Advances in Antibody Design

PubMed Central

Tiller, Kathryn E.; Tessier, Peter M.

2017-01-01

The use of monoclonal antibodies as therapeutics requires optimizing several of their key attributes. These include binding affinity and specificity, folding stability, solubility, pharmacokinetics, effector functions, and compatibility with the attachment of additional antibody domains (bispecific antibodies) and cytotoxic drugs (antibody–drug conjugates). Addressing these and other challenges requires the use of systematic design methods that complement powerful immunization and in vitro screening methods. We review advances in designing the binding loops, scaffolds, domain interfaces, constant regions, post-translational and chemical modifications, and bispecific architectures of antibodies and fragments thereof to improve their bioactivity. We also highlight unmet challenges in antibody design that must be overcome to generate potent antibody therapeutics. PMID:26274600

Application of advanced multidisciplinary analysis and optimization methods to vehicle design synthesis

NASA Technical Reports Server (NTRS)

Consoli, Robert David; Sobieszczanski-Sobieski, Jaroslaw

1990-01-01

Advanced multidisciplinary analysis and optimization methods, namely system sensitivity analysis and non-hierarchical system decomposition, are applied to reduce the cost and improve the visibility of an automated vehicle design synthesis process. This process is inherently complex due to the large number of functional disciplines and associated interdisciplinary couplings. Recent developments in system sensitivity analysis as applied to complex non-hierarchic multidisciplinary design optimization problems enable the decomposition of these complex interactions into sub-processes that can be evaluated in parallel. The application of these techniques results in significant cost, accuracy, and visibility benefits for the entire design synthesis process.

Design and Effects of Scenario Educational Software.

ERIC Educational Resources Information Center

Keegan, Mark

1993-01-01

Describes the development of educational computer software called scenario software that was designed to incorporate advances in cognitive, affective, and physiological research. Instructional methods are outlined; the need to change from didactic methods to discovery learning is explained; and scenario software design features are discussed. (24…

Application of advanced control techniques to aircraft propulsion systems

NASA Technical Reports Server (NTRS)

Lehtinen, B.

1984-01-01

Two programs are described which involve the application of advanced control techniques to the design of engine control algorithms. Multivariable control theory is used in the F100 MVCS (multivariable control synthesis) program to design controls which coordinate the control inputs for improved engine performance. A systematic method for handling a complex control design task is given. Methods of analytical redundancy are aimed at increasing the control system reliability. The F100 DIA (detection, isolation, and accommodation) program, which investigates the uses of software to replace or augment hardware redundancy for certain critical engine sensor, is described.

Increase in counselling communication skills after basic and advanced microskills training.

PubMed

Kuntze, Jeroen; van der Molen, Henk T; Born, Marise P

2009-03-01

Mastering counselling communication skills is one of the requirements that lead to the diploma of a registered European psychologist. The microcounseling method proves to be effective in training these skills. Research into the effectiveness of the microcounseling method often reports overall effect sizes only. The aim of this study was to investigate the adequate use of separate counselling communication skills (seven basic skills: minimal encouragements; asking questions; paraphrasing; reflection of feeling; concreteness; summarizing; and situation clarification and five advanced skills: advanced accurate empathy; confrontation; positive relabelling; examples of one's own; and directness) after respectively a basic and an advanced training in these skills. Participants were 583 first year or second year bachelor students in psychology who took the counselling communication skills progress test (CSPT). The participants are divided in a group of freshmen, who had not received any training in counselling communication skills; first year students, who had received a training in basic skills; second year students who had followed a training in advanced skills and a control group. A between-subject design, a within-subject design and a pre-test-post-test-control group design were used to examine the scores on these skills. Seven basic skills and four advanced skills had large effect sizes. One advanced skill had a moderate effect size. The microcounseling method is very effective on the level of separate microskills. However, students perform better on the basic skills than on the advanced skills. More training seems to be needed in the latter to achieve the same level of mastery.

FAA/NASA International Symposium on Advanced Structural Integrity Methods for Airframe Durability and Damage Tolerance, part 2

NASA Technical Reports Server (NTRS)

Harris, Charles E. (Editor)

1994-01-01

The international technical experts in the areas of durability and damage tolerance of metallic airframe structures were assembled to present and discuss recent research findings and the development of advanced design and analysis methods, structural concepts, and advanced materials. The principal focus of the symposium was on the dissemination of new knowledge and the peer-review of progress on the development of advanced methodologies. Papers were presented on the following topics: structural concepts for enhanced durability, damage tolerance, and maintainability; new metallic alloys and processing technology; fatigue crack initiation and small crack effects; fatigue crack growth models; fracture mechanics failure criteria for ductile materials; structural mechanics methodology for residual strength and life prediction; development of flight load spectra for design and testing; and corrosion resistance.

Verification and Validation Process for Progressive Damage and Failure Analysis Methods in the NASA Advanced Composites Consortium

NASA Technical Reports Server (NTRS)

Wanthal, Steven; Schaefer, Joseph; Justusson, Brian; Hyder, Imran; Engelstad, Stephen; Rose, Cheryl

2017-01-01

The Advanced Composites Consortium is a US Government/Industry partnership supporting technologies to enable timeline and cost reduction in the development of certified composite aerospace structures. A key component of the consortium's approach is the development and validation of improved progressive damage and failure analysis methods for composite structures. These methods will enable increased use of simulations in design trade studies and detailed design development, and thereby enable more targeted physical test programs to validate designs. To accomplish this goal with confidence, a rigorous verification and validation process was developed. The process was used to evaluate analysis methods and associated implementation requirements to ensure calculation accuracy and to gage predictability for composite failure modes of interest. This paper introduces the verification and validation process developed by the consortium during the Phase I effort of the Advanced Composites Project. Specific structural failure modes of interest are first identified, and a subset of standard composite test articles are proposed to interrogate a progressive damage analysis method's ability to predict each failure mode of interest. Test articles are designed to capture the underlying composite material constitutive response as well as the interaction of failure modes representing typical failure patterns observed in aerospace structures.

Unsteady Loss in the Stator Due to the Incoming Rotor Wake in a Highly-Loaded Transonic Compressor

NASA Technical Reports Server (NTRS)

Hah, Chunill

2015-01-01

The present paper reports an investigation of unsteady loss generation in the stator due to the incoming rotor wake in an advanced GE transonic compressor design with a high-fidelity numerical method. This advanced compressor with high reaction and high stage loading has been investigated both experimentally and analytically in the past. The measured efficiency in this advanced compressor is significantly lower than the design intention goal. The general understanding is that the current generation of compressor design analysis tools miss some important flow physics in this modern compressor design. To pinpoint the source of the efficiency miss, an advanced test with a detailed flow traverse was performed for the front one and a half stage at the NASA Glenn Research Center.

Application of holographic interferometry for analysis of the dynamic and modal characteristics of an advanced exotic metal airfoil structure

NASA Astrophysics Data System (ADS)

Fein, Howard

1999-03-01

Holographic Interferometry has been successfully employed to characterize the materials and behavior of diverse types of structures under stress. Specialized variations of this technology have also been applied to define dynamic and vibration related structural behavior. Such applications of holographic technique offer some of the most effective methods of modal and dynamic analysis available. Real-time dynamic testing of the modal and mechanical behavior of aerodynamic control and airfoil structures for advanced aircraft has always required advanced instrumentation for data collection in either actual flight test or wind-tunnel simulations. Advanced optical holography techniques are alternate methods which result in actual full-field behavioral data on the ground in a noninvasive environment. These methods offer significant insight in both the development and subsequent operational test and modeling of advanced exotic metal control structures and their integration with total vehicle system dynamics. Structures and materials can be analyzed with very low amplitude excitation and the resultant data can be used to adjust the accuracy mathematically derived structural and behavioral models. Holographic Interferometry offers a powerful tool to aid in the developmental engineering of exotic metal structures for high stress applications. Advanced Titanium alloy is a significant example of these sorts of materials which has found continually increased use in advanced aerodynamic, undersea, and other highly mobil platforms. Aircraft applications in particular must consider environments where extremes in vibration and impulsive mechanical stress can affect both operation and structural stability. These considerations present ideal requisites for analysis using advanced holographic methods in the initial design and test of structures made with such advanced materials. Holographic techniques are nondestructive, real- time, and definitive in allowing the identification of vibrational modes, displacements, and motion geometries. Such information can be crucial to the determination of mechanical configurations and designs as well as operational parameters of structural components fabricated from advanced and exotic materials. Anomalous behavioral characteristics can be directly related to hidden structural or mounting anomalies and defects. Deriving such information can be crucial to the determination of mechanical configurations and designs, as well as critical operational parameters of structural components fabricated from advanced and exotic materials.

Recent Trends in Advance Directives at Nursing Home Admission and One Year after Admission

ERIC Educational Resources Information Center

McAuley, William J.; Buchanan, Robert J.; Travis, Shirley S.; Wang, Suojin; Kim, MyungSuk

2006-01-01

Purpose: Advance directives are important planning and decision-making tools for individuals in nursing homes. Design and Methods: By using the nursing facility Minimum Data Set, we examined the prevalence of advance directives at admission and 12 months post-admission. Results: The prevalence of having any advance directive at admission declined…

Study of metallic structural design concepts for an arrow wing supersonic cruise configuration

NASA Technical Reports Server (NTRS)

Turner, M. J.; Grande, D. L.

1977-01-01

A structural design study was made, to assess the relative merits of various metallic structural concepts and materials for an advanced supersonic aircraft cruising at Mach 2.7. Preliminary studies were made to ensure compliance of the configuration with general design criteria, integrate the propulsion system with the airframe, select structural concepts and materials, and define an efficient structural arrangement. An advanced computerized structural design system was used, in conjunction with a relatively large, complex finite element model, for detailed analysis and sizing of structural members to satisfy strength and flutter criteria. A baseline aircraft design was developed for assessment of current technology. Criteria, analysis methods, and results are presented. The effect on design methods of using the computerized structural design system was appraised, and recommendations are presented concerning further development of design tools, development of materials and structural concepts, and research on basic technology.

Manufacturing development of DC-10 advanced rudder

NASA Technical Reports Server (NTRS)

Cominsky, A.

1979-01-01

The design, manufacture, and ground test activities during development of production methods for an advanced composite rudder for the DC-10 transport aircraft are described. The advanced composite aft rudder is satisfactory for airline service and a cost saving in a full production manufacturing mode is anticipated.

Graphite/Polyimide Composites. [conference on Composites for Advanced Space Transportation Systems

NASA Technical Reports Server (NTRS)

Dexter, H. B. (Editor); Davis, J. G., Jr. (Editor)

1979-01-01

Technology developed under the Composites for Advanced Space Transportation System Project is reported. Specific topics covered include fabrication, adhesives, test methods, structural integrity, design and analysis, advanced technology developments, high temperature polymer research, and the state of the art of graphite/polyimide composites.

Cost estimating methods for advanced space systems

NASA Technical Reports Server (NTRS)

Cyr, Kelley

1988-01-01

The development of parametric cost estimating methods for advanced space systems in the conceptual design phase is discussed. The process of identifying variables which drive cost and the relationship between weight and cost are discussed. A theoretical model of cost is developed and tested using a historical data base of research and development projects.

Co-Designing and Co-Teaching Graduate Qualitative Methods: An Innovative Ethnographic Workshop Model

ERIC Educational Resources Information Center

Cordner, Alissa; Klein, Peter T.; Baiocchi, Gianpaolo

2012-01-01

This article describes an innovative collaboration between graduate students and a faculty member to co-design and co-teach a graduate-level workshop-style qualitative methods course. The goal of co-designing and co-teaching the course was to involve advanced graduate students in all aspects of designing a syllabus and leading class discussions in…

Three-dimensional viscous design methodology for advanced technology aircraft supersonic inlet systems

NASA Technical Reports Server (NTRS)

Anderson, B. H.

1983-01-01

A broad program to develop advanced, reliable, and user oriented three-dimensional viscous design techniques for supersonic inlet systems, and encourage their transfer into the general user community is discussed. Features of the program include: (1) develop effective methods of computing three-dimensional flows within a zonal modeling methodology; (2) ensure reasonable agreement between said analysis and selective sets of benchmark validation data; (3) develop user orientation into said analysis; and (4) explore and develop advanced numerical methodology.

GLOBECOM '86 - Global Telecommunications Conference, Houston, TX, Dec. 1-4, 1986, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

Papers are presented on local area networks; formal methods for communication protocols; computer simulation of communication systems; spread spectrum and coded communications; tropical radio propagation; VLSI for communications; strategies for increasing software productivity; multiple access communications; advanced communication satellite technologies; and spread spectrum systems. Topics discussed include Space Station communication and tracking development and design; transmission networks; modulation; data communications; computer network protocols and performance; and coding and synchronization. Consideration is given to free space optical communications systems; VSAT communication networks; network topology design; advances in adaptive filtering echo cancellation and adaptive equalization; advanced signal processing for satellite communications; the elements, design, and analysis of fiber-optic networks; and advances in digital microwave systems.

Analytical study of interior noise control by fuselage design techniques on high-speed, propeller-driven aircraft

NASA Technical Reports Server (NTRS)

Revell, J. D.; Balena, F. J.; Koval, L. R.

1980-01-01

The acoustical treatment mass penalties required to achieve an interior noise level of 80 dBA for high speed, fuel efficient propfan-powered aircraft are determined. The prediction method used is based on theory developed for the outer shell dynamics, and a modified approach for add-on noise control element performance. The present synthesis of these methods is supported by experimental data. Three different sized aircraft are studied, including a widebody, a narrowbody and a business sized aircraft. Noise control penalties are calculated for each aircraft for two kinds of noise control designs: add-on designs, where the outer wall structure cannot be changed, and advanced designs where the outer wall stiffness level and the materials usage can be altered. For the add-on designs, the mass penalties range from 1.7 to 2.4 percent of the takeoff gross weight (TOGW) of the various aircraft, similar to preliminary estimates. Results for advanced designs show significant reductions of the mass penalties. For the advanced aluminum designs the penalties are 1.5% of TOGW, and for an all composite aircraft the penalties range from 0.74 to 1.4% of TOGW.

DRS: Derivational Reasoning System

NASA Technical Reports Server (NTRS)

Bose, Bhaskar

1995-01-01

The high reliability requirements for airborne systems requires fault-tolerant architectures to address failures in the presence of physical faults, and the elimination of design flaws during the specification and validation phase of the design cycle. Although much progress has been made in developing methods to address physical faults, design flaws remain a serious problem. Formal methods provides a mathematical basis for removing design flaws from digital systems. DRS (Derivational Reasoning System) is a formal design tool based on advanced research in mathematical modeling and formal synthesis. The system implements a basic design algebra for synthesizing digital circuit descriptions from high level functional specifications. DRS incorporates an executable specification language, a set of correctness preserving transformations, verification interface, and a logic synthesis interface, making it a powerful tool for realizing hardware from abstract specifications. DRS integrates recent advances in transformational reasoning, automated theorem proving and high-level CAD synthesis systems in order to provide enhanced reliability in designs with reduced time and cost.

Innovative and Advanced Coupled Neutron Transport and Thermal Hydraulic Method (Tool) for the Design, Analysis and Optimization of VHTR/NGNP Prismatic Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rahnema, Farzad; Garimeela, Srinivas; Ougouag, Abderrafi

2013-11-29

This project will develop a 3D, advanced coarse mesh transport method (COMET-Hex) for steady- state and transient analyses in advanced very high-temperature reactors (VHTRs). The project will lead to a coupled neutronics and thermal hydraulic (T/H) core simulation tool with fuel depletion capability. The computational tool will be developed in hexagonal geometry, based solely on transport theory without (spatial) homogenization in complicated 3D geometries. In addition to the hexagonal geometry extension, collaborators will concurrently develop three additional capabilities to increase the code’s versatility as an advanced and robust core simulator for VHTRs. First, the project team will develop and implementmore » a depletion method within the core simulator. Second, the team will develop an elementary (proof-of-concept) 1D time-dependent transport method for efficient transient analyses. The third capability will be a thermal hydraulic method coupled to the neutronics transport module for VHTRs. Current advancements in reactor core design are pushing VHTRs toward greater core and fuel heterogeneity to pursue higher burn-ups, efficiently transmute used fuel, maximize energy production, and improve plant economics and safety. As a result, an accurate and efficient neutron transport, with capabilities to treat heterogeneous burnable poison effects, is highly desirable for predicting VHTR neutronics performance. This research project’s primary objective is to advance the state of the art for reactor analysis.« less

Introduction to special section of the Journal of Family Psychology, advances in mixed methods in family psychology: integrative and applied solutions for family science.

PubMed

Weisner, Thomas S; Fiese, Barbara H

2011-12-01

Mixed methods in family psychology refer to the systematic integration of qualitative and quantitative techniques to represent family processes and settings. Over the past decade, significant advances have been made in study design, analytic strategies, and technological support (such as software) that allow for the integration of quantitative and qualitative methods and for making appropriate inferences from mixed methods. This special section of the Journal of Family Psychology illustrates how mixed methods may be used to advance knowledge in family science through identifying important cultural differences in family structure, beliefs, and practices, and revealing patterns of family relationships to generate new measurement paradigms and inform clinical practice. Guidance is offered to advance mixed methods research in family psychology through sound principles of peer review.

Integrated design of structures, controls, and materials

NASA Technical Reports Server (NTRS)

Blankenship, G. L.

1994-01-01

In this talk we shall discuss algorithms and CAD tools for the design and analysis of structures for high performance applications using advanced composite materials. An extensive mathematical theory for optimal structural (e.g., shape) design was developed over the past thirty years. Aspects of this theory have been used in the design of components for hypersonic vehicles and thermal diffusion systems based on homogeneous materials. Enhancement of the design methods to include optimization of the microstructure of the component is a significant innovation which can lead to major enhancements in component performance. Our work is focused on the adaptation of existing theories of optimal structural design (e.g., optimal shape design) to treat the design of structures using advanced composite materials (e.g., fiber reinforced, resin matrix materials). In this talk we shall discuss models and algorithms for the design of simple structures from composite materials, focussing on a problem in thermal management. We shall also discuss methods for the integration of active structural controls into the design process.

Recent Advances and Current Trends in Metamaterial-by-Design

NASA Astrophysics Data System (ADS)

Anselmi, N.; Gottardi, G.

2018-02-01

Thanks to their potential applications in several engineering areas, metamaterials gained much of attentions among different research communities, leading to the development of several analysis and synthesis tools. In this context, the metamaterial-by-design (MbD) paradigm has been recently introduced as a powerful tool for the design of complex metamaterials-based structures. In this work a review of the state-of-art, as well as the recent advancements of MbD-based methods are presented.

Double Linear Damage Rule for Fatigue Analysis

NASA Technical Reports Server (NTRS)

Halford, G.; Manson, S.

1985-01-01

Double Linear Damage Rule (DLDR) method for use by structural designers to determine fatigue-crack-initiation life when structure subjected to unsteady, variable-amplitude cyclic loadings. Method calculates in advance of service how many loading cycles imposed on structural component before macroscopic crack initiates. Approach eventually used in design of high performance systems and incorporated into design handbooks and codes.

Mechanistic Indicators of Childhood Asthma (MICA): piloting an integrative design for evaluating environmental health

EPA Science Inventory

Background: Modem methods in molecular biology and advanced computational tools show promise in elucidating complex interactions that occur between genes and environmental factors in diseases such as asthma; however appropriately designed studies are critical for these methods to...

OpenMDAO: Framework for Flexible Multidisciplinary Design, Analysis and Optimization Methods

NASA Technical Reports Server (NTRS)

Heath, Christopher M.; Gray, Justin S.

2012-01-01

The OpenMDAO project is underway at NASA to develop a framework which simplifies the implementation of state-of-the-art tools and methods for multidisciplinary design, analysis and optimization. Foremost, OpenMDAO has been designed to handle variable problem formulations, encourage reconfigurability, and promote model reuse. This work demonstrates the concept of iteration hierarchies in OpenMDAO to achieve a flexible environment for supporting advanced optimization methods which include adaptive sampling and surrogate modeling techniques. In this effort, two efficient global optimization methods were applied to solve a constrained, single-objective and constrained, multiobjective version of a joint aircraft/engine sizing problem. The aircraft model, NASA's nextgeneration advanced single-aisle civil transport, is being studied as part of the Subsonic Fixed Wing project to help meet simultaneous program goals for reduced fuel burn, emissions, and noise. This analysis serves as a realistic test problem to demonstrate the flexibility and reconfigurability offered by OpenMDAO.

A Web Centric Architecture for Deploying Multi-Disciplinary Engineering Design Processes

NASA Technical Reports Server (NTRS)

Woyak, Scott; Kim, Hongman; Mullins, James; Sobieszczanski-Sobieski, Jaroslaw

2004-01-01

There are continuous needs for engineering organizations to improve their design process. Current state of the art techniques use computational simulations to predict design performance, and optimize it through advanced design methods. These tools have been used mostly by individual engineers. This paper presents an architecture for achieving results at an organization level beyond individual level. The next set of gains in process improvement will come from improving the effective use of computers and software within a whole organization, not just for an individual. The architecture takes advantage of state of the art capabilities to produce a Web based system to carry engineering design into the future. To illustrate deployment of the architecture, a case study for implementing advanced multidisciplinary design optimization processes such as Bi-Level Integrated System Synthesis is discussed. Another example for rolling-out a design process for Design for Six Sigma is also described. Each example explains how an organization can effectively infuse engineering practice with new design methods and retain the knowledge over time.

A novel approach of ensuring layout regularity correct by construction in advanced technologies

NASA Astrophysics Data System (ADS)

Ahmed, Shafquat Jahan; Vaderiya, Yagnesh; Gupta, Radhika; Parthasarathy, Chittoor; Marin, Jean-Claude; Robert, Frederic

2017-03-01

In advanced technology nodes, layout regularity has become a mandatory prerequisite to create robust designs less sensitive to variations in manufacturing process in order to improve yield and minimizing electrical variability. In this paper we describe a method for designing regular full custom layouts based on design and process co-optimization. The method includes various design rule checks that can be used on-the-fly during leaf-cell layout development. We extract a Layout Regularity Index (LRI) from the layouts based on the jogs, alignments and pitches used in the design for any given metal layer. Regularity Index of a layout is the direct indicator of manufacturing yield and is used to compare the relative health of different layout blocks in terms of process friendliness. The method has been deployed for 28nm and 40nm technology nodes for Memory IP and is being extended to other IPs (IO, standard-cell). We have quantified the gain of layout regularity with the deployed method on printability and electrical characteristics by process-variation (PV) band simulation analysis and have achieved up-to 5nm reduction in PV band.

Computer Aided Enzyme Design and Catalytic Concepts

PubMed Central

Frushicheva, Maria P.; Mills, Matthew J. L.; Schopf, Patrick; Singh, Manoj K.; Warshel, Arieh

2014-01-01

Gaining a deeper understanding of enzyme catalysis is of great practical and fundamental importance. Over the years it has become clear that despite advances made in experimental mutational studies, a quantitative understanding of enzyme catalysis will not be possible without the use of computer modeling approaches. While we believe that electrostatic preorganization is by far the most important catalytic factor, convincing the wider scientific community of this may require the demonstration of effective rational enzyme design. Here we make the point that the main current advances in enzyme design are basically advances in directed evolution and that computer aided enzyme design must involve approaches that can reproduce catalysis in well-defined test cases. Such an approach is provided by the empirical valence bond method. PMID:24814389

Development of advanced lightweight containment systems

NASA Technical Reports Server (NTRS)

Stotler, C.

1981-01-01

Parametric type data were obtained on advanced lightweight containment systems. These data were used to generate design methods and procedures necessary for the successful development of such systems. The methods were then demonstrated through the design of a lightweight containment system for a CF6 size engine. The containment concept evaluated consisted basically of a lightweight structural sandwich shell wrapped with dry Kevlar cloth. The initial testing was directed towards the determination of the amount of Kevlar required to result in threshold containment for a specific set of test conditions. A relationship was then developed between the thickness required and the energy of the released blade so that the data could be used to design for conditions other than those tested.

Aerodynamic Design Study of Advanced Multistage Axial Compressor

NASA Technical Reports Server (NTRS)

Larosiliere, Louis M.; Wood, Jerry R.; Hathaway, Michael D.; Medd, Adam J.; Dang, Thong Q.

2002-01-01

As a direct response to the need for further performance gains from current multistage axial compressors, an investigation of advanced aerodynamic design concepts that will lead to compact, high-efficiency, and wide-operability configurations is being pursued. Part I of this report describes the projected level of technical advancement relative to the state of the art and quantifies it in terms of basic aerodynamic technology elements of current design systems. A rational enhancement of these elements is shown to lead to a substantial expansion of the design and operability space. Aerodynamic design considerations for a four-stage core compressor intended to serve as a vehicle to develop, integrate, and demonstrate aerotechnology advancements are discussed. This design is biased toward high efficiency at high loading. Three-dimensional blading and spanwise tailoring of vector diagrams guided by computational fluid dynamics (CFD) are used to manage the aerodynamics of the high-loaded endwall regions. Certain deleterious flow features, such as leakage-vortex-dominated endwall flow and strong shock-boundary-layer interactions, were identified and targeted for improvement. However, the preliminary results were encouraging and the front two stages were extracted for further aerodynamic trimming using a three-dimensional inverse design method described in part II of this report. The benefits of the inverse design method are illustrated by developing an appropriate pressure-loading strategy for transonic blading and applying it to reblade the rotors in the front two stages of the four-stage configuration. Multistage CFD simulations based on the average passage formulation indicated an overall efficiency potential far exceeding current practice for the front two stages. Results of the CFD simulation at the aerodynamic design point are interrogated to identify areas requiring additional development. In spite of the significantly higher aerodynamic loadings, advanced CFD-based tools were able to effectively guide the design of a very efficient axial compressor under state-of-the-art aeromechanical constraints.

State of the art of sonic boom modeling

NASA Astrophysics Data System (ADS)

Plotkin, Kenneth J.

2002-01-01

Based on fundamental theory developed through the 1950s and 1960s, sonic boom modeling has evolved into practical tools. Over the past decade, there have been requirements for design tools for an advanced supersonic transport, and for tools for environmental assessment of various military and aerospace activities. This has resulted in a number of advances in the understanding of the physics of sonic booms, including shock wave rise times, propagation through turbulence, and blending sonic boom theory with modern computational fluid dynamics (CFD) aerodynamic design methods. This article reviews the early fundamental theory, recent advances in theory, and the application of these advances to practical models.

State of the art of sonic boom modeling.

PubMed

Plotkin, Kenneth J

2002-01-01

Based on fundamental theory developed through the 1950s and 1960s, sonic boom modeling has evolved into practical tools. Over the past decade, there have been requirements for design tools for an advanced supersonic transport, and for tools for environmental assessment of various military and aerospace activities. This has resulted in a number of advances in the understanding of the physics of sonic booms, including shock wave rise times, propagation through turbulence, and blending sonic boom theory with modern computational fluid dynamics (CFD) aerodynamic design methods. This article reviews the early fundamental theory, recent advances in theory, and the application of these advances to practical models.

NASA gear research and its probable effect on rotorcraft transmission design

NASA Technical Reports Server (NTRS)

Zaretsky, E. V.; Townsend, D. P.; Coy, J. J.

1979-01-01

The results of the NASA gear research is reviewed as well as those programs which are presently being undertaken. Research programs studying pitting fatigue, gear steels and processing, life prediction methods, gear design and dynamics, elastohydrodynamic lubrication, lubrication methods and gear noise are presented. The impact of advanced gear research technology on rotorcraft transmission design is discussed.

Voltage Drop Compensation Method for Active Matrix Organic Light Emitting Diode Displays

NASA Astrophysics Data System (ADS)

Choi, Sang-moo; Ryu, Do-hyung; Kim, Keum-nam; Choi, Jae-beom; Kim, Byung-hee; Berkeley, Brian

2011-03-01

In this paper, the conventional voltage drop compensation methods are reviewed and the novel design and driving scheme, the advanced power de-coupled (aPDC) driving method, is proposed to effectively compensate the voltage IR drop of active matrix light emitting diode (AMOLED) displays. The advanced PDC driving scheme can be applied to general AMOLED pixel circuits that have been developed with only minor modification or without requiring modification in pixel circuit. A 14-in. AMOLED panel with the aPDC driving scheme was fabricated. Long range uniformity (LRU) of the 14-in. AMOLED panel was improved from 43% without the aPDC driving scheme, to over 87% at the same brightness by using the scheme and the layout complexity of the panel with new design scheme is less than that of the panel with the conventional design scheme.

Study of structural design concepts for an arrow wing supersonic transport configuration, volume 1. Tasks 1 and 2

NASA Technical Reports Server (NTRS)

1976-01-01

A structural design study was made, based on a 1975 level of technology, to assess the relative merits of structural concepts and materials for an advanced supersonic transport cruising at Mach 2.7. Preliminary studies were made to insure compliance of the configuration with general design criteria, to integrate the propulsion system with the airframe, to select structural concepts and materials, and to define an efficient structural arrangement. An advanced computerized structural design system was used, in conjunction with a relatively large, complex finite element model, for detailed analysis and sizing of structural members to satisfy strength and flutter criteria. A baseline aircraft design was developed for assessment of current technology and for use in future studies of aerostructural trades, and application of advanced technology. Criteria, analysis methods, and results are presented.

Interactive program for analysis and design problems in advanced composites technology

NASA Technical Reports Server (NTRS)

Cruse, T. A.; Swedlow, J. L.

1971-01-01

During the past year an experimental program in the fracture of advanced fiber composites has been completed. The experimental program has given direction to additional experimental and theoretical work. A synthesis program for designing low weight multifastener joints in composites is proposed, based on extensive analytical background. A number of failed joints have been thoroughly analyzed to evaluate the failure hypothesis used in the synthesis procedure. Finally, a new solution is reported for isotropic and anisotropic laminates using the boundary-integral method. The solution method offers significant savings of computer core and time for important problems.

NASA GRC Fatigue Crack Initiation Life Prediction Models

NASA Technical Reports Server (NTRS)

Arya, Vinod K.; Halford, Gary R.

2002-01-01

Metal fatigue has plagued structural components for centuries, and it remains a critical durability issue in today's aerospace hardware. This is true despite vastly improved and advanced materials, increased mechanistic understanding, and development of accurate structural analysis and advanced fatigue life prediction tools. Each advance is quickly taken advantage of to produce safer, more reliable, more cost effective, and better performing products. In other words, as the envelope is expanded, components are then designed to operate just as close to the newly expanded envelope as they were to the initial one. The problem is perennial. The economic importance of addressing structural durability issues early in the design process is emphasized. Tradeoffs with performance, cost, and legislated restrictions are pointed out. Several aspects of structural durability of advanced systems, advanced materials and advanced fatigue life prediction methods are presented. Specific items include the basic elements of durability analysis, conventional designs, barriers to be overcome for advanced systems, high-temperature life prediction for both creep-fatigue and thermomechanical fatigue, mean stress effects, multiaxial stress-strain states, and cumulative fatigue damage accumulation assessment.

NASA GRC Fatigue Crack Initiation Life Prediction Models

NASA Astrophysics Data System (ADS)

Arya, Vinod K.; Halford, Gary R.

2002-10-01

Metal fatigue has plagued structural components for centuries, and it remains a critical durability issue in today's aerospace hardware. This is true despite vastly improved and advanced materials, increased mechanistic understanding, and development of accurate structural analysis and advanced fatigue life prediction tools. Each advance is quickly taken advantage of to produce safer, more reliable, more cost effective, and better performing products. In other words, as the envelope is expanded, components are then designed to operate just as close to the newly expanded envelope as they were to the initial one. The problem is perennial. The economic importance of addressing structural durability issues early in the design process is emphasized. Tradeoffs with performance, cost, and legislated restrictions are pointed out. Several aspects of structural durability of advanced systems, advanced materials and advanced fatigue life prediction methods are presented. Specific items include the basic elements of durability analysis, conventional designs, barriers to be overcome for advanced systems, high-temperature life prediction for both creep-fatigue and thermomechanical fatigue, mean stress effects, multiaxial stress-strain states, and cumulative fatigue damage accumulation assessment.

Engineering in complex systems.

PubMed

Bujara, Matthias; Panke, Sven

2010-10-01

The implementation of the engineering design cycle of measure, model, manipulate would drastically enhance the success rate of biotechnological designs. Recent progress for the three elements suggests that the scope of the traditional engineering paradigm in biotechnology is expanding. Substantial advances were made in dynamic in vivo analysis of metabolism, which is essential for the accurate prediction of metabolic pathway behavior. Novel methods that require variable degrees of system knowledge facilitate metabolic system manipulation. The combinatorial testing of pre-characterized parts is particularly promising, because it can profit from automation and limits the search space. Finally, conceptual advances in orthogonalizing cells should enhance the reliability of engineering designs in the future. Coupled to improved in silico models of metabolism, these advances should allow a more rational design of metabolic systems. Copyright © 2010 Elsevier Ltd. All rights reserved.

Preliminary design and analysis of an advanced rotorcraft transmission

NASA Technical Reports Server (NTRS)

Henry, Z. S.

1990-01-01

Future rotorcraft transmissions of the 1990s and beyond the year 2000 require the incorporation of key emerging material and component technologies using advanced and innovative design practices in order to meet the requirements for a reduced weight-to-power ratio, a decreased noise level, and a substantially increased reliability. The specific goals for future rotocraft transmissions when compared with current state-of-the-art transmissions are a 25 percent weight reduction, a 10-dB reduction in the transmitted noise level, and a system reliability of 5000 hours mean-time-between-removal for the transmission. This paper presents the results of the design studies conducted to meet the stated goals for an advanced rotorcraft transmission. These design studies include system configuration, planetary gear train selection, and reliability prediction methods.

Unstructured viscous grid generation by advancing-front method

NASA Technical Reports Server (NTRS)

Pirzadeh, Shahyar

1993-01-01

A new method of generating unstructured triangular/tetrahedral grids with high-aspect-ratio cells is proposed. The method is based on new grid-marching strategy referred to as 'advancing-layers' for construction of highly stretched cells in the boundary layer and the conventional advancing-front technique for generation of regular, equilateral cells in the inviscid-flow region. Unlike the existing semi-structured viscous grid generation techniques, the new procedure relies on a totally unstructured advancing-front grid strategy resulting in a substantially enhanced grid flexibility and efficiency. The method is conceptually simple but powerful, capable of producing high quality viscous grids for complex configurations with ease. A number of two-dimensional, triangular grids are presented to demonstrate the methodology. The basic elements of the method, however, have been primarily designed with three-dimensional problems in mind, making it extendible for tetrahedral, viscous grid generation.

Structure and Computation in Immunoreagent Design: From Diagnostics to Vaccines.

PubMed

Gourlay, Louise; Peri, Claudio; Bolognesi, Martino; Colombo, Giorgio

2017-12-01

Novel immunological tools for efficient diagnosis and treatment of emerging infections are urgently required. Advances in the diagnostic and vaccine development fields are continuously progressing, with reverse vaccinology and structural vaccinology (SV) methods for antigen identification and structure-based antigen (re)design playing increasingly relevant roles. SV, in particular, is predicted to be the front-runner in the future development of diagnostics and vaccines targeting challenging diseases such as AIDS and cancer. We review state-of-the-art methodologies for structure-based epitope identification and antigen design, with specific applicative examples. We highlight the implications of such methods for the engineering of biomolecules with improved immunological properties, potential diagnostic and/or therapeutic uses, and discuss the perspectives of structure-based rational design for the production of advanced immunoreagents. Copyright © 2017 Elsevier Ltd. All rights reserved.

Advanced Method of Boundary-Layer Control Based on Localized Plasma Generation

DTIC Science & Technology

2009-05-01

measurements, validation of experiments, wind-tunnel testing of the microwave / plasma generation system , preliminary assessment of energy required...and design of a microwave generator , electrodynamic and multivibrator systems for experiments in the IHM-NAU wind tunnel: MW generator and its high...equipped with the microwave - generation and protection systems to study advanced methods of flow control (Kiev) Fig. 2.1,a. The blade

ITER structural design criteria and their extension to advanced reactor blankets*1

NASA Astrophysics Data System (ADS)

Majumdar, S.; Kalinin, G.

2000-12-01

Applications of the recent ITER structural design criteria (ISDC) are illustrated by two components. First, the low-temperature-design rules are applied to copper alloys that are particularly prone to irradiation embrittlement at relatively low fluences at certain temperatures. Allowable stresses are derived and the impact of the embrittlement on allowable surface heat flux of a simple first-wall/limiter design is demonstrated. Next, the high-temperature-design rules of ISDC are applied to evaporation of lithium and vapor extraction (EVOLVE), a blanket design concept currently being investigated under the US Advanced Power Extraction (APEX) program. A single tungsten first-wall tube is considered for thermal and stress analyses by finite-element method.

Advanced superposition methods for high speed turbopump vibration analysis

NASA Technical Reports Server (NTRS)

Nielson, C. E.; Campany, A. D.

1981-01-01

The small, high pressure Mark 48 liquid hydrogen turbopump was analyzed and dynamically tested to determine the cause of high speed vibration at an operating speed of 92,400 rpm. This approaches the design point operating speed of 95,000 rpm. The initial dynamic analysis in the design stage and subsequent further analysis of the rotor only dynamics failed to predict the vibration characteristics found during testing. An advanced procedure for dynamics analysis was used in this investigation. The procedure involves developing accurate dynamic models of the rotor assembly and casing assembly by finite element analysis. The dynamically instrumented assemblies are independently rap tested to verify the analytical models. The verified models are then combined by modal superposition techniques to develop a completed turbopump model where dynamic characteristics are determined. The results of the dynamic testing and analysis obtained are presented and methods of moving the high speed vibration characteristics to speeds above the operating range are recommended. Recommendations for use of these advanced dynamic analysis procedures during initial design phases are given.

Study of flutter related computational procedures for minimum weight structural sizing of advanced aircraft

NASA Technical Reports Server (NTRS)

Oconnell, R. F.; Hassig, H. J.; Radovcich, N. A.

1976-01-01

Results of a study of the development of flutter modules applicable to automated structural design of advanced aircraft configurations, such as a supersonic transport, are presented. Automated structural design is restricted to automated sizing of the elements of a given structural model. It includes a flutter optimization procedure; i.e., a procedure for arriving at a structure with minimum mass for satisfying flutter constraints. Methods of solving the flutter equation and computing the generalized aerodynamic force coefficients in the repetitive analysis environment of a flutter optimization procedure are studied, and recommended approaches are presented. Five approaches to flutter optimization are explained in detail and compared. An approach to flutter optimization incorporating some of the methods discussed is presented. Problems related to flutter optimization in a realistic design environment are discussed and an integrated approach to the entire flutter task is presented. Recommendations for further investigations are made. Results of numerical evaluations, applying the five methods of flutter optimization to the same design task, are presented.

Cost and accuracy of advanced breeding trial designs in apple

PubMed Central

Harshman, Julia M; Evans, Kate M; Hardner, Craig M

2016-01-01

Trialing advanced candidates in tree fruit crops is expensive due to the long-term nature of the planting and labor-intensive evaluations required to make selection decisions. How closely the trait evaluations approximate the true trait value needs balancing with the cost of the program. Designs of field trials of advanced apple candidates in which reduced number of locations, the number of years and the number of harvests per year were modeled to investigate the effect on the cost and accuracy in an operational breeding program. The aim was to find designs that would allow evaluation of the most additional candidates while sacrificing the least accuracy. Critical percentage difference, response to selection, and correlated response were used to examine changes in accuracy of trait evaluations. For the quality traits evaluated, accuracy and response to selection were not substantially reduced for most trial designs. Risk management influences the decision to change trial design, and some designs had greater risk associated with them. Balancing cost and accuracy with risk yields valuable insight into advanced breeding trial design. The methods outlined in this analysis would be well suited to other horticultural crop breeding programs. PMID:27019717

An airline study of advanced technology requirements for advanced high speed commercial transport engines. 1: Engine design study assessment

NASA Technical Reports Server (NTRS)

Sallee, G. P.

1973-01-01

The advanced technology requirements for an advanced high speed commercial tranport engine are presented. The results of the phase 1 study effort cover the following areas: (1) statement of an airline's major objectives for future transport engines, (2) airline's method of evaluating engine proposals, (3) description of an optimum engine for a long range subsonic commercial transport including installation and critical design features, (4) discussion of engine performance problems and experience with performance degradation, (5) trends in engine and pod prices with increasing technology and objectives for the future, (6) discussion of the research objectives for composites, reversers, advanced components, engine control systems, and devices to reduce the impact of engine stall, and (7) discussion of the airline objectives for noise and pollution reduction.

Advances in visual representation of molecular potentials.

PubMed

Du, Qi-Shi; Huang, Ri-Bo; Chou, Kuo-Chen

2010-06-01

The recent advances in visual representations of molecular properties in 3D space are summarized, and their applications in molecular modeling study and rational drug design are introduced. The visual representation methods provide us with detailed insights into protein-ligand interactions, and hence can play a major role in elucidating the structure or reactivity of a biomolecular system. Three newly developed computation and visualization methods for studying the physical and chemical properties of molecules are introduced, including their electrostatic potential, lipophilicity potential and excess chemical potential. The newest application examples of visual representations in structure-based rational drug are presented. The 3D electrostatic potentials, calculated using the empirical method (EM-ESP), in which the classical Coulomb equation and traditional atomic partial changes are discarded, are highly consistent with the results by the higher level quantum chemical method. The 3D lipophilicity potentials, computed by the heuristic molecular lipophilicity potential method based on the principles of quantum mechanics and statistical mechanics, are more accurate and reliable than those by using the traditional empirical methods. The 3D excess chemical potentials, derived by the reference interaction site model-hypernetted chain theory, provide a new tool for computational chemistry and molecular modeling. For structure-based drug design, the visual representations of molecular properties will play a significant role in practical applications. It is anticipated that the new advances in computational chemistry will stimulate the development of molecular modeling methods, further enriching the visual representation techniques for rational drug design, as well as other relevant fields in life science.

Designing Needs Statements in a Systematic Iterative Way

ERIC Educational Resources Information Center

Verstegen, D. M. L.; Barnard, Y. F.; Pilot, A.

2009-01-01

Designing specifications for technically advanced instructional products, such as e-learning, simulations or simulators requires different kinds of expertise. The SLIM method proposes to involve all stakeholders from the beginning in a series of workshops under the guidance of experienced instructional designers. These instructional designers…

Structures and Materials Working Group report

NASA Technical Reports Server (NTRS)

Torczyner, Robert; Hanks, Brantley R.

1986-01-01

The appropriateness of the selection of four issues (advanced materials development, analysis/design methods, tests of large flexible structures, and structural concepts) was evaluated. A cross-check of the issues and their relationship to the technology drivers is presented. Although all of the issues addressed numerous drivers, the advanced materials development issue impacts six out of the seven drivers and is considered to be the most crucial. The advanced materials technology development and the advanced design/analysis methods development were determined to be enabling technologies with the testing issues and development of structural concepts considered to be of great importance, although not enabling technologies. In addition, and of more general interest and criticality, the need for a Government/Industry commitment which does not now exist, was established. This commitment would call for the establishment of the required infrastructure to facilitate the development of the capabilities highlighted through the availability of resources and testbed facilities, including a national testbed in space to be in place in ten years.

Feedstock powder processing research needs for additive manufacturing development

DOE PAGES

Anderson, Iver E.; White, Emma M. H.; Dehoff, Ryan

2018-02-01

Additive manufacturing (AM) promises to redesign traditional manufacturing by enabling the ultimate in agility for rapid component design changes in commercial products and for fabricating complex integrated parts. Here, by significantly increasing quality and yield of metallic alloy powders, the pace for design, development, and deployment of the most promising AM approaches can be greatly accelerated, resulting in rapid commercialization of these advanced manufacturing methods. By successful completion of a critical suite of processing research tasks that are intended to greatly enhance gas atomized powder quality and the precision and efficiency of powder production, researchers can help promote continued rapidmore » growth of AM. Finally, other powder-based or spray-based advanced manufacturing methods could also benefit from these research outcomes, promoting the next wave of sustainable manufacturing technologies for conventional and advanced materials.« less

Feedstock powder processing research needs for additive manufacturing development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anderson, Iver E.; White, Emma M. H.; Dehoff, Ryan

Additive manufacturing (AM) promises to redesign traditional manufacturing by enabling the ultimate in agility for rapid component design changes in commercial products and for fabricating complex integrated parts. Here, by significantly increasing quality and yield of metallic alloy powders, the pace for design, development, and deployment of the most promising AM approaches can be greatly accelerated, resulting in rapid commercialization of these advanced manufacturing methods. By successful completion of a critical suite of processing research tasks that are intended to greatly enhance gas atomized powder quality and the precision and efficiency of powder production, researchers can help promote continued rapidmore » growth of AM. Finally, other powder-based or spray-based advanced manufacturing methods could also benefit from these research outcomes, promoting the next wave of sustainable manufacturing technologies for conventional and advanced materials.« less

Optics of high-performance electron microscopes*

PubMed Central

Rose, H H

2008-01-01

During recent years, the theory of charged particle optics together with advances in fabrication tolerances and experimental techniques has lead to very significant advances in high-performance electron microscopes. Here, we will describe which theoretical tools, inventions and designs have driven this development. We cover the basic theory of higher-order electron optics and of image formation in electron microscopes. This leads to a description of different methods to correct aberrations by multipole fields and to a discussion of the most advanced design that take advantage of these techniques. The theory of electron mirrors is developed and it is shown how this can be used to correct aberrations and to design energy filters. Finally, different types of energy filters are described. PMID:27877933

An analytical study for the design of advanced rotor airfoils

NASA Technical Reports Server (NTRS)

Kemp, L. D.

1973-01-01

A theoretical study has been conducted to design and evaluate two airfoils for helicopter rotors. The best basic shape, designed with a transonic hodograph design method, was modified to meet subsonic criteria. One airfoil had an additional constraint for low pitching-moment at the transonic design point. Airfoil characteristics were predicted. Results of a comparative analysis of helicopter performance indicate that the new airfoils will produce reduced rotor power requirements compared to the NACA 0012. The hodograph design method, written in CDC Algol, is listed and described.

Recent progress in inverse methods in France

NASA Technical Reports Server (NTRS)

Bry, Pierre-Francois; Jacquotte, Olivier-Pierre; Lepape, Marie-Claire

1991-01-01

Given the current level of jet engine performance, improvement of the various turbomachinery components requires the use of advanced methods in aerodynamics, heat transfer, and aeromechanics. In particular, successful blade design can only be achieved via numerical design methods which make it possible to reach optimized solutions in a much shorter time than ever before. Two design methods which are currently being used throughout the French turbomachinery industry to obtain optimized blade geometries are presented. Examples are presented for compressor and turbine applications. The status of these methods as far as improvement and extension to new fields of applications is also reported.

Acoustic prediction methods for the NASA generalized advanced propeller analysis system (GAPAS)

NASA Technical Reports Server (NTRS)

Padula, S. L.; Block, P. J. W.

1984-01-01

Classical methods of propeller performance analysis are coupled with state-of-the-art Aircraft Noise Prediction Program (ANOPP:) techniques to yield a versatile design tool, the NASA Generalized Advanced Propeller Analysis System (GAPAS) for the novel quiet and efficient propellers. ANOPP is a collection of modular specialized programs. GAPAS as a whole addresses blade geometry and aerodynamics, rotor performance and loading, and subsonic propeller noise.

MSFC Advanced Concepts Office and the Iterative Launch Vehicle Concept Method

NASA Technical Reports Server (NTRS)

Creech, Dennis

2011-01-01

This slide presentation reviews the work of the Advanced Concepts Office (ACO) at Marshall Space Flight Center (MSFC) with particular emphasis on the method used to model launch vehicles using INTegrated ROcket Sizing (INTROS), a modeling system that assists in establishing the launch concept design, and stage sizing, and facilitates the integration of exterior analytic efforts, vehicle architecture studies, and technology and system trades and parameter sensitivities.

Assessing Students' Structured Programming Skills with Java: The "Blue, Berry, and Blueberry" Assignment

ERIC Educational Resources Information Center

Zhang, Xihui

2010-01-01

Java is an object-oriented programming language. From a software engineering perspective, object-oriented design and programming is used at the architectural design, and structured design and programming is used at the detailed design within methods. As such, structured programming skills are fundamental to more advanced object-oriented…

An efficient liner cooling scheme for advanced small gas turbine combustors

NASA Technical Reports Server (NTRS)

Paskin, Marc D.; Mongia, Hukam C.; Acosta, Waldo A.

1993-01-01

A joint Army/NASA program was conducted to design, fabricate, and test an advanced, small gas turbine, reverse-flow combustor utilizing a compliant metal/ceramic (CMC) wall cooling concept. The objectives of this effort were to develop a design method (basic design data base and analysis) for the CMC cooling technique and then demonstrate its application to an advanced cycle, small, reverse-flow combustor with 3000 F burner outlet temperature. The CMC concept offers significant improvements in wall cooling effectiveness resulting in a large reduction in cooling air requirements. Therefore, more air is available for control of burner outlet temperature pattern in addition to the benefits of improved efficiency, reduced emissions, and lower smoke levels. The program was divided into four tasks. Task 1 defined component materials and localized design of the composite wall structure in conjunction with development of basic design models for the analysis of flow and heat transfer through the wall. Task 2 included implementation of the selected materials and validated design models during combustor preliminary design. Detail design of the selected combustor concept and its refinement with 3D aerothermal analysis were completed in Task 3. Task 4 covered detail drawings, process development and fabrication, and a series of burner rig tests. The purpose of this paper is to provide details of the investigation into the fundamental flow and heat transfer characteristics of the CMC wall structure as well as implementation of the fundamental analysis method for full-scale combustor design.

Advanced designs for IPV nickel-hydrogen cells

NASA Technical Reports Server (NTRS)

Smithrick, J. J.; Manzo, M. A.; Gonzalez-Sanabria, O. D.

1984-01-01

Advanced designs for individual pressure vessel nickel-hydrogen cells have been concieved which should improve the cycle life at deep depths-of-discharge. Features of the designs which are new and not incorporated in either of the contemporary cells (Air Force/Hughes, Comsat) are: (1) use of alternate methods of oxygen recombination, (2) use of serrated edge separators to facilitate movement of gas within the cell while still maintaining required physical contact with the wall wick, and (3) use of an expandable stack to accommodate some of the nickel electrode expansion. The designs also consider electrolyte volume requirements over the life of the cells, and are fully compatible with the Air Force/Hughes design.

Design of solar thermal dryers for 24-hour food drying processes

USDA-ARS?s Scientific Manuscript database

Solar drying is a method that has been adopted for many years as a food preservation method. To this date, significant advancements have been made in this field with the adoption of a multitude of solar thermal dryer designs for single-layer and multi-layer drying of fruit and vegetables e.g. cabine...

Green design assessment of electromechanical products based on group weighted-AHP

NASA Astrophysics Data System (ADS)

Guo, Jinwei; Zhou, MengChu; Li, Zhiwu; Xie, Huiguang

2015-11-01

Manufacturing industry is the backbone of a country's economy while environmental pollution is a serious problem that human beings must face today. The green design of electromechanical products based on enterprise information systems is an important method to solve the environmental problem. The question on how to design green products must be answered by excellent designers via both advanced design methods and effective assessment methods of electromechanical products. Making an objective and precise assessment of green design is one of the problems that must be solved when green design is conducted. An assessment method of green design on electromechanical products based on Group Weighted-AHP (Analytic Hierarchy Process) is proposed in this paper, together with the characteristics of green products. The assessment steps of green design are also established. The results are illustrated via the assessment of a refrigerator design.

Experiences in integrating auto-translated state-chart designs for model checking

NASA Technical Reports Server (NTRS)

Pingree, P. J.; Benowitz, E. G.

2003-01-01

In the complex environment of JPL's flight missions with increasing dependency on advanced software designs, traditional software validation methods of simulation and testing are being stretched to adequately cover the needs of software development.

Advanced Energy Storage Devices: Basic Principles, Analytical Methods, and Rational Materials Design

PubMed Central

Liu, Jilei; Wang, Jin; Xu, Chaohe; Li, Chunzhong; Lin, Jianyi

2017-01-01

Abstract Tremendous efforts have been dedicated into the development of high‐performance energy storage devices with nanoscale design and hybrid approaches. The boundary between the electrochemical capacitors and batteries becomes less distinctive. The same material may display capacitive or battery‐like behavior depending on the electrode design and the charge storage guest ions. Therefore, the underlying mechanisms and the electrochemical processes occurring upon charge storage may be confusing for researchers who are new to the field as well as some of the chemists and material scientists already in the field. This review provides fundamentals of the similarities and differences between electrochemical capacitors and batteries from kinetic and material point of view. Basic techniques and analysis methods to distinguish the capacitive and battery‐like behavior are discussed. Furthermore, guidelines for material selection, the state‐of‐the‐art materials, and the electrode design rules to advanced electrode are proposed. PMID:29375964

Recent Patents and Designs on Hip Replacement Prostheses

PubMed Central

Derar, H; Shahinpoor, M

2015-01-01

Hip replacement surgery has gone through tremendous evolution since the first procedure in 1840. In the past five decades the advances that have been made in technology, advanced and smart materials innovations, surgical techniques, robotic surgery and methods of fixations and sterilization, facilitated hip implants that undergo multiple design revolutions seeking the least problematic implants and a longer survivorship. Hip surgery has become a solution for many in need of hip joint remedy and replacement across the globe. Nevertheless, there are still long-term problems that are essential to search and resolve to find the optimum implant. This paper reviews several recent patents on hip replacement surgery. The patents present various designs of prostheses, different materials as well as methods of fixation. Each of the patents presents a new design as a solution to different issues ranging from the longevity of the hip prostheses to discomfort and inconvenience experienced by patients in the long-term. PMID:25893020

Advanced Energy Storage Devices: Basic Principles, Analytical Methods, and Rational Materials Design.

PubMed

Liu, Jilei; Wang, Jin; Xu, Chaohe; Jiang, Hao; Li, Chunzhong; Zhang, Lili; Lin, Jianyi; Shen, Ze Xiang

2018-01-01

Tremendous efforts have been dedicated into the development of high-performance energy storage devices with nanoscale design and hybrid approaches. The boundary between the electrochemical capacitors and batteries becomes less distinctive. The same material may display capacitive or battery-like behavior depending on the electrode design and the charge storage guest ions. Therefore, the underlying mechanisms and the electrochemical processes occurring upon charge storage may be confusing for researchers who are new to the field as well as some of the chemists and material scientists already in the field. This review provides fundamentals of the similarities and differences between electrochemical capacitors and batteries from kinetic and material point of view. Basic techniques and analysis methods to distinguish the capacitive and battery-like behavior are discussed. Furthermore, guidelines for material selection, the state-of-the-art materials, and the electrode design rules to advanced electrode are proposed.

Advanced Rotorcraft Transmission (ART) program status

NASA Technical Reports Server (NTRS)

Bossler, Robert; Heath, Gregory

1991-01-01

Reported herein is work done on the Advanced Rotorcraft Transmission by McDonnell Douglas Helicopter Company under Army/NASA contract. The novel concept pursued includes the use of face gears for power transmission and a torque splitting arrangement. The design reduces the size and weight of the corner-turning hardware and the next reduction stage. New methods of analyzing face gears have increased confidence in their usefulness. Test gears have been designed and manufactured for power transmission testing on the NASA-Lewis spiral bevel test rig. Transmission design effort has included finite element modeling of the split torque paths to assure equal deflection under load. A finite element model of the Apache main transmission has been completed to substantiate noise prediction methods. A positive engagement overrunning clutch design is described. Test spur gears have been made by near-net-shape forging from five different materials. Three housing materials have been procured for evaluation testing.

Application of advanced high speed turboprop technology to future civil short-haul transport aircraft design

NASA Technical Reports Server (NTRS)

Conlon, J. A.; Bowles, J. V.

1978-01-01

With an overall goal of defining the needs and requirements for short-haul transport aircraft research and development, the objective of this paper is to determine the performance and noise impact of short-haul transport aircraft designed with an advanced turboprop propulsion system. This propulsion system features high-speed propellers that have more blades and reduced diameters. Aircraft are designed for short and medium field lengths; mission block fuel and direct operating costs (DOC) are used as performance measures. The propeller diameter was optimized to minimize DOC. Two methods are employed to estimate the weight of the acoustic treatment needed to reduce interior noise to an acceptable level. Results show decreasing gross weight, block fuel, DOC, engine size, and optimum propfan diameter with increasing field length. The choice of acoustic treatment method has a significant effect on the aircraft design.

Digital fabrication of textiles: an analysis of electrical networks in 3D knitted functional fabrics

NASA Astrophysics Data System (ADS)

Vallett, Richard; Knittel, Chelsea; Christe, Daniel; Castaneda, Nestor; Kara, Christina D.; Mazur, Krzysztof; Liu, Dani; Kontsos, Antonios; Kim, Youngmoo; Dion, Genevieve

2017-05-01

Digital fabrication methods are reshaping design and manufacturing processes through the adoption of pre-production visualization and analysis tools, which help minimize waste of materials and time. Despite the increasingly widespread use of digital fabrication techniques, comparatively few of these advances have benefited the design and fabrication of textiles. The development of functional fabrics such as knitted touch sensors, antennas, capacitors, and other electronic textiles could benefit from the same advances in electrical network modeling that revolutionized the design of integrated circuits. In this paper, the efficacy of using current state-of-the-art digital fabrication tools over the more common trialand- error methods currently used in textile design is demonstrated. Gaps are then identified in the current state-of-the-art tools that must be resolved to further develop and streamline the rapidly growing field of smart textiles and devices, bringing textile production into the realm of 21st century manufacturing.

Review of design optimization methods for turbomachinery aerodynamics

NASA Astrophysics Data System (ADS)

Li, Zhihui; Zheng, Xinqian

2017-08-01

In today's competitive environment, new turbomachinery designs need to be not only more efficient, quieter, and ;greener; but also need to be developed at on much shorter time scales and at lower costs. A number of advanced optimization strategies have been developed to achieve these requirements. This paper reviews recent progress in turbomachinery design optimization to solve real-world aerodynamic problems, especially for compressors and turbines. This review covers the following topics that are important for optimizing turbomachinery designs. (1) optimization methods, (2) stochastic optimization combined with blade parameterization methods and the design of experiment methods, (3) gradient-based optimization methods for compressors and turbines and (4) data mining techniques for Pareto Fronts. We also present our own insights regarding the current research trends and the future optimization of turbomachinery designs.

A knowledge-based design framework for airplane conceptual and preliminary design

NASA Astrophysics Data System (ADS)

Anemaat, Wilhelmus A. J.

The goal of work described herein is to develop the second generation of Advanced Aircraft Analysis (AAA) into an object-oriented structure which can be used in different environments. One such environment is the third generation of AAA with its own user interface, the other environment with the same AAA methods (i.e. the knowledge) is the AAA-AML program. AAA-AML automates the initial airplane design process using current AAA methods in combination with AMRaven methodologies for dependency tracking and knowledge management, using the TechnoSoft Adaptive Modeling Language (AML). This will lead to the following benefits: (1) Reduced design time: computer aided design methods can reduce design and development time and replace tedious hand calculations. (2) Better product through improved design: more alternative designs can be evaluated in the same time span, which can lead to improved quality. (3) Reduced design cost: due to less training and less calculation errors substantial savings in design time and related cost can be obtained. (4) Improved Efficiency: the design engineer can avoid technically correct but irrelevant calculations on incomplete or out of sync information, particularly if the process enables robust geometry earlier. Although numerous advancements in knowledge based design have been developed for detailed design, currently no such integrated knowledge based conceptual and preliminary airplane design system exists. The third generation AAA methods are tested over a ten year period on many different airplane designs. Using AAA methods will demonstrate significant time savings. The AAA-AML system will be exercised and tested using 27 existing airplanes ranging from single engine propeller, business jets, airliners, UAV's to fighters. Data for the varied sizing methods will be compared with AAA results, to validate these methods. One new design, a Light Sport Aircraft (LSA), will be developed as an exercise to use the tool for designing a new airplane. Using these tools will show an improvement in efficiency over using separate programs due to the automatic recalculation with any change of input data. The direct visual feedback of 3D geometry in the AAA-AML, will lead to quicker resolving of problems as opposed to conventional methods.

Design Method For Ultra-High Resolution Linear CCD Imagers

NASA Astrophysics Data System (ADS)

Sheu, Larry S.; Truong, Thanh; Yuzuki, Larry; Elhatem, Abdul; Kadekodi, Narayan

1984-11-01

This paper presents the design method to achieve ultra-high resolution linear imagers. This method utilizes advanced design rules and novel staggered bilinear photo sensor arrays with quadrilinear shift registers. Design constraint in the detector arrays and shift registers are analyzed. Imager architecture to achieve ultra-high resolution is presented. The characteristics of MTF, aliasing, speed, transfer efficiency and fine photolithography requirements associated with this architecture are also discussed. A CCD imager with advanced 1.5 um minimum feature size was fabricated. It is intended as a test vehicle for the next generation small sampling pitch ultra-high resolution CCD imager. Standard double-poly, two-phase shift registers were fabricated at an 8 um pitch using the advanced design rules. A special process step that blocked the source-drain implant from the shift register area was invented. This guaranteed excellent performance of the shift registers regardless of the small poly overlaps. A charge transfer efficiency of better than 0.99995 and maximum transfer speed of 8 MHz were achieved. The imager showed excellent performance. The dark current was less than 0.2 mV/ms, saturation 250 mV, adjacent photoresponse non-uniformity ± 4% and responsivity 0.7 V/ μJ/cm2 for the 8 μm x 6 μm photosensor size. The MTF was 0.6 at 62.5 cycles/mm. These results confirm the feasibility of the next generation ultra-high resolution CCD imagers.

Joint QTL linkage mapping for multiple-cross mating design sharing one common parent

USDA-ARS?s Scientific Manuscript database

Nested association mapping (NAM) is a novel genetic mating design that combines the advantages of linkage analysis and association mapping. This design provides opportunities to study the inheritance of complex traits, but also requires more advanced statistical methods. In this paper, we present th...

A Graphical Approach to Teaching Amplifier Design at the Undergraduate Level

ERIC Educational Resources Information Center

Assaad, R. S.; Silva-Martinez, J.

2009-01-01

Current methods of teaching basic amplifier design at the undergraduate level need further development to match today's technological advances. The general class approach to amplifier design is analytical and heavily based on mathematical manipulations. However, the students mathematical abilities are generally modest, creating a void in which…

The NASA/USRA ADP at the University of Central Florida

NASA Technical Reports Server (NTRS)

Anderson, L. A.; Armitage, P. K.

1992-01-01

An approach to learning engineering design is discussed with particular attention given to the impact of the NASA/Universities Space Research Association (USRA) Advanced Design Program (ADP) on that process. Attention is also given to a teaching method stressing science discipline and creativity and various selected space related designs.

Open Education: Promise and Problems. Fastback Series, No. 3.

ERIC Educational Resources Information Center

Perrone, Vito

The term "open education" is used to designate the curriculum and instruction methods associated with an open plan school -- one without interior walls. Such a program consists of more advanced children assisting those less advanced, independent study, children progressing at their own rate, extensive use of the outdoor environment,…

IECEC '84: Advanced energy systems - Their role in our future; Proceedings of the Nineteenth Intersociety Energy Conversion Engineering Conference, San Francisco, CA, August 19-24, 1984. Volumes 1, 2, 3, & 4

NASA Astrophysics Data System (ADS)

Among the topics discussed are: advanced energy conversion concepts, power sources for aircraft and spacecraft, alternate fuels for industrial and vehicular applications, biomass-derived fuels, electric vehicle design and development status, electrochemical energy conversion systems, electric power generation cycles, energy-efficient industrial processes, and energy policy and system analysis. Also discussed are advanced methods for energy storage and transport, fossil fuel conversion systems, geothermal energy system development and performance, novel and advanced heat engines, hydrogen fuel-based energy systems, MHD technology development status, nuclear energy systems, solar energy conversion methods, advanced heating and cooling systems, Stirling cycle device development, terrestrial photovoltaic systems, and thermoelectric and thermionic systems.

Modified surface testing method for large convex aspheric surfaces based on diffraction optics.

PubMed

Zhang, Haidong; Wang, Xiaokun; Xue, Donglin; Zhang, Xuejun

2017-12-01

Large convex aspheric optical elements have been widely applied in advanced optical systems, which have presented a challenging metrology problem. Conventional testing methods cannot satisfy the demand gradually with the change of definition of "large." A modified method is proposed in this paper, which utilizes a relatively small computer-generated hologram and an illumination lens with certain feasibility to measure the large convex aspherics. Two example systems are designed to demonstrate the applicability, and also, the sensitivity of this configuration is analyzed, which proves the accuracy of the configuration can be better than 6 nm with careful alignment and calibration of the illumination lens in advance. Design examples and analysis show that this configuration is applicable to measure the large convex aspheric surfaces.

A Foundational Approach to Designing Geoscience Ontologies

NASA Astrophysics Data System (ADS)

Brodaric, B.

2009-05-01

E-science systems are increasingly deploying ontologies to aid online geoscience research. Geoscience ontologies are typically constructed independently by isolated individuals or groups who tend to follow few design principles. This limits the usability of the ontologies due to conceptualizations that are vague, conflicting, or narrow. Advances in foundational ontologies and formal engineering approaches offer promising solutions, but these advanced techniques have had limited application in the geosciences. This paper develops a design approach for geoscience ontologies by extending aspects of the DOLCE foundational ontology and the OntoClean method. Geoscience examples will be presented to demonstrate the feasibility of the approach.

Experiment Design for Complex VTOL Aircraft with Distributed Propulsion and Tilt Wing

NASA Technical Reports Server (NTRS)

Murphy, Patrick C.; Landman, Drew

2015-01-01

Selected experimental results from a wind tunnel study of a subscale VTOL concept with distributed propulsion and tilt lifting surfaces are presented. The vehicle complexity and automated test facility were ideal for use with a randomized designed experiment. Design of Experiments and Response Surface Methods were invoked to produce run efficient, statistically rigorous regression models with minimized prediction error. Static tests were conducted at the NASA Langley 12-Foot Low-Speed Tunnel to model all six aerodynamic coefficients over a large flight envelope. This work supports investigations at NASA Langley in developing advanced configurations, simulations, and advanced control systems.

Research on inverse, hybrid and optimization problems in engineering sciences with emphasis on turbomachine aerodynamics: Review of Chinese advances

NASA Technical Reports Server (NTRS)

Liu, Gao-Lian

1991-01-01

Advances in inverse design and optimization theory in engineering fields in China are presented. Two original approaches, the image-space approach and the variational approach, are discussed in terms of turbomachine aerodynamic inverse design. Other areas of research in turbomachine aerodynamic inverse design include the improved mean-streamline (stream surface) method and optimization theory based on optimal control. Among the additional engineering fields discussed are the following: the inverse problem of heat conduction, free-surface flow, variational cogeneration of optimal grid and flow field, and optimal meshing theory of gears.

Michael F. Crowley | NREL

Science.gov Websites

architectures. Crowlely's group has designed and implemented new methods and algorithms specifically for biomass , Crowley developed highly parallel methods for simulations of bio-macromolecules. Affiliated Research advanced sampling methods, Crowley and his team determine free energies such as binding of substrates

Overview of Sensitivity Analysis and Shape Optimization for Complex Aerodynamic Configurations

NASA Technical Reports Server (NTRS)

Newman, Perry A.; Newman, James C., III; Barnwell, Richard W.; Taylor, Arthur C., III; Hou, Gene J.-W.

1998-01-01

This paper presents a brief overview of some of the more recent advances in steady aerodynamic shape-design sensitivity analysis and optimization, based on advanced computational fluid dynamics. The focus here is on those methods particularly well- suited to the study of geometrically complex configurations and their potentially complex associated flow physics. When nonlinear state equations are considered in the optimization process, difficulties are found in the application of sensitivity analysis. Some techniques for circumventing such difficulties are currently being explored and are included here. Attention is directed to methods that utilize automatic differentiation to obtain aerodynamic sensitivity derivatives for both complex configurations and complex flow physics. Various examples of shape-design sensitivity analysis for unstructured-grid computational fluid dynamics algorithms are demonstrated for different formulations of the sensitivity equations. Finally, the use of advanced, unstructured-grid computational fluid dynamics in multidisciplinary analyses and multidisciplinary sensitivity analyses within future optimization processes is recommended and encouraged.

Advanced Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Technical Exchange Meeting

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Curtis

2013-09-01

During FY13, the INL developed an advanced SMR PRA framework which has been described in the report Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Detailed Technical Framework Specification, INL/EXT-13-28974 (April 2013). In this framework, the various areas are considered: Probabilistic models to provide information specific to advanced SMRs Representation of specific SMR design issues such as having co-located modules and passive safety features Use of modern open-source and readily available analysis methods Internal and external events resulting in impacts to safety All-hazards considerations Methods to support the identification of design vulnerabilities Mechanistic and probabilistic data needs to support modelingmore » and tools In order to describe this framework more fully and obtain feedback on the proposed approaches, the INL hosted a technical exchange meeting during August 2013. This report describes the outcomes of that meeting.« less

Advancing our thinking in presence-only and used-available analysis.

PubMed

Warton, David; Aarts, Geert

2013-11-01

1. The problems of analysing used-available data and presence-only data are equivalent, and this paper uses this equivalence as a platform for exploring opportunities for advancing analysis methodology. 2. We suggest some potential methodological advances in used-available analysis, made possible via lessons learnt in the presence-only literature, for example, using modern methods to improve predictive performance. We also consider the converse - potential advances in presence-only analysis inspired by used-available methodology. 3. Notwithstanding these potential advances in methodology, perhaps a greater opportunity is in advancing our thinking about how to apply a given method to a particular data set. 4. It is shown by example that strikingly different results can be achieved for a single data set by applying a given method of analysis in different ways - hence having chosen a method of analysis, the next step of working out how to apply it is critical to performance. 5. We review some key issues to consider in deciding how to apply an analysis method: apply the method in a manner that reflects the study design; consider data properties; and use diagnostic tools to assess how reasonable a given analysis is for the data at hand. © 2013 The Authors. Journal of Animal Ecology © 2013 British Ecological Society.

Application of Taguchi methods to dual mixture ratio propulsion system optimization for SSTO vehicles

NASA Technical Reports Server (NTRS)

Stanley, Douglas O.; Unal, Resit; Joyner, C. R.

1992-01-01

The application of advanced technologies to future launch vehicle designs would allow the introduction of a rocket-powered, single-stage-to-orbit (SSTO) launch system early in the next century. For a selected SSTO concept, a dual mixture ratio, staged combustion cycle engine that employs a number of innovative technologies was selected as the baseline propulsion system. A series of parametric trade studies are presented to optimize both a dual mixture ratio engine and a single mixture ratio engine of similar design and technology level. The effect of varying lift-off thrust-to-weight ratio, engine mode transition Mach number, mixture ratios, area ratios, and chamber pressure values on overall vehicle weight is examined. The sensitivity of the advanced SSTO vehicle to variations in each of these parameters is presented, taking into account the interaction of each of the parameters with each other. This parametric optimization and sensitivity study employs a Taguchi design method. The Taguchi method is an efficient approach for determining near-optimum design parameters using orthogonal matrices from design of experiments (DOE) theory. Using orthogonal matrices significantly reduces the number of experimental configurations to be studied. The effectiveness and limitations of the Taguchi method for propulsion/vehicle optimization studies as compared to traditional single-variable parametric trade studies is also discussed.

Fabrication and evaluation of advanced titanium structural panels for supersonic cruise aircraft

NASA Technical Reports Server (NTRS)

Payne, L.

1977-01-01

Flightworthy primary structural panels were designed, fabricated, and tested to investigate two advanced fabrication methods for titanium alloys. Skin-stringer panels fabricated using the weldbraze process, and honeycomb-core sandwich panels fabricated using a diffusion bonding process, were designed to replace an existing integrally stiffened shear panel on the upper wing surface of the NASA YF-12 research aircraft. The investigation included ground testing and Mach 3 flight testing of full-scale panels, and laboratory testing of representative structural element specimens. Test results obtained on full-scale panels and structural element specimens indicate that both of the fabrication methods investigated are suitable for primary structural applications on future civil and military supersonic cruise aircraft.

Applications of flight control system methods to an advanced combat rotorcraft

NASA Technical Reports Server (NTRS)

Tischler, Mark B.; Fletcher, Jay W.; Morris, Patrick M.; Tucker, George T.

1989-01-01

Advanced flight control system design, analysis, and testing methodologies developed at the Ames Research Center are applied in an analytical and flight test evaluation of the Advanced Digital Optical Control System (ADOCS) demonstrator. The primary objectives are to describe the knowledge gained about the implications of digital flight control system design for rotorcraft, and to illustrate the analysis of the resulting handling-qualities in the context of the proposed new handling-qualities specification for rotorcraft. Topics covered in-depth are digital flight control design and analysis methods, flight testing techniques, ADOCS handling-qualities evaluation results, and correlation of flight test results with analytical models and the proposed handling-qualities specification. The evaluation of the ADOCS demonstrator indicates desirable response characteristics based on equivalent damping and frequency, but undersirably large effective time-delays (exceeding 240 m sec in all axes). Piloted handling-qualities are found to be desirable or adequate for all low, medium, and high pilot gain tasks; but handling-qualities are inadequate for ultra-high gain tasks such as slope and running landings.

Material Testing and Initial Pavement Design Modeling: Minnesota Road Research Project

DOT National Transportation Integrated Search

1996-09-01

Between January 1990 and December 1994, a study verified and applied a Corps of Engineers-developed mechanistic design and evaluation method for pavements in seasonal frost areas as part of a Construction Productivity Advancement Research (CPAR) proj...

Initial performance of advanced designs for IPV nickel-hydrogen cells

NASA Technical Reports Server (NTRS)

Smithrick, John J.

1986-01-01

Advanced designs for individual pressure vessel nickel-hydrogen cells have been conceived which should improve the cycle life at deep depths-of-discharge and improve thermal management. Features of the designs which are new and not incorporated in either of the contemporary cells (Air Force/Hughes, Comsat) are: (1) use of alternate methods of oxygen recombination, (2) use of serrated edge separators to facilitate movement of gas within the cell while still maintaining required physical contact with the wall wick, and (3) use of an expandable stack to accommodate some of the nickel electrode expansion. The designs also consider electrolyte volume requirements over the life of the cells, and are fully compatible with the Air Force/Hughes design.

Initial performance of advanced designs for IPV nickel-hydrogen cells

NASA Technical Reports Server (NTRS)

Smithrick, J. J.

1985-01-01

Advanced designs for individual pressure vessel nickel hydrogen cells were conceived which should improve the life cycle at deep depths of discharge and improve thermal management. Features of the designs which are new and not incorporated in either of the contemporary cells (Air Force/Hughes, Comsat) are: (1) the use of alternate methods of oxygen recombination, (2) use of serrated edge separators to facilitate movement of gas within the cell while still maintaining required physical contact with the wall wick, and (3) use of an expandable stack to accommodate some of the nickel electrode expansion. The designs also consider electrolyte volume requirements over the life of the cells, and are fully compatible with the Air Force/Hughes design.

Using case study within a sequential explanatory design to evaluate the impact of specialist and advanced practice roles on clinical outcomes: the SCAPE study.

PubMed

Lalor, Joan G; Casey, Dympna; Elliott, Naomi; Coyne, Imelda; Comiskey, Catherine; Higgins, Agnes; Murphy, Kathy; Devane, Declan; Begley, Cecily

2013-04-08

The role of the clinical nurse/midwife specialist and advanced nurse/midwife practitioner is complex not least because of the diversity in how the roles are operationalised across health settings and within multidisciplinary teams. This aim of this paper is to use The SCAPE Study: Specialist Clinical and Advanced Practitioner Evaluation in Ireland to illustrate how case study was used to strengthen a Sequential Explanatory Design. In Phase 1, clinicians identified indicators of specialist and advanced practice which were then used to guide the instrumental case study design which formed the second phase of the larger study. Phase 2 used matched case studies to evaluate the effectiveness of specialist and advanced practitioners on clinical outcomes for service users. Data were collected through observation, documentary analysis, and interviews. Observations were made of 23 Clinical Specialists or Advanced Practitioners, and 23 matched clinicians in similar matched non-postholding sites, while they delivered care. Forty-one service users, 41 clinicians, and 23 Directors of Nursing or Midwifery were interviewed, and 279 service users completed a survey based on the components of CS and AP practice identified in Phase 1. A coding framework, and the generation of cross tabulation matrices in NVivo, was used to make explicit how the outcome measures were confirmed and validated from multiple sources. This strengthened the potential to examine single cases that seemed 'different', and allowed for cases to be redefined. Phase 3 involved interviews with policy-makers to set the findings in context. Case study is a powerful research strategy to use within sequential explanatory mixed method designs, and adds completeness to the exploration of complex issues in clinical practice. The design is flexible, allowing the use of multiple data collection methods from both qualitative and quantitative paradigms. Multiple approaches to data collection are needed to evaluate the impact of complex roles and interventions in health care outcomes and service delivery. Case study design is an appropriate methodology to use when study outcomes relate to clinical practice.

Mask manufacturing of advanced technology designs using multi-beam lithography (part 2)

NASA Astrophysics Data System (ADS)

Green, Michael; Ham, Young; Dillon, Brian; Kasprowicz, Bryan; Hur, Ik Boum; Park, Joong Hee; Choi, Yohan; McMurran, Jeff; Kamberian, Henry; Chalom, Daniel; Klikovits, Jan; Jurkovic, Michal; Hudek, Peter

2016-09-01

As optical lithography is extended into 10nm and below nodes, advanced designs are becoming a key challenge for mask manufacturers. Techniques including advanced optical proximity correction (OPC) and Inverse Lithography Technology (ILT) result in structures that pose a range of issues across the mask manufacturing process. Among the new challenges are continued shrinking sub-resolution assist features (SRAFs), curvilinear SRAFs, and other complex mask geometries that are counter-intuitive relative to the desired wafer pattern. Considerable capability improvements over current mask making methods are necessary to meet the new requirements particularly regarding minimum feature resolution and pattern fidelity. Advanced processes using the IMS Multi-beam Mask Writer (MBMW) are feasible solutions to these coming challenges. In this paper, Part 2 of our study, we further characterize an MBMW process for 10nm and below logic node mask manufacturing including advanced pattern analysis and write time demonstration.

Lifting off the Ground to Return Anew: Mediated Praxis, Transformative Learning, and Social Design Experiments

ERIC Educational Resources Information Center

Gutierrez, Kris D.; Vossoughi, Shirin

2010-01-01

This article examines a praxis model of teacher education and advances a new method for engaging novice teachers in reflective practice and robust teacher learning. Social design experiments--cultural historical formations designed to promote transformative learning for adults and children--are organized around expansive notions of learning and…

Developments in Cylindrical Shell Stability Analysis

NASA Technical Reports Server (NTRS)

Knight, Norman F., Jr.; Starnes, James H., Jr.

1998-01-01

Today high-performance computing systems and new analytical and numerical techniques enable engineers to explore the use of advanced materials for shell design. This paper reviews some of the historical developments of shell buckling analysis and design. The paper concludes by identifying key research directions for reliable and robust methods development in shell stability analysis and design.

Efficient species-level monitoring at the landscape scale

Treesearch

Barry R. Noon; Larissa L. Bailey; Thomas D. Sisk; Kevin S. McKelvey

2012-01-01

Monitoring the population trends of multiple animal species at a landscape scale is prohibitively expensive. However, advances in survey design, statistical methods, and the ability to estimate species presence on the basis of detection­nondetection data have greatly increased the feasibility of species-level monitoring. For example, recent advances in monitoring make...

Completion of Advance Directives: Do Social Work Preadmission Interviews Make a Difference?

ERIC Educational Resources Information Center

Johnson, Yvonne M.; Stadel, Vivian L.

2007-01-01

Objectives: This study tests the efficacy of a preadmission, educational interview on advance directives, in this case, health care proxies (HCPs) offered to elective, orthopedic patients. Method: Using a quasi-experimental design, participants (n = 54) are assigned to either treatment group (who received the educational interview, conducted by a…

Strategic Leadership: A Model for Promoting, Sustaining, and Advancing Institutional Significance

ERIC Educational Resources Information Center

Scott, Kenneth E.; Johnson, Mimi

2011-01-01

This article presents the methods, materials, and manpower required to create a strategic leadership program for promoting, sustaining, and advancing institutional significance. The functionality of the program is based on the Original Case Study Design (OCSD) methodology, in which participants are given actual college issues to investigate from a…

Experiences of Advanced High School Students in Synchronous Online Recitations

ERIC Educational Resources Information Center

Mayer, Greg; Lingle, Jeremy; Usselman, Marion

2017-01-01

The question of how to best design an online course that promotes student-centred learning is an area of ongoing research. This mixed-methods study focused on a section of advanced high school students, in college-level mathematics courses, that used a synchronous online environment mediated over web-conferencing software, and whether the…

Biotechnology Apprenticeship for Secondary-Level Students: Teaching Advanced Cell Culture Techniques for Research

ERIC Educational Resources Information Center

Lewis, Jennifer R.; Kotur, Mark S.; Butt, Omar; Kulcarni, Sumant; Riley, Alyssa A.; Ferrell, Nick; Sullivan, Kathryn D.; Ferrari, Mauro

2002-01-01

The purpose of this article is to discuss "small-group apprenticeships (SGAs)" as a method to instruct cell culture techniques to high school participants. The study aimed to teach cell culture practices and to introduce advanced imaging techniques to solve various biomedical engineering problems. Participants designed and completed experiments…

A Qualitative Analysis of an Advanced Practice Nurse-Directed Transitional Care Model Intervention

ERIC Educational Resources Information Center

Bradway, Christine; Trotta, Rebecca; Bixby, M. Brian; McPartland, Ellen; Wollman, M. Catherine; Kapustka, Heidi; McCauley, Kathleen; Naylor, Mary D.

2012-01-01

Purpose: The purpose of this study was to describe barriers and facilitators to implementing a transitional care intervention for cognitively impaired older adults and their caregivers lead by advanced practice nurses (APNs). Design and Methods: APNs implemented an evidence-based protocol to optimize transitions from hospital to home. An…

Fundamentals of Digital Engineering: Designing for Reliability

NASA Technical Reports Server (NTRS)

Katz, R.; Day, John H. (Technical Monitor)

2001-01-01

The concept of designing for reliability will be introduced along with a brief overview of reliability, redundancy and traditional methods of fault tolerance is presented, as applied to current logic devices. The fundamentals of advanced circuit design and analysis techniques will be the primary focus. The introduction will cover the definitions of key device parameters and how analysis is used to prove circuit correctness. Basic design techniques such as synchronous vs asynchronous design, metastable state resolution time/arbiter design, and finite state machine structure/implementation will be reviewed. Advanced topics will be explored such as skew-tolerant circuit design, the use of triple-modular redundancy and circuit hazards, device transients and preventative circuit design, lock-up states in finite state machines generated by logic synthesizers, device transient characteristics, radiation mitigation techniques. worst-case analysis, the use of timing analyzer and simulators, and others. Case studies and lessons learned from spaceflight designs will be given as examples

Advanced optical manufacturing digital integrated system

NASA Astrophysics Data System (ADS)

Tao, Yizheng; Li, Xinglan; Li, Wei; Tang, Dingyong

2012-10-01

It is necessarily to adapt development of advanced optical manufacturing technology with modern science technology development. To solved these problems which low of ration, ratio of finished product, repetition, consistent in big size and high precision in advanced optical component manufacturing. Applied business driven and method of Rational Unified Process, this paper has researched advanced optical manufacturing process flow, requirement of Advanced Optical Manufacturing integrated System, and put forward architecture and key technology of it. Designed Optical component core and Manufacturing process driven of Advanced Optical Manufacturing Digital Integrated System. the result displayed effective well, realized dynamic planning Manufacturing process, information integration improved ratio of production manufactory.

Contribution of developing advanced engineering methods in interdisciplinary studying the piston rings from 1.6 spark ignited Ford engine at Technical University of Cluj-Napoca

NASA Astrophysics Data System (ADS)

-Aurel Cherecheş, Ioan; -Ioana Borzan, Adela; -Laurean Băldean, Doru

2017-10-01

Study of construction and wearing process in the case of piston-rings and other significant components from internal combustion engines leads at any time to creative and useful optimizing ideas, both in designing and manufacturing phases. Main objective of the present paper is to realize an interdisciplinary research using advanced methods in piston-rings evaluation of a common vehicle on the streets which is Ford Focus FYDD. Specific objectives are a theoretical study of the idea for advanced analysis method in piston-rings evaluation and an applied research developed in at Technical University from Cluj-Napoca with the motor vehicle caught in the repairing process.

Computational thermo-fluid dynamics contributions to advanced gas turbine engine design

NASA Technical Reports Server (NTRS)

Graham, R. W.; Adamczyk, J. J.; Rohlik, H. E.

1984-01-01

The design practices for the gas turbine are traced throughout history with particular emphasis on the calculational or analytical methods. Three principal components of the gas turbine engine will be considered: namely, the compressor, the combustor and the turbine.

An advanced probabilistic structural analysis method for implicit performance functions

NASA Technical Reports Server (NTRS)

Wu, Y.-T.; Millwater, H. R.; Cruse, T. A.

1989-01-01

In probabilistic structural analysis, the performance or response functions usually are implicitly defined and must be solved by numerical analysis methods such as finite element methods. In such cases, the most commonly used probabilistic analysis tool is the mean-based, second-moment method which provides only the first two statistical moments. This paper presents a generalized advanced mean value (AMV) method which is capable of establishing the distributions to provide additional information for reliability design. The method requires slightly more computations than the second-moment method but is highly efficient relative to the other alternative methods. In particular, the examples show that the AMV method can be used to solve problems involving non-monotonic functions that result in truncated distributions.

Impact of Advanced Propeller Technology on Aircraft/Mission Characteristics of Several General Aviation Aircraft

NASA Technical Reports Server (NTRS)

Keiter, I. D.

1982-01-01

Studies of several General Aviation aircraft indicated that the application of advanced technologies to General Aviation propellers can reduce fuel consumption in future aircraft by a significant amount. Propeller blade weight reductions achieved through the use of composites, propeller efficiency and noise improvements achieved through the use of advanced concepts and improved propeller analytical design methods result in aircraft with lower operating cost, acquisition cost and gross weight.

Conformational diversity and computational enzyme design

PubMed Central

Lassila, Jonathan K.

2010-01-01

The application of computational protein design methods to the design of enzyme active sites offers potential routes to new catalysts and new reaction specificities. Computational design methods have typically treated the protein backbone as a rigid structure for the sake of computational tractability. However, this fixed-backbone approximation introduces its own special challenges for enzyme design and it contrasts with an emerging picture of natural enzymes as dynamic ensembles with multiple conformations and motions throughout a reaction cycle. This review considers the impact of conformational variation and dynamics on computational enzyme design and it highlights new approaches to addressing protein conformational diversity in enzyme design including recent advances in multistate design, backbone flexibility, and computational library design. PMID:20829099

Digital Phase-Locked Loop With Phase And Frequency Feedback

NASA Technical Reports Server (NTRS)

Thomas, J. Brooks

1991-01-01

Advanced design for digital phase-lock loop (DPLL) allows loop gains higher than those used in other designs. Divided into two major components: counterrotation processor and tracking processor. Notable features include use of both phase and rate-of-change-of-phase feedback instead of frequency feedback alone, normalized sine phase extractor, improved method for extracting measured phase, and improved method for "compressing" output rate.

Integration of mask and silicon metrology in DFM

NASA Astrophysics Data System (ADS)

Matsuoka, Ryoichi; Mito, Hiroaki; Sugiyama, Akiyuki; Toyoda, Yasutaka

2009-03-01

We have developed a highly integrated method of mask and silicon metrology. The method adopts a metrology management system based on DBM (Design Based Metrology). This is the high accurate contouring created by an edge detection algorithm used in mask CD-SEM and silicon CD-SEM. We have inspected the high accuracy, stability and reproducibility in the experiments of integration. The accuracy is comparable with that of the mask and silicon CD-SEM metrology. In this report, we introduce the experimental results and the application. As shrinkage of design rule for semiconductor device advances, OPC (Optical Proximity Correction) goes aggressively dense in RET (Resolution Enhancement Technology). However, from the view point of DFM (Design for Manufacturability), the cost of data process for advanced MDP (Mask Data Preparation) and mask producing is a problem. Such trade-off between RET and mask producing is a big issue in semiconductor market especially in mask business. Seeing silicon device production process, information sharing is not completely organized between design section and production section. Design data created with OPC and MDP should be linked to process control on production. But design data and process control data are optimized independently. Thus, we provided a solution of DFM: advanced integration of mask metrology and silicon metrology. The system we propose here is composed of followings. 1) Design based recipe creation: Specify patterns on the design data for metrology. This step is fully automated since they are interfaced with hot spot coordinate information detected by various verification methods. 2) Design based image acquisition: Acquire the images of mask and silicon automatically by a recipe based on the pattern design of CD-SEM.It is a robust automated step because a wide range of design data is used for the image acquisition. 3) Contour profiling and GDS data generation: An image profiling process is applied to the acquired image based on the profiling method of the field proven CD metrology algorithm. The detected edges are then converted to GDSII format, which is a standard format for a design data, and utilized for various DFM systems such as simulation. Namely, by integrating pattern shapes of mask and silicon formed during a manufacturing process into GDSII format, it makes it possible to bridge highly accurate pattern profile information over to the design field of various EDA systems. These are fully integrated into design data and automated. Bi-directional cross probing between mask data and process control data is allowed by linking them. This method is a solution for total optimization that covers Design, MDP, mask production and silicon device producing. This method therefore is regarded as a strategic DFM approach in the semiconductor metrology.

Toward a Psychological Science of Advanced Technology Design for Older Adults

PubMed Central

Fisk, Arthur D.

2010-01-01

Objectives. Technology represents advances in knowledge that change the way humans perform tasks. Ideally, technology will make the task easier, more efficient, safer, or perhaps more pleasurable. Unfortunately, new technologies can sometimes make a task more difficult, slower, dangerous, or perhaps more frustrating. Older adults interact with a variety of technologies in the course of their daily activities and thus products should be designed to be used by people of varying ages. Methods. In this article, we provide an overview of what psychology has to offer to the design of technology—from understanding what people need, to identifying their preferences for design characteristics, and to defining their capabilities and limitations that will influence technology interactions. Results. We identify how research in the field of psychology and aging has advanced understanding of technology interactions and how research on technology interactions can inform theories of aging. Discussion. Design for aging involves understanding the unique capabilities and limitations of older adults; identifying their needs, preferences, and desires for technology in their lives; and involving them in the design process. PMID:20833690

Application of Piloted Simulation to High-Angle-of-Attack Flight-Dynamics Research for Fighter Aircraft

NASA Technical Reports Server (NTRS)

Ogburn, Marilyn E.; Foster, John V.; Hoffler, Keith D.

2005-01-01

This paper reviews the use of piloted simulation at Langley Research Center as part of the NASA High-Angle-of-Attack Technology Program (HATP), which was created to provide concepts and methods for the design of advanced fighter aircraft. A major research activity within this program is the development of the design processes required to take advantage of the benefits of advanced control concepts for high-angle-of-attack agility. Fundamental methodologies associated with the effective use of piloted simulation for this research are described, particularly those relating to the test techniques, validation of the test results, and design guideline/criteria development.

Process optimization using combinatorial design principles: parallel synthesis and design of experiment methods.

PubMed

Gooding, Owen W

2004-06-01

The use of parallel synthesis techniques with statistical design of experiment (DoE) methods is a powerful combination for the optimization of chemical processes. Advances in parallel synthesis equipment and easy to use software for statistical DoE have fueled a growing acceptance of these techniques in the pharmaceutical industry. As drug candidate structures become more complex at the same time that development timelines are compressed, these enabling technologies promise to become more important in the future.

Stage acoustics for musicians: A multidimensional approach using 3D ambisonic technology

NASA Astrophysics Data System (ADS)

Guthrie, Anne

In this research, a method was outlined and tested for the use of 3D Ambisonic technology to inform stage acoustics research and design. Stage acoustics for musicians as a field has yet to benefit from recent advancements in auralization and spatial acoustic analysis. This research attempts to address common issues in stage acoustics: subjective requirements for performers in relation to feelings of support, quality of sound, and ease of ensemble playing in relation to measurable, objective characteristics that can be used to design better stage enclosures. While these issues have been addressed in previous work, this research attempts to use technological advancements to improve the resolution and realism of the testing and analysis procedures. Advancements include measurement of spatial impulse responses using a spherical microphone array, higher-order ambisonic encoding and playback for real-time performer auralization, high-resolution spatial beamforming for analysis of onstage impulse responses, and multidimensional scaling procedures to determine subjective musician preferences. The methodology for implementing these technologies into stage acoustics research is outlined in this document and initial observations regarding implications for stage enclosure design are proposed. This research provides a robust method for measuring and analyzing performer experiences on multiple stages without the costly and time-intensive process of physically surveying orchestras on different stages, with increased repeatability while maintaining a high level of immersive realism and spatial resolution. Along with implications for physical design, this method provides possibilities for virtual teaching and rehearsal, parametric modeling and co-located performance.

Procedure for analysis and design of weaving sections : volume 2, users guide.

DOT National Transportation Integrated Search

1983-12-01

This research was performed to complete and advance the status of recently developed procedures for analysis and design of weaving sections (known as the Leisch method and-initially published in the 1979 issue of ITE Journal). The objective was to en...

ARC Collaborative Research Seminar Series

Science.gov Websites

been used to formulate design rules for hydration-based TES systems. Don Siegel is an Associate structural-acoustics, design of complex systems, and blast event simulations. Technology that he developed interests includes advanced fatigue and fracture assessment methodologies, computational methods for

Advances in electrometer vacuum tube design

NASA Technical Reports Server (NTRS)

1970-01-01

Single-ended, miniature-cathode tube with a relatively low grid current level is constructed. Adequate cathode temperature at relatively low heater power drain is provided by designing the supporting spacers to provide a square cathode hole. Method of assembling the mount and bonding the elements is discussed.

Computational Aeroelastic Modeling of Airframes and TurboMachinery: Progress and Challenges

NASA Technical Reports Server (NTRS)

Bartels, R. E.; Sayma, A. I.

2006-01-01

Computational analyses such as computational fluid dynamics and computational structural dynamics have made major advances toward maturity as engineering tools. Computational aeroelasticity is the integration of these disciplines. As computational aeroelasticity matures it too finds an increasing role in the design and analysis of aerospace vehicles. This paper presents a survey of the current state of computational aeroelasticity with a discussion of recent research, success and continuing challenges in its progressive integration into multidisciplinary aerospace design. This paper approaches computational aeroelasticity from the perspective of the two main areas of application: airframe and turbomachinery design. An overview will be presented of the different prediction methods used for each field of application. Differing levels of nonlinear modeling will be discussed with insight into accuracy versus complexity and computational requirements. Subjects will include current advanced methods (linear and nonlinear), nonlinear flow models, use of order reduction techniques and future trends in incorporating structural nonlinearity. Examples in which computational aeroelasticity is currently being integrated into the design of airframes and turbomachinery will be presented.

Propeller flow visualization techniques

NASA Technical Reports Server (NTRS)

Stefko, G. L.; Paulovich, F. J.; Greissing, J. P.; Walker, E. D.

1982-01-01

Propeller flow visualization techniques were tested. The actual operating blade shape as it determines the actual propeller performance and noise was established. The ability to photographically determine the advanced propeller blade tip deflections, local flow field conditions, and gain insight into aeroelastic instability is demonstrated. The analytical prediction methods which are being developed can be compared with experimental data. These comparisons contribute to the verification of these improved methods and give improved capability for designing future advanced propellers with enhanced performance and noise characteristics.

NASA Marshall Space Flight Center Controls Systems Design and Analysis Branch

NASA Technical Reports Server (NTRS)

Gilligan, Eric

2014-01-01

Marshall Space Flight Center maintains a critical national capability in the analysis of launch vehicle flight dynamics and flight certification of GN&C algorithms. MSFC analysts are domain experts in the areas of flexible-body dynamics and control-structure interaction, thrust vector control, sloshing propellant dynamics, and advanced statistical methods. Marshall's modeling and simulation expertise has supported manned spaceflight for over 50 years. Marshall's unparalleled capability in launch vehicle guidance, navigation, and control technology stems from its rich heritage in developing, integrating, and testing launch vehicle GN&C systems dating to the early Mercury-Redstone and Saturn vehicles. The Marshall team is continuously developing novel methods for design, including advanced techniques for large-scale optimization and analysis.

The impact of materials technology and operational constraints on the economics of cruise speed selection

NASA Technical Reports Server (NTRS)

Clauss, J. S., Jr.; Bruckman, F. A.; Horning, D. L.; Johnston, R. H.; Werner, J. V.

1981-01-01

Six material concepts at Mach 2.0 and three material concepts at Mach 2.55 were proposed. The resulting evaluations, based on projected development, production, and operating costs, indicate that aircraft designs with advanced composites as the primary material ingredient have the lowest fare premiums at both Mach 2.0 and 2.55. Designs having advanced metallics as the primary material ingredient are not economical. Advanced titanium, employing advanced manufacturing methods such as SFF/DB, requires a fare premium of about 30 percent at both Mach 2.0 and 2.55. Advanced aluminum, usable only at the lower Mach number, requires a fare premium of 20 percent. Cruise speeds in the Mach 2.0-2.3 regime are preferred because of the better economics and because of the availability of two material concepts to reduce program risk - advanced composites and advanced aluminums. This cruise speed regime also avoids the increase in risk associated with the more complex inlets and airframe systems and higher temperature composite matrices required at the higher Mach numbers typified by Mach 2.55.

Design of Optical Systems with Extended Depth of Field: An Educational Approach to Wavefront Coding Techniques

ERIC Educational Resources Information Center

Ferran, C.; Bosch, S.; Carnicer, A.

2012-01-01

A practical activity designed to introduce wavefront coding techniques as a method to extend the depth of field in optical systems is presented. The activity is suitable for advanced undergraduate students since it combines different topics in optical engineering such as optical system design, aberration theory, Fourier optics, and digital image…

An objective method for a video quality evaluation in a 3DTV service

NASA Astrophysics Data System (ADS)

Wilczewski, Grzegorz

2015-09-01

The following article describes proposed objective method for a 3DTV video quality evaluation, a Compressed Average Image Intensity (CAII) method. Identification of the 3DTV service's content chain nodes enables to design a versatile, objective video quality metric. It is based on an advanced approach to the stereoscopic videostream analysis. Insights towards designed metric mechanisms, as well as the evaluation of performance of the designed video quality metric, in the face of the simulated environmental conditions are herein discussed. As a result, created CAII metric might be effectively used in a variety of service quality assessment applications.

Standardization Efforts for Mechanical Testing and Design of Advanced Ceramic Materials and Components

NASA Technical Reports Server (NTRS)

Salem, Jonathan A.; Jenkins, Michael G.

2003-01-01

Advanced aerospace systems occasionally require the use of very brittle materials such as sapphire and ultra-high temperature ceramics. Although great progress has been made in the development of methods and standards for machining, testing and design of component from these materials, additional development and dissemination of standard practices is needed. ASTM Committee C28 on Advanced Ceramics and ISO TC 206 have taken a lead role in the standardization of testing for ceramics, and recent efforts and needs in standards development by Committee C28 on Advanced Ceramics will be summarized. In some cases, the engineers, etc. involved are unaware of the latest developments, and traditional approaches applicable to other material systems are applied. Two examples of flight hardware failures that might have been prevented via education and standardization will be presented.

Center of Excellence for Hypersonics Research

DTIC Science & Technology

2012-01-25

detailed simulations of actual combustor configurations, and ultimately for the optimization of hypersonic air - breathing propulsion system flow paths... vehicle development programs. The Center engaged leading experts in experimental and computational analysis of hypersonic flows to provide research...advanced hypersonic vehicles and space access systems will require significant advances in the design methods and ground testing techniques to ensure

Factors Affecting Long-Term-Care Residents' Decision-Making Processes as They Formulate Advance Directives

ERIC Educational Resources Information Center

Lambert, Heather C.; McColl, Mary Ann; Gilbert, Julie; Wong, Jiahui; Murray, Gale; Shortt, Samuel E. D.

2005-01-01

Purpose: The purpose of this study was to describe factors contributing to the decision-making processes of elderly persons as they formulate advance directives in long-term care. Design and Methods: This study was qualitative, based on grounded theory. Recruitment was purposive and continued until saturation was reached. Nine residents of a…

Characterizing Design Learning through the Use of Language: A Mixed-Methods Study of Engineering Designers. Research Brief

ERIC Educational Resources Information Center

Atman, Cindy; Kilgore, Deborah; McKenna, Ann

2009-01-01

This analysis, that utilizes data from part of the Academic Pathways Study (APS) of the Center for the Advancement of Engineering Education (CAEE), found that as a result of taking a course in engineering design and/or studying engineering for four years, students acquire engineering design language that is common to a larger community of practice…

Design and Analysis Tools for Supersonic Inlets

NASA Technical Reports Server (NTRS)

Slater, John W.; Folk, Thomas C.

2009-01-01

Computational tools are being developed for the design and analysis of supersonic inlets. The objective is to update existing tools and provide design and low-order aerodynamic analysis capability for advanced inlet concepts. The Inlet Tools effort includes aspects of creating an electronic database of inlet design information, a document describing inlet design and analysis methods, a geometry model for describing the shape of inlets, and computer tools that implement the geometry model and methods. The geometry model has a set of basic inlet shapes that include pitot, two-dimensional, axisymmetric, and stream-traced inlet shapes. The inlet model divides the inlet flow field into parts that facilitate the design and analysis methods. The inlet geometry model constructs the inlet surfaces through the generation and transformation of planar entities based on key inlet design factors. Future efforts will focus on developing the inlet geometry model, the inlet design and analysis methods, a Fortran 95 code to implement the model and methods. Other computational platforms, such as Java, will also be explored.

Reliability enhancement of APR + diverse protection system regarding common cause failures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Oh, Y. G.; Kim, Y. M.; Yim, H. S.

2012-07-01

The Advanced Power Reactor Plus (APR +) nuclear power plant design has been developed on the basis of the APR1400 (Advanced Power Reactor 1400 MWe) to further enhance safety and economics. For the mitigation of Anticipated Transients Without Scram (ATWS) as well as Common Cause Failures (CCF) within the Plant Protection System (PPS) and the Emergency Safety Feature - Component Control System (ESF-CCS), several design improvement features have been implemented for the Diverse Protection System (DPS) of the APR + plant. As compared to the APR1400 DPS design, the APR + DPS has been designed to provide the Safety Injectionmore » Actuation Signal (SIAS) considering a large break LOCA accident concurrent with the CCF. Additionally several design improvement features, such as channel structure with redundant processing modules, and changes of system communication methods and auto-system test methods, are introduced to enhance the functional reliability of the DPS. Therefore, it is expected that the APR + DPS can provide an enhanced safety and reliability regarding possible CCF in the safety-grade I and C systems as well as the DPS itself. (authors)« less

Fabrication of liquid-rocket thrust chambers by electroforming

NASA Technical Reports Server (NTRS)

Duscha, R. A.; Kazaroff, J. M.

1974-01-01

Electroforming has proven to be an excellent fabrication method for building liquid rocket regeneratively cooled thrust chambers. NASA sponsored technology programs have investigated both common and advanced methods. Using common procedures, several cooled spool pieces and thrust chambers have been made and successfully tested. The designs were made possible through the versatility of the electroforming procedure, which is not limited to simple geometric shapes. An advanced method of electroforming was used to produce a wire-wrapped, composite, pressure-loaded electroformed structure, which greatly increased the strength of the structure while still retaining the advantages of electroforming.

Composite structural materials. [aircraft applications

NASA Technical Reports Server (NTRS)

Ansell, G. S.; Loewy, R. G.; Wiberley, S. E.

1981-01-01

The development of composite materials for aircraft applications is addressed with specific consideration of physical properties, structural concepts and analysis, manufacturing, reliability, and life prediction. The design and flight testing of composite ultralight gliders is documented. Advances in computer aided design and methods for nondestructive testing are also discussed.

Integrating Materials, Manufacturing, Design and Validation for Sustainability in Future Transport Systems

NASA Astrophysics Data System (ADS)

Price, M. A.; Murphy, A.; Butterfield, J.; McCool, R.; Fleck, R.

2011-05-01

The predictive methods currently used for material specification, component design and the development of manufacturing processes, need to evolve beyond the current `metal centric' state of the art, if advanced composites are to realise their potential in delivering sustainable transport solutions. There are however, significant technical challenges associated with this process. Deteriorating environmental, political, economic and social conditions across the globe have resulted in unprecedented pressures to improve the operational efficiency of the manufacturing sector generally and to change perceptions regarding the environmental credentials of transport systems in particular. There is a need to apply new technologies and develop new capabilities to ensure commercial sustainability in the face of twenty first century economic and climatic conditions as well as transport market demands. A major technology gap exists between design, analysis and manufacturing processes in both the OEMs, and the smaller companies that make up the SME based supply chain. As regulatory requirements align with environmental needs, manufacturers are increasingly responsible for the broader lifecycle aspects of vehicle performance. These include not only manufacture and supply but disposal and re-use or re-cycling. In order to make advances in the reduction of emissions coupled with improved economic efficiency through the provision of advanced lightweight vehicles, four key challenges are identified as follows: Material systems, Manufacturing systems, Integrated design methods using digital manufacturing tools and Validation systems. This paper presents a project which has been designed to address these four key issues, using at its core, a digital framework for the creation and management of key parameters related to the lifecycle performance of thermoplastic composite parts and structures. It aims to provide capability for the proposition, definition, evaluation and demonstration of advanced lightweight structures for new generation vehicles in the context of whole life performance parameters.

Statistical metrology—measurement and modeling of variation for advanced process development and design rule generation

NASA Astrophysics Data System (ADS)

Boning, Duane S.; Chung, James E.

1998-11-01

Advanced process technology will require more detailed understanding and tighter control of variation in devices and interconnects. The purpose of statistical metrology is to provide methods to measure and characterize variation, to model systematic and random components of that variation, and to understand the impact of variation on both yield and performance of advanced circuits. Of particular concern are spatial or pattern-dependencies within individual chips; such systematic variation within the chip can have a much larger impact on performance than wafer-level random variation. Statistical metrology methods will play an important role in the creation of design rules for advanced technologies. For example, a key issue in multilayer interconnect is the uniformity of interlevel dielectric (ILD) thickness within the chip. For the case of ILD thickness, we describe phases of statistical metrology development and application to understanding and modeling thickness variation arising from chemical-mechanical polishing (CMP). These phases include screening experiments including design of test structures and test masks to gather electrical or optical data, techniques for statistical decomposition and analysis of the data, and approaches to calibrating empirical and physical variation models. These models can be integrated with circuit CAD tools to evaluate different process integration or design rule strategies. One focus for the generation of interconnect design rules are guidelines for the use of "dummy fill" or "metal fill" to improve the uniformity of underlying metal density and thus improve the uniformity of oxide thickness within the die. Trade-offs that can be evaluated via statistical metrology include the improvements to uniformity possible versus the effect of increased capacitance due to additional metal.

From molecules to management: adopting DNA-based methods for monitoring biological invasions in aquatic environments

EPA Science Inventory

Recent technological advances have driven rapid development of DNA-based methods designed to facilitate detection and monitoring of invasive species in aquatic environments. These tools promise to significantly alleviate difficulties associated with traditional monitoring approac...

Projected role of advanced computational aerodynamic methods at the Lockheed-Georgia company

NASA Technical Reports Server (NTRS)

Lores, M. E.

1978-01-01

Experience with advanced computational methods being used at the Lockheed-Georgia Company to aid in the evaluation and design of new and modified aircraft indicates that large and specialized computers will be needed to make advanced three-dimensional viscous aerodynamic computations practical. The Numerical Aerodynamic Simulation Facility should be used to provide a tool for designing better aerospace vehicles while at the same time reducing development costs by performing computations using Navier-Stokes equations solution algorithms and permitting less sophisticated but nevertheless complex calculations to be made efficiently. Configuration definition procedures and data output formats can probably best be defined in cooperation with industry, therefore, the computer should handle many remote terminals efficiently. The capability of transferring data to and from other computers needs to be provided. Because of the significant amount of input and output associated with 3-D viscous flow calculations and because of the exceedingly fast computation speed envisioned for the computer, special attention should be paid to providing rapid, diversified, and efficient input and output.

Reflections on experimental research in medical education.

PubMed

Cook, David A; Beckman, Thomas J

2010-08-01

As medical education research advances, it is important that education researchers employ rigorous methods for conducting and reporting their investigations. In this article we discuss several important yet oft neglected issues in designing experimental research in education. First, randomization controls for only a subset of possible confounders. Second, the posttest-only design is inherently stronger than the pretest-posttest design, provided the study is randomized and the sample is sufficiently large. Third, demonstrating the superiority of an educational intervention in comparison to no intervention does little to advance the art and science of education. Fourth, comparisons involving multifactorial interventions are hopelessly confounded, have limited application to new settings, and do little to advance our understanding of education. Fifth, single-group pretest-posttest studies are susceptible to numerous validity threats. Finally, educational interventions (including the comparison group) must be described in detail sufficient to allow replication.

Preliminary aerodynamic design considerations for advanced laminar flow aircraft configurations

NASA Technical Reports Server (NTRS)

Johnson, Joseph L., Jr.; Yip, Long P.; Jordan, Frank L., Jr.

1986-01-01

Modern composite manufacturing methods have provided the opportunity for smooth surfaces that can sustain large regions of natural laminar flow (NLF) boundary layer behavior and have stimulated interest in developing advanced NLF airfoils and improved aircraft designs. Some of the preliminary results obtained in exploratory research investigations on advanced aircraft configurations at the NASA Langley Research Center are discussed. Results of the initial studies have shown that the aerodynamic effects of configuration variables such as canard/wing arrangements, airfoils, and pusher-type and tractor-type propeller installations can be particularly significant at high angles of attack. Flow field interactions between aircraft components were shown to produce undesirable aerodynamic effects on a wing behind a heavily loaded canard, and the use of properly designed wing leading-edge modifications, such as a leading-edge droop, offset the undesirable aerodynamic effects by delaying wing stall and providing increased stall/spin resistance with minimum degradation of laminar flow behavior.

Computerized structural mechanics for 1990's: Advanced aircraft needs

NASA Technical Reports Server (NTRS)

Viswanathan, A. V.; Backman, B. F.

1989-01-01

The needs for computerized structural mechanics (CSM) as seen from the standpoint of the aircraft industry are discussed. These needs are projected into the 1990's with special focus on the new advanced materials. Preliminary design/analysis, research, and detail design/analysis are identified as major areas. The role of local/global analyses in these different areas is discussed. The lessons learned in the past are used as a basis for the design of a CSM framework that could modify and consolidate existing technology and include future developments in a rational and useful way. A philosophy is stated, and a set of analyses needs driven by the emerging advanced composites is enumerated. The roles of NASA, the universities, and the industry are identified. Finally, a set of rational research targets is recommended based on both the new types of computers and the increased complexity the industry faces. Computerized structural mechanics should be more than new methods in structural mechanics and numerical analyses. It should be a set of engineering applications software products that combines innovations in structural mechanics, numerical analysis, data processing, search and display features, and recent hardware advances and is organized in a framework that directly supports the design process.

Advanced Combustion Numerics and Modeling - FY18 First Quarter Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitesides, R. A.; Killingsworth, N. J.; McNenly, M. J.

This project is focused on early stage research and development of numerical methods and models to improve advanced engine combustion concepts and systems. The current focus is on development of new mathematics and algorithms to reduce the time to solution for advanced combustion engine design using detailed fuel chemistry. The research is prioritized towards the most time-consuming workflow bottlenecks (computer and human) and accuracy gaps that slow ACS program members. Zero-RK, the fast and accurate chemical kinetics solver software developed in this project, is central to the research efforts and continues to be developed to address the current and emergingmore » needs of the engine designers, engine modelers and fuel mechanism developers.« less

The synergistic use of computation, chemistry and biology to discover novel peptide-based drugs: the time is right.

PubMed

Audie, J; Boyd, C

2010-01-01

The case for peptide-based drugs is compelling. Due to their chemical, physical and conformational diversity, and relatively unproblematic toxicity and immunogenicity, peptides represent excellent starting material for drug discovery. Nature has solved many physiological and pharmacological problems through the use of peptides, polypeptides and proteins. If nature could solve such a diversity of challenging biological problems through the use of peptides, it seems reasonable to infer that human ingenuity will prove even more successful. And this, indeed, appears to be the case, as a number of scientific and methodological advances are making peptides and peptide-based compounds ever more promising pharmacological agents. Chief among these advances are powerful chemical and biological screening technologies for lead identification and optimization, methods for enhancing peptide in vivo stability, bioavailability and cell-permeability, and new delivery technologies. Other advances include the development and experimental validation of robust computational methods for peptide lead identification and optimization. Finally, scientific analysis, biology and chemistry indicate the prospect of designing relatively small peptides to therapeutically modulate so-called 'undruggable' protein-protein interactions. Taken together a clear picture is emerging: through the synergistic use of the scientific imagination and the computational, chemical and biological methods that are currently available, effective peptide therapeutics for novel targets can be designed that surpass even the proven peptidic designs of nature.

Real-time 2D spatially selective MRI experiments: Comparative analysis of optimal control design methods

NASA Astrophysics Data System (ADS)

Maximov, Ivan I.; Vinding, Mads S.; Tse, Desmond H. Y.; Nielsen, Niels Chr.; Shah, N. Jon

2015-05-01

There is an increasing need for development of advanced radio-frequency (RF) pulse techniques in modern magnetic resonance imaging (MRI) systems driven by recent advancements in ultra-high magnetic field systems, new parallel transmit/receive coil designs, and accessible powerful computational facilities. 2D spatially selective RF pulses are an example of advanced pulses that have many applications of clinical relevance, e.g., reduced field of view imaging, and MR spectroscopy. The 2D spatially selective RF pulses are mostly generated and optimised with numerical methods that can handle vast controls and multiple constraints. With this study we aim at demonstrating that numerical, optimal control (OC) algorithms are efficient for the design of 2D spatially selective MRI experiments, when robustness towards e.g. field inhomogeneity is in focus. We have chosen three popular OC algorithms; two which are gradient-based, concurrent methods using first- and second-order derivatives, respectively; and a third that belongs to the sequential, monotonically convergent family. We used two experimental models: a water phantom, and an in vivo human head. Taking into consideration the challenging experimental setup, our analysis suggests the use of the sequential, monotonic approach and the second-order gradient-based approach as computational speed, experimental robustness, and image quality is key. All algorithms used in this work were implemented in the MATLAB environment and are freely available to the MRI community.

Does human cognition allow Human Factors (HF) certification of advanced aircrew systems?

NASA Technical Reports Server (NTRS)

Macleod, Iain S.; Taylor, Robert M.

1994-01-01

This paper has examined the requirements of HF specification and certification within advanced or complex aircrew systems. It suggests reasons for current inadequacies in the use of HF in the design process, giving some examples in support, and suggesting an avenue towards the improvement of the HF certification process. The importance of human cognition to the operation and performance of advanced aircrew systems has been stressed. Many of the shortfalls of advanced aircrew systems must be attributed to over automated designs that show little consideration on either the mental limits or the cognitive capabilities of the human system component. Traditional approaches to system design and HF certification are set within an over physicalistic foundation. Also, traditionally it was assumed that physicalistic system functions could be attributed to either the human or the machine on a one to one basis. Moreover, any problems associated with the parallel needs, or promoting human understanding alongside system operation and direction, were generally equated in reality by the natural flexibility and adaptability of human skills. The consideration of the human component of a complex system is seen as being primarily based on manifestations of human behavior to the almost total exclusion of any appreciation of unobservable human mental and cognitive processes. The argument of this paper is that the considered functionality of any complex human-machine system must contain functions that are purely human and purely cognitive. Human-machine system reliability ultimately depends on human reliability and dependability and, therefore, on the form and frequency of cognitive processes that have to be conducted to support system performance. The greater the demand placed by an advanced aircraft system on the human component's basic knowledge processes or cognition, rather than on skill, the more insiduous the effects the human may have on that system. This paper discusses one example of an attempt to devise an improved method of specificaiton and certification with relation to the advanced aircrew system, that of the RN Merlin helicopter. The method is realized to have limitations in practice, these mainly associated with the late production of the system specification in relation to the system development process. The need for a careful appreciation of the capabilities and support needs of human cognition within the design process of a complex man machine system has been argued, especially with relation to the concept of system functionality. Unlike the physicalistic Fitts list, a new classification of system functionality is proposed, namely: (1) equipment - system equipment related; (2) cognitive - human cognition related; and (3) associated - necessary combinatin of equipment and cognitive. This paper has not proposed a method for a fuller consideration of cognition within systems design, but has suggested the need for such a method and indicated an avenue towards its development. Finally, the HF certification of advanced aircrew systems is seen as only being possible in a qualified sense until the important functions of human cognition are considered within the system design process. (This paper contains the opinions of its authors and does not necessarily refledt the standpoint of their respective organizations).

Advances in Statistical Methods for Substance Abuse Prevention Research

PubMed Central

MacKinnon, David P.; Lockwood, Chondra M.

2010-01-01

The paper describes advances in statistical methods for prevention research with a particular focus on substance abuse prevention. Standard analysis methods are extended to the typical research designs and characteristics of the data collected in prevention research. Prevention research often includes longitudinal measurement, clustering of data in units such as schools or clinics, missing data, and categorical as well as continuous outcome variables. Statistical methods to handle these features of prevention data are outlined. Developments in mediation, moderation, and implementation analysis allow for the extraction of more detailed information from a prevention study. Advancements in the interpretation of prevention research results include more widespread calculation of effect size and statistical power, the use of confidence intervals as well as hypothesis testing, detailed causal analysis of research findings, and meta-analysis. The increased availability of statistical software has contributed greatly to the use of new methods in prevention research. It is likely that the Internet will continue to stimulate the development and application of new methods. PMID:12940467

Designing an Advanced Instructional Design Advisor: Possibilities for Automation. Volume 3

DTIC Science & Technology

1991-05-01

system (Spec. Rep. NPRDC- SR-83-13). San Diego, CA: Navy Personnel Research and Development Center. Dawkins , R. (1976). The selfish gene . Oxford...instructional methods that keep the idea alive will change in corresponding ways. (See Dawkins (1976) for a discussion of related ideas.) The implications of

Procedure for analysis and design of weaving sections : volume 1, research findings and development of techniques for application.

DOT National Transportation Integrated Search

1983-12-01

This research was performed to complete and advance the status of recently developed : procedures for analysis and design of weaving sections (known as the Leisch method and-initially published in the 1979 issue of ITE Journal). The objective was to ...

Designing for fiber composite structural durability in hygrothermomechanical environment

NASA Technical Reports Server (NTRS)

Chamis, C. C.

1985-01-01

A methodology is described which can be used to design/analyze fiber composite structures subjected to complex hygrothermomechanical environments. This methodology includes composite mechanics and advanced structural analysis methods (finite element). Select examples are described to illustrate the application of the available methodology. The examples include: (1) composite progressive fracture; (2) composite design for high cycle fatigue combined with hot-wet conditions; and (3) general laminate design.

Applications of Advanced Experimental Methodologies to AWAVS Training Research. Final Report, May 1977-July 1978.

ERIC Educational Resources Information Center

Simon, Charles W.

A major part of the Naval Training Equipment Center's Aviation Wide Angle Visual System (AWAVS) program involves behavioral research to provide a basis for establishing design criteria for flight trainers. As part of the task of defining the purpose and approach of this program, the applications of advanced experimental methods are explained and…

Rapid Analysis and Manufacturing Propulsion Technology (RAMPT)

NASA Technical Reports Server (NTRS)

Fikes, John C.

2018-01-01

NASA's strategic plan calls for the development of enabling technologies, improved production methods, and advanced design and analysis tools related to the agency's objectives to expand human presence in the solar system. NASA seeks to advance exploration, science, innovation, benefits to humanity, and international collaboration, as well as facilitate and utilize U.S. commercial capabilities to deliver cargo and crew to space.

The Effects of Using Concept Mapping for Improving Advanced Level Biology Students' Lower- and Higher-Order Cognitive Skills

ERIC Educational Resources Information Center

Bramwell-Lalor, Sharon; Rainford, Marcia

2014-01-01

This paper reports on teachers' use of concept mapping as an alternative assessment strategy in advanced level biology classes and its effects on students' cognitive skills on selected biology concepts. Using a mixed methods approach, the study employed a pre-test/post-test quasi-experimental design involving 156 students and 8 teachers from…

Clinical Trial Design for HIV Prevention Research: Determining Standards of Prevention.

PubMed

Dawson, Liza; Zwerski, Sheryl

2015-06-01

This article seeks to advance ethical dialogue on choosing standards of prevention in clinical trials testing improved biomedical prevention methods for HIV. The stakes in this area of research are high, given the continued high rates of infection in many countries and the budget limitations that have constrained efforts to expand treatment for all who are currently HIV-infected. New prevention methods are still needed; at the same time, some existing prevention and treatment interventions have been proven effective but are not yet widely available in the countries where they most urgently needed. The ethical tensions in this field of clinical research are well known and have been the subject of extensive debate. There is no single clinical trial design that can optimize all the ethically important goals and commitments involved in research. Several recent articles have described the current ethical difficulties in designing HIV prevention trials, especially in resource limited settings; however, there is no consensus on how to handle clinical trial design decisions, and existing international ethical guidelines offer conflicting advice. This article acknowledges these deep ethical dilemmas and moves beyond a simple descriptive approach to advance an organized method for considering what clinical trial designs will be ethically acceptable for HIV prevention trials, balancing the relevant criteria and providing justification for specific design decisions. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.

Application of the finite element method in orthopedic implant design.

PubMed

Saha, Subrata; Roychowdhury, Amit

2009-01-01

The finite element method (FEM) was first introduced to the field of orthopedic biomechanics in the early 1970s to evaluate stresses in human bones. By the early 1980s, the method had become well established as a tool for basic research and design analysis. Since the late 1980s and early 1990s, FEM has also been used to study bone remodeling. Today, it is one of the most reliable simulation tools for evaluating wear, fatigue, crack propagation, and so forth, and is used in many types of preoperative testing. Since the introduction of FEM to orthopedic biomechanics, there have been rapid advances in computer processing speeds, the finite element and other numerical methods, understanding of mechanical properties of soft and hard tissues and their modeling, and image-processing techniques. In light of these advances, it is accepted today that FEM will continue to contribute significantly to further progress in the design and development of orthopedic implants, as well as in the understanding of other complex systems of the human body. In the following article, different main application areas of finite element simulation will be reviewed including total hip joint arthroplasty, followed by the knee, spine, shoulder, and elbow, respectively.

The NASA Lewis large wind turbine program

NASA Technical Reports Server (NTRS)

Thomas, R. L.; Baldwin, D. H.

1981-01-01

The program is directed toward development of the technology for safe, reliable, environmentally acceptable large wind turbines that have the potential to generate a significant amount of electricity at costs competitive with conventional electric generation systems. In addition, these large wind turbines must be fully compatible with electric utility operations and interface requirements. Advances are made by gaining a better understanding of the system design drivers, improvements in the analytical design tools, verification of design methods with operating field data, and the incorporation of new technology and innovative designs. An overview of the program activities is presented and includes results from the first and second generation field machines (Mod-OA, -1, and -2), the design phase of the third generation wind turbine (Mod-5) and the advanced technology projects. Also included is the status of the Department of Interior WTS-4 machine.

Printing, folding and assembly methods for forming 3D mesostructures in advanced materials

NASA Astrophysics Data System (ADS)

Zhang, Yihui; Zhang, Fan; Yan, Zheng; Ma, Qiang; Li, Xiuling; Huang, Yonggang; Rogers, John A.

2017-03-01

A rapidly expanding area of research in materials science involves the development of routes to complex 3D structures with feature sizes in the mesoscopic range (that is, between tens of nanometres and hundreds of micrometres). A goal is to establish methods for controlling the properties of materials systems and the function of devices constructed with them, not only through chemistry and morphology, but also through 3D architectures. The resulting systems, sometimes referred to as metamaterials, offer engineered behaviours with optical, thermal, acoustic, mechanical and electronic properties that do not occur in the natural world. Impressive advances in 3D printing techniques represent some of the most broadly recognized developments in this field, but recent successes with strategies based on concepts in origami, kirigami and deterministic assembly provide additional, unique options in 3D design and high-performance materials. In this Review, we highlight the latest progress and trends in methods for fabricating 3D mesostructures, beginning with the development of advanced material inks for nozzle-based approaches to 3D printing and new schemes for 3D optical patterning. In subsequent sections, we summarize more recent methods based on folding, rolling and mechanical assembly, including their application with materials such as designer hydrogels, monocrystalline inorganic semiconductors and graphene.

Mask manufacturing of advanced technology designs using multi-beam lithography (Part 1)

NASA Astrophysics Data System (ADS)

Green, Michael; Ham, Young; Dillon, Brian; Kasprowicz, Bryan; Hur, Ik Boum; Park, Joong Hee; Choi, Yohan; McMurran, Jeff; Kamberian, Henry; Chalom, Daniel; Klikovits, Jan; Jurkovic, Michal; Hudek, Peter

2016-10-01

As optical lithography is extended into 10nm and below nodes, advanced designs are becoming a key challenge for mask manufacturers. Techniques including advanced Optical Proximity Correction (OPC) and Inverse Lithography Technology (ILT) result in structures that pose a range of issues across the mask manufacturing process. Among the new challenges are continued shrinking Sub-Resolution Assist Features (SRAFs), curvilinear SRAFs, and other complex mask geometries that are counter-intuitive relative to the desired wafer pattern. Considerable capability improvements over current mask making methods are necessary to meet the new requirements particularly regarding minimum feature resolution and pattern fidelity. Advanced processes using the IMS Multi-beam Mask Writer (MBMW) are feasible solutions to these coming challenges. In this paper, we study one such process, characterizing mask manufacturing capability of 10nm and below structures with particular focus on minimum resolution and pattern fidelity.

Investigation of an advanced fault tolerant integrated avionics system

NASA Technical Reports Server (NTRS)

Dunn, W. R.; Cottrell, D.; Flanders, J.; Javornik, A.; Rusovick, M.

1986-01-01

Presented is an advanced, fault-tolerant multiprocessor avionics architecture as could be employed in an advanced rotorcraft such as LHX. The processor structure is designed to interface with existing digital avionics systems and concepts including the Army Digital Avionics System (ADAS) cockpit/display system, navaid and communications suites, integrated sensing suite, and the Advanced Digital Optical Control System (ADOCS). The report defines mission, maintenance and safety-of-flight reliability goals as might be expected for an operational LHX aircraft. Based on use of a modular, compact (16-bit) microprocessor card family, results of a preliminary study examining simplex, dual and standby-sparing architectures is presented. Given the stated constraints, it is shown that the dual architecture is best suited to meet reliability goals with minimum hardware and software overhead. The report presents hardware and software design considerations for realizing the architecture including redundancy management requirements and techniques as well as verification and validation needs and methods.

GLOBECOM '89 - IEEE Global Telecommunications Conference and Exhibition, Dallas, TX, Nov. 27-30, 1989, Conference Record. Volumes 1, 2, & 3

NASA Astrophysics Data System (ADS)

The present conference discusses topics in multiwavelength network technology and its applications, advanced digital radio systems in their propagation environment, mobile radio communications, switching programmability, advancements in computer communications, integrated-network management and security, HDTV and image processing in communications, basic exchange communications radio advancements in digital switching, intelligent network evolution, speech coding for telecommunications, and multiple access communications. Also discussed are network designs for quality assurance, recent progress in coherent optical systems, digital radio applications, advanced communications technologies for mobile users, communication software for switching systems, AI and expert systems in network management, intelligent multiplexing nodes, video and image coding, network protocols and performance, system methods in quality and reliability, the design and simulation of lightwave systems, local radio networks, mobile satellite communications systems, fiber networks restoration, packet video networks, human interfaces for future networks, and lightwave networking.

Leveraging advances in biology to design biomaterials

NASA Astrophysics Data System (ADS)

Darnell, Max; Mooney, David J.

2017-12-01

Biomaterials have dramatically increased in functionality and complexity, allowing unprecedented control over the cells that interact with them. From these engineering advances arises the prospect of improved biomaterial-based therapies, yet practical constraints favour simplicity. Tools from the biology community are enabling high-resolution and high-throughput bioassays that, if incorporated into a biomaterial design framework, could help achieve unprecedented functionality while minimizing the complexity of designs by identifying the most important material parameters and biological outputs. However, to avoid data explosions and to effectively match the information content of an assay with the goal of the experiment, material screens and bioassays must be arranged in specific ways. By borrowing methods to design experiments and workflows from the bioprocess engineering community, we outline a framework for the incorporation of next-generation bioassays into biomaterials design to effectively optimize function while minimizing complexity. This framework can inspire biomaterials designs that maximize functionality and translatability.

NASA gear research and its probable effect on rotorcraft transmission design

NASA Technical Reports Server (NTRS)

Zaretsky, E. V.; Townsend, D. P.; Coy, J. J.

1979-01-01

The NASA Lewis Research Center devised a comprehensive gear technology research program beginning in 1969, the results of which are being integrated into the NASA civilian Helicopter Transmission System Technology Program. Attention is given to the results of this gear research and those programs which are presently being undertaken. In addition, research programs studying pitting fatigue, gear steels and processing, life prediction methods, gear design and dynamics, elastohydrodynamic lubrication, lubrication methods and gear noise are presented. Finally, the impact of advanced gear research technology on rotorcraft transmission design is discussed.

Challenges and Opportunities for Research on Same-Sex Relationships

PubMed Central

Umberson, Debra; Thomeer, Mieke Beth; Kroeger, Rhiannon A.; Lodge, Amy Caroline; Xu, Minle

2014-01-01

Research on same-sex relationships has informed policy debates and legal decisions that greatly affect American families, yet the data and methods available to scholars studying same-sex relationships have been limited. In this article the authors review current approaches to studying same-sex relationships and significant challenges for this research. After exploring how researchers have dealt with these challenges in prior studies, the authors discuss promising strategies and methods to advance future research on same-sex relationships, with particular attention given to gendered contexts and dyadic research designs, quasi-experimental designs, and a relationship biography approach. Innovation and advances in the study of same-sex relationships will further theoretical and empirical knowledge in family studies more broadly and increase understanding of different-sex as well as same-sex relationships. PMID:25598552

Aircraft engine pollution reduction.

NASA Technical Reports Server (NTRS)

Rudey, R. A.

1972-01-01

The effect of engine operation on the types and levels of the major aircraft engine pollutants is described and the major factors governing the formation of these pollutants during the burning of hydrocarbon fuel are discussed. Methods which are being explored to reduce these pollutants are discussed and their application to several experimental research programs are pointed out. Results showing significant reductions in the levels of carbon monoxide, unburned hydrocarbons, and oxides of nitrogen obtained from experimental combustion research programs are presented and discussed to point out potential application to aircraft engines. An experimental program designed to develop and demonstrate these and other advanced, low pollution combustor design methods is described. Results that have been obtained to date indicate considerable promise for reducing advanced engine exhaust pollutants to levels significantly below current engines.

Advanced Software V&V for Civil Aviation and Autonomy

NASA Technical Reports Server (NTRS)

Brat, Guillaume P.

2017-01-01

With the advances in high-computing platform (e.g., advanced graphical processing units or multi-core processors), computationally-intensive software techniques such as the ones used in artificial intelligence or formal methods have provided us with an opportunity to further increase safety in the aviation industry. Some of these techniques have facilitated building safety at design time, like in aircraft engines or software verification and validation, and others can introduce safety benefits during operations as long as we adapt our processes. In this talk, I will present how NASA is taking advantage of these new software techniques to build in safety at design time through advanced software verification and validation, which can be applied earlier and earlier in the design life cycle and thus help also reduce the cost of aviation assurance. I will then show how run-time techniques (such as runtime assurance or data analytics) offer us a chance to catch even more complex problems, even in the face of changing and unpredictable environments. These new techniques will be extremely useful as our aviation systems become more complex and more autonomous.

The Design of a Primary Flight Trainer using Concurrent Engineering Concepts

NASA Technical Reports Server (NTRS)

Ladesic, James G.; Eastlake, Charles N.; Kietzmann, Nicholas H.

1993-01-01

Concurrent Engineering (CE) concepts seek to coordinate the expertise of various disciplines from initial design configuration selection through product disposal so that cost efficient design solutions may be achieve. Integrating this methodology into an undergraduate design course sequence may provide a needed enhancement to engineering education. The Advanced Design Program (ADP) project at Embry-Riddle Aeronautical University (EMU) is focused on developing recommendations for the general aviation Primary Flight Trainer (PFT) of the twenty first century using methods of CE. This project, over the next two years, will continue synthesizing the collective knowledge of teams composed of engineering students along with students from other degree programs, their faculty, and key industry representatives. During the past year (Phase I). conventional trainer configurations that comply with current regulations and existing technologies have been evaluated. Phase I efforts have resulted in two baseline concepts, a high-wing, conventional design named Triton and a low-wing, mid-engine configuration called Viper. In the second and third years (Phases II and III). applications of advanced propulsion, advanced materials, and unconventional airplane configurations along with military and commercial technologies which are anticipated to be within the economic range of general aviation by the year 2000, will be considered.

Propensity Scores in Pharmacoepidemiology: Beyond the Horizon.

PubMed

Jackson, John W; Schmid, Ian; Stuart, Elizabeth A

2017-12-01

Propensity score methods have become commonplace in pharmacoepidemiology over the past decade. Their adoption has confronted formidable obstacles that arise from pharmacoepidemiology's reliance on large healthcare databases of considerable heterogeneity and complexity. These include identifying clinically meaningful samples, defining treatment comparisons, and measuring covariates in ways that respect sound epidemiologic study design. Additional complexities involve correctly modeling treatment decisions in the face of variation in healthcare practice, and dealing with missing information and unmeasured confounding. In this review, we examine the application of propensity score methods in pharmacoepidemiology with particular attention to these and other issues, with an eye towards standards of practice, recent methodological advances, and opportunities for future progress. Propensity score methods have matured in ways that can advance comparative effectiveness and safety research in pharmacoepidemiology. These include natural extensions for categorical treatments, matching algorithms that can optimize sample size given design constraints, weighting estimators that asymptotically target matched and overlap samples, and the incorporation of machine learning to aid in covariate selection and model building. These recent and encouraging advances should be further evaluated through simulation and empirical studies, but nonetheless represent a bright path ahead for the observational study of treatment benefits and harms.

PD-atricians: Leveraging Physicians and Participatory Design to Develop Novel Clinical Information Tools

PubMed Central

Pollack, Ari H; Miller, Andrew; Mishra, Sonali R.; Pratt, Wanda

2016-01-01

Participatory design, a method by which system users and stakeholders meaningfully contribute to the development of a new process or technology, has great potential to revolutionize healthcare technology, yet has seen limited adoption. We conducted a design session with eleven physicians working to create a novel clinical information tool utilizing participatory design methods. During the two-hour session, the physicians quickly engaged in the process and generated a large quantity of information, informing the design of a future tool. By utilizing facilitators experienced in design methodology, with detailed domain expertise, and well integrated into the healthcare organization, the participatory design session engaged a group of users who are often disenfranchised with existing processes as well as health information technology in general. We provide insight into why participatory design works with clinicians and provide guiding principles for how to implement these methods in healthcare organizations interested in advancing health information technology. PMID:28269900

Incorporating 3D-printing technology in the design of head-caps and electrode drives for recording neurons in multiple brain regions.

PubMed

Headley, Drew B; DeLucca, Michael V; Haufler, Darrell; Paré, Denis

2015-04-01

Recent advances in recording and computing hardware have enabled laboratories to record the electrical activity of multiple brain regions simultaneously. Lagging behind these technical advances, however, are the methods needed to rapidly produce microdrives and head-caps that can flexibly accommodate different recording configurations. Indeed, most available designs target single or adjacent brain regions, and, if multiple sites are targeted, specially constructed head-caps are used. Here, we present a novel design style, for both microdrives and head-caps, which takes advantage of three-dimensional printing technology. This design facilitates targeting of multiple brain regions in various configurations. Moreover, the parts are easily fabricated in large quantities, with only minor hand-tooling and finishing required. Copyright © 2015 the American Physiological Society.

Incorporating 3D-printing technology in the design of head-caps and electrode drives for recording neurons in multiple brain regions

PubMed Central

DeLucca, Michael V.; Haufler, Darrell; Paré, Denis

2015-01-01

Recent advances in recording and computing hardware have enabled laboratories to record the electrical activity of multiple brain regions simultaneously. Lagging behind these technical advances, however, are the methods needed to rapidly produce microdrives and head-caps that can flexibly accommodate different recording configurations. Indeed, most available designs target single or adjacent brain regions, and, if multiple sites are targeted, specially constructed head-caps are used. Here, we present a novel design style, for both microdrives and head-caps, which takes advantage of three-dimensional printing technology. This design facilitates targeting of multiple brain regions in various configurations. Moreover, the parts are easily fabricated in large quantities, with only minor hand-tooling and finishing required. PMID:25652930

Modified Fully Utilized Design (MFUD) Method for Stress and Displacement Constraints

NASA Technical Reports Server (NTRS)

Patnaik, Surya; Gendy, Atef; Berke, Laszlo; Hopkins, Dale

1997-01-01

The traditional fully stressed method performs satisfactorily for stress-limited structural design. When this method is extended to include displacement limitations in addition to stress constraints, it is known as the fully utilized design (FUD). Typically, the FUD produces an overdesign, which is the primary limitation of this otherwise elegant method. We have modified FUD in an attempt to alleviate the limitation. This new method, called the modified fully utilized design (MFUD) method, has been tested successfully on a number of designs that were subjected to multiple loads and had both stress and displacement constraints. The solutions obtained with MFUD compare favorably with the optimum results that can be generated by using nonlinear mathematical programming techniques. The MFUD method appears to have alleviated the overdesign condition and offers the simplicity of a direct, fully stressed type of design method that is distinctly different from optimization and optimality criteria formulations. The MFUD method is being developed for practicing engineers who favor traditional design methods rather than methods based on advanced calculus and nonlinear mathematical programming techniques. The Integrated Force Method (IFM) was found to be the appropriate analysis tool in the development of the MFUD method. In this paper, the MFUD method and its optimality are presented along with a number of illustrative examples.

Analysis of tasks for dynamic man/machine load balancing in advanced helicopters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jorgensen, C.C.

1987-10-01

This report considers task allocation requirements imposed by advanced helicopter designs incorporating mixes of human pilots and intelligent machines. Specifically, it develops an analogy between load balancing using distributed non-homogeneous multiprocessors and human team functions. A taxonomy is presented which can be used to identify task combinations likely to cause overload for dynamic scheduling and process allocation mechanisms. Designer criteria are given for function decomposition, separation of control from data, and communication handling for dynamic tasks. Possible effects of n-p complete scheduling problems are noted and a class of combinatorial optimization methods are examined.

Application of computational aeroacoustic methodologies to advanced propeller configurations - A review

NASA Technical Reports Server (NTRS)

Korkan, Kenneth D.; Eagleson, Lisa A.; Griffiths, Robert C.

1991-01-01

Current research in the area of advanced propeller configurations for performance and acoustics are briefly reviewed. Particular attention is given to the techniques of Lock and Theodorsen modified for use in the design of counterrotating propeller configurations; a numerical method known as SSTAGE, which is a Euler solver for the unducted fan concept; the NASPROP-E numerical analysis also based on a Euler solver and used to study the near acoustic fields for the SR series propfan configurations; and a counterrotating propeller test rig designed to obtain an experimental performance/acoustic data base for various propeller configurations.

Composite structural materials

NASA Technical Reports Server (NTRS)

Ansell, G. S.; Loewy, R. G.; Wiberley, S. E.

1979-01-01

A multifaceted program is described in which aeronautical, mechanical, and materials engineers interact to develop composite aircraft structures. Topics covered include: (1) the design of an advanced composite elevator and a proposed spar and rib assembly; (2) optimizing fiber orientation in the vicinity of heavily loaded joints; (3) failure mechanisms and delamination; (4) the construction of an ultralight sailplane; (5) computer-aided design; finite element analysis programs, preprocessor development, and array preprocessor for SPAR; (6) advanced analysis methods for composite structures; (7) ultrasonic nondestructive testing; (8) physical properties of epoxy resins and composites; (9) fatigue in composite materials, and (10) transverse thermal expansion of carbon/epoxy composites.

Exploration of Advanced Probabilistic and Stochastic Design Methods

NASA Technical Reports Server (NTRS)

Mavris, Dimitri N.

2003-01-01

The primary objective of the three year research effort was to explore advanced, non-deterministic aerospace system design methods that may have relevance to designers and analysts. The research pursued emerging areas in design methodology and leverage current fundamental research in the area of design decision-making, probabilistic modeling, and optimization. The specific focus of the three year investigation was oriented toward methods to identify and analyze emerging aircraft technologies in a consistent and complete manner, and to explore means to make optimal decisions based on this knowledge in a probabilistic environment. The research efforts were classified into two main areas. First, Task A of the grant has had the objective of conducting research into the relative merits of possible approaches that account for both multiple criteria and uncertainty in design decision-making. In particular, in the final year of research, the focus was on the comparison and contrasting between three methods researched. Specifically, these three are the Joint Probabilistic Decision-Making (JPDM) technique, Physical Programming, and Dempster-Shafer (D-S) theory. The next element of the research, as contained in Task B, was focused upon exploration of the Technology Identification, Evaluation, and Selection (TIES) methodology developed at ASDL, especially with regards to identification of research needs in the baseline method through implementation exercises. The end result of Task B was the documentation of the evolution of the method with time and a technology transfer to the sponsor regarding the method, such that an initial capability for execution could be obtained by the sponsor. Specifically, the results of year 3 efforts were the creation of a detailed tutorial for implementing the TIES method. Within the tutorial package, templates and detailed examples were created for learning and understanding the details of each step. For both research tasks, sample files and tutorials are attached in electronic form with the enclosed CD.

System Design Techniques for Reducing the Power Requirements of Advanced life Support Systems

NASA Technical Reports Server (NTRS)

Finn, Cory; Levri, Julie; Pawlowski, Chris; Crawford, Sekou; Luna, Bernadette (Technical Monitor)

2000-01-01

The high power requirement associated with overall operation of regenerative life support systems is a critical Z:p technological challenge. Optimization of individual processors alone will not be sufficient to produce an optimized system. System studies must be used in order to improve the overall efficiency of life support systems. Current research efforts at NASA Ames Research Center are aimed at developing approaches for reducing system power and energy usage in advanced life support systems. System energy integration and energy reuse techniques are being applied to advanced life support, in addition to advanced control methods for efficient distribution of power and thermal resources. An overview of current results of this work will be presented. The development of integrated system designs that reuse waste heat from sources such as crop lighting and solid waste processing systems will reduce overall power and cooling requirements. Using an energy integration technique known as Pinch analysis, system heat exchange designs are being developed that match hot and cold streams according to specific design principles. For various designs, the potential savings for power, heating and cooling are being identified and quantified. The use of state-of-the-art control methods for distribution of resources, such as system cooling water or electrical power, will also reduce overall power and cooling requirements. Control algorithms are being developed which dynamically adjust the use of system resources by the various subsystems and components in order to achieve an overall goal, such as smoothing of power usage and/or heat rejection profiles, while maintaining adequate reserves of food, water, oxygen, and other consumables, and preventing excessive build-up of waste materials. Reductions in the peak loading of the power and thermal systems will lead to lower overall requirements. Computer simulation models are being used to test various control system designs.

Structural analysis at aircraft conceptual design stage

NASA Astrophysics Data System (ADS)

Mansouri, Reza

In the past 50 years, computers have helped by augmenting human efforts with tremendous pace. The aircraft industry is not an exception. Aircraft industry is more than ever dependent on computing because of a high level of complexity and the increasing need for excellence to survive a highly competitive marketplace. Designers choose computers to perform almost every analysis task. But while doing so, existing effective, accurate and easy to use classical analytical methods are often forgotten, which can be very useful especially in the early phases of the aircraft design where concept generation and evaluation demands physical visibility of design parameters to make decisions [39, 2004]. Structural analysis methods have been used by human beings since the very early civilization. Centuries before computers were invented; the pyramids were designed and constructed by Egyptians around 2000 B.C, the Parthenon was built by the Greeks, around 240 B.C, Dujiangyan was built by the Chinese. Persepolis, Hagia Sophia, Taj Mahal, Eiffel tower are only few more examples of historical buildings, bridges and monuments that were constructed before we had any advancement made in computer aided engineering. Aircraft industry is no exception either. In the first half of the 20th century, engineers used classical method and designed civil transport aircraft such as Ford Tri Motor (1926), Lockheed Vega (1927), Lockheed 9 Orion (1931), Douglas DC-3 (1935), Douglas DC-4/C-54 Skymaster (1938), Boeing 307 (1938) and Boeing 314 Clipper (1939) and managed to become airborne without difficulty. Evidencing, while advanced numerical methods such as the finite element analysis is one of the most effective structural analysis methods; classical structural analysis methods can also be as useful especially during the early phase of a fixed wing aircraft design where major decisions are made and concept generation and evaluation demands physical visibility of design parameters to make decisions. Considering the strength and limitations of both methodologies, the question to be answered in this thesis is: How valuable and compatible are the classical analytical methods in today's conceptual design environment? And can these methods complement each other? To answer these questions, this thesis investigates the pros and cons of classical analytical structural analysis methods during the conceptual design stage through the following objectives: Illustrate structural design methodology of these methods within the framework of Aerospace Vehicle Design (AVD) lab's design lifecycle. Demonstrate the effectiveness of moment distribution method through four case studies. This will be done by considering and evaluating the strength and limitation of these methods. In order to objectively quantify the limitation and capabilities of the analytical method at the conceptual design stage, each case study becomes more complex than the one before.

Advanced Technology Composite Fuselage - Repair and Damage Assessment Supporting Maintenance

NASA Technical Reports Server (NTRS)

Flynn, B. W.; Bodine, J. B.; Dopker, B.; Finn, S. R.; Griess, K. H.; Hanson, C. T.; Harris, C. G.; Nelson, K. M.; Walker, T. H.; Kennedy, T. C.;

Electromagnetic Compatibility in the Defense Systems of Future Years

DTIC Science & Technology

2002-06-01

Technology activities. Its mission is to conduct and promote cooperative research and information exchange . The objective is to support the development...testing CLEARANCE PRODUCTION AND IN-SERVICE SUPPORT Modelling in support of conceptual design (structure & installation design) EMH Design guides for the... marketed by Advanced Electromagnetics [6-1]. Transmission Line Matrix Method The link between field theory and circuit theory, the major theories on

Advancing Virtual Patient Simulations through Design Research and InterPLAY: Part I--Design and Development

ERIC Educational Resources Information Center

Hirumi, Atsusi; Kleinsmith, Andrea; Johnsen, Kyle; Kubovec, Stacey; Eakins, Michael; Bogert, Kenneth; Rivera-Gutierrez, Diego J.; Reyes, Ramsamooj Javier; Lok, Benjamin; Cendan, Juan

2016-01-01

Systematic reviews and meta-analyses of randomized controlled studies conclude that virtual patient simulations are consistently associated with higher learning outcomes compared to other educational methods. However, we cannot assume that students will learn from simply exposing students to the simulations. The instructional features that are…

Molecular Docking of Enzyme Inhibitors: A Computational Tool for Structure-Based Drug Design

ERIC Educational Resources Information Center

Rudnitskaya, Aleksandra; Torok, Bela; Torok, Marianna

2010-01-01

Molecular docking is a frequently used method in structure-based rational drug design. It is used for evaluating the complex formation of small ligands with large biomolecules, predicting the strength of the bonding forces and finding the best geometrical arrangements. The major goal of this advanced undergraduate biochemistry laboratory exercise…

An application of holographic interferometry for dynamic vibration analysis of a jet engine turbine compressor rotor

NASA Astrophysics Data System (ADS)

Fein, Howard

2003-09-01

Holographic Interferometry has been successfully employed to characterize the materials and behavior of diverse types of structures under dynamic stress. Specialized variations of this technology have also been applied to define dynamic and vibration related structural behavior. Such applications of holographic technique offer some of the most effective methods of modal and dynamic analysis available. Real-time dynamic testing of the modal and mechanical behavior of jet engine turbine, rotor, vane, and compressor structures has always required advanced instrumentation for data collection in either simulated flight operation test or computer-based modeling and simulations. Advanced optical holography techniques are alternate methods which result in actual full-field behavioral data in a noninvasive, noncontact environment. These methods offer significant insight in both the development and subsequent operational test and modeling of advanced jet engine turbine and compressor rotor structures and their integration with total vehicle system dynamics. Structures and materials can be analyzed with very low amplitude excitation and the resultant data can be used to adjust the accuracy of mathematically derived structural and behavioral models. Holographic Interferometry offers a powerful tool to aid in the developmental engineering of turbine rotor and compressor structures for high stress applications. Aircraft engine applications in particular most consider operational environments where extremes in vibration and impulsive as well as continuous mechanical stress can affect both operation and structural stability. These considerations present ideal requisites for analysis using advanced holographic methods in the initial design and test of turbine rotor components. Holographic techniques are nondestructive, real-time, and definitive in allowing the identification of vibrational modes, displacements, and motion geometries. Such information can be crucial to the determination of mechanical configurations and designs as well as critical operational parameters of turbine structural components or unit turbine components fabricated from advanced and exotic new materials or using new fabrication methods. Anomalous behavioral characteristics can be directly related to hidden structural or mounting anomalies and defects.

MECHANISTIC INDICATORS OF CHILDHOOD ASTHMA (MICA): A SYSTEMS BIOLOGY APPROACH FOR THE INTEGRATION OF MULTIFACTORIAL EXPOSURE AND ENVIRONMENTAL HEALTH DATA

EPA Science Inventory

Modem methods in molecular biology and advanced computational tools show promise in elucidating complex interactions that occur between genes and environmental factors in diseases such as asthma. However, appropriately designed studies are critical for these methods to reach the...

Advanced Methods in Distance Education: Applications and Practices for Educators, Administrators and Learners

ERIC Educational Resources Information Center

Dooley, Kim E.; Lindner, James R.; Dooley, Larry M.

2005-01-01

Courses and programs being delivered at a distance require a unique set of professional competencies. Whether using synchronous or asynchronous methods of instruction, systematic instructional design can help stimulate motivation, increase interaction and social presence, and authenticate learning outcomes. Principles of adult learning, including…

Origins, Methods and Advances in Qualitative Meta-Synthesis

ERIC Educational Resources Information Center

Nye, Elizabeth; Melendez-Torres, G. J.; Bonell, Chris

2016-01-01

Qualitative research is a broad term encompassing many methods. Critiques of the field of qualitative research argue that while individual studies provide rich descriptions and insights, the absence of connections drawn between studies limits their usefulness. In response, qualitative meta-synthesis serves as a design to interpret and synthesise…

Tools and Methods for Teaching Informatics at School: An Advanced Logo Course.

ERIC Educational Resources Information Center

Nikolov, Rumen

1992-01-01

Describes a course in educational informatics for preservice teachers and students in educational software development that emphasizes the use of LOGO, and summarizes course modules that cover tools and methods for teaching informatics, informatics curriculum design, introducing the basic notions of informatics, integrating informatics into the…

Helicopter rotor and engine sizing for preliminary performance estimation

NASA Technical Reports Server (NTRS)

Talbot, P. D.; Bowles, J. V.; Lee, H. C.

1986-01-01

Methods are presented for estimating some of the more fundamental design variables of single-rotor helicopters (tip speed, blade area, disk loading, and installed power) based on design requirements (speed, weight, fuselage drag, and design hover ceiling). The well-known constraints of advancing-blade compressibility and retreating-blade stall are incorporated into the estimation process, based on an empirical interpretation of rotor performance data from large-scale wind-tunnel tests. Engine performance data are presented and correlated with a simple model usable for preliminary design. When approximate results are required quickly, these methods may be more convenient to use and provide more insight than large digital computer programs.

Integration of design and inspection

NASA Astrophysics Data System (ADS)

Simmonds, William H.

1990-08-01

Developments in advanced computer integrated manufacturing technology, coupled with the emphasis on Total Quality Management, are exposing needs for new techniques to integrate all functions from design through to support of the delivered product. One critical functional area that must be integrated into design is that embracing the measurement, inspection and test activities necessary for validation of the delivered product. This area is being tackled by a collaborative project supported by the UK Government Department of Trade and Industry. The project is aimed at developing techniques for analysing validation needs and for planning validation methods. Within the project an experimental Computer Aided Validation Expert system (CAVE) is being constructed. This operates with a generalised model of the validation process and helps with all design stages: specification of product requirements; analysis of the assurance provided by a proposed design and method of manufacture; development of the inspection and test strategy; and analysis of feedback data. The kernel of the system is a knowledge base containing knowledge of the manufacturing process capabilities and of the available inspection and test facilities. The CAVE system is being integrated into a real life advanced computer integrated manufacturing facility for demonstration and evaluation.

Recent advances in computational methodology for simulation of mechanical circulatory assist devices

PubMed Central

Marsden, Alison L.; Bazilevs, Yuri; Long, Christopher C.; Behr, Marek

2014-01-01

Ventricular assist devices (VADs) provide mechanical circulatory support to offload the work of one or both ventricles during heart failure. They are used in the clinical setting as destination therapy, as bridge to transplant, or more recently as bridge to recovery to allow for myocardial remodeling. Recent developments in computational simulation allow for detailed assessment of VAD hemodynamics for device design and optimization for both children and adults. Here, we provide a focused review of the recent literature on finite element methods and optimization for VAD simulations. As VAD designs typically fall into two categories, pulsatile and continuous flow devices, we separately address computational challenges of both types of designs, and the interaction with the circulatory system with three representative case studies. In particular, we focus on recent advancements in finite element methodology that has increased the fidelity of VAD simulations. We outline key challenges, which extend to the incorporation of biological response such as thrombosis and hemolysis, as well as shape optimization methods and challenges in computational methodology. PMID:24449607

Design of a magnetic shielding system for the time of flight enhanced diagnostics neutron spectrometer at Experimental Advanced Superconducting Tokamak

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cui, Z. Q.; Chen, Z. J.; Xie, X. F.

2014-11-15

The novel neutron spectrometer TOFED (Time of Flight Enhanced Diagnostics), comprising 90 individual photomultiplier tubes coupled with 85 plastic scintillation detectors through light guides, has been constructed and installed at Experimental Advanced Superconducting Tokamak. A dedicated magnetic shielding system has been constructed for TOFED, and is designed to guarantee the normal operation of photomultiplier tubes in the stray magnetic field leaking from the tokamak device. Experimental measurements and numerical simulations carried out employing the finite element method are combined to optimize the design of the magnetic shielding system. The system allows detectors to work properly in an external magnetic fieldmore » of 200 G.« less

Optimal design application on the advanced aeroelastic rotor blade

NASA Technical Reports Server (NTRS)

Wei, F. S.; Jones, R.

1985-01-01

The vibration and performance optimization procedure using regression analysis was successfully applied to an advanced aeroelastic blade design study. The major advantage of this regression technique is that multiple optimizations can be performed to evaluate the effects of various objective functions and constraint functions. The data bases obtained from the rotorcraft flight simulation program C81 and Myklestad mode shape program are analytically determined as a function of each design variable. This approach has been verified for various blade radial ballast weight locations and blade planforms. This method can also be utilized to ascertain the effect of a particular cost function which is composed of several objective functions with different weighting factors for various mission requirements without any additional effort.

The Advanced Glaucoma Intervention Study (AGIS): 1. Study design and methods and baseline characteristics of study patients.

PubMed

Ederer, F; Gaasterland, D E; Sullivan, E K

1994-08-01

Medical therapy has been the standard initial treatment for open-angle glaucoma. When some visual field has been lost and maximum tolerated and effective medical therapy does not succeed in controlling the disease, the patient is considered to have advanced glaucoma, and the first of a potential sequence of surgical treatments is usually indicated. Little is known about the long-term course and prognosis of advanced glaucoma or about the long-term effectiveness of sequential surgical treatments in controlling the disease and preventing vision loss and blindness. The Advanced Glaucoma Intervention Study was designed to study, in advanced glaucoma, the long-term clinical course and prognosis, and, in a randomized trial, the comparative outcomes of two sequences of surgical treatments. Toward these goals, 789 eyes in 591 patients were enrolled at 11 clinical centers between 1988 and 1992. Follow-up will continue until 1996. Eyes were randomly assigned to one of two sequences of surgical treatments. One sequence begins with argon laser trabeculoplasty (ALT), is followed by trabeculectomy, an incisional surgical filtering procedure, should ALT fail to control the disease, and by a second trabeculectomy should the first trabeculectomy fail. The other sequence begins with trabeculectomy, is followed by ALT should the trabeculectomy fail, and by a second trabeculectomy should ALT fail. The main outcome of interest is visual function (visual field and visual acuity). Other important outcomes are intraocular pressure, complications of surgery, time to treatment failure, and extent of need for additional medical therapy. We present in this paper the rationale, objectives, design and methods of the study, and the baseline characteristics of study patients and eyes.

Evaluation of a metal shear web selectively reinforced with filamentary composites for space shuttle application. Phase 3 Summary report: Shear web component testing and analysis

NASA Technical Reports Server (NTRS)

Laakso, J. H.; Straayer, J. W.

1973-01-01

Three large scale advanced composite shear web components were tested and analyzed to evaluate application of the design concept to a space shuttle orbiter thrust structure. The shear web design concept consisted of a titanium-clad + or - 45 deg boron/epoxy web laminate stiffened with vertical boron/epoxy reinforced aluminum stiffeners. The design concept was evaluated to be efficient and practical for the application that was studied. Because of the effects of buckling deflections, a requirement is identified for shear buckling resistant design to maximize the efficiency of highly-loaded advanced composite shear webs. An approximate analysis of prebuckling deflections is presented and computer-aided design results, which consider prebuckling deformations, indicate that the design concept offers a theoretical weight saving of 31 percent relative to all metal construction. Recommendations are made for design concept options and analytical methods that are appropriate for production hardware.

Stitch overlap via coloring technique enables maskless via

NASA Astrophysics Data System (ADS)

Civay, D.; Laffosse, E.

2017-03-01

Lithographic patterning limits can be a cost-barrier that delays advancement to new nodes. This paper introduces a cost-saving design method that enables a maskless via. Multi-patterning or coloring of a design is a technique that is used at advanced nodes to aid in patterning. Coloring allows designers to designate different patterns on one level to be printed with different masks. Stitch overlap via (SOV) is a coloring technique introduced herein. SOV utilizes via-aware coloring and a unique process flow to print a maskless via. Identification of qualifying design structures is achieved through a custom program. The program inputs the design level of the multipatterned layer and the via levels above and below to determine the coloring decomposition. Vias are a particularly challenging layer to print due to the dimensions required for these pillars. SOV is a methodology for identifying qualifying multi-patterned layouts and replacing them with a new design that enables a maskless via layer.

Waveguide design, modeling, and optimization: from photonic nanodevices to integrated photonic circuits

NASA Astrophysics Data System (ADS)

Bordovsky, Michal; Catrysse, Peter; Dods, Steven; Freitas, Marcio; Klein, Jackson; Kotacka, Libor; Tzolov, Velko; Uzunov, Ivan M.; Zhang, Jiazong

2004-05-01

We present the state of the art for commercial design and simulation software in the 'front end' of photonic circuit design. One recent advance is to extend the flexibility of the software by using more than one numerical technique on the same optical circuit. There are a number of popular and proven techniques for analysis of photonic devices. Examples of these techniques include the Beam Propagation Method (BPM), the Coupled Mode Theory (CMT), and the Finite Difference Time Domain (FDTD) method. For larger photonic circuits, it may not be practical to analyze the whole circuit by any one of these methods alone, but often some smaller part of the circuit lends itself to at least one of these standard techniques. Later the whole problem can be analyzed on a unified platform. This kind of approach can enable analysis for cases that would otherwise be cumbersome, or even impossible. We demonstrate solutions for more complex structures ranging from the sub-component layout, through the entire device characterization, to the mask layout and its editing. We also present recent advances in the above well established techniques. This includes the analysis of nano-particles, metals, and non-linear materials by FDTD, photonic crystal design and analysis, and improved models for high concentration Er/Yb co-doped glass waveguide amplifiers.

A method to select human-system interfaces for nuclear power plants

DOE PAGES

Hugo, Jacques Victor; Gertman, David Ira

2015-10-19

The new generation of nuclear power plants (NPPs) will likely make use of state-of-the-art technologies in many areas of the plant. The analysis, design, and selection of advanced human–system interfaces (HSIs) constitute an important part of power plant engineering. Designers need to consider the new capabilities afforded by these technologies in the context of current regulations and new operational concepts, which is why they need a more rigorous method by which to plan the introduction of advanced HSIs in NPP work areas. Much of current human factors research stops at the user interface and fails to provide a definitive processmore » for integration of end user devices with instrumentation and control (I&C) and operational concepts. The current lack of a clear definition of HSI technology, including the process for integration, makes characterization and implementation of new and advanced HSIs difficult. This paper describes how new design concepts in the nuclear industry can be analyzed and how HSI technologies associated with new industrial processes might be considered. Furthermore, it also describes a basis for an understanding of human as well as technology characteristics that could be incorporated into a prioritization scheme for technology selection and deployment plans.« less

Successful applications of computer aided drug discovery: moving drugs from concept to the clinic.

PubMed

Talele, Tanaji T; Khedkar, Santosh A; Rigby, Alan C

2010-01-01

Drug discovery and development is an interdisciplinary, expensive and time-consuming process. Scientific advancements during the past two decades have changed the way pharmaceutical research generate novel bioactive molecules. Advances in computational techniques and in parallel hardware support have enabled in silico methods, and in particular structure-based drug design method, to speed up new target selection through the identification of hits to the optimization of lead compounds in the drug discovery process. This review is focused on the clinical status of experimental drugs that were discovered and/or optimized using computer-aided drug design. We have provided a historical account detailing the development of 12 small molecules (Captopril, Dorzolamide, Saquinavir, Zanamivir, Oseltamivir, Aliskiren, Boceprevir, Nolatrexed, TMI-005, LY-517717, Rupintrivir and NVP-AUY922) that are in clinical trial or have become approved for therapeutic use.

Real-time 2D spatially selective MRI experiments: Comparative analysis of optimal control design methods.

PubMed

Maximov, Ivan I; Vinding, Mads S; Tse, Desmond H Y; Nielsen, Niels Chr; Shah, N Jon

2015-05-01

There is an increasing need for development of advanced radio-frequency (RF) pulse techniques in modern magnetic resonance imaging (MRI) systems driven by recent advancements in ultra-high magnetic field systems, new parallel transmit/receive coil designs, and accessible powerful computational facilities. 2D spatially selective RF pulses are an example of advanced pulses that have many applications of clinical relevance, e.g., reduced field of view imaging, and MR spectroscopy. The 2D spatially selective RF pulses are mostly generated and optimised with numerical methods that can handle vast controls and multiple constraints. With this study we aim at demonstrating that numerical, optimal control (OC) algorithms are efficient for the design of 2D spatially selective MRI experiments, when robustness towards e.g. field inhomogeneity is in focus. We have chosen three popular OC algorithms; two which are gradient-based, concurrent methods using first- and second-order derivatives, respectively; and a third that belongs to the sequential, monotonically convergent family. We used two experimental models: a water phantom, and an in vivo human head. Taking into consideration the challenging experimental setup, our analysis suggests the use of the sequential, monotonic approach and the second-order gradient-based approach as computational speed, experimental robustness, and image quality is key. All algorithms used in this work were implemented in the MATLAB environment and are freely available to the MRI community. Copyright © 2015 Elsevier Inc. All rights reserved.

Intelligent Engine Systems: Thermal Management and Advanced Cooling

NASA Technical Reports Server (NTRS)

Bergholz, Robert

2008-01-01

The objective is to provide turbine-cooling technologies to meet Propulsion 21 goals related to engine fuel burn, emissions, safety, and reliability. Specifically, the GE Aviation (GEA) Advanced Turbine Cooling and Thermal Management program seeks to develop advanced cooling and flow distribution methods for HP turbines, while achieving a substantial reduction in total cooling flow and assuring acceptable turbine component safety and reliability. Enhanced cooling techniques, such as fluidic devices, controlled-vortex cooling, and directed impingement jets, offer the opportunity to incorporate both active and passive schemes. Coolant heat transfer enhancement also can be achieved from advanced designs that incorporate multi-disciplinary optimization of external film and internal cooling passage geometry.

A generalized sizing method for revolutionary concepts under probabilistic design constraints

NASA Astrophysics Data System (ADS)

Nam, Taewoo

Internal combustion (IC) engines that consume hydrocarbon fuels have dominated the propulsion systems of air-vehicles for the first century of aviation. In recent years, however, growing concern over rapid climate changes and national energy security has galvanized the aerospace community into delving into new alternatives that could challenge the dominance of the IC engine. Nevertheless, traditional aircraft sizing methods have significant shortcomings for the design of such unconventionally powered aircraft. First, the methods are specialized for aircraft powered by IC engines, and thus are not flexible enough to assess revolutionary propulsion concepts that produce propulsive thrust through a completely different energy conversion process. Another deficiency associated with the traditional methods is that a user of these methods must rely heavily on experts' experience and advice for determining appropriate design margins. However, the introduction of revolutionary propulsion systems and energy sources is very likely to entail an unconventional aircraft configuration, which inexorably disqualifies the conjecture of such "connoisseurs" as a means of risk management. Motivated by such deficiencies, this dissertation aims at advancing two aspects of aircraft sizing: (1) to develop a generalized aircraft sizing formulation applicable to a wide range of unconventionally powered aircraft concepts and (2) to formulate a probabilistic optimization technique that is able to quantify appropriate design margins that are tailored towards the level of risk deemed acceptable to a decision maker. A more generalized aircraft sizing formulation, named the Architecture Independent Aircraft Sizing Method (AIASM), was developed for sizing revolutionary aircraft powered by alternative energy sources by modifying several assumptions of the traditional aircraft sizing method. Along with advances in deterministic aircraft sizing, a non-deterministic sizing technique, named the Probabilistic Aircraft Sizing Method (PASM), was developed. The method allows one to quantify adequate design margins to account for the various sources of uncertainty via the application of the chance-constrained programming (CCP) strategy to AIASM. In this way, PASM can also provide insights into a good compromise between cost and safety.

Biological materials by design.

PubMed

Qin, Zhao; Dimas, Leon; Adler, David; Bratzel, Graham; Buehler, Markus J

2014-02-19

In this topical review we discuss recent advances in the use of physical insight into the way biological materials function, to design novel engineered materials 'from scratch', or from the level of fundamental building blocks upwards and by using computational multiscale methods that link chemistry to material function. We present studies that connect advances in multiscale hierarchical material structuring with material synthesis and testing, review case studies of wood and other biological materials, and illustrate how engineered fiber composites and bulk materials are designed, modeled, and then synthesized and tested experimentally. The integration of experiment and simulation in multiscale design opens new avenues to explore the physics of materials from a fundamental perspective, and using complementary strengths from models and empirical techniques. Recent developments in this field illustrate a new paradigm by which complex material functionality is achieved through hierarchical structuring in spite of simple material constituents.

Sealing in Turbomachinery

NASA Technical Reports Server (NTRS)

Chupp, Raymond E.; Hendricks, Robert C.; Lattime, Scott B.; Steinetz, Bruce M.

2006-01-01

Clearance control is of paramount importance to turbomachinery designers and is required to meet today's aggressive power output, efficiency, and operational life goals. Excessive clearances lead to losses in cycle efficiency, flow instabilities, and hot gas ingestion into disk cavities. Insufficient clearances limit coolant flows and cause interface rubbing, overheating downstream components and damaging interfaces, thus limiting component life. Designers have put renewed attention on clearance control, as it is often the most cost effective method to enhance system performance. Advanced concepts and proper material selection continue to play important roles in maintaining interface clearances to enable the system to meet design goals. This work presents an overview of turbomachinery sealing to control clearances. Areas covered include: characteristics of gas and steam turbine sealing applications and environments, benefits of sealing, types of standard static and dynamics seals, advanced seal designs, as well as life and limitations issues.

A Proposal for the use of the Consortium Method in the Design-build system

NASA Astrophysics Data System (ADS)

Miyatake, Ichiro; Kudo, Masataka; Kawamata, Hiroyuki; Fueta, Toshiharu

In view of the necessity for efficient implementation of public works projects, it is expected to utilize advanced technical skills of private firms, for the purpose of reducing project costs, improving performance and functions of construction objects, and reducing work periods, etc. The design-build system is a method to order design and construction as a single contract, including design of structural forms and main specifications of the construction object. This is a system in which high techniques of private firms can be utilized, as a means to ensure qualities of design and construction, rational design, and efficiency of the project. The objective of this study is to examine the use of a method to form a consortium of civil engineering consultants and construction companies, as it is an issue related to the implementation of the design-build method. Furthermore, by studying various forms of consortiums to be introduced in future, it proposes procedural items required to utilize this method, during the bid and after signing a contract, such as the estimate submission from the civil engineering consultants etc.

The application of virtual prototyping methods to determine the dynamic parameters of mobile robot

NASA Astrophysics Data System (ADS)

Kurc, Krzysztof; Szybicki, Dariusz; Burghardt, Andrzej; Muszyńska, Magdalena

2016-04-01

The paper presents methods used to determine the parameters necessary to build a mathematical model of an underwater robot with a crawler drive. The parameters present in the dynamics equation will be determined by means of advanced mechatronic design tools, including: CAD/CAE software andMES modules. The virtual prototyping process is described as well as the various possible uses (design adaptability) depending on the optional accessories added to the vehicle. A mathematical model is presented to show the kinematics and dynamics of the underwater crawler robot, essential for the design stage.

A Meta-Analysis Method to Advance Design of Technology-Based Learning Tool: Combining Qualitative and Quantitative Research to Understand Learning in Relation to Different Technology Features

ERIC Educational Resources Information Center

Zhang, Lin

2014-01-01

Educators design and create various technology tools to scaffold students' learning. As more and more technology designs are incorporated into learning, growing attention has been paid to the study of technology-based learning tool. This paper discusses the emerging issues, such as how can learning effectiveness be understood in relation to…

CFD-based optimization in plastics extrusion

NASA Astrophysics Data System (ADS)

Eusterholz, Sebastian; Elgeti, Stefanie

2018-05-01

This paper presents novel ideas in numerical design of mixing elements in single-screw extruders. The actual design process is reformulated as a shape optimization problem, given some functional, but possibly inefficient initial design. Thereby automatic optimization can be incorporated and the design process is advanced, beyond the simulation-supported, but still experience-based approach. This paper proposes concepts to extend a method which has been developed and validated for die design to the design of mixing-elements. For simplicity, it focuses on single-phase flows only. The developed method conducts forward-simulations to predict the quasi-steady melt behavior in the relevant part of the extruder. The result of each simulation is used in a black-box optimization procedure based on an efficient low-order parameterization of the geometry. To minimize user interaction, an objective function is formulated that quantifies the products' quality based on the forward simulation. This paper covers two aspects: (1) It reviews the set-up of the optimization framework as discussed in [1], and (2) it details the necessary extensions for the optimization of mixing elements in single-screw extruders. It concludes with a presentation of first advances in the unsteady flow simulation of a metering and mixing section with the SSMUM [2] using the Carreau material model.

Rotorcraft Brownout: Advanced Understanding, Control and Mitigation

DTIC Science & Technology

2008-12-31

the Gauss Seidel iterative method . The overall steps of SIMPLER algorithm can be summarized as: 1. Guess velocity field, 2. Calculate the momentum...techniques and numerical methods , and the team will begin to develop a methodology that is capable of integrating these solutions and highlighting...rotorcraft design optimization techniques will then be undertaken using the validated computational methods . 15. SUBJECT TERMS Rotorcraft

Advanced scatter search approach and its application in a sequencing problem of mixed-model assembly lines in a case company

NASA Astrophysics Data System (ADS)

Liu, Qiong; Wang, Wen-xi; Zhu, Ke-ren; Zhang, Chao-yong; Rao, Yun-qing

2014-11-01

Mixed-model assembly line sequencing is significant in reducing the production time and overall cost of production. To improve production efficiency, a mathematical model aiming simultaneously to minimize overtime, idle time and total set-up costs is developed. To obtain high-quality and stable solutions, an advanced scatter search approach is proposed. In the proposed algorithm, a new diversification generation method based on a genetic algorithm is presented to generate a set of potentially diverse and high-quality initial solutions. Many methods, including reference set update, subset generation, solution combination and improvement methods, are designed to maintain the diversification of populations and to obtain high-quality ideal solutions. The proposed model and algorithm are applied and validated in a case company. The results indicate that the proposed advanced scatter search approach is significant for mixed-model assembly line sequencing in this company.

[Research advances in secondary development of Chinese patent medicines based on quality by design concept].

PubMed

Gong, Xing-Chu; Chen, Teng; Qu, Hai-Bin

2017-03-01

Quality by design (QbD) concept is an advanced pharmaceutical quality control concept. The application of QbD concept in the research and development of pharmaceutical processes of traditional Chinese medicines (TCM) mainly contains five parts, including the definition of critical processes and their evaluation criteria, the determination of critical process parameters and critical material attributes, the establishment of quantitative models, the development of design space, as well as the application and continuous improvement of control strategy. In this work, recent research advances in QbD concept implementation methods in the secondary development of Chinese patent medicines were reviewed, and five promising fields of the implementation of QbD concept were pointed out, including the research and development of TCM new drugs and Chinese medicine granules for formulation, modeling of pharmaceutical processes, development of control strategy based on industrial big data, strengthening the research of process amplification rules, and the development of new pharmaceutical equipment.. Copyright© by the Chinese Pharmaceutical Association.

Computational Approaches to Nucleic Acid Origami.

PubMed

Jabbari, Hosna; Aminpour, Maral; Montemagno, Carlo

2015-10-12

Recent advances in experimental DNA origami have dramatically expanded the horizon of DNA nanotechnology. Complex 3D suprastructures have been designed and developed using DNA origami with applications in biomaterial science, nanomedicine, nanorobotics, and molecular computation. Ribonucleic acid (RNA) origami has recently been realized as a new approach. Similar to DNA, RNA molecules can be designed to form complex 3D structures through complementary base pairings. RNA origami structures are, however, more compact and more thermodynamically stable due to RNA's non-canonical base pairing and tertiary interactions. With all these advantages, the development of RNA origami lags behind DNA origami by a large gap. Furthermore, although computational methods have proven to be effective in designing DNA and RNA origami structures and in their evaluation, advances in computational nucleic acid origami is even more limited. In this paper, we review major milestones in experimental and computational DNA and RNA origami and present current challenges in these fields. We believe collaboration between experimental nanotechnologists and computer scientists are critical for advancing these new research paradigms.

Advanced online control mode selection for gas turbine aircraft engines

NASA Astrophysics Data System (ADS)

Wiseman, Matthew William

The modern gas turbine aircraft engine is a complex, highly nonlinear system the operates in a widely varying environment. Traditional engine control techniques based on the hydro mechanical control concepts of early turbojet engines are unable to deliver the performance required from today's advanced engine designs. A new type of advanced control utilizing multiple control modes and an online mode selector is investigated, and various strategies for improving the baseline mode selection architecture are introduced. The ability to five-tune actuator command outputs is added to the basic mode selection and blending process, and mode selection designs that we valid for the entire flight envelope are presented. Methods for optimizing the mode selector to improve overall engine performance are also discussed. Finally, using flight test data from a GE F110-powered F16 aircraft, the full-envelope mode selector designs are validated and shown to provide significant performance benefits. Specifically, thrust command tracking is enhanced while critical engine limits are protected, with very little impact on engine efficiency.

Producibility aspects of advanced composites for an L-1011 Aileron

NASA Technical Reports Server (NTRS)

Van Hamersveld, J.; Fogg, L. D.

1976-01-01

The design of advanced composite aileron suitable for long-term service on transport aircraft includes Kevlar 49 fabric skins on honeycomb sandwich covers, hybrid graphite/Kevlar 49 ribs and spars, and graphite/epoxy fittings. Weight and cost savings of 28 and 20 percent, respectively, are predicted by comparison with the production metallic aileron. The structural integrity of the design has been substantiated by analysis and static tests of subcomponents. The producibility considerations played a key role in the selection of design concepts with potential for low-cost production. Simplicity in fabrication is a major factor in achieving low cost using advanced tooling and manufacturing methods such as net molding to size, draping, forming broadgoods, and cocuring components. A broadgoods dispensing machine capable of handling unidirectional and bidirectional prepreg materials in widths ranging from 12 to 42 inches is used for rapid layup of component kits and covers. Existing large autoclaves, platen presses, and shop facilities are fully exploited.

Preliminary noise tradeoff study of a Mach 2.7 cruise aircraft

NASA Technical Reports Server (NTRS)

Mascitti, V. R.; Maglieri, D. J. (Editor); Raney, J. P. (Editor)

1979-01-01

NASA computer codes in the areas of preliminary sizing and enroute performance, takeoff and landing performance, aircraft noise prediction, and economics were used in a preliminary noise tradeoff study for a Mach 2.7 design supersonic cruise concept. Aerodynamic configuration data were based on wind-tunnel model tests and related analyses. Aircraft structural characteristics and weight were based on advanced structural design methodologies, assuming conventional titanium technology. The most advanced noise prediction techniques available were used, and aircraft operating costs were estimated using accepted industry methods. The 4-engines cycles included in the study were based on assumed 1985 technology levels. Propulsion data was provided by aircraft manufacturers. Additional empirical data is needed to define both noise reduction features and other operating characteristics of all engine cycles under study. Data on VCE design parameters, coannular nozzle inverted flow noise reduction and advanced mechanical suppressors are urgently needed to reduce the present uncertainties in studies of this type.

Dakota, a multilevel parallel object-oriented framework for design optimization, parameter estimation, uncertainty quantification, and sensitivity analysis :

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Brian M.; Ebeida, Mohamed Salah; Eldred, Michael S.

The Dakota (Design Analysis Kit for Optimization and Terascale Applications) toolkit provides a exible and extensible interface between simulation codes and iterative analysis methods. Dakota contains algorithms for optimization with gradient and nongradient-based methods; uncertainty quanti cation with sampling, reliability, and stochastic expansion methods; parameter estimation with nonlinear least squares methods; and sensitivity/variance analysis with design of experiments and parameter study methods. These capabilities may be used on their own or as components within advanced strategies such as surrogate-based optimization, mixed integer nonlinear programming, or optimization under uncertainty. By employing object-oriented design to implement abstractions of the key components requiredmore » for iterative systems analyses, the Dakota toolkit provides a exible and extensible problem-solving environment for design and performance analysis of computational models on high performance computers. This report serves as a user's manual for the Dakota software and provides capability overviews and procedures for software execution, as well as a variety of example studies.« less

Development and Application of Advanced Ophthalmic Imaging Technology to Enhance Military Ocular Health Capabilities

DTIC Science & Technology

2009-04-01

active military personnel and veterans, are affected by three major blinding diseases of the retina and optic nerve: diabetic retinopathy , age-related...disease is detected early. New advanced detection methods are available, but are only interpretable by very experienced specialists. The goal of this...consist of several steps [1-3]: feature detection ; transform model estimation; optimization function design; and optimization strategies. We do not

Cost estimating methods for advanced space systems

NASA Technical Reports Server (NTRS)

Cyr, Kelley

1988-01-01

Parametric cost estimating methods for space systems in the conceptual design phase are developed. The approach is to identify variables that drive cost such as weight, quantity, development culture, design inheritance, and time. The relationship between weight and cost is examined in detail. A theoretical model of cost is developed and tested statistically against a historical data base of major research and development programs. It is concluded that the technique presented is sound, but that it must be refined in order to produce acceptable cost estimates.

Physics-based scoring of protein-ligand interactions: explicit polarizability, quantum mechanics and free energies.

PubMed

Bryce, Richard A

2011-04-01

The ability to accurately predict the interaction of a ligand with its receptor is a key limitation in computer-aided drug design approaches such as virtual screening and de novo design. In this article, we examine current strategies for a physics-based approach to scoring of protein-ligand affinity, as well as outlining recent developments in force fields and quantum chemical techniques. We also consider advances in the development and application of simulation-based free energy methods to study protein-ligand interactions. Fuelled by recent advances in computational algorithms and hardware, there is the opportunity for increased integration of physics-based scoring approaches at earlier stages in computationally guided drug discovery. Specifically, we envisage increased use of implicit solvent models and simulation-based scoring methods as tools for computing the affinities of large virtual ligand libraries. Approaches based on end point simulations and reference potentials allow the application of more advanced potential energy functions to prediction of protein-ligand binding affinities. Comprehensive evaluation of polarizable force fields and quantum mechanical (QM)/molecular mechanical and QM methods in scoring of protein-ligand interactions is required, particularly in their ability to address challenging targets such as metalloproteins and other proteins that make highly polar interactions. Finally, we anticipate increasingly quantitative free energy perturbation and thermodynamic integration methods that are practical for optimization of hits obtained from screened ligand libraries.

Structural Analysis Made 'NESSUSary'

NASA Technical Reports Server (NTRS)

2005-01-01

Everywhere you look, chances are something that was designed and tested by a computer will be in plain view. Computers are now utilized to design and test just about everything imaginable, from automobiles and airplanes to bridges and boats, and elevators and escalators to streets and skyscrapers. Computer-design engineering first emerged in the 1970s, in the automobile and aerospace industries. Since computers were in their infancy, however, architects and engineers during the time were limited to producing only designs similar to hand-drafted drawings. (At the end of 1970s, a typical computer-aided design system was a 16-bit minicomputer with a price tag of $125,000.) Eventually, computers became more affordable and related software became more sophisticated, offering designers the "bells and whistles" to go beyond the limits of basic drafting and rendering, and venture into more skillful applications. One of the major advancements was the ability to test the objects being designed for the probability of failure. This advancement was especially important for the aerospace industry, where complicated and expensive structures are designed. The ability to perform reliability and risk assessment without using extensive hardware testing is critical to design and certification. In 1984, NASA initiated the Probabilistic Structural Analysis Methods (PSAM) project at Glenn Research Center to develop analysis methods and computer programs for the probabilistic structural analysis of select engine components for current Space Shuttle and future space propulsion systems. NASA envisioned that these methods and computational tools would play a critical role in establishing increased system performance and durability, and assist in structural system qualification and certification. Not only was the PSAM project beneficial to aerospace, it paved the way for a commercial risk- probability tool that is evaluating risks in diverse, down- to-Earth application

Full-Scale Turbofan Engine Noise-Source Separation Using a Four-Signal Method

NASA Technical Reports Server (NTRS)

Hultgren, Lennart S.; Arechiga, Rene O.

2016-01-01

Contributions from the combustor to the overall propulsion noise of civilian transport aircraft are starting to become important due to turbofan design trends and expected advances in mitigation of other noise sources. During on-ground, static-engine acoustic tests, combustor noise is generally sub-dominant to other engine noise sources because of the absence of in-flight effects. Consequently, noise-source separation techniques are needed to extract combustor-noise information from the total noise signature in order to further progress. A novel four-signal source-separation method is applied to data from a static, full-scale engine test and compared to previous methods. The new method is, in a sense, a combination of two- and three-signal techniques and represents an attempt to alleviate some of the weaknesses of each of those approaches. This work is supported by the NASA Advanced Air Vehicles Program, Advanced Air Transport Technology Project, Aircraft Noise Reduction Subproject and the NASA Glenn Faculty Fellowship Program.

Development of Advanced Nuclide Separation and Recovery Methods using Ion-Exchanhge Techniques in Nuclear Backend

NASA Astrophysics Data System (ADS)

Miura, Hitoshi

The development of compact separation and recovery methods using selective ion-exchange techniques is very important for the reprocessing and high-level liquid wastes (HLLWs) treatment in the nuclear backend field. The selective nuclide separation techniques are effective for the volume reduction of wastes and the utilization of valuable nuclides, and expected for the construction of advanced nuclear fuel cycle system and the rationalization of waste treatment. In order to accomplish the selective nuclide separation, the design and synthesis of novel adsorbents are essential for the development of compact and precise separation processes. The present paper deals with the preparation of highly functional and selective hybrid microcapsules enclosing nano-adsorbents in the alginate gel polymer matrices by sol-gel methods, their characterization and the clarification of selective adsorption properties by batch and column methods. The selective separation of Cs, Pd and Re in real HLLW was further accomplished by using novel microcapsules, and an advanced nuclide separation system was proposed by the combination of selective processes using microcapsules.

APPLIED REMOTE SENSING

EPA Science Inventory

Remote Sensing is a scientific discipline of non-contact monitoring. It includes a range of technologies that span from aerial photography to advanced spectral imaging and analytical methods. This Session is designed to demonstrate contemporary practical applications of remote se...

High Performance Structures and Materials

Science.gov Websites

advanced simulation and optimization methods that can be used during the early design stages of innovative Development of Simulation Model Validation Framework for RBDO Sponsored by U.S. Army TARDEC Visit Us Contact

Power Analysis for Complex Mediational Designs Using Monte Carlo Methods

ERIC Educational Resources Information Center

Thoemmes, Felix; MacKinnon, David P.; Reiser, Mark R.

2010-01-01

Applied researchers often include mediation effects in applications of advanced methods such as latent variable models and linear growth curve models. Guidance on how to estimate statistical power to detect mediation for these models has not yet been addressed in the literature. We describe a general framework for power analyses for complex…

A Numerical Methods Course Based on B-Learning: Integrated Learning Design and Follow Up

ERIC Educational Resources Information Center

Cepeda, Francisco Javier Delgado

2013-01-01

Information and communication technologies advance continuously, providing a real support for learning processes. Learning technologies address areas which previously have corresponded to face-to-face learning, while mobile resources are having a growing impact on education. Numerical Methods is a discipline and profession based on technology. In…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wurtz, R.; Kaplan, A.

Pulse shape discrimination (PSD) is a variety of statistical classifier. Fully-­realized statistical classifiers rely on a comprehensive set of tools for designing, building, and implementing. PSD advances rely on improvements to the implemented algorithm. PSD advances can be improved by using conventional statistical classifier or machine learning methods. This paper provides the reader with a glossary of classifier-­building elements and their functions in a fully-­designed and operational classifier framework that can be used to discover opportunities for improving PSD classifier projects. This paper recommends reporting the PSD classifier’s receiver operating characteristic (ROC) curve and its behavior at a gamma rejectionmore » rate (GRR) relevant for realistic applications.« less

Creep fatigue life prediction for engine hot section materials (isotropic): Fourth year progress review

NASA Technical Reports Server (NTRS)

Nelson, Richard S.; Schoendorf, John F.

1986-01-01

As gas turbine technology continues to advance, the need for advanced life prediction methods for hot section components is becoming more and more evident. The complex local strain and temperature histories at critical locations must be accurately interpreted to account for the effects of various damage mechanisms (such as fatigue, creep, and oxidation) and their possible interactions. As part of the overall NASA HOST effort, this program is designed to investigate these fundamental damage processes, identify modeling strategies, and develop practical models which can be used to guide the early design and development of new engines and to increase the durability of existing engines.

Industry survey of space system cost benefits from New Ways Of Doing Business

NASA Technical Reports Server (NTRS)

Rosmait, Russell L.

1992-01-01

The cost of designing, building and operating space system hardware has always been expensive. Small quantities of specialty parts escalate engineering design, production and operations cost. Funding cutbacks and shrinking revenues dictate aggressive cost saving programs. NASA's highest priority is providing economical transportation to and from space. Over the past three decades NASA has seen technological advances that provide grater efficiencies in designing, building, and operating of space system hardware. As future programs such as NLS, LUTE and SEI begin, these greater efficiencies and cost savings should be reflected in the cost models. There are several New Ways Of Doing Business (NWODB) which, when fully implemented will reduce space system costs. These philosophies and/or culture changes are integrated in five areas: (1) More Extensive Pre-Phase C/D & E, (2) Multi Year Funding Stability, (3) Improved Quality, Management and Procurement Processes, (4) Advanced Design Methods, and (5) Advanced Production Methods. Following is an overview of NWODB and the Cost Quantification Analysis results using an industry survey, one of the four quantification techniques used in the study. The NWODB Cost Quantification Analysis is a study performed at Marshall Space Flight Center by the Engineering Cost Group, Applied Research Incorporated and Pittsburg State University. This study took place over a period of four months in mid 1992. The purpose of the study was to identify potential NWODB which could lead to improved cost effectiveness within NASA and to quantify potential cost benefits that might accrue if these NWODB were implemented.

Application of Quality by Design Approach to Bioanalysis: Development of a Method for Elvitegravir Quantification in Human Plasma.

PubMed

Baldelli, Sara; Marrubini, Giorgio; Cattaneo, Dario; Clementi, Emilio; Cerea, Matteo

2017-10-01

The application of Quality by Design (QbD) principles in clinical laboratories can help to develop an analytical method through a systematic approach, providing a significant advance over the traditional heuristic and empirical methodology. In this work, we applied for the first time the QbD concept in the development of a method for drug quantification in human plasma using elvitegravir as the test molecule. The goal of the study was to develop a fast and inexpensive quantification method, with precision and accuracy as requested by the European Medicines Agency guidelines on bioanalytical method validation. The method was divided into operative units, and for each unit critical variables affecting the results were identified. A risk analysis was performed to select critical process parameters that should be introduced in the design of experiments (DoEs). Different DoEs were used depending on the phase of advancement of the study. Protein precipitation and high-performance liquid chromatography-tandem mass spectrometry were selected as the techniques to be investigated. For every operative unit (sample preparation, chromatographic conditions, and detector settings), a model based on factors affecting the responses was developed and optimized. The obtained method was validated and clinically applied with success. To the best of our knowledge, this is the first investigation thoroughly addressing the application of QbD to the analysis of a drug in a biological matrix applied in a clinical laboratory. The extensive optimization process generated a robust method compliant with its intended use. The performance of the method is continuously monitored using control charts.

Advanced Engineering Environments: Implications for Aerospace Manufacturing

NASA Technical Reports Server (NTRS)

Thomas, D.

2001-01-01

There are significant challenges facing today's aerospace industry. Global competition, more complex products, geographically-distributed design teams, demands for lower cost, higher reliability and safer vehicles, and the need to incorporate the latest technologies quicker all face the developer of aerospace systems. New information technologies offer promising opportunities to develop advanced engineering environments (AEEs) to meet these challenges. Significant advances in the state-of-the-art of aerospace engineering practice are envisioned in the areas of engineering design and analytical tools, cost and risk tools, collaborative engineering, and high-fidelity simulations early in the development cycle. These advances will enable modeling and simulation of manufacturing methods, which will in turn allow manufacturing considerations to be included much earlier in the system development cycle. Significant cost savings, increased quality, and decreased manufacturing cycle time are expected to result. This paper will give an overview of the NASA's Intelligent Synthesis Environment, the agency initiative to develop an AEE, with a focus on the anticipated benefits in aerospace manufacturing.

Flow Pattern Phenomena in Two-Phase Flow in Microchannels

NASA Astrophysics Data System (ADS)

Keska, Jerry K.; Simon, William E.

2004-02-01

Space transportation systems require high-performance thermal protection and fluid management techniques for systems ranging from cryogenic fluid management devices to primary structures and propulsion systems exposed to extremely high temperatures, as well as for other space systems such as cooling or environment control for advanced space suits and integrated circuits. Although considerable developmental effort is being expended to bring potentially applicable technologies to a readiness level for practical use, new and innovative methods are still needed. One such method is the concept of Advanced Micro Cooling Modules (AMCMs), which are essentially compact two-phase heat exchangers constructed of microchannels and designed to remove large amounts of heat rapidly from critical systems by incorporating phase transition. The development of AMCMs requires fundamental technological advancement in many areas, including: (1) development of measurement methods/systems for flow-pattern measurement/identification for two-phase mixtures in microchannels; (2) development of a phenomenological model for two-phase flow which includes the quantitative measure of flow patterns; and (3) database development for multiphase heat transfer/fluid dynamics flows in microchannels. This paper focuses on the results of experimental research in the phenomena of two-phase flow in microchannels. The work encompasses both an experimental and an analytical approach to incorporating flow patterns for air-water mixtures flowing in a microchannel, which are necessary tools for the optimal design of AMCMs. Specifically, the following topics are addressed: (1) design and construction of a sensitive test system for two-phase flow in microchannels, one which measures ac and dc components of in-situ physical mixture parameters including spatial concentration using concomitant methods; (2) data acquisition and analysis in the amplitude, time, and frequency domains; and (3) analysis of results including evaluation of data acquisition techniques and their validity for application in flow pattern determination.

1983 AFOSR/AFRPL Chemical Rocket Research Meeting, Abstracts and Agenda. Includes: Abstracts on Advanced Diagnostics of Reacting Flow, 28 February - 3 March 1983, Lancaster, California.

DTIC Science & Technology

1983-02-01

blow-off stability and fractional conversion was evaluated for design of an experimental study of these phenomena. The apparatus designed will be...the development of an array of experimental methods and test strategies designed to unravel a complex process that is very difficult to observe directly...this effort of lead field theoretic analysis as a design basis has made that possible. The experimental phase of the effort has three major

Design of Advanced Blading for a High-Speed HP Compressor Using an S1-S2 Flow Calculation System.

DTIC Science & Technology

1990-11-01

Howell multistage compressor speed squared) and pressure ratio for the initial prediction method (7), with an arbitrary increase of design are given in...improved performance of axial compressors with leading designs to be produced with the current SI-S2 edge normal shock waves, system. However, it is...performance of the new (7) Howell A R and Calvert W J, A new stage- design was extremely encouraging, with a peak stacking technique for axial -flow

Propfan experimental data analysis

NASA Technical Reports Server (NTRS)

Vernon, David F.; Page, Gregory S.; Welge, H. Robert

1984-01-01

A data reduction method, which is consistent with the performance prediction methods used for analysis of new aircraft designs, is defined and compared to the method currently used by NASA using data obtained from an Ames Res. Center 11 foot transonic wind tunnel test. Pressure and flow visualization data from the Ames test for both the powered straight underwing nacelle, and an unpowered contoured overwing nacelle installation is used to determine the flow phenomena present for a wind mounted turboprop installation. The test data is compared to analytic methods, showing the analytic methods to be suitable for design and analysis of new configurations. The data analysis indicated that designs with zero interference drag levels are achieveable with proper wind and nacelle tailoring. A new overwing contoured nacelle design and a modification to the wing leading edge extension for the current wind tunnel model design are evaluated. Hardware constraints of the current model parts prevent obtaining any significant performance improvement due to a modified nacelle contouring. A new aspect ratio wing design for an up outboard rotation turboprop installation is defined, and an advanced contoured nacelle is provided.

Creating an advance-care-planning decision aid for high-risk surgery: a qualitative study

PubMed Central

2014-01-01

Background High-risk surgery patients may lose decision-making capacity as a result of surgical complications. Advance care planning prior to surgery may be beneficial, but remains controversial and is hindered by a lack of appropriate decision aids. This study sought to examine stakeholders’ views on the appropriateness of using decision aids, in general, to support advance care planning among high-risk surgery populations and the design of such a decision aid. Methods Key informants were recruited through purposive and snowball sampling. Semi-structured interviews were conducted by phone until data collected reached theoretical saturation. Key informants were asked to discuss their thoughts about advance care planning and interventions to support advance care planning, particularly for this population. Researchers took de-identified notes that were analyzed for emerging concordant, discordant, and recurrent themes using interpretative phenomenological analysis. Results Key informants described the importance of initiating advance care planning preoperatively, despite potential challenges present in surgical settings. In general, decision aids were viewed as an appropriate approach to support advance care planning for this population. A recipe emerged from the data that outlines tools, ingredients, and tips for success that are needed to design an advance care planning decision aid for high-risk surgical settings. Conclusions Stakeholders supported incorporating advance care planning in high-risk surgical settings and endorsed the appropriateness of using decision aids to do so. Findings will inform the next stages of developing the first advance care planning decision aid for high-risk surgery patients. PMID:25067908

Investigation of mechanistic deterioration modeling for bridge design and management.

DOT National Transportation Integrated Search

2017-04-01

The ongoing deterioration of highway bridges in Colorado dictates that an effective method for allocating limited management resources be developed. In order to predict bridge deterioration in advance, mechanistic models that analyze the physical pro...

Applications of Nanoporous Materials in Agriculture

USDA-ARS?s Scientific Manuscript database

Nanoporous materials possess organized pore distributions and increased surface areas. Advances in the systematic design of nanoporous materials enable incorporation of functionality for better sensitivity in detection methods, increased capacity of sorbents, and improved selectivity and yield in ca...

Enabling Rapid Naval Architecture Design Space Exploration

NASA Technical Reports Server (NTRS)

Mueller, Michael A.; Dufresne, Stephane; Balestrini-Robinson, Santiago; Mavris, Dimitri

2011-01-01

Well accepted conceptual ship design tools can be used to explore a design space, but more precise results can be found using detailed models in full-feature computer aided design programs. However, defining a detailed model can be a time intensive task and hence there is an incentive for time sensitive projects to use conceptual design tools to explore the design space. In this project, the combination of advanced aerospace systems design methods and an accepted conceptual design tool facilitates the creation of a tool that enables the user to not only visualize ship geometry but also determine design feasibility and estimate the performance of a design.

Analysis/design of strip reinforced random composites (strip hybrids)

NASA Technical Reports Server (NTRS)

Chamis, C. C.; Sinclair, J. H.

1978-01-01

Advanced analysis methods and composite mechanics were applied to a strip-reinforced random composite square panel with fixed ends to illustrate the use of these methods for the a priori assessment of the composite panel when subjected to complex loading conditions. The panel was assumed to be of E-glass random composite. The strips were assumed to be of three advanced unidirectional composites to cover a range of low, intermediate, and high modulus stiffness. The panels were assumed to be subjected to complex loadings to assess their adequacy as load-carrying members in auto body, aircraft engine nacelle and windmill blade applications. The results show that strip hybrid panels can be several times more structurally efficient than the random composite base materials. Some of the results are presented in graphical form and procedures are described for use of these graphs as guides for preliminary design of strip hybrids.

Launching the dialogue: Safety and innovation as partners for success in advanced manufacturing.

PubMed

Geraci, C L; Tinkle, S S; Brenner, S A; Hodson, L L; Pomeroy-Carter, C A; Neu-Baker, N

2018-06-01

Emerging and novel technologies, materials, and information integrated into increasingly automated and networked manufacturing processes or into traditional manufacturing settings are enhancing the efficiency and productivity of manufacturing. Globally, there is a move toward a new era in manufacturing that is characterized by: (1) the ability to create and deliver more complex designs of products; (2) the creation and use of materials with new properties that meet a design need; (3) the employment of new technologies, such as additive and digital techniques that improve on conventional manufacturing processes; and (4) a compression of the time from initial design concept to the creation of a final product. Globally, this movement has many names, but "advanced manufacturing" has become the shorthand for this complex integration of material and technology elements that enable new ways to manufacture existing products, as well as new products emerging from new technologies and new design methods. As the breadth of activities associated with advanced manufacturing suggests, there is no single advanced manufacturing industry. Instead, aspects of advanced manufacturing can be identified across a diverse set of business sectors that use manufacturing technologies, ranging from the semiconductors and electronics to the automotive and pharmaceutical industries. The breadth and diversity of advanced manufacturing may change the occupational and environmental risk profile, challenge the basic elements of comprehensive health and safety (material, process, worker, environment, product, and general public health and safety), and provide an opportunity for development and dissemination of occupational and environmental health and safety (OEHS) guidance and best practices. It is unknown how much the risk profile of different elements of OEHS will change, thus requiring an evolution of health and safety practices. These changes may be accomplished most effectively through multi-disciplinary, multi-sector, public-private dialogue that identifies issues and offers solutions.

Advanced Signal Processing Analysis of Laser-Induced Breakdown Spectroscopy Data for the Discrimination of Obsidian Sources

DTIC Science & Technology

2012-02-09

different sources [12,13], but the analytical techniques needed for such analysis (XRD, INAA , & ICP-MS) are time consuming and require expensive...partial least-squares discriminant analysis (PLSDA) that used the SIMPLS solving method [33]. In the experi- ment design, a leave-one-sample-out (LOSO) para...REPORT Advanced signal processing analysis of laser-induced breakdown spectroscopy data for the discrimination of obsidian sources 14. ABSTRACT 16

Recent advances in diagnostic microbiology.

PubMed

Bravo, Lulette Tricia C; Procop, Gary W

2009-07-01

The past decade has seen a surge in the development of a variety of molecular diagnostics designed to rapidly identify or characterize medically important microorganisms. We briefly review important advances in molecular microbiology, and then discuss specific assays that have been implemented in clinical microbiology laboratories throughout the country. We also discuss emerging methods and technologies that will soon be more widely used for the prompt and accurate detection of the agents of infectious diseases.

Model-based design of experiments for cellular processes.

PubMed

Chakrabarty, Ankush; Buzzard, Gregery T; Rundell, Ann E

2013-01-01

Model-based design of experiments (MBDOE) assists in the planning of highly effective and efficient experiments. Although the foundations of this field are well-established, the application of these techniques to understand cellular processes is a fertile and rapidly advancing area as the community seeks to understand ever more complex cellular processes and systems. This review discusses the MBDOE paradigm along with applications and challenges within the context of cellular processes and systems. It also provides a brief tutorial on Fisher information matrix (FIM)-based and Bayesian experiment design methods along with an overview of existing software packages and computational advances that support MBDOE application and adoption within the Systems Biology community. As cell-based products and biologics progress into the commercial sector, it is anticipated that MBDOE will become an essential practice for design, quality control, and production. Copyright © 2013 Wiley Periodicals, Inc.

Finite Element Modeling of a Semi-Rigid Hybrid Mirror and a Highly Actuated Membrane Mirror as Candidates for the Next Generation Space Telescope

NASA Technical Reports Server (NTRS)

Craig, Larry; Jacobson, Dave; Mosier, Gary; Nein, Max; Page, Timothy; Redding, Dave; Sutherlin, Steve; Wilkerson, Gary

2000-01-01

Advanced space telescopes, which will eventually replace the Hubble Space Telescope (HTS), will have apertures of 8 - 20 n. Primary mirrors of these dimensions will have to be foldable to fit into the space launcher. By necessity these mirrors will be extremely light weight and flexible and the historical approaches to mirror designs, where the mirror is made as rigid as possible to maintain figure and to serve as the anchor for the entire telescope, cannot be applied any longer. New design concepts and verifications will depend entirely on analytical methods to predict optical performance. Finite element modeling of the structural and thermal behavior of such mirrors is becoming the tool for advanced space mirror designs. This paper discusses some of the preliminary tasks and study results, which are currently the basis for the design studies of the Next Generation Space Telescope.

Ethical considerations of neuro-oncology trial design in the era of precision medicine.

PubMed

Gupta, Saksham; Smith, Timothy R; Broekman, Marike L

2017-08-01

The field of oncology is currently undergoing a paradigm shift. Advances in the understanding of tumor biology and in tumor sequencing technology have contributed to the shift towards precision medicine, the therapeutic framework of targeting the individual oncogenic changes each tumor harbors. The success of precision medicine therapies, such as targeted kinase inhibitors and immunotherapies, in other cancers have motivated studies in brain cancers. The high specificity and cost of these therapies also encourage a shift in clinical trial design away from randomized control trials towards smaller, more exclusive early phase clinical trials. While these new trials advance the clinical application of increasingly precise and individualized therapies, their design brings ethical challenges . We review the pertinent ethical considerations for clinical trials of precision medicine in neuro-oncology and discuss methods to protect patients in this new era of trial design.

Adaptive Design of Confirmatory Trials: Advances and Challenges

PubMed Central

Lai, Tze Leung; Lavori, Philip W.; Tsang, Ka Wai

2015-01-01

The past decade witnessed major developments in innovative designs of confirmatory clinical trials, and adaptive designs represent the most active area of these developments. We give an overview of the developments and associated statistical methods in several classes of adaptive designs of confirmatory trials. We also discuss their statistical difficulties and implementation challenges, and show how these problems are connected to other branches of mainstream Statistics, which we then apply to resolve the difficulties and bypass the bottlenecks in the development of adaptive designs for the next decade. PMID:26079372

Design of advanced ultrasonic transducers for welding devices.

PubMed

Parrini, L

2001-11-01

A new high frequency ultrasonic transducer has been conceived, designed, prototyped, and tested. In the design phase, an advanced approach was used and established. The method is based on an initial design estimate obtained with finite element method (FEM) simulations. The simulated ultrasonic transducers and resonators are then built and characterized experimentally through laser interferometry and electrical resonance spectra. The comparison of simulation results with experimental data allows the parameters of FEM models to be adjusted and optimized. The achieved FEM simulations exhibit a remarkably high predictive potential and allow full control of the vibration behavior of the transducer. The new transducer is mounted on a wire bonder with a flange whose special geometry was calculated by means of FEM simulations. This flange allows the transducer to be attached on the wire bonder, not only in longitudinal nodes, but also in radial nodes of the ultrasonic field excited in the horn. This leads to a total decoupling of the transducer to the wire bonder, which has not been achieved so far. The new approach to mount ultrasonic transducers on a welding device is of major importance, not only for wire bonding, but also for all high power ultrasound applications and has been patented.

Advanced Technology Composite Fuselage-Structural Performance

NASA Technical Reports Server (NTRS)

Walker, T. H.; Minguet, P. J.; Flynn, B. W.; Carbery, D. J.; Swanson, G. D.; Ilcewicz, L. B.

1997-01-01

Boeing is studying the technologies associated with the application of composite materials to commercial transport fuselage structure under the NASA-sponsored contracts for Advanced Technology Composite Aircraft Structures (ATCAS) and Materials Development Omnibus Contract (MDOC). This report addresses the program activities related to structural performance of the selected concepts, including both the design development and subsequent detailed evaluation. Design criteria were developed to ensure compliance with regulatory requirements and typical company objectives. Accurate analysis methods were selected and/or developed where practical, and conservative approaches were used where significant approximations were necessary. Design sizing activities supported subsequent development by providing representative design configurations for structural evaluation and by identifying the critical performance issues. Significant program efforts were directed towards assessing structural performance predictive capability. The structural database collected to perform this assessment was intimately linked to the manufacturing scale-up activities to ensure inclusion of manufacturing-induced performance traits. Mechanical tests were conducted to support the development and critical evaluation of analysis methods addressing internal loads, stability, ultimate strength, attachment and splice strength, and damage tolerance. Unresolved aspects of these performance issues were identified as part of the assessments, providing direction for future development.

Advanced turbocharger design study program

NASA Technical Reports Server (NTRS)

Culy, D. G.; Heldenbrand, R. W.; Richardson, N. R.

1984-01-01

The advanced Turbocharger Design Study consisted of: (1) the evaluation of three advanced engine designs to determine their turbocharging requirements, and of technologies applicable to advanced turbocharger designs; (2) trade-off studies to define a turbocharger conceptual design and select the engine with the most representative requirements for turbocharging; (3) the preparation of a turbocharger conceptual design for the Curtiss Wright RC2-32 engine selected in the trade-off studies; and (4) the assessment of market impact and the preparation of a technology demonstration plan for the advanced turbocharger.

Use of High Fidelity Methods in Multidisciplinary Optimization-A Preliminary Survey

NASA Technical Reports Server (NTRS)

Guruswamy, Guru P.; Kwak, Dochan (Technical Monitor)

2002-01-01

Multidisciplinary optimization is a key element of design process. To date multidiscipline optimization methods that use low fidelity methods are well advanced. Optimization methods based on simple linear aerodynamic equations and plate structural equations have been applied to complex aerospace configurations. However, use of high fidelity methods such as the Euler/ Navier-Stokes for fluids and 3-D (three dimensional) finite elements for structures has begun recently. As an activity of Multidiscipline Design Optimization Technical Committee (MDO TC) of AIAA (American Institute of Aeronautics and Astronautics), an effort was initiated to assess the status of the use of high fidelity methods in multidisciplinary optimization. Contributions were solicited through the members MDO TC committee. This paper provides a summary of that survey.

Multiscale Modeling in the Clinic: Drug Design and Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clancy, Colleen E.; An, Gary; Cannon, William R.

A wide range of length and time scales are relevant to pharmacology, especially in drug development, drug design and drug delivery. Therefore, multi-scale computational modeling and simulation methods and paradigms that advance the linkage of phenomena occurring at these multiple scales have become increasingly important. Multi-scale approaches present in silico opportunities to advance laboratory research to bedside clinical applications in pharmaceuticals research. This is achievable through the capability of modeling to reveal phenomena occurring across multiple spatial and temporal scales, which are not otherwise readily accessible to experimentation. The resultant models, when validated, are capable of making testable predictions tomore » guide drug design and delivery. In this review we describe the goals, methods, and opportunities of multi-scale modeling in drug design and development. We demonstrate the impact of multiple scales of modeling in this field. We indicate the common mathematical techniques employed for multi-scale modeling approaches used in pharmacology and present several examples illustrating the current state-of-the-art regarding drug development for: Excitable Systems (Heart); Cancer (Metastasis and Differentiation); Cancer (Angiogenesis and Drug Targeting); Metabolic Disorders; and Inflammation and Sepsis. We conclude with a focus on barriers to successful clinical translation of drug development, drug design and drug delivery multi-scale models.« less

Design of multifunctional nanoparticles for combined in-vivo imaging and advanced drug delivery

NASA Astrophysics Data System (ADS)

Leary, James F.

2018-02-01

Design of multifunctional nanoparticles for multimodal in-vivo imaging and advanced targeting to diseased single cells for massive parallel processing nanomedicine approaches requires careful overall design and a multilayered approach. Initial core materials can include non-toxic metals which not only serve as an x-ray contrast agent for CAT scan imaging, but can contain T1 or T2 contrast agents for MRI imaging. One choice is superparamagnetic iron oxide NPs which also allow for convenient magnetic manipulation during manufacturing but also for re-positioning inside the body and for single cell hyperthermia therapies. To permit real-time fluorescence-guided surgery, fluorescence molecules can be included. Advanced targeting can be achieved by attaching antibodies, peptides, aptamers, or other targeting molecules to the nanoparticle in a multilayered approach producing "programmable nanoparticles" whereby the "programming" means controlling a sequence of multi-step targeting methods. Addition of membrane permeating peptides can facilitate uptake by the cell. Addition of "stealth" molecules (e.g. PEG or chitosan) to the outer surfaces of the nanoparticles can permit greatly enhanced circulation times in-vivo which in turn lead to lower amounts of drug exposure to the patient which can reduce undesirable side effects. Nanoparticles with incomplete layers can be removed by affinity purification methods to minimize mistargeting events in-vivo. Nanoscale imaging of these manufactured, multifunctional nanoparticles can be achieved either directly through superresolution microscopy or indirectly through single nanoparticle zeta-sizing or x-ray correlation microscopy. Since these multifunctional nanoparticles are best analyzed by technologies permitting analysis in aqueous environments, superresolution microscopy is, in most cases, the preferred method.

Learning from Research on Teaching: Perspective, Methodology, and Representation. Advances in Research on Teaching. Volume 11

ERIC Educational Resources Information Center

Brophy, Jere, Ed.; Pinnegar, Stefinee, Ed.

2005-01-01

This volume is designed to accomplish three primary purposes: (1) illustrate a variety of qualitative methods that researchers have used to study teaching and teacher education; (2) assess the affordances and constraints of these methods and the ways that they focus and shape explorations of teaching; and (3) illuminate representative questions…

Synthesis of engineering designs of drilling facilities

NASA Astrophysics Data System (ADS)

Porozhsky, K.

2018-03-01

The article sets forth key principles of engineering of drilling equipment based on successive analysis of the goals of the production method, technologies of its implementation and conditions of mineral mining using a new approach to systematization of drilling methods. Potential advancement in the technologies and equipment of drilling is illustrated in terms of oil-well drilling.

LTN Inlets and Nozzles Branch Overview; NASA GE - Methods Development Review

NASA Technical Reports Server (NTRS)

Long-Davis, Mary Jo

2017-01-01

LTNInlets and Nozzles Branch Overview to be presented to GE during method review meeting. Presentation outlines the capabilities, facilities and tools used by the LTN Branch to conduct its mission of developing design and analysis tools and technologies for inlets and nozzles used on advanced vehicle concepts ranging from subsonic to hypersonic speeds.

Design of Rail Instrumentation for Wind Tunnel Sonic Boom Measurements and Computational-Experimental Comparisons

NASA Technical Reports Server (NTRS)

Cliff, Susan E.; Elmiligui, A.; Aftosmis, M.; Morgenstern, J.; Durston, D.; Thomas, S.

2012-01-01

An innovative pressure rail concept for wind tunnel sonic boom testing of modern aircraft configurations with very low overpressures was designed with an adjoint-based solution-adapted Cartesian grid method. The computational method requires accurate free-air calculations of a test article as well as solutions modeling the influence of rail and tunnel walls. Specialized grids for accurate Euler and Navier-Stokes sonic boom computations were used on several test articles including complete aircraft models with flow-through nacelles. The computed pressure signatures are compared with recent results from the NASA 9- x 7-foot Supersonic Wind Tunnel using the advanced rail design.

The NASA/industry Design Analysis Methods for Vibrations (DAMVIBS) Program: A government overview

NASA Technical Reports Server (NTRS)

Kvaternik, Raymond G.

1992-01-01

LaRC, under the Design Analysis Methods for Vibrations (DAMVIBS) Program, set out in 1984 to establish the technology base needed by the rotorcraft industry for developing an advanced finite-element-based dynamics design analysis capability for vibrations. Considerable work was performed by the industry participants in the program since that time. Because the DAMVIBS Program is being phased out, a government/industry assessment of the program was made to identify those accomplishments and contributions which may be ascribed to the program. The purpose is to provide an overview of the program and its accomplishments and contributions from the perspective of the government sponsoring organization.

HOM frequency control of SRF cavity in high current ERLs

NASA Astrophysics Data System (ADS)

Xu, Chen; Ben-Zvi, Ilan

2018-03-01

The acceleration of high-current beam in Superconducting Radio Frequency (SRF) cavities is a challenging but essential for a variety of advanced accelerators. SRF cavities should be carefully designed to minimize the High Order Modes (HOM) power generated in the cavities by the beam current. The reduction of HOM power we demonstrate in a particular case can be quite large. This paper presents a method to systematically control the HOM resonance frequencies in the initial design phase to minimize the HOM power generation. This method is expected to be beneficial for the design of high SRF cavities addressing a variety of Energy Recovery Linac (ERL) applications.

Visualization-based decision support for value-driven system design

NASA Astrophysics Data System (ADS)

Tibor, Elliott

In the past 50 years, the military, communication, and transportation systems that permeate our world, have grown exponentially in size and complexity. The development and production of these systems has seen ballooning costs and increased risk. This is particularly critical for the aerospace industry. The inability to deal with growing system complexity is a crippling force in the advancement of engineered systems. Value-Driven Design represents a paradigm shift in the field of design engineering that has potential to help counteract this trend. The philosophy of Value-Driven Design places the desires of the stakeholder at the forefront of the design process to capture true preferences and reveal system alternatives that were never previously thought possible. Modern aerospace engineering design problems are large, complex, and involve multiple levels of decision-making. To find the best design, the decision-maker is often required to analyze hundreds or thousands of combinations of design variables and attributes. Visualization can be used to support these decisions, by communicating large amounts of data in a meaningful way. Understanding the design space, the subsystem relationships, and the design uncertainties is vital to the advancement of Value-Driven Design as an accepted process for the development of more effective, efficient, robust, and elegant aerospace systems. This research investigates the use of multi-dimensional data visualization tools to support decision-making under uncertainty during the Value-Driven Design process. A satellite design system comprising a satellite, ground station, and launch vehicle is used to demonstrate effectiveness of new visualization methods to aid in decision support during complex aerospace system design. These methods are used to facilitate the exploration of the feasible design space by representing the value impact of system attribute changes and comparing the results of multi-objective optimization formulations with a Value-Driven Design formulation. The visualization methods are also used to assist in the decomposition of a value function, by representing attribute sensitivities to aid with trade-off studies. Lastly, visualization is used to enable greater understanding of the subsystem relationships, by displaying derivative-based couplings, and the design uncertainties, through implementation of utility theory. The use of these visualization methods is shown to enhance the decision-making capabilities of the designer by granting them a more holistic view of the complex design space.

Recent developments of axial flow compressors under transonic flow conditions

NASA Astrophysics Data System (ADS)

Srinivas, G.; Raghunandana, K.; Satish Shenoy, B.

2017-05-01

The objective of this paper is to give a holistic view of the most advanced technology and procedures that are practiced in the field of turbomachinery design. Compressor flow solver is the turbulence model used in the CFD to solve viscous problems. The popular techniques like Jameson’s rotated difference scheme was used to solve potential flow equation in transonic condition for two dimensional aero foils and later three dimensional wings. The gradient base method is also a popular method especially for compressor blade shape optimization. Various other types of optimization techniques available are Evolutionary algorithms (EAs) and Response surface methodology (RSM). It is observed that in order to improve compressor flow solver and to get agreeable results careful attention need to be paid towards viscous relations, grid resolution, turbulent modeling and artificial viscosity, in CFD. The advanced techniques like Jameson’s rotated difference had most substantial impact on wing design and aero foil. For compressor blade shape optimization, Evolutionary algorithm is quite simple than gradient based technique because it can solve the parameters simultaneously by searching from multiple points in the given design space. Response surface methodology (RSM) is a method basically used to design empirical models of the response that were observed and to study systematically the experimental data. This methodology analyses the correct relationship between expected responses (output) and design variables (input). RSM solves the function systematically in a series of mathematical and statistical processes. For turbomachinery blade optimization recently RSM has been implemented successfully. The well-designed high performance axial flow compressors finds its application in any air-breathing jet engines.

Probabilistic boundary element method

NASA Technical Reports Server (NTRS)

Cruse, T. A.; Raveendra, S. T.

1989-01-01

The purpose of the Probabilistic Structural Analysis Method (PSAM) project is to develop structural analysis capabilities for the design analysis of advanced space propulsion system hardware. The boundary element method (BEM) is used as the basis of the Probabilistic Advanced Analysis Methods (PADAM) which is discussed. The probabilistic BEM code (PBEM) is used to obtain the structural response and sensitivity results to a set of random variables. As such, PBEM performs analogous to other structural analysis codes such as finite elements in the PSAM system. For linear problems, unlike the finite element method (FEM), the BEM governing equations are written at the boundary of the body only, thus, the method eliminates the need to model the volume of the body. However, for general body force problems, a direct condensation of the governing equations to the boundary of the body is not possible and therefore volume modeling is generally required.

The social and behavioral influences (SBI) study: study design and rationale for studying the effects of race and activation on cancer pain management.

PubMed

Elias, Cezanne M; Shields, Cleveland G; Griggs, Jennifer J; Fiscella, Kevin; Christ, Sharon L; Colbert, Joseph; Henry, Stephen G; Hoh, Beth G; Hunte, Haslyn E R; Marshall, Mary; Mohile, Supriya Gupta; Plumb, Sandy; Tejani, Mohamedtaki A; Venuti, Alison; Epstein, Ronald M

2017-08-25

Racial disparities exist in the care provided to advanced cancer patients. This article describes an investigation designed to advance the science of healthcare disparities by isolating the effects of patient race and patient activation on physician behavior using novel standardized patient (SP) methodology. The Social and Behavioral Influences (SBI) Study is a National Cancer Institute sponsored trial conducted in Western New York State, Northern/Central Indiana, and lower Michigan. The trial uses an incomplete randomized block design, randomizing physicians to see patients who are either black or white and who are "typical" or "activated" (e.g., ask questions, express opinions, ask for clarification, etc.). The study will enroll 91 physicians. The SBI study addresses important gaps in our knowledge about racial disparities and methods to reduce them in patients with advanced cancer by using standardized patient methodology. This study is innovative in aims, design, and methodology and will point the way to interventions that can reduce racial disparities and discrimination and draw links between implicit attitudes and physician behaviors. https://clinicaltrials.gov/ , #NCT01501006, November 30, 2011.

Recent progress in design and hybridization of planar grating-based transceivers

NASA Astrophysics Data System (ADS)

Bidnyk, S.; Pearson, M.; Balakrishnan, A.; Gao, M.

2007-06-01

We report on recent progress in simulations, physical layout, fabrication and hybridization of planar grating-based transceivers for passive optical networks (PONs). Until recently, PON transceivers have been manufactured using bulk micro-optical components. Today, advancements in modeling and simulation techniques has made it possible to design complex elements in the same silica-on silicon PLC platform and create an alternative platform for manufacturing of bi-directional transceivers. In our chips we simulated an integrated chip that monolithically combined planar reflective gratings and cascaded Mach-Zehnder interferometers. We used a combination of the finite element method and beam propagation method to model cascaded interferometers with enhanced coupling coefficients. Our simulations show that low-diffraction order planar reflective gratings, designed for small incidence and reflection angles, possess the required dispersion strength to meet the PON specifications. Subsequently, we created structures for passive alignment and hybridized photodetectors and lasers. We believe that advancements in simulation of planar lightwave circuits with embedded planar reflective gratings will result in displacement of the thin-film filters (TFFs) technology in many applications that require a high degree of monolithic and hybrid integration.

An evolving-requirements technology assessment process for advanced propulsion concepts

NASA Astrophysics Data System (ADS)

McClure, Erin Kathleen

The following dissertation investigates the development of a methodology suitable for the evaluation of advanced propulsion concepts. At early stages of development, both the future performance of these concepts and their requirements are highly uncertain, making it difficult to forecast their future value. Developing advanced propulsion concepts requires a huge investment of resources. The methodology was developed to enhance the decision-makers understanding of the concepts, so that they could mitigate the risks associated with developing such concepts. A systematic methodology to identify potential advanced propulsion concepts and assess their robustness is necessary to reduce the risk of developing advanced propulsion concepts. Existing advanced design methodologies have evaluated the robustness of technologies or concepts to variations in requirements, but they are not suitable to evaluate a large number of dissimilar concepts. Variations in requirements have been shown to impact the development of advanced propulsion concepts, and any method designed to evaluate these concepts must incorporate the possible variations of the requirements into the assessment. In order to do so, a methodology was formulated to be capable of accounting for two aspects of the problem. First, it had to systemically identify a probabilistic distribution for the future requirements. Such a distribution would allow decision-makers to quantify the uncertainty introduced by variations in requirements. Second, the methodology must be able to assess the robustness of the propulsion concepts as a function of that distribution. This dissertation describes in depth these enabling elements and proceeds to synthesize them into a new method, the Evolving Requirements Technology Assessment (ERTA). As a proof of concept, the ERTA method was used to evaluate and compare advanced propulsion systems that will be capable of powering a hurricane tracking, High Altitude, Long Endurance (HALE) unmanned aerial vehicle (UAV). The use of the ERTA methodology to assess HALE UAV propulsion concepts demonstrated that potential variations in requirements do significantly impact the assessment and selection of propulsion concepts. The proof of concept also demonstrated that traditional forecasting techniques, such as the cross impact analysis, could be used to forecast the requirements for advanced propulsion concepts probabilistically. "Fitness", a measure of relative goodness, was used to evaluate the concepts. Finally, stochastic optimizations were used to evaluate the propulsion concepts across the range of requirement sets that were considered.

Finite Element Methods for Modelling Mechanical Loss in LIGO coating optics.

NASA Astrophysics Data System (ADS)

Newport, Jonathan; Harry, Gregg; LIGO Collaboration

2015-04-01

Gravitational waves from sources such as binary star systems, supernovae explosions and stochastic background radiation have yet to be directly detected by experimental observations. Alongside international collaborators, the Laser Interferometer Gravitational-Wave Observatory (LIGO) is designed to realize detection of gravitational waves using interferometric techniques. The second generation of gravitational wave observatories, known as Advanced LIGO, are currently undergoing installation and commissioning at sites in Hanford, Washington and Livingston, Louisiana. The ultimate sensitivity of Advanced LIGO within select spectral bands is limited by thermal noise in the coatings of the interferometer optics. The LIGO lab at American University is measuring the mechanical loss of coated substrates to predict thermal noise within these spectral bands. These predictions use increasingly sophisticated finite element models to ensure the ultimate design sensitivity of Advanced LIGO and to study coating and substrate materials for future gravitational wave detectors.

Advances in urban-drainage management and flood protection.

PubMed

Verworn, Hans-Reinhard

2002-07-15

Since the beginning of modern urban drainage in the 19th century, the sole objective has been to get rid of sewage and storm water in the best possible way and design the systems according to accepted standards. In recent decades, advanced methods have been developed not only to refine the design but also especially to enable the assessment of hydraulic performance and pollutant emissions. Consequently, urban drainage has become part of an integrated approach concerning flood protection as well as ecological aspects for whole watersheds. Another major change concerns the management of urban systems: simple structural maintenance has been replaced by interactive operational management and control of the systems in order to make better use of the facilities. Rehabilitation has become a multi-objective task. This paper looks at today's basic principles of urban drainage and tomorrow's potential advances, and deals with their relevance to flood protection.

An Experimental Evaluation of Advanced Rotorcraft Airfoils in the NASA Ames Eleven-foot Transonic Wind Tunnel

NASA Technical Reports Server (NTRS)

Flemming, Robert J.

1984-01-01

Five full scale rotorcraft airfoils were tested in the NASA Ames Eleven-Foot Transonic Wind Tunnel for full scale Reynolds numbers at Mach numbers from 0.3 to 1.07. The models, which spanned the tunnel from floor to ceiling, included two modern baseline airfoils, the SC1095 and SC1094 R8, which have been previously tested in other facilities. Three advanced transonic airfoils, designated the SSC-A09, SSC-A07, and SSC-B08, were tested to confirm predicted performance and provide confirmation of advanced airfoil design methods. The test showed that the eleven-foot tunnel is suited to two-dimensional airfoil testing. Maximum lift coefficients, drag coefficients, pitching moments, and pressure coefficient distributions are presented. The airfoil analysis codes agreed well with the data, with the Grumman GRUMFOIL code giving the best overall performance correlation.

Drive-train dynamics technology - State-of-the-art and design of a test facility for advanced development

NASA Technical Reports Server (NTRS)

Badgley, R. H.; Fleming, D. P.; Smalley, A. J.

1975-01-01

A program for the development and verification of drive-train dynamic technology is described along with its basis and the results expected from it. A central feature of this program is a drive-train test facility designed for the testing and development of advanced drive-train components, including shaft systems, dampers, and couplings. Previous efforts in designing flexible dynamic drive-train systems are reviewed, and the present state of the art is briefly summarized. The design of the test facility is discussed with major attention given to the formulation of the test-rig concept, dynamic scaling of model shafts, and the specification of design parameters. Specific efforts envisioned for the test facility are briefly noted, including evaluations of supercritical test shafts, stability thresholds for various sources and types of instabilities that can exist in shaft systems, effects of structural flexibility on the dynamic performance of dampers, and methods for vibration control in two-level and three-level flexible shaft systems.

A Case Study in Design Thinking Applied Through Aviation Mission Support Tactical Advancements for the Next Generation (TANG)

DTIC Science & Technology

2017-12-01

This is an examination of the research, execution, and follow- on developments supporting the Design Thinking event explored through Case Study ...research, execution, and follow- on developments supporting the Design Thinking event explored through case study methods. Additionally, the lenses of...total there have been two Naval Postgraduate School (NPS) case study theses on U.S. Navy innovation events as well as other works examining the

Developing novel 3D antennas using advanced additive manufacturing technology

NASA Astrophysics Data System (ADS)

Mirzaee, Milad

In today's world of wireless communication systems, antenna engineering is rapidly advancing as the wireless services continue to expand in support of emerging commercial applications. Antennas play a key role in the performance of advanced transceiver systems where they serve to convert electric power to electromagnetic waves and vice versa. Researchers have held significant interest in developing this crucial component for wireless communication systems by employing a variety of design techniques. In the past few years, demands for electrically small antennas continues to increase, particularly among portable and mobile wireless devices, medical electronics and aerospace systems. This trend toward smaller electronic devices makes the three dimensional (3D) antennas very appealing, since they can be designed in a way to use every available space inside the devise. Additive Manufacturing (AM) method could help to find great solutions for the antennas design for next generation of wireless communication systems. In this thesis, the design and fabrication of 3D printed antennas using AM technology is studied. To demonstrate this application of AM, different types of antennas structures have been designed and fabricated using various manufacturing processes. This thesis studies, for the first time, embedded conductive 3D printed antennas using PolyLactic Acid (PLA) and Acrylonitrile Butadiene Styrene (ABS) for substrate parts and high temperature carbon paste for conductive parts which can be a good candidate to overcome the limitations of direct printing on 3D surfaces that is the most popular method to fabricate conductive parts of the antennas. This thesis also studies, for the first time, the fabrication of antennas with 3D printed conductive parts which can contribute to the new generation of 3D printed antennas.

A Web-Based Treatment Decision Support Tool for Patients With Advanced Knee Arthritis: Evaluation of User Interface and Content Design

PubMed Central

Zheng, Hua; Rosal, Milagros C; Li, Wenjun; Borg, Amy; Yang, Wenyun; Ayers, David C

2018-01-01

Background Data-driven surgical decisions will ensure proper use and timing of surgical care. We developed a Web-based patient-centered treatment decision and assessment tool to guide treatment decisions among patients with advanced knee osteoarthritis who are considering total knee replacement surgery. Objective The aim of this study was to examine user experience and acceptance of the Web-based treatment decision support tool among older adults. Methods User-centered formative and summative evaluations were conducted for the tool. A sample of 28 patients who were considering total knee replacement participated in the study. Participants’ responses to the user interface design, the clarity of information, as well as usefulness, satisfaction, and acceptance of the tool were collected through qualitative (ie, individual patient interviews) and quantitative (ie, standardized Computer System Usability Questionnaire) methods. Results Participants were older adults with a mean age of 63 (SD 11) years. Three-quarters of them had no technical questions using the tool. User interface design recommendations included larger fonts, bigger buttons, less colors, simpler navigation without extra “next page” click, less mouse movement, and clearer illustrations with simple graphs. Color-coded bar charts and outcome-specific graphs with positive action were easiest for them to understand the outcomes data. Questionnaire data revealed high satisfaction with the tool usefulness and interface quality, and also showed ease of use of the tool, regardless of age or educational status. Conclusions We evaluated the usability of a patient-centered decision support tool designed for advanced knee arthritis patients to facilitate their knee osteoarthritis treatment decision making. The lessons learned can inform other decision support tools to improve interface and content design for older patients’ use. PMID:29712620

Designing and defining dynamic protein cage nanoassemblies in solution

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lai, Y. -T.; Hura, G. L.; Dyer, K. N.

Central challenges in the design of large and dynamic macromolecular assemblies for synthetic biology lie in developing effective methods for testing design strategies and their outcomes, including comprehensive assessments of solution behavior. Here, we created and validated an advanced design of a 600-kDa protein homododecamer that self-assembles into a symmetric tetrahedral cage. The monomeric unit is composed of a trimerizing apex-forming domain genetically linked to an edge-forming dimerizing domain. Enhancing the crystallographic results, high-throughput small-angle x-ray scattering (SAXS) comprehensively contrasted our modifications under diverse solution conditions. To generate a phase diagram associating structure and assembly, we developed force plots thatmore » measure dissimilarity among multiple SAXS data sets. These new tools, which provided effective feedback on experimental constructs relative to design, have general applicability in analyzing the solution behavior of heterogeneous nanosystems and have been made available as a web-based application. Specifically, our results probed the influence of solution conditions and symmetry on stability and structural adaptability, identifying the dimeric interface as the weak point in the assembly. Force plots comparing SAXS data sets further reveal more complex and controllable behavior in solution than captured by our crystal structures. Lastly, these methods for objectively and comprehensively comparing SAXS profiles for systems critically affected by solvent conditions and structural heterogeneity provide an enabling technology for advancing the design and bioengineering of nanoscale biological materials.« less

Designing and defining dynamic protein cage nanoassemblies in solution

DOE PAGES

Lai, Y. -T.; Hura, G. L.; Dyer, K. N.; ...

2016-12-14

Central challenges in the design of large and dynamic macromolecular assemblies for synthetic biology lie in developing effective methods for testing design strategies and their outcomes, including comprehensive assessments of solution behavior. Here, we created and validated an advanced design of a 600-kDa protein homododecamer that self-assembles into a symmetric tetrahedral cage. The monomeric unit is composed of a trimerizing apex-forming domain genetically linked to an edge-forming dimerizing domain. Enhancing the crystallographic results, high-throughput small-angle x-ray scattering (SAXS) comprehensively contrasted our modifications under diverse solution conditions. To generate a phase diagram associating structure and assembly, we developed force plots thatmore » measure dissimilarity among multiple SAXS data sets. These new tools, which provided effective feedback on experimental constructs relative to design, have general applicability in analyzing the solution behavior of heterogeneous nanosystems and have been made available as a web-based application. Specifically, our results probed the influence of solution conditions and symmetry on stability and structural adaptability, identifying the dimeric interface as the weak point in the assembly. Force plots comparing SAXS data sets further reveal more complex and controllable behavior in solution than captured by our crystal structures. Lastly, these methods for objectively and comprehensively comparing SAXS profiles for systems critically affected by solvent conditions and structural heterogeneity provide an enabling technology for advancing the design and bioengineering of nanoscale biological materials.« less

Advances in heterocycle synthesis via [3+m]-cycloaddition reactions involving an azaoxyallyl cation as the key intermediate.

PubMed

Xuan, Jun; Cao, Xia; Cheng, Xiao

2018-05-17

Heterocyclic compounds are widely found in many natural isolates and medicinally relevant compounds, as well as some fine chemicals. The development of general and efficient methods for the construction of heterocyclic compounds is one of the most important tasks in synthetic organic chemistry. Along these lines, [3+m]-cycloaddition reactions involving in situ generated azaoxyallyl cations as the 3-atom units have emerged as a powerful method for the synthesis of nitrogen-containing heterocycles. In this feature article, we highlight recent advances in this rapidly growing area, mainly focusing on the reaction design as well as the reaction mechanism.

Three-Dimensional Printing Based Hybrid Manufacturing of Microfluidic Devices.

PubMed

Alapan, Yunus; Hasan, Muhammad Noman; Shen, Richang; Gurkan, Umut A

2015-05-01

Microfluidic platforms offer revolutionary and practical solutions to challenging problems in biology and medicine. Even though traditional micro/nanofabrication technologies expedited the emergence of the microfluidics field, recent advances in advanced additive manufacturing hold significant potential for single-step, stand-alone microfluidic device fabrication. One such technology, which holds a significant promise for next generation microsystem fabrication is three-dimensional (3D) printing. Presently, building 3D printed stand-alone microfluidic devices with fully embedded microchannels for applications in biology and medicine has the following challenges: (i) limitations in achievable design complexity, (ii) need for a wider variety of transparent materials, (iii) limited z-resolution, (iv) absence of extremely smooth surface finish, and (v) limitations in precision fabrication of hollow and void sections with extremely high surface area to volume ratio. We developed a new way to fabricate stand-alone microfluidic devices with integrated manifolds and embedded microchannels by utilizing a 3D printing and laser micromachined lamination based hybrid manufacturing approach. In this new fabrication method, we exploit the minimized fabrication steps enabled by 3D printing, and reduced assembly complexities facilitated by laser micromachined lamination method. The new hybrid fabrication method enables key features for advanced microfluidic system architecture: (i) increased design complexity in 3D, (ii) improved control over microflow behavior in all three directions and in multiple layers, (iii) transverse multilayer flow and precisely integrated flow distribution, and (iv) enhanced transparency for high resolution imaging and analysis. Hybrid manufacturing approaches hold great potential in advancing microfluidic device fabrication in terms of standardization, fast production, and user-independent manufacturing.

Three-Dimensional Printing Based Hybrid Manufacturing of Microfluidic Devices

PubMed Central

Shen, Richang; Gurkan, Umut A.

2016-01-01

Microfluidic platforms offer revolutionary and practical solutions to challenging problems in biology and medicine. Even though traditional micro/nanofabrication technologies expedited the emergence of the microfluidics field, recent advances in advanced additive manufacturing hold significant potential for single-step, stand-alone microfluidic device fabrication. One such technology, which holds a significant promise for next generation microsystem fabrication is three-dimensional (3D) printing. Presently, building 3D printed stand-alone microfluidic devices with fully embedded microchannels for applications in biology and medicine has the following challenges: (i) limitations in achievable design complexity, (ii) need for a wider variety of transparent materials, (iii) limited z-resolution, (iv) absence of extremely smooth surface finish, and (v) limitations in precision fabrication of hollow and void sections with extremely high surface area to volume ratio. We developed a new way to fabricate stand-alone microfluidic devices with integrated manifolds and embedded microchannels by utilizing a 3D printing and laser micromachined lamination based hybrid manufacturing approach. In this new fabrication method, we exploit the minimized fabrication steps enabled by 3D printing, and reduced assembly complexities facilitated by laser micromachined lamination method. The new hybrid fabrication method enables key features for advanced microfluidic system architecture: (i) increased design complexity in 3D, (ii) improved control over microflow behavior in all three directions and in multiple layers, (iii) transverse multilayer flow and precisely integrated flow distribution, and (iv) enhanced transparency for high resolution imaging and analysis. Hybrid manufacturing approaches hold great potential in advancing microfluidic device fabrication in terms of standardization, fast production, and user-independent manufacturing. PMID:27512530

Climbing with adhesion: from bioinspiration to biounderstanding

PubMed Central

Cutkosky, Mark R.

2015-01-01

Bioinspiration is an increasingly popular design paradigm, especially as robots venture out of the laboratory and into the world. Animals are adept at coping with the variability that the world imposes. With advances in scientific tools for understanding biological structures in detail, we are increasingly able to identify design features that account for animals' robust performance. In parallel, advances in fabrication methods and materials are allowing us to engineer artificial structures with similar properties. The resulting robots become useful platforms for testing hypotheses about which principles are most important. Taking gecko-inspired climbing as an example, we show that the process of extracting principles from animals and adapting them to robots provides insights for both robotics and biology. PMID:26464786

System reliability approaches for advanced propulsion system structures

NASA Technical Reports Server (NTRS)

Cruse, T. A.; Mahadevan, S.

1991-01-01

This paper identifies significant issues that pertain to the estimation and use of system reliability in the design of advanced propulsion system structures. Linkages between the reliabilities of individual components and their effect on system design issues such as performance, cost, availability, and certification are examined. The need for system reliability computation to address the continuum nature of propulsion system structures and synergistic progressive damage modes has been highlighted. Available system reliability models are observed to apply only to discrete systems. Therefore a sequential structural reanalysis procedure is formulated to rigorously compute the conditional dependencies between various failure modes. The method is developed in a manner that supports both top-down and bottom-up analyses in system reliability.

Laser-assisted advanced assembly for MEMS fabrication

NASA Astrophysics Data System (ADS)

Atanasov, Yuriy Andreev

Micro Electro-Mechanical Systems (MEMS) are currently fabricated using methods originally designed for manufacturing semiconductor devices, using minimum if any assembly at all. The inherited limitations of this approach narrow the materials that can be employed and reduce the design complexity, imposing limitations on MEMS functionality. The proposed Laser-Assisted Advanced Assembly (LA3) method solves these problems by first fabricating components followed by assembly of a MEMS device. Components are micro-machined using a laser or by photolithography followed by wet/dry etching out of any material available in a thin sheet form. A wide range of materials can be utilized, including biocompatible metals, ceramics, polymers, composites, semiconductors, and materials with special properties such as memory shape alloys, thermoelectric, ferromagnetic, piezoelectric, and more. The approach proposed allows enhancing the structural and mechanical properties of the starting materials through heat treatment, tribological coatings, surface modifications, bio-functionalization, and more, a limited, even unavailable possibility with existing methods. Components are transferred to the substrate for assembly using the thermo-mechanical Selective Laser Assisted Die Transfer (tmSLADT) mechanism for microchips assembly, already demonstrated by our team. Therefore, the mechanical and electronic part of the MEMS can be fabricated using the same equipment/method. The viability of the Laser-Assisted Advanced Assembly technique for MEMS is demonstrated by fabricating magnetic switches for embedding in a conductive carbon-fiber metamaterial for use in an Electromagnetic-Responsive Mobile Cyber-Physical System (E-RMCPS), which is expected to improve the wireless communication system efficiency within a battery-powered device.

Method and apparatus for rapid thrust increases in a turbofan engine

NASA Technical Reports Server (NTRS)

Cornett, J. E.; Corley, R. C.; Fraley, T. O.; Saunders, A. A., Jr. (Inventor)

1980-01-01

Upon a landing approach, the normal compressor stator schedule of a fan speed controlled turbofan engine is temporarily varied to substantially close the stators to thereby increase the fuel flow and compressor speed in order to maintain fan speed and thrust. This running of the compressor at an off-design speed substantially reduces the time required to subsequently advance the engine speed to the takeoff thrust level by advancing the throttle and opening the compressor stators.

Current status and future prospects for enabling chemistry technology in the drug discovery process.

PubMed

Djuric, Stevan W; Hutchins, Charles W; Talaty, Nari N

2016-01-01

This review covers recent advances in the implementation of enabling chemistry technologies into the drug discovery process. Areas covered include parallel synthesis chemistry, high-throughput experimentation, automated synthesis and purification methods, flow chemistry methodology including photochemistry, electrochemistry, and the handling of "dangerous" reagents. Also featured are advances in the "computer-assisted drug design" area and the expanding application of novel mass spectrometry-based techniques to a wide range of drug discovery activities.

DAKOTA Design Analysis Kit for Optimization and Terascale

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adams, Brian M.; Dalbey, Keith R.; Eldred, Michael S.

2010-02-24

The DAKOTA (Design Analysis Kit for Optimization and Terascale Applications) toolkit provides a flexible and extensible interface between simulation codes (computational models) and iterative analysis methods. By employing object-oriented design to implement abstractions of the key components required for iterative systems analyses, the DAKOTA toolkit provides a flexible and extensible problem-solving environment for design and analysis of computational models on high performance computers.A user provides a set of DAKOTA commands in an input file and launches DAKOTA. DAKOTA invokes instances of the computational models, collects their results, and performs systems analyses. DAKOTA contains algorithms for optimization with gradient and nongradient-basedmore » methods; uncertainty quantification with sampling, reliability, polynomial chaos, stochastic collocation, and epistemic methods; parameter estimation with nonlinear least squares methods; and sensitivity/variance analysis with design of experiments and parameter study methods. These capabilities may be used on their own or as components within advanced strategies such as hybrid optimization, surrogate-based optimization, mixed integer nonlinear programming, or optimization under uncertainty. Services for parallel computing, simulation interfacing, approximation modeling, fault tolerance, restart, and graphics are also included.« less

Advancing stream restoration design: a science-based approach using data and methodologies from the agencies

Treesearch

Jessica Palazzolo; Joshua Robinson; Phillip Ellis

2016-01-01

Ecosystem restoration design is a relatively new field of work that requires multi-disciplinary expertise in the natural sciences. Although the field is new, federal agencies and public institutions have spent several decades and millions of dollars researching the sciences and methods that underly restoration activities. However, many restoration practitioners are...

Preliminary candidate advanced avionics system for general aviation

NASA Technical Reports Server (NTRS)

Mccalla, T. M.; Grismore, F. L.; Greatline, S. E.; Birkhead, L. M.

1977-01-01

An integrated avionics system design was carried out to the level which indicates subsystem function, and the methods of overall system integration. Sufficient detail was included to allow identification of possible system component technologies, and to perform reliability, modularity, maintainability, cost, and risk analysis upon the system design. Retrofit to older aircraft, availability of this system to the single engine two place aircraft, was considered.

Challenges to Providing End-of-Life Care to Low-Income Elders with Advanced Chronic Disease: Lessons Learned from a Model Program

ERIC Educational Resources Information Center

Kramer, Betty J.; Auer, Casey

2005-01-01

Purpose: This study explored the challenges in providing end-of-life care to low-income elders with multiple comorbid chronic conditions in a fully "integrated" managed care program, and it highlighted essential recommendations. Design and Methods: A case-study design was used that involved an extensive analysis of qualitative data from five focus…

Field-Induced Texturing of Ceramic Materials for Unparalleled Properties

DTIC Science & Technology

2017-03-01

research for materials-by- design and advanced processing. Invited talk; 17th International Conference on Experimental Mechanics; 2016 Jul; Rhodes...material that could potentially be textured despite its diamagnetic nature. Predictive DFT modeling and experimental testing methods were designed ...presented at the Mater Science Forum; 2007 (unpublished). 71. Sugiyama T, Tahashi M, Sassa K, Asai S. The control of crystal orientation in non -magnetic

Task Design for Students' Work with Basic Theory in Analysis: The Cases of Multidimensional Differentiability and Curve Integrals

ERIC Educational Resources Information Center

Gravesen, Katrine Frovin; Grønbaek, Niels; Winsløw, Carl

2017-01-01

We investigate the challenges students face in the transition from calculus courses, focusing on methods related to the analysis of real valued functions given in closed form, to more advanced courses on analysis where focus is on theoretical structure, including proof. We do so based on task design aiming for a number of generic potentials for…

Additive Manufacturing and High-Performance Computing: a Disruptive Latent Technology

NASA Astrophysics Data System (ADS)

Goodwin, Bruce

2015-03-01

This presentation will discuss the relationship between recent advances in Additive Manufacturing (AM) technology, High-Performance Computing (HPC) simulation and design capabilities, and related advances in Uncertainty Quantification (UQ), and then examines their impacts upon national and international security. The presentation surveys how AM accelerates the fabrication process, while HPC combined with UQ provides a fast track for the engineering design cycle. The combination of AM and HPC/UQ almost eliminates the engineering design and prototype iterative cycle, thereby dramatically reducing cost of production and time-to-market. These methods thereby present significant benefits for US national interests, both civilian and military, in an age of austerity. Finally, considering cyber security issues and the advent of the ``cloud,'' these disruptive, currently latent technologies may well enable proliferation and so challenge both nuclear and non-nuclear aspects of international security.

Advanced model-based FDIR techniques for aerospace systems: Today challenges and opportunities

NASA Astrophysics Data System (ADS)

Zolghadri, Ali

2012-08-01

This paper discusses some trends and recent advances in model-based Fault Detection, Isolation and Recovery (FDIR) for aerospace systems. The FDIR challenges range from pre-design and design stages for upcoming and new programs, to improvement of the performance of in-service flying systems. For space missions, optimization of flight conditions and safe operation is intrinsically related to GNC (Guidance, Navigation & Control) system of the spacecraft and includes sensors and actuators monitoring. Many future space missions will require autonomous proximity operations including fault diagnosis and the subsequent control and guidance recovery actions. For upcoming and future aircraft, one of the main issues is how early and robust diagnosis of some small and subtle faults could contribute to the overall optimization of aircraft design. This issue would be an important factor for anticipating the more and more stringent requirements which would come in force for future environmentally-friendlier programs. The paper underlines the reasons for a widening gap between the advanced scientific FDIR methods being developed by the academic community and technological solutions demanded by the aerospace industry.

A Fast Algorithm for Massively Parallel, Long-Term, Simulation of Complex Molecular Dynamics Systems

NASA Technical Reports Server (NTRS)

Jaramillo-Botero, Andres; Goddard, William A, III; Fijany, Amir

1997-01-01

The advances in theory and computing technology over the last decade have led to enormous progress in applying atomistic molecular dynamics (MD) methods to the characterization, prediction, and design of chemical, biological, and material systems,.

Use of Additional Lighting for Traffic Control and Speed Reduction in Work Zones

DOT National Transportation Integrated Search

2018-02-01

The Federal Highway Administration (FHWA) is seeking new approaches to the design of the next national long-distance travel study- advanced methods of capturing and analyzing travel data to support effective, defensible transportation decision-making...

Advances and trends in structures and dynamics; Proceedings of the Symposium, Washington, DC, October 22-25, 1984

NASA Technical Reports Server (NTRS)

Noor, A. K. (Editor); Hayduk, R. J. (Editor)

1985-01-01

Among the topics discussed are developments in structural engineering hardware and software, computation for fracture mechanics, trends in numerical analysis and parallel algorithms, mechanics of materials, advances in finite element methods, composite materials and structures, determinations of random motion and dynamic response, optimization theory, automotive tire modeling methods and contact problems, the damping and control of aircraft structures, and advanced structural applications. Specific topics covered include structural design expert systems, the evaluation of finite element system architectures, systolic arrays for finite element analyses, nonlinear finite element computations, hierarchical boundary elements, adaptive substructuring techniques in elastoplastic finite element analyses, automatic tracking of crack propagation, a theory of rate-dependent plasticity, the torsional stability of nonlinear eccentric structures, a computation method for fluid-structure interaction, the seismic analysis of three-dimensional soil-structure interaction, a stress analysis for a composite sandwich panel, toughness criterion identification for unidirectional composite laminates, the modeling of submerged cable dynamics, and damping synthesis for flexible spacecraft structures.

Arrow-wing supersonic cruise aircraft structural design concepts evaluation. Volume 2: Sections 7 through 11

NASA Technical Reports Server (NTRS)

Sakata, I. F.; Davis, G. W.

1975-01-01

The materials and advanced producibility methods that offer potential structural mass savings in the design of the primary structure for a supersonic cruise aircraft are identified and reported. A summary of the materials and fabrication techniques selected for this analytical effort is presented. Both metallic and composite material systems were selected for application to a near-term start-of-design technology aircraft. Selective reinforcement of the basic metallic structure was considered as the appropriate level of composite application for the near-term design.

Ion thruster design and analysis

NASA Technical Reports Server (NTRS)

Kami, S.; Schnelker, D. E.

1976-01-01

Questions concerning the mechanical design of a thruster are considered, taking into account differences in the design of an 8-cm and a 30-cm model. The components of a thruster include the thruster shell assembly, the ion extraction electrode assembly, the cathode isolator vaporizer assembly, the neutralizer isolator vaporizer assembly, ground screen and mask, and the main isolator vaporizer assembly. Attention is given to the materials used in thruster fabrication, the advanced manufacturing methods used, details of thruster performance, an evaluation of thruster life, structural and thermal design considerations, and questions of reliability and quality assurance.

A Neural Network Aero Design System for Advanced Turbo-Engines

NASA Technical Reports Server (NTRS)

Sanz, Jose M.

1999-01-01

An inverse design method calculates the blade shape that produces a prescribed input pressure distribution. By controlling this input pressure distribution the aerodynamic design objectives can easily be met. Because of the intrinsic relationship between pressure distribution and airfoil physical properties, a neural network can be trained to choose the optimal pressure distribution that would meet a set of physical requirements. The neural network technique works well not only as an interpolating device but also as an extrapolating device to achieve blade designs from a given database. Two validating test cases are discussed.

Design and fabrication of Rene 41 advanced structural panels. [their performance under axial compression, shear, and bending loads

NASA Technical Reports Server (NTRS)

Greene, B. E.; Northrup, R. F.

1975-01-01

The efficiency was investigated of curved elements in the design of lightweight structural panels under combined loads of axial compression, inplane shear, and bending. The application is described of technology generated in the initial aluminum program to the design and fabrication of Rene 41 panels for subsequent performance tests at elevated temperature. Optimum designs for two panel configurations are presented. The designs are applicable to hypersonic airplane wing structure, and are designed specifically for testing at elevated temperature in the hypersonic wing test structure located at the NASA Flight Research Center. Fabrication methods developed to produce the Rene panels are described, and test results of smaller structural element specimens are presented to verify the design and fabrication methods used. Predicted strengths of the panels under several proposed elevated temperature test load conditions are presented.

Construction concepts and validation of the 3D printed UST_2 modular stellarator

NASA Astrophysics Data System (ADS)

Queral, V.

2015-03-01

High accuracy, geometric complexity and thus high cost of stellarators tend to hinder the advance of stellarator research. Nowadays, new manufacturing methods might be developed for the production of small and middle-size stellarators. The methods should demonstrate advantages with respect common fabrication methods, like casting, cutting, forging and welding, for the construction of advanced highly convoluted modular stellarators. UST2 is a small modular three period quasi-isodynamic stellarator of major radius 0.26 m and plasma volume 10 litres being currently built to validate additive manufacturing (3D printing) for stellarator construction. The modular coils are wound in grooves defined on six 3D printed half period frames designed as light truss structures filled by a strong filler. A geometrically simple assembling configuration has been concocted for UST2 so as to try to lower the cost of the device while keeping the positioning accuracy of the different elements. The paper summarizes the construction and assembling concepts developed, the devised positioning methodology, the design of the coil frames and positioning elements and, an initial validation of the assembling of the components.

Work Domain Analysis Methodology for Development of Operational Concepts for Advanced Reactors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hugo, Jacques

2015-05-01

This report describes a methodology to conduct a Work Domain Analysis in preparation for the development of operational concepts for new plants. This method has been adapted from the classical method described in the literature in order to better deal with the uncertainty and incomplete information typical of first-of-a-kind designs. The report outlines the strategy for undertaking a Work Domain Analysis of a new nuclear power plant and the methods to be used in the development of the various phases of the analysis. Basic principles are described to the extent necessary to explain why and how the classical method wasmore » adapted to make it suitable as a tool for the preparation of operational concepts for a new nuclear power plant. Practical examples are provided of the systematic application of the method and the various presentation formats in the operational analysis of advanced reactors.« less

Development of quantitative radioactive methodologies on paper to determine important lateral-flow immunoassay parameters.

PubMed

Mosley, Garrett L; Nguyen, Phuong; Wu, Benjamin M; Kamei, Daniel T

2016-08-07

The lateral-flow immunoassay (LFA) is a well-established diagnostic technology that has recently seen significant advancements due in part to the rapidly expanding fields of paper diagnostics and paper-fluidics. As LFA-based diagnostics become more complex, it becomes increasingly important to quantitatively determine important parameters during the design and evaluation process. However, current experimental methods for determining these parameters have certain limitations when applied to LFA systems. In this work, we describe our novel methods of combining paper and radioactive measurements to determine nanoprobe molarity, the number of antibodies per nanoprobe, and the forward and reverse rate constants for nanoprobe binding to immobilized target on the LFA test line. Using a model LFA system that detects for the presence of the protein transferrin (Tf), we demonstrate the application of our methods, which involve quantitative experimentation and mathematical modeling. We also compare the results of our rate constant experiments with traditional experiments to demonstrate how our methods more appropriately capture the influence of the LFA environment on the binding interaction. Our novel experimental approaches can therefore more efficiently guide the research process for LFA design, leading to more rapid advancement of the field of paper-based diagnostics.

Methods for comparative evaluation of propulsion system designs for supersonic aircraft

NASA Technical Reports Server (NTRS)

Tyson, R. M.; Mairs, R. Y.; Halferty, F. D., Jr.; Moore, B. E.; Chaloff, D.; Knudsen, A. W.

1976-01-01

The propulsion system comparative evaluation study was conducted to define a rapid, approximate method for evaluating the effects of propulsion system changes for an advanced supersonic cruise airplane, and to verify the approximate method by comparing its mission performance results with those from a more detailed analysis. A table look up computer program was developed to determine nacelle drag increments for a range of parametric nacelle shapes and sizes. Aircraft sensitivities to propulsion parameters were defined. Nacelle shapes, installed weights, and installed performance was determined for four study engines selected from the NASA supersonic cruise aircraft research (SCAR) engine studies program. Both rapid evaluation method (using sensitivities) and traditional preliminary design methods were then used to assess the four engines. The method was found to compare well with the more detailed analyses.

Advancing the role of the pharmacy technician: A systematic review.

PubMed

Mattingly, Ashlee N; Mattingly, T Joseph

To summarize the findings of a literature search on advancing the role of pharmacy technicians, including the types of training identified and the potential costs and benefits to both the technician and the pharmacy. A literature search of Scopus, Embase, and Medline was conducted on January 11, 2017. Original research, research reports, case studies, or association reports were included for review. Articles were considered to be relevant based on identification of an advanced pharmacy technician role or addressing additional training/education for technician functions. A standard data extraction form was used to collect study authors, article title, year published, journal title, study design, brief description of methods, primary outcome measures, advanced technician roles identified, additional education or training addressed, and additional costs and benefits identified in each article. A total of 33 articles were included for full review and data extraction. Study design varied, with 17 (52%) quantitative, 1 (3%) qualitative, 5 (15%) mixed-method, and 10 (30%) case study designs. Seventeen (52%) of the studies included were published after 2006. The mechanism of training was primarily through supervised on-the-job training, allowing technicians to assume administrative-based positions that facilitated a pharmacist-led clinical service, with either the pharmacist or the pharmacy receiving the greatest benefits. Although the literature supports technicians performing advanced roles in the pharmacy, resulting in either improved patient outcomes or opportunities for pharmacists to engage in additional clinical services, the benefits to the technician were primarily indirect, such as an increase in job satisfaction or a more desirable work schedule. If a technician is to take on additional roles that require completion of a formalized training or educational program, benefits that are more tangible may help to inspire technicians to pursue these roles. Copyright © 2018 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Intelligent Engine Systems: Thermal Management and Advanced Cooling

NASA Technical Reports Server (NTRS)

Bergholz, Robert

2008-01-01

The objective of the Advanced Turbine Cooling and Thermal Management program is to develop intelligent control and distribution methods for turbine cooling, while achieving a reduction in total cooling flow and assuring acceptable turbine component safety and reliability. The program also will develop embedded sensor technologies and cooling system models for real-time engine diagnostics and health management. Both active and passive control strategies will be investigated that include the capability of intelligent modulation of flow quantities, pressures, and temperatures both within the supply system and at the turbine component level. Thermal management system concepts were studied, with a goal of reducing HPT blade cooling air supply temperature. An assessment will be made of the use of this air by the active clearance control system as well. Turbine component cooling designs incorporating advanced, high-effectiveness cooling features, will be evaluated. Turbine cooling flow control concepts will be studied at the cooling system level and the component level. Specific cooling features or sub-elements of an advanced HPT blade cooling design will be downselected for core fabrication and casting demonstrations.

Materials and structural aspects of advanced gas-turbine helicopter engines

NASA Technical Reports Server (NTRS)

Freche, J. C.; Acurio, J.

1979-01-01

Advances in materials, coatings, turbine cooling technology, structural and design concepts, and component-life prediction of helicopter gas-turbine-engine components are presented. Stationary parts including the inlet particle separator, the front frame, rotor tip seals, vanes and combustors and rotating components - compressor blades, disks, and turbine blades - are discussed. Advanced composite materials are considered for the front frame and compressor blades, prealloyed powder superalloys will increase strength and reduce costs of disks, the oxide dispersion strengthened alloys will have 100C higher use temperature in combustors and vanes than conventional superalloys, ceramics will provide the highest use temperature of 1400C for stator vanes and 1370C for turbine blades, and directionally solidified eutectics will afford up to 50C temperature advantage at turbine blade operating conditions. Coatings for surface protection at higher surface temperatures and design trends in turbine cooling technology are discussed. New analytical methods of life prediction such as strain gage partitioning for high temperature prediction, fatigue life, computerized prediction of oxidation resistance, and advanced techniques for estimating coating life are described.

Artificial intelligence and design: Opportunities, research problems and directions

NASA Technical Reports Server (NTRS)

Amarel, Saul

1990-01-01

The issues of industrial productivity and economic competitiveness are of major significance in the U.S. at present. By advancing the science of design, and by creating a broad computer-based methodology for automating the design of artifacts and of industrial processes, we can attain dramatic improvements in productivity. It is our thesis that developments in computer science, especially in Artificial Intelligence (AI) and in related areas of advanced computing, provide us with a unique opportunity to push beyond the present level of computer aided automation technology and to attain substantial advances in the understanding and mechanization of design processes. To attain these goals, we need to build on top of the present state of AI, and to accelerate research and development in areas that are especially relevant to design problems of realistic complexity. We propose an approach to the special challenges in this area, which combines 'core work' in AI with the development of systems for handling significant design tasks. We discuss the general nature of design problems, the scientific issues involved in studying them with the help of AI approaches, and the methodological/technical issues that one must face in developing AI systems for handling advanced design tasks. Looking at basic work in AI from the perspective of design automation, we identify a number of research problems that need special attention. These include finding solution methods for handling multiple interacting goals, formation problems, problem decompositions, and redesign problems; choosing representations for design problems with emphasis on the concept of a design record; and developing approaches for the acquisition and structuring of domain knowledge with emphasis on finding useful approximations to domain theories. Progress in handling these research problems will have major impact both on our understanding of design processes and their automation, and also on several fundamental questions that are of intrinsic concern to AI. We present examples of current AI work on specific design tasks, and discuss new directions of research, both as extensions of current work and in the context of new design tasks where domain knowledge is either intractable or incomplete. The domains discussed include Digital Circuit Design, Mechanical Design of Rotational Transmissions, Design of Computer Architectures, Marine Design, Aircraft Design, and Design of Chemical Processes and Materials. Work in these domains is significant on technical grounds, and it is also important for economic and policy reasons.

Composite structural materials

NASA Technical Reports Server (NTRS)

Ansell, G. S.; Loewy, R. G.; Wiberley, S. E.

1983-01-01

Transverse properties of fiber constituents in composites, fatigue in composite materials, matrix dominated properties of high performance composites, numerical investigation of moisture effects, numerical investigation of the micromechanics of composite fracture, advanced analysis methods, compact lug design, and the RP-1 and RP-2 sailplanes projects are discussed.

LOCATING BURIED WORLD WAR 1 MUNITIONS WITH REMOTE SENSING AND GIS

EPA Science Inventory

Remote Sensing is a scientific discipline of non-contact monitoring. It includes a range of technologies that span from aerial photography to advanced spectral imaging and analytical methods. This Session is designed to demonstrate contemporary practical applications of remote ...

Our method of correcting cryptotia.

PubMed

Yanai, A; Tange, I; Bandoh, Y; Tsuzuki, K; Sugino, H; Nagata, S

1988-12-01

Our technique for the correction of cryptotia using both Z-plasty and the advancement flap is described. The main advantages are the simple design of the skin incision and the possibility of its application to cryptotia other than severe cartilage deformity and extreme lack of skin.

Overset Grid Methods Applied to Nonlinear Potential Flows

NASA Technical Reports Server (NTRS)

Holst, Terry; Kwak, Dochan (Technical Monitor)

2000-01-01

The objectives of this viewgraph presentation are to develop Chimera-based potential methodology which is compatible with overflow and overflow infrastructure, creating options for an advanced problem solving environment and to significantly reduce turnaround time for aerodynamic analysis and design (primarily cruise conditions).

Analog-digital simulation of transient-induced logic errors and upset susceptibility of an advanced control system

NASA Technical Reports Server (NTRS)

Carreno, Victor A.; Choi, G.; Iyer, R. K.

1990-01-01

A simulation study is described which predicts the susceptibility of an advanced control system to electrical transients resulting in logic errors, latched errors, error propagation, and digital upset. The system is based on a custom-designed microprocessor and it incorporates fault-tolerant techniques. The system under test and the method to perform the transient injection experiment are described. Results for 2100 transient injections are analyzed and classified according to charge level, type of error, and location of injection.

Composite transport wing technology development: Design development tests and advanced structural concepts

NASA Technical Reports Server (NTRS)

Griffin, Charles F.; Harvill, William E.

1988-01-01

Numerous design concepts, materials, and manufacturing methods were investigated for the covers and spars of a transport box wing. Cover panels and spar segments were fabricated and tested to verify the structural integrity of design concepts and fabrication techniques. Compression tests on stiffened panels demonstrated the ability of graphite/epoxy wing upper cover designs to achieve a 35 percent weight savings compared to the aluminum baseline. The impact damage tolerance of the designs and materials used for these panels limits the allowable compression strain and therefore the maximum achievable weight savings. Bending and shear tests on various spar designs verified an average weight savings of 37 percent compared to the aluminum baseline. Impact damage to spar webs did not significantly degrade structural performance. Predictions of spar web shear instability correlated well with measured performance. The structural integrity of spars manufactured by filament winding equalled or exceeded those fabricated by hand lay-up. The information obtained will be applied to the design, fabrication, and test of a full-scale section of a wing box. When completed, the tests on the technology integration box beam will demonstrate the structural integrity of an advanced composite wing design which is 25 percent lighter than the metal baseline.

HOM frequency control of SRF cavity in high current ERLs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Chen; Ben-Zvi, Ilan

The acceleration of high-current beam in Superconducting Radio Frequency (SRF) cavities is a challenging but essential for a variety of advanced accelerators. SRF cavities should be carefully designed to minimize the High Order Modes (HOM) power generated in the cavities by the beam current. The reduction of HOM power we demonstrate in a particular case can be quite large. This paper presents a method to systematically control the HOM resonance frequencies in the initial design phase to minimize the HOM power generation. This method is expected to be beneficial for the design of high SRF cavities addressing a variety ofmore » Energy Recovery Linac (ERL) applications.« less

HOM frequency control of SRF cavity in high current ERLs

DOE PAGES

Xu, Chen; Ben-Zvi, Ilan

2017-12-06

The acceleration of high-current beam in Superconducting Radio Frequency (SRF) cavities is a challenging but essential for a variety of advanced accelerators. SRF cavities should be carefully designed to minimize the High Order Modes (HOM) power generated in the cavities by the beam current. The reduction of HOM power we demonstrate in a particular case can be quite large. This paper presents a method to systematically control the HOM resonance frequencies in the initial design phase to minimize the HOM power generation. This method is expected to be beneficial for the design of high SRF cavities addressing a variety ofmore » Energy Recovery Linac (ERL) applications.« less

The NASA/industry Design Analysis Methods for Vibrations (DAMVIBS) program: A government overview

NASA Technical Reports Server (NTRS)

Kvaternik, Raymond G.

1993-01-01

NASA-Langley, under the Design Analysis Methods for Vibrations (DAMVIBS) Program, set out in 1984 to establish the technology base needed by the rotorcraft industry for developing an advanced finite-element-based dynamics design analysis capability for vibrations. Considerable work has been done by the industry participants in the program since that time. Because the DAMVIBS Program is being phased out, a government/industry assessment of the program has been made to identify those accomplishments and contributions which may be ascribed to the program. The purpose of this paper is to provide an overview of the program and its accomplishments and contributions from the perspective of the government sponsoring organization.

Test Standard Developed for Determining the Slow Crack Growth of Advanced Ceramics at Ambient Temperature

NASA Technical Reports Server (NTRS)

Choi, Sung R.; Salem, Jonathan A.

1998-01-01

The service life of structural ceramic components is often limited by the process of slow crack growth. Therefore, it is important to develop an appropriate testing methodology for accurately determining the slow crack growth design parameters necessary for component life prediction. In addition, an appropriate test methodology can be used to determine the influences of component processing variables and composition on the slow crack growth and strength behavior of newly developed materials, thus allowing the component process to be tailored and optimized to specific needs. At the NASA Lewis Research Center, work to develop a standard test method to determine the slow crack growth parameters of advanced ceramics was initiated by the authors in early 1994 in the C 28 (Advanced Ceramics) committee of the American Society for Testing and Materials (ASTM). After about 2 years of required balloting, the draft written by the authors was approved and established as a new ASTM test standard: ASTM C 1368-97, Standard Test Method for Determination of Slow Crack Growth Parameters of Advanced Ceramics by Constant Stress-Rate Flexural Testing at Ambient Temperature. Briefly, the test method uses constant stress-rate testing to determine strengths as a function of stress rate at ambient temperature. Strengths are measured in a routine manner at four or more stress rates by applying constant displacement or loading rates. The slow crack growth parameters required for design are then estimated from a relationship between strength and stress rate. This new standard will be published in the Annual Book of ASTM Standards, Vol. 15.01, in 1998. Currently, a companion draft ASTM standard for determination of the slow crack growth parameters of advanced ceramics at elevated temperatures is being prepared by the authors and will be presented to the committee by the middle of 1998. Consequently, Lewis will maintain an active leadership role in advanced ceramics standardization within ASTM. In addition, the authors have been and are involved with several international standardization organizations including the Versailles Project on Advanced Materials and Standards (VAMAS), the International Energy Agency (IEA), and the International Organization for Standardization (ISO). The associated standardization activities involve fracture toughness, strength, elastic modulus, and the machining of advanced ceramics.

Bearing design - Historical aspects, present technology and future problems; Proceedings of the International Conference, San Francisco, CA, August 18-21, 1980

NASA Technical Reports Server (NTRS)

Anderson, W. J.

1980-01-01

The considered investigations deal with some of the more important present day and future bearing requirements, and design methodologies available for coping with them. Solutions to many forthcoming bearing problems lie in the utilization of the most advanced materials, design methods, and lubrication techniques. Attention is given to materials for rolling element bearings, numerical analysis techniques and design methodology for rolling element bearing load support systems, lubrication of rolling element bearings, journal bearing design for high speed turbomachinery, design and energy losses in the case of turbulent flow bearings, and fluid film bearing response to dynamic loading.

Process safety improvement--quality and target zero.

PubMed

Van Scyoc, Karl

2008-11-15

Process safety practitioners have adopted quality management principles in design of process safety management systems with positive effect, yet achieving safety objectives sometimes remain a distant target. Companies regularly apply tools and methods which have roots in quality and productivity improvement. The "plan, do, check, act" improvement loop, statistical analysis of incidents (non-conformities), and performance trending popularized by Dr. Deming are now commonly used in the context of process safety. Significant advancements in HSE performance are reported after applying methods viewed as fundamental for quality management. In pursuit of continual process safety improvement, the paper examines various quality improvement methods, and explores how methods intended for product quality can be additionally applied to continual improvement of process safety. Methods such as Kaizen, Poke yoke, and TRIZ, while long established for quality improvement, are quite unfamiliar in the process safety arena. These methods are discussed for application in improving both process safety leadership and field work team performance. Practical ways to advance process safety, based on the methods, are given.

Machining and characterization of self-reinforced polymers

NASA Astrophysics Data System (ADS)

Deepa, A.; Padmanabhan, K.; Kuppan, P.

2017-11-01

This Paper focuses on obtaining the mechanical properties and the effect of the different machining techniques on self-reinforced composites sample and to derive the best machining method with remarkable properties. Each sample was tested by the Tensile and Flexural tests, fabricated using hot compaction test and those loads were calculated. These composites are machined using conventional methods because of lack of advanced machinery in most of the industries. The advanced non-conventional methods like Abrasive water jet machining were used. These machining techniques are used to get the better output for the composite materials with good mechanical properties compared to conventional methods. But the use of non-conventional methods causes the changes in the work piece, tool properties and more economical compared to the conventional methods. Finding out the best method ideal for the designing of these Self Reinforced Composites with and without defects and the use of Scanning Electron Microscope (SEM) analysis for the comparing the microstructure of the PP and PE samples concludes our process.

Human Modeling for Ground Processing Human Factors Engineering Analysis

NASA Technical Reports Server (NTRS)

Stambolian, Damon B.; Lawrence, Brad A.; Stelges, Katrine S.; Steady, Marie-Jeanne O.; Ridgwell, Lora C.; Mills, Robert E.; Henderson, Gena; Tran, Donald; Barth, Tim

2011-01-01

There have been many advancements and accomplishments over the last few years using human modeling for human factors engineering analysis for design of spacecraft. The key methods used for this are motion capture and computer generated human models. The focus of this paper is to explain the human modeling currently used at Kennedy Space Center (KSC), and to explain the future plans for human modeling for future spacecraft designs

Simple adaptive control system design for a quadrotor with an internal PFC

NASA Astrophysics Data System (ADS)

Mizumoto, Ikuro; Nakamura, Takuto; Kumon, Makoto; Takagi, Taro

2014-12-01

The paper deals with an adaptive control system design problem for a four rotor helicopter or quadrotor. A simple adaptive control design scheme with a parallel feedforward compensator (PFC) in the internal loop of the considered quadrotor will be proposed based on the backstepping strategy. As is well known, the backstepping control strategy is one of the advanced control strategy for nonlinear systems. However, the control algorithm will become complex if the system has higher order relative degrees. We will show that one can skip some design steps of the backstepping method by introducing a PFC in the inner loop of the considered quadrotor, so that the structure of the obtained controller will be simplified and a high gain based adaptive feedback control system will be designed. The effectiveness of the proposed method will be confirmed through numerical simulations.

Computational design and fabrication of a novel bioresorbable cage for tibial tuberosity advancement application.

PubMed

Castilho, Miguel; Rodrigues, Jorge; Vorndran, Elke; Gbureck, Uwe; Quental, Carlos; Folgado, João; Fernandes, Paulo R

2017-01-01

Tibial tuberosity advancement (TTA) is a promising method for the treatment of cruciate ligament rupture in dogs that usually implies the implantation of a titanium cage as bone implant. This cage is non-biodegradable and fails in providing adequate implant-bone tissue integration. The objective of this work is to propose a new process chain for designing and manufacturing an alternative biodegradable cage that can fulfill specific patient requirements. A three-dimensional finite element model (3D FEM) of the TTA system was first created to evaluate the mechanical environment at cage domain during different stages of the dog walk. The cage microstructure was then optimized using a topology optimization tool, which addresses the accessed local mechanical requirements, and at same time ensures the maximum permeability to allow nutrient and oxygen supply to the implant core. The designed cage was then biofabricated by a 3D powder printing of tricalcium phosphate cement. This work demonstrates that the combination of a 3D FEM with a topology optimization approach enabled the design of a novel cage for TTA application with tailored permeability and mechanical properties, that can be successfully 3D printed in a biodegradable bioceramic material. These results support the potential of the design optimization strategy and fabrication method to the development of customized and bioresorbable implants for bone repair. Copyright © 2016 Elsevier Ltd. All rights reserved.

Advancing RF pulse design using an open-competition format: Report from the 2015 ISMRM challenge.

PubMed

Grissom, William A; Setsompop, Kawin; Hurley, Samuel A; Tsao, Jeffrey; Velikina, Julia V; Samsonov, Alexey A

2017-10-01

To advance the best solutions to two important RF pulse design problems with an open head-to-head competition. Two sub-challenges were formulated in which contestants competed to design the shortest simultaneous multislice (SMS) refocusing pulses and slice-selective parallel transmission (pTx) excitation pulses, subject to realistic hardware and safety constraints. Short refocusing pulses are needed for spin echo SMS imaging at high multiband factors, and short slice-selective pTx pulses are needed for multislice imaging in ultra-high field MRI. Each sub-challenge comprised two phases, in which the first phase posed problems with a low barrier of entry, and the second phase encouraged solutions that performed well in general. The Challenge ran from October 2015 to May 2016. The pTx Challenge winners developed a spokes pulse design method that combined variable-rate selective excitation with an efficient method to enforce SAR constraints, which achieved 10.6 times shorter pulse durations than conventional approaches. The SMS Challenge winners developed a time-optimal control multiband pulse design algorithm that achieved 5.1 times shorter pulse durations than conventional approaches. The Challenge led to rapid step improvements in solutions to significant problems in RF excitation for SMS imaging and ultra-high field MRI. Magn Reson Med 78:1352-1361, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

Building Better: Advanced Energy Design Guides - Continuum Magazine |

Science.gov Websites

NREL Building Better: Advanced Energy Design Guides Building Better: Advanced Energy Design Greensburg be constructed to meet Leadership in Energy and Environmental Design (LEED) Platinum ratings from design needs to incorporate a number of recommendations for achieving energy savings over the minimum

Achieving integration in mixed methods designs-principles and practices.

PubMed

Fetters, Michael D; Curry, Leslie A; Creswell, John W

2013-12-01

Mixed methods research offers powerful tools for investigating complex processes and systems in health and health care. This article describes integration principles and practices at three levels in mixed methods research and provides illustrative examples. Integration at the study design level occurs through three basic mixed method designs-exploratory sequential, explanatory sequential, and convergent-and through four advanced frameworks-multistage, intervention, case study, and participatory. Integration at the methods level occurs through four approaches. In connecting, one database links to the other through sampling. With building, one database informs the data collection approach of the other. When merging, the two databases are brought together for analysis. With embedding, data collection and analysis link at multiple points. Integration at the interpretation and reporting level occurs through narrative, data transformation, and joint display. The fit of integration describes the extent the qualitative and quantitative findings cohere. Understanding these principles and practices of integration can help health services researchers leverage the strengths of mixed methods. © Health Research and Educational Trust.

Numerical methods for engine-airframe integration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Murthy, S.N.B.; Paynter, G.C.

1986-01-01

Various papers on numerical methods for engine-airframe integration are presented. The individual topics considered include: scientific computing environment for the 1980s, overview of prediction of complex turbulent flows, numerical solutions of the compressible Navier-Stokes equations, elements of computational engine/airframe integrations, computational requirements for efficient engine installation, application of CAE and CFD techniques to complete tactical missile design, CFD applications to engine/airframe integration, and application of a second-generation low-order panel methods to powerplant installation studies. Also addressed are: three-dimensional flow analysis of turboprop inlet and nacelle configurations, application of computational methods to the design of large turbofan engine nacelles, comparison ofmore » full potential and Euler solution algorithms for aeropropulsive flow field computations, subsonic/transonic, supersonic nozzle flows and nozzle integration, subsonic/transonic prediction capabilities for nozzle/afterbody configurations, three-dimensional viscous design methodology of supersonic inlet systems for advanced technology aircraft, and a user's technology assessment.« less

Advanced Capabilities for Wind Tunnel Testing in the 21st Century

NASA Technical Reports Server (NTRS)

Kegelman, Jerome T.; Danehy, Paul M.; Schwartz, Richard J.

2010-01-01

Wind tunnel testing methods and test technologies for the 21st century using advanced capabilities are presented. These capabilities are necessary to capture more accurate and high quality test results by eliminating the uncertainties in testing and to facilitate verification of computational tools for design. This paper discusses near term developments underway in ground testing capabilities, which will enhance the quality of information of both the test article and airstream flow details. Also discussed is a selection of new capability investments that have been made to accommodate such developments. Examples include advanced experimental methods for measuring the test gas itself; using efficient experiment methodologies, including quality assurance strategies within the test; and increasing test result information density by using extensive optical visualization together with computed flow field results. These points could be made for both major investments in existing tunnel capabilities or for entirely new capabilities.

Genetic engineering for skeletal regenerative medicine.

PubMed

Gersbach, Charles A; Phillips, Jennifer E; García, Andrés J

2007-01-01

The clinical challenges of skeletal regenerative medicine have motivated significant advances in cellular and tissue engineering in recent years. In particular, advances in molecular biology have provided the tools necessary for the design of gene-based strategies for skeletal tissue repair. Consequently, genetic engineering has emerged as a promising method to address the need for sustained and robust cellular differentiation and extracellular matrix production. As a result, gene therapy has been established as a conventional approach to enhance cellular activities for skeletal tissue repair. Recent literature clearly demonstrates that genetic engineering is a principal factor in constructing effective methods for tissue engineering approaches to bone, cartilage, and connective tissue regeneration. This review highlights this literature, including advances in the development of efficacious gene carriers, novel cell sources, successful delivery strategies, and optimal target genes. The current status of the field and the challenges impeding the clinical realization of these approaches are also discussed.

Neural data science: accelerating the experiment-analysis-theory cycle in large-scale neuroscience.

PubMed

Paninski, L; Cunningham, J P

2018-06-01

Modern large-scale multineuronal recording methodologies, including multielectrode arrays, calcium imaging, and optogenetic techniques, produce single-neuron resolution data of a magnitude and precision that were the realm of science fiction twenty years ago. The major bottlenecks in systems and circuit neuroscience no longer lie in simply collecting data from large neural populations, but also in understanding this data: developing novel scientific questions, with corresponding analysis techniques and experimental designs to fully harness these new capabilities and meaningfully interrogate these questions. Advances in methods for signal processing, network analysis, dimensionality reduction, and optimal control-developed in lockstep with advances in experimental neurotechnology-promise major breakthroughs in multiple fundamental neuroscience problems. These trends are clear in a broad array of subfields of modern neuroscience; this review focuses on recent advances in methods for analyzing neural time-series data with single-neuronal precision. Copyright © 2018 Elsevier Ltd. All rights reserved.

Increasing complexity of clinical research in gastroenterology: implications for the training of clinician-scientists.

PubMed

Scott, Frank I; McConnell, Ryan A; Lewis, Matthew E; Lewis, James D

2012-04-01

Significant advances have been made in clinical and epidemiologic research methods over the past 30 years. We sought to demonstrate the impact of these advances on published gastroenterology research from 1980 to 2010. Twenty original clinical articles were randomly selected from each of three journals from 1980, 1990, 2000, and 2010. Each article was assessed for topic, whether the outcome was clinical or physiologic, study design, sample size, number of authors and centers collaborating, reporting of various statistical methods, and external funding. From 1980 to 2010, there was a significant increase in analytic studies, clinical outcomes, number of authors per article, multicenter collaboration, sample size, and external funding. There was increased reporting of P values, confidence intervals, and power calculations, and increased use of large multicenter databases, multivariate analyses, and bioinformatics. The complexity of clinical gastroenterology and hepatology research has increased dramatically, highlighting the need for advanced training of clinical investigators.

AST Combustion Workshop: Diagnostics Working Group Report

NASA Technical Reports Server (NTRS)

Locke, Randy J.; Hicks, Yolanda R.; Hanson, Ronald K.

1996-01-01

A workshop was convened under NASA's Advanced Subsonics Technologies (AST) Program. Many of the principal combustion diagnosticians from industry, academia, and government laboratories were assembled in the Diagnostics/Testing Subsection of this workshop to discuss the requirements and obstacles to the successful implementation of advanced diagnostic techniques to the test environment of the proposed AST combustor. The participants, who represented the major relevant areas of advanced diagnostic methods currently applied to combustion and related fields, first established the anticipated AST combustor flowfield conditions. Critical flow parameters were then examined and prioritized as to their importance to combustor/fuel injector design and manufacture, environmental concerns, and computational interests. Diagnostic techniques were then evaluated in terms of current status, merits and obstacles for each flow parameter. All evaluations are presented in tabular form and recommendations are made on the best-suited diagnostic method to implement for each flow parameter in order of applicability and intrinsic value.

Methodology issues in implementation science.

PubMed

Newhouse, Robin; Bobay, Kathleen; Dykes, Patricia C; Stevens, Kathleen R; Titler, Marita

2013-04-01

Putting evidence into practice at the point of care delivery requires an understanding of implementation strategies that work, in what context and how. To identify methodological issues in implementation science using 4 studies as cases and make recommendations for further methods development. Four cases are presented and methodological issues identified. For each issue raised, evidence on the state of the science is described. Issues in implementation science identified include diverse conceptual frameworks, potential weaknesses in pragmatic study designs, and the paucity of standard concepts and measurement. Recommendations to advance methods in implementation include developing a core set of implementation concepts and metrics, generating standards for implementation methods including pragmatic trials, mixed methods designs, complex interventions and measurement, and endorsing reporting standards for implementation studies.

Characterization and modeling of an advanced flexible thermal protection material for space applications

NASA Technical Reports Server (NTRS)

Clayton, Joseph P.; Tinker, Michael L.

1991-01-01

This paper describes experimental and analytical characterization of a new flexible thermal protection material known as Tailorable Advanced Blanket Insulation (TABI). This material utilizes a three-dimensional ceramic fabric core structure and an insulation filler. TABI is the leading candidate for use in deployable aeroassisted vehicle designs. Such designs require extensive structural modeling, and the most significant in-plane material properties necessary for model development are measured and analytically verified in this study. Unique test methods are developed for damping measurements. Mathematical models are developed for verification of the experimental modulus and damping data, and finally, transverse properties are described in terms of the inplane properties through use of a 12-dof finite difference model of a simple TABI configuration.

Advanced Interval Type-2 Fuzzy Sliding Mode Control for Robot Manipulator.

PubMed

Hwang, Ji-Hwan; Kang, Young-Chang; Park, Jong-Wook; Kim, Dong W

2017-01-01

In this paper, advanced interval type-2 fuzzy sliding mode control (AIT2FSMC) for robot manipulator is proposed. The proposed AIT2FSMC is a combination of interval type-2 fuzzy system and sliding mode control. For resembling a feedback linearization (FL) control law, interval type-2 fuzzy system is designed. For compensating the approximation error between the FL control law and interval type-2 fuzzy system, sliding mode controller is designed, respectively. The tuning algorithms are derived in the sense of Lyapunov stability theorem. Two-link rigid robot manipulator with nonlinearity is used to test and the simulation results are presented to show the effectiveness of the proposed method that can control unknown system well.

Surface Acoustic Wave Vibration Sensors for Measuring Aircraft Flutter

NASA Technical Reports Server (NTRS)

Wilson, William C.; Moore, Jason P.; Juarez, Peter D.

2016-01-01

Under NASA's Advanced Air Vehicles Program the Advanced Air Transport Technology (AATT) Project is investigating flutter effects on aeroelastic wings. To support that work a new method for measuring vibrations due to flutter has been developed. The method employs low power Surface Acoustic Wave (SAW) sensors. To demonstrate the ability of the SAW sensor to detect flutter vibrations the sensors were attached to a Carbon fiber-reinforced polymer (CFRP) composite panel which was vibrated at six frequencies from 1Hz to 50Hz. The SAW data was compared to accelerometer data and was found to resemble sine waves and match each other closely. The SAW module design and results from the tests are presented here.

Robust Airfoil Optimization in High Resolution Design Space

NASA Technical Reports Server (NTRS)

Li, Wu; Padula, Sharon L.

2003-01-01

The robust airfoil shape optimization is a direct method for drag reduction over a given range of operating conditions and has three advantages: (1) it prevents severe degradation in the off-design performance by using a smart descent direction in each optimization iteration, (2) it uses a large number of B-spline control points as design variables yet the resulting airfoil shape is fairly smooth, and (3) it allows the user to make a trade-off between the level of optimization and the amount of computing time consumed. The robust optimization method is demonstrated by solving a lift-constrained drag minimization problem for a two-dimensional airfoil in viscous flow with a large number of geometric design variables. Our experience with robust optimization indicates that our strategy produces reasonable airfoil shapes that are similar to the original airfoils, but these new shapes provide drag reduction over the specified range of Mach numbers. We have tested this strategy on a number of advanced airfoil models produced by knowledgeable aerodynamic design team members and found that our strategy produces airfoils better or equal to any designs produced by traditional design methods.

A novel high-throughput (HTP) cloning strategy for site-directed designed chimeragenesis and mutation using the Gateway cloning system

PubMed Central

Suzuki, Yasuhiro; Kagawa, Naoko; Fujino, Toru; Sumiya, Tsuyoshi; Andoh, Taichi; Ishikawa, Kumiko; Kimura, Rie; Kemmochi, Kiyokazu; Ohta, Tsutomu; Tanaka, Shigeo

2005-01-01

There is an increasing demand for easy, high-throughput (HTP) methods for protein engineering to support advances in the development of structural biology, bioinformatics and drug design. Here, we describe an N- and C-terminal cloning method utilizing Gateway cloning technology that we have adopted for chimeric and mutant genes production as well as domain shuffling. This method involves only three steps: PCR, in vitro recombination and transformation. All three processes consist of simple handling, mixing and incubation steps. We have characterized this novel HTP method on 96 targets with >90% success. Here, we also discuss an N- and C-terminal cloning method for domain shuffling and a combination of mutation and chimeragenesis with two types of plasmid vectors. PMID:16009811

Intermediate/Advanced Research Design and Statistics

NASA Technical Reports Server (NTRS)

Ploutz-Snyder, Robert

2009-01-01

The purpose of this module is To provide Institutional Researchers (IRs) with an understanding of the principles of advanced research design and the intermediate/advanced statistical procedures consistent with such designs

Analysis and Design of Rotors at Ultra-Low Reynolds Numbers

NASA Technical Reports Server (NTRS)

Kunz, Peter J.; Strawn, Roger C.

2003-01-01

Design tools have been developed for ultra-low Reynolds number rotors, combining enhanced actuator-ring / blade-element theory with airfoil section data based on two-dimensional Navier-Stokes calculations. This performance prediction method is coupled with an optimizer for both design and analysis applications. Performance predictions from these tools have been compared with three-dimensional Navier Stokes analyses and experimental data for a 2.5 cm diameter rotor with chord Reynolds numbers below 10,000. Comparisons among the analyses and experimental data show reasonable agreement both in the global thrust and power required, but the spanwise distributions of these quantities exhibit significant deviations. The study also reveals that three-dimensional and rotational effects significantly change local airfoil section performance. The magnitude of this issue, unique to this operating regime, may limit the applicability of blade-element type methods for detailed rotor design at ultra-low Reynolds numbers, but these methods are still useful for evaluating concept feasibility and rapidly generating initial designs for further analysis and optimization using more advanced tools.

Principles of Protein Stability and Their Application in Computational Design.

PubMed

Goldenzweig, Adi; Fleishman, Sarel

2018-01-26

Proteins are increasingly used in basic and applied biomedical research.Many proteins, however, are only marginally stable and can be expressed in limited amounts, thus hampering research and applications. Research has revealed the thermodynamic, cellular, and evolutionary principles and mechanisms that underlie marginal stability. With this growing understanding, computational stability design methods have advanced over the past two decades starting from methods that selectively addressed only some aspects of marginal stability. Current methods are more general and, by combining phylogenetic analysis with atomistic design, have shown drastic improvements in solubility, thermal stability, and aggregation resistance while maintaining the protein's primary molecular activity. Stability design is opening the way to rational engineering of improved enzymes, therapeutics, and vaccines and to the application of protein design methodology to large proteins and molecular activities that have proven challenging in the past. Expected final online publication date for the Annual Review of Biochemistry Volume 87 is June 20, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Transforming consumer health informatics through a patient work framework: connecting patients to context

PubMed Central

Valdez, Rupa S; Holden, Richard J; Novak, Laurie L; Veinot, Tiffany C

2015-01-01

Designing patient-centered consumer health informatics (CHI) applications requires understanding and creating alignment with patients’ and their family members’ health-related activities, referred to here as ‘patient work’. A patient work approach to CHI draws on medical social science and human factors engineering models and simultaneously attends to patients, their family members, activities, and context. A patient work approach extends existing approaches to CHI design that are responsive to patients’ biomedical realities and personal skills and behaviors. It focuses on the embeddedness of patients’ health management in larger processes and contexts and prioritizes patients’ perspectives on illness management. Future research is required to advance (1) theories of patient work, (2) methods for assessing patient work, and (3) techniques for translating knowledge of patient work into CHI application design. Advancing a patient work approach within CHI is integral to developing and deploying consumer-facing technologies that are integrated with patients’ everyday lives. PMID:25125685

Designing Radiation Resistance in Materials for Fusion Energy

NASA Astrophysics Data System (ADS)

Zinkle, S. J.; Snead, L. L.

2014-07-01

Proposed fusion and advanced (Generation IV) fission energy systems require high-performance materials capable of satisfactory operation up to neutron damage levels approaching 200 atomic displacements per atom with large amounts of transmutant hydrogen and helium isotopes. After a brief overview of fusion reactor concepts and radiation effects phenomena in structural and functional (nonstructural) materials, three fundamental options for designing radiation resistance are outlined: Utilize matrix phases with inherent radiation tolerance, select materials in which vacancies are immobile at the design operating temperatures, or engineer materials with high sink densities for point defect recombination. Environmental and safety considerations impose several additional restrictions on potential materials systems, but reduced-activation ferritic/martensitic steels (including thermomechanically treated and oxide dispersion-strengthened options) and silicon carbide ceramic composites emerge as robust structural materials options. Materials modeling (including computational thermodynamics) and advanced manufacturing methods are poised to exert a major impact in the next ten years.

ADGS-2100 Adaptive Display and Guidance System Window Manager Analysis

NASA Technical Reports Server (NTRS)

Whalen, Mike W.; Innis, John D.; Miller, Steven P.; Wagner, Lucas G.

2006-01-01

Recent advances in modeling languages have made it feasible to formally specify and analyze the behavior of large system components. Synchronous data flow languages, such as Lustre, SCR, and RSML-e are particularly well suited to this task, and commercial versions of these tools such as SCADE and Simulink are growing in popularity among designers of safety critical systems, largely due to their ability to automatically generate code from the models. At the same time, advances in formal analysis tools have made it practical to formally verify important properties of these models to ensure that design defects are identified and corrected early in the lifecycle. This report describes how these tools have been applied to the ADGS-2100 Adaptive Display and Guidance Window Manager being developed by Rockwell Collins Inc. This work demonstrates how formal methods can be easily and cost-efficiently used to remove defects early in the design cycle.

Computers and the design of ion beam optical systems

NASA Astrophysics Data System (ADS)

White, Nicholas R.

Advances in microcomputers have made it possible to maintain a library of advanced ion optical programs which can be used on inexpensive computer hardware, which are suitable for the design of a variety of ion beam systems including ion implanters, giving excellent results. This paper describes in outline the steps typically involved in designing a complete ion beam system for materials modification applications. Two computer programs are described which, although based largely on algorithms which have been in use for many years, make possible detailed beam optical calculations using microcomputers, specifically the IBM PC. OPTICIAN is an interactive first-order program for tracing beam envelopes through complex optical systems. SORCERY is a versatile program for solving Laplace's and Poisson's equations by finite difference methods using successive over-relaxation. Ion and electron trajectories can be traced through these potential fields, and plots of beam emittance obtained.

Grid-connected in-stream hydroelectric generation based on the doubly fed induction machine

NASA Astrophysics Data System (ADS)

Lenberg, Timothy J.

Within the United States, there is a growing demand for new environmentally friendly power generation. This has led to a surge in wind turbine development. Unfortunately, wind is not a stable prime mover, but water is. Why not apply the advances made for wind to in-stream hydroelectric generation? One important advancement is the creation of the Doubly Fed Induction Machine (DFIM). This thesis covers the application of a gearless DFIM topology for hydrokinetic generation. After providing background, this thesis presents many of the options available for the mechanical portion of the design. A mechanical turbine is then specified. Next, a method is presented for designing a DFIM including the actual design for this application. In Chapter 4, a simulation model of the system is presented, complete with a control system that maximizes power generation based on water speed. This section then goes on to present simulation results demonstrating proper operation.

Computational Fluid Dynamics of Whole-Body Aircraft

NASA Astrophysics Data System (ADS)

Agarwal, Ramesh

1999-01-01

The current state of the art in computational aerodynamics for whole-body aircraft flowfield simulations is described. Recent advances in geometry modeling, surface and volume grid generation, and flow simulation algorithms have led to accurate flowfield predictions for increasingly complex and realistic configurations. As a result, computational aerodynamics has emerged as a crucial enabling technology for the design and development of flight vehicles. Examples illustrating the current capability for the prediction of transport and fighter aircraft flowfields are presented. Unfortunately, accurate modeling of turbulence remains a major difficulty in the analysis of viscosity-dominated flows. In the future, inverse design methods, multidisciplinary design optimization methods, artificial intelligence technology, and massively parallel computer technology will be incorporated into computational aerodynamics, opening up greater opportunities for improved product design at substantially reduced costs.

Develop applications based on android: Teacher Engagement Control of Health (TECH)

NASA Astrophysics Data System (ADS)

Sasmoko; Manalu, S. R.; Widhoyoko, S. A.; Indrianti, Y.; Suparto

2018-03-01

Physical and psychological condition of teachers is very important because it helped determine the realization of a positive school climate and productive so that they can run their profession optimally. This research is an advanced research on the design of ITEI application that able to see the profile of teacher’s engagement in Indonesia and to optimize the condition is needed an application that can detect the health of teachers both physically and psychologically. The research method used is the neuroresearch method combined with the development of IT system design for TECH which includes server design, database and android TECH application display. The study yielded 1) mental health benchmarks, 2) physical health benchmarks, and 3) the design of Android Application for Teacher Engagement Control of Health (TECH).

Broadening the Scope of Dental Education.

ERIC Educational Resources Information Center

Loe, Harald

1992-01-01

Scientific and technological advances affecting dental education in the near future are examined, including the growing role of saliva in diagnosis, direct imaging methods, biomaterials research, computer-aided design and manufacturing, molecular biology, and new restorative dentistry. It is argued that dentistry should be a fully recognized…

Social and Environmental Justice in the Chemistry Classroom

ERIC Educational Resources Information Center

Lasker, Grace A.; Mellor, Karolina E.; Mullins, Melissa L.; Nesmith, Suzanne M.; Simcox, Nancy J.

2017-01-01

Despite advances in active learning pedagogy and other methods designed to increase student engagement in the chemistry classroom, retention and engagement issues still persist, particularly with respect to women and minorities underrepresented in STEM (science, technology, engineering, and mathematics) programs. Relevancy also remains elusive in…

Preliminary measurement of the noise from the 2/9 scale model of the Large-scale Advanced Propfan (LAP) propeller, SR-7A

NASA Technical Reports Server (NTRS)

Dittmar, J. H.

1985-01-01

Noise data on the Large-scale Advanced Propfan (LAP) propeller model SR-7A were taken into the NASA Lewis 8- by 6-Foot Wind Tunnel. The maximum blade passing tone decreases from the peak level when going to higher helical tip Mach numbers. This noise reduction points to the use of higher propeller speeds as a possible method to reduce airplane cabin noise while maintaining high flight speed and efficiency. Comparison of the SR-7A blade passing noise with the noise of the similarly designed SR-3 propeller shows good agreement as expected. The SR-7A propeller is slightly noisier than the SR-3 model in the plane of rotation at the cruise condition. Projections of the tunnel model data are made to the full-scale LAP propeller mounted on the test bed aircraft and compared with design predictions. The prediction method is conservative in the sense that it overpredicts the projected model data.

VIII. THE PAST, PRESENT, AND FUTURE OF DEVELOPMENTAL METHODOLOGY.

PubMed

Little, Todd D; Wang, Eugene W; Gorrall, Britt K

2017-06-01

This chapter selectively reviews the evolution of quantitative practices in the field of developmental methodology. The chapter begins with an overview of the past in developmental methodology, discussing the implementation and dissemination of latent variable modeling and, in particular, longitudinal structural equation modeling. It then turns to the present state of developmental methodology, highlighting current methodological advances in the field. Additionally, this section summarizes ample quantitative resources, ranging from key quantitative methods journal articles to the various quantitative methods training programs and institutes. The chapter concludes with the future of developmental methodology and puts forth seven future innovations in the field. The innovations discussed span the topics of measurement, modeling, temporal design, and planned missing data designs. Lastly, the chapter closes with a brief overview of advanced modeling techniques such as continuous time models, state space models, and the application of Bayesian estimation in the field of developmental methodology. © 2017 The Society for Research in Child Development, Inc.

Methods of alleviation of ionospheric scintillation effects on digital communications

NASA Technical Reports Server (NTRS)

Massey, J. L.

1974-01-01

The degradation of the performance of digital communication systems because of ionospheric scintillation effects can be reduced either by diversity techniques or by coding. The effectiveness of traditional space-diversity, frequency-diversity and time-diversity techniques is reviewed and design considerations isolated. Time-diversity signaling is then treated as an extremely simple form of coding. More advanced coding methods, such as diffuse threshold decoding and burst-trapping decoding, which appear attractive in combatting scintillation effects are discussed and design considerations noted. Finally, adaptive coding techniques appropriate when the general state of the channel is known are discussed.

Advancing Collaboration between School- and Agency-Employed School-Based Social Workers: A Mixed-Methods Comparison of Competencies and Preparedness

ERIC Educational Resources Information Center

Bronstein, Laura R.; Ball, Annahita; Mellin, Elizabeth A.; Wade-Mdivanian, Rebecca; Anderson-Butcher, Dawn

2011-01-01

The purpose of this article is to share results of a mixed-methods research study designed to shed light on similarities and differences between school-employed and agency-employed school-based social workers' preparation and practice as a precursor for collaboration in expanded school mental health. Online survey data from a national sample of…

Integrated heat exchanger design for a cryogenic storage tank

NASA Astrophysics Data System (ADS)

Fesmire, J. E.; Tomsik, T. M.; Bonner, T.; Oliveira, J. M.; Conyers, H. J.; Johnson, W. L.; Notardonato, W. U.

2014-01-01

Field demonstrations of liquid hydrogen technology will be undertaken for the proliferation of advanced methods and applications in the use of cryofuels. Advancements in the use of cryofuels for transportation on Earth, from Earth, or in space are envisioned for automobiles, aircraft, rockets, and spacecraft. These advancements rely on practical ways of storage, transfer, and handling of liquid hydrogen. Focusing on storage, an integrated heat exchanger system has been designed for incorporation with an existing storage tank and a reverse Brayton cycle helium refrigerator of capacity 850 watts at 20 K. The storage tank is a 125,000-liter capacity horizontal cylindrical tank, with vacuum jacket and multilayer insulation, and a small 0.6-meter diameter manway opening. Addressed are the specific design challenges associated with the small opening, complete modularity, pressure systems re-certification for lower temperature and pressure service associated with hydrogen densification, and a large 8:1 length-to-diameter ratio for distribution of the cryogenic refrigeration. The approach, problem solving, and system design and analysis for integrated heat exchanger are detailed and discussed. Implications for future space launch facilities are also identified. The objective of the field demonstration will be to test various zero-loss and densified cryofuel handling concepts for future transportation applications.

Integrated heat exchanger design for a cryogenic storage tank

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fesmire, J. E.; Bonner, T.; Oliveira, J. M.

Field demonstrations of liquid hydrogen technology will be undertaken for the proliferation of advanced methods and applications in the use of cryofuels. Advancements in the use of cryofuels for transportation on Earth, from Earth, or in space are envisioned for automobiles, aircraft, rockets, and spacecraft. These advancements rely on practical ways of storage, transfer, and handling of liquid hydrogen. Focusing on storage, an integrated heat exchanger system has been designed for incorporation with an existing storage tank and a reverse Brayton cycle helium refrigerator of capacity 850 watts at 20 K. The storage tank is a 125,000-liter capacity horizontal cylindricalmore » tank, with vacuum jacket and multilayer insulation, and a small 0.6-meter diameter manway opening. Addressed are the specific design challenges associated with the small opening, complete modularity, pressure systems re-certification for lower temperature and pressure service associated with hydrogen densification, and a large 8:1 length-to-diameter ratio for distribution of the cryogenic refrigeration. The approach, problem solving, and system design and analysis for integrated heat exchanger are detailed and discussed. Implications for future space launch facilities are also identified. The objective of the field demonstration will be to test various zero-loss and densified cryofuel handling concepts for future transportation applications.« less

Aerodynamic optimization studies on advanced architecture computers

NASA Technical Reports Server (NTRS)

Chawla, Kalpana

1995-01-01

The approach to carrying out multi-discipline aerospace design studies in the future, especially in massively parallel computing environments, comprises of choosing (1) suitable solvers to compute solutions to equations characterizing a discipline, and (2) efficient optimization methods. In addition, for aerodynamic optimization problems, (3) smart methodologies must be selected to modify the surface shape. In this research effort, a 'direct' optimization method is implemented on the Cray C-90 to improve aerodynamic design. It is coupled with an existing implicit Navier-Stokes solver, OVERFLOW, to compute flow solutions. The optimization method is chosen such that it can accomodate multi-discipline optimization in future computations. In the work , however, only single discipline aerodynamic optimization will be included.

FFTF Passive Safety Test Data for Benchmarks for New LMR Designs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wootan, David W.; Casella, Andrew M.

Liquid Metal Reactors (LMRs) continue to be considered as an attractive concept for advanced reactor design. Software packages such as SASSYS are being used to im-prove new LMR designs and operating characteristics. Significant cost and safety im-provements can be realized in advanced liquid metal reactor designs by emphasizing inherent or passive safety through crediting the beneficial reactivity feedbacks associ-ated with core and structural movement. This passive safety approach was adopted for the Fast Flux Test Facility (FFTF), and an experimental program was conducted to characterize the structural reactivity feedback. The FFTF passive safety testing pro-gram was developed to examine howmore » specific design elements influenced dynamic re-activity feedback in response to a reactivity input and to demonstrate the scalability of reactivity feedback results to reactors of current interest. The U.S. Department of En-ergy, Office of Nuclear Energy Advanced Reactor Technology program is in the pro-cess of preserving, protecting, securing, and placing in electronic format information and data from the FFTF, including the core configurations and data collected during the passive safety tests. Benchmarks based on empirical data gathered during operation of the Fast Flux Test Facility (FFTF) as well as design documents and post-irradiation examination will aid in the validation of these software packages and the models and calculations they produce. Evaluation of these actual test data could provide insight to improve analytical methods which may be used to support future licensing applications for LMRs« less

Multidisciplinary Design Techniques Applied to Conceptual Aerospace Vehicle Design. Ph.D. Thesis Final Technical Report

NASA Technical Reports Server (NTRS)

Olds, John Robert; Walberg, Gerald D.

1993-01-01

Multidisciplinary design optimization (MDO) is an emerging discipline within aerospace engineering. Its goal is to bring structure and efficiency to the complex design process associated with advanced aerospace launch vehicles. Aerospace vehicles generally require input from a variety of traditional aerospace disciplines - aerodynamics, structures, performance, etc. As such, traditional optimization methods cannot always be applied. Several multidisciplinary techniques and methods were proposed as potentially applicable to this class of design problem. Among the candidate options are calculus-based (or gradient-based) optimization schemes and parametric schemes based on design of experiments theory. A brief overview of several applicable multidisciplinary design optimization methods is included. Methods from the calculus-based class and the parametric class are reviewed, but the research application reported focuses on methods from the parametric class. A vehicle of current interest was chosen as a test application for this research. The rocket-based combined-cycle (RBCC) single-stage-to-orbit (SSTO) launch vehicle combines elements of rocket and airbreathing propulsion in an attempt to produce an attractive option for launching medium sized payloads into low earth orbit. The RBCC SSTO presents a particularly difficult problem for traditional one-variable-at-a-time optimization methods because of the lack of an adequate experience base and the highly coupled nature of the design variables. MDO, however, with it's structured approach to design, is well suited to this problem. The result of the application of Taguchi methods, central composite designs, and response surface methods to the design optimization of the RBCC SSTO are presented. Attention is given to the aspect of Taguchi methods that attempts to locate a 'robust' design - that is, a design that is least sensitive to uncontrollable influences on the design. Near-optimum minimum dry weight solutions are determined for the vehicle. A summary and evaluation of the various parametric MDO methods employed in the research are included. Recommendations for additional research are provided.

Accoustic waveform logging--Advances in theory and application

USGS Publications Warehouse

Paillet, F.L.; Cheng, C.H.; Pennington , W.D.

1992-01-01

Full-waveform acoustic logging has made significant advances in both theory and application in recent years, and these advances have greatly increased the capability of log analysts to measure the physical properties of formations. Advances in theory provide the analytical tools required to understand the properties of measured seismic waves, and to relate those properties to such quantities as shear and compressional velocity and attenuation, and primary and fracture porosity and permeability of potential reservoir rocks. The theory demonstrates that all parts of recorded waveforms are related to various modes of propagation, even in the case of dipole and quadrupole source logging. However, the theory also indicates that these mode properties can be used to design velocity and attenuation picking schemes, and shows how source frequency spectra can be selected to optimize results in specific applications. Synthetic microseismogram computations are an effective tool in waveform interpretation theory; they demonstrate how shear arrival picks and mode attenuation can be used to compute shear velocity and intrinsic attenuation, and formation permeability for monopole, dipole and quadrupole sources. Array processing of multi-receiver data offers the opportunity to apply even more sophisticated analysis techniques. Synthetic microseismogram data is used to illustrate the application of the maximum-likelihood method, semblance cross-correlation, and Prony's method analysis techniques to determine seismic velocities and attenuations. The interpretation of acoustic waveform logs is illustrated by reviews of various practical applications, including synthetic seismogram generation, lithology determination, estimation of geomechanical properties in situ, permeability estimation, and design of hydraulic fracture operations.

Reduced toxicity polyester resins and microvascular pre-preg tapes for advanced composites manufacturing

NASA Astrophysics Data System (ADS)

Poillucci, Richard

Advanced composites manufacturing broadly encapsulates topics ranging from matrix chemistries to automated machines that lay-up fiber-reinforced materials. Environmental regulations are stimulating research to reduce matrix resin formulation toxicity. At present, composites fabricated with polyester resins expose workers to the risk of contact with and inhalation of styrene monomer, which is a potential carcinogen, neurotoxin, and respiratory irritant. The first primary goal of this thesis is to reduce the toxicity associated with polyester resins by: (1) identification of potential monomers to replace styrene, (2) determination of monomer solubility within the polyester, and (3) investigation of approaches to rapidly screen a large resin composition parameter space. Monomers are identified based on their ability to react with polyester and their toxicity as determined by the Globally Harmonized System (GHS) and a green screen method. Solubilities were determined by the Hoftyzer -- Van Krevelen method, Hansen solubility parameter database, and experimental mixing of monomers. A combinatorial microfluidic mixing device is designed and tested to obtain distinct resin compositions from two input chemistries. The push for safer materials is complemented by a thrust for multifunctional composites. The second primary goal of this thesis is to design and implement the manufacture of sacrificial fiber materials suitable for use in automated fiber placement of microvascaular multifunctional composites. Two key advancements are required to achieve this goal: (1) development of a roll-to-roll method to place sacrificial fibers onto carbon fiber pre-preg tape; and (2) demonstration of feasible manufacture of microvascular carbon fiber plates with automated fiber placement. An automated method for placing sacrificial fibers onto carbon fiber tapes is designed and a prototype implemented. Carbon fiber tows with manual placement of sacrificial fibers is implemented within an automated fiber placement machine and the successful fabrication of a carbon fiber plate with an integrated microvascular channel is demonstrated.

Computational methods to extract meaning from text and advance theories of human cognition.

PubMed

McNamara, Danielle S

2011-01-01

Over the past two decades, researchers have made great advances in the area of computational methods for extracting meaning from text. This research has to a large extent been spurred by the development of latent semantic analysis (LSA), a method for extracting and representing the meaning of words using statistical computations applied to large corpora of text. Since the advent of LSA, researchers have developed and tested alternative statistical methods designed to detect and analyze meaning in text corpora. This research exemplifies how statistical models of semantics play an important role in our understanding of cognition and contribute to the field of cognitive science. Importantly, these models afford large-scale representations of human knowledge and allow researchers to explore various questions regarding knowledge, discourse processing, text comprehension, and language. This topic includes the latest progress by the leading researchers in the endeavor to go beyond LSA. Copyright © 2010 Cognitive Science Society, Inc.

[An Introduction to Methods for Evaluating Health Care Technology].

PubMed

Lee, Ting-Ting

2015-06-01

The rapid and continual advance of healthcare technology makes ensuring that this technology is used effectively to achieve its original goals a critical issue. This paper presents three methods that may be applied by healthcare professionals in the evaluation of healthcare technology. These methods include: the perception/experiences of users, user work-pattern changes, and chart review or data mining. The first method includes two categories: using interviews to explore the user experience and using theory-based questionnaire surveys. The second method applies work sampling to observe the work pattern changes of users. The last method conducts chart reviews or data mining to analyze the designated variables. In conclusion, while evaluative feedback may be used to improve the design and development of healthcare technology applications, the informatics competency and informatics literacy of users may be further explored in future research.

GneimoSim: A Modular Internal Coordinates Molecular Dynamics Simulation Package

PubMed Central

Larsen, Adrien B.; Wagner, Jeffrey R.; Kandel, Saugat; Salomon-Ferrer, Romelia; Vaidehi, Nagarajan; Jain, Abhinandan

2014-01-01

The Generalized Newton Euler Inverse Mass Operator (GNEIMO) method is an advanced method for internal coordinates molecular dynamics (ICMD). GNEIMO includes several theoretical and algorithmic advancements that address longstanding challenges with ICMD simulations. In this paper we describe the GneimoSim ICMD software package that implements the GNEIMO method. We believe that GneimoSim is the first software package to include advanced features such as the equipartition principle derived for internal coordinates, and a method for including the Fixman potential to eliminate systematic statistical biases introduced by the use of hard constraints. Moreover, by design, GneimoSim is extensible and can be easily interfaced with third party force field packages for ICMD simulations. Currently, GneimoSim includes interfaces to LAMMPS, OpenMM, Rosetta force field calculation packages. The availability of a comprehensive Python interface to the underlying C++ classes and their methods provides a powerful and versatile mechanism for users to develop simulation scripts to configure the simulation and control the simulation flow. GneimoSim has been used extensively for studying the dynamics of protein structures, refinement of protein homology models, and for simulating large scale protein conformational changes with enhanced sampling methods. GneimoSim is not limited to proteins and can also be used for the simulation of polymeric materials. PMID:25263538

GneimoSim: a modular internal coordinates molecular dynamics simulation package.

PubMed

Larsen, Adrien B; Wagner, Jeffrey R; Kandel, Saugat; Salomon-Ferrer, Romelia; Vaidehi, Nagarajan; Jain, Abhinandan

2014-12-05

The generalized Newton-Euler inverse mass operator (GNEIMO) method is an advanced method for internal coordinates molecular dynamics (ICMD). GNEIMO includes several theoretical and algorithmic advancements that address longstanding challenges with ICMD simulations. In this article, we describe the GneimoSim ICMD software package that implements the GNEIMO method. We believe that GneimoSim is the first software package to include advanced features such as the equipartition principle derived for internal coordinates, and a method for including the Fixman potential to eliminate systematic statistical biases introduced by the use of hard constraints. Moreover, by design, GneimoSim is extensible and can be easily interfaced with third party force field packages for ICMD simulations. Currently, GneimoSim includes interfaces to LAMMPS, OpenMM, and Rosetta force field calculation packages. The availability of a comprehensive Python interface to the underlying C++ classes and their methods provides a powerful and versatile mechanism for users to develop simulation scripts to configure the simulation and control the simulation flow. GneimoSim has been used extensively for studying the dynamics of protein structures, refinement of protein homology models, and for simulating large scale protein conformational changes with enhanced sampling methods. GneimoSim is not limited to proteins and can also be used for the simulation of polymeric materials. © 2014 Wiley Periodicals, Inc.

A novel method for NDT applications using NXCT system at the Missouri University of Science & Technology

NASA Astrophysics Data System (ADS)

Sinha, Vaibhav; Srivastava, Anjali; Koo Lee, Hyoung

2014-06-01

A novel method for non-destructive analysis has been developed using a neutron/X-ray combined computed tomography (NXCT) system at the Missouri University of Science and Technology Reactor (MSTR). This imaging system takes advantage of the fact that neutrons and X-rays have characteristically different interactions with same materials. NXCT fuses the imaging capabilities of both systems at one location and allows instant evaluation for nondestructive testing (NDT) applications. This technique promises viable advances in the field of NDT. In this paper, the complete design criteria and procedures are provided. The described design criteria and procedures can effectively be utilized to design and develop advanced combined computed tomography system. The successful operation of the high resolution X-ray and neutron computed tomography has been demonstrated in this paper. The utility and importance of the NXCT system has been shown by nondestructive evaluation of various phantoms constituting different materials, geometrical, structural and compositional information. The concept of NXCT can be useful for concealed material detection, material characterization, investigation of complex geometries involving different atomic number materials and real time imaging for in-situ studies.

Multi-linear model set design based on the nonlinearity measure and H-gap metric.

PubMed

Shaghaghi, Davood; Fatehi, Alireza; Khaki-Sedigh, Ali

2017-05-01

This paper proposes a model bank selection method for a large class of nonlinear systems with wide operating ranges. In particular, nonlinearity measure and H-gap metric are used to provide an effective algorithm to design a model bank for the system. Then, the proposed model bank is accompanied with model predictive controllers to design a high performance advanced process controller. The advantage of this method is the reduction of excessive switch between models and also decrement of the computational complexity in the controller bank that can lead to performance improvement of the control system. The effectiveness of the method is verified by simulations as well as experimental studies on a pH neutralization laboratory apparatus which confirms the efficiency of the proposed algorithm. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

ADVANCED SEISMIC BASE ISOLATION METHODS FOR MODULAR REACTORS

DOE Office of Scientific and Technical Information (OSTI.GOV)

E. Blanford; E. Keldrauk; M. Laufer

2010-09-20

Advanced technologies for structural design and construction have the potential for major impact not only on nuclear power plant construction time and cost, but also on the design process and on the safety, security and reliability of next generation of nuclear power plants. In future Generation IV (Gen IV) reactors, structural and seismic design should be much more closely integrated with the design of nuclear and industrial safety systems, physical security systems, and international safeguards systems. Overall reliability will be increased, through the use of replaceable and modular equipment, and through design to facilitate on-line monitoring, in-service inspection, maintenance, replacement,more » and decommissioning. Economics will also receive high design priority, through integrated engineering efforts to optimize building arrangements to minimize building heights and footprints. Finally, the licensing approach will be transformed by becoming increasingly performance based and technology neutral, using best-estimate simulation methods with uncertainty and margin quantification. In this context, two structural engineering technologies, seismic base isolation and modular steel-plate/concrete composite structural walls, are investigated. These technologies have major potential to (1) enable standardized reactor designs to be deployed across a wider range of sites, (2) reduce the impact of uncertainties related to site-specific seismic conditions, and (3) alleviate reactor equipment qualification requirements. For Gen IV reactors the potential for deliberate crashes of large aircraft must also be considered in design. This report concludes that base-isolated structures should be decoupled from the reactor external event exclusion system. As an example, a scoping analysis is performed for a rectangular, decoupled external event shell designed as a grillage. This report also reviews modular construction technology, particularly steel-plate/concrete construction using factory prefabricated structural modules, for application to external event shell and base isolated structures.« less

Storyboarding: A Concrete Way to Generate Effective Visuals.

ERIC Educational Resources Information Center

Larkin, Greg

1996-01-01

Advances the idea that storyboarding, long associated with scriptwriting, advertising, and more recently with technical manuals, can be successfully applied to an even broader variety of technical documents. Applies storyboarding techniques to designing technical proposals to suggest methods of incorporating more visuals into documents, as well as…

ADVANCED URBANIZED METEOROLOGICAL MODELING AND AIR QUALITY SIMULATIONS WITH CMAQ AT NEIGHBORHOOD SCALES

EPA Science Inventory

We present results from a study testing the new boundary layer parameterization method, the canopy drag approach (DA) which is designed to explicitly simulate the effects of buildings, street and tree canopies on the dynamic, thermodynamic structure and dispersion fields in urban...

The Web-Driven Learning Ecosystem: Its Structure and Benefits

ERIC Educational Resources Information Center

Raska, David; Shaw, Doris; Keller, Eileen Weisenbach

2012-01-01

We have devised a Web-based learning ecosystem (LECOS) that aligns marketing curriculum, course design, technology, instructors, students, as well as external stakeholders--a system that integrates traditional teaching methods with technological advancements in an attempt to enhance marketing students' motivation, engagement, and performance. A…

Propeller dynamic and aeroelastic effects

NASA Technical Reports Server (NTRS)

Mccormick, B. W.

1980-01-01

Various aspects of propeller blade dynamics are considered including those factors which are exciting the blades and the dynamic response of the blades to the excitations. Methods for treating this dynamic system are described and problems are discussed which may arise with advanced turboprop designs employing thin, swept blades.

DNA nanotechnology: Bringing lipid bilayers into shape

NASA Astrophysics Data System (ADS)

Howorka, Stefan

2017-07-01

Lipid bilayers form the thin and floppy membranes that define the boundary of compartments such as cells. Now, a method to control the shape and size of bilayers using DNA nanoscaffolds has been developed. Such designer materials advance synthetic biology and could find use in membrane research.

West German Biotech Institute Trains Third World Scientists.

ERIC Educational Resources Information Center

O'Sullivan, Dermot A.

1987-01-01

Describes a six-week program designed to give scientists from developing countries advanced training in biotechnology methods. Stresses the need to provide the participants with "hands-on" experiences to enhance their ability to contribute to biotechnology programs in their home countries and to train others locally. (TW)

Rigorous ILT optimization for advanced patterning and design-process co-optimization

NASA Astrophysics Data System (ADS)

Selinidis, Kosta; Kuechler, Bernd; Cai, Howard; Braam, Kyle; Hoppe, Wolfgang; Domnenko, Vitaly; Poonawala, Amyn; Xiao, Guangming

2018-03-01

Despite the large difficulties involved in extending 193i multiple patterning and the slow ramp of EUV lithography to full manufacturing readiness, the pace of development for new technology node variations has been accelerating. Multiple new variations of new and existing technology nodes have been introduced for a range of device applications; each variation with at least a few new process integration methods, layout constructs and/or design rules. This had led to a strong increase in the demand for predictive technology tools which can be used to quickly guide important patterning and design co-optimization decisions. In this paper, we introduce a novel hybrid predictive patterning method combining two patterning technologies which have each individually been widely used for process tuning, mask correction and process-design cooptimization. These technologies are rigorous lithography simulation and inverse lithography technology (ILT). Rigorous lithography simulation has been extensively used for process development/tuning, lithography tool user setup, photoresist hot-spot detection, photoresist-etch interaction analysis, lithography-TCAD interactions/sensitivities, source optimization and basic lithography design rule exploration. ILT has been extensively used in a range of lithographic areas including logic hot-spot fixing, memory layout correction, dense memory cell optimization, assist feature (AF) optimization, source optimization, complex patterning design rules and design-technology co-optimization (DTCO). The combined optimization capability of these two technologies will therefore have a wide range of useful applications. We investigate the benefits of the new functionality for a few of these advanced applications including correction for photoresist top loss and resist scumming hotspots.

The application of artificial intelligence technology to aeronautical system design

NASA Technical Reports Server (NTRS)

Bouchard, E. E.; Kidwell, G. H.; Rogan, J. E.

1988-01-01

This paper describes the automation of one class of aeronautical design activity using artificial intelligence and advanced software techniques. Its purpose is to suggest concepts, terminology, and approaches that may be useful in enhancing design automation. By understanding the basic concepts and tasks in design, and the technologies that are available, it will be possible to produce, in the future, systems whose capabilities far exceed those of today's methods. Some of the tasks that will be discussed have already been automated and are in production use, resulting in significant productivity benefits. The concepts and techniques discussed are applicable to all design activity, though aeronautical applications are specifically presented.

Space construction system analysis. Part 2: Platform definition

NASA Technical Reports Server (NTRS)

Hart, R. J.; Myers, H. L.; Abramson, R. D.; Dejong, P. N.; Donavan, R. D.; Greenberg, H. S.; Indrikis, J.; Jandrasi, J. S.; Manoff, M.; Mcbaine, C. K.

1980-01-01

The top level system requirements are summarized and the accompanying conceptual design for an engineering and technology verification platform (ETVP) system is presented. An encompassing statement of the system objectives which drive the system requirements is presented and the major mission and subsystem requirements are described with emphasis on the advanced communications technology mission payload. The platform design is defined and used as a reference configuration for an end to space construction analyses. The preferred construction methods and processes, the important interactions between the platform design and the construction system design and operation, and the technology development efforts required to support the design and space construction of the ETVP are outlined.

Improving the Aircraft Design Process Using Web-Based Modeling and Simulation

NASA Technical Reports Server (NTRS)

Reed, John A.; Follen, Gregory J.; Afjeh, Abdollah A.; Follen, Gregory J. (Technical Monitor)

2000-01-01

Designing and developing new aircraft systems is time-consuming and expensive. Computational simulation is a promising means for reducing design cycle times, but requires a flexible software environment capable of integrating advanced multidisciplinary and multifidelity analysis methods, dynamically managing data across heterogeneous computing platforms, and distributing computationally complex tasks. Web-based simulation, with its emphasis on collaborative composition of simulation models, distributed heterogeneous execution, and dynamic multimedia documentation, has the potential to meet these requirements. This paper outlines the current aircraft design process, highlighting its problems and complexities, and presents our vision of an aircraft design process using Web-based modeling and simulation.

Improving the Aircraft Design Process Using Web-based Modeling and Simulation

NASA Technical Reports Server (NTRS)

Reed, John A.; Follen, Gregory J.; Afjeh, Abdollah A.

2003-01-01

Designing and developing new aircraft systems is time-consuming and expensive. Computational simulation is a promising means for reducing design cycle times, but requires a flexible software environment capable of integrating advanced multidisciplinary and muitifidelity analysis methods, dynamically managing data across heterogeneous computing platforms, and distributing computationally complex tasks. Web-based simulation, with its emphasis on collaborative composition of simulation models, distributed heterogeneous execution, and dynamic multimedia documentation, has the potential to meet these requirements. This paper outlines the current aircraft design process, highlighting its problems and complexities, and presents our vision of an aircraft design process using Web-based modeling and simulation.

PREFACE: Trends in Aerospace Manufacturing 2009 International Conference

NASA Astrophysics Data System (ADS)

Ridgway, Keith; Gault, Rosemary; Allen, Adrian

2011-12-01

The aerospace industry is rapidly changing. New aircraft structures are being developed and aero-engines are becoming lighter and more environmentally friendly. In both areas, innovative materials and manufacturing methods are used in an attempt to get maximum performance for minimum cost. At the same time, the structure of the industry has changed and there has been a move from large companies designing, manufacturing components and assembling aircraft to one of large global supply chains headed by large system integrators. All these changes have forced engineers and managers to bring in innovations in design, materials, manufacturing technologies and supply chain management. In September 2009, the Advanced Manufacturing Research Centre (AMRC) at the University of Sheffield held the inaugural Trends in Aerospace Manufacturing conference (TRAM09). This brought together 28 speakers over two days, who presented in sessions on advanced manufacturing trends for the aerospace sector. Areas covered included new materials, including composites, advanced machining, state of the art additive manufacturing techniques, assembly and supply chain issues.

The advanced software development workstation project

NASA Technical Reports Server (NTRS)

Fridge, Ernest M., III; Pitman, Charles L.

1991-01-01

The Advanced Software Development Workstation (ASDW) task is researching and developing the technologies required to support Computer Aided Software Engineering (CASE) with the emphasis on those advanced methods, tools, and processes that will be of benefit to support all NASA programs. Immediate goals are to provide research and prototype tools that will increase productivity, in the near term, in projects such as the Software Support Environment (SSE), the Space Station Control Center (SSCC), and the Flight Analysis and Design System (FADS) which will be used to support the Space Shuttle and Space Station Freedom. Goals also include providing technology for development, evolution, maintenance, and operations. The technologies under research and development in the ASDW project are targeted to provide productivity enhancements during the software life cycle phase of enterprise and information system modeling, requirements generation and analysis, system design and coding, and system use and maintenance. On-line user's guides will assist users in operating the developed information system with knowledge base expert assistance.

Values and options in cancer care (VOICE): study design and rationale for a patient-centered communication and decision-making intervention for physicians, patients with advanced cancer, and their caregivers

PubMed Central

2013-01-01

Background Communication about prognosis and treatment choices is essential for informed decision making in advanced cancer. This article describes an investigation designed to facilitate communication and decision making among oncologists, patients with advanced cancer, and their caregivers. Methods/design The Values and Options in Cancer Care (VOICE) Study is a National Cancer Institute sponsored randomized controlled trial conducted in the Rochester/Buffalo, NY and Sacramento, CA regions. A total of 40 oncologists, approximately 400 patients with advanced cancer, and their family/friend caregivers (one per patient, when available) are expected to enroll in the study. Drawing upon ecological theory, the intervention uses a two-pronged approach: oncologists complete a multifaceted tailored educational intervention involving standardized patient instructors (SPIs), and patients and caregivers complete a coaching intervention to facilitate prioritizing and discussing questions and concerns. Follow-up data will be collected approximately quarterly for up to three years. Discussion The intervention is hypothesized to enhance patient-centered communication, quality of care, and patient outcomes. Analyses will examine the effects of the intervention on key elements of physician-patient-caregiver communication (primary outcomes), the physician-patient relationship, shared understanding of prognosis, patient well-being, and health service utilization (secondary outcomes). Trial registration Clinical Trials Identifier: NCT01485627 PMID:23570278

Research perspectives in first metatarsal osteotomy and fixation stability.

PubMed

Landsman, A S; Higgins, K R; Lampe, N

1996-07-01

Well-designated research is required to provide clinical guidance by validation of old and new methods. Variables, including technologic advancement in surgical techniques, diagnosis, shoe design, and immobilization all contribute to the challenge of investigating surgical procedures of the foot. This article highlights some of the relevant research pertaining to first metatarsal osteotomies and internal fixation and provides direction for potential, future research. Numerous aspects about the research techniques involved are discussed.

Geodesy and the UNAVCO Consortium: Three Decades of Innovations

NASA Astrophysics Data System (ADS)

Rowan, L. R.; Miller, M. M.; Meertens, C. M.; Mattioli, G. S.

2015-12-01

UNAVCO, a non-profit, university consortium that supports geoscience research using geodesy, began with the ingenious recognition that the nascent Global Positioning System constellation (GPS) could be used to investigate earth processes. The consortium purchased one of the first commercially available GPS receivers, Texas Instrument's TI-4100 NAVSTAR Navigator, in 1984 to measure plate deformation. This early work was highlighted in a technology magazine, GPSWorld, in 1990. Over a 30-year period, UNAVCO and the community have helped advance instrument design for mobility, flexibility, efficiency and interoperability, so research could proceed with higher precision and under ever challenging conditions. Other innovations have been made in data collection, processing, analysis, management and archiving. These innovations in tools, methods and data have had broader impacts as they have found greater utility beyond research for timing, precise positioning, safety, communication, navigation, surveying, engineering and recreation. Innovations in research have expanded the utility of geodetic tools beyond the solid earth science through creative analysis of the data and the methods. For example, GPS sounding of the atmosphere is now used for atmospheric and space sciences. GPS reflectrometry, another critical advance, supports soil science, snow science and ecological research. Some research advances have had broader impacts for society by driving innovations in hazards risk reduction, hazards response, resource management, land use planning, surveying, engineering and other uses. Furthermore, the geodetic data is vital for the design of space missions, testing and advancing communications, and testing and dealing with interference and GPS jamming. We will discuss three decades (and counting) of advances by the National Science Foundation's premiere geodetic facility, consortium and some of the many geoscience principal investigators that have driven innovations in research, instrumentation, data management, cyberinfrastructure and other applications.

Advancing the science of recruitment and retention of ethnically diverse populations.

PubMed

Nápoles, Anna M; Chadiha, Letha A

2011-06-01

We highlight several critical challenges that must be addressed to accelerate the advancement of the science on recruitment and retention of ethnically diverse older adults into health research. These include the relative lack of attention by researchers to methodological issues related to recruitment and retention of ethnically diverse populations and the inadequacy of funding to advance systematically this field. We describe strategies used by the Resource Centers on Minority Aging Research and other National Institute of Aging-funded programs to advance the science of recruitment of ethnically diverse older adults. Finally, we propose a set of broad recommendations designed to generate a body of evidence on successful methods of recruitment and retention of ethnically diverse populations in health research. To eliminate health disparities and better understand aging processes in ethnically diverse populations, much more research is needed on effective strategies for increasing minority enrollment in health research. Comparative effectiveness research on more intensive recruitment and retention methods, which are often needed for including diverse populations, will require dedicated funding and concerted efforts by investigators.

Chapter 16: Lignin Visualization: Advanced Microscopy Techniques for Lignin Characterization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zeng, Yining; Donohoe, Bryon S

Visualization of lignin in plant cell walls, with both spatial and chemical resolution, is emerging as an important tool to understand lignin's role in the plant cell wall's nanoscale architecture and to understand and design processes intended to modify the lignin. As such, this chapter reviews recent advances in advanced imaging methods with respect to lignin in plant cell walls. This review focuses on the importance of lignin detection and localization for studies in both plant biology and biotechnology. Challenges going forward to identify and delineate lignin from other plant cell wall components and to quantitatively analyze lignin in wholemore » cell walls from native plant tissue and treated biomass are also discussed.« less

The aerodynamic design of an advanced rotor airfoil

NASA Technical Reports Server (NTRS)

Blackwell, J. A., Jr.; Hinson, B. L.

1978-01-01

An advanced rotor airfoil, designed utilizing supercritical airfoil technology and advanced design and analysis methodology is described. The airfoil was designed subject to stringent aerodynamic design criteria for improving the performance over the entire rotor operating regime. The design criteria are discussed. The design was accomplished using a physical plane, viscous, transonic inverse design procedure, and a constrained function minimization technique for optimizing the airfoil leading edge shape. The aerodynamic performance objectives of the airfoil are discussed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hugo, Jacques Victor; Gertman, David Ira

The new generation of nuclear power plants (NPPs) will likely make use of state-of-the-art technologies in many areas of the plant. The analysis, design, and selection of advanced human–system interfaces (HSIs) constitute an important part of power plant engineering. Designers need to consider the new capabilities afforded by these technologies in the context of current regulations and new operational concepts, which is why they need a more rigorous method by which to plan the introduction of advanced HSIs in NPP work areas. Much of current human factors research stops at the user interface and fails to provide a definitive processmore » for integration of end user devices with instrumentation and control (I&C) and operational concepts. The current lack of a clear definition of HSI technology, including the process for integration, makes characterization and implementation of new and advanced HSIs difficult. This paper describes how new design concepts in the nuclear industry can be analyzed and how HSI technologies associated with new industrial processes might be considered. Furthermore, it also describes a basis for an understanding of human as well as technology characteristics that could be incorporated into a prioritization scheme for technology selection and deployment plans.« less

Evaluation of the Inertial Response of Variable-Speed Wind Turbines Using Advanced Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scholbrock, Andrew K; Muljadi, Eduard; Gevorgian, Vahan

In this paper, we focus on the temporary frequency support effect provided by wind turbine generators (WTGs) through the inertial response. With the implemented inertial control methods, the WTG is capable of increasing its active power output by releasing parts of the stored kinetic energy when the frequency excursion occurs. The active power can be boosted temporarily above the maximum power points, but the rotor speed deceleration follows and an active power output deficiency occurs during the restoration of rotor kinetic energy. We evaluate and compare the inertial response induced by two distinct inertial control methods using advanced simulation. Inmore » the first stage, the proposed inertial control methods are analyzed in offline simulation. Using an advanced wind turbine simulation program, FAST with TurbSim, the response of the researched wind turbine is comprehensively evaluated under turbulent wind conditions, and the impact on the turbine mechanical components are assessed. In the second stage, the inertial control is deployed on a real 600kW wind turbine - Controls Advanced Research Turbine, 3-bladed (CART3), which further verifies the inertial control through a hardware-in-the-loop (HIL) simulation. Various inertial control methods can be effectively evaluated based on the proposed two-stage simulation platform, which combines the offline simulation and real-time HIL simulation. The simulation results also provide insights in designing inertial control for WTGs.« less

Advances in simultaneous atmospheric profile and cloud parameter regression based retrieval from high-spectral resolution radiance measurements

NASA Astrophysics Data System (ADS)

Weisz, Elisabeth; Smith, William L.; Smith, Nadia

2013-06-01

The dual-regression (DR) method retrieves information about the Earth surface and vertical atmospheric conditions from measurements made by any high-spectral resolution infrared sounder in space. The retrieved information includes temperature and atmospheric gases (such as water vapor, ozone, and carbon species) as well as surface and cloud top parameters. The algorithm was designed to produce a high-quality product with low latency and has been demonstrated to yield accurate results in real-time environments. The speed of the retrieval is achieved through linear regression, while accuracy is achieved through a series of classification schemes and decision-making steps. These steps are necessary to account for the nonlinearity of hyperspectral retrievals. In this work, we detail the key steps that have been developed in the DR method to advance accuracy in the retrieval of nonlinear parameters, specifically cloud top pressure. The steps and their impact on retrieval results are discussed in-depth and illustrated through relevant case studies. In addition to discussing and demonstrating advances made in addressing nonlinearity in a linear geophysical retrieval method, advances toward multi-instrument geophysical analysis by applying the DR to three different operational sounders in polar orbit are also noted. For any area on the globe, the DR method achieves consistent accuracy and precision, making it potentially very valuable to both the meteorological and environmental user communities.

Nuclease Target Site Selection for Maximizing On-target Activity and Minimizing Off-target Effects in Genome Editing

PubMed Central

Lee, Ciaran M; Cradick, Thomas J; Fine, Eli J; Bao, Gang

2016-01-01

The rapid advancement in targeted genome editing using engineered nucleases such as ZFNs, TALENs, and CRISPR/Cas9 systems has resulted in a suite of powerful methods that allows researchers to target any genomic locus of interest. A complementary set of design tools has been developed to aid researchers with nuclease design, target site selection, and experimental validation. Here, we review the various tools available for target selection in designing engineered nucleases, and for quantifying nuclease activity and specificity, including web-based search tools and experimental methods. We also elucidate challenges in target selection, especially in predicting off-target effects, and discuss future directions in precision genome editing and its applications. PMID:26750397

Big–deep–smart data in imaging for guiding materials design

DOE PAGES

Kalinin, Sergei V.; Sumpter, Bobby G.; Archibald, Richard K.

2015-09-23

Harnessing big data, deep data, and smart data from state-of-the-art imaging might accelerate the design and realization of advanced functional materials. Here we discuss new opportunities in materials design enabled by the availability of big data in imaging and data analytics approaches, including their limitations, in material systems of practical interest. We specifically focus on how these tools might help realize new discoveries in a timely manner. Such methodologies are particularly appropriate to explore in light of continued improvements in atomistic imaging, modelling and data analytics methods.

Laminated turbine vane design and fabrication. [utilizing film cooling as a cooling system

NASA Technical Reports Server (NTRS)

Hess, W. G.

1979-01-01

A turbine vane and associated endwalls designed for advanced gas turbine engine conditions are described. The vane design combines the methods of convection cooling and selective areas of full coverage film cooling. The film cooling technique is utilized on the leading edge, pressure side, and endwall regions. The turbine vane involves the fabrication of airfoils from a stack of laminates with cooling passages photoetched on the surface. Cold flow calibration tests, a thermal analysis, and a stress analysis were performed on the turbine vanes.

The Use of Exergy and Decomposition Techniques in the Development of Generic Analysis, and Optimization Methodologies Applicable to the Synthesis/Design of Aircraft/Aerospace Systems

DTIC Science & Technology

2006-04-21

C. M., and Prendergast, J. P., 2002, "Thermial Analysis of Hypersonic Inlet Flow with Exergy -Based Design Methods," International Journal of Applied...parametric study of the PS and its components is first presented in order to show the type of detailed information on internal system losses which an exergy ...Thermoeconomic Isolation Applied to the Optimal Synthesis/Design of an Advanced Fighter Aircraft System," International Journal of Thermodynamics, ICAT

Big-deep-smart data in imaging for guiding materials design.

PubMed

Kalinin, Sergei V; Sumpter, Bobby G; Archibald, Richard K

2015-10-01

Harnessing big data, deep data, and smart data from state-of-the-art imaging might accelerate the design and realization of advanced functional materials. Here we discuss new opportunities in materials design enabled by the availability of big data in imaging and data analytics approaches, including their limitations, in material systems of practical interest. We specifically focus on how these tools might help realize new discoveries in a timely manner. Such methodologies are particularly appropriate to explore in light of continued improvements in atomistic imaging, modelling and data analytics methods.

Big-deep-smart data in imaging for guiding materials design

NASA Astrophysics Data System (ADS)

Kalinin, Sergei V.; Sumpter, Bobby G.; Archibald, Richard K.

2015-10-01

Harnessing big data, deep data, and smart data from state-of-the-art imaging might accelerate the design and realization of advanced functional materials. Here we discuss new opportunities in materials design enabled by the availability of big data in imaging and data analytics approaches, including their limitations, in material systems of practical interest. We specifically focus on how these tools might help realize new discoveries in a timely manner. Such methodologies are particularly appropriate to explore in light of continued improvements in atomistic imaging, modelling and data analytics methods.

Loss of Coolant Accident (LOCA) / Emergency Core Coolant System (ECCS Evaluation of Risk-Informed Margins Management Strategies for a Representative Pressurized Water Reactor (PWR)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Szilard, Ronaldo Henriques

A Risk Informed Safety Margin Characterization (RISMC) toolkit and methodology are proposed for investigating nuclear power plant core, fuels design and safety analysis, including postulated Loss-of-Coolant Accident (LOCA) analysis. This toolkit, under an integrated evaluation model framework, is name LOCA toolkit for the US (LOTUS). This demonstration includes coupled analysis of core design, fuel design, thermal hydraulics and systems analysis, using advanced risk analysis tools and methods to investigate a wide range of results.

Advanced Extended Plate and Beam Wall System in a Cold-Climate House

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mallay, Dave; Wiehagen, Joseph; Kochkin, Vladimir

This report presents the design and evaluation of an innovative wall system. This highly insulated (high-R) light-frame wall system for use above grade in residential buildings is referred to as Extended Plate & Beam (EP&B). The EP&B design is the first of its kind to be featured in a new construction test house (NCTH) for the DOE Building America program. The EP&B wall design integrates standard building methods and common building products to construct a high-R wall that minimizes transition risks and costs to builders.

Infrastructure Retrofit Design via Composite Mechanics

NASA Technical Reports Server (NTRS)

Chamis, Christos, C.; Gotsis,Pascal K.

1998-01-01

Select applications are described to illustrate the concept for retrofitting reinforced concrete infrastructure with fiber reinforced plastic laminates. The concept is first illustrated by using an axially loaded reinforced concrete column. A reinforced concrete arch and a dome are then used to illustrate the versatility of the concept. Advanced methods such as finite element structural analysis and progressive structural fracture are then used to evaluate the retrofitting laminate adequacy. Results obtains show that retrofits can be designed to double and even triple the as-designed load of the select reinforced concrete infrastructures.

Big–deep–smart data in imaging for guiding materials design

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kalinin, Sergei V.; Sumpter, Bobby G.; Archibald, Richard K.

Harnessing big data, deep data, and smart data from state-of-the-art imaging might accelerate the design and realization of advanced functional materials. Here we discuss new opportunities in materials design enabled by the availability of big data in imaging and data analytics approaches, including their limitations, in material systems of practical interest. We specifically focus on how these tools might help realize new discoveries in a timely manner. Such methodologies are particularly appropriate to explore in light of continued improvements in atomistic imaging, modelling and data analytics methods.

Piloting the membranolytic activities of peptides with a self-organizing map.

PubMed

Lin, Yen-Chu; Hiss, Jan A; Schneider, Petra; Thelesklaf, Peter; Lim, Yi Fan; Pillong, Max; Koehler, Fabian M; Dittrich, Petra S; Halin, Cornelia; Wessler, Silja; Schneider, Gisbert

2014-10-13

Antimicrobial peptides (AMPs) show remarkable selectivity toward lipid membranes and possess promising antibiotic potential. Their modes of action are diverse and not fully understood, and innovative peptide design strategies are needed to generate AMPs with improved properties. We present a de novo peptide design approach that resulted in new AMPs possessing low-nanomolar membranolytic activities. Thermal analysis revealed an entropy-driven mechanism of action. The study demonstrates sustained potential of advanced computational methods for designing peptides with the desired activity. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Design and analytical study of a rotor airfoil

NASA Technical Reports Server (NTRS)

Dadone, L. U.

1978-01-01

An airfoil section for use on helicopter rotor blades was defined and analyzed by means of potential flow/boundary layer interaction and viscous transonic flow methods to meet as closely as possible a set of advanced airfoil design objectives. The design efforts showed that the first priority objectives, including selected low speed pitching moment, maximum lift and drag divergence requirements can be met, though marginally. The maximum lift requirement at M = 0.5 and most of the profile drag objectives cannot be met without some compromise of at least one of the higher order priorities.

New method of contour-based mask-shape compiler

NASA Astrophysics Data System (ADS)

Matsuoka, Ryoichi; Sugiyama, Akiyuki; Onizawa, Akira; Sato, Hidetoshi; Toyoda, Yasutaka

2007-10-01

We have developed a new method of accurately profiling a mask shape by utilizing a Mask CD-SEM. The method is intended to realize high accuracy, stability and reproducibility of the Mask CD-SEM adopting an edge detection algorithm as the key technology used in CD-SEM for high accuracy CD measurement. In comparison with a conventional image processing method for contour profiling, it is possible to create the profiles with much higher accuracy which is comparable with CD-SEM for semiconductor device CD measurement. In this report, we will introduce the algorithm in general, the experimental results and the application in practice. As shrinkage of design rule for semiconductor device has further advanced, an aggressive OPC (Optical Proximity Correction) is indispensable in RET (Resolution Enhancement Technology). From the view point of DFM (Design for Manufacturability), a dramatic increase of data processing cost for advanced MDP (Mask Data Preparation) for instance and surge of mask making cost have become a big concern to the device manufacturers. In a sense, it is a trade-off between the high accuracy RET and the mask production cost, while it gives a significant impact on the semiconductor market centered around the mask business. To cope with the problem, we propose the best method for a DFM solution in which two dimensional data are extracted for an error free practical simulation by precise reproduction of a real mask shape in addition to the mask data simulation. The flow centering around the design data is fully automated and provides an environment where optimization and verification for fully automated model calibration with much less error is available. It also allows complete consolidation of input and output functions with an EDA system by constructing a design data oriented system structure. This method therefore is regarded as a strategic DFM approach in the semiconductor metrology.

Worst case estimation of homology design by convex analysis

NASA Technical Reports Server (NTRS)

Yoshikawa, N.; Elishakoff, Isaac; Nakagiri, S.

1998-01-01

The methodology of homology design is investigated for optimum design of advanced structures. for which the achievement of delicate tasks by the aid of active control system is demanded. The proposed formulation of homology design, based on the finite element sensitivity analysis, necessarily requires the specification of external loadings. The formulation to evaluate the worst case for homology design caused by uncertain fluctuation of loadings is presented by means of the convex model of uncertainty, in which uncertainty variables are assigned to discretized nodal forces and are confined within a conceivable convex hull given as a hyperellipse. The worst case of the distortion from objective homologous deformation is estimated by the Lagrange multiplier method searching the point to maximize the error index on the boundary of the convex hull. The validity of the proposed method is demonstrated in a numerical example using the eleven-bar truss structure.

Parametric study of variation in cargo-airplane performance related to progression from current to spanloader designs

NASA Technical Reports Server (NTRS)

Toll, T. A.

1980-01-01

A parametric analysis was made to investigate the relationship between current cargo airplanes and possible future designs that may differ greatly in both size and configuration. The method makes use of empirical scaling laws developed from statistical studies of data from current and advanced airplanes and, in addition, accounts for payload density, effects of span distributed load, and variations in tail area ratio. The method is believed to be particularly useful for exploratory studies of design and technology options for large airplanes. The analysis predicts somewhat more favorable variations of the ratios of payload to gross weight and block fuel to payload as the airplane size is increased than has been generally understood from interpretations of the cube-square law. In terms of these same ratios, large all wing (spanloader) designs show an advantage over wing-fuselage designs.

Optical design methods, applications, and large optics; Proceedings of the Meeting, Hamburg, Federal Republic of Germany, Sept. 19-21, 1988

NASA Astrophysics Data System (ADS)

Masson, Andre; Schulte In den Baeumen, J.; Zuegge, Hannfried

1989-04-01

Recent advances in the design of large optical components are discussed in reviews and reports. Sections are devoted to calculation and optimization methods, optical-design software, IR optics, diagnosis and tolerancing, image formation, lens design, and large optics. Particular attention is given to the use of the pseudoeikonal in optimization, design with nonsequential ray tracing, aspherics and color-correcting elements in the thermal IR, on-line interferometric mirror-deforming measurement with an Ar-ion laser, and the effect of ametropia on laser-interferometric visual acuity. Also discussed are a holographic head-up display for air and ground applications, high-performance objectives for a digital CCD telecine, the optics of the ESO Very Large Telescope, static wavefront correction by Linnik interferometry, and memory-saving techniques in damped least-squares optimization of complex systems.

Advanced composite elevator for Boeing 727 aircraft, volume 2

NASA Technical Reports Server (NTRS)

Chovil, D. V.; Grant, W. D.; Jamison, E. S.; Syder, H.; Desper, O. E.; Harvey, S. T.; Mccarty, J. E.

1980-01-01

Preliminary design activity consisted of developing and analyzing alternate design concepts and selecting the optimum elevator configuration. This included trade studies in which durability, inspectability, producibility, repairability, and customer acceptance were evaluated. Preliminary development efforts consisted of evaluating and selecting material, identifying ancillary structural development test requirements, and defining full scale ground and flight test requirements necessary to obtain Federal Aviation Administration (FAA) certification. After selection of the optimum elevator configuration, detail design was begun and included basic configuration design improvements resulting from manufacturing verification hardware, the ancillary test program, weight analysis, and structural analysis. Detail and assembly tools were designed and fabricated to support a full-scope production program, rather than a limited run. The producibility development programs were used to verify tooling approaches, fabrication processes, and inspection methods for the production mode. Quality parts were readily fabricated and assembled with a minimum rejection rate, using prior inspection methods.

Simple adaptive control system design for a quadrotor with an internal PFC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mizumoto, Ikuro; Nakamura, Takuto; Kumon, Makoto

2014-12-10

The paper deals with an adaptive control system design problem for a four rotor helicopter or quadrotor. A simple adaptive control design scheme with a parallel feedforward compensator (PFC) in the internal loop of the considered quadrotor will be proposed based on the backstepping strategy. As is well known, the backstepping control strategy is one of the advanced control strategy for nonlinear systems. However, the control algorithm will become complex if the system has higher order relative degrees. We will show that one can skip some design steps of the backstepping method by introducing a PFC in the inner loopmore » of the considered quadrotor, so that the structure of the obtained controller will be simplified and a high gain based adaptive feedback control system will be designed. The effectiveness of the proposed method will be confirmed through numerical simulations.« less

Underwater Advanced Time-Domain Electromagnetic System

DTIC Science & Technology

2017-03-03

SUPPLEMENTARY NOTES 14. ABSTRACT The overall objective of the project is to design , build and demonstrate an underwater advanced time -domain...Description The overall objective of the project is to design , build and demonstrate an underwater advanced time - domain electromagnetic (TEM) system...Electromagnetic System Design (July, 2015), and in the Underwater Advanced Time -Domain Electromagnetic System Evaluation Plan (October, 2016). A

A method of transmissibility design for dual-chamber pneumatic vibration isolator

NASA Astrophysics Data System (ADS)

Lee, Jeung-Hoon; Kim, Kwang-Joon

2009-06-01

Dual-chamber pneumatic vibration isolators have a wide range of applications for vibration isolation of vibration-sensitive equipment. Recent advances in precision machine tools and instruments such as medical devices and those related to nano-technology require better isolation performance, which can be efficiently achieved by precise modeling- and design- of the isolation system. This paper discusses an efficient transmissibility design method of a pneumatic vibration isolator wherein a complex stiffness model of a dual-chamber pneumatic spring developed in our previous study is employed. Three design parameters, the volume ratio between the two pneumatic chambers, the geometry of the capillary tube connecting the two pneumatic chambers, and, finally, the stiffness of the diaphragm employed for prevention of air leakage, were found to be important factors in transmissibility design. Based on a design technique that maximizes damping of the dual-chamber pneumatic spring, trade-offs among the resonance frequency of transmissibility, peak transmissibility, and transmissibility in high frequency range were found, which were not ever stated in previous researches. Furthermore, this paper discusses the negative role of the diaphragm in transmissibility design. The design method proposed in this paper is illustrated through experimental measurements.

Innovative Instrumentation and Analysis of the Temperature Measurement for High Temperature Gasification

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seong W. Lee

The project entitled, ''Innovative Instrumentation and Analysis of the Temperature Measurement for High Temperature Gasification'', was successfully completed by the Principal Investigator, Dr. S. Lee and his research team in the Center for Advanced Energy Systems and Environmental Control Technologies at Morgan State University. The major results and outcomes were presented in semi-annual progress reports and annual project review meetings/presentations. Specifically, the literature survey including the gasifier temperature measurement, the ultrasonic application in cleaning application, and spray coating process and the gasifier simulator (cold model) testing has been successfully conducted during the first year. The results show that four factorsmore » (blower voltage, ultrasonic application, injection time intervals, particle weight) were considered as significant factors that affect the temperature measurement. Then the gasifier simulator (hot model) design and the fabrication as well as the systematic tests on hot model were completed to test the significant factors on temperature measurement in the second year. The advanced Industrial analytic methods such as statistics-based experimental design, analysis of variance (ANOVA) and regression methods were applied in the hot model tests. The results show that operational parameters (i.e. air flow rate, water flow rate, fine dust particle amount, ammonia addition) presented significant impact on the temperature measurement inside the gasifier simulator. The experimental design and ANOVA are very efficient way to design and analyze the experiments. The results show that the air flow rate and fine dust particle amount are statistically significant to the temperature measurement. The regression model provided the functional relation between the temperature and these factors with substantial accuracy. In the last year of the project period, the ultrasonic and subsonic cleaning methods and coating materials were tested/applied on the thermocouple cleaning according to the proposed approach. Different frequency, application time and power of the ultrasonic/subsonic output were tested. The results show that the ultrasonic approach is one of the best methods to clean the thermocouple tips during the routine operation of the gasifier. In addition, the real time data acquisition system was also designed and applied in the experiments. This advanced instrumentation provided the efficient and accurate data acquisition for this project. In summary, the accomplishment of the project provided useful information of the ultrasonic cleaning method applied in thermocouple tip cleaning. The temperature measurement could be much improved both in accuracy and duration provided that the proposed approach is widely used in the gasification facilities.« less

Introduction to Geostatistics

NASA Astrophysics Data System (ADS)

Kitanidis, P. K.

1997-05-01

Introduction to Geostatistics presents practical techniques for engineers and earth scientists who routinely encounter interpolation and estimation problems when analyzing data from field observations. Requiring no background in statistics, and with a unique approach that synthesizes classic and geostatistical methods, this book offers linear estimation methods for practitioners and advanced students. Well illustrated with exercises and worked examples, Introduction to Geostatistics is designed for graduate-level courses in earth sciences and environmental engineering.

Directed evolution: tailoring biocatalysts for industrial applications.

PubMed

Kumar, Ashwani; Singh, Suren

2013-12-01

Current challenges and promises of white biotechnology encourage protein engineers to use a directed evolution approach to generate novel and useful biocatalysts for various sets of applications. Different methods of enzyme engineering have been used in the past in an attempt to produce enzymes with improved functions and properties. Recent advancement in the field of random mutagenesis, screening, selection and computational design increased the versatility and the rapid development of enzymes under strong selection pressure with directed evolution experiments. Techniques of directed evolution improve enzymes fitness without understanding them in great detail and clearly demonstrate its future role in adapting enzymes for use in industry. Despite significant advances to date regarding biocatalyst improvement, there still remains a need to improve mutagenesis strategies and development of easy screening and selection tools without significant human intervention. This review covers fundamental and major development of directed evolution techniques, and highlights the advances in mutagenesis, screening and selection methods with examples of enzymes developed by using these approaches. Several commonly used methods for creating molecular diversity with their advantages and disadvantages including some recently used strategies are also discussed.

Advanced Research and Data Methods in Women's Health: Big Data Analytics, Adaptive Studies, and the Road Ahead.

PubMed

Macedonia, Christian R; Johnson, Clark T; Rajapakse, Indika

2017-02-01

Technical advances in science have had broad implications in reproductive and women's health care. Recent innovations in population-level data collection and storage have made available an unprecedented amount of data for analysis while computational technology has evolved to permit processing of data previously thought too dense to study. "Big data" is a term used to describe data that are a combination of dramatically greater volume, complexity, and scale. The number of variables in typical big data research can readily be in the thousands, challenging the limits of traditional research methodologies. Regardless of what it is called, advanced data methods, predictive analytics, or big data, this unprecedented revolution in scientific exploration has the potential to dramatically assist research in obstetrics and gynecology broadly across subject matter. Before implementation of big data research methodologies, however, potential researchers and reviewers should be aware of strengths, strategies, study design methods, and potential pitfalls. Examination of big data research examples contained in this article provides insight into the potential and the limitations of this data science revolution and practical pathways for its useful implementation.

The Advanced Solid Rocket Motor

NASA Technical Reports Server (NTRS)

Mitchell, Royce E.

1992-01-01

The Advanced Solid Rocket Motor will utilize improved design features and automated manufacturing methods to produce an inherently safer propulsive system for the Space Shuttle and future launch systems. This second-generation motor will also provide an additional 12,000 pounds of payload to orbit, enhancing the utility and efficiency of the Shuttle system. The new plant will feature strip-wound, asbestos-free insulation; propellant continuous mixing and casting; and extensive robotic systems. Following a series of static tests at the Stennis Space Center, MS flights are targeted to begin in early 1997.

Advanced materials for aircraft engine applications.

PubMed

Backman, D G; Williams, J C

1992-02-28

A review of advances for aircraft engine structural materials and processes is presented. Improved materials, such as superalloys, and the processes for making turbine disks and blades have had a major impact on the capability of modern gas turbine engines. New structural materials, notably composites and intermetallic materials, are emerging that will eventually further enhance engine performance, reduce engine weight, and thereby enable new aircraft systems. In the future, successful aerospace manufacturers will combine product design and materials excellence with improved manufacturing methods to increase production efficiency, enhance product quality, and decrease the engine development cycle time.

Advances in traction drive technology

NASA Technical Reports Server (NTRS)

Loewenthal, S. H.; Anderson, N. E.; Rohn, D. A.

1983-01-01

Traction drives are traced from early uses as main transmissions in automobiles at the turn of the century to modern, high-powered traction drives capable of transmitting hundreds of horsepower. Recent advances in technology are described which enable today's traction drive to be a serious candidate for off-highway vehicles and helicopter applications. Improvements in materials, traction fluids, design techniques, power loss and life prediction methods will be highlighted. Performance characteristics of the Nasvytis fixed-ratio drive are given. Promising future drive applications, such as helicopter main transmissions and servo-control positioning mechanisms are also addressed.

Advanced rotorcraft technology: Task force report

NASA Technical Reports Server (NTRS)

1978-01-01

The technological needs and opportunities related to future civil and military rotorcraft were determined and a program plan for NASA research which was responsive to the needs and opportunities was prepared. In general, the program plan places the primary emphasis on design methodology where the development and verification of analytical methods is built upon a sound data base. The four advanced rotorcraft technology elements identified are aerodynamics and structures, flight control and avionic systems, propulsion, and vehicle configurations. Estimates of the total funding levels that would be required to support the proposed program plan are included.

Advanced microprocessor based power protection system using artificial neural network techniques

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Z.; Kalam, A.; Zayegh, A.

This paper describes an intelligent embedded microprocessor based system for fault classification in power system protection system using advanced 32-bit microprocessor technology. The paper demonstrates the development of protective relay to provide overcurrent protection schemes for fault detection. It also describes a method for power fault classification in three-phase system based on the use of neural network technology. The proposed design is implemented and tested on a single line three phase power system in power laboratory. Both the hardware and software development are described in detail.

Advances in bioluminescence imaging: new probes from old recipes.

PubMed

Yao, Zi; Zhang, Brendan S; Prescher, Jennifer A

2018-06-04

Bioluminescent probes are powerful tools for visualizing biology in live tissues and whole animals. Recent years have seen a surge in the number of new luciferases, luciferins, and related tools available for bioluminescence imaging. Many were crafted using classic methods of optical probe design and engineering. Here we highlight recent advances in bioluminescent tool discovery and development, along with applications of the probes in cells, tissues, and organisms. Collectively, these tools are improving in vivo imaging capabilities and bolstering new research directions. Copyright © 2018 Elsevier Ltd. All rights reserved.

Ground truth spectrometry and imagery of eruption clouds to maximize utility of satellite imagery

NASA Technical Reports Server (NTRS)

Rose, William I.

1993-01-01

Field experiments with thermal imaging infrared radiometers were performed and a laboratory system was designed for controlled study of simulated ash clouds. Using AVHRR (Advanced Very High Resolution Radiometer) thermal infrared bands 4 and 5, a radiative transfer method was developed to retrieve particle sizes, optical depth and particle mass involcanic clouds. A model was developed for measuring the same parameters using TIMS (Thermal Infrared Multispectral Scanner), MODIS (Moderate Resolution Imaging Spectrometer), and ASTER (Advanced Spaceborne Thermal Emission and Reflection Radiometer). Related publications are attached.

Designing Citizen Science Projects in the Era of Mega-Information and Connected Activism

NASA Astrophysics Data System (ADS)

Pompea, S. M.

2010-12-01

The design of citizen science projects must take many factors into account in order to be successful. Currently, there are a wide variety of citizen science projects with different aims, audiences, reporting methods, and degrees of scientific rigor and usefulness. Projects function on local, national, and worldwide scales and range in time from limited campaigns to around the clock projects. For current and future projects, advanced cell phones and mobile computing allow an unprecedented degree of connectivity and data transfer. These advances will greatly influence the design of citizen science projects. An unprecedented amount of data is available for data mining by interested citizen scientists; how can projects take advantage of this? Finally, a variety of citizen scientist projects have social activism and change as part of their mission and goals. How can this be harnessed in a constructive and efficient way? The design of projects must also select the proper role for experts and novices, provide quality control, and must motivate users to encourage long-term involvement. Effective educational and instructional materials design can be used to design responsive and effective projects in a more highly connected age with access to very large amounts of information.

Advanced Extra-Vehicular Activity Pressure Garment Requirements Development

NASA Technical Reports Server (NTRS)

Ross, Amy; Aitchison, Lindsay; Rhodes, Richard

2015-01-01

The NASA Johnson Space Center advanced pressure garment technology development team is addressing requirements development for exploration missions. Lessons learned from the Z-2 high fidelity prototype development have reiterated that clear low-level requirements and verification methods reduce risk to the government, improve efficiency in pressure garment design efforts, and enable the government to be a smart buyer. The expectation is to provide requirements at the specification level that are validated so that their impact on pressure garment design is understood. Additionally, the team will provide defined verification protocols for the requirements. However, in reviewing exploration space suit high level requirements there are several gaps in the team's ability to define and verify related lower level requirements. This paper addresses the efforts in requirement areas such as mobility/fit/comfort and environmental protection (dust, radiation, plasma, secondary impacts) to determine the method by which the requirements can be defined and use of those methods for verification. Gaps exist at various stages. In some cases component level work is underway, but no system level effort has begun; in other cases no effort has been initiated to close the gap. Status of on-going efforts and potential approaches to open gaps are discussed.

NASA's Aeroacoustic Tools and Methods for Analysis of Aircraft Noise

NASA Technical Reports Server (NTRS)

Rizzi, Stephen A.; Lopes, Leonard V.; Burley, Casey L.

2015-01-01

Aircraft community noise is a significant concern due to continued growth in air traffic, increasingly stringent environmental goals, and operational limitations imposed by airport authorities. The ability to quantify aircraft noise at the source and ultimately at observers is required to develop low noise aircraft designs and flight procedures. Predicting noise at the source, accounting for scattering and propagation through the atmosphere to the observer, and assessing the perception and impact on a community requires physics-based aeroacoustics tools. Along with the analyses for aero-performance, weights and fuel burn, these tools can provide the acoustic component for aircraft MDAO (Multidisciplinary Design Analysis and Optimization). Over the last decade significant progress has been made in advancing the aeroacoustic tools such that acoustic analyses can now be performed during the design process. One major and enabling advance has been the development of the system noise framework known as Aircraft NOise Prediction Program2 (ANOPP2). ANOPP2 is NASA's aeroacoustic toolset and is designed to facilitate the combination of acoustic approaches of varying fidelity for the analysis of noise from conventional and unconventional aircraft. The toolset includes a framework that integrates noise prediction and propagation methods into a unified system for use within general aircraft analysis software. This includes acoustic analyses, signal processing and interfaces that allow for the assessment of perception of noise on a community. ANOPP2's capability to incorporate medium fidelity shielding predictions and wind tunnel experiments into a design environment is presented. An assessment of noise from a conventional and Hybrid Wing Body (HWB) aircraft using medium fidelity scattering methods combined with noise measurements from a model-scale HWB recently placed in NASA's 14x22 wind tunnel are presented. The results are in the form of community noise metrics and auralizations.

Protein Quantification by Elemental Mass Spectrometry: An Experiment for Graduate Students

ERIC Educational Resources Information Center

Schwarz, Gunnar; Ickert, Stefanie; Wegner, Nina; Nehring, Andreas; Beck, Sebastian; Tiemann, Ruediger; Linscheid, Michael W.

2014-01-01

A multiday laboratory experiment was designed to integrate inductively coupled plasma-mass spectrometry (ICP-MS) in the context of protein quantification into an advanced practical course in analytical and environmental chemistry. Graduate students were familiar with the analytical methods employed, whereas the combination of bioanalytical assays…

Determination of Acidity Constants by Gradient Flow-Injection Titration

ERIC Educational Resources Information Center

Conceicao, Antonio C. L.; Minas da Piedade, Manuel E.

2006-01-01

A three-hour laboratory experiment, designed for an advanced undergraduate course in instrumental analysis that illustrates the application of the gradient chamber flow-injection titration (GCFIT) method with spectrophotometric detection to determine acidity constants is presented. The procedure involves the use of an acid-base indicator to obtain…

77 FR 59998 - Self-Regulatory Organizations; The Options Clearing Corporation; Advance Notice Relating to the...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-01

... System for Theoretical Analysis and Numerical Simulations (``STANS''). STANS calculates margin with...'' simulations designed to measure the additional asset value required in any portfolio to eliminate an... Commission process and review your comments more efficiently, please use only one method. The Commission will...

Two Crystallographic Laboratory and Computational Exercises for Undergraduates.

ERIC Educational Resources Information Center

Lessinger, Leslie

1988-01-01

Describes two introductory exercises designed to teach the fundamental ideas and methods of crystallography, and to convey some important features of inorganic and organic crystal structures to students in an advanced laboratory course. Exercises include "The Crystal Structure of NiO" and "The Crystal Structure of Beta-Fumaric Acid." (CW)

Joint ETV/NOWATECH test plan for the Sorbisense GSW40 passive sampler

EPA Science Inventory

The joint test plan is the implementation of a test design developed for verification of the performance of an environmental technology following the NOWATECH ETV method. The verification is a joint verification with the US EPA ETV scheme and the Advanced Monitoring Systems Cent...

Washington Manual: A New Tool for Local School Accounting

ERIC Educational Resources Information Center

Federal Aid Planner, 1972

1972-01-01

An advance glimpse of the revised financial accounting methods for school districts recommended in a new manual from the U. S. Office of Education. The manual is designed to help school districts modernize their financial accounting procedures and their entire range of fiscal management practices. (Author/DN)

e-Learning Success Model: An Information Systems Perspective

ERIC Educational Resources Information Center

Lee-Post, Anita

2009-01-01

This paper reports the observations made and experience gained from developing and delivering an online quantitative methods course for Business undergraduates. Inspired by issues and challenges experienced in developing the online course, a model is advanced to address the question of how to guide the design, development, and delivery of…

Regulation of Iron Acquisition Responses in Plant Roots by a Transcription Factor

ERIC Educational Resources Information Center

Bauer, Petra

2016-01-01

The presented research hypothesis-driven laboratory exercise teaches advanced undergraduate students state of the art methods and thinking in an integrated molecular physiology context. Students understand the theoretical background of iron acquisition in the model plant "Arabidopsis thaliana." They design a flowchart summarizing the key…

Design, ancillary testing, analysis and fabrication data for the advanced composite stabilizer for Boeing 737 aircraft. Volume 1: Technical summary

NASA Technical Reports Server (NTRS)

Aniversario, R. B.; Harvey, S. T.; Mccarty, J. E.; Parsons, J. T.; Peterson, D. C.; Pritchett, L. D.; Wilson, D. R.; Wogulis, E. R.

1983-01-01

The horizontal stabilizer of the 737 transport was redesigned. Five shipsets were fabricated using composite materials. Weight reduction greater than the 20% goal was achieved. Parts and assemblies were readily produced on production-type tooling. Quality assurance methods were demonstrated. Repair methods were developed and demonstrated. Strength and stiffness analytical methods were substantiated by comparison with test results. Cost data was accumulated in a semiproduction environment. FAA certification was obtained.

EpiModel: An R Package for Mathematical Modeling of Infectious Disease over Networks.

PubMed

Jenness, Samuel M; Goodreau, Steven M; Morris, Martina

2018-04-01

Package EpiModel provides tools for building, simulating, and analyzing mathematical models for the population dynamics of infectious disease transmission in R. Several classes of models are included, but the unique contribution of this software package is a general stochastic framework for modeling the spread of epidemics on networks. EpiModel integrates recent advances in statistical methods for network analysis (temporal exponential random graph models) that allow the epidemic modeling to be grounded in empirical data on contacts that can spread infection. This article provides an overview of both the modeling tools built into EpiModel , designed to facilitate learning for students new to modeling, and the application programming interface for extending package EpiModel , designed to facilitate the exploration of novel research questions for advanced modelers.

EpiModel: An R Package for Mathematical Modeling of Infectious Disease over Networks

PubMed Central

Jenness, Samuel M.; Goodreau, Steven M.; Morris, Martina

2018-01-01

Package EpiModel provides tools for building, simulating, and analyzing mathematical models for the population dynamics of infectious disease transmission in R. Several classes of models are included, but the unique contribution of this software package is a general stochastic framework for modeling the spread of epidemics on networks. EpiModel integrates recent advances in statistical methods for network analysis (temporal exponential random graph models) that allow the epidemic modeling to be grounded in empirical data on contacts that can spread infection. This article provides an overview of both the modeling tools built into EpiModel, designed to facilitate learning for students new to modeling, and the application programming interface for extending package EpiModel, designed to facilitate the exploration of novel research questions for advanced modelers. PMID:29731699

High-Pressure Design of Advanced BN-Based Materials.

PubMed

Kurakevych, Oleksandr O; Solozhenko, Vladimir L

2016-10-20

The aim of the present review is to highlight the state of the art in high-pressure design of new advanced materials based on boron nitride. Recent experimental achievements on the governing phase transformation, nanostructuring and chemical synthesis in the systems containing boron nitride at high pressures and high temperatures are presented. All these developments allowed discovering new materials, e.g., ultrahard nanocrystalline cubic boron nitride (nano-cBN) with hardness comparable to diamond, and superhard boron subnitride B 13 N₂. Thermodynamic and kinetic aspects of high-pressure synthesis are described based on the data obtained by in situ and ex situ methods. Mechanical and thermal properties (hardness, thermoelastic equations of state, etc.) are discussed. New synthetic perspectives, combining both soft chemistry and extreme pressure-temperature conditions are considered.

Thermal Analysis and Design of an Advanced Space Suit

NASA Technical Reports Server (NTRS)

Lin, Chin H.; Campbell, Anthony B.; French, Jonathan D.; French, D.; Nair, Satish S.; Miles, John B.

2000-01-01

The thermal dynamics and design of an Advanced Space Suit are considered. A transient model of the Advanced Space Suit has been developed and implemented using MATLAB/Simulink to help with sizing, with design evaluation, and with the development of an automatic thermal comfort control strategy. The model is described and the thermal characteristics of the Advanced Space suit are investigated including various parametric design studies. The steady state performance envelope for the Advanced Space Suit is defined in terms of the thermal environment and human metabolic rate and the transient response of the human-suit-MPLSS system is analyzed.

Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm

NASA Technical Reports Server (NTRS)

Robinson, John W.; McCleskey, Carey M.; Rhodes, Russel E.; Lepsch, Roger A.; Henderson, Edward M.; Joyner, Claude R., III; Levack, Daniel J. H.

2013-01-01

This paper describes Advanced Space Transportation Concepts and Propulsion Technologies for a New Delivery Paradigm. It builds on the work of the previous paper "Approach to an Affordable and Productive Space Transportation System". The scope includes both flight and ground system elements, and focuses on their compatibility and capability to achieve a technical solution that is operationally productive and also affordable. A clear and revolutionary approach, including advanced propulsion systems (advanced LOX rich booster engine concept having independent LOX and fuel cooling systems, thrust augmentation with LOX rich boost and fuel rich operation at altitude), improved vehicle concepts (autogeneous pressurization, turbo alternator for electric power during ascent, hot gases to purge system and keep moisture out), and ground delivery systems, was examined. Previous papers by the authors and other members of the Space Propulsion Synergy Team (SPST) focused on space flight system engineering methods, along with operationally efficient propulsion system concepts and technologies. This paper continues the previous work by exploring the propulsion technology aspects in more depth and how they may enable the vehicle designs from the previous paper. Subsequent papers will explore the vehicle design, the ground support system, and the operations aspects of the new delivery paradigm in greater detail.

Atacama Cosmology Telescope: Polarization calibration analysis for CMB measurements with ACTPol and Advanced ACTPol

NASA Astrophysics Data System (ADS)

Koopman, Brian; ACTPol Collaboration

2015-04-01

The Atacama Cosmology Telescope Polarimeter (ACTPol) is a polarization sensitive upgrade for the Atacama Cosmology Telescope, located at an elevation of 5190 m on Cerro Toco in Chile. Achieving first light in 2013, ACTPol is entering its third observation season. Advanced ACTPol is a next generation upgrade for ACTPol, with additional frequencies, polarization modulation, and new detector arrays, that will begin in 2016. I will first present an overview of the two projects and then focus on describing the methods used for polarization angle calibration of the ACTPol detectors. These methods utilize polarization ray tracing in the optical design software CODEV together with detector positions determined from planet observations and represent a critical input for mapping the polarization of the CMB.

Periodic control of the individual-blade-control helicopter rotor

NASA Technical Reports Server (NTRS)

Mckillip, R. M., Jr.

1985-01-01

This paper describes the results of an investigation into methods of controller design for linear periodic systems utilizing an extension of modern control methods. Trends present in the selection of various cost functions are outlined, and closed-loop controller results are demonstrated for two cases: first, on an analog computer simulation of the rigid out of plane flapping dynamics of a single rotor blade, and second, on a 4 ft diameter single-bladed model helicopter rotor in the MIT 5 x 7 subsonic wind tunnel, both for various high levels of advance ratio. It is shown that modal control using the IBC concept is possible over a large range of advance ratios with only a modest amount of computational power required.

Effect of processing on Polymer/Composite structure and properties

NASA Technical Reports Server (NTRS)

1982-01-01

Advances in the vitality and economic health of the field of polymer forecasting are discussed. A consistent and rational point of view which considers processing as a participant in the underlying triad of relationships which comprise materials science and engineering is outlined. This triad includes processing as it influences material structure, and ultimately properties. Methods in processing structure properties, polymer science and engineering, polymer chemistry and synthesis, structure and modification and optimization through processing, and methods of melt flow modeling in processing structure property relations of polymer were developed. Mechanical properties of composites are considered, and biomedical materials research to include polymer processing effects are studied. An analysis of the design technology of advances graphite/epoxy composites is also reported.

Advanced stability indicating chemometric methods for quantitation of amlodipine and atorvastatin in their quinary mixture with acidic degradation products

NASA Astrophysics Data System (ADS)

Darwish, Hany W.; Hassan, Said A.; Salem, Maissa Y.; El-Zeany, Badr A.

2016-02-01

Two advanced, accurate and precise chemometric methods are developed for the simultaneous determination of amlodipine besylate (AML) and atorvastatin calcium (ATV) in the presence of their acidic degradation products in tablet dosage forms. The first method was Partial Least Squares (PLS-1) and the second was Artificial Neural Networks (ANN). PLS was compared to ANN models with and without variable selection procedure (genetic algorithm (GA)). For proper analysis, a 5-factor 5-level experimental design was established resulting in 25 mixtures containing different ratios of the interfering species. Fifteen mixtures were used as calibration set and the other ten mixtures were used as validation set to validate the prediction ability of the suggested models. The proposed methods were successfully applied to the analysis of pharmaceutical tablets containing AML and ATV. The methods indicated the ability of the mentioned models to solve the highly overlapped spectra of the quinary mixture, yet using inexpensive and easy to handle instruments like the UV-VIS spectrophotometer.

Computational Methods Development at Ames

NASA Technical Reports Server (NTRS)

Kwak, Dochan; Smith, Charles A. (Technical Monitor)

1998-01-01

This viewgraph presentation outlines the development at Ames Research Center of advanced computational methods to provide appropriate fidelity computational analysis/design capabilities. Current thrusts of the Ames research include: 1) methods to enhance/accelerate viscous flow simulation procedures, and the development of hybrid/polyhedral-grid procedures for viscous flow; 2) the development of real time transonic flow simulation procedures for a production wind tunnel, and intelligent data management technology; and 3) the validation of methods and the flow physics study gives historical precedents to above research, and speculates on its future course.

Probability techniques for reliability analysis of composite materials

NASA Technical Reports Server (NTRS)

Wetherhold, Robert C.; Ucci, Anthony M.

1994-01-01

Traditional design approaches for composite materials have employed deterministic criteria for failure analysis. New approaches are required to predict the reliability of composite structures since strengths and stresses may be random variables. This report will examine and compare methods used to evaluate the reliability of composite laminae. The two types of methods that will be evaluated are fast probability integration (FPI) methods and Monte Carlo methods. In these methods, reliability is formulated as the probability that an explicit function of random variables is less than a given constant. Using failure criteria developed for composite materials, a function of design variables can be generated which defines a 'failure surface' in probability space. A number of methods are available to evaluate the integration over the probability space bounded by this surface; this integration delivers the required reliability. The methods which will be evaluated are: the first order, second moment FPI methods; second order, second moment FPI methods; the simple Monte Carlo; and an advanced Monte Carlo technique which utilizes importance sampling. The methods are compared for accuracy, efficiency, and for the conservativism of the reliability estimation. The methodology involved in determining the sensitivity of the reliability estimate to the design variables (strength distributions) and importance factors is also presented.

System Sensitivity Analysis Applied to the Conceptual Design of a Dual-Fuel Rocket SSTO

NASA Technical Reports Server (NTRS)

Olds, John R.

1994-01-01

This paper reports the results of initial efforts to apply the System Sensitivity Analysis (SSA) optimization method to the conceptual design of a single-stage-to-orbit (SSTO) launch vehicle. SSA is an efficient, calculus-based MDO technique for generating sensitivity derivatives in a highly multidisciplinary design environment. The method has been successfully applied to conceptual aircraft design and has been proven to have advantages over traditional direct optimization methods. The method is applied to the optimization of an advanced, piloted SSTO design similar to vehicles currently being analyzed by NASA as possible replacements for the Space Shuttle. Powered by a derivative of the Russian RD-701 rocket engine, the vehicle employs a combination of hydrocarbon, hydrogen, and oxygen propellants. Three primary disciplines are included in the design - propulsion, performance, and weights & sizing. A complete, converged vehicle analysis depends on the use of three standalone conceptual analysis computer codes. Efforts to minimize vehicle dry (empty) weight are reported in this paper. The problem consists of six system-level design variables and one system-level constraint. Using SSA in a 'manual' fashion to generate gradient information, six system-level iterations were performed from each of two different starting points. The results showed a good pattern of convergence for both starting points. A discussion of the advantages and disadvantages of the method, possible areas of improvement, and future work is included.

Study on the Integrated Geophysic Methods and Application of Advanced Geological Detection for Complicated Tunnel

NASA Astrophysics Data System (ADS)

Zhou, L.; Xiao, G.

2014-12-01

The engineering geological and hydrological conditions of current tunnels are more and more complicated, as the tunnels are elongated with deeper depth. In constructing these complicated tunnels, geological hazards prone to occur as induced by unfavorable geological bodies, such as fault zones, karst or hydrous structures, etc. The working emphasis and difficulty of the advanced geological exploration for complicated tunnels are mainly focused on the structure and water content of these unfavorable geological bodies. The technical aspects of my paper systematically studied the advanced geological exploration theory and application aspects for complicated tunnels, with discussion on the key technical points and useful conclusions. For the all-aroundness and accuracy of advanced geological exploration results, the objective of my paper is targeted on the comprehensive examination on the structure and hydrous characteristic of the unfavorable geological bodies in complicated tunnels. By the multi-component seismic modeling on a more real model containing the air medium, the wave field response characteristics of unfavorable geological bodies can be analyzed, thus providing theoretical foundation for the observation system layout, signal processing and interpretation of seismic methods. Based on the tomographic imaging theory of seismic and electromagnetic method, 2D integrated seismic and electromagnetic tomographic imaging and visualization software was designed and applied in the advanced drilling hole in the tunnel face, after validation of the forward and inverse modeling results on theoretical models. The transmission wave imaging technology introduced in my paper can be served as a new criterion for detection of unfavorable geological bodies. After careful study on the basic theory, data processing and interpretation, practical applications of TSP and ground penetrating radar (GPR) method, as well as serious examination on their application examples, my paper formulated a suite of comprehensive application system of seismic and electromagnetic methods for the advanced geological exploration of complicated tunnels. This research is funded by National Natural Science Foundation of China (Grant No. 41202223) .

Survey of Verification and Validation Techniques for Small Satellite Software Development

NASA Technical Reports Server (NTRS)

Jacklin, Stephen A.

2015-01-01

The purpose of this paper is to provide an overview of the current trends and practices in small-satellite software verification and validation. This document is not intended to promote a specific software assurance method. Rather, it seeks to present an unbiased survey of software assurance methods used to verify and validate small satellite software and to make mention of the benefits and value of each approach. These methods include simulation and testing, verification and validation with model-based design, formal methods, and fault-tolerant software design with run-time monitoring. Although the literature reveals that simulation and testing has by far the longest legacy, model-based design methods are proving to be useful for software verification and validation. Some work in formal methods, though not widely used for any satellites, may offer new ways to improve small satellite software verification and validation. These methods need to be further advanced to deal with the state explosion problem and to make them more usable by small-satellite software engineers to be regularly applied to software verification. Last, it is explained how run-time monitoring, combined with fault-tolerant software design methods, provides an important means to detect and correct software errors that escape the verification process or those errors that are produced after launch through the effects of ionizing radiation.

Preliminary Tritium Management Design Activities at ORNL

DOE Office of Scientific and Technical Information (OSTI.GOV)

Harrison, Thomas J.; Felde, David K.; Logsdon, Randall J.

2016-09-01

Interest in salt-cooled and salt-fueled reactors has increased over the last decade (Forsberg et al. 2016). Several private companies and universities in the United States, as well as governments in other countries, are developing salt reactor designs and/or technology. Two primary issues for the development and deployment of many salt reactor concepts are (1) the prevention of tritium generation and (2) the management of tritium to prevent release to the environment. In 2016, the US Department of Energy (DOE) initiated a research project under the Advanced Reactor Technology Program to (1) experimentally assess the feasibility of proposed methods for tritiummore » mitigation and (2) to perform an engineering demonstration of the most promising methods. This document describes results from the first year’s efforts to define, design, and build an experimental apparatus to test potential methods for tritium management. These efforts are focused on producing a final design document as the basis for the apparatus and its scheduled completion consistent with available budget and approvals for facility use.« less

Exact tests using two correlated binomial variables in contemporary cancer clinical trials.

PubMed

Yu, Jihnhee; Kepner, James L; Iyer, Renuka

2009-12-01

New therapy strategies for the treatment of cancer are rapidly emerging because of recent technology advances in genetics and molecular biology. Although newer targeted therapies can improve survival without measurable changes in tumor size, clinical trial conduct has remained nearly unchanged. When potentially efficacious therapies are tested, current clinical trial design and analysis methods may not be suitable for detecting therapeutic effects. We propose an exact method with respect to testing cytostatic cancer treatment using correlated bivariate binomial random variables to simultaneously assess two primary outcomes. The method is easy to implement. It does not increase the sample size over that of the univariate exact test and in most cases reduces the sample size required. Sample size calculations are provided for selected designs.

Evaluation Methodologies for Information Management Systems; Building Digital Tobacco Industry Document Libraries at the University of California, San Francisco Library/Center for Knowledge Management; Experiments with the IFLA Functional Requirements for Bibliographic Records (FRBR); Coming to Term: Designing the Texas Email Repository Model.

ERIC Educational Resources Information Center

Morse, Emile L.; Schmidt, Heidi; Butter, Karen; Rider, Cynthia; Hickey, Thomas B.; O'Neill, Edward T.; Toves, Jenny; Green, Marlan; Soy, Sue; Gunn, Stan; Galloway, Patricia

2002-01-01

Includes four articles that discuss evaluation methods for information management systems under the Defense Advanced Research Projects Agency; building digital libraries at the University of California San Francisco's Tobacco Control Archives; IFLA's Functional Requirements for Bibliographic Records; and designing the Texas email repository model…

Peculiarities of Natural Technology Application in Architecture

NASA Astrophysics Data System (ADS)

Umorina, Z.

2017-11-01

Technical advancement of the modern world has made it possible to create unique artificial objects based on the natural technology principle. New engineering and design types, such as computational design, additive manufacturing, materials engineering, synthetic biology, etc. allow us to enter a new level of interaction between a human being and nature. This influences the formation of a new world view in the sphere of architecture and leads to the development of new methods and styles [1,2].

The 1981 NASA/ASEE Summer Faculty Fellowship Program: Research reports

NASA Technical Reports Server (NTRS)

Karr, G. R.; Dozier, J. B.; Kent, M. I.; Barfield, B. F.

1982-01-01

Research reports related to spacecraft industry technological advances, requirements, and applications were considered. Some of the topic areas addressed were: (1) Fabrication, evaluation, and use of high performance composites and ceramics, (2) antenna designs, (3) electronics and microcomputer applications and mathematical modeling and programming techniques, (4) design, fabrication, and failure detection methods for structural materials, components, and total systems, and (5) chemical studies of bindary organic mixtures and polymer synthesis. Space environment parameters were also discussed.

Optimization of Microelectronic Devices for Sensor Applications

NASA Technical Reports Server (NTRS)

Cwik, Tom; Klimeck, Gerhard

2000-01-01

The NASA/JPL goal to reduce payload in future space missions while increasing mission capability demands miniaturization of active and passive sensors, analytical instruments and communication systems among others. Currently, typical system requirements include the detection of particular spectral lines, associated data processing, and communication of the acquired data to other systems. Advances in lithography and deposition methods result in more advanced devices for space application, while the sub-micron resolution currently available opens a vast design space. Though an experimental exploration of this widening design space-searching for optimized performance by repeated fabrication efforts-is unfeasible, it does motivate the development of reliable software design tools. These tools necessitate models based on fundamental physics and mathematics of the device to accurately model effects such as diffraction and scattering in opto-electronic devices, or bandstructure and scattering in heterostructure devices. The software tools must have convenient turn-around times and interfaces that allow effective usage. The first issue is addressed by the application of high-performance computers and the second by the development of graphical user interfaces driven by properly developed data structures. These tools can then be integrated into an optimization environment, and with the available memory capacity and computational speed of high performance parallel platforms, simulation of optimized components can proceed. In this paper, specific applications of the electromagnetic modeling of infrared filtering, as well as heterostructure device design will be presented using genetic algorithm global optimization methods.

Computational and design methods for advanced imaging

NASA Astrophysics Data System (ADS)

Birch, Gabriel C.

This dissertation merges the optical design and computational aspects of imaging systems to create novel devices that solve engineering problems in optical science and attempts to expand the solution space available to the optical designer. This dissertation is divided into two parts: the first discusses a new active illumination depth sensing modality, while the second part discusses a passive illumination system called plenoptic, or lightfield, imaging. The new depth sensing modality introduced in part one is called depth through controlled aberration. This technique illuminates a target with a known, aberrated projected pattern and takes an image using a traditional, unmodified imaging system. Knowing how the added aberration in the projected pattern changes as a function of depth, we are able to quantitatively determine depth of a series of points from the camera. A major advantage this method permits is the ability for illumination and imaging axes to be coincident. Plenoptic cameras capture both spatial and angular data simultaneously. This dissertation present a new set of parameters that permit the design and comparison of plenoptic devices outside the traditionally published plenoptic 1.0 and plenoptic 2.0 configurations. Additionally, a series of engineering advancements are presented, including full system raytraces of raw plenoptic images, Zernike compression techniques of raw image files, and non-uniform lenslet arrays to compensate for plenoptic system aberrations. Finally, a new snapshot imaging spectrometer is proposed based off the plenoptic configuration.

Experimental Robot Position Sensor Fault Tolerance Using Accelerometers and Joint Torque Sensors

NASA Technical Reports Server (NTRS)

Aldridge, Hal A.; Juang, Jer-Nan

1997-01-01

Robot systems in critical applications, such as those in space and nuclear environments, must be able to operate during component failure to complete important tasks. One failure mode that has received little attention is the failure of joint position sensors. Current fault tolerant designs require the addition of directly redundant position sensors which can affect joint design. The proposed method uses joint torque sensors found in most existing advanced robot designs along with easily locatable, lightweight accelerometers to provide a joint position sensor fault recovery mode. This mode uses the torque sensors along with a virtual passive control law for stability and accelerometers for joint position information. Two methods for conversion from Cartesian acceleration to joint position based on robot kinematics, not integration, are presented. The fault tolerant control method was tested on several joints of a laboratory robot. The controllers performed well with noisy, biased data and a model with uncertain parameters.

H(2)- and H(infinity)-design tools for linear time-invariant systems

NASA Technical Reports Server (NTRS)

Ly, Uy-Loi

1989-01-01

Recent advances in optimal control have brought design techniques based on optimization of H(2) and H(infinity) norm criteria, closer to be attractive alternatives to single-loop design methods for linear time-variant systems. Significant steps forward in this technology are the deeper understanding of performance and robustness issues of these design procedures and means to perform design trade-offs. However acceptance of the technology is hindered by the lack of convenient design tools to exercise these powerful multivariable techniques, while still allowing single-loop design formulation. Presented is a unique computer tool for designing arbitrary low-order linear time-invarient controllers than encompasses both performance and robustness issues via the familiar H(2) and H(infinity) norm optimization. Application to disturbance rejection design for a commercial transport is demonstrated.

A knowledge-based system design/information tool for aircraft flight control systems

NASA Technical Reports Server (NTRS)

Mackall, Dale A.; Allen, James G.

1991-01-01

Research aircraft have become increasingly dependent on advanced electronic control systems to accomplish program goals. These aircraft are integrating multiple disciplines to improve performance and satisfy research objective. This integration is being accomplished through electronic control systems. Systems design methods and information management have become essential to program success. The primary objective of the system design/information tool for aircraft flight control is to help transfer flight control system design knowledge to the flight test community. By providing all of the design information and covering multiple disciplines in a structured, graphical manner, flight control systems can more easily be understood by the test engineers. This will provide the engineers with the information needed to thoroughly ground test the system and thereby reduce the likelihood of serious design errors surfacing in flight. The secondary object is to apply structured design techniques to all of the design domains. By using the techniques in the top level system design down through the detailed hardware and software designs, it is hoped that fewer design anomalies will result. The flight test experiences are reviewed of three highly complex, integrated aircraft programs: the X-29 forward swept wing; the advanced fighter technology integration (AFTI) F-16; and the highly maneuverable aircraft technology (HiMAT) program. Significant operating technologies, and the design errors which cause them, is examined to help identify what functions a system design/informatin tool should provide to assist designers in avoiding errors.

Advanced psychiatric nurse practitioners' ideas and needs for supervision in private practice in South Africa.

PubMed

Temane, Annie M; Poggenpoel, Marie; Myburgh, Chris P H

2014-04-07

Supervision forms an integral part of psychiatric nursing. The value of clinicalsupervision has been demonstrated widely in research. Despite efforts made toward advancedpsychiatric nursing, supervision seems to be non-existent in this field. The aim of this study was to explore and describe advanced psychiatric nursepractitioners' ideas and needs with regard to supervision in private practice in order tocontribute to the new efforts made in advanced psychiatric nursing in South Africa. A qualitative, descriptive, exploratory, and contextual design using a phenomenological approach as research method was utilised in this study. A purposive sampling was used. Eight advanced psychiatric nurse practitioners in private practice described their ideas and needs for supervision during phenomenological interviews. Tesch's method of open coding was utilised to analyse data. After data analysis the findings were recontextualised within literature. The data analysis generated the following themes - that the supervisor should have or possess: (a) professional competencies, (b) personal competencies and (c) specificfacilitative communication skills. The findings indicated that there was a need for supervision of advanced psychiatric nurse practitioners in private practice in South Africa. This study indicates that there is need for supervision and competent supervisors in private practice. Supervision can be beneficial with regard to developing a culture of support for advanced psychiatric practitioners in private practice and also psychiatric nurse practitioners.

A Control Law Design Method Facilitating Control Power, Robustness, Agility, and Flying Qualities Tradeoffs: CRAFT

NASA Technical Reports Server (NTRS)

Murphy, Patrick C.; Davidson, John B.

1998-01-01

A multi-input, multi-output control law design methodology, named "CRAFT", is presented. CRAFT stands for the design objectives addressed, namely, Control power, Robustness, Agility, and Flying Qualities Tradeoffs. The methodology makes use of control law design metrics from each of the four design objective areas. It combines eigenspace assignment, which allows for direct specification of eigenvalues and eigenvectors, with a graphical approach for representing the metrics that captures numerous design goals in one composite illustration. Sensitivity of the metrics to eigenspace choice is clearly displayed, enabling the designer to assess the cost of design tradeoffs. This approach enhances the designer's ability to make informed design tradeoffs and to reach effective final designs. An example of the CRAFT methodology applied to an advanced experimental fighter and discussion of associated design issues are provided.

Transcranial magnetic stimulation assisted by neuronavigation of magnetic resonance images

NASA Astrophysics Data System (ADS)

Viesca, N. Angeline; Alcauter, S. Sarael; Barrios, A. Fernando; González, O. Jorge J.; Márquez, F. Jorge A.

2012-10-01

Technological advance has improved the way scientists and doctors can learn about the brain and treat different disorders. A non-invasive method used for this is Transcranial Magnetic Stimulation (TMS) based on neuron excitation by electromagnetic induction. Combining this method with functional Magnetic Resonance Images (fMRI), it is intended to improve the localization technique of cortical brain structures by designing an extracranial localization system, based on Alcauter et al. work.

A Tutorial on Adaptive Design Optimization

PubMed Central

Myung, Jay I.; Cavagnaro, Daniel R.; Pitt, Mark A.

2013-01-01

Experimentation is ubiquitous in the field of psychology and fundamental to the advancement of its science, and one of the biggest challenges for researchers is designing experiments that can conclusively discriminate the theoretical hypotheses or models under investigation. The recognition of this challenge has led to the development of sophisticated statistical methods that aid in the design of experiments and that are within the reach of everyday experimental scientists. This tutorial paper introduces the reader to an implementable experimentation methodology, dubbed Adaptive Design Optimization, that can help scientists to conduct “smart” experiments that are maximally informative and highly efficient, which in turn should accelerate scientific discovery in psychology and beyond. PMID:23997275

Research on digital system design of nuclear power valve

NASA Astrophysics Data System (ADS)

Zhang, Xiaolong; Li, Yuan; Wang, Tao; Dai, Ye

2018-04-01

With the progress of China's nuclear power industry, nuclear power plant valve products is in a period of rapid development, high performance, low cost, short cycle of design requirements for nuclear power valve is proposed, so there is an urgent need for advanced digital design method and integrated design platform to provide technical support. Especially in the background of the nuclear power plant leakage in Japan, it is more practical to improve the design capability and product performance of the nuclear power valve. The finite element numerical analysis is a common and effective method for the development of nuclear power valves. Nuclear power valve has high safety, complexity of valve chamber and nonlinearity of seal joint surface. Therefore, it is urgent to establish accurate prediction models for earthquake prediction and seal failure to meet engineering accuracy and calculation conditions. In this paper, a general method of finite element modeling for nuclear power valve assembly and key components is presented, aiming at revealing the characteristics and rules of finite element modeling of nuclear power valves, and putting forward aprecision control strategy for finite element models for nuclear power valve characteristics analysis.

Advanced Space Suit Portable Life Support Subsystem Packaging Design

NASA Technical Reports Server (NTRS)

Howe, Robert; Diep, Chuong; Barnett, Bob; Thomas, Gretchen; Rouen, Michael; Kobus, Jack

2006-01-01

This paper discusses the Portable Life Support Subsystem (PLSS) packaging design work done by the NASA and Hamilton Sundstrand in support of the 3 future space missions; Lunar, Mars and zero-g. The goal is to seek ways to reduce the weight of PLSS packaging, and at the same time, develop a packaging scheme that would make PLSS technology changes less costly than the current packaging methods. This study builds on the results of NASA s in-house 1998 study, which resulted in the "Flex PLSS" concept. For this study the present EMU schematic (low earth orbit) was used so that the work team could concentrate on the packaging. The Flex PLSS packaging is required to: protect, connect, and hold the PLSS and its components together internally and externally while providing access to PLSS components internally for maintenance and for technology change without extensive redesign impact. The goal of this study was two fold: 1. Bring the advanced space suit integrated Flex PLSS concept from its current state of development to a preliminary design level and build a proof of concept mockup of the proposed design, and; 2. "Design" a Design Process, which accommodates both the initial Flex PLSS design and the package modifications, required to accommodate new technology.

How to Study Chronic Diseases-Implications of the Convention on the Rights of Persons with Disabilities for Research Designs.

PubMed

von Peter, Sebastian; Bieler, Patrick

2017-01-01

The Convention on the Rights of Persons with Disabilities (CRPD) has been received considerable attention internationally. The Convention's main arguments are conceptually analyzed. Implications for the development of research designs are elaborated upon. The Convention entails both a human rights and a sociopolitical dimension. Advancing a relational notion of disability, it enters a rather foreign terrain to medical sciences. Research designs have to be changed accordingly. Research designs in accordance with the CRPD should employ and further develop context-sensitive research strategies and interdisciplinary collaboration. Complex designs that allow for a relational analysis of personalized effects have to be established and evaluated, thereby systematically integrating qualitative methods.

Advancing Alternative Analysis: Integration of Decision Science

PubMed Central

Zaunbrecher, Virginia M.; Batteate, Christina M.; Blake, Ann; Carroll, William F.; Corbett, Charles J.; Hansen, Steffen Foss; Lempert, Robert J.; Linkov, Igor; McFadden, Roger; Moran, Kelly D.; Olivetti, Elsa; Ostrom, Nancy K.; Romero, Michelle; Schoenung, Julie M.; Seager, Thomas P.; Sinsheimer, Peter; Thayer, Kristina A.

2017-01-01

Background: Decision analysis—a systematic approach to solving complex problems—offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and viability of potential substitutes for hazardous chemicals. Objectives: We assessed whether decision science may assist the alternatives analysis decision maker in comparing alternatives across a range of metrics. Methods: A workshop was convened that included representatives from government, academia, business, and civil society and included experts in toxicology, decision science, alternatives assessment, engineering, and law and policy. Participants were divided into two groups and were prompted with targeted questions. Throughout the workshop, the groups periodically came together in plenary sessions to reflect on other groups’ findings. Results: We concluded that the further incorporation of decision science into alternatives analysis would advance the ability of companies and regulators to select alternatives to harmful ingredients and would also advance the science of decision analysis. Conclusions: We advance four recommendations: a) engaging the systematic development and evaluation of decision approaches and tools; b) using case studies to advance the integration of decision analysis into alternatives analysis; c) supporting transdisciplinary research; and d) supporting education and outreach efforts. https://doi.org/10.1289/EHP483 PMID:28669940

Advanced 3D mesh manipulation in stereolithographic files and post-print processing for the manufacturing of patient-specific vascular flow phantoms

NASA Astrophysics Data System (ADS)

O'Hara, Ryan P.; Chand, Arpita; Vidiyala, Sowmya; Arechavala, Stacie M.; Mitsouras, Dimitrios; Rudin, Stephen; Ionita, Ciprian N.

2016-03-01

Complex vascular anatomies can cause the failure of image-guided endovascular procedures. 3D printed patient-specific vascular phantoms provide clinicians and medical device companies the ability to preemptively plan surgical treatments, test the likelihood of device success, and determine potential operative setbacks. This research aims to present advanced mesh manipulation techniques of stereolithographic (STL) files segmented from medical imaging and post-print surface optimization to match physiological vascular flow resistance. For phantom design, we developed three mesh manipulation techniques. The first method allows outlet 3D mesh manipulations to merge superfluous vessels into a single junction, decreasing the number of flow outlets and making it feasible to include smaller vessels. Next we introduced Boolean operations to eliminate the need to manually merge mesh layers and eliminate errors of mesh self-intersections that previously occurred. Finally we optimize support addition to preserve the patient anatomical geometry. For post-print surface optimization, we investigated various solutions and methods to remove support material and smooth the inner vessel surface. Solutions of chloroform, alcohol and sodium hydroxide were used to process various phantoms and hydraulic resistance was measured and compared with values reported in literature. The newly mesh manipulation methods decrease the phantom design time by 30 - 80% and allow for rapid development of accurate vascular models. We have created 3D printed vascular models with vessel diameters less than 0.5 mm. The methods presented in this work could lead to shorter design time for patient specific phantoms and better physiological simulations.

Developing knowledge intensive ideas in engineering education: the application of camp methodology

NASA Astrophysics Data System (ADS)

Heidemann Lassen, Astrid; Løwe Nielsen, Suna

2011-11-01

Background: Globalization, technological advancement, environmental problems, etc. challenge organizations not just to consider cost-effectiveness, but also to develop new ideas in order to build competitive advantages. Hence, methods to deliberately enhance creativity and facilitate its processes of development must also play a central role in engineering education. However, so far the engineering education literature provides little attention to the important discussion of how to develop knowledge intensive ideas based on creativity methods and concepts. Purpose: The purpose of this article is to investigate how to design creative camps from which knowledge intensive ideas can unfold. Design/method/sample: A framework on integration of creativity and knowledge intensity is first developed, and then tested through the planning, execution and evaluation of a specialized creativity camp with focus on supply chain management. Detailed documentation of the learning processes of the participating 49 engineering and business students is developed through repeated interviews during the process as well as a survey. Results: The research illustrates the process of development of ideas, and how the participants through interdisciplinary collaboration, cognitive flexibility and joint ownership develop highly innovative and knowledge-intensive ideas, with direct relevance for the four companies whose problems they address. Conclusions: The article demonstrates how the creativity camp methodology holds the potential of combining advanced academic knowledge and creativity, to produce knowledge intensive ideas, when the design is based on ideas of experiential learning as well as creativity principles. This makes the method a highly relevant learning approach for engineering students in the search for skills to both develop and implement innovative ideas.

Advanced 3D Mesh Manipulation in Stereolithographic Files and Post-Print Processing for the Manufacturing of Patient-Specific Vascular Flow Phantoms.

PubMed

O'Hara, Ryan P; Chand, Arpita; Vidiyala, Sowmya; Arechavala, Stacie M; Mitsouras, Dimitrios; Rudin, Stephen; Ionita, Ciprian N

2016-02-27

Complex vascular anatomies can cause the failure of image-guided endovascular procedures. 3D printed patient-specific vascular phantoms provide clinicians and medical device companies the ability to preemptively plan surgical treatments, test the likelihood of device success, and determine potential operative setbacks. This research aims to present advanced mesh manipulation techniques of stereolithographic (STL) files segmented from medical imaging and post-print surface optimization to match physiological vascular flow resistance. For phantom design, we developed three mesh manipulation techniques. The first method allows outlet 3D mesh manipulations to merge superfluous vessels into a single junction, decreasing the number of flow outlets and making it feasible to include smaller vessels. Next we introduced Boolean operations to eliminate the need to manually merge mesh layers and eliminate errors of mesh self-intersections that previously occurred. Finally we optimize support addition to preserve the patient anatomical geometry. For post-print surface optimization, we investigated various solutions and methods to remove support material and smooth the inner vessel surface. Solutions of chloroform, alcohol and sodium hydroxide were used to process various phantoms and hydraulic resistance was measured and compared with values reported in literature. The newly mesh manipulation methods decrease the phantom design time by 30 - 80% and allow for rapid development of accurate vascular models. We have created 3D printed vascular models with vessel diameters less than 0.5 mm. The methods presented in this work could lead to shorter design time for patient specific phantoms and better physiological simulations.

Advanced 3D Mesh Manipulation in Stereolithographic Files and Post-Print Processing for the Manufacturing of Patient-Specific Vascular Flow Phantoms

PubMed Central

O’Hara, Ryan P.; Chand, Arpita; Vidiyala, Sowmya; Arechavala, Stacie M.; Mitsouras, Dimitrios; Rudin, Stephen; Ionita, Ciprian N.

2017-01-01

Complex vascular anatomies can cause the failure of image-guided endovascular procedures. 3D printed patient-specific vascular phantoms provide clinicians and medical device companies the ability to preemptively plan surgical treatments, test the likelihood of device success, and determine potential operative setbacks. This research aims to present advanced mesh manipulation techniques of stereolithographic (STL) files segmented from medical imaging and post-print surface optimization to match physiological vascular flow resistance. For phantom design, we developed three mesh manipulation techniques. The first method allows outlet 3D mesh manipulations to merge superfluous vessels into a single junction, decreasing the number of flow outlets and making it feasible to include smaller vessels. Next we introduced Boolean operations to eliminate the need to manually merge mesh layers and eliminate errors of mesh self-intersections that previously occurred. Finally we optimize support addition to preserve the patient anatomical geometry. For post-print surface optimization, we investigated various solutions and methods to remove support material and smooth the inner vessel surface. Solutions of chloroform, alcohol and sodium hydroxide were used to process various phantoms and hydraulic resistance was measured and compared with values reported in literature. The newly mesh manipulation methods decrease the phantom design time by 30 – 80% and allow for rapid development of accurate vascular models. We have created 3D printed vascular models with vessel diameters less than 0.5 mm. The methods presented in this work could lead to shorter design time for patient specific phantoms and better physiological simulations. PMID:28649165

Development of Advanced Life Cycle Costing Methods for Technology Benefit/Cost/Risk Assessment

NASA Technical Reports Server (NTRS)

Yackovetsky, Robert (Technical Monitor)

2002-01-01

The overall objective of this three-year grant is to provide NASA Langley's System Analysis Branch with improved affordability tools and methods based on probabilistic cost assessment techniques. In order to accomplish this objective, the Aerospace Systems Design Laboratory (ASDL) needs to pursue more detailed affordability, technology impact, and risk prediction methods and to demonstrate them on variety of advanced commercial transports. The affordability assessment, which is a cornerstone of ASDL methods, relies on the Aircraft Life Cycle Cost Analysis (ALCCA) program originally developed by NASA Ames Research Center and enhanced by ASDL. This grant proposed to improve ALCCA in support of the project objective by updating the research, design, test, and evaluation cost module, as well as the engine development cost module. Investigations into enhancements to ALCCA include improved engine development cost, process based costing, supportability cost, and system reliability with airline loss of revenue for system downtime. A probabilistic, stand-alone version of ALCCA/FLOPS will also be developed under this grant in order to capture the uncertainty involved in technology assessments. FLOPS (FLight Optimization System program) is an aircraft synthesis and sizing code developed by NASA Langley Research Center. This probabilistic version of the coupled program will be used within a Technology Impact Forecasting (TIF) method to determine what types of technologies would have to be infused in a system in order to meet customer requirements. A probabilistic analysis of the CER's (cost estimating relationships) within ALCCA will also be carried out under this contract in order to gain some insight as to the most influential costs and the impact that code fidelity could have on future RDS (Robust Design Simulation) studies.

MINIVER upgrade for the AVID system. Volume 1: LANMIN user's manual

NASA Technical Reports Server (NTRS)

Engel, C. D.; Praharaj, S. C.

1983-01-01

The successful design of thermal protection systems for vehicles operating in atmosphere and near space environments requires accurate analyses of heating rate and temperature histories encountered along a trajectory. For preliminary design calculations, however, the requirement for accuracy must be tempered by the need for speed and versatility in computational tools used to determine thermal environments and structural thermal response. The MINIVER program has been found to provide the proper balance between versatility, speed and accuracy for an aerothermal prediction tool. The advancement in computer aided design concepts at Langley Research Center (LaRC) in the past few years has made it desirable to incorporate the MINIVER program into the LaRC Advanced Vehicle Integrated Design, AVID, system. In order to effectively incorporate MINIVER into the AVID system, several changes to MINIVER were made. The thermal conduction options in MINIVER were removed and a new Explicit Interactive Thermal Structures (EXITS) code was developed. Many upgrades to the MINIVER code were made and a new Langley version of MINIVER called LANMIN was created. The theoretical methods and subroutine functions used in LANMIN are described.

Advanced instrumentation for aircraft icing research

NASA Technical Reports Server (NTRS)

Bachalo, W.; Smith, J.; Rudoff, R.

1990-01-01

A compact and rugged probe based on the phase Doppler method was evaluated as a means for characterizing icing clouds using airborne platforms and for advancing aircraft icing research in large scale wind tunnels. The Phase Doppler Particle Analyzer (PDPA) upon which the new probe was based is now widely recognized as an accurate method for the complete characterization of sprays. The prototype fiber optic-based probe was evaluated in simulated aircraft icing clouds and found to have the qualities essential to providing information that will advance aircraft icing research. Measurement comparisons of the size and velocity distributions made with the standard PDPA and the fiber optic probe were in excellent agreement as were the measurements of number density and liquid water content. Preliminary testing in the NASA Lewis Icing Research Tunnel (IRT) produced reasonable results but revealed some problems with vibration and signal quality at high speeds. The cause of these problems were identified and design changes were proposed to eliminate the shortcomings of the probe.

Behavioral science and the study of gene-nutrition and gene-physical activity interactions in obesity research.

PubMed

Faith, Myles S

2008-12-01

This report summarizes emerging opportunities for behavioral science to help advance the field of gene-environment and gene-behavior interactions, based on presentations at The National Cancer Institute (NCI) Workshop, "Gene-Nutrition and Gene-Physical Activity Interactions in the Etiology of Obesity." Three opportunities are highlighted: (i) designing potent behavioral "challenges" in experiments, (ii) determining viable behavioral phenotypes for genetics studies, and (iii) identifying specific measures of the environment or environmental exposures. Additional points are underscored, including the need to incorporate novel findings from neuroimaging studies regarding motivation and drive for eating and physical activity. Advances in behavioral science theory and methods can play an important role in advancing understanding of gene-brain-behavior relationships in obesity onset.

Predicted changes in advanced turboprop noise with shaft angle of attack

NASA Technical Reports Server (NTRS)

Padula, S. L.; Block, P. J. W.

1984-01-01

Advanced turboprop blade designs and new propeller installation schemes motivated an effort to include unsteady loading effects in existing propeller noise prediction computer programs. The present work validates the prediction capability while studing the effects of shaft inclination on the radiated sound field. Classical methods of propeller performance analysis supply the time-dependent blade loading needed to calculate noise. Polar plots of the sound pressure level (SPL) of the first four harmonics and overall SPL are indicative of the change in directivity pattern as a function of propeller angle of attack. Noise predictions are compared with newly available wind tunnel data and the accuracy and applicability of the prediction method are discussed. It is concluded that unsteady blade loading caused by inclining the propeller with respect to the flow changes the directionality and the intensity of the radiated noise. These changes are well modeled by the present quasi-steady prediction method.

Advanced Chemical Propulsion

NASA Technical Reports Server (NTRS)

Bai, S. Don

2000-01-01

Design, propellant selection, and launch assistance for advanced chemical propulsion system is discussed. Topics discussed include: rocket design, advance fuel and high energy density materials, launch assist, and criteria for fuel selection.

A Design Heritage-Based Forecasting Methodology for Risk Informed Management of Advanced Systems

NASA Technical Reports Server (NTRS)

Maggio, Gaspare; Fragola, Joseph R.

1999-01-01

The development of next generation systems often carries with it the promise of improved performance, greater reliability, and reduced operational costs. These expectations arise from the use of novel designs, new materials, advanced integration and production technologies intended for functionality replacing the previous generation. However, the novelty of these nascent technologies is accompanied by lack of operational experience and, in many cases, no actual testing as well. Therefore some of the enthusiasm surrounding most new technologies may be due to inflated aspirations from lack of knowledge rather than actual future expectations. This paper proposes a design heritage approach for improved reliability forecasting of advanced system components. The basis of the design heritage approach is to relate advanced system components to similar designs currently in operation. The demonstrated performance of these components could then be used to forecast the expected performance and reliability of comparable advanced technology components. In this approach the greater the divergence of the advanced component designs from the current systems the higher the uncertainty that accompanies the associated failure estimates. Designers of advanced systems are faced with many difficult decisions. One of the most common and more difficult types of these decisions are those related to the choice between design alternatives. In the past decision-makers have found these decisions to be extremely difficult to make because they often involve the trade-off between a known performing fielded design and a promising paper design. When it comes to expected reliability performance the paper design always looks better because it is on paper and it addresses all the know failure modes of the fielded design. On the other hand there is a long, and sometimes very difficult road, between the promise of a paper design and its fulfillment; with the possibility that sometimes the reliability promise is not fulfilled at all. Decision makers in advanced technology areas have always known to discount the performance claims of a design to a degree in proportion to its stage of development, and at times have preferred the more mature design over the one of lesser maturity even with the latter promising substantially better performance once fielded. As with the broader measures of performance this has also been true for projected reliability performance. Paper estimates of potential advances in design reliability are to a degree uncertain in proportion to the maturity of the features being proposed to secure those advances. This is especially true when performance-enhancing features in other areas are also planned to be part of the development program.

Everyday Physical Activity as a Predictor of Late-Life Mortality

ERIC Educational Resources Information Center

Chipperfield, Judith G.

2008-01-01

Purpose: The present study hypothesized that simple, everyday physical activity (EPA) would decline with advancing age; that women would have a more favorable EPA profile than would men; and that EPA would have a survival benefit. Design and Methods: Community-dwelling participants (aged 80-98 years, n = 198) wore mechanical actigraphs in order…

"Just Having a Job": Career Advancement for Low-Wage Workers with Intellectual and Developmental Disabilities

ERIC Educational Resources Information Center

Lindstrom, Lauren; Hirano, Kara A.; McCarthy, Colleen; Alverson, Charlotte Y.

2014-01-01

This study examined career development and early employment experiences for four young adults with intellectual and developmental disabilities. Researchers used a multiple-method, multiple case-study longitudinal design to explore career development within the context of family systems, high school and transition programs, adult services, and…

Reconstructing Readability: Recent Developments and Recommendations in the Analysis of Text Difficulty

ERIC Educational Resources Information Center

Benjamin, Rebekah George

2012-01-01

Largely due to technological advances, methods for analyzing readability have increased significantly in recent years. While past researchers designed hundreds of formulas to estimate the difficulty of texts for readers, controversy has surrounded their use for decades, with criticism stemming largely from their application in creating new texts…

Advanced Entry Adult Apprenticeship Training Scheme: A Case Study

ERIC Educational Resources Information Center

Sparks, Alan; Ingram, Hadyn; Phillips, Sunny

2009-01-01

Purpose: The purpose of this paper is to evaluate an innovative way to train adult apprentices for the construction industry. Design/methodology/approach: The paper emphasizes that, in order to address skills shortages for international construction, training methods must be improved. It looks at the example of an adult apprenticeship scheme in…

Effective Teaching in Elementary Social Studies.

ERIC Educational Resources Information Center

Savage, Tom V.; Armstrong, David G.

This book is designed for use in elementary social studies methods classes, as a source for discussion in advanced curriculum classes, and as a personal reference for elementary social studies teachers. This book has four major divisions with each division offering a list of lesson ideas. Part 1, "Contexts for the Social Studies," includes: (1)…

Preparation and Analysis of Solid Solutions in the Potassium Perchlorate-Permanganate System.

ERIC Educational Resources Information Center

Johnson, Garrett K.

1979-01-01

Describes an experiment, designed for and tested in an advanced inorganic laboratory methods course for college seniors and graduate students, that prepares and analyzes several samples in the nearly ideal potassium perchlorate-permanganate solid solution series. The results are accounted for by a theoretical treatment based upon aqueous…

Advanced imaging techniques III: a scalable and modular dome illumination system for scientific microphotography on a budget

USDA-ARS?s Scientific Manuscript database

A scalable and modular LED illumination dome for microscopic scientific photography is described and illustrated, and methods for constructing such a dome are detailed. Dome illumination for insect specimens has become standard practice across the field of insect systematics, but many dome designs ...

Comparing Interaction and Use of Space in Traditional and Innovative Classrooms

ERIC Educational Resources Information Center

Gurzynski-Weiss, Laura; Long, Avizia Y.; Solon, Megan

2015-01-01

Despite myriad changes to language teaching methods over time, university-level classroom spaces have largely remained the same--until now. Recent innovations in classroom space design center on technological advances, include movable furniture and coffee-shop style rooms, and are believed to facilitate language learning in several ways.…

Advanced Methods for Aircraft Engine Thrust and Noise Benefits: Nozzle-Inlet Flow Analysis

NASA Technical Reports Server (NTRS)

Morgan, Morris H.; Gilinsky, Mikhail; Patel, Kaushal; Coston, Calvin; Blankson, Isaiah M.

2003-01-01

The research is focused on a wide regime of problems in the propulsion field as well as in experimental testing and theoretical and numerical simulation analyses for advanced aircraft and rocket engines. Results obtained are based on analytical methods, numerical simulations and experimental tests at the NASA LaRC and Hampton University computer complexes and experimental facilities. The main objective of this research is injection, mixing and combustion enhancement in propulsion systems. The sub-projects in the reporting period are: (A) Aero-performance and acoustics of Telescope-shaped designs. The work included a pylon set application for SCRAMJET. (B) An analysis of sharp-edged nozzle exit designs for effective fuel injection into the flow stream in air-breathing engines: triangular-round and diamond-round nozzles. (C) Measurement technique improvements for the HU Low Speed Wind Tunnel (HU LSWT) including an automatic data acquisition system and a two component (drag-lift) balance system. In addition, a course in the field of aerodynamics was developed for the teaching and training of HU students.

Advancing tuberculosis drug regimen development through innovative quantitative translational pharmacology methods and approaches.

PubMed

Hanna, Debra; Romero, Klaus; Schito, Marco

2017-03-01

The development of novel tuberculosis (TB) multi-drug regimens that are more efficacious and of shorter duration requires a robust drug development pipeline. Advances in quantitative modeling and simulation can be used to maximize the utility of patient-level data from prior and contemporary clinical trials, thus optimizing study design for anti-TB regimens. This perspective article highlights the work of seven project teams developing first-in-class translational and quantitative methodologies that aim to inform drug development decision-making, dose selection, trial design, and safety assessments, in order to achieve shorter and safer therapies for patients in need. These tools offer the opportunity to evaluate multiple hypotheses and provide a means to identify, quantify, and understand relevant sources of variability, to optimize translation and clinical trial design. When incorporated into the broader regulatory sciences framework, these efforts have the potential to transform the development paradigm for TB combination development, as well as other areas of global health. Copyright © 2016. Published by Elsevier Ltd.