The Youngest Minds: Parenting and Genes in the Development of Intellect and Emotion.

ERIC Educational Resources Information Center

Barnet, Ann B.; Barnet, Richard J.

Noting that recent advances in neuroscience and psychology make it possible to understand more clearly how parents help to shape their children's brain development, this book discusses what is becoming known about how young children acquire language, develop emotional ties, gain control of their own emotions, become able to experience the joy and…

In vivo miniature robots for natural orifice surgery: State of the art and future perspectives.

PubMed

Tiwari, Manish M; Reynoso, Jason F; Lehman, Amy C; Tsang, Albert W; Farritor, Shane M; Oleynikov, Dmitry

2010-06-27

Natural orifice translumenal endoscopic surgery (NOTES) is the integration of laparoscopic minimally invasive surgery techniques with endoscopic technology. Despite the advances in NOTES technology, the approach presents several unique instrumentation and technique-specific challenges. Current flexible endoscopy platforms for NOTES have several drawbacks including limited stability, triangulation and dexterity, and lack of adequate visualization, suggesting the need for new and improved instrumentation for this approach. Much of the current focus is on the development of flexible endoscopy platforms that incorporate robotic technology. An alternative approach to access the abdominal viscera for either a laparoscopic or NOTES procedure is the use of small robotic devices that can be implanted in an intracorporeal manner. Multiple, independent, miniature robots can be simultaneously inserted into the abdominal cavity to provide a robotic platform for NOTES surgery. The capabilities of the robots include imaging, retraction, tissue and organ manipulation, and precise maneuverability in the abdominal cavity. Such a platform affords several advantages including enhanced visualization, better surgical dexterity and improved triangulation for NOTES. This review discusses the current status and future perspectives of this novel miniature robotics platform for the NOTES approach. Although these technologies are still in pre-clinical development, a miniature robotics platform provides a unique method for addressing the limitations of minimally invasive surgery, and NOTES in particular.

Molecular ferroelectrics: where electronics meet biology

PubMed Central

Li, Jiangyu; Liu, Yuanming; Zhang, Yanhang; Cai, Hong-Ling; Xiong, Ren-Gen

2013-01-01

In the last several years, we have witnessed significant advances in molecular ferroelectrics, with ferroelectric properties of molecular crystals approaching those of barium titanate. In addition, ferroelectricity has been observed in biological systems, filling an important missing link in bioelectric phenomena. In this perspective, we will present short historical notes on ferroelectrics, followed by overview on the fundamentals of ferroelectricity. Latest development in molecular ferroelectrics and biological ferroelectricity will then be highlighted, and their implications and potential applications will be discussed. We close by noting molecular ferroelectric as an exciting frontier between electronics and biology, and a number of challenges ahead are also noted. PMID:24018952

Education Matters, December 2009

ERIC Educational Resources Information Center

Beckner, Gary, Ed.

2009-01-01

"Education Matters" is the monthly newsletter of the Association of American Educators (AAE), an organization dedicated to advancing the American teaching profession through personal growth, professional development, teacher advocacy and protection. This issue of the newsletter includes: (1) Notes from the Front Lines: Study Reveals…

The current status of neoadjuvant therapy for esophageal cancer.

PubMed

Lin, Daniel; Leichman, Lawrence

2014-01-01

Through the contribution of a very large number of single-arm phase II trials and many less randomized phase III trials, the standard of care for locally advanced esophageal cancer has evolved to either combination chemotherapy plus radiation or combination chemotherapy. In this review, we focus on the key findings of these studies and selected meta-analyses that have led to this evolution. We note differences in outcomes for adenocarcinomas of the esophagus when compared to squamous cell esophageal cancers. Despite progress in developing a consensus for therapy, the outcome for patients with locally advanced remains poor. We complete the review by noting newer areas of investigation seeking to provide targeted and more personalized therapy to patients with esophageal cancer. Copyright © 2014 Elsevier Inc. All rights reserved.

20 Years of Research into Violence and Trauma: Past and Future Developments

ERIC Educational Resources Information Center

Kamphuis, Jan H.; Emmelkamp, Paul M. G.

2005-01-01

This reflection on major developments in the past, present, and future of the wider field of violence and trauma is a personal (and probably biased) sampling of what the authors hold to be important. The authors reviewed advances for victims and perpetrators of violence separately. For victims, the authors note that empirical research has…

Training on N.O.T.E.S.: from history we learn.

PubMed

Al-Akash, M; Boyle, E; Tanner, W A

2009-06-01

Surgical errors occurring early in the learning curve of laparoscopic surgery providers delayed the uptake and progress of minimally invasive surgery (MIS) for years. This taught us a valuable lesson; innovations in surgical techniques should not be rapidly implemented until all aspects including applicability, feasibility and safety have been fully tested. In 2005, the Natural Orifice Surgery Consortium for Assessment and Research (NOSCAR) published a white paper highlighting the barriers to NOTES development and identifying key elements for its progress. One of these elements is the training of future providers. Proficiency-based, virtual reality simulation will offer a feasible alternative to animal testing once the safety and efficacy parameters of NOTES are established. Recent advances in imaging including computed tomography (CT) scanning, magnetic resonance imaging (MRI) scanning, and ultrasound (US) scanning can offer improved image registration and real-time tracking. Combining these advanced imaging technologies with the newly designed virtual reality simulators will result in a fully comprehensive simulation curriculum which will offer a unique facility for future NOTES providers to train anytime, anywhere, and as much as they need to in order to achieve the pre-set proficiency levels for a variety of NOTES procedures. Furthermore they will incorporate patient-specific anatomical models obtained from patient imaging and uploaded onto the simulator to ensure face reliability and validity assurance. Training in a clean, safe environment with proximate feedback and performance analysis will help accelerate the learning curve and therefore improve patients' safety and outcomes in order to maximize the benefits of innovative access procedures such as NOTES.

Advancing Home-School Relations through Parent Support?

ERIC Educational Resources Information Center

Bergnehr, Disa

2015-01-01

The present study explores a local initiative to develop parent support services through the school system. In focus are the discourse on home-school relations and parent support and the interplay between discourse and practical occurrences. Official documents, interviews and notes from municipal meetings and informal conversations were obtained…

Spanish Language Workbook (In Development).

ERIC Educational Resources Information Center

Peace Corps, Santiago (Chile).

This guide is designed for the Spanish language training of Peace Corps workers in Chile and reflects daily communication needs in that context. The workbook contains a series of sentence completion exercises at the intermediate to advanced level, notes and exercises on metric system conversion, verb/substantive lists, specialized vocabulary lists…

Advancements in Curricular Design: Web-Assisted Courseware Applications in Mass Communication.

ERIC Educational Resources Information Center

Reppert, James E.

Interactive courseware applications are becoming more prevalent as instructional tools in the communication classroom. Prometheus, developed by George Washington University, allows instructors to post syllabi, course outlines, lecture notes, and tests online, in addition to giving students access to discussions and chat sessions. Other popular…

Application of Advanced Signal Processing Techniques to Angle of Arrival Estimation in ATC Navigation and Surveillance Systems

DTIC Science & Technology

1982-06-23

Administration Systems Research and Development Service 14, Spseq Aese Ce ’ Washington, D.C. 20591 It. SeppkW•aae metm The work reported in this document was...consider sophisticated signal processing techniques as an alternative method of improving system performanceH Some work in this area has already taken place...demands on the frequency spectrum. As noted in Table 1-1, there has been considerable work on advanced signal processing in the MLS context

Twitter and Physics Professional Development

NASA Astrophysics Data System (ADS)

Nadji, Taoufik

2016-11-01

The advent of Twitter® and other social media services of its type ushered in a new era of professional development in education. This article addresses how a group of users have been employing Twitter to conduct professional development sessions that would benefit their participants by advancing their pedagogical approaches to learning and teaching physics. The diversity within this group is something to both note and celebrate because it includes minorities, women, and physics educators the world over.

Survey Review of Materials for Teaching Advanced Listening and Note-Taking.

ERIC Educational Resources Information Center

Hamp-Lyons, Elizabeth

Eight commercially-available listening and note-taking courses are reviewed and a matrix for comparing their characteristics is presented. "Listening and Note-Taking" (Virginia Yates) was written for college-bound high school students and college students who need to improve listening and note-taking skills, while the "Sack-Yourman Study Skills…

Development of improved coating for advanced carbon-carbon components

NASA Technical Reports Server (NTRS)

Yamaki, Y. R.; Brown, J. J.

1984-01-01

Reaction sintered silicon nitride (RSSN) was studied as a substitute coating material on the carbon-carbon material (RCC) presently used as a heat shield on the space shuttle, and on advanced carbon-carbon (ACC), a later development. On RCC, RSSN showed potential in a 538 C (1000 F) screening test in which silicon carbide coated material exhibits its highest oxidation rate; RSSN afforded less protection to ACC because of a larger thermal expansion mismatch. Organosilicon densification and metallic silicon sealing methods were studied as means of further increasing the oxidation resistance of the coating, and some improvement was noted when these methods were employed.

Using Concept Maps in Political Science

ERIC Educational Resources Information Center

Chamberlain, Robert P.

2015-01-01

Concept mapping is a pedagogical technique that was developed in the 1970s and is being used in K-12 and postsecondary education. Although it has shown excellent results in other fields, it is still rare in political science. In this research note, I discuss the implementation and testing of concept mapping in my Advanced Introduction to…

An Overview of Assessment and Treatment of Premenstrual Syndrome.

ERIC Educational Resources Information Center

Neimeyer, Greg J.; Kosch, Shae Graham

1988-01-01

Notes that premenstrual syndrome (PMS) is a commonly occurring problem that must be dealt with by both the helping and the health professions. Provides a brief update on recent advances in understanding and treating PMS. Emphasizes points of contact among various health professionals in developing an interdisciplinary approach to intervention.…

An Overview of the History of Orthopedic Surgery.

PubMed

Swarup, Ishaan; O'Donnell, Joseph F

Orthopedic surgery has a long and rich history. While the modern term orthopedics was coined in the 1700s, orthopedic principles were beginning to be developed and used during primitive times. The Egyptians continued these practices, and described ways to recognize and manage common orthopedic conditions. The Greeks and Romans subsequently began to study medicine in a systematic manner, and greatly improved our understanding of orthopedic anatomy and surgical technique. After a period of little progress during the Middle Ages, rapid advancement was noted during the Renaissance, including the description of various injuries, improvements in surgical technique, and development of orthopedic hospitals. Collectively, these advances provided the foundation for modern orthopedics. Currently, orthopedic surgery is a rapidly developing field that has benefited from the works of numerous scholars and surgeons. It is important to recognize the successes and failures of the past, in order to advance research and practice as well as improve patient care and clinical outcomes.

Advanced composites technology program

NASA Technical Reports Server (NTRS)

Davis, John G., Jr.

1993-01-01

This paper provides a brief overview of the NASA Advanced Composites Technology (ACT) Program. Critical technology issues that must be addressed and solved to develop composite primary structures for transport aircraft are delineated. The program schedule and milestones are included. Work completed in the first 3 years of the program indicates the potential for achieving composite structures that weigh less and are cost effective relative to conventional aluminum structure. Selected technical accomplishments are noted. Readers who are seeking more in-depth technical information should study the other papers included in these proceedings.

Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria.

PubMed

Plebanski, Magdalena; Lopez, Ester; Proudfoot, Owen; Cooke, Brian M; Itzstein, Mark von; Coppel, Ross L

2006-09-01

Herein, we analyze in general the current vaccine market and identify potential factors driving and modulating supply and demand for vaccines. An emphasis is placed on changes in regulation in the last 20 years which have led to increased indirect costs of production, and which can create a barrier against the timely use of technological advances to reduce direct costs. Other defining industry characteristics, such as firm numbers and sizes, cost and pricing strategies, nature extent and impact of Government involvement and international regulation are noted. These considerations, far from being removed from basic vaccine research, influence its ability to achieve aims that can be then progressed into effective vaccine products. We discuss specifically the development of particulate vaccines against malaria, a major lethal disease and health problem prevalent in Africa, including some key economic and methodological challenges and opportunities. We note some practical issues blocking the development of effective particulate vaccines for the Third World, mainly driven by the regulatory spiral noted above.

The development of Human Functional Brain Networks

PubMed Central

Power, Jonathan D; Fair, Damien A; Schlaggar, Bradley L

2010-01-01

Recent advances in MRI technology have enabled precise measurements of correlated activity throughout the brain, leading to the first comprehensive descriptions of functional brain networks in humans. This article reviews the growing literature on the development of functional networks, from infancy through adolescence, as measured by resting state functional connectivity MRI. We note several limitations of traditional approaches to describing brain networks, and describe a powerful framework for analyzing networks, called graph theory. We argue that characterization of the development of brain systems (e.g. the default mode network) should be comprehensive, considering not only relationships within a given system, but also how these relationships are situated within wider network contexts. We note that, despite substantial reorganization of functional connectivity, several large-scale network properties appear to be preserved across development, suggesting that functional brain networks, even in children, are organized in manners similar to other complex systems. PMID:20826306

Computational aerodynamics development and outlook /Dryden Lecture in Research for 1979/

NASA Technical Reports Server (NTRS)

Chapman, D. R.

1979-01-01

Some past developments and current examples of computational aerodynamics are briefly reviewed. An assessment is made of the requirements on future computer memory and speed imposed by advanced numerical simulations, giving emphasis to the Reynolds averaged Navier-Stokes equations and to turbulent eddy simulations. Experimental scales of turbulence structure are used to determine the mesh spacings required to adequately resolve turbulent energy and shear. Assessment also is made of the changing market environment for developing future large computers, and of the projections of micro-electronics memory and logic technology that affect future computer capability. From the two assessments, estimates are formed of the future time scale in which various advanced types of aerodynamic flow simulations could become feasible. Areas of research judged especially relevant to future developments are noted.

Speed and Accuracy of Absolute Pitch Judgments: Some Latter-Day Results.

ERIC Educational Resources Information Center

Carroll, John B.

Nine subjects, 5 of whom claimed absolute pitch (AP) ability were instructed to rapidly strike notes on the piano to match randomized tape-recorded piano notes. Stimulus set sizes were 64, 16, or 4 consecutive semitones, or 7 diatonic notes of a designated octave. A control task involved motor movements to notes announced in advance. Accuracy,…

Assessing and Advocating for Gifted Students: Perspectives for School and Clinical Psychologists. Senior Scholars Series.

ERIC Educational Resources Information Center

Robinson, Nancy M.

This monograph summarizes research about the assessment of academically gifted students and addresses the kinds of advocacy a psychologist can offer. The components of a comprehensive assessment are described, noting that many tests developed for the age or grade of gifted students will fail to reflect their advanced abilities and skills.…

Developing Deep Understanding and Literacy while Addressing a Gender-Based Literacy Gap

ERIC Educational Resources Information Center

Sun, Yanqing; Zhang, Jianwei; Scardamalia, Marlene

2010-01-01

Online discourse from a class of 22 students (11 boys and 11 girls) was analysed to assess advances in conceptual understanding and literacy. The students worked over a two-year period (Grades 3-4), during which they contributed notes to an online Knowledge Building environment--Knowledge Forum[R]. Contributions revealed that both boys and girls…

FY 1991 RDT&E Descriptive Summaries

DTIC Science & Technology

1990-01-01

OF PROJECT : The Defense Sciences program element provides the technical foundation for long-term improvements in military equiment...DESCRIPTION OF PROJECT : Develop the fundamental technology in advanced digital structures and network concepts for smaller, more powerful, less expensive...DESCRIPTION OF PROJECT : The 1985 Defense Science Board (DSB) noted that the United States was behind and failing further behind in armor and

Note: thermal imaging enhancement algorithm for gas turbine aerothermal characterization.

PubMed

Beer, S K; Lawson, S A

2013-08-01

An algorithm was developed to convert radiation intensity images acquired using a black and white CCD camera to thermal images without requiring knowledge of incident background radiation. This unique infrared (IR) thermography method was developed to determine aerothermal characteristics of advanced cooling concepts for gas turbine cooling application. Compared to IR imaging systems traditionally used for gas turbine temperature monitoring, the system developed for the current study is relatively inexpensive and does not require calibration with surface mounted thermocouples.

NOTES: Issues and Technical Details With Introduction of NOTES Into a Small General Surgery Residency Program

PubMed Central

Mirza, Brian; Horne, Walter; Moskowitz, Jesse B.

2008-01-01

Background and Objectives: Natural orifice translumenal endoscopic surgery (NOTES) is a development of recent origin. In 2004, Kalloo et al first described NOTES investigation in an animal model. Since then, several investigators have pursued NOTES study in animal survival and nonsurvival models. Our objectives for this project included studying NOTES intervention in a laboratory environment using large animal (swine) models and learning to do so in a safe, controlled manner. Ultimately, we intend to introduce NOTES methodology into our surgical residency training program. The expertise of an experienced laparoscopic surgeon, fellowship-trained laparoendoscopic surgeon, and veterinarian along with a senior surgical resident was utilized to bring the input of several disciplines to this study. The Institutional Animal Care and Use Committee (IACUC) of Northeastern Ohio Universities College of Medicine and Pharmacy (NEOUCOM/COP) approved this study. Methods: A series of 5 laboratory sessions using mixed breed farm swine varying in weight from 37 kg to 43.1 kg was planned for the initial phase of NOTES introduction into our residency program. Animals were not kept alive in this investigation. All animals were anesthetized using a standard swine protocol and euthanized following guidelines issued by the American Veterinary Medical Association Panel on Euthanasia. Equipment included a Fujinon EVE endoscope 0.8 cm in diameter with a suction/irrigation channel and one working channel. Initially, a US Endoscopy gastric overtube, 19.5 mm OD and 50 cm in length, was used to facilitate passage of the endoscope. However, this device was found to have insufficient length. Subsequently, commercially available 5/8” diameter clear plastic tubing, 70 cm to 80 cm in length, was adapted for use as an overtube. Standard endoscopic instruments included Boston Scientific biopsy forceps, needle-knife, papillotome, endoscopic clip applier, and Valley Lab electrosurgical unit. A Karl Storz laparoscope and tower were used for laparoscopic observation of NOTES maneuvers. Necropsy was performed to determine specific details of surgical intervention. Results: NOTES intervention is feasible in an animal model. Insight into the potential of NOTES was obtained in this investigation. Conclusions: NOTES investigation in a controlled, laboratory setting using an animal model proved to have value for our program. A steep learning curve was encountered despite the availability of an investigator familiar with elementary NOTES procedures. The authors strongly suggest investigators adopt the ASGE/SAGES working group recommendations for a multidisciplinary team possessing advanced therapeutic endoscopic and advanced laparoscopic skills to study NOTES before human investigation. Animal laboratory facilities to perform research and training should be available to the multidisciplinary team for exploration of NOTES techniques and procedures. Institutional Review Board (IRB) approval must be obtained before introduction of NOTES procedures in human patients. PMID:18402737

7 CFR 3550.206 - Protective advances.

Code of Federal Regulations, 2010 CFR

2010-01-01

... obtain a subsequent loan. (c) Repayment arrangements. (1) Advances for borrowers with multiple loans will be charged against the largest loan. (2) Amounts advanced will be due with the next scheduled payment...) Advances will bear interest at the promissory note rate of the loan to which the advance was charged. ...

7 CFR 4287.156 - Protective advances.

Code of Federal Regulations, 2010 CFR

2010-01-01

... preserves collateral and recovery is actually enhanced by making the advance. Protective advances will not...) Protective advances and interest thereon at the note rate will be guaranteed at the same percentage of loss... 7 Agriculture 15 2010-01-01 2010-01-01 false Protective advances. 4287.156 Section 4287.156...

Molecular ferroelectrics: where electronics meet biology.

PubMed

Li, Jiangyu; Liu, Yuanming; Zhang, Yanhang; Cai, Hong-Ling; Xiong, Ren-Gen

2013-12-28

In the last several years, we have witnessed significant advances in molecular ferroelectrics, with the ferroelectric properties of molecular crystals approaching those of barium titanate. In addition, ferroelectricity has been observed in biological systems, filling an important missing link in bioelectric phenomena. In this perspective, we will present short historical notes on ferroelectrics, followed by an overview of the fundamentals of ferroelectricity. The latest developments in molecular ferroelectrics and biological ferroelectricity will then be highlighted, and their implications and potential applications will be discussed. We close by noting molecular ferroelectric as an exciting frontier between electronics and biology, and a number of challenges ahead are also described.

Addressing Achievement Gaps: Advancing Success for Black Men in College. Policy Notes. Volume 22, Number 1, Spring 2015

ERIC Educational Resources Information Center

Yaffe, Deborah

2015-01-01

This issue of ETS Policy Notes (Vol. 22, No. 1) provides highlights from a recent symposium sponsored by ETS and the Children Defense Fund (CDF), "Advancing Success for Black Men in College," held on June 23, 2014, in Washington, DC. The symposium is part of a two-conference series: It was the 18th of ETS's "Addressing Achievement…

Creating Violence-Free Families: A Symposium Summary Report (New York, New York, May 23-25, 1994).

ERIC Educational Resources Information Center

Friedman, Sara Ann

Noting that family violence is a global and pernicious problem, this report summarizes a symposium--sponsored by the Baha'i International Community's office for the Advancement of Women, in collaboration with the United Nations Children's Fund (UNICEF) and the United Nations Development Fund for Women--on meeting the challenge of and raising…

High Tech Decision Making in the Airpower Age

DTIC Science & Technology

1995-05-01

Note (About Question 1): Current World "All possible question(issues) for further breakup" Break up of the former Soviet Union Megatrends ...nukes, chemical & biological weapons) - also delivery vehicles (for sale on the open market) - advanced conventional weaponry - active/passive...costly to enemy in terms of rebuilding infrastructure, equipment -need to develop countermeasure -may violate the Biological Weapons convention

Case Study: Mini-Case Studies: Small Infusions of Active Learning for Large-Lecture Courses

ERIC Educational Resources Information Center

Carloye, Lisa

2017-01-01

In this article, the author introduces the usage of case studies to be an excellent method for engaging students through stories. The author notes she developed a series of mini-case studies that can be implemented, with a little advance preparation, within a 10- to 15-minute window during lecture. What makes them "mini" case studies?…

On the Pursuit of Sound Science for the Betterment of the American Indian Community: Reply to Beals et al

PubMed Central

Spillane, Nichea S.; Smith, Gregory T.

2009-01-01

We argue that ongoing criticism of existing theories, the development of alternative theories, and empirical theory tests offer the best chance for advancing American Indian research. We, therefore note our appreciation for Beals et al.'s comments. We nevertheless did disagree with many of Beals et al.'s specific claims, noting that (a) our characterization of the existing literature on reservation-dwelling American Indian drinking was accurate; (b) no argument made by Beals et al. undermines their theoretical contention that there is a relative lack of contingency between access to basic life reinforcers and sobriety on many reservations; (c) our theory was developed in a responsible manner: a reservation-tied American Indian developed the theory, which was reviewed by a reservation leadership team, a cultural consultant, and reviewers for this journal, at least one of whom consulted leaders of other reservations; and (d) our theory was based on previous interdisciplinary theory development. We encourage the development and testing of new, alternative theories. PMID:20160843

On the Pursuit of Sound Science for the Betterment of the American Indian Community: Reply to Beals et al.

PubMed

Spillane, Nichea S; Smith, Gregory T

2009-03-01

We argue that ongoing criticism of existing theories, the development of alternative theories, and empirical theory tests offer the best chance for advancing American Indian research. We, therefore note our appreciation for Beals et al.'s comments. We nevertheless did disagree with many of Beals et al.'s specific claims, noting that (a) our characterization of the existing literature on reservation-dwelling American Indian drinking was accurate; (b) no argument made by Beals et al. undermines their theoretical contention that there is a relative lack of contingency between access to basic life reinforcers and sobriety on many reservations; (c) our theory was developed in a responsible manner: a reservation-tied American Indian developed the theory, which was reviewed by a reservation leadership team, a cultural consultant, and reviewers for this journal, at least one of whom consulted leaders of other reservations; and (d) our theory was based on previous interdisciplinary theory development. We encourage the development and testing of new, alternative theories.

Development of Advanced Technologies for Complete Genomic and Proteomic Characterization of Quantized Human Tumor Cells

DTIC Science & Technology

2013-07-01

AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT With the establishment of GBM cell lines...and quantized cell populations form these GBM patients tumor samples we are able to complete some of our aims of our project. We will continue to...collect tumor samples with consent from families of GBM patients in preparation to perform the molecular analysis of these. Our efforts in the development

Analysis of tasks for dynamic man/machine load balancing in advanced helicopters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jorgensen, C.C.

1987-10-01

This report considers task allocation requirements imposed by advanced helicopter designs incorporating mixes of human pilots and intelligent machines. Specifically, it develops an analogy between load balancing using distributed non-homogeneous multiprocessors and human team functions. A taxonomy is presented which can be used to identify task combinations likely to cause overload for dynamic scheduling and process allocation mechanisms. Designer criteria are given for function decomposition, separation of control from data, and communication handling for dynamic tasks. Possible effects of n-p complete scheduling problems are noted and a class of combinatorial optimization methods are examined.

@Note: a workbench for biomedical text mining.

PubMed

Lourenço, Anália; Carreira, Rafael; Carneiro, Sónia; Maia, Paulo; Glez-Peña, Daniel; Fdez-Riverola, Florentino; Ferreira, Eugénio C; Rocha, Isabel; Rocha, Miguel

2009-08-01

Biomedical Text Mining (BioTM) is providing valuable approaches to the automated curation of scientific literature. However, most efforts have addressed the benchmarking of new algorithms rather than user operational needs. Bridging the gap between BioTM researchers and biologists' needs is crucial to solve real-world problems and promote further research. We present @Note, a platform for BioTM that aims at the effective translation of the advances between three distinct classes of users: biologists, text miners and software developers. Its main functional contributions are the ability to process abstracts and full-texts; an information retrieval module enabling PubMed search and journal crawling; a pre-processing module with PDF-to-text conversion, tokenisation and stopword removal; a semantic annotation schema; a lexicon-based annotator; a user-friendly annotation view that allows to correct annotations and a Text Mining Module supporting dataset preparation and algorithm evaluation. @Note improves the interoperability, modularity and flexibility when integrating in-home and open-source third-party components. Its component-based architecture allows the rapid development of new applications, emphasizing the principles of transparency and simplicity of use. Although it is still on-going, it has already allowed the development of applications that are currently being used.

The Common Fund Initiative and Its Implication for Advancing Exercise and Physical Activity Research in Child Health.

PubMed

Cooper, Dan M; Radom-Aizik, Shlomit

2015-08-01

NIH Director Francis Collins noted that the Common Fund initiative would lead to unprecedented insights into the mechanisms responsible for the health effects of physical activity. He noted: “Armed with this knowledge, researchers and clinicians may one day be able to define optimal physical activity recommendations for people at various stages of life, as well as develop precisely targeted regimens for individuals with particular health needs.” Given the ominous burden of physical inactivity-related diseases and conditions in otherwise healthy children, and the growing number of children who survive chronic diseases in whom we know little about what constitutes healthy exercise, it is essential that the community of child health researchers develop compelling strategies and proposals in response to the unique opportunity offered through the Common Fund mechanism.

Using advanced mobile devices in nursing practice--the views of nurses and nursing students.

PubMed

Johansson, Pauline; Petersson, Göran; Saveman, Britt-Inger; Nilsson, Gunilla

2014-09-01

Advanced mobile devices allow registered nurses and nursing students to keep up-to-date with expanding health-related knowledge but are rarely used in nursing in Sweden. This study aims at describing registered nurses' and nursing students' views regarding the use of advanced mobile devices in nursing practice. A cross-sectional study was completed in 2012; a total of 398 participants replied to a questionnaire, and descriptive statistics were applied. Results showed that the majority of the participants regarded an advanced mobile device to be useful, giving access to necessary information and also being useful in making notes, planning their work and saving time. Furthermore, the advanced mobile device was regarded to improve patient safety and the quality of care and to increase confidence. In order to continuously improve the safety and quality of health care, advanced mobile devices adjusted for nursing practice should be further developed, implemented and evaluated in research. © The Author(s) 2013.

Environmental Factors Influencing Blooms of a Neurotoxic Stigonematalan Cyanobacterium Responsible for Avian Vacuolar Myelinopathy

DTIC Science & Technology

2013-01-01

aquatic plants and subsequent ecological consequences. The authors of this technical note have linked avian vacuolar myelinopathy (AVM), a disease...additional cyanobacteria sequences to determine designations for probe development, to advance understanding of the species’ phylogeny , and to lay...groundwork for its formal description. Phylogeny data confirm that the species is in section V, order Stigonematales. Phylogeny also infers that the

Next-Generation Entrepreneurs Ready to Advance Breast Cancer Research Innovations | Poster

Cancer.gov

By Michele Newton and Thomas Stackhouse, Contributing Writers, and Rosemarie Truman, Guest Writer Editor’s note: In May 2014, the Breast Cancer Start-Up Challenge was named one of six finalists in the HHS Innovates Award Competition. This award celebrates innovations developed by employees of the U.S. Department of Health and Human Services (HHS) to support the mission of HHS.

On the Pursuit of Sound Science for the Betterment of the American Indian Community: Reply to Beals et al. (2009)

ERIC Educational Resources Information Center

Spillane, Nichea S.; Smith, Gregory T.

2009-01-01

The authors of this reply argue that ongoing criticism of existing theories, the development of alternative theories, and empirical theory tests offer the best chance for advancing American Indian research. The authors therefore note their appreciation for the comments of J. Beals et al. The authors nevertheless disagree with many of the specific…

21. Detail of steel ribs at south wall, T18; Note ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. Detail of steel ribs at south wall, T-18; Note composition of ribs--two steel channels welded together - Advance Base Depot Davisville, Building T-17, Ninth Street southeast of Davisville Road, Davisville, Washington County, RI

[The students' page. Notes about patient records and the production and reproduction of knowledge. Written and oral presentations].

PubMed

de Almeida, L B; dos Santos, E S; Alves, D de B

1995-01-01

This paper relates a description about nursing notes in pactients promptuaries in relation to the distribution/reproduction/production process of knowledge in nursing. It was developed on an Intensive Care Unity from a Hospital in the teaching/assistance Sanitary District Barra/Rio Vermelho (Salvador-Bahia). The basic premise is that the nursing personal work superficial and sporadic notes just related to patients. Distribution/ reproduction/production process, that happen in the nursing work process isn't considered by it devaluation or just because, for nursing agents, only information about technical procedures related to patient care, expresses the nursing knowledge and so, must be registered. In order to reach the objective, 30% of the promptuaries of patients discharge from the ICU were studied and the nursing team was interviewed, during the months-november, december 1994. The analysis indicates that the way how the nursing notes are been made, results in hard communication among agents of health area and contributes to disqualify the nursing assistance that is given to patients, besides to limit the advance of the distribution/reproduction/production of knowledge in nursing.

Underwater Advanced Time-Domain Electromagnetic System

DTIC Science & Technology

2017-03-03

SUPPLEMENTARY NOTES 14. ABSTRACT The overall objective of the project is to design , build and demonstrate an underwater advanced time -domain...Description The overall objective of the project is to design , build and demonstrate an underwater advanced time - domain electromagnetic (TEM) system...Electromagnetic System Design (July, 2015), and in the Underwater Advanced Time -Domain Electromagnetic System Evaluation Plan (October, 2016). A

Large space antennas: A systems analysis case history

NASA Technical Reports Server (NTRS)

Keafer, Lloyd S. (Compiler); Lovelace, U. M. (Compiler)

1987-01-01

The value of systems analysis and engineering is aptly demonstrated by the work on Large Space Antennas (LSA) by the NASA Langley Spacecraft Analysis Branch. This work was accomplished over the last half-decade by augmenting traditional system engineering, analysis, and design techniques with computer-aided engineering (CAE) techniques using the Langley-developed Interactive Design and Evaluation of Advanced Spacecraft (IDEAS) system. This report chronicles the research highlights and special systems analyses that focused the LSA work on deployable truss antennas. It notes developmental trends toward greater use of CAE techniques in their design and analysis. A look to the future envisions the application of improved systems analysis capabilities to advanced space systems such as an advanced space station or to lunar and Martian missions and human habitats.

Miniature surgical robots in the era of NOTES and LESS: dream or reality?

PubMed

Zygomalas, Apollon; Kehagias, Ioannis; Giokas, Konstantinos; Koutsouris, Dimitrios

2015-02-01

Laparoscopy is an established method for the treatment of numerous surgical conditions. Natural orifice transluminal endoscopic surgery (NOTES) is a novel surgical technique that uses the natural orifices of the human body as entrances to the abdominal cavity. An alternative concept of minimally invasive approach to the abdominal cavity is to insert all the laparoscopic instruments through ports using a single small incision on the abdominal wall. A suggested name for this technique is laparoendoscopic single-site surgery (LESS). Considering the technical difficulties in NOTES and LESS and the progress in informatics and robotics, the use of robots seems ideal. The aim of this study is to investigate if there is at present, a realistic possibility of using miniature robots in NOTES or LESS in daily clinical practice. An up-to-date review on in vivo surgical miniature robots is made. A Web-based research of the English literature up to March 2013 using PubMed, Scopus, and Google Scholar as search engines was performed. The development of in vivo miniature robots for use in NOTES or LESS is a reality with great advancements, potential advantages, and possible application in minimally invasive surgery in the future. However, true totally NOTES or LESS procedures on humans using miniature robots either solely or as assistance, remain a dream at present. © The Author(s) 2014.

A short note on economic development and socioeconomic inequality in female body weight.

PubMed

Deuchert, Eva; Cabus, Sofie; Tafreschi, Darjusch

2014-07-01

The origin of the obesity epidemic in developing countries is still poorly understood. It has been prominently argued that economic development provides a natural interpretation of the growth in obesity. This paper tests the main aggregated predictions of the theoretical framework to analyze obesity. Average body weight and health inequality should be associated with economic development. Both hypotheses are confirmed: we find higher average female body weight in economically more advanced countries. In relatively nondeveloped countries, obesity is a phenomenon of the socioeconomic elite. With economic development, obesity shifts toward individuals with lower socioeconomic status. Copyright © 2013 John Wiley & Sons, Ltd.

Enhanced In-Pile Instrumentation at the Advanced Test Reactor

NASA Astrophysics Data System (ADS)

Rempe, Joy L.; Knudson, Darrell L.; Daw, Joshua E.; Unruh, Troy; Chase, Benjamin M.; Palmer, Joe; Condie, Keith G.; Davis, Kurt L.

2012-08-01

Many of the sensors deployed at materials and test reactors cannot withstand the high flux/high temperature test conditions often requested by users at U.S. test reactors, such as the Advanced Test Reactor (ATR) at the Idaho National Laboratory. To address this issue, an instrumentation development effort was initiated as part of the ATR National Scientific User Facility in 2007 to support the development and deployment of enhanced in-pile sensors. This paper provides an update on this effort. Specifically, this paper identifies the types of sensors currently available to support in-pile irradiations and those sensors currently available to ATR users. Accomplishments from new sensor technology deployment efforts are highlighted by describing new temperature and thermal conductivity sensors now available to ATR users. Efforts to deploy enhanced in-pile sensors for detecting elongation and real-time flux detectors are also reported, and recently-initiated research to evaluate the viability of advanced technologies to provide enhanced accuracy for measuring key parameters during irradiation testing are noted.

7 CFR 1786.54 - Eligibility criteria.

Code of Federal Regulations, 2010 CFR

2010-01-01

... which is exempt from taxation under the Internal Revenue Code of 1986. (d) The borrower must have expended all funds advanced on account of the RUS Notes for the purposes for which such funds were advanced...

Assisting TMR Students.

ERIC Educational Resources Information Center

Turnquist, Antoinette E.

1988-01-01

High-school art teachers and student volunteers from advanced studio classes worked with trainable mentally retarded students on art projects such as abstract design paintings and note cards and potato-printed placemats. The impact of the experience on the handicapped students, the student aides, and the teachers is noted. (JDD)

Research requirements for development of improved helicopter rotor efficiency

NASA Technical Reports Server (NTRS)

Davis, S. J.

1976-01-01

The research requirements for developing an improved-efficiency rotor for a civil helicopter are documented. The various design parameters affecting the hover and cruise efficiency of a rotor are surveyed, and the parameters capable of producing the greatest potential improvement are identified. Research and development programs to achieve these improvements are defined, and estimated costs and schedules are presented. Interaction of the improved efficiency rotor with other technological goals for an advanced civil helicopter is noted, including its impact on engine noise, hover and cruise performance, one-engine-inoperative hover capability, and maintenance and reliability.

Mouse Models in Bone Marrow Transplantation and Adoptive Cellular Therapy

PubMed Central

Arber, Caroline; Brenner, Malcolm K.; Reddy, Pavan

2014-01-01

Mouse models of transplantation have been indispensable to the development of bone marrow transplantation (BMT). Their role in the generation of basic science knowledge is invaluable and is subject to discussion below. However, this article focuses on the direct role and relevance of mouse models towards the clinical development and advances in BMT and adoptive T-cell therapy for human diseases. The authors aim to present a thoughtful perspective on the pros and cons of mouse models while noting that despite imperfections these models are obligatory for the development of science-based medicine. PMID:24216170

Gerhard Herzberg: An Illustrious Life in Science

NASA Astrophysics Data System (ADS)

Stoicheff, Boris P.

2000-06-01

Herzberg always claimed it was his good fortune to start scientific work in the period between 1926 and 1928 which coincided with the high point in the development of molecular spectroscopy. And we are extremely lucky that he grasped this opportunity to advance the subject not only with his exemplary experiments on topics in physics, chemistry, and astrophysics, but with his classic treatment of molecular spectra and structures in four volumes, and his development of an outstanding laboratory which became the Mecca for young as well as established scientists the world-over. note

Feasibility and Acceptability of a Best Supportive Care Checklist among Clinicians.

PubMed

Boucher, Nathan A; Nicolla, Jonathan; Ogunseitan, Adeboye; Kessler, Elizabeth R; Ritchie, Christine S; Zafar, Yousuf Y

2018-04-23

Best supportive care (BSC) is often not standardized across sites, consistent with best evidence, or sufficiently described. We developed a consensus-based checklist to document BSC delivery, including symptom management, decision making, and care planning. We hypothesized that BSC can be feasibly documented with this checklist consistent with consolidated standards of reporting trials. To determine feasibility/acceptability of a BSC checklist among clinicians. To test feasibility of a BSC checklist in standard care, we enrolled a sample of clinicians treating patients with advanced cancer at four centers. Clinicians were asked to complete the checklist at eligible patient encounters. We surveyed enrollees regarding checklist use generating descriptive statistics and frequencies. We surveyed 15 clinicians and 9 advanced practice providers. Mean age was 41 (SD = 7.9). Mean years since fellowship for physicians was 7.2 (SD = 4.5). Represented specialties are medical oncology (n = 8), gynecologic oncology (n = 4), palliative care (n = 2), and other (n = 1). For "overall impact on your delivery of supportive/palliative care," 40% noted improved impact with using BSC. For "overall impact on your documentation of supportive/palliative care," 46% noted improvement. Impact on "frequency of comprehensive symptom assessment" was noted to be "increased" by 33% of providers. None noted decreased frequency or worsening impact on any measure with use of BSC. Regarding feasibility of integrating the checklist into workflow, 73% agreed/strongly agreed that checklists could be easily integrated, 73% saw value in integration, and 80% found it easy to use. Clinicians viewed the BSC checklist favorably illustrating proof of concept, minor workflow impact, and potential of benefit to patients.

10 CFR 2.1003 - Availability of material.

Code of Federal Regulations, 2011 CFR

2011-01-01

... months in advance of submitting its license application for a geologic repository, the NRC shall make... of privilege in § 2.1006, graphic-oriented documentary material that includes raw data, computer runs, computer programs and codes, field notes, laboratory notes, maps, diagrams and photographs, which have been...

10 CFR 2.1003 - Availability of material.

Code of Federal Regulations, 2012 CFR

2012-01-01

... months in advance of submitting its license application for a geologic repository, the NRC shall make... of privilege in § 2.1006, graphic-oriented documentary material that includes raw data, computer runs, computer programs and codes, field notes, laboratory notes, maps, diagrams and photographs, which have been...

Feasibility of Using Full Synthetic Low Viscosity Engine Oil at High Ambient Temperatures in U.S. Army Engines

DTIC Science & Technology

2011-06-01

Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Advancements in lubricant technology over the last two decades...in particular, the availability of high quality synthetic base oils, has set the stage for the development of a new fuel efficient, multifunctional...were conducted following two standard military testing cycles; the 210 h Tactical Wheeled Vehicle Cycle, and the 400 h NATO Hardware Endurance

Advances in space power research and technology at the National Aeronautics and Space Administration

NASA Technical Reports Server (NTRS)

Mullin, J. P.; Randolph, L. P.; Hudson, W. R.; Ambrus, J. H.

1981-01-01

Progress and plans in various areas of the NASA Space Power Program are discussed. Solar cell research is narrowed to GaAs, multibandgap, and thin Si cells for arrays in planar and concentrator configurations, with further work to increase cell efficiency, radiation hardness, develop flexible encapsulants, and reduce cost. Electrochemical research is concentrating on increasing energy and power density, cycle and wet stand life, reliability and cost reduction of batteries. Further development of the Ni-H2 battery and O2-H2 fuel cell to multihundred kW with a 5 year life and 30,000 cycles is noted. Basic research is ongoing for alkali metal anodes for high energy density secondary cells. Nuclear thermoelectric propulsion is being developed for outer planets exploration propulsion systems, using Si-Ge generators, and studies with rare earth chalcogenides and sulfides are mentioned. Power Systems Management seeks to harmonize increasing power supply levels with inner and outer spacecraft environments, circuits, demands, and automatic monitoring. Concomitant development of bipolar transistors, an infrared rectenna, spacecraft charging measurement, and larger heat pipe transport capacity are noted.

Syntactic/semantic techniques for feature description and character recognition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gonzalez, R.C.

1983-01-01

The Pattern Analysis Branch, Mapping, Charting and Geodesy (MC/G) Division, of the Naval Ocean Research and Development Activity (NORDA) has been involved over the past several years in the development of algorithms and techniques for computer recognition of free-form handprinted symbols as they appear on the Defense Mapping Agency (DMA) maps and charts. NORDA has made significant contributions to the automation of MC/G through advancing the state of the art in such information extraction techniques. In particular, new concepts in character (symbol) skeletonization, rugged feature measurements, and expert system-oriented decision logic have allowed the development of a very high performancemore » Handprinted Symbol Recognition (HSR) system for identifying depth soundings from naval smooth sheets (accuracies greater than 99.5%). The study reported in this technical note is part of NORDA's continuing research and development in pattern and shape analysis as it applies to Navy and DMA ocean/environment problems. The issue addressed in this technical note deals with emerging areas of syntactic and semantic techniques in pattern recognition as they might apply to the free-form symbol problem.« less

Airway Management in a Patient With Tracheal Disruption due to Penetrating Neck Trauma With Hollow Point Ammunition: A Case Report.

PubMed

Johnson, Angela M; Hill, James L; Zagorski, Dave J; McClain, Joseph M; Maronian, Nicole C

2017-11-27

Rapid sequence induction and intubation was performed for a patient in respiratory distress after a gunshot wound to the neck. Resistance was noted distal to vocal cords. With a bronchoscope unavailable, the endotracheal tube was advanced with a corkscrew maneuver. Subcutaneous emphysema had developed. The endotracheal tube was advanced into the right mainstem with adequate ventilation. Imaging illustrated tracheoesophageal injury. The patient was emergently explored. An intraluminal bullet was removed, lateral wall tracheal defect was repaired, and a tracheostomy was placed. The intubating provider should secure the airway by the method they are most comfortable, have high suspicion of airway injury, and prepare to manage airway disruption.

Airway Management in a Patient With Tracheal Disruption due to Penetrating Neck Trauma With Hollow Point Ammunition: A Case Report.

PubMed

Johnson, Angela M; Hill, James L; Zagorski, Dave J; McClain, Joseph M; Maronian, Nicole C

2018-05-01

Rapid sequence induction and intubation was performed for a patient in respiratory distress after a gunshot wound to the neck. Resistance was noted distal to vocal cords. With a bronchoscope unavailable, the endotracheal tube was advanced with a corkscrew maneuver. Subcutaneous emphysema had developed. The endotracheal tube was advanced into the right mainstem with adequate ventilation. Imaging illustrated tracheoesophageal injury. The patient was emergently explored. An intraluminal bullet was removed, lateral wall tracheal defect was repaired, and a tracheostomy was placed. The intubating provider should secure the airway by the method they are most comfortable, have high suspicion of airway injury, and prepare to manage airway disruption.

An eye for discovery

PubMed Central

Stahl, Andreas; Smith, Lois E.H.

2010-01-01

Vision research has often led to significant advances in our understanding of biology. There has also been particular success in translating basic research in the eye into breakthrough clinical therapies that mark important milestones for ophthalmology and also for medical research. Anti-VEGF therapy for age-related macular degeneration was named as one of the top ten science advancements of the year 2006. Only two years later, successful transfer of the RPE65 gene into retinal pigment epithelium of patients with Leber congenital amaurosis was noted as one of the most important clinical applications of gene therapy. The articles in this Review series outline current developments in vision research and highlight its continued importance in ophthalmology and medicine. PMID:20811156

Concept design and cluster control of advanced space connectable intelligent microsatellite

NASA Astrophysics Data System (ADS)

Wang, Xiaohui; Li, Shuang; She, Yuchen

2017-12-01

In this note, a new type of advanced space connectable intelligent microsatellite is presented to extend the range of potential application of microsatellite and improve the efficiency of cooperation. First, the overall concept of the micro satellite cluster is described, which is characterized by autonomously connecting with each other and being able to realize relative rotation through the external interfaces. Second, the multi-satellite autonomous assembly algorithm and control algorithm of the cluster motion are developed to make the cluster system combine into a variety of configurations in order to achieve different types of functionality. Finally, the design of the satellite cluster system is proposed, and the possible applications are discussed.

Open Access Integrated Therapeutic and Diagnostic Platforms for Personalized Cardiovascular Medicine

PubMed Central

Gladding, Patrick A.; Cave, Andrew; Zareian, Mehran; Smith, Kevin; Hussan, Jagir; Hunter, Peter; Erogbogbo, Folarin; Aguilar, Zoraida; Martin, David S.; Chan, Eugene; Homer, Margie L.; Shevade, Abhijit V.; Kassemi, Mohammad; Thomas, James D.; Schlegel, Todd T.

2013-01-01

It is undeniable that the increasing costs in healthcare are a concern. Although technological advancements have been made in healthcare systems, the return on investment made by governments and payers has been poor. The current model of care is unsustainable and is due for an upgrade. In developed nations, a law of diminishing returns has been noted in population health standards, whilst in the developing world, westernized chronic illnesses, such as diabetes and cardiovascular disease have become emerging problems. The reasons for these trends are complex, multifactorial and not easily reversed. Personalized medicine has the potential to have a significant impact on these issues, but for it to be truly successful, interdisciplinary mass collaboration is required. We propose here a vision for open-access advanced analytics for personalized cardiac diagnostics using imaging, electrocardiography and genomics. PMID:25562653

Democracy and Teacher Education: Setting Priorities

ERIC Educational Resources Information Center

Goodman, Jesse H.

2009-01-01

As John Dewey noted in his last book, each generation, in its turn, must assume responsibility as caretaker of democracy. He noted that one should never take democracy for granted. Everyone lives in an imperfect democracy, and teacher educators should play their part in protecting, nurturing, and advancing democratic ideals, rituals, values, and…

Thermal barrier coatings for aircraft engines: History and directions

NASA Technical Reports Server (NTRS)

Miller, R. A.

1995-01-01

Thin thermal barrier coatings for protecting aircraft turbine section airfoils are examined. The discussion focuses on those advances that led first to their use for component life extension and more recently as an integral part of airfoil design. It is noted that development has been driven by laboratory rig and furnace testing corroborated by engine testing and engine field experience. The technology has also been supported by performance modeling to demonstrate benefits and life modeling for mission analysis. Factors which have led to the selection of the current state-of-the-art plasma sprayed and physical vapor deposited zirconia-yttria/MCrAlY TBC's is emphasized in addition to observations fundamentally related to their behavior. Current directions in research into thermal barrier coatings and recent progress at NASA is also noted.

75 FR 42030 - Amendments to National Emission Standards for Hazardous Air Pollutants: Area Source Standards for...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-20

.... National Technology Transfer Advancement Act J. Executive Order 12898: Federal Actions to Address..., or use of energy. I. National Technology Transfer and Advancement Act Section 12(d) of the National Technology Transfer and Advancement Act of 1995 (``NTTAA''), Public Law 104-113 (15 U.S.C. 272 note) directs...

The Nine Planets Solar System Tour

Science.gov Websites

Astronomy news section which gives news, notes and general observations, we also have an interactive tour of ; Notes Astronomy picture of the day. For a full list of contents please see here. cna classes online Professional Astronomy research paper writing help can be found at AdvancedWriters.com. Solar system tour

Note Launchers: Promoting Active Reading of Mathematics Textbooks

ERIC Educational Resources Information Center

Helms, Josh W.; Helms, Kimberly Turner

2010-01-01

Note launchers, an instructor-designed reading guide, model how to select, decide, and focus upon what textbook material is important to learn. Reading guides are specially-designed study aids that can steer students through difficult parts of assigned readings (Bean, 1996) while encouraging advance preparation. As an example of a reading guide,…

NOTE: An innovative phantom for quantitative and qualitative investigation of advanced x-ray imaging technologies

NASA Astrophysics Data System (ADS)

Chiarot, C. B.; Siewerdsen, J. H.; Haycocks, T.; Moseley, D. J.; Jaffray, D. A.

2005-11-01

Development, characterization, and quality assurance of advanced x-ray imaging technologies require phantoms that are quantitative and well suited to such modalities. This note reports on the design, construction, and use of an innovative phantom developed for advanced imaging technologies (e.g., multi-detector CT and the numerous applications of flat-panel detectors in dual-energy imaging, tomosynthesis, and cone-beam CT) in diagnostic and image-guided procedures. The design addresses shortcomings of existing phantoms by incorporating criteria satisfied by no other single phantom: (1) inserts are fully 3D—spherically symmetric rather than cylindrical; (2) modules are quantitative, presenting objects of known size and contrast for quality assurance and image quality investigation; (3) features are incorporated in ideal and semi-realistic (anthropomorphic) contexts; and (4) the phantom allows devices to be inserted and manipulated in an accessible module (right lung). The phantom consists of five primary modules: (1) head, featuring contrast-detail spheres approximate to brain lesions; (2) left lung, featuring contrast-detail spheres approximate to lung modules; (3) right lung, an accessible hull in which devices may be placed and manipulated; (4) liver, featuring conrast-detail spheres approximate to metastases; and (5) abdomen/pelvis, featuring simulated kidneys, colon, rectum, bladder, and prostate. The phantom represents a two-fold evolution in design philosophy—from 2D (cylindrically symmetric) to fully 3D, and from exclusively qualitative or quantitative to a design accommodating quantitative study within an anatomical context. It has proven a valuable tool in investigations throughout our institution, including low-dose CT, dual-energy radiography, and cone-beam CT for image-guided radiation therapy and surgery.

Fake currency detection using image processing

NASA Astrophysics Data System (ADS)

Agasti, Tushar; Burand, Gajanan; Wade, Pratik; Chitra, P.

2017-11-01

The advancement of color printing technology has increased the rate of fake currency note printing and duplicating the notes on a very large scale. Few years back, the printing could be done in a print house, but now anyone can print a currency note with maximum accuracy using a simple laser printer. As a result the issue of fake notes instead of the genuine ones has been increased very largely. India has been unfortunately cursed with the problems like corruption and black money. And counterfeit of currency notes is also a big problem to it. This leads to design of a system that detects the fake currency note in a less time and in a more efficient manner. The proposed system gives an approach to verify the Indian currency notes. Verification of currency note is done by the concepts of image processing. This article describes extraction of various features of Indian currency notes. MATLAB software is used to extract the features of the note. The proposed system has got advantages like simplicity and high performance speed. The result will predict whether the currency note is fake or not.

Recent Advances in Archaeological Chemistry: A Summary of the Three Major Papers Presented as an Introduction to the Archeological Chemistry Symposium, Anaheim, California

NASA Astrophysics Data System (ADS)

Chen, Wen; Orna, Mary Virginia; O. S., U.

1996-06-01

Modern archaeology is fully supported by advances in science and technology. With the development of chemical and biochemical analyses, the task of the archaeological chemist has become more complex than ever over the past decade. In the symposium on archaeological chemistry held at the American Chemical Society National Meeting in Anaheim, California, from April 2-6, 1995, three noted scientists who have made seminal contributions in their respective fields presented an accompanying pedagogical symposium to provide introductory information on how modern chemistry and biochemistry have revolutionized modern archaeological studies at a molecular level. These three scientists and their presentations were: Stanley Ambrose, "Advances in Stable Isotope Analysis in Dietary Reconstruction"; Svante Pääbo, "Ancient DNA as a Means to Study the History of Humans and Extinct Creatures"; and Robert Hedges, "Radiocarbon Dating of Archaeological Bone by Accelerator Mass Spectrometry.

Evolving Concepts and Teaching Approaches In Tectonics and Sedimentation.

ERIC Educational Resources Information Center

Graham, Stephan Alan

1983-01-01

Discusses five recent advances in sedimentary tectonics, noting how they are incorporated into college curricula. Advances discussed include basin type, tectonic setting, facies analysis (in conjunction with basin type/setting), stratigraphic analysis of reflection seismic data, and quantitative analysis of subsidence histories of sedimentary…

Correction to: Apatinib: A Review in Advanced Gastric Cancer and Other Advanced Cancers.

PubMed

Scott, Lesley J

2018-05-04

An Online First version of this article was made available online at http://link.springer.com/journal/40265/onlineFirst/page/1 on 16 April 2018. Errors were subsequently identified in the article, and the following corrections should be noted.

Treatment of advanced canine anal sac adenocarcinoma with hypofractionated radiation therapy: 77 cases (1999-2013).

PubMed

McQuown, B; Keyerleber, M A; Rosen, K; McEntee, M C; Burgess, K E

2017-09-01

Currently no standard of care exists for advanced, inoperable or metastatic anal sac adenocarcinoma (ASAC). The objective of this retrospective study was to assess the role of hypofractionated radiation therapy (RT) in 77 dogs with measurable ASAC. A total of 38% of dogs experienced a partial response to RT. For dogs presenting with clinical signs related to the tumour, improvement or resolution of signs was noted in 63%. For dogs presenting with hypercalcemia of malignancy, resolution was noted in 31% with RT alone and an additional 46% with radiation, prednisone, and/or bisphosphonates. Median overall survival was 329 days (range: 252-448 days). Median progression free survival was 289 days (range: 224-469). There was no difference in survival based on radiation protocol, use of chemotherapy, previous surgery or advanced stage. Radiation toxicities were mild and infrequent. Hypofractionated RT is well tolerated and is applicable in the treatment of advanced primary, locoregional or metastatic ASAC. © 2016 John Wiley & Sons Ltd.

Implementation of a light-route TDMA communications satellite system for advanced business networks

NASA Astrophysics Data System (ADS)

Hanson, B.; Smalley, A.; Zuliani, M.

The application of Light Route TDMA systems to various business communication requirements is discussed. It is noted that full development of this technology for use in advanced business networks will be guided by considerations of flexibility, reliability, security, and cost. The implementation of the TDMA system for demonstrating these advantages to a wide range of public and private organizations is described in detail. Among the advantages offered by this system are point-to-point and point-to-multipoint (broadcast) capability; the ability to vary the mix and quantity of services between destinations in a fully connected mesh network on an almost instantaneous basis through software control; and enhanced reliability with centralized monitor, alarm and control functions by virtue of an overhead channel.

'Round-table' ethical debate: is a suicide note an authoritative 'living will'?

PubMed

Chalfin, D B; Crippen, D; Franklin, C; Kelly, D F; Kilcullen, J K; Streat, S; Truog, R D; Whetstine, L M

2001-01-01

Living wills are often considered by physicians who are faced with a dying patient. Although popular with the general public, they remain problems of authenticity and authority. It is difficult for the examining physician to know whether the patient understood the terms of the advance directive when they signed it, and whether they still consider it authoritative at the time that it is produced. Also, there is little consensus on what spectrum of instruments constitutes a binding advance directive in real life. Does a 'suicide note' constitute an authentic and authoritative 'living will'? Our panel of authorities considers this problem in a round-table discussion.

Construction of dynamic stochastic simulation models using knowledge-based techniques

NASA Technical Reports Server (NTRS)

Williams, M. Douglas; Shiva, Sajjan G.

1990-01-01

Over the past three decades, computer-based simulation models have proven themselves to be cost-effective alternatives to the more structured deterministic methods of systems analysis. During this time, many techniques, tools and languages for constructing computer-based simulation models have been developed. More recently, advances in knowledge-based system technology have led many researchers to note the similarities between knowledge-based programming and simulation technologies and to investigate the potential application of knowledge-based programming techniques to simulation modeling. The integration of conventional simulation techniques with knowledge-based programming techniques is discussed to provide a development environment for constructing knowledge-based simulation models. A comparison of the techniques used in the construction of dynamic stochastic simulation models and those used in the construction of knowledge-based systems provides the requirements for the environment. This leads to the design and implementation of a knowledge-based simulation development environment. These techniques were used in the construction of several knowledge-based simulation models including the Advanced Launch System Model (ALSYM).

Drive-train dynamics technology - State-of-the-art and design of a test facility for advanced development

NASA Technical Reports Server (NTRS)

Badgley, R. H.; Fleming, D. P.; Smalley, A. J.

1975-01-01

A program for the development and verification of drive-train dynamic technology is described along with its basis and the results expected from it. A central feature of this program is a drive-train test facility designed for the testing and development of advanced drive-train components, including shaft systems, dampers, and couplings. Previous efforts in designing flexible dynamic drive-train systems are reviewed, and the present state of the art is briefly summarized. The design of the test facility is discussed with major attention given to the formulation of the test-rig concept, dynamic scaling of model shafts, and the specification of design parameters. Specific efforts envisioned for the test facility are briefly noted, including evaluations of supercritical test shafts, stability thresholds for various sources and types of instabilities that can exist in shaft systems, effects of structural flexibility on the dynamic performance of dampers, and methods for vibration control in two-level and three-level flexible shaft systems.

Knowledge-based systems for power management

NASA Technical Reports Server (NTRS)

Lollar, L. F.

1992-01-01

NASA-Marshall's Electrical Power Branch has undertaken the development of expert systems in support of further advancements in electrical power system automation. Attention is given to the features (1) of the Fault Recovery and Management Expert System, (2) a resource scheduler or Master of Automated Expert Scheduling Through Resource Orchestration, and (3) an adaptive load-priority manager, or Load Priority List Management System. The characteristics of an advisory battery manager for the Hubble Space Telescope, designated the 'nickel-hydrogen expert system', are also noted.

Development of Advanced Technologies for Complete Genomic and Proteomic Characterization of Quantized Human Tumor Cells

DTIC Science & Technology

2014-07-01

13. SUPPLEMENTARY NOTES 14. ABSTRACT With the establishment of Glioblastoma ( GBM ) cell lines from GBM patient’s tumor samples and quantized cell...populations of each of the parental GBM cell lines, we have completed most of our major aims of this project. We will continue in our efforts in the...signatures. Whole genome sequencing from two families of GBM patients are now well established and from the basis of the molecular characterization of

Part 10: Pediatric Basic and Advanced Life Support 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

PubMed Central

Kleinman, Monica E.; de Caen, Allan R.; Chameides, Leon; Atkins, Dianne L.; Berg, Robert A.; Berg, Marc D.; Bhanji, Farhan; Biarent, Dominique; Bingham, Robert; Coovadia, Ashraf H.; Hazinski, Mary Fran; Hickey, Robert W.; Nadkarni, Vinay M.; Reis, Amelia G.; Rodriguez-Nunez, Antonio; Tibballs, James; Zaritsky, Arno L.; Zideman, David

2013-01-01

Note From the Writing Group: Throughout this article, the reader will notice combinations of superscripted letters and numbers (eg, “Family Presence During ResuscitationPeds-003”). These callouts are hyperlinked to evidence-based worksheets, which were used in the development of this article. An appendix of worksheets, applicable to this article, is located at the end of the text. The worksheets are available in PDF format and are open access. PMID:20956258

[Research advances in association between childhood obesity and gut microbiota].

PubMed

Gao, Xiao-Lin; Wan, Chao-Min

2017-03-01

In recent years, more and more studies have noted the close association between gut microbiota and the development and progression of obesity. Gut microbiota may act on obesity by increasing energy intake, affecting the secretion of intestinal hormones, inducing chronic systemic inflammation, and producing insulin resistance. This article reviews the association between childhood obesity and gut microbiota, as well as possible mechanisms, in an attempt to provide a reference for the etiology, prevention and treatment of childhood obesity.

Optical FIBer Intrusion LOCation Sensor System (FIBLOC) for Surface and Subsurface Perimeter Protection. Phase 2

DTIC Science & Technology

1994-01-01

second gate indicating that the intruder is a runner or a fast truck. FILTER ASCPNFIER ONESHOT AND LOGIC BUS B note: t 0 0 7 the Q--. BISTABLE MV...Minutes of the PINTSITIWG Meeting. Test Integration Working Group, Fort Belvoir Research . Development and Engineering Center, Ft. Belvoir. VA, 22 April...MP-CD ADVANCED RESEARCH PROJECT AGENCY ATTN: ATZN-MP-DE ATTN: EAO ATTN: ATZN-MP-TB ATTN: STO N DOHERTY ATTN: ATZN-MP-TS DEFENSE INTELLIGENCE AGENCY U

Introduction to Part I

NASA Astrophysics Data System (ADS)

Strocchi, Franco

These notes essentially reproduce lectures given at the International School for Advanced Studies (Trieste) and at the Scuola Normale Superiore (Pisa) on various occasions. The scope of the short series of lectures, typically a fraction of a one-semester course, was to explain on general grounds, also to mathematicians, the phenomenon of Spontaneous Symmetry Breaking (SSB), a mechanism which seems at the basis of most of the recent developments in theoretical physics (from Statistical Mechanics to Many-Body theory and to Elementary Particle theory).

An outlook for cargo aircraft of the future. [assessment of the future of air cargo by analyzing statistics and trends

NASA Technical Reports Server (NTRS)

Nicks, O. W.; Whitehead, A. H., Jr.; Alford, W. J., Jr.

1975-01-01

An assessment is provided of the future of air cargo by analyzing air cargo statistics and trends, by noting air cargo system problems and inefficiencies, by analyzing characteristics of air-eligible commodities, and by showing the promise of new technology for future cargo aircraft with significant improvements in costs and efficiency. NASA's proposed program is reviewed which would sponsor the research needed to provide for development of advanced designs by 1985.

Compendium of Lecture Notes for Training Class III Meteorological Personnel.

ERIC Educational Resources Information Center

Retallack, B. J.

This compendium of lecture notes provides a course of study for persons who may be involved in a variety of specialized meteorological tasks. The course is considered to be advanced and assumes students have had introductory experiences in meteorology and earth science (covered in a similar compendium). The material is presented in seven units…

E-suicide note: A newer trend and its medico-legal implications in India.

PubMed

Behera, C; Karthik, Krishna; Dogra, Td; Lalwani, S; Millo, T; Singh, Sr

2014-06-01

Rapid advancements of information and communication technology in the form of electronic mails, mobile phones, social networking sites, etc have an increasing impact on people's day to day life. It has been observed that these readily available applications are used frequently to express suicidal intentions. There are many studies on conventional handwritten suicide notes but suicide note in electronic format is an emerging issue and an under-researched phenomena. The authors have termed it as "E-suicide note" and discuss its medico-legal implications in India with examples from their observations. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Magnet Architectures and Active Radiation Shielding Study - SR2S Workshop

NASA Technical Reports Server (NTRS)

Westover, Shane; Meinke, Rainer; Burger, William; Ilin, Andrew; Nerolich, Shaun; Washburn, Scott

2014-01-01

Analyze new coil configurations with maturing superconductor technology -Develop vehicle-level concept solutions and identify engineering challenges and risks -Shielding performance analysis Recent advances in superconducting magnet technology and manufacturing have opened the door for re-evaluating active shielding solutions as an alternative to mass prohibitive passive shielding.Publications on static magnetic field environments and its bio-effects were reviewed. Short-term exposure information is available suggesting long term exposure may be okay. Further research likely needed. center dotMagnetic field safety requirements exist for controlled work environments. The following effects have been noted with little noted adverse effects -Magnetohydrodynamic (MHD) effects on ionized fluids (e.g. blood) creating an aortic voltage change -MHD interaction elevates blood pressure (BP) center dot5 Tesla equates to 5% BP elevation -Prosthetic devises and pacemakers are an issue (access limit of 5 gauss).

Teacher Leaders: Advancing Mathematics Learning

ERIC Educational Resources Information Center

Kinzer, Cathy J.; Rincón, Mari; Ward, Jana; Rincón, Ricardo; Gomez, Lesli

2014-01-01

Four elementary school instructors offer insights into their classrooms, their unique professional roles, and their leadership approaches as they reflect on their journey to advance teacher and student mathematics learning. They note a "teacher leader" serves as an example to other educators and strives to impact student learning;…

76 FR 77458 - Amendment to Agency Rules of Practice

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-13

... Advancement Act (Technical Standards) The National Technology Transfer and Advancement Act (15 U.S.C. 272 note... forwarders it determines are reincarnations of other entities with a history of failing to comply with..., if submitted on behalf of an association, business, labor union, etc.). You may review the Department...

Democracy in America: Starting at the Source.

ERIC Educational Resources Information Center

Serow, Ann G.

1986-01-01

This article notes that the May 1987 release of the College Board's advanced placement exam in American government gives high school social studies departments good reason to reassess and improve their advanced placement programs. It shows how Alexis de Toqueville's classic 1935 work, "Democracy in America," may be used as a central…

Equity, Status and Freedom: A Note on Higher Education

ERIC Educational Resources Information Center

Marginson, Simon

2011-01-01

Strategies to enhance socio-economic equity in higher education embody one or both of two objectives. The first strategy is to advance "fairness" by changing the composition of participation, bringing higher education into line with the ideal model of a socially representative system. The second strategy advances "inclusion" by…

Data Analysis and Modeling to Support NOWCAST and Forecast Activities at the Fallon Naval Air Station

DTIC Science & Technology

2008-09-30

Remagnino, A. Nefian, G. Meenakshisundaram, V. Pascucci, J. Zara , J. Molineros, H. Thiesel, and T. Malzbender, Eds., 2006: Advances in Visual...Nefian, G. Meenakshisundaram, V. Pascucci, J. Zara , J. Molineros, H. Thiesel, and T. Malzbender, Eds., 2006: Advances in Visual Computing. Lecture Notes

Using Technology to Support Students' Mastery of Academic Studies. Best Practices Newsletter

ERIC Educational Resources Information Center

Southern Regional Education Board (SREB), 2015

2015-01-01

For decades, classroom instruction was dominated by lectures, textbooks and note-taking. And for decades, students have often been bored and unengaged. They took notes and did what they had to do to memorize lessons just long enough to pass an exam. But short-term memorization does not help much in preparing students for college, advanced training…

Development of tactile sensory circuits in the CNS.

PubMed

Iwasato, Takuji; Erzurumlu, Reha S

2018-06-13

Molecular identification of neuronal types and genetic and imaging approaches to characterize their properties reveal morphological, physiological and dynamic aspects of sensory circuit development. Here we focus on the mouse tactile sensory circuitry, with particular emphasis on the main trigeminal pathway that connects the whiskers, the major tactile organ in rodents, to the neocortex. At each level of this pathway, neurogenesis, axonal elongation, pathfinding, target recognition and circuit reorganization including dendritic refinement of cortical layer 4 neurons occur contemporaneously and a multitude of molecular signals are used in differing combinations. We highlight recent advances in development of tactile circuitry and note gaps in our understanding. Copyright © 2018 Elsevier Ltd. All rights reserved.

Advanced Computational Methods for Optimization of Non-Periodic Inspection Intervals for Aging Infrastructure

DTIC Science & Technology

2017-01-05

AFRL-AFOSR-JP-TR-2017-0002 Advanced Computational Methods for Optimization of Non-Periodic Inspection Intervals for Aging Infrastructure Manabu...Computational Methods for Optimization of Non-Periodic Inspection Intervals for Aging Infrastructure 5a.  CONTRACT NUMBER 5b.  GRANT NUMBER FA2386...UNLIMITED: PB Public Release 13. SUPPLEMENTARY NOTES 14. ABSTRACT This report for the project titled ’Advanced Computational Methods for Optimization of

An Intervention to Control Vasomotor Symptoms for Advanced PC Patients on Hormone Therapy

DTIC Science & Technology

2014-08-01

Symptoms for Advanced PC Patients on Hormone Therapy PRINCIPAL INVESTIGATOR: Michael A. Diefenbach, Ph.D. CONTRACTING ORGANIZATION...Control Vasomotor Symptoms for Advanced PC Patients on Hormone Therapy 5a. CONTRACT NUMBER 5b. GRANT NUMBER W81XWH-11-1-0604 5c...NOTES 14. ABSTRACT Vasomotor Symptom (Hot Flashes) is a common side-effect of hormone therapy for prostate cancer survivors who experience a rising

NASA Space Technology Roadmaps and Priorities: Restoring NASA's Technological Edge and Paving the Way for a New Era in Space

NASA Technical Reports Server (NTRS)

2012-01-01

Success in executing future NASA space missions will depend on advanced technology developments that should already be underway. It has been years since NASA has had a vigorous, broad-based program in advanced space technology development, and NASA's technology base is largely depleted. As noted in a recent National Research Council report on the U.S. civil space program: Future U.S. leadership in space requires a foundation of sustained technology advances that can enable the development of more capable, reliable, and lower-cost spacecraft and launch vehicles to achieve space program goals. A strong advanced technology development foundation is needed also to enhance technology readiness of new missions, mitigate their technological risks, improve the quality of cost estimates, and thereby contribute to better overall mission cost management. Yet financial support for this technology base has eroded over the years. The United States is now living on the innovation funded in the past and has an obligation to replenish this foundational element. NASA has developed a draft set of technology roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist. The NRC appointed the Steering Committee for NASA Technology Roadmaps and six panels to evaluate the draft roadmaps, recommend improvements, and prioritize the technologies within each and among all of the technology areas as NASA finalizes the roadmaps. The steering committee is encouraged by the initiative NASA has taken through the Office of the Chief Technologist (OCT) to develop technology roadmaps and to seek input from the aerospace technical community with this study.

How Can We Mobilize Action to Realize UHC in Asia?

PubMed

Akaza, Hideyuki; Kawahara, Norie; Fukuda, Takashi; Horie, Shigeo; Thabrany, Hasbullah; Nozaki, Shinjiro

2017-11-26

The 2016 World Cancer Congress, organised by UICC, was held in Paris in November 2016, under the theme “Mobilizing action – Inspiring Change.” As part of Track 4 presentations on the theme of “Strengthening cancer control: optimizing outcomes of health systems,” UICC-Asian Regional Office (UICC-ARO) held a symposium to discuss the issue of mobilizing action to realize UHC in Asia. Introducing the symposium, Hideyuki Akaza noted that universal health coverage (UHC) is included in the Sustainable Development Goals and one of the key issues for achieving UHC will be how to balance patient needs with the economic burden of cancer. Speakers from Japan and Indonesia addressed various issues, including the current status and challenges for medical economic evaluation in Asia, the importance of resource stratification, prospects for precision medicine, and the outlook for cancer control and UHC in developing and emerging countries in Asia. Key issues raised included how to respond to the rising costs of treating cancer as new and increasingly expensive drugs come to the market. Speakers and participants noted that health technology assessment programs are being developed around Asia in order to evaluate the cost-effectiveness of drugs in the face of budgetary constraints within increasingly pressurized national health systems. The importance of screening and early detection was also noted as effective means that have the potential to reduce reliance on expensive drugs for advanced cancers. The symposium was chaired jointly by Hideyuki Akaza and Shinjiro Nozaki (WHO Kobe Centre). Creative Commons Attribution License

Optimizing the interaction of children with information and communication technologies.

PubMed

Straker, L; Pollock, C

2005-04-15

This paper outlines the major changes in the lives of children in industrially advanced countries associated with the increased interaction with information and communication technologies. The potential opportunities and threats to the cognitive, social, physical and visual development of children are reviewed to emphasize the importance of optimizing the interaction. The change in children's use of technology also poses opportunities and threats for ergonomics that should be noted if the profession is to continue being relevant and useful into this century. The paper ends with a pathway to the development and implementation of guidelines about child information and communication technology use for different groups of guideline users.

Solar power satellite

NASA Technical Reports Server (NTRS)

Davis, H. P.

1978-01-01

The solar power satellite (SPS) concept, under evaluation by NASA since 1974, is discussed. A typical system providing a total of 10,000 MW of electrical power to the ground receiving stations is considered. Energy conversion systems, including the photovoltaic device category using single-crystal silicon cells, are taken into account, as are the 2.45-GHz microwave power-transmission link and the ground receiver (or rectenna). Concepts involving space construction of the satellite's large structures (5 x 25 km) are described, noting that a process similar to the familiar roll-forming of light sheet metal parts has been adapted to the space environment. Transportation vehicles are discussed, including the Space Shuttle planned to reach 60 flights per year by the mid 1980's. Electrical power forecasts and advanced systems cost projections are analyzed, together with a description of costs estimates. The indirect economics of energy research and development, and the present NASA/DOE SPS program are noted.

Creating an advance-care-planning decision aid for high-risk surgery: a qualitative study

PubMed Central

2014-01-01

Background High-risk surgery patients may lose decision-making capacity as a result of surgical complications. Advance care planning prior to surgery may be beneficial, but remains controversial and is hindered by a lack of appropriate decision aids. This study sought to examine stakeholders’ views on the appropriateness of using decision aids, in general, to support advance care planning among high-risk surgery populations and the design of such a decision aid. Methods Key informants were recruited through purposive and snowball sampling. Semi-structured interviews were conducted by phone until data collected reached theoretical saturation. Key informants were asked to discuss their thoughts about advance care planning and interventions to support advance care planning, particularly for this population. Researchers took de-identified notes that were analyzed for emerging concordant, discordant, and recurrent themes using interpretative phenomenological analysis. Results Key informants described the importance of initiating advance care planning preoperatively, despite potential challenges present in surgical settings. In general, decision aids were viewed as an appropriate approach to support advance care planning for this population. A recipe emerged from the data that outlines tools, ingredients, and tips for success that are needed to design an advance care planning decision aid for high-risk surgical settings. Conclusions Stakeholders supported incorporating advance care planning in high-risk surgical settings and endorsed the appropriateness of using decision aids to do so. Findings will inform the next stages of developing the first advance care planning decision aid for high-risk surgery patients. PMID:25067908

Creating an advance-care-planning decision aid for high-risk surgery: a qualitative study.

PubMed

Schuster, Anne Lr; Aslakson, Rebecca A; Bridges, John Fp

2014-01-01

High-risk surgery patients may lose decision-making capacity as a result of surgical complications. Advance care planning prior to surgery may be beneficial, but remains controversial and is hindered by a lack of appropriate decision aids. This study sought to examine stakeholders' views on the appropriateness of using decision aids, in general, to support advance care planning among high-risk surgery populations and the design of such a decision aid. Key informants were recruited through purposive and snowball sampling. Semi-structured interviews were conducted by phone until data collected reached theoretical saturation. Key informants were asked to discuss their thoughts about advance care planning and interventions to support advance care planning, particularly for this population. Researchers took de-identified notes that were analyzed for emerging concordant, discordant, and recurrent themes using interpretative phenomenological analysis. Key informants described the importance of initiating advance care planning preoperatively, despite potential challenges present in surgical settings. In general, decision aids were viewed as an appropriate approach to support advance care planning for this population. A recipe emerged from the data that outlines tools, ingredients, and tips for success that are needed to design an advance care planning decision aid for high-risk surgical settings. Stakeholders supported incorporating advance care planning in high-risk surgical settings and endorsed the appropriateness of using decision aids to do so. Findings will inform the next stages of developing the first advance care planning decision aid for high-risk surgery patients.

Informal Content and Student Note-Taking in Advanced Mathematics Classes

ERIC Educational Resources Information Center

Fukawa-Connelly, Timothy; Weber, Keith; Mejía-Ramos, Juan Pablo

2017-01-01

This study investigates 3 hypotheses about proof-based mathematics instruction: (a) that lectures include informal content (ways of thinking and reasoning about advanced mathematics that are not captured by formal symbolic statements), (b) that informal content is usually presented orally but not written on the board, and (c) that students do not…

Rewriting in Advanced Composition.

ERIC Educational Resources Information Center

Stone, William B.

A college English instructor made an informal comparison of rewriting habits of students in a freshman composition course and two advanced composition courses. Notes kept on student rewriting focused on this central question: given peer and instructor response to their papers and a choice as to what and how to rewrite, what will students decide to…

12 CFR 1024.17 - Escrow accounts.

Code of Federal Regulations, 2014 CFR

2014-01-01

... Statement required in § 1024.17(g). (b) Definitions. As used in this section: Aggregate (or) composite... amount of a negative balance in an escrow account. As noted in § 1024.17(f), if a servicer advances funds... advances funds in paying a disbursement, which is not the result of a borrower's payment default under the...

7 CFR 1980.373 - Special loan servicing.

Code of Federal Regulations, 2012 CFR

2012-01-01

... modification, then the Lender may consider a mortgage recovery advance in addition to the extended-term loan... recovery advance is not repaid based on the terms outlined in the promissory note and mortgage or deed-of... maximum allowable interest rate and extend the term of the loan up to 40 years from the date of loan...

7 CFR 1980.373 - Special loan servicing.

Code of Federal Regulations, 2014 CFR

2014-01-01

... modification, then the Lender may consider a mortgage recovery advance in addition to the extended-term loan... recovery advance is not repaid based on the terms outlined in the promissory note and mortgage or deed-of... maximum allowable interest rate and extend the term of the loan up to 40 years from the date of loan...

7 CFR 1980.373 - Special loan servicing.

Code of Federal Regulations, 2011 CFR

2011-01-01

... modification, then the Lender may consider a mortgage recovery advance in addition to the extended-term loan... recovery advance is not repaid based on the terms outlined in the promissory note and mortgage or deed-of... maximum allowable interest rate and extend the term of the loan up to 40 years from the date of loan...

7 CFR 1980.373 - Special loan servicing.

Code of Federal Regulations, 2013 CFR

2013-01-01

... modification, then the Lender may consider a mortgage recovery advance in addition to the extended-term loan... recovery advance is not repaid based on the terms outlined in the promissory note and mortgage or deed-of... maximum allowable interest rate and extend the term of the loan up to 40 years from the date of loan...

EDT mode for JED -- An advanced Unix text editor

NASA Astrophysics Data System (ADS)

McIlwrath, B. K.; Page, C. G.

This note describes Starlink extended EDT emulation for the JED editor. It provides a Unix text editor which can utilise the advanced facilities of DEC VTn00, xterm and similar terminals. JED in this mode provides a reasonably good emulation of the VAX/VMS editor EDT in addition to many extra facilities.

Cellulosic butanol production from agricultural biomass and residues: Recent advances in technology

USDA-ARS?s Scientific Manuscript database

This chapter details the recent advances made on bioconversion of lignocellulosic biomass to butanol, a superior biofuel that can be used in internal combustion engines or transportation industry. It should be noted that butanol producing cultures cannot tolerate or produce more than 20-30 g/L of ac...

Notes on Advanced Engineering Education

ERIC Educational Resources Information Center

Klimenko, A. Y.

2017-01-01

This article reviews history, analyses principles and presents a modern interpretation of advanced engineering education (AEE). AEE originated in France, was adapted in Germany and reached its zenith in the second half of the twentieth century as part of technological efforts induced by the space race. AEE is an enhanced form of education aimed at…

Electronic warfare antenna systems - Past and present

NASA Astrophysics Data System (ADS)

Yaw, D.

1981-09-01

In discussing fixed beam arrays, it is noted that an array may be used to create simultaneous fixed beams or to form asymmetric beams of a desired shape. Attention is also given to arrays and beam control, noting that for some electronic warfare applications combinations of broad and narrow beam antenna response are needed. Other topics include ECM jamming antenna techniques and advanced array systems.

Review of Pure Endoscopic Full-Thickness Resection of the Upper Gastrointestinal Tract

PubMed Central

Mori, Hirohito; Kobara, Hideki; Nishiyama, Noriko; Fujihara, Shintaro; Masaki, Tsutomu

2015-01-01

Natural-orifice transluminal endoscopic surgery (NOTES) using flexible endoscopy has attracted attention as a minimally invasive surgical method that does not cause an operative wound on the body surface. However, minimizing the number of devices involved in endoscopic, compared to laparoscopic, surgeries has remained a challenge, causing endoscopic surgeries to gradually be phased out of use. If a flexible endoscopic full-thickness suturing device and a counter-traction device were developed to expand the surgical field for gastrointestinal-tract collapse, then endoscopic full-thickness resection using NOTES, which is seen as an extension of endoscopic submucosal dissection for full-thickness excision of tumors involving the gastrointestinal-tract wall, might become an extremely minimally invasive surgical method that could be used to resect only full-thickness lesions approached by the shortest distance via the mouth. It is expected that gastroenterological endoscopists will use this surgery if device development is advanced. This extremely minimally invasive surgery would have an immeasurable impact with regard to mitigating the burden on patients and reducing healthcare costs. Development of a new surgical method using a multipurpose flexible endoscope is therefore considered a socially urgent issue. PMID:26343069

Next-Generation Entrepreneurs Ready to Advance Breast Cancer Research Innovations | Poster

Cancer.gov

By Michele Newton and Thomas Stackhouse, Contributing Writers, and Rosemarie Truman, Guest Writer Editor’s note: In May 2014, the Breast Cancer Start-Up Challenge was named one of six finalists in the HHS Innovates Award Competition. This award celebrates innovations developed by employees of the U.S. Department of Health and Human Services (HHS) to support the mission of HHS. In the final phase of the competition, the public will be invited to help select “The People’s Choice” winner; public voting takes place May 29 through June 6, 2014.

The Development of an Advanced Anti-Icing/Deicing Capability for U.S. Army Helicopters. Volume 1. Design Criteria and Technology Considerations

DTIC Science & Technology

1975-11-01

EFFECT OF ICING CONDITIONS ON THE ZPG-2 AIRSHIP , NACA Technical Note 4220, Washington, D. C., April 1958. 28A * jb 7 -- ALBANYI I I,- 99 { T: FLINT...replicator (Figure 45) which featurek 35-mm slide frames coated with gelatine . Momentary exposure past an open slot leaves permanent footprints (cavi- ties...in the gelatine substance (Figure 46). In order to capture a true sample, the collection efficienuj of the collector (i.e., the fraction of 139 II r

Advancing a Program of Research within a Nursing Faculty Role

PubMed Central

Nolan, Marie T.; Wenzel, Jennifer; Han, Hae-Ra.; Allen, Jerilyn K.; Paez, Kathryn A.; Mock, Victoria

2008-01-01

Doctoral students and new faculty members often seek advice from more senior faculty on how to advance their program of research. Students may ask whether they should choose the manuscript option for their dissertation or whether they should seek a postdoctoral fellowship. New faculty members wonder whether they should pursue a career development (K) award and whether they need a mentor as they strive to advance their research while carrying out teaching, service, and practice responsibilities. In this paper, we describe literature on the impact of selected aspects of pre and postdoctoral training and faculty strategies on scholarly productivity in the faculty role. We also combine our experiences at a school of nursing within a research-intensive university to suggest strategies for success. Noting the scarcity of research that evaluates the effect of these strategies we are actively engaged in collecting data on their relationship to the scholarly productivity of students and faculty members within our own institution. PMID:19022210

Classical Electrodynamics: Lecture notes

NASA Astrophysics Data System (ADS)

Likharev, Konstantin K.

2018-06-01

Essential Advanced Physics is a series comprising four parts: Classical Mechanics, Classical Electrodynamics, Quantum Mechanics and Statistical Mechanics. Each part consists of two volumes, Lecture notes and Problems with solutions, further supplemented by an additional collection of test problems and solutions available to qualifying university instructors. This volume, Classical Electrodynamics: Lecture notes is intended to be the basis for a two-semester graduate-level course on electricity and magnetism, including not only the interaction and dynamics charged point particles, but also properties of dielectric, conducting, and magnetic media. The course also covers special relativity, including its kinematics and particle-dynamics aspects, and electromagnetic radiation by relativistic particles.

Advances in Tissue Engineering Techniques for Articular Cartilage Repair

PubMed Central

Haleem, AM; Chu, CR

2010-01-01

The limited repair potential of human articular cartilage contributes to development of debilitating osteoarthritis and remains a great clinical challenge. This has led to evolution of cartilage treatment strategies from palliative to either reconstructive or reparative methods in an attempt to delay or “bridge the gap” to joint replacement. Further development of tissue engineering-based cartilage repair methods have been pursued to provide a more functional biological tissue. Currently, tissue engineering of articular cartilage has three cornerstones; a cell population capable of proliferation and differentiation into mature chondrocytes, a scaffold that can host these cells, provide a suitable environment for cellular functioning and serve as a sustained-release delivery vehicle of chondrogenic growth factors and thirdly, signaling molecules and growth factors that stimulate the cellular response and the production of a hyaline extracellular matrix (ECM). The aim of this review is to summarize advances in each of these three fields of tissue engineering with specific relevance to surgical techniques and technical notes. PMID:29430164

Application of Advanced Wide Area Early Warning Systems with Adaptive Protection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blumstein, Carl; Cibulka, Lloyd; Thorp, James

2014-09-30

Recent blackouts of power systems in North America and throughout the world have shown how critical a reliable power system is to modern societies, and the enormous economic and societal damage a blackout can cause. It has been noted that unanticipated operation of protection systems can contribute to cascading phenomena and, ultimately, blackouts. This project developed and field-tested two methods of Adaptive Protection systems utilizing synchrophasor data. One method detects conditions of system stress that can lead to unintended relay operation, and initiates a supervisory signal to modify relay response in real time to avoid false trips. The second methodmore » detects the possibility of false trips of impedance relays as stable system swings “encroach” on the relays’ impedance zones, and produces an early warning so that relay engineers can re-evaluate relay settings. In addition, real-time synchrophasor data produced by this project was used to develop advanced visualization techniques for display of synchrophasor data to utility operators and engineers.« less

The scientific legacy of Little Hans and Little Albert: future directions for research on specific phobias in youth.

PubMed

Ollendick, Thomas H; Muris, Peter

2015-01-01

We review issues associated with the phenomenology, etiology, assessment, and treatment of specific phobias in children and adolescents and provide suggestions for future research and clinical practice. In doing so, we highlight the early case studies of Little Hans and Little Albert and the advances that have been made following the publication of these seminal cases. In recent years, we have witnessed a deeper understanding of the etiology of specific phobias and developed a rich array of evidence-based assessments and treatments with which to address specific phobias in youth. Although much has been accomplished in this area of inquiry, we also note that much remains to be done before we can advance more fully our understanding, assessment, and treatment of specific phobias in youth. It will be important for future work to build more firmly on these developments and to better determine the moderators and mediators of change with our evidence-based treatments and to more vigorously pursue their dissemination in real-word settings.

7 CFR Exhibit F to Subpart I of... - Site Option Loan to Technical Assistance Grantees

Code of Federal Regulations, 2012 CFR

2012-01-01

... SO funds advanced on the option, unless SO loan funds will still be needed to purchase other options...) The “kind of loan” block on the note will read “SO loan.” (2) The note will be modified to show that the only installment on the loan will be the final installment. (C) Loan is closed. The loan will be...

7 CFR Exhibit F to Subpart I of... - Site Option Loan to Technical Assistance Grantees

Code of Federal Regulations, 2014 CFR

2014-01-01

... SO funds advanced on the option, unless SO loan funds will still be needed to purchase other options...) The “kind of loan” block on the note will read “SO loan.” (2) The note will be modified to show that the only installment on the loan will be the final installment. (C) Loan is closed. The loan will be...

7 CFR Exhibit F to Subpart I of... - Site Option Loan to Technical Assistance Grantees

Code of Federal Regulations, 2013 CFR

2013-01-01

... SO funds advanced on the option, unless SO loan funds will still be needed to purchase other options...) The “kind of loan” block on the note will read “SO loan.” (2) The note will be modified to show that the only installment on the loan will be the final installment. (C) Loan is closed. The loan will be...

Advanced Spacesuit Informatics Software Design for Power, Avionics and Software Version 2.0

NASA Technical Reports Server (NTRS)

Wright, Theodore W.

2016-01-01

A description of the software design for the 2016 edition of the Informatics computer assembly of the NASAs Advanced Extravehicular Mobility Unit (AEMU), also called the Advanced Spacesuit. The Informatics system is an optional part of the spacesuit assembly. It adds a graphical interface for displaying suit status, timelines, procedures, and warning information. It also provides an interface to the suit mounted camera for recording still images, video, and audio field notes.

The new color of money: safer, smarter, more secure

NASA Astrophysics Data System (ADS)

DiNunzio, Lisa A.; Clarke, Lenore

2004-06-01

Approximately 60% of U.S. currency notes circulate abroad. As the most widely used currency in the world, U.S. notes are the most likely to be counterfeited. Since 1996, the United States has been issuing currency with new security features. These features make U.S. currency easier to recognize as genuine and more secure against advancing computer technology that could be used for counterfeiting. Currency counterfeiters are increasingly turning to digital methods, as advances in technology make digital counterfeiting of currency easier and cheaper. In 1995, for example, less than one percent of counterfeit notes detected in the U.S. were digitally produced. By 2002, that number had grown to nearly 40 percent, according to the Secret Service. Yet despite the efforts of counterfeiters, U.S. currency counterfeiting has been kept at low levels. According to current estimates, between 0.01 and 0.02 percent of notes in circulation are counterfeit, or about 1-2 notes in every 10,000 genuine notes. The strategy for maintaining the security of Federal Reserve notes is to enhance the design of U.S. currency every seven to ten years. One objective of introducing the new currency is to emphasize the number of features available to the public for authenticating bills. The most-talked-about aspect of the redesigned currency is the subtle introduction of background colors to the bills. While color itself is not a security feature, the use of color provides the opportunity to add features that could assist in deterring counterfeiting. Color will also help people to better distinguish their notes. Security features for the newly designed currency include a security thread, a watermark, and a more distinct color-shifting ink. The new 20 note was issued in fall 2003, with the 50 and 100 notes scheduled to follow 12 to 18 months later. Plans to redesign the 10 and 5 are still under consideration, but there are no plans to redesign the 2 and 1 notes. As was the case with the redesigned 20 note issued in 1998, the new design will co-circulate with the current design. As notes return to the Federal Reserve from depository institutions, the Federal Reserve will only destroy the unfit notes introduced since 1998. Designs older than the Series 1996 are destroyed when returned to the Federal Reserve regardless of condition. To ensure a smooth introduction of the new currency, a five-year international public education effort was launched in 2002 to inform the public and target audiences, including financial institutions, law enforcement, and the vending industry of the transition to the new design. The public is the first line of defense against counterfeiting. So, it's important the public has the tools to recognize the new and modified security features in the redesigned notes.

Using language models to identify relevant new information in inpatient clinical notes.

PubMed

Zhang, Rui; Pakhomov, Serguei V; Lee, Janet T; Melton, Genevieve B

2014-01-01

Redundant information in clinical notes within electronic health record (EHR) systems is ubiquitous and may negatively impact the use of these notes by clinicians, and, potentially, the efficiency of patient care delivery. Automated methods to identify redundant versus relevant new information may provide a valuable tool for clinicians to better synthesize patient information and navigate to clinically important details. In this study, we investigated the use of language models for identification of new information in inpatient notes, and evaluated our methods using expert-derived reference standards. The best method achieved precision of 0.743, recall of 0.832 and F1-measure of 0.784. The average proportion of redundant information was similar between inpatient and outpatient progress notes (76.6% (SD=17.3%) and 76.7% (SD=14.0%), respectively). Advanced practice providers tended to have higher rates of redundancy in their notes compared to physicians. Future investigation includes the addition of semantic components and visualization of new information.

Using Language Models to Identify Relevant New Information in Inpatient Clinical Notes

PubMed Central

Zhang, Rui; Pakhomov, Serguei V.; Lee, Janet T.; Melton, Genevieve B.

2014-01-01

Redundant information in clinical notes within electronic health record (EHR) systems is ubiquitous and may negatively impact the use of these notes by clinicians, and, potentially, the efficiency of patient care delivery. Automated methods to identify redundant versus relevant new information may provide a valuable tool for clinicians to better synthesize patient information and navigate to clinically important details. In this study, we investigated the use of language models for identification of new information in inpatient notes, and evaluated our methods using expert-derived reference standards. The best method achieved precision of 0.743, recall of 0.832 and F1-measure of 0.784. The average proportion of redundant information was similar between inpatient and outpatient progress notes (76.6% (SD=17.3%) and 76.7% (SD=14.0%), respectively). Advanced practice providers tended to have higher rates of redundancy in their notes compared to physicians. Future investigation includes the addition of semantic components and visualization of new information. PMID:25954438

The stream segment and stream network temperature models: A self-study course

USGS Publications Warehouse

Bartholow, John M.

2000-01-01

I am pleased to have had the opportunity to revise the first version of this set of course notes for the stream temperature models. In some ways, there have been many changes and in some ways the notes have stayed much the same. Generally, I was satisfied that the notes were both comprehensive and fairly easy to read. The exercises using SSTEMP have been upgraded to reflect advances in the software. Some additional material was added to better cover contemporary thremistors, and some, but not all, weak transitions and incomplete sentences have been corrected. A comprehensive index was added in an attempt to make these notes as useful as possible, and a few telling quotes have been added for spice. The goal has been to make this set of notes as stand-alone as possible and keep the file size down to something that is easily downloadable over the Internet today (March 2000).

Committing to Memory: Memory Prosthetics Show Promise in Helping Those with Neurodegenerative Disorders.

PubMed

Solis, Michele

2017-01-01

Cell phone chimes, sticky notes, even the proverbial string around a finger-these timehonored external cues help guard against our inevitable memory lapses. But some internal help to the brain itself may be on the way in the form of what's being called memory prosthetics. Once considered to be on the fringes of neuroscience, the idea of adding hardware to the brain to help with memory has gathered steam. In 2014, the U.S. Defense Advanced Research Projects Agency (DARPA) made a US$30 million investment in memory prosthetic research as part of the Obama administration's Brain Research through Advancing Innovative Neurotechnologies initiative. In August 2016, Kernel, a startup based in Los Angeles, California, announced its goal to develop a clinical memory device for those debilitated by neurodegenerative disorders such as Alzheimer's disease.

Osteoporosis treatment: recent developments and ongoing challenges

PubMed Central

Khosla, Sundeep; Hofbauer, Lorenz C

2018-01-01

Osteoporosis is an enormous and growing public health problem. Once considered an inevitable consequence of ageing, it is now eminently preventable and treatable. Ironically, despite tremendous therapeutic advances, there is an increasing treatment gap for patients at high fracture risk. In this Series paper, we trace the evolution of drug therapy for osteoporosis, which began in the 1940s with the demonstration by Fuller Albright that treatment with oestrogen could reverse the negative calcium balance that developed in women after menopause or oophorectomy. We note a watershed in osteoporosis drug discovery around the year 2000, when the approach to developing novel therapeutics shifted from one driven by discoveries in animal studies and clinical observations (eg, oestrogen, calcitonin, and teriparatide) or opportunistic repurposing of existing compounds (eg, bisphosphonates) to one driven by advances in fundamental bone biology (eg, denosumab) coupled with clues from patients with rare bone diseases (eg, romosozumab, odanacatib). Despite these remarkable advances, concerns about rare side-effects of anti-resorptive drugs, particularly bisphosphonates, and the absence of clear evidence in support of their long-term efficacy is leading many patients who could benefit from drug therapy to not take these drugs. As such, there remains an important clinical need to develop ways to enhance patient acceptance and compliance with these effective drugs, and to continue to develop new drugs that do not cause these side-effects and have prolonged anabolic effects on bone. Such changes could lead to a true reversal of this potentially devastating disease of ageing. PMID:28689769

Development and evaluation of a de-identification procedure for a case register sourced from mental health electronic records.

PubMed

Fernandes, Andrea C; Cloete, Danielle; Broadbent, Matthew T M; Hayes, Richard D; Chang, Chin-Kuo; Jackson, Richard G; Roberts, Angus; Tsang, Jason; Soncul, Murat; Liebscher, Jennifer; Stewart, Robert; Callard, Felicity

2013-07-11

Electronic health records (EHRs) provide enormous potential for health research but also present data governance challenges. Ensuring de-identification is a pre-requisite for use of EHR data without prior consent. The South London and Maudsley NHS Trust (SLaM), one of the largest secondary mental healthcare providers in Europe, has developed, from its EHRs, a de-identified psychiatric case register, the Clinical Record Interactive Search (CRIS), for secondary research. We describe development, implementation and evaluation of a bespoke de-identification algorithm used to create the register. It is designed to create dictionaries using patient identifiers (PIs) entered into dedicated source fields and then identify, match and mask them (with ZZZZZ) when they appear in medical texts. We deemed this approach would be effective, given high coverage of PI in the dedicated fields and the effectiveness of the masking combined with elements of a security model. We conducted two separate performance tests i) to test performance of the algorithm in masking individual true PIs entered in dedicated fields and then found in text (using 500 patient notes) and ii) to compare the performance of the CRIS pattern matching algorithm with a machine learning algorithm, called the MITRE Identification Scrubber Toolkit - MIST (using 70 patient notes - 50 notes to train, 20 notes to test on). We also report any incidences of potential breaches, defined by occurrences of 3 or more true or apparent PIs in the same patient's notes (and in an additional set of longitudinal notes for 50 patients); and we consider the possibility of inferring information despite de-identification. True PIs were masked with 98.8% precision and 97.6% recall. As anticipated, potential PIs did appear, owing to misspellings entered within the EHRs. We found one potential breach. In a separate performance test, with a different set of notes, CRIS yielded 100% precision and 88.5% recall, while MIST yielded a 95.1% and 78.1%, respectively. We discuss how we overcome the realistic possibility - albeit of low probability - of potential breaches through implementation of the security model. CRIS is a de-identified psychiatric database sourced from EHRs, which protects patient anonymity and maximises data available for research. CRIS demonstrates the advantage of combining an effective de-identification algorithm with a carefully designed security model. The paper advances much needed discussion of EHR de-identification - particularly in relation to criteria to assess de-identification, and considering the contexts of de-identified research databases when assessing the risk of breaches of confidential patient information.

An interstellar precursor mission

NASA Technical Reports Server (NTRS)

Jaffe, L. D.; Ivie, C.; Lewis, J. C.; Lipes, R. G.; Norton, H. N.; Stearns, J. W.; Stimpson, L.; Weissman, P.

1977-01-01

A mission out of the planetary system, with launch about the year 2000, could provide valuable scientific data as well as test some of the technology for a later mission to another star. Primary scientific objectives for the precursor mission concern characteristics of the heliopause, the interstellar medium, stellar distances (by parallax measurements), low energy cosmic rays, interplanetary gas distribution, and mass of the solar system. Secondary objectives include investigation of Pluto. Candidate science instruments are suggested. Individual spacecraft systems for the mission were considered, technology requirements and problem areas noted, and a number of recommendations made for technology study and advanced development. The most critical technology needs include attainment of 50-yr spacecraft lifetime and development of a long-life NEP system.

Rethinking the Postgraduate Teaching Program and Examinations in Today's India.

PubMed

Abraham, Georgi; George, Tarun K

2015-07-01

Postgraduate medical education has undergone drastic changes in the developed and developing countries on par with advancements in technology. The Indian examination system which we imbibed from the British requires a rethinking and restructuring to keep pace with the changing trends shown by the Federation of the Royal Colleges of UK. In this manuscript we look at the strengths and weaknesses of different examination systems. We suggest changes in the theory examination which should be objectively based rather than the outdated essay and short notes. We discuss positive and proactive changes to reform our clinical examination system to enable a just and fair assessment of the candidate in a strictly time bound fashion.

Commentary: the National Workshop to Develop the Chiropractic Research Agenda: 10 years on, a new set of white papers.

PubMed

Lawrence, Dana J; Meeker, William C

2006-01-01

This commentary reports on the advances that have occurred over the 10-year period since the first National Workshop to Develop the Chiropractic Research Agenda was held and introduces the second set of white papers that were produced as a result of the 10th annual Research Agenda Conference. Four working groups were convened to update the original 5 white papers that represented the most significant results from the first workshop in 1996. Each group was to review the first report, examine the action steps and recommendations that were published in each report to see how much had been completed in the past decade, and develop new action steps and recommendations for the future. Four new articles were developed, each updating and adding significant amounts of new research to the original versions. New action steps and recommendations will help move the profession forward into the future. Chiropractic scientists have worked diligently over the past decade to address the recommendations noted in the first set of white papers. Despite significant advances in knowledge and scientific capacity, the chiropractic profession is still confronted with a large number of research challenges.

Reader for Advanced Spoken Tamil, Parts 1 and 2.

ERIC Educational Resources Information Center

Schiffman, Harold F.

Part 1 of this reader consists of transcriptions of five Tamil radio plays, with exercises, notes, and discussion. Part 2 is a synopsis grammar and a glossary. Both are intended for advanced students of Tamil who have had at least two years of instruction in the spoken language at the college level. The materials have been tested in classroom use…

Independent Learning Project for Advanced Chemistry (ILPAC). Teachers' and Technicians' Notes for First Year Units.

ERIC Educational Resources Information Center

Inner London Education Authority (England).

The Independent Learning Project for Advanced Chemistry (ILPAC) has produced units of study for students in A-level chemistry. Students completing ILPAC units assume a greater responsibility for their own learning and can work, to some extent, at their own pace. By providing guidance, and detailed solutions to exercises in the units, supported by…

Case Analyses of Terminally Ill Cancer Patients Who Refused to Sign a Living Will.

ERIC Educational Resources Information Center

Stephens, Ronald L.; Grady, Rosemary

1992-01-01

Notes that, in survey of 50 cancer patients offered living wills, 6 individuals declined to sign advance directives. Contains detailed evaluation of each of six cases. Discusses potential value of living wills in context of other, newer forms of advance directives, such as durable power of attorney for health care, and more detailed living will…

An Investigation of College Students' Perceptions of Advanced Placement® Courses. Research Note 2013-2

ERIC Educational Resources Information Center

Cooney, Siobhan M.; McKillip, Mary E. M.; Smith, Kara

2013-01-01

The present study investigates how current college students perceive their experiences in high school Advanced Placement Program (AP) courses. The goal of this research was twofold: We wanted to not only add to the existing literature on outcomes for AP students but also investigate possible benefits for students without success (i.e., a score of…

Supporting Ngss-Congruent Instruction in Earth & Space Science Through Educator Implementation and Feedback: Refining the Dig Texas Blueprints

NASA Astrophysics Data System (ADS)

Jacobs, B. E.; Bohls-Graham, C. E.; Ellins, K. K.; Riggs, E. M.; Serpa, L. F.; Stocks, E.; McIver, H.; Sergent, C.

2015-12-01

The development of the Next Generation Science Standards (NGSS) as a framework around which to guide K-12 science instruction has generated a call for rigorous curricula that meets the demand for developing a workforce with expertise in tackling modern Earth science challenges. The Diversity and Innovation in Geosciences (DIG) Texas Blueprints project addresses this need for quality, aligned curricula with educator-vetted, freely available resources carefully selected and compiled into three week thematic units that have been aligned with the Earth Science Literacy Principles and the NGSS. These units can then be packaged into customized blueprints for a year-long Earth & Space Science course that engages students in the relevant disciplinary core ideas, crosscutting concepts and science and engineering practices. As part of supporting NGSS-congruent instruction, each unit has extensive scaffolding notes for the learning activities selected for that unit. Designed with both the new and veteran teacher in mind, these scaffolding notes yield information regarding advanced teacher preparation, student prerequisite skills, and potential challenges that might arise during classroom implementation. Feedback from Texas high school teachers implementing the DIG Texas Blueprints in the classroom, in addition to that of university secondary education majors in a preparation course utilizing the blueprints, instigated the most recent revisions to these scaffolding notes. The DIG Texas Blueprints Educator Intern Team charged with these revisions then determined which learning activities became candidates for either inclusion in the refined units, retention as an additional resource, or elimination from the blueprints. This presentation will focus on the development of these scaffolding notes and their role in supporting congruence with the NGSS. A review of the second year of implementation of the blueprints and the feedback that generated the final revisions will be shared, as well as the current accessibility status of the DIG Texas Blueprints resources

A 100-Year Review: A century of dairy processing advancements-Pasteurization, cleaning and sanitation, and sanitary equipment design.

PubMed

Rankin, S A; Bradley, R L; Miller, G; Mildenhall, K B

2017-12-01

Over the past century, advancements within the mainstream dairy foods processing industry have acted in complement with other dairy-affiliated industries to produce a human food that has few rivals with regard to safety, nutrition, and sustainability. These advancements, such as milk pasteurization, may appear commonplace in the context of a modern dairy processing plant, but some consideration of how these advancements came into being serve as a basis for considering what advancements will come to bear on the next century of processing advancements. In the year 1917, depending on where one resided, most milk was presented to the consumer through privately owned dairy animals, small local or regional dairy farms, or small urban commercial dairies with minimal, or at best nascent, processing capabilities. In 1917, much of the retail milk in the United States was packaged and sold in returnable quart-sized clear glass bottles fitted with caps of various design and composition. Some reports suggest that the cost of that quart of milk was approximately 9 cents-an estimated $2.00 in 2017 US dollars. Comparing that 1917 quart of milk to a quart of milk in 2017 suggests several differences in microbiological, compositional, and nutritional value as well as flavor characteristics. Although a more comprehensive timeline of significant processing advancements is noted in the AppendixTable A1 to this paper, we have selected 3 advancements to highlight; namely, the development of milk pasteurization, cleaning and sanitizing technologies, and sanitary specifications for processing equipment. Finally, we provide some insights into the future of milk processing and suggest areas where technological advancements may need continued or strengthened attention and development as a means of securing milk as a food of high safety and value for the next century to come. Copyright © 2017 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

Language in Comparative Perspective. Chapter 11

NASA Technical Reports Server (NTRS)

Rumbaugh, Duane M.; Savage-Rumbaugh, E. Sue

1994-01-01

The twentieth century will be noted for a wide variety of scientific and technological advancements, including powered flight, antibiotics, space travel, and the breaking of the genetic code. It also should be noted as the century in which major psychological, as well as biological, continuities between animal and human have been defined. Charles Darwin (1859) was quite right when he anticipated continuity in mental processes, some of which provide for language. Though none will argue that any animal has the full capacity of humans for language, none should deny that at least some animals have quite impressive competencies for language skills, including speech comprehension. The finding that the language skills in the bonobo and the chimpanzee are likely more fully and efficiently developed as a result of early rearing than by formal training at a later age declares a continuity even stronger than that defined by the language acquisition potential of the ape. To clarify, because early rearing facilitates the emergence of language in ape as well as in child, a naturalness to the familiar course of language acquisition, whereby comprehension precedes production, is also corroborated. In turn, the continuity and the shared naturalness of language acquisition serve jointly to define an advanced and critical point of linkage between the genera Pan and Homo - and, as concluded by Domjan (1993), one worthy of contributing to the series of reconceptions of ourselves as anticipated by Ploog and Melnechuk (1971).

A multimedia perioperative record keeper for clinical research.

PubMed

Perrino, A C; Luther, M A; Phillips, D B; Levin, F L

1996-05-01

To develop a multimedia perioperative recordkeeper that provides: 1. synchronous, real-time acquisition of multimedia data, 2. on-line access to the patient's chart data, and 3. advanced data analysis capabilities through integrated, multimedia database and analysis applications. To minimize cost and development time, the system design utilized industry standard hardware components and graphical. software development tools. The system was configured to use a Pentium PC complemented with a variety of hardware interfaces to external data sources. These sources included physiologic monitors with data in digital, analog, video, and audio as well as paper-based formats. The development process was guided by trials in over 80 clinical cases and by the critiques from numerous users. As a result of this process, a suite of custom software applications were created to meet the design goals. The Perioperative Data Acquisition application manages data collection from a variety of physiological monitors. The Charter application provides for rapid creation of an electronic medical record from the patient's paper-based chart and investigator's notes. The Multimedia Medical Database application provides a relational database for the organization and management of multimedia data. The Triscreen application provides an integrated data analysis environment with simultaneous, full-motion data display. With recent technological advances in PC power, data acquisition hardware, and software development tools, the clinical researcher now has the ability to collect and examine a more complete perioperative record. It is hoped that the description of the MPR and its development process will assist and encourage others to advance these tools for perioperative research.

The effect of age on outcomes after isolated limb perfusion for advanced extremity malignancies.

PubMed

Smith, H G; Wilkinson, M J; Smith, M J F; Strauss, D C; Hayes, A J

2018-06-22

Isolated limb perfusion (ILP) is a well-established treatment for patients with advanced extremity malignancies unsuitable for limb-conserving surgery. However, little is known about the outcomes of this treatment in elderly patients. We sought to determine the effects of age on the tolerability and efficacy of ILP for advanced extremity malignancy. Patients undergoing ILP at our institution between January 2005 and January 2018 were identified from a prospectively maintained database. Patients were stratified by pathology (melanoma, soft-tissue sarcoma, other) and age (<75 years and ≥75 years). Outcomes of interest were perioperative morbidity and mortality, locoregional toxicities, response rates and oncological outcomes. During the study period, a total of 189 perfusions were attempted. Successful perfusions were performed in 179 patients, giving a technical success rate of 94.7%. No difference in perfusion success rates, severe locoregional toxicity and perioperative morbidity or mortality was noted between those aged <75 years and ≥75 years. The overall response rate in melanoma was 82.4%, and no difference in response rates or oncological outcomes between age groups was noted in these patients. The overall response rate in soft-tissue sarcoma was 63.5%, with no difference in response rates noted between age groups. However, patients aged <75 years with soft-tissue sarcoma had prolonged local recurrence-free survival compared with older patients (13 versus 6 months), possibly due to the prevalence of chemosensitive subtypes in the younger age group. ILP is an effective treatment for advanced extremity malignancies in the elderly, with comparable response rates and toxicities to younger patients. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Multimedia reviews: multimedia convergence for clinicians.

PubMed

Taintor, Zebulon

2003-12-01

Introduction by the column editor: In this final column of the year, Dr. Taintor provides an overview of exciting technological developments via his report on the 2003 annual meeting of the American Association for Technology in Psychiatry (AATP). Advances-and convergences-in technology are providing clinicians with increasingly useful tools to enhance the effectiveness of their treatments, increase access to care, reduce errors, and save time. As Dr. Taintor notes, AATP's meeting is traditionally held in conjunction with the annual meeting of the American Psychiatric Association (APA). I hope that his report will encourage APA's members to attend some of next year's informative sessions.

Progress in the development of the reverse osmosis process for spacecraft wash water recovery.

NASA Technical Reports Server (NTRS)

Pecoraro, J. N.; Podall, H. E.; Spurlock, J. M.

1972-01-01

Research work on ambient- and pasteurization-temperature reverse osmosis processes for wash water recovery in a spacecraft environment is reviewed, and the advantages and drawbacks of each are noted. A key requirement in each case is to provide a membrane of appropriate stability and semipermeability. Reverse osmosis systems intended for such use must also take into account the specific limitations and requirements imposed by the small volume of water to be processed and the high water recovery desired. The incorporation of advanced high-temperature membranes into specially designed modules is discussed.

Chreods, homeorhesis and biofields: Finding the right path for science through Daoism.

PubMed

Gare, Arran

2017-12-01

C.H. Waddington's concepts of 'chreods' (canalized paths of development) and 'homeorhesis' (the tendency to return to a path), each associated with 'morphogenetic fields', were conceived by him as a contribution to complexity theory. Subsequent developments in complexity theory have largely ignored Waddington's work and efforts to advance it. Waddington explained the development of the concept of chreod as the influence on his work of Alfred North Whitehead's process philosophy, notably, the concept of concrescence as a self-causing process. Processes were recognized as having their own dynamics, rather than being explicable through their components or external agents. Whitehead recognized the tendency to think only in terms of such 'substances' as a bias of European thought, claiming in his own philosophy 'to approximate more to some strains of Indian, or Chinese, thought, than to western Asiatic, or European, thought.' Significantly, the theoretical biologist who comes closest to advancing Waddington's research program, also marginalized, is Mae-Wan Ho. Noting this bias, and embracing Whitehead's and Waddington's efforts to free biology from assumptions dominating Western thought to advance an ontology of creative causal processes, I will show how later developments of complexity theory, most importantly, Goodwin's work on oscillations, temporality and morphology, Vitiello's dissipative quantum brain dynamics, Salthe's work on hierarchy theory, biosemiotics inspired by Peirce and von Uexküll, Robert Rosen's work on anticipatory systems, together with category theory and biomathics, can augment while being augmented by Waddington's work, while further advancing Mae-Wan Ho's radical research program with its quest to understand the reality of consciousness. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

Medicare program; Part B advance payments to suppliers furnishing items or services under Medicare Part B--HCFA. Final rule.

PubMed

1996-09-19

This rule establishes requirements and procedures for advance payments to suppliers of Medicare Part B services. An advance payment will be made only if the carrier is unable to process a claim timely; the supplier requests advance payment; we determine that payment of interest is insufficient to compensate the supplier for loss of the use of the funds; and, we expressly approve the advance payment in writing. These rules are necessary to address deficiencies noted by the General Accounting Office in its report analyzing current procedures for making advance payments. The intent of this rule is to ensure more efficient and effective administration of this aspect of the Medicare program.

U.S. Army Medical Department Journal, January-March 2006

DTIC Science & Technology

2006-03-01

Commission of Dental available. In 2004, the first Army resident went to the Accreditation (CODA) in association with the Orofacial Pain Fellowship at...the Orofacial Pain American Dental Association (ADA). Advanced Center, Naval Postgraduate Dental School, National training in general dentistry is...presented by orofacial pain patients. Year Advanced Education in General Dentistry Program. DODI 6000.13 notes that "while internship Another

s-Block Elements. Independent Learning Project for Advanced Chemistry (ILPAC). Unit I1.

ERIC Educational Resources Information Center

Inner London Education Authority (England).

This unit is one of 10 first year units produced by the Independent Learning Project for Advanced Chemistry (ILPAC). The unit, which consists of two sections and an appendix, focuses on the elements and compounds of Groups I and II (the s-block) of the periodic table. The groups are treated concurrently to note comparisons between groups and to…

Universal Open Power, Communications, and Control for Assistive Devices

DTIC Science & Technology

2017-10-01

The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the...SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION / AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES...flexible energy configuration, advanced high bandwidth sensing, and high energy density actuation technology. This project will advance the state-of

Private Power for the Public Good. A History of the Carnegie Foundation for the Advancement of Teaching. [Revised.

ERIC Educational Resources Information Center

Lagemann, Ellen Condliffe

This book traces the history of the Carnegie Foundation for the Advancement of Teaching from its founding in 1906 through 1979. A 1999 foreword by the current president of the Foundation notes the influence of the book and briefly updates the foundation's history. The foreword reiterates the book's judgment that the foundation's policies typically…

Challenges of Aircraft Design Integration

DTIC Science & Technology

2003-03-01

predicted by the conceptual stick model and the full FEM of the Challenger wing without winglets . Advanced aerodynamic wing design methods To design wings...Piperni, E. Laurendeau Advanced Aerodynamics Bombardier Aerospace 400 CMte Vertu Road Dorval, Quebec, Canada, H4S 1Y9 Fassi.Kafyeke @notes.canadair.ca Tel...514) 855-7186 Abstract The design of a modern airplane brings together many disciplines: structures, aerodynamics , controls, systems, propulsion

The virulence of human pathogenic fungi: notes from the South of France.

PubMed

Reedy, Jennifer L; Bastidas, Robert J; Heitman, Joseph

2007-08-16

The Second FEBS Advanced Lecture Course on Human Fungal Pathogens: Molecular Mechanisms of Host-Pathogen Interactions and Virulence, organized by Christophe d'Enfert (Institut Pasteur, France), Anita Sil (UCSF, USA), and Steffen Rupp (Fraunhofer, IGB, Germany), occurred May 2007 in La Colle sur Loup, France. Here we review the advances presented and the current state of knowledge in key areas of fungal pathogenesis.

The ethics of using cybernetics and cyborg technologies: what every rehabilitation nurse should know.

PubMed

Moore, Linda Weaver; Rieg, Linda S

2005-01-01

Cybernetics and cyborg technologies are rapidly developing in the field of biotechnology. Such developments have yielded a wide variety of devices and prosthetics that have promoted the quality of life for many individuals with physical limitations and generally have been applauded by society and the rehabilitation field. However, such rapid developments have given rise to multiple ethical concerns. Understanding these ethical concerns and the implications they have for rehabilitation nurses is imperative. While the potential benefits of advances in technology are great for those with disabilities and chronic conditions, ethicists suggest that skepticism must be balanced with the zeal that often accompanies cutting-edge developments. As Hook notes, "We must show not a fear of technology, but a courageous control of technology, and refuse to let technology control us" (2002, p. 67).

Natural language processing of clinical notes for identification of critical limb ischemia.

PubMed

Afzal, Naveed; Mallipeddi, Vishnu Priya; Sohn, Sunghwan; Liu, Hongfang; Chaudhry, Rajeev; Scott, Christopher G; Kullo, Iftikhar J; Arruda-Olson, Adelaide M

2018-03-01

Critical limb ischemia (CLI) is a complication of advanced peripheral artery disease (PAD) with diagnosis based on the presence of clinical signs and symptoms. However, automated identification of cases from electronic health records (EHRs) is challenging due to absence of a single definitive International Classification of Diseases (ICD-9 or ICD-10) code for CLI. In this study, we extend a previously validated natural language processing (NLP) algorithm for PAD identification to develop and validate a subphenotyping NLP algorithm (CLI-NLP) for identification of CLI cases from clinical notes. We compared performance of the CLI-NLP algorithm with CLI-related ICD-9 billing codes. The gold standard for validation was human abstraction of clinical notes from EHRs. Compared to billing codes the CLI-NLP algorithm had higher positive predictive value (PPV) (CLI-NLP 96%, billing codes 67%, p < 0.001), specificity (CLI-NLP 98%, billing codes 74%, p < 0.001) and F1-score (CLI-NLP 90%, billing codes 76%, p < 0.001). The sensitivity of these two methods was similar (CLI-NLP 84%; billing codes 88%; p < 0.12). The CLI-NLP algorithm for identification of CLI from narrative clinical notes in an EHR had excellent PPV and has potential for translation to patient care as it will enable automated identification of CLI cases for quality projects, clinical decision support tools and support a learning healthcare system. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Nonimaging optics

NASA Astrophysics Data System (ADS)

Winston, Roland

1991-03-01

Various uses of nonimaging concentrators and advances in the field of nonimaging optics are discussed. A nonimaging concentrator acts as a type of funnel for light by collecting and intensifying radiation far better than a lens or mirror would. It thus has found useful applications in fields ranging from high-energy physics to solar energy. The history of the field of nonimaging optics is traced, beginning with the design of the first compound parabolic concentrators in the mid-1960s. It is noted that at present there are two known ways to design nonimaging concentrators: the edge-ray method and the geometric vector flux approach. The use of nonimaging optical devices in the design of nontracking solar concentrators is traced. It is noted that the upper limit of concentration turns out to be about 46,000 times the intensity of sunlight at the surface of the earth. Methods used to maximize this concentration are discussed. The development and use of a solar-pumped laser which would have applications in satellite communications are discussed.

Advance care planning: challenges and approaches for pediatricians.

PubMed

Heckford, Emma; Beringer, Antonia Jane

2014-09-01

There is increasing recognition of the value of advance care planning for children with life-limiting conditions. It is important that we acknowledge and reflect on the challenges that this work presents in order to optimize practice. Our aim was to review advance care planning for children with life-threatening or life-limiting conditions (LTLLCs) in our local area. We conducted a retrospective case note review. Study subjects were from two National Health Service (NHS) Trusts in Bristol in the United Kingdom. Cases were identified from Child Death Overview Panel data. Forty-two sets of case notes were reviewed in relation to 20 children. Measurements included quantitative and qualitative review of advance care planning in relation to standards set by The Association for Children's Palliative Care (ACT). In 25% of cases there was no documented discussion with families about the approach to end of life (EOL). In 25% of cases there was no evidence of an advance care plan, and the content and accessibility of those that did exist was variable. Forty-five percent of families were not offered a choice with regard to location of care (LOC) in the last months of life and 50% were not offered a choice about location of death (LOD). We hope that acknowledgement of some of the challenges, alongside recognition of the clear benefits, of planning will help pediatricians to deliver this important area of care.

Satellite Imagery Via Personal Computer

NASA Technical Reports Server (NTRS)

1989-01-01

Automatic Picture Transmission (APT) was incorporated by NASA in the Tiros 8 weather satellite. APT included an advanced satellite camera that immediately transmitted a picture as well as low cost receiving equipment. When an advanced scanning radiometer was later introduced, ground station display equipment would not readily adjust to the new format until GSFC developed an APT Digital Scan Converter that made them compatible. A NASA Technical Note by Goddard's Vermillion and Kamoski described how to build a converter. In 1979, Electro-Services, using this technology, built the first microcomputer weather imaging system in the U.S. The company changed its name to Satellite Data Systems, Inc. and now manufactures the WeatherFax facsimile display graphics system which converts a personal computer into a weather satellite image acquisition and display workstation. Hardware, antennas, receivers, etc. are also offered. Customers include U.S. Weather Service, schools, military, etc.

Wearable and Implantable Mechanical Energy Harvesters for Self-Powered Biomedical Systems.

PubMed

Hinchet, Ronan; Kim, Sang-Woo

2015-08-25

In this issue of ACS Nano, Tang et al. investigate the ability of a triboelectric nanogenerator (TENG) to self-power a low-level laser cure system for osteogenesis by studying the efficiency of a bone remodeling laser treatment that is powered by a skin-patch-like TENG instead of a battery. We outline this field by highlighting the motivations for self-powered biomedical systems and by discussing recent progress in nanogenerators. We note the overlap between biomedical devices and TENGs and their dawning synergy, and we highlight key prospects for future developments. Biomedical systems should be more autonomous. This advance could improve their body integration and fields of action, leading to new medical diagnostics and treatments. However, future self-powered biomedical systems will need to be more flexible, biocompatible, and biodegradable. These advances hold the promise of enabling new smart autonomous biomedical systems and contributing significantly to the Internet of Things.

AGR-5/6/7 LEUCO Kernel Fabrication Readiness Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marshall, Douglas W.; Bailey, Kirk W.

2015-02-01

In preparation for forming low-enriched uranium carbide/oxide (LEUCO) fuel kernels for the Advanced Gas Reactor (AGR) fuel development and qualification program, Idaho National Laboratory conducted an operational readiness review of the Babcock & Wilcox Nuclear Operations Group – Lynchburg (B&W NOG-L) procedures, processes, and equipment from January 14 – January 16, 2015. The readiness review focused on requirements taken from the American Society Mechanical Engineers (ASME) Nuclear Quality Assurance Standard (NQA-1-2008, 1a-2009), a recent occurrence at the B&W NOG-L facility related to preparation of acid-deficient uranyl nitrate solution (ADUN), and a relook at concerns noted in a previous review. Topicmore » areas open for the review were communicated to B&W NOG-L in advance of the on-site visit to facilitate the collection of objective evidences attesting to the state of readiness.« less

Fine particles and oxidant pollution: developing an agenda for cooperative research.

PubMed

Hidy, G M; Hales, J M; Roth, P M; Scheffe, R

2000-04-01

This paper describes a background for the North American Research Strategy for Tropospheric Ozone (NARSTO) cooperative program integrating studies of O3 and PM2.5. It discusses several important aspects for rationalizing NARSTO's trinational investigative approach, including (1) an outlook on the state of knowledge about fine particles in the troposphere and their origins in Canada, Mexico, and the United States; (2) the need for enhancement and strengthening of key field measurements in relation to tropospheric chemistry and a health effects component; and (3) the use of a central theme for advancing air quality modeling using evolving techniques to integrate and guide key process-oriented field campaigns. The importance of organizing a scientific program to acquire "policy-relevant" information is stressed, noting cooperative research directions that address combined PM2.5 and O3 issues, illustrated through exploration of hypothetical pathways of PM2.5 response to choices of O3 and PM precursor emission reductions. The information needed for PM2.5 research is noted to intersect in many cases with those of O3, but diverge in other cases. Accounting for these distinctions is important for developing NARSTO's strategy over the next decade.

Advanced Undergraduate Experiments in Thermoanalytical Chemistry.

ERIC Educational Resources Information Center

Hill, J. O.; Magee, R. J.

1988-01-01

Describes several experiments using the techniques of thermal analysis and thermometric titrimetry. Defines thermal analysis and several recent branches of the technique. Notes most of the experiments use simple equipment and standard laboratory techniques. (MVL)

A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis.

PubMed

Li, Ning; Feng, Lin; Han, Hui-Qiong; Yuan, Jing; Qi, Xue-Kang; Lian, Yi-Fan; Kuang, Bo-Hua; Zhang, Yu-Chen; Deng, Cheng-Cheng; Zhang, Hao-Jiong; Yao, You-Yuan; Xu, Miao; He, Gui-Ping; Zhao, Bing-Chun; Gao, Ling; Feng, Qi-Sheng; Chen, Li-Zhen; Yang, Lu; Yang, Dajun; Zeng, Yi-Xin

2016-10-10

Despite advances in the development of radiation against nasopharyngeal carcinoma (NPC), the management of advanced NPC remains a challenge. Smac mimetics are designed to neutralize inhibitor of apoptosis (IAP) proteins, thus reactivating the apoptotic program in cancer cells. In this study, we investigated the effect of a novel bivalent Smac mimetic APG-1387 in NPC. In vitro, APG-1387 in combination with TNF-α potently decreased NPC cell viability by inducing apoptosis in majority of NPC cell lines. The in vitro antitumor effect was RIPK1-dependent, whereas it was independent on IAPs, USP11, or EBV. Of note, the inhibition of NF-κB or AKT pathway rendered resistant NPC cells responsive to the treatment of APG-1387/TNF-α. In vivo, APG-1387 displayed antitumor activity as a single agent at well-tolerated doses, even in an in vitro resistant cell line. In summary, our results demonstrate that APG-1387 exerts a potent antitumor effect on NPC. These findings support clinical evaluation of APG-1387 as a potential treatment for advanced NPC. Copyright © 2016. Published by Elsevier Ireland Ltd.

Information on the Advanced Plant Experiment (APEX) Test Facility

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, Curtis Lee

The purpose of this report provides information related to the design of the Oregon State University Advanced Plant Experiment (APEX) test facility. Information provided in this report have been pulled from the following information sources: Reference 1: R. Nourgaliev and et.al, "Summary Report on NGSAC (Next-Generation Safety Analysis Code) Development and Testing," Idaho National Laboratory, 2011. Note that this is report has not been released as an external report. Reference 2: O. Stevens, Characterization of the Advanced Plant Experiment (APEX) Passive Residual Heat Removal System Heat Exchanger, Master Thesis, June 1996. Reference 3: J. Reyes, Jr., Q. Wu, and J.more » King, Jr., Scaling Assessment for the Design of the OSU APEX-1000 Test Facility, OSU-APEX-03001 (Rev. 0), May 2003. Reference 4: J. Reyes et al, Final Report of the NRC AP600 Research Conducted at Oregon State University, NUREG/CR-6641, July 1999. Reference 5: K. Welter et al, APEX-1000 Confirmatory Testing to Support AP1000 Design Certification (non-proprietary), NUREG-1826, August 2005.« less

Energy: options for the future. Curriculum development project for high school teachers. Final report. [Packet

DOE Office of Scientific and Technical Information (OSTI.GOV)

Carroll, T.O.

Recent state and regional energy crises demonstrate the delicate balance between energy systems, the environment, and the economy. Indeed, the interaction between these three elements of society is very complex. This project develops curriculum materials that would better provide students with an understanding and awareness of fundamental principles of energy supply, conversion processes, and utilization now and in the future. The project had two specific objectives: to transfer knowledge of energy systems, analysis techniques, and advanced technologies from the energy analyst community to the teacher participants; and to involve teachers in the preparation of modular case studies on energy issuesmore » for use within the classroom. These curriculum modules are intended to enhance the teacher's ability to provide energy-related education to students within his or her own academic setting. The project is organized as a three-week summer program, as noted in the flyer (Appendix A). Mornings are spent in seminars with energy and environmental specialists (their handout lecture notes are included as Appendix B); afternoons are devoted to high school curriculum development based on the seminar discussions. The curriculum development is limited to five areas: conservation, electricity demand scheduling, energy in the food system, new technologies (solar, wind, biomass), and environment. Appendix C consists of one-day lession plans in these areas.« less

UROLOGIC ROBOTS AND FUTURE DIRECTIONS

PubMed Central

Mozer, Pierre; Troccaz, Jocelyne; Stoianovici, Dan

2009-01-01

Purpose of review Robot-assisted laparoscopic surgery in urology has gained immense popularity with the Da Vinci system but a lot of research teams are working on new robots. The purpose of this paper is to review current urologic robots and present future developments directions. Recent findings Future systems are expected to advance in two directions: improvements of remote manipulation robots and developments of image-guided robots. Summary The final goal of robots is to allow safer and more homogeneous outcomes with less variability of surgeon performance, as well as new tools to perform tasks based on medical transcutaneous imaging, in a less invasive way, at lower costs. It is expected that improvements for remote system could be augmented reality, haptic feed back, size reduction and development of new tools for NOTES surgery. The paradigm of image-guided robots is close to a clinical availability and the most advanced robots are presented with end-user technical assessments. It is also notable that the potential of robots lies much further ahead than the accomplishments of the daVinci system. The integration of imaging with robotics holds a substantial promise, because this can accomplish tasks otherwise impossible. Image guided robots have the potential to offer a paradigm shift. PMID:19057227

Development of Tasks and Evaluation of a Prototype Forceps for NOTES

PubMed Central

Addis, Matthew; Aguirre, Milton; Haluck, Randy; Matthew, Abraham; Pauli, Eric; Gopal, Jegan

2012-01-01

Background and Objectives: Few standardized testing procedures exist for instruments intended for Natural Orifice Translumenal Endoscopic Surgery. These testing procedures are critical for evaluating surgical skills and surgical instruments to ensure sufficient quality. This need is widely recognized by endoscopic surgeons as a major hurdle for the advancement of Natural Orifice Translumenal Endoscopic Surgery. Methods: Beginning with tasks currently used to evaluate laparoscopic surgeons and instruments, new tasks were designed to evaluate endoscopic surgical forceps instruments. Results: Six tasks have been developed from existing tasks, adapted and modified for use with endoscopic instruments, or newly designed to test additional features of endoscopic forceps. The new tasks include the Fuzzy Ball Task, Cup Drop Task, Ring Around Task, Material Pull Task, Simulated Biopsy Task, and the Force Gauge Task. These tasks were then used to evaluate the performance of a new forceps instrument designed at Pennsylvania State University. Conclusions: The need for testing procedures for the advancement of Natural Orifice Translumenal Endoscopic Surgery has been addressed in this work. The developed tasks form a basis for not only testing new forceps instruments, but also for evaluating individual performance of surgical candidates with endoscopic forceps instruments. PMID:22906337

Advanced Chemical Propulsion Study

NASA Technical Reports Server (NTRS)

Woodcock, Gordon; Byers, Dave; Alexander, Leslie A.; Krebsbach, Al

2004-01-01

A study was performed of advanced chemical propulsion technology application to space science (Code S) missions. The purpose was to begin the process of selecting chemical propulsion technology advancement activities that would provide greatest benefits to Code S missions. Several missions were selected from Code S planning data, and a range of advanced chemical propulsion options was analyzed to assess capabilities and benefits re these missions. Selected beneficial applications were found for higher-performing bipropellants, gelled propellants, and cryogenic propellants. Technology advancement recommendations included cryocoolers and small turbopump engines for cryogenic propellants; space storable propellants such as LOX-hydrazine; and advanced monopropellants. It was noted that fluorine-bearing oxidizers offer performance gains over more benign oxidizers. Potential benefits were observed for gelled propellants that could be allowed to freeze, then thawed for use.

12 CFR 201.108 - Obligations eligible as collateral for advances.

Code of Federal Regulations, 2011 CFR

2011-01-01

... notes of local urban renewal or public housing agencies fully supported as to principal and interest by...) Obligations entered into by the Secretary of Health, Education, and Welfare under the Public Health Service...

12 CFR 201.108 - Obligations eligible as collateral for advances.

Code of Federal Regulations, 2014 CFR

2014-01-01

... notes of local urban renewal or public housing agencies fully supported as to principal and interest by...) Obligations entered into by the Secretary of Health, Education, and Welfare under the Public Health Service...

12 CFR 201.108 - Obligations eligible as collateral for advances.

Code of Federal Regulations, 2012 CFR

2012-01-01

... notes of local urban renewal or public housing agencies fully supported as to principal and interest by...) Obligations entered into by the Secretary of Health, Education, and Welfare under the Public Health Service...

12 CFR 201.108 - Obligations eligible as collateral for advances.

Code of Federal Regulations, 2013 CFR

2013-01-01

... notes of local urban renewal or public housing agencies fully supported as to principal and interest by...) Obligations entered into by the Secretary of Health, Education, and Welfare under the Public Health Service...

Concrete barrier distress in La Grande, Oregon.

DOT National Transportation Integrated Search

2008-04-01

Several precast concrete barriers in eastern Oregon were noted to be deteriorating at an advanced rate. The ODOT : Research Unit took several core samples from the barriers and conducted analyses. Petrographic evaluations determined : that the strong...

A novel semi-automatic snake robot for natural orifice transluminal endoscopic surgery: preclinical tests in animal and human cadaver models (with video).

PubMed

Son, Jaebum; Cho, Chang Nho; Kim, Kwang Gi; Chang, Tae Young; Jung, Hyunchul; Kim, Sung Chun; Kim, Min-Tae; Yang, Nari; Kim, Tae-Yun; Sohn, Dae Kyung

2015-06-01

Natural orifice transluminal endoscopic surgery (NOTES) is an emerging surgical technique. We aimed to design, create, and evaluate a new semi-automatic snake robot for NOTES. The snake robot employs the characteristics of both a manual endoscope and a multi-segment snake robot. This robot is inserted and retracted manually, like a classical endoscope, while its shape is controlled using embedded robot technology. The feasibility of a prototype robot for NOTES was evaluated in animals and human cadavers. The transverse stiffness and maneuverability of the snake robot appeared satisfactory. It could be advanced through the anus as far as the peritoneal cavity without any injury to adjacent organs. Preclinical tests showed that the device could navigate the peritoneal cavity. The snake robot has advantages of high transverse force and intuitive control. This new robot may be clinically superior to conventional tools for transanal NOTES.

Potential applications of advanced aircraft in developing countries. [Brazil and Indonesia

NASA Technical Reports Server (NTRS)

Maddalon, D. V.

1979-01-01

Air transportation concepts for movement of cargo in developing countries are reviewed using aicraft which may appear in the future. For certain industrial applications, including mining and forestry, the relative costs of doing the job using different types of aircraft are compared with surface transportation systems. Two developing countries, Brazil and Indonesia, were taken as examples to determine what impact they might have on the aircraft markets of the future. Economic and demographic data on developing countries in general, and Brazil and Indonesia in particular, are reviewed. The concept of an industrial city in a remote area developed around an airport is discussed. It is noted that developing areas generally lack extensive surface transportation systems and that an air transportation system can be implemented in a relatively short time. A developing nation interested in rapid expansion may thus find the role of air cargo far more important than has been true in developed nations. Technological developments which may dramatically increase the performance of agricultural aircraft are also reviewed.

Translating stem cell therapies: the role of companion animals in regenerative medicine

PubMed Central

Volk, Susan W.; Theoret, Christine

2013-01-01

Veterinarians and veterinary medicine have been integral to the development of stem cell therapies. The contributions of large animal experimental models to the development and refinement of modern hematopoietic stem cell transplantation were noted nearly five decades ago. More recent advances in adult stem cell/regenerative cell therapies continue to expand knowledge of the basic biology and clinical applications of stem cells. A relatively liberal legal and ethical regulation of stem cell research in veterinary medicine has facilitated the development and in some instances clinical translation of a variety of cell-based therapies involving hematopoietic (HSC) and mesenchymal stem cells (MSC) as well as other adult regenerative cells and recently embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). In fact, many of the pioneering developments in these fields of stem cell research have been achieved through collaborations of veterinary and human scientists. This review aims to provide an overview of the contribution of large animal veterinary models in advancing stem cell therapies for both human and clinical veterinary applications. Moreover, in the context of the “One Health Initiative”, the role veterinary patients may play in the future evolution of stem cell therapies for both human and animal patients will be explored. PMID:23627495

Fbis report. Science and technology: China, October 18, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1995-10-18

;Partial Contents: Nanomaterials Fabrication, Applications Research Advances Noted; CAST Announces World`s First Space-Grown Large-Diameter GaAs Monocrystal; Assay of Antiviral Activity of Antisense Phosphorothioate Oligodeoxynucleotide Against Dengue Virus; Expression and Antigenicity of Chimeric Proteins of Cholera Toxin B Subunit With Hepatitis C Virus; CNCOFIEC Signs Agreement With IBM for New Intelligent Building; Latest Reports on Optical Computing, Memory; BIDC To Introduce S3 Company`s Multimedia Accelerator Chipset; Virtual Private PCN Ring Network Based on ATM VP Cross-Connection; Beijing Gets Nation`s First Frame Relay Network; Situation of Power Industry Development and International Cooperation; Diagrams of China`s Nuclear Waste Containment Vessels; Chinese-Developed Containment Vesselmore » Material Reaches World Standards; Second Fuel Elements for Qinshan Plant Passes Inspection; and Geothermal Deep-Well Electric Pump Technology Developed.« less

GenomicDataCommonsNewsNote

Cancer.gov

NCI is establishing the Genomic Data Commons to store, analyze and distribute cancer genomics data generated by NCI and other research organizations. The GDC will provide an interactive system for researchers to access data, with the goal of advancing the

Contact Us | DOE Data Explorer

Science.gov Websites

advance. Your help is appreciated. Email ddecomments@osti.gov NOTE: Email messages are answered Monday . Javascript Not Enabled Email Link ddecomments@osti.gov Back to top U.S. Department of Energy Office of

GeMS: an advanced software package for designing synthetic genes.

PubMed

Jayaraj, Sebastian; Reid, Ralph; Santi, Daniel V

2005-01-01

A user-friendly, advanced software package for gene design is described. The software comprises an integrated suite of programs-also provided as stand-alone tools-that automatically performs the following tasks in gene design: restriction site prediction, codon optimization for any expression host, restriction site inclusion and exclusion, separation of long sequences into synthesizable fragments, T(m) and stem-loop determinations, optimal oligonucleotide component design and design verification/error-checking. The output is a complete design report and a list of optimized oligonucleotides to be prepared for subsequent gene synthesis. The user interface accommodates both inexperienced and experienced users. For inexperienced users, explanatory notes are provided such that detailed instructions are not necessary; for experienced users, a streamlined interface is provided without such notes. The software has been extensively tested in the design and successful synthesis of over 400 kb of genes, many of which exceeded 5 kb in length.

FDA and NIST collaboration on standards development activities supporting innovation and translation of regenerative medicine products.

PubMed

Arcidiacono, Judith A; Bauer, Steven R; Kaplan, David S; Allocca, Clare M; Sarkar, Sumona; Lin-Gibson, Sheng

2018-06-01

The development of standards for the field of regenerative medicine has been noted as a high priority by several road-mapping activities. Additionally, the U.S. Congress recognizes the importance of standards in the 21st Century Cure Act. Standards will help to accelerate and streamline cell and gene therapy product development, ensure the quality and consistency of processes and products, and facilitate their regulatory approval. Although there is general agreement for the need of additional standards for regenerative medicine products, a shared understanding of standards is required for real progress toward the development of standards to advance regenerative medicine. Here, we describe the roles of standards in regenerative medicine as well as the process for standards development and the interactions of different entities in the standards development process. Highlighted are recent coordinated efforts between the U.S. Food and Drug Administration and the National Institute of Standards and Technology to facilitate standards development and foster science that underpins standards development. Published by Elsevier Inc.

Spectral Domain Optical Coherence Tomographic Findings of Bietti Crystalline Dystrophy

PubMed Central

Öner, Ferit Hakan

2014-01-01

We analyzed the OCT features of 24 eyes of 12 patients with Bietti crystalline dystrophy (BCD) with the Heidelberg HRA2-OCT. Seventeen of 24 eyes were in intermediate stage of the disease and seven in advanced stage of the disease at the time of latest OCT examination performed in 2014. Outer retinal tubulations and retinal hyperreflective dots were present in 20 of 24 eyes. The remaining four eyes had advanced disease with very thin retina. Appearance of bright plaque on top of RPE-Bruch membrane was present in all eyes. Choroidal hyperreflective spots were noted in 19 of 24 eyes. The remaining five eyes had advanced disease stage with very thin choroid. Mean central macular thickness was 163.08 μm ± 62.52 for all eyes (170.35 μm ± 56.46 in eyes with intermediate disease and 145.42 μm ± 77.2 in eyes with advanced disease). Mean subfoveal choroidal thickness was 95.37 μm ± 55.93 for the study eyes (116.47 ± 46.92 μm in eyes with intermediate disease and 44.14 μm ± 42.43 in eyes with advanced disease). Choroidal hyperreflective spots were noted in 21 of 24 eyes (87.5%). SD-OCT shows the disease progression in retinal and choroidal layers delicately in eyes with BCD and expands our knowledge about the ongoing disease process. PMID:25505979

European Science Notes, volume 40, number 2

NASA Astrophysics Data System (ADS)

Shaffer, L. E.

1986-02-01

ESN is a monthly publication with brief articles on recent developments in European scientific research. Its partial contents are: Biotechnology Research at GBF, and at the Inst. of Technical Chemistry, Univ. of Hanover, West Germany; 7th European Immunology Congress; Biotechnia '85 - First International Congress for Biotechnology; Acoustic Cavitation Generated by Clinical Ultrasound; Advances in Chemical Reaction Dynamics; Geophysics Research in Israel; Fiber Composite Research at Paisley College of Technology, Scotland; A review of International Research on the Physical Metallurgy of Welding; Silicon Metallurgy at the Helsinki Technical Univ.; A Conference on Guided Optical Structures and Their Applications; Optoelectronics Research at Oxford Univ.; and Fractal Conferences in Europe.

End-Stage Renal Disease From Cast Nephropathy in a Teenager With Neuroendocrine Carcinoma.

PubMed

Butani, Lavjay; Ducore, Jonathan

2016-07-01

Cast nephropathy is the most common manifestation of renal injury in patients with multiple myeloma but is rarely reported in other conditions. We are reporting our experience in caring for a teenager with a metastatic neuroendocrine carcinoma who developed rapidly progressive kidney injury that advanced to end-stage renal disease. On renal biopsy extensive tubular necrosis and intratubular eosinophilic casts were noted. This previously unreported finding should prompt oncologists to closely monitor for such a complication in patients with secretory tumors. Whether early plasmapheresis could be of benefit, as has been tried in multiple myeloma, remains to be determined.

Human exploration of space and power development

NASA Technical Reports Server (NTRS)

Cohen, Aaron

1991-01-01

Reasons for mounting the Space Exploration Initiative, the variables facing U.S. planners, and the developmental technologies that will be needed to support this initiative are discussed. The three more advanced technological approaches in the field of power generation described include a lunar-based solar power system, a geosynchronous-based earth orbit solar power satellite system, and the utilization of helium-3/deuterium fusion reaction to create a nuclear fuel cycle. It is noted that the major elements of the SEI will include a heavy-lift launch vehicle, a transfer vehicle and a descent/ascent vehicle for use on lunar missions and adaptable to Mars exploration.

Cognitive network organization and cockpit automation

NASA Technical Reports Server (NTRS)

Roske-Hofstrand, R. J.; Paap, K. R.

1985-01-01

Attention is given to a technique for the derivation of pilot cognitive networks from empirical data, which has been successfully used to guide the redesign of the Control Display Unit that serves as the primary interface of the complex flight management system being developed by NASA's Advanced Concepts Flight Simulator program. The 'pathfinder' algorithm of Schvaneveldt et al. (1985) is used to obtain the conceptual organization of four pilots by generating a family of link-weighted networks from a set of psychological distance data derived through similarity ratings. The degree of conceptual agreement between pilots is assessed, and the means of translating a cognitive network into a menu structure are noted.

Radar cross section lectures

NASA Astrophysics Data System (ADS)

Fuhs, A. E.

A comprehensive account is given of the principles that can be applied in military aircraft configuration studies to minimize the radar cross section (RCS) that will be presented by the resulting design to advanced radars under various mission circumstances. It is noted that, while certain ECM techniques can be nullified by improved enemy electronics in a very short time, RCS reductions may require as much as a decade of radar development before prior levels of detectability can be reestablished by enemy defenses. Attention is given to RCS magnitude determinants, inverse scattering, the polarization and scattering matrix, the RCSs of flat plates and conducting cylinders, and antenna geometry and beam patterns.

Note: A novel method for in situ loading of gases via x-ray induced chemistry

NASA Astrophysics Data System (ADS)

Pravica, Michael; Bai, Ligang; Park, Changyong; Liu, Yu; Galley, Martin; Robinson, John; Bhattacharya, Neelanjan

2011-10-01

We have developed and demonstrated a novel method to load oxygen in a sealed diamond anvil cell via the x-ray induced decomposition of potassium chlorate. By irradiating a pressurized sample of an oxidizer (KClO3) with either monochromatic or white beam x-rays from the Advanced Photon Source at ambient temperature and variable pressure, we succeeded in creating a localized region of molecular oxygen surrounded by unreacted sample which was confirmed via Raman spectroscopy. We anticipate that this technique will be useful in loading even more challenging, difficult-to-load gases such as hydrogen and also to load multiple gases.

Note: A novel method for in situ loading of gases via x-ray induced chemistry.

PubMed

Pravica, Michael; Bai, Ligang; Park, Changyong; Liu, Yu; Galley, Martin; Robinson, John; Bhattacharya, Neelanjan

2011-10-01

We have developed and demonstrated a novel method to load oxygen in a sealed diamond anvil cell via the x-ray induced decomposition of potassium chlorate. By irradiating a pressurized sample of an oxidizer (KClO(3)) with either monochromatic or white beam x-rays from the Advanced Photon Source at ambient temperature and variable pressure, we succeeded in creating a localized region of molecular oxygen surrounded by unreacted sample which was confirmed via Raman spectroscopy. We anticipate that this technique will be useful in loading even more challenging, difficult-to-load gases such as hydrogen and also to load multiple gases.

22 CFR 230.02 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.02 Definitions... International Development or its successor. (b) Eligible Note(s) means [a] Note[s] meeting the eligibility...

22 CFR 230.02 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.02 Definitions... International Development or its successor. (b) Eligible Note(s) means [a] Note[s] meeting the eligibility...

22 CFR 230.02 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUB. L. 108-11-STANDARD TERMS AND CONDITIONS § 230.02 Definitions... International Development or its successor. (b) Eligible Note(s) means [a] Note[s] meeting the eligibility...

Adapting Short of Doctrine: US Military Counterinsurgency in Iraq March 2004-December 2006

DTIC Science & Technology

2017-05-25

by MAJ Darrell E. Fawley US Army School of Advanced Military Studies United States Army Command and General Staff College Fort Leavenworth, Kansas...AGENCY NAME(S) AND ADDRESS(ES) Advanced Military Studies Program 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION...AVAILABILITY STATEMENT Approved for Public Release; Distribution is Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT This study argues that officers

Video. Natural Orifice Translumenal Endoscopic Surgery with a miniature in vivo surgical robot.

PubMed

Lehman, Amy C; Dumpert, Jason; Wood, Nathan A; Visty, Abigail Q; Farritor, Shane M; Varnell, Brandon; Oleynikov, Dmitry

2009-07-01

The application of flexible endoscopy tools for Natural Orifice Translumenal Endoscopic Surgery (NOTES) is constrained due to limitations in dexterity, instrument insertion, navigation, visualization, and retraction. Miniature endolumenal robots can mitigate these constraints by providing a stable platform for visualization and dexterous manipulation. This video demonstrates the feasibility of using an endolumenal miniature robot to improve vision and to apply off-axis forces for task assistance in NOTES procedures. A two-armed miniature in vivo robot has been developed for NOTES. The robot is remotely controlled, has on-board cameras for guidance, and grasper and cautery end effectors for manipulation. Two basic configurations of the robot allow for flexibility during insertion and rigidity for visualization and tissue manipulation. Embedded magnets in the body of the robot and in an exterior surgical console are used for attaching the robot to the interior abdominal wall. This enables the surgeon to arbitrarily position the robot throughout a procedure. The visualization and task assistance capabilities of the miniature robot were demonstrated in a nonsurvivable NOTES procedure in a porcine model. An endoscope was used to create a transgastric incision and advance an overtube into the peritoneal cavity. The robot was then inserted through the overtube and into the peritoneal cavity using an endoscope. The surgeon successfully used the robot to explore the peritoneum and perform small-bowel dissection. This study has demonstrated the feasibility of inserting an endolumenal robot per os. Once deployed, the robot provided visualization and dexterous capabilities from multiple orientations. Further miniaturization and increased dexterity will enhance future capabilities.

WDR26 in Advanced Breast Cancer: A Novel Regulator of the P13K/AKT Pathway

DTIC Science & Technology

2017-10-01

AWARD NUMBER: W81XWH-14-1-0539 TITLE: WDR26 in Advanced Breast Cancer : A Novel Regulator of the P13K/ AKT Pathway PRINCIPAL INVESTIGATOR...SUBTITLE 5a. CONTRACT NUMBER WDR26 in Advanced Breast Cancer : A Novel Regulator of the P13K/AKT Pathway 5b. GRANT NUMBER W81XWH-14-1-0539 5c. PROGRAM...NOTES 14. ABSTRACT The PI3K/AKT pathway is one of the most deregulated pathways in breast cancers (>70%), and a major contributor to tumor progression

Biotechnology Computing: Information Science for the Era of Molecular Medicine.

ERIC Educational Resources Information Center

Masys, Daniel R.

1989-01-01

The evolution from classical genetics to biotechnology, an area of research involving key macromolecules in living cells, is chronicled and the current state of biotechnology is described, noting related advances in computing and clinical medicine. (MSE)

The effects of partial sleep restriction and altered sleep timing on appetite and food reward.

PubMed

McNeil, Jessica; Forest, Geneviève; Hintze, Luzia Jaeger; Brunet, Jean-François; Finlayson, Graham; Blundell, John E; Doucet, Éric

2017-02-01

We examined the effects of partial sleep restriction (PSR) with an advanced wake-time or delayed bedtime on measures of appetite, food reward and subsequent energy intake (EI). Twelve men and 6 women (age: 23 ± 4 years, body fat: 18.8 ± 10.1%) participated in 3 randomized crossover sessions: control (habitual bed- and wake-time), 50% PSR with an advanced wake-time and 50% PSR with a delayed bedtime. Outcome variables included sleep architecture (polysomnography), ad libitum EI (validated food menu), appetite sensations (visual analogue scales), satiety quotient (SQ; mm/100 kcal) and food reward (Leeds Food Preference Questionnaire and the relative-reinforcing value (RRV) of preferred food task). Increased fasting and post-standard breakfast appetite ratings were noted following PSR with an advanced wake-time compared to the control and PSR with a delayed bedtime sessions (Fasting hunger ratings: 77 ± 16 vs. 65 ± 18 and 64 ± 16; P = 0.01; Post-meal hunger AUC: 5982 ± 1781 vs. 4508 ± 2136 and 5198 ± 2201; P = 0.03). Increased explicit wanting and liking for high- relative to low-fat foods were also noted during the advanced wake-time vs. control session (Explicit wanting: -3.5 ± 12.5 vs. -9.3 ± 8.9, P = 0.01; Explicit liking: -1.6 ± 8.5 vs. -7.8 ± 9.6, P = 0.002). No differences in the RRV of preferred food, SQ and ad libitum lunch intake were noted between sessions. These findings suggest that appetite sensations and food reward are increased following PSR with an advanced wake-time, rather than delayed bedtime, vs. However, this did not translate into increased EI during a test meal. Given the increasing prevalence of shift workers and incidences of sleep disorders, additional studies are needed to evaluate the prolonged effects of voluntary sleep restriction with altered sleep timing on appetite and EI measurements. Copyright © 2016 Elsevier Ltd. All rights reserved.

Construction Productivity Advancement Research (CPAR) Program: Improved Materials and Processes for Sealing and Resealing Joints in Portland Cement Concrete Pavements - Field Evaluation

DTIC Science & Technology

1993-10-01

sealant was determined by noting the type and number of defects each sealant incurred. Figure 4 provides a sample evaluation sheet used dur- ing the field...was conducted by visually inspect- ing the mater~al for defects . If any defects were noted, the type of defect was described and the quant~ty of that... defect was measured. The quantity of the defect was dividted by the total quantity of sealant and the result reported as percent defect . Adhesion and

The design and development of transonic multistage compressors

NASA Technical Reports Server (NTRS)

Ball, C. L.; Steinke, R. J.; Newman, F. A.

1988-01-01

The development of the transonic multistage compressor is reviewed. Changing trends in design and performance parameters are noted. These changes are related to advances in compressor aerodynamics, computational fluid mechanics and other enabling technologies. The parameters normally given to the designer and those that need to be established during the design process are identified. Criteria and procedures used in the selection of these parameters are presented. The selection of tip speed, aerodynamic loading, flowpath geometry, incidence and deviation angles, blade/vane geometry, blade/vane solidity, stage reaction, aerodynamic blockage, inlet flow per unit annulus area, stage/overall velocity ratio, and aerodynamic losses are considered. Trends in these parameters both spanwise and axially through the machine are highlighted. The effects of flow mixing and methods for accounting for the mixing in the design process are discussed.

Evaluation of early efficacy endpoints for proof-of-concept trials.

PubMed

Chen, Cong; Sun, Linda; Li, Chih-Lin

2013-03-11

A Phase II proof-of-concept (POC) trial usually uses an early efficacy endpoint other than a clinical endpoint as the primary endpoint. Because of the advancement in bioscience and technology, which has yielded a number of new surrogate biomarkers, drug developers often have more candidate endpoints to choose from than they can handle. As a result, selection of endpoint and its effect size as well as choice of type I/II error rates are often at the center of heated debates in design of POC trials. While optimization of the trade-off between benefit and cost is the implicit objective in such a decision-making process, it is seldom explicitly accounted for in practice. In this research note, motivated by real examples from the oncology field, we provide practical measures for evaluation of early efficacy endpoints (E4) for POC trials. We further provide optimal design strategies for POC trials that include optimal Go-No Go decision criteria for initiation of Phase III and optimal resource allocation strategies for conducting multiple POC trials in a portfolio under fixed resources. Although oncology is used for illustration purpose, the same idea developed in this research note also applies to similar situations in other therapeutic areas or in early-stage drug development in that a Go-No Go decision has to rely on limited data from an early efficacy endpoint and cost-effectiveness is the main concern.

Donor lymphocyte infusions in adolescents and young adults for control of advanced pediatric sarcoma.

PubMed

Schober, Sebastian J; von Luettichau, Irene; Wawer, Angela; Steinhauser, Maximilian; Salat, Christoph; Schwinger, Wolfgang; Ussowicz, Marek; Antunovic, Petar; Castagna, Luca; Kolb, Hans-Jochem; Burdach, Stefan E G; Thiel, Uwe

2018-04-27

Allogeneic stem cell transplantation (allo-SCT) and donor lymphocyte infusions (DLI) may induce a graft-versus-tumor effect in pediatric sarcoma patients. Here, we describe general feasibility, toxicity and efficacy of DLI after allo-SCT. 4 of 8 patients responded. ES#4 had stable disease (SD) for 9 months after DLI and RMS#4 partial response for 8 months with combined hyperthermia/chemotherapy. In ES#4, DLI led to SD for 6 months and reverted residual disease before allo-SCT into complete remission. After DLI, ES#4 and RMS#4 developed acute GvHD (°III-°IV), ES#4 also developed chronic GvHD. 5 patients including ES#4 lived longer than expected. Median survival after allo-SCT was 2.3 years, post-relapse survival (PRS) was 13 months. Off note, HLA-mismatched DLI were associated with a trend towards increased survival after allo-SCT and increased PRS compared to HLA-matched DLI (23 versus 3 months). We studied eight adolescents and young adults (AYAs) with advanced Ewing sarcoma (ES#1-4) and rhabdomyosarcoma (RMS#1-4) who received DLI. Escalating doses ranged from 2.5 × 10 4 to 1 × 10 8 CD3 + cells/kg body weight. AYAs were evaluated for response to DLI, graft-versus-host disease (GvHD) and survival. DLI after allo-SCT may control advanced pediatric sarcoma in AYAs with controllable toxicity.

Understanding interdisciplinary health care teams: using simulation design processes from the Air Carrier Advanced Qualification Program to identify and train critical teamwork skills.

PubMed

Hamman, William R; Beaudin-Seiler, Beth M; Beaubien, Jeffrey M

2010-09-01

In the report "Five Years After 'To Err is Human' ", it was noted that "the combination of complexity, professional fragmentation, and a tradition of individualism, enhanced by a well-entrenched hierarchical authority structure and diffuse accountability, forms a daunting barrier to creating the habits and beliefs of common purpose, teamwork, and individual accountability for successful interdependence that a safe culture requires". Training physicians, nurses, and other professionals to work in teams is a concept that has been promoted by many patient safety experts. However the model of teamwork in healthcare is diffusely defined, no clear performance metrics have been established, and the use of simulation to train teams has been suboptimal. This paper reports on the first three years of work performed in the Michigan Economic Development Corporation (MEDC) Tri-Corridor life science grant to apply concepts and processes of simulation design that were developed in the air carrier industry to understand and train healthcare teams. This work has been monitored by the American Academy for the Advancement of Science (AAA) and is based on concepts designed in the Advanced Qualification Program (AQP) from the air carrier industry, which trains and assesses teamwork skills in the same manner as technical skills. This grant has formed the foundation for the Center of Excellence for Simulation Education and Research (CESR).

Virtual reality, robotics, and other wizardry in 21st century trauma care.

PubMed

Maniscalco-Theberge, M E; Elliott, D C

1999-12-01

The former Special Assistant to the Director on Biomedical Technology, Defense Advanced Research Projects Agency (DARPA), COL RM Satava, notes "Predicting the future trends in any profession jeopardizes the credibility of the author." Thus, we have attempted to outline current systems and prototype models in testing phases. Technologic advances will enable enhanced care of trauma patients. In the acute care setting, they also will affect the educational system in theory and practice.

Editorial note

NASA Astrophysics Data System (ADS)

Degueldre, Claude; Lee, Bill; Oversby, Virginia; van Walle, Eric

2009-03-01

The 3rd Symposium N on Nuclear Materials of the European Material Research Society (EMRS) held at the EMRS 08 Spring meeting; Strasbourg - May 26-30, 2008, involved 125 experts from 19 countries dealing with specific nuclear topics in the following sessions: Materials for advanced fusion systems.

A silent yet radical future revolution: Winnicott's innovative perspective.

PubMed

Fabozzi, Paolo

2012-07-01

The author begins with an examination of two unpublished notes by Melanie Klein, written in 1953 and tracked down by Hinshelwood (2008). In these notes, the role of the study of projective identification as a tool that can permit the analyst to master countertransferential difficulties is highlighted; in 1953, this is the most advanced point of psychoanalytic investigations into unconscious object relations. The author also considers Winnicott's essays "Primitive Emotional Development" (1945) and "Hate in the Countertransference" (1947). In the former, Winnicott begins to inquire into the relationship between subjectivity and objectivity, in relation both to the birth of the mind and to the analyst's psychic functioning. Ultimately, the author demonstrates that the origins of an extraordinary transformation of psychoanalytic theory are contained in Winnicott's essay on countertransference of 1947. In fact, the Winnicottian conception of psychic functioning is founded on the radical and absolutely innovative principle by which the object's unconscious functioning, as well as its transformations caused by the subject's unconscious, must be investigated and transformed in order for the subject to be capable of beginning a psychic transformation.

[Education in anatomy initiated by Pompe van Meerdervoort].

PubMed

Koji, Takehiko; Aikawa, Tadaomi

2008-12-01

Pompe van Meerdervoort arrived at Nagasaki port on September 21, 1857 and started his western-style medical education for the first time in the Nishiyakusho of Nagasaki on November 12, 1857. He had 12 students including Ryojun Matsumono. The curriculum was largely based on that of Utrecht Army Medical School, which was re-organized after 1841 and very good in balance of theory and practice. Among subjects, much attention was paid for Anatomy which was quite advancing at the time and in fact the lecture was given on every Tuesday, Thursday and Saturday morning from 1857 to the end of 1859. His lecture note on Anatomy was based on Handboek der Ontleedkunde van den Mensch originally written by C. E. Bock, which was translated into Dutch by P. H. Pool. The note currently available is a copy by the students. In Europe of those days, microscopes were developed and "Histology" had been established as a new science. Therefore, his lecture contained details of histological findings and now we can appreciate his policy to think much of Anatomy in the introduction of western-style medical education.

Banknote authentication using chaotic elements technology

NASA Astrophysics Data System (ADS)

Ambadiyil, Sajan; P. S., Krishnendu; Mahadevan Pillai, V. P.; Prabhu, Radhakrishna

2017-10-01

The counterfeit banknote is a growing threat to the society since the advancements in the field of computers, scanners and photocopiers, as they have made the duplication process for banknote much simpler. The fake note detection systems developed so far have many drawbacks such as high cost, poor accuracy, unavailability, lack of user-friendliness and lower effectiveness. One possible solution to this problem could be the use of a system uniquely linked to the banknote itself. In this paper, we present a unique identification and authentication process for the banknote using chaotic elements embedded in it. A chaotic element means that the physical elements are formed from a random process independent from human intervention. The chaotic elements used in this paper are the random distribution patterns of such security fibres set into the paper pulp. A unique ID is generated from the fibre pattern obtained from UV image of the note, which can be verified by any person who receives the banknote to decide whether the banknote is authentic or not. Performance analysis of the system is also studied in this paper.

Recent advances in diagnostic testing for gastroesophageal reflux disease.

PubMed

Naik, Rishi D; Vaezi, Michael F

2017-06-01

Gastroesophageal reflux disease (GERD) has a large economic burden with important complications that include esophagitis, Barrett's esophagus, and adenocarcinoma. Despite endoscopy, validated patient questionnaires, and traditional ambulatory pH monitoring, the diagnosis of GERD continues to be challenging. Areas covered: This review will explore the difficulties in diagnosing GERD with a focus on new developments, ranging from basic fundamental changes (histology and immunohistochemistry) to direct patient care (narrow-band imaging, impedance, and response to anti-reflux surgery). We searched PubMed using the noted keywords. We included data from full-text articles published in English. Further relevant articles were identified from the reference lists of review articles. Expert commentary: Important advances in novel parameters in intraluminal impedance monitoring such as baseline impedance monitoring has created some insight into alternative diagnostic strategies in GERD. Recent advances in endoscopic assessment of esophageal epithelial integrity via mucosal impedance measurement is questioning the paradigm of prolonged ambulatory testing for GERD. The future of reflux diagnosis may very well be without the need for currently employed technologies and could be as simple as assessing changes in epithelia integrity as a surrogate marker for GERD. However, future studies must validate such an approach.

Application of wireless power transmission systems in wireless capsule endoscopy: an overview.

PubMed

Basar, Md Rubel; Ahmad, Mohd Yazed; Cho, Jongman; Ibrahim, Fatimah

2014-06-19

Wireless capsule endoscopy (WCE) is a promising technology for direct diagnosis of the entire small bowel to detect lethal diseases, including cancer and obscure gastrointestinal bleeding (OGIB). To improve the quality of diagnosis, some vital specifications of WCE such as image resolution, frame rate and working time need to be improved. Additionally, future multi-functioning robotic capsule endoscopy (RCE) units may utilize advanced features such as active system control over capsule motion, drug delivery systems, semi-surgical tools and biopsy. However, the inclusion of the above advanced features demands additional power that make conventional power source methods impractical. In this regards, wireless power transmission (WPT) system has received attention among researchers to overcome this problem. Systematic reviews on techniques of using WPT for WCE are limited, especially when involving the recent technological advancements. This paper aims to fill that gap by providing a systematic review with emphasis on the aspects related to the amount of transmitted power, the power transmission efficiency, the system stability and patient safety. It is noted that, thus far the development of WPT system for this WCE application is still in initial stage and there is room for improvements, especially involving system efficiency, stability, and the patient safety aspects.

Oil-Free Rotor Support Technologies for Long Life, Closed Cycle Brayton Turbines

NASA Technical Reports Server (NTRS)

Lucero, John M.; DellaCorte, Christopher

2004-01-01

The goal of this study is to provide technological support to ensure successful life and operation of a 50-300 kW dynamic power conversion system specifically with response to the rotor support system. By utilizing technical expertise in tribology, bearings, rotordynamic, solid lubricant coatings and extensive test facilities, valuable input for mission success is provided. A discussion of the history of closed cycle Brayton turboalternators (TA) will be included. This includes the 2 kW Mini-Brayton Rotating Unit (Mini-BRU), the 10kW Brayton Rotating Unit (BRU) and the 125 kW turboalternator-compressor (TAC) designed in mid 1970's. Also included is the development of air-cycle machines and terrestrial oil-free gas turbine power systems in the form of microturbines, specifically Capstone microturbines. A short discussion of the self-acting compliant surface hydrodynamic fluid film bearings, or foil bearings, will follow, including a short history of the load capacity advances, the NASA coatings advancements as well as design model advances. Successes in terrestrial based machines will be noted and NASA tribology and bearing research test facilities will be described. Finally, implementation of a four step integration process will be included in the discussion.

Advance Directives as Support of Autonomy for Persons with Dementia? A Pilot Study among Persons with Dementia and Their Informal Caregivers.

PubMed

Schmidhuber, Martina; Haeupler, Sandra; Marinova-Schmidt, Velislava; Frewer, Andreas; Kolominsky-Rabas, Peter L

2017-01-01

Advance directives could be an important instrument to support a person's will once he/she is not able to consent anymore - if composed competently. A survey was conducted to identify the level of knowledge concerning possibilities and limits of advance directives. The study was conducted as part of the Bavarian Dementia Survey (BayDem). Data were collected from January 2014 to December 2015 by structured face-to-face interviews. Study participants were persons with dementia and their informal caregivers ( n = 74). In total, 66% reported having written an advance directive. Concerning the participants' knowledge about possibilities and limitations of advance directives, a lack of knowledge was noted about the possibility to revoke an advance directive. Furthermore, 70% of informal caregivers and 56% of persons with dementia were not aware of the possibility to include dementia-specific terms in the advance directive. It is necessary to optimize structures for public information and education concerning the topic of advance directives for persons with dementia.

Some aerodynamic discoveries and related NACA/NASA research programs following World War 2

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1984-01-01

The World War 2 time period ushered in a new era in aeronautical research and development. The air conflict during the war highlighted the need of aircraft with agility, high speed, long range, large payload capability, and in addition, introduced a new concept in air warfare through the use of guided missiles. Following the war, the influx of foreign technology, primarily German, led to rapid advances in jet propulsion and speed, and a host of new problem areas associated with high-speed flight designs were revealed. The resolution of these problems led to a rash of new design concepts and many of the lessons learned, in principle, are still effective today. In addition to the technical lessons learned related to aircraft development programs, it might also be noted that some lessons involving the political and philosophical nature of aircraft development programs are worth attention.

Raising the AIQ of the Space Station

NASA Technical Reports Server (NTRS)

Lum, Henry; Heer, Ewald

1987-01-01

Expert systems and robotics technologies are to be significantly advanced during the Space Station program. Artificial intelligence systems (AI) on the Station will include 'scars', which will permit upgrading the AI capabilities as the Station evolves to autonomy. NASA-Ames is managing the development of the AI systems through a series of demonstrations, the first, controlling a single subsystem, to be performed in 1988. The capabilities being integrated into the first demonstration are described; however, machine learning and goal-driven natural language understanding will not reach a prototype stage until the mid-1990s. Steps which will be taken to endow the computer systems with the ability to move from heuristic reasoning to factual knowledge, i.e., learning from experience, are explored. It is noted that the development of Space Station expert systems depends on the development of experts in Station operations, which will not happen until the Station has been used extensively by crew members.

Actions Speak Louder Than Words: The U.N. Convention on the Rights of the Child and U.S. Pediatric Bioethicists.

PubMed

Lang, Kellie R; Lew, Cheryl D

2016-01-01

In exploring the relationship between "child rights" and "pediatric bioethics" and how these disciplines might provide mutual support in advancing the health and wellness of children around the world, our article responds to the questions of whether the U.N. Convention on the Rights of the Child (CRC) could be of any benefit in the United States, the only country that has not yet ratified this international treaty, and whether the CRC has any value for addressing clinical pediatric bioethics' questions. We describe the considerable influence that the United States had in developing significant components of the CRC, and we argue that the CRC may be useful for U.S. pediatric bioethicists as a tool to advance children's health policy. We note that ratification of the CRC does not equate with compliance or success. Lastly, we identify a distinction between the use of the term "best interests" by child rights advocates and its use by clinical pediatric bioethicists.

Achieving professional success in US government, academia, and industry: an EMGS commentary.

PubMed

Poirier, Miriam C; Schwartz, Jeffrey L; Aardema, Marilyn J

2014-08-01

One of the goals of the EMGS is to help members achieve professional success in the fields they have trained in. Today, there is greater competition for jobs in genetic toxicology, genomics, and basic research than ever before. In addition, job security and the ability to advance in one's career is challenging, regardless of whether one works in a regulatory, academic, or industry environment. At the EMGS Annual Meeting in Monterey, CA (September, 2013), the Women in EMGS Special Interest Group held a workshop to discuss strategies for achieving professional success. Presentations were given by three speakers, each representing a different employment environment: Government (Miriam C. Poirier), Academia (Jeffrey L. Schwartz), and Industry (Marilyn J. Aardema). Although some differences in factors or traits affecting success in the three employment sectors were noted by each of the speakers, common factors considered important for advancement included networking, seeking out mentors, and developing exceptional communication skills. © 2014 Wiley Periodicals, Inc.

Commonalities and distinctions among mechanisms of addiction to alcohol and other drugs

PubMed Central

Ozburn, Angela R.; Janowsky, Aaron J.; Crabbe, John C.

2015-01-01

Alcohol abuse is comorbid with abuse of many other drugs, some with similar pharmacology and others quite different. This leads to the hypothesis of an underlying, unitary dysfunctional neurobiological basis for substance abuse risk and consequences. In this review, we discuss commonalities and distinctions of addiction to alcohol and other drugs. We focus on recent advances in pre-clinical studies using rodent models of drug self-administration. While there are specific behavioral and molecular manifestations common to alcohol, psychostimulant, opioid, and nicotine dependence, attempts to propose a unifying theory of the addictions inevitably face details where distinctions are found among classes of drugs. For alcohol, versus other drugs of abuse, we discuss and compare advances in: 1) neurocircuitry important for the different stages of drug dependence; 2) transcriptomics and genetical genomics; and 3) enduring effects. We note in particular the contributions of behavioral genetics and animal models: discussions of progress specifically relevant to treatment development can be found in the accompanying review (Karoly et al, this issue). PMID:26431116

Chapter 1: Reliably Measuring the Performance of Emerging Photovoltaic Solar Cells

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rumbles, Garry; Reese, Matthew O; Marshall, Ashley

Determining the power conversion efficiency of photovoltaic solar cells, especially those from new, emerging areas of technology, is important if advances in performance are to be made. However, although precise measurements are important, it is the accuracy of these types of measurements that can cause issues. Accurate measurements not only promote the development of new technology platforms, but they also enable comparisons with established technologies and allow assessments of advancements within the same field. This chapter provides insights into how measurements can be made with reasonable accuracy using both the components of the measuring system and a good protocol tomore » acquire good data. The chapter discusses how to measure a calibrated lamp spectrum, determine a spectral mismatch factor, identify the correct reference cell and filter, define the illuminated active area, measure J-V curves to avoid any hysteresis effects, take note of sample degradation issues and avoid the temptation to artificially enhance efficiency data.« less

The Combat-Exclusion Policy for Military Women.

ERIC Educational Resources Information Center

Schneider, Dorothy; Schneider, Carl J.

1986-01-01

Reviews the history and meaning of the combat exclusion policy for United States servicewomen. Noting that combat duty is often essential to career advancement in the military, this article describes several cases of discrimination resulting from the effects of the combat exclusion. (JDH)

Aligning interprofessional education collaborative sub-competencies to a progression of learning.

PubMed

Patel Gunaldo, Tina; Brisolara, Kari Fitzmorris; Davis, Alison H; Moore, Robert

2017-05-01

In the United States, the Interprofessional Education Collaborative (IPEC) developed four core competencies for interprofessional collaborative practice. Even though the IPEC competencies and respective sub-competencies were not created in a hierarchal manner, one might reflect upon a logical progression of learning as well as learners accruing skills allowing them to master one level of learning and building on the aggregate of skills before advancing to the next level. The Louisiana State University Health-New Orleans Center for Interprofessional Education and Collaborative Practice (CIPECP) determined the need to align the sub-competencies with the level of behavioural expectations in order to simplify the process of developing an interprofessional education experience targeted to specific learning levels. In order to determine the most effective alignment, CIPECP discussions revolved around current programmatic expectations across the institution. Faculty recognised the need to align sub-competencies with student learning objectives. Simultaneously, a progression of learning existing within each of the four IPEC domains was noted. Ultimately, the faculty and staff team agreed upon categorising the sub-competencies in a hierarchical manner for the four domains into either a "basic, intermediate, or advanced" level of competency.

Where is the skepticism in animal metacognition?

PubMed Central

Crystal, Jonathon D.

2015-01-01

The comparative analysis of metacognition may answer fundamental questions about the evolution of cognition. Although a substantial amount of research has been directed toward this goal in the last two decades, the recent development of quantitative non-metacognition models has raised questions about the existence of metacognition in nonhumans. Kornell (2013) proposes that advances in animal metacognition may be made by following emerging trends in human metacognition research, namely that animal metacognition may take the form of drawing inferences from metacognitive cues without directly assessing the strength of memories directly. A problem with this approach is noted. Because the metacognitive status of certainty judgments in animals is at the center of the dispute in the field, demonstrations of the inferential view would not provide evidence that putative metacognitive cues are indeed based on metacognition. I argue that any preparation that claims to tap into metacognition needs to be tested against leading non-metacognition hypotheses such as Le Pelley's (2012) reinforcement-learning model. Progress in animal metacognition will come from the development of new assessment techniques that offer predictions contrary to non-metacognition hypotheses. Animal metacognition will advance by applying skepticism about methods and interpretation while letting the animals (and their data) settle the debate. PMID:24866006

Hyperspectral imaging of polymer banknotes for building and analysis of spectral library

NASA Astrophysics Data System (ADS)

Lim, Hoong-Ta; Murukeshan, Vadakke Matham

2017-11-01

The use of counterfeit banknotes increases crime rates and cripples the economy. New countermeasures are required to stop counterfeiters who use advancing technologies with criminal intent. Many countries started adopting polymer banknotes to replace paper notes, as polymer notes are more durable and have better quality. The research on authenticating such banknotes is of much interest to the forensic investigators. Hyperspectral imaging can be employed to build a spectral library of polymer notes, which can then be used for classification to authenticate these notes. This is however not widely reported and has become a research interest in forensic identification. This paper focuses on the use of hyperspectral imaging on polymer notes to build spectral libraries, using a pushbroom hyperspectral imager which has been previously reported. As an initial study, a spectral library will be built from three arbitrarily chosen regions of interest of five circulated genuine polymer notes. Principal component analysis is used for dimension reduction and to convert the information in the spectral library to principal components. A 99% confidence ellipse is formed around the cluster of principal component scores of each class and then used as classification criteria. The potential of the adopted methodology is demonstrated by the classification of the imaged regions as training samples.

Technological advances for studying human behavior

NASA Technical Reports Server (NTRS)

Roske-Hofstrand, Renate J.

1990-01-01

Technological advances for studying human behavior are noted in viewgraph form. It is asserted that performance-aiding systems are proliferating without a fundamental understanding of how they would interact with the humans who must control them. Two views of automation research, the hardware view and the human-centered view, are listed. Other viewgraphs give information on vital elements for human-centered research, a continuum of the research process, available technologies, new technologies for persistent problems, a sample research infrastructure, the need for metrics, and examples of data-link technology.

Annual Research Review: Growth connectomics – the organization and reorganization of brain networks during normal and abnormal development

PubMed Central

Vértes, Petra E; Bullmore, Edward T

2015-01-01

Background We first give a brief introduction to graph theoretical analysis and its application to the study of brain network topology or connectomics. Within this framework, we review the existing empirical data on developmental changes in brain network organization across a range of experimental modalities (including structural and functional MRI, diffusion tensor imaging, magnetoencephalography and electroencephalography in humans). Synthesis We discuss preliminary evidence and current hypotheses for how the emergence of network properties correlates with concomitant cognitive and behavioural changes associated with development. We highlight some of the technical and conceptual challenges to be addressed by future developments in this rapidly moving field. Given the parallels previously discovered between neural systems across species and over a range of spatial scales, we also review some recent advances in developmental network studies at the cellular scale. We highlight the opportunities presented by such studies and how they may complement neuroimaging in advancing our understanding of brain development. Finally, we note that many brain and mind disorders are thought to be neurodevelopmental in origin and that charting the trajectory of brain network changes associated with healthy development also sets the stage for understanding abnormal network development. Conclusions We therefore briefly review the clinical relevance of network metrics as potential diagnostic markers and some recent efforts in computational modelling of brain networks which might contribute to a more mechanistic understanding of neurodevelopmental disorders in future. PMID:25441756

Latest developments in on- and off-line inspection of bank notes during production

NASA Astrophysics Data System (ADS)

Brown, Stephen C.

2004-06-01

The inspection of bank notes is a highly labour intensive process where traditionally every note on every sheet is inspected manually. However with the advent of more and more sophisticated security features, both visible and invisible, and the requirement of cost reduction in the printing process, it is clear that automation is required. Machines for the automatic inspection of bank notes have been on the market for the past 10 to 12 years, but recent developments in technology have enabled a new generation of detectors and machines to be developed. This paper focuses on the latest developments in both the off-line and on-line inspection of bank notes covering not only the visible spectrum but also a new range of detectors for inspection some of the more common invisible features used as covert features in today's bank notes.

The California stem cell initiative: persuasion, politics, and public science.

PubMed

Adelson, Joel W; Weinberg, Joanna K

2010-03-01

The California Institute for Regenerative Medicine (CIRM) was created by a California ballot initiative to make stem cell research a constitutional right, in response to Bush administration restrictions on stem cell research. The initiative created a taxpayer-funded, multibillion-dollar institution, intended to advance public health by developing cures and treatments for diabetes, cancer, paralysis, and other conditions. The initiative has been highly controversial among stakeholders and watchdog groups concerned with organizational transparency, accountability, and the ethics of stem cell research. We interviewed major stakeholders-both supporters and opponents-and analyzed documents and meeting notes. We found that the CIRM has overcome start-up challenges, been selectively influenced by criticism, and adhered to its core mission.

The Age-ility Project (Phase 1): Structural and functional imaging and electrophysiological data repository.

PubMed

Karayanidis, Frini; Keuken, Max C; Wong, Aaron; Rennie, Jaime L; de Hollander, Gilles; Cooper, Patrick S; Ross Fulham, W; Lenroot, Rhoshel; Parsons, Mark; Phillips, Natalie; Michie, Patricia T; Forstmann, Birte U

2016-01-01

Our understanding of the complex interplay between structural and functional organisation of brain networks is being advanced by the development of novel multi-modal analyses approaches. The Age-ility Project (Phase 1) data repository offers open access to structural MRI, diffusion MRI, and resting-state fMRI scans, as well as resting-state EEG recorded from the same community participants (n=131, 15-35 y, 66 male). Raw imaging and electrophysiological data as well as essential demographics are made available via the NITRC website. All data have been reviewed for artifacts using a rigorous quality control protocol and detailed case notes are provided. Copyright © 2015. Published by Elsevier Inc.

The updated algorithm of the Energy Consumption Program (ECP): A computer model simulating heating and cooling energy loads in buildings

NASA Technical Reports Server (NTRS)

Lansing, F. L.; Strain, D. M.; Chai, V. W.; Higgins, S.

1979-01-01

The energy Comsumption Computer Program was developed to simulate building heating and cooling loads and compute thermal and electric energy consumption and cost. This article reports on the new additional algorithms and modifications made in an effort to widen the areas of application. The program structure was rewritten accordingly to refine and advance the building model and to further reduce the processing time and cost. The program is noted for its very low cost and ease of use compared to other available codes. The accuracy of computations is not sacrificed however, since the results are expected to lie within + or - 10% of actual energy meter readings.

Infectious Bronchitis Virus Variants: Molecular Analysis and Pathogenicity Investigation

PubMed Central

Lin, Shu-Yi

2017-01-01

Infectious bronchitis virus (IBV) variants constantly emerge and pose economic threats to poultry farms worldwide. Numerous studies on the molecular and pathogenic characterization of IBV variants have been performed between 2007 and 2017, which we have reviewed herein. We noted that viral genetic mutations and recombination events commonly gave rise to distinct IBV genotypes, serotypes and pathotypes. In addition to characterizing the S1 genes, full viral genomic sequencing, comprehensive antigenicity, and pathogenicity studies on emerging variants have advanced our understanding of IBV infections, which is valuable for developing countermeasures against IBV field outbreaks. This review of IBV variants provides practical value for understanding their phylogenetic relationships and epidemiology from both regional and worldwide viewpoints. PMID:28937583

A Brief History of Limb Lengthening.

PubMed

Birch, John G

2017-09-01

In the last 35 years, orthopaedic surgeons have witnessed 3 major advances in the technique of limb lengthening: "distraction osteogenesis" facilitated by Gavriil Ilizarov method and infinitely-adaptable circular fixator with fine-wire bone fragment fixation; the introduction of the "6-strut" computer program-assisted circular fixators to effect complex deformity correction simultaneously; and the development of motorized intramedullary lengthening nails. However, the principles and associated complications of these techniques are on the basis of observations by Codivilla, Putti, and Abbott from as much as 110 years ago. This review notes the contribution of these pioneers in limb lengthening, and the contribution of Thor Heyerdahl principles of tolerance and diversity to the dissemination of Ilizarov principles to the Western world.

Predictive global trends in the incidence and mortality of pancreatic cancer based on geographic location, socio-economic status, and demographic shift.

PubMed

Are, Chandrakanth; Chowdhury, Sanjib; Ahmad, Humera; Ravipati, Advaitaa; Song, Tianqiang; Shrikandhe, Shailesh; Smith, Lynette

2016-11-01

Pancreatic Cancer (PC) is a lethal malignancy that accounts for about 4% of cancer-related deaths worldwide. The aim of this study is to describe the influence of geography (based on WHO regions), socio-economic development (based on Human Development Index [HDI]) and demographic shift on the temporal trends in global incidence and mortality of PC. Data (2012-2030) relating to the incidence, mortality of PC and demographic shifts based on WHO regions and HDI areas were extracted from GLOBOCAN 2012. Linear regression was used to evaluate trends in total incidence and mortality. We noted a definite association between PC and higher socio-economic status. Advanced age (age ≥65) contributed to the rising burden in all socio-economic regions of the world except in the Low Human Development (LHD) countries where the disease predominantly affected population <65 years of age. The global burden of PC is expected to rise significantly over the next few decades regardless of geographic location, socio-economic development, age and gender. Advance knowledge of this data can help formulate strategies to specifically target countries and populations that promote public health policy to tackle this lethal disease on the global stage. J. Surg. Oncol. 2016;114:736-742. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Advances in simultaneous atmospheric profile and cloud parameter regression based retrieval from high-spectral resolution radiance measurements

NASA Astrophysics Data System (ADS)

Weisz, Elisabeth; Smith, William L.; Smith, Nadia

2013-06-01

The dual-regression (DR) method retrieves information about the Earth surface and vertical atmospheric conditions from measurements made by any high-spectral resolution infrared sounder in space. The retrieved information includes temperature and atmospheric gases (such as water vapor, ozone, and carbon species) as well as surface and cloud top parameters. The algorithm was designed to produce a high-quality product with low latency and has been demonstrated to yield accurate results in real-time environments. The speed of the retrieval is achieved through linear regression, while accuracy is achieved through a series of classification schemes and decision-making steps. These steps are necessary to account for the nonlinearity of hyperspectral retrievals. In this work, we detail the key steps that have been developed in the DR method to advance accuracy in the retrieval of nonlinear parameters, specifically cloud top pressure. The steps and their impact on retrieval results are discussed in-depth and illustrated through relevant case studies. In addition to discussing and demonstrating advances made in addressing nonlinearity in a linear geophysical retrieval method, advances toward multi-instrument geophysical analysis by applying the DR to three different operational sounders in polar orbit are also noted. For any area on the globe, the DR method achieves consistent accuracy and precision, making it potentially very valuable to both the meteorological and environmental user communities.

Advanced Texas Studies: Curriculum Guide.

ERIC Educational Resources Information Center

Harlandale Independent School District, San Antonio, TX. Career Education Center.

The guide is arranged in vertical columns relating curriculum concepts in Texas studies to curriculum performance objectives, career concepts and career performance objectives, suggested teaching methods, and audio-visual and resource materials. Career information is included on 24 related occupations. Space is provided for teachers' notes which…

Missing Mechanism Information

ERIC Educational Resources Information Center

Tryon, Warren W.

2009-01-01

The first recommendation Kazdin made for advancing the psychotherapy research knowledge base, improving patient care, and reducing the gulf between research and practice was to study the mechanisms of therapeutic change. He noted, "The study of mechanisms of change has received the least attention even though understanding mechanisms may well be…

Computer Simulation and ESL Reading.

ERIC Educational Resources Information Center

Wu, Mary A.

It is noted that although two approaches to second language instruction--the communicative approach emphasizing genuine language use and computer assisted instruction--have come together in the form of some lower level reading instruction materials for English as a second language (ESL), advanced level ESL reading materials using computer…

Advancing Reflectrometry

DTIC Science & Technology

2013-05-21

13. SUPPLEMENTARY NOTES 14. ABSTRACT Reflectometry , a microwave remote sensing technique to extract geophysical data from scattered satellite...transmissions, was first demonstrated using Global Navigation Satellite System (GNSS) reflections. Recently, reflectometry has been extended to digital...potential missions. a 15. SUBJECT TERMS Reflectometry , Ocean Winds, Global Navigation Satellites, Communication Satellites 16. SECURITY

Two Linguists on Freshman English: Pressure from Below.

ERIC Educational Resources Information Center

Francis, W. Nelson

1964-01-01

The importance of improving English instructors' attitudes toward three broadly classified forms of language expression is examined. The author notes an increased interest in languages among college freshmen and defines the differences between (1) artistic, (2) playful, and (3) intellectual expression. Pressure resulting from advanced teaching…

Technology & Stress: Are They Inseparable?

ERIC Educational Resources Information Center

Mather, Becky

1998-01-01

Describes how technology changes the nature of the school media specialist's job, and discusses staff and equipment sources of techno-stress. Notes the importance of anticipating problem areas and planning to deal with them in advance. Presents strategies for minimizing the amount of frustration/stress associated with technology. (AEF)

An Integrated Library System: Preliminary Considerations.

ERIC Educational Resources Information Center

Neroda, Edward

Noting difficulties experienced by small to medium sized colleges in acquiring integrated library computer systems, this position paper outlines issues related to the subject with the intention of increasing familiarity and interest in integrated library systems. The report includes: a brief review of technological advances as they relate to…

Motor carrier case study evaluation report : appendix C, Vol. 2 : case study field notes, the Crescent Evaluation

DOT National Transportation Integrated Search

1994-02-01

The Crescent Project element of the HELP Program is a bi-national multi-jurisdictional : cooperative research and demonstration initiative involving the public and private sectors in an : application of advanced technologies for the creation of an in...

Merchants of Death: Media Violence and American Empire.

ERIC Educational Resources Information Center

Trend, David

2003-01-01

Research has done little to advance understanding of who accesses the violent imagery in popular culture. The narrow perspective provided by mass-produced media violence must be broadened by critical viewpoints that provide information people need to participate in the democratic process. (Contains 85 reference notes.) (SK)

Technological Effects on Interpersonal Communication: A Classroom Activity.

ERIC Educational Resources Information Center

Vandehaar, Debb

Noting that few scholars have examined specifically how technology is affecting basic communication processes, students in interpersonal, small group, and advanced presentational forms classes studied the systems model of interpersonal communication. The systems model described by P. Emmert and W.C. Donaghy includes the following components:…

76 FR 77268 - Sunshine Act; Notice of Agency Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... Regulations, Corporate Credit Unions. 2. NCUA Strategic Plan 2011-2014. 3. NCUA Annual Performance Budget 2012... Participations. 8. Advance Notice of Proposed Rulemaking, Part 741 of NCUA's Rules and Regulations, Maintaining Access to Emergency Liquidity. 9. 2012 Budget for NCUA Guaranteed Note Securities Management and...

Globalization and Women in Southeast Asian Higher Education Management.

ERIC Educational Resources Information Center

Luke, Carmen

2002-01-01

This case study of Southeast Asian women in higher education management investigates culture-specific dimensions of "glass ceiling" impediments to career advancement in higher education. Respondents note that despite considerable training and expertise, Asian values and ideologies demand enactment of a construct of Asian femininity that…

Issues and Challenges Facing the Minority Woman Dentist.

ERIC Educational Resources Information Center

Sinkford, Jeanne C.

1992-01-01

The status of minority women dentists is reviewed, and initiatives to improve it are noted. Issues and challenges for African-American female dentists are outlined, including negative racial/gender stereotypes, lack of advancement opportunities, difficulties in starting practices and securing professional and social support systems, lack of…

Ecology and Equity: Toward the Rational Reenchantment of Schools and Society.

ERIC Educational Resources Information Center

Kurth-Schai, Ruthanne

1992-01-01

Discusses the advancement of social and environmental justice through schooling, noting philosophical barriers to equity. The article recommends a moral and conceptual vision where differences causing exploitation and alienation change into relationships fostering equity and reciprocity. Rational reenchantment can promote social and environmental…

48 CFR 23.704 - Electronic product environmental assessment tool.

Code of Federal Regulations, 2014 CFR

2014-10-01

... REGULATION SOCIOECONOMIC PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES... Electrical and Electronics Engineers, Inc., on March 5, 2010; October 19, 2012, and October 19, 2012.... 272 note), the “National Technology Transfer and Advancement Act of 1995,” (see 11.102(c)); (iii...

12 CFR 204.8 - International banking facilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... depositor or of its affiliates located outside the United States; and (C) That is maintained under an... promissory note, security, acknowledgment of advance, due bill, repurchase agreement, or any other form of... writing whenever a deposit or credit relationship is first established with the IBF. (c) Exemption from...

12 CFR 204.8 - International banking facilities.

Code of Federal Regulations, 2011 CFR

2011-01-01

... depositor or of its affiliates located outside the United States; and (C) That is maintained under an... promissory note, security, acknowledgment of advance, due bill, repurchase agreement, or any other form of... writing whenever a deposit or credit relationship is first established with the IBF. (c) Exemption from...

12 CFR 204.8 - International banking facilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... depositor or of its affiliates located outside the United States; and (C) That is maintained under an... promissory note, security, acknowledgment of advance, due bill, repurchase agreement, or any other form of... writing whenever a deposit or credit relationship is first established with the IBF. (c) Exemption from...

Aircraft concepts for advanced short haul systems

NASA Technical Reports Server (NTRS)

Galloway, T. L.

1975-01-01

The results of recent NASA-sponsored high-density and medium-density short-haul (less than 500 miles) air transportation systems studies are summarized. Trends in vehicle characteristics, in particular of RTOL and STOL concepts, are noted, and their economic suitability and impact on the community are examined.

Social Network Map: Some Further Refinements on Administration.

ERIC Educational Resources Information Center

Tracy, Elizabeth M.; Abell, Neil

1994-01-01

Notes that social network mapping techniques have been advanced as means of assessing social and environmental resources. Addresses issue of convergent construct validity, correlations among dimensions of perceived social support as measured by social network data with other standardized social support instruments. Findings confirm that structural…

Moisès Broggi i Vallès (1908-2012): Military surgeon and Catalan humanitarian.

PubMed

Derby, Mark; Jorge, David

2016-02-01

Catalan surgeon Moisès Broggi entered medical practice in 1931 as Spain was modernizing rapidly. Five years later, however, an attempted military coup sparked a nationwide civil war. Broggi offered his services to the embattled Republic and joined the Medical Service of the International Brigades. He served alongside colleagues from many countries, helping to develop advances in military medicine and especially trauma surgery. Broggi chose to remain working in Barcelona as Franco's Nationalist forces entered the city, in spite of the risk of reprisal he faced as a former officer of the International Brigades. Although forced from his leading position in the public health service, he developed a distinguished private practice. In the year of Franco's death he became President of Barcelona's Royal Academy of Medicine and he received many other honours. Just months before his death at the remarkable age of 104, Dr Moisès Broggi continued to discuss and write about the concerns that had directed the course of his life--advances in medical science and the intellectual and political repression that had hindered delivery of those advances. In an article titled Exile and Silence he noted the groundbreaking work carried out under the auspices of the prestigious scientific institutions founded during Spain's Second Republic and the subsequent dark decades of exile suffered by many of their prominent scientists, some of them his close friends. © The Author(s) 2014.

NOTES performed using multiple ports of entry: Current experience and potential implications for urologic applications.

PubMed

Lima, Estevao; Rolanda, Carla; Correia-Pinto, Jorge

2009-05-01

An isolated transgastric port raises serious limitations in performing natural orifice translumenal endoscopic surgery (NOTES) complex procedures in the urology field. In an attempt to overcome these limitations, several solutions has been advanced, such as the hybrid approach (adding a single abdominal port access) or the pure NOTES combined approach (joining multiple natural orifice ports). To review the current state of experimental and clinical results of multiple ports in NOTES, a literature search of PubMed was performed, seeking publications from January 2002 to 2008 on NOTES. In addition, we looked at pertinent abstracts of annual meetings of the American Urological Association, the European Association of Urology, and the World Congress of Endourology from 2007. Multiple ports of entry seem to be necessary, mainly for moderately complex procedures. Thus, we could find studies using the hybrid approach (combination of transgastric or transvaginal access with a single transabdominal port), or using the pure NOTES combined approach (transgastric and transvesical, transvaginal and transcolonic, or transgastric and transvaginal). There is still limited experience in humans using these approaches, and no comparative studies exist to date. It is predictable that for moderately complex procedures, we will need multiple ports, so the transvaginal-transabdominal (hybrid) approach is the most appealing, whereas in a pure NOTES perspective, the transgastric-transvesical approach seems to be the preferred approach. We are waiting for new equipment and instruments that are more appropriate for these novel techniques.

Yoga as palliation in women with advanced cancer: a pilot study.

PubMed

Carr, Tracey; Quinlan, Elizabeth; Robertson, Susan; Duggleby, Wendy; Thomas, Roanne; Holtslander, Lorraine

2016-03-01

The purpose of this pilot study was to investigate the palliative potential of home-based yoga sessions provided to women with advanced cancer. Personalised 45-minute yoga sessions were offered to three women with advanced cancer by an experienced yoga teacher. Each woman took part in a one-to-one interview after the completion of the yoga programme and was asked to describe her experiences of the programme's impact. The personalised nature of the yoga sessions resulted in similar positive physical and psychosocial effects comparable to those demonstrated in other studies with cancer patients. Participants described physical, mental, and emotional benefits as well as the alleviation of illness impacts. The enhancement of mind-body and body-spirit connections were also noted. Personalised home-based yoga programmes for people with advanced cancer may produce similar benefits, including palliation, as those institutionally-based programmes for people with non-advanced cancer.

Advance Directives in Some Western European Countries: A Legal and Ethical Comparison between Spain, France, England, and Germany.

PubMed

Veshi, Denard; Neitzke, Gerald

2015-09-01

We have studied national laws on advance directives in various Western European countries: Romance-speaking countries (Italy, France, Portugal, and Spain), English-speaking countries (Ireland and the United Kingdom), and German-speaking countries (Austria, Germany, and Switzerland). We distinguish two potentially complementary types of advance medical declaration: the 'living will' and the nomination of a legal proxy. After examining the similarities and differences between countries, we analyse in detail the legislation of four countries (Spain, France, England, and Germany), since the other countries in this survey have similar legal principles and/or a similar political approach. In conclusion, we note that in all the countries examined, advance directives have been seen as an instrument to enable the patient's right to self-determination. Notwithstanding, in Romance-speaking countries, the involvement of physicians in the end-of-life process and risks arising from the execution of advance directives were also considered.

Advance Directives as Support of Autonomy for Persons with Dementia? A Pilot Study among Persons with Dementia and Their Informal Caregivers

PubMed Central

Schmidhuber, Martina; Haeupler, Sandra; Marinova-Schmidt, Velislava; Frewer, Andreas; Kolominsky-Rabas, Peter L.

2017-01-01

Background Advance directives could be an important instrument to support a person's will once he/she is not able to consent anymore – if composed competently. A survey was conducted to identify the level of knowledge concerning possibilities and limits of advance directives. Methods The study was conducted as part of the Bavarian Dementia Survey (BayDem). Data were collected from January 2014 to December 2015 by structured face-to-face interviews. Study participants were persons with dementia and their informal caregivers (n = 74). Results In total, 66% reported having written an advance directive. Concerning the participants' knowledge about possibilities and limitations of advance directives, a lack of knowledge was noted about the possibility to revoke an advance directive. Furthermore, 70% of informal caregivers and 56% of persons with dementia were not aware of the possibility to include dementia-specific terms in the advance directive. Conclusion It is necessary to optimize structures for public information and education concerning the topic of advance directives for persons with dementia. PMID:29118785

Predicting Radiation Esophagitis Using 18F-FDG PET During Chemoradiotherapy for Locally Advanced Non-Small Cell Lung Cancer.

PubMed

Mehmood, Qurrat; Sun, Alexander; Becker, Nathan; Higgins, Jane; Marshall, Andrea; Le, Lisa W; Vines, Douglass C; McCloskey, Paula; Ford, Victoria; Clarke, Katy; Yap, Mei; Bezjak, Andrea; Bissonnette, Jean-Pierre

2016-02-01

Treatment of locally advanced non-small cell lung cancer with chemoradiotherapy (CRT) is limited by development of toxicity in normal tissue, including radiation esophagitis (RE). Increasingly, (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is being used for adaptive planning. Our aim was to assess changes in esophageal FDG uptake during CRT and relate the changes to the onset and severity of RE. This prospective study in patients with stage II-III non-small cell lung cancer involved serial four-dimensional computed tomography and PET scans during CRT (60-74Gy). RE was recorded weekly using the Common Terminology Criteria for Adverse Events (v4.0), and imaging was performed at weeks 0, 2, 4, and 7. Changes in the esophagus's peak standard uptake value (SUVpeak) were analyzed for each time point and correlated with grade of RE using the Wilcoxon rank-sum test. The volume of esophagus receiving 50 Gy (V50) and volume of esophagus receiving 60 Gy (V60) were correlated with the development of RE, and the C-statistic (area under the curve [AUC]) was calculated to measure predictivity of grade 3 RE. RE developed in 20 of 27 patients (74%), with grade 3 reached in 6 (22%). A significant percentage increase in SUVpeak in the patients with RE was noted at week 4 (p = 0.01) and week 7 (p = 0.03). For grade 3 RE, a significant percentage increase in SUVpeak was noted at week 2 (p = 0.01) and week 7 (p = 0.03) compared with that for less than grade 3 RE. Median V50 (46.3%) and V60 (33.4%) were significantly higher in patients with RE (p = 0.04). The AUC measurements suggested that the percentage change in SUVpeak at week 2 (AUC = 0.69) and V50 (AUC = 0.67) and V60 (AUC = 0.66) were similarly predictive of grade 3 RE. Serial FDG-PET images during CRT show significant increases in SUVpeak for patients in whom RE develops. The changes at week 2 may predict those at risk for the development of grade 3 RE and may be informative for adaptive planning and early intervention. Copyright © 2015 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

Modes of Power in Technical and Professional Visuals.

ERIC Educational Resources Information Center

Barton, Ben F.; Barton, Marthalee S.

1993-01-01

Treats visuals as sites of power inscription. Advances a Foucauldian design model based on the Panoptican--Jeremy Bentham's architectural figure for empowerment based on bimodal surveillance. Notes that numerous examples serve in demonstrating that maximum effectiveness results when visuals foster simultaneous viewing in the two panoptic modes,…

Teaching English and History through Historical Fiction.

ERIC Educational Resources Information Center

Hicks, Alun; Martin, Dave

1997-01-01

Explores the appeal of historical fiction for young readers and describes its place within any school curriculum. Describes a project in Dorset Middle Schools which used historical fiction to teach medieval history and English. Notes that students' historical thinking was improved, their knowledge of medieval world advanced, and their writing was…

12 CFR 201.3 - Extensions of credit generally.

Code of Federal Regulations, 2010 CFR

2010-01-01

... institution must be secured to the satisfaction of the Federal Reserve Bank that makes the advance... securities, and business, consumer, and other customer notes. (3) If a Federal Reserve Bank concludes that a... specific to asset-backed securities in the particular TALF asset sector (as defined in the TALF haircut...

77 FR 28336 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Offset Lithographic...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-14

... Technology Transfer and Advancement Act of 1995 (15 U.S.C. 272 note) because application of those... Technology (RACT) for sources covered by EPA's Control Techniques Guidelines (CTG) for offset lithographic..., unless the comment includes information claimed to be Confidential Business Information (CBI) or other...

Advancing Breakthrough Therapies for Patients Act of 2012

THOMAS, 112th Congress

Sen. Bennet, Michael F. [D-CO

2012-03-26

Senate - 03/26/2012 Read twice and referred to the Committee on Health, Education, Labor, and Pensions. (All Actions) Notes: For further action, see S.3187, which became Public Law 112-144 on 7/9/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Techniques for Presenting the Short Story in the Advanced ESL Classroom.

ERIC Educational Resources Information Center

Williamson, Julia

1989-01-01

Suggestions are made for introducing students, especially those at the college level, to American short stories. An anthology of stories, chronologically presented, is noted as a useful text. Three approaches for presentation include historical sequencing, grouping according to salient elements of fiction, and grouping by theme. Pre-reading…

ADVANCED INSULATIONS FOR REFRIGERATOR/FREEZERS: THE POTENTIAL FOR NEW SHELL DESIGNS INCORPORATING POLYMER BARRIER CONSTRUCTION

EPA Science Inventory

The report examines domestic refrigerator/freezer (R/F) design alternatives which may offer greater increase in thermal performance than is possible with panel/foam composites. (NOTE: Current efforts to design and build R/Fs with high performance insulation technology are directe...

Examining the Feminisation of Migration Concept for Adult Education

ERIC Educational Resources Information Center

Cuban, Sondra

2010-01-01

The feminisation of migration is absent in policy and programmatic discourses on adult education in the USA and England. This paper uses an intersectional framework and feminist transnational methodology to probe this concept and its implications for women migrants and their education and advancement. (Contains 6 notes.)

Data security101: avoiding the list.

PubMed

Perna, Gabriel

2012-01-01

Thanks to the rampant digitization of healthcare data, breaches have become commonplace in an industry that lacks advanced security practices. In this industry-wide report, those who have dealt with breaches implore others to shore up internal security practices and be transparent. As one CIO keenly notes, "we're all in this together."

Hospital Bioethics: A Beginning Knowledge Base for the Neonatal Social Worker.

ERIC Educational Resources Information Center

Silverman, Ed

1992-01-01

Notes that life-saving advances in medicine have created difficult ethical and legal dilemmas for health care professionals. Presents beginning knowledge base for bioethical practice, especially in hospital neonatal units. Outlines key elements of bioethical decision making and examines potential social work role from clinical and organizational…

Education Calls for a New Philosophy.

ERIC Educational Resources Information Center

Scheidlinger, Zygmunt

1999-01-01

Highlights changes brought on by computers and technological advancement and notes that only those with a vision of the future can direct and participate in the evolution of education. Suggests that virtual reality, simulation, animation and other computer-based features will render traditional class learning futile and that computerized education…

Successful AP Music Theory Instruction: A Case Study

ERIC Educational Resources Information Center

Buonviri, Nathan O.

2018-01-01

The purpose of this case study was to examine the instructional approach of a highly successful Advanced Placement Music Theory teacher. I visited the participant's class twice a week for 14 weeks, taking field notes, conducting interviews, and collecting instructional artifacts. Analysis of qualitative data revealed three main themes: classroom…

Teachable Anthologies of Short Fiction for Developmental Students.

ERIC Educational Resources Information Center

Ngovo, Bernard L.

2002-01-01

Explains the rationale for including short fiction in the curricula for two college developmental reading classes and describes the features of the anthologies used. Suggests the use of the middle and the advanced levels of "Best Short Stories" published by Jamestown Publishers. Notes that these anthologies contain features that make…

7 CFR 762.146 - Other servicing procedures.

Code of Federal Regulations, 2010 CFR

2010-01-01

... funds to be advanced are for authorized operating loan purposes; (ii) The financial benefit to the... refer to the original note. (5) The lender will inform the Agency of the rate change. (e) Consolidation... borrower must project a feasible plan after the consolidation. See § 762.102(b) for definition of feasible...

Bayesian Authentication: Quantifying Security of the Hancke-Kuhn Protocol

DTIC Science & Technology

2010-01-01

Conference on Advances in Cryptology, pages 169–177, London, UK, 1991. Springer-Verlag. [6] Stefan Brands and David Chaum . Distance-bounding protocols. In...Lecture Notes in Computer Science, pages 371–388. Springer, 2004. [30] Patrick Schaller, Benedikt Schmidt, David Basin, and Srdjan Capkun. Modeling and

7 CFR 3555.304 - Special servicing options.

Code of Federal Regulations, 2014 CFR

2014-01-01

... consider a mortgage recovery advance under this section in addition to the extended-term loan modification... required for taxes and insurance. (6) The following terms apply to the repayment of mortgage recovery... does not change the terms of the loan note guarantee. (4) Special servicing options shall be used in...

By All Means, Study the Founders: Notes from the Democratic Left

ERIC Educational Resources Information Center

Street, Paul

2003-01-01

A thesis concocted by right-wing ideological watchdogs and advanced with elevated urgency in the wake September 11, 2001, claims that America's college and university students are hostage to a leftist, "moral-relativist" and multiculturalist professoriat. To restore right-thinking to college campuses, the argument continues, academic…

Advances in Environmental Science and Technology, Volume Two.

ERIC Educational Resources Information Center

Pitts, James N., Jr., Ed.; Metcalf, Robert L., Ed.

The aim of this volume is to help delineate and solve the multitude of environmental problems our technology has created. Representing a diversity of notable approaches to crucial environmental issues, it features eight self-contained chapters by noted scientists. Topics range from broad considerations of air pollution and specific techniques for…

Rehabilitation of the Ankle after Acute Sprain or Chronic Instability.

ERIC Educational Resources Information Center

Mattacola, Carl G.; Dwyer, Maureen K.

2002-01-01

Outlines rehabilitation concepts applicable to acute and chronic ankle injury, providing evidence for current techniques used in ankle rehabilitation and describing a functional rehabilitation program that progresses from basic to advanced, while taking into account empirical data from the literature and clinical practice. The article notes that…

Scholarly Information Centers in ARL Libraries. SPEC Kit 175.

ERIC Educational Resources Information Center

Allen, Nancy, Comp.; Godden, Irene, Comp.

Noting that the rapid evolution of telecommunications technology, the relentless advancement of computing capabilities, and the seemingly endless proliferation of electronic data have had a profound impact on research libraries, this Systems and Procedures Exchange Center (SPEC) kit explores the extent to which these technologies have come…

Advanced Research into Imaging of Moving Targets

DTIC Science & Technology

2009-12-01

Postgraduate School Monterey, CA 93943-5000 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES...N/A 10. SPONSORING/ MONITORING AGENCY REPORT NUMBER 11. SUPPLEMENTARY NOTES The views expressed in this thesis are those of the author and do...19 A. SYNTHETIC APERTURE IMAGING .......................................................19 B. RADON

77 FR 30053 - Repair Stations

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-21

... was revoked as described in Sec. 145.1051(e). The FAA notes that denial is not automatic. If the... practices, or advances in aircraft technology. These changes would modernize the regulations to keep pace..., Washington, DC 20590-0001. Hand Delivery or Courier: Take comments to Docket Operations in Room W12-140 of...

Extracellular matrix glycation and receptor for advanced glycation end-products activation: a missing piece in the puzzle of the association between diabetes and cancer.

PubMed

Rojas, Armando; Añazco, Carolina; González, Ileana; Araya, Paulina

2018-04-05

A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. Cancer cells are surrounded by a complex milieu, also known as tumor microenvironment, which contributes to the development and metastasis of tumors. Of note, one of the major components of this niche is the extracellular matrix (ECM), which becomes highly disorganized during neoplastic progression, thereby stimulating cancer cell transformation, growth and spread. One of the consequences of chronic hyperglycemia, the most frequently observed sign of diabetes and the etiological source of diabetes complications, is the irreversible glycation and oxidation of proteins and lipids leading to the formation of the advanced glycation end-products (AGEs). These compounds may covalently crosslink and biochemically modify structure and functions of many proteins, and AGEs accumulation is particularly high in long-living proteins with low biological turnover, features that are shared by most, if not all, ECM proteins. AGEs-modified proteins are recognized by AGE-binding proteins, and thus glycated ECM components have the potential to trigger Receptor for advanced glycation end-products-dependent mechanisms. The biological consequence of receptor for advanced glycation end-products activation mechanisms seems to be connected, in different ways, to drive some hallmarks of cancer onset and tumor growth. The present review intends to highlight the potential impact of ECM glycation on tumor progression by triggering receptor for advanced glycation end-products-mediated mechanisms.

Classical Electrodynamics: Problems with solutions; Problems with solutions

NASA Astrophysics Data System (ADS)

Likharev, Konstantin K.

2018-06-01

l Advanced Physics is a series comprising four parts: Classical Mechanics, Classical Electrodynamics, Quantum Mechanics and Statistical Mechanics. Each part consists of two volumes, Lecture notes and Problems with solutions, further supplemented by an additional collection of test problems and solutions available to qualifying university instructors. This volume, Classical Electrodynamics: Lecture notes is intended to be the basis for a two-semester graduate-level course on electricity and magnetism, including not only the interaction and dynamics charged point particles, but also properties of dielectric, conducting, and magnetic media. The course also covers special relativity, including its kinematics and particle-dynamics aspects, and electromagnetic radiation by relativistic particles.

Some more similarities between Peirce and Skinner

PubMed Central

Moxley, Roy A.

2002-01-01

C. S. Peirce is noted for pioneering a variety of views, and the case is made here for the similarities and parallels between his views and B. F. Skinner's radical behaviorism. In addition to parallels previously noted, these similarities include an advancement of experimental science, a behavioral psychology, a shift from nominalism to realism, an opposition to positivism, a selectionist account for strengthening behavior, the importance of a community of selves, a recursive approach to method, and the probabilistic nature of truth. Questions are raised as to the extent to which Skinner's radical behaviorism, as distinguished from his S-R positivism, may be seen as an extension of Peirce's pragmatism. PMID:22478387

The leadership continuum: a framework for organizational and individual assessment relative to the advancement of women physicians and scientists.

PubMed

Morahan, Page S; Rosen, Sally E; Richman, Rosalyn C; Gleason, Katharine A

2011-03-01

In the United States, women have attained near gender equity at the entry stages in academic medicine; however, progress has been much slower at senior leadership levels. The paucity of women leaders inhibits the ability of academic medicine to adequately meet the needs of an increasingly diverse body of students, faculty, staff, and patients. Research indicates that until a critical mass of women with sustained success as leaders is achieved, it is unlikely that this deficit will be corrected. To promote the attainment of a critical mass of women leaders, the authors integrate two approaches to advancing women--the concept of a leadership continuum and a framework of practical approaches for moving toward gender equity at all ranks. An institutional guide is presented that can be used to promote dialogue about gender equity, noting areas of success and opportunities for additional improvement as well as an assessment of progress. A corresponding checklist has been developed that women faculty can use as a reflection guide for their career planning and to assess their position and progress along the leadership continuum. Proactive, ongoing use of these frameworks can promote reflective dialogue and provide direction and accountability for institutions working to advance women into leadership positions.

Thinking Strategically to Record Notes in Content Classes

ERIC Educational Resources Information Center

Boyle, Joseph R.

2011-01-01

Although teachers today use a variety of teaching methods in content-area classrooms, lecture learning and note-taking still comprise a considerable portion of time in these classes. Unfortunately, most students are poor note-takers, typically recording only about one quarter of lecture notes. Strategic note-taking was developed to assist students…

Carbon dioxide removal and the futures market

NASA Astrophysics Data System (ADS)

Coffman, D.'Maris; Lockley, Andrew

2017-01-01

Futures contracts are exchange-traded financial instruments that enable parties to fix a price in advance, for later performance on a contract. Forward contracts also entail future settlement, but they are traded directly between two parties. Futures and forwards are used in commodities trading, as producers seek financial security when planning production. We discuss the potential use of futures contracts in Carbon Dioxide Removal (CDR) markets; concluding that they have one principal advantage (near-term price security to current polluters), and one principal disadvantage (a combination of high price volatility and high trade volume means contracts issued by the private sector may cause systemic economic risk). Accordingly, we note the potential for the development of futures markets in CDR, but urge caution about the prospects for market failure. In particular, we consider the use of regulated markets: to ensure contracts are more reliable, and that moral hazard is minimised. While regulation offers increased assurances, we identify major insufficiencies with this approach—finding it generally inadequate. In conclusion, we suggest that only governments can realistically support long-term CDR futures markets. We note existing long-term CDR plans by governments, and suggest the use of state-backed futures for supporting these assurances.

Facility's employment practices reflect affirmative action commitment.

PubMed

Glaser, J W; Madden, M J

1984-04-01

The U.S. bishops' statements on racism over the last 40 years have addressed the structural as well as the personal aspects of racial discrimination. They have noted its persistence, described it as a moral and religious problem, and called for aggressive action among Catholics to combat it. "Meaningful equality" for blacks, however, remains a distant dream, the U.S. Supreme Court noted in a recent case involving institutional discrimination, because of the basically disadvantaged position into which blacks are born. As statistics on health, education, work, and standard of living illustrate, the socioeconomic opportunities available to blacks are markedly lower than those available to white Americans. Despite these odds, efforts to improve blacks' chances of contributing to society--through affirmative action programs--have achieved striking results in industry. Hospitals, as major workplaces, likewise should focus greater attention on developing and extending minority employment and advancement programs. Catholic health care facilities especially should evaluate their commitments to affirmative action. Increased efforts to eliminate discrimination in all aspects of a hospital's relationships with the business community as well as with its own employees will cause them to be recognized as symbols of justice not only in the workplace but also in society.

Computational fluid dynamics - The coming revolution

NASA Technical Reports Server (NTRS)

Graves, R. A., Jr.

1982-01-01

The development of aerodynamic theory is traced from the days of Aristotle to the present, with the next stage in computational fluid dynamics dependent on superspeed computers for flow calculations. Additional attention is given to the history of numerical methods inherent in writing computer codes applicable to viscous and inviscid analyses for complex configurations. The advent of the superconducting Josephson junction is noted to place configurational demands on computer design to avoid limitations imposed by the speed of light, and a Japanese projection of a computer capable of several hundred billion operations/sec is mentioned. The NASA Numerical Aerodynamic Simulator is described, showing capabilities of a billion operations/sec with a memory of 240 million words using existing technology. Near-term advances in fluid dynamics are discussed.

The California Stem Cell Initiative: Persuasion, Politics, and Public Science

PubMed Central

Weinberg, Joanna K.

2010-01-01

The California Institute for Regenerative Medicine (CIRM) was created by a California ballot initiative to make stem cell research a constitutional right, in response to Bush administration restrictions on stem cell research. The initiative created a taxpayer-funded, multibillion-dollar institution, intended to advance public health by developing cures and treatments for diabetes, cancer, paralysis, and other conditions. The initiative has been highly controversial among stakeholders and watchdog groups concerned with organizational transparency, accountability, and the ethics of stem cell research. We interviewed major stakeholders—both supporters and opponents—and analyzed documents and meeting notes. We found that the CIRM has overcome start-up challenges, been selectively influenced by criticism, and adhered to its core mission. PMID:20075315

High-capacity high-speed recording

NASA Astrophysics Data System (ADS)

Jamberdino, A. A.

1981-06-01

Continuing advances in wideband communications and information handling are leading to extremely large volume digital data systems for which conventional data storage techniques are becoming inadequate. The paper presents an assessment of alternative recording technologies for the extremely wideband, high capacity storage and retrieval systems currently under development. Attention is given to longitudinal and rotary head high density magnetic recording, laser holography in human readable/machine readable devices and a wideband recorder, digital optical disks, and spot recording in microfiche formats. The electro-optical technologies considered are noted to be capable of providing data bandwidths up to 1000 megabits/sec and total data storage capacities in the 10 to the 11th to 10 to the 12th bit range, an order of magnitude improvement over conventional technologies.

Emerging nondestructive inspection methods for aging aircraft

DOE Office of Scientific and Technical Information (OSTI.GOV)

Beattie, A; Dahlke, L; Gieske, J

This report identifies and describes emerging nondestructive inspection (NDI) methods that can potentially be used to inspect commercial transport and commuter aircraft for structural damage. The nine categories of emerging NDI techniques are: acoustic emission, x-ray computed tomography, backscatter radiation, reverse geometry x-ray, advanced electromagnetics, including magnetooptic imaging and advanced eddy current techniques, coherent optics, advanced ultrasonics, advanced visual, and infrared thermography. The physical principles, generalized performance characteristics, and typical applications associated with each method are described. In addition, aircraft inspection applications are discussed along with the associated technical considerations. Finally, the status of each technique is presented, with amore » discussion on when it may be available for use in actual aircraft maintenance programs. It should be noted that this is a companion document to DOT/FAA/CT-91/5, Current Nondestructive Inspection Methods for Aging Aircraft.« less

Availability of Japanese subsidies for international telemedicine projects.

PubMed

Nakajima, I; Tsurumi, T; Sawada, Y; Juzoji, H; Ogushi, Y

1999-10-01

In this article, the authors report the methods for obtaining subsidies for overseas telemedicine projects from Japanese sources based on their own personal experiences. The Japanese Government is already subsidizing such specialized NGOs (Non-Governmental Organizations) as the Telemedicine Society of Japan and Basic Human Needs and, Japanese trading companies are also hiring telemedicine experts. Prospective methods for obtaining subsidies are outlined as under the following headings: Assistance without compensation, Technology transfer, Grass-roots grant assistance, the Telecommunications Advancement Organization, Postal Savings for International Voluntary Aid, Venture business development funds provided by the Ministry of International Trade and Industry, Mission demonstration satellites by the National Space Development Agency of Japan, the Sasakawa Pacific Island Nations Fund, and International Communications Foundation. Key points of the applications are noted under (1) Degree of contribution to local residents, (2) Significance of project continuation and (3) Novelty and economic impact.

Research, Development and Demonstration (RD&D) Needs for Light Water Reactor (LWR) Technologies A Report to the Reactor Technology Subcommittee of the Nuclear Energy Advisory Committee (NEAC) Office of Nuclear Energy U.S. Department of Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCarthy, Kathryn A.; Adams, Bradley J.

The LWR RD&D Working Group developed a detailed list of RD&D suggestions and recommendations, which are provided in Appendix D. The Working Group then undertook a systematic ranking process, described in Appendix E. The results of the ranking process are not meant to be a strict set of priorities, but rather should provide insight into how the items generally ranked within the Working Group. Future discussions and investigation into these items could provide information that would support a change in these priorities or in their emphasis. The results of this prioritization are provided below. Note that in general, many RD&Dmore » ideas are applicable to both new Advanced Light Water Reactor (ALWR) plants and currently operating plants.« less

Research needs and priorities for transition and employment in autism: Considerations reflected in a "Special Interest Group" at the International Meeting for Autism Research.

PubMed

Nicholas, David B; Hodgetts, Sandra; Zwaigenbaum, Lonnie; Smith, Leann E; Shattuck, Paul; Parr, Jeremy R; Conlon, Olivia; Germani, Tamara; Mitchell, Wendy; Sacrey, Lori; Stothers, Margot E

2017-01-01

Research related to supports for adults with autism spectrum disorder (ASD) is under-developed. As an example, system and service development to support successful transition to adulthood and meaningful vocation for adults has received relatively little research scrutiny until recently, with practitioners and program developers lacking evidenceinformed approaches guiding service delivery. A Special Interest Group (SIG) was convened at the International Meeting for Autism Research in May 2014 and May 2015, with a focus on transitional and vocational issues in ASD. The SIG consisted of 120 international delegates, including self-advocates, family members, researchers, program and policy developers, practitioners, and interdisciplinary ASD trainees. Following a summary of the literature, subgroups of attendees were convened in smaller groups to identify research needs and priorities. International researchers facilitated these discussions with notes taken in each subgroup. Using a qualitative analytic approach, key themes across groups were identified. These key themes, outlined in this paper, address the identified need to (a) advance research capacity; (b) build employer capacity relative to employing persons with ASD; and (c) enhance support resources for adults with ASD and their families. Heightened research activity guiding practice and policy, community/employer engagement, and person and family-centered services were recommended. Implications for advancement and implementation are offered. Autism Res 2017, 10: 15-24. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

Parallel Note-Taking: A Strategy for Effective Use of Webnotes

ERIC Educational Resources Information Center

Pardini, Eleanor A.; Domizi, Denise P.; Forbes, Daniel A.; Pettis, Gretchen V.

2005-01-01

Many instructors supply online lecture notes but little attention has been given to how students can make the best use of this resource. Based on observations of student difficulties with these notes, a strategy called parallel note-taking was developed for using online notes. The strategy is a hybrid of research-proven strategies for effective…

Path to a UV/Optical/IR Flagship: Review of ATLAST and Its Predecessors

NASA Technical Reports Server (NTRS)

Thronson, Harley; Bolcar, Matthew R.; Clampin, Mark; Crooke, Julie; Feinberg, Lee; Oegerle, William; Rioux, Norman; Stahl, H. Philip; Stapelfeldt, Karl

2016-01-01

Our recently completed study for the Advanced Technology Large-Aperture Space Telescope (ATLAST) was the culmination of three years of initially internally funded work that built upon earlier engineering designs, science objectives, and technology priorities. Beginning in the mid-1980s, multiple teams of astronomers, technologists, and engineers developed concepts for a large-aperture UV/optical/IR space observatory intended to follow the Hubble Space Telescope (HST). Here, we summarize since the first significant conferences on major post-HST ultraviolet, optical, and infrared (UVOIR) observatories the history of designs, scientific goals, key technology recommendations, and community workshops. Although the sophistication of science goals and the engineering designs both advanced over the past three decades, we note the remarkable constancy of major characteristics of large post-HST UVOIR concepts. As it has been a priority goal for NASA and science communities for a half-century, and has driven much of the technology priorities for major space observatories, we include the long history of concepts for searching for Earth-like worlds. We conclude with a capsule summary of our ATLAST reference designs developed by four partnering institutions over the past three years, which was initiated in 2013 to prepare for the 2020 National Academies' Decadal Survey.

Why Gene Editors Like CRISPR/Cas May Be a Game-Changer for Neuroweapons

PubMed Central

Giordano, James

2017-01-01

This year marks the Eighth Review Conference (RevCon) of the Biological Toxins and Weapons Convention (BWC). At the same time, ongoing international efforts to further and more deeply investigate the brain's complex neuronal circuitry are creating unprecedented capabilities to both understand and control neurological processes of thought, emotion, and behavior. These advances have tremendous promise for human health, but the potential for their misuse has also been noted, with most discussions centering on research and development of agents that are addressed by existing BWC and Chemical Weapons Convention (CWC) proscriptions. In this article, we discuss the dual-use possibilities fostered by employing emergent biotechnologic techniques and tools—specifically, novel gene editors like clustered regular interspaced short palindromic repeats (CRISPR)—to produce neuroweapons. Based on our analyses, we posit the strong likelihood that development of genetically modified or created neurotropic substances will advance apace with other gene-based therapeutics, and we assert that this represents a novel—and realizable—path to creating potential neuroweapons. In light of this, we propose that it will be important to re-address current categorizations of weaponizable tools and substances, so as to better inform and generate tractable policy to enable improved surveillance and governance of novel neuroweapons. PMID:28574731

Advanced composites in Japan

NASA Technical Reports Server (NTRS)

Diefendorf, R. Judd; Hillig, William G.; Grisaffe, Salvatore J.; Pipes, R. Byron; Perepezko, John H.; Sheehan, James E.

1994-01-01

The JTEC Panel on Advanced Composites surveyed the status and future directions of Japanese high-performance ceramic and carbon fibers and their composites in metal, intermetallic, ceramic, and carbon matrices. Because of a strong carbon and fiber industry, Japan is the leader in carbon fiber technology. Japan has initiated an oxidation-resistant carbon/carbon composite program. With its outstanding technical base in carbon technology, Japan should be able to match present technology in the U.S. and introduce lower-cost manufacturing methods. However, the panel did not see any innovative approaches to oxidation protection. Ceramic and especially intermetallic matrix composites were not yet receiving much attention at the time of the panel's visit. There was a high level of monolithic ceramic research and development activity. High temperature monolithic intermetallic research was just starting, but notable products in titanium aluminides had already appeared. Matrixless ceramic composites was one novel approach noted. Technologies for high temperature composites fabrication existed, but large numbers of panels or parts had not been produced. The Japanese have selected aerospace as an important future industry. Because materials are an enabling technology for a strong aerospace industry, Japan initiated an ambitious long-term program to develop high temperature composites. Although just starting, its progress should be closely monitored in the U.S.

Theory versus practice in Strategic Environmental Assessment (SEA)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lobos, Víctor, E-mail: vlobosg@gmail.com; Centro de Estudios del Desarrollo, San Crescente 551, Las Condes, Santiago; Partidario, Maria

Could the theory of Strategic Environmental Assessment (SEA) be ahead of its time and decoupled from its practice? This paper evolved in search for this leading research question. Over the years the discourse on SEA experienced a gradual shift from the technocratic and rationalist thinking that supported its origin to more strategic approaches and integrated concepts, suggested since the mid 1990's. In this paper we share the results of our analysis of international thinking and practical experience with SEA. Results reveal that SEA practice changes very slowly when compared to advanced thinking supporting the noted shift. Current SEA practice showsmore » to be still predominantly rooted in the logic of projects' environmental impact assessment (EIA). It is strongly bound to legal and regulatory requirements, and the motivation for its application persists being the delivery of environmental (or final) reports to meet legal obligations. Even though advanced SEA theoretical thinking claim its potential to help decisions to look forward, change mind-sets and the rationale of decision-making to meet sustainability challenges and enhance societal values, we note a weak relationship between the theoretical development of SEA and its practice. Why is this happening? Which factors explain this apparent inertia, resistance to change, in the SEA practice? Results appear to demonstrate the influence of assumptions, understandings, concepts, and beliefs in the use of SEA, which in turn suggest the political sensitivity of the instrument. - Highlights: • Theoretical thinking in SEA is ahead of its time. • SEA international practice reveals inertia to move out of project’ EIA comfort zone. • World current SEA practice show similar understandings of 30 years ago. • 100 world reports and survey of practitioners supported world review. • SEA great challenge is to change paradigms into new scientific complexity theories.« less

In-Space Propulsion Program Overview and Status

NASA Technical Reports Server (NTRS)

Carroll, Carol; Johnson, Les; Baggett, Randy

2002-01-01

NASA's In-Space Propulsion (ISP) Program is designed to develop advanced propulsion technologies that can enable or greatly enhance near and mid-term NASA science missions by significantly reducing cost, mass, and/or travel times. These technologies include: Electric Propulsion (Solar and Nuclear Electric) [note: The Nuclear Electric Propulsion work will be transferred to the NSI program in FY03]; Propellantless Propulsion (aerocapture, solar sails, plasma sails, and momentum exchange tethers); Advanced Chemical Propulsion. The ISP approach to identifying and prioritizing these most promising technologies is to use mission analysis and subsequent peer review. These technologies under consideration are mid-Technology Readiness Level (TRL) up to TRL-6 for incorporation into mission planning within three - five years of initiation. In addition, maximum use of open competition is encouraged to seek optimum solutions under ISP. Several NASA Research Announcements (NRAs) have been released asking industry, academia and other organizations to propose propulsion technologies designed to improve our ability to conduct scientific study of the outer planets and beyond. The ISP Program is managed by NASA HQ (Headquarters) and implemented by the Marshall Space Flight Center in Huntsville, Alabama.

Sandia SWiFT Wind Turbine Manual.

DOE Office of Scientific and Technical Information (OSTI.GOV)

White, Jonathan; LeBlanc, Bruce Philip; Berg, Jonathan Charles

The Scaled Wind Farm Technology (SWiFT) facility, operated by Sandia National Laboratories for the U.S. Department of Energy's Wind and Water Power Program, is a wind energy research site with multiple wind turbines scaled for the experimental study of wake dynamics, advanced rotor development, turbine control, and advanced sensing for production-scale wind farms. The SWiFT site currently includes three variable-speed, pitch-regulated, three-bladed wind turbines. The six volumes of this manual provide a detailed description of the SWiFT wind turbines, including their operation and user interfaces, electrical and mechanical systems, assembly and commissioning procedures, and safety systems. Further dissemination only asmore » authorized to U.S. Government agencies and their contractors; other requests shall be approved by the originating facility or higher DOE programmatic authority. 111 UNCLASSIFIED UNLIMITED RELEASE Sandia SWiFT Wind Turbine Manual (SAND2016-0746 ) approved by: Department Manager SWiFT Site Lead Dave Minster (6121) Date Jonathan White (6121) Date SWiFT Site Supervisor Dave Mitchell (6121) Date Note: Document revision logs are found after the title page of each volume of this manual. iv« less

Insect growth regulators and insect control: a critical appraisal.

PubMed Central

Siddall, J B

1976-01-01

Insect growth regulators (IGRs) of the juvenile hormone type alter physiological processes essential to insect development and appear to act specifically on insects. Three natural juvenile hormones have been found in insects but not in other organisms. Future use of antagonists or inhibitors of hormone synthesis may be technically possible as an advantageous extension of pest control by IGRs. A documented survey of the properties, metabolism, toxicology, and uses of the most commercially advanced chemical, methoprene, shows it to be environmentally acceptable and toxicologically innocuous. Derivation of its current use patterns is discussed and limitations on these are noted. Residue levels and their measurement in the ppb region have allowed exemption from the requirement of tolerances in the EPA registered use of methoprene for mosquito control. Tolerances for foods accompany its fully approved use for control of manure breeding flies through a cattle feed supplement. The human health effects of using this chemical appear to be purely beneficial, but further advances through new IGR chemicals appear unlikely without major changes in regulatory and legislative policy. PMID:976222

Natural orifice translumenal endoscopic surgery (NOTES): emerging trends and specifications for a virtual simulator.

PubMed

Schwaitzberg, Steven D; Dorozhkin, Denis; Sankaranarayanan, Ganesh; Matthes, Kai; Jones, Daniel B; De, Suvranu

2016-01-01

A virtual translumenal endoscopic surgical trainer (VTEST) is being developed to accelerate the development of natural orifice translumenal endoscopic surgery (NOTES) procedures and devices in a safe and risk-free environment. For a rapidly developing field such as NOTES, a needs analysis must be conducted regularly to discover emerging research trends and areas of potential high impact for a virtual simulator. This paper presents a survey-based study which follows a similar study conducted by this group in 2011 (Sankaranarayanan et al. in Surg Endosc 27:1607-1616, 2013). A 32-point questionnaire was distributed at the 2012 Natural Orifice Surgery Consortium for Assessment and Research annual meeting. These data were subsequently augmented by an identical online survey, targeted at the members of the American Society for Gastrointestinal Endoscopy and the Society of American Gastrointestinal and Endoscopic Surgeons, and analyzed. Twenty-eight NOTES experts participated in the 2012 study. Cholecystectomy (CE) procedure remained the most commonly performed NOTES technique, with 18 positive responses (64%). In contrast to 2011, the popularity of the NOTES appendectomy (AE) was significantly lower, with only 2 (7%) instances (CE vs. AE, p < 0.001), while the number of peroral endoscopic myotomy (POEM, PE) cases had increased significantly, with 11 (39%) positive responses, respectively (PE vs. AE, p = 0.013). Strong preference toward hybrid rather than pure NOTES techniques (82 vs. 11%, p < 0.001) was also expressed. Other responses were similar to those in the 2011 study, with the VTEST™ utility in developing and testing new techniques and instruments ranked particularly high. Based on the results of this study, a decision was made to focus exclusively on the transvaginal hybrid NOTES cholecystectomy procedure, including both rigid and flexible scope techniques. The importance of developing a virtual NOTES simulator was reaffirmed, with POEM identified as a promising candidate for future simulator development.

LUVOIR Tech Notes

NASA Technical Reports Server (NTRS)

Bolcar, Matthew R.; Shaklan, Stuart; Roberge, Aki; Rioux, Norman; Feinberg, Lee; Werner, Michael; Rauscher, Bernard; Mandell, Avi; France, Kevin; Schiminovich, David

2016-01-01

We present nine "tech notes" prepared by the Large UV/Optical/Infrared (LUVOIR) Science and Technology Definition Team (STDT), Study Office, and Technology Working Group. These tech notes are intended to highlight technical challenges that represent boundaries in the trade space for developing the LUVOIR architecture that may impact the science objectives being developed by the STDT. These tech notes are intended to be high-level discussions of the technical challenges and will serve as starting points for more in-depth analysis as the LUVOIR study progresses.

The role of standards in the development and implementation of clinical laboratory tests: a domestic and global perspective.

PubMed

Michaud, Ginette Y

2005-01-01

In the field of clinical laboratory medicine, standardization is aimed at increasing the trueness and reliability of measured values. Standardization relies on the use of written standards, reference measurement procedures and reference materials. These are important tools for the design and validation of new tests, and for establishing the metrological traceability of diagnostic assays. Their use supports the translation of research technologies into new diagnostic assays and leads to more rapid advances in science and medicine, as well as improvements in the quality of patient care. The various standardization tools are described, as are the procedures by which written standards, reference procedures and reference materials are developed. Recent efforts to develop standards for use in the field of molecular diagnostics are discussed. The recognition of standardization tools by the FDA and other regulatory authorities is noted as evidence of their important role in ensuring the safety and performance of in vitro diagnostic devices.

An horizon scan of biogeography

PubMed Central

2014-01-01

The opportunity to reflect broadly on the accomplishments, prospects, and reach of a field may present itself relatively infrequently. Each biennial meeting of the International Biogeography Society showcases ideas solicited and developed largely during the preceding year, by individuals or teams from across the breadth of the discipline. Here, we highlight challenges, developments, and opportunities in biogeography from that biennial synthesis. We note the realized and potential impact of rapid data accumulation in several fields, a renaissance for inter-disciplinary research, the importance of recognizing the evolution–ecology continuum across spatial and temporal scales and at different taxonomic, phylogenetic and functional levels, and re-exploration of classical assumptions and hypotheses using new tools. However, advances are taxonomically and geographically biased, and key theoretical frameworks await tools to handle, or strategies to simplify, the biological complexity seen in empirical systems. Current threats to biodiversity require unprecedented integration of knowledge and development of predictive capacity that may enable biogeography to unite its descriptive and hypothetico-deductive branches and establish a greater role within and outside academia. PMID:24707348

SiC lightweight telescopes for advanced space applications. II - Structures technology

NASA Technical Reports Server (NTRS)

Anapol, Michael I.; Hadfield, Peter; Tucker, Theodore

1992-01-01

A critical technology area for lightweight SiC-based telescope systems is the structural integrity and thermal stability over spaceborne environmental launch and thermal operating conditions. Note, it is highly desirable to have an inherently athermal design of both SiC mirrors and structure. SSG has developed an 8 inch diameter SiC telescope system for brassboard level optical and thermal testing. The brassboard telescope has demonstrated less than 0.2 waves P-V in the visible wavefront change over +50 C to -200 C temperature range. SSG has also fabricated a SiC truss structural assembly and successfully qualified this hardware at environmental levels greater than 3 times higher than normal Delta, Titan, and ARIES launch loads. SSG is currently developing two SiC telescopes; an 20 cm diameter off-axis 3 mirror re-imaging and a 60 cm aperture on-axis 3 mirror re-imager. Both hardware developments will be tested to flight level environmental, optical, and thermal specifications.

Composable Distributed Access Control and Integrity Policies for Query-Based Wireless Sensor Networks

DTIC Science & Technology

2008-03-01

unaltered during transmission and verified with data authentication. Data Freshness describes the ordering and currency of data. Strong freshness is a total...Advances in Cryptology — Crypto ’97, volume 1294 of Lecture Notes in Computer Science, pages 180–197. Springer-Verlag, Berlin, 1997. GS04. Saurabh

78 FR 34584 - Approval and Promulgation of Air Quality Implementation Plans; Pennsylvania; Allegheny County...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... National Technology Transfer and Advancement Act of 1995 (15 U.S.C. 272 note) because application of those... Technology Under the 8-Hour Ozone National Ambient Air Quality Standard AGENCY: Environmental Protection... reasonably available control technology (RACT) for nitrogen oxides (NO X ) and volatile organic compounds...

77 FR 37359 - Revisions to the California State Implementation Plan, South Coast Air Quality Management...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

... National Technology Transfer and Advancement Act of 1995 (15 U.S.C. 272 note) because application of those... Business Information (CBI) or other information whose disclosure is restricted by statute. Information that... business hours with the contact listed in the FOR FURTHER INFORMATION CONTACT section. FOR FURTHER...

78 FR 72020 - Drawbridge Operation Regulation; Passaic River, Kearney and Newark, NJ

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-02

... National Technology Transfer and Advancement Act (NTTAA) (15 U.S.C. 272 note) directs agencies to use... Proposed Rulemaking Sec. Section Symbol U.S.C. United States Code A. Regulatory History and Information On... rulemaking. The Coast Guard received no comments from the Small Business Administration on this rule. The...

Universal Newborn Screening and Adverse Medical Outcomes: A Historical Note

ERIC Educational Resources Information Center

Brosco, Jeffrey P.; Seider, Michael I.; Dunn, Angela C.

2006-01-01

Universal newborn screening programs for metabolic disorders are typically described as a triumph of medicine and public policy in the US over the last 50 years. Advances in science and technology, including the Human Genome Project, offer the opportunity to expand universal newborn screening programs to include many additional metabolic and…

The Design of an Intelligent Decision Support Tool for Submarine Commanders

DTIC Science & Technology

2009-06-01

for public release, distribution unlimited 13. SUPPLEMENTARY NOTES The original document contains color images . 14. ABSTRACT 15. SUBJECT TERMS 16...with research supporting the advancement of military technology. Thank you again for your support throughout this process . To Dave Silvia and Carl...26 2.1.3 Voyage Management System

A Noted Physicist's Contrarian View of Global Warming

ERIC Educational Resources Information Center

Goldstein, Evan R., Comp.

2008-01-01

According to Freeman Dyson, an emeritus professor of physics at the Institute for Advanced Study, the debate about global warming has become too narrow and opinions have become too entrenched. Relying on a computer model designed by the Yale University economist William D. Nordhaus, Dyson compared the effectiveness and economic feasibility of…

Oregon Research Institute's Smoking Prevention Program: Helping Students Resist Peer Pressure.

ERIC Educational Resources Information Center

Severson, Herbert; And Others

1981-01-01

In 1980, Oregon Research Institute implemented Programs to Advance Teen Health (PATH), a smoking prevention program that helps seventh and ninth graders learn to resist social pressures to smoke. This report describes PATH and discusses the reasons behind its smoking prevention strategy. The report first notes the importance of preventing…

TARDEC’s VICTORY SIL is a Key Tool for Advancing Standardized Ground Vehicle Electronic Architecture

DTIC Science & Technology

2012-08-06

SUPPLEMENTARY NOTES Submitted to 2012 NDIA Ground Vehicle Systems Engineering and Technology Symposium August 14-16 Troy , Michigan 14. ABSTRACT VICTORY...Timing, Threat and Remote Weapons Station. The results were very encouraging with very low power consumption (3.15 Watts ), less than 1% system

Progress Report on Alzheimer Disease: Volume III.

ERIC Educational Resources Information Center

National Inst. on Aging (DHHS/PHS), Bethesda, MD.

This report summarizes advances in the understanding of Alzheimer's disease, the major cause of mental disability among older Americans. The demography of the disease is discussed, noting that approximately 2.5 million American adults are afflicted with the disease and that the large increase in the number of Alzheimer's disease patients is due to…

Oral Communication Apprehension: Reconceptualization and a New Look at Measurement.

ERIC Educational Resources Information Center

McCroskey, James C.

Noting that the communication apprehension (CA) construct advanced more than a decade ago is restricted to talking, this paper points out that the construct now encompasses all modes of communication, including writing and singing. The first section of the paper examines current conceptualizations of the CA construct and compares these to other…

Technology Transience and Distance Education in the Second Machine Age

ERIC Educational Resources Information Center

Swan, Karen

2015-01-01

In this article, the author explores how technological change is affecting most aspects of our society. In this vein, it is noted that even though education has historically been more resistant to technological change than other societal sectors, recent advances in distance education, specifically online learning, promise to radically disrupt…

Senator Mikulski Notes Exciting Endeavors at ATRF | Poster

Cancer.gov

By Andrea Frydl and Kristine Jones, Guest Writers, and Ken Michaels, Staff Writer On October 10, U.S. Senator Barbara Mikulski and Congressman Chris Van Hollen, both from Maryland, toured the Advanced Technology Research Facility (ATRF), accompanied by NCI Director Harold Varmus, Chief Technology Officer Atsuo Kuki, and other FNL leaders. Mikulski toured several Maryland

Dualism and Vocational Education and Training: Creating the People Who Require Training

ERIC Educational Resources Information Center

Zoellner, Don

2012-01-01

Governments in advanced liberal democracies have assigned Vocational Education and Training (VET) a critical role in preparing a productive workforce for the broader economy. This linkage opens the way to use economic theories to expand the understanding of VET. Noted economic theorists have described the use of one economic reductionist technique…

Cultural Impacts on Distance Learning, Online Learning Styles, and Design

ERIC Educational Resources Information Center

Alalshaikh, Sultan

2015-01-01

This article focuses on the multicultural nature of distance learners. To note, the heightened demand for higher education on a global scale, as well as rapid advancements in telecommunication technologies, have rendered online distance education as having potential for worldwide reach online schools in many countries. Because of this, online…

CODAP: Programmer Notes for the Subroutine Library on the Univac 1108.

ERIC Educational Resources Information Center

Weissmuller, Johnny J.; And Others

The Comprehensive Occupational Data Analysis Programs (CODAP) package is a highly interactive and efficient system of computer routines for analyzing, organizing, and reporting occupational information. Since its inception in 1960, CODAP has grown in tandem with advances in job analysis methodology and is now capable of answering most of the wide…

Digital Advances in Contemporary Audio Production.

ERIC Educational Resources Information Center

Shields, Steven O.

Noting that a revolution in sonic high fidelity occurred during the 1980s as digital-based audio production methods began to replace traditional analog modes, this paper offers both an overview of digital audio theory and descriptions of some of the related digital production technologies that have begun to emerge from the mating of the computer…

Success: The Way There Is More Fun than the Stay There.

ERIC Educational Resources Information Center

Trinchese, Toni

1978-01-01

The author notes that early sex stereotyping often prevents women from forming the aspirations and assertion skills necessary for occupational success. She describes how she escaped this conditioning and advanced herself by goal-setting and the help of role models. Part of a theme issue on women and leadership. (SJL)

Corporate Versus Academic Perceptions of the Need for Language Fluency.

ERIC Educational Resources Information Center

Vande Berg, Camille Kennedy

1997-01-01

Discusses the academic emphasis on students acquiring fluency in a second language to foster their advancement in the business world of international commerce. Notes that human resource experts in U.S.-based international corporations often give a low priority to linguistic fluency and emphasize the need for cultural expertise. (Seven references)…

USSR Space Life Sciences Digest

NASA Technical Reports Server (NTRS)

Lewis, C. S. (Editor); Donnelly, K. L. (Editor)

1980-01-01

Research in exobiology, life sciences technology, space biology, and space medicine and physiology, primarily using data gathered on the Salyut 6 orbital space station, is reported. Methods for predicting, diagnosing, and preventing the effects of weightlessness are discussed. Psychological factors are discussed. The effects of space flight on plants and animals are reported. Bioinstrumentation advances are noted.

How Sociological Leaders Rank Learning Goals for Introductory Sociology

ERIC Educational Resources Information Center

Persell, Caroline Hodges

2010-01-01

In 2001, the American Sociological Association launched a task force to articulate learning goals for an introduction to sociology course and design an advanced high school sociology curriculum that could also be a model for introductory sociology courses in colleges and universities. This research note describes one of several efforts to validate…

77 FR 75487 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of No Objection to...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-20

... of the Dodd-Frank Wall Street Reform and Consumer Protection Act (``Dodd-Frank Act''),\\1\\ entitled... proposed rule change discussed in the advance notice. \\1\\ Dodd-Frank Wall Street Reform and Consumer..., the Commission approval order notes that OCC retains discretion to employ different confidence levels...

Gender and Diversity in Organizations: Past, Present, and Future Directions.

ERIC Educational Resources Information Center

Murrell, Audrey J.; James, Erika Hayes

2001-01-01

Introduces a special issue on how the nature of organizations has changed in recent years and implications of these changes for the future. Discusses key issues that have been studied on gender and diversity in organizations (discrimination, affirmative action, barriers to career advancement, and sexual harassment). Notes strategies for enhancing…

76 FR 78571 - Approval and Promulgation of State Implementation Plans: Oregon

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-19

... Technology Transfer and Advancement Act of 1995 (15 U.S.C. 272 note) because application of those...: Rule 0010, What is the Employee Commute Options Program?; Rule 0020, Who is Subject to ECO?; Rule 0030, What Does ECO require?; Rule 0040, How Does the Department Enforce ECO?; Rule 0050, Definitions of...

Use of Information--LMC Connection

ERIC Educational Resources Information Center

Darrow, Rob

2005-01-01

Note taking plays an important part in the correct extracting of information from reference sources. The "Cornell Note Taking Method" initially developed as a method of taking notes during a lecture is well suited for taking notes from print sources and is one of the best "Use of Information" methods.

State-of-the-art of high-speed propeller noise prediction - A multidisciplinary approach and comparison with measured data

NASA Technical Reports Server (NTRS)

Dunn, Mark H.; Farassat, F.

1990-01-01

The results of NASA's Propeller Test Assessment program involving extensive flight tests of a large-scale advanced propeller are presented. This has provided the opportunity to evaluate the current capability of advanced propeller noise prediction utilizing principally the exterior acoustic measurements for the prediction of exterior noise. The principal object of this study was to evaluate the state-of-the-art of noise prediction for advanced propellers utilizing the best available codes of the disciplines involved. The effects of blade deformation on the aerodynamics and noise of advanced propellers were also studied. It is concluded that blade deformation can appreciably influence propeller noise and aerodynamics, and that, in general, centrifugal and blade forces must both be included in the calculation of blade forces. It is noted that the present capability for free-field noise prediction of the first three harmonics for advanced propellers is fairly good. Detailed data and diagrams of the test results are presented.

Treatment outcomes in locally advanced colorectal carcinoma

PubMed Central

Harish, K; Narayanaswamy, YV; Nirmala, S

2004-01-01

Background Locally advanced colorectal cancers form a distinct subgroup where contiguous organs could be involved without distant metastases and so may be amenable to curative surgical resection. It was our objective to report our experience in treating six such patients with operable locally advanced colorectal carcinomas. Methods We retrospectively reviewed the case notes of 47 patients who were diagnosed with colorectal cancers at M S Ramaiah Medical Teaching Hospital between the years 1996 – 2001. Six patients were identified with T4 lesions, adjacent organ involvement and with no nodal involvement. The treatments and outcomes for these patients were then reviewed. Results Two of three patients with rectal malignancies who underwent pelvic exenteration succumbed to disease recurrence within the first 18 months. One of the three patients with colonic cancers died of non malignant causes. The other two are disease free till date. Conclusions Aggressive multivisceral resections for locally advanced colonic cancers might be appropriate. Rectal cancers when locally advanced may be considered for pelvic exenteration, but a more guarded prognosis may apply. PMID:15527504

Application of advanced techniques for the assessment of bio-stability of biowaste-derived residues: A minireview.

PubMed

Lü, Fan; Shao, Li-Ming; Zhang, Hua; Fu, Wen-Ding; Feng, Shi-Jin; Zhan, Liang-Tong; Chen, Yun-Min; He, Pin-Jing

2018-01-01

Bio-stability is a key feature for the utilization and final disposal of biowaste-derived residues, such as aerobic compost or vermicompost of food waste, bio-dried waste, anaerobic digestate or landfilled waste. The present paper reviews conventional methods and advanced techniques used for the assessment of bio-stability. The conventional methods are reclassified into two categories. Advanced techniques, including spectroscopic (fluorescent, ultraviolet-visible, infrared, Raman, nuclear magnetic resonance), thermogravimetric and thermochemolysis analysis, are emphasized for their application in bio-stability assessment in recent years. Their principles, pros and cons are critically discussed. These advanced techniques are found to be convenient in sample preparation and to supply diversified information. However, the viability of these techniques as potential indicators for bio-stability assessment ultimately lies in the establishment of the relationship of advanced ones with the conventional methods, especially with the methods based on biotic response. Furthermore, some misuses in data explanation should be noted. Copyright © 2017 Elsevier Ltd. All rights reserved.

Secondary Traumatization in Psychiatric Mental Health Nurses: Validation of Five Key Concepts.

PubMed

Hubbard, Grace B; Beeber, Linda; Eves, Erin

2017-04-01

The purpose of this study was to validate five concepts central to secondary traumatization (ST) using narratives of psychiatric mental health advanced practice nurses. The study was designed as a directed content analysis of narrative notes (N-30). Consistency was found between narrative notes and the concepts. This study revealed that exposure and vulnerability precede empathic engagement, reaction, and alteration/transformation. The bidirectional outcome of alteration/transformation suggested that conditions leading to ST could have a positive outcome. Failure to recognize symptoms of ST and provide reflective supervision may compromise the nurse's ability to maintain a work-life balance and provide quality patient care. © 2015 Wiley Periodicals, Inc.

Melanie Klein and Repression: an examination of some unpublished Notes of 1934.

PubMed

Hinshelwood, R D

2006-01-01

Fifteen pages of unpublished Notes were found in the Melanie Klein Archives dating from early 1934, a crucial moment in Klein's development. She was at this time, 1934, moving away from child analysis, whilst also rethinking and revising her allegiance to Karl Abraham's theory of the phases of libidinal development. These Notes, entitled "Early Repression Mechanism," show Klein struggling to develop what became her characteristic theories of the depressive position and the paranoid-schizoid position. Although these Notes are precursors of the paper Klein gave later to the IPA Congress in 1934, they also show the origins of the emphasis she and her followers eventually gave to "splitting" rather than repression. The Notes give us an insight into the way that she worked clinically at the time. We see Klein's confidence develop as she diverged from the classical theories and technique. Her ideas were based on close attention to the detail of her clinical material, rather than attacking theoretical problems directly. The Notes show her method of struggling to her own conclusions, and they offer us a chance to grasp the roots of the subsequent controversy over Kleinian thought.

Incidence of postoperative delirium in patients undergoing total knee arthroplasty-an Asian perspective.

PubMed

Huang, Juncheng; Bin Abd Razak, Hamid Rahmatullah; Yeo, Seng Jin

2017-08-01

Very little is known in the literature with regards to the incidence of postoperative delirium following total knee arthroplasty (TKA) in Asians and the associated surgical factors. We conducted a retrospective study on incidence of postoperative delirium following TKA in Asians. One thousand sixteen knees of 954 consecutive patients who underwent TKA by the senior author of this study in the year 2006 were included in this review. All written and electronic medical records for patients were screened. Delirium was recorded to be present based on clinical entry onto the patients' inpatient hospital notes and a diagnosis made by psychiatrist based on the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). All statistical analysis was performed using SPSS v.18.0 (IBM Corp., Armonk, NY, USA). The incidence of postoperative delirium in our patients undergoing TKA was 0.59%. Six patients had a confirmed diagnosis of delirium postoperatively. We noted an association between a higher mean age (P<0.0001), a lower body mass index (P<0.0001), Chinese ethnicity (P=0.002), male gender (P=0.002) and chronic opioid use (P<0.0001) with incidence of post-operative delirium. We also noted a higher proportion of post-operative DVT (P<0.0001) and wound infection (P<0.0001) in the delirium group. The incidence of postoperative delirium in Asians undergoing TKA in our institution is very low at 0.59%. Advanced age, lower body mass index, Chinese ethnicity, male gender and preoperative chronic opioid use may be associated with developing postoperative delirium.

Advances in radiotherapy techniques and delivery for non-small cell lung cancer: benefits of intensity-modulated radiation therapy, proton therapy, and stereotactic body radiation therapy

PubMed Central

Diwanji, Tejan P.; Mohindra, Pranshu; Vyfhuis, Melissa; Snider, James W.; Kalavagunta, Chaitanya; Mossahebi, Sina; Yu, Jen; Feigenberg, Steven

2017-01-01

The 21st century has seen several paradigm shifts in the treatment of non-small cell lung cancer (NSCLC) in early-stage inoperable disease, definitive locally advanced disease, and the postoperative setting. A key driver in improvement of local disease control has been the significant evolution of radiation therapy techniques in the last three decades, allowing for delivery of definitive radiation doses while limiting exposure of normal tissues. For patients with locally-advanced NSCLC, the advent of volumetric imaging techniques has allowed a shift from 2-dimensional approaches to 3-dimensional conformal radiation therapy (3DCRT). The next generation of 3DCRT, intensity-modulated radiation therapy and volumetric-modulated arc therapy (VMAT), have enabled even more conformal radiation delivery. Clinical evidence has shown that this can improve the quality of life for patients undergoing definitive management of lung cancer. In the early-stage setting, conventional fractionation led to poor outcomes. Evaluation of altered dose fractionation with the previously noted technology advances led to advent of stereotactic body radiation therapy (SBRT). This technique has dramatically improved local control and expanded treatment options for inoperable, early-stage patients. The recent development of proton therapy has opened new avenues for improving conformity and the therapeutic ratio. Evolution of newer proton therapy techniques, such as pencil-beam scanning (PBS), could improve tolerability and possibly allow reexamination of dose escalation. These new progresses, along with significant advances in systemic therapies, have improved survival for lung cancer patients across the spectrum of non-metastatic disease. They have also brought to light new challenges and avenues for further research and improvement. PMID:28529896

24 CFR 232.525 - Note and security form.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Note and security form. 232.525 Section 232.525 Housing and Urban Development Regulations Relating to Housing and Urban Development... URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER AUTHORITIES...

Development and Evaluation of a Clinical Note Section Header Terminology

PubMed Central

Denny, Joshua C.; Miller, Randolph A.; Johnson, Kevin B.; Spickard, Anderson

2008-01-01

Clinical documentation is often expressed in natural language text, yet providers often use common organizations that segment these notes in sections, such as “history of present illness” or “physical examination.” We developed a hierarchical section header terminology, supporting mappings to LOINC and other vocabularies; it contained 1109 concepts and 4332 synonyms. Physicians evaluated it compared to LOINC and the Evaluation and Management billing schema using a randomly selected corpus of history and physical notes. Evaluated documents contained a median of 54 sections and 27 “major sections.” There were 16,196 total sections in the evaluation note corpus. The terminology contained 99.9% of the clinical sections; LOINC matched 77% of section header concepts and 20% of section header strings in those documents. The section terminology may enable better clinical note understanding and interoperability. Future development and integration into natural language processing systems is needed. PMID:18999303

Investigating ESL Learners' Lexical Collocations: The Acquisition of Verb + Noun Collocations by Japanese Learners of English

ERIC Educational Resources Information Center

Miyakoshi, Tomoko

2009-01-01

Although it is widely acknowledged that collocations play an important part in second language learning, especially at intermediate-advanced levels, learners' difficulties with collocations have not been investigated in much detail so far. The present study examines ESL learners' use of verb-noun collocations, such as "take notes," "place an…

77 FR 37326 - Safety Zone; Grand Hotel 125th Anniversary Fireworks Celebration, Mackinaw Island, MI

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-21

... National Technology Transfer and Advancement Act (NTTAA) (15 U.S.C. 272 note) directs agencies to use... Rulemaking A. Regulatory History and Information The Coast Guard is issuing this temporary final rule without.... Assistance for Small Entities Under section 213(a) of the Small Business Regulatory Enforcement Fairness Act...

Security. Review Software for Advanced CHOICE. CHOICE (Challenging Options in Career Education).

ERIC Educational Resources Information Center

Pitts, Ilse M.; And Others

CHOICE Security is an Apple computer game activity designed to help secondary migrant students memorize their social security numbers and reinforce job and role information presented in "Career Notes, First Applications." The learner may choose from four time options and whether to have the social security number visible on the screen or…

Note-Taking and Secondary Students with Learning Disabilities: Challenges and Solutions

ERIC Educational Resources Information Center

Boyle, Joseph R.

2012-01-01

As more secondary students with learning disabilities (LD) enroll in advanced content-area classes and are expected to pass state exams, they are faced with the challenge of mastering difficult concepts and abstract vocabulary while learning content. Once in these classes, students must learn from lectures that move at a quick pace, record…

Aromatic Ring Currents Illustrated--NMR Spectra of Tin(IV) Porphyrin Complexes. An Advanced Undergraduate Experiment.

ERIC Educational Resources Information Center

Arnold, Dennis P.

1988-01-01

Attempts to show that in the closed loops of cyclic structures the protons situated in conic regions above and below the ring will be shielded. Uses the diamagnetic and air stable octahedral tin(IV) complexes of porphyrins for study. Notes complexes crystallize easily and offer spectacular purple colors. (MVL)

Completing Algebra II in High School: Does It Increase College Access and Success?

ERIC Educational Resources Information Center

Kim, Jeongeun; Kim, Jiyun; DesJardins, Stephen L.; McCall, Brian P.

2015-01-01

Noting the benefits of mathematics in students' future educational attainment and labor market success, there is considerable interest in high school requirements in terms of course-taking in mathematics at the national, state, and school district level. Previous research indicates that taking advanced math courses in high school leads to positive…

A Comparative Study of a Research-Oriented High School Advanced Biology Class and a Conventional Textbook-Centered Class.

ERIC Educational Resources Information Center

Smith, Alva Nelson

Two instructional methods were identified and compared to determine if any significant differences could be noted on three criterion measures. Measurements were conducted in the areas of achievement in biology, science attitudes, and critical thinking ability. Student ability was measured using pre-tests and the Scholastic Aptitude Test. Students…

Use of Advance Directives: A Social Work Perspective on the Myth versus the Reality.

ERIC Educational Resources Information Center

Hoffman, Molly K.

1994-01-01

Considers Directive to Physician, Durable Power of Attorney for Healthcare Decisions, and Medical Ethics Decision Form. Notes importance of process individuals go through in defining what quality of life means to them. Sees current struggle being individual articulation of one's wishes based on personal definition of quality of life set forth in…

Dedication and Teamwork Highlight Efforts to Advance Normal Birth

PubMed Central

Humenick, Sharron S.

2006-01-01

The editor of The Journal of Perinatal Education describes the contents of this issue, which offer a broad range of resources, research, and inspiration for childbirth educators in their efforts to promote normal birth. Also, the editor notes the outstanding quality of dedication and teamwork among many who are involved in producing this quarterly, peer-reviewed journal.

Extending Research on the Victim-Offender Overlap: Evidence from a Genetically Informative Analysis

ERIC Educational Resources Information Center

Barnes, J. C.; Beaver, Kevin M.

2012-01-01

Criminologists have long noted that offenders are more likely to be the victims of crime as compared to nonoffenders. What has not been established, however, is "why" there is a significant degree of victim-offender overlap. While numerous explanations have been advanced and a significant number of studies have been conducted, there…

Galileo's Treatment for the Centre of Gravity of Solids

ERIC Educational Resources Information Center

Worner, C. H.; Iommi-Amunategui, G.

2007-01-01

The appendix on the centres of gravity that appears at the end of Galileo's book, "Two New Sciences", is analysed. It is shown that the method used by Galileo in this work has an interesting reasoning and also shows preliminary ideas about scaling and advances some ideas about series convergence. In addition, we note that the geometrical language…

75 FR 28249 - Comment Sought on Measures Designed To Assist U.S. Wireless Consumers To Avoid “Bill Shock”

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-20

... feasibility of instituting usage alerts and cut-off mechanisms similar to those required under the European... other things, the Commission noted that advances in technology, including usage alerts delivered via... the kind and degree of information available to consumers.'' On the issue of usage alerts, the...

TK3 eBook Software to Author, Distribute, and Use Electronic Course Content for Medical Education

ERIC Educational Resources Information Center

Morton, David A.; Foreman, K. Bo; Goede, Patricia A.; Bezzant, John L.; Albertine, Kurt H.

2007-01-01

The methods for authoring and distributing course content are undergoing substantial changes due to advancement in computer technology. Paper has been the traditional method to author and distribute course content. Paper enables students to personalize content through highlighting and note taking but does not enable the incorporation of multimedia…

Dense Neighborhoods and Mechanisms of Learning: Evidence from Children with Phonological Delay

ERIC Educational Resources Information Center

Gierut, Judith A.; Morrisette, Michele L.

2015-01-01

There is a noted advantage of dense neighborhoods in language acquisition, but the learning mechanism that drives the effect is not well understood. Two hypotheses--long-term auditory word priming and phonological working memory--have been advanced in the literature as viable accounts. These were evaluated in two treatment studies enrolling twelve…

The Need for a Speech Corpus

ERIC Educational Resources Information Center

Campbell, Dermot F.; McDonnell, Ciaran; Meinardi, Marti; Richardson, Bunny

2007-01-01

This paper outlines the ongoing construction of a speech corpus for use by applied linguists and advanced EFL/ESL students. In the first part, sections 1-4, the need for improvements in the teaching of listening skills and pronunciation practice for EFL/ESL students is noted. It is argued that the use of authentic native-to-native speech is…

Dramatic Growth Is Possible: Untangling Education's Gordian Knot

ERIC Educational Resources Information Center

Whittle, Chris

2006-01-01

In this article, the author discusses how, despite of the advances in today's technology, the way children are educated now is remarkably similar to how they were educated decades ago. More than any other modern-day institution, schooling is nearly impervious to change. He notes that America's "old school design" is not working with high degree of…

The Wait Is Over | Poster

Cancer.gov

By Nancy Parrish, Staff Writer At a March 2010 gathering at the construction site of the Advanced Technology Research Facility (ATRF), Craig Reynolds, Ph.D., associate director of the National Cancer Institute (NCI), noted that the facility would be a place where public–private partnerships will produce the next generation of diagnostics and treatments for cancer and AIDS. The

Critical Technology Determination for Future Human Space Flight

NASA Technical Reports Server (NTRS)

Mercer, Carolyn R.; Vangen, Scott D.; Williams-Byrd, Julie A.; Steckleim, Jonette M.; Alexander, Leslie; Rahman, Shamin A.; Rosenthal, Matthew; Wiley, Dianne S.; Davison, Stephan C.; Korsmeyer, David J.;

Critical Technology Determination for Future Human Space Flight

NASA Technical Reports Server (NTRS)

Mercer, Carolyn R.; Vangen, Scott D.; Williams-Byrd, Julie A.; Stecklein, Jonette M.; Rahman, Shamim A.; Rosenthal, Matthew E.; Hornyak, David M.; Alexander, Leslie; Korsmeyer, David J.; Tu, Eugene L.;

Trends and developments in industrial machine vision: 2013

NASA Astrophysics Data System (ADS)

Niel, Kurt; Heinzl, Christoph

2014-03-01

When following current advancements and implementations in the field of machine vision there seems to be no borders for future developments: Calculating power constantly increases, and new ideas are spreading and previously challenging approaches are introduced in to mass market. Within the past decades these advances have had dramatic impacts on our lives. Consumer electronics, e.g. computers or telephones, which once occupied large volumes, now fit in the palm of a hand. To note just a few examples e.g. face recognition was adopted by the consumer market, 3D capturing became cheap, due to the huge community SW-coding got easier using sophisticated development platforms. However, still there is a remaining gap between consumer and industrial applications. While the first ones have to be entertaining, the second have to be reliable. Recent studies (e.g. VDMA [1], Germany) show a moderately increasing market for machine vision in industry. Asking industry regarding their needs the main challenges for industrial machine vision are simple usage and reliability for the process, quick support, full automation, self/easy adjustment at changing process parameters, "forget it in the line". Furthermore a big challenge is to support quality control: Nowadays the operator has to accurately define the tested features for checking the probes. There is an upcoming development also to let automated machine vision applications find out essential parameters in a more abstract level (top down). In this work we focus on three current and future topics for industrial machine vision: Metrology supporting automation, quality control (inline/atline/offline) as well as visualization and analysis of datasets with steadily growing sizes. Finally the general trend of the pixel orientated towards object orientated evaluation is addressed. We do not directly address the field of robotics taking advances from machine vision. This is actually a fast changing area which is worth an own contribution.

The role of differentiation and standards-based grading in the science learning of struggling and advanced learners in a detracked high school honors biology classroom

NASA Astrophysics Data System (ADS)

MacDonald, Michelina Ruth Carter

The accountability movement in education resulting from the passage of The No Child Left Behind Act of 2001 has brought to light the disparities that exist in student achievement in the United States which play out along racial and socioeconomic lines. Three educational practices hold promise for reducing this achievement gap: differentiated instruction, standards-based assessment, and elimination of academic tracking. The purpose of this practitioner research study was to examine the ways that differentiation and standards-based assessment can support struggling learners and challenge advanced learners in a detracked, honors biology classroom. To gain insight into the role that differentiation and standards-based assessment played in supporting struggling and advanced learners, I used practitioner research to examine the development and implementation of a differentiated, standards-based instructional unit around the conceptual topic of protein synthesis. I collected multiple data pieces for 10 students in the study: two advanced learners, four struggling learners, and four strong learners who struggled in biology. Data analyzed included formative, self-, and summative assessment results; student artifacts; informal and formal student interviews; and, a practitioner reflection journal chronicling critical incidents and actions taken during the development and implementation of this unit and notes from peer debriefing during and following the unit's implementation. As I analyzed the data collected, my four findings fell into two overarching categories related to student grouping. My first three findings reflect what I learned about homogeneous grouping: (1) Pre-assessment based on unit outcomes is not useful for determining groups for tiered instruction; (2) Decisions about differentiation and grouping for differentiation must be made in the act of teaching using formative assessment results; and, (3) Flexible grouping structures are effective for both struggling and advanced learners. My fourth finding reflects what I learned about heterogeneous grouping: (4) Heterogeneously grouping students for argumentation through engagement in science inquiry serves both to reinforce proficiency of learning goals for struggling learners and simultaneously push all learners towards advanced proficiency. These findings indicate how planning for and implementing a differentiated, standards-based instructional unit can support the learning needs of both struggling and advanced learners in a detracked, honors biology classroom.

Pilot workload, performance and aircraft control automation

NASA Technical Reports Server (NTRS)

Hart, S. G.; Sheridan, T. B.

1984-01-01

Conceptual and practical issues associated with the design, operation, and performance of advanced systems and the impact of such systems on the human operators are reviewed. The development of highly automated systems is driven by the availability of new technology and the requirement that operators safely and economically perform more and more activities in increasingly difficult and hostile environments. It is noted that the operators workload may become a major area of concern in future design considerations. Little research was done to determine how automation and workload relate to each other, although it is assumed that the abstract, supervisory, or management roles that are performed by operators of highly automated systems will impose increased mental workload. The relationship between performance and workload is discussed in relation to highly complex and automated environments.

Investigating reliability attributes of silicon photovoltaic cells - An overview

NASA Technical Reports Server (NTRS)

Royal, E. L.

1982-01-01

Reliability attributes are being developed on a wide variety of advanced single-crystal silicon solar cells. Two separate investigations: cell-contact integrity (metal-to-silicon adherence), and cracked cells identified with fracture-strength-reducing flaws are discussed. In the cell-contact-integrity investigation, analysis of contact pull-strength data shows that cell types made with different metallization technologies, i.e., vacuum, plated, screen-printed and soldered, have appreciably different reliability attributes. In the second investigation, fracture strength was measured using Czochralski wafers and cells taken at various stages of processing and differences were noted. Fracture strength, which is believed to be governed by flaws introduced during wafer sawing, was observed to improve (increase) after chemical polishing and other process steps that tend to remove surface and edge flaws.

Note: Additionally refined new possibilities of plasma probe diagnostics.

PubMed

Riaby, V A; Savinov, V P; Masherov, P E; Yakunin, V G

2018-03-01

In two previous Notes published in this journal, a method of measuring probe sheath thickness and ion mass was described using Langmuir probe diagnostics in low pressure xenon plasma close to Maxwellian substance. According to the first Note, this method includes two stages: (i) in a special experiment with known ion mass, the Bohm and Child-Langmuir-Boguslavsky (CLB) equations for cylindrical Langmuir probes used in this xenon plasma were solved jointly to determine the probe sheath thicknesses and Bohm coefficient C BCyl ≈ 1.13; and (ii) in a general experiment, with known C BCyl , the same equations could be solved to obtain the probe sheath thicknesses and the mean ion mass. In the second Note, the (i) stage of this method was refined: the results of the CLB probe sheath model application, which were termed "evaluations," were corrected using the step-front probe sheath model, which was closer to reality in the special experiment with the xenon plasma. This process resulted in a Bohm coefficient of C BCyl ≈ 1.23 for the cylindrical probe. In the present Note, corrected xenon plasma parameters without the influence of the bare probe protective shield were used for the (i) stage of this diagnostic method. This action also refined the Bohm coefficient, lowering it to C BCyl ≈ 0.745 for cylindrical probes. This advance makes the new diagnostics method more objective and reliable.

Note: Additionally refined new possibilities of plasma probe diagnostics

NASA Astrophysics Data System (ADS)

Riaby, V. A.; Savinov, V. P.; Masherov, P. E.; Yakunin, V. G.

2018-03-01

In two previous Notes published in this journal, a method of measuring probe sheath thickness and ion mass was described using Langmuir probe diagnostics in low pressure xenon plasma close to Maxwellian substance. According to the first Note, this method includes two stages: (i) in a special experiment with known ion mass, the Bohm and Child-Langmuir-Boguslavsky (CLB) equations for cylindrical Langmuir probes used in this xenon plasma were solved jointly to determine the probe sheath thicknesses and Bohm coefficient CBCyl ≈ 1.13; and (ii) in a general experiment, with known CBCyl, the same equations could be solved to obtain the probe sheath thicknesses and the mean ion mass. In the second Note, the (i) stage of this method was refined: the results of the CLB probe sheath model application, which were termed "evaluations," were corrected using the step-front probe sheath model, which was closer to reality in the special experiment with the xenon plasma. This process resulted in a Bohm coefficient of CBCyl ≈ 1.23 for the cylindrical probe. In the present Note, corrected xenon plasma parameters without the influence of the bare probe protective shield were used for the (i) stage of this diagnostic method. This action also refined the Bohm coefficient, lowering it to CBCyl ≈ 0.745 for cylindrical probes. This advance makes the new diagnostics method more objective and reliable.

BASINS Technical Notes

EPA Pesticide Factsheets

EPA has developed several technical notes that provide in depth information on a specific function in BASINS. Technical notes can be used to answer questions users may have, or to provide additional information on the application of features in BASINS.

Simple, but not easy - Opportunities and challenges from teachers' and students' perspectives in the 21st century of veterinary parasitology teaching.

PubMed

Strube, Christina; Raue, Katharina; Janecek, Elisabeth

2018-03-15

One of the main goals in academia is, and has been, high quality education of students to provide theoretical and practical knowledge essential for professional life. Achieving this goal is highly dependent on teaching procedures and, consequently, on a constant adaptation of teaching styles to align to technical advances and cutting-edge topics. Technical advances can strongly influence teaching and learning in the complex subject area of veterinary parasitology. Today's students are provided with extensive, digital lecture notes, and e-learning offers including virtual microscope technology to independently obtain intensified theoretical knowledge and understanding. As veterinary parasitology is also highly reliant on proficient practical skills, lectures with integrated diagnostic exercises are mandatory. Nowadays, such practical skills, such as carrying out faecal examination procedures, can be strengthened by having access to clinical skills labs. Advances such as digital lecture notes, e-learning and virtual microscopes do not only provide new, innovative opportunities, but can also comprise challenges. In this context, provision of sufficient relevant studying material may discourage students to take on responsibilities for autonomous gathering of information. Besides technical advances, 'Zeitgeist' changes are shaping teaching contents, which are progressively expanding as zoonoses are increasingly being focused on. With the aim of adopting the one-health concept, students today are expected not only to bear responsibilities for animals, but also for their owners and public health. This article will cast light on some key challenges and opportunities in modern veterinary parasitology teaching from the teachers´ and the students´ perspectives. Copyright © 2018 Elsevier B.V. All rights reserved.

Developing the Storyline for an Advance Care Planning Video for Surgery Patients: Patient-Centered Outcomes Research Engagement from Stakeholder Summit to State Fair.

PubMed

Aslakson, Rebecca A; Schuster, Anne L R; Lynch, Thomas J; Weiss, Matthew J; Gregg, Lydia; Miller, Judith; Isenberg, Sarina R; Crossnohere, Norah L; Conca-Cheng, Alison M; Volandes, Angelo E; Smith, Thomas J; Bridges, John F P

2018-01-01

Patient-centered outcomes research (PCOR) methods and social learning theory (SLT) require intensive interaction between researchers and stakeholders. Advance care planning (ACP) is valuable before major surgery, but a systematic review found no extant perioperative ACP tools. Consequently, PCOR methods and SLT can inform the development of an ACP educational video for patients and families preparing for major surgery. The objective is to develop and test acceptability of an ACP video storyline. The design is a stakeholder-guided development of the ACP video storyline. Design-thinking methods explored and prioritized stakeholder perspectives. Patients and family members evaluated storyboards containing the proposed storyline. The study was conducted at hospital outpatient surgical clinics, in-person stakeholder summit, and the 2014 Maryland State Fair. Measurements are done through stakeholder engagement and deidentified survey. Stakeholders evaluated and prioritized evidence from an environmental scan. A surgeon, family member, and palliative care physician team iteratively developed a script featuring 12 core themes and worked with a medical graphic designer to translate the script into storyboards. For 10 days, 359 attendees of the 2014 Maryland State Fair evaluated the storyboards and 87% noted that they would be "very comfortable" or "comfortable" seeing the storyboard before major surgery, 89% considered the storyboards "very helpful" or "helpful," and 89% would "definitely recommend" or "recommend" this story to others preparing for major surgery. Through an iterative process utilizing diverse PCOR engagement methods and informed by SLT, storyboards were developed for an ACP video. Field testing revealed the storyline to be highly meaningful for surgery patients and family members.

Technical note: Application of geophysical tools for tree root studies in forest ecosystems in complex soils

NASA Astrophysics Data System (ADS)

Rodríguez-Robles, Ulises; Arredondo, Tulio; Huber-Sannwald, Elisabeth; Alfredo Ramos-Leal, José; Yépez, Enrico A.

2017-11-01

While semiarid forests frequently colonize rocky substrates, knowledge is scarce on how roots garner resources in these extreme habitats. The Sierra San Miguelito Volcanic Complex in central Mexico exhibits shallow soils and impermeable rhyolitic-rock outcrops, which impede water movement and root placement beyond the soil matrix. However, rock fractures, exfoliated rocks and soil pockets potentially permit downward water percolation and root growth. With ground-penetrating radar (GPR) and electrical resistivity tomography (ERT), two geophysical methods advocated by Jayawickreme et al. (2014) to advance root ecology, we advanced in the method development studying root and water distribution in shallow rocky soils and rock fractures in a semiarid forest. We calibrated geophysical images with in situ root measurements, and then extrapolated root distribution over larger areas. Using GPR shielded antennas, we identified both fine and coarse pine and oak roots from 0.6 to 7.5 cm diameter at different depths into either soil or rock fractures. We also detected, trees anchoring their trunks using coarse roots underneath rock outcroppings. With ERT, we tracked monthly changes in humidity at the soil-bedrock interface, which clearly explained spatial root distribution of both tree species. Geophysical methods have enormous potential in elucidating root ecology. More interdisciplinary research could advance our understanding in belowground ecological niche functions and their role in forest ecohydrology and productivity.

A Natural Language Processing System That Links Medical Terms in Electronic Health Record Notes to Lay Definitions: System Development Using Physician Reviews

PubMed Central

Druhl, Emily; Polepalli Ramesh, Balaji; Houston, Thomas K; Brandt, Cynthia A; Zulman, Donna M; Vimalananda, Varsha G; Malkani, Samir; Yu, Hong

2018-01-01

Background Many health care systems now allow patients to access their electronic health record (EHR) notes online through patient portals. Medical jargon in EHR notes can confuse patients, which may interfere with potential benefits of patient access to EHR notes. Objective The aim of this study was to develop and evaluate the usability and content quality of NoteAid, a Web-based natural language processing system that links medical terms in EHR notes to lay definitions, that is, definitions easily understood by lay people. Methods NoteAid incorporates two core components: CoDeMed, a lexical resource of lay definitions for medical terms, and MedLink, a computational unit that links medical terms to lay definitions. We developed innovative computational methods, including an adapted distant supervision algorithm to prioritize medical terms important for EHR comprehension to facilitate the effort of building CoDeMed. Ten physician domain experts evaluated the user interface and content quality of NoteAid. The evaluation protocol included a cognitive walkthrough session and a postsession questionnaire. Physician feedback sessions were audio-recorded. We used standard content analysis methods to analyze qualitative data from these sessions. Results Physician feedback was mixed. Positive feedback on NoteAid included (1) Easy to use, (2) Good visual display, (3) Satisfactory system speed, and (4) Adequate lay definitions. Opportunities for improvement arising from evaluation sessions and feedback included (1) improving the display of definitions for partially matched terms, (2) including more medical terms in CoDeMed, (3) improving the handling of terms whose definitions vary depending on different contexts, and (4) standardizing the scope of definitions for medicines. On the basis of these results, we have improved NoteAid’s user interface and a number of definitions, and added 4502 more definitions in CoDeMed. Conclusions Physician evaluation yielded useful feedback for content validation and refinement of this innovative tool that has the potential to improve patient EHR comprehension and experience using patient portals. Future ongoing work will develop algorithms to handle ambiguous medical terms and test and evaluate NoteAid with patients. PMID:29358159

Mother-infant circadian rhythm: development of individual patterns and dyadic synchrony.

PubMed

Thomas, Karen A; Burr, Robert L; Spieker, Susan; Lee, Jungeun; Chen, Jessica

2014-12-01

Mutual circadian rhythm is an early and essential component in the development of maternal-infant physiological synchrony. The aim of this to examine the longitudinal pattern of maternal-infant circadian rhythm and rhythm synchrony as measured by rhythm parameters. In-home dyadic actigraphy monitoring at infant age 4, 8, and 12 weeks. Forty-three healthy mother-infant pairs. Circadian parameters derived from cosinor and non-parametric analysis including mesor, magnitude, acrophase, L5 and M10 midpoints (midpoint of lowest 5 and highest 10h of activity), amplitude, interdaily stability (IS), and intradaily variability (IV). Mothers experienced early disruption of circadian rhythm, with re-establishment of rhythm over time. Significant time effects were noted in increasing maternal magnitude, amplitude, and IS and decreasing IV (p<.001). Infants demonstrated a developmental trajectory of circadian pattern with significant time effects for increasing mesor, magnitude, amplitude, L5, IS, and IV (p<.001). By 12 weeks, infant phase advancement was evidenced by mean acrophase and M10 midpoint occurring 60 and 43 min (respectively) earlier than at 4 weeks. While maternal acrophase remained consistent over time, infants became increasingly phase advanced relative to mother and mean infant acrophase at 12 weeks occurred 60 min before mother. Mother-infant synchrony was evidenced in increasing correspondence of acrophase at 12 weeks (r=0.704), L5 (r=0.453) and M10 (r=0.479) midpoints. Development of mother-infant synchrony reflects shared elements of circadian rhythm. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Ductal carcinoma in situ of the breast: can biomarkers improve current management?

PubMed

Bartlett, John M S; Nofech-Moses, Sharon; Rakovitch, Eileen

2014-01-01

Screening for invasive cancer has led to a marked increase in the detection of ductal carcinoma in situ (DCIS). DCIS is, if appropriately managed, a low-risk disease which has a small chance of impacting on patient life expectancy. However, despite significant advances in prognostic marker development in invasive breast cancer, there are no validated diagnostic assays to inform treatment choice for women with DCIS. Therefore we are unable to target effective treatment strategies to women at high risk and avoid over-treatment of women at low risk of progression to invasive breast cancer. Paradoxically, one effect of this uncertainty is undertreatment of some women. We review current practice and research in the field to identify key challenges in the management of DCIS. The impact of clinical research, particularly on the over and undertreatment of women with DCIS is assessed. We note slow progress toward development of diagnostic biomarkers and highlight key opportunities to accelerate advances in this area. DCIS is a low-risk disease, its incidence is increasing, and current treatment is effective. However, many women are either over- or undertreated. Despite repeated calls for development of diagnostic biomarkers, progress in this area has been slow, reflecting a relative lack of investment of research effort and funding. Given the low event rate in treated patients and the lateness of recurrences, many previous studies have only limited power to identify independent prognostic and predictive biomarkers. However, the potential for such biomarkers to personalize treatment for DCIS is extremely high.

Mother-Infant Circadian Rhythm: Development of Individual Patterns and Dyadic Synchrony

PubMed Central

Thomas, Karen A.; Burr, Robert L.; Spieker, Susan; Lee, Jungeun; Chen, Jessica

2014-01-01

Background Mutual circadian rhythm is an early and essential component in the development of maternal-infant physiological synchrony. Aims To examine the longitudinal pattern of maternal-infant circadian rhythm and rhythm synchrony as measured by rhythm parameters. Study Design In-home dyadic actigraphy monitoring at infant age 4, 8, and 12 weeks. Subjects Forty-three healthy mother-infant pairs. Outcome Measures Circadian parameters derived from cosinor and non-parametric analysis including mesor, magnitude, acrophase, L5 and M10 midpoints (midpoint of lowest 5 and highest 10 hours of activity), amplitude, interdaily stability (IS), and intradaily variability (IV). Results Mothers experienced early disruption of circadian rhythm, with re-establishment of rhythm over time. Significant time effects were noted in increasing maternal magnitude, amplitude, and IS and decreasing IV (p < .001). Infants demonstrated a developmental trajectory of circadian pattern with significant time effects for increasing mesor, magnitude, amplitude, L5, IS, and IV (p < .001). By 12 weeks, infant phase advancement was evidenced by mean acrophase and M10 midpoint occurring 60 and 43 minutes (respectively) earlier than at 4 weeks. While maternal acrophase remained consistent over time, infants became increasingly phase advanced relative to mother and mean infant acrophase at 12 weeks occurred 60 minutes before mother. Mother-infant synchrony was evidenced in increasing correspondence of acrophase at 12 weeks (r = 0.704), L5 (r = 0.453) and M10 (r = 0.479) midpoints. Conclusions Development of mother-infant synchrony reflects shared elements of circadian rhythm. PMID:25463836

Comparison of the 2008-2011 and 1993-1995 Surges of Bering Glacier, Alaska

NASA Astrophysics Data System (ADS)

Molnia, B. F.; Angeli, K.

2011-12-01

The 1993-1995 surge of Bering Glacier, Earth's largest surging temperate glacier, was intensively studied. A new surge, which began prior to March 9, 2009, was still active in early August 2011. As was the 1993-1995 surge, the current surge is being studied using multiple remote sensing and ground-based methodologies. The wealth of observations available of both surges permit comparisons to be drawn about similarities and differences regarding processes, timing, intensities, and related topics. For more than a year prior to each surge, the intensity of calving and the rate of terminus retreat in Tashalich Arm increased dramatically, approaching 4 m/d in late 2010. This was abruptly followed by a significant terminus advance. In the current surge, maximum advance rates exceeded 19 m/d between March 18 and May 10, 2011. Through July 20, maximum terminus advance approached 3.2 km with velocities above 8 m/d. Similar rates applied in the earlier surge. Each surge has resulted in a rapid and significant advance of the central Bering Lobe's terminus into Vitus Lake. The terminus advance results from the transfer of a substantial volume of ice from the Bagley Ice Valley into the expanding piedmont lobe. In both surges, conspicuous evidence of tens of meters of glacier surface lowering is visible on the south wall of Juniper Island. In the 1993-1995 surge, terminus advance between October 17, 1993 and May 16, 1994 was nearly 7.8 km, an average advance rate of more than 36 m/d. With the current surge, between January 8 and 14, 2011, the terminus advanced a maximum of 125 m, averaging nearly 21 m/d. By July 11, 2011, maximum velocities still approached 15 m per day, with maximum ice displacements of nearly 2 km and a maximum terminus advance of 1.7 km. In the 1993-1995 surge, the first evidence of surge activity was observed in April 1993, the development of a fractured ice bulge on the northwest side of the Grindle Hills. The surge front reached Bering's terminus at the end of August 1993 and left it heavily fractured. With the current surge, until July 2009, surface displacements were restricted to the area from west of, to northeast of the Grindle Hills. By November 18, 2010, the surge front reached Bering's terminus and left it more heavily fractured than in 1993. The current surge shows the same style and types of surface disruptions and deformations at the same locations as did the earlier surge. For example, in both surges, sinusoidal crevasses were first noted north of the Grindle Hills, while rifts were noted in the upper central piedmont lobe. The current surge has produced much more fracturing of the Medial Moraine Band than did the 1993-95 surge. Similarly, the extent of surface fracturing up-glacier from the piedmont lobe is significantly greater in the current surge. During the 1993-95 surge, surface expression of the surge extended about 45 km east of the western end of Juniper Island. In late July 2011, surge-related surface fractures extended nearly 90 km to the east. The Steller lobe of the Bering Glacier System has not been involved in either surge. Continued observations of the current surge, in the context of the 1993-95 surge, are providing significant insights into repeatable patterns of surging glacier behavior. Bering Glacier is an amazing natural laboratory at which to conduct these observations.

Extremity War Injuries VIII: sequelae of combat injuries.

PubMed

Andersen, Romney C; D'Alleyrand, Jean-Claude G; Swiontkowski, Marc F; Ficke, James R

2014-01-01

The 2013 Extremity War Injury symposium focused on the sequelae of combat-related injuries, including posttraumatic osteoarthritis, amputations, and infections. Much remains to be learned about posttraumatic arthritis, and there are few circumstances in which a definitive arthroplasty should be performed in an acutely injured and open joint. Although the last decade has seen tremendous advances in the treatment of combat upper extremity injuries, many questions remain unanswered, and continued research focusing on improving reconstruction of large segmental defects remains critical. Discussion of infection centered on the need for novel methods to reduce the bacterial load following the initial débridement procedures. Novel methods of delivering antimicrobial therapy and anti-inflammatory medications directly to the wound were discussed as well as the need for near real-time assessment of bacterial and fungal burden and further means of prevention and treatment of biofilm formation and the importance of animal models to test therapies discussed. Moderators and lecturers of focus groups noted the continuing need for improved prehospital care in the management of junctional injuries, identified optimal strategies for both surgical repair and/or reconstruction of the ligaments in multiligamentous injuries, and noted the need to mitigate bone mineral density loss following amputation and/or limb salvage as well as the necessity of developing better methods of anticipating and managing heterotopic ossification.

Carbon Dioxide Removal and the futures market

NASA Astrophysics Data System (ADS)

Lockley, A.; Coffman, D.

2016-12-01

Futures contracts are exchange-traded financial instruments that enable parties to fix a price in advance, for performance on a contract at some later date. Forward contracts also entail future settlement, but they are traded over-the-counter between two independent parties. Both futures and forward contracts are commonly used in commodities trading, as producers seek financial security when planning production. We discuss the use of potential use of exchange-traded futures contracts in Carbon Dioxide Removal (CDR) markets. We conclude that they have one principal advantage (in that they give near-term price security to current polluters), and one principal disadvantage (in that a combination of high price volatility and high trade volume means contracts issued by the private sector may cause systemic economic risk). Accordingly, we note the potential for the development of futures markets in CDR, but urge great caution in the use of this approach. In particular, we consider the use of regulated markets: to ensure contracts are more reliable, and that moral hazard is minimised. Whilst regulation offers generally increased assurances, we identify major insufficiencies with this approach - finding it generally inadequate. In conclusion, we suggest that only governments can realistically support long-term CDR futures markets. We note existing long-term CDR plans by governments, and suggest the use of state-backed futures for supporting these assurances.

Finding Important Terms for Patients in Their Electronic Health Records: A Learning-to-Rank Approach Using Expert Annotations

PubMed Central

Zheng, Jiaping; Yu, Hong

2016-01-01

Background Many health organizations allow patients to access their own electronic health record (EHR) notes through online patient portals as a way to enhance patient-centered care. However, EHR notes are typically long and contain abundant medical jargon that can be difficult for patients to understand. In addition, many medical terms in patients’ notes are not directly related to their health care needs. One way to help patients better comprehend their own notes is to reduce information overload and help them focus on medical terms that matter most to them. Interventions can then be developed by giving them targeted education to improve their EHR comprehension and the quality of care. Objective We aimed to develop a supervised natural language processing (NLP) system called Finding impOrtant medical Concepts most Useful to patientS (FOCUS) that automatically identifies and ranks medical terms in EHR notes based on their importance to the patients. Methods First, we built an expert-annotated corpus. For each EHR note, 2 physicians independently identified medical terms important to the patient. Using the physicians’ agreement as the gold standard, we developed and evaluated FOCUS. FOCUS first identifies candidate terms from each EHR note using MetaMap and then ranks the terms using a support vector machine-based learn-to-rank algorithm. We explored rich learning features, including distributed word representation, Unified Medical Language System semantic type, topic features, and features derived from consumer health vocabulary. We compared FOCUS with 2 strong baseline NLP systems. Results Physicians annotated 90 EHR notes and identified a mean of 9 (SD 5) important terms per note. The Cohen’s kappa annotation agreement was .51. The 10-fold cross-validation results show that FOCUS achieved an area under the receiver operating characteristic curve (AUC-ROC) of 0.940 for ranking candidate terms from EHR notes to identify important terms. When including term identification, the performance of FOCUS for identifying important terms from EHR notes was 0.866 AUC-ROC. Both performance scores significantly exceeded the corresponding baseline system scores (P<.001). Rich learning features contributed to FOCUS’s performance substantially. Conclusions FOCUS can automatically rank terms from EHR notes based on their importance to patients. It may help develop future interventions that improve quality of care. PMID:27903489

Finding Important Terms for Patients in Their Electronic Health Records: A Learning-to-Rank Approach Using Expert Annotations.

PubMed

Chen, Jinying; Zheng, Jiaping; Yu, Hong

2016-11-30

Many health organizations allow patients to access their own electronic health record (EHR) notes through online patient portals as a way to enhance patient-centered care. However, EHR notes are typically long and contain abundant medical jargon that can be difficult for patients to understand. In addition, many medical terms in patients' notes are not directly related to their health care needs. One way to help patients better comprehend their own notes is to reduce information overload and help them focus on medical terms that matter most to them. Interventions can then be developed by giving them targeted education to improve their EHR comprehension and the quality of care. We aimed to develop a supervised natural language processing (NLP) system called Finding impOrtant medical Concepts most Useful to patientS (FOCUS) that automatically identifies and ranks medical terms in EHR notes based on their importance to the patients. First, we built an expert-annotated corpus. For each EHR note, 2 physicians independently identified medical terms important to the patient. Using the physicians' agreement as the gold standard, we developed and evaluated FOCUS. FOCUS first identifies candidate terms from each EHR note using MetaMap and then ranks the terms using a support vector machine-based learn-to-rank algorithm. We explored rich learning features, including distributed word representation, Unified Medical Language System semantic type, topic features, and features derived from consumer health vocabulary. We compared FOCUS with 2 strong baseline NLP systems. Physicians annotated 90 EHR notes and identified a mean of 9 (SD 5) important terms per note. The Cohen's kappa annotation agreement was .51. The 10-fold cross-validation results show that FOCUS achieved an area under the receiver operating characteristic curve (AUC-ROC) of 0.940 for ranking candidate terms from EHR notes to identify important terms. When including term identification, the performance of FOCUS for identifying important terms from EHR notes was 0.866 AUC-ROC. Both performance scores significantly exceeded the corresponding baseline system scores (P<.001). Rich learning features contributed to FOCUS's performance substantially. FOCUS can automatically rank terms from EHR notes based on their importance to patients. It may help develop future interventions that improve quality of care. ©Jinying Chen, Jiaping Zheng, Hong Yu. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 30.11.2016.

Development and evaluation of 'briefing notes' as a novel knowledge translation tool to aid the implementation of sex/gender analysis in systematic reviews: a pilot study.

PubMed

Doull, Marion; Welch, Vivian; Puil, Lorri; Runnels, Vivien; Coen, Stephanie E; Shea, Beverley; O'Neill, Jennifer; Borkhoff, Cornelia; Tudiver, Sari; Boscoe, Madeline

2014-01-01

There is increasing recognition of sex/gender differences in health and the importance of identifying differential effects of interventions for men and women. Yet, to whom the research evidence does or does not apply, with regard to sex/gender, is often insufficiently answered. This is also true for systematic reviews which synthesize results of primary studies. A lack of analysis and reporting of evidence on sex/gender raises concerns about the applicability of systematic reviews. To bridge this gap, this pilot study aimed to translate knowledge about sex/gender analysis (SGA) into a user-friendly 'briefing note' format and evaluate its potential in aiding the implementation of SGA in systematic reviews. Our Sex/Gender Methods Group used an interactive process to translate knowledge about sex/gender into briefing notes, a concise communication tool used by policy and decision makers. The briefing notes were developed in collaboration with three Cochrane Collaboration review groups (HIV/AIDS, Hypertension, and Musculoskeletal) who were also the target knowledge users of the briefing notes. Briefing note development was informed by existing systematic review checklists, literature on sex/gender, in-person and virtual meetings, and consultation with topic experts. Finally, we held a workshop for potential users to evaluate the notes. Each briefing note provides tailored guidance on considering sex/gender to reviewers who are planning or conducting systematic reviews and includes the rationale for considering sex/gender, with examples specific to each review group's focus. Review authors found that the briefing notes provided welcome guidance on implementing SGA that was clear and concise, but also identified conceptual and implementation challenges. Sex/gender briefing notes are a promising knowledge translation tool. By encouraging sex/gender analysis and equity considerations in systematic reviews, the briefing notes can assist systematic reviewers in ensuring the applicability of research evidence, with the goal of improved health outcomes for diverse populations.

Notes on advanced engineering education

NASA Astrophysics Data System (ADS)

Klimenko, A. Y.

2017-11-01

This article reviews history, analyses principles and presents a modern interpretation of advanced engineering education (AEE). AEE originated in France, was adapted in Germany and reached its zenith in the second half of the twentieth century as part of technological efforts induced by the space race. AEE is an enhanced form of education aimed at producing inventors, thinkers and leaders capable of bringing new technological changes and scientific revolutions. AEE introduces a challenging educational environment that is generally addressed to the most enthusiastic and capable students; it is not necessarily suitable for the mainstream education. The role of AEE is projected to increase as the world becomes a global knowledge society.

Securing the Future of Communication Education: Advancing an Advocacy and Research Agenda for the 21st Century

ERIC Educational Resources Information Center

Hunt, Stephen; Wright, Anna; Simonds, Cheri

2014-01-01

In the late 1980s, noted communication scholar Cassandra Book laid out a comprehensive rationale and agenda for communication education research specifically focusing on pedagogical content knowledge for Communication courses in K-12 education. It has been 25 years since Book published her call for those in our discipline to pursue research…

Review of Aircraft Crash Structural Response Research.

DTIC Science & Technology

1982-08-01

structures consisting of conventional built-up metallic construction and those consisting of advanced composite materials were of interest. The latter...increasing importance. Some recent theoretical and experimental studies of the behavior of composite - material structures subjected to severe static...dynamic, and/or impact conditions are noted. Such topics as crashworthiness testing ot composite fuselage structures, the impact resistance of graphite and

Agroterrorism: Threats and Preparedness

DTIC Science & Technology

2006-08-25

7 Figure 4. Concentration of Chicken Production . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Figure 5. Concentration of Corn Production...million hogs. Farm sales of broilers and other meat-type chickens exceeded 8.5 billion birds.12 Agriculture in the U.S. is technologically advanced...Maryland- Virginia). The top three chicken -producing states (Georgia, Arkansas, and Alabama) produce 41% of U.S. chickens (Figure 4). CRS-7 Note:Catt le

Validating Innovative Renewable Energy Technologies: ESTCP Demonstrations at Two DoD Facilities

DTIC Science & Technology

2012-05-01

AND SUBTITLE Validating Innovative Renewable Energy Technologies: ESTCP Demonstrations at Two DoD Facilities 5a. CONTRACT NUMBER 5b. GRANT NUMBER...Southern Research Institute,Advanced Energy Department,2000 Ninth Avenue South,Birmingham,AL,35205-5305 8. PERFORMING ORGANIZATION REPORT NUMBER...AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES Presented at the NDIA Environment, Energy Security

Non-Formal Education in Poland and Canada--Compared: A Brief Commentary

ERIC Educational Resources Information Center

Butler, Norman L.; Griffith, Kimberly Grantham; Kritsonis, William Allan

2007-01-01

The purpose of this brief note is to compare non-formal education in Poland and Canada in terms of accessibility, and it is motivated by the fact that learning is a lifelong process because of rapid advances in technology. The theoretical framework for this commentary is supplied by the general idea that non-formal learning provides a social…

To amend the Oil Pollution Act of 1990 to authorize advances from Oil Spill Liability Trust Fund for the Deepwater Horizon oil spill.

THOMAS, 111th Congress

Rep. Mica, John L. [R-FL-7

2010-06-10

House - 06/11/2010 Referred to the Subcommittee on Water Resources and Environment. (All Actions) Notes: For further action, see S.3473, which became Public Law 111-191 on 6/15/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

Why Do Scholars Use Powerpoint the Way They Do?

ERIC Educational Resources Information Center

Hertz, Brigitte; van Woerkum, Cees; Kerkhof, Peter

2015-01-01

PowerPoint has received much criticism regarding excessive use of text and the lack of contact with the audience. Why presenters use PowerPoint in this way has not been studied so far. Our study using interviews with beginning and advanced presenters shows that some use the program as a speaking note and as a means to draw the attention away from…

Advanced Placement® Statistics Students' Education Choices after High School. Research Notes. RN-38

ERIC Educational Resources Information Center

Patterson, Brian F.

2009-01-01

Taking the AP Statistics course and exam does not appear to be related to greater interest in the statistical sciences. Despite this finding, with respect to deciding whether to take further statistics course work and majoring in statistics, students appear to feel prepared for, but not interested in, further study. There is certainly more…

Differences in the Processes of Solving Physics Problems between Good Physics Problem Solvers and Poor Physics Problem Solvers.

ERIC Educational Resources Information Center

Finegold, M.; Mass, R.

1985-01-01

Good problem solvers and poor problem solvers in advanced physics (N=8) were significantly different in their ability in translating, planning, and physical reasoning, as well as in problem solving time; no differences in reliance on algebraic solutions and checking problems were noted. Implications for physics teaching are discussed. (DH)

Addressing Achievement Gaps: Advancing Learning for Our Diverse Adult Population. Policy Notes. Volume 18, Number 2, Spring 2010

ERIC Educational Resources Information Center

Yaffe, Deborah

2010-01-01

Decades ago, most U.S. companies hired locally, few jobs required a college education and even high school dropouts could find well-paying work. However, the world has changed. With automation and overseas outsourcing eliminating many low-skilled jobs--and, increasingly, many higher-skilled ones--more and more Americans need postsecondary…

Career Notes: Explore and Practice Personal Career Growth Skills. CHOICE (Challenging Options in Career Education).

ERIC Educational Resources Information Center

Gans, Connie; And Others

This text is the second in a series of advanced career education materials which, with an elementary segment, form a career education curriculum for elementary-secondary migrant students. Complementing texts on careers and roles and on work exploration and work experience, the text uses activities, poems, and cartoons to focus on self-awareness…

Using Artificial Physics to Control Agents

DTIC Science & Technology

1999-11-01

unlimited 13. SUPPLEMENTARY NOTES IEEE International Conference on Information, Intelligence, and Systems, Oct 31 -Nov 3,1999. Bethesda, MD 14. ABSTRACT...distributed control can also perform distributed computation. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT Same...1995. [9] H. Pattee. Artificial life needs a real epistemology. In Moran, Moreno, Merelo, and Chacon , editors, Advances in Artificial Life, pages

Addressing Achievement Gaps: The Language Acquisition and Educational Achievement of English-Language Learners. ETS Policy Notes. Volume 16, Number 2, Summer 2008

ERIC Educational Resources Information Center

McBride, Amanda

2008-01-01

The eighth "ETS Addressing Achievement Gaps Symposium" provided a public forum for educators, policymakers, and researchers to forge productive relationships that will advance their efforts to enhance the educational achievement of America's five million English-language learners (ELLs). The conference was held at ETS world headquarters in…

A Broader Education for Special Forces Officers

DTIC Science & Technology

2011-05-19

education professionals. Arthur Cropley , Professor of Educational Psychology at the University of Hamburg, notes that lifelong learning would: 2. lead...Arthur Cropley , “Lifelong Learning and Systems of Education: an Overview”, in A Cropley , ed. Towards a System of Lifelong Education: Some Practical...Leavenworth, KS: School of Advanced Military Studies, United States Army Command and General Staff College, 2008. 46 Cropley ,Arthur. “Lifelong

Advanced Configurations for Very Large Subsonic Transport Airplanes

NASA Technical Reports Server (NTRS)

McMasters, John H.; Paisley, David J.; Hubert, Richard J.; Kroo, Ilan; Bofah, Kwasi K.; Sullivan, John P.; Drela, Mark

1996-01-01

Recent aerospace industry interest in developing a subsonic commercial transport airplane with 50 percent greater passenger capacity than the largest existing aircraft in this category (the Boeing 747-400 with approximately 400-450 seats) has generated a range of proposals based largely on the configuration paradigm established nearly 50 years ago with the Boeing B-47 bomber. While this basic configuration paradigm has come to dominate subsonic commercial airplane development since the advent of the Boeing 707/Douglas DC-8 in the mid-1950's, its extrapolation to the size required to carry more than 600-700 passengers raises several questions. To explore these and a number of related issues, a team of Boeing, university, and NASA engineers was formed under the auspices of the NASA Advanced Concepts Program. The results of a Research Analysis focused on a large, unconventional transport airplane configuration for which Boeing has applied for a patent are the subject of this report. It should be noted here that this study has been conducted independently of the Boeing New Large Airplane (NLA) program, and with the exception of some generic analysis tools which may be common to this effort and the NLA (as will be described later), no explicit Boeing NLA data other than that published in the open literature has been used in the conduct of the study reported here.

Deep learning for healthcare: review, opportunities and challenges.

PubMed

Miotto, Riccardo; Wang, Fei; Wang, Shuang; Jiang, Xiaoqian; Dudley, Joel T

2017-05-06

Gaining knowledge and actionable insights from complex, high-dimensional and heterogeneous biomedical data remains a key challenge in transforming health care. Various types of data have been emerging in modern biomedical research, including electronic health records, imaging, -omics, sensor data and text, which are complex, heterogeneous, poorly annotated and generally unstructured. Traditional data mining and statistical learning approaches typically need to first perform feature engineering to obtain effective and more robust features from those data, and then build prediction or clustering models on top of them. There are lots of challenges on both steps in a scenario of complicated data and lacking of sufficient domain knowledge. The latest advances in deep learning technologies provide new effective paradigms to obtain end-to-end learning models from complex data. In this article, we review the recent literature on applying deep learning technologies to advance the health care domain. Based on the analyzed work, we suggest that deep learning approaches could be the vehicle for translating big biomedical data into improved human health. However, we also note limitations and needs for improved methods development and applications, especially in terms of ease-of-understanding for domain experts and citizen scientists. We discuss such challenges and suggest developing holistic and meaningful interpretable architectures to bridge deep learning models and human interpretability. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Induced pluripotent stem cells (iPSC)-derived retinal cells in disease modeling and regenerative medicine.

PubMed

Rathod, Reena; Surendran, Harshini; Battu, Rajani; Desai, Jogin; Pal, Rajarshi

2018-02-12

Retinal degenerative disorders are a leading cause of the inherited, irreversible and incurable vision loss. While various rodent model systems have provided crucial information in this direction, lack of disease-relevant tissue availability and species-specific differences have proven to be a major roadblock. Human induced pluripotent stem cells (iPSC) have opened up a whole new avenue of possibilities not just in understanding the disease mechanism but also potential therapeutic approaches towards a cure. In this review, we have summarized recent advances in the methods of deriving retinal cell types from iPSCs which can serve as a renewable source of disease-relevant cell population for basic as well as translational studies. We also provide an overview of the ongoing efforts towards developing a suitable in vitro model for modeling retinal degenerative diseases. This basic understanding in turn has contributed to advances in translational goals such as drug screening and cell-replacement therapies. Furthermore we discuss gene editing approaches for autologous repair of genetic disorders and allogeneic transplantation of stem cell-based retinal derivatives for degenerative disorders with an ultimate goal to restore vision. It is pertinent to note however, that these exciting new developments throw up several challenges that need to be overcome before their full clinical potential can be realized. Copyright © 2018 Elsevier B.V. All rights reserved.

Use of Savitzky-Golay Filter for Performances Improvement of SHM Systems Based on Neural Networks and Distributed PZT Sensors.

PubMed

de Oliveira, Mario A; Araujo, Nelcileno V S; da Silva, Rodolfo N; da Silva, Tony I; Epaarachchi, Jayantha

2018-01-08

A considerable amount of research has focused on monitoring structural damage using Structural Health Monitoring (SHM) technologies, which has had recent advances. However, it is important to note the challenges and unresolved problems that disqualify currently developed monitoring systems. One of the frontline SHM technologies, the Electromechanical Impedance (EMI) technique, has shown its potential to overcome remaining problems and challenges. Unfortunately, the recently developed neural network algorithms have not shown significant improvements in the accuracy of rate and the required processing time. In order to fill this gap in advanced neural networks used with EMI techniques, this paper proposes an enhanced and reliable strategy for improving the structural damage detection via: (1) Savitzky-Golay (SG) filter, using both first and second derivatives; (2) Probabilistic Neural Network (PNN); and, (3) Simplified Fuzzy ARTMAP Network (SFAN). Those three methods were employed to analyze the EMI data experimentally obtained from an aluminum plate containing three attached PZT (Lead Zirconate Titanate) patches. In this present study, the damage scenarios were simulated by attaching a small metallic nut at three different positions in the aluminum plate. We found that the proposed method achieves a hit rate of more than 83%, which is significantly higher than current state-of-the-art approaches. Furthermore, this approach results in an improvement of 93% when considering the best case scenario.

Use of Savitzky–Golay Filter for Performances Improvement of SHM Systems Based on Neural Networks and Distributed PZT Sensors

PubMed Central

Araujo, Nelcileno V. S.; da Silva, Rodolfo N.; da Silva, Tony I.; Epaarachchi, Jayantha

2018-01-01

A considerable amount of research has focused on monitoring structural damage using Structural Health Monitoring (SHM) technologies, which has had recent advances. However, it is important to note the challenges and unresolved problems that disqualify currently developed monitoring systems. One of the frontline SHM technologies, the Electromechanical Impedance (EMI) technique, has shown its potential to overcome remaining problems and challenges. Unfortunately, the recently developed neural network algorithms have not shown significant improvements in the accuracy of rate and the required processing time. In order to fill this gap in advanced neural networks used with EMI techniques, this paper proposes an enhanced and reliable strategy for improving the structural damage detection via: (1) Savitzky–Golay (SG) filter, using both first and second derivatives; (2) Probabilistic Neural Network (PNN); and, (3) Simplified Fuzzy ARTMAP Network (SFAN). Those three methods were employed to analyze the EMI data experimentally obtained from an aluminum plate containing three attached PZT (Lead Zirconate Titanate) patches. In this present study, the damage scenarios were simulated by attaching a small metallic nut at three different positions in the aluminum plate. We found that the proposed method achieves a hit rate of more than 83%, which is significantly higher than current state-of-the-art approaches. Furthermore, this approach results in an improvement of 93% when considering the best case scenario. PMID:29316693

Precision Medicine Approach to Anaplastic Thyroid Cancer: Advances in Targeted Drug Therapy Based on Specific Signaling Pathways.

PubMed

Samimi, Hilda; Fallah, Parviz; Naderi Sohi, Alireza; Tavakoli, Rezvan; Naderi, Mahmood; Soleimani, Masoud; Larijani, Bagher; Haghpanah, Vahid

2017-03-01

Personalized medicine is a set of diagnostic, prognostic and therapeutic approaches in which medical interventions are carried out based on individual patient characteristics. As life expectancy increases in developed and developing countries, the incidence of diseases such as cancer goes up among people in the community. Cancer is a disease that the response to treatment varies from one person to another and also it is costly for individuals, families, and society. Among thyroid cancers, anaplastic thyroid carcinoma (ATC) is the most aggressive, lethal and unresponsive form of the disease. Unfortunately, current drugs are not targetable, and therefore they have restricted role in ATC treatment. Consequently, mortality of this cancer, despite advances in the field of diagnosis and treatment, is one of the most important challenges in medicine. Cellular, molecular and genetic evidences play an important role in finding more effective diagnostic and therapeutic approaches. Review of these evidences confirms the application of personalized medicine in cancer treatment including ATC. A growing body of evidence has elucidated that cellular and molecular mechanisms of cancer would pave the way for defining new biomarkers for targeted therapy, taking into account individual differences. It should be noted that this approach requires further progress in the fields of basic sciences, pharmacogenetics and drug design. An overview of the most important aspects in individualized anaplastic thyroid cancer treatment will be discussed in this review.

NOTES: a review of the technical problems encountered and their solutions.

PubMed

Mintz, Yoav; Horgan, Santiago; Cullen, John; Stuart, David; Falor, Eric; Talamini, Mark A

2008-08-01

Natural orifice translumenal endoscopic surgery (NOTES) is currently investigated and developed worldwide. In the past few years, multiple groups have confronted this challenge. Many technical problems are encountered in this technique due to the currently available tools for this approach. Some of the unique technical problems in NOTES include: blindly performed primary incisions; uncontrolled pneumoperitoneal pressure; no support for the endoscope in the abdominal cavity; inadequate vision; insufficient illumination; limited retraction and exposure; and the complexity of suturing and performing a safe anastomosis. In this paper, we review the problems encountered in NOTES and provide possible temporary solutions. Acute and survival studies were performed on 15 farm pigs. The hybrid technique approach (i.e., endoscopic surgery with the aid of laparoscopic vision) was performed in all cases. Procedures performed included liver biopsies, bilateral tubal ligation, oophprectomy, cholecystectomy, splenectomy and small bowel resection, and anastomosis. All attempted procedures were successfully performed. New methods and techniques were developed to overcome the technical problems. Closure of the gastrotomy was achieved by T-bar sutures and by stapler closure of the stomach incision. Small bowel anastomosis was achieved by the dual-lumen NOTES technique. The hybrid technique serves as a temporary approach to aid in developing the NOTES technique. A rectal or vaginal port of entry enables and facilitates gastrointestinal NOTES by using available laparoscopic instruments. The common operations performed today in the laparoscopic fashion could be probably performed in the NOTES approach. The safety of these procedures, however, is yet to be determined.

Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy.

PubMed

Liu, Vincent Wing Sun; Yau, Wing Lung; Tam, Chun Wai; Yao, Kwok-Ming; Shiu, Stephen Yuen Wing

2017-05-31

A major current challenge in the treatment of advanced prostate cancer, which can be initially controlled by medical or surgical castration, is the development of effective, safe, and affordable therapies against progression of the disease to the stage of castration resistance. Here, we showed that in LNCaP and 22Rv1 prostate cancer cells transiently overexpressing androgen receptor splice variant-7 (AR-V7), nuclear factor-kappa B (NF-κB) was activated and could result in up-regulated interleukin ( IL ) -6 gene expression, indicating a positive interaction between AR-V7 expression and activated NF-κB/IL-6 signaling in castration-resistant prostate cancer (CRPC) pathogenesis. Importantly, both AR-V7-induced NF-κB activation and IL-6 gene transcription in LNCaP and 22Rv1 cells could be inhibited by melatonin. Furthermore, stimulation of AR-V7 mRNA expression in LNCaP cells by betulinic acid, a pharmacological NF-κB activator, was reduced by melatonin treatment. Our data support the presence of bi-directional positive interactions between AR-V7 expression and NF-κB activation in CRPC pathogenesis. Of note, melatonin, by inhibiting NF-κB activation via the previously-reported MT₁ receptor-mediated antiproliferative pathway, can disrupt these bi-directional positive interactions between AR-V7 and NF-κB and thereby delay the development of castration resistance in advanced prostate cancer. Apparently, this therapeutic potential of melatonin in advanced prostate cancer/CRPC management is worth translation in the clinic via combined androgen depletion and melatonin repletion.

Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy

PubMed Central

Liu, Vincent Wing Sun; Yau, Wing Lung; Tam, Chun Wai; Yao, Kwok-Ming; Shiu, Stephen Yuen Wing

2017-01-01

A major current challenge in the treatment of advanced prostate cancer, which can be initially controlled by medical or surgical castration, is the development of effective, safe, and affordable therapies against progression of the disease to the stage of castration resistance. Here, we showed that in LNCaP and 22Rv1 prostate cancer cells transiently overexpressing androgen receptor splice variant-7 (AR-V7), nuclear factor-kappa B (NF-κB) was activated and could result in up-regulated interleukin (IL)-6 gene expression, indicating a positive interaction between AR-V7 expression and activated NF-κB/IL-6 signaling in castration-resistant prostate cancer (CRPC) pathogenesis. Importantly, both AR-V7-induced NF-κB activation and IL-6 gene transcription in LNCaP and 22Rv1 cells could be inhibited by melatonin. Furthermore, stimulation of AR-V7 mRNA expression in LNCaP cells by betulinic acid, a pharmacological NF-κB activator, was reduced by melatonin treatment. Our data support the presence of bi-directional positive interactions between AR-V7 expression and NF-κB activation in CRPC pathogenesis. Of note, melatonin, by inhibiting NF-κB activation via the previously-reported MT1 receptor-mediated antiproliferative pathway, can disrupt these bi-directional positive interactions between AR-V7 and NF-κB and thereby delay the development of castration resistance in advanced prostate cancer. Apparently, this therapeutic potential of melatonin in advanced prostate cancer/CRPC management is worth translation in the clinic via combined androgen depletion and melatonin repletion. PMID:28561752

Integrated planning and scheduling for Earth science data processing

NASA Technical Reports Server (NTRS)

Boddy, Mark; White, Jim; Goldman, Robert; Short, Nick, Jr.

1995-01-01

Several current NASA programs such as the EOSDIS Core System (ECS) have data processing and data management requirements that call for an integrated planning and scheduling capability. In this paper, we describe the experience of applying advanced scheduling technology operationally, in terms of what was accomplished, lessons learned, and what remains to be done in order to achieve similar successes in ECS and other programs. We discuss the importance and benefits of advanced scheduling tools, and our progress toward realizing them, through examples and illustrations based on ECS requirements. The first part of the paper focuses on the Data Archive and Distribution (DADS) V0 Scheduler. We then discuss system integration issues ranging from communication with the scheduler to the monitoring of system events and re-scheduling in response to them. The challenge of adapting the scheduler to domain-specific features and scheduling policies is also considered. Extrapolation to the ECS domain raises issues of integrating scheduling with a product-generation planner (such as PlaSTiC), and implementing conditional planning in an operational system. We conclude by briefly noting ongoing technology development and deployment projects being undertaken by HTC and the ISTB.

Differentiating Science Instruction: Secondary science teachers' practices

NASA Astrophysics Data System (ADS)

Maeng, Jennifer L.; Bell, Randy L.

2015-09-01

This descriptive study investigated the implementation practices of secondary science teachers who differentiate instruction. Participants included seven high school science teachers purposefully selected from four different schools located in a mid-Atlantic state. Purposeful selection ensured participants included differentiated instruction (DI) in their lesson implementation. Data included semi-structured interviews and field notes from a minimum of four classroom observations, selected to capture the variety of differentiation strategies employed. These data were analyzed using a constant-comparative approach. Each classroom observation was scored using the validated Differentiated Instruction Implementation Matrix-Modified, which captured both the extent to which critical indicators of DI were present in teachers' instruction and the performance levels at which they engaged in these components of DI. Results indicated participants implemented a variety of differentiation strategies in their classrooms with varying proficiency. Evidence suggested all participants used instructional modifications that required little advance preparation to accommodate differences in students' interests and learning profile. Four of the seven participants implemented more complex instructional strategies that required substantial advance preparation by the teacher. Most significantly, this study provides practical strategies for in-service science teachers beginning to differentiate instruction and recommendations for professional development and preservice science teacher education.

Emerging Prototype Sodium-Ion Full Cells with Nanostructured Electrode Materials.

PubMed

Ren, Wenhao; Zhu, Zixuan; An, Qinyou; Mai, Liqiang

2017-06-01

Due to steadily increasing energy consumption, the demand of renewable energy sources is more urgent than ever. Sodium-ion batteries (SIBs) have emerged as a cost-effective alternative because of the earth abundance of Na resources and their competitive electrochemical behaviors. Before practical application, it is essential to establish a bridge between the sodium half-cell and the commercial battery from a full cell perspective. An overview of the major challenges, most recent advances, and outlooks of non-aqueous and aqueous sodium-ion full cells (SIFCs) is presented. Considering the intimate relationship between SIFCs and electrode materials, including structure, composition and mutual matching principle, both the advance of various prototype SIFCs and the electrochemistry development of nanostructured electrode materials are reviewed. It is noted that a series of SIFCs combined with layered oxides and hard carbon are capable of providing a high specific gravimetric energy above 200 Wh kg -1 , and an NaCrO 2 //hard carbon full cell is able to deliver a high rate capability over 100 C. To achieve industrialization of SIBs, more systematic work should focus on electrode construction, component compatibility, and battery technologies. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Nanotechnology applications in thoracic surgery

PubMed Central

Hofferberth, Sophie C.; Grinstaff, Mark W.; Colson, Yolonda L.

2016-01-01

Nanotechnology is an emerging, rapidly evolving field with the potential to significantly impact care across the full spectrum of cancer therapy. Of note, several recent nanotechnological advances show particular promise to improve outcomes for thoracic surgical patients. A variety of nanotechnologies are described that offer possible solutions to existing challenges encountered in the detection, diagnosis and treatment of lung cancer. Nanotechnology-based imaging platforms have the ability to improve the surgical care of patients with thoracic malignancies through technological advances in intraoperative tumour localization, lymph node mapping and accuracy of tumour resection. Moreover, nanotechnology is poised to revolutionize adjuvant lung cancer therapy. Common chemotherapeutic drugs, such as paclitaxel, docetaxel and doxorubicin, are being formulated using various nanotechnologies to improve drug delivery, whereas nanoparticle (NP)-based imaging technologies can monitor the tumour microenvironment and facilitate molecularly targeted lung cancer therapy. Although early nanotechnology-based delivery systems show promise, the next frontier in lung cancer therapy is the development of ‘theranostic’ multifunctional NPs capable of integrating diagnosis, drug monitoring, tumour targeting and controlled drug release into various unifying platforms. This article provides an overview of key existing and emerging nanotechnology platforms that may find clinical application in thoracic surgery in the near future. PMID:26843431

[Psychoanalysis in the advanced vocational training of social workers, Berlin 1930-1933 (Verein Jugendheim)].

PubMed

Schröter, Michael

2005-01-01

The Verein Jugendheim in Berlin-Charlottenburg was a holding organisation of welfare institutions and of training facilities for members of the caring professions. In 1928 it founded a Soziales Institute that offered various courses for advanced vocational training. In those courses depth psychology - mainly represented by the Adlerians, least by the Jungians and increasingly by the Freudians - had a prominent place. The role of the Freudian school was supported by the fact that two staff members of the Jugendheim (Hildegard Buder-Schenck, Ursula Graf [Laessig]) started their analytic training at that time. The main teachers of psychoanalysis at the Institute were Siegfried Bernfeld, Edith Jacobson and Steffi Bornstein; notes take by a student at one of Jacobson's seminars are documented in this paper. In general, in the psychoanalytic courses there seems to have been a shift from academic teaching of theory to case oriented supervision. The presence of psychoanalysis in the training program of the Jugendheim indicates the beginning of an institutional rapprochement between pedagogy or social work and psychoanalysis in Berlin, analogous to earlier developments in Vienna. The rise of the Nazis put a stop to this promising, yet hitherto completely unknown, chapter of history.

Amyotrophic lateral sclerosis: recent genetic highlights.

PubMed

White, Matthew A; Sreedharan, Jemeen

2016-10-01

Amyotrophic lateral sclerosis (ALS), like other neurodegenerative diseases, remains incurable, but gene mutations linked to ALS are providing clues as to how to target therapies. It is important for researchers to keep abreast of the rapid influx of new data in ALS, and we aim to summarize the major genetic advances made in the field over the past 2 years. Significant variation in seven genes has recently been found in ALS: TBK1, CCNF, GLE1, MATR3, TUBA4A, CHCHD10 and NEK1. These have mostly been identified through large exome screening studies, though traditional linkage approaches and candidate gene screening remain important. We briefly update C9orf72 research, noting in particular the development of reagents to better understand the normal role of C9orf72 protein. Striking advances in our understanding of the genetic heterogeneity of ALS continue to be made, year on year. These implicate proteostasis, RNA export, nuclear transport, the cytoskeleton, mitochondrial function, the cell cycle and DNA repair. Functional studies to integrate these hits are needed. By building a web of knowledge with interlinked genes and mechanisms, it is hoped we can better understand ALS and work toward effective therapies.

Aerospace materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dornheim, M.A.

1991-04-01

A comprehensive evaluation is made of the development trends in high performance advanced aerospace structural materials applications. It is noted that the anticipated predominance of thermoplastic composite-matrix polymers in the F-22/F-23 ATF propotypes has not materialized, due both to their high materials and processing costs and the emergence of a more tractable high operating temperature thermoset, BMI, whose toughness characteristics are of the order of those associated with thermoplastics. No more than 15 percent of F-22 weight is thermoplastics; the F-23 use of such resins is nill. Throughout the advanced nonmetallics industry, reduced DOD procurements have come to represent slowmore » growth and the prospect of consolidation. Also, such lightweight Al-based metallics as the Al-Li alloys have posed a major market-share challenge to polymeric composites, as in the case of the C-17 airlifter's 6,269 lbs of such Al-Li alloys as 2090, largely in cargo floor and ramp bulkhead structures. The EFA fighter makes frequent use of SPF-DB Ti alloys in combat damage-critical components. Metal-matrix composites employing titanium aluminide matrices will be extensively used in the X-30 hypersonic aircraft program.« less

Advances in Photopletysmography Signal Analysis for Biomedical Applications.

PubMed

Moraes, Jermana L; Rocha, Matheus X; Vasconcelos, Glauber G; Vasconcelos Filho, José E; de Albuquerque, Victor Hugo C; Alexandria, Auzuir R

2018-06-09

Heart Rate Variability (HRV) is an important tool for the analysis of a patient’s physiological conditions, as well a method aiding the diagnosis of cardiopathies. Photoplethysmography (PPG) is an optical technique applied in the monitoring of the HRV and its adoption has been growing significantly, compared to the most commonly used method in medicine, Electrocardiography (ECG). In this survey, definitions of these technique are presented, the different types of sensors used are explained, and the methods for the study and analysis of the PPG signal (linear and nonlinear methods) are described. Moreover, the progress, and the clinical and practical applicability of the PPG technique in the diagnosis of cardiovascular diseases are evaluated. In addition, the latest technologies utilized in the development of new tools for medical diagnosis are presented, such as Internet of Things, Internet of Health Things, genetic algorithms, artificial intelligence and biosensors which result in personalized advances in e-health and health care. After the study of these technologies, it can be noted that PPG associated with them is an important tool for the diagnosis of some diseases, due to its simplicity, its cost⁻benefit ratio, the easiness of signals acquisition, and especially because it is a non-invasive technique.

USING DIVERSE EXPERTISE TO ADVANCE CLIMATE CHANGE FISHERIES SCIENCE.

PubMed

Mulvaney, Kate K; Druschke, Caroline Gottschalk

2017-11-15

As climate change continues to impact New England's coastal ecosystems and their related fisheries, the need for measuring, projecting, interpreting, and applying those impacts for adaptive management is expanding. In New England, different types of formal and informal research efforts that involve collaboration between the fishing community and traditional university and government researchers continue to develop to address some of this need. To better understand the opportunities and challenges that these collaborative research efforts face, we conducted semi-structured interviews with 18 members of the fishing and research communities who are engaged in advancing New England climate change and fisheries science. Participants showed clear concern for the impacts of climate change on New England fisheries and about the insufficient availability of the necessary science to manage for those impacts. They also noted a number of challenges in collaborative research, including poor communication and a lack of trust among fishers, researchers, and decision makers, as well as a lack of perceived credibility for research coming out of the fishing community. We identify a number of opportunities for improving collaboration and communication among these groups, which could build upon the identified value of existing collaborations.

Comparison of electrochemical and thermal storage for hybrid parabolic dish solar power plants

NASA Technical Reports Server (NTRS)

Steele, H. L.; Wen, L.

1981-01-01

The economic and operating performance of a parabolic point focus array of solar electricity generators combined with either battery or thermal energy storage are examined. Noting that low-cost, mass-producible power generating units are under development for the point focus of distributed dishes, that Zn-Cl battery tests will begin in 1981 and a 100 kWh Na-S battery in 1983, the state of thermal storage requires acceleration to reach the prototype status of the batteries. Under the assumptions of 10,000 units/yr with an expected 30 yr lifetime, cost comparisons are developed for 10 types of advanced batteries. A 5 MWe plant with full thermal or 80% battery storage discharge when demand occurs in conditions of no insolation is considered, specifically for Fe-Cr redox batteries. A necessity for the doubling of fuel prices from 1980 levels by 1990 is found in order to make the systems with batteries economically competitive.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fernandes, Ana; Pereira, Rita C.; Sousa, Jorge

The Instituto de Plasmas e Fusao Nuclear (IPFN) has developed dedicated re-configurable modules based on field programmable gate array (FPGA) devices for several nuclear fusion machines worldwide. Moreover, new Advanced Telecommunication Computing Architecture (ATCA) based modules developed by IPFN are already included in the ITER catalogue. One of the requirements for re-configurable modules operating in future nuclear environments including ITER is the remote update capability. Accordingly, this work presents an alternative method for FPGA remote programing to be implemented in new ATCA based re-configurable modules. FPGAs are volatile devices and their programming code is usually stored in dedicated flash memoriesmore » for properly configuration during module power-on. The presented method is capable to store new FPGA codes in Serial Peripheral Interface (SPI) flash memories using the PCIexpress (PCIe) network established on the ATCA back-plane, linking data acquisition endpoints and the data switch blades. The method is based on the Xilinx Quick Boot application note, adapted to PCIe protocol and ATCA based modules. (authors)« less

Garnering Civic Hope: Social Studies, Expectations, and the Lost Civic Potential of Immigrant Youth

PubMed Central

Callahan, Rebecca M.; Obenchain, Kathryn M.

2016-01-01

Social studies education is designed to provide a foundation for civic society. In this study we consider immigrant optimism theory within the context of U.S. secondary social studies to examine the civic potential of immigrant youth. Using a mixed-methods approach, we complement analyses of teacher and immigrant young adult interviews with national survey data to explore how adults’ expectations shape immigrant youths’ civic identity formation. Although immigrant parents consistently express high academic expectations of their children, teachers’ civic expectations emerged as a critical factor in immigrant youths’ civic development. While teachers and immigrant youth reported rich civic discourse in advanced social studies classes, we counter that limited social studies course taking may restrict exposure to teachers’ civic expectations, and result in the unrealized civic potential of immigrant youth. We close with a cautionary note regarding the limits of social studies to develop a transformative, emancipatory citizenry, especially among the increasingly diverse immigrant youth population. PMID:27065504

The Clinical Quality Fellowship Program: Developing Clinical Quality Leadership in the Greater New York Region.

PubMed

Bhalla, Rohit; Jalon, Hillary S; Ryan, Lorraine

The Institute of Medicine has noted that a key factor underlying patient safety problems in the United States is a paucity of quality and safety training programs for clinicians. The Greater New York Hospital Association and United Hospital Fund created the Clinical Quality Fellowship Program (CQFP) to develop quality improvement leaders in the New York region. The goals of this article are to describe the CQFP's structure and curriculum, program participants' perceived value, improvement projects, and career paths. Eighty-seven participants completed the CQFP from 2010 to 2014. Among program participants completing self-assessment evaluations, significant improvements were observed across all quality improvement skill areas. Capstone project categories included inpatient efficiency, transitional care, and hospital infection. Fifty-six percent of participants obtained promotions following program completion. A training program emphasizing diverse curricular elements, varied learning approaches, and applied improvement projects increased participants' self-perceived skills, generated diverse improvement initiatives, and was associated with career advancement.

Garnering Civic Hope: Social Studies, Expectations, and the Lost Civic Potential of Immigrant Youth.

PubMed

Callahan, Rebecca M; Obenchain, Kathryn M

Social studies education is designed to provide a foundation for civic society. In this study we consider immigrant optimism theory within the context of U.S. secondary social studies to examine the civic potential of immigrant youth. Using a mixed-methods approach, we complement analyses of teacher and immigrant young adult interviews with national survey data to explore how adults' expectations shape immigrant youths' civic identity formation. Although immigrant parents consistently express high academic expectations of their children, teachers' civic expectations emerged as a critical factor in immigrant youths' civic development. While teachers and immigrant youth reported rich civic discourse in advanced social studies classes, we counter that limited social studies course taking may restrict exposure to teachers' civic expectations, and result in the unrealized civic potential of immigrant youth. We close with a cautionary note regarding the limits of social studies to develop a transformative, emancipatory citizenry, especially among the increasingly diverse immigrant youth population.

MicroRNA and Pathogenesis of Enterovirus Infection.

PubMed

Ho, Bing-Ching; Yang, Pan-Chyr; Yu, Sung-Liang

2016-01-06

There are no currently available specific antiviral therapies for non-polio Enterovirus infections. Although several vaccines have entered clinical trials, the efficacy requires further evaluation, particularly for cross-strain protective activity. Curing patients with viral infections is a public health problem due to antigen alterations and drug resistance caused by the high genomic mutation rate. To conquer these limits in the development of anti-Enterovirus treatments, a comprehensive understanding of the interactions between Enterovirus and host cells is urgently needed. MicroRNA (miRNA) constitutes the biggest family of gene regulators in mammalian cells and regulates almost a half of all human genes. The roles of miRNAs in Enterovirus pathogenesis have recently begun to be noted. In this review, we shed light on recent advances in the understanding of Enterovirus infection-modulated miRNAs. The impacts of altered host miRNAs on cellular processes, including immune escape, apoptosis, signal transduction, shutdown of host protein synthesis and viral replication, are discussed. Finally, miRNA-based medication provides a promising strategy for the development of antiviral therapy.

Aligning policing and public health promotion: Insights from the world of foot patrol

PubMed Central

Wood, Jennifer D.; Taylor, Caitlin J.; Groff, Elizabeth R.; Ratcliffe, Jerry H.

2013-01-01

Foot patrol work is rarely described in relation to public health, even though police routinely encounter health risk behaviors and environments. Through a qualitative study of foot patrol policing in violent ‘hotspots’ of Philadelphia, we explore some prospects and challenges associated with bridging security and public health considerations in law enforcement. Noting existing efforts to help advance police officer knowledge of, and attitudes toward health vulnerabilities, we incorporate perspectives from environmental criminology to help advance this bridging agenda. Extending the notion of capable guardianship to understand foot patrol work, we suggest that the way forward for theory, policy and practice is not solely to rely on changing officer culture and behavior, but rather to advance a wider agenda for enhancing collective guardianship, and especially ‘place management’ for harm reduction in the city. PMID:26085825

Aligning policing and public health promotion: Insights from the world of foot patrol.

PubMed

Wood, Jennifer D; Taylor, Caitlin J; Groff, Elizabeth R; Ratcliffe, Jerry H

2015-05-01

Foot patrol work is rarely described in relation to public health, even though police routinely encounter health risk behaviors and environments. Through a qualitative study of foot patrol policing in violent 'hotspots' of Philadelphia, we explore some prospects and challenges associated with bridging security and public health considerations in law enforcement. Noting existing efforts to help advance police officer knowledge of, and attitudes toward health vulnerabilities, we incorporate perspectives from environmental criminology to help advance this bridging agenda. Extending the notion of capable guardianship to understand foot patrol work, we suggest that the way forward for theory, policy and practice is not solely to rely on changing officer culture and behavior, but rather to advance a wider agenda for enhancing collective guardianship, and especially 'place management' for harm reduction in the city.

Recent Advances in Hydrogel-Based Drug Delivery for Melanoma Cancer Therapy: A Mini Review

PubMed Central

Elupula, Ravinder

2017-01-01

The purpose of this study is to describe some of the latest advances in using hydrogels for cancer melanoma therapy. Hydrogel formulations of polymeric material from natural or synthetic sources combined with therapeutic agents have gained great attention in the recent years for treating various maladies. These formulations can be categorized according to the strategies that induce cancer cell death in melanoma. First of all, we should note that these formulations can only play a supporting role that releases bioactive agents against cancer cells rather than the main role. This strategy involves delivering the drug via transdermal pathways, resulting in the death of cancerous cells. Another strategy utilizes magnetic gel composites to combat melanoma via hyperthermia therapy. This review discusses both transdermal and hyperthermia therapies and the recent advances that have occurred in the field. PMID:28852576

MIMIC II: a massive temporal ICU patient database to support research in intelligent patient monitoring

NASA Technical Reports Server (NTRS)

Saeed, M.; Lieu, C.; Raber, G.; Mark, R. G.

2002-01-01

Development and evaluation of Intensive Care Unit (ICU) decision-support systems would be greatly facilitated by the availability of a large-scale ICU patient database. Following our previous efforts with the MIMIC (Multi-parameter Intelligent Monitoring for Intensive Care) Database, we have leveraged advances in networking and storage technologies to develop a far more massive temporal database, MIMIC II. MIMIC II is an ongoing effort: data is continuously and prospectively archived from all ICU patients in our hospital. MIMIC II now consists of over 800 ICU patient records including over 120 gigabytes of data and is growing. A customized archiving system was used to store continuously up to four waveforms and 30 different parameters from ICU patient monitors. An integrated user-friendly relational database was developed for browsing of patients' clinical information (lab results, fluid balance, medications, nurses' progress notes). Based upon its unprecedented size and scope, MIMIC II will prove to be an important resource for intelligent patient monitoring research, and will support efforts in medical data mining and knowledge-discovery.

New luster for space robots and automation

NASA Technical Reports Server (NTRS)

Heer, E.

1978-01-01

Consideration is given to the potential role of robotics and automation in space transportation systems. Automation development requirements are defined for projects in space exploration, global services, space utilization, and space transport. In each category the potential automation of ground operations, on-board spacecraft operations, and in-space handling is noted. The major developments of space robot technology are noted for the 1967-1978 period. Economic aspects of ground-operation, ground command, and mission operations are noted.

Identity and home: Understanding the experience of people with advanced cancer.

PubMed

Maersk, Jesper Larsen; Cutchin, Malcolm P; la Cour, Karen

2018-05-01

The purpose of this study was to explore how the identity of people with advanced cancer is influenced by their experiences of living at home. A total of 28 in-depth interviews were conducted with 22 people with advanced cancer and four spouses. Grounded theory guided the collection and analysis of data. Home tours and associated field notes augmented the interview data. The analysis revealed that support of participants' identity was reflected in their abilities to live and occupy the home during daily activities, and in the ways the home and objects functioned as referents to themselves and their past. Threats to their identity ensued as the home environment became unmanageable during daily activities and as homecare professionals and assistive devices entered the home. By supporting people with advanced cancer in maintaining daily activities in the home and reducing changes in the home caused by homecare it is possible to reduce loss of identity. Copyright © 2018 Elsevier Ltd. All rights reserved.

A Natural Language Processing System That Links Medical Terms in Electronic Health Record Notes to Lay Definitions: System Development Using Physician Reviews.

PubMed

Chen, Jinying; Druhl, Emily; Polepalli Ramesh, Balaji; Houston, Thomas K; Brandt, Cynthia A; Zulman, Donna M; Vimalananda, Varsha G; Malkani, Samir; Yu, Hong

2018-01-22

Many health care systems now allow patients to access their electronic health record (EHR) notes online through patient portals. Medical jargon in EHR notes can confuse patients, which may interfere with potential benefits of patient access to EHR notes. The aim of this study was to develop and evaluate the usability and content quality of NoteAid, a Web-based natural language processing system that links medical terms in EHR notes to lay definitions, that is, definitions easily understood by lay people. NoteAid incorporates two core components: CoDeMed, a lexical resource of lay definitions for medical terms, and MedLink, a computational unit that links medical terms to lay definitions. We developed innovative computational methods, including an adapted distant supervision algorithm to prioritize medical terms important for EHR comprehension to facilitate the effort of building CoDeMed. Ten physician domain experts evaluated the user interface and content quality of NoteAid. The evaluation protocol included a cognitive walkthrough session and a postsession questionnaire. Physician feedback sessions were audio-recorded. We used standard content analysis methods to analyze qualitative data from these sessions. Physician feedback was mixed. Positive feedback on NoteAid included (1) Easy to use, (2) Good visual display, (3) Satisfactory system speed, and (4) Adequate lay definitions. Opportunities for improvement arising from evaluation sessions and feedback included (1) improving the display of definitions for partially matched terms, (2) including more medical terms in CoDeMed, (3) improving the handling of terms whose definitions vary depending on different contexts, and (4) standardizing the scope of definitions for medicines. On the basis of these results, we have improved NoteAid's user interface and a number of definitions, and added 4502 more definitions in CoDeMed. Physician evaluation yielded useful feedback for content validation and refinement of this innovative tool that has the potential to improve patient EHR comprehension and experience using patient portals. Future ongoing work will develop algorithms to handle ambiguous medical terms and test and evaluate NoteAid with patients. ©Jinying Chen, Emily Druhl, Balaji Polepalli Ramesh, Thomas K Houston, Cynthia A Brandt, Donna M Zulman, Varsha G Vimalananda, Samir Malkani, Hong Yu. Originally published in the Journal of Medical Internet Research (http://www.jmir.org), 22.01.2018.

22 CFR 231.02 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND CONDITIONS... means the United States Agency for International Development or its successor. (b) Eligible Note(s...

22 CFR 231.02 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND CONDITIONS... means the United States Agency for International Development or its successor. (b) Eligible Note(s...

22 CFR 231.02 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND CONDITIONS... means the United States Agency for International Development or its successor. (b) Eligible Note(s...

22 CFR 231.02 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND CONDITIONS... means the United States Agency for International Development or its successor. (b) Eligible Note(s...

22 CFR 231.02 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ARAB REPUBLIC OF EGYPT LOAN GUARANTEES ISSUED UNDER THE EMERGENCY WARTIME SUPPLEMENTAL APPROPRIATIONS ACT OF 2003, PUBLIC LAW 108-11-STANDARD TERMS AND CONDITIONS... means the United States Agency for International Development or its successor. (b) Eligible Note(s...

EHR based Genetic Testing Knowledge Base (iGTKB) Development

PubMed Central

2015-01-01

Background The gap between a large growing number of genetic tests and a suboptimal clinical workflow of incorporating these tests into regular clinical practice poses barriers to effective reliance on advanced genetic technologies to improve quality of healthcare. A promising solution to fill this gap is to develop an intelligent genetic test recommendation system that not only can provide a comprehensive view of genetic tests as education resources, but also can recommend the most appropriate genetic tests to patients based on clinical evidence. In this study, we developed an EHR based Genetic Testing Knowledge Base for Individualized Medicine (iGTKB). Methods We extracted genetic testing information and patient medical records from EHR systems at Mayo Clinic. Clinical features have been semi-automatically annotated from the clinical notes by applying a Natural Language Processing (NLP) tool, MedTagger suite. To prioritize clinical features for each genetic test, we compared odds ratio across four population groups. Genetic tests, genetic disorders and clinical features with their odds ratios have been applied to establish iGTKB, which is to be integrated into the Genetic Testing Ontology (GTO). Results Overall, there are five genetic tests operated with sample size greater than 100 in 2013 at Mayo Clinic. A total of 1,450 patients who was tested by one of the five genetic tests have been selected. We assembled 243 clinical features from the Human Phenotype Ontology (HPO) for these five genetic tests. There are 60 clinical features with at least one mention in clinical notes of patients taking the test. Twenty-eight clinical features with high odds ratio (greater than 1) have been selected as dominant features and deposited into iGTKB with their associated information about genetic tests and genetic disorders. Conclusions In this study, we developed an EHR based genetic testing knowledge base, iGTKB. iGTKB will be integrated into the GTO by providing relevant clinical evidence, and ultimately to support development of genetic testing recommendation system, iGenetics. PMID:26606281

EHR based Genetic Testing Knowledge Base (iGTKB) Development.

PubMed

Zhu, Qian; Liu, Hongfang; Chute, Christopher G; Ferber, Matthew

2015-01-01

The gap between a large growing number of genetic tests and a suboptimal clinical workflow of incorporating these tests into regular clinical practice poses barriers to effective reliance on advanced genetic technologies to improve quality of healthcare. A promising solution to fill this gap is to develop an intelligent genetic test recommendation system that not only can provide a comprehensive view of genetic tests as education resources, but also can recommend the most appropriate genetic tests to patients based on clinical evidence. In this study, we developed an EHR based Genetic Testing Knowledge Base for Individualized Medicine (iGTKB). We extracted genetic testing information and patient medical records from EHR systems at Mayo Clinic. Clinical features have been semi-automatically annotated from the clinical notes by applying a Natural Language Processing (NLP) tool, MedTagger suite. To prioritize clinical features for each genetic test, we compared odds ratio across four population groups. Genetic tests, genetic disorders and clinical features with their odds ratios have been applied to establish iGTKB, which is to be integrated into the Genetic Testing Ontology (GTO). Overall, there are five genetic tests operated with sample size greater than 100 in 2013 at Mayo Clinic. A total of 1,450 patients who was tested by one of the five genetic tests have been selected. We assembled 243 clinical features from the Human Phenotype Ontology (HPO) for these five genetic tests. There are 60 clinical features with at least one mention in clinical notes of patients taking the test. Twenty-eight clinical features with high odds ratio (greater than 1) have been selected as dominant features and deposited into iGTKB with their associated information about genetic tests and genetic disorders. In this study, we developed an EHR based genetic testing knowledge base, iGTKB. iGTKB will be integrated into the GTO by providing relevant clinical evidence, and ultimately to support development of genetic testing recommendation system, iGenetics.

Synchrotron sheds new light on geophysical materials

NASA Astrophysics Data System (ADS)

Carlowicz, Michael

On December 20,1996, scientists working with the Advanced Photon Source (APS) at Argonne National Laboratory in Illinois conducted “first light” experiments in a new laboratory for synchrotron radiation research in the geosciences. The demonstration marks the dawn of a new era in rock and mineral physics when, as geophysicist Thomas Duffy of Princeton University notes, researchers will be able to 'shine a bright new light on some of our planet's deepest and darkest secrets.”The new light is from the APS, a particle accelerator dedicated to the production of brilliant X rays for research, and it shone on the GeoSoilEnviroCARS (GSECARS) experimental facility. The purpose of GSECARS is to develop X-ray beamlines at the APS and make them available to scientists for frontier research in Earth, planetary, geophysics, soil, and environmental sciences.

High-temperature resins

NASA Technical Reports Server (NTRS)

Serafini, T. T.

1982-01-01

The basic chemistry, cure processes, properties, and applications of high temperature resins known as polyimides are surveyed. Condensation aromatic polymides are prepared by reacting aromatic diamines with aromatic dianhydrides, aromatic tetracarboxylic acids, or with dialkyl esters of aromatic tetracarboxylic acids, depending on the intended end use. The first is for coatings or films while the latter two are more suitable for polyimide matrix resins. Prepreg solutions are made by dissolving reactants in an aprotic solvent, and advances in the addition of a diamine on the double bond and radical polymerization of the double bond are noted to have yielded a final cure product with void-free characteristics. Attention is given to properties of the Skybond, Pyralin, and NR-150B polyimide prepreg materials and characteristics of aging in the NP-150 polyimides. Finally, features of the NASA-developed PMR polyimides are reviewed.

Contextualizing Genetics for Regional Heart Failure Care

PubMed Central

Iyngkaran, Pupalan; Thomas, Merlin C.; Johnson, Renee; French, John; Ilton, Marcus; McDonald, Peter; Hare, David L.; Fatkin, Diane

2016-01-01

Congestive heart failure (CHF) is a chronic and often devastating cardiovascular disorder with no cure. There has been much advancement in the last two decades that has seen improvements in morbidity and mortality. Clinicians have also noted variations in the responses to therapies. More detailed observations also point to clusters of diseases, phenotypic groupings, unusual severity and the rates at which CHF occurs. Medical genetics is playing an increasingly important role in answering some of these observations. This developing field in many respects provides more information than is currently clinically applicable. This includes making sense of the established single gene mutations or uncommon private mutations. In this thematic series which discusses the many factors that could be relevant for CHF care, once established treatments are available in the communities; this section addresses a contextual role for medical genetics. PMID:27280306

Inert-gas thruster technology

NASA Technical Reports Server (NTRS)

Kaufman, H. R.; Robinson, R. S.; Trock, D. C.

1981-01-01

Attention is given to recent advances in component technology for inert-gas thrusters. It is noted that the maximum electron emission of a hollow cathode with Ar can be increased 60-70% by using an enclosed keeper configuration. Operation with Ar but without emissive oxide has also been attained. A 30-cm thruster operated with Ar at moderate discharge voltages is found to give double-ion measurements consistent with a double-ion correlation developed earlier on the basis of 15-cm thruster data. An attempt is made to reduce discharge losses by biasing anodes positive of the discharge plasma. The performance of a single-grid ion-optics configuration is assessed. The ion impingement on the single-grid accelerator is found to approach the value expected from the projected blockage when the sheath thickness next to the accelerator is 2-3 times the aperture diameter.

22 CFR 221.22 - No acceleration of Eligible Notes.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false No acceleration of Eligible Notes. 221.22 Section 221.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.22 No acceleration of Eligible Notes...

22 CFR 221.22 - No acceleration of Eligible Notes.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false No acceleration of Eligible Notes. 221.22 Section 221.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.22 No acceleration of Eligible Notes...

22 CFR 221.22 - No acceleration of Eligible Notes.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false No acceleration of Eligible Notes. 221.22 Section 221.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.22 No acceleration of Eligible Notes...

22 CFR 221.22 - No acceleration of Eligible Notes.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false No acceleration of Eligible Notes. 221.22 Section 221.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.22 No acceleration of Eligible Notes...

22 CFR 221.14 - Transferability of Guarantee; Note Register.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Transferability of Guarantee; Note Register. 221.14 Section 221.14 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS The Guarantee § 221.14 Transferability of Guarantee; Note Register. A...

22 CFR 221.14 - Transferability of Guarantee; Note Register.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Transferability of Guarantee; Note Register. 221.14 Section 221.14 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS The Guarantee § 221.14 Transferability of Guarantee; Note Register. A...

22 CFR 221.14 - Transferability of Guarantee; Note Register.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Transferability of Guarantee; Note Register. 221.14 Section 221.14 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS The Guarantee § 221.14 Transferability of Guarantee; Note Register. A...

22 CFR 221.14 - Transferability of Guarantee; Note Register.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Transferability of Guarantee; Note Register. 221.14 Section 221.14 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS The Guarantee § 221.14 Transferability of Guarantee; Note Register. A...

22 CFR 221.22 - No acceleration of Eligible Notes.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false No acceleration of Eligible Notes. 221.22 Section 221.22 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS Procedure for Obtaining Compensation § 221.22 No acceleration of Eligible Notes...

22 CFR 221.14 - Transferability of Guarantee; Note Register.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Transferability of Guarantee; Note Register. 221.14 Section 221.14 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ISRAEL LOAN GUARANTEE STANDARD TERMS AND CONDITIONS The Guarantee § 221.14 Transferability of Guarantee; Note Register. A...

Engaging Participation and Promoting Active Learning through Student Usage of the Internet to Create Notes for General Chemistry in Class

ERIC Educational Resources Information Center

Henry, Renee Monica

2017-01-01

Reported here is a study of an interactive component to General Chemistry I and General Chemistry II where a new pedagogy for taking notes in class was developed. These notes, called key word created class notes, prompted students to locate information using the Internet guided by a key word. Reference Web sites were added to a next generation of…

Improved patient notes from medical students during web-based teaching using faculty-calibrated peer review and self-assessment.

PubMed

McCarty, Teresita; Parkes, Marie V; Anderson, Teresa T; Mines, Jan; Skipper, Betty J; Grebosky, James

2005-10-01

This study examines the effectiveness of Calibrated Peer Review (CPR), a Web-based writing development program, to teach and assess medical students' patient note-writing skills in a standardized fashion. At the end of the clerkship year, 67 medical students were divided into three groups, introduced to CPR, and instructed in patient note-writing. Students then wrote notes for three clinical cases, presented in different order to each group. After training on faculty-calibrated standards, students evaluated their peers' notes and their own notes. Trained faculty, blinded to author, order, and group, also graded student notes. Faculty gave lower scores than students, but both groups found students' scores improved significantly from the first to the third note written. Student-written patient notes improved in quality while using CPR. The program uses approaches valued in medicine (accurate peer review and self-reflection) to enhance performance.

Research Directions in Real-Time Systems.

DTIC Science & Technology

1996-09-01

This report summarizes a survey of published research in real time systems . Material is presented that provides an overview of the topic, focusing on...communications protocols and scheduling techniques. It is noted that real - time systems deserve special attention separate from other areas because of...formal tools for design and analysis of real - time systems . The early work on applications as well as notable theoretical advances are summarized

Keyhole Fracture of the Skull

DTIC Science & Technology

2008-12-01

unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Keyhole Fracture of the Skull irrigation and drainage of the penetrating...skull injury without craniotomy , and repair of the laceration via advancement flap Fig. 3. Diagram of forces involved in creation of keyhole...midline shift was noted. Helical CT scan performed the following day after debridement, irrigation, drainage , and closure of the gunshot wound showed

Advanced Patient Data Replication and Recovery

DTIC Science & Technology

2010-10-01

Patient Data Protection (APDAPT) Eisenhower Medical Center (EMC) is attempting to lower the risk of losing patient data, as well as the risk...includes radiological images. EMC has made a multi-million dollar investment in the digitization of patient data; the Electronic Medical Record (EMR...storage and retrieval of the patient chart or EMR. The EMR is comprised of patient vital signs, nurse notes, medications administered, doctors

Use of Methyl Salicylates As a Trialing Chemical Agent Simulant

DTIC Science & Technology

1990-05-01

phocomelia of the hind-limbs were frequently seen after injection on day 11. Hydronephrosis , ectoplc kidneys, and exencephaly were occasionally observed...Oapparent hydronephrosis " late in gestition. This apparent abnormality decreases by steady lengthening of the renal papilla with advancing fetal anw...treated fetuses at weaning., This persistent condition, suggestive, of hydronephrosis or hypoplasia, was not noted in control fetuses. Monie (1970

A Single Instance of the Pythagorean Theorem Implies the Parallel Postulate

ERIC Educational Resources Information Center

Dobbs, David E.

2002-01-01

This note could find use as enrichment material in a course on the classical geometries; its preliminary results could also be used in an advanced calculus course. It is proved that if a , b and c are positive real numbers such that a[squared] + b[squared] = c[squared] , then cosh ( a ) cosh ( b ) greater than cosh ( c ). The proof of this result…

An Analysis of the Defense Acquisition Strategy for Unmanned Systems

DTIC Science & Technology

2014-03-01

product service code RAA Rapid Acquisition Authority RCS radar cross section REF Rapid Equipping Force RFID radio frequency identification RDT...commercialization of the radio frequency identification (RFID) chip also provides a useful basis for comparison. WWII served as the proving ground for RFID...companies following the September 11 , 2001 attacks. It is important to note that despite advances in GPS technology and long-range communications

Addressing the Health Concerns of VA Women With Sexual Trauma

DTIC Science & Technology

2016-10-01

SUPPLEMENTARY NOTES 14. ABSTRACT Lifetime ST disproportionately affects women veterans and can threaten their health and wellbeing. PTSD, IPV, and...alcohol use are closely interrelated and significant concerns for women veterans with lifetime ST . Providing effective and low-cost interventions to...address ST -related risks among women veterans with lifetime ST would advance clinical care for these women in an important area. 15. SUBJECT TERMS

Near earth tracking/data exploration

NASA Technical Reports Server (NTRS)

Spearing, Robert

1990-01-01

The future challenges facing NASA's data acquisition program are examined, with emphasis on the near-earth exploration activity and the associated data systems. It is noted that the process that is being followed is an evolutionary one: new technologies are being gradually integrated into currently operating systems. For example, advanced handling is already being introduced into such programs as the Space Telescope and the Gamma Ray Source Observatory System.

Regenerative Stem Cell Therapy for Breast Cancer Bone Metastasis

DTIC Science & Technology

2014-09-01

13. SUPPLEMENTARY NOTES 14. ABSTRACT Bone is the most common site of metastasis for human breast cancer (BCa), which results in significant...to all major bones as in human patients. 15. SUBJECT TERMS Bone metastasis; osteolysis; osteoprotegerin 16. SECURITY CLASSIFICATION OF: 17...metastasis for human breast cancer (BCa), which results in significant morbidity and mortality in patients with advanced disease. A vicious cycle

Advanced Material Presentation: A Study in Technology and Ergonomics.

DTIC Science & Technology

1998-03-01

Governments and local school systems continue to invest millions of dollars into educational technology. Most of these investments have not produced as...promised and some are complete failures. The purpose of this thesis is to determine the state-of-the-art for the implementation of educational ...the instructor must spend writing notes on the blackboard is beneficial. 14. SUBJECT TERMS Information Technology, Education , 17. SECURITY

Moral Warfare in Counterinsurgency Operations

DTIC Science & Technology

2007-05-11

Moral Warfare in Counterinsurgency Operations A Monograph by MAJOR David C. Chiarenza US Army School of Advanced Military Studies United...OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM-YYYY) 11-05-2007 2. REPORT TYPE AMSP Monograph 3...Public Release; Distribution is Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT This study explores the moral level of war in the context of

Training-Based Requirements for Semi-Automated Forces

DTIC Science & Technology

1999-03-01

ARI Research Note 99-18 Training-based Requirements for Semi-Automated Forces Jim Kornell Syukhtun Research, Inc. Research and Advanced Concepts ... Concepts , Inc.; Dr. Susan Fischer, of Anacapa Sciences, Inc.; and Lt. Col. Ken Bell, ret., of THETA Technologies, Inc. All conclusions and...construed) in terms of symbols and concepts , and/or the learning of procedural knowledge. • Cognitive strategies. Skills for governing thinking. This

Space and Air Force: Rhetoric or Reality

DTIC Science & Technology

1999-04-01

1997, (introduction). 11 Ibid., 18. 12 Ibid., 17. 13 Notes 13 Joint Operations Coursebook , “Joint Strategic Planning System: CJCS Instruction 3100.01...infrastructures as “the physical and information systems essential to the operations of the economy and government.”22 The NSS also specifies, “but...advances in information technology and competitive pressure to improve efficiency and productivity have created new vulnerabilities to both physical

(Updated) Fort Detrick Gate Hours Change Effective April 10 | Poster

Cancer.gov

The Fort Detrick gate hours will change beginning Friday, April 10. The new hours were recently provided by the U.S. Army Garrison (USAG), Fort Detrick. NCI will continue to work with the USAG to address questions that may arise. Note that no changes have been made for facilities outside of the Fort Detrick campus (e.g., the Advanced Technology Research Facility).

The Evolution of Military Trauma and Critical Care Medicine: Applications for Civilian Medical Care Systems

DTIC Science & Technology

2008-01-01

evidence - based medicine . Like great leaders in medicine such as Ibn Sina, war and conflict have also been credited with advances in medical and surgical therapy throughout the centuries. Like in previous conflicts, many authors note that innovations in trauma and critical care evolving from the current global war on terrorism may significantly impact civilian trauma care, critical

AIDS Knowledge and Attitudes, Provisional Data from the National Health Interview Survey: United States, August 1987. Advance Data from Vital and Health Statistics. No. 146.

ERIC Educational Resources Information Center

Dawson, Deborah A.; And Others

This document presents provisional data for all Acquired Immune Deficiency Syndrome (AIDS) questionnaire items from the National Health Interview Survey (NHIS) for August 1987. It notes that the AIDS questionnaire was designed to provide baseline estimates of public knowledge and attitudes about AIDS transmission, the prevention of AIDS virus…

Real-Time Inspection Of Currency

NASA Astrophysics Data System (ADS)

Blazek, Henry

1986-12-01

An automatic inspection machine, designed and manufactured by the Perkin-Elmer Corporation for the U.S. Bureau of Engraving and Printing, is capable of real-time inspection of currency at rates compatible with the output of modern high-speed printing presses. Inspection is accomplished by comparing test notes (in 32-per-sheet format) with reference notes stored in the memory of a digital computer. This paper describes the development of algorithms for detecting defective notes, one of the key problems solved during the development of the inspection system. Results achieved on an analytical model, used for predicting probability of false alarms and probability of detecting typically defective notes, are compared to those obtained by system simulation.

Clinico-biochemical correlation to histological findings in alcoholic liver disease: a single centre study from eastern India.

PubMed

Ray, Sayantan; Khanra, Dibbendhu; Sonthalia, Nikhil; Kundu, Supratip; Biswas, Kaushik; Talukdar, Arunansu; Saha, Manjari; Bera, Himel

2014-10-01

Alcoholism is a health problem not only in developed countries but also in developing countries. Cirrhosis due to alcohol is a common cause of death among individuals abusing alcohol. A better knowledge of the spectrum of alcoholic liver diseases, its clinical, biochemical and histopathological features could result in early detection and prevention of alcoholic liver diseases before it's catastrophic and life threatening effects. A total of 200 patients with alcoholic liver diseases were studied with respect to alcohol consumption, clinical features, biochemical and histopathological changes. The clinical features, biochemical parameters, and histopathology of liver including Ishak's modified histological activity index (HAI) were correlated with the amount and duration of alcohol consumed. Majority of the patients were in the age group of 40-49 years and all the cases were males. Majority consumed alcohol of about 75-90 grams per day for a duration of 10-12 years. Anorexia and jaundice were the most common symptom and clinical finding respectively. Hyperbilirubinemia and hypoalbuminemia were the most common abnormalities observed in liver function tests. Advanced HAI stages with features of cirrhosis were most frequent histo-pathological finding noted in this study. Clinico-biochemical profile was significantly correlated with degree of alcohol ingestion as well as with liver histopathology. The wide prevalence of alcoholic liver disease including cirrhosis among Indian males was noted with significantly lower quantity and duration of alcohol ingestion. The severity of liver damage is directly proportional to the quantity and duration of alcohol consumed. Clinical features and biochemical changes may forecast the liver histopathology among the patients of alcoholic liver disease.

Industry perspectives

NASA Astrophysics Data System (ADS)

Fuqua, Don; Hannemann, Tim; Iacobellis, Sam F.; Young, A. Thomas

This discussion addresses the question of whether or not the space industry will take up the slack in the aerospace industry that is created by budget cuts in defense. Armed forces' research has provided an invaluable base for national technological and engineering resources for aerospace companies. It is noted that the space program should maximize the country's advances in national, scientific, and technical capabilities. It is also noted that NASA has done well in a most complicated business, but that Congress has failed to make a firm commitment to NASA's plans outlined in Vision 21 (based on the Augustine report) as evidenced by the Congressional reactions to NASA's budget requests. International cooperation and competition are discussed as well as the need for a political concensus on the direction of the space program in the U.S.

Active Galactic Nuclei

NASA Astrophysics Data System (ADS)

Blandford, R. D.; Netzer, H.; Woltjer, L.; Courvoisier, T. J.-L.; Mayor, M.

Starting with this volume, the Lecture Notes of the renowned Advanced Courses of the Swiss Society for Astrophysics and Astronomy will be published annually. In each course, three extensive lectures given by leading experts in their respective fields cover different and essential aspects of the subject. The 20th course, held at Les Diablerets in April 1990, dealt with current research on active galactic nuclei; it represents the most up-to-date views on the subject, presented with particular regard for clarity. The previous courses considered a wide variety of subjects, beginning with "Theory of Stellar Athmospheres" in 1971 and ending with "The Milky Way as a Galaxy" in 1989. The Lecture Notes of these Saas-Fee Courses appeared as publications of the Geneva Observatory, from which they can still be ordered (chemin des Maillettes 51, CH-1290 Sauverny, Switzerland).

[Lung Resection after Definitive and Neo-Adjuvant Chemoradiation for Stage IIIA/B Locally Advanced Non-Small Cell Lung Cancer: a Retrospective Analysis].

PubMed

Schreiner, Waldemar; Gavrychenkova, Sofiia; Dudek, Wojciech; Lettmaier, Sebastian; Rieker, Ralf; Fietkau, Rainer; Sirbu, Horia

2018-06-01

The outcomes of so called "salvage" resections after definitive chemoradiation vs. curative resections after neoadjuvant chemoradiation therapy (IT-resection) in patients with stage IIIA/B locally advanced non-small cell lung cancer have rarely been compared. The aim of our study was to compare perioperative results, postoperative and recurrence-free survival and to identify relevant prognostic survival factors for both therapy strategies. Between June 2008 and May 2017, 43 patients underwent pulmonary resection following induction therapy (group 1) and 14 patients underwent salvage resection after definitive chemoradiation (group 2). Retrospective analysis was performed of demographic factors, tumour stage and location, initial therapy, preoperative regression status, perioperative morbidity and mortality, postoperative and recurrence-free survival. In group 2, significantly higher radiation dose was applied (p < 0.001) and the interval between chemoradiation and lung resection was significantly longer (p = 0.02). In addition, significantly higher perioperative blood loss and more frequent blood transfusions were noted (p = 0.003 and 0.005, respectively). Perioperative morbidity and mortality were statistically comparable in the two groups (p = 0.72 and 0.395, respectively). Postoperative 5 year survival in group 1 was 55%, in group 2 48% (log-rank p = 0.353). Five year recurrence-free survival in group 1 was 53%, in group 2 42% (log-rank p = 0.180). Diffuse metastasis occurred mostly in group 2, whereas in group 1 oligometastasis was more frequently noted. Postoperative outcome after salvage resection seems statistically comparable to results following curative resection after induction therapy. Diffuse distant metastasis is frequently noted. Careful patient selection is required. Georg Thieme Verlag KG Stuttgart · New York.

Patient Disease Perceptions and Coping Strategies for Arthritis in a Developing Nation: A Qualitative Study

PubMed Central

2011-01-01

Background There is little prior research on the burden of arthritis in the developing world. We sought to document how patients with advanced arthritis living in the Dominican Republic are affected by and cope with their disease. Methods We conducted semi-structured, one-to-one interviews with economically disadvantaged Dominican patients with advanced knee and/or hip arthritis in the Dominican Republic. The interviews, conducted in Spanish, followed a moderator's guide that included topics such as the patients' understanding of disease etiology, their support networks, and their coping mechanisms. The interviews were audiotaped, transcribed verbatim in Spanish, and systematically analyzed using content analysis. We assessed agreement in coding between two investigators. Results 18 patients were interviewed (mean age 60 years, median age 62 years, 72% women, 100% response rate). Patients invoked religious and environmental theories of disease etiology, stating that their illness had been caused by God's will or through contact with water. While all patients experienced pain and functional limitation, the social effects of arthritis were gender-specific: women noted interference with homemaking and churchgoing activities, while men experienced disruption with occupational roles. The coping strategies used by patients appeared to reflect their beliefs about disease causation and included prayer and avoidance of water. Conclusions Patients' explanatory models of arthritis influenced the psychosocial effects of the disease and coping mechanisms used. Given the increasing reach of global health programs, understanding these culturally influenced perceptions of disease will be crucial in successfully treating chronic diseases in the developing world. PMID:21985605

CRISPR technologies for bacterial systems: Current achievements and future directions.

PubMed

Choi, Kyeong Rok; Lee, Sang Yup

2016-11-15

Throughout the decades of its history, the advances in bacteria-based bio-industries have coincided with great leaps in strain engineering technologies. Recently unveiled clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) systems are now revolutionizing biotechnology as well as biology. Diverse technologies have been derived from CRISPR/Cas systems in bacteria, yet the applications unfortunately have not been actively employed in bacteria as extensively as in eukaryotic organisms. A recent trend of engineering less explored strains in industrial microbiology-metabolic engineering, synthetic biology, and other related disciplines-is demanding facile yet robust tools, and various CRISPR technologies have potential to cater to the demands. Here, we briefly review the science in CRISPR/Cas systems and the milestone inventions that enabled numerous CRISPR technologies. Next, we describe CRISPR/Cas-derived technologies for bacterial strain development, including genome editing and gene expression regulation applications. Then, other CRISPR technologies possessing great potential for industrial applications are described, including typing and tracking of bacterial strains, virome identification, vaccination of bacteria, and advanced antimicrobial approaches. For each application, we note our suggestions for additional improvements as well. In the same context, replication of CRISPR/Cas-based chromosome imaging technologies developed originally in eukaryotic systems is introduced with its potential impact on studying bacterial chromosomal dynamics. Also, the current patent status of CRISPR technologies is reviewed. Finally, we provide some insights to the future of CRISPR technologies for bacterial systems by proposing complementary techniques to be developed for the use of CRISPR technologies in even wider range of applications. Copyright © 2016. Published by Elsevier Inc.

[MRSA-related empyema as thoracic surgical site infection].

PubMed

Mizutani, Hisao

2009-09-01

The incidence of empyema as a thoracic surgical site infection (SSI) is relating low, but empyema related to MRSA poses an unenviable therapeutic challenge. We review 3 cases of MRSA-related empyema as SSI seem in the last 10 years, and evaluate therapeutic measures. All 3 subjects began being administered vancomycin (VCM) systemically once the diagnosis was established. Subject 1 developed MRSA-related empyema following pulmonary segmentectomy for small-cell lung cancer. The subject was treated following a diagnosis of incisional SSI, with delayed adequate pleural drainage, resulting in treatment difficulties, but was cured without becoming MRSA-negative. Subject 2 developed MRSA-related empyema following pulmonary lobectomy for advanced lung cancer associated with pneumoconiosis. Following bronchoplasty, a chest tube was placed for long-term drainage. The subject did not become MRSA-negative after VCM administration, but became so after linezolid treatment, facilitating a cure. Subject 3, who had secondary pneumothorax, underwent thoracoscopic partial hepatic resection. Intraoperative findings suggested pleural cavity infection, necessitating a prophylactic drain, but MRSA-related pyothorax developed. Fibrinolysis with urokinase effectively cleared up the poor drainage and the subject was cured without becoming MRSA-negative. In conclusion, in controlling MRSA-related empyema as SSI noted that: (1) long-term postperative thoracic drain retention may lead to retrograde infection; (2) surgical procedures reducing the extent of pulmonary resection may effectively prevent pyothorax progression; (3) for poor drainage in advanced pyothorax, fibrinolytic therapy is worth attempting before thoracoscopic surgery; and (4) the timing for discontinuing anti-MRSA drugs should be determined based on the clinical course rather than negative conversion of bacteria.

Treatment of gingival recession defects with xenogenic collagen matrix: a histologic report.

PubMed

Camelo, Marcelo; Nevins, Myron; Nevins, Marc L; Schupbach, Peter; Kim, David M

2012-04-01

The connective tissue graft (CTG) in conjunction with a coronally advanced flap is still regarded as the gold standard treatment for gingival recession defects. Increased surgical morbidity as well as limited tissue availability continues to spur interest in alternatives to the CTG. The current case report examines a porcine-derived, double-layer collagen matrix as an alternative to the CTG in managing Miller Class I and II recession defects. A long junctional epithelial attachment as well as connective tissue adhesion were noted when collagen matrix was used in conjunction with a coronally advanced flap in recession treatment protocols. The results suggest that it is possible to obtain root coverage without harvesting connective tissue.

Pendulum Exercises After Hip Arthroscopy: A Video Technique.

PubMed

Sauber, Ryan; Saborio, George; Nickel, Beth M; Kivlan, Benjamin R; Christoforetti, John J

2016-08-01

Advanced hip joint-preserving arthroscopic techniques have been shown to improve patient-reported functional outcomes with low rates of postoperative complications. Prior work has shown that formation of adhesive scar is a potential source of persistent pain and cause for revision surgery. As resources for postoperative in-studio physical therapy become scarce, a home-based strategy to avoid scar formation without adding formal therapy cost may be beneficial. The purpose of this technical note is to introduce a patient-centered educational video technique for home-caregiver delivery of manual hip pendulum exercises in the postoperative setting. This video technique offers access to our method for pendulum exercise as part of early recovery after advanced hip arthroscopy.