution liquid chromatography-tandem mass spectrometry during fall and winter seasons. Conventional parameters, including total suspended solids, carbonaceous biochemical oxygen demand and nutrients were also evaluated from each treatment system. Water quality of these effluents was further examined using a therapeutic hazard modeling approach. Of 19 CECs targeted for study, the benzodiazepine pharmaceutical diazepam was the only CEC not detected in all wastewater influent and effluent samples over two sampling seasons. Diphenhydramine, codeine, diltiazem, atenolol, and diclofenac exhibited significant (p<0.05) seasonal differences in wastewater influent concentrations. Removal of CECs by these wastewater treatment systems was generally not influenced by season. However, significant differences (p<0.05) for a range of water quality indicators were observed among the various treatment technologies. For example, removal of most CECs by ATS was generally comparable to MTP. Lowest removal of most CECs was observed for STS; however, removal was improved when coupling the STS to a WET. Across the treatment systems examined, the majority of pharmaceuticals observed in on-site and municipal effluent discharges were predicted

  13. Impact of biliary stent-related events in patients diagnosed with advanced pancreatobiliary tumours receiving palliative chemotherapy

    PubMed Central

    Lamarca, Angela; Rigby, Christina; McNamara, Mairéad G; Hubner, Richard A; Valle, Juan W

    2016-01-01

    AIM: To determine the impact (morbidity/mortality) of biliary stent-related events (SRE) (cholangitis or stent obstruction) in chemotherapy-treated pancreatico-biliary patients. METHODS: All consecutive patients with advanced pancreatobiliary cancer and a biliary stent in-situ prior to starting palliative chemotherapy were identified retrospectively from local electronic case-note records (Jan 13 to Jan 15). The primary end-point was SRE rate and the time-to-SRE (defined as time from first stenting before chemotherapy to date of SRE). Progression-free survival and overall survival were measured from the time of starting chemotherapy. Kaplan-Meier, Cox and Fine-Gray regression (univariate and multivariable) analyses were employed, as appropriate. For the analysis of time-to-SRE, death was considered as a competing event. RESULTS: Ninety-six out of 693 screened patients were eligible; 89% had a metal stent (the remainder were plastic). The median time of follow-up was 9.6 mo (range 2.2 to 26.4). Forty-one patients (43%) developed a SRE during follow-up [cholangitis (39%), stent obstruction (29%), both (32%)]. There were no significant differences in baseline characteristics between the SRE group and no-SRE groups. Recorded SRE-consequences were: none (37%), chemotherapy delay (24%), discontinuation (17%) and death (22%). The median time-to-SRE was 4.4 mo (95%CI: 3.6-5.5). Patients with severe comorbidities (P < 0.001) and patients with ≥ 2 baseline stents/biliary procedures [HR = 2.3 (95%CI: 1.2-4.44), P = 0.010] had a shorter time-to-SRE on multivariable analysis. Stage was an independent prognostic factor for overall survival (P = 0.029) in the multivariable analysis adjusted for primary tumour site, performance status and development of SRE (SRE group vs no-SRE group). CONCLUSION: SREs are common and impact on patient’s morbidity. Our results highlight the need for prospective studies exploring the role of prophylactic strategies to prevent/delay SREs. PMID

  14. Crustal structure of Northern Latium (central Italy) from receiver functions analysis: New evidences of a post-collisional back-arc margin evolution

    NASA Astrophysics Data System (ADS)

    Buttinelli, Mauro; Chiarabba, Claudio; Anselmi, Mario; Bianchi, Irene; De Rita, Donatella; Quattrocchi, Fedora

    2014-05-01

    The crustal velocity structure in a region of central Apennines of Italy at the hinge between the highly stretched portion of the Monte Argentario promontory and the magmatic province of the Tolfa Domes Complex (Northern Latium) is discussed in this study. S-wave velocities at depth have been constrained by the modeling of P-wave receiver functions (RF) from both temporary and permanent broadband seismic stations. The computer 3D Vs models show a thin crust (19-25 km) made of a shallow and thin sedimentary cover, a very high velocity and anisotropic layer related to a metamorphic basement, and a low Vs anisotropic layer in the middle-lower crust above a shallow Moho discontinuity modeled at about 20 km depth. The volcano-tectonic evolution of this portion of Tyrrhenian back-arc margin has been strongly influenced by its peculiar crustal architecture. The low-Vs layer acted as a shear zone in the middle-lower crust during the Tyrrhenian extension, also helping the development of Plio-Quaternary magmatism. Our findings potentially give new constraints on the evolution of the area and to the general comprehension of back-arc development in collisional regions.

  15. Ceramic high temperature receiver design and tests

    NASA Technical Reports Server (NTRS)

    Davis, S. B.

    1982-01-01

    The High Temperature Solar Thermal Receiver, which was tested a Edwards AFB, CA during the winter of 1980-1981, evolved from technologies developed over a five year period of work. This receiver was tested at the Army Solar Furnace at White Sands, NM in 1976. The receiver, was tested successfully at 1768 deg F and showed thermal efficiencies of 85%. The results were sufficiently promising to lead ERDA to fund our development and test of a 250 kW receiver to measure the efficiency of an open cavity receiver atop a central tower of a heliostat field. This receiver was required to be design scalable to 10, 50, and 100 MW-electric sizes to show applicability to central power tower receivers. That receiver employed rectagular silicon carbide panels and vertical stanchions to achieve scalability. The construction was shown to be fully scalable; and the receiver was operated at temperatures up to 2000 deg F to achieve the performance goals of the experiment during tests at the GIT advanced components test facility during the fall of 1978.

  16. Ceramic high temperature receiver design and tests

    SciTech Connect

    Davis, S.B.

    1982-07-01

    The High Temperature Solar Thermal Receiver, which was tested a Edwards AFB, CA during the winter of 1980-1981, evolved from technologies developed over a five year period of work. This receiver was tested at the Army Solar Furnace at White Sands, NM in 1976. The receiver, was tested successfully at 1768 deg F and showed thermal efficiencies of 85%. The results were sufficiently promising to lead ERDA to fund our development and test of a 250 kW receiver to measure the efficiency of an open cavity receiver atop a central tower of a heliostat field. This receiver was required to be design scalable to 10, 50, and 100 MW-electric sizes to show applicability to central power tower receivers. That receiver employed rectangular silicon carbide panels and vertical stanchions to achieve scalability. The construction was shown to be fully scalable, and the receiver was operated at temperatures up to 2000 deg F to achieve the performance goals of the experiment during tests at the GIT advanced components test facility during the fall of 1978.

  17. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Engineering Test Report: Radiated Emissions and SARR, SARP, DCS Receivers, Link Frequencies EMI Sensitive Band Test Results, AMSU-A2, S/N 108, 08

    NASA Technical Reports Server (NTRS)

    Valdez, A.

    2000-01-01

    This is the Engineering Test Report, Radiated Emissions and SARR, SARP, DCS Receivers, Link Frequencies EMI Sensitive Band Test Results, AMSU-A2, S/N 108, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A).

  18. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Engineering Test Report: Radiated Emissions and SARR, SARP, DCS Receivers, Link Frequencies EMI Sensitive Band Test Results, AMSU-A1, S/N 109

    NASA Technical Reports Server (NTRS)

    Valdez, A.

    2000-01-01

    This is the Engineering Test Report, Radiated Emissions and SARR, SARP, DCS Receivers, Link Frequencies EMI Sensitive Band Test Results, AMSU-A1, S/N 109, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A).

  19. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Engineering Test Report: Radiated Emissions and SARR, SARP, DCS Receivers, Link Frequencies EMI Sensitive Band Test Results, AMSU-A1, S/N 108 2

    NASA Technical Reports Server (NTRS)

    Valdez, A.

    2000-01-01

    This is the Engineering Test Report, Radiated Emissions and SARR, SARP, DCS Receivers, Link Frequencies EMI Sensitive Band Test Results, AMSU-A1 SIN 108, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A).

  20. Health Care Outcomes and Advance Care Planning in Older Adults Who Receive Home-Based Palliative Care: A Pilot Cohort Study

    PubMed Central

    Thorsteinsdottir, Bjorg; Cha, Stephen S.; Hanson, Gregory J.; Peterson, Stephanie M.; Rahman, Parvez A.; Naessens, James M.; Takahashi, Paul Y.

    2015-01-01

    Abstract Background: Approximately 20% of seniors live with five or more chronic medical illnesses. Terminal stages of their lives are often characterized by repeated burdensome hospitalizations and advance care directives are insufficiently addressed. This study reports on the preliminary results of a Palliative Care Homebound Program (PCHP) at the Mayo Clinic in Rochester, Minnesota to service these vulnerable populations. Objective: The study objective was to evaluate inpatient hospital utilization and the adequacy of advance care planning in patients who receive home-based palliative care. Methods: This is a retrospective pilot cohort study of patients enrolled in the PCHP between September 2012 and March 2013. Two control patients were matched to each intervention patient by propensity scoring methods that factor in risk and prognosis. Primary outcomes were six-month hospital utilization including ER visits. Secondary outcomes evaluated advance care directive completion and overall mortality. Results: Patients enrolled in the PCHP group (n=54) were matched to 108 controls with an average age of 87 years. Ninety-two percent of controls and 33% of PCHP patients were admitted to the hospital at least once. The average number of hospital admissions was 1.36 per patient for controls versus 0.35 in the PCHP (p<0.001). Total hospital days were reduced by 5.13 days. There was no difference between rates of ER visits. Advanced care directive were completed more often in the intervention group (98%) as compared to controls (31%), with p<0.001. Goals of care discussions were held at least once for all patients in the PCHP group, compared to 41% in the controls. PMID:25375663

  1. Elevated Neutrophil-to-Lymphocyte Ratio Predicts Intermediate-Term Outcomes in Patients Who Have Advanced Chronic Kidney Disease with Peripheral Artery Disease Receiving Percutaneous Transluminal Angioplasty

    PubMed Central

    Chen, I-Chih; Yu, Chao-Chin; Wu, Yi-Hsuan; Chao, Ting-Hsing

    2016-01-01

    Background Inflammation plays an important role in the pathogenesis of cardiovascular disease in patients with advanced chronic kidney disease (CKD). Neutrophil-to-lymphocyte ratio (NLR), an inflammatory biomarker, has not been evaluated in patients who have advanced CKD with peripheral artery disease (PAD) undergoing percutaneous transluminal angioplasty (PTA), especially in Taiwan. Methods We retrospectively evaluated 148 advanced CKD (creatinine clearance rate ≤ 30 mL/min/1.73 m2) identified from a prospective registry in our hospital (303 PTA cases in total). Kaplan-Meier analysis with log-rank test was used to study event-free survival, and all univariables (p value < 0.1) were put into multivariate Cox regression analysis. Results During the mean follow-up time of 8.6 ± 7.8 months, 35.1% of the cases achieved primary composite endpoint (all-cause mortality or major amputation), 25.5% underwent death from any cause, and 14.9% underwent major or minor amputation. Rutherford grade 6, either NLR or NLR ≥ 3.76, and a history of hypertension had a positively prognostic impact on the occurrence of primary composite endpoint, whereas higher albumin level (≥ 3.0 mg/dL) and technical success had a significantly protective effect. History of hypertension, either NLR or NLR ≥ 3.76, and age were associated with all-cause mortality. In addition, Rutherford 6, higher albumin level (≥ 3.0 mg/dL), technical success, NLR, and age could predict the occurrence of major amputation. Conclusions NLR, but not C-reactive protein or platelet-lymphocyte ratio, is an important prognostic predictor of all major clinical outcomes in patients with advanced CKD and PAD receiving PTA. Further studies are warranted to establish a better strategy and healthcare program in this clinical setting. PMID:27713601

  2. Estimating central blood pressure in the extreme vascular phenotype of advanced kidney disease.

    PubMed

    Boutouyrie, Pierre; London, Gérard M; Sharman, James E

    2016-10-01

    Carlsen et al. demonstrated that the estimation of central blood pressure from peripheral tonometry does not work properly in patients with chronic kidney disease. We explore here the implications of this finding, first by considering the technical conditions for validating central BP monitors, then by discussing the possible causes for discrepancies between chronic kidney disease patients and usual study populations. Lastly, we review the merits and limits of the work by Carlsen et al. PMID:27633868

  3. Advances in tunneled central venous catheters for dialysis: design and performance.

    PubMed

    Ash, Stephen R

    2008-01-01

    Over 70% of patients initiating chronic hemodialysis in the United States have a tunneled central venous catheter (CVC) for dialysis as their first blood access device. Tunneled CVC have requirements that are unparalleled by other access devices: high blood flow rates at moderate pressure drops without obstruction, minimal trauma to the vein, resistance to occlusion by fibrous sheathing, prevention of infection, avoidance of clotting, biocompatibility, avoidance of lumen collapse and kinking and breaks, resistance to antiseptic agents, placement with minimal trauma, and radiopaque appearance on X-ray. This publication reviews the numerous designs for tunneled CVC and evaluates the advantages and disadvantages of each design. A catheter that self-centers in the superior vena cava (Centros) is described, along with early clinical results. Current challenges and future directions for tunneled CVC for dialysis are discussed, included means to diminish catheter-related infections, catheter tip clotting, fibrous sheathing, central venous stenosis, and external component bulk. PMID:19000125

  4. Recent advances in central cardiovascular control: sex, ROS, gas and inflammation

    PubMed Central

    Smith, Pauline M.; Ferguson, Alastair V.

    2016-01-01

    The central nervous system (CNS) in concert with the heart and vasculature is essential to maintaining cardiovascular (CV) homeostasis. In recent years, our understanding of CNS control of blood pressure regulation (and dysregulation leading to hypertension) has evolved substantially to include (i) the actions of signaling molecules that are not classically viewed as CV signaling molecules, some of which exert effects at CNS targets in a non-traditional manner, and (ii) CNS locations not traditionally viewed as central autonomic cardiovascular centers. This review summarizes recent work implicating immune signals and reproductive hormones, as well as gasotransmitters and reactive oxygen species in the pathogenesis of hypertension at traditional CV control centers. Additionally, recent work implicating non-conventional CNS structures in CV regulation is discussed. PMID:27092251

  5. Planned FDG PET-CT Scan in Follow-Up Detects Disease Progression in Patients With Locally Advanced NSCLC Receiving Curative Chemoradiotherapy Earlier Than Standard CT

    PubMed Central

    Pan, Yi; Brink, Carsten; Schytte, Tine; Petersen, Henrik; Wu, Yi-long; Hansen, Olfred

    2015-01-01

    Abstract The role of positron emission tomography-computed tomography (PET-CT) in surveillance of patients with nonsmall cell lung cancer (NSCLC) treated with curatively intended chemoradiotherapy remains controversial. However, conventional chest X-ray and computed tomography (CT) are of limited value in discriminating postradiotherapy changes from tumor relapse. The aim of this study was to evaluate the clinical value of PET-CT scan in the follow-up for patients with locally advanced (LA) NSCLC receiving concomitant chemoradiotherapy (CCRT). Between 2009 and 2013, eligible patients with stages IIB–IIIB NSCLC were enrolled in the clinical trial NARLAL and treated in Odense University Hospital (OUH). All patients had a PET-CT scan scheduled 9 months (PET-CT9) after the start of the radiation treatment in addition to standard follow-up (group A). Patients who presented with same clinical stage of NSCLC and received similar treatment, but outside protocol in OUH during this period were selected as control group (group B). Patients in group B were followed in a conventional way without PET-CT9. All patients were treated with induction chemotherapy followed by CCRT. Group A included 37 and group B 55 patients. The median follow-up was 16 months. Sixty-six (72%) patients were diagnosed with progression after treatment. At the time of tumor progression, patients in group A had better performance status (PS) than those in group B (P = 0.02). Because of death (2 patients), poor PS (3) or retreatment of relapse (9), only 23 patients had PET-CT9 in group A. Eleven (48%) patients were firstly diagnosed with progression by PET-CT9 without any clinical symptoms of progression. The median progression-free survival (PFS) was 8.8 months in group A and 12.5 months in group B (P = 0.04). Hazard function PFS showed that patients in group A had higher risk of relapse than in group B. Additional FDG PET-CT scan at 9 months in surveillance increases probability of early

  6. High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy

    PubMed Central

    Gota, Vikram; Kavathiya, Krunal; Doshi, Kartik; Gurjar, Murari; Damodaran, Solai E; Noronha, Vanita; Joshi, Amit; Prabhash, Kumar

    2014-01-01

    Background Pemetrexed-platinum doublet therapy is a standard treatment for stage IIIb/IV nonsquamous non small cell lung cancer (NSCLC). While the regimen is associated with several grade ≥3 toxicities, hyponatremia is not a commonly reported adverse effect. Here we report an unusually high incidence of grade ≥3 hyponatremia in Indian patients receiving pemetrexed-platinum doublet, and the pharmacological basis for this phenomenon. Methods Forty-six patients with advanced NSCLC were enrolled for a bioequivalence study of two pemetrexed formulations. All patients received the pemetrexed-platinum doublet for six cycles followed by single-agent pemetrexed maintenance until progression. Pharmacokinetic blood samples were collected at predefined time points during the first cycle and the concentration-time profile of pemetrexed was investigated by noncompartmental analysis. Hyponatremic episodes were investigated with serum electrolytes, serum osmolality, urinary sodium, and urine osmolality. Results Sixteen of 46 patients (35%) had at least one episode of grade ≥3 hyponatremia. Twenty-four episodes of grade ≥3 hyponatremia were observed in 200 cycles of doublet chemotherapy. Plasma exposure to pemetrexed was significantly higher in patients with high-grade hyponatremia than in those with low-grade or no hyponatremia (P=0.063 and P=0.001, respectively). Pemetrexed clearance in high-grade hyponatremia was quite low compared with normal and low-grade hyponatremia (P=0.001 and P=0.055, respectively). Median pemetrexed exposure in this cohort was much higher than that reported in the literature from Western studies. Conclusion Higher exposure to pemetrexed is associated with grade ≥3 hyponatremia. The pharmacogenetic basis for higher exposure to pemetrexed in Indian patients needs further investigation. PMID:24940080

  7. Baseline Metabolic Tumor Volume and Total Lesion Glycolysis Are Associated With Survival Outcomes in Patients With Locally Advanced Pancreatic Cancer Receiving Stereotactic Body Radiation Therapy

    SciTech Connect

    Dholakia, Avani S.; Chaudhry, Muhammad; Leal, Jeffrey P.; Chang, Daniel T.; Raman, Siva P.; Hacker-Prietz, Amy; Su, Zheng; Pai, Jonathan; Oteiza, Katharine E.; Griffith, Mary E.; Wahl, Richard L.; Tryggestad, Erik; Pawlik, Timothy; Laheru, Daniel A.; Wolfgang, Christopher L.; Koong, Albert C.; and others

    2014-07-01

    Purpose: Although previous studies have demonstrated the prognostic value of positron emission tomography (PET) parameters in other malignancies, the role of PET in pancreatic cancer has yet to be well established. We analyzed the prognostic utility of PET for patients with locally advanced pancreatic cancer (LAPC) undergoing fractionated stereotactic body radiation therapy (SBRT). Materials and Methods: Thirty-two patients with LAPC in a prospective clinical trial received up to 3 doses of gemcitabine, followed by 33 Gy in 5 fractions of 6.6 Gy, using SBRT. All patients received a baseline PET scan prior to SBRT (pre-SBRT PET). Metabolic tumor volume (MTV), total lesion glycolysis (TLG), and maximum and peak standardized uptake values (SUV{sub max} and SUV{sub peak}) on pre-SBRT PET scans were calculated using custom-designed software. Disease was measured at a threshold based on the liver SUV, using the equation Liver{sub mean} + [2 × Liver{sub sd}]. Median values of PET parameters were used as cutoffs when assessing their prognostic potential through Cox regression analyses. Results: Of the 32 patients, the majority were male (n=19, 59%), 65 years or older (n=21, 66%), and had tumors located in the pancreatic head (n=27, 84%). Twenty-seven patients (84%) received induction gemcitabine prior to SBRT. Median overall survival for the entire cohort was 18.8 months (95% confidence interval [CI], 15.7-22.0). An MTV of 26.8 cm{sup 3} or greater (hazard ratio [HR] 4.46, 95% CI 1.64-5.88, P<.003) and TLG of 70.9 or greater (HR 3.08, 95% CI 1.18-8.02, P<.021) on pre-SBRT PET scan were associated with inferior overall survival on univariate analysis. Both pre-SBRT MTV (HR 5.13, 95% CI 1.19-22.21, P=.029) and TLG (HR 3.34, 95% CI 1.07-10.48, P=.038) remained independently associated with overall survival in separate multivariate analyses. Conclusions: Pre-SBRT MTV and TLG are potential predictive factors for overall survival in patients with LAPC and may assist in

  8. Preliminary design of a solar central receiver for a site-specific repowering application (Saguaro Power Plant). Volume III. Specifications. Final report, October 1982-September 1983

    SciTech Connect

    Weber, E.R.

    1983-09-01

    This volume on specifications for the Saguaro Power Plant includes the following: subsystem interface definition document; solar collector subsystem specification; receiver specification; thermal energy storage specification; solar steam generator specification; and master control system specification.

  9. Anisotropic feature inferred from receiver functions and S-wave splitting in and around the high strain rate zone, central Japan

    NASA Astrophysics Data System (ADS)

    Shiomi, K.; Takeda, T.; Sekiguchi, S.

    2012-12-01

    By the recent dense GPS observation, the high strain rate zone (HSRZ) crossing the central Japan was discovered. In the HSRZ, E-W compressive stress field is observed, and large earthquakes with M>6 are frequently occurred. In this study, we try to reveal depth-dependent anisotropic feature in this region by using teleseismic receiver functions (RFs) and S-wave splitting information. As a target, we select NIED Hi-net stations N.TGWH and N.TSTH, which are located inside and outside of the HSRZ respectively. For RF analysis, we choose M>5.5 teleseismic events from October 2000 to November 2011. Low-pass filters with fc = 1 and 2 Hz are applied to estimate RFs. In the radial RFs, we find clear positive phase arrivals at 4 to 4.5 s in delay time for both stations. Since this time delay corresponds to 35 km-depth velocity discontinuity existence, these phases may be the converted phases generated at the Moho discontinuity. Seeing the back-azimuth paste-ups of the transverse RFs, we can find polarity changes of later phases at 4 to 4.5 s in delay time at the N.TSTH station. This polarity change occurs for direction of N0E (north), N180E (south), and N270E (west). Although we have no data in N90E (east) direction, this feature implies that anisotropic rocks may exist around the Moho. In order to check this feature, we consider 6-layered subsurface model and compare synthetic RFs with the observation. The first three layers are for thick sediments and upper crust including a dipping velocity interface. The fourth, fifth and sixth layer corresponds to the mid crust, lower crust and uppermost mantle, respectively. The best model infers that the mid- and lower-crust beneath the N.TSTH station should have strong anisotropy whose fast axis directs to the N-S, though the fast axis in the uppermost mantle seems to show E-W direction. Moreover, to explain the observation, the symmetric axes in the lower crust and the uppermost mantle should be dipping about 20 degrees. To check

  10. Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

    PubMed Central

    Shi, Ligen; Wang, Yan; Zhang, Jianmin

    2016-01-01

    Inflammasomes are multiprotein complexes that trigger the activation of caspases-1 and subsequently the maturation of proinflammatory cytokines interleukin-1β and interleukin-18. These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases. Here, we review recently described mechanisms that are involved in the activation and regulation of NLRP3 inflammasome. In addition, we summarize the recent researches on the role of NLRP3 inflammasome in central nervous system (CNS) diseases, including traumatic brain injury, ischemic stroke and hemorrhagic stroke, brain tumor, neurodegenerative diseases, and other CNS diseases. In conclusion, the NLRP3 inflammasome may be a promising therapeutic target for these CNS diseases.

  11. Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders.

    PubMed

    Zhou, Keren; Shi, Ligen; Wang, Yan; Chen, Sheng; Zhang, Jianmin

    2016-01-01

    Inflammasomes are multiprotein complexes that trigger the activation of caspases-1 and subsequently the maturation of proinflammatory cytokines interleukin-1β and interleukin-18. These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases. Here, we review recently described mechanisms that are involved in the activation and regulation of NLRP3 inflammasome. In addition, we summarize the recent researches on the role of NLRP3 inflammasome in central nervous system (CNS) diseases, including traumatic brain injury, ischemic stroke and hemorrhagic stroke, brain tumor, neurodegenerative diseases, and other CNS diseases. In conclusion, the NLRP3 inflammasome may be a promising therapeutic target for these CNS diseases. PMID:27652274

  12. Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

    PubMed Central

    Shi, Ligen; Wang, Yan; Zhang, Jianmin

    2016-01-01

    Inflammasomes are multiprotein complexes that trigger the activation of caspases-1 and subsequently the maturation of proinflammatory cytokines interleukin-1β and interleukin-18. These cytokines play a critical role in mediating inflammation and innate immunity response. Among various inflammasome complexes, the NLRP3 inflammasome is the best characterized, which has been demonstrated as a crucial role in various diseases. Here, we review recently described mechanisms that are involved in the activation and regulation of NLRP3 inflammasome. In addition, we summarize the recent researches on the role of NLRP3 inflammasome in central nervous system (CNS) diseases, including traumatic brain injury, ischemic stroke and hemorrhagic stroke, brain tumor, neurodegenerative diseases, and other CNS diseases. In conclusion, the NLRP3 inflammasome may be a promising therapeutic target for these CNS diseases. PMID:27652274

  13. A final report on the Phase 1 testing of a molten-salt cavity receiver

    SciTech Connect

    Chavez, J M; Smith, D C

    1992-05-01

    This report describes the design, construction, and testing of a solar central receiver using molten nitrate salt as a heat exchange fluid. Design studies for large commercial plants (30--100 MWe) have shown molten salt to be an excellent fluid for solar thermal plants as it allows for efficient thermal storage. Plant design studies concluded that an advanced receiver test was required to address uncertainties not covered in prior receiver tests. This recommendation led to the current test program managed by Sandia National Laboratories for the US Department of Energy. The 4.5 MWt receiver is installed at Sandia National Laboratories' Central Receiver Test Facility in Albuquerque, New Mexico. The receiver incorporates features of large commercial receiver designs. This report describes the receiver's configuration, heat absorption surface (design and sizing), the structure and supporting systems, and the methods for control. The receiver was solar tested during a six-month period at the Central Receiver Test Facility in Albuquerque, NM. The purpose of the testing was to characterize the operational capabilities of the receiver under a number of solar operating and stand-by conditions. This testing consisted of initial check-out of the systems, followed by steady-state performance, transient receiver operation, receiver operation in clouds, receiver thermal loss testing, receiver start-up operation, and overnight thermal conditioning tests. This report describes the design, fabrication, and results of testing of the receiver.

  14. Advanced and flexible multi-carrier receiver architecture for high-count multi-core fiber based space division multiplexed applications

    PubMed Central

    Asif, Rameez

    2016-01-01

    Space division multiplexing (SDM), incorporating multi-core fibers (MCFs), has been demonstrated for effectively maximizing the data capacity in an impending capacity crunch. To achieve high spectral-density through multi-carrier encoding while simultaneously maintaining transmission reach, benefits from inter-core crosstalk (XT) and non-linear compensation must be utilized. In this report, we propose a proof-of-concept unified receiver architecture that jointly compensates optical Kerr effects, intra- and inter-core XT in MCFs. The architecture is analysed in multi-channel 512 Gbit/s dual-carrier DP-16QAM system over 800 km 19-core MCF to validate the digital compensation of inter-core XT. Through this architecture: (a) we efficiently compensates the inter-core XT improving Q-factor by 4.82 dB and (b) achieve a momentous gain in transmission reach, increasing the maximum achievable distance from 480 km to 1208 km, via analytical analysis. Simulation results confirm that inter-core XT distortions are more relentless for cores fabricated around the central axis of cladding. Predominantly, XT induced Q-penalty can be suppressed to be less than 1 dB up-to −11.56 dB of inter-core XT over 800 km MCF, offering flexibility to fabricate dense core structures with same cladding diameter. Moreover, this report outlines the relationship between core pitch and forward-error correction (FEC). PMID:27270381

  15. Advanced and flexible multi-carrier receiver architecture for high-count multi-core fiber based space division multiplexed applications.

    PubMed

    Asif, Rameez

    2016-01-01

    Space division multiplexing (SDM), incorporating multi-core fibers (MCFs), has been demonstrated for effectively maximizing the data capacity in an impending capacity crunch. To achieve high spectral-density through multi-carrier encoding while simultaneously maintaining transmission reach, benefits from inter-core crosstalk (XT) and non-linear compensation must be utilized. In this report, we propose a proof-of-concept unified receiver architecture that jointly compensates optical Kerr effects, intra- and inter-core XT in MCFs. The architecture is analysed in multi-channel 512 Gbit/s dual-carrier DP-16QAM system over 800 km 19-core MCF to validate the digital compensation of inter-core XT. Through this architecture: (a) we efficiently compensates the inter-core XT improving Q-factor by 4.82 dB and (b) achieve a momentous gain in transmission reach, increasing the maximum achievable distance from 480 km to 1208 km, via analytical analysis. Simulation results confirm that inter-core XT distortions are more relentless for cores fabricated around the central axis of cladding. Predominantly, XT induced Q-penalty can be suppressed to be less than 1 dB up-to -11.56 dB of inter-core XT over 800 km MCF, offering flexibility to fabricate dense core structures with same cladding diameter. Moreover, this report outlines the relationship between core pitch and forward-error correction (FEC). PMID:27270381

  16. Advanced and flexible multi-carrier receiver architecture for high-count multi-core fiber based space division multiplexed applications

    NASA Astrophysics Data System (ADS)

    Asif, Rameez

    2016-06-01

    Space division multiplexing (SDM), incorporating multi-core fibers (MCFs), has been demonstrated for effectively maximizing the data capacity in an impending capacity crunch. To achieve high spectral-density through multi-carrier encoding while simultaneously maintaining transmission reach, benefits from inter-core crosstalk (XT) and non-linear compensation must be utilized. In this report, we propose a proof-of-concept unified receiver architecture that jointly compensates optical Kerr effects, intra- and inter-core XT in MCFs. The architecture is analysed in multi-channel 512 Gbit/s dual-carrier DP-16QAM system over 800 km 19-core MCF to validate the digital compensation of inter-core XT. Through this architecture: (a) we efficiently compensates the inter-core XT improving Q-factor by 4.82 dB and (b) achieve a momentous gain in transmission reach, increasing the maximum achievable distance from 480 km to 1208 km, via analytical analysis. Simulation results confirm that inter-core XT distortions are more relentless for cores fabricated around the central axis of cladding. Predominantly, XT induced Q-penalty can be suppressed to be less than 1 dB up-to ‑11.56 dB of inter-core XT over 800 km MCF, offering flexibility to fabricate dense core structures with same cladding diameter. Moreover, this report outlines the relationship between core pitch and forward-error correction (FEC).

  17. Thymidylate synthase polymorphisms in genomic DNA as clinical outcome predictors in a European population of advanced non-small cell lung cancer patients receiving pemetrexed

    PubMed Central

    2014-01-01

    Background We studied whether thymidylate synthase (TS) genotype has an independent prognostic/predictive impact on a European population of advanced non-small cell lung cancer (NSCLC) patients receiving pemetrexed. Methods Twenty-five patients treated with pemetrexed-based regimens were included. Genomic DNA was isolated prior to treatment. The variable number of tandem repeat (VNTR) polymorphisms, the G > C single nucleotide polymorphisms (SNP) and the TS 6-bp insertion/deletion (6/6) in the 3′ untranslated region (UTR) polymorphisms were analyzed and correlated with overall response rate (ORR), progression-free survival (PFS), overall-survival (OS) and toxicity. Results The genotype +6/+6 predicted a higher ORR among active/former smokers compared to +6/-6 genotype (100% vs. 50%; p = 0.085). Overall, the 3R/3R genotype predicted a higher ORR (100%) over the rest VNTR polymorphisms (p = 0.055). The presence of 3R/3R genotype significantly correlated with a superior ORR in patients without EGFR activating mutations (100%) compared to 2R/2R, 2R/3R and 3R/4R genotype (77.8%, 33.3% and 0% respectively; p = 0.017). After a median follow-up of 21 months, a trend towards a better PFS, although not significant, was found among subjects showing 3R/3R polymorphisms (p = 0.089). A significantly superior OS was found in patients showing 3R/3R genotype rather than other VNTR polymorphisms (p = 0.019). No significant correlation with the toxicity was observed. Conclusion In our series, 3R/3R polymorphism correlated with a superior OS. Also, this polymorphism, when associated to wild type EGFR, was related to a higher ORR to pemetrexed. Toxicity was not significantly correlated with a specific TS genotype. PMID:24726028

  18. “Picking up the pieces”—Meanings of receiving home nursing care when being old and living with advanced cancer in a rural area

    PubMed Central

    Devik, Siri Andreassen; Hellzen, Ove; Enmarker, Ingela

    2015-01-01

    Rural home nursing care is a neglected area in the research of palliative care offered to older cancer patients. Because access to specialized services is hampered by long distances and fragmented infrastructure, palliative care is often provided through standard home nursing services and delivered by general district nurses. This study aimed to illuminate the lived experience and to interpret the meaning of receiving home nursing care when being old and living with advanced cancer in a rural area in Norway. Narrative interviews were conducted with nine older persons, and a phenomenological hermeneutic approach was used to interpret the meaning of the lived experience. The analysis revealed three themes, each with subthemes: being content with what one gets, falling into place, and losing one's place. The phrase picking up the pieces was found useful to sum up the meaning of this lived experience. The three respective themes refer to how the pieces symbolize the remaining parts of life or available services in their environment, and how the older persons may see themselves as pieces or bricks in a puzzle. A strong place attachment (physical insideness, social insideness, and autobiographical insideness) is demonstrated by the informants in this study and suggests that the rural context may provide an advantageous healthcare environment. Its potential to be a source of comfort, security, and identity concurs with cancer patients’ strong desire for being seen as unique persons. The study shows that district nurses play an essential role in the provision of palliative care for older rural patients. However, the therapeutic value of being in one's familiar landscape seems to depend on how homecare nurses manage to locate it and use it in a more or less person-centred manner. Communication skills and attentiveness to psychosocial aspects of patient care stand out as important attributes for nursing in this context. PMID:26362533

  19. Numerical modelling of the groundwater inflow to an advancing open pit mine: Kolahdarvazeh pit, Central Iran.

    PubMed

    Bahrami, Saeed; Doulati Ardejani, Faramarz; Aslani, Soheyla; Baafi, Ernest

    2014-12-01

    The groundwater inflow into a mine during its life and after ceasing operations is one of the most important concerns of the mining industry. This paper presents a hydrogeological assessment of the Irankuh Zn-Pb mine at 20 km south of Esfahan and 1 km northeast of Abnil in west-Central Iran. During mine excavation, the upper impervious bed of a confined aquifer was broken and water at high-pressure flowed into an open pit mine associated with the Kolahdarvazeh deposit. The inflow rates were 6.7 and 1.4 m(3)/s at the maximum and minimum quantities, respectively. Permeability, storage coefficient, thickness and initial head of the fully saturated confined aquifer were 3.5 × 10(-4) m/s, 0.2, 30 m and 60 m, respectively. The hydraulic heads as a function of time were monitored at four observation wells in the vicinity of the pit over 19 weeks and at an observation well near a test well over 21 h. In addition, by measuring the rate of pumping out from the pit sump, at a constant head (usually equal to height of the pit floor), the real inflow rates to the pit were monitored. The main innovations of this work were to make comparison between numerical modelling using a finite element software called SEEP/W and actual data related to inflow and extend the applicability of the numerical model. This model was further used to estimate the hydraulic heads at the observation wells around the pit over 19 weeks during mining operations. Data from a pump-out test and observation wells were used for model calibration and verification. In order to evaluate the model efficiency, the modelling results of inflow quantity and hydraulic heads were compared to those from analytical solutions, as well as the field data. The mean percent error in relation to field data for the inflow quantity was 0.108. It varied between 1.16 and 1.46 for hydraulic head predictions, which are much lower values than the mean percent errors resulted from the analytical solutions (from 1.8 to 5

  20. Numerical modelling of the groundwater inflow to an advancing open pit mine: Kolahdarvazeh pit, Central Iran.

    PubMed

    Bahrami, Saeed; Doulati Ardejani, Faramarz; Aslani, Soheyla; Baafi, Ernest

    2014-12-01

    The groundwater inflow into a mine during its life and after ceasing operations is one of the most important concerns of the mining industry. This paper presents a hydrogeological assessment of the Irankuh Zn-Pb mine at 20 km south of Esfahan and 1 km northeast of Abnil in west-Central Iran. During mine excavation, the upper impervious bed of a confined aquifer was broken and water at high-pressure flowed into an open pit mine associated with the Kolahdarvazeh deposit. The inflow rates were 6.7 and 1.4 m(3)/s at the maximum and minimum quantities, respectively. Permeability, storage coefficient, thickness and initial head of the fully saturated confined aquifer were 3.5 × 10(-4) m/s, 0.2, 30 m and 60 m, respectively. The hydraulic heads as a function of time were monitored at four observation wells in the vicinity of the pit over 19 weeks and at an observation well near a test well over 21 h. In addition, by measuring the rate of pumping out from the pit sump, at a constant head (usually equal to height of the pit floor), the real inflow rates to the pit were monitored. The main innovations of this work were to make comparison between numerical modelling using a finite element software called SEEP/W and actual data related to inflow and extend the applicability of the numerical model. This model was further used to estimate the hydraulic heads at the observation wells around the pit over 19 weeks during mining operations. Data from a pump-out test and observation wells were used for model calibration and verification. In order to evaluate the model efficiency, the modelling results of inflow quantity and hydraulic heads were compared to those from analytical solutions, as well as the field data. The mean percent error in relation to field data for the inflow quantity was 0.108. It varied between 1.16 and 1.46 for hydraulic head predictions, which are much lower values than the mean percent errors resulted from the analytical solutions (from 1.8 to 5

  1. Preliminary design of a solar central receiver for a site-specific repowering application (Saguaro Power Plant). Volume IV. Appendixes. Final report, October 1982-September 1983

    SciTech Connect

    Weber, E.R.

    1983-09-01

    The appendixes for the Saguaro Power Plant includes the following: receiver configuration selection report; cooperating modes and transitions; failure modes analysis; control system analysis; computer codes and simulation models; procurement package scope descriptions; responsibility matrix; solar system flow diagram component purpose list; thermal storage component and system test plans; solar steam generator tube-to-tubesheet weld analysis; pipeline listing; management control schedule; and system list and definitions.

  2. The 10 MWe Solar Thermal Central Receiver Pilot Plant: Solar facilities design integration. Pilot-plant station manual (RADL Item 2-1). Volume 1: System description

    NASA Astrophysics Data System (ADS)

    1982-09-01

    The complete Barstow Solar Pilot Plant is described. The plant requirements and general description are presented, the mechanical, electric power, and control and instrumentation systems as well as civil engineering and structural aspects and the station buildings are described. Included in the mechanical systems are the heliostats, receiver, thermal storage system, beam characterization system, steam, water, nitrogen, and compressed air systems, chemical feed system, fire protection system, drains, sumps and the waste disposal systems, and heating, ventilating, and air conditioning systems.

  3. Acute Cerebrovascular Radiation Syndrome: Radiation Neurotoxicity , mechanisms of CNS radiation injury, advanced countermeasures for Radiation Protection of Central Nervous System.

    NASA Astrophysics Data System (ADS)

    Popov, Dmitri; Jones, Jeffrey; Maliev, Slava

    Key words: Cerebrovascular Acute Radiation Syndrome (Cv ARS), Radiation Neurotoxins (RNT), Neurotransmitters, Radiation Countermeasures, Antiradiation Vaccine (ArV), Antiradiation Blocking Antibodies, Antiradiation Antidote. Psychoneuroimmunology, Neurotoxicity. ABSTRACT: To review the role of Radiation Neurotoxins in triggering, developing of radiation induced central nervous system injury. Radiation Neurotoxins - rapidly acting blood toxic lethal agent, which activated after irradiation and concentrated, circulated in interstitial fluid, lymph, blood with interactions with cell membranes, receptors and cell compartments. Radiation Neurotoxins - biological molecules with high enzymatic activity and/or specific lipids and activated or modified after irradiation. The Radiation Neurotoxins induce increased permeability of blood vessels, disruption of the blood-brain barrier, blood-cerebrospinal fluid (CSF) barrier and developing severe disorder of blood macro- and micro-circulation. Principles of Radiation Psychoneuro-immunology and Psychoneuro-allergology were applied for determination of pathological processes developed after irradiation or selective administration of Radiation Neurotoxins to radiation naïve mammals. Effects of radiation and exposure to radiation can develop severe irreversible abnormalities of Central Nervous System, brain structures and functions. Antiradiation Vaccine - most effective, advanced methods of protection, prevention, mitigation and treatment and was used for of Acute Radiation Syndromes and elaboration of new technology for immune-prophylaxis and immune-protection against ϒ, Heavy Ion, Neutron irradiation. Results of experiments suggested that blocking, antitoxic, antiradiation antibodies can significantly reduce toxicity of Radiation Toxins. New advanced technology include active immune-prophylaxis with Antiradiation Vaccine and Antiradiation therapy that included specific blocking antibodies to Radiation Neurotoxins

  4. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: EOS AMSU-A1 and AMSU-A2 Receiver Assemblies

    NASA Technical Reports Server (NTRS)

    Ma, Y.

    1995-01-01

    The AMSU-A receiver subsystem comprises two separated receiver assemblies; AMSU-A1 and AMSU-A2 (P/N 1356441-1). The AMSU-A1 receiver contains 13 channels and the AMSU-A2 receiver 2 channels. The AMSU-A1 receiver assembly is further divided into two parts; AMSU-A1-1 (P/N 1356429-1) and AMSU-A1-2 (P/N 1356409-1), which contain 9 and 4 channels, respectively. The receiver assemblies are highlighted and illustrate the functional block diagrams of the AMSU-A1 and AMSU-A2 systems. The AMSU-A receiver subsystem stands in between the antenna and signal processing subsystems of the AMSU-A instrument and comprises the RF and IF components from isolators to attenuators. It receives the RF signals from the antenna subsystem, down-converts the RF signals to IF signals, amplifies and defines the IF signals to proper power level and frequency bandwidth as specified for each channel, and inputs the IF signals to the signal processing subsystem. This test report presents the test data of the EOS AMSU-A Flight Model No. 1 (FM-1) receiver subsystem. The tests are performed per the Acceptance Test Procedure for the AMSU-A Receiver Subsystem, AE-26002/6A. The functional performance tests are conducted either at the component or subsystem level. While the component-level tests are performed over the entire operating temperature range predicted by thermal analysis, the subsystem-level tests are conducted at ambient temperature only.

  5. Benchmark campaign and case study episode in central Europe for development and assessment of advanced GNSS tropospheric models and products

    NASA Astrophysics Data System (ADS)

    Douša, Jan; Dick, Galina; Kačmařík, Michal; Brožková, Radmila; Zus, Florian; Brenot, Hugues; Stoycheva, Anastasia; Möller, Gregor; Kaplon, Jan

    2016-07-01

    Initial objectives and design of the Benchmark campaign organized within the European COST Action ES1206 (2013-2017) are described in the paper. This campaign has aimed to support the development and validation of advanced Global Navigation Satellite System (GNSS) tropospheric products, in particular high-resolution and ultra-fast zenith total delays (ZTDs) and tropospheric gradients derived from a dense permanent network. A complex data set was collected for the 8-week period when several extreme heavy precipitation episodes occurred in central Europe which caused severe river floods in this area. An initial processing of data sets from GNSS products and numerical weather models (NWMs) provided independently estimated reference parameters - zenith tropospheric delays and tropospheric horizontal gradients. Their provision gave an overview about the product similarities and complementarities, and thus a potential for improvements of a synergy in their optimal exploitations in future. Reference GNSS and NWM results were intercompared and visually analysed using animated maps. ZTDs from two reference GNSS solutions compared to global ERA-Interim reanalysis resulted in accuracy at the 10 mm level in terms of the root mean square (rms) with a negligible overall bias, comparisons to Global Forecast System (GFS) forecasts showed accuracy at the 12 mm level with the overall bias of -5 mm and, finally, comparisons to mesoscale ALADIN-CZ forecast resulted in accuracy at the 8 mm level with a negligible total bias. The comparison of horizontal tropospheric gradients from GNSS and NWM data demonstrated a very good agreement among independent solutions with negligible biases and an accuracy of about 0.5 mm. Visual comparisons of maps of zenith wet delays and tropospheric horizontal gradients showed very promising results for future exploitations of advanced GNSS tropospheric products in meteorological applications, such as severe weather event monitoring and weather nowcasting

  6. CALUTRON RECEIVER

    DOEpatents

    Barnes, S.W.

    1959-08-25

    An improvement in a calutron receiver for collecting the isotopes ts described. The electromagnetic separation of the isotopes produces a mass spectrum of closely adjacent beams of ions at the foci regions, and a dividing wall between the two pockets is arranged at an angle. Substantially all of the tons of the less abundant isotope enter one of the pockets and strike one side of the wall directly, while substantially none of the tons entering the other pocket strikes the wall directly.

  7. Vegetation establishment and evolution in four ponds that received sewage and wastewater in a portion of the Olezoa wetland complex, Yaounde, Cameroon, central Africa

    SciTech Connect

    Atekwana, E.A. . Dept. of Geology); Agendia, P.L. . Dept. of Plant Biology)

    1994-04-01

    A study of the spatial and temporal changes in the pattern and distribution of tropical wetland vegetation in four ponds that received sewage and wastewater discharge, was undertaken for a small wetland ecosystem in the Olezoa drainage basin in Yaounde, Cameroon. More than 25 years of nutrient loading has led to the eutrophication and subsequent establishment of wetland vegetation in these ponds. Estimated free water surface areas of the ponds in 1964, 1976, and 1986 and 1992 determined from digitized aerial photographs and field measurements suggests a decline of 70 to 100% in the pond surface areas due to invasion and colonization by plants. The rate of pond surface decline and vegetation development is correlated with the construction of sewage plants and the discharge of untreated sewage and wastewater into the ponds. The main wetland plants that are established in the ponds consist of aquatic species Nymphae lotus, Enhydra fluctuants, Pistia stratiotes, Commelina sp., Ipomea aquatica and terrestrial species Echinochloa sp., Thalia welwitschii, Polygonum senegalense, Leersia haxandra and Cyperus papyrus. The pattern of wetland plant succession that resulted within each pond is correlated to the timing, duration and magnitude of sewage and wastewater discharge into the wetland complex.

  8. 10-MWe solar-thermal central-receiver pilot plant, solar facilities design integration: collector-field optimization report (RADL item 2-25)

    SciTech Connect

    Not Available

    1981-01-01

    Appropriate cost and performance models and computer codes have been developed to carry out the collector field optimization, as well as additional computer codes to define the actual heliostat locations in the optimized field and to compute in detail the performance to be expected of the defined field. The range of capabilities of the available optimization and performance codes is described. The role of the optimization code in the definition of the pilot plant is specified, and a complete description of the optimization process itself is given. The detailed cost model used by the optimizer for the commercial system optimization is presented in the form of equations relating the cost element to each of the factors that determine it. The design basis for the commercial system is presented together with the rationale for its selection. The development of the individual heliostat performance code is presented. Use of the individual heliostat code in a completed study of receiver panel power under sunrise startup conditions is described. The procedure whereby performance and heliostat spacing data from the representative commercial-scale system are converted into coefficients of use in the layout processor is described, and the actual procedure used in the layout processor is described. Numerous special studies in support of the pilot plant design are described. (LEW)

  9. Silicon Photo-Receivers

    NASA Astrophysics Data System (ADS)

    Zimmermann, Horst

    The properties of photodiodes being exploitable in standard bipolar, CMOS, and BiCMOS technologies are summarized. In addition examples of advanced photodiodes will be introduced in order to show how the properties of integrated photodiodes can be improved significantly by minor process modifications. Furthermore, examples of optoelectronic integrated circuits (OEICs) for such important applications like optical storage systems and optical fiber receivers are described. New trends for the circuit topology of digital-video-disk (DVD) and digital-video-recording (DVR) read-OEICs are covered. Progress of OEIC receivers for optical data transmission and communication as well as optical interconnects is also summarized.

  10. CEA and CA19.9 as early predictors of progression in advanced/metastatic colorectal cancer patients receiving oxaliplatin-based chemotherapy and bevacizumab.

    PubMed

    Petrioli, Roberto; Licchetta, Antonella; Roviello, Giandomenico; Pascucci, Alessandra; Francini, Edoardo; Bargagli, Gianluca; Conca, Raffaele; Miano, Salvatora Tindara; Marzocca, Giuseppe; Francini, Guido

    2012-01-01

    We evaluated the changes of the tumor markers CEA and CA19.9 as early predictors of progression in metastatic colorectal cancer (mCRC) patients participating in a clinical study and receiving chemotherapy and bevacizumab (Bev). Seventy-two patients had high baseline CEA or CA19.9 serum levels. By ROC analyses, the areas under the curves were 0.83 for variable CEA cutoff values for distinguishing progressive disease (PD) versus stable disease (SD)/partial remission (PR)/complete remission (CR), and 0.80 for variable CA19.9 cutoff values for distinguishing PD versus SD/PR/CR. Rises in CEA and CA19.9 may early signal the occurrence of progression in mCRC patients receiving chemotherapy and Bev. PMID:22236191

  11. Radiation receiver

    DOEpatents

    Hunt, Arlon J.

    1983-01-01

    The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles.

  12. Radiation receiver

    DOEpatents

    Hunt, A.J.

    1983-09-13

    The apparatus for collecting radiant energy and converting same to alternate energy form includes a housing having an interior space and a radiation transparent window allowing, for example, solar radiation to be received in the interior space of the housing. Means are provided for passing a stream of fluid past said window and for injecting radiation absorbent particles in said fluid stream. The particles absorb the radiation and because of their very large surface area, quickly release the heat to the surrounding fluid stream. The fluid stream particle mixture is heated until the particles vaporize. The fluid stream is then allowed to expand in, for example, a gas turbine to produce mechanical energy. In an aspect of the present invention properly sized particles need not be vaporized prior to the entrance of the fluid stream into the turbine, as the particles will not damage the turbine blades. In yet another aspect of the invention, conventional fuel injectors are provided to inject fuel into the fluid stream to maintain the proper temperature and pressure of the fluid stream should the source of radiant energy be interrupted. In yet another aspect of the invention, an apparatus is provided which includes means for providing a hot fluid stream having hot particles disbursed therein which can radiate energy, means for providing a cooler fluid stream having cooler particles disbursed therein, which particles can absorb radiant energy and means for passing the hot fluid stream adjacent the cooler fluid stream to warm the cooler fluid and cooler particles by the radiation from the hot fluid and hot particles. 5 figs.

  13. Integrated Advance Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: EOS AMSU-A1 and AMSU-A2 Receivers Assemblies

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This test report presents the test data of the EOS AMSU-A Flight Model No.1 (FM-1) receiver subsystem. The tests are performed per the Acceptance Test Procedure for the AMSU-A Reseiver Subsystem, AE-26002/6A. The functional performance tests are conducted either at the component or subsystem level. While the component-level tests are performed over the entire operating temperature range predicted by thermal analysis, the subsystem-level test are conducted at ambient temperature only.

  14. The impact of early percutaneous endoscopic gastrostomy placement on treatment completeness and nutritional status in locally advanced head and neck cancer patients receiving chemoradiotherapy.

    PubMed

    Atasoy, Beste M; Yonal, Oya; Demirel, Birsen; Dane, Faysal; Yilmaz, Yusuf; Kalayci, Cem; Abacioglu, Ufuk; Imeryuz, Nese

    2012-01-01

    To investigate the impact of early insertion of percutaneous endoscopic gastrostomy-tube on nutritional status and completeness of concurrent chemotherapy in locally advanced head and neck cancer patients treated with chemoradiotherapy. Twenty-three patients were enrolled into this prospective study. Gastrostomy-tube was inserted in patients before the initiation of chemoradiotherapy. There was not any significant change in nutritional parameters of patients that used their tube during treatment. Despite the grade 3 mucositis, the planned concurrent chemotherapy could be given in 70% of the patients. However, nine patients had weak compliance and their body weight (P = 0.01) and body mass index (P = 0.01) deteriorated in the first 4 weeks of chemoradiotherapy. The completeness of concurrent chemo-rate was 44% in these patients. Toxicity, requiring aggressive supportive care, may limit the chemotherapy part of curative concomitant chemoradiotherapy. By providing adequate enteral nutrition the insertion of gastrostomy-tube can increase the completeness rate of concurrent chemotherapy.

  15. Clinical Impact of Education Provision on Determining Advance Care Planning Decisions among End Stage Renal Disease Patients Receiving Regular Hemodialysis in University Malaya Medical Centre

    PubMed Central

    Hing (Wong), Albert; Chin, Loh Ee; Ping, Tan Li; Peng, Ng Kok; Kun, Lim Soo

    2016-01-01

    Introduction: Advance care planning (ACP) is a process of shared decision-making about future health-care plans between patients, health care providers, and family members, should patients becomes incapable of participating in medical treatment decisions. ACP discussions enhance patient's autonomy, focus on patient's values and treatment preferences, and promote patient-centered care. ACP is integrated as part of clinical practice in Singapore and the United States. Aim: To assess the clinical impact of education provision on determining ACP decisions among end-stage renal disease patients on regular hemodialysis at University Malaya Medical Centre (UMMC). To study the knowledge and attitude of patients toward ACP and end-of-life issues. Materials and Methods: Fifty-six patients were recruited from UMMC. About 43 questions pretest survey adapted from Lyon's ACP survey and Moss's cardiopulmonary resuscitation (CPR) attitude survey was given to patients to answer. An educational brochure is then introduced to these patients, and a posttest survey carried out after that. The results were analyzed using SPSS version 22.0. Results: Opinion on ACP, including CPR decisions, showed an upward trend on the importance percentage after the educational brochure exposure, but this was statistically not significant. Seventy-five percent of participants had never heard of ACP before, and only 3.6% had actually prepared a written advanced directive. Conclusion: The ACP educational brochure clinically impacts patients’ preferences and decisions toward end-of-life care; however, this is statistically not significant. Majority of patients have poor knowledge on ACP. This study lays the foundation for execution of future larger scale clinical trials, and ultimately, the incorporation of ACP into clinical practice in Malaysia. PMID:27803566

  16. Apparent diffusion coefficient values detected by diffusion-weighted imaging in the prognosis of patients with locally advanced esophageal squamous cell carcinoma receiving chemoradiation

    PubMed Central

    Liu, Shu; Zhen, Fuxi; Sun, Nana; Chen, Jiayan; Cao, Yuandong; Zhang, Sheng; Cheng, Hongyan; Ge, Xiaolin; Sun, Xinchen

    2016-01-01

    Purpose Previous studies have demonstrated that apparent diffusion coefficient (ADC) values measured by magnetic resonance imaging have prognostic value in patients with esophageal squamous cell carcinoma (ESCC). However, the role of ADC needs to be validated in a cohort of Chinese ESCC patients. This study assessed the role of ADC in predicting the outcome of patients with ESCC treated only by chemoradiation in the People’s Republic of China. Patients and methods Seventy-three patients with local advanced ESCC were retrospectively analyzed in this study; none of the patients underwent surgery before or after chemoradiation. The ADC values of the primary tumors were determined by magnetic resonance imaging. The ADC values were then correlated with clinicopathological and other radiological parameters. Survival analysis was carried out to determine if ADC had an impact on survival of these patients. Results The median ADC value of the esophageal cancer tissue was 1.256*10−3 mm2/sec (range: 0.657–2.354*10−3 mm2/sec, interquartile range 0.606*10−3 mm2/sec). No clinicopathological or radiological parameters were associated with the ADC values except the sites of tumor tissues. ADC <1.076*10−3 mm2/sec predicted significantly worse survival in patients with ESCC (12.9 months vs undefined, P=0.0108). Conclusion The ADC value is a potent prognostic factor which can be used to predict the outcome of patients with ESCC treated only by chemoradiation. PMID:27703377

  17. Evaluation of Circulating Tumor Cells and Related Events as Prognostic Factors and Surrogate Biomarkers in Advanced NSCLC Patients Receiving First-Line Systemic Treatment

    PubMed Central

    Muinelo-Romay, Laura; Vieito, Maria; Abalo, Alicia; Alonso Nocelo, Marta; Barón, Francisco; Anido, Urbano; Brozos, Elena; Vázquez, Francisca; Aguín, Santiago; Abal, Miguel; López López, Rafael

    2014-01-01

    In the present study we investigated the prognostic value of Circulating Tumour Cells (CTC) and their utility for therapy monitoring in non-small cell lung cancer (NSCLC). A total of 43 patients newly diagnosed with NSCLC were prospectively enrolled. Blood samples were obtained before the 1st, 2nd and 5th cycles of chemotherapy and analyzed using CellSearch technology. Both CTC and CTC-related objects (not morphological standard or broken epithelial cells) were counted. At baseline 18 (41.9%) patients were positive for intact CTC count and 10 (23.2%) of them had ≥5 CTC, while CK positive events were found in 79.1% of patients. The group of patients with CTC ≥5 at baseline presented worse PFS and OS than those with <5 CTC (p = 0.034 and p = 0.008, respectively). Additionally, high levels of total CK positive events were associated with poor prognosis in the group of patients with <5 CTC. Regarding therapy monitoring, patients presenting increased levels of CTC during the treatment demonstrated lower OS and PFS rates. All these data supported the value of CTC as a prognostic biomarker and as a surrogate indicator of chemotherapy effectiveness in advanced NSCLC patients, with the additional value of analyzing other “objects” such as apoptotic CTC or CK fragments to guide the clinical management of these patients. PMID:24452143

  18. Evaluation of Circulating Tumor Cells and Related Events as Prognostic Factors and Surrogate Biomarkers in Advanced NSCLC Patients Receiving First-Line Systemic Treatment.

    PubMed

    Muinelo-Romay, Laura; Vieito, Maria; Abalo, Alicia; Nocelo, Marta Alonso; Barón, Francisco; Anido, Urbano; Brozos, Elena; Vázquez, Francisca; Aguín, Santiago; Abal, Miguel; López, Rafael López

    2014-01-01

    In the present study we investigated the prognostic value of Circulating Tumour Cells (CTC) and their utility for therapy monitoring in non-small cell lung cancer (NSCLC). A total of 43 patients newly diagnosed with NSCLC were prospectively enrolled. Blood samples were obtained before the 1st, 2nd and 5th cycles of chemotherapy and analyzed using CellSearch technology. Both CTC and CTC-related objects (not morphological standard or broken epithelial cells) were counted. At baseline 18 (41.9%) patients were positive for intact CTC count and 10 (23.2%) of them had ≥5 CTC, while CK positive events were found in 79.1% of patients. The group of patients with CTC ³5 at baseline presented worse PFS and OS than those with <5 CTC (p = 0.034 and p = 0.008, respectively). Additionally, high levels of total CK positive events were associated with poor prognosis in the group of patients with <5 CTC. Regarding therapy monitoring, patients presenting increased levels of CTC during the treatment demonstrated lower OS and PFS rates. All these data supported the value of CTC as a prognostic biomarker and as a surrogate indicator of chemotherapy effectiveness in advanced NSCLC patients, with the additional value of analyzing other "objects" such as apoptotic CTC or CK fragments to guide the clinical management of these patients.

  19. eNOS polymorphisms and clinical outcome in advanced HCC patients receiving sorafenib: final results of the ePHAS study.

    PubMed

    Casadei Gardini, Andrea; Marisi, Giorgia; Faloppi, Luca; Scarpi, Emanuela; Foschi, Francesco Giuseppe; Iavarone, Massimo; Lauletta, Gianfranco; Corbelli, Jody; Valgiusti, Martina; Facchetti, Floriana; Della Corte, Cristina; Neri, Luca Maria; Tamberi, Stefano; Cascinu, Stefano; Scartozzi, Mario; Amadori, Dino; Nanni, Oriana; Tenti, Elena; Ulivi, Paola; Frassineti, Giovanni Luca

    2016-05-10

    Sorafenib may reduce endothelial nitric oxide synthase (eNOS) activity by inhibiting vascular endothelial growth factor receptors (VEGF-R), leading to a decrease in nitric oxide production. In the Italian multicenter ePHAS (eNOS polymorphisms in HCC and sorafenib) study, we analyzed the role of eNOS polymorphisms in relation to clinical outcome in patients with hepatocellular carcinoma (HCC) receiving sorafenib. Our retrospective study included a training cohort of 41 HCC patients and a validation cohort of 87 HCC patients, all undergoing sorafenib treatment. Three eNOS polymorphisms (eNOS -786T>C, eNOS VNTR 27bp 4a/b and eNOS+894G>T) were analyzed by direct sequencing or Real Time PCR in relation to progression-free survival (PFS) and overall survival (OS) (log-rank test). In univariate analysis, training cohort patients homozygous for eNOS haplotype (HT1:T-4b at eNOS-786/eNOS VNTR) had a lower median PFS (2.6 vs. 5.8 months, P < 0.0001) and OS (3.2 vs.14.6 months, P = 0.024) than those with other haplotypes. In the validation set, patients homozygous for HT1 had a lower median PFS (2.0 vs. 6.7 months, P < 0.0001) and OS (6.4 vs.18.0 months, P < 0.0001) than those with other haplotypes. Multivariate analysis confirmed this haplotype as the only independent prognostic factor. Our results suggest that haplotype HT1 in the eNOS gene may be capable of identifying a subset of HCC patients who are resistant to sorafenib. PMID:27058899

  20. eNOS polymorphisms and clinical outcome in advanced HCC patients receiving sorafenib: final results of the ePHAS study

    PubMed Central

    Faloppi, Luca; Scarpi, Emanuela; Foschi, Francesco Giuseppe; Iavarone, Massimo; Lauletta, Gianfranco; Corbelli, Jody; Valgiusti, Martina; Facchetti, Floriana; Corte, Cristina della; Neri, Luca Maria; Tamberi, Stefano; Cascinu, Stefano; Scartozzi, Mario; Amadori, Dino; Nanni, Oriana; Tenti, Elena

    2016-01-01

    Sorafenib may reduce endothelial nitric oxide synthase (eNOS) activity by inhibiting vascular endothelial growth factor receptors (VEGF-R), leading to a decrease in nitric oxide production. In the Italian multicenter ePHAS (eNOS polymorphisms in HCC and sorafenib) study, we analyzed the role of eNOS polymorphisms in relation to clinical outcome in patients with hepatocellular carcinoma (HCC) receiving sorafenib. Our retrospective study included a training cohort of 41 HCC patients and a validation cohort of 87 HCC patients, all undergoing sorafenib treatment. Three eNOS polymorphisms (eNOS -786T>C, eNOS VNTR 27bp 4a/b and eNOS+894G>T) were analyzed by direct sequencing or Real Time PCR in relation to progression-free survival (PFS) and overall survival (OS) (log-rank test). In univariate analysis, training cohort patients homozygous for eNOS haplotype (HT1:T-4b at eNOS-786/eNOS VNTR) had a lower median PFS (2.6 vs. 5.8 months, P < 0.0001) and OS (3.2 vs.14.6 months, P = 0.024) than those with other haplotypes. In the validation set, patients homozygous for HT1 had a lower median PFS (2.0 vs. 6.7 months, P < 0.0001) and OS (6.4 vs.18.0 months, P < 0.0001) than those with other haplotypes. Multivariate analysis confirmed this haplotype as the only independent prognostic factor. Our results suggest that haplotype HT1 in the eNOS gene may be capable of identifying a subset of HCC patients who are resistant to sorafenib. PMID:27058899

  1. eNOS polymorphisms and clinical outcome in advanced HCC patients receiving sorafenib: final results of the ePHAS study.

    PubMed

    Casadei Gardini, Andrea; Marisi, Giorgia; Faloppi, Luca; Scarpi, Emanuela; Foschi, Francesco Giuseppe; Iavarone, Massimo; Lauletta, Gianfranco; Corbelli, Jody; Valgiusti, Martina; Facchetti, Floriana; Della Corte, Cristina; Neri, Luca Maria; Tamberi, Stefano; Cascinu, Stefano; Scartozzi, Mario; Amadori, Dino; Nanni, Oriana; Tenti, Elena; Ulivi, Paola; Frassineti, Giovanni Luca

    2016-05-10

    Sorafenib may reduce endothelial nitric oxide synthase (eNOS) activity by inhibiting vascular endothelial growth factor receptors (VEGF-R), leading to a decrease in nitric oxide production. In the Italian multicenter ePHAS (eNOS polymorphisms in HCC and sorafenib) study, we analyzed the role of eNOS polymorphisms in relation to clinical outcome in patients with hepatocellular carcinoma (HCC) receiving sorafenib. Our retrospective study included a training cohort of 41 HCC patients and a validation cohort of 87 HCC patients, all undergoing sorafenib treatment. Three eNOS polymorphisms (eNOS -786T>C, eNOS VNTR 27bp 4a/b and eNOS+894G>T) were analyzed by direct sequencing or Real Time PCR in relation to progression-free survival (PFS) and overall survival (OS) (log-rank test). In univariate analysis, training cohort patients homozygous for eNOS haplotype (HT1:T-4b at eNOS-786/eNOS VNTR) had a lower median PFS (2.6 vs. 5.8 months, P < 0.0001) and OS (3.2 vs.14.6 months, P = 0.024) than those with other haplotypes. In the validation set, patients homozygous for HT1 had a lower median PFS (2.0 vs. 6.7 months, P < 0.0001) and OS (6.4 vs.18.0 months, P < 0.0001) than those with other haplotypes. Multivariate analysis confirmed this haplotype as the only independent prognostic factor. Our results suggest that haplotype HT1 in the eNOS gene may be capable of identifying a subset of HCC patients who are resistant to sorafenib.

  2. Advanced power assessment for Czech lignite, Task 3.6, Part 2. The 2nd international conference on energy and environment: Transitions in East Central Europe

    SciTech Connect

    Sondreal, E.A.; Mann, M.D.; Weber, G.W.; Young, B.C.

    1995-12-01

    On November 1-5, 1994, the Energy & Environmental Research Center (EERC) and Power Research Institute of Prague cosponsored their second conference since 1991 in the Czech Republic, entitled ``Energy and Environment: Transitions in East Central Europe.`` This conference was a continuation of the EERC`s joint commitment, initiated in 1190, to facilitate solutions to short- and long-term energy and environmental problems in East Central Europe. Production of energy from coal in an environmentally acceptable manner is a critical issue facing East Central Europe, because the region continues to rely on coal as its primary energy source. The goal of the conference was to develop partnerships between industry, government, and the research community in East Central Europe and the United States to solve energy and environmental issues in a manner that fosters economic development. Among the topics addressed at the conference were: conventional and advanced energy generation systems; economic operation of energy systems; air pollution controls; power system retrofitting and repowering, financing options; regulatory issues; energy resource options; waste utilization and disposal; and long-range environmental issues. Selected papers in the proceedings have been processed separately for inclusion in the Energy Science and Technology database.

  3. The European Medicines Agency review of ipilimumab (Yervoy) for the treatment of advanced (unresectable or metastatic) melanoma in adults who have received prior therapy: summary of the scientific assessment of the Committee for Medicinal Products for Human Use.

    PubMed

    Hanaizi, Zahra; van Zwieten-Boot, Barbara; Calvo, Gonzalo; Lopez, Arantxa Sancho; van Dartel, Maaike; Camarero, Jorge; Abadie, Eric; Pignatti, Francesco

    2012-01-01

    On 13 July 2011 the European Commission issued a marketing authorisation valid throughout the European Union (EU) for ipilimumab for the treatment of advanced (unresectable or metastatic) melanoma in adults who have received prior therapy. Ipilimumab is a monoclonal antibody that specifically blocks the inhibitory signal of cytotoxic T lymphocyte antigen 4 (CTLA-4), resulting in T cell activation, proliferation and lymphocyte infiltration into tumours, leading to tumour cell death. The recommended induction regimen of ipilimumab is 3mg/kg administered intravenously over a 90 min period every 3 weeks for a total of four doses. In a phase 3 trial in patients with advanced melanoma, median overall survival for ipilimumab was 10 months versus 6 months for gp100, an experimental melanoma vaccine (Hazard ratio (HR) 0.66; 95% confidence interval (CI): 0.51, 0.87; p = 0.0026). Ipilimumab was most commonly associated with adverse reactions resulting from increased or excessive immune activity. Most of these, including severe reactions, resolved following initiation of appropriate medical therapy or withdrawal of ipilimumab. The most common side-effects (affecting more than 10% of patients) were diarrhoea, rash, pruritus, fatigue, nausea, vomiting, decreased appetite and abdominal pain. The objective of this paper is to summarise the scientific review of the application leading to approval in the EU. The detailed scientific assessment report and product information, including the summary of product characteristics (SmPC), are available on the European Medicines Agency (EMA) website (www.ema.europa.eu).

  4. Hydrothermal alteration maps of the central and southern Basin and Range province of the United States compiled from Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data

    USGS Publications Warehouse

    Mars, John L.

    2013-01-01

    Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) data and Interactive Data Language (IDL) logical operator algorithms were used to map hydrothermally altered rocks in the central and southern parts of the Basin and Range province of the United States. The hydrothermally altered rocks mapped in this study include (1) hydrothermal silica-rich rocks (hydrous quartz, chalcedony, opal, and amorphous silica), (2) propylitic rocks (calcite-dolomite and epidote-chlorite mapped as separate mineral groups), (3) argillic rocks (alunite-pyrophyllite-kaolinite), and (4) phyllic rocks (sericite-muscovite). A series of hydrothermal alteration maps, which identify the potential locations of hydrothermal silica-rich, propylitic, argillic, and phyllic rocks on Landsat Thematic Mapper (TM) band 7 orthorectified images, and geographic information systems shape files of hydrothermal alteration units are provided in this study.

  5. Relative value of physical examination, mammography, and breast sonography in evaluating the size of the primary tumor and regional lymph node metastases in women receiving neoadjuvant chemotherapy for locally advanced breast carcinoma.

    PubMed

    Herrada, J; Iyer, R B; Atkinson, E N; Sneige, N; Buzdar, A U; Hortobagyi, G N

    1997-09-01

    The purpose of this study was to correlate physical examination and sonographic and mammographic measurements of breast tumors and regional lymph nodes with pathological findings and to evaluate the effect of neoadjuvant chemotherapy on clinical Tumor-Node-Metastasis stage by noninvasive methods. This was a retrospective analysis of 100 patients with locally advanced breast cancer registered and treated in prospective trials of neoadjuvant chemotherapy. All patients received four cycles of a doxorubicin-containing regimen and had noninvasive evaluation of the primary tumor and regional lymph nodes before and after neoadjuvant chemotherapy by physical examination, sonography, and mammography and underwent breast surgery and axillary dissection within 5 weeks after completion of neoadjuvant chemotherapy. The correlations between clinical and pathological measurements were determined by Spearman rank correlation analysis. A proportional odds model was used to examine predictive values. Eighty-three patients had both a clinically detectable primary tumor and lymph node metastases. Sixty-four patients had a decrease in Tumor-Node-Metastasis stage after chemotherapy. For 54% of patients, there was concordance in clinical response between the primary tumor and lymph node compartment; for the rest, results were discordant. Physical examination correlated best with pathological findings in the measurement of the primary tumor (P = 0.0003), whereas sonography was the most accurate predictor of size for axillary lymph nodes (P = 0.0005). The combination of physical examination and mammography worked best for assessment of the primary tumor (P = 0.003), whereas combining physical examination with sonography gave optimal evaluation of regional lymph nodes (P = 0.0001). In conclusion, physical examination is the best noninvasive predictor of the real size of locally advanced primary breast cancer, whereas sonography correlates better with the real dimensions of axillary lymph

  6. Advanced solar dynamic technology program

    NASA Technical Reports Server (NTRS)

    Calogeras, James

    1990-01-01

    Viewgraphs and discussion on Advanced Solar Dynamic Technology Program are presented. Topics covered include: advanced solar dynamic technology program; advanced concentrators; advanced heat receivers; power conversion systems; dished all metal honeycomb sandwich panels; Stirling cavity heat pipe receiver; Brayton solar receiver; and thermal energy storage technology.

  7. Overexpression of corticotropin releasing factor in the central nucleus of the amygdala advances puberty and disrupts reproductive cycles in female rats.

    PubMed

    Li, X F; Hu, M H; Li, S Y; Geach, C; Hikima, A; Rose, S; Greenwood, M P; Greenwood, M; Murphy, D; Poston, L; Lightman, S L; O'Byrne, K T

    2014-10-01

    Prolonged exposure to environmental stress activates the hypothalamic-pituitary-adrenal (HPA) axis and generally disrupts the hypothalamic-pituitary-gonadal axis. Because CRF expression in the central nucleus of the amygdala (CeA) is a key modulator in adaptation to chronic stress, and central administration of CRF inhibits the hypothalamic GnRH pulse generator, we tested the hypothesis that overexpression of CRF in the CeA of female rats alters anxiety behavior, dysregulates the HPA axis response to stress, changes pubertal timing, and disrupts reproduction. We used a lentiviral vector to increase CRF expression site specifically in the CeA of preweaning (postnatal day 12) female rats. Overexpression of CRF in the CeA increased anxiety-like behavior in peripubertal rats shown by a reduction in time spent in the open arms of the elevated plus maze and a decrease in social interaction. Paradoxically, puberty onset was advanced but followed by irregular estrous cyclicity and an absence of spontaneous preovulatory LH surges associated with proestrous vaginal cytology in rats overexpressing CRF. Despite the absence of change in basal corticosterone secretion or induced by stress (lipopolysaccharide or restraint), overexpression of CRF in the CeA significantly decreased lipopolysaccharide, but not restraint, stress-induced suppression of pulsatile LH secretion in postpubertal ovariectomized rats, indicating a differential stress responsivity of the GnRH pulse generator to immunological stress and a potential adaptation of the HPA axis to chronic activation of amygdaloid CRF. These data suggest that the expression profile of this key limbic brain CRF system might contribute to the complex neural mechanisms underlying the increasing incidence of early onset of puberty on the one hand and infertility on the other attributed to chronic stress in modern human society.

  8. Higher Education Administrators' Perceptions of the Academic Quality Improvement Project as Compared to the Program to Evaluate and Advance Quality within the North Central Association of Colleges and Schools

    ERIC Educational Resources Information Center

    McDonough, Jennifer Nobles

    2012-01-01

    The purpose of this study was to examine higher education administrators' perceptions of the effectiveness of the Academic Quality Improvement Project (AQIP) as compared to the Program to Evaluate and Advance Quality (PEAQ) within the North Central Association of Colleges and Schools (NCA). The Higher Learning Commission (HLC), a commission…

  9. Utility of [18F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) in the Initial Staging and Response Assessment of Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.

    PubMed

    Hulikal, Narendra; Gajjala, Sivanath Reddy; Kalawat, Teck Chand; Kottu, Radhika; Amancharla Yadagiri, Lakshmi

    2015-12-01

    In India up to 50 % of breast cancer patients still present as locally advanced breast cancer (LABC). The conventional methods of metastatic work up include physical examination, bone scan, chest & abdominal imaging, and biochemical tests. It is likely that the conventional staging underestimates the extent of initial spread and there is a need for more sophisticated staging procedure. The PET/CT can detect extra-axillary and occult distant metastases and also aid in predicting response to chemotherapy at an early point in time. To evaluate the utility of FDG PET/CT in initial staging and response assessment of patients with LABC receiving NACT. A prospective study of all biopsy confirmed female patients diagnosed with LABC receiving NACT from April 2013 to May 2014. The conventional work up included serum chemistry, CECT chest and abdomen and bone scan. A baseline whole body PET/CT was done in all patients. A repeat staging evaluation and a whole body PET/CT was done after 2/3rd cycle of NACT in non-responders and after 3/4 cycles in clinical responders. The histopathology report of the operative specimen was used to document the pathological response. The FDG PET/CT reported distant metastases in 11 of 38 patients, where as conventional imaging revealed metastases in only 6. Almost all the distant lesions detected by conventional imaging were detected with PET/CT, which showed additional sites of metastasis in 3 patients. In 2 patients, PET/CT detected osteolytic bone metastasis which were not detected by bone scan. In 5 patients PET CT detected N3 disease which were missed on conventional imaging. A total of 14 patients had second PET/CT done to assess the response to NACT and 11 patients underwent surgery. Two patients had complete pathological response. Of these 1 patient had complete metabolic and morphologic response and other had complete metabolic and partial morphologic response on second PET/CT scan. The 18 FDG PET/CT can detect more number of

  10. Utility of [18F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) in the Initial Staging and Response Assessment of Locally Advanced Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.

    PubMed

    Hulikal, Narendra; Gajjala, Sivanath Reddy; Kalawat, Teck Chand; Kottu, Radhika; Amancharla Yadagiri, Lakshmi

    2015-12-01

    In India up to 50 % of breast cancer patients still present as locally advanced breast cancer (LABC). The conventional methods of metastatic work up include physical examination, bone scan, chest & abdominal imaging, and biochemical tests. It is likely that the conventional staging underestimates the extent of initial spread and there is a need for more sophisticated staging procedure. The PET/CT can detect extra-axillary and occult distant metastases and also aid in predicting response to chemotherapy at an early point in time. To evaluate the utility of FDG PET/CT in initial staging and response assessment of patients with LABC receiving NACT. A prospective study of all biopsy confirmed female patients diagnosed with LABC receiving NACT from April 2013 to May 2014. The conventional work up included serum chemistry, CECT chest and abdomen and bone scan. A baseline whole body PET/CT was done in all patients. A repeat staging evaluation and a whole body PET/CT was done after 2/3rd cycle of NACT in non-responders and after 3/4 cycles in clinical responders. The histopathology report of the operative specimen was used to document the pathological response. The FDG PET/CT reported distant metastases in 11 of 38 patients, where as conventional imaging revealed metastases in only 6. Almost all the distant lesions detected by conventional imaging were detected with PET/CT, which showed additional sites of metastasis in 3 patients. In 2 patients, PET/CT detected osteolytic bone metastasis which were not detected by bone scan. In 5 patients PET CT detected N3 disease which were missed on conventional imaging. A total of 14 patients had second PET/CT done to assess the response to NACT and 11 patients underwent surgery. Two patients had complete pathological response. Of these 1 patient had complete metabolic and morphologic response and other had complete metabolic and partial morphologic response on second PET/CT scan. The 18 FDG PET/CT can detect more number of

  11. Physics and control of ELMing H-mode negative-central-shear advanced tokamak ITER scenario based on experimental profiles from DIII-D

    NASA Astrophysics Data System (ADS)

    Lao, L. L.; Chan, V. S.; Chu, M. S.; Evans, T.; Humphreys, D. A.; Leuer, J. A.; Mahdavi, M. A.; Petrie, T. W.; Snyder, P. B.; St. John, H. E.; Staebler, G. M.; Stambaugh, R. D.; Taylor, T. S.; Turnbull, A. D.; West, W. P.; Brennan, D. P.

    2003-10-01

    Key DIII-D advanced tokamak (AT) experimental and modelling results are applied to examine the physics and control issues for ITER to operate in a negative central shear (NCS) AT scenario. The effects of a finite edge pressure pedestal and current density are included based on the DIII-D experimental profiles. Ideal and resistive stability analyses demonstrate that feedback control of resistive wall modes by rotational drive or flux conserving intelligent coils is crucial for these AT configurations to operate at attractive bgrN values in the range 3.0-3.5. Vertical stability and halo current analyses show that reliable disruption mitigation is essential and mitigation control using an impurity gas can significantly reduce the local mechanical stress to an acceptable level. Core transport and turbulence analyses indicate that control of the rotational shear profile is essential to reduce the pedestal temperature required for high bgr. Consideration of edge stability and core transport suggests that a sufficiently wide pedestal is necessary for the projected fusion performance. Heat flux analyses indicate that, with core-only radiation enhancement, the outboard peak divertor heat load is near the design limit of 10 MW m-2. Detached operation may be necessary to reduce the heat flux to a more manageable level. Evaluation of the ITER pulse length using a local step response approach indicates that the 3000 s ITER long-pulse scenario is probably both necessary and sufficient for demonstration of local current profile control.

  12. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: METSAT (S/N 108) AMSU-A1 Receiver Assemblies, P/N 1356429-1 S/N F05 and P/N 1356409-1 S/N F05

    NASA Technical Reports Server (NTRS)

    Haigh, R.; Krimchansky, S. (Technical Monitor)

    2000-01-01

    This is the Performance Verification Report, METSAT (S/N 108) AMSU-A1 Receiver Assemblies P/N 1356429-1 S/N F05 and P/N 1356409-1 S/N F05, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A). The ATP for the AMSU-A Receiver Subsystem, AE-26002/6A, is prepared to describe in detail the configuration of the test setups and the procedures of the tests to verify that the receiver subsystem meets the specifications as required either in the AMSU-A Instrument Performance and Operation Specifications, S-480-80, or in AMSU-A Receiver Subsystem Specifications, AE-26608, derived by the Aerojet System Engineering. Test results that verify the conformance to the specifications demonstrate the acceptability of that particular receiver subsystem.

  13. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: METSAT (S/N) AMSU-A1 Receiver Assemblies P/N 1356429-1 S/N F06 and P/N 1356409-1 S/N F06

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This is the Performance Verification Report, METSAT (S/N 109) AMSU-A1 Receiver Assemblies, P/N 1356429-1 S/N F06 and P/N 1356409 S/N F06, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A).

  14. Spaceborne receivers: Basic principles

    NASA Technical Reports Server (NTRS)

    Stacey, J. M.

    1984-01-01

    The underlying principles of operation of microwave receivers for space observations of planetary surfaces were examined. The design philosophy of the receiver as it is applied to operate functionally as an efficient receiving system, the principle of operation of the key components of the receiver, and the important differences among receiver types are explained. The operating performance and the sensitivity expectations for both the modulated and total power receiver configurations are outlined. The expressions are derived from first principles and are developed through the important intermediate stages to form practicle and easily applied equations. The transfer of thermodynamic energy from point to point within the receiver is illustrated. The language of microwave receivers is applied statistics.

  15. Solar heat receiver

    DOEpatents

    Hunt, Arlon J.; Hansen, Leif J.; Evans, David B.

    1985-01-01

    A receiver for converting solar energy to heat a gas to temperatures from 700.degree.-900.degree. C. The receiver is formed to minimize impingement of radiation on the walls and to provide maximum heating at and near the entry of the gas exit. Also, the receiver is formed to provide controlled movement of the gas to be heated to minimize wall temperatures. The receiver is designed for use with gas containing fine heat absorbing particles, such as carbon particles.

  16. Solar heat receiver

    DOEpatents

    Hunt, A.J.; Hansen, L.J.; Evans, D.B.

    1982-09-29

    A receiver is described for converting solar energy to heat a gas to temperatures from 700 to 900/sup 0/C. The receiver is formed to minimize impingement of radiation on the walls and to provide maximum heating at and near the entry of the gas exit. Also, the receiver is formed to provide controlled movement of the gas to be heated to minimize wall temperatures. The receiver is designed for use with gas containing fine heat absorbing particles, such as carbon particles.

  17. Usefulness of Interim FDG-PET After Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Sequential Induction Chemotherapy Followed by Concurrent Chemoradiotherapy

    SciTech Connect

    Yoon, Dok Hyun; Cho, Yoojin; Kim, Sang Yoon; Nam, Soon Yuhl; Choi, Seung-Ho; Roh, Jong-Lyel; Lee, Sang-wook; Song, Si Yeol; Lee, Jeong Hyun; Kim, Jae Seung; Cho, Kyung-Ja; Kim, Sung-Bae

    2011-09-01

    Purpose: Induction chemotherapy (ICT) has been used to select patients for organ preservation and determine subsequent treatments in patients with locally advanced squamous cell carcinoma of the head and neck (LASCCHN). Still, the clinical outcomes of LASCCHN patients who showed response to ICT are heterogeneous. We evaluated the efficacy of interim 18-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) after ICT in this specific subgroup of LASCCHN patients who achieved partial response (PR) after ICT to predict clinical outcomes after concurrent chemoradiotherapy (CCRT). Methods and Materials: Twenty-one patients with LASCCHN who showed PR to ICT by Response Evaluation Criteria In Solid Tumors before definitive CCRT were chosen in this retrospective analysis. FDG-PET was performed before and 2-4 weeks after ICT to assess the extent of disease at baseline and the metabolic response to ICT, respectively. We examined the correlation of the metabolic response by the percentage decrease of maximum standardized uptake value (SUVmax) on the primary tumor or lymph node after ICT or a specific threshold of SUVmax on interim FDG-PET with clinical outcomes including complete response (CR) rate to CCRT, progression-free survival (PFS), and overall survival (OS). Results: A SUVmax of 4.8 on interim FDG-PET could predict clinical CR after CCRT (100% vs. 20%, p = 0.001), PFS (median, not reached vs. 8.5 mo, p < 0.001), and OS (median, not reached vs. 12.0 months, p = 0.001) with a median follow-up of 20.3 months in surviving patients. A 65% decrease in SUVmax after ICT from baseline also could predict clinical CR after CCRT (100% vs. 33.3%, p = 0.003), PFS (median, not reached vs. 8.9 months, p < 0.001) and OS (median, not reached vs. 24.4 months, p = 0.001) of the patients. Conclusion: These data suggest that interim FDG-PET after ICT might be a useful determinant to predict clinical outcomes in patients with LASCCHN receiving sequential ICT followed by CCRT.

  18. Hybrid receiver study

    NASA Technical Reports Server (NTRS)

    Stone, M. S.; Mcadam, P. L.; Saunders, O. W.

    1977-01-01

    The results are presented of a 4 month study to design a hybrid analog/digital receiver for outer planet mission probe communication links. The scope of this study includes functional design of the receiver; comparisons between analog and digital processing; hardware tradeoffs for key components including frequency generators, A/D converters, and digital processors; development and simulation of the processing algorithms for acquisition, tracking, and demodulation; and detailed design of the receiver in order to determine its size, weight, power, reliability, and radiation hardness. In addition, an evaluation was made of the receiver's capabilities to perform accurate measurement of signal strength and frequency for radio science missions.

  19. Data-fusion receiver

    SciTech Connect

    Gabelmann, Jeffrey M.; Kattner, J. Stephen; Houston, Robert A.

    2006-12-19

    This invention is an ultra-low frequency electromagnetic telemetry receiver which fuses multiple input receive sources to synthesize a decodable message packet from a noise corrupted telemetry message string. Each block of telemetry data to be sent to the surface receiver from a borehole tool is digitally encoded into a data packet prior to transmission. The data packet is modulated onto the ULF EM carrier wave and transmitted from the borehole to the surface and then are simultaneously detected by multiple receive sensors disbursed within the rig environment. The receive sensors include, but are not limited to, electric field and magnetic field sensors. The spacing of the surface receive elements is such that noise generators are unequally coupled to each receive element due to proximity and/or noise generator type (i.e. electric or magnetic field generators). The receiver utilizes a suite of decision metrics to reconstruct the original, non noise-corrupted data packet from the observation matrix via the estimation of individual data frames. The receiver will continue this estimation process until: 1) the message validates, or 2) a preset "confidence threshold" is reached whereby frames within the observation matrix are no longer "trusted".

  20. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report, METSAT (S/N:107) AMSU-A1 Receiver Assemblies: P/N 1356429-1, S/N:F04, P/N 1356409-1,S/N F04

    NASA Technical Reports Server (NTRS)

    Pines, D.

    1999-01-01

    This is the Performance Verification Report, METSAT (S/N: 107) AMSU-A1 Receiver Assemblies, P/N 1356429-1, SIN: F04, P/N 1356409- 1, S/N: F04, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A). The AMSU-A receiver subsystem comprises two separated receiver assemblies; AMSU-A1 and AMSU-A2 (P/N 1356441-1). The AMSU-A1 receiver contains 13 channels and the AMSU-A2 receiver 2 channels. The AMSU-A receiver assembly is further divided into two parts; AMSU-A I - I (P/N 13 5 6429- 1) and AMSU-A 1 -2 (P/N 1356409-1), which contain 9 and 4 channels, respectively. The AMSU-A receiver subsystem is located in between the antenna and signal processing subsystems of the AMSU-A instrument and comprises the RF and IF components from isolators to attenuators. It receives the RF signals from the antenna subsystem, down-converts the RF signals to IF signals, amplifies and defines the IF signals to proper power level and frequency bandwidth as specified for each channel, and inputs the IF signals to the signal processing subsystem. The test reports for the METSAT AMSU-A receiver subsystem are prepared separately for Al and A2 receivers so that each receiver stands alone during integration of instruments into the spacecraft. This test report presents the test data of the N4ETSAT AMSU-A1 Flight Model No. 4 (FM-4) receiver subsystem. The tests are performed per the Acceptance Test Procedure (ATP) for the AMSU-A Receiver Subsystem, AE-26002/6A. The functional performance tests are conducted either at the component or subsystem level. While the component-level tests are performed over the entire operating temperature range predicted by thermal analysis, most subsystem-level tests are conducted at ambient temperature only. Key performances (bandpass characteristics and noise figure) of the receiver subsystem are verified over the operating temperature.

  1. Mometasone Furoate Effect on Acute Skin Toxicity in Breast Cancer Patients Receiving Radiotherapy: A Phase III Double-Blind, Randomized Trial From the North Central Cancer Treatment Group N06C4

    SciTech Connect

    Miller, Robert C.; Schwartz, David J.; Sloan, Jeff A.; Griffin, Patricia C.; Deming, Richard L.; Anders, Jon C.; Stoffel, Thomas J.; Haselow, Robert E.; Schaefer, Paul L.; Bearden, James D.; Atherton, Pamela J.; Loprinzi, Charles L.; Martenson, James A.

    2011-04-01

    Purpose: A two-arm, double-blind, randomized trial was performed to evaluate the effect of 0.1% mometasone furoate (MMF) on acute skin-related toxicity in patients undergoing breast or chest wall radiotherapy. Methods and Materials: Patients with ductal carcinoma in situ or invasive breast carcinoma who were undergoing external beam radiotherapy to the breast or chest wall were randomly assigned to apply 0.1% MMF or placebo cream daily. The primary study endpoint was the provider-assessed maximal grade of Common Terminology Criteria for Adverse Events, version 3.0, radiation dermatitis. The secondary endpoints included provider-assessed Common Terminology Criteria for Adverse Events Grade 3 or greater radiation dermatitis and adverse event monitoring. The patient-reported outcome measures included the Skindex-16, the Skin Toxicity Assessment Tool, a Symptom Experience Diary, and a quality-of-life self-assessment. An assessment was performed at baseline, weekly during radiotherapy, and for 2 weeks after radiotherapy. Results: A total of 176 patients were enrolled between September 21, 2007, and December 7, 2007. The provider-assessed primary endpoint showed no difference in the mean maximum grade of radiation dermatitis by treatment arm (1.2 for MMF vs. 1.3 for placebo; p = .18). Common Terminology Criteria for Adverse Events toxicity was greater in the placebo group (p = .04), primarily from pruritus. For the patient-reported outcome measures, the maximum Skindex-16 score for the MMF group showed less itching (p = .008), less irritation (p = .01), less symptom persistence or recurrence (p = .02), and less annoyance with skin problems (p = .04). The group's maximal Skin Toxicity Assessment Tool score showed less burning sensation (p = .02) and less itching (p = .002). Conclusion: Patients receiving daily MMF during radiotherapy might experience reduced acute skin toxicity compared with patients receiving placebo.

  2. Optical antenna gain. II - Receiving antennas

    NASA Technical Reports Server (NTRS)

    Degnan, J. J.; Klein, B. J.

    1974-01-01

    Expressions are developed for the gain of a centrally obscured, circular optical antenna used as the collecting and focusing optics in a laser receiver, involving losses due to (1) incoming light blockage by central obscuration, (2) energy spillover at the detector, and (3) the effect of local oscillator distribution in the case of heterodyne or homodyne detection. Numerical results are presented for direct detection and for three types of local oscillator distribution (uniform, Gaussian, and matched).

  3. CALUTRON RECEIVER STRUCTURE

    DOEpatents

    Roush, J.L.

    1959-09-01

    A receiver is described for collecting isotopes in a calutron The receiver has several compartments, formed by a sertes of parallel metal plates and an open front. Each plate has flanges which space it from the other plates and a flexible extension pressing against a common supporting red to maintain the plate in assembled relation when all but the last rod is removed. The plates may be removed individualy from the front of the receiver, cleaned ard replaced without disturbing the alignment of the other plates.

  4. Ultrasonic pulser-receiver

    DOEpatents

    Taylor, Steven C.

    2006-09-12

    Ultrasonic pulser-receiver circuitry, for use with an ultrasonic transducer, the circuitry comprising a circuit board; ultrasonic pulser circuitry supported by the circuit board and configured to be coupled to an ultrasonic transducer and to cause the ultrasonic transducer to emit an ultrasonic output pulse; receiver circuitry supported by the circuit board, coupled to the pulser circuitry, including protection circuitry configured to protect against the ultrasonic pulse and including amplifier circuitry configured to amplify an echo, received back by the transducer, of the output pulse; and a connector configured to couple the ultrasonic transducer directly to the circuit board, to the pulser circuitry and receiver circuitry, wherein impedance mismatches that would result if the transducer was coupled to the circuit board via a cable can be avoided.

  5. Solar energy receiver

    DOEpatents

    Schwartz, Jacob

    1978-01-01

    An improved long-life design for solar energy receivers provides for greatly reduced thermally induced stress and permits the utilization of less expensive heat exchanger materials while maintaining receiver efficiencies in excess of 85% without undue expenditure of energy to circulate the working fluid. In one embodiment, the flow index for the receiver is first set as close as practical to a value such that the Graetz number yields the optimal heat transfer coefficient per unit of pumping energy, in this case, 6. The convective index for the receiver is then set as closely as practical to two times the flow index so as to obtain optimal efficiency per unit mass of material.

  6. Receiver Gain Modulation Circuit

    NASA Technical Reports Server (NTRS)

    Jones, Hollis; Racette, Paul; Walker, David; Gu, Dazhen

    2011-01-01

    A receiver gain modulation circuit (RGMC) was developed that modulates the power gain of the output of a radiometer receiver with a test signal. As the radiometer receiver switches between calibration noise references, the test signal is mixed with the calibrated noise and thus produces an ensemble set of measurements from which ensemble statistical analysis can be used to extract statistical information about the test signal. The RGMC is an enabling technology of the ensemble detector. As a key component for achieving ensemble detection and analysis, the RGMC has broad aeronautical and space applications. The RGMC can be used to test and develop new calibration algorithms, for example, to detect gain anomalies, and/or correct for slow drifts that affect climate-quality measurements over an accelerated time scale. A generalized approach to analyzing radiometer system designs yields a mathematical treatment of noise reference measurements in calibration algorithms. By treating the measurements from the different noise references as ensemble samples of the receiver state, i.e. receiver gain, a quantitative description of the non-stationary properties of the underlying receiver fluctuations can be derived. Excellent agreement has been obtained between model calculations and radiometric measurements. The mathematical formulation is equivalent to modulating the gain of a stable receiver with an externally generated signal and is the basis for ensemble detection and analysis (EDA). The concept of generating ensemble data sets using an ensemble detector is similar to the ensemble data sets generated as part of ensemble empirical mode decomposition (EEMD) with exception of a key distinguishing factor. EEMD adds noise to the signal under study whereas EDA mixes the signal with calibrated noise. It is mixing with calibrated noise that permits the measurement of temporal-functional variability of uncertainty in the underlying process. The RGMC permits the evaluation of EDA by

  7. CFD analysis of supercritical CO2 used as HTF in a solar tower receiver

    NASA Astrophysics Data System (ADS)

    Roldán, M. I.; Fernández-Reche, J.

    2016-05-01

    The relative cost of a solar receiver can be minimized by the selection of an appropriate heat transfer fluid capable of achieving high receiver efficiencies. In a conventional central receiver system, the concentrated solar energy is transferred from the receiver tube walls to the heat transfer fluid (HTF), which passes through a heat exchanger to generate steam for a Rankine cycle. Thus, higher working fluid temperature is associated with greater efficiency in receiver and power cycle. Emerging receiver designs that can enable higher efficiencies using advanced power cycles, such as supercritical CO2 (s-CO2) closed-loop Brayton cycles, include direct heating of s-CO2 in tubular receiver designs capable of withstanding high internal fluid pressures (around 20 MPa) and temperatures (900 K). Due to the high pressures required and the presence of moving components installed in pipelines (ball-joints and/or flexible connections), the use of s-CO2 presents many technical challenges due to the compatibility of seal materials and fluid leakages of the moving connections. These problems are solved in solar tower systems because the receiver is fixed. In this regard, a preliminary analysis of a tubular receiver with s-CO2 as HTF has been developed using the design of a molten-salt receiver which was previously tested at Plataforma Solar de Almería (PSA). Therefore, a simplified CFD model has been carried out in this study in order to analyze the feasibility of s-CO2 as HTF in solar towers. Simulation results showed that the heat gained by s-CO2 was around 75% greater than the one captured by molten salts (fluid inlet temperature of 715 K), but at a pressure range of 7.5-9.7 MPa. Thus, the use of s-CO2 as HTF in solar tower receivers appears to be a promising alternative, taking into account both the operating conditions required and their maintenance cost.

  8. EHF low-noise FET receiver

    NASA Technical Reports Server (NTRS)

    Schellenberg, J. M.; Watkins, E. T.

    1983-01-01

    Extremely high frequency (EHF) receivers for military and NASA programs must be small, lightweight, and highly reliable. In connection with recent advances in the development of mm-wave FET devices and circuits, a basis has been obtained for the eventual replacement of diode mixer front-ends by FET preamplifiers in receivers up to 94 GHz. By placing a low noise amplifier in front of the mixer it is possible to achieve a lower system noise figure than that found in conventional mm-wave receivers. A broader bandwidth can also be provided. Attention is given to the receiver configuration, a low noise FET amplifier, an image rejection filter, a dual-gate FET mixer, a FET local oscillator, and a FET receiver.

  9. Occurrence and distribution of fecal indicator bacteria, and physical and chemical indicators of water quality in streams receiving discharge from Dallas/Fort Worth International Airport and vicinity, North-Central Texas, 2008

    USGS Publications Warehouse

    Harwell, Glenn R.; Mobley, Craig A.

    2009-01-01

    This report, done by the U.S. Geological Survey in cooperation with Dallas/Fort Worth International (DFW) Airport in 2008, describes the occurrence and distribution of fecal indicator bacteria (fecal coliform and Escherichia [E.] coli), and the physical and chemical indicators of water quality (relative to Texas Surface Water Quality Standards), in streams receiving discharge from DFW Airport and vicinity. At sampling sites in the lower West Fork Trinity River watershed during low-flow conditions, geometric mean E. coli counts for five of the eight West Fork Trinity River watershed sampling sites exceeded the Texas Commission on Environmental Quality E. coli criterion, thus not fully supporting contact recreation. Two of the five sites with geometric means that exceeded the contact recreation criterion are airport discharge sites, which here means that the major fraction of discharge at those sites is from DFW Airport. At sampling sites in the Elm Fork Trinity River watershed during low-flow conditions, geometric mean E. coli counts exceeded the geometric mean contact recreation criterion for seven (four airport, three non-airport) of 13 sampling sites. Under low-flow conditions in the lower West Fork Trinity River watershed, E. coli counts for airport discharge sites were significantly different from (lower than) E. coli counts for non-airport sites. Under low-flow conditions in the Elm Fork Trinity River watershed, there was no significant difference between E. coli counts for airport sites and non-airport sites. During stormflow conditions, fecal indicator bacteria counts at the most downstream (integrator) sites in each watershed were considerably higher than counts at those two sites during low-flow conditions. When stormflow sample counts are included with low-flow sample counts to compute a geometric mean for each site, classification changes from fully supporting to not fully supporting contact recreation on the basis of the geometric mean contact

  10. Zero-power receiver

    DOEpatents

    Brocato, Robert W.

    2016-10-04

    An unpowered signal receiver and a method for signal reception detects and responds to very weak signals using pyroelectric devices as impedance transformers and/or demodulators. In some embodiments, surface acoustic wave devices (SAW) are also used. Illustrative embodiments include satellite and long distance terrestrial communications applications.

  11. Submillimeter wave heterodyne receiver

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Goutam (Inventor); Manohara, Harish (Inventor); Siegel, Peter H. (Inventor); Ward, John (Inventor)

    2011-01-01

    In an embodiment, a submillimeter wave heterodyne receiver includes a finline ortho-mode transducer comprising thin tapered metallic fins deposited on a thin dielectric substrate to separate a vertically polarized electromagnetic mode from a horizontally polarized electromagnetic mode. Other embodiments are described and claimed.

  12. Simplified OMEGA receivers

    NASA Technical Reports Server (NTRS)

    Burhans, R. W.

    1974-01-01

    The details are presented of methods for providing OMEGA navigational information including the receiver problem at the antenna and informational display and housekeeping systems based on some 4 bit data processing concepts. Topics discussed include the problem of limiters, zero crossing detectors, signal envelopes, internal timing circuits, phase counters, lane position displays, signal integrators, and software mapping problems.

  13. Olympus beacon receiver

    NASA Technical Reports Server (NTRS)

    Ostergaard, Jens

    1988-01-01

    A medium-size Beacon Receiving System for reception and processing of the B1 (20 GHz) and B2 (30 GHz) beacons from Olympus has been developed. Integration of B1 and B2 receiving equipment into one system using one antenna and a common computer for control and data processing provides the advantages of a compact configuration and synchronization of the two receiver chains. Range for co-polar signal attenuation meaurement is about 30 dB for both beacons, increasing to 40 dB for B2 if the receivers are synchronized to B1. The accuracy is better than 0.5 dB. Cross-polarization discriminations of the order of 10 to 30 dB may be determined with an accuracy of 1 to 2 dB. A number of radiometers for complementary measurements of atmospheric attenuation of 13 to 30 GHz has also been constructed. A small multi-frequency system for operation around 22 GHz and 31 GHz is presently under development.

  14. Hanson receives Macelwane Medal

    NASA Astrophysics Data System (ADS)

    Ravishankara, A. R.; Hanson, David R.

    At the 1996 Spring Meeting in Baltimore, Maryland, David R. Hanson received the 1996 James B. Macelwane Medal, which recognizes significant contributions to the geophysical sciences by a young scientist of outstanding ability. The medal citation and Hanson's response are given here.

  15. Reconfigurable optical transmitters and receivers

    NASA Astrophysics Data System (ADS)

    Freude, Wolfgang; Schmogrow, René; Hillerkuss, David; Meyer, Joachim; Dreschmann, Michael; Nebendahl, Bernd; Huebner, Michael; Becker, Juergen; Koos, Christian; Leuthold, Juerg

    2012-01-01

    Recent advances in electronic data processing allow constructing reconfigurable optical transmitters and receivers, where modulation formats and symbol rates are set by software-controlled field programmable gate arrays (FPGA). We report on such a real-time optical transmitter for 8 modulation formats, which can be swapped in 5 ns without data loss. With single-polarization 64QAM symbols generated at 28 GBd, we transmit data at 168 Gbit/s in real time. A similar arrangement defines a single-polarization orthogonal frequency division multiplexing (OFDM) transmitter for a data rate of 101.5 Gbit/s, where 58 subcarriers are encoded with 16QAM data. With a different software setup, the FPGA realizes an optical 56 Gbit/s transmitter for sinc-shaped so-called Nyquist pulses, the spectrum of which is rectangular having the minimum theoretically achievable bandwidth (suitable for Nyquist wavelength division multiplexing, N-WDM). For terabit OFDM reception, optical pre-processing is required to demultiplex high-bitrate signals down to lower-bitrate tributaries, which then can be processed electronically. We discuss a 10.8 Tbit/s (26 Tbit/s) receiver employing an all-optical fast Fourier transform to demultiplex 75 (325) optical subcarriers modulated with 16QAM-formated symbols at a rate of 18 GBd (10 GBd). Groups with any number of subcarriers can be selected with a simple hardware reconfiguration step.

  16. A digital beacon receiver

    NASA Technical Reports Server (NTRS)

    Ransome, Peter D.

    1988-01-01

    A digital satellite beacon receiver is described which provides measurement information down to a carrier/noise density ratio approximately 15 dB below that required by a conventional (phase locked loop) design. When the beacon signal fades, accuracy degrades gracefully, and is restored immediately (without hysteresis) on signal recovery, even if the signal has faded into the noise. Benefits of the digital processing approach used include the minimization of operator adjustments, stability of the phase measuring circuits with time, repeatability between units, and compatibility with equipment not specifically designed for propagation measuring. The receiver has been developed for the European Olympus satellite which has continuous wave (CW) beacons at 12.5 and 29.7 GHz, and a switched polarization beacon at 19.8 GHz approximately, but the system can be reconfigured for CW and polarization-switched beacons at other frequencies.

  17. Multichannel homodyne receiver

    DOEpatents

    Landt, Jeremy A.

    1982-01-01

    A homodyne radar transmitter/receiver device which produces a single combined output which contains modulated backscatter information for all phase conditions of both modulated and unmodulated backscatter signals. The device utilizes taps along coaxial transmission lines, strip transmission line, and waveguides which are spaced by 1/8 wavelength or 1/6 wavelength, etc. This greatly reduces costs by eliminating separate transmission and reception antennas and an expensive arrangement of power splitters and mixers utilized in the prior art.

  18. Multichannel homodyne receiver

    DOEpatents

    Landt, J.A.

    1981-01-19

    A homodyne radar transmitter/receiver device which produces a single combined output which contains modulated backscatter information for all phase conditions of both modulated and unmodulated backscatter signals is described. The device utilizes taps along coaxial transmission lines, strip transmission line, and waveguides which are spaced by 1/8 wavelength or 1/6 wavelength, etc. This greatly reduces costs by eliminating separate transmission and reception antennas and an expensive arrangement of power splitters and mixers utilized in the prior art.

  19. Design of radar receivers

    NASA Astrophysics Data System (ADS)

    Sokolov, M. A.

    This handbook treats the design and analysis of of pulsed radar receivers, with emphasis on elements (especially IC elements) that implement optimal and suboptimal algorithms. The design methodology is developed from the viewpoint of statistical communications theory. Particular consideration is given to the synthesis of single-channel and multichannel detectors, the design of analog and digital signal-processing devices, and the analysis of IF amplifiers.

  20. Central line complications

    PubMed Central

    Kornbau, Craig; Lee, Kathryn C; Hughes, Gwendolyn D; Firstenberg, Michael S

    2015-01-01

    Central venous access is a common procedure performed in many clinical settings for a variety of indications. Central lines are not without risk, and there are a multitude of complications that are associated with their placement. Complications can present in an immediate or delayed fashion and vary based on type of central venous access. Significant morbidity and mortality can result from complications related to central venous access. These complications can cause a significant healthcare burden in cost, hospital days, and patient quality of life. Advances in imaging, access technique, and medical devices have reduced and altered the types of complications encountered in clinical practice; but most complications still center around vascular injury, infection, and misplacement. Recognition and management of central line complications is important when caring for patients with vascular access, but prevention is the ultimate goal. This article discusses common and rare complications associated with central venous access, as well as techniques to recognize, manage, and prevent complications. PMID:26557487

  1. Ultra-wideband receiver

    DOEpatents

    McEwan, Thomas E.

    1996-01-01

    An ultra-wideband (UWB) receiver utilizes a strobed input line with a sampler connected to an amplifier. In a differential configuration, .+-.UWB inputs are connected to separate antennas or to two halves of a dipole antenna. The two input lines include samplers which are commonly strobed by a gating pulse with a very low duty cycle. In a single ended configuration, only a single strobed input line and sampler is utilized. The samplers integrate, or average, up to 10,000 pulses to achieve high sensitivity and good rejection of uncorrelated signals.

  2. Ultra-wideband receiver

    DOEpatents

    McEwan, Thomas E.

    1994-01-01

    An ultra-wideband (UWB) receiver utilizes a strobed input line with a sampler connected to an amplifier. In a differential configuration, .+-.UWB inputs are connected to separate antennas or to two halves of a dipole antenna. The two input lines include samplers which are commonly strobed by a gating pulse with a very low duty cycle. In a single ended configuration, only a single strobed input line and sampler is utilized. The samplers integrate, or average, up to 10,000 pulses to achieve high sensitivity and good rejection of uncorrelated signals.

  3. Ultra-wideband receiver

    DOEpatents

    McEwan, T.E.

    1996-06-04

    An ultra-wideband (UWB) receiver utilizes a strobed input line with a sampler connected to an amplifier. In a differential configuration, {+-}UWB inputs are connected to separate antennas or to two halves of a dipole antenna. The two input lines include samplers which are commonly strobed by a gating pulse with a very low duty cycle. In a single ended configuration, only a single strobed input line and sampler is utilized. The samplers integrate, or average, up to 10,000 pulses to achieve high sensitivity and good rejection of uncorrelated signals. 21 figs.

  4. Ultra-wideband receiver

    DOEpatents

    McEwan, T.E.

    1994-09-06

    An ultra-wideband (UWB) receiver utilizes a strobed input line with a sampler connected to an amplifier. In a differential configuration, [+-] UWB inputs are connected to separate antennas or to two halves of a dipole antenna. The two input lines include samplers which are commonly strobed by a gating pulse with a very low duty cycle. In a single ended configuration, only a single strobed input line and sampler is utilized. The samplers integrate, or average, up to 10,000 pulses to achieve high sensitivity and good rejection of uncorrelated signals. 16 figs.

  5. Centralized Accounting and Electronic Filing Provides Efficient Receivables Collection.

    ERIC Educational Resources Information Center

    School Business Affairs, 1983

    1983-01-01

    An electronic filing system makes financial control manageable at Bowling Green State University, Ohio. The system enables quick access to computer-stored consolidated account data and microfilm images of charges, statements, and other billing documents. (MLF)

  6. Solar augmentation for process heat with central receiver technology

    NASA Astrophysics Data System (ADS)

    Kotzé, Johannes P.; du Toit, Philip; Bode, Sebastian J.; Larmuth, James N.; Landman, Willem A.; Gauché, Paul

    2016-05-01

    Coal fired boilers are currently one of the most widespread ways to deliver process heat to industry. John Thompson Boilers (JTB) offer industrial steam supply solutions for industry and utility scale applications in Southern Africa. Transport cost add significant cost to the coal price in locations far from the coal fields in Mpumalanga, Gauteng and Limpopo. The Helio100 project developed a low cost, self-learning, wireless heliostat technology that requires no ground preparation. This is attractive as an augmentation alternative, as it can easily be installed on any open land that a client may have available. This paper explores the techno economic feasibility of solar augmentation for JTB coal fired steam boilers by comparing the fuel savings of a generic 2MW heliostat field at various locations throughout South Africa.

  7. Terahertz Array Receivers with Integrated Antennas

    NASA Technical Reports Server (NTRS)

    Chattopadhyay, Goutam; Llombart, Nuria; Lee, Choonsup; Jung, Cecile; Lin, Robert; Cooper, Ken B.; Reck, Theodore; Siles, Jose; Schlecht, Erich; Peralta, Alessandro; Thomas, Bertrand; Mehdi, Imran

    2011-01-01

    Highly sensitive terahertz heterodyne receivers have been mostly single-pixel. However, now there is a real need of multi-pixel array receivers at these frequencies driven by the science and instrument requirements. In this paper we explore various receiver font-end and antenna architectures for use in multi-pixel integrated arrays at terahertz frequencies. Development of wafer-level integrated terahertz receiver front-end by using advanced semiconductor fabrication technologies has progressed very well over the past few years. Novel stacking of micro-machined silicon wafers which allows for the 3-dimensional integration of various terahertz receiver components in extremely small packages has made it possible to design multi-pixel heterodyne arrays. One of the critical technologies to achieve fully integrated system is the antenna arrays compatible with the receiver array architecture. In this paper we explore different receiver and antenna architectures for multi-pixel heterodyne and direct detector arrays for various applications such as multi-pixel high resolution spectrometer and imaging radar at terahertz frequencies.

  8. Weather Data Receiver

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Northern Video Graphics, Inc. developed a low-cost satellite receiving system for users such as independent meteorologists, agribusiness firms, small airports or flying clubs, marine vessels and small TV stations. Called Video Fax, it is designed for use with certain satellites; the GOES (Geostationary Operational Environmental Satellite) spacecraft operated by the National Oceanic and Atmospheric Administration, the European Space Agency's Meteosat and Japan's Geostationary Meteorological Satellite. By dictum of the World Meteorological Organization, signals from satellites are available to anyone without cost so the Video Fax user can acquire signals directly from the satellite and cut out the middle man, enabling savings. Unit sells for about one-fifth the cost of the equipment used by TV stations. It consists of a two-meter antenna; a receiver; a microprocessor-controlled display computer; and a video monitor. Computer stores data from the satellites and converts it to an image which is displayed on the monitor. Weather map can be preserved as signal data on tape, or it can be stored in a video cassette as a permanent image.

  9. ASNT central certification program

    NASA Astrophysics Data System (ADS)

    Spring, Robert W.; Snell, John R., Jr.

    1997-04-01

    The American Society of Nondestructive Testing (ASNT) has recently established a new central certification program. This program will allow individuals who meet the requirements to receive a 'portable' certificate. Augmenting the existing employer-based certification, this program will have significant impact on industries that may ultimately require nondestructive testing (NDT) personnel to have central certification. This paper explains show ASNT has structured central certification and when and how it will effect thermal/infrared thermography (T/IRT) personnel. The paper also discusses the industry specific certification process.

  10. Digital Receiver Phase Meter

    NASA Technical Reports Server (NTRS)

    Marcin, Martin; Abramovici, Alexander

    2008-01-01

    The software of a commercially available digital radio receiver has been modified to make the receiver function as a two-channel low-noise phase meter. This phase meter is a prototype in the continuing development of a phase meter for a system in which radiofrequency (RF) signals in the two channels would be outputs of a spaceborne heterodyne laser interferometer for detecting gravitational waves. The frequencies of the signals could include a common Doppler-shift component of as much as 15 MHz. The phase meter is required to measure the relative phases of the signals in the two channels at a sampling rate of 10 Hz at a root power spectral density <5 microcycle/(Hz)1/2 and to be capable of determining the power spectral density of the phase difference over the frequency range from 1 mHz to 1 Hz. Such a phase meter could also be used on Earth to perform similar measurements in laser metrology of moving bodies. To illustrate part of the principle of operation of the phase meter, the figure includes a simplified block diagram of a basic singlechannel digital receiver. The input RF signal is first fed to the input terminal of an analog-to-digital converter (ADC). To prevent aliasing errors in the ADC, the sampling rate must be at least twice the input signal frequency. The sampling rate of the ADC is governed by a sampling clock, which also drives a digital local oscillator (DLO), which is a direct digital frequency synthesizer. The DLO produces samples of sine and cosine signals at a programmed tuning frequency. The sine and cosine samples are mixed with (that is, multiplied by) the samples from the ADC, then low-pass filtered to obtain in-phase (I) and quadrature (Q) signal components. A digital signal processor (DSP) computes the ratio between the Q and I components, computes the phase of the RF signal (relative to that of the DLO signal) as the arctangent of this ratio, and then averages successive such phase values over a time interval specified by the user.

  11. Solar thermal energy receiver

    NASA Technical Reports Server (NTRS)

    Baker, Karl W. (Inventor); Dustin, Miles O. (Inventor)

    1992-01-01

    A plurality of heat pipes in a shell receive concentrated solar energy and transfer the energy to a heat activated system. To provide for even distribution of the energy despite uneven impingement of solar energy on the heat pipes, absence of solar energy at times, or failure of one or more of the heat pipes, energy storage means are disposed on the heat pipes which extend through a heat pipe thermal coupling means into the heat activated device. To enhance energy transfer to the heat activated device, the heat pipe coupling cavity means may be provided with extensions into the device. For use with a Stirling engine having passages for working gas, heat transfer members may be positioned to contact the gas and the heat pipes. The shell may be divided into sections by transverse walls. To prevent cavity working fluid from collecting in the extensions, a porous body is positioned in the cavity.

  12. Low-temperature volumetric receiver concept

    NASA Astrophysics Data System (ADS)

    Drost, M. K.

    1988-09-01

    This document describes an alternative solar central receiver concept that offers the potential for a substantial reduction in the cost of electrical energy. The concept consists of a low temperature volumetric receiver which supplies 1100 F air to a Kalina cycle heat engine. Hot air can also be supplied to a packed bed of Dresser basalt where the hot air is used to heat the bed. The thermal energy stored in the bed can be extracted and supplied to the Kalina cycle during periods of low insolation. Previous investigations of the volumetric receiver concentrated on high temperature applications. The results showed that the volumetric concept could be very efficient, but the receiver was expensive and there were significant technical problems. Areas of technical uncertainty included fiber durability, the feasibility of inducing a preswirl and cost effective applications. The use of the volumetric receiver to produce low temperature will avoid the problems identified in the high temperature studies. The attractiveness of the low temperature concept is enhanced by the availability of the Kalina cycle. This heat engine was developed as a bottoming cycle for Brayton and Rankine cycle power plants. The key feature of the Kalina cycle is its ability to efficiently utilize the energy in a relatively low temperature heat source. The combination of the low temperature volumetric receiver and the Kalina cycle is particularly interesting.

  13. Low-temperature volumetric receiver concept

    SciTech Connect

    Drost, M.K.

    1988-09-01

    This document describes an alternative solar central receiver concept that offers the potential for a substantial reduction in the cost of electrical energy. The concept consists of a low temperature volumetric receiver which supplies 1100/degree/F air to a Kalina cycle heat engine. Hot air can also be supplied to a packed bed of Dresser basalt where the hot air is used to heat the bed. The thermal energy stored in the bed can be extracted and supplied to the Kalina cycle during periods of low insolation. Previous investigations of the volumetric receiver concentrated on high temperature applications. The results showed that the volumetric concept could be very efficient, but the receiver was expensive and there were significant technical problems. Areas of technical uncertainty included fiber durability, the feasibility of inducing a preswirl and cost effective applications. The use of the volumetric receiver to produce low temperature will avoid the problems identified in the high temperature studies. The attractiveness of the low temperature concept is enhanced by the availability of the Kalina cycle. This heat engine was developed as a bottoming cycle for Brayton and Rankine cycle power plants. The key feature of the Kalina cycle is its ability to efficiently utilize the energy in a relatively low temperature heat source. The combination of the low temperature volumetric receiver and the Kalina cycle is particularly interesting. 7 refs., 2 figs., 3 tabs.

  14. ADVANCED GAS TURBINE SYSTEMS RESEARCH PROGRAM

    SciTech Connect

    Lawrence P. Golan

    2003-05-01

    The activities of the Advanced Gas Turbine Systems Research (AGTSR) program for the reporting period October 1, 2002 to December 31, 2002 are described in this quarterly report. No new membership, workshops, research projects, internships, faculty fellowships or special studies were initiated during this reporting period. Contract completion is set for June 30, 2003. During the report period, six research progress reports were received (3 final reports and 3 semi-annual reports). The University of Central Florida contract SR080 was terminated during this period, as UCF was unable to secure research facilities. AGTSR now projects that it will under spend DOE obligated funds by approximately 340-350K$.

  15. Digital Signal Processor For GPS Receivers

    NASA Technical Reports Server (NTRS)

    Thomas, J. B.; Meehan, T. K.; Srinivasan, J. M.

    1989-01-01

    Three innovative components combined to produce all-digital signal processor with superior characteristics: outstanding accuracy, high-dynamics tracking, versatile integration times, lower loss-of-lock signal strengths, and infrequent cycle slips. Three components are digital chip advancer, digital carrier downconverter and code correlator, and digital tracking processor. All-digital signal processor intended for use in receivers of Global Positioning System (GPS) for geodesy, geodynamics, high-dynamics tracking, and ionospheric calibration.

  16. Counterrotator And Correlator For GPS Receivers

    NASA Technical Reports Server (NTRS)

    Thomas, J. Brooks; Srinivasan, Jeffrey M.; Meehan, Thomas K.

    1989-01-01

    Accurate, all-digital, high-speed processor comprising correlator and down-converter developed for receivers in Global Positioning System (GPS). Processor reduces roundoff and commensurability errors to extremely small values. Use of digital chip and phase advancers provides outstanding control and accuracy in phase and feedback. Great flexibility imparted by provision for arbitrary starting time and integration length. Minimum-bit design requires minimum number of logical elements, thereby reducing size, power, and cost.

  17. Prognosis Can Be Predicted More Accurately Using Pre- and Postchemoradiotherapy Carcinoembryonic Antigen Levels Compared to Only Prechemoradiotherapy Carcinoembryonic Antigen Level in Locally Advanced Rectal Cancer Patients Who Received Neoadjuvant Chemoradiotherapy

    PubMed Central

    Sung, SooYoon; Son, Seok Hyun; Kay, Chul Seung; Lee, Yoon Suk

    2016-01-01

    Abstract We aimed to evaluate the prognostic value of a change in the carcinoembryonic antigen (CEA) level during neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer. A total of 110 patients with clinical T3/T4 or node-positive disease underwent nCRT and curative total mesorectal resection from February 2006 to December 2013. Serum CEA level was measured before nCRT, after nCRT, and then again after surgery. A cut-off value for CEA level to predict prognosis was determined using the maximally selected log-rank test. According to the test, patients were classified into 3 groups, based on their CEA levels (Group A: pre-CRT CEA ≤3.2; Group B: pre-CRT CEA level >3.2 and post-CRT CEA ≤2.8; and Group C: pre-CRT CEA >3.2 and post-CRT CEA >2.8). The median follow-up time was 31.1 months. The 3-year disease-free survival (DFS) rates of Group A and Group B were similar, while Group C showed a significantly lower 3-year DFS rate (82.5% vs. 89.5% vs. 55.1%, respectively, P = 0.001). Other clinicopathological factors that showed statistical significance on univariate analysis were pre-CRT CEA, post-CRT CEA, tumor distance from the anal verge, surgery type, downstage, pathologic N stage, margin status and perineural invasion. The CEA group (P = 0.001) and tumor distance from the anal verge (P = 0.044) were significant prognostic factors for DFS on multivariate analysis. Post-CRT CEA level may be a useful prognostic factor in patients whose prognosis cannot be predicted exactly by pre-CRT CEA levels alone in the neoadjuvant treatment era. Combined pre-CRT CEA and post-CRT CEA levels enable us to predict prognosis more accurately and determine treatment and follow-up policies. Further large-scale studies are necessary to validate the prognostic value of CEA levels. PMID:26962798

  18. ChlVPP alternating with PABlOE is superior to PABlOE alone in the initial treatment of advanced Hodgkin's disease: results of a British National Lymphoma Investigation/Central Lymphoma Group randomized controlled trial

    PubMed Central

    Hancock, B W; Gregory, W M; Cullen, M H; Hudson, G Vaughan; Burton, A; Selby, P; Maclennan, K A; Jack, A; Bessell, E M; Smith, P; Linch, D C

    2001-01-01

    The purpose of this randomized trial was to compare the efficacy of 6 cycles of prednisolone, Adriamycin (doxorubicin), bleomycin, vincristine (Oncovin) and etoposide (PABlOE) with 3 cycles of PABIOE that alternate with 3 cycles of chlorambucil, vinblastine, procarbazine and prednisone (ChlVPP) in patients with advanced Hodgkin's disease. Between October 1992 and April 1996, 679 patients were entered onto the study. 41 of these did not match the protocol requirements on review and were excluded from further analysis, most of these being reclassified as NHL on histological review. Of the remaining 638 patients, 319 were allocated to receive PABIOE and 319 were allocated to receive ChlVPP/PABlOE. The complete remission (CR) rates were 78% and 64%, for ChlVPP/PABlOE and PABIOE respectively after initial chemotherapy (P< 0.0001). 124 patients were re-evaluated subsequently following radiotherapy to residual masses. The CR rates changed from 78% to 88% for ChlVPP/PABlOE and from 64% to 77% for PABlOE when re-evaluated in this manner (treatment difference still significant P = 0.0002). The treatment associated mortality in the PABlOE arm was 2.2% (7 deaths), while there were no such deaths in the ChlVPP/PABlOE arm (P = 0.015). The failure-free survival was significantly greater in the ChlVPP/PABlOE arm (P< 0.0001) as was the overall survival (P = 0.01). The failure-free and overall survival rates at 3 years were 77% and 91% in the ChlVPP/PABlOE arm, compared with 58% and 85% in the PABIOE arm, respectively. These results indicate that ChlVPP alternating with PABIOE is superior to PABIOE alone as initial treatment for advanced Hodgkin's disease.© 2001 Cancer Research Campaign www.bjcancer.com PMID:11355937

  19. Projected techno-economic improvements for advanced solar thermal power plants

    NASA Technical Reports Server (NTRS)

    Fujita, T.; Manvi, R.; Roschke, E. J.

    1979-01-01

    The projected characteristics of solar thermal power plants (with outputs up to 10 MWe) employing promising advanced technology subsystems/components are compared to current (or pre-1985) steam-Rankine systems. Improvements accruing to advanced technology development options are delineated. The improvements derived from advanced systems result primarily from achieving high efficiencies via solar collector systems which (1) capture a large portion of the available insolation and (2) concentrate this captured solar flux to attain high temperatures required for high heat engine/energy conversion performance. The most efficient solar collector systems employ two-axis tracking. Attractive systems include the central receiver/heliostat and the parabolic dish.

  20. Real-time software receiver

    NASA Technical Reports Server (NTRS)

    Ledvina, Brent M. (Inventor); Psiaki, Mark L. (Inventor); Powell, Steven P. (Inventor); Kintner, Jr., Paul M. (Inventor)

    2007-01-01

    A real-time software receiver that executes on a general purpose processor. The software receiver includes data acquisition and correlator modules that perform, in place of hardware correlation, baseband mixing and PRN code correlation using bit-wise parallelism.

  1. Real-time software receiver

    NASA Technical Reports Server (NTRS)

    Ledvina, Brent M. (Inventor); Psiaki, Mark L. (Inventor); Powell, Steven P. (Inventor); Kintner, Jr., Paul M. (Inventor)

    2006-01-01

    A real-time software receiver that executes on a general purpose processor. The software receiver includes data acquisition and correlator modules that perform, in place of hardware correlation, baseband mixing and PRN code correlation using bit-wise parallelism.

  2. Performance outlook of the SCRAP receiver

    NASA Astrophysics Data System (ADS)

    Lubkoll, Matti; von Backström, Theodor W.; Harms, Thomas M.

    2016-05-01

    A combined cycle (CC) concentrating solar power (CSP) plant provides significant potential to achieve an efficiency increase and an electricity cost reduction compared to current single-cycle plants. A CC CSP system requires a receiver technology capable of effectively transferring heat from concentrated solar irradiation to a pressurized air stream of a gas turbine. The small number of pressurized air receivers demonstrated to date have practical limitations, when operating at high temperatures and pressures. As yet, a robust, scalable and efficient system has to be developed and commercialized. A novel receiver system, the Spiky Central Receiver Air Pre-heater (SCRAP) concept has been proposed to comply with these requirements. The SCRAP system is conceived as a solution for an efficient and robust pressurized air receiver that could be implemented in CC CSP concepts or standalone solar Brayton cycles without a bottoming Rankine cycle. The presented work expands on previous publications on the thermal modeling of the receiver system. Based on the analysis of a single heat transfer element (spike), predictions for its thermal performance can be made. To this end the existing thermal model was improved by heat transfer characteristics for the jet impingement region of the spike tip as well as heat transfer models simulating the interaction with ambient. While the jet impingement cooling effect was simulated employing a commercial CFD code, the ambient heat transfer model was based on simplifying assumptions in order to employ empirical and analytical equations. The thermal efficiency of a spike under design conditions (flux 1.0 MW/m2, air outlet temperature just below 800 °C) was calculated at approximately 80 %, where convective heat losses account for 16.2 % of the absorbed radiation and radiative heat losses for a lower 2.9 %. This effect is due to peak surface temperatures occurring at the root of the spikes. It can thus be concluded that the geometric

  3. High temperature solar thermal receiver

    NASA Technical Reports Server (NTRS)

    1979-01-01

    A design concept for a high temperature solar thermal receiver to operate at 3 atmospheres pressure and 2500 F outlet was developed. The performance and complexity of windowed matrix, tube-header, and extended surface receivers were evaluated. The windowed matrix receiver proved to offer substantial cost and performance benefits. An efficient and cost effective hardware design was evaluated for a receiver which can be readily interfaced to fuel and chemical processes or to heat engines for power generation.

  4. Bragg-cell receiver study

    NASA Technical Reports Server (NTRS)

    Wilson, Lonnie A.

    1987-01-01

    Bragg-cell receivers are employed in specialized Electronic Warfare (EW) applications for the measurement of frequency. Bragg-cell receiver characteristics are fully characterized for simple RF emitter signals. This receiver is early in its development cycle when compared to the IFM receiver. Functional mathematical models are derived and presented in this report for the Bragg-cell receiver. Theoretical analysis is presented and digital computer signal processing results are presented for the Bragg-cell receiver. Probability density function analysis are performed for output frequency. Probability density function distributions are observed to depart from assumed distributions for wideband and complex RF signals. This analysis is significant for high resolution and fine grain EW Bragg-cell receiver systems.

  5. Sensible heat receiver for solar dynamic space power system

    NASA Technical Reports Server (NTRS)

    Perez-Davis, Marla E.; Gaier, James R.; Petrefski, Chris

    1991-01-01

    A sensible heat receiver is considered which uses a vapor grown carbon fiber-carbon (VGCF/C) composite as the thermal storage medium and which was designed for a 7-kW Brayton engine. This heat receiver stores the required energy to power the system during eclipse in the VGCF/C composite. The heat receiver thermal analysis was conducted through the Systems Improved Numerical Differencing Analyzer and Fluid Integrator (SINDA) software package. The sensible heat receiver compares well with other latent and advanced sensible heat receivers analyzed in other studies, while avoiding the problems associated with latent heat storage salts and liquid metal heat pipes. The concept also satisfies the design requirements for a 7-kW Brayton engine system. The weight and size of the system can be optimized by changes in geometry and technology advances for this new material.

  6. Sensible heat receiver for solar dynamic space power system

    NASA Technical Reports Server (NTRS)

    Perez-Davis, Marla E.; Gaier, James R.; Petrefski, Chris

    1991-01-01

    A sensible heat receiver considered in this study uses a vapor grown carbon fiber-carbon (VGCF/C) composite as the thermal storage media and was designed for a 7 kW Brayton engine. The proposed heat receiver stores the required energy to power the system during eclipse in the VGCF/C composite. The heat receiver thermal analysis was conducted through the Systems Improved Numerical Differencing Analyzer and Fluid Integrator (SINDA) software package. The sensible heat receiver compares well with other latent and advanced sensible heat receivers analyzed in other studies while avoiding the problems associated with latent heat storage salts and liquid metal heat pipes. The concept also satisfies the design requirements for a 7 kW Brayton engine system. The weight and size of the system can be optimized by changes in geometry and technology advances for this new material.

  7. Advances in HgCdTe APDs and LADAR Receivers

    NASA Technical Reports Server (NTRS)

    Bailey, Steven; McKeag, William; Wang, Jinxue; Jack, Michael; Amzajerdian, Farzin

    2010-01-01

    Raytheon is developing NIR sensor chip assemblies (SCAs) for scanning and staring 3D LADAR systems. High sensitivity is obtained by integrating high performance detectors with gain i.e. APDs with very low noise Readout Integrated Circuits. Unique aspects of these designs include: independent acquisition (non-gated) of pulse returns, multiple pulse returns with both time and intensity reported to enable full 3D reconstruction of the image. Recent breakthrough in device design has resulted in HgCdTe APDs operating at 300K with essentially no excess noise to gains in excess of 100, low NEP <1nW and GHz bandwidths and have demonstrated linear mode photon counting. SCAs utilizing these high performance APDs have been integrated and demonstrated excellent spatial and range resolution enabling detailed 3D imagery both at short range and long ranges. In this presentation we will review progress in high resolution scanning, staring and ultra-high sensitivity photon counting LADAR sensors.

  8. Compatibility of molten salts with advanced solar dynamic receiver materials

    NASA Technical Reports Server (NTRS)

    Jaworske, D. A.; Perry, W. D.

    1989-01-01

    Metal-coated graphite fibers are being considered as a thermal conductivity enhancement filler material for molten salts in solar dynamic thermal energy storage systems. The successful metal coating chosen for this application must exhibit acceptable wettability and must be compatible with the molten salt environment. Contact angle values between molten lithium fluoride and several metal, metal fluoride, and metal oxide substrates have been determined at 892 C using a modification of the Wilhelmy plate technique. Reproducible contact angles with repeated exposure to the molten LiF indicated compatibility.

  9. Thermal evaluation of advanced solar dynamic heat receiver performance

    NASA Technical Reports Server (NTRS)

    Crane, Roger A.

    1989-01-01

    The thermal performance of a variety of concepts for thermal energy storage as applied to solar dynamic applications is discussed. It is recognized that designs providing large thermal gradients or large temperature swings during orbit are susceptible to early mechanical failure. Concepts incorporating heat pipe technology may encounter operational limitations over sufficiently large ranges. By reviewing the thermal performance of basic designs, the relative merits of the basic concepts are compared. In addition the effect of thermal enhancement and metal utilization as applied to each design provides a partial characterization of the performance improvements to be achieved by developing these technologies.

  10. Support and maneuvering apparatus for solar energy receivers

    DOEpatents

    Murphy, L.M.

    1988-07-28

    A support and maneuvering apparatus is disclosed for a solar energy receiving device adapted for receiving and concentrating solar energy and having a central axis extending through the center thereof. The apparatus includes a frame for mounting the perimeter of said solar energy receiving device. A support member extends along the central axis of the receiving device and has a base end passing through the center of the receiving device and an outer distal end adapted for carrying a solar energy receiving and conversion mechanism. A variable tension mechanism interconnects the support member with the frame to provide stiffening for the support member and the frame and to assist in the alignment of the frame to optimize the optical efficiency of the solar energy receiving device. A rotatable base is provided, and connecting members extend from the base for pivotable attachment to the frame at spaced positions therealong. Finally, an elevation assembly is connected to the receiving device for selectively pivoting the receiving about an axis defined between the attachment positions of the connecting members on the frame. 4 figs.

  11. Support and maneuvering apparatus for solar energy receivers

    DOEpatents

    Murphy, Lawrence M.

    1989-01-01

    A support and maneuvering apparatus is disclosed for a solar energy receiving device adpated for receiving and concentrating solar energy and having a central axis extending through the center thereof. The apparatus includes a frame for mounting the perimeter of said solar energy receiving device. A support member extends along the central axis of the receiving device and has a base end passing through the center of the receiving device and an outer distal end adapted for carrying a solar energy receiving and conversion mechanism. A variable tension mechanism interconnects the support member with the frame to provide stiffening for the support member and the frame and to assist in the alignment of the frame to optimize the optical efficiency of the solar energy receiving device. A rotatable base is provided, and connecting members extend from the base for pivotable attachment to the frame at spaced positions therealong. Finally, an elevation assembly is connected to the receiving device for selectively pivoting the receiving device about an axis defined between the attachment positions of the connecting members on the frame.

  12. VLBI2010 Receiver Back End Comparison

    NASA Technical Reports Server (NTRS)

    Petrachenko, Bill

    2013-01-01

    VLBI2010 requires a receiver back-end to convert analog RF signals from the receiver front end into channelized digital data streams to be recorded or transmitted electronically. The back end functions are typically performed in two steps: conversion of analog RF inputs into IF bands (see Table 2), and conversion of IF bands into channelized digital data streams (see Tables 1a, 1b and 1c). The latter IF systems are now completely digital and generically referred to as digital back ends (DBEs). In Table 2 two RF conversion systems are compared, and in Tables 1a, 1b, and 1c nine DBE systems are compared. Since DBE designs are advancing rapidly, the data in these tables are only guaranteed to be current near the update date of this document.

  13. A large-scale points-of-dispensing exercise for first responders and first receivers in Nassau County, New York.

    PubMed

    Ablah, Elizabeth; Scanlon, Eileen; Konda, Kurt; Tinius, Annie; Gebbie, Kristine M

    2010-03-01

    Points of dispensing (PODs) are vital for responding to events that require mass chemoprophylaxis, such as bioterrorist attacks or pandemic influenza. This article evaluates the operational success of a large-scale dispensing drill for first responders and first receivers, focusing on differences in functioning of PODs by practice discipline and POD model. PODs were operated by either first responders (EMS, fire, or police) or first receivers (hospitals). Facilities could operate a centralized POD model, a decentralized POD model, or a combination, or "hybrid," model. Evaluation consisted of having evaluators at every POD, conducting a survey of POD individuals, and reviewing retrospectively the medications dispensed during the drill. Throughput counts, satisfaction with POD functioning, and errors in medication dispensing at each site are reported by practice discipline and facility model. During the drill, 23 PODs successfully processed more than 4,000 individuals. Centralized PODs and first responder facilities had faster throughput times than hybrid and hospital facilities, but hospital facilities had a lower incidence of medication error. Nominal differences in patient satisfaction were found. Assessing a combination of throughput, medical errors, and patient satisfaction with first responders and first receivers as points of dispensing can provide valuable insight into the feasibility of providing chemoprophylaxis to first responders and first receivers in advance of POD operations for the general public. PMID:20230230

  14. Low cost omega navigation receiver

    NASA Technical Reports Server (NTRS)

    Lilley, R. W.

    1974-01-01

    The development of a low cost Omega navigation receiver is discussed. Emphasis is placed on the completion and testing of a modular, multipurpose Omega receiver which utilizes a digital memory-aided, phase-locked loop to provide phase measurement data to a variety of applications interfaces. The functional units contained in the prototype device are described. The receiver is capable of receiving and storing phase measurements for up to eight Omega signals and computes two switch-selectable lines of position, displaying this navigation data in chart-recorded form.

  15. Receiver design and performance characteristics

    NASA Technical Reports Server (NTRS)

    Simon, M. K.; Yuen, J. H.

    1982-01-01

    The basic design, principles of operation, and characteristics of deep space communications receivers are examined. In particular, the basic fundamentals of phase-locked loop and Costas loop receivers used for synchronization, tracking, and demodulation of phase-coherent signals in residual carrier and suppressed carrier systems are addressed.

  16. Receiver design and performance characteristics

    NASA Astrophysics Data System (ADS)

    Simon, M. K.; Yuen, J. H.

    1982-07-01

    The basic design, principles of operation, and characteristics of deep space communications receivers are examined. In particular, the basic fundamentals of phase-locked loop and Costas loop receivers used for synchronization, tracking, and demodulation of phase-coherent signals in residual carrier and suppressed carrier systems are addressed.

  17. UWB delay and multiply receiver

    DOEpatents

    Dallum, Gregory E.; Pratt, Garth C.; Haugen, Peter C.; Romero, Carlos E.

    2013-09-10

    An ultra-wideband (UWB) delay and multiply receiver is formed of a receive antenna; a variable gain attenuator connected to the receive antenna; a signal splitter connected to the variable gain attenuator; a multiplier having one input connected to an undelayed signal from the signal splitter and another input connected to a delayed signal from the signal splitter, the delay between the splitter signals being equal to the spacing between pulses from a transmitter whose pulses are being received by the receive antenna; a peak detection circuit connected to the output of the multiplier and connected to the variable gain attenuator to control the variable gain attenuator to maintain a constant amplitude output from the multiplier; and a digital output circuit connected to the output of the multiplier.

  18. Noise Stability of SIS Receivers

    NASA Astrophysics Data System (ADS)

    Kooi, J. W.; Chattopadhyay, G.; Thielman, M.; Phillips, T. G.; Schieder, R.

    2000-05-01

    There is a strong interest in the submillimeter astronomy community to increase the IF bandwidth of SIS receivers in order to better facilitate broad spectral linewidth and continuum observations of extragalactic sources. However, with an increase in receiver IF bandwidth there is a decrease in the mixer stability. This in turn effects the integration efficiency and quality of the measurement. In order to better understand the noise mechanisms responsible for reducing the receiver stability, we employed a technique first described by D.W. Allan and later elaborated upon by Schieder et al. In this paper we address a variety of factors that degrade the noise stability of SIS receivers. The goal of this exercise is to make recommendations aimed at maximizing SIS receiver stability.

  19. Retiring the central executive.

    PubMed

    Logie, Robert H

    2016-10-01

    Reasoning, problem solving, comprehension, learning and retrieval, inhibition, switching, updating, or multitasking are often referred to as higher cognition, thought to require control processes or the use of a central executive. However, the concept of an executive controller begs the question of what is controlling the controller and so on, leading to an infinite hierarchy of executives or "homunculi". In what is now a QJEP citation classic, Baddeley [Baddeley, A. D. (1996). Exploring the central executive. Quarterly Journal of Experimental Psychology, 49A, 5-28] referred to the concept of a central executive in cognition as a "conceptual ragbag" that acted as a placeholder umbrella term for aspects of cognition that are complex, were poorly understood at the time, and most likely involve several different cognitive functions working in concert. He suggested that with systematic empirical research, advances in understanding might progress sufficiently to allow the executive concept to be "sacked". This article offers an overview of the 1996 article and of some subsequent systematic research and argues that after two decades of research, there is sufficient advance in understanding to suggest that executive control might arise from the interaction among multiple different functions in cognition that use different, but overlapping, brain networks. The article concludes that the central executive concept might now be offered a dignified retirement.

  20. Retiring the central executive.

    PubMed

    Logie, Robert H

    2016-10-01

    Reasoning, problem solving, comprehension, learning and retrieval, inhibition, switching, updating, or multitasking are often referred to as higher cognition, thought to require control processes or the use of a central executive. However, the concept of an executive controller begs the question of what is controlling the controller and so on, leading to an infinite hierarchy of executives or "homunculi". In what is now a QJEP citation classic, Baddeley [Baddeley, A. D. (1996). Exploring the central executive. Quarterly Journal of Experimental Psychology, 49A, 5-28] referred to the concept of a central executive in cognition as a "conceptual ragbag" that acted as a placeholder umbrella term for aspects of cognition that are complex, were poorly understood at the time, and most likely involve several different cognitive functions working in concert. He suggested that with systematic empirical research, advances in understanding might progress sufficiently to allow the executive concept to be "sacked". This article offers an overview of the 1996 article and of some subsequent systematic research and argues that after two decades of research, there is sufficient advance in understanding to suggest that executive control might arise from the interaction among multiple different functions in cognition that use different, but overlapping, brain networks. The article concludes that the central executive concept might now be offered a dignified retirement. PMID:26821744

  1. Interference-Detection Module in a Digital Radar Receiver

    NASA Technical Reports Server (NTRS)

    Fischman, Mark; Berkun, Andrew; Chu, Anhua; Freedman, Adam; Jourdan, Michael; McWatters, Dalia; Paller, Mimi

    2009-01-01

    A digital receiver in a 1.26-GHz spaceborne radar scatterometer now undergoing development includes a module for detecting radio-frequency interference (RFI) that could contaminate scientific data intended to be acquired by the scatterometer. The role of the RFI-detection module is to identify time intervals during which the received signal is likely to be contaminated by RFI and thereby to enable exclusion, from further scientific data processing, of signal data acquired during those intervals. The underlying concepts of detection of RFI and rejection of RFI-contaminated signal data are also potentially applicable in advanced terrestrial radio receivers, including software-defined radio receivers in general, receivers in cellular telephones and other wireless consumer electronic devices, and receivers in automotive collision-avoidance radar systems.

  2. Central line infections - hospitals

    MedlinePlus

    ... infection; CVC - infection; Central venous device - infection; Infection control - central line infection; Nosocomial infection - central line infection; Hospital acquired infection - central line infection; Patient safety - central ...

  3. Customizable Digital Receivers for Radar

    NASA Technical Reports Server (NTRS)

    Moller, Delwyn; Heavey, Brandon; Sadowy, Gregory

    2008-01-01

    Compact, highly customizable digital receivers are being developed for the system described in 'Radar Interferometer for Topographic Mapping of Glaciers and Ice Sheets' (NPO-43962), NASA Tech Briefs, Vol. 31, No. 7 (August 2007), page 72. The receivers are required to operate in unison, sampling radar returns received by the antenna elements in a digital beam-forming (DBF) mode. The design of these receivers could also be adapted to commercial radar systems. At the time of reporting the information for this article, there were no commercially available digital receivers capable of satisfying all of the operational requirements and compact enough to be mounted directly on the antenna elements. A provided figure depicts the overall system of which the digital receivers are parts. Each digital receiver includes an analog-to-digital converter (ADC), a demultiplexer (DMUX), and a field-programmable gate array (FPGA). The ADC effects 10-bit band-pass sampling of input signals having frequencies up to 3.5 GHz. The input samples are demultiplexed at a user-selectable rate of 1:2 or 1:4, then buffered in part of the FPGA that functions as a first-in/first-out (FIFO) memory. Another part of the FPGA serves as a controller for the ADC, DMUX, and FIFO memory and as an interface between (1) the rest of the receiver and (2) a front-panel data port (FPDP) bus, which is an industry-standard parallel data bus that has a high data-rate capability and multichannel configuration suitable for DBF. Still other parts of the FPGA in each receiver perform signal-processing functions. The digital receivers can be configured to operate in a stand-alone mode, or in a multichannel mode as needed for DBF. The customizability of the receiver makes it applicable to a broad range of system architectures. The capability for operation of receivers in either a stand-alone or a DBF mode enables the use of the receivers in an unprecedentedly wide variety of radar systems.

  4. Sensitivity of terahertz photonic receivers

    NASA Astrophysics Data System (ADS)

    Matsko, A. B.; Strekalov, D. V.; Yu, N.

    2008-04-01

    We theoretically discuss sensitivity limitations of a THz receiver which is based on up-conversion of the THz radiation into optical domain using high quality factor crystalline whispering gallery mode resonators. We show that the sensitivity of the receiver operating in the nonlinear regime approaches the sensitivity of an ideal THz photon counter. Thermal noise of the counter can be substantially reduced because of transparency of the nonlinear material in the THz frequency range. We also show that the density of power fluctuations of the receiver operating in the linear regime is given by the THz shot noise.

  5. Coe Receives 2007 Gilbert Award

    NASA Astrophysics Data System (ADS)

    Bogue, Scott W.; Coe, Robert S.

    2008-05-01

    Robert S. Coe received the 2007 William Gilbert Award at the 2007 AGU Fall Meeting in San Francisco, Calif. The award recognizes outstanding and unselfish work in magnetism of Earth materials and of the Earth and planets.

  6. Stevenson received the Whipple award

    NASA Astrophysics Data System (ADS)

    Shoemaker, Eugene M.; Stevenson, David J.

    1996-02-01

    David J. Stevenson received the Whipple Award at the 1994 Spring Meeting in Baltimore. The award is given for outstanding scientific contributions to the field of planetology. The citation and Stevenson's response are given here.

  7. Streak camera receiver definition study

    NASA Technical Reports Server (NTRS)

    Johnson, C. B.; Hunkler, L. T., Sr.; Letzring, S. A.; Jaanimagi, P.

    1990-01-01

    Detailed streak camera definition studies were made as a first step toward full flight qualification of a dual channel picosecond resolution streak camera receiver for the Geoscience Laser Altimeter and Ranging System (GLRS). The streak camera receiver requirements are discussed as they pertain specifically to the GLRS system, and estimates of the characteristics of the streak camera are given, based upon existing and near-term technological capabilities. Important problem areas are highlighted, and possible corresponding solutions are discussed.

  8. Solar dynamic heat receiver technology

    NASA Technical Reports Server (NTRS)

    Sedgwick, Leigh M.

    1991-01-01

    A full-size, solar dynamic heat receiver was designed to meet the requirements specified for electrical power modules on the U.S. Space Station, Freedom. The heat receiver supplies thermal energy to power a heat engine in a closed Brayton cycle using a mixture of helium-xenon gas as the working fluid. The electrical power output of the engine, 25 kW, requires a 100 kW thermal input throughout a 90 minute orbit, including when the spacecraft is eclipsed for up to 36 minutes from the sun. The heat receiver employs an integral thermal energy storage system utilizing the latent heat available through the phase change of a high-temperature salt mixture. A near eutectic mixture of lithium fluoride and calcium difluoride is used as the phase change material. The salt is contained within a felt metal matrix which enhances heat transfer and controls the salt void distribution during solidification. Fabrication of the receiver is complete and it was delivered to NASA for verification testing in a simulated low-Earth-orbit environment. This document reviews the receiver design and describes its fabrication history. The major elements required to operate the receiver during testing are also described.

  9. Integrated solar upper stage alternate receiver

    SciTech Connect

    Streckert, H.H.; Begg, L.L.; Heffernan, T.F.; Horner, M.H.

    1997-12-31

    The Integrated Solar Upper Stage (ISUS) receiver is a compact orbital transfer vehicle designed to generate thrust to boost transfer payloads from low earth orbit to Molniya or geosynchronous orbits. It can provide thrust by collecting and concentrating solar flux and heating hydrogen to {approximately} 2,500 K. Simultaneously, the ISUS receiver radiates heat into an array of thermionic converters to produce electrical power. The central component consists of a graphite body with rhenium lined internal passages. The alternate receiver relies on wrought rhenium that is rolled, machined and electron-beam welded to form a complex rhenium liner system within the graphite body. All machining operations were performed by molybdenum wire electron discharge machining. The tube forming procedure was performed to minimize the amount of cold work before annealing. Electron-beam welding was performed at a current density range of {approximately} 2 to 10 A/cm{sup 2} depending on material thickness, which melts the rhenium locally and results in a fine grained weld zone. A simplified Demonstration Test Assembly was fabricated and tested. The unit consisted of an inlet structure welded to a manifold with a simplified exhaust nozzle system and contained in a machined graphite body. The external graphite surfaces were coated with plasma sprayed rhenium for protection from graphite erosion. Testing included a hot hydrogen flow test to {approximately} 2,500 K. The main ISUS Alternate Receiver was designed and built according to the same procedures as the demonstration unit. However, the inlet and outlet plenums are more complex and are connected by 195 channels to efficiently transfer heat to the flowing hydrogen. An outlet tube containing a sonic orifice mates to the exhaust plenum.

  10. Robust quantum receivers for coherent state discrimination

    NASA Astrophysics Data System (ADS)

    Becerra, Francisco Elohim

    2014-05-01

    Quantum state discrimination is a central task for quantum information and is a fundamental problem in quantum mechanics. Nonorthogonal states, such as coherent states which have intrinsic quantum noise, cannot be discriminated with total certainty because of their intrinsic overlap. This nonorthogonality is at the heart of quantum key distribution for ensuring absolute secure communications between a transmitter and a receiver, and can enable many quantum information protocols based on coherent states. At the same time, while coherent states are used for communications because of their robustness to loss and simplicity of generation and detection, their nonorthogonality inherently produces errors in the process of decoding the information. The minimum error probability in the discrimination of nonorthogonal coherent states measured by an ideal lossless and noiseless conventional receiver is given by the standard quantum limit (SQL). This limit sets strict bounds on the ultimate performance of coherent communications and many coherent-state-based quantum information protocols. However, measurement strategies based on the quantum properties of these states can allow for better measurements that surpass the SQL and approach the ultimate measurement limits allowed by quantum mechanics. These measurement strategies can allow for optimally extracting information encoded in these states for coherent and quantum communications. We present the demonstration of a receiver based on adaptive measurements and single-photon counting that unconditionally discriminates multiple nonorthogonal coherent states below the SQL. We also discuss the potential of photon-number-resolving detection to provide robustness and high sensitivity under realistic conditions for an adaptive coherent receiver with detectors with finite photon-number resolution.

  11. Epidermal Growth Factor Receptor Mutation-Positive Non-Small-Cell Lung Cancer in the Real-World Setting in Central Europe: The INSIGHT Study.

    PubMed

    Ramlau, Rodryg; Cufer, Tanja; Berzinec, Peter; Dziadziuszko, Rafal; Olszewski, Włodzimierz; Popper, Helmut; Bajcic, Paolo; Dušek, Ladislav; Zbozinkova, Zuzana; Pirker, Robert

    2015-09-01

    The ImplementatioN of perSonalized medicine In NSCLC in Central Europe: EGFR testing, Histopathology, and clinical feaTures (INSIGHT) observational study assessed both implementation of epidermal growth factor receptor (EGFR) mutation testing and treatment of patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC) in a real-world setting in Central Europe. A total of 1785 patients from 14 cancer centers of six Central European countries were enrolled. EGFR mutations were detected in tumors of 13.8% of the patients. More than 70% of patients with advanced EGFR mutation-positive NSCLC received EGFR tyrosine kinase inhibitors as first-line therapy. The INSIGHT study demonstrated the establishment of EGFR mutation testing, a mutation rate consistent with other Caucasian patients populations, and adherence to current guidelines regarding treatment of patients with EGFR mutation-positive tumors in Central Europe.

  12. 18 CFR 367.1420 - Account 142, Customer accounts receivable.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Account 142, Customer accounts receivable. 367.1420 Section 367.1420 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  13. 18 CFR 367.1430 - Account 143, Other accounts receivable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Account 143, Other accounts receivable. 367.1430 Section 367.1430 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  14. 18 CFR 367.1430 - Account 143, Other accounts receivable.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Account 143, Other accounts receivable. 367.1430 Section 367.1430 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  15. 18 CFR 367.1420 - Account 142, Customer accounts receivable.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Account 142, Customer accounts receivable. 367.1420 Section 367.1420 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  16. 18 CFR 367.1430 - Account 143, Other accounts receivable.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Account 143, Other accounts receivable. 367.1430 Section 367.1430 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  17. 18 CFR 367.1420 - Account 142, Customer accounts receivable.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Account 142, Customer accounts receivable. 367.1420 Section 367.1420 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  18. 18 CFR 367.1420 - Account 142, Customer accounts receivable.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Account 142, Customer accounts receivable. 367.1420 Section 367.1420 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  19. 18 CFR 367.1430 - Account 143, Other accounts receivable.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Account 143, Other accounts receivable. 367.1430 Section 367.1430 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  20. 18 CFR 367.1430 - Account 143, Other accounts receivable.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Account 143, Other accounts receivable. 367.1430 Section 367.1430 Conservation of Power and Water Resources FEDERAL ENERGY..., FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES...

  1. 18 CFR 367.1720 - Account 172, Rents receivable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT TO THE PROVISIONS OF THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS... service company to others. (b) Rents receivable from associate companies must be included in account...

  2. 18 CFR 367.1410 - Account 141, Notes receivable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE COMPANIES SUBJECT TO THE PROVISIONS OF THE PUBLIC UTILITY HOLDING COMPANY ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS... demand or within one year from the date of issue, except, however, notes receivable from...

  3. LDORA: a novel laser communications receiver array architecture

    NASA Astrophysics Data System (ADS)

    Boroson, Don M.; Bondurant, Roy S.; Murphy, Daniel V.

    2004-06-01

    We present a new laser communications receiver architecture. It consists of an array of individually mounted telescopes, each with a Geiger-mode photon counting detector array. The detector outputs are sent to a central processor using standard digital networking hardware. The concept has many benefits including low cost and scalability.

  4. Advanced solar concentrator development in the United States

    SciTech Connect

    Alpert, D.J.

    1990-01-01

    Sandia National Laboratories is the lead laboratory for the United States Department of Energy's program to develop, build, and test advanced solar concentrators that are low in cost, have high performance, and demonstrate a long lifetime. The principal focus of DOE's concentrator program is on the development of heliostats for central receiver power plants and point focus parabolic dishes for use with a 25-kWe Stirling engine. The status and future plans of DOE's program in each area are reviewed. 29 refs., 7 figs.

  5. UWB communication receiver feedback loop

    DOEpatents

    Spiridon, Alex; Benzel, Dave; Dowla, Farid U.; Nekoogar, Faranak; Rosenbury, Erwin T.

    2007-12-04

    A novel technique and structure that maximizes the extraction of information from reference pulses for UWB-TR receivers is introduced. The scheme efficiently processes an incoming signal to suppress different types of UWB as well as non-UWB interference prior to signal detection. Such a method and system adds a feedback loop mechanism to enhance the signal-to-noise ratio of reference pulses in a conventional TR receiver. Moreover, sampling the second order statistical function such as, for example, the autocorrelation function (ACF) of the received signal and matching it to the ACF samples of the original pulses for each transmitted bit provides a more robust UWB communications method and system in the presence of channel distortions.

  6. Central mechanisms II: pharmacology of brainstem pathways.

    PubMed

    Bolser, D C

    2009-01-01

    Following systemic administration, centrally acting antitussive drugs are generally assumed to act in the brainstem to inhibit cough. However, recent work in humans has raised the possibility of suprapontine sites of action for cough suppressants. For drugs that may act in the brainstem, the specific locations, types of neurones affected, and receptor specificities of the compounds represent important issues regarding their cough-suppressant actions. Two medullary areas that have received the most attention regarding the actions of antitussive drugs are the nucleus of the tractus solitarius (NTS) and the caudal ventrolateral respiratory column. Studies that have implicated these two medullary areas have employed both microinjection and in vitro recording methods to control the location of action of the antitussive drugs. Other brainstem regions contain neurones that participate in the production of cough and could represent potential sites of action of antitussive drugs. These regions include the raphe nuclei, pontine nuclei, and rostral ventrolateral medulla. Specific receptor subtypes have been associated with the suppression of cough at central sites, including 5-HT1A, opioid (mu, kappa, and delta), GABA-B, tachykinin neurokinin-1 (NK-1) and neurokinin-2, non-opioid (NOP-1), cannabinoid, dopaminergic, and sigma receptors. Aside from tachykinin NK-1 receptors in the NTS, relatively little is known regarding the receptor specificity of putative antitussive drugs in particular brainstem regions. Our understanding of the mechanisms of action of antitussive drugs would be significantly advanced by further work in this area. PMID:18825342

  7. Receiver for digital radio broadcasting via satellite

    NASA Astrophysics Data System (ADS)

    Degraaf, C. R.

    1984-10-01

    Quadrature Phase Shift Keying (QPSK) demodulators were investigated; a differential-coherent demodulator (with delay-line) for a 20.48 Mbit/sec and 118 MHz medium frequency was developed. A modified professional coherent demodulator (With Costas-loop carrier wave regaining) (CD), was compared with the DQPSK. At the cost of higher circuit complexity and more adjustings, the CD shows better performances; both demodulators show deviation values 2dB. Applied bit error detection and correction methods were investigated and decoding tables were developed. In cases of high system reserves (e.g., central antenna installations of TV-receiver installations) the cheaper DQPSK is recommended. A prefabricated delay-line (and medium frequency filter) in surface acoustic wave technique is recommended to avoid complicated adjusting procedures.

  8. Organic Rankine cycle receiver development

    NASA Technical Reports Server (NTRS)

    Haskins, H. J.

    1981-01-01

    The selected receiver concept is a direct-heated, once-through, monotube boiler operated at supercritical pressure. The cavity is formed by a cylindrical copper shell and backwall, with stainless steel tubing brazed to the outside surface. This core is surrounded by lightweight refractory insulation, load-bearing struts, and an outer case. The aperture plate is made of copper to provide long life by conduction and reradiation of heat away from the aperture lip. The receiver thermal efficiency is estimated to be 97 percent at rated conditions (energy transferred to toluene divided by energy incident on aperture opening). Development of the core manufacturing and corrosion protection methods is complete.

  9. The GBT 4mm Receiver

    NASA Astrophysics Data System (ADS)

    Frayer, David T.; White, S.; Watts, G.; Stennes, M.; Maddalena, R. J.; Simon, R.; Pospieszalski, M.; Bryerton, E.

    2013-01-01

    The new 4mm receiver (67--93 GHz) for the Robert C. Byrd Green Bank Telescope (GBT) was built to take advantage of the improved surface accuracy of the dish. The low frequency end of the 3mm atmospheric window is not available with ALMA (<84 GHz), and the sensitivity of the GBT is better than any other facility within this band. We discuss the design and performance of this new receiver for the GBT, and highlight the science opportunities available with the instrument. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.

  10. Perron receives 2011 Luna B. Leopold Young Scientist Award: Response

    NASA Astrophysics Data System (ADS)

    Perron, J. Taylor

    2012-06-01

    J. Taylor Perron received the 2011 Luna B. Leopold Young Scientist Award at the 2011 AGU Fall Meeting, held 5-9 December in San Francisco, Calif. The award recognizes "a young scientist for making a significant and outstanding contribution that advances the field of Earth and planetary surface processes."

  11. Perron receives 2011 Luna B. Leopold Young Scientist Award: Citation

    NASA Astrophysics Data System (ADS)

    Howard, Alan D.

    2012-06-01

    J. Taylor Perron received the 2011 Luna B. Leopold Young Scientist Award at the 2011 AGU Fall Meeting, held 5-9 December in San Francisco, Calif. The award recognizes "a young scientist for making a significant and outstanding contribution that advances the field of Earth and planetary surface processes."

  12. Jerolmack receives 2010 Luna B. Leopold Young Scientist Award: Citation

    NASA Astrophysics Data System (ADS)

    Mohrig, David C.

    2011-06-01

    Douglas J. Jerolmack received the 2010 Luna B. Leopold Young Scientist Award at the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. The award recognizes “a young scientist for making a significant and outstanding contribution that advances the field of Earth and planetary surface processes.”

  13. Lamb Receives 2012 Luna B. Leopold Young Scientist Award: Citation

    NASA Astrophysics Data System (ADS)

    Myrow, Paul

    2013-09-01

    Michael Lamb received the 2012 Luna B. Leopold Young Scientist Award at the 2012 AGU Fall Meeting, held 3-7 December in San Francisco, Calif. The award recognizes "a young scientist for making a significant and outstanding contribution that advances the field of Earth and planetary surface processes."

  14. Jerolmack receives 2010 Luna B. Leopold Young Scientist Award: Response

    NASA Astrophysics Data System (ADS)

    Jerolmack, Douglas J.

    2011-06-01

    Douglas J. Jerolmack received the 2010 Luna B. Leopold Young Scientist Award at the 2010 AGU Fall Meeting, held 13“17 December in San Francisco, Calif. The award recognizes “a young scientist for making a significant and outstanding contribution that advances the field of Earth and planetary surface processes.”

  15. Ceramic technology for solar thermal receivers

    NASA Technical Reports Server (NTRS)

    Kudirka, A. A.; Smoak, R. H.

    1981-01-01

    The high-temperature capability, resistance to corrosive environments and non-strategic nature of ceramics have prompted applications in the solar thermal field whose advantages over metallic devices of comparable performance may begin to be assessed. It is shown by a survey of point-focusing receiver designs employing a variety of ceramic compositions and fabrication methods that the state-of-the-art in structural ceramics is not sufficiently advanced to fully realize the promised benefits of higher temperature capabilities at lower cost than metallic alternatives. The ceramics considered include alumina, berylia, magnesia, stabilized zirconia, fused silica, silicon nitride, silicon carbide, mullite and cordierite, processed by such methods as isostatic pressing, dry pressing, slip casting, extrusion, calendaring and injection molding.

  16. Morel Receives 2005 Maurice Ewing Medal

    NASA Astrophysics Data System (ADS)

    Schrag, Daniel P.; Morel, François M. M.

    2006-02-01

    François M. M. Morel received the Ewing Medal at the AGU Fall Meeting Honors Ceremony, which was held on 7 December 2005, in San Francisco, Calif. The medal is given for significant original contributions to the scientific understanding of the processes in the ocean; for the advancement of oceanographic engineering, technology, and instrumentation; and for outstanding service to marine sciences. François Morel has led the search to understand the role of metals in the ocean, starting with a focus on inorganic processes and aquatic chemistry, and leading to a blend of geochemistry, microbiology, biochemistry, and genetics. His influence comes from his research and from the way he has educated an entire community of scientists with his textbooks, with his teaching, and through his former students and postdocs who hold faculty positions at universities throughout the world.

  17. Uncooled receivers for CO2 laser radiation

    NASA Astrophysics Data System (ADS)

    Granovskii, A. B.; Iakovlev, V. A.

    1986-01-01

    Published data on low-inertia, uncooled, single-element and matrix-type radiation receivers that have a high degree of reliability and are immune from interference from various external sources are systematically summarized. Three basic types of receivers are examined: photonic receivers, thermal receivers, and receivers based on wave interaction. Principal attention is given to the CO2 laser radiation receiver.

  18. STAR: SOFIA terahertz array receiver

    NASA Astrophysics Data System (ADS)

    Graf, Urs U.; Heyminck, Stefan; Rabanus, D.; Jacobs, Karl; Schieder, Rudolf T.; Stutzki, Juergen

    2003-02-01

    We present the concept for KOSMA's 16 element 1.9 THz heterodyne array STAR (SOFIA Terahertz Array Receiver) which is being developed for SOFIA. The instrument will consist of two interleaved sub-arrays of 8 pixels each. Together we will have a 4 × 4 pixel array with a beam spacing on the sky of approximately 1.5 times the beam size of 15 arcsec (FWHM). The receiver is mainly targeted at measuring the fine structure transition of ionized atomic carbon at 1.9 THz (158 microns). STAR's optics setup is modeled after the successful design used in KOSMA's SMART receiver. It will contain a K-mirror type beam rotator, a Martin-Puplett diplexer for LO coupling and an LO multiplexer using imaging Fourier gratings. Complete optical sub-assemblies will be machined monolithically as integrated optics units, to reduce the need for optical alignment. STAR will probably use waveguide mixers with diffusion cooled hot electron bolometers, which are being developed at KOSMA. The receiver backends will be KOSMA Array-AOSs. Local oscillator power will be provided by a backward wave oscillator (BWO), followed by a frequency tripler.

  19. Microwave blackbodies for spaceborne receivers

    NASA Technical Reports Server (NTRS)

    Stacey, J. M.

    1985-01-01

    The properties of microwave blackbody targets are explained as they apply to the calibration of spaceborne receivers. Also described are several practicable, blackbody targets used to test and calibrate receivers in the laboratory and in the thermal vacuum chamber. Problems with the precision and the accuracy of blackbody targets, and blackbody target design concepts that overcome some of the accuracy limitations present in existing target designs, are presented. The principle of the Brewster angle blackbody target is described where the blackbody is applied as a fixed-temperature test target in the laboratory and as a variable-temperature target in the thermal vacuum chamber. The reflectivity of a Brewster angle target is measured in the laboratory. From this measurement, the emissivity of the target is calculated. Radiatively cooled thermal suspensions are discussed as the coolants of blackbody targets and waveguide terminations that function as calibration devices in spaceborne receivers. Examples are given for the design of radiatively cooled thermal suspensions. Corrugated-horn antennas used to observe the cosmic background and to provide a cold-calibration source for spaceborne receivers are described.

  20. Clark Receives Ocean Sciences Award

    NASA Astrophysics Data System (ADS)

    Roman, Michael R.; Clark, H. Lawrence

    2008-09-01

    H. Lawrence Clark received the 2008 Ocean Sciences Award at the 2008 Ocean Sciences Meeting, held 2-7 March 2008 in Orlando, Fla. The award is given in recognition of outstanding and long-standing service to the ocean sciences.

  1. RFID receiver apparatus and method

    DOEpatents

    Scott, Jeffrey Wayne

    2006-12-26

    An RFID backscatter interrogator for transmitting data to an RFID tag, generating a carrier for the tag, and receiving data from the tag modulated onto the carrier, the interrogator including a single grounded-coplanar wave-guide circuit board and at least one surface mount integrated circuit supported by the circuit board.

  2. Vergano Receives David Perlman Award

    NASA Astrophysics Data System (ADS)

    Kelly, Sue

    2006-08-01

    Dan Vergano received the Perlman Award at the Joint Assembly Honors Ceremony, whichwas held on 25 May 2006 in Baltimore, Md. Vergano was honored for `The Debate's over:Globe is warming,' which describes the linkages between the science of climate change andthe complexity of technical and economic decisions facing its mitigation.

  3. Receivers for modulated digital signals

    NASA Astrophysics Data System (ADS)

    Troendle, K.; Huber, J.

    The realization principles for coherent and incoherent receivers for modulated digital signal transmission are presented. From these principles, the digital amplitude, phase, and frequency modulation are treated. Expressions for the error probabilities in these systems are given, and their required bandwidths and noise sensitivities are compared. Principles of system realization for time-variant channels and methods of clock and carrier recovery are explained.

  4. VIEW OF CENTRAL INTERIOR SPACE, FACING NORTHEAST. Douglas Aircraft ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF CENTRAL INTERIOR SPACE, FACING NORTHEAST. - Douglas Aircraft Company Long Beach Plant, Aircraft Parts Shipping & Receiving Building, 3855 Lakewood Boulevard, Long Beach, Los Angeles County, CA

  5. Advancing toward Shared Decision Making

    ERIC Educational Resources Information Center

    Muller, Lisa; Thorn, Judi

    2007-01-01

    In May 2004, a group of 25 teachers at Jenks High School in Oklahoma received an invitation to the Summer 2004 Advance. Although many organizations hold retreats for their employees, the administrators wanted to send a different message: we're not retreating; we're advancing! Like many states, Oklahoma suffered a school budget crisis during the…

  6. Silicon central pattern generators for cardiac diseases.

    PubMed

    Nogaret, Alain; O'Callaghan, Erin L; Lataro, Renata M; Salgado, Helio C; Meliza, C Daniel; Duncan, Edward; Abarbanel, Henry D I; Paton, Julian F R

    2015-02-15

    Cardiac rhythm management devices provide therapies for both arrhythmias and resynchronisation but not heart failure, which affects millions of patients worldwide. This paper reviews recent advances in biophysics and mathematical engineering that provide a novel technological platform for addressing heart disease and enabling beat-to-beat adaptation of cardiac pacing in response to physiological feedback. The technology consists of silicon hardware central pattern generators (hCPGs) that may be trained to emulate accurately the dynamical response of biological central pattern generators (bCPGs). We discuss the limitations of present CPGs and appraise the advantages of analog over digital circuits for application in bioelectronic medicine. To test the system, we have focused on the cardio-respiratory oscillators in the medulla oblongata that modulate heart rate in phase with respiration to induce respiratory sinus arrhythmia (RSA). We describe here a novel, scalable hCPG comprising physiologically realistic (Hodgkin-Huxley type) neurones and synapses. Our hCPG comprises two neurones that antagonise each other to provide rhythmic motor drive to the vagus nerve to slow the heart. We show how recent advances in modelling allow the motor output to adapt to physiological feedback such as respiration. In rats, we report on the restoration of RSA using an hCPG that receives diaphragmatic electromyography input and use it to stimulate the vagus nerve at specific time points of the respiratory cycle to slow the heart rate. We have validated the adaptation of stimulation to alterations in respiratory rate. We demonstrate that the hCPG is tuneable in terms of the depth and timing of the RSA relative to respiratory phase. These pioneering studies will now permit an analysis of the physiological role of RSA as well as its any potential therapeutic use in cardiac disease. PMID:25433077

  7. Silicon central pattern generators for cardiac diseases

    PubMed Central

    Nogaret, Alain; O'Callaghan, Erin L; Lataro, Renata M; Salgado, Helio C; Meliza, C Daniel; Duncan, Edward; Abarbanel, Henry D I; Paton, Julian F R

    2015-01-01

    Cardiac rhythm management devices provide therapies for both arrhythmias and resynchronisation but not heart failure, which affects millions of patients worldwide. This paper reviews recent advances in biophysics and mathematical engineering that provide a novel technological platform for addressing heart disease and enabling beat-to-beat adaptation of cardiac pacing in response to physiological feedback. The technology consists of silicon hardware central pattern generators (hCPGs) that may be trained to emulate accurately the dynamical response of biological central pattern generators (bCPGs). We discuss the limitations of present CPGs and appraise the advantages of analog over digital circuits for application in bioelectronic medicine. To test the system, we have focused on the cardio-respiratory oscillators in the medulla oblongata that modulate heart rate in phase with respiration to induce respiratory sinus arrhythmia (RSA). We describe here a novel, scalable hCPG comprising physiologically realistic (Hodgkin–Huxley type) neurones and synapses. Our hCPG comprises two neurones that antagonise each other to provide rhythmic motor drive to the vagus nerve to slow the heart. We show how recent advances in modelling allow the motor output to adapt to physiological feedback such as respiration. In rats, we report on the restoration of RSA using an hCPG that receives diaphragmatic electromyography input and use it to stimulate the vagus nerve at specific time points of the respiratory cycle to slow the heart rate. We have validated the adaptation of stimulation to alterations in respiratory rate. We demonstrate that the hCPG is tuneable in terms of the depth and timing of the RSA relative to respiratory phase. These pioneering studies will now permit an analysis of the physiological role of RSA as well as its any potential therapeutic use in cardiac disease. PMID:25433077

  8. A digital-receiver for the MurchisonWidefield Array

    NASA Astrophysics Data System (ADS)

    Prabu, Thiagaraj; Srivani, K. S.; Roshi, D. Anish; Kamini, P. A.; Madhavi, S.; Emrich, David; Crosse, Brian; Williams, Andrew J.; Waterson, Mark; Deshpande, Avinash A.; Shankar, N. Udaya; Subrahmanyan, Ravi; Briggs, Frank H.; Goeke, Robert F.; Tingay, Steven J.; Johnston-Hollitt, Melanie; R, Gopalakrishna M.; Morgan, Edward H.; Pathikulangara, Joseph; Bunton, John D.; Hampson, Grant; Williams, Christopher; Ord, Stephen M.; Wayth, Randall B.; Kumar, Deepak; Morales, Miguel F.; deSouza, Ludi; Kratzenberg, Eric; Pallot, D.; McWhirter, Russell; Hazelton, Bryna J.; Arcus, Wayne; Barnes, David G.; Bernardi, Gianni; Booler, T.; Bowman, Judd D.; Cappallo, Roger J.; Corey, Brian E.; Greenhill, Lincoln J.; Herne, David; Hewitt, Jacqueline N.; Kaplan, David L.; Kasper, Justin C.; Kincaid, Barton B.; Koenig, Ronald; Lonsdale, Colin J.; Lynch, Mervyn J.; Mitchell, Daniel A.; Oberoi, Divya; Remillard, Ronald A.; Rogers, Alan E.; Salah, Joseph E.; Sault, Robert J.; Stevens, Jamie B.; Tremblay, S.; Webster, Rachel L.; Whitney, Alan R.; Wyithe, Stuart B.

    2015-03-01

    An FPGA-based digital-receiver has been developed for a low-frequency imaging radio interferometer, the Murchison Widefield Array (MWA). The MWA, located at the Murchison Radio-astronomy Observatory (MRO) in Western Australia, consists of 128 dual-polarized aperture-array elements (tiles) operating between 80 and 300 MHz, with a total processed bandwidth of 30.72 MHz for each polarization. Radio-frequency signals from the tiles are amplified and band limited using analog signal conditioning units; sampled and channelized by digital-receivers. The signals from eight tiles are processed by a single digital-receiver, thus requiring 16 digital-receivers for the MWA. The main function of the digital-receivers is to digitize the broad-band signals from each tile, channelize them to form the sky-band, and transport it through optical fibers to a centrally located correlator for further processing. The digital-receiver firmware also implements functions to measure the signal power, perform power equalization across the band, detect interference-like events, and invoke diagnostic modes. The digital-receiver is controlled by high-level programs running on a single-board-computer. This paper presents the digital-receiver design, implementation, current status, and plans for future enhancements.

  9. ICESat-2 / ATLAS Flight Science Receiver Algorithms

    NASA Astrophysics Data System (ADS)

    Mcgarry, J.; Carabajal, C. C.; Degnan, J. J.; Mallama, A.; Palm, S. P.; Ricklefs, R.; Saba, J. L.

    2013-12-01

    NASA's Advanced Topographic Laser Altimeter System (ATLAS) will be the single instrument on the ICESat-2 spacecraft which is expected to launch in 2016 with a 3 year mission lifetime. The ICESat-2 orbital altitude will be 500 km with a 92 degree inclination and 91-day repeat tracks. ATLAS is a single photon detection system transmitting at 532nm with a laser repetition rate of 10 kHz and a 6 spot pattern on the Earth's surface. Without some method of eliminating solar background noise in near real-time, the volume of ATLAS telemetry would far exceed the normal X-band downlink capability. To reduce the data volume to an acceptable level a set of onboard Receiver Algorithms has been developed. These Algorithms limit the daily data volume by distinguishing surface echoes from the background noise and allow the instrument to telemeter only a small vertical region about the signal. This is accomplished through the use of an onboard Digital Elevation Model (DEM), signal processing techniques, and an onboard relief map. Similar to what was flown on the ATLAS predecessor GLAS (Geoscience Laser Altimeter System) the DEM provides minimum and maximum heights for each 1 degree x 1 degree tile on the Earth. This information allows the onboard algorithm to limit its signal search to the region between minimum and maximum heights (plus some margin for errors). The understanding that the surface echoes will tend to clump while noise will be randomly distributed led us to histogram the received event times. The selection of the signal locations is based on those histogram bins with statistically significant counts. Once the signal location has been established the onboard Digital Relief Map (DRM) is used to determine the vertical width of the telemetry band about the signal. The ATLAS Receiver Algorithms are nearing completion of the development phase and are currently being tested using a Monte Carlo Software Simulator that models the instrument, the orbit and the environment

  10. Carboplatin pharmacokinetics in a patient receiving hemodialysis.

    PubMed

    Fong, Mei Ka; Fetterly, Gerald J; McDougald, Lori J; Iyer, Renuka V

    2014-02-01

    With refinements and advances in hemodialysis techniques, survival for patients with end-stage renal disease has improved significantly. To our knowledge, however, no prospective trials have been performed in patients receiving hemodialysis who are also diagnosed with cancer and are candidates for chemotherapy. We describe a 73-year-old man who was diagnosed with high-grade neuroendocrine carcinoma, metastatic to the bone and lymph nodes, and was undergoing hemodialysis. Although cisplatin is more commonly used in the treatment of metastatic neuroendocrine cancers, it may not be the best option in patients who suffer from renal insufficiency. Carboplatin is a second-generation, nonnephrotoxic platinum analog that can be hemodialyzed, although no formal guidelines are available regarding the dosing for patients receiving hemodialysis. This case describes a patient who was treated with five cycles of combination carboplatin 115 mg/m(2) on day 1 and etoposide 50 mg/m(2) on day 1 and day 3 of a 28-day cycle. Dialysis was performed for 3.5 hours starting 90 minutes after completion of carboplatin on day 1. Pharmacokinetic assessments were performed at 1, 2, 4, and 12 hours after chemotherapy infusion on day 1 of cycle 1. Total carboplatin concentrations in plasma and platinum ultrafiltrate were measured. The plasma concentration of free platinum at the end of the infusion was 31,000 ng/ml, and the area under the plasma concentration-time curve was 2.9 minute·mg/ml. No significant carboplatin-related toxicities were reported. This case report indicates that carboplatin can be safely administered in patients receiving hemodialysis.

  11. Advances in Human B Cell Phenotypic Profiling

    PubMed Central

    Kaminski, Denise A.; Wei, Chungwen; Qian, Yu; Rosenberg, Alexander F.; Sanz, Ignacio

    2012-01-01

    To advance our understanding and treatment of disease, research immunologists have been called-upon to place more centralized emphasis on impactful human studies. Such endeavors will inevitably require large-scale study execution and data management regulation (“Big Biology”), necessitating standardized and reliable metrics of immune status and function. A well-known example setting this large-scale effort in-motion is identifying correlations between eventual disease outcome and T lymphocyte phenotype in large HIV-patient cohorts using multiparameter flow cytometry. However, infection, immunodeficiency, and autoimmunity are also characterized by correlative and functional contributions of B lymphocytes, which to-date have received much less attention in the human Big Biology enterprise. Here, we review progress in human B cell phenotyping, analysis, and bioinformatics tools that constitute valuable resources for the B cell research community to effectively join in this effort. PMID:23087687

  12. Scintillation-Hardened GPS Receiver

    NASA Technical Reports Server (NTRS)

    Stephens, Donald R.

    2015-01-01

    CommLargo, Inc., has developed a scintillation-hardened Global Positioning System (GPS) receiver that improves reliability for low-orbit missions and complies with NASA's Space Telecommunications Radio System (STRS) architecture standards. A software-defined radio (SDR) implementation allows a single hardware element to function as either a conventional radio or as a GPS receiver, providing backup and redundancy for platforms such as the International Space Station (ISS) and high-value remote sensing platforms. The innovation's flexible SDR implementation reduces cost, weight, and power requirements. Scintillation hardening improves mission reliability and variability. In Phase I, CommLargo refactored an open-source GPS software package with Kalman filter-based tracking loops to improve performance during scintillation and also demonstrated improved navigation during a geomagnetic storm. In Phase II, the company generated a new field-programmable gate array (FPGA)-based GPS waveform to demonstrate on NASA's Space Communication and Navigation (SCaN) test bed.

  13. Femtosecond Photon-Counting Receiver

    NASA Technical Reports Server (NTRS)

    Krainak, Michael A.; Rambo, Timothy M.; Yang, Guangning; Lu, Wei; Numata, Kenji

    2016-01-01

    An optical correlation receiver is described that provides ultra-precise distance and/or time/pulse-width measurements even for weak (single photons) and short (femtosecond) optical signals. A new type of optical correlation receiver uses a fourth-order (intensity) interferometer to provide micron distance measurements even for weak (single photons) and short (femtosecond) optical signals. The optical correlator uses a low-noise-integrating detector that can resolve photon number. The correlation (range as a function of path delay) is calculated from the variance of the photon number of the difference of the optical signals on the two detectors. Our preliminary proof-of principle data (using a short-pulse diode laser transmitter) demonstrates tens of microns precision.

  14. SAW correlator spread spectrum receiver

    DOEpatents

    Brocato, Robert W

    2014-04-01

    A surface acoustic wave (SAW) correlator spread-spectrum (SS) receiver is disclosed which utilizes a first demodulation stage with a chip length n and a second demodulation stage with a chip length m to decode a transmitted SS signal having a code length l=n.times.m which can be very long (e.g. up to 2000 chips or more). The first demodulation stage utilizes a pair of SAW correlators which demodulate the SS signal to generate an appropriate code sequence at an intermediate frequency which can then be fed into the second demodulation stage which can be formed from another SAW correlator, or by a digital correlator. A compound SAW correlator comprising two input transducers and a single output transducer is also disclosed which can be used to form the SAW correlator SS receiver, or for use in processing long code length signals.

  15. Thompson receives 1994 Bowen award

    NASA Astrophysics Data System (ADS)

    Green, David H.; Thompson, Alan Bruce

    At the Spring Meeting in Baltimore, May 23, 1994, Alan Bruce Thompson of the Eidgenossiche Technische Hochschule, Zurich, received the 1994 N. L. Bowen Award of the Volcanology, Geochemsitry, and Petrology section, which is given for a single outstanding contribution to volcanology, geochemistry, or petrology made during the preceding 5 years. The award was presented by David H. Green of the Research School of Earth Sciences. The citation and response are given here.

  16. Digital-data receiver synchronization

    DOEpatents

    Smith, Stephen F.; Turner, Gary W.

    2005-08-02

    Digital-data receiver synchronization is provided with composite phase-frequency detectors, mutually cross-connected comparison feedback or both to provide robust reception of digital data signals. A single master clock can be used to provide frequency signals. Advantages can include fast lock-up time in moderately to severely noisy conditions, greater tolerance to noise and jitter when locked, and improved tolerance to clock asymmetries.

  17. Physiology of central pathways.

    PubMed

    Cullen, K E

    2016-01-01

    The relative simplicity of the neural circuits that mediate vestibular reflexes is well suited for linking systems and cellular levels of analyses. Notably, a distinctive feature of the vestibular system is that neurons at the first central stage of sensory processing in the vestibular nuclei are premotor neurons; the same neurons that receive vestibular-nerve input also send direct projections to motor pathways. For example, the simplicity of the three-neuron pathway that mediates the vestibulo-ocular reflex leads to the generation of compensatory eye movements within ~5ms of a head movement. Similarly, relatively direct pathways between the labyrinth and spinal cord control vestibulospinal reflexes. A second distinctive feature of the vestibular system is that the first stage of central processing is strongly multimodal. This is because the vestibular nuclei receive inputs from a wide range of cortical, cerebellar, and other brainstem structures in addition to direct inputs from the vestibular nerve. Recent studies in alert animals have established how extravestibular signals shape these "simple" reflexes to meet the needs of current behavioral goal. Moreover, multimodal interactions at higher levels, such as the vestibular cerebellum, thalamus, and cortex, play a vital role in ensuring accurate self-motion and spatial orientation perception. PMID:27638060

  18. Surge-type glaciers in the Tien Shan (Central Asia)

    NASA Astrophysics Data System (ADS)

    Mukherjee, Kriti; Bolch, Tobias

    2016-04-01

    Surge-type glaciers in High Mountain Asia are mostly observed in Karakoram and Pamir. However, few surge-type glaciers also exist in the Tien Shan, but have not comprehensively studied in detail in the recent literature. We identified surge-type glaciers in the Tien Shan either from available literature or by manual interpretation using available satellite images (such as Corona, Hexagon, Landsat, SPOT, IRS) for the period 1960 to 2014. We identified 39 possible surge-type glaciers, showing typical characteristics like looped moraines. Twenty-two of them rapidly advanced during different periods or a surge was clearly described in the literature. For the remaining possible surge-type glaciers either the advance, in terms of time and length, were not mentioned in detail in the literature, or the glaciers have remained either stable or retreated during the entire period of our study. Most of the surge-type glaciers cluster in the Inner Tien Shan (especially in the Ak-Shiirak rage) and the Central Tien Shan, are in size and are facing North, West or North West. Pronounced surge events were observed for North Inylchek and Samoilowitsch glaciers, both of which are located in the Central Tien Shan. Samoilowitsch Glacier retreated by more than 3 km between 1960 (length ~8.9 km) and 1992 (~5.8 km), advanced by almost 3 km until 2006 and slightly retreated thereafter. The most pronounced advance occurred between 2000 and 2002. DEM differencing (based on SRTM3 data and stereo Hexagon and Cartosat-1 data) revealed a significant thickening in the middle reaches (reservoir area) of the glacier between 1973 and 2000 while the surface significantly lowered in the middle and upper parts of the glacier between 2000 and 2006. Hence, the ice mass was transferred to the lower reaches (receiving area) and caused the advance with a maximum thickening of more than 80 m. The ~30 km long North Inylchek Glacier retreated since 1943 and showed a very rapid advance of ~3.5 km especially in

  19. Stennis group receives NESC award

    NASA Technical Reports Server (NTRS)

    2009-01-01

    The NASA Engineering & Safety Center recently presented its Group Achievement Award to a Stennis team in recognition of technical excellence in evaluating the operational anomalies and reliability improvements associated with the space shuttle engine cut-off system. Stennis employees receiving the award were: (standing, l to r) Freddie Douglas (NASA), George Drouant (Jacobs Technology Inc.), Fred Abell (Jacobs), Robert Drackett (Jacobs) and Mike Smiles (NASA); (seated, l to r): Binh Nguyen (Jacobs), Stennis Director Gene Goldman and Joseph Lacker (NASA). Phillip Hebert of NASA is not pictured.

  20. Digital receiver study and implementation

    NASA Technical Reports Server (NTRS)

    Fogle, D. A.; Lee, G. M.; Massey, J. C.

    1972-01-01

    Computer software was developed which makes it possible to use any general purpose computer with A/D conversion capability as a PSK receiver for low data rate telemetry processing. Carrier tracking, bit synchronization, and matched filter detection are all performed digitally. To aid in the implementation of optimum computer processors, a study of general digital processing techniques was performed which emphasized various techniques for digitizing general analog systems. In particular, the phase-locked loop was extensively analyzed as a typical non-linear communication element. Bayesian estimation techniques for PSK demodulation were studied. A hardware implementation of the digital Costas loop was developed.

  1. Design of coherent receiver optical front end for unamplified applications.

    PubMed

    Zhang, Bo; Malouin, Christian; Schmidt, Theodore J

    2012-01-30

    Advanced modulation schemes together with coherent detection and digital signal processing has enabled the next generation high-bandwidth optical communication systems. One of the key advantages of coherent detection is its superior receiver sensitivity compared to direct detection receivers due to the gain provided by the local oscillator (LO). In unamplified applications, such as metro and edge networks, the ultimate receiver sensitivity is dictated by the amount of shot noise, thermal noise, and the residual beating of the local oscillator with relative intensity noise (LO-RIN). We show that the best sensitivity is achieved when the thermal noise is balanced with the residual LO-RIN beat noise, which results in an optimum LO power. The impact of thermal noise from the transimpedance amplifier (TIA), the RIN from the LO, and the common mode rejection ratio (CMRR) from a balanced photodiode are individually analyzed via analytical models and compared to numerical simulations. The analytical model results match well with those of the numerical simulations, providing a simplified method to quantify the impact of receiver design tradeoffs. For a practical 100 Gb/s integrated coherent receiver with 7% FEC overhead, we show that an optimum receiver sensitivity of -33 dBm can be achieved at GFEC cliff of 8.55E-5 if the LO power is optimized at 11 dBm. We also discuss a potential method to monitor the imperfections of a balanced and integrated coherent receiver.

  2. Front end for GPS receivers

    NASA Technical Reports Server (NTRS)

    Thomas, Jr., Jess Brooks (Inventor)

    1999-01-01

    The front end in GPS receivers has the functions of amplifying, down-converting, filtering and sampling the received signals. In the preferred embodiment, only two operations, A/D conversion and a sum, bring the signal from RF to filtered quadrature baseband samples. After amplification and filtering at RF, the L1 and L2 signals are each sampled at RF at a high selected subharmonic rate. The subharmonic sample rates are approximately 900 MHz for L1 and 982 MHz for L2. With the selected subharmonic sampling, the A/D conversion effectively down-converts the signal from RF to quadrature components at baseband. The resulting sample streams for L1 and L2 are each reduced to a lower rate with a digital filter, which becomes a straight sum in the simplest embodiment. The frequency subsystem can be very simple, only requiring the generation of a single reference frequency (e.g. 20.46 MHz minus a small offset) and the simple multiplication of this reference up to the subharmonic sample rates for L1 and L2. The small offset in the reference frequency serves the dual purpose of providing an advantageous offset in the down-converted carrier frequency and in the final baseband sample rate.

  3. MRDIS Standalone Central Alarm Station

    SciTech Connect

    2012-09-12

    The MRDIS Standalone Central Alarm Station(MRDIS-CAS} is a software system for receiving, storing, and reviewing radiation data collected by the Mobile Radiation Detection and Identification System (MRDIS}, a mobile radiation scanning system developed for use in foreign ports for the DOE Megaports Initiative. It is designed to run on one of the on board computers in the MRDIS cab. It will collect, store, and display data from the MRDIS without the need for wireless communications or centralized server technology. It is intended to be a lightweight replacement for a distributed Megaports communication system in ports where the necessary communications infrastructure does not exist for a full Megaports communications system.

  4. Demographic tensions in Central America.

    PubMed

    1986-08-01

    This discussion of Central America focuses on the rapid growth of its population, its stagnating economy, and those countries that are socioeconomically advanced. Between 1950-85 the population of Central America tripled, from 9.1 million to 26. 4 million, due to marked mortality declines and the absence of off-setting fertility declines. The distribution of Central Americas's growing populations sets its population growth apart from that of other developing regions. Currently, almost half of all Central Americans live in cities. Although the average growth rate for Central American countries has fallen and is expected to drop further, the decline does not counterbalance the effect of the absolute rise in population numbers. The average annual growth rate of more than 3% annually in the 1960s fell to about 2.6% in recent years, but this decline is due primarily to socioeconomically advanced Costa Rica and Panama. Central America's age structure further complicates the population crisis. About 43% of Central Americans are under the age of 15. When the increasingly larger young population group enters it reproductive years, the potential for future growth (albeit the falling rate of population increase) is unparalleled. UN population projections show the region's population at 40 million by the year 2000. The 1973 oil crisis began a downward spiral for the buoyant post World War II Central American economy. Between 1950-79, real per capita income growth in Central America doubled, with Central American economies growing an average of 5.3% annually. By the early 1980s, overseas markets of the trade-dependent countries of Central America had dried up due to protectionism abroad and slumping basic commodity prices. These and other factors plunged Central America into its current economic malaise of falling real per capita income, rising unemployment, curtailed export led economic growth, and a rising cost of living. In general, economic growth in Central America

  5. Sheeley Receives 2009 Hale Prize

    NASA Astrophysics Data System (ADS)

    Tretkoff, Ernie

    2009-05-01

    Neil Sheeley Jr., of the Space Science Division of the Naval Research Laboratory (NRL), has been awarded the 2009 George Ellery Hale Prize by the Solar Physics Division of the American Astronomical Society (AAS). The international award recognizes work in solar astronomy done over an extended period of time. Sheeley will receive the award in June at the AAS meeting in Pasadena, Calif. Sheeley is cited "for his continuing outstanding contributions to our understanding of the solar magnetic field, coronal holes, and coronal mass ejections. His wide-ranging observational and theoretical work has laid the foundation for much current research in solar and heliospheric physics, and continues to have important applications in space weather prediction."

  6. POVM Receivers for Quantum Cryptography

    NASA Astrophysics Data System (ADS)

    Brandt, H. E.

    1997-04-01

    Positive operator valued measures (POVMs) are finding increasing use in quantum cryptography.(A. Peres, Quantum Theory: Concepts and Methods, Kluwer Academic Publishers, Boston (1993).) I present quantum circuit analyses of two recently proposed (H. E. Brandt, J. M. Myers, and S. J. Lomonaco Jr., "New Results in Entangled Translucent Eavesdropping in Quantum Cryptography," in Photonic Quantum Computing, S. P. Hotaling and A. R. Pirich, Editors, Proc. SPIE 3076 (1997)) all-optical designs for POVM receivers to be used in conjunction with Bennett's B92 protocol for key distribution based on two photon polarization states. Expectation values for the POVM operators are calculated and shown to be faithfully realized by the POVM detectors.

  7. A cryogenic receiver for EPR.

    PubMed

    Narkowicz, R; Ogata, H; Reijerse, E; Suter, D

    2013-12-01

    Cryogenic probes have significantly increased the sensitivity of NMR. Here, we present a compact EPR receiver design capable of cryogenic operation. Compared to room temperature operation, it reduces the noise by a factor of ≈2.5. We discuss in detail the design and analyze the resulting noise performance. At low microwave power, the input noise density closely follows the emission of a cooled 50Ω resistor over the whole measurement range from 20K up to room temperature. To minimize the influence of the microwave source noise, we use high microwave efficiency (≈1.1-1.7mTW(-1/2)) planar microresonators. Their efficient conversion of microwave power to magnetic field permits EPR measurements with very low power levels, typically ranging from a few μW down to fractions of nW.

  8. Preamplifier Noise in VLF Receivers

    NASA Technical Reports Server (NTRS)

    Burhans, R. W.

    1978-01-01

    Noise specifications for junction field-effect transistors are presented in different ways depending on the particular semiconductor manufacturer. Arithmetic involved in converting these specifications to equivalent RMS noise in microvolts developed at the preamplifier input terminal is reviewed. These methods were useful for estimating the noise performance of high input impedance preamplifiers used with E-field antennas operating in the range of 1 KHz to 10 MHz. Both the JFET MPF-102 transistor and the COS/MOS CA3600 transistor array provided amplification for VLF receivers where the internally generated noise was well below the atmospheric noise level. The CA3600 transistor array provided better performance because of the more symmetrical complementary MOS transistor transfer characteristics than a single N-type biased JFET transistor. The CMOS amplifier resulted in self-compensating gain characteristics over a very wide temperature range from -55 to +125 C.

  9. 9. NORTHEAST FROM SOUTH ENTRANCE ACROSS RECEIVING AREA OF FACTORY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. NORTHEAST FROM SOUTH ENTRANCE ACROSS RECEIVING AREA OF FACTORY PAST THE GLASS-ENCLOSED OFFICE TOWARD SHOP AREA. BESIDE THE VERTICAL POST ROOF SUPPORT IN THE LEFT FOREGROUND IS A SCALE AND DRAFTING TABLE. BESIDE THE OFFICE WALL ON THE RIGHT IS A SMALL SHOP REPAIR BENCH, WHILE ABOVE THE OFFICE WINDOWS ARE BOXES OF COMPANY MANUSCRIPT BUSINESS RECORDS. THE WELDED METAL PIPE RACK IS A MODERN INTRUSION. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  10. Dunne receives 2011 G. K. Gilbert Award: Citation

    NASA Astrophysics Data System (ADS)

    Dietrich, William E.

    2012-06-01

    Thomas Dunne received the 2011 G. K. Gilbert Award at the 2011 AGU Fall Meeting, held 5-9 December in San Francisco, Calif. The award recognizes “a scientist who has either made a single significant advance or sustained significant contributions to the field of Earth and planetary surface processes, and who has in addition promoted an environment of unselfish cooperation in research and the inclusion of young scientists into the field.”

  11. Dunne receives 2011 G. K. Gilbert Award: Response

    NASA Astrophysics Data System (ADS)

    Dunne, Thomas

    2012-06-01

    Thomas Dunne received the 2011 G. K. Gilbert Award at the 2011 AGU Fall Meeting, held 5-9 December in San Francisco, Calif. The award recognizes “a scientist who has either made a single significant advance or sustained significant contributions to the field of Earth and planetary surface processes, and who has in addition promoted an environment of unselfish cooperation in research and the inclusion of young scientists into the field.”

  12. Dietrich receives 2010 G. K. Gilbert Award: Citation

    NASA Astrophysics Data System (ADS)

    Howard, Alan D.

    2011-06-01

    William E. Dietrich received the 2010 G. K. Gilbert Award at the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. The award recognizes “a scientist who has either made a single significant advance or sustained significant contributions to the field of Earth and planetary surface processes, and who has in addition promoted an environment of unselfish cooperation in research and the inclusion of young scientists into the field.”

  13. Dietrich receives 2010 G. K. Gilbert Award: Response

    NASA Astrophysics Data System (ADS)

    Dietrich, William E.

    2011-06-01

    William E. Dietrich received the 2010 G. K. Gilbert Award at the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. The award recognizes “a scientist who has either made a single significant advance or sustained significant contributions to the field of Earth and planetary surface processes, and who has in addition promoted an environment of unselfish cooperation in research and the inclusion of young scientists into the field.”

  14. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  15. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  16. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  17. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 13 Business Credit and Assistance 1 2014-01-01 2014-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  18. 13 CFR 120.1723 - Pool Loan receivables received by Seller.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Pool Loan receivables received by... LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools § 120.1723 Pool Loan receivables received by Seller. Any Pool Loan Receivables received by Seller...

  19. 18 CFR 367.1710 - Account 171, Interest and dividends receivable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ACT OF 2005, FEDERAL POWER ACT AND NATURAL GAS ACT UNIFORM SYSTEM OF ACCOUNTS FOR CENTRALIZED SERVICE... NATURAL GAS ACT Balance Sheet Chart of Accounts Current and Accrued Assets § 367.1710 Account 171... receivable from associate companies must be included in account 146, Accounts receivable from...

  20. Fluid absorption solar energy receiver

    NASA Technical Reports Server (NTRS)

    Bair, Edward J.

    1993-01-01

    A conventional solar dynamic system transmits solar energy to the flowing fluid of a thermodynamic cycle through structures which contain the gas and thermal energy storage material. Such a heat transfer mechanism dictates that the structure operate at a higher temperature than the fluid. This investigation reports on a fluid absorption receiver where only a part of the solar energy is transmitted to the structure. The other part is absorbed directly by the fluid. By proportioning these two heat transfer paths the energy to the structure can preheat the fluid, while the energy absorbed directly by the fluid raises the fluid to its final working temperature. The surface temperatures need not exceed the output temperature of the fluid. This makes the output temperature of the gas the maximum temperature in the system. The gas can have local maximum temperatures higher than the output working temperature. However local high temperatures are quickly equilibrated, and since the gas does not emit radiation, local high temperatures do not result in a radiative heat loss. Thermal radiation, thermal conductivity, and heat exchange with the gas all help equilibrate the surface temperature.

  1. Recent developments in superconducting receivers

    SciTech Connect

    Richards, P.L.

    1990-09-01

    A description is given of recent work at Berkeley on superconducting mixers and detectors for infrared and millimeter wavelengths. The first report is a review article which summarizes the status of development of superconducting components for infrared and millimeter wave receivers. The next report describes accurate measurements and also theoretical modeling of an SIS quasiparticle waveguide mixer for W-band which uses very high quality Ta junctions. The best mixer noise is only 1.3 times the quantum limit. Both the mixer gain and the noise are in quantitative agreement with the quantum theory. Next, a report is given on measurements and theoretical modeling of the absorptivity (surface resistance) of high quality epitaxial films of the high {Tc} superconductor YBCO from 750 GHz to 21 THz. Finally, there are reports on the design and experimental performance of two different types of high {Tc} bolometric detectors. One is a conventional bolometer with a gold-black absorber. The other is an antenna coupled microbolometer.

  2. Lunar Receiving Laboratory Project History

    NASA Technical Reports Server (NTRS)

    Mangus, Susan; Larsen, William

    2004-01-01

    As early as 1959, the Working Group on Lunar Exploration within NASA advocated that 'one of the prime objectives of the first lunar landing mission should be the collection of samples for return to Earth, where they could be subjected to detailed study and analysis.' Within NASA, neither this group nor any other scientists working with the Agency were concerned about back contamination issues. Outside of NASA, back contamination concerns had been raised as early as 1960. Although NASA did not seem to pay any attention to the concerns at that time, the scientific community continued to be interested in the topic. In 1962 and again in 1963, as the Apollo Program loomed large, further discussions were held. These early discussions of back contamination did not make their way into NASA's administration, however, and when Manned Spacecraft Center personnel began to articulate early concepts for the Lunar Receiving Laboratory (LRL), the back contamination issue was not considered. Once this concern became a major focus, however, the LRL's development became increasingly complex. This is the history of that development.

  3. Development of the Multi-Level Seismic Receiver (MLSR)

    SciTech Connect

    Sleefe, G.E.; Engler, B.P.; Drozda, P.M.; Franco, R.J.; Morgan, J.

    1995-02-01

    The Advanced Geophysical Technology Department (6114) and the Telemetry Technology Development Department (2664) have, in conjunction with the Oil Recovery Technology Partnership, developed a Multi-Level Seismic Receiver (MLSR) for use in crosswell seismic surveys. The MLSR was designed and evaluated with the significant support of many industry partners in the oil exploration industry. The unit was designed to record and process superior quality seismic data operating in severe borehole environments, including high temperature (up to 200{degrees}C) and static pressure (10,000 psi). This development has utilized state-of-the-art technology in transducers, data acquisition, and real-time data communication and data processing. The mechanical design of the receiver has been carefully modeled and evaluated to insure excellent signal coupling into the receiver.

  4. Time Perception Mechanisms at Central Nervous System

    PubMed Central

    Fontes, Rhailana; Ribeiro, Jéssica; Gupta, Daya S.; Machado, Dionis; Lopes-Júnior, Fernando; Magalhães, Francisco; Bastos, Victor Hugo; Rocha, Kaline; Marinho, Victor; Lima, Gildário; Velasques, Bruna; Ribeiro, Pedro; Orsini, Marco; Pessoa, Bruno; Leite, Marco Antonio Araujo; Teixeira, Silmar

    2016-01-01

    The five senses have specific ways to receive environmental information and lead to central nervous system. The perception of time is the sum of stimuli associated with cognitive processes and environmental changes. Thus, the perception of time requires a complex neural mechanism and may be changed by emotional state, level of attention, memory and diseases. Despite this knowledge, the neural mechanisms of time perception are not yet fully understood. The objective is to relate the mechanisms involved the neurofunctional aspects, theories, executive functions and pathologies that contribute the understanding of temporal perception. Articles form 1980 to 2015 were searched by using the key themes: neuroanatomy, neurophysiology, theories, time cells, memory, schizophrenia, depression, attention-deficit hyperactivity disorder and Parkinson’s disease combined with the term perception of time. We evaluated 158 articles within the inclusion criteria for the purpose of the study. We conclude that research about the holdings of the frontal cortex, parietal, basal ganglia, cerebellum and hippocampus have provided advances in the understanding of the regions related to the perception of time. In neurological and psychiatric disorders, the understanding of time depends on the severity of the diseases and the type of tasks. PMID:27127597

  5. Development of Retinoblastoma Programs in Central America

    PubMed Central

    Wilimas, Judith A.; Wilson, Matthew W.; Haik, Barrett G.; Barnoya, Margarita; Fu, Ligia; Castellanos, Mauricio; Bonilla, Miguel; Phillips, Blanca; Helveston, Eugene M.; Luna-Fineman, Sandra; Ribeiro, Raul; Rodriguez-Galindo, Carlos

    2009-01-01

    Background Retinoblastoma, a curable eye tumor, is associated with poor survival in Central America (CA). To develop a retinoblastoma program in El Salvador, Guatemala, and Honduras, twinning initiatives were undertaken between local pediatric oncology centers, nonprofit foundations, St. Jude Children's Research Hospital, and the University of Tennessee Hamilton Eye Institute. Procedure The retinoblastoma program focused on developing early diagnosis programs in Honduras with national vaccination campaigns, developing treatment protocols suited to local conditions, building local networks of oncologists and ophthalmologists, training local healthcare providers, using modern donated equipment for diagnosis and treatment, and the ORBIS Cybersight consultation program and Internet meetings to further education and share expertise. Pediatric ophthalmologists and oncologists worked with foundations to treat patients locally with donated equipment and Internet consultations, or at the center in Guatemala. Results Number of patients successfully treated increased after the program was introduced. For 2000–2003 and 2004–2007, patients abandoning/refusing treatment decreased in Guatemala from 20 of 95 (21%) to 14 of 123 (11%) and in Honduras from 13 of 37 (35%) to 7 of 37 (19%). Survival in El Salvador was good and abandonment/refusal low for both periods. Of 18 patients receiving focal therapy for advanced disease, 14 have single remaining eyes. Conclusion Development of the program in CA has decreased abandonment/refusal and enabled ophthalmologists at local centers to use modern equipment to provide better treatment. This approach might serve as a guide for developing other multispecialty programs. PMID:19326423

  6. Integrated Cryogenic Satellite Communications Cross-Link Receiver Experiment

    NASA Technical Reports Server (NTRS)

    Romanofsky, R. R.; Bhasin, K. B.; Downey, A. N.; Jackson, C. J.; Silver, A. H.; Javadi, H. H. S.

    1995-01-01

    An experiment has been devised which will validate, in space, a miniature, high-performance receiver. The receiver blends three complementary technologies; high temperature superconductivity (HTS), pseudomorphic high electron mobility transistor (PHEMT) monolithic microwave integrated circuits (MMIC), and a miniature pulse tube cryogenic cooler. Specifically, an HTS band pass filter, InP MMIC low noise amplifier, HTS-sapphire resonator stabilized local oscillator (LO), and a miniature pulse tube cooler will be integrated into a complete 20 GHz receiver downconverter. This cooled downconverter will be interfaced with customized signal processing electronics and integrated onto the space shuttle's 'HitchHiker' carrier. A pseudorandom data sequence will be transmitted to the receiver, which is in low Earth orbit (LEO), via the Advanced Communication Technology Satellite (ACTS) on a 20 GHz carrier. The modulation format is QPSK and the data rate is 2.048 Mbps. The bit error rate (BER) will be measured in situ. The receiver is also equipped with a radiometer mode so that experiment success is not totally contingent upon the BER measurement. In this mode, the receiver uses the Earth and deep space as a hot and cold calibration source, respectively. The experiment closely simulates an actual cross-link scenario. Since the receiver performance depends on channel conditions, its true characteristics would be masked in a terrestrial measurement by atmospheric absorption and background radiation. Furthermore, the receiver's performance depends on its physical temperature, which is a sensitive function of platform environment, thermal design, and cryocooler performance. This empirical data is important for building confidence in the technology.

  7. The Advanced Communication Technology Satellite and ISDN

    NASA Technical Reports Server (NTRS)

    Lowry, Peter A.

    1996-01-01

    This paper depicts the Advanced Communication Technology Satellite (ACTS) system as a global central office switch. The ground portion of the system is the collection of earth stations or T1-VSAT's (T1 very small aperture terminals). The control software for the T1-VSAT's resides in a single CPU. The software consists of two modules, the modem manager and the call manager. The modem manager (MM) controls the RF modem portion of the T1-VSAT. It processes the orderwires from the satellite or from signaling generated by the call manager (CM). The CM controls the Recom Laboratories MSPs by receiving signaling messages from the stacked MSP shelves ro units and sending appropriate setup commands to them. There are two methods used to setup and process calls in the CM; first by dialing up a circuit using a standard telephone handset or, secondly by using an external processor connected to the CPU's second COM port, by sending and receiving signaling orderwires. It is the use of the external processor which permits the ISDN (Integrated Services Digital Network) Signaling Processor to implement ISDN calls. In August 1993, the initial testing of the ISDN Signaling Processor was carried out at ACTS System Test at Lockheed Marietta, Princeton, NJ using the spacecraft in its test configuration on the ground.

  8. Bevacizumab improves survival for patients with advanced cervical cancer

    Cancer.gov

    Patients with advanced, recurrent, or persistent cervical cancer that was not curable with standard treatment who received the drug bevacizumab (Avastin) lived 3.7 months longer than patients who did not receive the drug, according to an interim analysis

  9. Advance care directives

    MedlinePlus

    ... advance directive; Do-not-resuscitate - advance directive; Durable power of attorney - advance care directive; POA - advance care directive; Health care agent - advance care directive; Health care proxy - ...

  10. Electronic and mechanical improvement of the receiving terminal of a free-space microwave power transmission system

    NASA Technical Reports Server (NTRS)

    Brown, W. C.

    1977-01-01

    Significant advancements were made in a number of areas: improved efficiency of basic receiving element at low power density levels, improved resolution and confidence in efficiency measurements mathematical modelling and computer simulation of the receiving element and the design, construction, and testing of an environmentally protected two-plane construction suitable for low cost, highly automated construction of large receiving arrays.

  11. Advanced satellite communication system

    NASA Technical Reports Server (NTRS)

    Staples, Edward J.; Lie, Sen

    1992-01-01

    The objective of this research program was to develop an innovative advanced satellite receiver/demodulator utilizing surface acoustic wave (SAW) chirp transform processor and coherent BPSK demodulation. The algorithm of this SAW chirp Fourier transformer is of the Convolve - Multiply - Convolve (CMC) type, utilizing off-the-shelf reflective array compressor (RAC) chirp filters. This satellite receiver, if fully developed, was intended to be used as an on-board multichannel communications repeater. The Advanced Communications Receiver consists of four units: (1) CMC processor, (2) single sideband modulator, (3) demodulator, and (4) chirp waveform generator and individual channel processors. The input signal is composed of multiple user transmission frequencies operating independently from remotely located ground terminals. This signal is Fourier transformed by the CMC Processor into a unique time slot for each user frequency. The CMC processor is driven by a waveform generator through a single sideband (SSB) modulator. The output of the coherent demodulator is composed of positive and negative pulses, which are the envelopes of the chirp transform processor output. These pulses correspond to the data symbols. Following the demodulator, a logic circuit reconstructs the pulses into data, which are subsequently differentially decoded to form the transmitted data. The coherent demodulation and detection of BPSK signals derived from a CMC chirp transform processor were experimentally demonstrated and bit error rate (BER) testing was performed. To assess the feasibility of such advanced receiver, the results were compared with the theoretical analysis and plotted for an average BER as a function of signal-to-noise ratio. Another goal of this SBIR program was the development of a commercial product. The commercial product developed was an arbitrary waveform generator. The successful sales have begun with the delivery of the first arbitrary waveform generator.

  12. Percentage of Surgical Patients Receiving Recommended Care

    MedlinePlus

    ... Recommended Care Percentage of Surgical Patients Receiving Recommended Care This is a composite measure based on individual ... Age Group Percentage of Surgical Patients Receiving Recommended Care by Age Group uzrc-9bvr Download these data » ...

  13. Optimization of MLS receivers for multipath environments

    NASA Technical Reports Server (NTRS)

    Mcalpine, G. A.; Irwin, S. H.; NELSON; Roleyni, G.

    1977-01-01

    Optimal design studies of MLS angle-receivers and a theoretical design-study of MLS DME-receivers are reported. The angle-receiver results include an integration of the scan data processor and tracking filter components of the optimal receiver into a unified structure. An extensive simulation study comparing the performance of the optimal and threshold receivers in a wide variety of representative dynamical interference environments was made. The optimal receiver was generally superior. A simulation of the performance of the threshold and delay-and-compare receivers in various signal environments was performed. An analysis of combined errors due to lateral reflections from vertical structures with small differential path delays, specular ground reflections with neglible differential path delays, and thermal noise in the receivers is provided.

  14. The First Six ALMA Band 10 Receivers

    NASA Astrophysics Data System (ADS)

    Fujii, Y.; Gonzalez, A.; Kroug, M.; Kaneko, K.; Miyachi, A.; Yokoshima, T.; Kuroiwa, K.; Ogawa, H.; Makise, K.; Wang, Z.; Uzawa, Y.

    2013-01-01

    The first six Atacama Large Millimeter/submillimeter Array (ALMA) Band 10 (787-950 GHz) receivers have been developed and characterized during the receiver preproduction phase. State-of-the-art measurement systems at THz frequencies have been implemented and successfully used to measure the performance of the first six receivers. Extensive tests ranging from receiver sensitivity and stability to optical aperture efficiency on the secondary antenna have been performed. Performance of all six receivers is well within the stringent ALMA requirements. Moreover, our extensive tests have shown that there are no big performance differences between receivers. These results indicate that the ALMA Band 10 receiver is ready for the production phase, during which an additional 67 receivers will be produced and characterized.

  15. High speed receiver for capsule endoscope.

    PubMed

    Woo, S H; Yoon, K W; Moon, Y K; Lee, J H; Park, H J; Kim, T W; Choi, H C; Won, C H; Cho, J H

    2010-10-01

    In this study, a high-speed receiver for a capsule endoscope was proposed and implemented. The proposed receiver could receive 20 Mbps data that was sufficient to receive images with a higher resolution than conventional receivers. The receiver used a 1.2 GHz band to receive radio frequency (RF) signal, and demodulated the signal to an intermediate frequency (IF) stage (150 MHz). The demodulated signal was amplified, filtered, and under-sampled by a high-speed analog-to-digital converter (ADC). In order to decode the under-sampled data in real time, a simple frequency detection algorithm was selected and was implemented by using a FPGA. The implemented system could receive 20 Mbps data.

  16. Trough Receiver Heat Loss Testing (Presentation)

    SciTech Connect

    Lewandowski, A.; Feik, C.; Hansen, R.; Phillips, S.; Bingham, C.; Netter, J.; Forristal, R.; Burkholder, F.; Meglan, B.; Wolfrum, E.

    2006-02-01

    This presentation describes the design, fabrication, and qualification of an experimental capability for thermal loss testing of full-size trough receiver elements; and the testing on a variety of receivers.

  17. How To Improve You Shipping and Receiving.

    ERIC Educational Resources Information Center

    Sturgeon, Julie

    2001-01-01

    Discusses how two universities improved their shipping and receiving operations and cut costs. Examples from the University of Texas at Dallas and John Hopkins University, Baltimore, Maryland, illustrate how they established greater shipping and receiving department efficiencies. (GR)

  18. Engineering and economic evaluation of central-station photovoltaic power plants

    SciTech Connect

    Stolte, W.J. )

    1992-12-01

    This report describes the conceptual design, design optimization, and estimated cost and performance of three 50 MW photovoltaic power plants. The first design uses Fresnel lens/glass silo modules mounted on two-axis tracking arrays. The second design has all of the cells mounted on a central receiver on top of a single tower, with heliostats concentrating sunlight onto the receiver. Both designs are based on a similar advanced back-contact silicon concentrator cell developed under EPRI sponsorship. The third design uses thin-film copper indium diselenide flat-plate modules mounted on fixed-tilt array structures. The design and manufacture of the photovoltaic cells and modules are described, along with selection of the photovoltaic technologies, generating and cell manufacturing plant sites. Power system simulation and revenue requirement analyses are included for all of the plant designs.

  19. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 7 2014-07-01 2014-07-01 false Air receivers. 1917.155 Section 1917.155 Labor Regulations...) MARINE TERMINALS Related Terminal Operations and Equipment § 1917.155 Air receivers. (a) Application. This section applies to compressed air receivers and equipment used for operations such as...

  20. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 7 2012-07-01 2012-07-01 false Air receivers. 1917.155 Section 1917.155 Labor Regulations...) MARINE TERMINALS Related Terminal Operations and Equipment § 1917.155 Air receivers. (a) Application. This section applies to compressed air receivers and equipment used for operations such as...

  1. Battle Keeps Solar Energy in Receiver

    NASA Technical Reports Server (NTRS)

    Mcdougal, A. R.; Hale, R. R.

    1982-01-01

    Mirror structure in solar concentrator reduces heat loss by reflection and reradiation. Baffle reflects entering rays back and forth in solar-concentrator receiver until they reach heat exchanger. Similarly, infrared energy reradiated by heat exchanger is prevented from leaving receiver. Surfaces of baffle and inside wall of receiver are polished and highly reflective at solar and infrared wavelengths.

  2. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Receiver. 80.1013 Section 80.1013 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be...

  3. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  4. 21 CFR 1020.10 - Television receivers.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... volts if the receiver is designed to operate from nominal 110 to 120 root mean square volt power sources. If the receiver is designed to operate from a power source having some voltage other than from... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Television receivers. 1020.10 Section 1020.10...

  5. 21 CFR 1020.10 - Television receivers.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... volts if the receiver is designed to operate from nominal 110 to 120 root mean square volt power sources. If the receiver is designed to operate from a power source having some voltage other than from... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Television receivers. 1020.10 Section 1020.10...

  6. 21 CFR 1020.10 - Television receivers.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... volts if the receiver is designed to operate from nominal 110 to 120 root mean square volt power sources. If the receiver is designed to operate from a power source having some voltage other than from... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Television receivers. 1020.10 Section 1020.10...

  7. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  8. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  9. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  10. 49 CFR 393.88 - Television receivers.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Television receivers. 393.88 Section 393.88... NECESSARY FOR SAFE OPERATION Miscellaneous Parts and Accessories § 393.88 Television receivers. Any motor vehicle equipped with a television viewer, screen or other means of visually receiving a...

  11. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 7 2010-07-01 2010-07-01 false Air receivers. 1917.155 Section 1917.155 Labor Regulations...) MARINE TERMINALS Related Terminal Operations and Equipment § 1917.155 Air receivers. (a) Application. This section applies to compressed air receivers and equipment used for operations such as...

  12. 49 CFR 236.730 - Coil, receiver.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Coil, receiver. 236.730 Section 236.730 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Coil, receiver. Concentric layers of insulated wire wound around the core of a receiver of an...

  13. 49 CFR 236.730 - Coil, receiver.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 4 2011-10-01 2011-10-01 false Coil, receiver. 236.730 Section 236.730 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... Coil, receiver. Concentric layers of insulated wire wound around the core of a receiver of an...

  14. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Receiver. 80.1013 Section 80.1013 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be...

  15. Felt-metal-wick heat-pipe solar receiver

    SciTech Connect

    Andraka, C.E.; Adkins, D.R.; Moss, T.A.; Cole, H.M.; Andreas, N.H.

    1994-12-31

    Reflux heat-pipe receivers have been identified as a desirable interface to couple a Stirling-cycle engine with a parabolic dish solar concentrator. The reflux receiver provides power nearly isothermally to the engine heater heads while decoupling the heater head design from the solar absorber surface design. The independent design of the receiver and engine heater head leads to higher system efficiency. Heat pipe reflux receivers have been demonstrated at approximately 65 kW{sub t} power throughput. Several 25 to 30-kW{sub e} Stirling-cycle engines are under development, and will soon be incorporated in commercial dish-Stirling systems. These engines will require reflux receivers with power throughput limits reaching 90-kW{sub t}. The extension of heat pipe technology from 60 kW{sub t} to 100 kW{sub t} is not trivial. Current heat pipe wick technology is pushed to its limits. It is necessary to develop and test advanced wick structure technologies to perform this task. Sandia has developed and begun testing a Bekaert Corporation felt metal wick structure fabricated by Porous Metal Products Inc. This wick is about 95% porous, and has liquid permeability a factor of 2 to 8 times higher than conventional technologies for a given maximum pore radius. The wick has been successfully demonstrated in a bench-scale heat pipe, and a full-scale on-sun receiver has been fabricated. This report details the wick design, characterization and installation into a heat pipe receiver, and the results of the bench-scale tests are presented. The wick performance is modeled, and the model results are compared to test results.

  16. Felt-metal-wick heat-pipe solar receiver

    NASA Astrophysics Data System (ADS)

    Andraka, Charles E.; Adkins, Douglas R.; Moss, Timothy A.; Cole, Howard M.; Andreas, Nicos H.

    1994-09-01

    Reflux heat-pipe receivers have been identified as a desirable interface to couple a Stirling-cycle engine with a parabolic dish solar concentrator. The reflux receiver provides power nearly isothermally to the engine heater heads while decoupling the heater head design from the solar absorber surface design. The independent design of the receiver and engine heater head leads to higher system efficiency. Heat pipe reflux receivers have been demonstrated at approximately 65 kW(sub t) power throughput. Several 25 to 30 kW(sub e) Stirling-cycle engines are under development, and will soon be incorporated in commercial dish-Stirling systems. These engines will require reflux receivers with power throughput limits reaching 90 kW(sub t). The extension of heat pipe technology from 60 kW(sub t) to 100 kW(sub t) is not trivial. Current heat pipe wick technology is pushed to its limits. It is necessary to develop and test advanced wick structure technologies to perform this task. Sandia has developed and begun testing a Bekaert Corporation felt metal wick structure fabricated by Porous Metal Products Inc. This wick is about 95% porous, and has liquid permeability a factor of 2 to 8 times higher than conventional technologies for a given maximum pore radius. The wick has been successfully demonstrated in a bench-scale heat pipe, and a full-scale on-sun receiver has been fabricated. This report details the wick design, characterization and installation into a heat pipe receiver, and the results of the bench-scale tests are presented. The wick performance is modeled, and the model results are compared to test results.

  17. Wide-band coherent receiver development for enhanced surveillance

    SciTech Connect

    Simpson, M.L.; Richards, R.K.; Hutchinson, D.P.

    1998-03-01

    Oak Ridge National Laboratory (ORNL) has been developing advanced coherent IR heterodyne receivers for plasma diagnostics in fusion reactors for over 20 years. Recent progress in wide band IR detectors and high speed electronics has significantly enhanced the measurement capabilities of coherent receivers. In addition, developments in new HgCdTe and quantum well IR photodetector (QWIP) focal plane arrays are providing the possibility of both active and passive coherent imaging. In this paper the authors discuss the implications of these new enabling technologies to the IR remote sensing community for enhanced surveillance. Coherent receivers, as opposed to direct or thermal detection, provide multiple dimensions of information about a scene or target in a single detector system. Combinations of range, velocity, temperature, and chemical species information are all available from a coherent heterodyne receiver. They present laboratory data showing measured noise equivalent power (NEP) of new QWIP detectors with heterodyne bandwidths greater than 7 GHz. For absorption measurements, a wide band coherent receiver provides the capability of looking between CO{sub 2} lines at off-resonance peaks and thus the measurement of lines normally inaccessible with conventional heterodyne or direct detection systems. Also described are differential absorption lidar (DIAL) and Doppler laboratory measurements using an 8 x 8 HgCdTe focal plane array demonstrating the snapshot capability of coherent receiver detector arrays for enhanced chemical plume and moving hardbody capture. Finally they discuss a variety of coherent receiver configurations that can suppress (or enhance) sensitivity of present active remote sensing systems to speckle, glint, and other measurement anomalies.

  18. A zero-power radio receiver.

    SciTech Connect

    Brocato, Robert Wesley

    2004-09-01

    This report describes both a general methodology and some specific examples of passive radio receivers. A passive radio receiver uses no direct electrical power but makes sole use of the power available in the radio spectrum. These radio receivers are suitable as low data-rate receivers or passive alerting devices for standard, high power radio receivers. Some zero-power radio architectures exhibit significant improvements in range with the addition of very low power amplifiers or signal processing electronics. These ultra-low power radios are also discussed and compared to the purely zero-power approaches.

  19. More Efficient Solar Thermal-Energy Receiver

    NASA Technical Reports Server (NTRS)

    Dustin, M. O.

    1987-01-01

    Thermal stresses and reradiation reduced. Improved design for solar thermal-energy receiver overcomes three major deficiencies of solar dynamic receivers described in literature. Concentrator and receiver part of solar-thermal-energy system. Receiver divided into radiation section and storage section. Concentrated solar radiation falls on boiling ends of heat pipes, which transmit heat to thermal-energy-storage medium. Receiver used in number of applications to produce thermal energy directly for use or to store thermal energy for subsequent use in heat engine.

  20. Optimization of MLS receivers for multipath environments

    NASA Technical Reports Server (NTRS)

    Mcalpine, G. A.; Highfill, J. H., III

    1979-01-01

    The angle tracking problems in microwave landing system receivers along with a receiver design capable of optimal performance in the multipath environments found in air terminal areas were studied. Included were various theoretical and evaluative studies like: (1) signal model development; (2) derivation of optimal receiver structures; and (3) development and use of computer simulations for receiver algorithm evaluation. The development of an experimental receiver for flight testing is presented. An overview of the work and summary of principal results and conclusions are reported.

  1. A minimalist approach to receiver architecture

    NASA Technical Reports Server (NTRS)

    Collins, O.

    1991-01-01

    New signal processing techniques are described for Deep Space Network radios and a proposed receiver architecture is presented, as well as experimental results on this new receiver's analog front end. The receiver's design employs direct downconversion rather than high speed digitization, and it is just as suitable for use as a space based probe relay receiver as it is for installation at a ground antenna. The advantages of having an inexpensive, shoe box size receiver, which could be carried around to antennas of opportunity, used for spacecraft testing or installed in the base of every antenna in a large array are the force behind this project.

  2. Advancing Educational Policy by Advancing Research on Instruction

    ERIC Educational Resources Information Center

    Raudenbush, Stephen W.

    2008-01-01

    Understanding the impact of "instructional regimes" on student learning is central to advancing educational policy. Research on instructional regimes has parallels with clinical trials in medicine yet poses unique challenges because of the social nature of instruction: A child's potential outcome under a given regime depends on peers and teachers,…

  3. Central venous line - infants

    MedlinePlus

    CVL - infants; Central catheter - infants - surgically placed ... plastic tube that is put into a large vein in the chest. WHY IS A ... central catheter (PICC) or midline central catheter (MCC). A CVL ...

  4. TIMMS Advanced 2015 Assessment Frameworks

    ERIC Educational Resources Information Center

    Mullis, Ina V. S., Ed.; Martin, Michael O., Ed.

    2014-01-01

    It is critical for countries to ensure that capable secondary school students receive further preparation in advanced mathematics and science, so that they are ready to enter challenging university-level studies that prepare them for careers in science, technology, engineering, and mathematics (STEM) fields. This group of students will become the…

  5. Advanced Microsensors

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This video looks at a spinoff application of the technology from advanced microsensors -- those that monitor and determine conditions of spacecraft like the Space Shuttle. The application featured is concerned with the monitoring of the health of premature babies.

  6. Advanced Composition

    ERIC Educational Resources Information Center

    Sarantos, R. L.

    1974-01-01

    This is an excerpt from a course for advanced students, designed to teach proficiency in English composition by providing activities specifically geared to the elimination of native language interference. (LG)

  7. Design for On-Sun Evaluation of Evaporator Receivers

    NASA Technical Reports Server (NTRS)

    Jaworske, Donald A.; Colozza, Anthony; Sechkar, Edward A.

    2011-01-01

    A heat pipe designed for operation as a solar power receiver should be optimized to accept the solar energy flux and transfer this heat into a reactor. Optical properties of the surface, thermal conductance of the receiver wall, contact resistance of the heat pipe wick, and other heat pipe wick properties ultimately define the maximum amount of power that can be extracted from the concentrated sunlight impinging on the evaporator surface. Modeling of solar power receivers utilizing optical and physical properties provides guidance to their design. On-sun testing is another important means of gathering information on performance. A test rig is being designed and built to conduct on-sun testing. The test rig is incorporating a composite strip mirror concentrator developed as part of a Small Business Innovative Research effort and delivered to NASA Glenn Research Center. In the strip concentrator numerous, lightweight composite parabolic strips of simple curvature were combined to form an array 1.5 m x 1.5 m in size. The line focus of each strip is superimposed in a central area simulating a point of focus. A test stand is currently being developed to hold the parabolic strip concentrator, track the sun, and turn the beam downward towards the ground. The hardware is intended to be sufficiently versatile to accommodate on-sun testing of several receiver concepts, including those incorporating heat pipe evaporators. Characterization devices are also being developed to evaluate the effectiveness of the solar concentrator, including a receiver designed to conduct calorimetry. This paper describes the design and the characterization devices of the on-sun test rig, and the prospect of coupling the concentrated sunlight to a heat pipe solar power receiver developed as part of another Small Business Innovative Research effort.

  8. Wide-band heterodyne receiver development for effluent measurements

    SciTech Connect

    Hutchinson, D.P.; Richards, R.K.; Simpson, M.L.; Bennett, C.A.; Liu, H.C.; Buchanan, M.

    1998-05-01

    Oak Ridge National Laboratory (ORNL) has been developing advanced infrared heterodyne receivers for plasma diagnostics in fusion reactors for over 20 years. Passive heterodyne radiometry in the LWIR region of the spectrum has historically been restricted by HgCdTe (MCT) detector technology to receiver bandwidths of only 2 GHz. Given typical atmospheric line widths of approximately 3 GHz, a CO{sub 2} (or isotope) laser local oscillator with an average line spacing of 50 GHz, and an MCT detector, only chemical species whose absorptions fall directly on top of laser lines can be measured. Thus, with traditional narrow-band heterodyne radiometry, much of the LWIR spectrum is missed and the less complex direct detection DIAL has been the preferred technique in remote sensing applications. Wide-band heterodyne receivers offer significant improvements in remote measurement capability. Progress at the Institute for Microstructural Sciences (IMS) at National Research Council of Canada and at ORNL in wide-band quantum-well infrared photodetectors (QIPs) and receivers is significantly enhancing the bandwidth capabilities of heterodyne radiometers. ORNL recently made measurements in the lab using QWIPs developed at IMS that demonstrate heterodyne quantum efficiencies of 5% with a heterodyne bandwidth of 7 GHz. The path forward indicates that > 10% heterodyne quantum efficiencies and 30-GHz bandwidths are achievable with current QWIP technology. With a chopped, 30-GHz passive heterodyne receiver, a much larger portion of the LWIR spectrum can now be covered. One potential advantage of wide-band heterodyne receivers for effluent measurements is to dramatically reduce the number of laser lines needed to characterize and distinguish multiple chemical species of interest. In the following paper, the authors discuss this and other implications of these new technologies to the characterization of effluents using both passive heterodyne radiometry and thermo-luminescence.

  9. Integration Window Position Estimation in TR Receivers

    SciTech Connect

    Nekoogar, F; Dowla, F; Spiridon, A

    2005-03-15

    Transmitted-reference (TR) receivers avoid the stringent synchronization requirements that exist in conventional pulse detection schemes. However, the performance of such receivers is highly sensitive to precise timing acquisition and tracking as well as the length of their integration window. This window in TR receivers defines the limits of the finite integrator prior to the final decision making block. In this paper, we propose a novel technique that allows us to extract the timing information of the integration window very accurately in UWB-TR receivers in the presence of channel noise. The principles of the method are presented and the BER performance of a modified UWB-TR receiver is investigated by computer simulation. Our studies show that the proposed estimation technique adds value to the conventional TR receiver structure with modest increase in complexity.

  10. A heat receiver design for solar dynamic space power systems

    NASA Technical Reports Server (NTRS)

    Baker, Karl W.; Dustin, Miles O.; Crane, Roger

    1990-01-01

    An advanced heat pipe receiver designed for a solar dynamic space power system is described. The power system consists of a solar concentrator, solar heat receiver, Stirling heat engine, linear alternator and waste heat radiator. The solar concentrator focuses the sun's energy into a heat receiver. The engine and alternator convert a portion of this energy to electric power and the remaining heat is rejected by a waste heat radiator. Primary liquid metal heat pipes transport heat energy to the Stirling engine. Thermal energy storage allows this power system to operate during the shade portion of an orbit. Lithium fluoride/calcium fluoride eutectic is the thermal energy storage material. Thermal energy storage canisters are attached to the midsection of each heat pipe. The primary heat pipes pass through a secondary vapor cavity heat pipe near the engine and receiver interface. The secondary vapor cavity heat pipe serves three important functions. First, it smooths out hot spots in the solar cavity and provides even distribution of heat to the engine. Second, the event of a heat pipe failure, the secondary heat pipe cavity can efficiently transfer heat from other operating primary heat pipes to the engine heat exchanger of the defunct heat pipe. Third, the secondary heat pipe vapor cavity reduces temperature drops caused by heat flow into the engine. This unique design provides a high level of reliability and performance.

  11. North Central Thailand

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This radar image shows the dramatic landscape in the Phang Hoei Range of north central Thailand, about 40 kilometers (25 miles) northeast of the city of Lom Sak. The plateau, shown in green to the left of center, is the area of Phu Kradung National Park. This plateau is a remnant of a once larger plateau, another portion of which is seen along the right side of the image. The plateaus have been dissected by water erosion over thousands of years. Forest areas appear green on the image; agricultural areas and settlements appear as red and blue. North is toward the lower right. The area shown is 38 by 50 kilometers (24 by 31 miles) and is centered at 16.96 degrees north latitude, 101.67 degrees east longitude. Colors are assigned to different radar frequencies and polarizations as follows: red is L-band horizontally transmitted and horizontally received; green is L-band horizontally transmitted and vertically received; blue is C-band horizontally transmitted and vertically received. The image was acquired by the Spaceborne Imaging Radar-C/X-band Synthetic Aperture (SIR-C/X-SAR) imaging radar on October 3, 1994, when it flew aboard the space shuttle Endeavour. SIR-C/X-SAR is a joint mission of the U.S./German and Italian space agencies.

    Spaceborne Imaging Radar-C and X-Band Synthetic Aperture Radar (SIR-C/X-SAR) is part of NASA's Mission to Planet Earth. The radars illuminate Earth with microwaves allowing detailed observations at any time, regardless of weather or sunlight conditions. SIR-C/X-SAR uses three microwave wavelengths: L-band (24 cm), C-band (6 cm) and X-band (3 cm). The multi-frequency data will be used by the international scientific community to better understand the global environment and how it is changing. The SIR-C/X-SAR data, complemented by aircraft and ground studies, will give scientists clearer insights into those environmental changes which are caused by nature and those changes which are induced by human activity. SIR-C was developed by

  12. RF subsystem design for microwave communication receivers

    NASA Astrophysics Data System (ADS)

    Bickford, W. J.; Brodsky, W. G.

    A system review of the RF subsystems of (IFF) transponders, tropscatter receivers and SATCOM receivers is presented. The quantity potential for S-band and X-band IFF transponders establishes a baseline requirement. From this, the feasibility of a common design for these and other receivers is evaluated. Goals are established for a GaAs MMIC (monolithic microwave integrated circuit) device and related local oscillator preselector and self-test components.

  13. Absolute flux density calibrations: Receiver saturation effects

    NASA Technical Reports Server (NTRS)

    Freiley, A. J.; Ohlson, J. E.; Seidel, B. L.

    1978-01-01

    The effect of receiver saturation was examined for a total power radiometer which uses an ambient load for calibration. Extension to other calibration schemes is indicated. The analysis shows that a monotonic receiver saturation characteristic could cause either positive or negative measurement errors, with polarity depending upon operating conditions. A realistic model of the receiver was made by using a linear-cubic voltage transfer characteristic. The evaluation of measurement error for this model provided a means for correcting radio source measurements.

  14. Costas loop analysis for coherent optical receivers

    NASA Astrophysics Data System (ADS)

    Hodgkinson, T. G.

    1986-03-01

    A homodyne Costas loop receiver is analyzed taking both shot and laser phase noise sources into acount. The reciever performance is compared with that of a heterodyne receiver using an electrical Costas loop and that of a coherent receiver using a pilot carrier phase-locked loop. It is shown that, to avoid large performance penalties, beat linewidth to bit-rate ratios smaller than 0.05 percent and 0.5 percent are needed for PSK homodyne and heterodyne systems, respectively.

  15. Bradford H. Hager Receives 2013 Inge Lehmann Medal: Citation

    NASA Astrophysics Data System (ADS)

    Mitrovica, Jerry X.

    2014-01-01

    In the post-plate tectonics world, efforts to map the structure of Earth's interior broadened to include a growing preoccupation with the underlying dynamics. Students of global geophysics recognize the important role that previous recipients of the Inge Lehmann Medal played in this effort, but they would also understand the reasons that Bradford Hager of the Massachusetts Institute of Technology must be included in this honored list. Brad has been a central figure in mantle dynamics for the last 30 years, responsible for many fundamental advances in our understanding of mantle structure and flow and their connection to the geological record.

  16. False lock performance of quadriphase receivers

    NASA Technical Reports Server (NTRS)

    Simon, M. K.

    1979-01-01

    Quadriphase receivers, like biphase receivers, have the ability to false lock on a sideband on the data modulation. The theory associated with this phenomenon for receivers of binary phase-shift-keying (BPSK), using Costas loop demodulation, has recently been documented in the literature. This paper considers the corresponding theory for receivers of balanced quadriphase-shift-keying (QPSK) employing a quadriphase Costas loop (or equivalent fourth-power loop) for demodulation. Specific closed form expressions for false lock performance are developed and numerically evaluated for the particular case of single pole arm filters and an NRZ data format for each of the two statistically independent quadrature modulations.

  17. Nursing process approach improves receivables management.

    PubMed

    Dias, K; Stockamp, D

    1992-09-01

    The "nursing process" is a systematic decision-making approach to problem solving based on open-system theory. This theory assumes that there is an on-going interchange between all system components. Components cannot be viewed in isolation, because decisions regarding one component will affect other components. Receivables management is similar to the nursing process, in that it involves constant diagnosis, assessment, and intervention in the work in process during all phases of the receivables cycle. In experiments that applied the nursing process concept to the management of accounts receivable in several hospitals, gross days in accounts receivable were reduced and cash flow was increased. PMID:10145682

  18. Receiver psychology turns 20: is it time for a broader approach?

    PubMed

    Miller, Cory T; Bee, Mark A

    2012-02-01

    Twenty years ago, a new conceptual paradigm known as 'receiver psychology' was introduced to explain the evolution of animal communication systems. This paradigm advanced the idea that psychological processes in the receiver's nervous system influence a signal's detectability, discriminability and memorability, and thereby serve as powerful sources of selection shaping signal design. While advancing our understanding of signal diversity, more recent studies make clear that receiver psychology, as a paradigm, has been structured too narrowly and does not incorporate many of the perceptual and cognitive processes of signal reception that operate between sensory transduction and a receiver's response. Consequently, the past two decades of research on receiver psychology have emphasized considerations of signal evolution but failed to ask key questions about the mechanisms of signal reception and their evolution. The primary aim of this essay is to advocate for a broader receiver psychology paradigm that more explicitly includes a research focus on receivers' psychological landscapes. We review recent experimental studies of hearing and sound communication to illustrate how considerations of several general perceptual and cognitive processes will facilitate future research on animal signalling systems. We also emphasize how a rigorous comparative approach to receiver psychology is critical to explicating the full range of perceptual and cognitive processes involved in receiving and responding to signals.

  19. Receiver psychology turns 20: is it time for a broader approach?

    PubMed Central

    Miller, Cory T.; Bee, Mark A.

    2013-01-01

    Twenty years ago, a new conceptual paradigm known as ‘receiver psychology’ was introduced to explain the evolution of animal communication systems. This paradigm advanced the idea that psychological processes in the receiver's nervous system influence a signal's detectability, discriminability and memorability, and thereby serve as powerful sources of selection shaping signal design. While advancing our understanding of signal diversity, more recent studies make clear that receiver psychology, as a paradigm, has been structured too narrowly and does not incorporate many of the perceptual and cognitive processes of signal reception that operate between sensory transduction and a receiver's response. Consequently, the past two decades of research on receiver psychology have emphasized considerations of signal evolution but failed to ask key questions about the mechanisms of signal reception and their evolution. The primary aim of this essay is to advocate for a broader receiver psychology paradigm that more explicitly includes a research focus on receivers' psychological landscapes. We review recent experimental studies of hearing and sound communication to illustrate how considerations of several general perceptual and cognitive processes will facilitate future research on animal signalling systems. We also emphasize how a rigorous comparative approach to receiver psychology is critical to explicating the full range of perceptual and cognitive processes involved in receiving and responding to signals. PMID:24013277

  20. A centralized audio presentation manager

    SciTech Connect

    Papp, A.L. III; Blattner, M.M.

    1994-05-16

    The centralized audio presentation manager addresses the problems which occur when multiple programs running simultaneously attempt to use the audio output of a computer system. Time dependence of sound means that certain auditory messages must be scheduled simultaneously, which can lead to perceptual problems due to psychoacoustic phenomena. Furthermore, the combination of speech and nonspeech audio is examined; each presents its own problems of perceptibility in an acoustic environment composed of multiple auditory streams. The centralized audio presentation manager receives abstract parameterized message requests from the currently running programs, and attempts to create and present a sonic representation in the most perceptible manner through the use of a theoretically and empirically designed rule set.

  1. MRDIS Standalone Central Alarm Station

    2012-09-12

    The MRDIS Standalone Central Alarm Station(MRDIS-CAS} is a software system for receiving, storing, and reviewing radiation data collected by the Mobile Radiation Detection and Identification System (MRDIS}, a mobile radiation scanning system developed for use in foreign ports for the DOE Megaports Initiative. It is designed to run on one of the on board computers in the MRDIS cab. It will collect, store, and display data from the MRDIS without the need for wireless communicationsmore » or centralized server technology. It is intended to be a lightweight replacement for a distributed Megaports communication system in ports where the necessary communications infrastructure does not exist for a full Megaports communications system.« less

  2. Advanced fuel chemistry for advanced engines.

    SciTech Connect

    Taatjes, Craig A.; Jusinski, Leonard E.; Zador, Judit; Fernandes, Ravi X.; Miller, James A.

    2009-09-01

    Autoignition chemistry is central to predictive modeling of many advanced engine designs that combine high efficiency and low inherent pollutant emissions. This chemistry, and especially its pressure dependence, is poorly known for fuels derived from heavy petroleum and for biofuels, both of which are becoming increasingly prominent in the nation's fuel stream. We have investigated the pressure dependence of key ignition reactions for a series of molecules representative of non-traditional and alternative fuels. These investigations combined experimental characterization of hydroxyl radical production in well-controlled photolytically initiated oxidation and a hybrid modeling strategy that linked detailed quantum chemistry and computational kinetics of critical reactions with rate-equation models of the global chemical system. Comprehensive mechanisms for autoignition generally ignore the pressure dependence of branching fractions in the important alkyl + O{sub 2} reaction systems; however we have demonstrated that pressure-dependent 'formally direct' pathways persist at in-cylinder pressures.

  3. Workers' Central Life Interests and Job Performance.

    ERIC Educational Resources Information Center

    Dubin, Robert; Champoux, Joseph E.

    Supervisors' ratings of individual industrial workers appear to be related to the central life interests (CLI) of the workers. The group of workers who had a job-oriented CLI received the highest ratings from their superivsors among the three CLI groups on Initiative and Application, Cooperation and Quantity of Work and were rated low on…

  4. Central cell nuclear-cytoplasmic incongruity:a mechanism for segregation distortion in advanced backcross and selfed generations of (Allium cepa L. x Allium fistulosum L.) x A. cepa interspecific hybrid derivatives.

    PubMed

    Mangum, P D; Peffley, E B

    2005-01-01

    A model is presented as an explanation for an anomaly observed in germination and establishment and isozyme segregation patterns in Allium cepa x A. fistulosum F2BC3 populations generated in an introgression-breeding program. The F1BC3 parent of these populations was selected for its heterozygous PGI phenotype, Pgi-1(2/3); Pgi-1(2) was inherited from an A. cepa (Ac) seed parent and Pgi-1(3) from an A. fistulosum (Af) pollen parent. Germination and establishment was recorded for the F2BC3 progeny population. Segregation of Ac and Af Pgi-1 alleles was investigated in F2BC3 seeds and embryo and endosperm tissue was isolated and tested for isozyme expression. A pooled goodness-of-fit test of the segregation of Pgi-1 alleles in the populations to the expected Mendelian 1:2:1 ratio using the chi-square statistic gave a chi2 = 185.9, well beyond the accepted limits at 2 degrees of freedom. The 1:2:1 ratio expected for simple Mendelian inheritance was rejected, while a pooled chi-square goodness-of-fit test of the segregation of Pgi-1 alleles in the populations fit a 1:1 ratio with a chi2 = 0.203, based on the incongruity model. We present here the central cell nuclear-cytoplasmic incongruity hypothesis to explain the observed anomalies. PMID:15753603

  5. [MANAGEMENT OF CENTRAL HYPERSOMNIAS].

    PubMed

    Dauvilliers, Yves; Lopez, Régis

    2016-06-01

    Central hypersomnias include narcolepsy type 1, type 2 and idiopathic hypersomnia with daytime sleepiness excessive in the foreground of the clinical symptoms. Despite major advances in our understanding of the mechanisms of the narcolepsy type 1 with a low level of hypocretin-1 in cerebrospinal fluid, its current management is only symptomatic. The current management is also only symptomatic for type 2 narcolepsy and idiopathic hypersomnia with an unknown pathophysiology. Treatment options may vary from a single drug targeting several symptoms or several drugs treating a specific symptom. The treatment of daytime sleepiness is based on modafinil in first intention. Other psychostimulants such as methylphenidate, pitolisant and exceptionally dextro-amfetamine may be considered. In narcolepsy type 1, antidepressants such as inhibitors of the reuptake of serotonin and noradrenaline will be considered to improve cataplexy. Sodium oxybate is an effective treatment on sleepiness, cataplexy and bad night sleep in narcolepsy. The management for other symptoms or comorbidities should be considered it necessary such as hallucinations, sleep paralysis, the disturbed nighttime sleep, unpleasant dreams, parasomnias, depressive symptoms, overweight/obesity, cardiovascular disease and obstructive sleep apnea syndrome. Important therapeutic perspectives are to be expected concerning new psychostimulant and anticataplectiques, but mainly on immune-based therapies administered as early as possible after disease onset and on hypocretin replacement therapy for patients with severe symptoms. PMID:27538329

  6. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 7 2013-07-01 2013-07-01 false Air receivers. 1917.155 Section 1917.155 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Related Terminal Operations and Equipment § 1917.155 Air receivers. (a) Application. This section applies to compressed...

  7. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  8. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  9. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  10. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  11. 7 CFR 1230.632 - Receiving ballots.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) Producers. A ballot shall be considered to be received on time if: (1) It was cast in-person in the county...; or (2) It was cast as an absentee ballot, having a postmarked date not later than the last day of the... day of the in-person voting period and was received in the FSA headquarters office in Washington,...

  12. Optimization of MLS receivers for multipath environments

    NASA Technical Reports Server (NTRS)

    Mcalpine, G. A.; Highfill, J. H., III; Irwin, S. H.; Padgett, J. E.

    1975-01-01

    A receiver is designed for aircraft (A/C), which, as a component of the proposed Microwave Landing System (MLS), is capable of optimal performance in the multipath environments found in air terminal areas. Topics discussed include: the angle-tracking problem of the MLS receiver; signal modeling; preliminary approaches to optimal design; suboptimal design; and simulation study.

  13. Liquid cooled fiber thermal radiation receiver

    DOEpatents

    Butler, Barry L.

    1987-01-01

    A radiation-to-thermal receiver apparatus for collecting radiation and converting it to thermal energy is disclosed. The invention includes a fibrous mat material which captures radiation striking the receiver. Captured radiation is removed from the fibrous mat material by a transparent fluid within which the material is bathed.

  14. Liquid cooled fiber thermal radiation receiver

    DOEpatents

    Butler, B.L.

    1985-03-29

    A radiation-to-thermal receiver apparatus for collecting radiation and converting it to thermal energy is disclosed. The invention includes a fibrous mat material which captures radiation striking the receiver. Captured radiation is removed from the fibrous mat material by a transparent fluid within which the material is bathed.

  15. Heat-Energy Analysis for Solar Receivers

    NASA Technical Reports Server (NTRS)

    Lansing, F. L.

    1982-01-01

    Heat-energy analysis program (HEAP) solves general heat-transfer problems, with some specific features that are "custom made" for analyzing solar receivers. Can be utilized not only to predict receiver performance under varying solar flux, ambient temperature and local heat-transfer rates but also to detect locations of hotspots and metallurgical difficulties and to predict performance sensitivity of neighboring component parameters.

  16. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be capable of reception of G3E emission on the navigational frequency...

  17. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be capable of reception of G3E emission on the navigational frequency...

  18. 47 CFR 80.1013 - Receiver.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Radiotelephone Installations Required by the Bridge-to-Bridge Act § 80.1013 Receiver. The bridge-to-bridge receiver must be capable of reception of G3E emission on the navigational frequency...

  19. 17 CFR 256.143 - Accounts receivable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Accounts receivable. 256.143... SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.143 Accounts receivable. This account...

  20. 17 CFR 256.143 - Accounts receivable.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Accounts receivable. 256.143... SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.143 Accounts receivable. This account...

  1. 29 CFR 1910.169 - Air receivers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Compressed Gas and Compressed Air Equipment § 1910.169 Air receivers. (a) General requirements—(1) Application. This section applies to compressed air receivers, and other equipment used in providing and utilizing compressed air for performing operations such as...

  2. 47 CFR 32.1170 - Receivables.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... enable the company to make the following analysis: (1) Amounts due from customers who are receiving... FOR TELECOMMUNICATIONS COMPANIES Instructions for Balance Sheet Accounts § 32.1170 Receivables. (a) This account shall include all amounts due from customers for services rendered or billed and...

  3. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  4. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  5. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  6. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  7. 7 CFR 966.124 - Approved receiver.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TOMATOES GROWN IN FLORIDA Rules and..., as an approved receiver, tomatoes for purposes as set forth in § 966.120(a), shall annually, prior... specified purpose is to occur; (4) Whether or not the receiver packs, repacks or sells fresh tomatoes; (5)...

  8. 29 CFR 1917.155 - Air receivers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... transportation applications as railways, vehicles or cranes. (b) Gauges and valves. (1) Air receivers shall be equipped with indicating pressure gauges and spring-loaded safety valves. Safety valves shall prevent receiver pressure from exceeding 110 percent of the maximum allowable working pressure. (2) No other...

  9. Central blood pressure and chronic kidney disease

    PubMed Central

    Ohno, Yoichi; Kanno, Yoshihiko; Takenaka, Tsuneo

    2016-01-01

    In this review, we focused on the relationship between central blood pressure and chronic kidney diseases (CKD). Wave reflection is a major mechanism that determines central blood pressure in patients with CKD. Recent medical technology advances have enabled non-invasive central blood pressure measurements. Clinical trials have demonstrated that compared with brachial blood pressure, central blood pressure is a stronger risk factor for cardiovascular (CV) and renal diseases. CKD is characterized by a diminished renal autoregulatory ability, an augmented direct transmission of systemic blood pressure to glomeruli, and an increase in proteinuria. Any elevation in central blood pressure accelerates CKD progression. In the kidney, interstitial inflammation induces oxidative stress to handle proteinuria. Oxidative stress facilitates atherogenesis, increases arterial stiffness and central blood pressure, and worsens the CV prognosis in patients with CKD. A vicious cycle exists between CKD and central blood pressure. To stop this cycle, vasodilator antihypertensive drugs and statins can reduce central blood pressure and oxidative stress. Even in early-stage CKD, mineral and bone disorders (MBD) may develop. MBD promotes oxidative stress, arteriosclerosis, and elevated central blood pressure in patients with CKD. Early intervention or prevention seems necessary to maintain vascular health in patients with CKD. PMID:26788468

  10. OMEGA timing receiver, design and system test

    NASA Technical Reports Server (NTRS)

    Wilson, J. J.; Britt, J. E.; Chi, A.

    1972-01-01

    The design of a two frequency OMEGA Timing Receiver is discussed. The receiver tracks the arrival time of the signals by precise phase matching at the receiving antenna. Provision is made for inserting a propagation delay correction for each signal path. Time is measured as the difference between the zero crossing coincidence of the corrected signals and the local time. This number is displayed on the front panel in microseconds. The receiver can also function as a precise phase tracking receiver for collection of propagation data essential to augmenting the propagation corrections. All phase and time information is made available in a BCD format for flexibility in interfacing with other equipment. Results of preliminary tests using experimental transmissions are given. Preliminary results indicate time may be transferred by this technique to an accuracy of a few microseconds.

  11. Oxytocin links mothering received, mothering bestowed and adult stress responses.

    PubMed

    Pedersen, Cort A; Boccia, Maria L

    2002-12-01

    We review recent discoveries that implicate oxytocin in the intergenerational transmission of similar levels of maternal behavior and acute stress responses in female rats. First, ICV-infused oxytocin antagonist decreased the display by nursing dams of pup-licking (PL) and arched-back nursing (ABN), but not other components of maternal behavior, and increased maternal self-grooming suggesting that oxytocin may shift the balance of oral grooming by dams away from themselves and toward pups. Second, oxytocin receptor concentrations in areas of the adult brain where oxytocin stimulates maternal behavior or diminishes anxiety and adrenal axis responses to acute stress were positively related to PL-ABN received during infancy. Third, oxytocin and oxytocin antagonist treatments of pups on postnatal days 2-10, respectively increased and decreased PL by the treated rats when adult and themselves nursing dams. This indicates that oxytocin activity in female pups, which may be regulated by PL-ABN received from their mothers, influences their adult levels of PL. These three lines of evidence suggest that oxytocin selectively enhances PL-ABN by rat dams, which then increases oxytocin activity in female pups and, thereby, facilitates their expression of central oxytocin receptors (and perhaps other aspects of central oxytocin systems) and, consequently, their adult PL-ABN frequencies and acute stress responses.

  12. The DPC-2000 advanced control system for the Dynamitron accelerator

    NASA Astrophysics Data System (ADS)

    Kestler, Bernard A.; Lisanti, Thomas F.

    1993-07-01

    The DPC-2000 is an advanced control system utilizing the latest technology in computer control circuitry and components. Its overall design is modular and technologically advanced to keep up with customer and engineering demands. The full control system is presented as four units. They are the Remote I/O (Input / Output), Local Analog and Digital I/O, Operator Interface and the Main Computer. The central processing unit, the heart of the system, executes a high level language program that communicates to the different sub-assemblies through advanced serial and parallel communication lines. All operational parameters of the accelerator are monitored, controlled and corrected at close to 20 times per second. The operator is provided with a selection of many informative screen displays. The control program handles all graphic screen displays and the updating of these screens directly; it does not have to communicate to a display terminal. This adds to the quick response and excellent operator feedback received while operating the machine. The CPU also has the ability to store and record all process variable setpoints for each product that will be treated. This allows the operator to set up the process parameters by selecting the product identification code from a menu presented on the display screen. All process parameters are printed to report at regular intervals during a process run for later analysis and record keeping.

  13. A direct advance on advance directives.

    PubMed

    Shaw, David

    2012-06-01

    Advance directives (ADs), which are also sometimes referred to as 'living wills', are statements made by a person that indicate what treatment she should not be given in the event that she is not competent to consent or refuse at the future moment in question. As such, ADs provide a way for patients to make decisions in advance about what treatments they do not want to receive, without doctors having to find proxy decision-makers or having recourse to the doctrine of necessity. While patients can request particular treatments in an AD, only refusals are binding. This paper will examine whether ADs safeguard the autonomy and best interests of the incompetent patient, and whether legislating for the use of ADs is justified, using the specific context of the legal situation in the United Kingdom to illustrate the debate. The issue of whether the law should permit ADs is itself dependent on the issue of whether ADs are ethically justified; thus we must answer a normative question in order to answer the legislative one. It emerges that ADs suffer from two major problems, one related to autonomy and one to consent. First, ADs' emphasis on precedent autonomy effectively sentences some people who want to live to death. Second, many ADs might not meet the standard criteria for informed refusal of treatment, because they fail on the crucial criterion of sufficient information. Ultimately, it transpires that ADs are typically only appropriate for patients who temporarily lose physical or mental capacity.

  14. Eye Movement Correlates of Acquired Central Dyslexia

    ERIC Educational Resources Information Center

    Schattka, Kerstin I.; Radach, Ralph; Huber, Walter

    2010-01-01

    Based on recent progress in theory and measurement techniques, the analysis of eye movements has become one of the major methodological tools in experimental reading research. Our work uses this approach to advance the understanding of impaired information processing in acquired central dyslexia of stroke patients with aphasia. Up to now there has…

  15. Mesoscale oceanic response to wind events off central California in spring 1989: CTD surveys and AVHRR imagery. [Conductivity/temperature/depth surveys; Selected Advanced Very High Resolution Radiometer satellite imaging

    SciTech Connect

    Schwing, F.B.; Husby, D.M. ); Garfield, N.; Tracy, D.E. )

    1991-11-01

    Analysis of hydrographic data obtained during juvenile groundfish surveys, in relation to local wind forcing and AVHRR sea-surface temperature imagery, reveals that the oceanic region off central California between Point Reyes and Point Sur in spring 1989 was characterized by complex circulation patterns and considerable temporal and mesoscale variability. The 'spring transition' to upwelling-favorable winds is most clearly evidenced by rapid, large decreases in SST (up to 4-5C) measured at four meteorological buoys. Daily-averaged winds are spatially coherent and oscillate between upwelling-favorable and relaxation conditions at 3-10-day intervals. Persistent upwelling centers near Point Reyes and Point Ano Nuevo were characterized by relatively cool, salty (8-10C, 33.6-34.0 psu) water in the upper 50 m, which is derived from offshore water at depths of 50-100 m. Water-mass analysis reveals that upwelled water is advected equatorward from its source. Some upwelled water is transported into shallow coastal areas and warmed. Alongshelf fronts between relatively warm, low-salinity ([gt]13C, [lt]33.5 psu) offshore water and cool, higher-salinity upwelled water are advected onshore in response to wind relaxation or reversal events: frontal gradients intensify at these times. AVHRR imagery verifies the spatial patterns and complex mesoscale variability of the near-surface patterns observed in the CTD survey data. Eddylike hydrographic features are noted with horizontal scales on the order of the station spacing (10 km). How the complex circulation patterns and intense mesoscale spatial and temporal variability affect the survival and subsequent recruitment of juvenile groundfish is discussed.

  16. Cyclic frictional-viscous slip oscillations along the base of an advancing nappe complex: Insights into brittle-ductile nappe emplacement mechanisms from the Naukluft Nappe Complex, central Namibia

    NASA Astrophysics Data System (ADS)

    Viola, Giulio; Mancktelow, Neil S.; Miller, Jodie A.

    2006-06-01

    The Naukluft Nappe Complex (NNC) forms a far-traveled fold and thrust belt klippe of the Panafrican Damara Belt in central Namibia. Estimates of the SE directed displacement range between 50 and 80 km. The entire nappe stack was thrust along an out-of-sequence, nearly planar, horizontal structure, the "Naukluft Thrust." The thrust zone consists of several distinct lithological components whose typical distribution, when all present, from bottom to top is (1) a massive, ochre-yellow weathering dolomite; (2) a polymict "gritty dolomite" (called in the past "Sole Dolomite"), (3) strongly foliated and isoclinally folded calcmylonites, and (4) an upper massive dolomite. A very discrete (<50 mm thick, often <10 mm thick) planar brittle fault (component 5) can occur at any level within this sequence. Our investigations show that the gritty dolomite forms by progressive cataclasis of the massive dolomite (component 1). Moreover, clasts of gritty dolomite are observed randomly oriented within a similar gritty dolomite matrix, suggesting multiple pulses of brecciation and self-brecciation. The gritty dolomite locally forms injection veins into the calcmylonites, and these veins are themselves boudinaged, indicating broadly coeval cataclastic and ductile deformation. The evolution of structures within the thrust zone is linked to the presence and flow of overpressured pore fluids. Field observations suggest that several pulses of fluid-induced brittle deformation overprinted, in a cyclic fashion, ductile structures formed during the emplacement of the nappe edifice. A "fault valve" behavior is suggested for the basal detachment of the NNC, with bulk shortening being accommodated by incremental slip during a history of combined viscous and frictional flow.

  17. Technological Advancements

    ERIC Educational Resources Information Center

    Kennedy, Mike

    2010-01-01

    The influx of technology has brought significant improvements to school facilities. Many of those advancements can be found in classrooms, but when students head down the hall to use the washrooms, they are likely to find a host of technological innovations that have improved conditions in that part of the building. This article describes modern…

  18. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2004-01-01

    Research advances, a new feature in Journal of Chemical Engineering that brings information about innovations in current areas of research to high school and college science faculty with an intent to provide educators with timely descriptions of latest progress in research that can be integrated into existing courses to update course content and…

  19. Temperature influences in receiver clock modelling

    NASA Astrophysics Data System (ADS)

    Wang, Kan; Meindl, Michael; Rothacher, Markus; Schoenemann, Erik; Enderle, Werner

    2016-04-01

    In Precise Point Positioning (PPP), hardware delays at the receiver site (receiver, cables, antenna, …) are always difficult to be separated from the estimated receiver clock parameters. As a result, they are partially or fully contained in the estimated "apparent" clocks and will influence the deterministic and stochastic modelling of the receiver clock behaviour. In this contribution, using three years of data, the receiver clock corrections of a set of high-precision Hydrogen Masers (H-Masers) connected to stations of the ESA/ESOC network and the International GNSS Service (IGS) are firstly characterized concerning clock offsets, drifts, modified Allan deviations and stochastic parameters. In a second step, the apparent behaviour of the clocks is modelled with the help of a low-order polynomial and a known temperature coefficient (Weinbach, 2013). The correlations between the temperature and the hardware delays generated by different types of antennae are then analysed looking at daily, 3-day and weekly time intervals. The outcome of these analyses is crucial, if we intend to model the receiver clocks in the ground station network to improve the estimation of station-related parameters like coordinates, troposphere zenith delays and ambiguities. References: Weinbach, U. (2013) Feasibility and impact of receiver clock modeling in precise GPS data analysis. Dissertation, Leibniz Universität Hannover, Germany.

  20. The Los Alamos beacon receiver array

    SciTech Connect

    Carlos, R.C.; Massey, R.S. )

    1994-07-01

    The authors are interested in studying both the natural background of acoustic and acoustic-gravity waves, for which the sources are not generally known, as well as waves produced by known sources such as large explosions and launches of large rockets. The authors describe radio receivers that monitor transmissions from beacons on geosynchronous satellites. The receivers can detect perturbations of a 300--3,000 s period in the electron density integrated from beacon to receiver, for amplitudes as low as (1--2) [times] 10[sup 13] m[sup [minus]2]. Data are used in studies of atmospheric acoustic and acoustic-gravity waves.