Science.gov

Sample records for advanced features including

  1. PBF Control Building auxiliary features, including fire hose house and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PBF Control Building auxiliary features, including fire hose house and sewage system. Ebasco Services 1205 PER/PER-A-4. INEEL undex no. 760-0619-00-205-123024 - Idaho National Engineering Laboratory, SPERT-I & Power Burst Facility Area, Scoville, Butte County, ID

  2. Clinicopathologic Features of Advanced Squamous NSCLC.

    PubMed

    Socinski, Mark A; Obasaju, Coleman; Gandara, David; Hirsch, Fred R; Bonomi, Philip; Bunn, Paul; Kim, Edward S; Langer, Corey J; Natale, Ronald B; Novello, Silvia; Paz-Ares, Luis; Pérol, Maurice; Reck, Martin; Ramalingam, Suresh S; Reynolds, Craig H; Spigel, David R; Stinchcombe, Thomas E; Wakelee, Heather; Mayo, Carlos; Thatcher, Nick

    2016-09-01

    Lung cancer remains the leading cause of cancer-related death worldwide. NSCLC accounts for more than 85% of all lung cancers, and the prognosis for advanced-stage disease is typically poor. In recent years, the importance of histologic subtypes of NSCLC has been recognized, and the distinction between squamous and other NSCLC histologic subtypes is now critical to patient management. Squamous cell lung cancer (sqCLC) represents approximately 25% to 30% of NSCLC. The prognosis for patients with advanced NSCLC is poorer for those with sqCLC than for those with adenocarcinoma. This is partly due to a number of clinical characteristics that distinguish sqCLC from other NSCLC histologic subtypes, such as smoking history, comorbid diseases, age, and molecular profile. Together, these factors make sqCLC an especially challenging disease to manage. Herein, we review some of the key clinicopathologic features of sqCLC. Understanding these features to optimally address many of the unique therapeutic challenges of this disease is likely to be central to ultimately improving outcomes for patients with squamous NSCLC.

  3. Advanced features of SCD's uncooled detectors

    NASA Astrophysics Data System (ADS)

    Fraenkel, A.; Mizrahi, U.; Bykov, L.; Adin, A.; Malkinson, E.; Zabar, Y.; Seter, D.; Gebil, Y.; Kopolovich, Z.

    2006-03-01

    SCD has recently presented an uncooled detector product line based on the high-end VOx bolometer technology. The first FPA launched, BIRD, is a 384×288 (or 320×240) configurable format with 25 μm pitch. Typical NETD values for these FPAs range at 50 mK with an F/1 aperture and 60 Hz frame rate. These detectors also exhibit a relatively fast thermal time constant of approximately 10 ms. In this paper we elaborate on the special advanced features that were incorporated within the ROIC and supporting algorithms. In this framework we have addressed two important issues: the power consumption and the time span between shutter activations. Minimum power consumption is a critical issue for many un-cooled applications. SCD has addressed this by introducing the "power-save" concept accompanied with flexible dilution architecture. The paper will present recent results exhibiting the various advantages. One of the limiting factors on the performance of uncooled detectors is their vulnerability to ambient drift. Usually, even minor temperature fluctuations are manifested as high residual non-uniformity (RNU) or fixed pattern noise (FPN). As a result frequent shutter operations must be applied, with the risk of blocking the scenery in critical time frames. The challenge is thus twofold: to increase the time span between shutter corrections and achieve better control of its activation. For this purpose BIRD provides two complementing mechanisms: A real-time (frame-by-frame) ambient drift compensation accompanied by an RNU prediction mechanism. The paper will discuss these features in detail and present illustrative system implementations.

  4. Advanced features of SCD's uncooled detectors

    NASA Astrophysics Data System (ADS)

    Fraenkel, A.; Mizrahi, U.; Bykov, L.; Adin, A.; Malkinson, E.; Zabar, Y.; Seter, D.; Gebil, Y.; Kopolovich, Z.

    2005-09-01

    SCD has recently presented an un-cooled detector product line based on the high-end VOx bolometer technology1. The first PFA launched, BIRD, is a 384x288 (or 320x240) configurable format with 25μm pitch. Typical NETD values for these FPAs range at 50mK with an F/1 aperture and 60 Hz frame rate. These detectors also exhibit a relatively fast thermal time constant of approximately 10 msec. In this paper we elaborate on the special advanced features that were incorporated within the ROIC and supporting algorithms. In this framework we have addressed two important issues: the power consumption and the time span between shutter activations. Minimum power consumption is a critical issue for many un-cooled applications. SCD has addressed this by introducing the "Power-Save" concept accompanied with flexible dilution architecture. The paper will present recent results exhibiting the various advantages. One of the limiting factors on the performance of un-cooled detectors is their vulnerability to ambient drift. Usually, even minor temperature fluctuations are manifested as high residual non-uniformity (RNU) or fixed pattern noise (FPN). As a result frequent shutter operations must be applied, with the risk of blocking the scenery in critical time frames. The challenge is thus twofold: increase the time span between shutter corrections and achieve better control of its activation. For this purpose BIRD provides two complementing mechanisms: A real-time (frame-by-frame) ambient drift compensation accompanied by an RNU prediction mechanism. The paper will discuss these features in detail and present illustrative system implementations.

  5. Feature-based tolerancing for advanced manufacturing applications

    SciTech Connect

    Brown, C.W.; Kirk, W.J. III; Simons, W.R.; Ward, R.C.; Brooks, S.L.

    1994-11-01

    A primary requirement for the successful deployment of advanced manufacturing applications is the need for a complete and accessible definition of the product. This product definition must not only provide an unambiguous description of a product`s nominal shape but must also contain complete tolerance specification and general property attributes. Likewise, the product definition`s geometry, topology, tolerance data, and modeler manipulative routines must be fully accessible through a robust application programmer interface. This paper describes a tolerancing capability using features that complements a geometric solid model with a representation of conventional and geometric tolerances and non-shape property attributes. This capability guarantees a complete and unambiguous definition of tolerances for manufacturing applications. An object-oriented analysis and design of the feature-based tolerance domain was performed. The design represents and relates tolerance features, tolerances, and datum reference frames. The design also incorporates operations that verify correctness and check for the completeness of the overall tolerance definition. The checking algorithm is based upon the notion of satisfying all of a feature`s toleranceable aspects. Benefits from the feature-based tolerance modeler include: advancing complete product definition initiatives, incorporating tolerances in product data exchange, and supplying computer-integrated manufacturing applications with tolerance information.

  6. The Development of a Pilot Library of Cassette Tapes Dealing with Recent Advances in the Strategies and Features of Educational Research. Final Report. Including a Report of an External Project Evaluation Conducted by Jerry L. Brown, Indiana University.

    ERIC Educational Resources Information Center

    Popham, W. James

    A project was designed to develop and test a library of cassette audiotapes for improving the technical skills of educational researchers. Fourteen outstanding researchers from diverse fields were identified, and a short instructional tape was prepared by each. Subjects of the tapes included instructional objectives for intellectual skills,…

  7. Pancreatic neuroendocrine tumors: clinical features, diagnosis and medical treatment: advances

    PubMed Central

    Ito, Tetsuhide; Igarashi, Hisato; Jensen, Robert T.

    2013-01-01

    Pancreatic neuroendocrine tumors (pNETs) comprise with gastrointestinal carcinoids, the main groups of gastrointestinal neuroendocrine tumors (GI-NETs). Although these two groups of GI-NETs share many features including histological aspects; over-/ectopic expression of somatostatin receptors; the ability to ectopically secrete hormones/peptides/amines which can result in distinct functional syndromes; similar approaches used for tumor localization and some aspects of treatment, it is now generally agreed they should be considered separate. They differ in their pathogenesis, hormonal syndromes produced, many aspects of biological behavior and most important, in their response to certain anti-tumor treatment (chemotherapy, molecular targeted therapies). In this chapter the clinical features of the different types of pNETs will be considered as well as aspects of their diagnosis and medical treatment of the hormone-excess state. Emphasis will be on controversial areas or recent advances. The other aspects of the management of these tumors (surgery, treatment of advanced disease, tumor localization) are not dealt with here, because they are covered in other chapters in this volume. PMID:23582916

  8. Advances in pleural disease management including updated procedural coding.

    PubMed

    Haas, Andrew R; Sterman, Daniel H

    2014-08-01

    Over 1.5 million pleural effusions occur in the United States every year as a consequence of a variety of inflammatory, infectious, and malignant conditions. Although rarely fatal in isolation, pleural effusions are often a marker of a serious underlying medical condition and contribute to significant patient morbidity, quality-of-life reduction, and mortality. Pleural effusion management centers on pleural fluid drainage to relieve symptoms and to investigate pleural fluid accumulation etiology. Many recent studies have demonstrated important advances in pleural disease management approaches for a variety of pleural fluid etiologies, including malignant pleural effusion, complicated parapneumonic effusion and empyema, and chest tube size. The last decade has seen greater implementation of real-time imaging assistance for pleural effusion management and increasing use of smaller bore percutaneous chest tubes. This article will briefly review recent pleural effusion management literature and update the latest changes in common procedural terminology billing codes as reflected in the changing landscape of imaging use and percutaneous approaches to pleural disease management.

  9. Hairy cell leukemia: clinical features and therapeutic advances.

    PubMed

    Lembersky, B C; Golomb, H M

    1987-01-01

    Hairy cell leukemia (HCL) is a rare chronic lymphoproliferative disorder which has been extensively studied over the past decade. Much has been learned regarding the diagnosis, natural history, biology, and treatment of this unique neoplasm. The disease most commonly affects middle aged men and characteristic clinical features include splenomegaly, cytopenias, and usually the presence in the peripheral blood of distinctive 'hairy cells' with irregular cytoplasmic projections. Diagnosis can usually be confirmed by bone marrow biopsy. Although the natural history can be extremely variable among patients, complications are usually referable to the cytopenias, with anemia and infection being most frequent. In addition to pyogenic infections, patients are susceptible to unusual organisms including atypical mycobacterium, legionella, and fungi. The requirement of red blood cell transfusion, severe granulocytopenia or thrombocytopenia, frequent infections, or painful splenomegaly are all indications for treatment. Splenectomy is the standard initial treatment of choice. However, in the past few years there have been exciting major advances in the therapeutic modalities for HCL. Recombinant alpha-interferon is highly effective, with beneficial responses occurring in close to 90% of patients. The Food and Drug Administration has recently approved the use of interferon for HCL. This represents the first time a biological response modifier has been approved for the treatment of human disease. In addition, preliminary results with the adenosine deaminase inhibitor, 2'deoxycoformycin (dcf), have been encouraging. Further clinical trials are required in order to determine the optimal sequential treatment strategy for HCL. The exact mechanisms of action of both interferon and dcf in HCL remain to be elucidated. A better understanding of the unusual features of the hairy cell and the underlying biological effect of these two agents in HCL may have important applications in other

  10. NASA Trapezoidal Wing Computations Including Transition and Advanced Turbulence Modeling

    NASA Technical Reports Server (NTRS)

    Rumsey, C. L.; Lee-Rausch, E. M.

    2012-01-01

    Flow about the NASA Trapezoidal Wing is computed with several turbulence models by using grids from the first High Lift Prediction Workshop in an effort to advance understanding of computational fluid dynamics modeling for this type of flowfield. Transition is accounted for in many of the computations. In particular, a recently-developed 4-equation transition model is utilized and works well overall. Accounting for transition tends to increase lift and decrease moment, which improves the agreement with experiment. Upper surface flap separation is reduced, and agreement with experimental surface pressures and velocity profiles is improved. The predicted shape of wakes from upstream elements is strongly influenced by grid resolution in regions above the main and flap elements. Turbulence model enhancements to account for rotation and curvature have the general effect of increasing lift and improving the resolution of the wing tip vortex as it convects downstream. However, none of the models improve the prediction of surface pressures near the wing tip, where more grid resolution is needed.

  11. Recent progress and advances in iterative software (including parallel aspects)

    SciTech Connect

    Carey, G.; Young, D.M.; Kincaid, D.

    1994-12-31

    The purpose of the workshop is to provide a forum for discussion of the current state of iterative software packages. Of particular interest is software for large scale engineering and scientific applications, especially for distributed parallel systems. However, the authors will also review the state of software development for conventional architectures. This workshop will complement the other proposed workshops on iterative BLAS kernels and applications. The format for the workshop is as follows: To provide some structure, there will be brief presentations, each of less than five minutes duration and dealing with specific facets of the subject. These will be designed to focus the discussion and to stimulate an exchange with the participants. Issues to be covered include: The evolution of iterative packages, current state of the art, the parallel computing challenge, applications viewpoint, standards, and future directions and open problems.

  12. Developing and Integrating Advanced Movement Features Improves Automated Classification of Ciliate Species

    PubMed Central

    Soleymani, Ali; Pennekamp, Frank; Petchey, Owen L.; Weibel, Robert

    2015-01-01

    Recent advances in tracking technologies such as GPS or video tracking systems describe the movement paths of individuals in unprecedented details and are increasingly used in different fields, including ecology. However, extracting information from raw movement data requires advanced analysis techniques, for instance to infer behaviors expressed during a certain period of the recorded trajectory, or gender or species identity in case data is obtained from remote tracking. In this paper, we address how different movement features affect the ability to automatically classify the species identity, using a dataset of unicellular microbes (i.e., ciliates). Previously, morphological attributes and simple movement metrics, such as speed, were used for classifying ciliate species. Here, we demonstrate that adding advanced movement features, in particular such based on discrete wavelet transform, to morphological features can improve classification. These results may have practical applications in automated monitoring of waste water facilities as well as environmental monitoring of aquatic systems. PMID:26680591

  13. RELAP5-3D Code Includes ATHENA Features and Models

    SciTech Connect

    Riemke, Richard A.; Davis, Cliff B.; Schultz, Richard R.

    2006-07-01

    Version 2.3 of the RELAP5-3D computer program includes all features and models previously available only in the ATHENA version of the code. These include the addition of new working fluids (i.e., ammonia, blood, carbon dioxide, glycerol, helium, hydrogen, lead-bismuth, lithium, lithium-lead, nitrogen, potassium, sodium, and sodium-potassium) and a magnetohydrodynamic model that expands the capability of the code to model many more thermal-hydraulic systems. In addition to the new working fluids along with the standard working fluid water, one or more noncondensable gases (e.g., air, argon, carbon dioxide, carbon monoxide, helium, hydrogen, krypton, nitrogen, oxygen, SF{sub 6}, xenon) can be specified as part of the vapor/gas phase of the working fluid. These noncondensable gases were in previous versions of RELAP5-3D. Recently four molten salts have been added as working fluids to RELAP5-3D Version 2.4, which has had limited release. These molten salts will be in RELAP5-3D Version 2.5, which will have a general release like RELAP5-3D Version 2.3. Applications that use these new features and models are discussed in this paper. (authors)

  14. RELAP5-3D Code Includes Athena Features and Models

    SciTech Connect

    Richard A. Riemke; Cliff B. Davis; Richard R. Schultz

    2006-07-01

    Version 2.3 of the RELAP5-3D computer program includes all features and models previously available only in the ATHENA version of the code. These include the addition of new working fluids (i.e., ammonia, blood, carbon dioxide, glycerol, helium, hydrogen, lead-bismuth, lithium, lithium-lead, nitrogen, potassium, sodium, and sodium-potassium) and a magnetohydrodynamic model that expands the capability of the code to model many more thermal-hydraulic systems. In addition to the new working fluids along with the standard working fluid water, one or more noncondensable gases (e.g., air, argon, carbon dioxide, carbon monoxide, helium, hydrogen, krypton, nitrogen, oxygen, sf6, xenon) can be specified as part of the vapor/gas phase of the working fluid. These noncondensable gases were in previous versions of RELAP5- 3D. Recently four molten salts have been added as working fluids to RELAP5-3D Version 2.4, which has had limited release. These molten salts will be in RELAP5-3D Version 2.5, which will have a general release like RELAP5-3D Version 2.3. Applications that use these new features and models are discussed in this paper.

  15. SU-E-QI-20: A Review of Advanced PET and CT Image Features for the Evaluation of Tumor Response

    SciTech Connect

    Lu, W

    2014-06-15

    Purpose: To review the literature in using quantitative PET and CT image features for the evaluation of tumor response. Methods: We reviewed and summarized more than fifty papers that use advanced, quantitative PET/CT image features for the evaluation of tumor response. We also discussed future works on extracting disease-specific features, combining multiple and complementary features in response modeling, delineating tumor in multimodality images, and exploring biological explanations of these advanced features. Results: Advanced PET image features considering spatial information, such as tumor volume, tumor shape, total glycolytic volume, histogram distance, and texture features (characterizing spatial distribution of FDG uptake) have been found more informative than the traditional SUVmax for the prediction of tumor response. Advanced CT features, including volumetric, attenuation, morphologic, structure, and texture descriptors, have also been found advantage over the traditional RECIST and WHO criteria in certain tumor types. Conclusions: Advanced, quantitative FDG PET/CT image features have been shown promising for the evaluation of tumor response. With the emerging multi-modality imaging performed at multiple time points for each patient, it becomes more important to analyze the serial images quantitatively, select and combine both complementary and contradictory information from various sources, for accurate and personalized evaluation of tumor response to therapy.

  16. Oropharyngeal Dysphagia in Dermatomyositis: Associations with Clinical and Laboratory Features Including Autoantibodies

    PubMed Central

    Mugii, Naoki; Hasegawa, Minoru; Matsushita, Takashi; Hamaguchi, Yasuhito; Oohata, Sacihe; Okita, Hirokazu; Yahata, Tetsutarou; Someya, Fujiko; Inoue, Katsumi; Murono, Shigeyuki; Fujimoto, Manabu; Takehara, Kazuhiko

    2016-01-01

    Objective Dysphagia develops with low frequency in patients with dermatomyositis. Our objective was to determine the clinical and laboratory features that can estimate the development of dysphagia in dermatomyositis. Methods This study included 92 Japanese patients with adult-onset dermatomyositis. The associations between dysphagia and clinical and laboratory features including disease-specific autoantibodies determined by immunoprecipitation assays were analyzed. Results Videofluoroscopy swallow study (VFSS) was performed for all patients with clinical dysphagia (n = 13, 14.1%) but not for patients without clinical dysphagia. Typical findings of dysphagia (pharyngeal pooling, n = 11 and/or nasal regurgitation, n = 4) was detected by VFSS in all patients with clinical dysphagia. Eleven patients with dysphagia (84.6%) had anti-transcription intermediary factor 1γ (TIF-1γ) antibody. By univariate analysis, the average age and the male to female ratio, internal malignancy, and anti-TIF-1γ antibody were significantly higher and the frequency of interstitial lung diseases and manual muscle testing (MMT) scores of sternomastoid and dertoid muscles were significantly lower in patients with dysphagia than in patients without dysphagia. Among patients with anti-TIF-1γ antibody, the mean age, the ratios of male to female and internal malignancy were significantly higher and mean MMT scores of sternomastoid muscle were significantly lower in patients with dysphagia compared with patients without dysphagia. By multivariable analysis, the risk of dysphagia was strongly associated with the existence of internal malignancy and ant-TIF-1γ antibody and was also associated with reduced scores of manual muscle test of sternomastoid muscle. Dysphagia was markedly improved after the treatment against myositis in all 13 patients. Conclusion These findings indicate that dysphagia can develop frequently in patients with internal malignancy, anti-TIF-1γ antibody, or severe muscle

  17. The development and features of the Spanish prehospital advanced triage method (META) for mass casualty incidents.

    PubMed

    Arcos González, Pedro; Castro Delgado, Rafael; Cuartas Alvarez, Tatiana; Garijo Gonzalo, Gracia; Martinez Monzon, Carlos; Pelaez Corres, Nieves; Rodriguez Soler, Alberto; Turegano Fuentes, Fernando

    2016-01-01

    This text describes the process of development of the new Spanish Prehospital Advanced Triage Method (META) and explain its main features and contribution to prehospital triage systems in mass casualty incidents. The triage META is based in the Advanced Trauma Life Support (ATLS) protocols, patient's anatomical injuries and mechanism of injury. It is a triage method with four stages including early identification of patients with severe trauma that would benefit from a rapid evacuation to a surgical facility and introduces a new patient flow by-passing the advanced medical post to improve evacuation. The stages of triage META are: I) Stabilization triage that classifies patients according to severity to set priorities for initial emergency treatment; II) Identifying patients requiring urgent surgical treatment, this is done at the same time than stage I and creates a new flow of patients with high priority for evacuation; III) Implementation of Advanced Trauma Life Support protocols to patients previously classified according to stablished priority; and IV) Evacuation triage, stablishing evacuation priorities in case of lacks of appropriate transport resources. The triage META is to be applied only by prehospital providers with advanced knowledge and training in advanced trauma life support care and has been designed to be implemented as prehospital procedure in mass casualty incidents (MCI). PMID:27130042

  18. 77 FR 48550 - Technicolor Creative Services, Post Production Feature Mastering Division Including On-Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... related to post-production services for films. The initial investigation resulted in a negative... Employment and Training Administration Technicolor Creative Services, Post Production Feature Mastering... 23, 2012, a state workforce agent requested administrative reconsideration of the...

  19. (Advanced accelerator physics featuring the problems of small rings)

    SciTech Connect

    Olsen, D.K.

    1989-10-16

    The traveler attended the CERN Accelerator School and Uppsala University short course on Advanced Accelerator Physics held on the University campus, Uppsala, Sweden, from September 18-29, 1989. The course, attended by 81 people, was well conceived, well presented, and informative. The course was organized and specialized on the problems of small rings. The traveler also visited the CELSIUS ring facility of Uppsala University and the CRYRING ring facility of the Manne Siegbahn Institute in Stockholm, Sweden.

  20. Imaging Features of Breast Dermatofibrosarcoma Protuberans in Various Modalities Including FDG-PET CT

    PubMed Central

    Bae, Suk Hyun; Lee, Ji Young

    2016-01-01

    Dermatofibrosarcoma protuberans is an uncommon malignant mesenchymal tumor of the dermis, which most commonly appears on the body and extremities. A preoperative diagnosis of dermatofibrosarcoma protuberans is extremely difficult, because it is a very rare entity and its appearance is often similar to that of benign breast lesion. Here, we presented a case of breast dermatofibrosarcoma protuberans with associated radiological mammography, ultrasound, magnetic resonance imaging and fludeoxyglucose-positron emission tomography computerized tomography (FDG-PET CT) features. To our knowledge, our case is the first report of PET-CT findings of breast dermatofibrosarcoma protuberans. Furthermore, we reviewed characteristic radiologic features of this rare entity, which are helpful for differentiating it from other primary benign breast lesions. PMID:27703659

  1. Integrating Vocational & Academic Education. A Handbook Featuring Four Demonstration Sites Including Students from Special Populations.

    ERIC Educational Resources Information Center

    Tindall, Lloyd W.; And Others

    This handbook describes the processes and techniques used to develop, implement, and evaluate four integrated vocational and academic learning programs in Wisconsin that included students from special populations. The handbook contains seven chapters. Chapter 1 presents an overview of the project, including the request for proposal process and…

  2. WE-D-BRD-01: Innovation in Radiation Therapy Delivery: Advanced Digital Linac Features

    SciTech Connect

    Xing, L; Wong, J; Li, R

    2014-06-15

    Last few years has witnessed significant advances in linac technology and therapeutic dose delivery method. Digital linacs equipped with high dose rate FFF beams have been clinically implemented in a number of hospitals. Gated VMAT is becoming increasingly popular in treating tumors affected by respiratory motion. This session is devoted to update the audience with these technical advances and to present our experience in clinically implementing the new linacs and dose delivery methods. Topics to be covered include, technical features of new generation of linacs from different vendors, dosimetric characteristics and clinical need for FFF-beam based IMRT and VMAT, respiration-gated VMAT, the concept and implementation of station parameter optimized radiation therapy (SPORT), beam level imaging and onboard image guidance tools. Emphasis will be on providing fundamental understanding of the new treatment delivery and image guidance strategies, control systems, and the associated dosimetric characteristics. Commissioning and acceptance experience on these new treatment delivery technologies will be reported. Clinical experience and challenges encountered during the process of implementation of the new treatment techniques and future applications of the systems will also be highlighted. Learning Objectives: Present background knowledge of emerging digital linacs and summarize their key geometric and dosimetric features. SPORT as an emerging radiation therapy modality specifically designed to take advantage of digital linacs. Discuss issues related to the acceptance and commissioning of the digital linacs and FFF beams. Describe clinical utility of the new generation of digital linacs and their future applications.

  3. Ultrawideband radar target discrimination utilizing an advanced feature set

    NASA Astrophysics Data System (ADS)

    Nguyen, Lam H.; Kapoor, Ravinder; Wong, David C.; Sichina, Jeffrey

    1998-09-01

    The Army Research Laboratory, as part of its mission-funded applied research program, has been evaluating the utility of a low-frequency, ultra wideband imaging radar to detect tactical vehicles concealed by foliage. Measurement programs conducted at Aberdeen Proving Grounds and elsewhere have yielded a significant and unique database of extremely wideband and (in some cases) fully polarimetric data. Prior work has concentrated on developing computationally efficient methods to quickly canvass large quantities of data to identify likely target occurrences--often called `prescreening.' This paper reviews recent findings from our phenomenology/detection efforts. Included is a reformulated prescreener that has been trained and tested against a significantly larger data set than was used in the prior work. Also discussed are initial efforts aimed at the discrimination of targets from the difficult clutter remaining after prescreening. Performance assessments are included that detail detection rates versus false alarm levels.

  4. Serrated polyps of the colon and rectum: Endoscopic features including image enhanced endoscopy

    PubMed Central

    Saito, Shoichi; Tajiri, Hisao; Ikegami, Masahiro

    2015-01-01

    In this review, I outline the characteristic endoscopic findings of serrated lesions of the colorectum based on image enhanced endoscopy (IEE). Histopathologically, lesions with serrated structures are typically classified into the following three types based: hyperplastic polyps (HPs), traditional serrated adenomas (TSAs), and sessile serrated adenoma/polyps (SSA/Ps). Both HP and SSA/P often present as dark-green colors on auto fluorescence imaging (AFI) colonoscopy that are similar to the normal surrounding mucosa. In contrast, TSAs often have elevated shapes and present as magenta colors that are similar to the tubular adenomas. The superficial type of TSA also includes many lesions that present as magenta colors. When SSA/Ps are associated with cytological dysplasia, many lesions present with magenta colors, whereas lesions that are not associated with cytological dysplasia present with dark-green colors. When observed via narrow band imaging (NBI), many SSA/P include lesions with strong mucous adhesions. Because these lesions are observed with reddish mucous adhesions, we refer to them as “red cap sign” and place such signs among the typical findings of SSA/P. Because the dilatation of the pit in SSA/P is observed as a round/oval black dot on magnified observations, we refer to this finding as II-dilatation pit (II-D pit) and also positioned it as a characteristic finding of SSA/P. In contrast, dilatations of the capillary vessels surrounding the glands, such as those that occur in tubular adenoma, are not considered to be useful for differentiating HPs from SSA/Ps. However, in cases in which SSA/P is associated with cytological dysplasia, the dilatation of capillary vessels is observed in the same area. When submucosal layer invasion occurs in the same area, the blood flow presents with irregularities that are similar to those of common colorectal cancer at an early stage and disappears as the invasion proceeds deeply. The surface pattern of invasive

  5. Transverse tubules are a common feature in large mammalian atrial myocytes including human.

    PubMed

    Richards, M A; Clarke, J D; Saravanan, P; Voigt, N; Dobrev, D; Eisner, D A; Trafford, A W; Dibb, K M

    2011-11-01

    Transverse (t) tubules are surface membrane invaginations that are present in all mammalian cardiac ventricular cells. The apposition of L-type Ca(2+) channels on t tubules with the sarcoplasmic reticulum (SR) constitutes a "calcium release unit" and allows close coupling of excitation to the rise in systolic Ca(2+). T tubules are virtually absent in the atria of small mammals, and therefore Ca(2+) release from the SR occurs initially at the periphery of the cell and then propagates into the interior. Recent work has, however, shown the occurrence of t tubules in atrial myocytes from sheep. As in the ventricle, Ca(2+) release in these cells occurs simultaneously in central and peripheral regions. T tubules in both the atria and the ventricle are lost in disease, contributing to cellular dysfunction. The aim of this study was to determine if the occurrence of t tubules in the atrium is restricted to sheep or is a more general property of larger mammals including humans. In atrial tissue sections from human, horse, cow, and sheep, membranes were labeled using wheat germ agglutinin. As previously shown in sheep, extensive t-tubule networks were present in horse, cow, and human atrial myocytes. Analysis shows half the volume of the cell lies within 0.64 ± 0.03, 0.77 ± 0.03, 0.84 ± 0.03, and 1.56 ± 0.19 μm of t-tubule membrane in horse, cow, sheep, and human atrial myocytes, respectively. The presence of t tubules in the human atria may play an important role in determining the spatio-temporal properties of the systolic Ca(2+) transient and how this is perturbed in disease.

  6. Automatic extraction of initial moving object based on advanced feature and video analysis

    NASA Astrophysics Data System (ADS)

    Liu, Mao-Ying; Dai, Qiong-Hai; Liu, Xiao-Dong; Er, Gui-Hua

    2005-07-01

    Traditionally, video segmentation usually extracts object using low-level features such as color, texture, edge, motion, and optical flow. This paper originally proposes that the connectivity of object motion is an advanced feature of video moving object because it can reflect semantic meanings of object to some extent. And it can be fully represented on cumulated difference image which is the combination of a certain number of interframe difference images. Based on this principle, a novel system is designed to extract initial moving object automatically. The system includes 3 key innovations: 1) System is applied on cumulated difference image which can make object more prominent than background noise. Object extraction is based on the connectivity of object motion and it can guarantee the integrity of the extracted object while eliminate big background regions which cannot be removed by conventional change detection methods, for example, intense-noise regions and shadow regions that are not connected tightly to object. 2) Video sequence analysis is performed ahead of video segmentation. Proper object extraction methods are adopted according to the characteristics of background noise and object motion. 3) The adaptive threshold is automatically determined on cumulated difference image after acute noises is removed. The threshold determined here is more reasonable. And with it, most noise can be eliminated while small-motion regions of object are preserved. Results show that this system can extract object in different kinds of sequences automatically, promptly and properly. Thus, this system is very suitable for real time video applications.

  7. Zebrafish Caudal Fin Angiogenesis Assay—Advanced Quantitative Assessment Including 3-Way Correlative Microscopy

    PubMed Central

    Correa Shokiche, Carlos; Schaad, Laura; Triet, Ramona; Jazwinska, Anna; Tschanz, Stefan A.; Djonov, Valentin

    2016-01-01

    Background Researchers evaluating angiomodulating compounds as a part of scientific projects or pre-clinical studies are often confronted with limitations of applied animal models. The rough and insufficient early-stage compound assessment without reliable quantification of the vascular response counts, at least partially, to the low transition rate to clinics. Objective To establish an advanced, rapid and cost-effective angiogenesis assay for the precise and sensitive assessment of angiomodulating compounds using zebrafish caudal fin regeneration. It should provide information regarding the angiogenic mechanisms involved and should include qualitative and quantitative data of drug effects in a non-biased and time-efficient way. Approach & Results Basic vascular parameters (total regenerated area, vascular projection area, contour length, vessel area density) were extracted from in vivo fluorescence microscopy images using a stereological approach. Skeletonization of the vasculature by our custom-made software Skelios provided additional parameters including “graph energy” and “distance to farthest node”. The latter gave important insights into the complexity, connectivity and maturation status of the regenerating vascular network. The employment of a reference point (vascular parameters prior amputation) is unique for the model and crucial for a proper assessment. Additionally, the assay provides exceptional possibilities for correlative microscopy by combining in vivo-imaging and morphological investigation of the area of interest. The 3-way correlative microscopy links the dynamic changes in vivo with their structural substrate at the subcellular level. Conclusions The improved zebrafish fin regeneration model with advanced quantitative analysis and optional 3-way correlative morphology is a promising in vivo angiogenesis assay, well-suitable for basic research and preclinical investigations. PMID:26950851

  8. Biological Features of the Soil: Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the third of six modules in advanced crop and soil science and introduces the agriculture student to biological features of soil. Upon completing the two day lesson, the student will: (1) realize the vast amount of life present in the soil, (2) be able to list representative animal and plant life in the soil by size,…

  9. Physical Features of Soil: Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the second of six modules in advanced crop and soil science and introduces the agriculture student to the subject of physical features of the soil. Upon completing the two day lesson, the student will be able to determine the texture and structural types of soil, list the structural classes of the soil and where they…

  10. Advanced neuroblastoma: improved response rate using a multiagent regimen (OPEC) including sequential cisplatin and VM-26.

    PubMed

    Shafford, E A; Rogers, D W; Pritchard, J

    1984-07-01

    Forty-two children, all over one year of age, were given vincristine, cyclophosphamide, and sequentially timed cisplatin and VM-26 (OPEC) or OPEC and doxorubicin (OPEC-D) as initial treatment for newly diagnosed stage III or IV neuroblastoma. Good partial response was achieved in 31 patients (74%) overall and in 28 (78%) of 36 patients whose treatment adhered to the chemotherapy protocol, compared with a 65% response rate achieved in a previous series of children treated with pulsed cyclophosphamide and vincristine with or without doxorubicin. Only six patients, including two of the six children whose treatment did not adhere to protocol, failed to respond, but there were five early deaths from treatment-related complications. Tumor response to OPEC, which was the less toxic of the two regimens, was at least as good as tumor response to OPEC-D. Cisplatin-induced morbidity was clinically significant in only one patient and was avoided in others by careful monitoring of glomerular filtration rate and hearing. Other centers should test the efficacy of OPEC or equivalent regimens in the treatment of advanced neuroblastoma. PMID:6539811

  11. Identification and characterization of passive safety system and inherent safety feature building blocks for advanced light-water reactors

    SciTech Connect

    Forsberg, C.W.

    1989-01-01

    Oak Ridge National Laboratory (ORNL) is investigating passive and inherent safety options for Advanced Light-Water Reactors (ALWRs). A major activity in 1989 includes identification and characterization of passive safety system and inherent safety feature building blocks, both existing and proposed, for ALWRs. Preliminary results of this work are reported herein. This activity is part of a larger effort by the US Department of Energy, reactor vendors, utilities, and others in the United States to develop improved LWRs. The Advanced Boiling Water Reactor (ABWR) program and the Advanced Pressurized Water Reactor (APWR) program have as goals improved, commercially available LWRs in the early 1990s. The Advanced Simplified Boiling Water Reactor (ASBWR) program and the AP-600 program are developing more advanced reactors with increased use of passive safety systems. It is planned that these reactors will become commercially available in the mid 1990s. The ORNL program is an exploratory research program for LWRs beyond the year 2000. Desired long-term goals for such reactors include: (1) use of only passive and inherent safety, (2) foolproof against operator errors, (3) malevolence resistance against internal sabotage and external assault and (4) walkaway safety. The acronym ''PRIME'' (Passive safety, Resilient operation, Inherent safety, Malevolence resistance, and Extended (walkaway) safety) is used to summarize these desired characteristics. Existing passive and inherent safety options are discussed in this document.

  12. Analysis of advanced european nuclear fuel cycle scenarios including transmutation and economical estimates

    SciTech Connect

    Merino Rodriguez, I.; Alvarez-Velarde, F.; Martin-Fuertes, F.

    2013-07-01

    In this work the transition from the existing Light Water Reactors (LWR) to the advanced reactors is analyzed, including Generation III+ reactors in a European framework. Four European fuel cycle scenarios involving transmutation options have been addressed. The first scenario (i.e., reference) is the current fleet using LWR technology and open fuel cycle. The second scenario assumes a full replacement of the initial fleet with Fast Reactors (FR) burning U-Pu MOX fuel. The third scenario is a modification of the second one introducing Minor Actinide (MA) transmutation in a fraction of the FR fleet. Finally, in the fourth scenario, the LWR fleet is replaced using FR with MOX fuel as well as Accelerator Driven Systems (ADS) for MA transmutation. All scenarios consider an intermediate period of GEN-III+ LWR deployment and they extend for a period of 200 years looking for equilibrium mass flows. The simulations were made using the TR-EVOL code, a tool for fuel cycle studies developed by CIEMAT. The results reveal that all scenarios are feasible according to nuclear resources demand (U and Pu). Concerning to no transmutation cases, the second scenario reduces considerably the Pu inventory in repositories compared to the reference scenario, although the MA inventory increases. The transmutation scenarios show that elimination of the LWR MA legacy requires on one hand a maximum of 33% fraction (i.e., a peak value of 26 FR units) of the FR fleet dedicated to transmutation (MA in MOX fuel, homogeneous transmutation). On the other hand a maximum number of ADS plants accounting for 5% of electricity generation are predicted in the fourth scenario (i.e., 35 ADS units). Regarding the economic analysis, the estimations show an increase of LCOE (Levelized cost of electricity) - averaged over the whole period - with respect to the reference scenario of 21% and 29% for FR and FR with transmutation scenarios respectively, and 34% for the fourth scenario. (authors)

  13. Chemical Features of Soil: Advanced Crop and Soil Science. A Course of Study.

    ERIC Educational Resources Information Center

    Miller, Larry E.

    The course of study represents the fifth of six modules in advanced crop and soil science and introduces the agriculture student to chemical features of the soil. Upon completing the four day lesson, the student will be able to: (1) list macro- and micro-nutrients, (2) define pH and its effect on plants, (3) outline Cation Exchange of the soil,…

  14. Improved best estimate plus uncertainty methodology including advanced validation concepts to license evolving nuclear reactors

    SciTech Connect

    Unal, Cetin; Williams, Brian; Mc Clure, Patrick; Nelson, Ralph A

    2010-01-01

    Many evolving nuclear energy programs plan to use advanced predictive multi-scale multi-physics simulation and modeling capabilities to reduce cost and time from design through licensing. Historically, the role of experiments was primary tool for design and understanding of nuclear system behavior while modeling and simulation played the subordinate role of supporting experiments. In the new era of multi-scale multi-physics computational based technology development, the experiments will still be needed but they will be performed at different scales to calibrate and validate models leading predictive simulations. Cost saving goals of programs will require us to minimize the required number of validation experiments. Utilization of more multi-scale multi-physics models introduces complexities in the validation of predictive tools. Traditional methodologies will have to be modified to address these arising issues. This paper lays out the basic aspects of a methodology that can be potentially used to address these new challenges in design and licensing of evolving nuclear technology programs. The main components of the proposed methodology are verification, validation, calibration, and uncertainty quantification. An enhanced calibration concept is introduced and is accomplished through data assimilation. The goal is to enable best-estimate prediction of system behaviors in both normal and safety related environments. To achieve this goal requires the additional steps of estimating the domain of validation and quantification of uncertainties that allow for extension of results to areas of the validation domain that are not directly tested with experiments, which might include extension of the modeling and simulation (M&S) capabilities for application to full-scale systems. The new methodology suggests a formalism to quantify an adequate level of validation (predictive maturity) with respect to required selective data so that required testing can be minimized for cost

  15. New data evaluation procedure including advanced background subtraction for radiography using the example of insect mandibles

    NASA Astrophysics Data System (ADS)

    Mangold, Stefan; van de Kamp, Thomas; Steininger, Ralph

    2016-05-01

    The usefulness of full field transmission spectroscopy is shown using the example of mandible of the stick insect Peruphasma schultei. An advanced data evaluation tool chain with an energy drift correction and highly reproducible automatic background correction is presented. The results show significant difference between the top and the bottom of the mandible of an adult stick insect.

  16. 24 CFR 232.254 - Withdrawal of project funds, including for repayments of advances from the borrower, operator, or...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Withdrawal of project funds, including for repayments of advances from the borrower, operator, or management agent. 232.254 Section 232... FACILITIES Contract Rights and Obligations § 232.254 Withdrawal of project funds, including for repayments...

  17. 24 CFR 232.254 - Withdrawal of project funds, including for repayments of advances from the borrower, operator, or...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Withdrawal of project funds, including for repayments of advances from the borrower, operator, or management agent. 232.254 Section 232... FACILITIES Contract Rights and Obligations § 232.254 Withdrawal of project funds, including for repayments...

  18. Clinicopathological features of aggressive B-cell lymphomas including B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell and Burkitt lymphomas: a study of 44 patients from Argentina.

    PubMed

    Bürgesser, María Virginia; Gualco, Gabriela; Diller, Ana; Natkunam, Yasodha; Bacchi, Carlos E

    2013-06-01

    Aggressive B-cell lymphomas incorporate a wide spectrum of lymphomas that pose challenges in diagnosis as well as treatment. We evaluated the clinicopathological features of 44 patients with aggressive B-cell lymphomas which were classified into 3 groups based on the World Health Organization 2008 classification as follows: including 30 cases of diffuse large B-cell lymphoma (DLBCL), 8 cases of Burkitt lymphoma (BL) and 6 cases of B-cell lymphoma, unclassifiable, with features intermediate between Burkitt lymphoma and diffuse large B-cell lymphoma (BCLU). Male predominance was observed in BL and BCLU groups and the mean age varied from 29 years in BL, 61 years in DLBCL and 70 years in BCLU. Patients with BCLU presented at more advanced stages and had a higher international prognostic index. By immunohistochemistry, they shared characteristics of both BL (including more frequent expression of SOX11) and DLBCL. FISH analyses showed three cases with more than one rearrangement: one MYC/BCL2 and two BCL2/BCL6, in addition to which one case with BCL2/IGH translocation and another with MYC rearrangement were also detected. The mean follow-up survival time of BCLU was 6.6 months, which was significantly shorter in comparison to DLBCL (31 months) and BL (30 months), respectively. The importance of recognizing this BCLU group relies on its different clinical course, poor prognosis and shorter survival than DLBCL and BL. An accurate diagnosis is critical for risk stratification and to improve therapeutic approaches and outcomes.

  19. Extrapyramidal features in advanced Down's syndrome: clinical evaluation and family history.

    PubMed Central

    Vieregge, P; Ziemens, G; Freudenberg, M; Piosinski, A; Muysers, A; Schulze, B

    1991-01-01

    Extrapyramidal, frontal release, and other neurological signs were studied in 54 demented and non-demented patients with Down's syndrome (DS). Fourteen patients were demented and five showed extrapyramidal signs, mainly of the rigid-hypokinetic spectrum and similar to Parkinsonian features in advanced Alzheimer's disease (AD). None of the non-demented patients had Parkinsonian signs. The mean age of the demented DS patients with extrapyramidal signs was significantly higher than that of the patients without. Frontal release signs were present in demented and non-demented patients. A questionnaire showed no increase in either the proportion of early- or senile-onset dementia or Parkinsonism among first- and second-degree relatives of DS patients. Parkinsonian signs appear to be present at a lower frequency in DS than in advanced AD. A speculative hypothesis about a gene dosage effect of Cu/Zn-superoxide dismutase in preventing toxic radical formation in the substantia nigra of DS patients is presented. PMID:1826326

  20. Clinical and Structural Features of Sperm Head Vacuoles in Men Included in the In Vitro Fertilization Programme

    PubMed Central

    Štrus, Jasna; Tušek Žnidarič, Magda; Knez, Katja; Vrtacnik Bokal, Eda; Virant-Klun, Irma

    2014-01-01

    The human sperm head vacuoles and their role in male infertility are still poorly understood. The aim of this study was to identify the clinical and ultrastructural features of human sperm head vacuoles in men included in the in vitro fertilization programme: men with normal (normozoospermia) and impaired sperm morphology (teratozoospermia). The sperm samples were observed under 6000-time magnification using motile sperm organelle morphology examination (MSOME). The proportion of sperm with head vacuoles was evaluated and related to the outcome of in vitro fertilization. The sperm of men with impaired sperm morphology was characterized by a higher proportion of sperm head vacuoles. The sperm head vacuoles were related to impaired semen quality (sperm concentration, motility, and morphology) but were not influenced by male factors (semen volume, height, age, weight, or body mass index). Moreover, sperm head vacuoles were related to impaired fertilization rate merely after classical in vitro fertilization (IVF), while there was no relation to pregnancy. In a subgroup of men, the sperm was fixed and observed by transmission electron microscopy (TEM). The ultrastructural study revealed that sperm head vacuoles are large nuclear indentations of various sizes and positions, packed with membranous material organized in membrane whorls (MW). PMID:24818161

  1. Neoclassical Transport Including Impurities and the Bootstrap Current in Advanced Helical Systems

    SciTech Connect

    Nishimura, Shin; Sugama, Hideo

    2004-07-15

    A recently developed method to calculate the neoclassical viscosity, diffusion, and current coefficients in general nonsymmetric toroidal plasmas by using the direct solution of the linearized drift kinetic equation with the pitch-angle-scattering collision operator is applied to impurity transport problems and bootstrap current calculations in stellarators. In this new method based on the basic idea of the so-called moment approach, the collisional momentum conservation is taken into account, and thus, it is applicable to the heat and particle diffusivity in advanced stellarators with quasi symmetry, and also to plasma flows currents, and viscosities in general nonsymmetric multispecies plasmas. In this paper, the impurity flow and the bootstrap current observed in the neoclassical internal transport barrier operation in the Compact Helical System are compared with theoretical calculations. Another topic is the benchmark test of existing analytical expressions for the bootstrap currents by comparing with numerically obtained current coefficients. The geometric factor, which is required for the current calculation based on the moment method, given by our new method is compared with these formulas.

  2. 78 FR 40508 - Advanced Energy Industries, Inc., Including On-Site Leased Workers From Mid Oregon Personnel and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... Employment and Training Administration Advanced Energy Industries, Inc., Including On-Site Leased Workers... Are Reported Through PV Powered, Currently Known as AE Solar Energy, Inc., Bend, Oregon; Amended Certification Regarding Eligibility To Apply for Worker Adjustment Assistance and Alternative Trade...

  3. 77 FR 4368 - Advanced Energy Industries, Inc., Including On-Site Leased Workers From Mid Oregon Personnel...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... energy inverters. The notice was published in the Federal Register on December 13, 2011(76 FR 77556). At... Employment and Training Administration Advanced Energy Industries, Inc., Including On-Site Leased Workers... Through PV Powered, Currently Known as AE Solar Energy, Inc. Bend, OR; Amended Certification...

  4. Advances in Small Remotely Piloted Aircraft Communications and Remote Sensing in Maritime Environments including the Arctic

    NASA Astrophysics Data System (ADS)

    McGillivary, P. A.; Borges de Sousa, J.; Wackowski, S.; Walker, G.

    2011-12-01

    Small remotely piloted aircraft have recently been used for maritime remote sensing, including launch and retrieval operations from land, ships and sea ice. Such aircraft can also function to collect and communicate data from other ocean observing system platforms including moorings, tagged animals, drifters, autonomous surface vessels (ASVs), and autonomous underwater vessels (AUVs). The use of small remotely piloted aircraft (or UASs, unmanned aerial systems) with a combination of these capabilities will be required to monitor the vast areas of the open ocean, as well as in harsh high-latitude ecosystems. Indeed, these aircraft are a key component of planned high latitude maritime domain awareness environmental data collection capabilities, including use of visible, IR and hyperspectral sensors, as well as lidar, meteorological sensors, and interferometric synthetic aperture radars (ISARs). We here first describe at-sea demonstrations of improved reliability and bandwidth of communications from ocean sensors on autonomous underwater vehicles to autonomous surface vessels, and then via remotely piloted aircraft to shore, ships and manned aircraft using Delay and Disruption Tolerant (DTN) communication protocols. DTN enables data exchange in communications-challenged environments, such as remote regions of the ocean including high latitudes where low satellite angles and auroral disturbances can be problematic. DTN provides a network architecture and application interface structured around optionally-reliable asynchronous message forwarding, with limited expectations of end-to-end connectivity and node resources. This communications method enables aircraft and surface vessels to function as data mules to move data between physically disparate nodes. We provide examples of the uses of this communication protocol for environmental data collection and data distribution with a variety of different remotely piloted aircraft in a coastal ocean environment. Next, we

  5. [Development of advanced educational programs, including research programs, for undergraduate students in National Universities: the facts in 2010].

    PubMed

    Kurosaki, Yuji; Tomioka, Yoshihisa; Santa, Tomofumi; Kitamura, Yoshihisa

    2012-01-01

    This article summarizes detailed facts obtained from the questionnaire conducted in 2010 at about 14 National Universities on the topic of "Research programs and advanced educational programs for undergraduate students". The contents of the questionnaire included: (1) Research programs based on the coalition of university and hospital and/or community pharmacy, other Graduate Schools, such as School of Medicine etc., and the University Hospital, (2) Educational systems for the achievement of research programs and their research outcomes, (3) Research programs based on pharmacist practices, (4) Ongoing advanced educational programs for undergraduate students, taking advantage of the coalition with Graduate School, School of Medicine (and Dentistry), and University Hospital. Some of the advanced educational programs outlined in this questionnaire will be carried out by our group in the coming years and the educational benefits together with associated problems shall as well be clarified. This approach will be informative for the development of the leader-oriented pharmacist programs for the college of Pharmacy.

  6. Advanced Tie Feature Matching for the Registration of Mobile Mapping Imaging Data and Aerial Imagery

    NASA Astrophysics Data System (ADS)

    Jende, P.; Peter, M.; Gerke, M.; Vosselman, G.

    2016-06-01

    Mobile Mapping's ability to acquire high-resolution ground data is opposing unreliable localisation capabilities of satellite-based positioning systems in urban areas. Buildings shape canyons impeding a direct line-of-sight to navigation satellites resulting in a deficiency to accurately estimate the mobile platform's position. Consequently, acquired data products' positioning quality is considerably diminished. This issue has been widely addressed in the literature and research projects. However, a consistent compliance of sub-decimetre accuracy as well as a correction of errors in height remain unsolved. We propose a novel approach to enhance Mobile Mapping (MM) image orientation based on the utilisation of highly accurate orientation parameters derived from aerial imagery. In addition to that, the diminished exterior orientation parameters of the MM platform will be utilised as they enable the application of accurate matching techniques needed to derive reliable tie information. This tie information will then be used within an adjustment solution to correct affected MM data. This paper presents an advanced feature matching procedure as a prerequisite to the aforementioned orientation update. MM data is ortho-projected to gain a higher resemblance to aerial nadir data simplifying the images' geometry for matching. By utilising MM exterior orientation parameters, search windows may be used in conjunction with a selective keypoint detection and template matching. Originating from different sensor systems, however, difficulties arise with respect to changes in illumination, radiometry and a different original perspective. To respond to these challenges for feature detection, the procedure relies on detecting keypoints in only one image. Initial tests indicate a considerable improvement in comparison to classic detector/descriptor approaches in this particular matching scenario. This method leads to a significant reduction of outliers due to the limited availability

  7. Proposal for therapeutic approach based on prognostic factors including morphometric and flow-cytometric features in stage III-IV ovarian cancer.

    PubMed

    Wils, J; van Geuns, H; Baak, J

    1988-05-01

    In 73 patients with International Federation of Gynecology and Obstetrics (FIGO) Stage III and IV ovarian cancer the prognostic significance of morphometric and flow-cytometric features has been evaluated in comparison with more commonly used prognostic factors such as stage and tumor mass. Single features associated with prognosis were as follows: FIGO stage, bulky disease, mean and standard deviation of nuclear area, cellular DNA content, mitotic activity index, and volume percentage epithelium. Multivariate analysis showed that the most significant prognostic combination of features consisted of mean nuclear area, presence or absence of bulky disease, and FIGO stage (in sequence of decreasing importance; Mantel-Cox = 23.07, P less than 0.00001). On the basis of these factors patients with a poor prognosis can be identified. On the other hand two features were associated with an excellent prognosis namely a low mitotic index and a low-volume percentage epithelium. It is concluded that morphometric and flow-cytometric analysis in combination with clinical features can provide significant information to predict the prognosis of patients with advanced ovarian cancer treated with debulking surgery and platinum-based chemotherapy. On the basis of our data a tentative proposal for future therapeutic approaches is made.

  8. Evaluation and study of advanced optical contamination, deposition, measurement, and removal techniques. [including computer programs and ultraviolet reflection analysis

    NASA Technical Reports Server (NTRS)

    Linford, R. M. F.; Allen, T. H.; Dillow, C. F.

    1975-01-01

    A program is described to design, fabricate and install an experimental work chamber assembly (WCA) to provide a wide range of experimental capability. The WCA incorporates several techniques for studying the kinetics of contaminant films and their effect on optical surfaces. It incorporates the capability for depositing both optical and contaminant films on temperature-controlled samples, and for in-situ measurements of the vacuum ultraviolet reflectance. Ellipsometer optics are mounted on the chamber for film thickness determinations, and other features include access ports for radiation sources and instrumentation. Several supporting studies were conducted to define specific chamber requirements, to determine the sensitivity of the measurement techniques to be incorporated in the chamber, and to establish procedures for handling samples prior to their installation in the chamber. A bibliography and literature survey of contamination-related articles is included.

  9. Probing structures of nanomaterials using advanced electron microscopy methods, including aberration-corrected electron microscopy at the Angstrom scale.

    PubMed

    Gai, Pratibha L; Yoshida, Kenta; Shute, Carla; Jia, Xiaoting; Walsh, Michael; Ward, Michael; Dresselhaus, Mildred S; Weertman, Julia R; Boyes, Edward D

    2011-07-01

    Structural and compositional studies of nanomaterials of technological importance have been carried out using advanced electron microscopy methods, including aberration-corrected transmission electron microscopy (AC-TEM), AC-high angle annular dark field scanning TEM (AC-HAADF-STEM), AC-energy filtered TEM, electron-stimulated energy dispersive spectroscopy in the AC-(S)TEM and high-resolution TEM (HRTEM) with scanning tunneling microscopy (STM) holder. The AC-EM data reveal improvements in resolution and minimization in image delocalization. A JEOL 2200FS double-AC field emission gun TEM/STEM operating at 200 kV in the Nanocentre at the University of York has been used to image single metal atoms on crystalline supports in catalysts, grain boundaries in nanotwinned metals, and nanostructures of tetrapods. Joule heating studies using HRTEM integrated with an STM holder reveal in situ crystallization and edge reconstruction in graphene. Real-time in situ AC-HAADF-STEM studies at elevated temperatures are described. Dynamic in-column energy filtering in an AC environment provides an integral new approach to perform dynamic in situ studies with aberration correction. The new results presented here open up striking new opportunities for atomic scale studies of nanomaterials and indicate future development directions.

  10. Cohesion Features in ESL Reading: Comparing Beginning, Intermediate and Advanced Textbooks

    ERIC Educational Resources Information Center

    Plakans, Lia; Bilki, Zeynep

    2016-01-01

    This study of English as a second language (ESL) reading textbooks investigates cohesion in reading passages from 27 textbooks. The guiding research questions were whether and how cohesion differs across textbooks written for beginning, intermediate, and advanced second language readers. Using a computational tool called Coh-Metrix, textual…

  11. Variable stream control engine concept for advanced supersonic aircraft: Features and benefits

    NASA Technical Reports Server (NTRS)

    Howlett, R. A.

    1976-01-01

    The Variable Stream Control Engine is studied for advanced supersonic cruise aircraft. Significant environmental and performance improvements relative to first generation supersonic turbojet engines are cited. Two separate flow streams, each with independent burner and nozzle systems are incorporated within the engine. By unique control of the exhaust temperatures and velocities in two coannular streams, significant reduction in jet noise is obtained.

  12. Special Features of the Advanced Loans Module of the ABCD Integrated Library System

    ERIC Educational Resources Information Center

    de Smet, Egbert

    2011-01-01

    Purpose: The "advanced loans" module of the relatively new library software, ABCD, is an addition to the normal loans module and it offers a "generic transaction decision-making engine" functionality. The module requires extra installation effort and parameterisation, so this article aims to explain to the many potentially interested libraries,…

  13. TU-C-12A-09: Modeling Pathologic Response of Locally Advanced Esophageal Cancer to Chemo-Radiotherapy Using Quantitative PET/CT Features, Clinical Parameters and Demographics

    SciTech Connect

    Zhang, H; Chen, W; Kligerman, S; D’Souza, W; Suntharalingam, M; Lu, W; Tan, S; Kim, G

    2014-06-15

    Purpose: To develop predictive models using quantitative PET/CT features for the evaluation of tumor response to neoadjuvant chemo-radiotherapy (CRT) in patients with locally advanced esophageal cancer. Methods: This study included 20 patients who underwent tri-modality therapy (CRT + surgery) and had {sup 18}F-FDG PET/CT scans before initiation of CRT and 4-6 weeks after completion of CRT but prior to surgery. Four groups of tumor features were examined: (1) conventional PET/CT response measures (SUVmax, tumor diameter, etc.); (2) clinical parameters (TNM stage, histology, etc.) and demographics; (3) spatial-temporal PET features, which characterize tumor SUV intensity distribution, spatial patterns, geometry, and associated changes resulting from CRT; and (4) all features combined. An optimal feature set was identified with recursive feature selection and cross-validations. Support vector machine (SVM) and logistic regression (LR) models were constructed for prediction of pathologic tumor response to CRT, using cross-validations to avoid model over-fitting. Prediction accuracy was assessed via area under the receiver operating characteristic curve (AUC), and precision was evaluated via confidence intervals (CIs) of AUC. Results: When applied to the 4 groups of tumor features, the LR model achieved AUCs (95% CI) of 0.57 (0.10), 0.73 (0.07), 0.90 (0.06), and 0.90 (0.06). The SVM model achieved AUCs (95% CI) of 0.56 (0.07), 0.60 (0.06), 0.94 (0.02), and 1.00 (no misclassifications). Using spatial-temporal PET features combined with conventional PET/CT measures and clinical parameters, the SVM model achieved very high accuracy (AUC 1.00) and precision (no misclassifications), significantly better than using conventional PET/CT measures or clinical parameters and demographics alone. For groups with a large number of tumor features (groups 3 and 4), the SVM model achieved significantly higher accuracy than the LR model. Conclusion: The SVM model using all features

  14. Pediatric Cerebellar Tumors: Emerging Imaging Techniques and Advances in Understanding of Genetic Features.

    PubMed

    Choudhri, Asim F; Siddiqui, Adeel; Klimo, Paul

    2016-08-01

    Cerebellar tumors are the most common group of solid tumors in children. MR imaging provides an important role in characterization of these lesions, surgical planning, and postsurgical surveillance. Preoperative imaging can help predict the histologic subtype of tumors, which can provide guidance for surgical planning. Beyond histology, pediatric brain tumors are undergoing new classification schemes based on genetic features. Intraoperative MR imaging has emerged as an important tool in the surgical management of pediatric brain tumors. Effective understanding of the imaging features of pediatric cerebellar tumors can benefit communication with neurosurgeons and neuro-oncologists and can improve patient management.

  15. Pediatric Cerebellar Tumors: Emerging Imaging Techniques and Advances in Understanding of Genetic Features.

    PubMed

    Choudhri, Asim F; Siddiqui, Adeel; Klimo, Paul

    2016-08-01

    Cerebellar tumors are the most common group of solid tumors in children. MR imaging provides an important role in characterization of these lesions, surgical planning, and postsurgical surveillance. Preoperative imaging can help predict the histologic subtype of tumors, which can provide guidance for surgical planning. Beyond histology, pediatric brain tumors are undergoing new classification schemes based on genetic features. Intraoperative MR imaging has emerged as an important tool in the surgical management of pediatric brain tumors. Effective understanding of the imaging features of pediatric cerebellar tumors can benefit communication with neurosurgeons and neuro-oncologists and can improve patient management. PMID:27423803

  16. Study of Cost Effective Large Advanced Pressurized Water Reactors that Employ Passive Safety Features

    SciTech Connect

    Winters, J. W.; Corletti, M. M.; Hayashi, Y.

    2003-11-12

    A report of DOE sponsored portions of AP1000 Design Certification effort. On December 16, 1999, The United States Nuclear Regulatory Commission issued Design Certification of the AP600 standard nuclear reactor design. This culminated an 8-year review of the AP600 design, safety analysis and probabilistic risk assessment. The AP600 is a 600 MWe reactor that utilizes passive safety features that, once actuated, depend only on natural forces such as gravity and natural circulation to perform all required safety functions. These passive safety systems result in increased plant safety and have also significantly simplified plant systems and equipment, resulting in simplified plant operation and maintenance. The AP600 meets NRC deterministic safety criteria and probabilistic risk criteria with large margins. A summary comparison of key passive safety system design features is provided in Table 1. These key features are discussed due to their importance in affecting the key thermal-hydraulic phenomenon exhibited by the passive safety systems in critical areas. The scope of some of the design changes to the AP600 is described. These changes are the ones that are important in evaluating the passive plant design features embodied in the certified AP600 standard plant design. These design changes are incorporated into the AP1000 standard plant design that Westinghouse is certifying under 10 CFR Part 52. In conclusion, this report describes the results of the representative design certification activities that were partially supported by the Nuclear Energy Research Initiative. These activities are unique to AP1000, but are representative of research activities that must be driven to conclusion to realize successful licensing of the next generation of nuclear power plants in the United States.

  17. Advances in feature selection methods for hyperspectral image processing in food industry applications: a review.

    PubMed

    Dai, Qiong; Cheng, Jun-Hu; Sun, Da-Wen; Zeng, Xin-An

    2015-01-01

    There is an increased interest in the applications of hyperspectral imaging (HSI) for assessing food quality, safety, and authenticity. HSI provides abundance of spatial and spectral information from foods by combining both spectroscopy and imaging, resulting in hundreds of contiguous wavebands for each spatial position of food samples, also known as the curse of dimensionality. It is desirable to employ feature selection algorithms for decreasing computation burden and increasing predicting accuracy, which are especially relevant in the development of online applications. Recently, a variety of feature selection algorithms have been proposed that can be categorized into three groups based on the searching strategy namely complete search, heuristic search and random search. This review mainly introduced the fundamental of each algorithm, illustrated its applications in hyperspectral data analysis in the food field, and discussed the advantages and disadvantages of these algorithms. It is hoped that this review should provide a guideline for feature selections and data processing in the future development of hyperspectral imaging technique in foods.

  18. Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma

    PubMed Central

    Goyal, Lipika; Govindan, Aparna; Sheth, Rahul A.; Nardi, Valentina; Blaszkowsky, Lawrence S.; Faris, Jason E.; Clark, Jeffrey W.; Ryan, David P.; Kwak, Eunice L.; Allen, Jill N.; Murphy, Janet E.; Saha, Supriya K.; Hong, Theodore S.; Wo, Jennifer Y.; Ferrone, Cristina R.; Tanabe, Kenneth K.; Chong, Dawn Q.; Deshpande, Vikram; Borger, Darrell R.; Iafrate, A. John; Bardeesy, Nabeel; Zheng, Hui

    2015-01-01

    Background. Conflicting data exist regarding the prognostic impact of the isocitrate dehydrogenase (IDH) mutation in intrahepatic cholangiocarcinoma (ICC), and limited data exist in patients with advanced-stage disease. Similarly, the clinical phenotype of patients with advanced IDH mutant (IDHm) ICC has not been characterized. In this study, we report the correlation of IDH mutation status with prognosis and clinicopathologic features in patients with advanced ICC. Methods. Patients with histologically confirmed advanced ICC who underwent tumor mutational profiling as a routine part of their care between 2009 and 2014 were evaluated. Clinical and pathological data were collected by retrospective chart review for patients with IDHm versus IDH wild-type (IDHwt) ICC. Pretreatment tumor volume was calculated on computed tomography or magnetic resonance imaging. Results. Of the 104 patients with ICC who were evaluated, 30 (28.8%) had an IDH mutation (25.0% IDH1, 3.8% IDH2). The median overall survival did not differ significantly between IDHm and IDHwt patients (15.0 vs. 20.1 months, respectively; p = .17). The pretreatment serum carbohydrate antigen 19-9 (CA19-9) level in IDHm and IDHwt patients was 34.5 and 118.0 U/mL, respectively (p = .04). Age at diagnosis, sex, histologic grade, and pattern of metastasis did not differ significantly by IDH mutation status. Conclusion. The IDH mutation was not associated with prognosis in patients with advanced ICC. The clinical phenotypes of advanced IDHm and IDHwt ICC were similar, but patients with IDHm ICC had a lower median serum CA19-9 level at presentation. Implications for Practice: Previous studies assessing the prognostic impact of the isocitrate dehydrogenase (IDH) gene mutation in intrahepatic cholangiocarcinoma (ICC) mainly focused on patients with early-stage disease who have undergone resection. These studies offer conflicting results. The target population for clinical trials of IDH inhibitors is patients with

  19. [Advances in the research of clinical features and treatment of ammonia burns].

    PubMed

    Wu, Guosheng; Xiao, Shichu; Sun, Yu; Ji, Shizhao; Xia, Zhaofan

    2015-02-01

    Ammonia is commonly used in industry and agriculture. It is also one of the most frequently accidentally spilled chemicals. Exposure to ammonia can cause severe cutaneous burn or freezing injury, ocular injury, and inhalation injury, among them inhalation injury is the most lethal one. Although the diagnosis and treatment of ammonia burns have been improved, the long-term prognosis is not satisfactory. In this article, we reviewed the literature concerning ammonia burns, in order to summarize the clinical features and treatment of such injury.

  20. Magnetic Feature Tracking in the SDO Era: Past Sacrifices, Recent Advances, and Future Possibilities

    NASA Astrophysics Data System (ADS)

    Lamb, D. A.; DeForest, C. E.; Van Kooten, S.

    2014-12-01

    When implementing computer vision codes, a common reaction to the high angular resolution and the high cadence of SDO's image products has been to reduce the resolution and cadence of the data so that it "looks like" SOHO data. This can be partially justified on physical grounds: if the phenomenon that a computer vision code is trying to detect was characterized in low-resolution, low cadence data, then the higher quality data may not be needed. But sacrificing at least two, and sometimes all four main advantages of SDO's imaging data (the other two being a higher duty cycle and additional data products) threatens to also discard the perhaps more subtle discoveries waiting to be made: a classic baby-with-the-bath-water situation. In this presentation, we discuss some of the sacrifices made in implementing SWAMIS-EF, an automatic emerging magnetic flux region detection code for SDO/HMI, and how those sacrifices simultaneously simplified and complicated development of the code. SWAMIS-EF is a feature-finding code, and we will describe some situations and analyses in which a feature-finding code excels, and some in which a different type of algorithm may produce more favorable results. In particular, because the solar magnetic field is irreducibly complex at the currently observed spatial scales, searching for phenomena such as flux emergence using even semi-strict physical criteria often leads to large numbers of false or missed detections. This undesirable behavior can be mitigated by relaxing the imposed physical criteria, but here too there are tradeoffs: decreased numbers of missed detections may increase the number of false detections if the selection criteria are not both sensitive and specific to the searched-for phenomenon. Finally, we describe some recent steps we have taken to overcome these obstacles, by fully embracing the high resolution, high cadence SDO data, optimizing and partially parallelizing our existing code as a first step to allow fast

  1. Pancreaticobiliary reflux as a high-risk factor for biliary malignancy: Clinical features and diagnostic advancements

    PubMed Central

    Sugita, Reiji

    2015-01-01

    Pancreaticobiliary junction is composed of complex structure with which biliary duct and pancreatic duct assemble and go out into the ampulla of Vater during duodenum wall surrounding the sphincter of Oddi. Although the sphincter of Oddi functionally prevents the reflux of pancreatic juice, pancreaticobiliary reflux (PBR) occurs when function of the sphincter of Oddi halt. The anatomically abnormal junction is termed pancreaticobiliary maljunction (PBM) and is characterized by pancreatic and bile ducts joining outside of the duodenal wall. PBM is an important anatomical finding because many studies have revealed that biliary malignancies are related due to the carcinogenetic effect of the pancreatic back flow on the biliary mucosa. On the other hand, several studies have been published on the reflux of pancreatic juice into the bile duct without morphological PBM, and the correlation of such cases with biliary diseases, especially biliary malignancies, is drawing considerable attention. Although it has long been possible to diagnose PBM by various imaging modalities, PBR without PBM has remained difficult to assess. Therefore, the pathological features of PBR without PBM have not been yet fully elucidated. Lately, a new method of diagnosing PBR without PBM has appeared, and the features of PBR without PBM should soon be better understood. PMID:26167246

  2. The DARPA compact superconducting x-ray lithography source features. [Defense Advanced Research Projects Agency (DARPA)

    SciTech Connect

    Heese, R. ); Kalsi, S. ); Leung, E. . Space Systems Div.)

    1991-01-01

    Under DARPA sponsorship, a compact Superconducting X-ray Lithography Source (SXLS) is being designed and built by the Brookhaven National Laboratory (BNL) with industry participation from Grumman Corporation and General Dynamics. This source is optimized for lithography work for sub-micron high density computer chips, and is about the size of a billiard table (1.5 m {times} 4.0 m). The machine has a racetrack configuration with two 180{degree} bending magnets being designed and built by General Dynamics under a subcontract with Grumman Corporation. The machine will have 18 photon ports which would deliver light peaked at a wave length of 10 Angstroms. Grumman is commercializing the SXLS device and plans to book orders for delivery of industrialized SXLS (ISXLS) versions in 1995. This paper will describe the major features of this device. The commercial machine will be equipped with a fully automated user-friendly control systems, major features of which are already working on a compact warm dipole ring at BNL. This ring has normal dipole magnets with dimensions identical to the SXLS device, and has been successfully commissioned. 4 figs., 1 tab.

  3. Marfanoid habitus, inguinal hernia, advanced bone age, and distinctive facial features: a new collagenopathy?

    PubMed

    Mégarbané, André; Hanna, Nadine; Chouery, Eliane; Jalkh, Nadine; Mehawej, Cybel; Boileau, Catherine

    2012-05-01

    We report on two sibs, a girl, and a boy, with tall stature, long, and triangular faces, prominent foreheads with high frontal hairlines, telecanthus, downward slanting of the palpebral fissures, ptosis of the eyelids, everted lower eyelids, large ears, long noses, full, and everted vermilions, highly arched and narrow palates, tooth crowding, thin and long uvulae, coloboma of the alae, hyperextensible joints, long digits, positive thumb signs, flat feet, slightly diminished muscle strength, myopia, astigmatia, inguinal hernia, and vesical diverticula. Total body X-rays showed the presence of advanced bone age in both sibs and bilateral hallux valgus in the girl. Array-CGH did not reveal any pathological CNV. Molecular analysis of FBN1, FBN2, TGFBR1, TGFBR2, and CHST14 gene was normal, and SNP linkage analysis excluded more candidate genes. Differential diagnoses and the possibility that we might be reporting on a hitherto unreported syndrome are discussed.

  4. Advanced Hybrid Spacesuit Concept Featuring Integrated Open Loop and Closed Loop Ventilation Systems

    NASA Technical Reports Server (NTRS)

    Daniel, Brian A.; Fitzpatrick, Garret R.; Gohmert, Dustin M.; Ybarra, Rick M.; Dub, Mark O.

    2013-01-01

    A document discusses the design and prototype of an advanced spacesuit concept that integrates the capability to function seamlessly with multiple ventilation system approaches. Traditionally, spacesuits are designed to operate both dependently and independently of a host vehicle environment control and life support system (ECLSS). Spacesuits that operate independent of vehicle-provided ECLSS services must do so with equipment selfcontained within or on the spacesuit. Suits that are dependent on vehicle-provided consumables must remain physically connected to and integrated with the vehicle to operate properly. This innovation is the design and prototype of a hybrid spacesuit approach that configures the spacesuit to seamlessly interface and integrate with either type of vehicular systems, while still maintaining the ability to function completely independent of the vehicle. An existing Advanced Crew Escape Suit (ACES) was utilized as the platform from which to develop the innovation. The ACES was retrofitted with selected components and one-off items to achieve the objective. The ventilation system concept was developed and prototyped/retrofitted to an existing ACES. Components were selected to provide suit connectors, hoses/umbilicals, internal breathing system ducting/ conduits, etc. The concept utilizes a lowpressure- drop, high-flow ventilation system that serves as a conduit from the vehicle supply into the suit, up through a neck seal, into the breathing helmet cavity, back down through the neck seal, out of the suit, and returned to the vehicle. The concept also utilizes a modified demand-based breathing system configured to function seamlessly with the low-pressure-drop closed-loop ventilation system.

  5. The removal of organic precursors of DBPs during three advanced water treatment processes including ultrafiltration, biofiltration, and ozonation.

    PubMed

    Zha, Xiao-Song; Ma, Lu-Ming; Wu, Jin; Liu, Yan

    2016-08-01

    The removal efficiency of organic matter, the formation potential of trihalomethanes (THMFP), and the formation potential of haloacetic acids (HAAFP) in each unit of three advanced treatment processes were investigated in this paper. The molecular weight distribution and the components of organic matter in water samples were also determined to study the transformation of organic matter during these advanced treatments. Low-molecular-weight matter was the predominant fraction in raw water, and it could not be removed effectively by ultrafiltration and biofiltration. The dominant species of disinfection by-product formation potential (DBPFP) in raw water were chloroform and monochloroacetic acid (MCAA), with average concentrations of 107.3 and 125.9 μg/L, respectively. However, the formation potential of chloroform and MCAA decreased to 36.2 and 11.5 μg/L after ultrafiltration. Similarly, biological pretreatment obtained high removal efficiency for DBPFP. The total THMFP decreased from 173.8 to 81.8 μg/L, and the total HAAFP decreased from 211.9 to 84.2 μg/L. Separate ozonation had an adverse effect on DBPFP, especially for chlorinated HAAFP. Numerous low-molecular-weight compounds such as aldehydes, ketones, and alcohols were generated during the ozonation, which have been proven to be important precursors of HAAs. However, the ozonation/biological activated carbon (BAC) combined process had a better removal efficiency for DBPFP. The total DBPFP decreased remarkably from 338.7 to 113.3 μg/L after the O3/BAC process, far below the separated BAC of process B (189.1 μg/L). PMID:27180835

  6. Advanced theoretical and experimental studies in automatic control and information systems. [including mathematical programming and game theory

    NASA Technical Reports Server (NTRS)

    Desoer, C. A.; Polak, E.; Zadeh, L. A.

    1974-01-01

    A series of research projects is briefly summarized which includes investigations in the following areas: (1) mathematical programming problems for large system and infinite-dimensional spaces, (2) bounded-input bounded-output stability, (3) non-parametric approximations, and (4) differential games. A list of reports and papers which were published over the ten year period of research is included.

  7. Advances with the new AIMS fab 193 2nd generation: a system for the 65 nm node including immersion

    NASA Astrophysics Data System (ADS)

    Zibold, Axel M.; Poortinga, E.; Doornmalen, H. v.; Schmid, R.; Scherubl, T.; Harnisch, W.

    2005-06-01

    The Aerial Image Measurement System, AIMS, for 193nm lithography emulation is established as a standard for the rapid prediction of wafer printability for critical structures including dense patterns and defects or repairs on masks. The main benefit of AIMS is to save expensive image qualification consisting of test wafer exposures followed by wafer CD-SEM resist or wafer analysis. By adjustment of numerical aperture (NA), illumination type and partial coherence (σ) to match any given stepper/ scanner, AIMS predicts the printability of 193nm reticles such as binary with, or without OPC and phase shifting. A new AIMS fab 193 second generation system with a maximum NA of 0.93 is now available. Improvements in field uniformity, stability over time, measurement automation and higher throughput meet the challenging requirements of the 65nm node. A new function, "Global CD Map" can be applied to automatically measure and analyse the global CD uniformity of repeating structures across a reticle. With the options of extended depth-of-focus (EDOF) software and the upcoming linear polarisation capability in the illumination the new AIMS fab 193 second generation system is able to cover both dry and immersion requirements for NA < 1. Rigorous simulations have been performed to study the effects of polarisation for imaging by comparing the aerial image of the AIMS to the resist image of the scanner.

  8. A Case of Long-term Survival of Advanced Paratesticular Rhabdomyosarcoma Treated With a Multimodal Therapy Including a Combination of Cyclophosphamide, Vincristine, Doxorubicin and Dacarbazine.

    PubMed

    Isono, Makoto; Sato, Akinori; Asano, Tomohiko

    2016-07-01

    There is no established treatment for advanced rhabdomyosarcoma (RMS) with metastases at the time of diagnosis. A 17-year-old male was referred to our hospital because of a right scrotal mass. Computed tomography showed multiple lung metastases with pleural effusion and retroperitoneal lymph node metastasis, and bone scintigraphy revealed multiple bone metastases. Right high orchiectomy was performed and the tumor was diagnosed as paratesticular embryonal RMS. He was treated with a multimodal therapy including 17 cycles of combination chemotherapy consisting of cyclophosphamide, vincristine, doxorubicin and dacarbazine (CYVADIC) and achieved a long-term survival of 4 years. PMID:27335778

  9. Multimodal Therapy including Yttrium-90 Radioembolization as a Bridging Therapy to Liver Transplantation for a Huge and Locally Advanced Intrahepatic Cholangiocarcinoma.

    PubMed

    Rayar, Michel; Levi Sandri, Giovanni Battista; Houssel-Debry, Pauline; Camus, Christophe; Sulpice, Laurent; Boudjema, Karim

    2016-09-01

    Treatment of intrahepatic cholangiocarcinoma remains a major challenge. For an unresectable lesion without extrahepatic spread, liver transplantation could be a potential solution but it is still associated with poor oncologic results owing to the absence of effective neoadjuvant treatment. We report the case of a young man with locally advanced intrahepatic cholangiocarcinoma presenting with multiple intrahepatic metastases and vascular structure involvement. The lesion was significantly downstaged by a multimodal therapy including intra-arterial Yttrium-90 radioembolization, systemic chemotherapy and external radiotherapy, allowing liver transplantation. Three years after the procedure, oncologic outcome is excellent with no sign of recurrence. Multimodal therapy including Yttrium-90 radioembolization could be relevant as neoadjuvant treatment before liver transplantation for unresectable intrahepatic cholangiocarcinoma. PMID:27689207

  10. Clinical features and hyperplastic patterns of parathyroid glands in hemodialysis patients with advanced secondary hyperparathyroidism refractory to maxacalcitol treatment and required parathyroidectomy.

    PubMed

    Tominaga, Yoshihiro; Matsuoka, Susumu; Sato, Tetsuhiko; Uno, Nobuyuki; Goto, Norihiko; Katayama, Akio; Haba, Toshihito

    2007-08-01

    We have previously suggested that when parathyroid glands progress to nodular hyperplasia, secondary hyperparathyroidism (2HPT) may be refractory to medical treatments, including treatment with Maxacalcitol (OCT). In the present study we evaluated the clinical features and hyperplastic patterns of parathyroid glands in patients who underwent parathyroidectomy (PTx) after being withdrawn from OCT. One hundred and eighty-seven advanced 2HPT patients who had been withdrawn from OCT and required PTx were enrolled. At the start of OCT treatment, the patients had a mean age of 55.3 years and had been receiving hemodialysis (HD) for a mean period of 149 months. At the start of OCT treatment and at PTx, the mean intact PTH (i-PTH) levels were 772.8 +/- 446.0 and 855.5 +/- 420.5 pg/mL, respectively. The main reasons for withdrawal of OCT treatment were persistently high PTH (n = 148), hypercalcemia (n = 79), hyperphosphatemia (n = 65), and progressive symptoms (n = 60). We classified the parathyroid glands by hyperplastic pattern into four categories: diffuse hyperplastic gland (D), early nodularity in diffuse hyperplastic gland (EN), nodular hyperplastic gland (N), and single nodular gland (SN). The mean total excised gland weight was 2592.6 mg. Out of a total of 706 glands, 118 were classified as D, 66 as EN, 436 as N, and 86 as SN. All patients had at least one nodular hyperplastic gland or single nodular gland. The mean number of nodular hyperplastic glands and/or single nodular glands was 2.9. All hemodialysis patients with advanced OCT-refractory 2HPT who underwent PTx had at least one nodular hyperplastic gland or single nodular gland.

  11. Nutritional status and feeding-tube placement in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy-based larynx preservation program.

    PubMed

    Bozec, Alexandre; Benezery, Karen; Chamorey, Emmanuel; Ettaiche, Marc; Vandersteen, Clair; Dassonville, Olivier; Poissonnet, Gilles; Riss, Jean-Christophe; Hannoun-Lévi, Jean-Michel; Chand, Marie-Eve; Leysalle, Axel; Saada, Esma; Sudaka, Anne; Haudebourg, Juliette; Hebert, Christophe; Falewee, Marie-Noelle; Demard, François; Santini, José; Peyrade, Frédéric

    2016-09-01

    The objective of the study is to evaluate the nutritional status and determine its impact on clinical outcomes in patients with locally advanced hypopharyngeal cancer included in an induction chemotherapy (ICT)-based larynx preservation program without prophylactic feeding-tube placement. All patients with locally advanced (T3/4, N0-3, M0) hypopharyngeal squamous cell carcinoma, technically suitable for total pharyngolaryngectomy, treated by docetaxel, cisplatin and 5-fluorouracil (TPF)-ICT for larynx preservation at our institution between 2004 and 2013, were included in this retrospective study. Patients' nutritional status was closely monitored. Enteral nutrition was used if and when a patient was unable to sustain per-oral nutrition and hydration. The impact of nutritional status on clinical outcomes was investigated in univariate and multivariate analysis. A total of 53 patients (42 men and 11 women, mean age = 58.6 ± 8.2 years) were included in this study. Six (11.3 %) patients had lost more than 10 % of their usual body weight before therapy. Compared with patients' usual weight, the mean maximum patient weight loss during therapeutic management was 8.7 ± 4.5 kg. Enteral nutrition was required in 17 patients (32 %). We found no influence of the tested nutritional status-related factors on response to ICT, toxicity of ICT, overall, cause-specific and recurrence-free survival, and on post-therapeutic swallowing outcome. Maximum weight loss was significantly associated with a higher risk of enteral tube feeding during therapy (p = 0.03) and of complications (grade ≥3, p = 0.006) during RT. Without prophylactic feeding-tube placement, approximately one-third of the patients required enteral nutrition. There was no significant impact of nutritional status on oncologic or functional outcomes.

  12. High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phenotype Correlation.

    PubMed

    Rojnueangnit, Kitiwan; Xie, Jing; Gomes, Alicia; Sharp, Angela; Callens, Tom; Chen, Yunjia; Liu, Ying; Cochran, Meagan; Abbott, Mary-Alice; Atkin, Joan; Babovic-Vuksanovic, Dusica; Barnett, Christopher P; Crenshaw, Melissa; Bartholomew, Dennis W; Basel, Lina; Bellus, Gary; Ben-Shachar, Shay; Bialer, Martin G; Bick, David; Blumberg, Bruce; Cortes, Fanny; David, Karen L; Destree, Anne; Duat-Rodriguez, Anna; Earl, Dawn; Escobar, Luis; Eswara, Marthanda; Ezquieta, Begona; Frayling, Ian M; Frydman, Moshe; Gardner, Kathy; Gripp, Karen W; Hernández-Chico, Concepcion; Heyrman, Kurt; Ibrahim, Jennifer; Janssens, Sandra; Keena, Beth A; Llano-Rivas, Isabel; Leppig, Kathy; McDonald, Marie; Misra, Vinod K; Mulbury, Jennifer; Narayanan, Vinodh; Orenstein, Naama; Galvin-Parton, Patricia; Pedro, Helio; Pivnick, Eniko K; Powell, Cynthia M; Randolph, Linda; Raskin, Salmo; Rosell, Jordi; Rubin, Karol; Seashore, Margretta; Schaaf, Christian P; Scheuerle, Angela; Schultz, Meredith; Schorry, Elizabeth; Schnur, Rhonda; Siqveland, Elizabeth; Tkachuk, Amanda; Tonsgard, James; Upadhyaya, Meena; Verma, Ishwar C; Wallace, Stephanie; Williams, Charles; Zackai, Elaine; Zonana, Jonathan; Lazaro, Conxi; Claes, Kathleen; Korf, Bruce; Martin, Yolanda; Legius, Eric; Messiaen, Ludwine

    2015-11-01

    Neurofibromatosis type 1 (NF1) is one of the most frequent genetic disorders, affecting 1:3,000 worldwide. Identification of genotype-phenotype correlations is challenging because of the wide range clinical variability, the progressive nature of the disorder, and extreme diversity of the mutational spectrum. We report 136 individuals with a distinct phenotype carrying one of five different NF1 missense mutations affecting p.Arg1809. Patients presented with multiple café-au-lait macules (CALM) with or without freckling and Lisch nodules, but no externally visible plexiform neurofibromas or clear cutaneous neurofibromas were found. About 25% of the individuals had Noonan-like features. Pulmonic stenosis and short stature were significantly more prevalent compared with classic cohorts (P < 0.0001). Developmental delays and/or learning disabilities were reported in over 50% of patients. Melanocytes cultured from a CALM in a segmental NF1-patient showed two different somatic NF1 mutations, p.Arg1809Cys and a multi-exon deletion, providing genetic evidence that p.Arg1809Cys is a loss-of-function mutation in the melanocytes and causes a pigmentary phenotype. Constitutional missense mutations at p.Arg1809 affect 1.23% of unrelated NF1 probands in the UAB cohort, therefore this specific NF1 genotype-phenotype correlation will affect counseling and management of a significant number of patients. PMID:26178382

  13. Clinical and pathological features of Burkitt lymphoma showing expression of BCL2--an analysis including gene expression in formalin-fixed paraffin-embedded tissue.

    PubMed

    Masqué-Soler, Neus; Szczepanowski, Monika; Kohler, Christian W; Aukema, Sietse M; Nagel, Inga; Richter, Julia; Siebert, Reiner; Spang, Rainer; Burkhardt, Birgit; Klapper, Wolfram

    2015-11-01

    The differential diagnosis between Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) can be challenging. BL has been reported to express less BCL2 than DLBCL, but this issue has not been analysed systematically. BL expressing BCL2 can be considered to be MYC/BCL2 co-expressors, a feature that is associated with poorer outcome in DLBCL but that has not been correlated with outcome in BL so far. We analysed the expression of BCL2 in 150 cases of conventionally diagnosed BL using two different BCL2 antibodies. BCL2 expression was detected in 23% of the cases, though the expression varied in intensity and number of positive cells. We did not detect any relevant differences in clinical presentation and outcome between BCL2-positive and BCL2-negative BL in a subgroup of 43 cases for which detailed clinical data were available. An independent cohort of 17 BL with expression of BCL2 were analysed molecularly, with 13 of 17 cases classified as molecularly defined BL (Burkitt Lymphoma) using gene expression profiling on formalin-fixed paraffin-embedded tissues. The four lymphomas diagnosed molecularly as intermediates did not differ in clinical presentation and outcome from molecularly defined BL. PMID:26218299

  14. High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype–Phenotype Correlation

    PubMed Central

    Rojnueangnit, Kitiwan; Xie, Jing; Gomes, Alicia; Sharp, Angela; Callens, Tom; Chen, Yunjia; Liu, Ying; Cochran, Meagan; Abbott, Mary‐Alice; Atkin, Joan; Babovic‐Vuksanovic, Dusica; Barnett, Christopher P.; Crenshaw, Melissa; Bartholomew, Dennis W.; Basel, Lina; Bellus, Gary; Ben‐Shachar, Shay; Bialer, Martin G.; Bick, David; Blumberg, Bruce; Cortes, Fanny; David, Karen L.; Destree, Anne; Duat‐Rodriguez, Anna; Earl, Dawn; Escobar, Luis; Eswara, Marthanda; Ezquieta, Begona; Frayling, Ian M.; Frydman, Moshe; Gardner, Kathy; Gripp, Karen W.; Hernández‐Chico, Concepcion; Heyrman, Kurt; Ibrahim, Jennifer; Janssens, Sandra; Keena, Beth A; Llano‐Rivas, Isabel; Leppig, Kathy; McDonald, Marie; Misra, Vinod K.; Mulbury, Jennifer; Narayanan, Vinodh; Orenstein, Naama; Galvin‐Parton, Patricia; Pedro, Helio; Pivnick, Eniko K.; Powell, Cynthia M.; Randolph, Linda; Raskin, Salmo; Rosell, Jordi; Rubin, Karol; Seashore, Margretta; Schaaf, Christian P.; Scheuerle, Angela; Schultz, Meredith; Schorry, Elizabeth; Schnur, Rhonda; Siqveland, Elizabeth; Tkachuk, Amanda; Tonsgard, James; Upadhyaya, Meena; Verma, Ishwar C.; Wallace, Stephanie; Williams, Charles; Zackai, Elaine; Zonana, Jonathan; Lazaro, Conxi; Claes, Kathleen; Korf, Bruce; Martin, Yolanda; Legius, Eric

    2015-01-01

    ABSTRACT Neurofibromatosis type 1 (NF1) is one of the most frequent genetic disorders, affecting 1:3,000 worldwide. Identification of genotype–phenotype correlations is challenging because of the wide range clinical variability, the progressive nature of the disorder, and extreme diversity of the mutational spectrum. We report 136 individuals with a distinct phenotype carrying one of five different NF1 missense mutations affecting p.Arg1809. Patients presented with multiple café‐au‐lait macules (CALM) with or without freckling and Lisch nodules, but no externally visible plexiform neurofibromas or clear cutaneous neurofibromas were found. About 25% of the individuals had Noonan‐like features. Pulmonic stenosis and short stature were significantly more prevalent compared with classic cohorts (P < 0.0001). Developmental delays and/or learning disabilities were reported in over 50% of patients. Melanocytes cultured from a CALM in a segmental NF1‐patient showed two different somatic NF1 mutations, p.Arg1809Cys and a multi‐exon deletion, providing genetic evidence that p.Arg1809Cys is a loss‐of‐function mutation in the melanocytes and causes a pigmentary phenotype. Constitutional missense mutations at p.Arg1809 affect 1.23% of unrelated NF1 probands in the UAB cohort, therefore this specific NF1 genotype–phenotype correlation will affect counseling and management of a significant number of patients. PMID:26178382

  15. High Incidence of Noonan Syndrome Features Including Short Stature and Pulmonic Stenosis in Patients carrying NF1 Missense Mutations Affecting p.Arg1809: Genotype-Phenotype Correlation.

    PubMed

    Rojnueangnit, Kitiwan; Xie, Jing; Gomes, Alicia; Sharp, Angela; Callens, Tom; Chen, Yunjia; Liu, Ying; Cochran, Meagan; Abbott, Mary-Alice; Atkin, Joan; Babovic-Vuksanovic, Dusica; Barnett, Christopher P; Crenshaw, Melissa; Bartholomew, Dennis W; Basel, Lina; Bellus, Gary; Ben-Shachar, Shay; Bialer, Martin G; Bick, David; Blumberg, Bruce; Cortes, Fanny; David, Karen L; Destree, Anne; Duat-Rodriguez, Anna; Earl, Dawn; Escobar, Luis; Eswara, Marthanda; Ezquieta, Begona; Frayling, Ian M; Frydman, Moshe; Gardner, Kathy; Gripp, Karen W; Hernández-Chico, Concepcion; Heyrman, Kurt; Ibrahim, Jennifer; Janssens, Sandra; Keena, Beth A; Llano-Rivas, Isabel; Leppig, Kathy; McDonald, Marie; Misra, Vinod K; Mulbury, Jennifer; Narayanan, Vinodh; Orenstein, Naama; Galvin-Parton, Patricia; Pedro, Helio; Pivnick, Eniko K; Powell, Cynthia M; Randolph, Linda; Raskin, Salmo; Rosell, Jordi; Rubin, Karol; Seashore, Margretta; Schaaf, Christian P; Scheuerle, Angela; Schultz, Meredith; Schorry, Elizabeth; Schnur, Rhonda; Siqveland, Elizabeth; Tkachuk, Amanda; Tonsgard, James; Upadhyaya, Meena; Verma, Ishwar C; Wallace, Stephanie; Williams, Charles; Zackai, Elaine; Zonana, Jonathan; Lazaro, Conxi; Claes, Kathleen; Korf, Bruce; Martin, Yolanda; Legius, Eric; Messiaen, Ludwine

    2015-11-01

    Neurofibromatosis type 1 (NF1) is one of the most frequent genetic disorders, affecting 1:3,000 worldwide. Identification of genotype-phenotype correlations is challenging because of the wide range clinical variability, the progressive nature of the disorder, and extreme diversity of the mutational spectrum. We report 136 individuals with a distinct phenotype carrying one of five different NF1 missense mutations affecting p.Arg1809. Patients presented with multiple café-au-lait macules (CALM) with or without freckling and Lisch nodules, but no externally visible plexiform neurofibromas or clear cutaneous neurofibromas were found. About 25% of the individuals had Noonan-like features. Pulmonic stenosis and short stature were significantly more prevalent compared with classic cohorts (P < 0.0001). Developmental delays and/or learning disabilities were reported in over 50% of patients. Melanocytes cultured from a CALM in a segmental NF1-patient showed two different somatic NF1 mutations, p.Arg1809Cys and a multi-exon deletion, providing genetic evidence that p.Arg1809Cys is a loss-of-function mutation in the melanocytes and causes a pigmentary phenotype. Constitutional missense mutations at p.Arg1809 affect 1.23% of unrelated NF1 probands in the UAB cohort, therefore this specific NF1 genotype-phenotype correlation will affect counseling and management of a significant number of patients.

  16. ADVANCED POWER SYSTEMS - ASH BEHAVIOR IN POWER SYSTEMS. INCLUDES THE SEMIANNUAL REPORT FOR THE PERIOD JANUARY 01, 1998 - JUNE 30, 1998.

    SciTech Connect

    1998-09-01

    The overall goal of this initiative is to develop fundamental knowledge of ash behavior in power systems for the purpose of increasing power production efficiency, reducing operation and maintenance costs, and reducing greenhouse gas emissions into the atmosphere. The specific objectives of this initiative focus primarily on ash behavior related to advanced power systems and include the following: Determine the current status of the fundamental ash interactions and deposition formation mechanisms as already reported through previous or ongoing projects at the EERC or in the literature; Determine sintering mechanisms for temperatures and particle compositions that are less well known and remain for the most part undetermined; Identify the relationship between the temperature of critical viscosity (T{sub cv}) as measured in a viscometer and the crystallization occurring in the melt; Perform a literature search on the use of heated-stage microscopy (HSM) for examining in situ ash-sintering phenomena and then validate the use of HSM in the determination of viscosity in spherical ash particles; Ascertain the formation and stability of specific mineral or amorphous phases in deposits typical of advanced power systems; and Evaluate corrosion for alloys being used in supercritical combustion systems.

  17. Feasibility study of advanced technology hov systems. Volume 3. Benefit implications of alternative policies for including hov lanes in route guidance networks. Research report

    SciTech Connect

    Chira-Chavala, T.; Lin, W.H.

    1992-12-01

    This study aims to investigate whether it would be beneficial to include HOV lanes in route guidance networks when high-occupancy-vehicle (HOV) lanes exist on the corridors. This is an important policy issue for a number of reasons. First, HOV lanes are integral parts of many urban corridors in the U.S., and there is no compelling reason at this time to exclude them from route-guidance networks. Second, HOVs share same roadways with single-occupancy-vehicles (SOVs) outside HOV lanes, thus congestion outside HOV lanes also affects HOVs. Therefore, HOVs can conceivably benefit from having route guidance information to guide their journey. Third, evidence suggests that HOV lanes are a good public policy, thus it appears desirable to continue to provide travel-time advantages to HOVs over SOVs even when advanced route guidance technologies become available.

  18. Study of Micro and Nano Scale Features in the Fabrication, Performance, and Degradation of Advanced Engineering Materials

    NASA Astrophysics Data System (ADS)

    Lombardo, Jeffrey John

    Increasingly, modern engineering materials are designed on a micron or nano scale to fulfill a given set of requirements or to enhance the material's performance. In this dissertation several such materials will be studied including catalyst particles for carbon nanotube (CNT) growth by use of atomic force microscopy (AFM) and x-ray photoelectron spectroscopy (XPS), multi walled carbon nanotubes (MWNTs) by reactor scale modeling, hermetic carbon coatings by focused ion beam/ scanning electron microscopy (FIB/SEM) and Fourier transform infrared spectroscopy (FTIR) the latter of which was performed by Andrei Stolov at OFS Specialty Photonics Division (Avon, CT), and Ni/Yttria stabilized zirconia (YSZ) solid oxide fuel cell (SOFC) anodes using X-ray nanotomography (XNT) and X-ray fluorescence (XRF) the second of which was performed by Barry Lai at APS (Argonne National Lab, IL). For each material, a subset of the material properties will be looked at to determine how the selected property affects either the fabrication, performance, or degradation of the material. Following the analysis of these materials, it was found that although the materials are different, the study of micron and nano scale features has many related traits. X-rays and electrons are frequently used to examine nanoscale structures, numerical study can be exploited to expedite measurements and extract additional information from experiments, and the study of these requires knowledge across many scientific fields. As a product of this research, detailed information about all of the materials studied has been contributed to the scientific literature including size dependance information about the oxidation states of nanometer size iron particles, optimal CVD reactor growth conditions for different CNT catalyst particle sizes and number of walls, a technique for rapid measurement of hermetic carbon film thickness, and detailed microstructural detail and sulfur poisoning mapping for Ni/YSZ SOFC anodes.

  19. Interpersonal and Affective Features of Psychopathy in Children and Adolescents: Advancing a Developmental Perspective--Introduction to Special Section

    ERIC Educational Resources Information Center

    Pardini, Dustin A.; Loeber, Rolf

    2007-01-01

    The interpersonal (e.g., manipulative, deceitful) and affective (e.g., callous, unemotional) features associated with adult psychopathy have been identified in children and adolescents. Although early research suggests that these features have clinical utility in identifying a particularly severe and recalcitrant form of antisocial behavior with…

  20. Improved survival of children with advanced neuroblastoma treated by intensified therapy including myeloablative chemotherapy with stem cell transplantation: a retrospective analysis from the Tohoku Neuroblastoma Study Group.

    PubMed

    Imaizumi, M; Watanabe, A; Kikuta, A; Takano, T; Ito, E; Shimizu, T; Tsuchiya, S; Iinuma, K; Konno, T; Ohi, R; Hayashi, Y

    2001-10-01

    In the hospitals of the Tohoku Neuroblastoma Study Group (TNBSG), treatment for children with advanced neuroblastoma (NB) was intensified in the mid-1990's with the introduction of myeloablative therapy (MT) with stem cell transplantation (SCT) including the use of autologous peripheral blood stem cells (PBSC) and bone marrow transplantation (BMT). In this report, we examined whether the intensified therapy improved the outcome of children with advanced NB (age> 12 months) who were diagnosed between 1991 and 1997. Patients were 36 children (23 boys and 13 girls) with an average age of 3.4 years (range; 1 to 14 years). Six of them had stage III disease, and the other 30 had stage IV. They were treated initially with induction chemotherapy, surgery, and post-operative chemoradiotherapy, after which 17 of them continued further chemotherapy and the other 19 received MT/SCT (18 with PBSCT and 1 with BMT). Progression-free survival (PFS) rate at seven years from diagnosis was 43.5% for all patients, 66.7% for stage III patients and 38.2% for stage IV patients. The difference between stage III and IV patients was not significant. Among the 30 patients with stage IV disease, PFS at seven years was significantly higher in the 19 patients who received MT/SCT (55.6%) than in the 11 patients who did not receive it (12.5%). There was no difference in clinical and biological risk factors between these two groups, except for the proportion of patients with favorable response to initial therapy (36% and 80% for patients without and with MT/SCT, respectively). Furthermore, the proportion of patients with N-myc amplification was significantly higher in patients with progressive disease (PD) after MT/SCT than in those in CR after MT/SCT. The results of this retrospective study of children with advanced NB suggest that therapy intensification involving MT/SCT might result in lengthened survival time for patients with stage IV disease, and that post-transplant PD remains a risk for

  1. Pretreatment 18F-FDG PET Textural Features in Locally Advanced Non–Small Cell Lung Cancer: Secondary Analysis of ACRIN 6668/RTOG 0235

    PubMed Central

    Ohri, Nitin; Duan, Fenghai; Snyder, Bradley S.; Wei, Bo; Machtay, Mitchell; Alavi, Abass; Siegel, Barry A.; Johnson, Douglas W.; Bradley, Jeffrey D.; DeNittis, Albert; Werner-Wasik, Maria; El Naqa, Issam

    2016-01-01

    In a secondary analysis of American College of Radiology Imaging Network (ACRIN) 6668/RTOG 0235, high pretreatment metabolic tumor volume (MTV) on 18F-FDG PET was found to be a poor prognostic factor for patients treated with chemoradiotherapy for locally advanced non–small cell lung cancer (NSCLC). Here we utilize the same dataset to explore whether heterogeneity metrics based on PET textural features can provide additional prognostic information. Methods Patients with locally advanced NSCLC underwent 18F-FDG PET prior to treatment. A gradient-based segmentation tool was used to contour each patient’s primary tumor. MTV, maximum SUV, and 43 textural features were extracted for each tumor. To address over-fitting and high collinearity among PET features, the least absolute shrinkage and selection operator (LASSO) method was applied to identify features that were independent predictors of overall survival (OS) after adjusting for MTV. Recursive binary partitioning in a conditional inference framework was utilized to identify optimal thresholds. Kaplan–Meier curves and log-rank testing were used to compare outcomes among patient groups. Results Two hundred one patients met inclusion criteria. The LASSO procedure identified 1 textural feature (SumMean) as an independent predictor of OS. The optimal cutpoint for MTV was 93.3 cm3, and the optimal Sum-Mean cutpoint for tumors above 93.3 cm3 was 0.018. This grouped patients into three categories: low tumor MTV (n = 155; median OS, 22.6 mo), high tumor MTV and high SumMean (n = 23; median OS, 20.0 mo), and high tumor MTV and low SumMean (n = 23; median OS, 6.2 mo; log-rank P < 0.001). Conclusion We have described an appropriate methodology to evaluate the prognostic value of textural PET features in the context of established prognostic factors. We have also identified a promising feature that may have prognostic value in locally advanced NSCLC patients with large tumors who are treated with chemoradiotherapy

  2. Classification of simulated and actual NOAA-6 AVHRR data for hydrologic land-surface feature definition. [Advanced Very High Resolution Radiometer

    NASA Technical Reports Server (NTRS)

    Ormsby, J. P.

    1982-01-01

    An examination of the possibilities of using Landsat data to simulate NOAA-6 Advanced Very High Resolution Radiometer (AVHRR) data on two channels, as well as using actual NOAA-6 imagery, for large-scale hydrological studies is presented. A running average was obtained of 18 consecutive pixels of 1 km resolution taken by the Landsat scanners were scaled up to 8-bit data and investigated for different gray levels. AVHRR data comprising five channels of 10-bit, band-interleaved information covering 10 deg latitude were analyzed and a suitable pixel grid was chosen for comparison with the Landsat data in a supervised classification format, an unsupervised mode, and with ground truth. Landcover delineation was explored by removing snow, water, and cloud features from the cluster analysis, and resulted in less than 10% difference. Low resolution large-scale data was determined useful for characterizing some landcover features if weekly and/or monthly updates are maintained.

  3. Confidence-Based Feature Acquisition

    NASA Technical Reports Server (NTRS)

    Wagstaff, Kiri L.; desJardins, Marie; MacGlashan, James

    2010-01-01

    Confidence-based Feature Acquisition (CFA) is a novel, supervised learning method for acquiring missing feature values when there is missing data at both training (learning) and test (deployment) time. To train a machine learning classifier, data is encoded with a series of input features describing each item. In some applications, the training data may have missing values for some of the features, which can be acquired at a given cost. A relevant JPL example is that of the Mars rover exploration in which the features are obtained from a variety of different instruments, with different power consumption and integration time costs. The challenge is to decide which features will lead to increased classification performance and are therefore worth acquiring (paying the cost). To solve this problem, CFA, which is made up of two algorithms (CFA-train and CFA-predict), has been designed to greedily minimize total acquisition cost (during training and testing) while aiming for a specific accuracy level (specified as a confidence threshold). With this method, it is assumed that there is a nonempty subset of features that are free; that is, every instance in the data set includes these features initially for zero cost. It is also assumed that the feature acquisition (FA) cost associated with each feature is known in advance, and that the FA cost for a given feature is the same for all instances. Finally, CFA requires that the base-level classifiers produce not only a classification, but also a confidence (or posterior probability).

  4. Symposium on ASME codes and recent advances in PVP and valve technology including a survey of operations research methods in engineering

    SciTech Connect

    Fong, J.T.; Hollinger, G.L.; Gowda, B.; Ezekoye, L.I.; Levary, R.R.

    1986-01-01

    This book presents the papers given at a symposium on the design and engineering of reactor pressure vessels, pipes and valves. Topics considered at the symposium included computer-aided fatigue design methods for weldments, the propagation of defects under PWR loading conditions, the fatigue of welded joints in elevated-temperature nuclear components, the design of a bolted flange subjected to severe nuclear system thermal transients, and operations research methods.

  5. Characterisation of "caramel-type" thermal decomposition products of selected monosaccharides including fructose, mannose, galactose, arabinose and ribose by advanced electrospray ionization mass spectrometry methods.

    PubMed

    Golon, Agnieszka; Kuhnert, Nikolai

    2013-07-01

    The chemical analysis of caramel, formed upon heating of carbohydrates, remains a significant challenge due to the complexity of the resulting product mixture. Identification of the products formed upon heating of monosaccharides including fructose, mannose, galactose, arabinose and ribose is essential to understand the composition and properties of carbohydrate-rich processed foods. In this work, we report on the use of combined mass spectrometry techniques, including high performance liquid chromatography and electrospray ionization multi-stage tandem mass spectrometry (ESI-MS(n)). The composition of the obtained caramel was examined by high resolution mass spectrometry along with van Krevelen and Kendrick analysis. We found that caramel is composed of oligomers with up to six carbohydrate units formed through unselective glycosidic bond formation, their dehydrated products by losing up to eight water molecules, hydrated products and disproportionation products. An accurate mass measurement and subsequent fragment ion studies of all caramel samples (around 40 compounds) can thus be identified. Glycosidic bond and ring cleavages of sugar moieties were the major observable fragmentation pathways during this experiment. The innovative analytical strategies for the complex mixture analysis used provide a comprehensive account of the chemical composition of caramel, one of the most popular dietary materials over the world.

  6. An interstitial deletion of 7.1Mb in chromosome band 6p22.3 associated with developmental delay and dysmorphic features including heart defects, short neck, and eye abnormalities.

    PubMed

    Bremer, Anna; Schoumans, Jacqueline; Nordenskjöld, Magnus; Anderlid, Britt-Marie; Giacobini, Maibritt

    2009-01-01

    Seven cases with an interstitial deletion of the short arm of chromosome 6 involving the 6p22 region have previously been reported. The clinical phenotype of these cases includes developmental delay, brain-, heart-, and kidney defects, eye abnormalities, short neck, craniofacial malformations, hypotonia, as well as clinodactyly or syndactyly. Here, we report a patient with a 7.1Mb interstitial deletion of chromosome band 6p22.3, detected by genome-wide screening array CGH. The patient is a 4-year-old girl with developmental delay and dysmorphic features including eye abnormalities, short neck, and a ventricular septum defect. The deleted region at 6p22.3 in our patient overlaps with six out of the seven previously reported cases with a 6p22-24 interstitial deletion. This enabled us to further narrow down the critical region for the 6p22 deletion phenotype to 2.2Mb. Twelve genes are mapped to the overlapping deleted region, among them the gene encoding the ataxin-1 protein, the ATXN1 gene. Mice with homozygous deletions in ATXN1 are phenotypically normal but show cognitive delay. Haploinsufficiency of ATXN1 may therefore contribute to the learning difficulties observed in the patients harboring a 6p22 deletion.

  7. Listening to Include

    ERIC Educational Resources Information Center

    Veck, Wayne

    2009-01-01

    This paper attempts to make important connections between listening and inclusive education and the refusal to listen and exclusion. Two lines of argument are advanced. First, if educators and learners are to include each other within their educational institutions as unique individuals, then they will need to listen attentively to each other.…

  8. Aircrew Training Devices: Utility and Utilization of Advanced Instructional Features (Phase II-Air Training Command, Military Airlift Command, and Strategic Air Command [and] Phase III-Electronic Warfare Trainers).

    ERIC Educational Resources Information Center

    Polzella, Donald J.; Hubbard, David C.

    This document consists of an interim report and a final report which describe the second and third phases of a project designed to determine the utility and utilization of sophisticated hardware and software capabilities known as advanced instructional features (AIFs). Used with an aircrew training device (ATD), AIFs permit a simulator instructor…

  9. Compression station upgrades include advanced noise reduction

    SciTech Connect

    Dunning, V.R.; Sherikar, S.

    1998-10-01

    Since its inception in the mid-`80s, AlintaGas` Dampier to Bunbury natural gas pipeline has been constantly undergoing a series of upgrades to boost capacity and meet other needs. Extending northward about 850 miles from near Perth to the northwest shelf, the 26-inch line was originally served by five compressor stations. In the 1989-91 period, three new compressor stations were added to increase capacity and a ninth station was added in 1997. Instead of using noise-path-treatment mufflers to reduce existing noise, it was decided to use noise-source-treatment technology to prevent noise creation in the first place. In the field, operation of these new noise-source treatment attenuators has been very quiet. If there was any thought earlier of guaranteed noise-level verification, it is not considered a priority now. It`s also anticipated that as AlintaGas proceeds with its pipeline and compressor station upgrade program, similar noise-source treatment equipment will be employed and retrofitted into older stations where the need to reduce noise and potential radiant-heat exposure is indicated.

  10. Comparative Genomic Analysis Identifies Divergent Genomic Features of Pathogenic Enterococcus cecorum Including a Type IC CRISPR-Cas System, a Capsule Locus, an epa-Like Locus, and Putative Host Tissue Binding Proteins

    PubMed Central

    Borst, Luke B.; Suyemoto, M. Mitsu; Scholl, Elizabeth H.; Fuller, Fredrick J.; Barnes, H. John

    2015-01-01

    Enterococcus cecorum (EC) is the dominant enteric commensal of adult chickens and contributes to the gut consortia of many avian and mammalian species. While EC infection is an uncommon zoonosis, like other enterococcal species it can cause life-threating nosocomial infection in people. In contrast to other enterococci which are considered opportunistic pathogens, emerging pathogenic strains of EC cause outbreaks of musculoskeletal disease in broiler chickens. Typical morbidity and mortality is comparable to other important infectious diseases of poultry. In molecular epidemiologic studies, pathogenic EC strains were found to be genetically clonal. These findings suggested acquisition of specific virulence determinants by pathogenic EC. To identify divergent genomic features and acquired virulence determinants in pathogenic EC; comparative genomic analysis was performed on genomes of 3 pathogenic and 3 commensal strains of EC. Pathogenic isolates had smaller genomes with a higher GC content, and they demonstrated large regions of synteny compared to commensal isolates. A molecular phylogenetic analysis demonstrated sequence divergence in pathogenic EC genomes. At a threshold of 98% identity, 414 predicted proteins were identified that were highly conserved in pathogenic EC but not in commensal EC. Among these, divergent CRISPR-cas defense loci were observed. In commensal EC, the type IIA arrangement typical for enterococci was present; however, pathogenic EC had a type IC locus, which is novel in enterococci but commonly observed in streptococci. Potential mediators of virulence identified in this analysis included a polysaccharide capsular locus similar to that recently described for E. faecium, an epa-like locus, and cell wall associated proteins which may bind host extracellular matrix. This analysis identified specific genomic regions, coding sequences, and predicted proteins which may be related to the divergent evolution and increased virulence of emerging

  11. Comparative genomic analysis identifies divergent genomic features of pathogenic Enterococcus cecorum including a type IC CRISPR-Cas system, a capsule locus, an epa-like locus, and putative host tissue binding proteins.

    PubMed

    Borst, Luke B; Suyemoto, M Mitsu; Scholl, Elizabeth H; Fuller, Fredrick J; Barnes, H John

    2015-01-01

    Enterococcus cecorum (EC) is the dominant enteric commensal of adult chickens and contributes to the gut consortia of many avian and mammalian species. While EC infection is an uncommon zoonosis, like other enterococcal species it can cause life-threating nosocomial infection in people. In contrast to other enterococci which are considered opportunistic pathogens, emerging pathogenic strains of EC cause outbreaks of musculoskeletal disease in broiler chickens. Typical morbidity and mortality is comparable to other important infectious diseases of poultry. In molecular epidemiologic studies, pathogenic EC strains were found to be genetically clonal. These findings suggested acquisition of specific virulence determinants by pathogenic EC. To identify divergent genomic features and acquired virulence determinants in pathogenic EC; comparative genomic analysis was performed on genomes of 3 pathogenic and 3 commensal strains of EC. Pathogenic isolates had smaller genomes with a higher GC content, and they demonstrated large regions of synteny compared to commensal isolates. A molecular phylogenetic analysis demonstrated sequence divergence in pathogenic EC genomes. At a threshold of 98% identity, 414 predicted proteins were identified that were highly conserved in pathogenic EC but not in commensal EC. Among these, divergent CRISPR-cas defense loci were observed. In commensal EC, the type IIA arrangement typical for enterococci was present; however, pathogenic EC had a type IC locus, which is novel in enterococci but commonly observed in streptococci. Potential mediators of virulence identified in this analysis included a polysaccharide capsular locus similar to that recently described for E. faecium, an epa-like locus, and cell wall associated proteins which may bind host extracellular matrix. This analysis identified specific genomic regions, coding sequences, and predicted proteins which may be related to the divergent evolution and increased virulence of emerging

  12. Advanced Microsensors

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This video looks at a spinoff application of the technology from advanced microsensors -- those that monitor and determine conditions of spacecraft like the Space Shuttle. The application featured is concerned with the monitoring of the health of premature babies.

  13. Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer

    PubMed Central

    Eyking, Annette; Ey, Birgit; Rünzi, Michael; Roig, Andres I.; Reis, Henning; Schmid, Kurt W.; Gerken, Guido; Podolsky, Daniel K.; Cario, Elke

    2012-01-01

    Background & Aims The Toll-like receptor (TLR) 4 mediates homeostasis of the intestinal epithelial cell (IEC) barrier. We investigated the effects of TLR4-D299G on IEC functions. Methods We engineered IECs (Caco-2) to stably overexpress hemagglutinin-tagged wild-type TLR4, TLR4-D299G, or TLR4-T399I. We performed gene expression profiling using DNA microarray analysis. Findings were confirmed by real-time, quantitative, reverse-transcriptase polymerase chain reaction, immunoblot, enzyme-linked immunosorbent assay, confocal immunofluorescence, and functional analyses. Tumorigenicity was tested using the CD1 nu/nu mice xenograft model. Human colon cancer specimens (N = 214) were genotyped and assessed for disease stage. Results Caco-2 cells that expressed TLR4-D299G underwent the epithelial-mesenchymal transition and morphologic changes associated with tumor progression, whereas cells that expressed wild-type TLR4 or TLR4-T399I did not. Caco-2 cells that expressed TLR4-D299G had significant increases in expression levels of genes and proteins associated with inflammation and/or tumorigenesis compared with cells that expressed other forms of TLR4. The invasive activity of TLR4-D299G Caco-2 cells required Wnt-dependent activation of STAT3. In mice, intestinal xenograft tumors grew from Caco-2 cells that expressed TLR4-D299G, but not cells that expressed other forms of TLR4; tumor growth was blocked by a specific inhibitor of STAT3. Human colon adenocarcinomas from patients with TLR4-D299G were more frequently of an advanced stage (International Union Against Cancer [UICC] ≥III, 70% vs 46%; P = .0142) with metastasis (UICC IV, 42% vs 19%; P = .0065) than those with wild-type TLR4. Expression of STAT3 messenger RNA was higher among colonic adenocarcinomas with TLR4-D299G than those with wild-type TLR4. Conclusions TLR4-D299G induces features of neoplastic progression in intestinal epithelial Caco-2 cells and associates with aggressive colon cancer in humans, implying a

  14. Structural features of a bituminous coal and their changes during low-temperature oxidation and loss of volatiles investigated by advanced solid-state NMR spectroscopy

    USGS Publications Warehouse

    Mao, J.-D.; Schimmelmann, A.; Mastalerz, Maria; Hatcher, P.G.; Li, Y.

    2010-01-01

    Quantitative and advanced 13C solid-state NMR techniques were employed to investigate (i) the chemical structure of a high volatile bituminous coal, as well as (ii) chemical structural changes of this coal after evacuation of adsorbed gases, (iii) during oxidative air exposure at room temperature, and (iv) after oxidative heating in air at 75 ??C. The solid-state NMR techniques employed in this study included quantitative direct polarization/magic angle spinning (DP/MAS) at a high spinning speed of 14 kHz, cross polarization/total sideband suppression (CP/TOSS), dipolar dephasing, CH, CH2, and CHn selection, 13C chemical shift anisotropy (CSA) filtering, two-dimensional (2D) 1H-13C heteronuclear correlation NMR (HETCOR), and 2D HETCOR with 1H spin diffusion. With spectral editing techniques, we identified methyl CCH 3, rigid and mobile methylene CCH2C, methine CCH, quaternary Cq, aromatic CH, aromatic carbons bonded to alkyls, small-sized condensed aromatic moieties, and aromatic C-O groups. With direct polarization combined with spectral-editing techniques, we quantified 11 different types of functional groups. 1H-13C 2D HETCOR NMR experiments indicated spatial proximity of aromatic and alkyl moieties in cross-linked structures. The proton spin diffusion experiments indicated that the magnetization was not equilibrated at a 1H spin diffusion time of 5 ms. Therefore, the heterogeneity in spatial distribution of different functional groups should be above 2 nm. Recoupled C-H long-range dipolar dephasing showed that the fraction of large charcoal-like clusters of polycondensed aromatic rings was relatively small. The exposure of this coal to atmospheric oxygen at room temperature for 6 months did not result in obvious chemical structural changes of the coal, whereas heating at 75 ??C in air for 10 days led to oxidation of coal and generated some COO groups. Evacuation removed most volatiles and caused a significant reduction in aliphatic signals in its DP

  15. Web Search Engines: Search Syntax and Features.

    ERIC Educational Resources Information Center

    Ojala, Marydee

    2002-01-01

    Presents a chart that explains the search syntax, features, and commands used by the 12 most widely used general Web search engines. Discusses Web standardization, expanded types of content searched, size of databases, and search engines that include both simple and advanced versions. (LRW)

  16. Characterizing Mafic, Clay, and Carbonate Components found in MRO/CRISM Images in Libya Montes, Mars, using Advances in Automated Gaussian Modeling of Spectral Features

    NASA Astrophysics Data System (ADS)

    Makarewicz, H. D.; Parente, M.; Perry, K. A.; McKeown, N. K.; Bishop, J. L.

    2009-12-01

    Aqueous processes have been inferred at the Libya Montes rim/terrace complex of the southern Isidis Basin due to the dense concentration of valley networks [1]. Coordinated CRISM-HiRISE investigations of this region characterized discrete units of ancient phyllosilicate deposits covered by an olivine-rich material and a pyroxene caprock [2]. CRISM mapping data show minor phyllosilicate abundances widespread throughout the Southern Highlands [3], which are dominated by low-Ca pyroxene bearing material [4,5]. The carbonate magnesite has also been located throughout this area [6] and at Libya Montes [7]. Our current study involves detailed characterization of the minerals present at Libya Montes through implementation of improved automated Gaussian modeling methods. We have developed an automated procedure for modeling spectral features using Gaussians that has been successfully applied to laboratory studies and hyperspectral analyses of Mars [8,9,10,11]. Several studies are being conducted to improve and validate these models. These include a comparison of initialization methods, continuum methods, optimization algorithms, and modeled functions. The modeled functions compared include Gaussians, saturated Gaussians, and Lorentzians. This algorithm and the modeling studies are currently being applied towards analyses of CRISM hyperspectral images of Libya Montes and laboratory spectra of mineral mixtures. Specifically, olivine, pyroxene, phyllosilicate, and carbonate deposits are being modeled and classified by composition in CRISM images. References [1]Crumpler, L. S., and K. L. Tanaka (2003) J. Geophys. Res., 108, DOI: 8010.1029/2002JE002040. [2]Bishop, J. L., et al. (2007) 7th Int'l Mars Conf. [3]Mustard, J. F., et al. (2008) Nature, 454, 07305. [4]Bibring, J.-P., et al. (2005) Science, 307,1576. [5]Mustard, J. F., et al.(2005) Science, 307, 1594. [6]Ehlmann, B. L., et al. (2008) Science, 322, 1828. [7]Perry, K., et al. (2009) AGU Fall Mtng. [8]Makarewicz, H. D., et

  17. Shallow seafloor glacial features reveal ice streaming and re-advance of the last British Ice Sheet, offshore eastern Scotland and north-eastern England, UK

    NASA Astrophysics Data System (ADS)

    Stewart, H. A.; Bradwell, T.

    2013-12-01

    Multibeam echosounder datasets have been combined with high-resolution topographic digital surface models (NEXTMap), 2D seismic reflection profiles and shallow cores to reveal strong evidence for onshore-offshore palaeo-ice streaming in eastern Scotland and north-eastern England, UK. The study area includes the catchments of the previously proposed, but only partly mapped, Strathmore, Forth-Tay, and Tweed palaeo-ice streams. Long suspected to terminate offshore, the full flow path and dimensions of this palaeo-ice stream system can now be reconstructed with some certainty using these new data. The ice sheet glacial landsystem is extremely well preserved on the seabed with four main types of subglacial and ice marginal morphology present: 1) highly elongate flow-parallel ridges and grooves strongly suggestive of ice streaming; 2) shorter-elongation flow aligned drumlins and crag and tails indicative of fast-flowing and persistent ice-sheet flow configurations; 3) large arcuate moraine ridges marking frontal stillstands or readvances of the ice sheet margin; and 4) tunnel valleys and deeply incised meltwater channels probably associated with retreat phases of the British Ice Sheet (BIS) following Last Glacial Maximum. The mapped bedforms indicate that fast-flowing corridors (palaeo-ice streams) existed within the last BIS emanating from the central belt of Scotland and northeast England. This new geomorphological evidence shows that these ice streams extended at least 60km offshore and probably accelerated across the transition from bedrock-dominated onshore terrain to till- dominated North Sea Basin. Of particular note is the observation that the Forth-Tay ice stream diverged, forming two glaciologically separate streams running parallel to the present-day coastline. Evidence shows that the southerly arm of this palaeo-ice stream overprinted the Tweed palaeo-ice stream which is contrary to the previously proposed trajectory. Spatial and morphological relationships

  18. An Overview of Electronic Passport Security Features

    NASA Astrophysics Data System (ADS)

    Říha, Zdeněk

    Electronic passports include contactless chip which stores personal data of the passport holder, information about the passport and the issuing institution. In its simplest form an electronic passport contains just a collection of read-only files, more advanced variants can include sophisticated cryptographic mechanisms protecting security of the document and / or privacy of the passport holder. This paper describes security features of electronic passports and discusses their efficiency.

  19. Advancing representation of hydrologic processes in the Soil and Water Assessment Tool (SWAT) through integration of the TOPographic MODEL (TOPMODEL) features

    NASA Astrophysics Data System (ADS)

    Chen, Ji; Wu, Yiping

    2012-02-01

    SummaryThis paper presents a study of the integration of the Soil and Water Assessment Tool (SWAT) model and the TOPographic MODEL (TOPMODEL) features for enhancing the physical representation of hydrologic processes. In SWAT, four hydrologic processes, which are surface runoff, baseflow, groundwater re-evaporation and deep aquifer percolation, are modeled by using a group of empirical equations. The empirical equations usually constrain the simulation capability of relevant processes. To replace these equations and to model the influences of topography and water table variation on streamflow generation, the TOPMODEL features are integrated into SWAT, and a new model, the so-called SWAT-TOP, is developed. In the new model, the process of deep aquifer percolation is removed, the concept of groundwater re-evaporation is refined, and the processes of surface runoff and baseflow are remodeled. Consequently, three parameters in SWAT are discarded, and two new parameters to reflect the TOPMODEL features are introduced. SWAT-TOP and SWAT are applied to the East River basin in South China, and the results reveal that, compared with SWAT, the new model can provide a more reasonable simulation of the hydrologic processes of surface runoff, groundwater re-evaporation, and baseflow. This study evidences that an established hydrologic model can be further improved by integrating the features of another model, which is a possible way to enhance our understanding of the workings of catchments.

  20. Advancing representation of hydrologic processes in the Soil and Water Assessment Tool (SWAT) through integration of the TOPographic MODEL (TOPMODEL) features

    USGS Publications Warehouse

    Chen, J.; Wu, Y.

    2012-01-01

    This paper presents a study of the integration of the Soil and Water Assessment Tool (SWAT) model and the TOPographic MODEL (TOPMODEL) features for enhancing the physical representation of hydrologic processes. In SWAT, four hydrologic processes, which are surface runoff, baseflow, groundwater re-evaporation and deep aquifer percolation, are modeled by using a group of empirical equations. The empirical equations usually constrain the simulation capability of relevant processes. To replace these equations and to model the influences of topography and water table variation on streamflow generation, the TOPMODEL features are integrated into SWAT, and a new model, the so-called SWAT-TOP, is developed. In the new model, the process of deep aquifer percolation is removed, the concept of groundwater re-evaporation is refined, and the processes of surface runoff and baseflow are remodeled. Consequently, three parameters in SWAT are discarded, and two new parameters to reflect the TOPMODEL features are introduced. SWAT-TOP and SWAT are applied to the East River basin in South China, and the results reveal that, compared with SWAT, the new model can provide a more reasonable simulation of the hydrologic processes of surface runoff, groundwater re-evaporation, and baseflow. This study evidences that an established hydrologic model can be further improved by integrating the features of another model, which is a possible way to enhance our understanding of the workings of catchments.

  1. Advances in optics for biotechnology, medicine and surgery.

    PubMed

    Fitzmaurice, Maryann; Pogue, Brian W; Tearney, Guillermo J; Tunnell, James W; Yang, Changhuei

    2014-02-01

    The guest editors introduce a Biomedical Optics Express feature issue that includes contributions from participants at the 2013 conference on Advances in Optics for Biotechnology, Medicine and Surgery XIII.

  2. Advances in optics for biotechnology, medicine and surgery.

    PubMed

    Fitzmaurice, Maryann; Pogue, Brian W; Tearney, Guillermo J; Tunnell, James W; Yang, Changhuei

    2014-02-01

    The guest editors introduce a Biomedical Optics Express feature issue that includes contributions from participants at the 2013 conference on Advances in Optics for Biotechnology, Medicine and Surgery XIII. PMID:24575348

  3. Advances in optics for biotechnology, medicine and surgery

    PubMed Central

    Fitzmaurice, Maryann; Pogue, Brian W.; Tearney, Guillermo J.; Tunnell, James W.; Yang, Changhuei

    2014-01-01

    The guest editors introduce a Biomedical Optics Express feature issue that includes contributions from participants at the 2013 conference on Advances in Optics for Biotechnology, Medicine and Surgery XIII. PMID:24575348

  4. Research Advances

    ERIC Educational Resources Information Center

    King, Angela G.

    2004-01-01

    Research advances, a new feature in Journal of Chemical Engineering that brings information about innovations in current areas of research to high school and college science faculty with an intent to provide educators with timely descriptions of latest progress in research that can be integrated into existing courses to update course content and…

  5. Isotope separation and advanced manufacturing technology

    NASA Astrophysics Data System (ADS)

    Carpenter, J.; Kan, T.

    This is the fourth issue of a semiannual report for the Isotope Separation and Advanced Materials Manufacturing (ISAM) Technology Program at Lawrence Livermore National Laboratory. Primary objectives include: (1) the Uranium Atomic Vapor Laser Isotope Separation (UAVLIS) process, which is being developed and prepared for deployment as an advanced uranium enrichment capability; (2) Advanced manufacturing technologies, which include industrial laser and E-beam material processing and new manufacturing technologies for uranium, plutonium, and other strategically important materials in support of DOE and other national applications. This report features progress in the ISAM Program from October 1993 through March 1994.

  6. 34 CFR 303.15 - Include; including.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Include; including. 303.15 Section 303.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND TODDLERS...

  7. ORNL Lightweighting Research Featured on MotorWeek

    ScienceCinema

    None

    2016-07-12

    PBS MotorWeek, television's longest running automotive series, featured ORNL lightweighting research for vehicle applications in an episode that aired in early April 2014. The crew captured footage of research including development of new metal alloys, additive manufacturing, carbon fiber production, advanced batteries, power electronics components, and neutron imaging applications for materials evaluation.

  8. ORNL Lightweighting Research Featured on MotorWeek

    SciTech Connect

    2014-04-15

    PBS MotorWeek, television's longest running automotive series, featured ORNL lightweighting research for vehicle applications in an episode that aired in early April 2014. The crew captured footage of research including development of new metal alloys, additive manufacturing, carbon fiber production, advanced batteries, power electronics components, and neutron imaging applications for materials evaluation.

  9. Advanced manned earth-to-orbit vehicle

    NASA Astrophysics Data System (ADS)

    Eldred, Charles H.

    1986-10-01

    Advanced manned launch vehicle concepts which are designed to meet the space transportation architecture and mission needs for the early 21st century are described. Concepts are described which are based both on modest (evolutionary) and revolutionary advancements in performance technologies but with emphasis on defining operations cost. Design options feature fully reusable, vertical-takeoff, horizontal-landing, rocket-powered concepts and include a variety of possible staging arrangements depending on the desired mission emphasis and the available technologies.

  10. Sedimentation dynamics about salt features

    SciTech Connect

    Lowrie, A.; Blake, D.W.

    1985-02-01

    Detailed side-scan sonar and gridded bathymetric surveys on continental margins reveal the existence of numerous submarine canyons. Recently published compilations of current velocities in submarine canyons indicate that alternating and undirectionaly flows often exceed 20-30 cm/sec with peak velocities ranging from 70 to 100 cm/sec. Current meters attached to the ocean floor have been lost at current velocities of 190 cm/sec. Such velocities are ample to transport sand-size sediments. The results of DSDP Leg 96 show the existence of massive sands and gravels on the Louisiana slope, deposited during the last glacial advance. Thus, present physical oceanographic data may be an analog to conditions during glacially induced lowered sea levels. Salt ridges and domes underlie much of the Louisiana slope, determining morphology. Submarine canyons lace the slope. Given a prograding shelf, the net sediment transport routes will be down the submarine canyons. Sediment deposition patterns around the salt ridges and domes include parallel-bedded foredrifts on the upslope side, lee drifts on the downslope side, and moats along the lateral flanks of the salt features. Major differences exist between the sedimentation patterns around a ridge and a dome. The size and shape of the flow pattern will determine whether there can be a flow over the salt feature with a resulting turbulent wave that may influence sedimentation. Sedimentation patterns about salt features on the present slope should be applicable to similar paleoenvironments.

  11. General features

    SciTech Connect

    Wallace, R.E.

    1990-01-01

    The San Andreas fault system, a complex of faults that display predominantly large-scale strike slip, is part of an even more complex system of faults, isolated segments of the East Pacific Rise, and scraps of plates lying east of the East Pacific Rise that collectively separate the North American plate from the Pacific plate. This chapter briefly describes the San Andreas fault system, its setting along the Pacific Ocean margin of North America, its extent, and the patterns of faulting. Only selected characteristics are described, and many features are left for depictions on maps and figures.

  12. New features in MEDM.

    SciTech Connect

    Evans, K., Jr.

    1999-04-13

    MEDM, which is derived from Motif Editor and Display Manager, is the primary graphical interface to the EPICS control system. This paper describes new features that have been added to MEDM in the last two years. These features include new editing capabilities, a PV Info dialog box, a means of specifying limits and precision, a new implementation of the Cartesian Plot, new features for several objects, new capability for the Related Display, help, a user-configurable Execute Menu, reconfigured start-up options, and availability for Windows 95/98/NT. Over one hundred bugs have been fixed, and the program is quite stable and in extensive use.

  13. Feature Characterization Library

    2006-08-03

    FCLib is a data analysis toolkit constructed to meet the needs of data discovery in large-scale, spatio-temporal data such as finite element simulation data. FCLib is a C library toolkit of building blocks that can be assembled into complex analyses. Important features of FCLib include the following: (1) Support of feature-based analysis, (2) minimization of low-oevel processing, (3) ease of use, and (4) applicable to the wide variety of science domains.

  14. Pump apparatus including deconsolidator

    SciTech Connect

    Sonwane, Chandrashekhar; Saunders, Timothy; Fitzsimmons, Mark Andrew

    2014-10-07

    A pump apparatus includes a particulate pump that defines a passage that extends from an inlet to an outlet. A duct is in flow communication with the outlet. The duct includes a deconsolidator configured to fragment particle agglomerates received from the passage.

  15. Feature-based tolerancing for intelligent inspection process definition

    SciTech Connect

    Brown, C.W.

    1993-07-01

    This paper describes a feature-based tolerancing capability that complements a geometric solid model with an explicit representation of conventional and geometric tolerances. This capability is focused on supporting an intelligent inspection process definition system. The feature-based tolerance model`s benefits include advancing complete product definition initiatives (e.g., STEP -- Standard for Exchange of Product model dam), suppling computer-integrated manufacturing applications (e.g., generative process planning and automated part programming) with product definition information, and assisting in the solution of measurement performance issues. A feature-based tolerance information model was developed based upon the notion of a feature`s toleranceable aspects and describes an object-oriented scheme for representing and relating tolerance features, tolerances, and datum reference frames. For easy incorporation, the tolerance feature entities are interconnected with STEP solid model entities. This schema will explicitly represent the tolerance specification for mechanical products, support advanced dimensional measurement applications, and assist in tolerance-related methods divergence issues.

  16. Feature detection techniques for preprocessing proteomic data.

    PubMed

    Sellers, Kimberly F; Miecznikowski, Jeffrey C

    2010-01-01

    Numerous gel-based and nongel-based technologies are used to detect protein changes potentially associated with disease. The raw data, however, are abundant with technical and structural complexities, making statistical analysis a difficult task. Low-level analysis issues (including normalization, background correction, gel and/or spectral alignment, feature detection, and image registration) are substantial problems that need to be addressed, because any large-level data analyses are contingent on appropriate and statistically sound low-level procedures. Feature detection approaches are particularly interesting due to the increased computational speed associated with subsequent calculations. Such summary data corresponding to image features provide a significant reduction in overall data size and structure while retaining key information. In this paper, we focus on recent advances in feature detection as a tool for preprocessing proteomic data. This work highlights existing and newly developed feature detection algorithms for proteomic datasets, particularly relating to time-of-flight mass spectrometry, and two-dimensional gel electrophoresis. Note, however, that the associated data structures (i.e., spectral data, and images containing spots) used as input for these methods are obtained via all gel-based and nongel-based methods discussed in this manuscript, and thus the discussed methods are likewise applicable.

  17. Vertical Feature Mask Feature Classification Flag Extraction

    Atmospheric Science Data Center

    2013-03-28

      Vertical Feature Mask Feature Classification Flag Extraction This routine demonstrates extraction of the ... in a CALIPSO Lidar Level 2 Vertical Feature Mask feature classification flag value. It is written in Interactive Data Language (IDL) ...

  18. Optical modulator including grapene

    DOEpatents

    Liu, Ming; Yin, Xiaobo; Zhang, Xiang

    2016-06-07

    The present invention provides for a one or more layer graphene optical modulator. In a first exemplary embodiment the optical modulator includes an optical waveguide, a nanoscale oxide spacer adjacent to a working region of the waveguide, and a monolayer graphene sheet adjacent to the spacer. In a second exemplary embodiment, the optical modulator includes at least one pair of active media, where the pair includes an oxide spacer, a first monolayer graphene sheet adjacent to a first side of the spacer, and a second monolayer graphene sheet adjacent to a second side of the spacer, and at least one optical waveguide adjacent to the pair.

  19. Citing geospatial feature inventories with XML manifests

    NASA Astrophysics Data System (ADS)

    Bose, R.; McGarva, G.

    2006-12-01

    Today published scientific papers include a growing number of citations for online information sources that either complement or replace printed journals and books. We anticipate this same trend for cartographic citations used in the geosciences, following advances in web mapping and geographic feature-based services. Instead of using traditional libraries to resolve citations for print material, the geospatial citation life cycle will include requesting inventories of objects or geographic features from distributed geospatial data repositories. Using a case study from the UK Ordnance Survey MasterMap database, which is illustrative of geographic object-based products in general, we propose citing inventories of geographic objects using XML feature manifests. These manifests: (1) serve as a portable listing of sets of versioned features; (2) could be used as citations within the identification portion of an international geospatial metadata standard; (3) could be incorporated into geospatial data transfer formats such as GML; but (4) can be resolved only with comprehensive, curated repositories of current and historic data. This work has implications for any researcher who foresees the need to make or resolve references to online geospatial databases.

  20. Time Varying Feature Data

    NASA Astrophysics Data System (ADS)

    Echterhoff, J.; Simonis, I.; Atkinson, R.

    2012-04-01

    The infrastructure to gather, store and access information about our environment is improving and growing rapidly. The increasing amount of information allows us to get a better understanding of the current state of our environment, historical processes and to simulate and predict the future state of the environment. Finer grained spatial and temporal data and more reliable communications make it easier to model dynamic states and ephemeral features. The exchange of information within and across geospatial domains is facilitated through the use of harmonized information models. The Observations & Measurements (O&M) developed through OGC and standardised by ISO is an example of such a cross-domain information model. It is used in many domains, including meteorology, hydrology as well as the emergency management. O&M enables harmonized representation of common metadata that belong to the act of determining the state of a feature property, whether by sensors, simulations or humans. In addition to the resulting feature property value, information such as the result quality but especially the time that the result applies to the feature property can be represented. Temporal metadata is critical to modelling past and future states of a feature. The features, and the semantics of each property, are defined in domain specific Application Schema using the General Feature Model (GFM) from ISO 19109 and usually encoded following ISO 19136. However, at the moment these standards provide only limited support for the representation and handling of time varying feature data. Features like rivers, wildfires or gas plumes have a defined state - for example geographic extent - at any given point in time. To keep track of changes, a more complex model for example using time-series coverages is required. Furthermore, the representation and management of feature property value changes via the service interfaces defined by OGC and ISO - namely: WFS and WCS - would be rather complex

  1. Integrated Education. Feature Issue.

    ERIC Educational Resources Information Center

    York, Jennifer, Ed.; Vandercook, Terri, Ed.

    1988-01-01

    This "feature issue" provides various perspectives on a number of integrated education topics, including successful integration practices and strategies, the changing roles of teachers, the appropriate role of research, the history and future of integrated education, and the realization of dreams of life in the mainstream for children with severe…

  2. Feature++: Automatic Feature Construction for Clinical Data Analysis.

    PubMed

    Sun, Wen; Hao, Bibo; Yu, Yiqin; Li, Jing; Hu, Gang; Xie, Guotong

    2016-01-01

    With the rapid growth of clinical data and knowledge, feature construction for clinical analysis becomes increasingly important and challenging. Given a clinical dataset with up to hundreds or thousands of columns, the traditional manual feature construction process is usually too labour intensive to generate a full spectrum of features with potential values. As a result, advanced large-scale data analysis technologies, such as feature selection for predictive modelling, cannot be fully utilized for clinical data analysis. In this paper, we propose an automatic feature construction framework for clinical data analysis, namely, Feature++. It leverages available public knowledge to understand the semantics of the clinical data, and is able to integrate external data sources to automatically construct new features based on predefined rules and clinical knowledge. We demonstrate the effectiveness of Feature++ in a typical predictive modelling use case with a public clinical dataset, and the results suggest that the proposed approach is able to fulfil typical feature construction tasks with minimal dataset specific configurations, so that more accurate models can be obtained from various clinical datasets in a more efficient way. PMID:27577443

  3. Structural features of algebraic quantum notations

    NASA Astrophysics Data System (ADS)

    Gire, Elizabeth; Price, Edward

    2015-12-01

    [This paper is part of the Focused Collection on Upper Division Physics Courses.] The formalism of quantum mechanics includes a rich collection of representations for describing quantum systems, including functions, graphs, matrices, histograms of probabilities, and Dirac notation. The varied features of these representations affect how computations are performed. For example, identifying probabilities of measurement outcomes for a state described in Dirac notation may involve identifying expansion coefficients by inspection, but if the state is described as a function, identifying those expansion coefficients often involves performing integrals. In this study, we focus on three notational systems: Dirac notation, algebraic wave-function notation, and matrix notation. These quantum notations must include information about basis states and their associated complex probability amplitudes. In this theory paper, we identify four structural features of quantum notations, which we term individuation, degree of externalization, compactness, and symbolic support for computational rules. We illustrate how student reasoning interacts with these structural features with episodes from interviews with advanced undergraduate physics majors reasoning about a superposition state of an infinite square well system. We find evidence of the students coordinating different notations through the use of Dirac notation, using an expression in Dirac notation to guide their work in another notation. These uses are supported by the high degree of individuation, compactness, and symbolic support for computation and the moderate degree of externalization provided by Dirac notation.

  4. Design of the advanced regional aircraft, the DART-75

    NASA Technical Reports Server (NTRS)

    Elliott, Steve; Gislason, Jason; Huffstetler, Mark; Mann, Jon; Withers, Ashley; Zimmerman, Mark

    1992-01-01

    This design analysis is intended to show the capabilities of the DART-75, a 75 passenger medium-range regional transport. Included are the detailed descriptions of the structures, performance, stability and control, weight and balance, and engine design. The design should allow for the DART to become the premier regional aircraft of the future due to some advanced features like the canard, semi-composite construction, and advanced engines.

  5. Advance directives: the New Zealand context.

    PubMed

    Wareham, Pauline; McCallin, Antoinette; Diesfeld, Kate

    2005-07-01

    Advance directives convey consumers' wishes about accepting or refusing future treatment if they become incompetent. They are designed to communicate a competent consumer's perspective regarding the preferred treatment, should the consumer later become incompetent. There are associated ethical issues for health practitioners and this article considers the features that are relevant to nurses. In New Zealand, consumers have a legal right to use an advance directive that is not limited to life-prolonging care and includes general health procedures. Concerns may arise regarding a consumer's competence and the document's validity. Nurses need to understand their legal and professional obligations to comply with an advance directive. What role does a nurse play and what questions arise for a nurse when advance directives are discussed with consumers? This article considers the cultural dimensions, legal boundaries, consumers' and providers' perspectives, and the medical and nursing positions in New Zealand. PMID:16045243

  6. Advanced computing

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Advanced concepts in hardware, software and algorithms are being pursued for application in next generation space computers and for ground based analysis of space data. The research program focuses on massively parallel computation and neural networks, as well as optical processing and optical networking which are discussed under photonics. Also included are theoretical programs in neural and nonlinear science, and device development for magnetic and ferroelectric memories.

  7. Advanced night vision goggles

    NASA Astrophysics Data System (ADS)

    Thacker, Clinton

    2003-02-01

    The Advanced Night Vision Goggle (ANVG) program is developing integrated wide field of view (WFOV) helmet-mounted image intensifier night vision goggle systems. ANVG will provide a FOV of approximately 40° (vertical) × 100° (horizontal) and an integrated heads-up display for overlay of flight symbology and/or FLIR imagery. The added FLIR complements the I2 imagery in out of the window or ground applications. ANVG will significantly improve safety, situational awareness, and mission capabilities in differing environments. ANVG achieves the ultra wide FOV using four image intensifier tubes in a head-mounted configuration. Additional features include a miniature flat panel display and a lightweight uncooled FLIR. The integrated design will demonstrate the capability of helmet-mounted I2 and FLIR image fusion. Fusion will be accomplished optically and will offer significant opportunities for ground applications. This paper summarizes the basic technologies, lessons learned, and program status.

  8. Advanced subsystems development

    NASA Technical Reports Server (NTRS)

    Livingston, F. R.

    1978-01-01

    The concept design for a small (less than 10 MWe) solar thermal electric generating plant was completed using projected 1985 technology. The systems requirements were defined and specified. The components, including an engineering prototype for one 15 kWe module of the generating plant, were conceptually designed. Significant features of the small solar thermal power plant were identified as the following: (1) 15 kWe Stirling-cycle engine/alternator with constant power output; (2) 10 meter point-focusing paraboloidal concentrator with cantilevered cellular glass reflecting panels; (3) primary heat pipe with 800 C output solar cavity receiver; (4) secondary heat pipe with molten salt thermal energy storage unit; (5) electric energy transport system; and (6) advanced battery energy storage capability.

  9. Unique features in the ARIES glovebox line

    SciTech Connect

    Martinez, H.E.; Brown, W.G.; Flamm, B.; James, C.A.; Laskie, R.; Nelson, T.O.; Wedman, D.E.

    1998-12-31

    A series of unique features have been incorporated into the Advanced Recovery and Integrated Extraction System (ARIES) at the Los Alamos National Laboratory, TA-55 Plutonium Facility. The features enhance the material handling in the process of the dismantlement of nuclear weapon primaries in the glovebox line. Incorporated into these features are the various plutonium process module`s different ventilation zone requirements that the material handling systems must meet. These features include a conveyor system that consists of a remotely controlled cart that transverses the length of the conveyor glovebox, can be operated from a remote location and can deliver process components to the entrance of any selected module glovebox. Within the modules there exists linear motion material handling systems with lifting hoist, which are controlled via an Allen Bradley control panel or local control panels. To remove the packaged products from the hot process line, the package is processed through an air lock/electrolytic decontamination process that removes the radioactive contamination from the outside of the package container and allows the package to be removed from the process line.

  10. Cryovolcanic Features on Titan

    NASA Astrophysics Data System (ADS)

    Lopes, R. M. C.; Stofan, E. R.; Kirk, R. L.; Mitchell, K. L.; LeGall, A.; Barnes, J. W.; Hayes, A.; Kargel, J.; Radebaugh, J.; Janssen, M. A.; Neish, C. D.; Wood, C.; Wall, S. D.; Lunine, J. I.; Malaska, M. J.

    2013-09-01

    We present evidence to support the cryovolcanic origin of some features, which includes the deepest pit known on Titan (Sotra Patera) and some of the highest mountains (Doom and Erebor Montes). We interpret this region to be a cryovolcanic complex of multiple cones, craters, and flows. Elsewhere, a circular feature, approximately 100 km across, is morphologically similar to a laccolith, showing a cross pattern interpreted to be extensional fractures. However, we find that some other previously supposed cryovolcanic features were likely formed by other processes. We discuss implications for eruption style and composition of cryovolcanism on Titan. Our analysis shows the great value of combining data sets when interpreting Titan's geology and in particular stresses the value of topographic data.

  11. Three featured plenary sessions

    NASA Astrophysics Data System (ADS)

    2012-07-01

    The conference included three plenary sessions. The plenary on Governance, Security, Economy, and the Ecosystem of the Changing Arctic featured Vera Alexander, president, Arctic Research Consortium of the U.S.; Alan Thornhill, chief environmental officer, U.S. Department of the Interior's Bureau of Ocean Energy Management; and Fran Ulmer, chair, U.S. Arctic Research Commission. A plenary on the U.N. Convention on the Law of the Sea featured Ambassador David Balton, deputy assistant secretary for oceans and fisheries, U.S. Department of State; and Rear Admiral Frederick Kenney Jr., judge advocate general and chief counsel, U.S. Coast Guard. The plenary on Science and the 21st Century featured Phil Keslin, chief technology officer, small lab within Google.

  12. Advanced planetary studies

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Results of planetary advanced studies and planning support are summarized. The scope of analyses includes cost estimation research, planetary mission performance, penetrator advanced studies, Mercury mission transport requirements, definition of super solar electric propulsion/solar sail mission discriminators, and advanced planning activities.

  13. Advanced Pacemaker

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Synchrony, developed by St. Jude Medical's Cardiac Rhythm Management Division (formerly known as Pacesetter Systems, Inc.) is an advanced state-of-the-art implantable pacemaker that closely matches the natural rhythm of the heart. The companion element of the Synchrony Pacemaker System is the Programmer Analyzer APS-II which allows a doctor to reprogram and fine tune the pacemaker to each user's special requirements without surgery. The two-way communications capability that allows the physician to instruct and query the pacemaker is accomplished by bidirectional telemetry. APS-II features 28 pacing functions and thousands of programming combinations to accommodate diverse lifestyles. Microprocessor unit also records and stores pertinent patient data up to a year.

  14. Editorial: Latest methods and advances in biotechnology.

    PubMed

    Lee, Sang Yup; Jungbauer, Alois

    2014-01-01

    The latest "Biotech Methods and Advances" special issue of Biotechnology Journal continues the BTJ tradition of featuring the latest breakthroughs in biotechnology. The special issue is edited by our Editors-in-Chief, Prof. Sang Yup Lee and Prof. Alois Jungbauer and covers a wide array of topics in biotechnology, including the perennial favorite workhorses of the biotech industry, Chinese hamster ovary (CHO) cell and Escherichia coli.

  15. Complex Topographic Feature Ontology Patterns

    USGS Publications Warehouse

    Varanka, Dalia E.; Jerris, Thomas J.

    2015-01-01

    Semantic ontologies are examined as effective data models for the representation of complex topographic feature types. Complex feature types are viewed as integrated relations between basic features for a basic purpose. In the context of topographic science, such component assemblages are supported by resource systems and found on the local landscape. Ontologies are organized within six thematic modules of a domain ontology called Topography that includes within its sphere basic feature types, resource systems, and landscape types. Context is constructed not only as a spatial and temporal setting, but a setting also based on environmental processes. Types of spatial relations that exist between components include location, generative processes, and description. An example is offered in a complex feature type ‘mine.’ The identification and extraction of complex feature types are an area for future research.

  16. Challenges of advanced hepatocellular carcinoma.

    PubMed

    Colagrande, Stefano; Inghilesi, Andrea L; Aburas, Sami; Taliani, Gian G; Nardi, Cosimo; Marra, Fabio

    2016-09-14

    Hepatocellular carcinoma (HCC) is an aggressive malignancy, resulting as the third cause of death by cancer each year. The management of patients with HCC is complex, as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging, clinical and biochemical parameters is routinely performed, a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice, several phase III clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Loco-regional therapies have also been tested as first line treatment, but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally, robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. PMID:27678348

  17. Challenges of advanced hepatocellular carcinoma

    PubMed Central

    Colagrande, Stefano; Inghilesi, Andrea L; Aburas, Sami; Taliani, Gian G; Nardi, Cosimo; Marra, Fabio

    2016-01-01

    Hepatocellular carcinoma (HCC) is an aggressive malignancy, resulting as the third cause of death by cancer each year. The management of patients with HCC is complex, as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging, clinical and biochemical parameters is routinely performed, a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice, several phase III clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Loco-regional therapies have also been tested as first line treatment, but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally, robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials.

  18. Challenges of advanced hepatocellular carcinoma

    PubMed Central

    Colagrande, Stefano; Inghilesi, Andrea L; Aburas, Sami; Taliani, Gian G; Nardi, Cosimo; Marra, Fabio

    2016-01-01

    Hepatocellular carcinoma (HCC) is an aggressive malignancy, resulting as the third cause of death by cancer each year. The management of patients with HCC is complex, as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging, clinical and biochemical parameters is routinely performed, a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice, several phase III clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Loco-regional therapies have also been tested as first line treatment, but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally, robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. PMID:27678348

  19. Multicultural Resources: Including Technology and the Internet

    ERIC Educational Resources Information Center

    Burton, Bryan

    2004-01-01

    In the fourteen years since the 1990 MENC pre-conference symposium on Multicultural Approaches to Music Education in Washington, D.C., music educators have come to recognize the need to include a variety of world musics in all music curricula, from elementary classrooms to advanced performing ensembles. Accordingly, a significant increase in the…

  20. Geological features that contribute to ground control problems in underground coal mines. Information circular/1993

    SciTech Connect

    Shea-Albin, V.R.

    1993-01-01

    A major portion of ground control problems encountered in underground coal mines can be attributed to geologic features in the strata surrounding the extracted coal seam. The U.S. Bureau of Mines has compiled information from several sources on the geological features that contribute to ground control problems in underground coal mines. The compilation includes sedimentary features such as paleochannels, crevasse splays, clastic dikes, mold and cast structures, concretions, lithologic factors, and structural features, such as folds, fractures, joints, cleat, and faults. The compiled information will aid in identifying the features, predicting their occurrence in advance of mining, and controlling or minimizing roof failure when these features are encountered in an underground coal mine.

  1. Advanced solar dynamic technology program

    NASA Technical Reports Server (NTRS)

    Calogeras, James

    1990-01-01

    Viewgraphs and discussion on Advanced Solar Dynamic Technology Program are presented. Topics covered include: advanced solar dynamic technology program; advanced concentrators; advanced heat receivers; power conversion systems; dished all metal honeycomb sandwich panels; Stirling cavity heat pipe receiver; Brayton solar receiver; and thermal energy storage technology.

  2. An Integrated Biochemistry Laboratory, Including Molecular Modeling

    NASA Astrophysics Data System (ADS)

    Hall, Adele J. Wolfson Mona L.; Branham, Thomas R.

    1996-11-01

    The dilemma of designing an advanced undergraduate laboratory lies in the desire to teach and reinforce basic principles and techniques while at the same time exposing students to the excitement of research. We report here on a one-semester, project-based biochemistry laboratory that combines the best features of a cookbook approach (high success rate, achievement of defined goals) with those of an investigative, discovery-based approach (student involvement in the experimental design, excitement of real research). Individual modules may be selected and combined to meet the needs of different courses and different institutions. The central theme of this lab is protein purification and design. This laboratory accompanies the first semester of biochemistry (Structure and Function of Macromolecules, a course taken mainly by junior and senior chemistry and biological chemistry majors). The protein chosen as the object of study is the enzyme lysozyme, which is utilized in all projects. It is suitable for a student lab because it is easily and inexpensively obtained from egg white and is extremely stable, and its high isoelectric point (pI = 11) allows for efficient separation from other proteins by ion-exchange chromatography. Furthermore, a literature search conducted by the resourceful student reveals a wealth of information, since lysozyme has been the subject of numerous studies. It was the first enzyme whose structure was determined by crystallography (1). Hendrickson et al. (2) have previously described an intensive one-month laboratory course centered around lysozyme, although their emphasis is on protein stability rather than purification and engineering. Lysozyme continues to be the focus of much exciting new work on protein folding and dynamics, structure and activity (3 - 5). This lab course includes the following features: (i) reinforcement of basic techniques, such as preparation of buffers, simple enzyme kinetics, and absorption spectroscopy; (ii

  3. qFeature

    2015-09-14

    This package contains statistical routines for extracting features from multivariate time-series data which can then be used for subsequent multivariate statistical analysis to identify patterns and anomalous behavior. It calculates local linear or quadratic regression model fits to moving windows for each series and then summarizes the model coefficients across user-defined time intervals for each series. These methods are domain agnostic—but they have been successfully applied to a variety of domains, including commercial aviation andmore » electric power grid data.« less

  4. qFeature

    SciTech Connect

    2015-09-14

    This package contains statistical routines for extracting features from multivariate time-series data which can then be used for subsequent multivariate statistical analysis to identify patterns and anomalous behavior. It calculates local linear or quadratic regression model fits to moving windows for each series and then summarizes the model coefficients across user-defined time intervals for each series. These methods are domain agnostic—but they have been successfully applied to a variety of domains, including commercial aviation and electric power grid data.

  5. Spinoff 2001: Special Millennium Feature

    NASA Technical Reports Server (NTRS)

    2001-01-01

    For the past 43 years, NASA has devoted its facilities, labor force, and expertise to sharing the abundance of technology developments used for its missions with the nation's industries. These countless technologies have not only successfully contributed to the growth of the U.S. economy, but also to the quality of life on Earth. For the past 25 years, NASA's Spinoff publication has brought attention to thousands of technologies, products, and services that were developed as a direct result of commercial partnerships between NASA and the private business sector. Many of these exciting technologies included advances in ceramics, computer technology, fiber optics, and remote sensing. New and ongoing research at the NASA field centers covers a full spectrum of technologies that will provide numerous advantages for the future, many of which have made significant strides in the commercial market. The NASA Commercial Technology Network plays a large role in transferring this progress. By applying NASA technologies such as data communication, aircraft de-icing technologies, and innovative materials to everyday functions, American consumers and the national economy benefit. Moving forward into the new millennium, these new technologies will further advance our country's position as the world leader in scientific and technical innovation. These cutting-edge innovations represent the investment of the U.S. citizen in the Space Program. Some of these technologies are highlighted in Spinoff 2001, an example of NASA's commitment to technology transfer and commercialization assistance. This year's issue spotlights the commercial technology efforts of NASA's John F. Kennedy Space Center. Kennedy's extensive network of commercial technology opportunities has enabled them to become a leader in technology transfer outreach. This kind of leadership is exemplified through Kennedy's recent partnership with the State of Florida, working toward the development of the Space Experiment

  6. A case of thoracic giant cell tumor of bone and discussion of radiological features and current management practices.

    PubMed

    Kelly, Deirdre; Mc Erlean, Sarah; Byrne, Danielle; Mahon, Peter Mac; Mc Caffrey, John

    2016-09-01

    Giant cell tumor of bone (GCTB) is a rare condition with distinct radiological features that aid diagnosis. We present the case of an adult female patient, with locally invasive GCTB and review important radiological and management principles. Specific radiological features include locally aggressive, lytic radiolucent lesions, which can demonstrate cortical thinning and expansile remodeling of bone and typically involve the epiphysis and metaphysis. Management is primarily surgical, and denosumab has a role in the advanced setting. PMID:27594954

  7. Advanced Manufacturing Technologies

    NASA Technical Reports Server (NTRS)

    Fikes, John

    2016-01-01

    Advanced Manufacturing Technologies (AMT) is developing and maturing innovative and advanced manufacturing technologies that will enable more capable and lower-cost spacecraft, launch vehicles and infrastructure to enable exploration missions. The technologies will utilize cutting edge materials and emerging capabilities including metallic processes, additive manufacturing, composites, and digital manufacturing. The AMT project supports the National Manufacturing Initiative involving collaboration with other government agencies.

  8. Advanced Life Support

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe

    2004-01-01

    Viewgraphs on Advanced Life Support (ALS) Systems are presented. The topics include: 1) Fundamental Need for Advanced Life Support; 2) ALS organization; 3) Requirements and Rationale; 4) Past Integrated tests; 5) The need for improvements in life support systems; 6) ALS approach to meet exploration goals; 7) ALS Projects showing promise to meet exploration goals; and 9) GRC involvement in ALS.

  9. Advanced turbine blade tip seal system

    NASA Technical Reports Server (NTRS)

    Zelahy, J. W.

    1981-01-01

    An advanced blade/shroud system designed to maintain close clearance between blade tips and turbine shrouds and at the same time, be resistant to environmental effects including high temperature oxidation, hot corrosion, and thermal cycling is described. Increased efficiency and increased blade life are attained by using the advanced blade tip seal system. Features of the system include improved clearance control when blade tips preferentially wear the shrouds and a superior single crystal superalloy tip. The tip design, joint location, characterization of the single crystal tip alloy, the abrasive tip treatment, and the component and engine test are among the factors addressed. Results of wear testing, quality control plans, and the total manufacturing cycle required to fully process the blades are also discussed.

  10. Building Model NASA Satellites: Elementary Students Studying Science Using a NASA-Themed Transmedia Book Featuring Digital Fabrication Activities

    ERIC Educational Resources Information Center

    Tillman, Daniel; An, Song; Boren, Rachel; Slykhuis, David

    2014-01-01

    This study assessed the impact of nine lessons incorporating a NASA-themed transmedia book featuring digital fabrication activities on 5th-grade students (n = 29) recognized as advanced in mathematics based on their academic record. Data collected included a pretest and posttest of science content questions taken from released Virginia Standards…

  11. Spatial features register: toward standardization of spatial features

    USGS Publications Warehouse

    Cascio, Janette

    1994-01-01

    As the need to share spatial data increases, more than agreement on a common format is needed to ensure that the data is meaningful to both the importer and the exporter. Effective data transfer also requires common definitions of spatial features. To achieve this, part 2 of the Spatial Data Transfer Standard (SDTS) provides a model for a spatial features data content specification and a glossary of features and attributes that fit this model. The model provides a foundation for standardizing spatial features. The glossary now contains only a limited subset of hydrographic and topographic features. For it to be useful, terms and definitions must be included for other categories, such as base cartographic, bathymetric, cadastral, cultural and demographic, geodetic, geologic, ground transportation, international boundaries, soils, vegetation, water, and wetlands, and the set of hydrographic and topographic features must be expanded. This paper will review the philosophy of the SDTS part 2 and the current plans for creating a national spatial features register as one mechanism for maintaining part 2.

  12. Advances in cancer control

    SciTech Connect

    Anderson, P.N. ); Engstrom, P.F. ); Mortenson, L.E. )

    1989-01-01

    This book contains the proceedings of the sixth annual meeting on Advances in Cancer Control. Included are the following articles: Barriers and facilitators to compliance with routine mammographic screening, Preliminary report of an intervention to improve mammography skills of radiologists.

  13. Advances in cell culture

    SciTech Connect

    Maramorosch, K. )

    1987-01-01

    This book presents papers on advances in cell culture. Topics covered include: Genetic changes in the influenza viruses during growth in cultured cells; The biochemistry and genetics of mosquito cells in culture; and Tree tissue culture applications.

  14. The Enigmatic Thirteen Micron Feature

    NASA Astrophysics Data System (ADS)

    de Queiroz e Souza, Nelson

    Low and intermediate mass stars (0.8--8 solar masses) will eventually evolve into Asymptotic Giant Branch (AGB) stars and pulsate out their atmosphere into the space around them. That ejected material will eventually cool and form dust. Understanding the nature and formation of cosmic dust is crucial to understanding the Universe. Evolved intermediate mass stars (i.e. AGB stars) are major contributors of dust to the cosmos. Dust around AGB stars are studied by means of infrared spectroscopy from which we observe several interesting spectral features. The observed AGB star spectra have been classified according to their shapes and wavelength positions of the dust features. Alongside the main spectral features around 8-12mum, there is an enigmatic 13mum feature that appears in about half the oxygen-rich AGB stars. The carrier of this feature has not yet been unequivocally identified but has been attributed to various dust species, including corundum (crystalline Al2O3), spinel (MgAl2O4), and silica (SiO2). While there have been several attempts to determine the cause of this 13mum feature, previous studies have been somewhat contradictory. In order to investigate the origin and characteristics of this spectral feature we observe variations in the 13mum feature over varying stellar parameters. We have also acquired spatially resolved spectroscopic observations of nearby O-rich AGB stars using Michelle on Gemini North. Here we present data on the 13mum feature strength mapped over space around their respective AGB star. The most popular hypothesis for the carrier of the 13mm feature is not supported by our findings.

  15. Suppression effects in feature-based attention

    PubMed Central

    Wang, Yixue; Miller, James; Liu, Taosheng

    2015-01-01

    Attending to a feature enhances visual processing of that feature, but it is less clear what occurs to unattended features. Single-unit recording studies in middle temporal (MT) have shown that neuronal modulation is a monotonic function of the difference between the attended and neuron's preferred direction. Such a relationship should predict a monotonic suppressive effect in psychophysical performance. However, past research on suppressive effects of feature-based attention has remained inconclusive. We investigated the suppressive effect for motion direction, orientation, and color in three experiments. We asked participants to detect a weak signal among noise and provided a partially valid feature cue to manipulate attention. We measured performance as a function of the offset between the cued and signal feature. We also included neutral trials where no feature cues were presented to provide a baseline measure of performance. Across three experiments, we consistently observed enhancement effects when the target feature and cued feature coincided and suppression effects when the target feature deviated from the cued feature. The exact profile of suppression was different across feature dimensions: Whereas the profile for direction exhibited a “rebound” effect, the profiles for orientation and color were monotonic. These results demonstrate that unattended features are suppressed during feature-based attention, but the exact suppression profile depends on the specific feature. Overall, the results are largely consistent with neurophysiological data and support the feature-similarity gain model of attention. PMID:26067533

  16. Advanced planetary studies

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Results of planetary advanced studies and planning support provided by Science Applications, Inc. staff members to Earth and Planetary Exploration Division, OSSA/NASA, for the period 1 February 1981 to 30 April 1982 are summarized. The scope of analyses includes cost estimation, planetary missions performance, solar system exploration committee support, Mars program planning, Galilean satellite mission concepts, and advanced propulsion data base. The work covers 80 man-months of research. Study reports and related publications are included in a bibliography section.

  17. Advanced Welding Applications

    NASA Technical Reports Server (NTRS)

    Ding, Robert J.

    2010-01-01

    Some of the applications of advanced welding techniques are shown in this poster presentation. Included are brief explanations of the use on the Ares I and Ares V launch vehicle and on the Space Shuttle Launch vehicle. Also included are microstructural views from four advanced welding techniques: Variable Polarity Plasma Arc (VPPA) weld (fusion), self-reacting friction stir welding (SR-FSW), conventional FSW, and Tube Socket Weld (TSW) on aluminum.

  18. Chronic lymphocytic leukemia: a clinical review including Korean cohorts

    PubMed Central

    Jeon, Young-Woo; Cho, Seok-Goo

    2016-01-01

    Only 5th decade ago, chronic lymphocytic leukemia (CLL) was only recognized as disease group of presenting features like peripheral lymphocytosis, organomegaly including of splenomegaly. As understanding of disease biology and molecular diagnostic tools are getting improved gradually, characterization of variation in CLL’s clinical courses was facilitated, resulting in better risk stratification and targeted treatments. Consequently multiple new targeted agents have been used in treatment of CLL, it makes improved clinical outcome. Rituximab containing chemoimmunotherapy (combination of rituximab, fludarabine, and cyclophosphamide) have shown better overall response rate and progression-free survival on fit patients’ group in front-line setting, result in standard first-line therapeutic option for CLL. Furthermore, after introducing that the B-cell receptor is crucial for the evolution and progression of CLL, emerging treatments targeting highly activated surface antigens and oncogenic signaling pathways have been associated with several successes in recent decades. These include new anti-CD 20 monoclonal antibody (obinutuzumab), the bruton tyrosine kinase inhibitor (ibrutinib), the phosphatidylinositol 3-kinase inhibitor (idelalisib), and B-cell CLL/lymphoma 2 inhibitor (ABT-199 and ABT-263). So, we discuss not only general pathophysiology of CLL, but also rapidly advancing treatment strategies that are being studied or approved for treatment of CLL. PMID:27044858

  19. New microbiological features.

    PubMed

    Lee, A

    1995-04-01

    Recent developments in the microbiology of Helicobacter pylori have aimed to improve our understanding of the organism in order to define better methods of diagnosis and cure, and to explore possible methods of prevention. Investigations of the basic biochemistry of the bacterium have revealed many interesting physiological anomalies including characteristics of a eukaryotic parasite rather than a bacterium. The latest in a growing list of adhesins to be identified shows specificity for the Lewis b antigen, possibly providing an explanation for the postulated link between blood group and peptic ulceration. However, there are many contradictory features in the H. pylori adhesin story in urgent need of resolution. The search for the ulcerogenic strain has revealed only one possible candidate to date, the cagA phenotype, which appears to be inflammatory. Recently, the cloning frenzy has resulted in the sequencing of a multitude of putative virulence factors, the challenge now is to prove their importance in relevant animal models. PMID:7600134

  20. Advanced midwifery practice or advancing midwifery practice?

    PubMed

    Smith, Rachel; Leap, Nicky; Homer, Caroline

    2010-09-01

    Advanced midwifery practice is a controversial notion in midwifery, particularly at present in Australia. The proposed changes in legislation around access to the publicly funded Medical Benefits Scheme (MBS) and the Pharmaceutical Benefits Scheme (PBS) in 2009-2010 have meant that the issue of advanced midwifery practice has again taken prominence. Linking midwifery access to MBS and PBS to a safety and quality framework that includes an 'advanced midwifery credentialling framework' is particularly challenging. The Haxton and Fahy paper in the December 2009 edition of Women and Birth is timely as it enables a reflection upon these issues and encourages debate and discussion about exactly what is midwifery, what are we educating our students for and is working to the full scope of practice practising at advanced level? This paper seeks to address some of these questions and open up the topic for further debate.

  1. A review of advanced turboprop transport aircraft

    NASA Astrophysics Data System (ADS)

    Lange, Roy H.

    The application of advanced technologies shows the potential for significant improvement in the fuel efficiency and operating costs of future transport aircraft envisioned for operation in the 1990s time period. One of the more promising advanced technologies is embodied in an advanced turboprop concept originated by Hamilton Standard and NASA and known as the propfan. The propfan concept features a highly loaded multibladed, variable pitch propeller geared to a high pressure ratio gas turbine engine. The blades have high sweepback and advanced airfoil sections to achieve 80 percent propulsive efficiency at M=0.80 cruise speed. Aircraft system studies have shown improvements in fuel efficiency of 15-20 percent for propfan advanced transport aircraft as compared to equivalent turbofan transports. Beginning with the Lockheed C-130 and Electra turboprop aircraft, this paper presents an overview of the evolution of propfan aircraft design concepts and system studies. These system studies include possible civil and military transport applications and data on the performance, community and far-field noise characteristics and operating costs of propfan aircraft design concepts. NASA Aircraft Energy Efficiency (ACEE) program propfan projects with industry are reviewed with respect to system studies of propfan aircraft and recommended flight development programs.

  2. Three-dimensional viscous design methodology for advanced technology aircraft supersonic inlet systems

    NASA Technical Reports Server (NTRS)

    Anderson, B. H.

    1983-01-01

    A broad program to develop advanced, reliable, and user oriented three-dimensional viscous design techniques for supersonic inlet systems, and encourage their transfer into the general user community is discussed. Features of the program include: (1) develop effective methods of computing three-dimensional flows within a zonal modeling methodology; (2) ensure reasonable agreement between said analysis and selective sets of benchmark validation data; (3) develop user orientation into said analysis; and (4) explore and develop advanced numerical methodology.

  3. Low voltage 30-cm ion thruster development. [including performance and structural integrity (vibration) tests

    NASA Technical Reports Server (NTRS)

    King, H. J.

    1974-01-01

    The basic goal was to advance the development status of the 30-cm electron bombardment ion thruster from a laboratory model to a flight-type engineering model (EM) thruster. This advancement included the more conventional aspects of mechanical design and testing for launch loads, weight reduction, fabrication process development, reliability and quality assurance, and interface definition, as well as a relatively significant improvement in thruster total efficiency. The achievement of this goal was demonstrated by the successful completion of a series of performance and structural integrity (vibration) tests. In the course of the program, essentially every part and feature of the original 30-cm Thruster was critically evaluated. These evaluations, led to new or improved designs for the ion optical system, discharge chamber, cathode isolator vaporizer assembly, main isolator vaporizer assembly, neutralizer assembly, packaging for thermal control, electrical terminations and structure.

  4. Advanced propulsion for LEO-Moon transport. 1: A method for evaluating advanced propulsion performance

    NASA Technical Reports Server (NTRS)

    Stern, Martin O.

    1992-01-01

    This report describes a study to evaluate the benefits of advanced propulsion technologies for transporting materials between low Earth orbit and the Moon. A relatively conventional reference transportation system, and several other systems, each of which includes one advanced technology component, are compared in terms of how well they perform a chosen mission objective. The evaluation method is based on a pairwise life-cycle cost comparison of each of the advanced systems with the reference system. Somewhat novel and economically important features of the procedure are the inclusion not only of mass payback ratios based on Earth launch costs, but also of repair and capital acquisition costs, and of adjustments in the latter to reflect the technological maturity of the advanced technologies. The required input information is developed by panels of experts. The overall scope and approach of the study are presented in the introduction. The bulk of the paper describes the evaluation method; the reference system and an advanced transportation system, including a spinning tether in an eccentric Earth orbit, are used to illustrate it.

  5. Advances in ice mechanics - 1987

    SciTech Connect

    Chung, J.S.; Hallam, S.D.; Maatanen, M.; Sinha, N.K.; Sodhi, D.S.

    1987-01-01

    This book presents the papers given at a symposium on the interaction of icebergs with offshore platforms. Topics considered at the symposium included advances in ice mechanics in the United Kingdom, ice mechanics in Finland, recent advances in ice mechanics in Canada, advances in sea ice mechanics in the USA, foundations, monitoring, hazards, risk assessment, and deformation.

  6. Advanced supersonic propulsion study, phase 4

    NASA Technical Reports Server (NTRS)

    Howlett, R. A.

    1977-01-01

    Installation characteristics for a Variable Stream Control Engine (VSCE) were studied for three advanced supersonic airplane designs. Sensitivity of the VSCE concept to change in technology projections was evaluated in terms of impact on overall installed performance. Based on these sensitivity results, critical technology requirements were reviewed, resulting in the reaffirmation of the following requirements: low-noise nozzle system; a high performance, low emissions duct burner and main burner; hot section technology; variable geometry components; and propulsion integration features, including an integrated electronic control system.

  7. Advanced Solid Rocket Motor case design status

    NASA Technical Reports Server (NTRS)

    Palmer, G. L.; Cash, S. F.; Beck, J. P.

    1993-01-01

    The Advanced Solid Rocket Motor (ASRM) case design aimed at achieving a safer and more reliable solid rocket motor for the Space Shuttle system is considered. The ASRM case has a 150.0 inch diameter, three equal length segment, and 9Ni-4CO-0.3C steel alloy. The major design features include bolted casebolted case joints which close during pressurization, plasma arc welded factory joints, integral stiffener for splash down and recovery, and integral External Tank attachment rings. Each mechanical joint has redundant and verifiable o-ring seals.

  8. Rotorcraft Digital Advanced Avionics System (rodaas)

    NASA Technical Reports Server (NTRS)

    Taira, B.

    1985-01-01

    A simulator is being built to determine the practicality of using an advanced avionics system in a helicopter. Features include an autopilot; a navigation and flight planning component; an advisory system built into the computer; conventional gages and displays; a clock function; a fuel totalizer; a weight and balance computator; a performance evaluator; and emergency and normal checklists. The translation of a computer program written in PASCAL into a form that can be read by the graphics package for the simulator and basic electronic work in simulator construction are discussed.

  9. Advanced Manufacturing Systems in Food Processing and Packaging Industry

    NASA Astrophysics Data System (ADS)

    Shafie Sani, Mohd; Aziz, Faieza Abdul

    2013-06-01

    In this paper, several advanced manufacturing systems in food processing and packaging industry are reviewed, including: biodegradable smart packaging and Nano composites, advanced automation control system consists of fieldbus technology, distributed control system and food safety inspection features. The main purpose of current technology in food processing and packaging industry is discussed due to major concern on efficiency of the plant process, productivity, quality, as well as safety. These application were chosen because they are robust, flexible, reconfigurable, preserve the quality of the food, and efficient.

  10. Earth Observing-1 Advanced Land Imager: Radiometric Response Calibration

    NASA Technical Reports Server (NTRS)

    Mendenhall, J. A.; Lencioni, D. E.; Evans, J. B.

    2000-01-01

    The Advanced Land Imager (ALI) is one of three instruments to be flown on the first Earth Observing mission (EO-1) under NASA's New Millennium Program (NMP). ALI contains a number of innovative features, including a wide field of view optical design, compact multispectral focal plane arrays, non-cryogenic HgCdTe detectors for the short wave infrared bands, and silicon carbide optics. This document outlines the techniques adopted during ground calibration of the radiometric response of the Advanced Land Imager. Results from system level measurements of the instrument response, signal-to-noise ratio, saturation radiance, and dynamic range for all detectors of every spectral band are also presented.

  11. YGA: identifying distinct biological features between yeast gene sets.

    PubMed

    Chang, Darby Tien-Hao; Li, Wen-Si; Bai, Yi-Han; Wu, Wei-Sheng

    2013-04-10

    The advance of high-throughput experimental technologies generates many gene sets with different biological meanings, where many important insights can only be extracted by identifying the biological (regulatory/functional) features that are distinct between different gene sets (e.g. essential vs. non-essential genes, TATA box-containing vs. TATA box-less genes, induced vs. repressed genes under certain biological conditions). Although many servers have been developed to identify enriched features in a gene set, most of them were designed to analyze one gene set at a time but cannot compare two gene sets. Moreover, the features used in existing servers were mainly focused on functional annotations (GO terms), pathways, transcription factor binding sites (TFBSs) and/or protein-protein interactions (PPIs). In yeast, various important regulatory features, including promoter bendability, nucleosome occupancy, 5'-UTR length, and TF-gene regulation evidence, are available but have not been used in any enrichment analysis servers. This motivates us to develop the Yeast Genes Analyzer (YGA), a web server that simultaneously analyzes various biological (regulatory/functional) features of two gene sets and performs statistical tests to identify the distinct features between them. Many well-studied gene sets such as essential, stress-response, TATA box-containing and cell cycle genes were pre-compiled in YGA for users, if they have only one gene set, to compare with. In comparison with the existing enrichment analysis servers, YGA tests more comprehensive regulatory features (e.g. promoter bendability, nucleosome occupancy, 5'-UTR length, experimental evidence of TF-gene binding and TF-gene regulation) and functional features (e.g. PPI, GO terms, pathways and functional groups of genes, including essential/non-essential genes, stress-induced/-repressed genes, TATA box-containing/-less genes, occupied/depleted proximal-nucleosome genes and cell cycle genes). Furthermore, YGA

  12. Advance care directives

    MedlinePlus

    ... advance directive; Do-not-resuscitate - advance directive; Durable power of attorney - advance care directive; POA - advance care directive; Health care agent - advance care directive; Health care proxy - ...

  13. Consumer Controlled Housing. Feature Issue.

    ERIC Educational Resources Information Center

    Skarnulis, Edward, Ed.; Lakin, K. Charlie, Ed.

    1990-01-01

    This "feature issue" reports on consumer-controlled housing for persons with developmental disabilities, and explores housing and service options that empower individuals with disabilities to live their lives with independence, privacy, and freedom of choice. It includes an excerpt from the Association for Retarded Citizens position statement on…

  14. Advanced Chemical Propulsion Study

    NASA Technical Reports Server (NTRS)

    Woodcock, Gordon; Byers, Dave; Alexander, Leslie A.; Krebsbach, Al

    2004-01-01

    A study was performed of advanced chemical propulsion technology application to space science (Code S) missions. The purpose was to begin the process of selecting chemical propulsion technology advancement activities that would provide greatest benefits to Code S missions. Several missions were selected from Code S planning data, and a range of advanced chemical propulsion options was analyzed to assess capabilities and benefits re these missions. Selected beneficial applications were found for higher-performing bipropellants, gelled propellants, and cryogenic propellants. Technology advancement recommendations included cryocoolers and small turbopump engines for cryogenic propellants; space storable propellants such as LOX-hydrazine; and advanced monopropellants. It was noted that fluorine-bearing oxidizers offer performance gains over more benign oxidizers. Potential benefits were observed for gelled propellants that could be allowed to freeze, then thawed for use.

  15. Automatic extraction of planetary image features

    NASA Technical Reports Server (NTRS)

    LeMoigne-Stewart, Jacqueline J. (Inventor); Troglio, Giulia (Inventor); Benediktsson, Jon A. (Inventor); Serpico, Sebastiano B. (Inventor); Moser, Gabriele (Inventor)

    2013-01-01

    A method for the extraction of Lunar data and/or planetary features is provided. The feature extraction method can include one or more image processing techniques, including, but not limited to, a watershed segmentation and/or the generalized Hough Transform. According to some embodiments, the feature extraction method can include extracting features, such as, small rocks. According to some embodiments, small rocks can be extracted by applying a watershed segmentation algorithm to the Canny gradient. According to some embodiments, applying a watershed segmentation algorithm to the Canny gradient can allow regions that appear as close contours in the gradient to be segmented.

  16. Cirrhosis Classification Based on Texture Classification of Random Features

    PubMed Central

    Shao, Ying; Guo, Dongmei; Zheng, Yuanjie; Zhao, Zuowei; Qiu, Tianshuang

    2014-01-01

    Accurate staging of hepatic cirrhosis is important in investigating the cause and slowing down the effects of cirrhosis. Computer-aided diagnosis (CAD) can provide doctors with an alternative second opinion and assist them to make a specific treatment with accurate cirrhosis stage. MRI has many advantages, including high resolution for soft tissue, no radiation, and multiparameters imaging modalities. So in this paper, multisequences MRIs, including T1-weighted, T2-weighted, arterial, portal venous, and equilibrium phase, are applied. However, CAD does not meet the clinical needs of cirrhosis and few researchers are concerned with it at present. Cirrhosis is characterized by the presence of widespread fibrosis and regenerative nodules in the hepatic, leading to different texture patterns of different stages. So, extracting texture feature is the primary task. Compared with typical gray level cooccurrence matrix (GLCM) features, texture classification from random features provides an effective way, and we adopt it and propose CCTCRF for triple classification (normal, early, and middle and advanced stage). CCTCRF does not need strong assumptions except the sparse character of image, contains sufficient texture information, includes concise and effective process, and makes case decision with high accuracy. Experimental results also illustrate the satisfying performance and they are also compared with typical NN with GLCM. PMID:24707317

  17. Advanced ramjet concepts program

    NASA Technical Reports Server (NTRS)

    Leingang, J. L.

    1992-01-01

    Uniquely advantageous features, on both the performance and weight sides of the ledger, can be achieved through synergistic design integration of airbreathing and rocket technologies in the development of advanced orbital space transport propulsion systems of the combined cycle type. In the context of well understood advanced airbreathing and liquid rocket propulsion principles and practices, this precept of synergism is advanced mainly through six rather specific examples. These range from the detailed component level to the overall vehicle system level as follows: using jet compression; achieving a high area ratio rocket nozzle; ameliorating gas generator cycle rocket system deficiencies; using the in-duct special rocket thrust chamber assembly as the principal scramjet fuel injection operation; using the unstowed, covered fan as a duct closure for effecting high area ratio rocket mode operation; and creating a unique airbreathing rocket system via the onboard, cryogenic hydrogen induced air liquefaction process.

  18. Innovative safety features of the modular HTGR

    SciTech Connect

    Silady, F.A.; Simon, W.A.

    1992-01-01

    The Modular High Temperature Gas-Cooled Reactor (MHTGR) is an advanced reactor concept under development through a cooperative program involving the US Government, the nuclear industry, and the utilities. Near-term development is focused on electricity generation. The top-level safety requirement is that the plant's operation not disturb the normal day-to-day activities of the public. Quantitatively, this requires that the design meet the US Environmental Protection Agency's Protective Action Guides at the site boundary and hence preclude the need for sheltering or evacuation of the public. To meet these stringent safety requirements and at the same time provide a cost competitive design requires the innovative use of the basic high temperature gas-cooled reactor features of ceramic fuel, helium coolant, and a graphite moderator. The specific fuel composition and core size and configuration have been selected to the use the natural characteristics of these materials to develop significantly higher margins of safety. In this document the innovative safety features of the MHTGR are reviewed by examining the safety response to events challenging the functions relied on to retain radionuclides within the coated fuel particles. A broad range of challenges to core heat removal are examined, including a loss of helium pressure of a simultaneous loss of forced cooling of the core. The challenges to control of heat generation consider not only the failure to insert the reactivity control systems but also the withdrawal of control rods. Finally, challenges to control of chemical attack of the ceramic-coated fuel are considered, including catastrophic failure of the steam generator, which allows water ingress, or failure of the pressure vessels, which allows air ingress. The plant's response to these extreme challenges is not dependent on operator action, and the events considered encompass conceivable operator errors.

  19. Innovative safety features of the modular HTGR

    SciTech Connect

    Silady, F.A.; Simon, W.A.

    1992-01-01

    The Modular High Temperature Gas-Cooled Reactor (MHTGR) is an advanced reactor concept under development through a cooperative program involving the US Government, the nuclear industry, and the utilities. Near-term development is focused on electricity generation. The top-level safety requirement is that the plant`s operation not disturb the normal day-to-day activities of the public. Quantitatively, this requires that the design meet the US Environmental Protection Agency`s Protective Action Guides at the site boundary and hence preclude the need for sheltering or evacuation of the public. To meet these stringent safety requirements and at the same time provide a cost competitive design requires the innovative use of the basic high temperature gas-cooled reactor features of ceramic fuel, helium coolant, and a graphite moderator. The specific fuel composition and core size and configuration have been selected to the use the natural characteristics of these materials to develop significantly higher margins of safety. In this document the innovative safety features of the MHTGR are reviewed by examining the safety response to events challenging the functions relied on to retain radionuclides within the coated fuel particles. A broad range of challenges to core heat removal are examined, including a loss of helium pressure of a simultaneous loss of forced cooling of the core. The challenges to control of heat generation consider not only the failure to insert the reactivity control systems but also the withdrawal of control rods. Finally, challenges to control of chemical attack of the ceramic-coated fuel are considered, including catastrophic failure of the steam generator, which allows water ingress, or failure of the pressure vessels, which allows air ingress. The plant`s response to these extreme challenges is not dependent on operator action, and the events considered encompass conceivable operator errors.

  20. Advanced biostack experiment

    NASA Technical Reports Server (NTRS)

    Buecker, H.

    1981-01-01

    The Advanced Biostack Experiment is described. The objectives are: (1) to confirm, complement, and enlarge the information obtained from the previous experiments by applying improved and advanced methods of localization and physical and biological evaluation, performing advanced experiments based on these data, and including additional biological specimens and additional radiation detectors; (2) to determine the biological importance of nuclear disintegration stars; (3) to determine the interference of HZE particle induced effects with those of other space flight factors (e.g., weightlessness); and (4) to determine the distribution of HZE particles and of disintegration stars at different locations inside the module and on the pallet.

  1. Rapid characterization of titanium microstructural features for specific modelling of mechanical properties

    NASA Astrophysics Data System (ADS)

    Searles, T.; Tiley, J.; Tanner, A.; Williams, R.; Rollins, B.; Lee, E.; Kar, S.; Banerjee, R.; Fraser, H. L.

    2005-01-01

    Mechanical properties of α/β Ti alloys are closely related to their microstructure. The complexity of the microstructural features involved makes it rather difficult to develop models for predicting properties of these alloys. Advances in stereology and microscopy permit rapid characterization of various features in Ti alloys including Widmanstätten α-laths, grain sizes, grain shapes, colony structures and volume fractions of different phases. This research documents the stereology procedures for characterizing microstructural features in Ti alloys, including the use of three-dimensional serial sectioning and reconstruction procedures for developing through material measurements. The resulting data indicate the powerful characterization processes now available, and the ability to rapidly assess microstructural features in Ti alloys. The processes were tested using Ti-62222 by serial sectioning the sample and conducting automated stereology protocols to determine features. In addition, three-dimensional reconstruction was completed on a Ti-6242 sample to evaluate lath interactions within the alloy. Results indicate the tremendous potential for characterizing microstructures using advanced techniques.

  2. Adaptive feature extraction expert

    SciTech Connect

    Yuschik, M.

    1983-01-01

    The identification of discriminatory features places an upper bound on the recognition rate of any automatic speech recognition (ASR) system. One way to structure the extraction of features is to construct an expert system which applies a set of rules to identify particular properties of the speech patterns. However, these patterns vary for an individual speaker and from speaker to speaker so that another expert is actually needed to learn the new variations. The author investigates the problem by using sets of discriminatory features that are suggested by a feature generation expert, improves the selectivity of these features with a training expert, and finally develops a minimally spanning feature set with a statistical selection expert. 12 references.

  3. Advanced space propulsion concepts

    NASA Technical Reports Server (NTRS)

    Lapointe, Michael R.

    1993-01-01

    The NASA Lewis Research Center has been actively involved in the evaluation and development of advanced spacecraft propulsion. Recent program elements have included high energy density propellants, electrode less plasma thruster concepts, and low power laser propulsion technology. A robust advanced technology program is necessary to develop new, cost-effective methods of spacecraft propulsion, and to continue to push the boundaries of human knowledge and technology.

  4. [Advances in hormonal contraception].

    PubMed

    Villanueva Egan, Luis Alberto; Pichardo Cuevas, Mauricio

    2007-01-01

    This review provides an update regarding newer options in hormonal contraception that include the progestin-releasing intrauterine system, the contraceptive patch and ring, the single rod progestin-releasing implant, extended and emergency oral contraception and recent advances in hormonal male contraception. These methods represent a major advancement in this field, allowing for the development of more acceptable, safety and effective birth control regimens.

  5. External facial features modify the representation of internal facial features in the fusiform face area.

    PubMed

    Axelrod, Vadim; Yovel, Galit

    2010-08-15

    Most studies of face identity have excluded external facial features by either removing them or covering them with a hat. However, external facial features may modify the representation of internal facial features. Here we assessed whether the representation of face identity in the fusiform face area (FFA), which has been primarily studied for internal facial features, is modified by differences in external facial features. We presented faces in which external and internal facial features were manipulated independently. Our findings show that the FFA was sensitive to differences in external facial features, but this effect was significantly larger when the external and internal features were aligned than misaligned. We conclude that the FFA generates a holistic representation in which the internal and the external facial features are integrated. These results indicate that to better understand real-life face recognition both external and internal features should be included.

  6. Advanced Remote Maintenance Design for Pilot-Scale Centrifugal Contactors

    SciTech Connect

    Jack Law; David Meikrantz; Troy Garn; Lawrence Macaluso

    2011-02-01

    Advanced designs of used nuclear fuel recycling processes and radioactive waste treatment processes are expected to include more ambitious goals for aqueous based separations including; higher separations efficiency, high-level waste minimization, and a greater focus on continuous processes to minimize cost and footprint. Therefore, annular centrifugal contactors are destined to play a more important role for such future processing schemes. Pilot-scale testing will be an integral part of development of many of these processes. An advanced design for remote maintenance of pilot-scale centrifugal contactors has been developed and a prototype module fabricated and tested for a commercially available pilot-scale centrifugal contactor (CINC V-02, 5-cm rotor diameter). Advanced design features include air actuated clamps for holding the motor-rotor assembly in place, an integral electrical connection, upper flange o-rings, a welded bottom plate, a lifting bale, and guide pins. These design features will allow for rapid replacement of the motor rotor assembly, which can be accomplished while maintaining process equilibrium. Hydraulic testing of a three-stage prototype unit was also performed to verify that design changes did not impact performance of the centrifugal contactors. Details of the pilot-scale remote maintenance design, results of testing in a remote mockup test facility, and results of hydraulic testing of the advanced design are provided.

  7. Advances in Genome Biology & Technology

    SciTech Connect

    Thomas J. Albert, Jon R. Armstrong, Raymond K. Auerback, W. Brad Barbazuk, et al.

    2007-12-01

    This year's meeting focused on the latest advances in new DNA sequencing technologies and the applications of genomics to disease areas in biology and biomedicine. Daytime plenary sessions highlighted cutting-edge research in areas such as complex genetic diseases, comparative genomics, medical sequencing, massively parallel DNA sequencing, and synthetic biology. Technical approaches being developed and utilized in contemporary genomics research were presented during evening concurrent sessions. Also, as in previous years, poster sessions bridged the morning and afternoon plenary sessions. In addition, for the third year in a row, the Advances in Genome Biology and Technology (AGBT) meeting was preceded by a pre-meeting workshop that aimed to provide an introductory overview for trainees and other meeting attendees. This year, speakers at the workshop focused on next-generation sequencing technologies, including their experiences, findings, and helpful advise for others contemplating using these platforms in their research. Speakers from genome centers and core sequencing facilities were featured and the workshop ended with a roundtable discussion, during which speakers fielded questions from the audience.

  8. Clinical features of actinomycosis

    PubMed Central

    Bonnefond, Simon; Catroux, Mélanie; Melenotte, Cléa; Karkowski, Ludovic; Rolland, Ludivine; Trouillier, Sébastien; Raffray, Loic

    2016-01-01

    Abstract Actinomycosis is a rare heterogeneous anaerobic infection with misleading clinical presentations that delay diagnosis. A significant number of misdiagnosed cases have been reported in specific localizations, but studies including various forms of actinomycosis have rarely been published. We performed a multicenter retrospective chart review of laboratory-confirmed actinomycosis cases from January 2000 until January 2014. We described clinical characteristics, diagnostic procedures, differential diagnosis, and management of actinomycosis of clinical significance. Twenty-eight patients were included from 6 hospitals in France. Disease was diagnosed predominately in the abdomen/pelvis (n = 9), orocervicofacial (n = 5), cardiothoracic (n = 5), skeletal (n = 3), hematogenous (n = 3), soft tissue (n = 2), and intracranially (n = 1). Four patients (14%) were immunocompromised. In most cases (92 %), the diagnosis of actinomycosis was not suspected on admission, as clinical features were not specific. Diagnosis was obtained from either microbiology (50%, n = 14) or histopathology (42%, n = 12), or from both methods (7%, n = 2). Surgical biopsy was needed for definite diagnosis in 71% of cases (n = 20). Coinfection was found in 13 patients (46%), among which 3 patients were diagnosed from histologic criteria only. Two-thirds of patients were treated with amoxicillin. Median duration of antibiotics was 120 days (interquartile range 60–180), whereas the median follow-up time was 12 months (interquartile range 5.25–18). Two patients died. This study highlights the distinct and miscellaneous patterns of actinomycosis to prompt accurate diagnosis and earlier treatments, thus improving the outcome. Surgical biopsy should be performed when possible while raising histologist's and microbiologist's awareness of possible actinomycosis to enhance the chance of diagnosis and use specific molecular methods. PMID:27311002

  9. Musculoskeletal mnemonics: differentiating features.

    PubMed

    Currie, Jonathan W; Davis, Kirkland W; Lafita, Vaishali S; Blankenbaker, Donna G; De Smet, Arthur A; Rosas, Humberto; Lee, Kenneth S

    2011-01-01

    Mnemonics are often used in musculoskeletal radiology to help radiologists remember long differential diagnoses. However, unless the specific appearance of each entity on a differential is also recalled, mnemonics become useless. This article presents 8 mnemonics with their corresponding differential diagnoses and distinguishing features. Bubbly lucent lesions of bone are recalled with the FEGNOMASHIC mnemonic, but when only lucent lesions of the diaphysis are included, a more appropriate mnemonic is FEMALE. The lucent lesions of bone differentials often can be narrowed based on specific characteristics of the lesion but radiographic findings elsewhere and clinical information often help. Osseous metastases may present as lucent or sclerotic lesions; when sclerotic, the differential is best remembered with the mnemonic 5 "BEES" Like Pollen. The mnemonic for Wormian bones is PORKCHOPS. The Wormian bones in most of these entities are indistinguishable, so one must rely on radiographic findings outside the skull for diagnosis. By contrast, differentiating causes of acro-osteolysis is often possible with findings seen only on the hand radiographs; the mnemonic for acro-osteolysis is RADSHIP. In skeletally immature patients with frayed metaphyses, the mnemonic is CHARMS. Although the appearance of the fraying is seldom diagnostic, findings in the adjacent portions of the long bones may be characteristic. FETISH is the mnemonic used to remember the entities for the differential diagnosis of vertebra plana. Age of the patient, clinical history, and findings in the adjacent spine often help to provide the specific diagnosis. Nearly all the entities on the differential diagnosis for distal clavicle erosion (mnemonic: SHIRT Pocket) are included in other differentials in this article. PMID:21266270

  10. Feature Selection for Classification of Polar Regions Using a Fuzzy Expert System

    NASA Technical Reports Server (NTRS)

    Penaloza, Mauel A.; Welch, Ronald M.

    1996-01-01

    Labeling, feature selection, and the choice of classifier are critical elements for classification of scenes and for image understanding. This study examines several methods for feature selection in polar regions, including the list, of a fuzzy logic-based expert system for further refinement of a set of selected features. Six Advanced Very High Resolution Radiometer (AVHRR) Local Area Coverage (LAC) arctic scenes are classified into nine classes: water, snow / ice, ice cloud, land, thin stratus, stratus over water, cumulus over water, textured snow over water, and snow-covered mountains. Sixty-seven spectral and textural features are computed and analyzed by the feature selection algorithms. The divergence, histogram analysis, and discriminant analysis approaches are intercompared for their effectiveness in feature selection. The fuzzy expert system method is used not only to determine the effectiveness of each approach in classifying polar scenes, but also to further reduce the features into a more optimal set. For each selection method,features are ranked from best to worst, and the best half of the features are selected. Then, rules using these selected features are defined. The results of running the fuzzy expert system with these rules show that the divergence method produces the best set features, not only does it produce the highest classification accuracy, but also it has the lowest computation requirements. A reduction of the set of features produced by the divergence method using the fuzzy expert system results in an overall classification accuracy of over 95 %. However, this increase of accuracy has a high computation cost.

  11. Advanced border monitoring sensor system

    NASA Astrophysics Data System (ADS)

    Knobler, Ronald A.; Winston, Mark A.

    2008-04-01

    McQ has developed an advanced sensor system tailored for border monitoring that has been delivered as part of the SBInet program for the Department of Homeland Security (DHS). Technology developments that enhance a broad range of features are presented in this paper, which address the overall goal of the system to improving unattended ground sensor system capabilities for border monitoring applications. Specifically, this paper addresses a system definition, communications architecture, advanced signal processing to classify targets, and distributed sensor fusion processing.

  12. Advanced Composition

    ERIC Educational Resources Information Center

    Sarantos, R. L.

    1974-01-01

    This is an excerpt from a course for advanced students, designed to teach proficiency in English composition by providing activities specifically geared to the elimination of native language interference. (LG)

  13. LC-IMS-MS Feature Finder

    SciTech Connect

    2013-03-07

    LC-IMS-MS Feature Finder is a command line software application which searches for possible molecular ion signatures in multidimensional liquid chromatography, ion mobility spectrometry, and mass spectrometry data by clustering deisotoped peaks with similar monoisotopic mass values, charge states, elution times, and drift times. The software application includes an algorithm for detecting multiple conformations and co-eluting species in the ion mobility dimension. LC-IMS-MS Feature Finder is designed to create an output file with detected features that includes associated information about the detected features.

  14. LC-IMS-MS Feature Finder

    2013-03-07

    LC-IMS-MS Feature Finder is a command line software application which searches for possible molecular ion signatures in multidimensional liquid chromatography, ion mobility spectrometry, and mass spectrometry data by clustering deisotoped peaks with similar monoisotopic mass values, charge states, elution times, and drift times. The software application includes an algorithm for detecting multiple conformations and co-eluting species in the ion mobility dimension. LC-IMS-MS Feature Finder is designed to create an output file with detected features thatmore » includes associated information about the detected features.« less

  15. Defeating feature fatigue.

    PubMed

    Rust, Roland T; Thompson, Debora Viana; Hamilton, Rebecca W

    2006-02-01

    Consider a coffeemaker that offers 12 drink options, a car with more than 700 features on the dashboard, and a mouse pad that's also a clock, calculator, and FM radio. All are examples of "feature bloat", or "featuritis", the result of an almost irresistible temptation to load products with lots of bells and whistles. The problem is that the more features a product boasts, the harder it is to use. Manufacturers that increase a product's capability--the number of useful functions it can perform--at the expense of its usability are exposing their customers to feature fatigue. The authors have conducted three studies to gain a better understanding of how consumers weigh a product's capability relative to its usability. They found that even though consumers know that products with more features are harder to use, they initially choose high-feature models. They also pile on more features when given the chance to customize a product for their needs. Once consumers have actually worked with a product, however, usability starts to matter more to them than capability. For managers in consumer products companies, these findings present a dilemma: Should they maximize initial sales by designing high-feature models, which consumers consistently choose, or should they limit the number of features in order to enhance the lifetime value of their customers? The authors' analytical model guides companies toward a happy middle ground: maximizing the net present value of the typical customer's profit stream. The authors also advise companies to build simpler products, help consumers learn which products suit their needs, develop products that do one thing very well, and design market research in which consumers use actual products or prototypes.

  16. Feature Hepatitis: Hepatitis Can Strike Anyone

    MedlinePlus

    ... please turn Javascript on. From Hollywood's "Walk of Stars" to Main Street, USA, people from all walks ... that includes many well-known names: Legendary television star Larry Hagman was diagnosed with advanced hepatitis C ...

  17. Including Conflict in Creative Writing.

    ERIC Educational Resources Information Center

    Litvin, Martin

    Conflict is the basis of all stories and thus should appear in some form in the first sentence. There are three kinds of conflict: people vs. people; people vs. nature; and people vs. themselves. Conflict must be repeated in all the various elements of the story's structure, including the plot, which is the plan of action telling what happens to…

  18. Family Living, Including Sex Education.

    ERIC Educational Resources Information Center

    Forlano, George

    This volume describes and evaluates 21 selected New York City Board of Education Umbrella Programs for the 1974-1975 school year. The programs include: (1) the parent resource center, (2) the teacher self-help program, (3) the East Harlem pre-kindergarten center, (4) the Brooklyn College volunteer tutoring program, (5) the parent education for…

  19. [Clinical features of sleep disorders in older adults].

    PubMed

    Chiba, Shigeru; Tamura, Yoshiyuki

    2015-06-01

    There are three major neurophysiological mechanisms underlying the sleep-waking cycle: the sleep system, the waking system, and the system that determines sleep-waking timing. Sleep dlisorders of older adults seem to be caused by functional or organic changes in one or more of the three systems, and are roughly classified into two categories: (i) normal age-related, and (ii) pathological. The former includes decreased amplitude and advanced phase of circadian rhythms (body temperature, melatonin secretion, and sleep-waking), as well as reduced sleep duration, sleep fragmentation, and a decrease of slow-wave sleep in sleep architecture. Pathological sleep disorders include medical and psychiatric diseases (e.g., lifestyle-related diseases, dementia, delirium, and depression) and primary age-related sleep disorders (e.g., REM sleep behavior disorder and periodic limb move- ment disorders). This mini-review delineates the clinical features of sleep disorders in older adults.

  20. Features of the Java commodity grid kit.

    SciTech Connect

    von Laszewski, G.; Gawor, J.; Lane, P.; Rehn, N.; Russell, M.; Mathematics and Computer Science

    2002-11-01

    In this paper we report on the features of the Java Commodity Grid Kit (Java CoG Kit). The Java CoG Kit provides middleware for accessing Grid functionality from the Java framework. Java CoG Kit middleware is general enough to design a variety of advanced Grid applications with quite different user requirements. Access to the Grid is established via Globus Toolkit protocols, allowing the Java CoG Kit to also communicate with the services distributed as part of the C Globus Toolkit reference implementation. Thus, the Java CoG Kit provides Grid developers with the ability to utilize the Grid, as well as numerous additional libraries and frameworks developed by the Java community to enable network, Internet, enterprise and peer-to-peer computing. A variety of projects have successfully used the client libraries of the Java CoG Kit to access Grids driven by the C Globus Toolkit software. In this paper we also report on the efforts to develop serverside Java CoG Kit components. As part of this research we have implemented a prototype pure Java resource management system that enables one to run Grid jobs on platforms on which a Java virtual machine is supported, including Windows NT machines.

  1. New Features about Tau Function and Dysfunction

    PubMed Central

    Medina, Miguel; Hernández, Félix; Avila, Jesús

    2016-01-01

    Tau is a brain microtubule-associated protein that directly binds to a microtubule and dynamically regulates its structure and function. Under pathological conditions, tau self-assembles into filamentous structures that end up forming neurofibrillary tangles. Prominent tau neurofibrillary pathology is a common feature in a number of neurodegenerative disorders, collectively referred to as tauopathies, the most common of which is Alzheimer’s disease (AD). Beyond its classical role as a microtubule-associated protein, recent advances in our understanding of tau cellular functions have revealed novel insights into their important role during pathogenesis and provided potential novel therapeutic targets. Regulation of tau behavior and function under physiological and pathological conditions is mainly achieved through post-translational modifications, including phosphorylation, glycosylation, acetylation, and truncation, among others, indicating the complexity and variability of factors influencing regulation of tau toxicity, all of which have significant implications for the development of novel therapeutic approaches in various neurodegenerative disorders. A more comprehensive understanding of the molecular mechanisms regulating tau function and dysfunction will provide us with a better outline of tau cellular networking and, hopefully, offer new clues for designing more efficient approaches to tackle tauopathies in the near future. PMID:27104579

  2. Rosacea: clinical features and treatment.

    PubMed

    Lavers, Isabel

    2016-03-30

    Rosacea is a chronic inflammatory skin condition that predominantly affects the central face. It is characterised by a variable range of symptoms, including erythema, telangiectasia, papules, pustules and changes in skin texture. Rosacea may be transient, recurrent or persistent. Because it affects the most visible part of the body, the psychosocial effects of this condition can be significant. This article describes the features and management of the condition. PMID:27027198

  3. Flexible feature interface for multimedia sources

    DOEpatents

    Coffland, Douglas R.

    2009-06-09

    A flexible feature interface for multimedia sources system that includes a single interface for the addition of features and functions to multimedia sources and for accessing those features and functions from remote hosts. The interface utilizes the export statement: export "C" D11Export void FunctionName(int argc, char ** argv,char * result, SecureSession *ctrl) or the binary equivalent of the export statement.

  4. Composite, ordered material having sharp surface features

    DOEpatents

    D'Urso, Brian R.; Simpson, John T.

    2006-12-19

    A composite material having sharp surface features includes a recessive phase and a protrusive phase, the recessive phase having a higher susceptibility to a preselected etchant than the protrusive phase, the composite material having an etched surface wherein the protrusive phase protrudes from the surface to form a sharp surface feature. The sharp surface features can be coated to make the surface super-hydrophobic.

  5. Education Program on Fossil Resources Including Coal

    NASA Astrophysics Data System (ADS)

    Usami, Masahiro

    Fossil fuels including coal play a key role as crucial energies in contributing to economic development in Asia. On the other hand, its limited quantity and the environmental problems causing from its usage have become a serious global issue and a countermeasure to solve such problems is very much demanded. Along with the pursuit of sustainable development, environmentally-friendly use of highly efficient fossil resources should be therefore, accompanied. Kyushu-university‧s sophisticated research through long years of accumulated experience on the fossil resources and environmental sectors together with the advanced large-scale commercial and empirical equipments will enable us to foster cooperative research and provide internship program for the future researchers. Then, this program is executed as a consignment business from the Ministry of Economy, Trade and Industry from 2007 fiscal year to 2009 fiscal year. The lecture that uses the textbooks developed by this program is scheduled to be started a course in fiscal year 2010.

  6. All Students Need Advanced Mathematics. Math Works

    ERIC Educational Resources Information Center

    Achieve, Inc., 2013

    2013-01-01

    This fact sheet explains that to thrive in today's world, all students will need to graduate with very strong math skills. That can only mean one thing: advanced math courses are now essential math courses. Highlights of this paper include: (1) Advanced math equals college success; (2) Advanced math equals career opportunity; and (3) Advanced math…

  7. Feature selection in bioinformatics

    NASA Astrophysics Data System (ADS)

    Wang, Lipo

    2012-06-01

    In bioinformatics, there are often a large number of input features. For example, there are millions of single nucleotide polymorphisms (SNPs) that are genetic variations which determine the dierence between any two unrelated individuals. In microarrays, thousands of genes can be proled in each test. It is important to nd out which input features (e.g., SNPs or genes) are useful in classication of a certain group of people or diagnosis of a given disease. In this paper, we investigate some powerful feature selection techniques and apply them to problems in bioinformatics. We are able to identify a very small number of input features sucient for tasks at hand and we demonstrate this with some real-world data.

  8. Volcanic features of Io

    USGS Publications Warehouse

    Carr, M.H.; Masursky, H.; Strom, R.G.; Terrile, R.J.

    1979-01-01

    Volcanic activity is apparently higher on Io than on any other body in the Solar System. Its volcanic landforms can be compared with features on Earth to indicate the type of volcanism present on Io. ?? 1979 Nature Publishing Group.

  9. Lighted display devices for producing static or animated visual displays, including animated facial features

    DOEpatents

    Heilbron, Valerie J; Clem, Paul G; Cook, Adam Wade

    2014-02-11

    An illuminated display device with a base member with a plurality of cavities therein. Illumination devices illuminate the cavities and emit light through an opening of the cavities in a pattern, and a speaker can emit sounds in synchronization with the pattern. A panel with translucent portions can overly the base member and the cavities. An animated talking character can have an animated mouth cavity complex with multiple predetermined mouth lighting configurations simulative of human utterances. The cavities can be open, or optical waveguide material or positive members can be disposed therein. Reflective material can enhance internal reflectance and light emission.

  10. Cox-2 levels in canine mammary tumors, including inflammatory mammary carcinoma: clinicopathological features and prognostic significance.

    PubMed

    Queiroga, Felisbina Luisa; Perez-Alenza, Maria Dolores; Silvan, Gema; Peña, Laura; Lopes, Carlos; Illera, Juan Carlos

    2005-01-01

    Cyclo-oxygenase (Cox-2) plays an important role in mammary carcinogenesis, nevertheless, its role in canine mammary tumors, and particularly in inflammatory mammary carcinoma (IMC), is unknown. Tumor Cox-2 levels were analyzed by enzyme immunoassay, in post-surgical tumor homogenates of 129 mammary tumors (62 dysplasias and benign tumors, 57 malignant non-IMC and 10 IMC) from 57 female dogs. The highest Cox-2 values were detected in the IMC group. In non-IMC malignant tumors, high values of Cox-2 were related to skin ulceration (p < 0.001) and tumor size (p < 0.001). The follow-up study revealed that high Cox-2 levels were related with recurrence (p = 0.002), metastases (p < 0.001), disease-free survival (p < 0.001) and overall survival (p < 0.001). This study demonstrates an association between intra-tumor Cox-2 levels and poor prognosis. The high levels found in IMC cases could indicate a special role of Cox-2 in the inflammatory phenotype and open the possibility of additional new therapeutic approaches in this special type of mammary cancer in humans and dogs.

  11. Feature-oriented regional modeling and simulations (FORMS) for the western South Atlantic: Southeastern Brazil region

    NASA Astrophysics Data System (ADS)

    Calado, L.; Gangopadhyay, A.; da Silveira, I. C. A.

    The multi-scale synoptic circulation system in the southeastern Brazil (SEBRA) region is presented using a feature-oriented approach. Prevalent synoptic circulation structures, or "features," are identified from previous observational studies. These features include the southward-flowing Brazil Current (BC), the eddies off Cabo São Tomé (CST - 22°S) and off Cabo Frio (CF - 23°S), and the upwelling region off CF and CST. Their synoptic water-mass ( T- S) structures are characterized and parameterized to develop temperature-salinity ( T- S) feature models. Following [Gangopadhyay, A., Robinson, A.R., Haley, P.J., Leslie, W.J., Lozano, C.J., Bisagni, J., Yu, Z., 2003. Feature-oriented regional modeling and simulation (forms) in the gulf of maine and georges bank. Cont. Shelf Res. 23 (3-4), 317-353] methodology, a synoptic initialization scheme for feature-oriented regional modeling and simulation (FORMS) of the circulation in this region is then developed. First, the temperature and salinity feature-model profiles are placed on a regional circulation template and objectively analyzed with available background climatology in the deep region. These initialization fields are then used for dynamical simulations via the Princeton Ocean Model (POM). A few first applications of this methodology are presented in this paper. These include the BC meandering, the BC-eddy interaction and the meander-eddy-upwelling system (MEUS) simulations. Preliminary validation results include realistic wave-growth and eddy formation and sustained upwelling. Our future plan includes the application of these feature models with satellite, in-situ data and advanced data-assimilation schemes for nowcasting and forecasting the SEBRA region.

  12. The ACTS Flight System - Cost-Effective Advanced Communications Technology. [Advanced Communication Technology Satellite

    NASA Technical Reports Server (NTRS)

    Holmes, W. M., Jr.; Beck, G. A.

    1984-01-01

    The multibeam communications package (MCP) for the Advanced Communications Technology Satellite (ACTS) to be STS-launched by NASA in 1988 for experimental demonstration of satellite-switched TDMA (at 220 Mbit/sec) and baseband-processor signal routing (at 110 or 27.5 Mbit/sec) is characterized. The developmental history of the ACTS, the program definition, and the spacecraft-bus and MCP parameters are reviewed and illustrated with drawings, block diagrams, and maps of the coverage plan. Advanced features of the MPC include 4.5-dB-noise-figure 30-GHz FET amplifiers and 20-GHz TWTA transmitters which provide either 40-W or 8-W RF output, depending on rain conditions. The technologies being tested in ACTS can give frequency-reuse factors as high as 20, thus greatly expanding the orbit/spectrum resources available for U.S. communications use.

  13. Advanced CO2 removal process control and monitor instrumentation development

    NASA Technical Reports Server (NTRS)

    Heppner, D. B.; Dalhausen, M. J.; Klimes, R.

    1982-01-01

    A progam to evaluate, design and demonstrate major advances in control and monitor instrumentation was undertaken. A carbon dioxide removal process, one whose maturity level makes it a prime candidate for early flight demonstration was investigated. The instrumentation design incorporates features which are compatible with anticipated flight requirements. Current electronics technology and projected advances are included. In addition, the program established commonality of components for all advanced life support subsystems. It was concluded from the studies and design activities conducted under this program that the next generation of instrumentation will be greatly smaller than the prior one. Not only physical size but weight, power and heat rejection requirements were reduced in the range of 80 to 85% from the former level of research and development instrumentation. Using a microprocessor based computer, a standard computer bus structure and nonvolatile memory, improved fabrication techniques and aerospace packaging this instrumentation will greatly enhance overall reliability and total system availability.

  14. Progress in systemic therapy of advanced hepatocellular carcinoma

    PubMed Central

    Gong, Xin-Lei; Qin, Shu-Kui

    2016-01-01

    Primary liver cancer, mainly consisting of hepatocellular carcinoma (HCC), is one of common malignancies worldwide, and prevalent among the Chinese population. A diagnosis of early stage HCC has proven to be very difficult because of its insidious feature in onset and development. At the time of diagnosis, most HCC cases are locally advanced and/or distant metastatic, which results in difficulty to be treated and poor prognosis. For advanced HCC, systemic therapy is frequently adopted as an important palliative method. In recent years, clinical studies and observations have often reported about systemic anti-cancer therapy of advanced HCC, including molecular target therapy, systemic chemotherapy and immunotherapy. In this article, we review these treatment modalities to provide a reference for clinicians. PMID:27547002

  15. Advances of vibrational spectroscopic methods in phytomics and bioanalysis.

    PubMed

    Huck, Christian W

    2014-01-01

    During the last couple of years great advances in vibrational spectroscopy including near-infrared (NIR), mid-infrared (MIR), attenuated total reflection (ATR) and imaging and also mapping techniques could be achieved. On the other hand spectral treatment features have improved dramatically allowing filtering out relevant information from spectral data much more efficiently and providing new insights into the biochemical composition. These advances offer new possible quality control strategies in phytomics and enable to get deeper insights into biochemical background in terms of medicinal relevant questions. It is the aim of the present article pointing out the technical and methodological advancements in the NIR and MIR field and to demonstrate the individual methods efficiency by discussing distinct selected applications.

  16. Materials and light thermal structures research for advanced space exploration

    NASA Technical Reports Server (NTRS)

    Thornton, Earl A.; Starke, Edgar A., Jr.; Herakovich, Carl T.

    1991-01-01

    The Light Thermal Structures Center at the University of Virginia sponsors educational and research programs focused on the development of reliable, lightweight structures to function in hostile thermal environments. Technology advances in materials and design methodology for light thermal structures will contribute to improved space vehicle design concepts with attendant weight savings. This paper highlights current research activities in three areas relevant to space exploration: low density, high temperature aluminum alloys, composite materials, and structures with thermal gradients. Advances in the development of new aluminum-lithium alloys and mechanically alloyed aluminum alloys are described. Material properties and design features of advanced composites are highlighted. Research studies in thermal structures with temperature gradients include inelastic panel buckling and thermally induced unstable oscillations. Current and future research is focused on the integration of new materials with applications to structural components with thermal gradients.

  17. Neoclassical Transport Including Collisional Nonlinearity

    SciTech Connect

    Candy, J.; Belli, E. A.

    2011-06-10

    In the standard {delta}f theory of neoclassical transport, the zeroth-order (Maxwellian) solution is obtained analytically via the solution of a nonlinear equation. The first-order correction {delta}f is subsequently computed as the solution of a linear, inhomogeneous equation that includes the linearized Fokker-Planck collision operator. This equation admits analytic solutions only in extreme asymptotic limits (banana, plateau, Pfirsch-Schlueter), and so must be solved numerically for realistic plasma parameters. Recently, numerical codes have appeared which attempt to compute the total distribution f more accurately than in the standard ordering by retaining some nonlinear terms related to finite-orbit width, while simultaneously reusing some form of the linearized collision operator. In this work we show that higher-order corrections to the distribution function may be unphysical if collisional nonlinearities are ignored.

  18. Features of Published Analyses of Canonical Results.

    ERIC Educational Resources Information Center

    Humphries-Wadsworth, Terresa M.

    D. Wood and J. Erskine (1976) and B. Thompson (1989) provided bibliographies of roughly 130 applications of canonical correlation analysis, but the features of such reports have not been widely studied. This report examines the features of recent canonical reports, including substantive inquiries, but also measurement applications examining…

  19. Protein sequence classification using feature hashing.

    PubMed

    Caragea, Cornelia; Silvescu, Adrian; Mitra, Prasenjit

    2012-06-21

    Recent advances in next-generation sequencing technologies have resulted in an exponential increase in the rate at which protein sequence data are being acquired. The k-gram feature representation, commonly used for protein sequence classification, usually results in prohibitively high dimensional input spaces, for large values of k. Applying data mining algorithms to these input spaces may be intractable due to the large number of dimensions. Hence, using dimensionality reduction techniques can be crucial for the performance and the complexity of the learning algorithms. In this paper, we study the applicability of feature hashing to protein sequence classification, where the original high-dimensional space is "reduced" by hashing the features into a low-dimensional space, using a hash function, i.e., by mapping features into hash keys, where multiple features can be mapped (at random) to the same hash key, and "aggregating" their counts. We compare feature hashing with the "bag of k-grams" approach. Our results show that feature hashing is an effective approach to reducing dimensionality on protein sequence classification tasks.

  20. Advanced steel reheat furnace

    SciTech Connect

    Moyeda, D.; Sheldon, M.; Koppang, R.; Lanyi, M.; Li, X.; Eleazer, B.

    1997-10-01

    Energy and Environmental Research Corp. (EER) under a contract from the Department of Energy is pursuing the development and demonstration of an Advanced Steel Reheating Furnace. This paper reports the results of Phase 1, Research, which has evaluated an advanced furnace concept incorporating two proven and commercialized technologies previously applied to other high temperature combustion applications: EER`s gas reburn technology (GR) for post combustion NOx control; and Air Product`s oxy-fuel enrichment air (OEA) for improved flame heat transfer in the heating zones of the furnace. The combined technologies feature greater production throughput with associated furnace efficiency improvements; lowered NOx emissions; and better control over the furnace atmosphere, whether oxidizing or reducing, leading to better control over surface finish.

  1. An airline study of advanced technology requirements for advanced high speed commercial transport engines. 1: Engine design study assessment

    NASA Technical Reports Server (NTRS)

    Sallee, G. P.

    1973-01-01

    The advanced technology requirements for an advanced high speed commercial tranport engine are presented. The results of the phase 1 study effort cover the following areas: (1) statement of an airline's major objectives for future transport engines, (2) airline's method of evaluating engine proposals, (3) description of an optimum engine for a long range subsonic commercial transport including installation and critical design features, (4) discussion of engine performance problems and experience with performance degradation, (5) trends in engine and pod prices with increasing technology and objectives for the future, (6) discussion of the research objectives for composites, reversers, advanced components, engine control systems, and devices to reduce the impact of engine stall, and (7) discussion of the airline objectives for noise and pollution reduction.

  2. Technological Advancements

    ERIC Educational Resources Information Center

    Kennedy, Mike

    2010-01-01

    The influx of technology has brought significant improvements to school facilities. Many of those advancements can be found in classrooms, but when students head down the hall to use the washrooms, they are likely to find a host of technological innovations that have improved conditions in that part of the building. This article describes modern…

  3. Advanced Coats' disease.

    PubMed Central

    Haik, B G

    1991-01-01

    Advanced Coats' disease and retinoblastoma can both present with the triad of a retinal detachment, the appearance of a subretinal mass, and dilated retinal vessels. Thus, even the most experienced observer may not be able to differentiate these entities on ophthalmoscopic findings alone. Coats' disease is the most common reason for which eyes are enucleated with the misdiagnosis of retinoblastoma. Ultrasonography is the auxiliary diagnostic test most easily incorporated into the clinical examination, and can be utilized repeatedly without biologic tissue hazard. Ultrasonically identifiable features allowing differentiation between Coats' disease and retinoblastoma include the topography and character of retinal detachment and presence or absence of subretinal calcifications. Ultrasonography is of lesser use in poorly calcified retinoblastoma and in detecting optic nerve or extraocular extension in heavily calcified retinoblastoma. CT is perhaps the single most valuable test because of its ability to: (a) delineate intraocular morphology, (b) quantify subretinal densities, (c) identify vascularities within the subretinal space through the use of contrast enhancement, and (d) detected associated orbital or intracranial abnormalities. Optimal computed tomographic studies, however, require multiple thin slices both before and after contrast introduction and expose the child to low levels of radiation if studies are repeated periodically. MR imaging is valuable for its multiplanar imaging capabilities, its superior contrast resolution, and its ability to provide insights into the biochemical structure and composition of tissues. It is limited in its ability to detect calcium, which is the mainstay of ultrasonic and CT differentiation. Aqueous LDH and isoenzyme levels were not valuable in distinguishing between Coats' disease and retinoblastoma. The value of aqueous NSE levels in the differentiation of advanced Coats' disease and exophytic retinoblastoma deserves

  4. Including Magnetostriction in Micromagnetic Models

    NASA Astrophysics Data System (ADS)

    Conbhuí, Pádraig Ó.; Williams, Wyn; Fabian, Karl; Nagy, Lesleis

    2016-04-01

    The magnetic anomalies that identify crustal spreading are predominantly recorded by basalts formed at the mid-ocean ridges, whose magnetic signals are dominated by iron-titanium-oxides (Fe3-xTixO4), so called "titanomagnetites", of which the Fe2.4Ti0.6O4 (TM60) phase is the most common. With sufficient quantities of titanium present, these minerals exhibit strong magnetostriction. To date, models of these grains in the pseudo-single domain (PSD) range have failed to accurately account for this effect. In particular, a popular analytic treatment provided by Kittel (1949) for describing the magnetostrictive energy as an effective increase of the anisotropy constant can produce unphysical strains for non-uniform magnetizations. I will present a rigorous approach based on work by Brown (1966) and by Kroner (1958) for including magnetostriction in micromagnetic codes which is suitable for modelling hysteresis loops and finding remanent states in the PSD regime. Preliminary results suggest the more rigorously defined micromagnetic models exhibit higher coercivities and extended single domain ranges when compared to more simplistic approaches.

  5. Choosing efficient feature sets for video classification

    NASA Astrophysics Data System (ADS)

    Fischer, Stephan; Steinmetz, Ralf

    1998-12-01

    In this paper, we address the problem of choosing appropriate features to describe the content of still pictures or video sequences, including audio. As the computational analysis of these features is often time- consuming, it is useful to identify a minimal set allowing for an automatic classification of some class or genre. Further, it can be shown that deleting the coherence of the features characterizing some class, is not suitable to guarantee an optimal classification result. The central question of the paper is thus, which features should be selected, and how they should be weighted to optimize a classification problem.

  6. Advanced Gas Turbine (AGT)

    NASA Technical Reports Server (NTRS)

    1983-01-01

    The development and progress of the Advanced Gas Turbine engine program is examined. An analysis of the role of ceramics in the design and major engine components is included. Projected fuel economy, emissions and performance standards, and versatility in fuel use are also discussed.

  7. Advanced Civilian Aeronautical Concepts

    NASA Technical Reports Server (NTRS)

    Bushnell, Dennis M.

    1996-01-01

    Paper discusses alternatives to currently deployed systems which could provide revolutionary improvements in metrics applicable to civilian aeronautics. Specific missions addressed include subsonic transports, supersonic transports and personal aircraft. These alternative systems and concepts are enabled by recent and envisaged advancements in electronics, communications, computing and Designer Fluid Mechanics in conjunction with a design approach employing extensive synergistic interactions between propulsion, aerodynamics and structures.

  8. Recent Advances in Radical SAM Enzymology: New Structures and Mechanisms

    PubMed Central

    2015-01-01

    The radical S-adenosylmethionine (SAM) superfamily of enzymes catalyzes an amazingly diverse variety of reactions ranging from simple hydrogen abstraction to complicated multistep rearrangements and insertions. The reactions they catalyze are important for a broad range of biological functions, including cofactor and natural product biosynthesis, DNA repair, and tRNA modification. Generally conserved features of the radical SAM superfamily include a CX3CX2C motif that binds an [Fe4S4] cluster essential for the reductive cleavage of SAM. Here, we review recent advances in our understanding of the structure and mechanisms of these enzymes that, in some cases, have overturned widely accepted mechanisms. PMID:25009947

  9. Recent advances in understanding of chronic kidney disease

    PubMed Central

    Yamaguchi, Junna; Tanaka, Tetsuhiro; Nangaku, Masaomi

    2015-01-01

    Chronic kidney disease (CKD) is defined as any condition that causes reduced kidney function over a period of time. Fibrosis, tubular atrophy and interstitial inflammation are the hallmark of pathological features in CKD. Regardless of initial insult, CKD has some common pathways leading CKD to end-stage kidney disease, including hypoxia in the tubulointerstitium and proteinuria. Recent advances in genome editing technologies and stem cell research give great insights to understand the pathogenesis of CKD, including identifications of the origins of renal myofibroblasts and tubular epithelial cells upon injury. Environmental factors such as hypoxia, oxidative stress, and epigenetic factors in relation to CKD are also discussed. PMID:26937272

  10. Special Issue featuring invited articles arising from UK Semiconductors 2012

    NASA Astrophysics Data System (ADS)

    Clarke, Edmund; Wada, Osamu

    2013-07-01

    Semiconductor research has formed the basis of many technological advances over the past 50 years, and the field is still highly active, as new material systems and device concepts are developed to address new applications or operating conditions. In addition to the development of traditional semiconductor devices, the wealth of experience with these materials also allows their use as an ideal environment for testing new physics, leading to new classes of devices exploiting quantum mechanical effects that can also benefit from the advantages of existing semiconductor technology in scalability, compactness and ease of mass production. This special issue features papers arising from the UK Semiconductors 2012 Conference, held at the University of Sheffield. The annual conference covers all aspects of semiconductor research, from crystal growth, through investigations of the physics of semiconductor structures to realization of semiconductor devices and their application in emerging technologies. The 2012 conference featured over 150 presentations, including plenary sessions on interband cascade lasers for the 3-6 µm spectral band, efficient single photon sources based on InAs quantum dots embedded in GaAs photonic nanowires, nitride-based quantum dot visible lasers and single photon sources, and engineering of organic light-emitting diodes. The seven papers collected here highlight current research advances, taken from across the scope of the conference. The papers feature growth of novel nitride-antimonide material systems for mid-infrared sources and detectors, use of semiconductor nanostructures for charge-based memory and visible lasers, optimization of device structures either to reduce losses in solar cells or achieve low noise amplification in transistors, design considerations for surface-emitting lasers incorporating photonic crystals and an assessment of laser power convertors for power transfer. The editors of this special issue and the conference

  11. Neurologic and developmental features of the Smith-Magenis syndrome (del 17p11.2).

    PubMed

    Gropman, Andrea L; Duncan, Wallace C; Smith, Ann C M

    2006-05-01

    The Smith-Magenis syndrome is a rare, complex multisystemic disorder featuring, mental retardation and multiple congenital anomalies caused by a heterozygous interstitial deletion of chromosome 17p11.2. The phenotype of Smith-Magenis syndrome is characterized by a distinct pattern of features including infantile hypotonia, generalized complacency and lethargy in infancy, minor skeletal (brachycephaly, brachydactyly) and craniofacial features, ocular abnormalities, middle ear and laryngeal abnormalities including hoarse voice, as well as marked early expressive speech and language delays, psychomotor and growth retardation, and a 24-hour sleep disturbance. A striking neurobehavioral pattern of stereotypies, hyperactivity, polyembolokoilamania, onychotillomania, maladaptive and self-injurious and aggressive behavior is observed with increasing age. The diagnosis of Smith-Magenis syndrome is based upon the clinical recognition of a constellation of physical, developmental, and behavioral features in combination with a sleep disorder characterized by inverted circadian rhythm of melatonin secretion. Many of the features of Smith-Magenis syndrome are subtle in infancy and early childhood, and become more recognizable with advancing age. Infants are described as looking "cherubic" with a Down syndrome-like appearance, whereas with age the facial appearance is that of relative prognathism. Early diagnosis requires awareness of the often subtle clinical and neurobehavioral phenotype of the infant period. Speech delay with or without hearing loss is common. Most children are diagnosed in mid-childhood when the features of the disorder are most recognizable and striking. While improvements in cytogenetic analysis help to bring cases to clinical recognition at an earlier age, this review seeks to increase clinical awareness about Smith-Magenis syndrome by presenting the salient features observed at different ages including descriptions of the neurologic and behavioral

  12. Substation fire protection features

    SciTech Connect

    Hausheer, T.G.

    1995-10-01

    This paper describes Commonwealth Edison`s (ComEd) approach to substation fire protection. Substation fires can have a major operational, financial, as well as political impact on a utility. The overall Company philosophy encompasses both active and passive fire protection features to provide prompt detection, notification, and confinement of fire and its by-products. Conservatively designed smoke detection systems and floor and wall penetration seals form the backbone of this strategy. The Company has implemented a program to install these features in new and existing substations. Thus far these measures have been successful in mitigating the consequences of substation fires.

  13. Escalator design features evaluation

    NASA Technical Reports Server (NTRS)

    Zimmerman, W. F.; Deshpande, G. K.

    1982-01-01

    Escalators are available with design features such as dual speed (90 and 120 fpm), mat operation and flat steps. These design features were evaluated based on the impact of each on capital and operating costs, traffic flow, and safety. A human factors engineering model was developed to analyze the need for flat steps at various speeds. Mat operation of escalators was found to be cost effective in terms of energy savings. Dual speed operation of escalators with the higher speed used during peak hours allows for efficient operation. A minimum number of flat steps required as a function of escalator speed was developed to ensure safety for the elderly.

  14. Advanced technologies for rocket single-stage-to-orbit vehicles

    NASA Astrophysics Data System (ADS)

    Wilhite, Alan W.; Bush, Lance B.; Cruz, Christopher I.; Lepsch, Roger A.; Morris, W. Douglas; Stanley, Douglas O.; Wurster, Kathryn E.

    1991-01-01

    A single-stage-to-orbit vertical takeoff/horizontal landing rocket vehicle was studied to determine the benefits of advanced technology. Advanced technologies that were included in the study were variable mixture ratio oxygen/hydrogen rocket engines and materials, structures, and subsystem technologies currently being developed in the National Aero-Space Plane Program. The application of advanced technology results in an 85 percent reduction in vehicle dry weight. With advanced materials, an external thermal protection system, like the Space Shuttle tiles, was not required. Compared to an all-airbreathing horizontal takeoff/horizontal landing vehicle using the same advanced technologies and mission requirements, the rocket vehicle is lighter in dry weight and has fewer subsystems. To increase reliability and safety, operational features were included in the rocket vehicle-robust subsystems, 5 percent additional margin, no slush hydrogen, fail-operational with an engine out, and a crew escape module. The resulting vehicle grew in dry weight and was still lower in dry weight than the airbreathing vehicle.

  15. Pores and ridges: high-resolution fingerprint matching using level 3 features.

    PubMed

    Jain, Anil K; Chen, Yi; Demirkus, Meltem

    2007-01-01

    Fingerprint friction ridge details are generally described in a hierarchical order at three different levels, namely, Level 1 (pattern), Level 2 (minutia points), and Level 3 (pores and ridge contours). Although latent print examiners frequently take advantage of Level 3 features to assist in identification, Automated Fingerprint Identification Systems (AFIS) currently rely only on Level 1 and Level 2 features. In fact, the Federal Bureau of Investigation's (FBI) standard of fingerprint resolution for AFIS is 500 pixels per inch (ppi), which is inadequate for capturing Level 3 features, such as pores. With the advances in fingerprint sensing technology, many sensors are now equipped with dual resolution (500 ppi/1,000 ppi) scanning capability. However, increasing the scan resolution alone does not necessarily provide any performance improvement in fingerprint matching, unless an extended feature set is utilized. As a result, a systematic study to determine how much performance gain one can achieve by introducing Level 3 features in AFIS is highly desired. We propose a hierarchical matching system that utilizes features at all the three levels extracted from 1,000 ppi fingerprint scans. Level 3 features, including pores and ridge contours, are automatically extracted using Gabor filters and wavelet transform and are locally matched using the Iterative Closest Point (ICP) algorithm. Our experiments show that Level 3 features carry significant discriminatory information. There is a relative reduction of 20 percent in the equal error rate (EER) of the matching system when Level 3 features are employed in combination with Level 1 and 2 features. This significant performance gain is consistently observed across various quality fingerprint images.

  16. Pores and ridges: high-resolution fingerprint matching using level 3 features.

    PubMed

    Jain, Anil K; Chen, Yi; Demirkus, Meltem

    2007-01-01

    Fingerprint friction ridge details are generally described in a hierarchical order at three different levels, namely, Level 1 (pattern), Level 2 (minutia points), and Level 3 (pores and ridge contours). Although latent print examiners frequently take advantage of Level 3 features to assist in identification, Automated Fingerprint Identification Systems (AFIS) currently rely only on Level 1 and Level 2 features. In fact, the Federal Bureau of Investigation's (FBI) standard of fingerprint resolution for AFIS is 500 pixels per inch (ppi), which is inadequate for capturing Level 3 features, such as pores. With the advances in fingerprint sensing technology, many sensors are now equipped with dual resolution (500 ppi/1,000 ppi) scanning capability. However, increasing the scan resolution alone does not necessarily provide any performance improvement in fingerprint matching, unless an extended feature set is utilized. As a result, a systematic study to determine how much performance gain one can achieve by introducing Level 3 features in AFIS is highly desired. We propose a hierarchical matching system that utilizes features at all the three levels extracted from 1,000 ppi fingerprint scans. Level 3 features, including pores and ridge contours, are automatically extracted using Gabor filters and wavelet transform and are locally matched using the Iterative Closest Point (ICP) algorithm. Our experiments show that Level 3 features carry significant discriminatory information. There is a relative reduction of 20 percent in the equal error rate (EER) of the matching system when Level 3 features are employed in combination with Level 1 and 2 features. This significant performance gain is consistently observed across various quality fingerprint images. PMID:17108380

  17. Satellite observations of mesoscale features in lower Cook Inlet and Shelikof Strait, Gulf of Alaska

    NASA Technical Reports Server (NTRS)

    Schumacher, James D.; Barber, Willard E.; Holt, Benjamin; Liu, Antony K.

    1991-01-01

    The Seasat satellite launched in Summer 1978 carried a synthetic aperture radar (SAR). Although Seasat failed after 105 days in orbit, it provided observations that demonstrate the potential to examine and monitor upper oceanic processes. Seasat made five passes over lower Cook Inlet and Shelikof Strait, Alaska, during Summer 1978. SAR images from the passes show oceanographic features, including a meander in a front, a pair of mesoscale eddies, and internal waves. These features are compared with contemporary and representative images from a satellite-borne Advanced Very High Resolution Radiometer (AVHRR) and Coastal Zone Color Scanner (CZCS), with water property data, and with current observations from moored instruments. The results indicate that SAR data can be used to monitor mesoscale oceanographic features.

  18. Advanced concepts for acceleration

    SciTech Connect

    Keefe, D.

    1986-07-01

    Selected examples of advanced accelerator concepts are reviewed. Such plasma accelerators as plasma beat wave accelerator, plasma wake field accelerator, and plasma grating accelerator are discussed particularly as examples of concepts for accelerating relativistic electrons or positrons. Also covered are the pulsed electron-beam, pulsed laser accelerator, inverse Cherenkov accelerator, inverse free-electron laser, switched radial-line accelerators, and two-beam accelerator. Advanced concepts for ion acceleration discussed include the electron ring accelerator, excitation of waves on intense electron beams, and two-wave combinations. (LEW)

  19. Advanced subsonic transport propulsion

    NASA Technical Reports Server (NTRS)

    Nored, D. L.; Ciepluch, C. C.; Chamberlain, R.; Meleason, E. T.; Kraft, G. A.

    1981-01-01

    A brief review of the current NASA Energy Efficient Engine (E(3)) Project is presented. Included in this review are the factors that influenced the design of these turbofan engines and the advanced technology incorporated in them to reduce fuel consumption and improve environmental characteristics. In addition, factors such as the continuing spiral in fuel cost, that could influence future aircraft propulsion systems beyond those represented by the E(3) engines, are also discussed. Advanced technologies that will address these influencing factors and provide viable future propulsion systems are described. The potential importance of other propulsion system types, such as geared fans and turboshaft engines, is presented.

  20. Searchable solar feature catalogues

    NASA Astrophysics Data System (ADS)

    Zharkova, V. V.; Aboudarham, J.; Zharkov, S.; Ipson, S. S.; Benkhalil, A. K.; Fuller, N.

    The searchable Solar Feature Catalogues (SFCs) are developed from digitized solar images using automated pattern recognition techniques. The techniques were applied for the detection of sunspots, active regions, filaments and line-of-sight magnetic neutral lines in automatically standardized full disk solar images in Ca II K1, Ca II K3 and Ha lines taken at the Paris-Meudon Observatory and white light images and magnetograms from SOHO/MDI. The results of the automated recognition were verified with manual synoptic maps and available statistical data that revealed good detection accuracy. Based on the recognized parameters, a structured database of Solar Feature Catalogues was built on a MySQL server for every feature and published with various pre-designed search pages on the Bradford University web site http://www.cyber.brad.ac.uk/egso/SFC/. The SFCs with nine year coverage (1996-2004) is to be used for deeper investigation of the feature classification and solar activity forecast.

  1. Assistive Technologies, Feature Issue.

    ERIC Educational Resources Information Center

    Wobschall, Rachel, Ed.; Lakin, Charlie, Ed.

    1995-01-01

    This feature issue of a newsletter on community integration of individuals with developmental disabilities considers the role of assistive technologies. It describes efforts to utilize consumer direction, public policy, creativity, energy, and professional know-how in the pursuit of technology-based opportunities to enhance community inclusion,…

  2. Main features of meiosis

    SciTech Connect

    1993-12-31

    Chapter 17, outlines the main features of meiosis, beginning with its significance and proceeding through the meiotic stages. Meiosis is the most important modification of mitosis because it is the reduction division that gives rise to the haploid generation in the life cycle. 17 refs., 6 figs.

  3. Advanced Combustion

    SciTech Connect

    Holcomb, Gordon R.

    2013-03-11

    The activity reported in this presentation is to provide the mechanical and physical property information needed to allow rational design, development and/or choice of alloys, manufacturing approaches, and environmental exposure and component life models to enable oxy-fuel combustion boilers to operate at Ultra-Supercritical (up to 650{degrees}C & between 22-30 MPa) and/or Advanced Ultra-Supercritical conditions (760{degrees}C & 35 MPa).

  4. Advanced Nanoemulsions

    NASA Astrophysics Data System (ADS)

    Fryd, Michael M.; Mason, Thomas G.

    2012-05-01

    Recent advances in the growing field of nanoemulsions are opening up new applications in many areas such as pharmaceuticals, foods, and cosmetics. Moreover, highly controlled nanoemulsions can also serve as excellent model systems for investigating basic scientific questions about soft matter. Here, we highlight some of the most recent developments in nanoemulsions, focusing on methods of formation, surface modification, material properties, and characterization. These developments provide insight into the substantial advantages that nanoemulsions can offer over their microscale emulsion counterparts.

  5. MERCURY CONTROL WITH ADVANCED HYBRID PARTICULATE COLLECTOR

    SciTech Connect

    Ye Zhuang; Stanley J. Miller

    2005-05-01

    This project was awarded under U.S. Department of Energy (DOE) National Energy Technology Laboratory (NETL) Program Solicitation DE-PS26-00NT40769 and specifically addressed Technical Topical Area 4-Testing Novel and Less Mature Control Technologies on Actual Flue Gas at the Pilot Scale. The project team included the Energy & Environmental Research Center (EERC) as the main contractor; W.L. Gore & Associates, Inc., as a technical and financial partner; and the Big Stone Power Plant operated by Otter Tail Power Company, host for the field-testing portion of the research. Since 1995, DOE has supported development of a new concept in particulate control called the advanced hybrid particulate collector (AHPC). The AHPC has been licensed to W.L. Gore & Associates, Inc., and has been marketed as the Advanced Hybrid{trademark} filter by Gore. The Advanced Hybrid{trademark} filter combines the best features of electrostatic precipitators (ESPs) and baghouses in a unique configuration, providing major synergism between the two collection methods, both in the particulate collection step and in the transfer of dust to the hopper. The Advanced Hybrid{trademark} filter provides ultrahigh collection efficiency, overcoming the problem of excessive fine-particle emissions with conventional ESPs, and it solves the problem of reentrainment and re-collection of dust in conventional baghouses. The Advanced Hybrid{trademark} filter also appears to have unique advantages for mercury control over baghouses or ESPs as an excellent gas--solid contactor. The objective of the project was to demonstrate 90% total mercury control in the Advanced Hybrid{trademark} filter at a lower cost than current mercury control estimates. The approach included bench-scale batch tests, larger-scale pilot testing with real flue gas on a coal-fired combustion system, and field demonstration at the 2.5-MW (9000-acfm) scale at a utility power plant to prove scale-up and demonstrate longer-term mercury control

  6. Features of MCNP6 Relevant to Medical Radiation Physics

    SciTech Connect

    Hughes, H. Grady III; Goorley, John T.

    2012-08-29

    MCNP (Monte Carlo N-Particle) is a general-purpose Monte Carlo code for simulating the transport of neutrons, photons, electrons, positrons, and more recently other fundamental particles and heavy ions. Over many years MCNP has found a wide range of applications in many different fields, including medical radiation physics. In this presentation we will describe and illustrate a number of significant recently-developed features in the current version of the code, MCNP6, having particular utility for medical physics. Among these are major extensions of the ability to simulate large, complex geometries, improvement in memory requirements and speed for large lattices, introduction of mesh-based isotopic reaction tallies, advances in radiography simulation, expanded variance-reduction capabilities, especially for pulse-height tallies, and a large number of enhancements in photon/electron transport.

  7. Advanced control technology and its potential for future transport aircraft

    NASA Technical Reports Server (NTRS)

    1976-01-01

    The topics covered include fly by wire, digital control, control configured vehicles, applications to advanced flight vehicles, advanced propulsion control systems, and active control technology for transport aircraft.

  8. Advanced electronics for the CTF MEG system.

    PubMed

    McCubbin, J; Vrba, J; Spear, P; McKenzie, D; Willis, R; Loewen, R; Robinson, S E; Fife, A A

    2004-11-30

    Development of the CTF MEG system has been advanced with the introduction of a computer processing cluster between the data acquisition electronics and the host computer. The advent of fast processors, memory, and network interfaces has made this innovation feasible for large data streams at high sampling rates. We have implemented tasks including anti-alias filter, sample rate decimation, higher gradient balancing, crosstalk correction, and optional filters with a cluster consisting of 4 dual Intel Xeon processors operating on up to 275 channel MEG systems at 12 kHz sample rate. The architecture is expandable with additional processors to implement advanced processing tasks which may include e.g., continuous head localization/motion correction, optional display filters, coherence calculations, or real time synthetic channels (via beamformer). We also describe an electronics configuration upgrade to provide operator console access to the peripheral interface features such as analog signal and trigger I/O. This allows remote location of the acoustically noisy electronics cabinet and fitting of the cabinet with doors for improved EMI shielding. Finally, we present the latest performance results available for the CTF 275 channel MEG system including an unshielded SEF (median nerve electrical stimulation) measurement enhanced by application of an adaptive beamformer technique (SAM) which allows recognition of the nominal 20-ms response in the unaveraged signal.

  9. Advanced electronics for the CTF MEG system.

    PubMed

    McCubbin, J; Vrba, J; Spear, P; McKenzie, D; Willis, R; Loewen, R; Robinson, S E; Fife, A A

    2004-01-01

    Development of the CTF MEG system has been advanced with the introduction of a computer processing cluster between the data acquisition electronics and the host computer. The advent of fast processors, memory, and network interfaces has made this innovation feasible for large data streams at high sampling rates. We have implemented tasks including anti-alias filter, sample rate decimation, higher gradient balancing, crosstalk correction, and optional filters with a cluster consisting of 4 dual Intel Xeon processors operating on up to 275 channel MEG systems at 12 kHz sample rate. The architecture is expandable with additional processors to implement advanced processing tasks which may include e.g., continuous head localization/motion correction, optional display filters, coherence calculations, or real time synthetic channels (via beamformer). We also describe an electronics configuration upgrade to provide operator console access to the peripheral interface features such as analog signal and trigger I/O. This allows remote location of the acoustically noisy electronics cabinet and fitting of the cabinet with doors for improved EMI shielding. Finally, we present the latest performance results available for the CTF 275 channel MEG system including an unshielded SEF (median nerve electrical stimulation) measurement enhanced by application of an adaptive beamformer technique (SAM) which allows recognition of the nominal 20-ms response in the unaveraged signal. PMID:16012695

  10. Advanced transmission studies

    NASA Technical Reports Server (NTRS)

    Coy, John J.; Bill, Robert C.

    1988-01-01

    The NASA Lewis Research Center and the U.S. Army Aviation Systems Command share an interest in advancing the technology for helicopter propulsion systems. In particular, this paper presents highlights from that portion of the program in drive train technology and the related mechanical components. The major goals of the program are to increase the life, reliability, and maintainability; reduce the weight, noise, and vibration; and maintain the relatively high mechanical efficiency of the gear train. The current activity emphasizes noise reduction technology and analytical code development followed by experimental verification. Selected significant advances in technology for transmissions are reviewed, including advanced configurations and new analytical tools. Finally, the plan for future transmission research is presented.

  11. CONDOR Advanced Visionics System

    NASA Astrophysics Data System (ADS)

    Kanahele, David L.; Buckanin, Robert M.

    1996-06-01

    The Covert Night/Day Operations for Rotorcraft (CONDOR) program is a collaborative research and development program between the governments of the United States and the United Kingdom of Great Britain and Northern Ireland to develop and demonstrate an advanced visionics concept coupled with an advanced flight control system to improve rotorcraft mission effectiveness during day, night, and adverse weather conditions in the Nap- of-the-Earth environment. The Advanced Visionics System for CONDOR is the flight- ruggedized head mounted display and computer graphics generator with the intended use of exploring, developing, and evaluating proposed visionic concepts for rotorcraft including; the application of color displays, wide field-of-view, enhanced imagery, virtual displays, mission symbology, stereo imagery, and other graphical interfaces.

  12. Sensor feature fusion for detecting buried objects

    SciTech Connect

    Clark, G.A.; Sengupta, S.K.; Sherwood, R.J.; Hernandez, J.E.; Buhl, M.R.; Schaich, P.C.; Kane, R.J.; Barth, M.J.; DelGrande, N.K.

    1993-04-01

    Given multiple registered images of the earth`s surface from dual-band sensors, our system fuses information from the sensors to reduce the effects of clutter and improve the ability to detect buried or surface target sites. The sensor suite currently includes two sensors (5 micron and 10 micron wavelengths) and one ground penetrating radar (GPR) of the wide-band pulsed synthetic aperture type. We use a supervised teaming pattern recognition approach to detect metal and plastic land mines buried in soil. The overall process consists of four main parts: Preprocessing, feature extraction, feature selection, and classification. These parts are used in a two step process to classify a subimage. Thee first step, referred to as feature selection, determines the features of sub-images which result in the greatest separability among the classes. The second step, image labeling, uses the selected features and the decisions from a pattern classifier to label the regions in the image which are likely to correspond to buried mines. We extract features from the images, and use feature selection algorithms to select only the most important features according to their contribution to correct detections. This allows us to save computational complexity and determine which of the sensors add value to the detection system. The most important features from the various sensors are fused using supervised teaming pattern classifiers (including neural networks). We present results of experiments to detect buried land mines from real data, and evaluate the usefulness of fusing feature information from multiple sensor types, including dual-band infrared and ground penetrating radar. The novelty of the work lies mostly in the combination of the algorithms and their application to the very important and currently unsolved operational problem of detecting buried land mines from an airborne standoff platform.

  13. Intrinsic Feature Motion Tracking

    SciTech Connect

    Goddard, Jr., James S.

    2013-03-19

    Subject motion during 3D medical scanning can cause blurring and artifacts in the 3D images resulting in either rescans or poor diagnosis. Anesthesia or physical restraints may be used to eliminate motion but are undesirable and can affect results. This software measures the six degree of freedom 3D motion of the subject during the scan under a rigidity assumption using only the intrinsic features present on the subject area being monitored. This movement over time can then be used to correct the scan data removing the blur and artifacts. The software acquires images from external cameras or images stored on disk for processing. The images are from two or three calibrated cameras in a stereo arrangement. Algorithms extract and track the features over time and calculate position and orientation changes relative to an initial position. Output is the 3D position and orientation change measured at each image.

  14. Intrinsic Feature Motion Tracking

    2013-03-19

    Subject motion during 3D medical scanning can cause blurring and artifacts in the 3D images resulting in either rescans or poor diagnosis. Anesthesia or physical restraints may be used to eliminate motion but are undesirable and can affect results. This software measures the six degree of freedom 3D motion of the subject during the scan under a rigidity assumption using only the intrinsic features present on the subject area being monitored. This movement over timemore » can then be used to correct the scan data removing the blur and artifacts. The software acquires images from external cameras or images stored on disk for processing. The images are from two or three calibrated cameras in a stereo arrangement. Algorithms extract and track the features over time and calculate position and orientation changes relative to an initial position. Output is the 3D position and orientation change measured at each image.« less

  15. North Polar Features

    NASA Technical Reports Server (NTRS)

    2004-01-01

    28 November 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows banded terrain of the north polar region of Mars. The bands are exposures of layered material, possibly composed of dust and ice. The dark, rounded to elliptical mounds in this image might be the locations of ancient sand dunes that were completely buried in the north polar layered material. In more recent times, these mounds have been exhumed from within the layered material. Alternatively, the dark features are not ancient, exhumed dunes, but perhaps the remnants of a dark layer of material that once covered the entire area shown in the image. These features are located near 79.9oN, 31.4oW. The image covers an area about 3 km (1.9 mi) wide. Sunlight illuminates the scene from the lower left.

  16. Ontology patterns for complex topographic feature yypes

    USGS Publications Warehouse

    Varanka, Dalia E.

    2011-01-01

    Complex feature types are defined as integrated relations between basic features for a shared meaning or concept. The shared semantic concept is difficult to define in commonly used geographic information systems (GIS) and remote sensing technologies. The role of spatial relations between complex feature parts was recognized in early GIS literature, but had limited representation in the feature or coverage data models of GIS. Spatial relations are more explicitly specified in semantic technology. In this paper, semantics for topographic feature ontology design patterns (ODP) are developed as data models for the representation of complex features. In the context of topographic processes, component assemblages are supported by resource systems and are found on local landscapes. The topographic ontology is organized across six thematic modules that can account for basic feature types, resource systems, and landscape types. Types of complex feature attributes include location, generative processes and physical description. Node/edge networks model standard spatial relations and relations specific to topographic science to represent complex features. To demonstrate these concepts, data from The National Map of the U. S. Geological Survey was converted and assembled into ODP.

  17. Advanced gearbox technology

    NASA Technical Reports Server (NTRS)

    Anderson, N. E.; Cedoz, R. W.; Salama, E. E.; Wagner, D. A.

    1987-01-01

    An advanced 13,000 HP, counterrotating (CR) gearbox was designed and successfully tested to provide a technology base for future designs of geared propfan propulsion systems for both commercial and military aircraft. The advanced technology CR gearbox was designed for high efficiency, low weight, long life, and improved maintainability. The differential planetary CR gearbox features double helical gears, double row cylindrical roller bearings integral with planet gears, tapered roller prop support bearings, and a flexible ring gear and diaphragm to provide load sharing. A new Allison propfan back-to-back gearbox test facility was constructed. Extensive rotating and stationary instrumentation was used to measure temperature, strain, vibration, deflection and efficiency under representative flight operating conditions. The tests verified smooth, efficient gearbox operation. The highly-instrumented advanced CR gearbox was successfully tested to design speed and power (13,000 HP), and to a 115 percent overspeed condition. Measured CR gearbox efficiency was 99.3 percent at the design point based on heat loss to the oil. Tests demonstrated low vibration characteristics of double helical gearing, proper gear tooth load sharing, low stress levels, and the high load capacity of the prop tapered roller bearings. Applied external prop loads did not significantly affect gearbox temperature, vibration, or stress levels. Gearbox hardware was in excellent condition after the tests with no indication of distress.

  18. Automated Extraction of Flow Features

    NASA Technical Reports Server (NTRS)

    Dorney, Suzanne (Technical Monitor); Haimes, Robert

    2005-01-01

    Computational Fluid Dynamics (CFD) simulations are routinely performed as part of the design process of most fluid handling devices. In order to efficiently and effectively use the results of a CFD simulation, visualization tools are often used. These tools are used in all stages of the CFD simulation including pre-processing, interim-processing, and post-processing, to interpret the results. Each of these stages requires visualization tools that allow one to examine the geometry of the device, as well as the partial or final results of the simulation. An engineer will typically generate a series of contour and vector plots to better understand the physics of how the fluid is interacting with the physical device. Of particular interest are detecting features such as shocks, re-circulation zones, and vortices (which will highlight areas of stress and loss). As the demand for CFD analyses continues to increase the need for automated feature extraction capabilities has become vital. In the past, feature extraction and identification were interesting concepts, but not required in understanding the physics of a steady flow field. This is because the results of the more traditional tools like; isc-surface, cuts and streamlines, were more interactive and easily abstracted so they could be represented to the investigator. These tools worked and properly conveyed the collected information at the expense of a great deal of interaction. For unsteady flow-fields, the investigator does not have the luxury of spending time scanning only one "snapshot" of the simulation. Automated assistance is required in pointing out areas of potential interest contained within the flow. This must not require a heavy compute burden (the visualization should not significantly slow down the solution procedure for co-processing environments). Methods must be developed to abstract the feature of interest and display it in a manner that physically makes sense.

  19. Feature detection for spatial templates

    SciTech Connect

    Robinson, K.

    1996-02-01

    The Color Medical Image System (CMIS), a program that uses segmented mapping techniques to obtain high resolution digital images, is currently trying to develop techniques to transfer microscopic glass slides to electronic image libraries. One technique that has been attempted is to use correlation techniques to scan the image. However, when segments of high magnification are used, it is difficult and time consuming to perform correlation techniques. This project investigates feature detection in microscopic images. Various techniques are implemented to detect the section of the image containing the most feature information, thereby making the correlation process more efficient. Three tests are implemented that eliminate the background in the image and calculate the mean (1st order technique), variance (2nd order technique), and ratio test (1st order technique) of the remaining pixel values. Background elimination involves deleting all pixel values above a certain experimental value from any calculations made. The source code for each of the three tests was implemented and tested on a number of images using the green color band. Each program outputs the box containing the most features and writes that section to a file to be displayed to the screen. A visual rank was also recorded so as to compare it the output of the tests. Each of the three tests proved to be successful. After comparing the visual rank to the output of the tests, it was determined that both first and second order techniques are effective in detecting features in microscopic images. Although all of the purposes and goals were met, this investigation should be expanded to include texturized images and the use of all three color bands.

  20. Isidis Planitia Features

    NASA Technical Reports Server (NTRS)

    2004-01-01

    26 June 2004 This Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) image shows some of the most typical features of Isidis Planitia at full (1.5 meters -- 5 feet -- per pixel) resolution. The typical features are: (1) light-toned, ripple-like dunes and (2) mounds with summit pits. The dunes are formed by wind. The double-cone feature in the lower right quarter of the image is similar to many mounds and chains of mounds or cones found all across Isidis Planitia. These were seen at lower resolution in Viking orbiter images in the 1970s and were generally considered to be either small volcanoes or ice-cored mounds known as pingoes. With high resolution MOC images, it became apparent that many of these mounds may simply be the remnants of crater and pit chain floors, elevated above the surrounding plains as the layers of rock into which they formed were stripped away. Like much of Mars, there are more questions than answers. This image is located near 8.6oN, 268.2oW, and covers an area about 1.1 km (0.7 mi) wide. Sunlight illuminates the scene from the left/lower left.

  1. Ceraunius Tholus Feature

    NASA Technical Reports Server (NTRS)

    2004-01-01

    11 December 2004 Today's Mars Picture of the Day features two images. The top picture is a mosaic of Viking orbiter images acquired in the late 1970s. The lower image is a high resolution picture from the Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC). The Viking mosaic shows Ceraunius Tholus, a volcano in the Tharsis region that was first viewed in images obtained by Mariner 9 in 1972. Several channels run down the slope of the Ceraunius Tholus volcano. The deepest of those channels ends in an elliptical crater. The elliptical crater was formed by a very oblique meteor impact. Where the channel meets the floor of the elliptical crater, there is a small mound of material. Presumably, this material was deposited in the elliptical crater after running down through the channel on the volcano's northwest flank.

    Near the top/center of the mound in the elliptical crater is a small, circular depression. Some have speculated for years that this depression is related to volcanism, others thought that it may be an impact crater. The MGS MOC image (lower of the two images) shows that crater. It is not the source of lava flows or any other volcanic features. Most likely, it is an old impact crater. This feature is located near 25.2oN, 97.7oW. The MOC image covers an area approximately 3 km (1.9 mi) wide and is illuminated by sunlight from the lower left.

  2. Predicting Epileptic Seizures in Advance

    PubMed Central

    Moghim, Negin; Corne, David W.

    2014-01-01

    Epilepsy is the second most common neurological disorder, affecting 0.6–0.8% of the world's population. In this neurological disorder, abnormal activity of the brain causes seizures, the nature of which tend to be sudden. Antiepileptic Drugs (AEDs) are used as long-term therapeutic solutions that control the condition. Of those treated with AEDs, 35% become resistant to medication. The unpredictable nature of seizures poses risks for the individual with epilepsy. It is clearly desirable to find more effective ways of preventing seizures for such patients. The automatic detection of oncoming seizures, before their actual onset, can facilitate timely intervention and hence minimize these risks. In addition, advance prediction of seizures can enrich our understanding of the epileptic brain. In this study, drawing on the body of work behind automatic seizure detection and prediction from digitised Invasive Electroencephalography (EEG) data, a prediction algorithm, ASPPR (Advance Seizure Prediction via Pre-ictal Relabeling), is described. ASPPR facilitates the learning of predictive models targeted at recognizing patterns in EEG activity that are in a specific time window in advance of a seizure. It then exploits advanced machine learning coupled with the design and selection of appropriate features from EEG signals. Results, from evaluating ASPPR independently on 21 different patients, suggest that seizures for many patients can be predicted up to 20 minutes in advance of their onset. Compared to benchmark performance represented by a mean S1-Score (harmonic mean of Sensitivity and Specificity) of 90.6% for predicting seizure onset between 0 and 5 minutes in advance, ASPPR achieves mean S1-Scores of: 96.30% for prediction between 1 and 6 minutes in advance, 96.13% for prediction between 8 and 13 minutes in advance, 94.5% for prediction between 14 and 19 minutes in advance, and 94.2% for prediction between 20 and 25 minutes in advance. PMID:24911316

  3. Recent Advances in Thermionic Cathodes

    SciTech Connect

    Ives, R. Lawrence; Miram, George; Collins, George; Falce, Louis R.

    2010-11-04

    The latest advances in thermionic cathodes, including scandate and controlled porosity reservoir cathodes, are reviewed. These new cathodes provide improved performance over conventional cathodes for many applications. Advantages and disadvantages are presented.

  4. 47 CFR 65.820 - Included items.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... working capital allowance using the following formula. (1) Compute the weighted average revenue lag days... for interstate revenues billed in advance by the percentage of interstate revenues billed in advance...) and (ii) of this section to determine the weighted average revenue lag days. (2) Compute the...

  5. 31. SECTIONS AND DETAILS OF ARVFS FACILITY, INCLUDING RADIATION HAZARD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. SECTIONS AND DETAILS OF ARVFS FACILITY, INCLUDING RADIATION HAZARD SIGN, WOOD RETAINING WALL, TANK COVER, AND DRAIN BOX. F.C. TORKELSON DRAWING NUMBER 842-ARVFS-701-3. INEL INDEX CODE NUMBER: 075 0701 851 151972. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

  6. Advanced Adaptive Optics Technology Development

    SciTech Connect

    Olivier, S

    2001-09-18

    The NSF Center for Adaptive Optics (CfAO) is supporting research on advanced adaptive optics technologies. CfAO research activities include development and characterization of micro-electro-mechanical systems (MEMS) deformable mirror (DM) technology, as well as development and characterization of high-resolution adaptive optics systems using liquid crystal (LC) spatial light modulator (SLM) technology. This paper presents an overview of the CfAO advanced adaptive optics technology development activities including current status and future plans.

  7. Advanced LIGO

    NASA Astrophysics Data System (ADS)

    LIGO Scientific Collaboration; Aasi, J.; Abbott, B. P.; Abbott, R.; Abbott, T.; Abernathy, M. R.; Ackley, K.; Adams, C.; Adams, T.; Addesso, P.; Adhikari, R. X.; Adya, V.; Affeldt, C.; Aggarwal, N.; Aguiar, O. D.; Ain, A.; Ajith, P.; Alemic, A.; Allen, B.; Amariutei, D.; Anderson, S. B.; Anderson, W. G.; Arai, K.; Araya, M. C.; Arceneaux, C.; Areeda, J. S.; Ashton, G.; Ast, S.; Aston, S. M.; Aufmuth, P.; Aulbert, C.; Aylott, B. E.; Babak, S.; Baker, P. T.; Ballmer, S. W.; Barayoga, J. C.; Barbet, M.; Barclay, S.; Barish, B. C.; Barker, D.; Barr, B.; Barsotti, L.; Bartlett, J.; Barton, M. A.; Bartos, I.; Bassiri, R.; Batch, J. C.; Baune, C.; Behnke, B.; Bell, A. S.; Bell, C.; Benacquista, M.; Bergman, J.; Bergmann, G.; Berry, C. P. L.; Betzwieser, J.; Bhagwat, S.; Bhandare, R.; Bilenko, I. A.; Billingsley, G.; Birch, J.; Biscans, S.; Biwer, C.; Blackburn, J. K.; Blackburn, L.; Blair, C. D.; Blair, D.; Bock, O.; Bodiya, T. P.; Bojtos, P.; Bond, C.; Bork, R.; Born, M.; Bose, Sukanta; Brady, P. R.; Braginsky, V. B.; Brau, J. E.; Bridges, D. O.; Brinkmann, M.; Brooks, A. F.; Brown, D. A.; Brown, D. D.; Brown, N. M.; Buchman, S.; Buikema, A.; Buonanno, A.; Cadonati, L.; Calderón Bustillo, J.; Camp, J. B.; Cannon, K. C.; Cao, J.; Capano, C. D.; Caride, S.; Caudill, S.; Cavaglià, M.; Cepeda, C.; Chakraborty, R.; Chalermsongsak, T.; Chamberlin, S. J.; Chao, S.; Charlton, P.; Chen, Y.; Cho, H. S.; Cho, M.; Chow, J. H.; Christensen, N.; Chu, Q.; Chung, S.; Ciani, G.; Clara, F.; Clark, J. A.; Collette, C.; Cominsky, L.; Constancio, M., Jr.; Cook, D.; Corbitt, T. R.; Cornish, N.; Corsi, A.; Costa, C. A.; Coughlin, M. W.; Countryman, S.; Couvares, P.; Coward, D. M.; Cowart, M. J.; Coyne, D. C.; Coyne, R.; Craig, K.; Creighton, J. D. E.; Creighton, T. D.; Cripe, J.; Crowder, S. G.; Cumming, A.; Cunningham, L.; Cutler, C.; Dahl, K.; Dal Canton, T.; Damjanic, M.; Danilishin, S. L.; Danzmann, K.; Dartez, L.; Dave, I.; Daveloza, H.; Davies, G. S.; Daw, E. J.; DeBra, D.; Del Pozzo, W.; Denker, T.; Dent, T.; Dergachev, V.; DeRosa, R. T.; DeSalvo, R.; Dhurandhar, S.; D´ıaz, M.; Di Palma, I.; Dojcinoski, G.; Dominguez, E.; Donovan, F.; Dooley, K. L.; Doravari, S.; Douglas, R.; Downes, T. P.; Driggers, J. C.; Du, Z.; Dwyer, S.; Eberle, T.; Edo, T.; Edwards, M.; Edwards, M.; Effler, A.; Eggenstein, H.-B.; Ehrens, P.; Eichholz, J.; Eikenberry, S. S.; Essick, R.; Etzel, T.; Evans, M.; Evans, T.; Factourovich, M.; Fairhurst, S.; Fan, X.; Fang, Q.; Farr, B.; Farr, W. M.; Favata, M.; Fays, M.; Fehrmann, H.; Fejer, M. M.; Feldbaum, D.; Ferreira, E. C.; Fisher, R. P.; Frei, Z.; Freise, A.; Frey, R.; Fricke, T. T.; Fritschel, P.; Frolov, V. V.; Fuentes-Tapia, S.; Fulda, P.; Fyffe, M.; Gair, J. R.; Gaonkar, S.; Gehrels, N.; Gergely, L. Á.; Giaime, J. A.; Giardina, K. D.; Gleason, J.; Goetz, E.; Goetz, R.; Gondan, L.; González, G.; Gordon, N.; Gorodetsky, M. L.; Gossan, S.; Goßler, S.; Gräf, C.; Graff, P. B.; Grant, A.; Gras, S.; Gray, C.; Greenhalgh, R. J. S.; Gretarsson, A. M.; Grote, H.; Grunewald, S.; Guido, C. J.; Guo, X.; Gushwa, K.; Gustafson, E. K.; Gustafson, R.; Hacker, J.; Hall, E. D.; Hammond, G.; Hanke, M.; Hanks, J.; Hanna, C.; Hannam, M. D.; Hanson, J.; Hardwick, T.; Harry, G. M.; Harry, I. W.; Hart, M.; Hartman, M. T.; Haster, C.-J.; Haughian, K.; Hee, S.; Heintze, M.; Heinzel, G.; Hendry, M.; Heng, I. S.; Heptonstall, A. W.; Heurs, M.; Hewitson, M.; Hild, S.; Hoak, D.; Hodge, K. A.; Hollitt, S. E.; Holt, K.; Hopkins, P.; Hosken, D. J.; Hough, J.; Houston, E.; Howell, E. J.; Hu, Y. M.; Huerta, E.; Hughey, B.; Husa, S.; Huttner, S. H.; Huynh, M.; Huynh-Dinh, T.; Idrisy, A.; Indik, N.; Ingram, D. R.; Inta, R.; Islas, G.; Isler, J. C.; Isogai, T.; Iyer, B. R.; Izumi, K.; Jacobson, M.; Jang, H.; Jawahar, S.; Ji, Y.; Jiménez-Forteza, F.; Johnson, W. W.; Jones, D. I.; Jones, R.; Ju, L.; Haris, K.; Kalogera, V.; Kandhasamy, S.; Kang, G.; Kanner, J. B.; Katsavounidis, E.; Katzman, W.; Kaufer, H.; Kaufer, S.; Kaur, T.; Kawabe, K.; Kawazoe, F.; Keiser, G. M.; Keitel, D.; Kelley, D. B.; Kells, W.; Keppel, D. G.; Key, J. S.; Khalaidovski, A.; Khalili, F. Y.; Khazanov, E. A.; Kim, C.; Kim, K.; Kim, N. G.; Kim, N.; Kim, Y.-M.; King, E. J.; King, P. J.; Kinzel, D. L.; Kissel, J. S.; Klimenko, S.; Kline, J.; Koehlenbeck, S.; Kokeyama, K.; Kondrashov, V.; Korobko, M.; Korth, W. Z.; Kozak, D. B.; Kringel, V.; Krishnan, B.; Krueger, C.; Kuehn, G.; Kumar, A.; Kumar, P.; Kuo, L.; Landry, M.; Lantz, B.; Larson, S.; Lasky, P. D.; Lazzarini, A.; Lazzaro, C.; Le, J.; Leaci, P.; Leavey, S.; Lebigot, E. O.; Lee, C. H.; Lee, H. K.; Lee, H. M.; Leong, J. R.; Levin, Y.; Levine, B.; Lewis, J.; Li, T. G. F.; Libbrecht, K.; Libson, A.; Lin, A. C.; Littenberg, T. B.; Lockerbie, N. A.; Lockett, V.; Logue, J.; Lombardi, A. L.; Lormand, M.; Lough, J.; Lubinski, M. J.; Lück, H.; Lundgren, A. P.; Lynch, R.; Ma, Y.; Macarthur, J.; MacDonald, T.; Machenschalk, B.; MacInnis, M.; Macleod, D. M.; Magaña-Sandoval, F.; Magee, R.; Mageswaran, M.; Maglione, C.; Mailand, K.; Mandel, I.; Mandic, V.; Mangano, V.; Mansell, G. L.; Márka, S.; Márka, Z.; Markosyan, A.; Maros, E.; Martin, I. W.; Martin, R. M.; Martynov, D.; Marx, J. N.; Mason, K.; Massinger, T. J.; Matichard, F.; Matone, L.; Mavalvala, N.; Mazumder, N.; Mazzolo, G.; McCarthy, R.; McClelland, D. E.; McCormick, S.; McGuire, S. C.; McIntyre, G.; McIver, J.; McLin, K.; McWilliams, S.; Meadors, G. D.; Meinders, M.; Melatos, A.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messenger, C.; Meyers, P. M.; Miao, H.; Middleton, H.; Mikhailov, E. E.; Miller, A.; Miller, J.; Millhouse, M.; Ming, J.; Mirshekari, S.; Mishra, C.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Moe, B.; Mohanty, S. D.; Mohapatra, S. R. P.; Moore, B.; Moraru, D.; Moreno, G.; Morriss, S. R.; Mossavi, K.; Mow-Lowry, C. M.; Mueller, C. L.; Mueller, G.; Mukherjee, S.; Mullavey, A.; Munch, J.; Murphy, D.; Murray, P. G.; Mytidis, A.; Nash, T.; Nayak, R. K.; Necula, V.; Nedkova, K.; Newton, G.; Nguyen, T.; Nielsen, A. B.; Nissanke, S.; Nitz, A. H.; Nolting, D.; Normandin, M. E. N.; Nuttall, L. K.; Ochsner, E.; O'Dell, J.; Oelker, E.; Ogin, G. H.; Oh, J. J.; Oh, S. H.; Ohme, F.; Oppermann, P.; Oram, R.; O'Reilly, B.; Ortega, W.; O'Shaughnessy, R.; Osthelder, C.; Ott, C. D.; Ottaway, D. J.; Ottens, R. S.; Overmier, H.; Owen, B. J.; Padilla, C.; Pai, A.; Pai, S.; Palashov, O.; Pal-Singh, A.; Pan, H.; Pankow, C.; Pannarale, F.; Pant, B. C.; Papa, M. A.; Paris, H.; Patrick, Z.; Pedraza, M.; Pekowsky, L.; Pele, A.; Penn, S.; Perreca, A.; Phelps, M.; Pierro, V.; Pinto, I. M.; Pitkin, M.; Poeld, J.; Post, A.; Poteomkin, A.; Powell, J.; Prasad, J.; Predoi, V.; Premachandra, S.; Prestegard, T.; Price, L. R.; Principe, M.; Privitera, S.; Prix, R.; Prokhorov, L.; Puncken, O.; Pürrer, M.; Qin, J.; Quetschke, V.; Quintero, E.; Quiroga, G.; Quitzow-James, R.; Raab, F. J.; Rabeling, D. S.; Radkins, H.; Raffai, P.; Raja, S.; Rajalakshmi, G.; Rakhmanov, M.; Ramirez, K.; Raymond, V.; Reed, C. M.; Reid, S.; Reitze, D. H.; Reula, O.; Riles, K.; Robertson, N. A.; Robie, R.; Rollins, J. G.; Roma, V.; Romano, J. D.; Romanov, G.; Romie, J. H.; Rowan, S.; Rüdiger, A.; Ryan, K.; Sachdev, S.; Sadecki, T.; Sadeghian, L.; Saleem, M.; Salemi, F.; Sammut, L.; Sandberg, V.; Sanders, J. R.; Sannibale, V.; Santiago-Prieto, I.; Sathyaprakash, B. S.; Saulson, P. R.; Savage, R.; Sawadsky, A.; Scheuer, J.; Schilling, R.; Schmidt, P.; Schnabel, R.; Schofield, R. M. S.; Schreiber, E.; Schuette, D.; Schutz, B. F.; Scott, J.; Scott, S. M.; Sellers, D.; Sengupta, A. S.; Sergeev, A.; Serna, G.; Sevigny, A.; Shaddock, D. A.; Shahriar, M. S.; Shaltev, M.; Shao, Z.; Shapiro, B.; Shawhan, P.; Shoemaker, D. H.; Sidery, T. L.; Siemens, X.; Sigg, D.; Silva, A. D.; Simakov, D.; Singer, A.; Singer, L.; Singh, R.; Sintes, A. M.; Slagmolen, B. J. J.; Smith, J. R.; Smith, M. R.; Smith, R. J. E.; Smith-Lefebvre, N. D.; Son, E. J.; Sorazu, B.; Souradeep, T.; Staley, A.; Stebbins, J.; Steinke, M.; Steinlechner, J.; Steinlechner, S.; Steinmeyer, D.; Stephens, B. C.; Steplewski, S.; Stevenson, S.; Stone, R.; Strain, K. A.; Strigin, S.; Sturani, R.; Stuver, A. L.; Summerscales, T. Z.; Sutton, P. J.; Szczepanczyk, M.; Szeifert, G.; Talukder, D.; Tanner, D. B.; Tápai, M.; Tarabrin, S. P.; Taracchini, A.; Taylor, R.; Tellez, G.; Theeg, T.; Thirugnanasambandam, M. P.; Thomas, M.; Thomas, P.; Thorne, K. A.; Thorne, K. S.; Thrane, E.; Tiwari, V.; Tomlinson, C.; Torres, C. V.; Torrie, C. I.; Traylor, G.; Tse, M.; Tshilumba, D.; Ugolini, D.; Unnikrishnan, C. S.; Urban, A. L.; Usman, S. A.; Vahlbruch, H.; Vajente, G.; Valdes, G.; Vallisneri, M.; van Veggel, A. A.; Vass, S.; Vaulin, R.; Vecchio, A.; Veitch, J.; Veitch, P. J.; Venkateswara, K.; Vincent-Finley, R.; Vitale, S.; Vo, T.; Vorvick, C.; Vousden, W. D.; Vyatchanin, S. P.; Wade, A. R.; Wade, L.; Wade, M.; Walker, M.; Wallace, L.; Walsh, S.; Wang, H.; Wang, M.; Wang, X.; Ward, R. L.; Warner, J.; Was, M.; Weaver, B.; Weinert, M.; Weinstein, A. J.; Weiss, R.; Welborn, T.; Wen, L.; Wessels, P.; Westphal, T.; Wette, K.; Whelan, J. T.; Whitcomb, S. E.; White, D. J.; Whiting, B. F.; Wilkinson, C.; Williams, L.; Williams, R.; Williamson, A. R.; Willis, J. L.; Willke, B.; Wimmer, M.; Winkler, W.; Wipf, C. C.; Wittel, H.; Woan, G.; Worden, J.; Xie, S.; Yablon, J.; Yakushin, I.; Yam, W.; Yamamoto, H.; Yancey, C. C.; Yang, Q.; Zanolin, M.; Zhang, Fan; Zhang, L.; Zhang, M.; Zhang, Y.; Zhao, C.; Zhou, M.; Zhu, X. J.; Zucker, M. E.; Zuraw, S.; Zweizig, J.

    2015-04-01

    The Advanced LIGO gravitational wave detectors are second-generation instruments designed and built for the two LIGO observatories in Hanford, WA and Livingston, LA, USA. The two instruments are identical in design, and are specialized versions of a Michelson interferometer with 4 km long arms. As in Initial LIGO, Fabry-Perot cavities are used in the arms to increase the interaction time with a gravitational wave, and power recycling is used to increase the effective laser power. Signal recycling has been added in Advanced LIGO to improve the frequency response. In the most sensitive frequency region around 100 Hz, the design strain sensitivity is a factor of 10 better than Initial LIGO. In addition, the low frequency end of the sensitivity band is moved from 40 Hz down to 10 Hz. All interferometer components have been replaced with improved technologies to achieve this sensitivity gain. Much better seismic isolation and test mass suspensions are responsible for the gains at lower frequencies. Higher laser power, larger test masses and improved mirror coatings lead to the improved sensitivity at mid and high frequencies. Data collecting runs with these new instruments are planned to begin in mid-2015.

  8. Earth feature identification and tracking technology development

    NASA Technical Reports Server (NTRS)

    Wilson, R. G.; Sivertson, W. E., Jr.

    1979-01-01

    The paper discusses needs for smart sensing in terrestrial and atmospheric remote sensing as related to current technology and a scheduled Shuttle experiment. An approach is outlined involving Shuttle-borne experiments to develop earth feature identification and tracking technology including a Feature Identification and Location Experiment (FILE) scheduled for flight on the NASA Shuttle with an objective of classifying earth features into categories of bare land, water, vegetation, and clouds, snow, and ice. The plan for evolution of the FILE-related technology leads to capabilities for pointing instruments to predetermined sites, reacquiring earth features or landmarks, and tracking features such as coastlines and rivers. Technology concepts relative to an overall system transfer function is discussed, and the development status outlined.

  9. New features in Delphes 3

    NASA Astrophysics Data System (ADS)

    Mertens, Alexandre

    2015-05-01

    Delphes is an open source C++ framework to perform the fast simulation of the response of a multipurpose detector. The simulation includes a tracking system, embedded into a magnetic field, calorimeters and a muon system. The framework is interfaced to standard file formats and outputs observables such as isolated leptons, missing transverse energy and collection of jets that can be used for dedicated analyses. The simulation of the detector response takes into account the effect of magnetic field, the granularity of the calorimeters and subdetector resolutions. The program contains parmetrizations for the CMS and ATLAS detectors, based on published performances. Basic parametrizations for the LHCb and FCC detectors are also available. The Delphes framework also includes a simple event display. Several new features are discussed, such as an emulation of the particle-flow algorithm, pile- up simulation, N-subjettiness and a simple b-tagging algorithm based on counting tracks with large impact parameter.

  10. Advanced ballistic range technology

    NASA Technical Reports Server (NTRS)

    Yates, Leslie A.

    1992-01-01

    Experimental interferograms, schlieren, and shadow-graphs are routinely used for validating ideal- and real-gas computational fluid dynamics (CFD) codes. Interferograms are used for quantitative comparisons of integrated density. Schlieren and shadowgraphs are used for comparing the locations of flow field features; the types of flowfield features recorded in these images include shocks, shear layers, and expansion fans. By constructing images from flow field simulations, one-to-one comparisons of computation and experiment are possible. During the period from 1 May 1991 to 31 Jan. 1992, the emphasis of this research was on developing techniques for constructing these images from flow field simulations.

  11. Feature Profile Simulations and Finite Penetration Depth

    NASA Astrophysics Data System (ADS)

    Moroz, Paul; Moroz, Daniel

    2012-10-01

    In plasma materials processing, energetic ions, neutrals and UV photons typically penetrate deep inside solid materials breaking atomic bonds and displacing atoms on their paths. These important phenomena are rarely taken into consideration in processing simulation software, primarily because the proper penetration depths and the corresponding energy depositions, breaking bonds, and atom displacements are difficult and computationally expensive to compute. The FPS-3D feature profile simulator [1-2] is doing that computationally efficiently by utilizing tabulated results obtained with other methods. We discuss, compare, and present results of such simulations made with different methods, one of which is the molecular dynamics analysis. In general, molecular dynamics could be used for simulating materials processing, etching and deposition, but it is extremely computationally expensive to be used for large groups of atoms. In practice, molecular dynamics methods are too slow to be used for feature profile simulations. However, they could help in defining proper chemical reactions and corresponding rates to be used in an advanced feature profile simulator such as FPS-3D. We present results of FPS-3D simulations for Si and SiO2 etching in Ar/Cl2 and Ar/C4F6/O2 plasmas. [4pt] [1] P. Moroz, ``General Feature Profile Simulator FPS-3D,'' ECS Transactions, 35, 25 (2011). [0pt] [2] P. Moroz, ``Numerical Simulation of Feature Profile Evolution using FPS-3D,'' IEEE Transactions of Plasma Science, 39, 2804 (2011).

  12. Feature extraction through LOCOCODE.

    PubMed

    Hochreiter, S; Schmidhuber, J

    1999-04-01

    Low-complexity coding and decoding (LOCOCODE) is a novel approach to sensory coding and unsupervised learning. Unlike previous methods, it explicitly takes into account the information-theoretic complexity of the code generator. It computes lococodes that convey information about the input data and can be computed and decoded by low-complexity mappings. We implement LOCOCODE by training autoassociators with flat minimum search, a recent, general method for discovering low-complexity neural nets. It turns out that this approach can unmix an unknown number of independent data sources by extracting a minimal number of low-complexity features necessary for representing the data. Experiments show that unlike codes obtained with standard autoencoders, lococodes are based on feature detectors, never unstructured, usually sparse, and sometimes factorial or local (depending on statistical properties of the data). Although LOCOCODE is not explicitly designed to enforce sparse or factorial codes, it extracts optimal codes for difficult versions of the "bars" benchmark problem, whereas independent component analysis (ICA) and principal component analysis (PCA) do not. It produces familiar, biologically plausible feature detectors when applied to real-world images and codes with fewer bits per pixel than ICA and PCA. Unlike ICA, it does not need to know the number of independent sources. As a preprocessor for a vowel recognition benchmark problem, it sets the stage for excellent classification performance. Our results reveal an interesting, previously ignored connection between two important fields: regularizer research and ICA-related research. They may represent a first step toward unification of regularization and unsupervised learning.

  13. Features of MCNP6

    NASA Astrophysics Data System (ADS)

    Goorley, T.; James, M.; Booth, T.; Brown, F.; Bull, J.; Cox, L. J.; Durkee, J.; Elson, J.; Fensin, M.; Forster, R. A.; Hendricks, J.; Hughes, H. G.; Johns, R.; Kiedrowski, B.; Martz, R.; Mashnik, S.; McKinney, G.; Pelowitz, D.; Prael, R.; Sweezy, J.; Waters, L.; Wilcox, T.; Zukaitis, T.

    2014-06-01

    MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, but it is much more than the sum of these two computer codes. MCNP6 is the result of six years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in Los Alamos National Laboratory's X Computational Physics Division, Monte Carlo Codes Group (XCP-3) and Nuclear Engineering and Nonproliferation Division, Radiation Transport Modeling Team (NEN-5) respectively, have combined their code development efforts to produce the next evolution of MCNP. While maintenance and major bug fixes will continue for MCNP5 1.60 and MCNPX 2.7.0 for upcoming years, new code development capabilities only will be developed and released in MCNP6. In fact, the initial release of MCNP6 contains numerous new features not previously found in either code. These new features are summarized in this document. Packaged with MCNP6 is also the new production release of the ENDF/B-VII.1 nuclear data files usable by MCNP. The high quality of the overall merged code, usefulness of these new features, along with the desire in the user community to start using the merged code, have led us to make the first MCNP6 production release: MCNP6 version 1. High confidence in the MCNP6 code is based on its performance with the verification and validation test suites, comparisons to its predecessor codes, our automated nightly software debugger tests, the underlying high quality nuclear and atomic databases, and significant testing by many beta testers.

  14. Simultaneous Channel and Feature Selection of Fused EEG Features Based on Sparse Group Lasso

    PubMed Central

    Wang, Jin-Jia; Xue, Fang; Li, Hui

    2015-01-01

    Feature extraction and classification of EEG signals are core parts of brain computer interfaces (BCIs). Due to the high dimension of the EEG feature vector, an effective feature selection algorithm has become an integral part of research studies. In this paper, we present a new method based on a wrapped Sparse Group Lasso for channel and feature selection of fused EEG signals. The high-dimensional fused features are firstly obtained, which include the power spectrum, time-domain statistics, AR model, and the wavelet coefficient features extracted from the preprocessed EEG signals. The wrapped channel and feature selection method is then applied, which uses the logistical regression model with Sparse Group Lasso penalized function. The model is fitted on the training data, and parameter estimation is obtained by modified blockwise coordinate descent and coordinate gradient descent method. The best parameters and feature subset are selected by using a 10-fold cross-validation. Finally, the test data is classified using the trained model. Compared with existing channel and feature selection methods, results show that the proposed method is more suitable, more stable, and faster for high-dimensional feature fusion. It can simultaneously achieve channel and feature selection with a lower error rate. The test accuracy on the data used from international BCI Competition IV reached 84.72%. PMID:25802861

  15. Onychomatricoma with misleading features.

    PubMed

    Fayol, J; Baran, R; Perrin, C; Labrousse, F

    2000-01-01

    Onychomatricoma is a rare tumour of the nail matrix with peculiar clinical and histological features and electron microscopic findings. We report on 5 cases with appearances which were misleading. Three presented as longitudinal melanonychia, a previously unreported observation. One case had the appearance of a cutaneous horn. In 3 of the 5 cases the tumour was associated with an onychomycosis and this may thus have been a predisposing factor in the secondary fungal infestation. Onychomatricoma appears as a multi-faceted tumour which can be mimicked by longitudinal melanonychia and/or onychomycosis. PMID:11200837

  16. MCNP4A: Features and philosophy

    SciTech Connect

    Hendricks, J.S.

    1993-05-01

    This paper describes MCNP, states its philosophy, introduces a number of new features becoming available with version MCNP4A, and answers a number of questions asked by participants in the workshop. MCNP is a general-purpose three-dimensional neutron, photon and electron transport code. Its philosophy is ``Quality, Value and New Features.`` Quality is exemplified by new software quality assurance practices and a program of benchmarking against experiments. Value includes a strong emphasis on documentation and code portability. New features are the third priority. MCNP4A is now available at Los Alamos. New features in MCNP4A include enhanced statistical analysis, distributed processor multitasking, new photon libraries, ENDF/B-VI capabilities, X-Windows graphics, dynamic memory allocation, expanded criticality output, periodic boundaries, plotting of particle tracks via SABRINA, and many other improvements. 23 refs.

  17. Structural Features of Algebraic Quantum Notations

    ERIC Educational Resources Information Center

    Gire, Elizabeth; Price, Edward

    2015-01-01

    The formalism of quantum mechanics includes a rich collection of representations for describing quantum systems, including functions, graphs, matrices, histograms of probabilities, and Dirac notation. The varied features of these representations affect how computations are performed. For example, identifying probabilities of measurement outcomes…

  18. Advanced Life Support Systems

    NASA Technical Reports Server (NTRS)

    Barta, Daniel J.

    2004-01-01

    This presentation is planned to be a 10-15 minute "catalytic" focused presentation to be scheduled during one of the working sessions at the TIM. This presentation will focus on Advanced Life Support technologies key to future human Space Exploration as outlined in the Vision, and will include basic requirements, assessment of the state-of-the-art and gaps, and include specific technology metrics. The presentation will be technical in character, lean heavily on data in published ALS documents (such as the Baseline Values and Assumptions Document) but not provide specific technical details or build to information on any technology mentioned (thus the presentation will be benign from an export control and a new technology perspective). The topics presented will be focused on the following elements of Advanced Life Support: air revitalization, water recovery, waste management, thermal control, habitation systems, food systems and bioregenerative life support.

  19. Features in visual search combine linearly

    PubMed Central

    Pramod, R. T.; Arun, S. P.

    2014-01-01

    Single features such as line orientation and length are known to guide visual search, but relatively little is known about how multiple features combine in search. To address this question, we investigated how search for targets differing in multiple features (intensity, length, orientation) from the distracters is related to searches for targets differing in each of the individual features. We tested race models (based on reaction times) and co-activation models (based on reciprocal of reaction times) for their ability to predict multiple feature searches. Multiple feature searches were best accounted for by a co-activation model in which feature information combined linearly (r = 0.95). This result agrees with the classic finding that these features are separable i.e., subjective dissimilarity ratings sum linearly. We then replicated the classical finding that the length and width of a rectangle are integral features—in other words, they combine nonlinearly in visual search. However, to our surprise, upon including aspect ratio as an additional feature, length and width combined linearly and this model outperformed all other models. Thus, length and width of a rectangle became separable when considered together with aspect ratio. This finding predicts that searches involving shapes with identical aspect ratio should be more difficult than searches where shapes differ in aspect ratio. We confirmed this prediction on a variety of shapes. We conclude that features in visual search co-activate linearly and demonstrate for the first time that aspect ratio is a novel feature that guides visual search. PMID:24715328

  20. Global map of eolian features on Mars.

    USGS Publications Warehouse

    Ward, A.W.; Doyle, K.B.; Helm, P.J.; Weisman, M.K.; Witbeck, N.E.

    1985-01-01

    Ten basic categories of eolian features on Mars were identified from a survey of Mariner 9 and Viking orbiter images. The ten features mapped are 1) light streaks (including frost streaks), 2) dark streaks, 3) sand sheets or splotches, 4) barchan dunes, 5) transverse dunes, 6) crescentic dunes, 7) anomalous dunes, 8) yardangs, 9) wind grooves, and 10) deflation pits. The features were mapped in groups, not as individual landforms, and recorded according to their geographic positions and orientations on maps of 1:12.5 million or 1:25 million scale. -from Authors

  1. Advanced Environmental Monitoring Technologies

    NASA Technical Reports Server (NTRS)

    Jan, Darrell

    2004-01-01

    Viewgraphs on Advanced Environmental Monitoring Technologies are presented. The topics include: 1) Monitoring & Controlling the Environment; 2) Illustrative Example: Canary 3) Ground-based Commercial Technology; 4) High Capability & Low Mass/Power + Autonomy = Key to Future SpaceFlight; 5) Current Practice: in Flight; 6) Current Practice: Post Flight; 7) Miniature Mass Spectrometer for Planetary Exploration and Long Duration Human Flight; 8) Hardware and Data Acquisition System; 9) 16S rDNA Phylogenetic Tree; and 10) Preview of Porter.

  2. Recent advances on integrated quantum communications

    NASA Astrophysics Data System (ADS)

    Orieux, Adeline; Diamanti, Eleni

    2016-08-01

    In recent years, the use of integrated technologies for applications in the field of quantum information processing and communications has made great progress. The resulting devices feature valuable characteristics such as scalability, reproducibility, low cost and interconnectivity, and have the potential to revolutionize our computation and communication practices in the future, much in the way that electronic integrated circuits have drastically transformed our information processing capacities since the last century. Among the multiple applications of integrated quantum technologies, this review will focus on typical components of quantum communication systems and on overall integrated system operation characteristics. We are interested in particular in the use of photonic integration platforms for developing devices necessary in quantum communications, including sources, detectors and both passive and active optical elements. We also illustrate the challenges associated with performing quantum communications on chip, by using the case study of quantum key distribution—the most advanced application of quantum information science. We conclude with promising perspectives in this field.

  3. ATF (Advanced Toroidal Facility) data management

    SciTech Connect

    Kannan, K.L.; Baylor, L.R.

    1988-01-01

    Data management for the Advanced Toroidal Facility (ATF), a stellarator located at Oak Ridge National Laboratory (ORNL), is provided by DMG, a locally developed, VAX-based software system. DMG is a data storage and retrieval software system that provides the user interface to ATF raw and analyzed data. Data are described in terms of data models and data types and are organized as signals into files, which are internally documented. The system was designed with user accessibility, software maintainability, and extensibility as primary goals. Extensibility features include compatibility with ATF as it moves from pulsed to steady-state operation and capability for use of the DMG system with experiments other than ATF. DMG is implemented as a run-time library of routines available as a shareable image. General-purpose and specialized data acquisition and analysis applications have been developed using the DMG system. This paper describes the DMG system and the interfaces to it. 4 refs., 2 figs.

  4. The Advanced Light Source elliptically polarizing undulator

    SciTech Connect

    Marks, S.; Cortopassi, C.; DeVries, J.

    1997-05-01

    An elliptically polarizing undulator (EPU) for the Advanced Light Source (ALS) has been designed and is currently under construction. The magnetic design is a moveable quadrant pure permanent magnet structure featuring adjustable magnets to correct phase errors and on-axis field integrals. The device is designed with a 5.0 cm period and will produce variably polarized light of any ellipticity, including pure circular and linear. The spectral range at 1.9 GeV for typical elliptical polarization with a degree of circular polarization greater than 0.8 will be from 100 eV to 1,500 eV, using the first, third, and fifth harmonics. The device will be switchable between left and right circular modes at a frequency of up to 0.1 Hz. The 1.95 m long overall length will allow two such devices in a single ALS straight sector.

  5. Advanced long term cryogenic storage systems

    NASA Technical Reports Server (NTRS)

    Brown, Norman S.

    1987-01-01

    Long term, cryogenic fluid storage facilities will be required to support future space programs such as the space-based Orbital Transfer Vehicle (OTV), Telescopes, and Laser Systems. An orbital liquid oxygen/liquid hydrogen storage system with an initial capacity of approximately 200,000 lb will be required. The storage facility tank design must have the capability of fluid acquisition in microgravity and limit cryogen boiloff due to environmental heating. Cryogenic boiloff management features, minimizing Earth-to-orbit transportation costs, will include advanced thick multilayer insulation/integrated vapor cooled shield concepts, low conductance support structures, and refrigeration/reliquefaction systems. Contracted study efforts are under way to develop storage system designs, technology plans, test article hardware designs, and develop plans for ground/flight testing.

  6. The AC-120: The advanced commercial transport

    NASA Technical Reports Server (NTRS)

    Duran, David; Griffin, Ernest; Mendoza, Saul; Nguyen, Son; Pickett, Tim; Noernberg, Clemm

    1993-01-01

    The main objective of this design was to fulfill a need for a new airplane to replace the aging 100 to 150 passenger, 1500 nautical mile range aircraft such as the Douglas DC9 and Boeing 737-100 airplanes. After researching the future aircraft market, conducting extensive trade studies, and analysis on different configurations, the AC-120 Advanced Commercial Transport final design was achieved. The AC-120's main design features include the incorporation of a three lifting surface configuration which is powered by two turboprop engines. The AC-120 is an economically sensitive aircraft which meets the new FM Stage Three noise requirements, and has lower NO(x) emissions than current turbofan powered airplanes. The AC-120 also improves on its contemporaries in passenger comfort, manufacturing, and operating cost.

  7. Recursive Feature Extraction in Graphs

    SciTech Connect

    2014-08-14

    ReFeX extracts recursive topological features from graph data. The input is a graph as a csv file and the output is a csv file containing feature values for each node in the graph. The features are based on topological counts in the neighborhoods of each nodes, as well as recursive summaries of neighbors' features.

  8. The Advanced Solid Rocket Motor

    NASA Technical Reports Server (NTRS)

    Mitchell, Royce E.

    1992-01-01

    The Advanced Solid Rocket Motor will utilize improved design features and automated manufacturing methods to produce an inherently safer propulsive system for the Space Shuttle and future launch systems. This second-generation motor will also provide an additional 12,000 pounds of payload to orbit, enhancing the utility and efficiency of the Shuttle system. The new plant will feature strip-wound, asbestos-free insulation; propellant continuous mixing and casting; and extensive robotic systems. Following a series of static tests at the Stennis Space Center, MS flights are targeted to begin in early 1997.

  9. The Advanced Solid Rocket Motor

    NASA Astrophysics Data System (ADS)

    Mitchell, Royce E.

    1992-08-01

    The Advanced Solid Rocket Motor will utilize improved design features and automated manufacturing methods to produce an inherently safer propulsive system for the Space Shuttle and future launch systems. This second-generation motor will also provide an additional 12,000 pounds of payload to orbit, enhancing the utility and efficiency of the Shuttle system. The new plant will feature strip-wound, asbestos-free insulation; propellant continuous mixing and casting; and extensive robotic systems. Following a series of static tests at the Stennis Space Center, MS flights are targeted to begin in early 1997.

  10. Feature Engineering for Drug Name Recognition in Biomedical Texts: Feature Conjunction and Feature Selection

    PubMed Central

    Liu, Shengyu; Chen, Qingcai; Wang, Xiaolong; Fan, Xiaoming

    2015-01-01

    Drug name recognition (DNR) is a critical step for drug information extraction. Machine learning-based methods have been widely used for DNR with various types of features such as part-of-speech, word shape, and dictionary feature. Features used in current machine learning-based methods are usually singleton features which may be due to explosive features and a large number of noisy features when singleton features are combined into conjunction features. However, singleton features that can only capture one linguistic characteristic of a word are not sufficient to describe the information for DNR when multiple characteristics should be considered. In this study, we explore feature conjunction and feature selection for DNR, which have never been reported. We intuitively select 8 types of singleton features and combine them into conjunction features in two ways. Then, Chi-square, mutual information, and information gain are used to mine effective features. Experimental results show that feature conjunction and feature selection can improve the performance of the DNR system with a moderate number of features and our DNR system significantly outperforms the best system in the DDIExtraction 2013 challenge. PMID:25861377

  11. Feature engineering for drug name recognition in biomedical texts: feature conjunction and feature selection.

    PubMed

    Liu, Shengyu; Tang, Buzhou; Chen, Qingcai; Wang, Xiaolong; Fan, Xiaoming

    2015-01-01

    Drug name recognition (DNR) is a critical step for drug information extraction. Machine learning-based methods have been widely used for DNR with various types of features such as part-of-speech, word shape, and dictionary feature. Features used in current machine learning-based methods are usually singleton features which may be due to explosive features and a large number of noisy features when singleton features are combined into conjunction features. However, singleton features that can only capture one linguistic characteristic of a word are not sufficient to describe the information for DNR when multiple characteristics should be considered. In this study, we explore feature conjunction and feature selection for DNR, which have never been reported. We intuitively select 8 types of singleton features and combine them into conjunction features in two ways. Then, Chi-square, mutual information, and information gain are used to mine effective features. Experimental results show that feature conjunction and feature selection can improve the performance of the DNR system with a moderate number of features and our DNR system significantly outperforms the best system in the DDIExtraction 2013 challenge.

  12. Neutron Cross Section Covariances: Recent Workshop and Advanced Reactor Systems

    NASA Astrophysics Data System (ADS)

    Oblozinsky, Pavel

    2008-10-01

    The recent Workshop on Neutron Cross Section Covariances, organized by BNL and attended by more than 50 scientists, responded to demands of many user groups, including advanced reactor systems, for uncertainty and correlation information. These demands can be explained by considerable progress in advanced neutronics simulation that probe covariances and their impact on design and operational margins of nuclear systems. The Workshop addressed evaluation methodology, recent evaluations as well as user's perspective, marking era of revival of covariance development that started some two years ago. We illustrate urgent demand for covariances in the case of advanced reactor systems, including fast actinide burner under GNEP, new generation of power reactors, Gen-IV, and reactors under AFCI. A common feature of many of these systems is presence of large amount of minor actinides and fission products that require improved nuclear data. Advanced simulation codes rely on quality input, to be obtained by adjusting the data library, such as the new ENDF/B-VII.0, by considering integral experiments as currently pursued by GNEP. To this end the nuclear data community is developing covariances for formidable amount of 112 materials (isotopes).

  13. An Integrated Biochemistry Laboratory, Including Molecular Modeling

    NASA Astrophysics Data System (ADS)

    Hall, Adele J. Wolfson Mona L.; Branham, Thomas R.

    1996-11-01

    The dilemma of designing an advanced undergraduate laboratory lies in the desire to teach and reinforce basic principles and techniques while at the same time exposing students to the excitement of research. We report here on a one-semester, project-based biochemistry laboratory that combines the best features of a cookbook approach (high success rate, achievement of defined goals) with those of an investigative, discovery-based approach (student involvement in the experimental design, excitement of real research). Individual modules may be selected and combined to meet the needs of different courses and different institutions. The central theme of this lab is protein purification and design. This laboratory accompanies the first semester of biochemistry (Structure and Function of Macromolecules, a course taken mainly by junior and senior chemistry and biological chemistry majors). The protein chosen as the object of study is the enzyme lysozyme, which is utilized in all projects. It is suitable for a student lab because it is easily and inexpensively obtained from egg white and is extremely stable, and its high isoelectric point (pI = 11) allows for efficient separation from other proteins by ion-exchange chromatography. Furthermore, a literature search conducted by the resourceful student reveals a wealth of information, since lysozyme has been the subject of numerous studies. It was the first enzyme whose structure was determined by crystallography (1). Hendrickson et al. (2) have previously described an intensive one-month laboratory course centered around lysozyme, although their emphasis is on protein stability rather than purification and engineering. Lysozyme continues to be the focus of much exciting new work on protein folding and dynamics, structure and activity (3 - 5). This lab course includes the following features: (i) reinforcement of basic techniques, such as preparation of buffers, simple enzyme kinetics, and absorption spectroscopy; (ii

  14. Recent Space PV Concentrator Advances: More Robust, Lighter, and Easier to Track

    NASA Technical Reports Server (NTRS)

    O'Neill, Mark; McDanal, A. J.; Brandhorst, Henry; Schmid, Kevin; LaCorte, Peter; Piszczor, Michael; Myers, Matt

    2015-01-01

    Over the past three years, the authors have collaborated on several significant advances in space photovoltaic concentrator technology, including a far more robust Fresnel lens for sunlight concentration, improved color-mixing features for the lens to minimize chromatic aberration losses for next-generation 4-junction and 6-junction IMM cells, a new approach to suntracking requiring only one axis of rotation even in the presence of large beta angles (e.g., +/- 50 deg), a new waste heat radiator made of graphene, with 80-90% reduction in mass, and a new platform for deployment and support on orbit (SOLAROSA). These patent-pending advances are described in this paper.

  15. Three-dimensional viscous design methodology for advanced technology aircraft supersonic inlet systems

    NASA Technical Reports Server (NTRS)

    Anderson, B. H.

    1984-01-01

    A broad program to develop advanced, reliable, and user oriented three-dimensional viscous design techniques for supersonic inlet systems, and encourage their transfer into the general user community is discussed. Features of the program include: (1) develop effective methods of computing three-dimensional flows within a zonal modeling methodology; (2) ensure reasonable agreement between said analysis and selective sets of benchmark validation data; (3) develop user orientation into said analysis; and (4) explore and develop advanced numerical methodology. Previously announced in STAR as N84-13190

  16. Advanced Chemical Propulsion

    NASA Technical Reports Server (NTRS)

    Alexander, Leslie, Jr.

    2006-01-01

    Advanced Chemical Propulsion (ACP) provides near-term incremental improvements in propulsion system performance and/or cost. It is an evolutionary approach to technology development that produces useful products along the way to meet increasingly more demanding mission requirements while focusing on improving payload mass fraction to yield greater science capability. Current activities are focused on two areas: chemical propulsion component, subsystem, and manufacturing technologies that offer measurable system level benefits; and the evaluation of high-energy storable propellants with enhanced performance for in-space application. To prioritize candidate propulsion technology alternatives, a variety of propulsion/mission analyses and trades have been conducted for SMD missions to yield sufficient data for investment planning. They include: the Advanced Chemical Propulsion Assessment; an Advanced Chemical Propulsion System Model; a LOx-LH2 small pumps conceptual design; a space storables propellant study; a spacecraft cryogenic propulsion study; an advanced pressurization and mixture ratio control study; and a pump-fed vs. pressure-fed study.

  17. Dynamic features of combustion

    NASA Technical Reports Server (NTRS)

    Oppenheim, A. K.

    1985-01-01

    The dynamic features of combustion are discussed for four important cases: ignition, inflammation, explosion, and detonation. Ignition, the initiation of a self-sustained exothermic process, is considered in the simplest case of a closed thermodynamic system and its stochastic distribution. Inflammation, the initiation and propagation of self-sustained flames, is presented for turbulent flow. Explosion, the dynamic effects caused by the deposition of exothermic energy in a compressible medium, is illustrated by self-similar blast waves with energy deposition at the front and the adiabatic non-self-similar wave. Detonation, the most comprehensive illustration of all the dynamic effects of combustion, is discussed with a phenomenological account of the development and structure of the wave.

  18. Three-dimensional cardiac computational modelling: methods, features and applications.

    PubMed

    Lopez-Perez, Alejandro; Sebastian, Rafael; Ferrero, Jose M

    2015-01-01

    The combination of computational models and biophysical simulations can help to interpret an array of experimental data and contribute to the understanding, diagnosis and treatment of complex diseases such as cardiac arrhythmias. For this reason, three-dimensional (3D) cardiac computational modelling is currently a rising field of research. The advance of medical imaging technology over the last decades has allowed the evolution from generic to patient-specific 3D cardiac models that faithfully represent the anatomy and different cardiac features of a given alive subject. Here we analyse sixty representative 3D cardiac computational models developed and published during the last fifty years, describing their information sources, features, development methods and online availability. This paper also reviews the necessary components to build a 3D computational model of the heart aimed at biophysical simulation, paying especial attention to cardiac electrophysiology (EP), and the existing approaches to incorporate those components. We assess the challenges associated to the different steps of the building process, from the processing of raw clinical or biological data to the final application, including image segmentation, inclusion of substructures and meshing among others. We briefly outline the personalisation approaches that are currently available in 3D cardiac computational modelling. Finally, we present examples of several specific applications, mainly related to cardiac EP simulation and model-based image analysis, showing the potential usefulness of 3D cardiac computational modelling into clinical environments as a tool to aid in the prevention, diagnosis and treatment of cardiac diseases. PMID:25928297

  19. Advanced composites technology program

    NASA Technical Reports Server (NTRS)

    Davis, John G., Jr.

    1993-01-01

    This paper provides a brief overview of the NASA Advanced Composites Technology (ACT) Program. Critical technology issues that must be addressed and solved to develop composite primary structures for transport aircraft are delineated. The program schedule and milestones are included. Work completed in the first 3 years of the program indicates the potential for achieving composite structures that weigh less and are cost effective relative to conventional aluminum structure. Selected technical accomplishments are noted. Readers who are seeking more in-depth technical information should study the other papers included in these proceedings.

  20. Advance Directives

    MedlinePlus

    ... disease, medical care to promote your well-being ( palliative care ) continues. This type of care includes treatment to ... the patient’s behalf. Contact the National Hospice and Palliative Care Organization for more information about companies that provide ...

  1. Nondestructive evaluation of advanced ceramics

    NASA Technical Reports Server (NTRS)

    Klima, Stanley J.; Kautz, Harold E.

    1988-01-01

    A review is presented of Lewis Research Center efforts to develop nondestructive evaluation techniques for characterizing advanced ceramic materials. Various approaches involved the use of analytical ultrasonics to characterize monolythic ceramic microstructures, acousto-ultrasonics for characterizing ceramic matrix composites, damage monitoring in impact specimens by microfocus X-ray radiography and scanning ultrasonics, and high resolution computed X-ray tomography to identify structural features in fiber reinforced ceramics.

  2. Features of spherical torus plasmas

    SciTech Connect

    Peng, Y.K.M.; Strickler, D.J.

    1985-12-01

    The spherical torus is a very small aspect ratio (A < 2) confinement concept obtained by retaining only the indispensable components inboard to the plasma torus. MHD equilibrium calculations show that spherical torus plasmas with safety factor q > 2 are characterized by high toroidal beta (..beta../sub t/ > 0.2), low poloidal beta (..beta../sub p/ < 0.3), naturally large elongation (kappa greater than or equal to 2), large plasma current with I/sub p//(aB/sub t0/) up to about 7 MA/mT, strong paramagnetism (B/sub t//B/sub t0/ > 1.5), and strong plasma helicity (F comparable to THETA). A large near-omnigeneous region is seen at the large-major-radius, bad-curvature region of the plasma in comparison with the conventional tokamaks. These features combine to engender the spherical torus plasma in a unique physics regime which permits compact fusion at low field and modest cost. Because of its strong paramagnetism and helicity, the spherical torus plasma shares some of the desirable features of spheromak and reversed-field pinch (RFP) plasmas, but with tokamak-like confinement and safety factor q. The general class of spherical tori, which includes the spherical tokamak (q > 1), the spherical pinch (1 > q > O), and the spherical RFP (q < O), have magnetic field configurations unique in comparison with conventional tokamaks and RFPs. 22 refs., 12 figs.

  3. ADVANCED HYBRID PARTICULATE COLLECTOR

    SciTech Connect

    Stanley Miller; Rich Gebert; William Swanson

    1999-11-01

    A new concept in particulate control, called an advanced hybrid particulate collector (AHPC), is being developed under funding from the US Department of Energy. The AHPC combines the best features of electrostatic precipitators (ESPs) and baghouses in a manner that has not been done before. The AHPC concept consists of a combination of fabric filtration and electrostatic precipitation in the same housing, providing major synergism between the two collection methods, both in the particulate collection step and in the transfer of dust to the hopper. The AHPC provides ultrahigh collection efficiency, overcoming the problem of excessive fine-particle emission with conventional ESPs, and it solves the problem of reentrainment and collection of dust in conventional baghouses. The AHPC is currently being tested at the 2.7-MW scale at the Big Stone power station.

  4. Advanced laser image recorder.

    PubMed

    Gramenopoulos, N; Hartfield, E D

    1972-12-01

    A laser image recorder is described, which is unique because of its advanced design and the state-of-the-art components employed to achieve high performance and versatility. The critical components are the pyramidal mirror scanner and the beam focusing lens. The scanner has a six-facet, beryllium mirror accurate to 0.33 sec of arc and rotating at 0-50,000 rpm on air bearings. A rapid change in speed is an important feature of this scanner. The focusing lens is diffraction limited with a flat field of 54 degrees , allowing a 90% duty cycle and the use of photographic film transported by a cylindrical drum. The lens converts the constant angular velocity of the reflected beam to a constant scanning velocity of the focused spot with a linearity of 0.05%. Maximum number of picture elements per line is 36,800 over a format of 228.6 mm. PMID:20119408

  5. Recent advances in VECSELs

    NASA Astrophysics Data System (ADS)

    Rahimi-Iman, Arash

    2016-09-01

    Within the last two decades, vertical-external-cavity surface-emitting lasers (VECSELs) have attracted rising interest from both industry and science. They have proven to be versatile lasers which can be specifically designed for research and applications that require a particular regime of operation. Various emission schemes ranging from narrow-linewidth emission, pulsed light or multimode emission to a frequency-converted output are feasible owing to remarkable device features. Being composed of a semiconductor gain mirror and an external cavity, not only is a unique access to high-brightness output and a high-beam quality is provided, but also wavelength flexibility. Moreover, the exploitation of intra-cavity frequency conversion further extends the accessible spectral range from the ultraviolet (UV) to the terahertz (THz). In this work, recent advances in the field of VECSELs are highlighted.

  6. ADVANCED HYBRID PARTICULATE COLLECTOR

    SciTech Connect

    Stanley J. Miller; Grant L. Schelkoph

    1999-04-01

    A new concept in particulate control, called an advanced hybrid particulate collector (AHPC), is being developed under funding from the U.S. Department of Energy. The AHPC combines the best features of electrostatic precipitators (ESPs) and baghouses in a manner that has not been done before. The AHPC concept consists of a combination of fabric filtration and electrostatic precipitation in the same housing, providing major synergism between the two collection methods, both in the particulate collection step and in transfer of the dust to the hopper. The AHPC provides ultrahigh collection efficiency, overcoming the problem of excessive fine-particle emission with conventional ESPs, and it solves the problem of reentrainment and collection of dust in conventional baghouses.

  7. ADVANCED HYBRID PARTICULATE COLLECTOR

    SciTech Connect

    Grant L. Schelkoph; Stanley J. Miller

    1999-07-01

    A new concept in particulate control, called an advanced hybrid particulate collector (AHPC), is being developed under funding from the U.S. Department of Energy. The AHPC combines the best features of electrostatic precipitators (ESPs) and baghouses in a manner that has not been done before. The AHPC concept consists of a combination of fabric filtration and electrostatic precipitation in the same housing, providing major synergism between the two collection methods, both in the particulate collection step and in transfer of the dust to the hopper. The AHPC provides ultrahigh collection efficiency, overcoming the problem of excessive fine-particle emission with conventional ESPs, and it solves the problem of reentrainment and collection of dust in conventional baghouses.

  8. Advances in autism.

    PubMed

    Geschwind, Daniel H

    2009-01-01

    Autism is a common childhood neurodevelopmental disorder with strong genetic liability. It is not a unitary entity but a clinical syndrome, with variable deficits in social behavior and language, restrictive interests, and repetitive behaviors. Recent advances in the genetics of autism emphasize its etiological heterogeneity, with each genetic susceptibility locus accounting for only a small fraction of cases or having a small effect. Therefore, it is not surprising that no unifying structural or neuropathological features have been conclusively identified. Given the heterogeneity of autism spectrum disorder (ASD), approaches based on studying heritable components of the disorder, or endophenotypes, such as language or social cognition, provide promising avenues for genetic and neurobiological investigations. Early intensive behavioral and cognitive interventions are efficacious in many cases, but autism does not remit in the majority of children. Therefore, development of targeted therapies based on pathophysiologically and etiologically defined subtypes of ASD remains an important and achievable goal of current research. PMID:19630577

  9. Special Feature: Facilities.

    ERIC Educational Resources Information Center

    Storm, George; And Others

    1993-01-01

    Includes "Planning Laboratory Design" (Storm); "Perkins Money for Automotive Programs" (Cash); "Stretching a Budget" (Warren); "Video Teleconferencing--Powerful Communication for Occupational Educators" (Major); "Danger: Hazardous Materials" (Brown); and "Keeping Facilities Safe--Electrical Safety and Maintenance" (Kirk). (JOW)

  10. The acoustic features of human laughter

    NASA Astrophysics Data System (ADS)

    Bachorowski, Jo-Anne; Owren, Michael J.

    2002-05-01

    Remarkably little is known about the acoustic features of laughter, despite laughter's ubiquitous role in human vocal communication. Outcomes are described for 1024 naturally produced laugh bouts recorded from 97 young adults. Acoustic analysis focused on temporal characteristics, production modes, source- and filter-related effects, and indexical cues to laugher sex and individual identity. The results indicate that laughter is a remarkably complex vocal signal, with evident diversity in both production modes and fundamental frequency characteristics. Also of interest was finding a consistent lack of articulation effects in supralaryngeal filtering. Outcomes are compared to previously advanced hypotheses and conjectures about this species-typical vocal signal.

  11. Advanced stellarators

    NASA Astrophysics Data System (ADS)

    Schlüter, Arnulf

    1983-03-01

    Toroidal confinement of a plasma by an external magnetic field is not compatible with axisymmetry, in contrast to confinement by the pinch effect of induced electric currents as in a tokomak or by the reversed field pinch configuration. The existence of magnetic surfaces throughout the region in which grad p ≠ 0 is therefore not guaranteed in such configurations, though it is necessary for MHD-equilibrium when the lines of force possess a finite twist (or "rotational transform"). These twisted equilibria are called stellarators. The other type of external confinement requires all lines of force to be closed upon themselves and p to be function of the well defined quantity Q = φ d l/ B only. The resulting "bumpy" tori are sometimes also referred to as being M + S like. By discussing specific examples it is shown that stellarator configurations exist which retain as much as possible the properties of M + S like configurations, combine these with the magnetic well, and with an approximation to the isodynamic requirement of D. Palumbo. These so-called Advanced Stellarators shown an improvement in predicted particle confinement and beta-limit compared to the classical stellarators. They can also be viewed as forming a system of linked stabilized mirrors of small mirror ratio. These fields can be produced by modular coils. A prototype of such a configuration is being designed by the stellarator division of IPP under the name of Wendelstein VII-AS. Expected physical data and technical details of W VII-AS are given.

  12. Advanced capacitors

    NASA Astrophysics Data System (ADS)

    Parker, R. D.; Buritz, R. S.; Taylor, A. R.; Bullwinkel, E. P.

    1982-11-01

    An experimental development program was conducted to develop and test advanced dielectric materials for capacitors for airborne power systems. High rep rate and low rate capacitors for use in pulse-forming networks, high voltage filter capacitors, and high frequency ac capacitors for series resonant inverters were considered. The initial goal was to develop an improved polysulfone film. Initially, low breakdown strength was thought to be related to inclusions of conductive particles. The effect of filtration of the casting solution was investigated. These experiments showed that more filtration was not the entire solution to low breakdown. The film samples were found to contain dissolved ionic impurities that move through the dielectric when voltage is applied and cause enhancement of the electric field. These contaminants enter the film via the resin and solvent, and can be partially removed. However, these treatments did not significantly improve the breakdown characteristics. A new material, Ultem, was proposed for use in high energy density capacitors. This new polyetherimide resin has properties similar to polysulfone and polyimide, with improvement in breakdown characteristics and temperature capability. The technique of casting films on a roughened drum was demonstrated, and found useful in preparing textured films. this is the first step toward a replacement for kraft paper.

  13. Advanced capacitors

    NASA Astrophysics Data System (ADS)

    Ennis, J. B.; Buritz, R. S.

    1984-10-01

    This report describes an experimental program to develop and test advanced dielectric materials for capacitors for airborne power systems. Five classes of capacitors were considered: high rep rate and low rep rate pulse capacitors for use in pulse-forming networks, high voltage filter capacitors, high frequency AC capacitors for series resonant inverters, and AC filter capacitors. To meet these requirements, existing dielectric materials were modified, and new materials were developed. The initial goal was to develop an improved polysulfone film with fewer imperfections that could operate at significantly higher electrical stresses. It was shown that contaminants enter the film via the resin and solvent, and that they can be partially removed. As far as developed, however, these treatments did not significantly improved the breakdown characteristics. The technique of casting films on a roughened drum was demonstrated, and found useful in preparing textured films -- the first step toward a replacement for Kraft paper. A new material, Ultem, was proposed for use in high energy density capacitors. This new polyetherimide resin has properties similar to polysulfone and polyimide, with improvement in breakdown characteristics and temperature capability. This material was selected for further study in model capacitor designs.

  14. Advanced Beamline Design for Fermilab's Advanced Superconducting Test Accelerator

    SciTech Connect

    Prokop, Christopher

    2014-01-01

    The Advanced Superconducting Test Accelerator (ASTA) at Fermilab is a new electron accelerator currently in the commissioning stage. In addition to testing superconducting accelerating cavities for future accelerators, it is foreseen to support a variety of Advanced Accelerator R&D (AARD) experiments. Producing the required electron bunches with the expected flexibility is challenging. The goal of this dissertation is to explore via numerical simulations new accelerator beamlines that can enable the advanced manipulation of electron bunches. The work especially includes the design of a low-energy bunch compressor and a study of transverse-to-longitudinal phase space exchangers.

  15. Advanced beamline design for Fermilab's Advanced Superconducting Test Accelerator

    NASA Astrophysics Data System (ADS)

    Prokop, Christopher R.

    The Advanced Superconducting Test Accelerator (ASTA) at Fermilab is a new electron accelerator currently in the commissioning stage. In addition to testing superconducting accelerating cavities for future accelerators, it is foreseen to support a variety of Advanced Accelerator R&D (AARD) experiments. Producing the required electron bunches with the expected flexibility is challenging. The goal of this dissertation is to explore via numerical simulations new accelerator beamlines that can enable the advanced manipulation of electron bunches. The work especially includes the design of a low-energy bunch compressor and a study of transverse-to-longitudinal phase space exchangers.

  16. A prototype feature system for feature retrieval using relationships

    USGS Publications Warehouse

    Choi, J.; Usery, E.L.

    2009-01-01

    Using a feature data model, geographic phenomena can be represented effectively by integrating space, theme, and time. This paper extends and implements a feature data model that supports query and visualization of geographic features using their non-spatial and temporal relationships. A prototype feature-oriented geographic information system (FOGIS) is then developed and storage of features named Feature Database is designed. Buildings from the U.S. Marine Corps Base, Camp Lejeune, North Carolina and subways in Chicago, Illinois are used to test the developed system. The results of the applications show the strength of the feature data model and the developed system 'FOGIS' when they utilize non-spatial and temporal relationships in order to retrieve and visualize individual features.

  17. Constructing and validating readability models: the method of integrating multilevel linguistic features with machine learning.

    PubMed

    Sung, Yao-Ting; Chen, Ju-Ling; Cha, Ji-Her; Tseng, Hou-Chiang; Chang, Tao-Hsing; Chang, Kuo-En

    2015-06-01

    Multilevel linguistic features have been proposed for discourse analysis, but there have been few applications of multilevel linguistic features to readability models and also few validations of such models. Most traditional readability formulae are based on generalized linear models (GLMs; e.g., discriminant analysis and multiple regression), but these models have to comply with certain statistical assumptions about data properties and include all of the data in formulae construction without pruning the outliers in advance. The use of such readability formulae tends to produce a low text classification accuracy, while using a support vector machine (SVM) in machine learning can enhance the classification outcome. The present study constructed readability models by integrating multilevel linguistic features with SVM, which is more appropriate for text classification. Taking the Chinese language as an example, this study developed 31 linguistic features as the predicting variables at the word, semantic, syntax, and cohesion levels, with grade levels of texts as the criterion variable. The study compared four types of readability models by integrating unilevel and multilevel linguistic features with GLMs and an SVM. The results indicate that adopting a multilevel approach in readability analysis provides a better representation of the complexities of both texts and the reading comprehension process.

  18. Drug/nondrug classification using Support Vector Machines with various feature selection strategies.

    PubMed

    Korkmaz, Selcuk; Zararsiz, Gokmen; Goksuluk, Dincer

    2014-11-01

    In conjunction with the advance in computer technology, virtual screening of small molecules has been started to use in drug discovery. Since there are thousands of compounds in early-phase of drug discovery, a fast classification method, which can distinguish between active and inactive molecules, can be used for screening large compound collections. In this study, we used Support Vector Machines (SVM) for this type of classification task. SVM is a powerful classification tool that is becoming increasingly popular in various machine-learning applications. The data sets consist of 631 compounds for training set and 216 compounds for a separate test set. In data pre-processing step, the Pearson's correlation coefficient used as a filter to eliminate redundant features. After application of the correlation filter, a single SVM has been applied to this reduced data set. Moreover, we have investigated the performance of SVM with different feature selection strategies, including SVM-Recursive Feature Elimination, Wrapper Method and Subset Selection. All feature selection methods generally represent better performance than a single SVM while Subset Selection outperforms other feature selection methods. We have tested SVM as a classification tool in a real-life drug discovery problem and our results revealed that it could be a useful method for classification task in early-phase of drug discovery. PMID:25224081

  19. Recent advances in understanding schizophrenia

    PubMed Central

    Haller, Chiara S.; Padmanabhan, Jaya L.; Lizano, Paulo; Torous, John

    2014-01-01

    Schizophrenia is a highly disabling disorder whose causes remain to be better understood, and treatments have to be improved. However, several recent advances have been made in diagnosis, etiopathology, and treatment. Whereas reliability of diagnosis has improved with operational criteria, including Diagnostic and Statistical Manual of Mental Disorders, (DSM) Fifth Edition, validity of the disease boundaries remains unclear because of substantive overlaps with other psychotic disorders. Recent emphasis on dimensional approaches and translational bio-behavioral research domain criteria may eventually help move toward a neuroscience-based definition of schizophrenia. The etiology of schizophrenia is now thought to be multifactorial, with multiple small-effect and fewer large-effect susceptibility genes interacting with several environmental factors. These factors may lead to developmentally mediated alterations in neuroplasticity, manifesting in a cascade of neurotransmitter and circuit dysfunctions and impaired connectivity with an onset around early adolescence. Such etiopathological understanding has motivated a renewed search for novel pharmacological as well as psychotherapeutic targets. Addressing the core features of the illness, such as cognitive deficits and negative symptoms, and developing hypothesis-driven early interventions and preventive strategies are high-priority goals for the field. Schizophrenia is a severe, chronic mental disorder and is among the most disabling disorders in all of medicine. It is estimated by the National Institute of Mental Health (NIMH) that 2.4 million people over the age of 18 in the US suffer from schizophrenia. This illness typically begins in adolescence and derails the formative goals of school, family, and work, leading to considerable suffering and disability and reduced life expectancy by about 20 years. Treatment outcomes are variable, and some people are successfully treated and reintegrated (i.e. go back to work

  20. Intelligent Engine Systems: Thermal Management and Advanced Cooling

    NASA Technical Reports Server (NTRS)

    Bergholz, Robert

    2008-01-01

    The objective of the Advanced Turbine Cooling and Thermal Management program is to develop intelligent control and distribution methods for turbine cooling, while achieving a reduction in total cooling flow and assuring acceptable turbine component safety and reliability. The program also will develop embedded sensor technologies and cooling system models for real-time engine diagnostics and health management. Both active and passive control strategies will be investigated that include the capability of intelligent modulation of flow quantities, pressures, and temperatures both within the supply system and at the turbine component level. Thermal management system concepts were studied, with a goal of reducing HPT blade cooling air supply temperature. An assessment will be made of the use of this air by the active clearance control system as well. Turbine component cooling designs incorporating advanced, high-effectiveness cooling features, will be evaluated. Turbine cooling flow control concepts will be studied at the cooling system level and the component level. Specific cooling features or sub-elements of an advanced HPT blade cooling design will be downselected for core fabrication and casting demonstrations.

  1. Approximately Independent Features of Languages

    NASA Astrophysics Data System (ADS)

    Holman, Eric W.

    To facilitate the testing of models for the evolution of languages, the present paper offers a set of linguistic features that are approximately independent of each other. To find these features, the adjusted Rand index (R‧) is used to estimate the degree of pairwise relationship among 130 linguistic features in a large published database. Many of the R‧ values prove to be near zero, as predicted for independent features, and a subset of 47 features is found with an average R‧ of -0.0001. These 47 features are recommended for use in statistical tests that require independent units of analysis.

  2. Advanced Space Propulsion

    NASA Technical Reports Server (NTRS)

    Frisbee, Robert H.

    1996-01-01

    system with a low initial development and infrastructure cost and a high operating cost. Note however that this has resulted in a 'Catch 22' standoff between the need for large initial investment that is amortized over many launches to reduce costs, and the limited number of launches possible at today's launch costs. Some examples of missions enabled (either in cost or capability) by advanced propulsion include long-life station-keeping or micro-spacecraft applications using electric propulsion or BMDO-derived micro-thrusters, low-cost orbit raising (LEO to GEO or Lunar orbit) using electric propulsion, robotic planetary missions using aerobraking or electric propulsion, piloted Mars missions using aerobraking and/or propellant production from Martian resources, very fast (100-day round-trip) piloted Mars missions using fission or fusion propulsion, and, finally, interstellar missions using fusion, antimatter, or beamed energy. The NASA Advanced Propulsion Technology program at the Jet Propulsion Laboratory (JPL) is aimed at assessing the feasibility of a range of near-term to far term advanced propulsion technologies that have the potential to reduce costs and/or enable future space activities. The program includes cooperative modeling and research activities between JPL and various universities and industry; and directly supported independent research at universities and industry. The cooperative program consists of mission studies, research and development of ion engine technology using C60 (Buckminsterfullerene) propellant, and research and development of lithium-propellant Lorentz-force accelerator (LFA) engine technology. The university/industry-supported research includes modeling and proof-of-concept experiments in advanced, high-lsp, long-life electric propulsion, and in fusion propulsion.

  3. SECOND GENERATION ADVANCED REBURNING FOR HIGH EFFICIENCY NOx CONTROL

    SciTech Connect

    Vladimir M. Zamansky; Peter M. Maly; Vitali V. Lissianski

    1999-10-29

    This project is designed to develop a family of novel NO{sub x} control technologies, called Second Generation Advanced Reburning which has the potential to achieve 90+ NO{sub x} control in coal fired boilers at a significantly lower cost than Selective Catalytic Reduction. The eighth reporting period in Phase II (July 1--September 26, 1999) included combined chemistry-mixing modeling on advanced gas reburning and experimental activities in support of modeling. Modeling efforts focused on description of AR-Lean--combination of basic reburning and co-injection of N-agent with overfire air. Modeling suggests that efficiency of AR-Lean strongly depends on the amount of the reburning fuel, temperature of flue gas at the point of OFA/N-agent injection, and evaporation time of N-agent. The model describes the most important features of AR-Lean and can be used for AR-Lean optimization.

  4. Technology requirements for advanced earth-orbital transportation systems

    NASA Technical Reports Server (NTRS)

    Haefeli, R. C.; Littler, E. G.; Hurley, J. B.; Winter, M. G.

    1977-01-01

    Areas of advanced technology that are either critical or offer significant benefits to the development of future Earth-orbit transportation systems were identified. Technology assessment was based on the application of these technologies to fully reusable, single-stage-to-orbit (SSTO) vehicle concepts with horizontal landing capability. Study guidelines included mission requirements similar to space shuttle, an operational capability begining in 1995, and main propulsion to be advanced hydrogen-fueled rocket engines. Also evaluated was the technical and economic feasibility of this class of SSTO concepts and the comparative features of three operational take-off modes, which were vertical boost, horizontal sled launch, and horizontal take-off with subsequent inflight fueling. Projections of both normal and accelerated technology growth were made. Figures of merit were derived to provide relative rankings of technology areas. The influence of selected accelerated areas on vehicle design and program costs was analyzed by developing near-optimum point designs.

  5. Energy and Economic Trade Offs for Advanced Technology Subsonic Aircraft

    NASA Technical Reports Server (NTRS)

    Maddalon, D. V.; Wagner, R. D.

    1976-01-01

    Changes in future aircraft technology which conserve energy are studied, along with the effect of these changes on economic performance. Among the new technologies considered are laminar-flow control, composite materials with and without laminar-flow control, and advanced airfoils. Aircraft design features studied include high-aspect-ratio wings, thickness ratio, and range. Engine technology is held constant at the JT9D level. It is concluded that wing aspect ratios of future aircraft are likely to significantly increase as a result of new technology and the push of higher fuel prices. Composite materials may raise aspect radio to about 11 to 12 and practical laminar flow-control systems may further increase aspect ratio to 14 or more. Advanced technology provides significant reductions in aircraft take-off gross weight, energy consumption, and direct operating cost.

  6. Elements of an advanced integrated operator control station

    SciTech Connect

    Clarke, M.M.; Kreifeldt, J.G.

    1984-01-01

    One of the critical determinants of peformance for any remotely operated maintenance system is the compatibility achieved between elements of the man/machine interface (e.g., master manipulator controller, controls, displays, etc.) and the human operator. In the Remote Control Engineering task of the Consolidated Fuel Reprocessing Program, considerable attention has been devoted to optimizing the man/machine interface of the operator control station. This system must be considered an integral element of the overall maintenance work system which includes transporters, manipulators, remote viewing, and other parts. The control station must reflect the integration of the operator team, control/display panels, manipulator master controllers, and remote viewing monitors. Human factors principles and experimentation have been used in the development of an advanced integrated operator control station designed for the advance servomanipulator. Key features of this next-generation design are summarized in this presentation. 7 references, 4 figures.

  7. Elements of an advanced integrated operator control station

    SciTech Connect

    Clarke, M.M.; Kreifeldt, J.G.

    1984-01-01

    One of the critical determinants of performance for any remotely operated maintenance system is the compatibility achieved between elements of the man/machine interface (e.g., master manipulator controller, controls, displays) and the human operator. In the remote control engineering task of the Consolidated Fuel Reprocessing Program, considerable attention has been devoted to optimizing the man/machine interface of the operator control station. This system must be considered an integral element of the overall maintenance work system which includes transporters, manipulators, remote viewing, and other parts. The control station must reflect the integration of the operator team, control/display panels, manipulator master controllers, and remote viewing monitors. Human factors principles and experimentation have been used in the development of an advanced integrated operator control station designed for the advance servomanipulator. Key features of this next-generation design are summarized in this presentation. 7 references, 4 figures.

  8. Whole-genome CNV analysis: advances in computational approaches

    PubMed Central

    Pirooznia, Mehdi; Goes, Fernando S.; Zandi, Peter P.

    2015-01-01

    Accumulating evidence indicates that DNA copy number variation (CNV) is likely to make a significant contribution to human diversity and also play an important role in disease susceptibility. Recent advances in genome sequencing technologies have enabled the characterization of a variety of genomic features, including CNVs. This has led to the development of several bioinformatics approaches to detect CNVs from next-generation sequencing data. Here, we review recent advances in CNV detection from whole genome sequencing. We discuss the informatics approaches and current computational tools that have been developed as well as their strengths and limitations. This review will assist researchers and analysts in choosing the most suitable tools for CNV analysis as well as provide suggestions for new directions in future development. PMID:25918519

  9. Fracture Toughness in Advanced Monolithic Ceramics - SEPB Versus SEVENB Methods

    NASA Technical Reports Server (NTRS)

    Choi, S. R.; Gyekenyesi, J. P.

    2005-01-01

    Fracture toughness of a total of 13 advanced monolithic ceramics including silicon nitrides, silicon carbide, aluminas, and glass ceramic was determined at ambient temperature by using both single edge precracked beam (SEPB) and single edge v-notched beam (SEVNB) methods. Relatively good agreement in fracture toughness between the two methods was observed for advanced ceramics with flat R-curves; whereas, poor agreement in fracture toughness was seen for materials with rising R-curves. The discrepancy in fracture toughness between the two methods was due to stable crack growth with crack closure forces acting in the wake region of cracks even in SEVNB test specimens. The effect of discrepancy in fracture toughness was analyzed in terms of microstructural feature (grain size and shape), toughening exponent, and stable crack growth determined using back-face strain gaging.

  10. Feature Selection via Chaotic Antlion Optimization

    PubMed Central

    Zawbaa, Hossam M.; Emary, E.; Grosan, Crina

    2016-01-01

    Background Selecting a subset of relevant properties from a large set of features that describe a dataset is a challenging machine learning task. In biology, for instance, the advances in the available technologies enable the generation of a very large number of biomarkers that describe the data. Choosing the more informative markers along with performing a high-accuracy classification over the data can be a daunting task, particularly if the data are high dimensional. An often adopted approach is to formulate the feature selection problem as a biobjective optimization problem, with the aim of maximizing the performance of the data analysis model (the quality of the data training fitting) while minimizing the number of features used. Results We propose an optimization approach for the feature selection problem that considers a “chaotic” version of the antlion optimizer method, a nature-inspired algorithm that mimics the hunting mechanism of antlions in nature. The balance between exploration of the search space and exploitation of the best solutions is a challenge in multi-objective optimization. The exploration/exploitation rate is controlled by the parameter I that limits the random walk range of the ants/prey. This variable is increased iteratively in a quasi-linear manner to decrease the exploration rate as the optimization progresses. The quasi-linear decrease in the variable I may lead to immature convergence in some cases and trapping in local minima in other cases. The chaotic system proposed here attempts to improve the tradeoff between exploration and exploitation. The methodology is evaluated using different chaotic maps on a number of feature selection datasets. To ensure generality, we used ten biological datasets, but we also used other types of data from various sources. The results are compared with the particle swarm optimizer and with genetic algorithm variants for feature selection using a set of quality metrics. PMID:26963715

  11. Neuroimaging of pediatric brain tumors: from basic to advanced magnetic resonance imaging (MRI).

    PubMed

    Panigrahy, Ashok; Blüml, Stefan

    2009-11-01

    In this review, the basic magnetic resonance concepts used in the imaging approach of a pediatric brain tumor are described with respect to different factors including understanding the significance of the patient's age. Also discussed are other factors directly related to the magnetic resonance scan itself including evaluating the location of the tumor, determining if the lesion is extra-axial or intra-axial, and evaluating the contrast characteristics of the lesion. Of note, there are key imaging features of pediatric brain tumors, which can give information about the cellularity of the lesion, which can then be confirmed with advanced magnetic resonance imaging (MRI) techniques. The second part of this review will provide an overview of the major advanced MRI techniques used in pediatric imaging, particularly, magnetic resonance diffusion, magnetic resonance spectroscopy, and magnetic resonance perfusion. The last part of the review will provide more specific information about the use of advanced magnetic resonance techniques in the evaluation of pediatric brain tumors.

  12. Advanced-technology space station study: Summary of systems and pacing technologies

    NASA Technical Reports Server (NTRS)

    Butterfield, A. J.; Garn, P. A.; King, C. B.; Queijo, M. J.

    1990-01-01

    The principal system features defined for the Advanced Technology Space Station are summarized and the 21 pacing technologies identified during the course of the study are described. The descriptions of system configurations were extracted from four previous study reports. The technological areas focus on those systems particular to all large spacecraft which generate artificial gravity by rotation. The summary includes a listing of the functions, crew requirements and electrical power demand that led to the studied configuration. The pacing technologies include the benefits of advanced materials, in-orbit assembly requirements, stationkeeping, evaluations of electrical power generation alternates, and life support systems. The descriptions of systems show the potential for synergies and identifies the beneficial interactions that can result from technological advances.

  13. Advanced composites technology

    SciTech Connect

    DeTeresa, S J; Groves, S E; Sanchez, R J

    1998-10-01

    The development of fiber composite components in next-generation munitions, such as sabots for kinetic energy penetrators and lightweight cases for advanced artillery projectiles, relies on design trade-off studies using validated computer code simulations. We are developing capabilities to determine the failure of advanced fiber composites under multiaxial stresses to critically evaluate three-dimensional failure models and develop new ones if necessary. The effects of superimposed hydrostatic pressure on failure of composites are being investigated using a high-pressure testing system that incorporates several unique features. Several improvements were made to the system this year, and we report on the first tests of both isotropic and fiber composite materials. The preliminary results indicate that pressure has little effect on longitudinal compression strength of unidirectional composites, but issues with obtaining reliable failures in these materials still remain to be resolved. The transverse compression strength was found to be significantly enhanced by pressure, and the trends observed for this property and the longitudinal strength are in agreement with recent models for failure of fiber composites.

  14. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project. ACT/Control/Guidance System study. Volume 2: Appendices

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The integrated application of active controls (IAAC) technology to an advanced subsonic transport is reported. Supplementary technical data on the following topics are included: (1) 1990's avionics technology assessment; (2) function criticality assessment; (3) flight deck system for total control and functional features list; (4) criticality and reliability assessment of units; (5) crew procedural function task analysis; and (6) recommendations for simulation mechanization.

  15. Feature selection for physics model based object discrimination

    NASA Astrophysics Data System (ADS)

    Wang, Chunmei; Collins, Leslie

    2005-06-01

    We investigated the application of two state-of-the-art feature selection algorithms for subsurface target discrimination. One is called joint classification and feature optimization (JCFO), which imposes a sparse prior on the features, and optimizes the classifier and its predictors simultaneously via an expectation maximization (EM) algorithm. The other selects features by directly maximizing the hypothesis margin between targets and clutter. The results of feature selection and target discrimination are demonstrated using wideband electromagnetic induction data measured at data collected at the Aberdeen Proving Ground Standardized Test Site for UXO discrimination. It is shown that the classification performance is significantly improved by only including a compact set of relevant features.

  16. Advanced life support study

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Summary reports on each of the eight tasks undertaken by this contract are given. Discussed here is an evaluation of a Closed Ecological Life Support System (CELSS), including modeling and analysis of Physical/Chemical Closed Loop Life Support (P/C CLLS); the Environmental Control and Life Support Systems (ECLSS) evolution - Intermodule Ventilation study; advanced technologies interface requirements relative to ECLSS; an ECLSS resupply analysis; the ECLSS module addition relocation systems engineering analysis; an ECLSS cost/benefit analysis to identify rack-level interface requirements of the alternate technologies evaluated in the ventilation study, with a comparison of these with the rack level interface requirements for the baseline technologies; advanced instrumentation - technology database enhancement; and a clean room survey and assessment of various ECLSS evaluation options for different growth scenarios.

  17. Advanced Technology Vehicle Testing

    SciTech Connect

    James Francfort

    2004-06-01

    The goal of the U.S. Department of Energy's Advanced Vehicle Testing Activity (AVTA) is to increase the body of knowledge as well as the awareness and acceptance of electric drive and other advanced technology vehicles (ATV). The AVTA accomplishes this goal by testing ATVs on test tracks and dynamometers (Baseline Performance testing), as well as in real-world applications (Fleet and Accelerated Reliability testing and public demonstrations). This enables the AVTA to provide Federal and private fleet managers, as well as other potential ATV users, with accurate and unbiased information on vehicle performance and infrastructure needs so they can make informed decisions about acquiring and operating ATVs. The ATVs currently in testing include vehicles that burn gaseous hydrogen (H2) fuel and hydrogen/CNG (H/CNG) blended fuels in internal combustion engines (ICE), and hybrid electric (HEV), urban electric, and neighborhood electric vehicles. The AVTA is part of DOE's FreedomCAR and Vehicle Technologies Program.

  18. Recent Advances in Voltammetry

    PubMed Central

    Batchelor-McAuley, Christopher; Kätelhön, Enno; Barnes, Edward O; Compton, Richard G; Laborda, Eduardo; Molina, Angela

    2015-01-01

    Recent progress in the theory and practice of voltammetry is surveyed and evaluated. The transformation over the last decade of the level of modelling and simulation of experiments has realised major advances such that electrochemical techniques can be fully developed and applied to real chemical problems of distinct complexity. This review focuses on the topic areas of: multistep electrochemical processes, voltammetry in ionic liquids, the development and interpretation of theories of electron transfer (Butler–Volmer and Marcus–Hush), advances in voltammetric pulse techniques, stochastic random walk models of diffusion, the influence of migration under conditions of low support, voltammetry at rough and porous electrodes, and nanoparticle electrochemistry. The review of the latter field encompasses both the study of nanoparticle-modified electrodes, including stripping voltammetry and the new technique of ‘nano-impacts’. PMID:26246984

  19. Recent Advances in Voltammetry.

    PubMed

    Batchelor-McAuley, Christopher; Kätelhön, Enno; Barnes, Edward O; Compton, Richard G; Laborda, Eduardo; Molina, Angela

    2015-06-01

    Recent progress in the theory and practice of voltammetry is surveyed and evaluated. The transformation over the last decade of the level of modelling and simulation of experiments has realised major advances such that electrochemical techniques can be fully developed and applied to real chemical problems of distinct complexity. This review focuses on the topic areas of: multistep electrochemical processes, voltammetry in ionic liquids, the development and interpretation of theories of electron transfer (Butler-Volmer and Marcus-Hush), advances in voltammetric pulse techniques, stochastic random walk models of diffusion, the influence of migration under conditions of low support, voltammetry at rough and porous electrodes, and nanoparticle electrochemistry. The review of the latter field encompasses both the study of nanoparticle-modified electrodes, including stripping voltammetry and the new technique of 'nano-impacts'. PMID:26246984

  20. Advanced Planning.

    ERIC Educational Resources Information Center

    Lupinacci, Jeffrey A.

    2000-01-01

    Explains the importance of developing a comprehensive security plan prior to purchasing more equipment and resources to bolster school safety. Decision making following the plan's development is addressed including equipment choices, ID cards, access control, exit alarms, and video monitors. (GR)

  1. Data management system advanced architectures

    NASA Technical Reports Server (NTRS)

    Chevers, ED

    1991-01-01

    The topics relating to the Space Station Freedom (SSF) are presented in view graph form and include: (1) the data management system (DMS) concept; (2) DMS evolution rationale; (3) the DMS advance architecture task; (4) DMS group support for Ames payloads; (5) DMS testbed development; (6) the DMS architecture task status; (7) real time multiprocessor testbed; (8) networked processor performance; (9) and the DMS advance architecture task 1992 goals.

  2. Advanced Gradient Heating Facility (AGHF)

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This section of the publication includes papers entitled: (1) Coupled growth in hypermonotectics; (2) Directional solidification of refined Al-4 wt.% Cu alloys; (3) Effects of convection on interface curvature during growth of concentrated ternary compounds; (4) Directional solidification of Al-1.5 wt.% Ni alloys; (5) Interactive response of advancing phase boundaries to particles; (6) INTeractive Response of Advancing Phase boundaries to Particles-INTRAPP; and (7) Particle engulfment and pushing by solidifying interfaces.

  3. Genetic Features of Turner Syndrome

    MedlinePlus

    ... Current Studies Publications Lab Staff Contact Info Links Genetic Features Quick Navigation Introduction X-monosomy X-mosaicism ... Figure 3. X Chromosome Abnormalities Figure 4. Mosaicism Genetic Features of Turner Syndrome Turner syndrome is a ...

  4. Featuring the South Pacific.

    ERIC Educational Resources Information Center

    Hagan, Brian Terrence; And Others

    1996-01-01

    This thematic section includes "Community Education in the Cook Islands" (Brian Terrence Hagan); "Developing the Grassroots: A Community Education Program in Fiji" (Joseph Veramu); "Literacy in the Community: The Papua New Guinea Experience" (Vincent Manukayasi); "Young Aborigine People Learn about Life through Comic Books"; and "A New and…

  5. Feature: Special Needs.

    ERIC Educational Resources Information Center

    Flores, Miguel R.; And Others

    1993-01-01

    Includes "Filling in the Cracks" (Flores) about an intarsia class for at-risk students; "Closing the Gap--Women in Technology" (Husher) about summer camps for junior high girls; "Work Force of the Future--Multi-Ethnic, Multicultural" (Hall) about vocational education for culturally diverse students; "Collaboration Comes to the Vocational…

  6. Further evidence for feature correlations in semantic memory.

    PubMed

    McRae, K; Cree, G S; Westmacott, R; de Sa, V R

    1999-12-01

    The role of feature correlations in semantic memory is a central issue in conceptual representation. In two versions of the feature verification task, participants were faster to verify that a feature (< is juicy >) is part of a concept (grapefruit) if it is strongly rather than weakly intercorrelated with the other features of that concept. Contrasting interactions between feature correlations and SOA were found when the concept versus the feature was presented first. An attractor network model of word meaning that naturally learns and uses feature correlations predicted those interactions. This research provides further evidence that semantic memory includes implicitly learned statistical knowledge of feature relationships, in contrast to theories such as spreading activation networks, in which feature correlations play no role.

  7. Image feature localization by multiple hypothesis testing of Gabor features.

    PubMed

    Ilonen, Jarmo; Kamarainen, Joni-Kristian; Paalanen, Pekka; Hamouz, Miroslav; Kittler, Josef; Kälviäinen, Heikki

    2008-03-01

    Several novel and particularly successful object and object category detection and recognition methods based on image features, local descriptions of object appearance, have recently been proposed. The methods are based on a localization of image features and a spatial constellation search over the localized features. The accuracy and reliability of the methods depend on the success of both tasks: image feature localization and spatial constellation model search. In this paper, we present an improved algorithm for image feature localization. The method is based on complex-valued multi resolution Gabor features and their ranking using multiple hypothesis testing. The algorithm provides very accurate local image features over arbitrary scale and rotation. We discuss in detail issues such as selection of filter parameters, confidence measure, and the magnitude versus complex representation, and show on a large test sample how these influence the performance. The versatility and accuracy of the method is demonstrated on two profoundly different challenging problems (faces and license plates).

  8. Recent advances in flexible low power cholesteric LCDs

    NASA Astrophysics Data System (ADS)

    Khan, Asad; Shiyanovskaya, Irina; Montbach, Erica; Schneider, Tod; Nicholson, Forrest; Miller, Nick; Marhefka, Duane; Ernst, Todd; Doane, J. W.

    2006-05-01

    Bistable reflective cholesteric displays are a liquid crystal display technology developed to fill a market need for very low power displays. Their unique look, high reflectivity, bistability, and simple structure make them an ideal flat panel display choice for handheld or other portable devices where small lightweight batteries with long lifetimes are important. Applications ranging from low resolution large signs to ultra high resolution electronic books can utilize cholesteric displays to not only benefit from the numerous features, but also create enabling features that other flat panel display technologies cannot. Flexible displays are the focus of attention of numerous research groups and corporations worldwide. Cholesteric displays have been demonstrated to be highly amenable to flexible substrates. This paper will review recent advances in flexible cholesteric displays including both phase separation and emulsification approaches to encapsulation. Both approaches provide unique benefits to various aspects of manufacturability, processes, flexibility, and conformability.

  9. Advanced rotorcraft transmission program

    NASA Technical Reports Server (NTRS)

    Bill, Robert C.

    1990-01-01

    The Advanced Rotorcraft Transmission (ART) program is an Army-funded, joint Army/NASA program to develop and demonstrate lightweight, quiet, durable drivetrain systems for next generation rotorcraft. ART addresses the drivetrain requirements of two distinct next generation aircraft classes: Future Air Attack Vehicle, a 10,000 to 20,000 lb. aircraft capable of undertaking tactical support and air-to-air missions; and Advanced Cargo Aircraft, a 60,000 to 80,000 lb. aircraft capable of heavy life field support operations. Both tiltrotor and more conventional helicopter configurations are included in the ART program. Specific objectives of ART include reduction of drivetrain weight by 25 percent compared to baseline state-of-the-art drive systems configured and sized for the next generation aircraft, reduction of noise level at the transmission source by 10 dB relative to a suitably sized and configured baseline, and attainment of at least a 5000 hr mean-time-between-removal. The technical approach for achieving the ART goals includes application of the latest available component, material, and lubrication technology to advanced concept drivetrains that utilize new ideas in gear configuration, transmission layout, and airframe/drivetrain integration. To date, candidate drivetrain systems were carried to a conceptual design stage, and tradeoff studies were conducted resulting in selection of an ART transmission configuration for each of the four contractors. The final selection was based on comparative weight, noise, and reliability studies. A description of each of the selected ART designs is included. Preliminary design of each of the four selected ART transmission was completed, as have mission impact studies wherein comparisons of aircraft mission performance and life cycle costs are undertaken for the next generation aircraft with ART and with the baseline transmission.

  10. Advanced composite fuselage technology

    NASA Technical Reports Server (NTRS)

    Ilcewicz, Larry B.; Smith, Peter J.; Horton, Ray E.

    1993-01-01

    Boeing's ATCAS program has completed its third year and continues to progress towards a goal to demonstrate composite fuselage technology with cost and weight advantages over aluminum. Work on this program is performed by an integrated team that includes several groups within The Boeing Company, industrial and university subcontractors, and technical support from NASA. During the course of the program, the ATCAS team has continued to perform a critical review of composite developments by recognizing advances in metal fuselage technology. Despite recent material, structural design, and manufacturing advancements for metals, polymeric matrix composite designs studied in ATCAS still project significant cost and weight advantages for future applications. A critical path to demonstrating technology readiness for composite transport fuselage structures was created to summarize ATCAS tasks for Phases A, B, and C. This includes a global schedule and list of technical issues which will be addressed throughout the course of studies. Work performed in ATCAS since the last ACT conference is also summarized. Most activities relate to crown quadrant manufacturing scaleup and performance verification. The former was highlighted by fabricating a curved, 7 ft. by 10 ft. panel, with cocured hat-stiffeners and cobonded J-frames. In building to this scale, process developments were achieved for tow-placed skins, drape formed stiffeners, braided/RTM frames, and panel cure tooling. Over 700 tests and supporting analyses have been performed for crown material and design evaluation, including structural tests that demonstrated limit load requirements for severed stiffener/skin failsafe damage conditions. Analysis of tests for tow-placed hybrid laminates with large damage indicates a tensile fracture toughness that is higher than that observed for advanced aluminum alloys. Additional recent ATCAS achievements include crown supporting technology, keel quadrant design evaluation, and

  11. Metacatalog of Planetary Surface Features for Multicriteria Evaluation of Surface Evolution: the Integrated Planetary Feature Database

    NASA Astrophysics Data System (ADS)

    Hargitai, Henrik

    2016-10-01

    We have created a metacatalog, or catalog or catalogs, of surface features of Mars that also includes the actual data in the catalogs listed. The goal is to make mesoscale surface feature databases available in one place, in a GIS-ready format. The databases can be directly imported to ArcGIS or other GIS platforms, like Google Mars. Some of the catalogs in our database are also ingested into the JMARS platform.All catalogs have been previously published in a peer-reviewed journal, but they may contain updates of the published catalogs. Many of the catalogs are "integrated", i.e. they merge databases or information from various papers on the same topic, including references to each individual features listed.Where available, we have included shapefiles with polygon or linear features, however, most of the catalogs only contain point data of their center points and morphological data.One of the unexpected results of the planetary feature metacatalog is that some features have been described by several papers, using different, i.e., conflicting designations. This shows the need for the development of an identification system suitable for mesoscale (100s m to km sized) features that tracks papers and thus prevents multiple naming of the same feature.The feature database can be used for multicriteria analysis of a terrain, thus enables easy distribution pattern analysis and the correlation of the distribution of different landforms and features on Mars. Such catalog makes a scientific evaluation of potential landing sites easier and more effective during the selection process and also supports automated landing site selections.The catalog is accessible at https://planetarydatabase.wordpress.com/.

  12. Cognitive Impairment and Dementia in Parkinson’s Disease: Clinical Features, Diagnosis, and Management

    PubMed Central

    Meireles, Joana; Massano, João

    2012-01-01

    Parkinson’s disease (PD) is a common, disabling, neurodegenerative disorder. In addition to classical motor symptoms, non-motor features are now widely accepted as part of the clinical picture, and cognitive decline is a very important aspect of the disease, as it brings an additional significant burden for the patient and caregivers. The diagnosis of cognitive decline in PD, namely mild cognitive impairment (MCI) and dementia, can be extremely challenging, remaining largely based on clinical and cognitive assessments. Diagnostic criteria and methods for PD dementia and MCI have been recently issued by expert work groups. This manuscript has synthesized relevant data in order to obtain a pragmatic and updated review regarding cognitive decline in PD, from milder stages to dementia. This text will summarize clinical features, diagnostic methodology, and therapeutic issues of clinical decline in PD. Relevant clinical genetic issues, including recent advances, will also be approached. PMID:22654785

  13. Feature Inference Learning and Eyetracking

    ERIC Educational Resources Information Center

    Rehder, Bob; Colner, Robert M.; Hoffman, Aaron B.

    2009-01-01

    Besides traditional supervised classification learning, people can learn categories by inferring the missing features of category members. It has been proposed that feature inference learning promotes learning a category's internal structure (e.g., its typical features and interfeature correlations) whereas classification promotes the learning of…

  14. Foundations of Distinctive Feature Theory.

    ERIC Educational Resources Information Center

    Baltaxe, Christiane A. M.

    This treatise on the theoretical and historical foundations of distinctive feature theory traces the evolution of the distinctive features concept in the context of related notions current in linguistic theory, discusses the evolution of individual distinctive features, and criticizes certain acoustic and perceptual correlates attributed to these…

  15. Advanced Solar Cells for Satellite Power Systems

    NASA Technical Reports Server (NTRS)

    Flood, Dennis J.; Weinberg, Irving

    1994-01-01

    The multiple natures of today's space missions with regard to operational lifetime, orbital environment, cost and size of spacecraft, to name just a few, present such a broad range of performance requirements to be met by the solar array that no single design can suffice to meet them all. The result is a demand for development of specialized solar cell types that help to optimize overall satellite performance within a specified cost range for any given space mission. Historically, space solar array performance has been optimized for a given mission by tailoring the features of silicon solar cells to account for the orbital environment and average operating conditions expected during the mission. It has become necessary to turn to entirely new photovoltaic materials and device designs to meet the requirements of future missions, both in the near and far term. This paper will outline some of the mission drivers and resulting performance requirements that must be met by advanced solar cells, and provide an overview of some of the advanced cell technologies under development to meet them. The discussion will include high efficiency, radiation hard single junction cells; monolithic and mechanically stacked multiple bandgap cells; and thin film cells.

  16. Advanced Technologies for Design Information Verification

    SciTech Connect

    Watkins, Michael L.; Sheen, David M.; Rose, Joseph L.; Cumblidge, Stephen E.

    2009-07-08

    This paper discusses several technologies that have the potential to enhance facilities design verification. These approaches have shown promise in addressing the challenges associated with the verification of sub-component geometry and material composition for structures that are not directly accessible for physical inspection. A simple example is a pipe that extends into or through a wall or foundation. Both advanced electromagnetic and acoustic modalities will be discussed. These include advanced radar imaging, transient thermographic imaging, and guided acoustic wave imaging. Examples of current applications are provided. The basic principles and mechanisms of these inspection techniques are presented along with the salient practical features, advantages, and disadvantages of each technique. Other important considerations, such as component geometries, materials, and degree of access are also treated. The importance of, and strategies for, developing valid inspection models are also discussed. Beyond these basic technology adaptation and evaluation issues, important user interface considerations are outlined, along with approaches to quantify the overall performance reliability of the various inspection methods.

  17. Advances in retinal ganglion cell imaging

    PubMed Central

    Balendra, S I; Normando, E M; Bloom, P A; Cordeiro, M F

    2015-01-01

    Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head. One of its most devastating features is its late diagnosis and the resulting irreversible visual loss that is often predictable. Current diagnostic tools require significant RGC or functional visual field loss before the threshold for detection of glaucoma may be reached. To propel the efficacy of therapeutics in glaucoma, an earlier diagnostic tool is required. Recent advances in retinal imaging, including optical coherence tomography, confocal scanning laser ophthalmoscopy, and adaptive optics, have propelled both glaucoma research and clinical diagnostics and therapeutics. However, an ideal imaging technique to diagnose and monitor glaucoma would image RGCs non-invasively with high specificity and sensitivity in vivo. It may confirm the presence of healthy RGCs, such as in transgenic models or retrograde labelling, or detect subtle changes in the number of unhealthy or apoptotic RGCs, such as detection of apoptosing retinal cells (DARC). Although many of these advances have not yet been introduced to the clinical arena, their successes in animal studies are enthralling. This review will illustrate the challenges of imaging RGCs, the main retinal imaging modalities, the in vivo techniques to augment these as specific RGC-imaging tools and their potential for translation to the glaucoma clinic. PMID:26293138

  18. Advanced laser systems for photoacoustic imaging

    NASA Astrophysics Data System (ADS)

    Klosner, Marc; Sampathkumar, Ashwin; Chan, Gary; Wu, Chunbai; Gross, Daniel; Heller, Donald F.

    2015-03-01

    We describe the ongoing development of laser systems for advanced photoacoustic imaging (PAI). We discuss the characteristics of these laser systems and their particular benefits for soft tissue imaging and next-generation breast cancer diagnostics. We provide an overview of laser performance and compare this with other laser systems that have been used for early-stage development of PAI. These advanced systems feature higher pulse energy output at clinically relevant repetition rates, as well as a novel wavelength-cycling output pulse format. Wavelength cycling provides pulse sequences for which the output repeatedly alternates between two wavelengths that provide differential imaging. This capability improves co-registration of captured differential images. We present imaging results of phantoms obtained with a commercial ultrasound detector system and a wavelength-cycling laser source providing ~500 mJ/pulse at 755 and 797 nm, operating at 25 Hz. The results include photoacoustic images and corresponding pulse-echo data from a tissue mimicking phantom containing inclusions, simulating tumors in the breast. We discuss the application of these systems to the contrast-enhanced detection of various tissue types and tumors.

  19. Asymmetric features in the protoplanetary disk MWC 758

    NASA Astrophysics Data System (ADS)

    Benisty, M.; Juhasz, A.; Boccaletti, A.; Avenhaus, H.; Milli, J.; Thalmann, C.; Dominik, C.; Pinilla, P.; Buenzli, E.; Pohl, A.; Beuzit, J.-L.; Birnstiel, T.; de Boer, J.; Bonnefoy, M.; Chauvin, G.; Christiaens, V.; Garufi, A.; Grady, C.; Henning, T.; Huelamo, N.; Isella, A.; Langlois, M.; Ménard, F.; Mouillet, D.; Olofsson, J.; Pantin, E.; Pinte, C.; Pueyo, L.

    2015-06-01

    Context. The study of dynamical processes in protoplanetary disks is essential to understand planet formation. In this context, transition disks are prime targets because they are at an advanced stage of disk clearing and may harbor direct signatures of disk evolution. Aims: We aim to derive new constraints on the structure of the transition disk MWC 758, to detect non-axisymmetric features and understand their origin. Methods: We obtained infrared polarized intensity observations of the protoplanetary disk MWC 758 with VLT/SPHERE at 1.04 μm to resolve scattered light at a smaller inner working angle (0.093'') and a higher angular resolution (0.027'') than previously achieved. Results: We observe polarized scattered light within 0.53'' (148 au) down to the inner working angle (26 au) and detect distinct non-axisymmetric features but no fully depleted cavity. The two small-scale spiral features that were previously detected with HiCIAO are resolved more clearly, and new features are identified, including two that are located at previously inaccessible radii close to the star. We present a model based on the spiral density wave theory with two planetary companions in circular orbits. The best model requires a high disk aspect ratio (H/r ~ 0.20 at the planet locations) to account for the large pitch angles which implies a very warm disk. Conclusions: Our observations reveal the complex morphology of the disk MWC 758. To understand the origin of the detected features, the combination of high-resolution observations in the submillimeter with ALMA and detailed modeling is needed. Based on observations performed with VLT/SPHERE under program ID 60-9389(A).Appendices are available in electronic form at http://www.aanda.orgESO data is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/578/L6

  20. Confocal and Two-Photon Microscopy: Foundations, Applications and Advances

    NASA Astrophysics Data System (ADS)

    Diaspro, Alberto

    2001-11-01

    Confocal and Two-Photon Microscopy Foundations, Applications, and Advances Edited by Alberto Diaspro Confocal and two-photon fluorescence microscopy has provided researchers with unique possibilities of three-dimensional imaging of biological cells and tissues and of other structures such as semiconductor integrated circuits. Confocal and Two-Photon Microscopy: Foundations, Applications, and Advances provides clear, comprehensive coverage of basic foundations, modern applications, and groundbreaking new research developments made in this important area of microscopy. Opening with a foreword by G. J. Brakenhoff, this reference gathers the work of an international group of renowned experts in chapters that are logically divided into balanced sections covering theory, techniques, applications, and advances, featuring: In-depth discussion of applications for biology, medicine, physics, engineering, and chemistry, including industrial applications Guidance on new and emerging imaging technology, developmental trends, and fluorescent molecules Uniform organization and review-style presentation of chapters, with an introduction, historical overview, methodology, practical tips, applications, future directions, chapter summary, and bibliographical references Companion FTP site with full-color photographs The significant experience of pioneers, leaders, and emerging scientists in the field of confocal and two-photon excitation microscopy Confocal and Two-Photon Microscopy: Foundations, Applications, and Advances is invaluable to researchers in the biological sciences, tissue and cellular engineering, biophysics, bioengineering, physics of matter, and medicine, who use these techniques or are involved in developing new commercial instruments.

  1. Terminal area considerations for an advanced CTOL transport aircraft

    NASA Technical Reports Server (NTRS)

    Sussman, M. B.

    1975-01-01

    Projected future conditions at large urban airports were used to identify design objectives for a long-haul, advanced transport airplane introduced for operation in the mid-1980s. Operating constraints associated with airport congestion and aircraft noise and emissions were of central interest. In addition, some of the interaction of these constraints with aircraft fuel usage were identified. The study allowed for advanced aircraft design features consistent with the future operating period. A baseline 200 passenger airplane design was modified to comply with design requirements imposed by terminal area constraints. Specific design changes included: (1) modification of engine arrangement; wing planform; (2) drag and spoiler surfaces; (3) secondary power systems; (4) brake and landing gear characteristics; and (5) the aircraft avionics. These changes, based on exploratory design estimates and allowing for technology advance, were judged to enable the airplane to: reduce wake turbulence; handle steeper descent paths with fewer limitation due to engine characteristics; reduce runway occupancy times; improve community noise contours; and reduce the total engine emittants deposited in the terminal area. The penalties to airplane performance and operating cost associated with improving the terminal area characteristics of the airplane were assessed. Finally, key research problems requiring solution in order to validate the assumed advanced airplane technology were identified.

  2. ADVANCED HYBRID PARTICULATE COLLECTOR

    SciTech Connect

    Ye Zhuang; Stanley J. Miller; Michelle R. Olderbak; Rich Gebert

    2001-12-01

    A new concept in particulate control, called an advanced hybrid particulate collector (AHPC), is being developed under funding from the U.S. Department of Energy. The AHPC combines the best features of electrostatic precipitators (ESPs) and baghouses in an entirely novel manner. The AHPC concept combines fabric filtration and electrostatic precipitation in the same housing, providing major synergism between the two methods, both in the particulate collection step and in transfer of dust to the hopper. The AHPC provides ultrahigh collection efficiency, overcoming the problem of excessive fine-particle emissions with conventional ESPs, and solves the problem of reentrainment and re-collection of dust in conventional baghouses. Phase I of the development effort consisted of design, construction, and testing of a 5.7-m{sup 3}/min (200-acfm) working AHPC model. Results from both 8-hr parametric tests and 100-hr proof-of-concept tests with two different coals demonstrated excellent operability and greater than 99.99% fine-particle collection efficiency. Since all of the developmental goals of Phase I were met, the approach was scaled up in Phase II to a size of 255 m{sup 3}/min (9000 acfm) (equivalent in size to 2.5 MW) and was installed on a slipstream at the Big Stone Power Plant. For Phase II, the AHPC at Big Stone Power Plant was operated continuously from late July 1999 until mid-December 1999. The Phase II results were highly successful in that ultrahigh particle collection efficiency was achieved, pressure drop was well controlled, and system operability was excellent. For Phase III, the AHPC was modified into a more compact configuration, and components were installed that were closer to what would be used in a full-scale commercial design. The modified AHPC was operated from April to July 2000. While operational results were acceptable during this time, inspection of bags in the summer of 2000 revealed some membrane damage to the fabric that appeared to be

  3. Advanced Materials in Support of EERE Needs to Advance Clean Energy Technologies Program Implementation

    SciTech Connect

    Liby, Alan L; Rogers, Hiram

    2013-10-01

    The goal of this activity was to carry out program implementation and technical projects in support of the ARRA-funded Advanced Materials in Support of EERE Needs to Advance Clean Energy Technologies Program of the DOE Advanced Manufacturing Office (AMO) (formerly the Industrial Technologies Program (ITP)). The work was organized into eight projects in four materials areas: strategic materials, structural materials, energy storage and production materials, and advanced/field/transient processing. Strategic materials included work on titanium, magnesium and carbon fiber. Structural materials included work on alumina forming austentic (AFA) and CF8C-Plus steels. The advanced batteries and production materials projects included work on advanced batteries and photovoltaic devices. Advanced/field/transient processing included work on magnetic field processing. Details of the work in the eight projects are available in the project final reports which have been previously submitted.

  4. SCIENCE BRIEF: ADVANCED CONCEPTS

    EPA Science Inventory

    Research on advanced concepts will evaluate and demonstrate the application of innovative infrastructure designs, management procedures and operational approaches. Advanced concepts go beyond simple asset management. The infusion of these advanced concepts into established wastew...

  5. Aging and Developmental Disabilities. Feature Issue.

    ERIC Educational Resources Information Center

    Anderson, Deborah, Ed.; And Others

    1993-01-01

    This feature issue of a bulletin on community integration points out the challenge of making service systems more familiar with and responsive to the needs of older adults with developmental disabilities and their families. It includes articles with the following titles and authors: "Living on the Edge" (Arthur Campbell, Jr.); "Aging and…

  6. Hypermedia: Functional Features and Research Issues.

    ERIC Educational Resources Information Center

    Park, Ok-choon

    1991-01-01

    Examines desirable functional features of hypermedia; describes its instructional uses and limitations; and discusses research issues, including learner control principles, the selection of information representation forms, the use of hypermedia as a knowledge base for computer-based instruction (CBI), and the development of intelligent…

  7. Advanced Technology Vehicle Testing

    SciTech Connect

    James Francfort

    2003-11-01

    The light-duty vehicle transportation sector in the United States depends heavily on imported petroleum as a transportation fuel. The Department of Energy’s Advanced Vehicle Testing Activity (AVTA) is testing advanced technology vehicles to help reduce this dependency, which would contribute to the economic stability and homeland security of the United States. These advanced technology test vehicles include internal combustion engine vehicles operating on 100% hydrogen (H2) and H2CNG (compressed natural gas) blended fuels, hybrid electric vehicles, neighborhood electric vehicles, urban electric vehicles, and electric ground support vehicles. The AVTA tests and evaluates these vehicles with closed track and dynamometer testing methods (baseline performance testing) and accelerated reliability testing methods (accumulating lifecycle vehicle miles and operational knowledge within 1 to 1.5 years), and in normal fleet environments. The Arizona Public Service Alternative Fuel Pilot Plant and H2-fueled vehicles are demonstrating the feasibility of using H2 as a transportation fuel. Hybrid, neighborhood, and urban electric test vehicles are demonstrating successful applications of electric drive vehicles in various fleet missions. The AVTA is also developing electric ground support equipment (GSE) test procedures, and GSE testing will start during the fall of 2003. All of these activities are intended to support U.S. energy independence. The Idaho National Engineering and Environmental Laboratory manages these activities for the AVTA.

  8. Feature Assignment in Perception of Auditory Figure

    PubMed Central

    Gregg, Melissa K.; Samuel, Arthur G.

    2012-01-01

    Because the environment often includes multiple sounds that overlap in time, listeners must segregate a sound of interest (the auditory figure) from other co-occurring sounds (the unattended auditory ground). We conducted a series of experiments to clarify the principles governing the extraction of auditory figures. We distinguish between auditory “objects” (relatively punctate events, such as a dog's bark) and auditory “streams” (sounds involving a pattern over time, such as a galloping rhythm). In Experiments 1 and 2, on each trial two sounds -- an object (a vowel) and a stream (a series of tones) – were presented with one target feature that could be perceptually grouped with either source. In each block of these experiments, listeners were required to attend to one of the two sounds, and report its perceived category. Across several experimental manipulations, listeners were more likely to allocate the feature to an impoverished object if the result of the grouping was a good, identifiable object. Perception of objects was quite sensitive to feature variation (noise masking), whereas perception of streams was more robust to feature variation. In Experiment 3, the number of sound sources competing for the feature was increased to three. This produced a shift toward relying more on spatial cues than on the potential contribution of the feature to an object's perceptual quality. The results support a distinction between auditory objects and streams, and provide new information about the way that the auditory world is parsed. PMID:22288691

  9. AVNG authentication features

    SciTech Connect

    Thron, Jonathan Louis; Mac Arthur, Duncan W; White, Greg; Razinkov, Sergey; Livke, Alexander

    2010-01-01

    Any verification measurement performed on potentially classified nuclear material must satisfy two seemingly contradictory constraints. First and foremost, no classified information can be released. At the same time, the monitoring party must have confidence in the veracity of the measurement (called authentication). An information barrier (IB) is included in the measurement system to protect the potentially classified information. To achieve both goals, the IB allows only very limited, previously agreed-on information to be displayed to the monitoring party. In addition to this limited information from the potentially classified measurement, other measurements are performed and procedures are put in place for the monitoring party to gain confidence that the material being measured is consistent with the host's declarations concerning that material. In this presentation, we will discuss the techniques used in the AVNG attribute measuring system to facilitate authentication of the verification measurements by the monitors. These techniques include measuring unclassified items while allowing more information to be displayed; having the monitor understand the system function, design, and implementation; and randomly selecting the order of measurements.

  10. Advanced Optical Network

    NASA Astrophysics Data System (ADS)

    Braun, Steve; Michael, Xuejun

    The following article describes an advanced dense wavelength division multiplexing (DWDM) Optical Network developed by L-3 Photonics. The network, configured as an amplified optical bus, carries traffic simultaneously in both directions, using multiple wavelengths. As a result, data distribution is of the form peer-to-multi-peer, it is protocol independent, and it is scalable. The network leverages the rapid growth in commercial optical technologies, including wavelength division multiplexing (WDM), and when applied to military and commercial platforms such as aircraft, ships, unmanned and other vehicles, provides a cost-effective, low-weight, high-speed, and high noise-immune data distribution system.

  11. Horizontal Advanced Tensiometer

    SciTech Connect

    Hubbell, Joel M.; Sisson, James B.

    2004-06-22

    An horizontal advanced tensiometer is described that allows the monitoring of the water pressure of soil positions, particularly beneath objects or materials that inhibit the use of previous monitoring wells. The tensiometer includes a porous cup, a pressure transducer (with an attached gasket device), an adaptive chamber, at least one outer guide tube which allows access to the desired horizontal position, a transducer wire, a data logger and preferably an inner guide tube and a specialized joint which provides pressure on the inner guide tube to maintain the seal between the gasket of the transducer and the adaptive chamber.

  12. Space Shuttle Main Engine: Advanced Health Monitoring System

    NASA Technical Reports Server (NTRS)

    Singer, Chirs

    1999-01-01

    The main gola of the Space Shuttle Main Engine (SSME) Advanced Health Management system is to improve flight safety. To this end the new SSME has robust new components to improve the operating margen and operability. The features of the current SSME health monitoring system, include automated checkouts, closed loop redundant control system, catastropic failure mitigation, fail operational/ fail-safe algorithms, and post flight data and inspection trend analysis. The features of the advanced health monitoring system include: a real time vibration monitor system, a linear engine model, and an optical plume anomaly detection system. Since vibration is a fundamental measure of SSME turbopump health, it stands to reason that monitoring the vibration, will give some idea of the health of the turbopumps. However, how is it possible to avoid shutdown, when it is not necessary. A sensor algorithm has been developed which has been exposed to over 400 test cases in order to evaluate the logic. The optical plume anomaly detection (OPAD) has been developed to be a sensitive monitor of engine wear, erosion, and breakage.

  13. Environmental Sustainability - Including Land and Water Use

    EPA Science Inventory

    Assessments of environmental sustainability can be conducted in many ways with one of the most quantitative methods including Life Cycle Impact Assessment (LCIA). While historically LCIA has included a comprehensive list of impact categories including: ozone depletion, global c...

  14. New Features in ADS Labs

    NASA Astrophysics Data System (ADS)

    Accomazzi, Alberto; Kurtz, M. J.; Henneken, E. A.; Grant, C. S.; Thompson, D.; Di Milia, G.; Luker, J.; Murray, S. S.

    2013-01-01

    The NASA Astrophysics Data System (ADS) has been working hard on updating its services and interfaces to better support our community's research needs. ADS Labs is a new interface built on the old tried-and-true ADS Abstract Databases, so all of ADS's content is available through it. In this presentation we highlight the new features that have been developed in ADS Labs over the last year: new recommendations, metrics, a citation tool and enhanced fulltext search. ADS Labs has long been providing article-level recommendations based on keyword similarity, co-readership and co-citation analysis of its corpus. We have now introduced personal recommendations, which provide a list of articles to be considered based on a individual user's readership history. A new metrics interface provides a summary of the basic impact indicators for a list of records. These include the total and normalized number of papers, citations, reads, and downloads. Also included are some of the popular indices such as the h, g and i10 index. The citation helper tool allows one to submit a set of records and obtain a list of top 10 papers which cite and/or are cited by papers in the original list (but which are not in it). The process closely resembles the network approach of establishing "friends of friends" via an analysis of the citation network. The full-text search service now covers more than 2.5 million documents, including all the major astronomy journals, as well as physics journals published by Springer, Elsevier, the American Physical Society, the American Geophysical Union, and all of the arXiv eprints. The full-text search interface interface allows users and librarians to dig deep and find words or phrases in the body of the indexed articles. ADS Labs is available at http://adslabs.org

  15. Advanced diesel engine component development program, tasks 4-14

    NASA Astrophysics Data System (ADS)

    Kaushal, Tony S.; Weber, Karen E.

    1994-11-01

    This report summarizes the Advanced Diesel Engine Component Development (ADECD) Program to develop and demonstrate critical technology needed to advance the heavy-duty low heat rejection engine concept. Major development activities reported are the design, analysis, and fabrication of monolithic ceramic components; vapor phase and solid film lubrication; electrohydraulic valve actuation; and high pressure common rail injection. An advanced single cylinder test bed was fabricated as a laboratory tool in studying these advanced technologies. This test bed simulates the reciprocator for a system having no cooling system, turbo compounding, Rankine bottoming cycle, common rail injection, and variable valve actuation to achieve fuel consumption of 160 g/kW-hr (.26 lb/hp-hr). The advanced concepts were successfully integrated into the test engine. All ceramic components met their functional and reliability requirements. The firedeck, cast-in-place ports, valves, valve guides, piston cap, and piston ring were made from silicon nitride. Breakthroughs required to implement a 'ceramic' engine included the fabrication of air-gap cylinder heads, elimination of compression gaskets, machining of ceramic valve seats within the ceramic firedeck, fabrication of cast-in-place ceramic port liners, implementation of vapor phase lubrication, and elimination of the engine coolant system. Silicon nitride valves were successfully developed to meet several production abuse test requirements and incorporated into the test bed with a ceramic valve guide and solid film lubrication. The ADECD cylinder head features ceramic port shields to increase insulation and exhaust energy recovery. The combustion chamber includes a ceramic firedeck and piston cap. The tribological challenge posed by top ring reversal temperatures of 550 C was met through the development of vapor phase lubrication using tricresyl phosphate at the ring-liner interface. A solenoid-controlled, variable valve actuation system

  16. Advanced diesel engine component development program, tasks 4-14

    NASA Technical Reports Server (NTRS)

    Kaushal, Tony S.; Weber, Karen E.

    1994-01-01

    This report summarizes the Advanced Diesel Engine Component Development (ADECD) Program to develop and demonstrate critical technology needed to advance the heavy-duty low heat rejection engine concept. Major development activities reported are the design, analysis, and fabrication of monolithic ceramic components; vapor phase and solid film lubrication; electrohydraulic valve actuation; and high pressure common rail injection. An advanced single cylinder test bed was fabricated as a laboratory tool in studying these advanced technologies. This test bed simulates the reciprocator for a system having no cooling system, turbo compounding, Rankine bottoming cycle, common rail injection, and variable valve actuation to achieve fuel consumption of 160 g/kW-hr (.26 lb/hp-hr). The advanced concepts were successfully integrated into the test engine. All ceramic components met their functional and reliability requirements. The firedeck, cast-in-place ports, valves, valve guides, piston cap, and piston ring were made from silicon nitride. Breakthroughs required to implement a 'ceramic' engine included the fabrication of air-gap cylinder heads, elimination of compression gaskets, machining of ceramic valve seats within the ceramic firedeck, fabrication of cast-in-place ceramic port liners, implementation of vapor phase lubrication, and elimination of the engine coolant system. Silicon nitride valves were successfully developed to meet several production abuse test requirements and incorporated into the test bed with a ceramic valve guide and solid film lubrication. The ADECD cylinder head features ceramic port shields to increase insulation and exhaust energy recovery. The combustion chamber includes a ceramic firedeck and piston cap. The tribological challenge posed by top ring reversal temperatures of 550 C was met through the development of vapor phase lubrication using tricresyl phosphate at the ring-liner interface. A solenoid-controlled, variable valve actuation system

  17. Advanced Vehicle Testing and Evaluation

    SciTech Connect

    Garetson, Thomas

    2013-03-31

    The objective of the United States (U.S.) Department of Energy's (DOEs) Advanced Vehicle Testing and Evaluation (AVTE) project was to provide test and evaluation services for advanced technology vehicles, to establish a performance baseline, to determine vehicle reliability, and to evaluate vehicle operating costs in fleet operations.Vehicles tested include light and medium-duty vehicles in conventional, hybrid, and all-electric configurations using conventional and alternative fuels, including hydrogen in internal combustion engines. Vehicles were tested on closed tracks and chassis dynamometers, as well as operated on public roads, in fleet operations, and over prescribed routes. All testing was controlled by procedures developed specifically to support such testing.

  18. Management of advanced corneal ectasias.

    PubMed

    Maharana, Prafulla K; Dubey, Aditi; Jhanji, Vishal; Sharma, Namrata; Das, Sujata; Vajpayee, Rasik B

    2016-01-01

    Corneal ectasias include a group of disorders characterised by progressive thinning, bulging and distortion of the cornea. Keratoconus is the most common disease in this group. Other manifestations include pellucid marginal degeneration, Terrien's marginal degeneration, keratoglobus and ectasias following surgery. Advanced ectasias usually present with loss of vision due to high irregular astigmatism. Management of these disorders is difficult due to the peripheral location of ectasia and associated severe corneal thinning. Newer contact lenses such as scleral lenses are helpful in a selected group of patients. A majority of these cases requires surgical intervention. This review provides an update on the current treatment modalities available for management of advanced corneal ectasias. PMID:26294106

  19. Advanced Nuclear Fuel Cycle Options

    SciTech Connect

    Roald Wigeland; Temitope Taiwo; Michael Todosow; William Halsey; Jess Gehin

    2010-06-01

    A systematic evaluation has been conducted of the potential for advanced nuclear fuel cycle strategies and options to address the issues ascribed to the use of nuclear power. Issues included nuclear waste management, proliferation risk, safety, security, economics and affordability, and sustainability. The two basic strategies, once-through and recycle, and the range of possibilities within each strategy, are considered for all aspects of the fuel cycle including options for nuclear material irradiation, separations if needed, and disposal. Options range from incremental changes to today’s implementation to revolutionary concepts that would require the development of advanced nuclear technologies.

  20. Therapy of metastatic pancreatic neuroendocrine tumors (pNETs): recent insights and advances

    PubMed Central

    Ito, Tetsuhide; Igarashi, Hisato

    2013-01-01

    Neuroendocrine tumors (NETs) [carcinoids, pancreatic neuroendocrine tumors (pNETs)] are becoming an increasing clinical problem because not only are they increasing in frequency, but they can frequently present with advanced disease that requires diagnostic and treatment approaches different from those used in the neoplasms that most physicians are used to seeing and treating. In the past few years there have been numerous advances in all aspects of NETs including: an understanding of their unique pathogenesis; specific classification systems developed which have prognostic value; novel methods of tumor localization developed; and novel treatment approaches described. In patients with advanced metastatic disease these include the use of newer chemotherapeutic approaches, an increased understanding of the role of surgery and cytoreductive methods, the development of methods for targeted delivery of cytotoxic agents, and the development of targeted medical therapies (everolimus, sunitinib) based on an increased understanding of the disease biology. Although pNETs and gastrointestinal NETs share many features, recent studies show they differ in pathogenesis and in many aspects of diagnosis and treatment, including their responsiveness to different therapies. Because of limited space, this review will be limited to the advances made in the management and treatment of patients with advanced metastatic pNETs over the past 5 years. PMID:22886480

  1. Evolution paths for advanced automation

    NASA Technical Reports Server (NTRS)

    Healey, Kathleen J.

    1990-01-01

    As Space Station Freedom (SSF) evolves, increased automation and autonomy will be required to meet Space Station Freedom Program (SSFP) objectives. As a precursor to the use of advanced automation within the SSFP, especially if it is to be used on SSF (e.g., to automate the operation of the flight systems), the underlying technologies will need to be elevated to a high level of readiness to ensure safe and effective operations. Ground facilities supporting the development of these flight systems -- from research and development laboratories through formal hardware and software development environments -- will be responsible for achieving these levels of technology readiness. These facilities will need to evolve support the general evolution of the SSFP. This evolution will include support for increasing the use of advanced automation. The SSF Advanced Development Program has funded a study to define evolution paths for advanced automaton within the SSFP's ground-based facilities which will enable, promote, and accelerate the appropriate use of advanced automation on-board SSF. The current capability of the test beds and facilities, such as the Software Support Environment, with regard to advanced automation, has been assessed and their desired evolutionary capabilities have been defined. Plans and guidelines for achieving this necessary capability have been constructed. The approach taken has combined indepth interviews of test beds personnel at all SSF Work Package centers with awareness of relevant state-of-the-art technology and technology insertion methodologies. Key recommendations from the study include advocating a NASA-wide task force for advanced automation, and the creation of software prototype transition environments to facilitate the incorporation of advanced automation in the SSFP.

  2. Maximum likelihood clustering with dependent feature trees

    NASA Technical Reports Server (NTRS)

    Chittineni, C. B. (Principal Investigator)

    1981-01-01

    The decomposition of mixture density of the data into its normal component densities is considered. The densities are approximated with first order dependent feature trees using criteria of mutual information and distance measures. Expressions are presented for the criteria when the densities are Gaussian. By defining different typs of nodes in a general dependent feature tree, maximum likelihood equations are developed for the estimation of parameters using fixed point iterations. The field structure of the data is also taken into account in developing maximum likelihood equations. Experimental results from the processing of remotely sensed multispectral scanner imagery data are included.

  3. Webcam classification using simple features

    NASA Astrophysics Data System (ADS)

    Pramoun, Thitiporn; Choe, Jeehyun; Li, He; Chen, Qingshuang; Amornraksa, Thumrongrat; Lu, Yung-Hsiang; Delp, Edward J.

    2015-03-01

    Thousands of sensors are connected to the Internet and many of these sensors are cameras. The "Internet of Things" will contain many "things" that are image sensors. This vast network of distributed cameras (i.e. web cams) will continue to exponentially grow. In this paper we examine simple methods to classify an image from a web cam as "indoor/outdoor" and having "people/no people" based on simple features. We use four types of image features to classify an image as indoor/outdoor: color, edge, line, and text. To classify an image as having people/no people we use HOG and texture features. The features are weighted based on their significance and combined. A support vector machine is used for classification. Our system with feature weighting and feature combination yields 95.5% accuracy.

  4. Boosting Shift-Invariant Features

    NASA Astrophysics Data System (ADS)

    Hörnlein, Thomas; Jähne, Bernd

    This work presents a novel method for training shift-invariant features using a Boosting framework. Features performing local convolutions followed by subsampling are used to achieve shift-invariance. Other systems using this type of features, e.g. Convolutional Neural Networks, use complex feed-forward networks with multiple layers. In contrast, the proposed system adds features one at a time using smoothing spline base classifiers. Feature training optimizes base classifier costs. Boosting sample-reweighting ensures features to be both descriptive and independent. Our system has a lower number of design parameters as comparable systems, so adapting the system to new problems is simple. Also, the stage-wise training makes it very scalable. Experimental results show the competitiveness of our approach.

  5. Multi-tube fuel nozzle with mixing features

    SciTech Connect

    Hughes, Michael John

    2014-04-22

    A system includes a multi-tube fuel nozzle having an inlet plate and a plurality of tubes adjacent the inlet plate. The inlet plate includes a plurality of apertures, and each aperture includes an inlet feature. Each tube of the plurality of tubes is coupled to an aperture of the plurality of apertures. The multi-tube fuel nozzle includes a differential configuration of inlet features among the plurality of tubes.

  6. [Dengue fever: clinical features].

    PubMed

    Dellamonica, P

    2009-10-01

    The vector for dengue fever and chikungunya, Aedes albopictus, was recently identified in Southeastern France, although the usual vector for dengue fever is Aedes aegypti, raising the possibility of cases occurring among the local population via viraemic individuals returning from endemic areas. Dengue fever is usually transmitted by Aedes aegypti. It is due to an arbovirus-flavivirus of which four different serotypes are known: Den 1 to 4. Each serotype is responsible for specific prolonged immunity but no cross-reactivity exists between serotypes. Clinically, the onset is abrupt with frontal headache, retro-orbital pain, myalgia, joint pain, prostration and, in many cases, a macular rash usually sparing the face and extremities. Haemorrhagic signs may occur, such as petechiae, purpura, epistaxis or bleeding gingivae. Two severe forms of dengue fever, particularly among children below 3 years of age, include dengue haemorrhagic fever (DHF) and DHF with shock (dengue shock syndrome). If a case is suspected in metropolitan France, the diagnosis should be systematically confirmed by positive specific IgM, RT-PCR or viral isolation. Treatment of dengue fever, whether in its uncomplicated form or with hemorrhagic manifestations or shock, remains symptomatic. There is no specific anti-viral treatment. A case should be notified to allow French health authorities to take the appropriate measures for vector control.

  7. Advances in the theory and application of BSF cells. [including electrical resistivity and photovoltaic cells

    NASA Technical Reports Server (NTRS)

    Mandelkorn, J.; Lamneck, J. H.

    1975-01-01

    The characteristics and behavior of p(+), p solar cells were investigated. The p(+), p cells were made by the removal of the n(+) surface layers from n(+), p p(+), BSF cells followed by application of a suitable contact to the resultant p(+), p structures. The open circuit voltage of p(+), p cells was found to increase with increasing 'p' bulk resistivity. The measured open circuit velocity-temperature coefficients were positive and increased with increasing resistivity. An outline of prior limitations in solar cell design is presented, and the removal of these limitations through use of BSF effects is pointed out. The study of BSF effects made feasible production of very thin high efficiency silicon cells as well as high resistivity-high efficiency cells, two desirable types of silicon cells which were previously impossible to make.

  8. [Advancement of maggot including living body to treat chronic infected wounds].

    PubMed

    Zhang, Zhen; Wang, Shouyu; Diao, Yunpeng; Zhang, Houli; Huang, Shanshan; Lv, Decheng

    2009-12-01

    Human has used maggot to treat diseases for thousands of years. In recent years, with abuse of antibiotic and the rising incidence of antibiotic resistance, maggot therapy, as a surgical alternative, is mainly applied to treat chronic infected wounds on account of its low cost, efficacy and safety. Its mechanisms are disinfection, bio-debridement and enhancement of tissue regeneration. Maggot therapy which serves as a kind of biological therapy is promising. However, living maggot therapy could result in inevitable complications, so that we should apply traditional Chinese medicine theory to investigate and develop new delivery method of maggot. The review summarizes the past and present of maggot therapy.

  9. Advanced energy storage for space applications: A follow-up

    NASA Technical Reports Server (NTRS)

    Halpert, Gerald; Surampudi, Subbarao

    1994-01-01

    Viewgraphs on advanced energy storage for space applications are presented. Topics covered include: categories of space missions using batteries; battery challenges; properties of SOA and advanced primary batteries; lithium primary cell applications; advanced rechargeable battery applications; present limitations of advanced battery technologies; and status of Li-TiS2, Ni-MH, and Na-NiCl2 cell technologies.

  10. Using Advanced Scientific Diving Technologies to Assess the Underwater Environment

    SciTech Connect

    Southard, John A.; Williams, Greg D.; Sargeant, Susan L.; Diefenderfer, Heida L.; Blanton, Michael L.

    2003-03-31

    Scientific diving can provide unique information for addressing complex environmental issues in the marine environment and is applied to a variety of increasingly important issues throughout Puget Sound, including habitat degradation, endangered species, biological availability of contaminants, and the effects of overwater structures and shoreline protection features. The Pacific Northwest National Laboratory, Battelle Marine Sciences Laboratory uses trained scientific divers in conjunction with advanced technologies to collect in-situ information best obtained through direct observation and requiring minimal environmental disturbance. For example, advances in underwater communications allow divers to discuss observations and data collection techniques in real time, both with each other and with personnel on the surface. Other examples include the use of Dual frequency IDentification SONar (DIDSON), an underwater camera used to capture digital images of benthic structures, fish, and organisms during low light and high turbidity levels; the use of voice-narrated underwater video; and the development of sediment collection methods yielding one-meter cores. The combination of using trained scientific SCUBA divers and advanced underwater technologies is a key element in addressing multifaceted environmental problems, resulting in a more comprehensive understanding of the underwater environment and more reliable data with which to make resource management decisions.

  11. Design of the advanced regional aircraft, the DART-75

    NASA Technical Reports Server (NTRS)

    Elliot, Steve; Gislason, Jason; Huffstetler, Mark; Mann, Jon; Withers, Ashley; Zimmerman, Mark

    1992-01-01

    The need for regional aircraft stems from the problem of hub airport congestion. Regional travel will allow a passenger to commute from one spoke city to another spoke city without entering the congested hub airport. In addition, those people traveling longer routes may begin the flight at home instead of traveling to the hub airport. At this time, there is no American aerospace company that produces a regional transport for under 100 passengers. The intention of the Developmental Advanced Regional Transport (DART-75) is to fill this void with a modern, efficient regional aircraft. This design achieves the efficiency through a number of advanced features including three lifting surfaces, partial composite construction, and an advanced engine design. Efficiency is not the only consideration. Structural integrity, fatigue life, ease of maintenance, passenger comfort and convenience, and environmental aspects must all be considered. These factors force the design team to face many tradeoffs that are studied to find the best solution. The final consideration that cannot be overlooked is that of cost. The DART-75 is a 75-passenger medium-range regional transport intended for spoke-to-spoke, spoke-to-hub, and some hub-to-hub operations. Included are the general descriptions of the structures, weight and balance, stability and control, performance, and engine design.

  12. FEATURE 3, LARGE GUN POSITION, ARMCO HUT (FEATURE 4) IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FEATURE 3, LARGE GUN POSITION, ARMCO HUT (FEATURE 4) IN BACKGROUND, VIEW FACING NORTH. - Naval Air Station Barbers Point, Anti-Aircraft Battery Complex-Large Gun Position, East of Coral Sea Road, northwest of Hamilton Road, Ewa, Honolulu County, HI

  13. New PAMTRAK features

    SciTech Connect

    Dahly, B.; Anspach, J.

    1995-07-01

    Sandia is developing a Personnel and Material Tracking System (PAMTRAK) which uses a variety of techniques to monitor material inside a vault in real-time. It can detect material movement using video cameras inside the vault or motion sensors attached to the material. It also contains two prototype attribute monitoring systems that continuously measure material weight, temperature or movement. A site can use any of these alone or together to extend physical inventory intervals. PAMTRAK can reduce the cost of storing material by reducing inventory frequency and radiation exposure to workers. Analysis at Savannah River in 1992 estimated that installing PAMTRAK in the 7 active and future vaults at that site would save $1,073,000 per year by reducing inventory frequency from monthly to yearly. Performing similar calculations now, assuming lower radiation exposure limits of 700m Rem per year, new inventory reduction guidelines allowing a baseline interval of 6 months, and an achieved inventory interval of 3 years, results in an estimated average savings of $400,000 per year. PAMTRAK, since it is real-time, can detect theft or diversion soon enough to give the guard force a chance of recovering the material and apprehending the perpetrator. In performing an inventory a site typically checks only a fraction of the material using random, statistical sampling, while PAMTRAK monitors all material in the vault. In addition to static environments such as vaults, PAMTRAK can be used to protect material in active work areas. Several of the sensor types can ignore activity around material but still report alarms if the material is moved or handled. PAMTRAK includes a personnel tracking capability that allows a site to monitor and restrict personnel movements. It can exclude workers from designated areas unless they have explicit permission to be there. It can also enforce the 2-person rule by requiring a worker to be accompanied by at least one other qualified worker.

  14. Synergistic combination of clinical and imaging features predicts abnormal imaging patterns of pulmonary infections

    PubMed Central

    Bagci, Ulas; Jaster-Miller, Kirsten; Olivier, Kenneth N.; Yao, Jianhua; Mollura, Daniel J.

    2013-01-01

    We designed and tested a novel hybrid statistical model that accepts radiologic image features and clinical variables, and integrates this information in order to automatically predict abnormalities in chest computed-tomography (CT) scans and identify potentially important infectious disease biomarkers. In 200 patients, 160 with various pulmonary infections and 40 healthy controls, we extracted 34 clinical variables from laboratory tests and 25 textural features from CT images. From the CT scans, pleural effusion (PE), linear opacity (or thickening) (LT), tree-in-bud (TIB), pulmonary nodules, ground glass opacity (GGO), and consolidation abnormality patterns were analyzed and predicted through clinical, textural (imaging), or combined attributes. The presence and severity of each abnormality pattern was validated by visual analysis of the CT scans. The proposed biomarker identification system included two important steps: (i) a coarse identification of an abnormal imaging pattern by adaptively selected features (AmRMR), and (ii) a fine selection of the most important features from the previous step, and assigning them as biomarkers, depending on the prediction accuracy. Selected biomarkers were used to classify normal and abnormal patterns by using a boosted decision tree (BDT) classifier. For all abnormal imaging patterns, an average prediction accuracy of 76.15% was obtained. Experimental results demonstrated that our proposed biomarker identification approach is promising and may advance the data processing in clinical pulmonary infection research and diagnostic techniques. PMID:23930819

  15. Computational Identification of Genomic Features That Influence 3D Chromatin Domain Formation

    PubMed Central

    Mourad, Raphaël; Cuvier, Olivier

    2016-01-01

    Recent advances in long-range Hi-C contact mapping have revealed the importance of the 3D structure of chromosomes in gene expression. A current challenge is to identify the key molecular drivers of this 3D structure. Several genomic features, such as architectural proteins and functional elements, were shown to be enriched at topological domain borders using classical enrichment tests. Here we propose multiple logistic regression to identify those genomic features that positively or negatively influence domain border establishment or maintenance. The model is flexible, and can account for statistical interactions among multiple genomic features. Using both simulated and real data, we show that our model outperforms enrichment test and non-parametric models, such as random forests, for the identification of genomic features that influence domain borders. Using Drosophila Hi-C data at a very high resolution of 1 kb, our model suggests that, among architectural proteins, BEAF-32 and CP190 are the main positive drivers of 3D domain borders. In humans, our model identifies well-known architectural proteins CTCF and cohesin, as well as ZNF143 and Polycomb group proteins as positive drivers of domain borders. The model also reveals the existence of several negative drivers that counteract the presence of domain borders including P300, RXRA, BCL11A and ELK1. PMID:27203237

  16. Ohio Advanced Energy Manufacturing Center

    SciTech Connect

    Kimberly Gibson; Mark Norfolk

    2012-07-30

    health. To aid the overall advanced energy industry, EWI developed and launched an Ohio chapter of the non-profit Advanced Energy Economy. In this venture, Ohio joins with six other states including Colorado, Connecticut, Illinois, Maine, Massachusetts, New Hampshire, Rhode Island and Vermont to help promote technologies that deliver energy that is affordable, abundant and secure. In a more specific arena, EWI's advanced energy group collaborated with the EWI-run Nuclear Fabrication Consortium to promote the nuclear supply chain. Through this project EWI has helped bring the supply chain up to date for the upcoming period of construction, and assisted them in understanding the demands for the next generation of facilities now being designed. In a more targeted manner, EWI worked with 115 individual advanced energy companies that are attempting to bring new technology to market. First, these interactions helped EWI develop an awareness of issues common to companies in different advanced energy sectors. By identifying and addressing common issues, EWI helps companies bring technology to market sooner and at a lower cost. These visits also helped EWI develop a picture of industry capability. This helped EWI provide companies with contacts that can supply commercial solutions to their new product development challenges. By providing assistance in developing supply chain partnerships, EWI helped companies bring their technology to market faster and at a lower cost than they might have been able to do by themselves. Finally, at the most granular level EWI performed dedicated research and development on new manufacturing processes for advanced energy. During discussions with companies participating in advanced energy markets, several technology issues that cut across market segments were identified. To address some of these issues, three crosscutting technology development projects were initiated and completed with Center support. This included reversible welds for batteries

  17. Advanced desiccant materials research

    SciTech Connect

    Czanderna, A.W.; Thomas, T.M.

    1986-05-01

    The long-range goal of this task is to understand the role of surface phenomena in desiccant cooling materials. The background information includes a brief introduction to desiccant cooling systems (DCS) and the role of the desiccant as a system component. The purpose, background, rationale, and long-term technical approach for studying advanced desiccant materials are then treated. Experimental methods for measuring water vapor sorption by desiccants are described, and the rationale is then given for choosing a quartz crystal microbalance (QCM) for measuring sorption isotherms, rates, and cyclic stability. Background information is given about the QCM, including the quartz crystal resonator itself, the support structure for the quartz crystal, and the advantages and limitations of a QCM. The apparatus assembled and placed into operation during CY 1985 is described. The functions of the principal components of the equipment, i.e., the QCM, vacuum system, pressure gauges, residual gas analyzer, constant temperature bath, and data acquisition system, are described as they relate to the water vapor sorption measurements now under way. The criteria for narrowing the potential candidates as advanced desiccant materials for the initial studies are given. Also given is a list of 20 principal candidate materials identified based on the criteria and data available in the literature.

  18. EEG signal features extraction based on fractal dimension.

    PubMed

    Finotello, Francesca; Scarpa, Fabio; Zanon, Mattia

    2015-08-01

    The spread of electroencephalography (EEG) in countless applications has fostered the development of new techniques for extracting synthetic and informative features from EEG signals. However, the definition of an effective feature set depends on the specific problem to be addressed and is currently an active field of research. In this work, we investigated the application of features based on fractal dimension to a problem of sleep identification from EEG data. We demonstrated that features based on fractal dimension, including two novel indices defined in this work, add valuable information to standard EEG features and significantly improve sleep identification performance. PMID:26737209

  19. Pitch features of environmental sounds

    NASA Astrophysics Data System (ADS)

    Yang, Ming; Kang, Jian

    2016-07-01

    A number of soundscape studies have suggested the need for suitable parameters for soundscape measurement, in addition to the conventional acoustic parameters. This paper explores the applicability of pitch features that are often used in music analysis and their algorithms to environmental sounds. Based on the existing alternative pitch algorithms for simulating the perception of the auditory system and simplified algorithms for practical applications in the areas of music and speech, the applicable algorithms have been determined, considering common types of sound in everyday soundscapes. Considering a number of pitch parameters, including pitch value, pitch strength, and percentage of audible pitches over time, different pitch characteristics of various environmental sounds have been shown. Among the four sound categories, i.e. water, wind, birdsongs, and urban sounds, generally speaking, both water and wind sounds have low pitch values and pitch strengths; birdsongs have high pitch values and pitch strengths; and urban sounds have low pitch values and a relatively wide range of pitch strengths.

  20. Epidemiologic features of canine hypothyroidism.

    PubMed

    Milne, K L; Hayes, H M

    1981-01-01

    This study investigates the epidemiologic features of 3,206 dogs diagnosed with hypothyroidism (including myxedema) from 1.1 million dogs seen at 15 veterinary teaching hospitals between March, 1964 and June, 1978. Nine breeds found to be at high-risk for hypothyroidism were: golden retrievers, Doberman pinschers, dachshunds, Shetland sheepdogs, Irish setters, Pomeranians, miniature schnauzers, cocker spaniels, and Airedales. Two breed with a significant deficit of risk were German shepherds and mixed breed (mongrel) dogs. Age risk was greatest among younger dogs of high-risk breeds, further suggesting a genetic component to the etiology of this disease. In contrast, low-risk dogs had increasing relative risk through nine years of age. Spayed female dogs displayed a significantly higher risk when compared to intact females. Though not statistically significant, male castrated dogs had 30% more hypothyroidism compared to their intact counterparts. Among the case series were 91 endocrine and hormone-related neoplasms and 198 other endocrine-related disorders. Further studies linking canine hypothyroidism to other conditions, particularly cancer, could provide valuable insight into human disease experience.

  1. Facial symmetry assessment based on geometric features

    NASA Astrophysics Data System (ADS)

    Xu, Guoping; Cao, Hanqiang

    2015-12-01

    Face image symmetry is an important factor affecting the accuracy of automatic face recognition. Selecting high symmetrical face image could improve the performance of the recognition. In this paper, we proposed a novel facial symmetry evaluation scheme based on geometric features, including centroid, singular value, in-plane rotation angle of face and the structural similarity index (SSIM). First, we calculate the value of the four features according to the corresponding formula. Then, we use fuzzy logic algorithm to integrate the value of the four features into a single number which represents the facial symmetry. The proposed method is efficient and can adapt to different recognition methods. Experimental results demonstrate its effectiveness in improving the robustness of face detection and recognition.

  2. Recent advances in the expression of foreign genes in Pichia pastoris.

    PubMed

    Cregg, J M; Vedvick, T S; Raschke, W C

    1993-08-01

    The Pichia pastoris heterologous gene expression system has been utilized to produce attractive levels of a variety of intracellular and extracellular proteins of interest. Recent advances in our understanding and application of the system have improved its utility even further. These advances include: (1) methods for the construction of P. pastoris strains with multiple copies of AOX1-promoter-driven expression cassettes; (2) mixed-feed culture strategies for high foreign protein volumetric productivity rates; (3) methods to reduce proteolysis of some products in high cell-density culture media; (4) tested procedures for purification of secreted products; and (5) detailed information on the structures of N-linked oligosaccharides on P. pastoris secreted proteins. In this review, these advances along with basic features of the P. pastoris system are described and discussed. PMID:7763913

  3. Decision making on the adoption of advanced medical technology in Taiwan.

    PubMed

    Lan, C F

    1987-01-01

    This paper discusses both the current interest in and approaches to the employment of advanced medical technology in Taiwan. It describes the formation of the national policy, including funding, reimbursement, and regulatory processes, on adopting innovative and expensive medical technologies. Using the case of extracorporeal shockwave lithotripsy (ESWL), the key players who affect organizational decision making on the adoption and diffusion of medical technology have also been analyzed. Finally, it examines some of the salient features of medical technology adoption and assessment in Taiwan, and in other countries which depend heavily upon imported advanced medical technology. It is hoped that an understanding of Taiwan's attempts to use innovative medical technology wisely while incorporating the practice of technology assessment and appropriate policies, will assist other countries with similar conditions to gain maximal benefit from technological advancement.

  4. Utilizing object-oriented design to build advanced optimization strategies with generic implementation

    SciTech Connect

    Eldred, M.S.; Hart, W.E.; Bohnhoff, W.J.; Romero, V.J.; Hutchinson, S.A.; Salinger, A.G.

    1996-08-01

    the benefits of applying optimization to computational models are well known, but their range of widespread application to date has been limited. This effort attempts to extend the disciplinary areas to which optimization algorithms may be readily applied through the development and application of advanced optimization strategies capable of handling the computational difficulties associated with complex simulation codes. Towards this goal, a flexible software framework is under continued development for the application of optimization techniques to broad classes of engineering applications, including those with high computational expense and nonsmooth, nonconvex design space features. Object-oriented software design with C++ has been employed as a tool in providing a flexible, extensible, and robust multidisciplinary toolkit with computationally intensive simulations. In this paper, demonstrations of advanced optimization strategies using the software are presented in the hybridization and parallel processing research areas. Performance of the advanced strategies is compared with a benchmark nonlinear programming optimization.

  5. Features added in new release of SRFYDO - February 2009

    SciTech Connect

    Anderson-cook, Christine M; Klamann, Richard M

    2009-01-01

    Version 2.0 of SRFYDO, released in February 2009, has a number of new features. This document describes these additions and is designed to complement the document 'Calculating System Reliability with SRFYDO: A User Guide' (Los Alamos National Laboratory Technical Report LA-UR 08-06161). The new features include: (1) Reliability Estimates for Combinations of Components - Users can now estimate the reliability of collections of components, such as a sections or sub-systems. This optional feature is activated via a new table, SectionDef, which is used to define names and component associations for the section or sub-system aggregate. If the SectionDef table is present, section plots and tabulated reliabilities will be created during the SRY3 phase. For more details see section 1. (2) Plots of System or Component Reliability Priors - SRFYDO now creates reliability plots for each system (if system priors were given) or each component (if component priors were given) during the SRY1 phase. These plots, written in the directory 'priorPDFs', are provided to help users visualize the impact of their estimates on the final reliability calculation. For more details see section 2. (3) Convenient Exclusion of Lifecycle Covariates - Both GUI and command-line interfaces to SRFYDO now allow the user to exclude one or both of the lifecycle covariates without requiring modification to the spreadsheet. With this capability users can readily explore the effect of adding or removing lifecycle measures on the resulting statistical analysis. Note that excluding a lifecycle covariate is not the same as setting its rate (-b or -c) to zero. For more details see section 3. (4) MCMC Diagnostic Plots - Diagnostic or 'trace' plots may optionally be created for each of the statistical parameters generated during the Monte Carlo phase (SRY2). These plots can help the user determine if (1) appropriate lifecycle variable choices have been made, (2) more sampling iterations, '-i', are required, and

  6. [Plant Spectral Discrimination Based on Phenological Features].

    PubMed

    Zhang, Lei; Zhao, Jian-long; Jia, Kun; Li, Xiao-song

    2015-10-01

    Spectral analysis plays a significant role onplant characteristic identification and mechanism recognition, there were many papers published on the aspects of absorption features in the spectra of chlorophyll and moisture, spectral analysis onvegetation red edge effect, spectra profile feature extraction, spectra profile conversion, vegetation leaf structure and chemical composition impacts on the spectra in past years. However, fewer researches issued on spectral changes caused by plant seasonal changes of life form, chlorophyll, leaf area index. This paper studied on spectral observation of 11 plants of various life form, plant leaf structure and its size, phenological characteristics, they include deciduous forest with broad vertical leaf, needle leaf evergreen forest, needle leaf deciduous forest, deciduous forest with broadflat leaf, high shrub with big leaf, high shrub with little leaf, deciduous forest with broad little leaf, short shrub, meadow, steppe and grass. Field spectral data were observed with SVC-HR768 (Spectra Vista company, USA), the band width covers 350-2 500 nm, spectral resolution reaches 1-4 nm. The features of NDVI, spectral maximum absorption depth in green band, and spectral maximum absorption depth in red band were measured after continuum removal processing, the mean, amplitude and gradient of these features on seasonal change profile were analyzed, meanwhile, separability research on plant spectral feature of growth period and maturation period were compared. The paper presents a calculation method of separability of vegetation spectra which consider feature spatial distances. This index is carried on analysis of the vegetation discrimination. The results show that: the spectral features during plant growth period are easier to distinguish than them during maturation period. With the same features comparison, plant separability of growth period is 3 points higher than it during maturation period. The overall separabilityof vegetation

  7. [Plant Spectral Discrimination Based on Phenological Features].

    PubMed

    Zhang, Lei; Zhao, Jian-long; Jia, Kun; Li, Xiao-song

    2015-10-01

    Spectral analysis plays a significant role onplant characteristic identification and mechanism recognition, there were many papers published on the aspects of absorption features in the spectra of chlorophyll and moisture, spectral analysis onvegetation red edge effect, spectra profile feature extraction, spectra profile conversion, vegetation leaf structure and chemical composition impacts on the spectra in past years. However, fewer researches issued on spectral changes caused by plant seasonal changes of life form, chlorophyll, leaf area index. This paper studied on spectral observation of 11 plants of various life form, plant leaf structure and its size, phenological characteristics, they include deciduous forest with broad vertical leaf, needle leaf evergreen forest, needle leaf deciduous forest, deciduous forest with broadflat leaf, high shrub with big leaf, high shrub with little leaf, deciduous forest with broad little leaf, short shrub, meadow, steppe and grass. Field spectral data were observed with SVC-HR768 (Spectra Vista company, USA), the band width covers 350-2 500 nm, spectral resolution reaches 1-4 nm. The features of NDVI, spectral maximum absorption depth in green band, and spectral maximum absorption depth in red band were measured after continuum removal processing, the mean, amplitude and gradient of these features on seasonal change profile were analyzed, meanwhile, separability research on plant spectral feature of growth period and maturation period were compared. The paper presents a calculation method of separability of vegetation spectra which consider feature spatial distances. This index is carried on analysis of the vegetation discrimination. The results show that: the spectral features during plant growth period are easier to distinguish than them during maturation period. With the same features comparison, plant separability of growth period is 3 points higher than it during maturation period. The overall separabilityof vegetation

  8. Gas fired Advanced Turbine System

    SciTech Connect

    LeCren, R.T.; White, D.J.

    1993-01-01

    The primary objective of the first phase of the Advanced Gas Turbine System (ATS) program was the concept definition of an advanced engine system that meets efficiency and emission goals far exceeding those that can be provided with today`s equipment. The thermal efficiency goal for such an advanced industrial engine was set at 50% some 15 percentage points higher than current equipment levels. Exhaust emissions goals for oxides of nitrogen (NO{sub x}), carbon monoxide (CO), and unburned hydrocarbons (UH) were fixed at 8 parts per million by volume (ppmv), 20 ppmv, and 20 ppmv respectively, corrected to 15% oxygen (O{sub 2}) levels. Other goals had to be addressed; these involved reducing the cost of power produced by 10 percent and improving or maintaining the reliability, availability, and maintainability (RAM) at current levels. This advanced gas turbine was to be fueled with natural gas, and it had to embody features that would allow it bum coal or coal derived fuels.

  9. Kennebunk glacial advance: A reappraisal

    NASA Astrophysics Data System (ADS)

    Smith, Geoffrey W.

    1981-06-01

    Evidence for the Kennebunk glacial advance (readvance) in southwestern Maine is discussed in light of recent geologic mapping. Orientations of glacially produced lineations record the response of ice to major topographic controls and do not indicate glacial readvance. Minor end moraines and large stratified end moraines associated with deformed marine sediments of the Presumpscot Formation occur throughout the southwestern coastal zone. These features outline the general pattern of ice retreat from this part of the coastal zone and suggest that withdrawal of the last ice from southwestern Maine occurred with minor stillstands and local frontal fluctuations but without significant readvance. The Kennebunk glacial advance (readvance) appears to have been one of many local fluctuations of the ice front during general recession, occurring at about 13,200 yr B.P.

  10. Breast Cancer Detection with Reduced Feature Set

    PubMed Central

    Kılıç, Niyazi; Bilgili, Erdem

    2015-01-01

    This paper explores feature reduction properties of independent component analysis (ICA) on breast cancer decision support system. Wisconsin diagnostic breast cancer (WDBC) dataset is reduced to one-dimensional feature vector computing an independent component (IC). The original data with 30 features and reduced one feature (IC) are used to evaluate diagnostic accuracy of the classifiers such as k-nearest neighbor (k-NN), artificial neural network (ANN), radial basis function neural network (RBFNN), and support vector machine (SVM). The comparison of the proposed classification using the IC with original feature set is also tested on different validation (5/10-fold cross-validations) and partitioning (20%–40%) methods. These classifiers are evaluated how to effectively categorize tumors as benign and malignant in terms of specificity, sensitivity, accuracy, F-score, Youden's index, discriminant power, and the receiver operating characteristic (ROC) curve with its criterion values including area under curve (AUC) and 95% confidential interval (CI). This represents an improvement in diagnostic decision support system, while reducing computational complexity. PMID:26078774

  11. Seismic features of Winnipegosis mounds in Saskatchewan

    SciTech Connect

    Gendzwill, D.J.

    1988-07-01

    The Winnipegosis Formation of southern Saskatchewan is characterized by reefs or reeflike mounds in its upper member. Several characteristic features of the mounds permit their identification from seismic-reflection data. These features include reflections from the flanks of the mound, a change in the reflection continuity in the middle and base of the mound, a velocity pullup under the mound, and subsidence of strata over the mound. Dissolution of the salt which surrounds the mounds sometimes occurs, resulting in a drape structure. Some or all of these features may be present at the correct seismic stratigraphic level for Winnipegosis mounds, depending on the local conditions. Subsidence of strata over the mounds indicates compaction and porosity loss from the original mound or possibly the degree of dolomitization or pressure dissolution. Salt-removal features over or adjacent to the mounds indicate fluid movements. Approximate ages can be estimated from stratigraphic thinning and thickening relationships above such features. Complications in identifying Winnipegosis mounds may arise from thin-bed effects if the mounds are not very thick compared to a seismic wavelength. Confusion may also arise from anhydrite, which may encase the mounds or which may form a thick horizontal layer at the tops of the mounds, causing an interfering signal.

  12. Advances in Sleep Studies | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: Sleep Disorders Advances in Sleep Studies Past Issues / Summer 2015 Table of Contents `` ... sleep patterns and possible problems diagnosed What Are Sleep Studies? Sleep studies are tests that measure how ...

  13. Transfer Learning across Feature-Rich Heterogeneous Feature Spaces via Feature-Space Remapping (FSR)

    PubMed Central

    Feuz, Kyle D.; Cook, Diane J.

    2016-01-01

    Transfer learning aims to improve performance on a target task by utilizing previous knowledge learned from source tasks. In this paper we introduce a novel heterogeneous transfer learning technique, Feature- Space Remapping (FSR), which transfers knowledge between domains with different feature spaces. This is accomplished without requiring typical feature-feature, feature instance, or instance-instance co-occurrence data. Instead we relate features in different feature-spaces through the construction of meta-features. We show how these techniques can utilize multiple source datasets to construct an ensemble learner which further improves performance. We apply FSR to an activity recognition problem and a document classification problem. The ensemble technique is able to outperform all other baselines and even performs better than a classifier trained using a large amount of labeled data in the target domain. These problems are especially difficult because in addition to having different feature-spaces, the marginal probability distributions and the class labels are also different. This work extends the state of the art in transfer learning by considering large transfer across dramatically different spaces. PMID:27019767

  14. Nonlinear features for product inspection

    NASA Astrophysics Data System (ADS)

    Talukder, Ashit; Casasent, David P.

    1999-03-01

    Classification of real-time X-ray images of randomly oriented touching pistachio nuts is discussed. The ultimate objective is the development of a system for automated non-invasive detection of defective product items on a conveyor belt. We discuss the extraction of new features that allow better discrimination between damaged and clean items (pistachio nuts). This feature extraction and classification stage is the new aspect of this paper; our new maximum representation and discriminating feature (MRDF) extraction method computes nonlinear features that are used as inputs to a new modified k nearest neighbor classifier. In this work, the MRDF is applied to standard features (rather than iconic data). The MRDF is robust to various probability distributions of the input class and is shown to provide good classification and new ROC (receiver operating characteristic) data.

  15. Gestures and Insight in Advanced Mathematical Thinking

    ERIC Educational Resources Information Center

    Yoon, Caroline; Thomas, Michael O. J.; Dreyfus, Tommy

    2011-01-01

    What role do gestures play in advanced mathematical thinking? We argue that the role of gestures goes beyond merely communicating thought and supporting understanding--in some cases, gestures can help generate new mathematical insights. Gestures feature prominently in a case study of two participants working on a sequence of calculus activities.…

  16. Ford Partnership for Advanced Studies (Ford PAS)

    ERIC Educational Resources Information Center

    Carrier, Cheryl

    2006-01-01

    This article features the Ford Partnership for Advanced Studies (Ford PAS) program that helps students gain knowledge about real-life business issues. Ford PAS is an educational program that combines college-prep academics with the critical 21st century skills students will need to succeed in college and in the workplace. The Ford PAS program uses…

  17. Identifying Advanced Technologies for Education's Future.

    ERIC Educational Resources Information Center

    Moore, Gwendolyn B.; Yin, Robert K.

    A study to determine how three advanced technologies might be applied to the needs of special education students helped inspire the development of a new method for identifying such applications. This new method, named the "Hybrid Approach," combines features of the two traditional methods: technology-push and demand-pull. Technology-push involves…

  18. Article Including Environmental Barrier Coating System

    NASA Technical Reports Server (NTRS)

    Lee, Kang N. (Inventor)

    2015-01-01

    An enhanced environmental barrier coating for a silicon containing substrate. The enhanced barrier coating may include a bond coat doped with at least one of an alkali metal oxide and an alkali earth metal oxide. The enhanced barrier coating may include a composite mullite bond coat including BSAS and another distinct second phase oxide applied over said surface.

  19. Working towards integrated community care for older people: empowering organisational features from a professional perspective.

    PubMed

    Janssen, Bienke M; Snoeren, Miranda W C; Van Regenmortel, Tine; Abma, Tineke A

    2015-01-01

    Although multi-disciplinary cooperation between professionals is a prerequisite to provide integrated care in the community, this seems hard to realise in practice. Yet, little is known about the experiences of professionals who implement it nor about the organisational features professionals identify as empowering during this cooperation process. Therefore, a case study of a multi-disciplinary geriatric team was performed. The data-collection included observations of meetings, in-depth interviews and focus groups with professionals (N = 12). Data were analysed inductively and related to the three organisational levels within the model of organisational empowerment of Peterson and Zimmerman. Signs of empowering organisational features on the intraorganisational level were mutual trust and clear working routines. On the interorganisational level important features included improved linkages between participating organisations and increased insight into each other's tasks. Tensions occurred relating to the inter- and the extraorganisational level. Professionals felt that the commitment of the management of involved organisations should be improved just as the capacity of the team to influence (local) policy. It is recommended that policymakers should not determine the nature of professional cooperation in advance, but to leave that to the local context as well as to the judgement of involved professionals. PMID:25445110

  20. The relationship between 2D static features and 2D dynamic features used in gait recognition

    NASA Astrophysics Data System (ADS)

    Alawar, Hamad M.; Ugail, Hassan; Kamala, Mumtaz; Connah, David

    2013-05-01

    In most gait recognition techniques, both static and dynamic features are used to define a subject's gait signature. In this study, the existence of a relationship between static and dynamic features was investigated. The correlation coefficient was used to analyse the relationship between the features extracted from the "University of Bradford Multi-Modal Gait Database". This study includes two dimensional dynamic and static features from 19 subjects. The dynamic features were compromised of Phase-Weighted Magnitudes driven by a Fourier Transform of the temporal rotational data of a subject's joints (knee, thigh, shoulder, and elbow). The results concluded that there are eleven pairs of features that are considered significantly correlated with (p<0.05). This result indicates the existence of a statistical relationship between static and dynamics features, which challenges the results of several similar studies. These results bare great potential for further research into the area, and would potentially contribute to the creation of a gait signature using latent data.

  1. The Advanced Solid Rocket Motor

    NASA Technical Reports Server (NTRS)

    Mitchell, Royce E.

    1992-01-01

    The paper describes the Advanced Solid Rocket Motor (ASRM) that is being developed to replace, in 1997, the Redesigned Solid Rocket Motor which currently boosts the Space Shuttle. The ASRM will contain features to improve motor safety (fewer potential leak paths, improved seal materials, stronger case material, and fewer nozzle and case joints), an improved ignition system using through-bulkhead initiators, and highly reproducible manufacturing and inspection techniques with a large number of automated procedures. The ASRM will be able to deliver 12,000 lbs greater payloads to any given orbit of the Shuttle. There are also environmental improvements, realized by waste propellant recovery.

  2. Modern Advances in Ablative TPS

    NASA Technical Reports Server (NTRS)

    Venkatapathy, Ethiraj

    2013-01-01

    Topics covered include: Physics of Hypersonic Flow and TPS Considerations. Destinations, Missions and Requirements. State of the Art Thermal Protection Systems Capabilities. Modern Advances in Ablative TPS. Entry Systems Concepts. Flexible TPS for Hypersonic Inflatable Aerodynamic Decelerators. Conformal TPS for Rigid Aeroshell. 3-D Woven TPS for Extreme Entry Environment. Multi-functional Carbon Fabric for Mechanically Deployable.

  3. Advances in genetics. Volume 23

    SciTech Connect

    Caspari, E.W.; Scandalios, J.G.

    1985-01-01

    This book presents articles on genetics and the advances made in this field. Topics covered include the following: recovery, repair, and mutagenesis in Schizosaccharomyces pombe; gene transfer in fungi; Y chromosome function and spermatogenesis in Drosophila hydei; recent developments in population genetics; and genetics, cytology and evolution of Gossypium.

  4. Early Childhood Assessment: Recent Advances.

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Greathouse, Dan

    As concern about the developmental progress of preschoolers has increased, the number of assessment instruments available has expanded. This paper reviews recent advances in early childhood assessment and evaluation, and describes several screening and assessment instruments. Varying information is presented for each test, but may include a…

  5. Advanced solid propellant motor insulation

    NASA Technical Reports Server (NTRS)

    Smith, P. L.; Russ, R. F.

    1972-01-01

    An advanced lightweight insulation system suitable for use in long duration, low pressure planetary orbiter-type motor applications was developed. Experiments included the screening of various filler and binder materials with optimization studies combining the best of each. Small scale test motor data were used to judge the degree of success.

  6. French on the Advanced Level.

    ERIC Educational Resources Information Center

    Pawlik, Teresa Wilkinson

    1969-01-01

    Presented in this article is an outline of some of the special interest course work included in the curriculum guidelines being developed in the Atlanta Public Schools System for advanced secondary school French classes. Titles of the audiolingually-oriented courses described are--(1) "Teenagers and Teenage Life in France Today," (2) "The Arts in…

  7. Advanced liner-cooling techniques for gas turbine combustors

    NASA Technical Reports Server (NTRS)

    Norgren, C. T.; Riddlebaugh, S. M.

    1985-01-01

    Component research for advanced small gas turbine engines is currently underway at the NASA Lewis Research Center. As part of this program, a basic reverse-flow combustor geometry was being maintained while different advanced liner wall cooling techniques were investigated. Performance and liner cooling effectiveness of the experimental combustor configuration featuring counter-flow film-cooled panels is presented and compared with two previously reported combustors featuring: splash film-cooled liner walls; and transpiration cooled liner walls (Lamilloy).

  8. Oxidation of advanced steam turbine alloys

    SciTech Connect

    Holcomb, G.R.; Covino, B.S., Jr.; Bullard, S.J.; Ziomek-Moroz, M.

    2006-03-01

    Advanced or ultra supercritical (USC) steam power plants offer the promise of higher efficiencies and lower emissions. Current goals of the U.S. Department of Energy’s Advanced Power Systems Initiatives include coal generation at 60% efficiency, which would require steam temperatures of up to 760°C. This research examines the steamside oxidation of advanced alloys for use in USC systems, with emphasis placed on alloys for high- and intermediate-pressure turbine sections.

  9. Advanced Chemistry Basins Model

    SciTech Connect

    William Goddard; Mario Blanco; Lawrence Cathles; Paul Manhardt; Peter Meulbroek; Yongchun Tang

    2002-11-10

    The DOE-funded Advanced Chemistry Basin model project is intended to develop a public domain, user-friendly basin modeling software under PC or low end workstation environment that predicts hydrocarbon generation, expulsion, migration and chemistry. The main features of the software are that it will: (1) afford users the most flexible way to choose or enter kinetic parameters for different maturity indicators; (2) afford users the most flexible way to choose or enter compositional kinetic parameters to predict hydrocarbon composition (e.g., gas/oil ratio (GOR), wax content, API gravity, etc.) at different kerogen maturities; (3) calculate the chemistry, fluxes and physical properties of all hydrocarbon phases (gas, liquid and solid) along the primary and secondary migration pathways of the basin and predict the location and intensity of phase fractionation, mixing, gas washing, etc.; and (4) predict the location and intensity of de-asphaltene processes. The project has be operative for 36 months, and is on schedule for a successful completion at the end of FY 2003.

  10. Recent advances in sarcoidosis.

    PubMed

    Morgenthau, Adam S; Iannuzzi, Michael C

    2011-01-01

    Sarcoidosis, a systemic granulomatous disease of undetermined etiology, is characterized by a variable clinical presentation and course. During the past decade, advances have been made in the study of sarcoidosis. The multicenter ACCESS (A Case Control Etiologic Study of Sarcoidosis) trial recruited > 700 subjects with newly diagnosed sarcoidosis and matched control subjects. Investigators were unable to identify a single cause of sarcoidosis, but ACCESS paved the way for subsequent etiologic studies. The Mycobacterium tuberculosis catalase-peroxidase protein has been identified as a potential sarcoidosis antigen. Genetic aspects of the disease have been elucidated further. Genome-wide scans have identified candidate genes. Gene expression analyses have defined cytokine dysregulation in sarcoidosis more clearly. Although the criteria for diagnosis have not changed, sarcoidosis remains a diagnosis of exclusion best supported by a tissue biopsy specimen that demonstrates noncaseating granulomas in a patient with compatible clinical and radiologic features of the disease. Endobronchial ultrasound-guided transbronchial needle aspiration of mediastinal lymph nodes has facilitated diagnosis, often eliminating the need for more invasive procedures, such as mediastinoscopy. PET scanning has proven valuable in locating occult sites of active disease. Currently, no reliable prognostic biomarkers have been identified. The tumor necrosis factor inhibitors, a relatively new class of agents, have been used in patients with refractory disease. It is unclear whether phosphodiesterase-5 inhibitors, prostaglandin analogs, or endothelin antagonists should be used for the treatment of sarcoidosis-associated pulmonary hypertension. PMID:21208877

  11. Clinical features of sporadic fatal insomnia.

    PubMed

    Barash, Jed A

    2009-01-01

    Recent advances in neuropathology, genotyping, and physiochemical characterization of proteins have allowed for the classification and verification of MM2-thalamic Creutzfeldt-Jakob disease (CJD). CJD is a fatal neurodegenerative illness belonging to the transmissible spongiform encephalopathies, also known as prion diseases. Sporadic CJD is generally classified by the genotype at codon 129 of the prion protein gene and the distinct physiochemical features of the pathologic prion protein (PrP(sc)). The entity is characterized by methionine homozygosity at codon 129, type 2 PrP(sc), and, primarily, thalamic pathology (MM2-thalamic CJD). It shares clinical and pathologic similarities with the genetic prion disorder fatal familial insomnia; the MM2-thalamic phenotype has therefore been called sporadic fatal insomnia (SFI). SFI may also present like other neurodegenerative diseases, and common diagnostic findings that are seen in other forms of sporadic CJD may be absent.

  12. Feature issue introduction: biophotonic materials and applications

    PubMed Central

    Lee, Kwang-Sup; Andraud, Chantal; Tamada, Kaoru; Sokolov, Konstantin; Kotz, Kenneth T.; Zheng, Gang

    2016-01-01

    Biophotonics can be defined as the interplay of light and biological matter. The percolation of new optical technology into the realm of biology has literally shed new light into the inner workings of biological systems. This has revealed new applications for optics in biology. In a parallel trend, biomolecules have been investigated for their optical applications. Materials are playing a central role in the development of biophotonics. New materials, fabrication methods, and structures are enabling new biosensors, contrast agents, imaging strategies, and assay methods. Similarly, biologic materials themselves can be used in photonic devices. In this context, two open-access, rapid-publication journals from The Optical Society of America (OSA), Optical Materials Express and Biomedical Optics Express, will publish a joint feature issue covering advances in biophotonics materials. PMID:27231644

  13. Beam Optics Analysis - An Advanced 3D Trajectory Code

    SciTech Connect

    Ives, R. Lawrence; Bui, Thuc; Vogler, William; Neilson, Jeff; Read, Mike; Shephard, Mark; Bauer, Andrew; Datta, Dibyendu; Beal, Mark

    2006-01-03

    Calabazas Creek Research, Inc. has completed initial development of an advanced, 3D program for modeling electron trajectories in electromagnetic fields. The code is being used to design complex guns and collectors. Beam Optics Analysis (BOA) is a fully relativistic, charged particle code using adaptive, finite element meshing. Geometrical input is imported from CAD programs generating ACIS-formatted files. Parametric data is inputted using an intuitive, graphical user interface (GUI), which also provides control of convergence, accuracy, and post processing. The program includes a magnetic field solver, and magnetic information can be imported from Maxwell 2D/3D and other programs. The program supports thermionic emission and injected beams. Secondary electron emission is also supported, including multiple generations. Work on field emission is in progress as well as implementation of computer optimization of both the geometry and operating parameters. The principle features of the program and its capabilities are presented.

  14. Beam Optics Analysis — An Advanced 3D Trajectory Code

    NASA Astrophysics Data System (ADS)

    Ives, R. Lawrence; Bui, Thuc; Vogler, William; Neilson, Jeff; Read, Mike; Shephard, Mark; Bauer, Andrew; Datta, Dibyendu; Beal, Mark

    2006-01-01

    Calabazas Creek Research, Inc. has completed initial development of an advanced, 3D program for modeling electron trajectories in electromagnetic fields. The code is being used to design complex guns and collectors. Beam Optics Analysis (BOA) is a fully relativistic, charged particle code using adaptive, finite element meshing. Geometrical input is imported from CAD programs generating ACIS-formatted files. Parametric data is inputted using an intuitive, graphical user interface (GUI), which also provides control of convergence, accuracy, and post processing. The program includes a magnetic field solver, and magnetic information can be imported from Maxwell 2D/3D and other programs. The program supports thermionic emission and injected beams. Secondary electron emission is also supported, including multiple generations. Work on field emission is in progress as well as implementation of computer optimization of both the geometry and operating parameters. The principle features of the program and its capabilities are presented.

  15. pFUnit 3.0 Tutorial Advanced

    NASA Technical Reports Server (NTRS)

    Clune, Tom

    2014-01-01

    This tutorial will introduce Fortran developers to unit-testing and test-driven development (TDD) using pFUnit. As with other unit-testing frameworks, pFUnit, simplifies the process of writing, collecting, and executing tests while providing clear diagnostic messages for failing tests. pFUnit specifically targets the development of scientific-technical software written in Fortran and includes customized features such as: assertions for multi-dimensional arrays, distributed (MPI) and thread-based (OpenMP) parallellism, and flexible parameterized tests.These sessions will include numerous examples and hands-on exercises that gradually build in complexity. Attendees are expected to have working knowledge of F90, but familiarity with object-oriented syntax in F2003 and MPI will be of benefit for the more advanced examples. By the end of the tutorial the audience should feel comfortable in applying pFUnit within their own development environment.

  16. Advance finite element modeling of rotor blade aeroelasticity

    NASA Technical Reports Server (NTRS)

    Straub, F. K.; Sangha, K. B.; Panda, B.

    1994-01-01

    An advanced beam finite element has been developed for modeling rotor blade dynamics and aeroelasticity. This element is part of the Element Library of the Second Generation Comprehensive Helicopter Analysis System (2GCHAS). The element allows modeling of arbitrary rotor systems, including bearingless rotors. It accounts for moderately large elastic deflections, anisotropic properties, large frame motion for maneuver simulation, and allows for variable order shape functions. The effects of gravity, mechanically applied and aerodynamic loads are included. All kinematic quantities required to compute airloads are provided. In this paper, the fundamental assumptions and derivation of the element matrices are presented. Numerical results are shown to verify the formulation and illustrate several features of the element.

  17. Advanced optic fabrication using ultrafast laser radiation

    NASA Astrophysics Data System (ADS)

    Taylor, Lauren L.; Qiao, Jun; Qiao, Jie

    2016-03-01

    Advanced fabrication and finishing techniques are desired for freeform optics and integrated photonics. Methods including grinding, polishing and magnetorheological finishing used for final figuring and polishing of such optics are time consuming, expensive, and may be unsuitable for complex surface features while common photonics fabrication techniques often limit devices to planar geometries. Laser processing has been investigated as an alternative method for optic forming, surface polishing, structure writing, and welding, as direct tuning of laser parameters and flexible beam delivery are advantageous for complex freeform or photonics elements and material-specific processing. Continuous wave and pulsed laser radiation down to the nanosecond regime have been implemented to achieve nanoscale surface finishes through localized material melting, but the temporal extent of the laser-material interaction often results in the formation of a sub-surface heat affected zone. The temporal brevity of ultrafast laser radiation can allow for the direct vaporization of rough surface asperities with minimal melting, offering the potential for smooth, final surface quality with negligible heat affected material. High intensities achieved in focused ultrafast laser radiation can easily induce phase changes in the bulk of materials for processing applications. We have experimentally tested the effectiveness of ultrafast laser radiation as an alternative laser source for surface processing of monocrystalline silicon. Simulation of material heating associated with ultrafast laser-material interaction has been performed and used to investigate optimized processing parameters including repetition rate. The parameter optimization process and results of experimental processing will be presented.

  18. Advanced Potential Energy Surfaces for Molecular Simulation.

    PubMed

    Albaugh, Alex; Boateng, Henry A; Bradshaw, Richard T; Demerdash, Omar N; Dziedzic, Jacek; Mao, Yuezhi; Margul, Daniel T; Swails, Jason; Zeng, Qiao; Case, David A; Eastman, Peter; Wang, Lee-Ping; Essex, Jonathan W; Head-Gordon, Martin; Pande, Vijay S; Ponder, Jay W; Shao, Yihan; Skylaris, Chris-Kriton; Todorov, Ilian T; Tuckerman, Mark E; Head-Gordon, Teresa

    2016-09-22

    Advanced potential energy surfaces are defined as theoretical models that explicitly include many-body effects that transcend the standard fixed-charge, pairwise-additive paradigm typically used in molecular simulation. However, several factors relating to their software implementation have precluded their widespread use in condensed-phase simulations: the computational cost of the theoretical models, a paucity of approximate models and algorithmic improvements that can ameliorate their cost, underdeveloped interfaces and limited dissemination in computational code bases that are widely used in the computational chemistry community, and software implementations that have not kept pace with modern high-performance computing (HPC) architectures, such as multicore CPUs and modern graphics processing units (GPUs). In this Feature Article we review recent progress made in these areas, including well-defined polarization approximations and new multipole electrostatic formulations, novel methods for solving the mutual polarization equations and increasing the MD time step, combining linear-scaling electronic structure methods with new QM/MM methods that account for mutual polarization between the two regions, and the greatly improved software deployment of these models and methods onto GPU and CPU hardware platforms. We have now approached an era where multipole-based polarizable force fields can be routinely used to obtain computational results comparable to state-of-the-art density functional theory while reaching sampling statistics that are acceptable when compared to that obtained from simpler fixed partial charge force fields.

  19. Advanced Stirling conversion systems for terrestrial applications

    SciTech Connect

    Shaltens, R.K.

    1987-01-01

    Sandia National Laboratories (SNLA) is developing heat engines for terrestrial Solar distributed Heat Receivers. SNLA has identified the Stirling to be one of the most promising candidates for the terrestrial applications. The free-piston Stirling engine (FPSE) has the potential to meet the DOE goals for both performance and cost. Free-piston Stirling activities which are directed toward a dynamic power source for the space application are being conducted. Space power system requirements include high efficiency, very long life, high reliability and low vibration. The FPSE has the potential for future high power space conversion systems, either solar or nuclear powered. Generic free-piston technology is currently being developed for use with a residential heat pump under an Interagency Agreement. Also, an overview is presented of proposed conceptual designs for the Advanced Stirling Conversion System (ASCS) using a free-piston Stirling engine and a liquid metal heat pipe receiver. Power extraction includes both a linear alternator and hydraulic output capable of delivering approximately 25 kW of electrical power to the electric utility grid. Target cost of the engine/alternator is 300 dollars per kilowatt at a manufacturing rate of 10,000 units per year. The design life of the ASCS is 60,000 h (30 y) with an engine overhaul at 40,000 h (20 y). Also discussed are the key features and characteristics of the ASCS conceptual designs.

  20. Advanced Potential Energy Surfaces for Molecular Simulation.

    PubMed

    Albaugh, Alex; Boateng, Henry A; Bradshaw, Richard T; Demerdash, Omar N; Dziedzic, Jacek; Mao, Yuezhi; Margul, Daniel T; Swails, Jason; Zeng, Qiao; Case, David A; Eastman, Peter; Wang, Lee-Ping; Essex, Jonathan W; Head-Gordon, Martin; Pande, Vijay S; Ponder, Jay W; Shao, Yihan; Skylaris, Chris-Kriton; Todorov, Ilian T; Tuckerman, Mark E; Head-Gordon, Teresa

    2016-09-22

    Advanced potential energy surfaces are defined as theoretical models that explicitly include many-body effects that transcend the standard fixed-charge, pairwise-additive paradigm typically used in molecular simulation. However, several factors relating to their software implementation have precluded their widespread use in condensed-phase simulations: the computational cost of the theoretical models, a paucity of approximate models and algorithmic improvements that can ameliorate their cost, underdeveloped interfaces and limited dissemination in computational code bases that are widely used in the computational chemistry community, and software implementations that have not kept pace with modern high-performance computing (HPC) architectures, such as multicore CPUs and modern graphics processing units (GPUs). In this Feature Article we review recent progress made in these areas, including well-defined polarization approximations and new multipole electrostatic formulations, novel methods for solving the mutual polarization equations and increasing the MD time step, combining linear-scaling electronic structure methods with new QM/MM methods that account for mutual polarization between the two regions, and the greatly improved software deployment of these models and methods onto GPU and CPU hardware platforms. We have now approached an era where multipole-based polarizable force fields can be routinely used to obtain computational results comparable to state-of-the-art density functional theory while reaching sampling statistics that are acceptable when compared to that obtained from simpler fixed partial charge force fields. PMID:27513316

  1. Advanced isotope separation

    SciTech Connect

    Not Available

    1982-05-04

    The Study Group briefly reviewed the technical status of the three Advanced Isotope Separation (AIS) processes. It also reviewed the evaluation work that has been carried out by DOE's Process Evaluation Board (PEB) and the Union Carbide Corporation-Nuclear Division (UCCND). The Study Group briefly reviewed a recent draft assessment made for DOE staff of the nonproliferation implications of the AIS technologies. The staff also very briefly summarized the status of GCEP and Advanced Centrifuge development. The Study Group concluded that: (1) there has not been sufficient progress to provide a firm scientific, technical or economic basis on which to select one of the three competing AIS processes for full-scale engineering development at this time; and (2) however, should budgetary restraints or other factors force such a selection, we believe that the evaluation process that is being carried out by the PEB provides the best basis available for making a decision. The Study Group recommended that: (1) any decisions on AIS processes should include a comparison with gas centrifuge processes, and should not be made independently from the plutonium isotope program; (2) in evaluating the various enrichment processes, all applicable costs (including R and D and sales overhead) and an appropriate discounting approach should be included in order to make comparisons on a private industry basis; (3) if the three AIS programs continue with limited resources, the work should be reoriented to focus only on the most pressing technical problems; and (4) if a decision is made to develop the Atomic Vapor Laser Isotope Separation process, the solid collector option should be pursued in parallel to alleviate the potential program impact of liquid collector thermal control problems.

  2. Advances in Male Contraception

    PubMed Central

    Page, Stephanie T.; Amory, John K.; Bremner, William J.

    2008-01-01

    Despite significant advances in contraceptive options for women over the last 50 yr, world population continues to grow rapidly. Scientists and activists alike point to the devastating environmental impacts that population pressures have caused, including global warming from the developed world and hunger and disease in less developed areas. Moreover, almost half of all pregnancies are still unwanted or unplanned. Clearly, there is a need for expanded, reversible, contraceptive options. Multicultural surveys demonstrate the willingness of men to participate in contraception and their female partners to trust them to do so. Notwithstanding their paucity of options, male methods including vasectomy and condoms account for almost one third of contraceptive use in the United States and other countries. Recent international clinical research efforts have demonstrated high efficacy rates (90–95%) for hormonally based male contraceptives. Current barriers to expanded use include limited delivery methods and perceived regulatory obstacles, which stymie introduction to the marketplace. However, advances in oral and injectable androgen delivery are cause for optimism that these hurdles may be overcome. Nonhormonal methods, such as compounds that target sperm motility, are attractive in their theoretical promise of specificity for the reproductive tract. Gene and protein array technologies continue to identify potential targets for this approach. Such nonhormonal agents will likely reach clinical trials in the near future. Great strides have been made in understanding male reproductive physiology; the combined efforts of scientists, clinicians, industry and governmental funding agencies could make an effective, reversible, male contraceptive an option for family planning over the next decade. PMID:18436704

  3. Established Designs For Advanced Ground Based Astronomical Telescopes In The 1-meter To 4-meter Domain

    NASA Astrophysics Data System (ADS)

    Hull, Anthony B.; Barentine, J.; Legters, S.

    2012-01-01

    The same technology and analytic approaches that led to cost-effective unmitigated successes for the spaceborne Kepler and WISE telescopes are now being applied to meter-class to 4-meter-class ground telescopes, providing affordable solutions to ground astronomy, with advanced features as needed for the application. The range of optical and mechanical performance standards and features that can be supplied for ground astronomy shall be described. Both classical RC designs, as well as unobscured designs are well represented in the IOS design library, allowing heritage designs for both night time and day time operations, the latter even in the proximity of the sun. In addition to discussing this library of mature features, we will also describe a process for working with astronomers early in the definition process to provide the best-value solution. Solutions can include remote operation and astronomical data acquisition and transmission.

  4. Isotope Separation and Advanced Manufacturing Technology. ISAM semiannual report, Volume 3, Number 1, October 1993--March 1994

    SciTech Connect

    Carpenter, J.; Kan, T.

    1994-10-01

    This is the fourth issue of a semiannual report for the Isotope Separation and Advanced Materials Manufacturing (ISAM) Technology Program at Lawrence Livermore National Laboratory. Primary objectives include: (I) the Uranium Atomic Vapor Laser Isotope Separation (UAVLIS) process, which is being developed and prepared for deployment as an advanced uranium enrichment capability; (II) Advanced manufacturing technologies, which include industrial laser and E-beam material processing and new manufacturing technologies for uranium, plutonium, and other strategically important materials in support of DOE and other national applications. This report features progress in the ISAM Program from October 1993 through March 1994. Selected papers were indexed separately for inclusion in the Energy Science and Technology Database.

  5. Feature

    NASA Astrophysics Data System (ADS)

    2011-01-01

    Shi Changxu, former vice-president of NSFC wins Top Prize of National Science and Technology Award of China Both China and the world materials community have greatly benefitted from his service, by RPH Chang Shi Changxu—a great teacher and mentor for materials scientists, by Gaoqing Max Lu A bright example for all of us—Professor Shi Changxu, by Wei Gao Professor Shi Changxu—The Giant Materials Scientist of China, by Wuzong Zhou Congratulations to Academician Changxu Shi on the Occasion of His Winning the 2010 Chinese Science & Technology Grand Prize, by Ju Li, Kai Chen, Zhiwei Shan, Guanjun Qiao, Jun Sun and Evan Ma Materials—the foundation for technology revolutions, by Zhong Lin Wang

  6. Composite Pressure Vessel Including Crack Arresting Barrier

    NASA Technical Reports Server (NTRS)

    DeLay, Thomas K. (Inventor)

    2013-01-01

    A pressure vessel includes a ported fitting having an annular flange formed on an end thereof and a tank that envelopes the annular flange. A crack arresting barrier is bonded to and forming a lining of the tank within the outer surface thereof. The crack arresting barrier includes a cured resin having a post-curing ductility rating of at least approximately 60% through the cured resin, and further includes randomly-oriented fibers positioned in and throughout the cured resin.

  7. Clinicopathologic Features of Pediatric Oligodendrogliomas

    PubMed Central

    Rodriguez, Fausto J.; Tihan, Tarik; Lin, Doris; McDonald, William; Nigro, Janice; Feuerstein, Burt; Jackson, Sadhana; Cohen, Kenneth; Burger, Peter C.

    2015-01-01

    Oligodendrogliomas are an important adult form of diffuse gliomas with a distinctive clinical and genetic profile. Histologically similar tumors occurring rarely in children are incompletely characterized. We studied 50 patients with oligodendrogliomas (median age at diagnosis 8 y, range 7mo to 20 y). Tumors resembling dysembryoplastic neuroepithelial tumors or pilocytic astrocytomas or those having a “mixed” histology were excluded. Tumors at first diagnosis were low grade (n=38) or anaplastic (n=12). Histologic features included uniform round cells with perinuclear halos (100%), secondary structures (predominantly perineuronal satellitosis) (90%), calcifications (46%), and microcysts (44%). Sequential surgical specimens were obtained in 8 low-grade oligodendroglioma patients, with only 1 progressing to anaplasia. Studies for 1p19q performed in 40 cases demonstrated intact 1p19q loci in 29 (73%), 1p19q codeletion in 10 (25%), and 1p deletion with intact 19q in 1 (2%). Except for 2 young patients (3 and 11 y of age), patients with 1p19q codeletion were older than 16 years at diagnosis. Mutant IDH1 (R132H) protein immunohistochemistry was positive in 4 (of 22) (18%) cases, 3 of which also had 1p19q codeletion, whereas 1p19q status was not available on the fourth case. There was a nonsignificant trend for worse overall survival in grade III tumors, but no significant association with age, extent of resection, or 1p19q status. In summary, oligodendrogliomas with classic histology occur in the pediatric population but lack 1p19q codeletion and IDH1 (R132H) mutations in most instances. They are predominantly low grade, recur/clinically progress in a subset, but demonstrate a relatively low frequency of histologic progression. PMID:24805856

  8. Emerging features of ER resident J-proteins in plants.

    PubMed

    Ohta, Masaru; Takaiwa, Fumio

    2014-01-01

    J-proteins are co-chaperone components of the HSP70 system. J-proteins stimulate Hsp70ATPase activity, which is responsible for stabilizing the interaction of Hsp70 with client proteins. J-proteins are localized in various intracellular compartments including the cytoplasm, mitochondria and endoplasmic reticulum (ER). Five types of ER resident J-proteins (ERdjs) have been found in plants (P58, ERdj2, ERdj2A, ERdj3B and ERdj7). Rice OsERdj3A is located in the vacuole and protein storage vacuoles (PSV, PB-II) under conditions of ER stress. J-proteins that are localized to the vacuole or lysosome are not found in mammals and yeast, suggesting that the presence of OsERdj3A in the vacuole is plant-specific and one of the features unique to plant ERdjs. In this review, we summarize the current state of knowledge and recent research advancements regarding plant ERdjs, and compare mammalian and yeast ERdjs with plant ERdjs. PMID:25763480

  9. Acquisition and processing of advanced sensor data for ERW and UXO detection and classification

    NASA Astrophysics Data System (ADS)

    Schultz, Gregory M.; Keranen, Joe; Miller, Jonathan S.; Shubitidze, Fridon

    2014-06-01

    The remediation of explosive remnants of war (ERW) and associated unexploded ordnance (UXO) has seen improvements through the injection of modern technological advances and streamlined standard operating procedures. However, reliable and cost-effective detection and geophysical mapping of sites contaminated with UXO such as cluster munitions, abandoned ordnance, and improvised explosive devices rely on the ability to discriminate hazardous items from metallic clutter. In addition to anthropogenic clutter, handheld and vehicle-based metal detector systems are plagued by natural geologic and environmental noise in many post conflict areas. We present new and advanced electromagnetic induction (EMI) technologies including man-portable and towed EMI arrays and associated data processing software. While these systems feature vastly different form factors and transmit-receive configurations, they all exhibit several fundamental traits that enable successful classification of EMI anomalies. Specifically, multidirectional sampling of scattered magnetic fields from targets and corresponding high volume of unique data provide rich information for extracting useful classification features for clutter rejection analysis. The quality of classification features depends largely on the extent to which the data resolve unique physics-based parameters. To date, most of the advanced sensors enable high quality inversion by producing data that are extremely rich in spatial content through multi-angle illumination and multi-point reception.

  10. Advances in speech processing

    NASA Astrophysics Data System (ADS)

    Ince, A. Nejat

    1992-10-01

    The field of speech processing is undergoing a rapid growth in terms of both performance and applications and this is fueled by the advances being made in the areas of microelectronics, computation, and algorithm design. The use of voice for civil and military communications is discussed considering advantages and disadvantages including the effects of environmental factors such as acoustic and electrical noise and interference and propagation. The structure of the existing NATO communications network and the evolving Integrated Services Digital Network (ISDN) concept are briefly reviewed to show how they meet the present and future requirements. The paper then deals with the fundamental subject of speech coding and compression. Recent advances in techniques and algorithms for speech coding now permit high quality voice reproduction at remarkably low bit rates. The subject of speech synthesis is next treated where the principle objective is to produce natural quality synthetic speech from unrestricted text input. Speech recognition where the ultimate objective is to produce a machine which would understand conversational speech with unrestricted vocabulary, from essentially any talker, is discussed. Algorithms for speech recognition can be characterized broadly as pattern recognition approaches and acoustic phonetic approaches. To date, the greatest degree of success in speech recognition has been obtained using pattern recognition paradigms. It is for this reason that the paper is concerned primarily with this technique.

  11. Advanced Liquid Feed Experiment

    NASA Astrophysics Data System (ADS)

    Distefano, E.; Noll, C.

    1993-06-01

    The Advanced Liquid Feed Experiment (ALFE) is a Hitchhiker experiment flown on board the Shuttle of STS-39 as part of the Space Test Payload-1 (STP-1). The purpose of ALFE is to evaluate new propellant management components and operations under the low gravity flight environment of the Space Shuttle for eventual use in an advanced spacecraft feed system. These components and operations include an electronic pressure regulator, an ultrasonic flowmeter, an ultrasonic point sensor gage, and on-orbit refill of an auxiliary propellant tank. The tests are performed with two transparent tanks with dyed Freon 113, observed by a camera and controlled by ground commands and an on-board computer. Results show that the electronic pressure regulator provides smooth pressure ramp-up, sustained pressure control, and the flexibility to change pressure settings in flight. The ultrasonic flowmeter accurately measures flow and detects gas ingestion. The ultrasonic point sensors function well in space, but not as a gage during sustained low-gravity conditions, as they, like other point gages, are subject to the uncertainties of propellant geometry in a given tank. Propellant transfer operations can be performed with liquid-free ullage equalization at a 20 percent fill level, gas-free liquid transfer from 20-65 percent fill level, minimal slosh, and can be automated.

  12. Advances in Capsule Endoscopy

    PubMed Central

    Scott, Ryan

    2015-01-01

    Wireless video capsule endoscopy (VCE) is a minimally invasive technology that has revolutionized the approach to small intestinal disease investigation and management. Designed primarily to provide diagnostic imaging of the small intestine, VCE is used predominantly for obscure gastrointestinal bleeding and suspected Crohn’s disease; however, numerous other indications have been established, including the assessment of celiac disease, investigation of small bowel tumors, and surveillance of hereditary polyposis syndromes. Since the introduction of small bowel VCE in 2000, more than 1600 articles have been published describing the evolution of this technology. The main adverse outcome is capsule retention, which can potentially be avoided by careful patient selection or by using a patency capsule. Despite the numerous advances in the past 15 years, limitations such as incomplete VCE studies, missed lesions, and time-consuming reporting remain. The inability to control capsule movement for the application of targeted therapy or the acquisition of tissue for histologic analysis remains among the greatest challenges in the further development of capsule technology. This article outlines the recent technological and clinical advances in VCE and the future directions of research in this field. PMID:27482183

  13. Advances in Capsule Endoscopy.

    PubMed

    Scott, Ryan; Enns, Robert

    2015-09-01

    Wireless video capsule endoscopy (VCE) is a minimally invasive technology that has revolutionized the approach to small intestinal disease investigation and management. Designed primarily to provide diagnostic imaging of the small intestine, VCE is used predominantly for obscure gastrointestinal bleeding and suspected Crohn's disease; however, numerous other indications have been established, including the assessment of celiac disease, investigation of small bowel tumors, and surveillance of hereditary polyposis syndromes. Since the introduction of small bowel VCE in 2000, more than 1600 articles have been published describing the evolution of this technology. The main adverse outcome is capsule retention, which can potentially be avoided by careful patient selection or by using a patency capsule. Despite the numerous advances in the past 15 years, limitations such as incomplete VCE studies, missed lesions, and time-consuming reporting remain. The inability to control capsule movement for the application of targeted therapy or the acquisition of tissue for histologic analysis remains among the greatest challenges in the further development of capsule technology. This article outlines the recent technological and clinical advances in VCE and the future directions of research in this field. PMID:27482183

  14. Advancing empirical resilience research.

    PubMed

    Kalisch, Raffael; Müller, Marianne B; Tüscher, Oliver

    2015-01-01

    We are delighted by the broad, intense, and fruitful discussion in reaction to our target article. A major point we take from the many comments is a prevailing feeling in the research community that we need significantly and urgently to advance resilience research, both by sharpening concepts and theories and by conducting empirical studies at a much larger scale and with a much more extended and sophisticated methodological arsenal than is the case currently. This advancement can be achieved only in a concerted international collaborative effort. In our response, we try to argue that an explicitly atheoretical, purely observational definition of resilience and a transdiagnostic, quantitative study framework can provide a suitable basis for empirically testing different competing resilience theories (sects. R1, R2, R6, R7). We are confident that it should be possible to unite resilience researchers from different schools, including from sociology and social psychology, behind such a pragmatic and theoretically neutral research strategy. In sections R3 to R5, we further specify and explain the positive appraisal style theory of resilience (PASTOR). We defend PASTOR as a comparatively parsimonious and translational theory that makes sufficiently concrete predictions to be evaluated empirically. PMID:26815844

  15. NASA advanced propeller research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1988-01-01

    Acoustic and aerodynamic research at NASA Lewis Research Center on advanced propellers is reviewed including analytical and experimental results on both single and counterrotation. Computational tools used to calculate the detailed flow and acoustic fields are described along with wind tunnel tests to obtain data for code verification. Results from two kinds of experiments are reviewed: (1) performance and near field noise at cruise conditions as measured in the NASA Lewis 8- by 6-foot Wind Tunnel; and (2) far field noise and performance for takeoff/approach conditions as measured in the NASA Lewis 9- by 15-foot Anechoic Wind Tunnel. Detailed measurements of steady blade surface pressures are described along with vortex flow phenomena at off-design conditions. Near field noise at cruise is shown to level out or decrease as tip relative Mach number is increased beyond 1.15. Counterrotation interaction noise is shown to be a dominant source at takeoff but a secondary source at cruise. Effects of unequal rotor diameters and rotor-to-rotor spacing on interaction noise are also illustrated. Comparisons of wind tunnel acoustic measurements to flight results are made. Finally, some future directions in advanced propeller research such as swirl recovery vanes, higher sweep, forward sweep, and ducted propellers are discussed.

  16. NASA Advanced Propeller Research

    NASA Technical Reports Server (NTRS)

    Groeneweg, John F.; Bober, Lawrence J.

    1988-01-01

    Acoustic and aerodynamic research at NASA Lewis Research Center on advanced propellers is reviewed including analytical and experimental results on both single and counterrotation. Computational tools used to calculate the detailed flow and acoustic i e l d s a r e described along with wind tunnel tests to obtain data for code verification . Results from two kinds of experiments are reviewed: ( 1 ) performance and near field noise at cruise conditions as measured in the NASA Lewis 8-by 6-Foot Wind Tunnel and ( 2 ) farfield noise and performance for takeoff/approach conditions as measured in the NASA Lewis 9-by 15-Font Anechoic Wind Tunnel. Detailed measurements of steady blade surface pressures are described along with vortex flow phenomena at off design conditions . Near field noise at cruise is shown to level out or decrease as tip relative Mach number is increased beyond 1.15. Counterrotation interaction noise is shown to be a dominant source at take off but a secondary source at cruise. Effects of unequal rotor diameters and rotor-to-rotor spacing on interaction noise a real so illustrated. Comparisons of wind tunnel acoustic measurements to flight results are made. Finally, some future directions in advanced propeller research such as swirl recovery vanes, higher sweep, forward sweep, and ducted propellers are discussed.

  17. Pulmonary infantile hemangioma presenting as a mass in a premature male infant: a case report focusing on pathological features.

    PubMed

    Siaghani, Parwiz J; Chavez, Claire; Anselmo, Dean M; Shane, Lisa

    2015-01-01

    Infantile hemangiomas are the most common benign neoplasm of infancy, with most occurring in the head and neck region. Predisposing factors include prematurity, low birth weight, multiple gestations, advanced maternal age, and chorionic villous sampling. In addition, white women, particularly those with a family history, are also at a higher risk. However, pulmonary infantile hemangiomas are exceedingly rare, with only a few case reports in the literature. Infantile hemangiomas should be considered in the differential diagnosis of a pulmonary mass in the early pediatric population. We present a case of pulmonary infantile hemangioma in a premature male infant successfully managed by surgical excision, with an emphasis on the pathogenesis and histologic features.

  18. Acute arsenic poisoning: clinical and histopathological features.

    PubMed

    Bartolomé, B; Córdoba, S; Nieto, S; Fernández-Herrera, J; García-Díez, A

    1999-12-01

    We report a woman with acute arsenic poisoning, who developed an erythroderma with vesicles and pustules after the ingestion of 8-16 g of sodium arsenite. Simultaneously, she presented a herpes simplex virus infection. Skin biopsies showed unique features which included multiple small pigment granules inside and outside the histiocytes. In our opinion, these findings are consistent with acute arsenic poisoning, and constitute the first histological description of this entity in skin.

  19. Significance analysis of qualitative mammographic features, using linear classifiers, neural networks and support vector machines.

    PubMed

    Mavroforakis, Michael; Georgiou, Harris; Dimitropoulos, Nikos; Cavouras, Dionisis; Theodoridis, Sergios

    2005-04-01

    Advances in modern technologies and computers have enabled digital image processing to become a vital tool in conventional clinical practice, including mammography. However, the core problem of the clinical evaluation of mammographic tumors remains a highly demanding cognitive task. In order for these automated diagnostic systems to perform in levels of sensitivity and specificity similar to that of human experts, it is essential that a robust framework on problem-specific design parameters is formulated. This study is focused on identifying a robust set of clinical features that can be used as the base for designing the input of any computer-aided diagnosis system for automatic mammographic tumor evaluation. A thorough list of clinical features was constructed and the diagnostic value of each feature was verified against current clinical practices by an expert physician. These features were directly or indirectly related to the overall morphological properties of the mammographic tumor or the texture of the fine-scale tissue structures as they appear in the digitized image, while others contained external clinical data of outmost importance, like the patient's age. The entire feature set was used as an annotation list for describing the clinical properties of mammographic tumor cases in a quantitative way, such that subsequent objective analyses were possible. For the purposes of this study, a mammographic image database was created, with complete clinical evaluation descriptions and positive histological verification for each case. All tumors contained in the database were characterized according to the identified clinical features' set and the resulting dataset was used as input for discrimination and diagnostic value analysis for each one of these features. Specifically, several standard methodologies of statistical significance analysis were employed to create feature rankings according to their discriminating power. Moreover, three different classification

  20. Benefits of advanced propulsion technology for the advanced supersonic transport

    NASA Technical Reports Server (NTRS)

    Hines, R. W.; Sabatella, J. A.

    1973-01-01

    Future supersonic transports will have to provide improvement in the areas of economics, range, and emissions relative to the present generation of supersonic transports, as well as meeting or improving upon FAR 36 noise goals. This paper covers the promising propulsion systems including variable-cycle engine concepts for long-range supersonic commercial transport application. The benefits of applying advanced propulsion technology to solve the economic and environmental problems are reviewed. The advanced propulsion technologies covered are in the areas of structures, materials, cooling techniques, aerodynamics, variable engine geometry, jet noise suppressors, acoustic treatment, and low-emission burners. The results of applying the advanced propulsion technology are presented in terms of improvement in overall system takeoff gross weight and return on investment.

  1. SAPHIRE 8 New Features and Capabilities

    SciTech Connect

    Curtis Smith

    2008-08-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) software performs probabilistic risk assessment (PRA) calculations. SAPHIRE is used in support of NRC’s risk-informed programs such as the Accident Sequence Precursor (ASP) program, Management Directive 8.3, “NRC Incident Investigation Program,” or the Significance Determination Process (SDP). It is also used to develop and run the Standardized Plant Analysis Risk (SPAR) models. SAPHIRE Version 8 is a new version of the software with an improved interface and capabilities to support risk-informed programs. SAPHIRE Version 8 is designed to easily handle larger and more complex models. Applications of previous SAPHIRE versions indicated the need to build and solve models with a large number of sequences. Risk assessments that include endstate evaluations for core damage frequency and large, early release frequency evaluations have greatly increased the number of sequences required. In addition, the complexity of the models has increased since risk assessments evaluate both potential internal and external events, as well as different plant operational states. Special features of SAPHIRE 8 help create and run integrated models which may be composed of different model types. SAPHIRE 8 includes features and capabilities that are new or improved over the current Version 7 to address the new requirements for risk-informed programs and SPAR models. These include: • Improved User Interfaces • Model development • Methods • General Support Features

  2. Feature enhancement and phonological acquisition.

    PubMed

    Yavas, M

    1997-01-01

    Distinctive features have been part of clinical work in phonological assessment and therapy. In almost all studies the set of features used was the Chomsky and Halle system. Stevens and Keyser (1989) offer a new look at distinctive features from the dimension of perceptual saliency, and account for the markedness relationship between segments. This paper explores to what extent it is possible to account for the substitution patterns in child phonologies based on the concepts of feature hierarchy, enhancement, and perceptual saliency as proposed by Stevens and Keyser. Concentrating on the consonantal substitutions in normal and disordered child speech, an attempt is made to distinguish between normal and unusual/idiosyncratic processes. Implications for assessment are discussed. PMID:21271756

  3. Reliability and Validity of Advanced Phonics Measures

    ERIC Educational Resources Information Center

    Doty, Sara J.; Hixson, Michael D.; Decker, Dawn M.; Reynolds, Jennifer L.; Drevon, Daniel D.

    2015-01-01

    Two studies explored the technical adequacy of various measures of advanced phonics skills. In Study 1, the advanced phonics measures consisted of pseudowords, real words, or a combination of both. Participants included 39 students in the third grade. Test-retest correlations for all measures were above 0.8 and interrater reliability was high.…

  4. Video Fact Sheets: Everyday Advanced Materials

    SciTech Connect

    2015-10-06

    What are Advanced Materials? Ames Laboratory is behind some of the best advanced materials out there. Some of those include: Lead-Free Solder, Photonic Band-Gap Crystals, Terfenol-D, Aluminum-Calcium Power Cable and Nano Particles. Some of these are in products we use every day.

  5. Video Fact Sheets: Everyday Advanced Materials

    ScienceCinema

    None

    2016-07-12

    What are Advanced Materials? Ames Laboratory is behind some of the best advanced materials out there. Some of those include: Lead-Free Solder, Photonic Band-Gap Crystals, Terfenol-D, Aluminum-Calcium Power Cable and Nano Particles. Some of these are in products we use every day.

  6. Spectroradiometric considerations for advanced land observing systems

    NASA Technical Reports Server (NTRS)

    Slater, P. N.

    1986-01-01

    Research aimed at improving the inflight absolute radiometric calibration of advanced land observing systems was initiated. Emphasis was on the satellite sensor calibration program at White Sands. Topics addressed include: absolute radiometric calibration of advanced remote sensing; atmospheric effects on reflected radiation; inflight radiometric calibration; field radiometric methods for reflectance and atmospheric measurement; and calibration of field relectance radiometers.

  7. 47 CFR 1.9005 - Included services.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... below 470 MHz, including those licensed pursuant to 47 CFR 90.187(b)(2)(v)); (z) The 218-219 MHz band... Spectrum Leasing Scope and Authority § 1.9005 Included services. Link to an amendment published at 79 FR 48533, August 15, 2014. The spectrum leasing policies and rules of this subpart apply to the...

  8. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  9. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  10. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  11. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Judicial Administration DEPARTMENT OF JUSTICE CRIMINAL JUSTICE INFORMATION SYSTEMS Federal Systems and Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record information maintained in the III System and the FIRS shall include serious and/or significant adult...

  12. 28 CFR 20.32 - Includable offenses.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Exchange of Criminal History Record Information § 20.32 Includable offenses. (a) Criminal history record... by a § 20.32(a) offense. These exclusions may not be applicable to criminal history records maintained in state criminal history record repositories, including those states participating in the NFF....

  13. Persistent topological features of dynamical systems.

    PubMed

    Maletić, Slobodan; Zhao, Yi; Rajković, Milan

    2016-05-01

    Inspired by an early work of Muldoon et al., Physica D 65, 1-16 (1993), we present a general method for constructing simplicial complex from observed time series of dynamical systems based on the delay coordinate reconstruction procedure. The obtained simplicial complex preserves all pertinent topological features of the reconstructed phase space, and it may be analyzed from topological, combinatorial, and algebraic aspects. In focus of this study is the computation of homology of the invariant set of some well known dynamical systems that display chaotic behavior. Persistent homology of simplicial complex and its relationship with the embedding dimensions are examined by studying the lifetime of topological features and topological noise. The consistency of topological properties for different dynamic regimes and embedding dimensions is examined. The obtained results shed new light on the topological properties of the reconstructed phase space and open up new possibilities for application of advanced topological methods. The method presented here may be used as a generic method for constructing simplicial complex from a scalar time series that has a number of advantages compared to the mapping of the same time series to a complex network.

  14. Spatial Relation Predicates in Topographic Feature Semantics

    USGS Publications Warehouse

    Varanka, Dalia E.; Caro, Holly K.

    2013-01-01

    Topographic data are designed and widely used for base maps of diverse applications, yet the power of these information sources largely relies on the interpretive skills of map readers and relational database expert users once the data are in map or geographic information system (GIS) form. Advances in geospatial semantic technology offer data model alternatives for explicating concepts and articulating complex data queries and statements. To understand and enrich the vocabulary of topographic feature properties for semantic technology, English language spatial relation predicates were analyzed in three standard topographic feature glossaries. The analytical approach drew from disciplinary concepts in geography, linguistics, and information science. Five major classes of spatial relation predicates were identified from the analysis; representations for most of these are not widely available. The classes are: part-whole (which are commonly modeled throughout semantic and linked-data networks), geometric, processes, human intention, and spatial prepositions. These are commonly found in the ‘real world’ and support the environmental science basis for digital topographical mapping. The spatial relation concepts are based on sets of relation terms presented in this chapter, though these lists are not prescriptive or exhaustive. The results of this study make explicit the concepts forming a broad set of spatial relation expressions, which in turn form the basis for expanding the range of possible queries for topographical data analysis and mapping.

  15. Persistent topological features of dynamical systems

    NASA Astrophysics Data System (ADS)

    Maletić, Slobodan; Zhao, Yi; Rajković, Milan

    2016-05-01

    Inspired by an early work of Muldoon et al., Physica D 65, 1-16 (1993), we present a general method for constructing simplicial complex from observed time series of dynamical systems based on the delay coordinate reconstruction procedure. The obtained simplicial complex preserves all pertinent topological features of the reconstructed phase space, and it may be analyzed from topological, combinatorial, and algebraic aspects. In focus of this study is the computation of homology of the invariant set of some well known dynamical systems that display chaotic behavior. Persistent homology of simplicial complex and its relationship with the embedding dimensions are examined by studying the lifetime of topological features and topological noise. The consistency of topological properties for different dynamic regimes and embedding dimensions is examined. The obtained results shed new light on the topological properties of the reconstructed phase space and open up new possibilities for application of advanced topological methods. The method presented here may be used as a generic method for constructing simplicial complex from a scalar time series that has a number of advantages compared to the mapping of the same time series to a complex network.

  16. Testosterone in men with advanced liver disease: abnormalities and implications.

    PubMed

    Sinclair, Marie; Grossmann, Mathis; Gow, Paul J; Angus, Peter W

    2015-02-01

    Serum testosterone is reduced in up to 90% of men with cirrhosis, with levels falling as liver disease advances. Testosterone is an important anabolic hormone, with effects on muscle, bone, and hematopoiesis. Many of the features of advanced liver disease are similar to those seen in hypogonadal men, including sarcopenia, osteoporosis, gynecomastia, and low libido. However, the relative contribution of testosterone deficiency to the symptomatology of advanced liver disease has not been well established. More recently, it has been demonstrated that low testosterone in men with cirrhosis is associated with increased mortality, independent of the classically recognized prognostic factors, such as the Model for End-Stage Liver Disease score. Only several small clinical trials have examined the role of testosterone therapy in men with cirrhosis, none of which have resolved the issue of whether or not testosterone is beneficial. However, in men with organic hypogonadism due to structural hypothalamic-pituitary-testicular axis disease, testosterone therapy has been shown to improve muscle mass and bone mineral density, increase hemoglobin, and reduce insulin resistance. Despite initial concerns linking testosterone with hepatocellular carcinoma, more recent data suggest that this risk has been overstated. There is, therefore, now a strong rationale to assess the efficacy and safety of testosterone therapy in cirrhosis in well-designed randomized controlled trials. PMID:25087838

  17. Study of advanced rotary combustion engines for commuter aircraft

    NASA Technical Reports Server (NTRS)

    Berkowitz, M.; Jones, C.; Myers, D.

    1983-01-01

    Performance, weight, size, and maintenance data for advanced rotary aircraft engines suitable for comparative commuter aircraft system evaluation studies of alternate engine candidates are provided. These are turbocharged, turbocompounded, direct injected, stratified charge rotary engines. Hypothetical engines were defined (an RC4-74 at 895 kW and an RC6-87 at 1490 kW) based on the technologies and design approaches used in the highly advanced engine of a study of advanced general aviation rotary engines. The data covers the size range of shaft power from 597 kW (800 hp) to 1865 kW (2500 hp) and is in the form of drawings, tables, curves and written text. These include data on internal geometry and configuration, installation information, turbocharging and turbocompounding arrangements, design features and technologies, engine cooling, fuels, scaling for weight size BSFC and heat rejection for varying horsepower, engine operating and performance data, and TBO and maintenance requirements. The basic combustion system was developed and demonstrated; however the projected power densities and performance efficiencies require increases in engine internal pressures, thermal loading, and rotative speed.

  18. Recent advances and future prospects for Monte Carlo

    SciTech Connect

    Brown, Forrest B

    2010-01-01

    The history of Monte Carlo methods is closely linked to that of computers: The first known Monte Carlo program was written in 1947 for the ENIAC; a pre-release of the first Fortran compiler was used for Monte Carlo In 1957; Monte Carlo codes were adapted to vector computers in the 1980s, clusters and parallel computers in the 1990s, and teraflop systems in the 2000s. Recent advances include hierarchical parallelism, combining threaded calculations on multicore processors with message-passing among different nodes. With the advances In computmg, Monte Carlo codes have evolved with new capabilities and new ways of use. Production codes such as MCNP, MVP, MONK, TRIPOLI and SCALE are now 20-30 years old (or more) and are very rich in advanced featUres. The former 'method of last resort' has now become the first choice for many applications. Calculations are now routinely performed on office computers, not just on supercomputers. Current research and development efforts are investigating the use of Monte Carlo methods on FPGAs. GPUs, and many-core processors. Other far-reaching research is exploring ways to adapt Monte Carlo methods to future exaflop systems that may have 1M or more concurrent computational processes.

  19. Computerized structural mechanics for 1990's: Advanced aircraft needs

    NASA Technical Reports Server (NTRS)

    Viswanathan, A. V.; Backman, B. F.

    1989-01-01

    The needs for computerized structural mechanics (CSM) as seen from the standpoint of the aircraft industry are discussed. These needs are projected into the 1990's with special focus on the new advanced materials. Preliminary design/analysis, research, and detail design/analysis are identified as major areas. The role of local/global analyses in these different areas is discussed. The lessons learned in the past are used as a basis for the design of a CSM framework that could modify and consolidate existing technology and include future developments in a rational and useful way. A philosophy is stated, and a set of analyses needs driven by the emerging advanced composites is enumerated. The roles of NASA, the universities, and the industry are identified. Finally, a set of rational research targets is recommended based on both the new types of computers and the increased complexity the industry faces. Computerized structural mechanics should be more than new methods in structural mechanics and numerical analyses. It should be a set of engineering applications software products that combines innovations in structural mechanics, numerical analysis, data processing, search and display features, and recent hardware advances and is organized in a framework that directly supports the design process.

  20. Advanced Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Demonstration

    SciTech Connect

    Curtis Smith; Steven Prescott; Tony Koonce

    2014-04-01

    A key area of the Advanced Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) strategy is the development of methodologies and tools that will be used to predict the safety, security, safeguards, performance, and deployment viability of SMRs. The goal of the SMR PRA activity will be to develop quantitative methods and tools and the associated analysis framework for assessing a variety of risks. Development and implementation of SMR-focused safety assessment methods may require new analytic methods or adaptation of traditional methods to the advanced design and operational features of SMRs. We will need to move beyond the current limitations such as static, logic-based models in order to provide more integrated, scenario-based models based upon predictive modeling which are tied to causal factors. The development of SMR-specific safety models for margin determination will provide a safety case that describes potential accidents, design options (including postulated controls), and supports licensing activities by providing a technical basis for the safety envelope. This report documents the progress that was made to implement the PRA framework, specifically by way of demonstration of an advanced 3D approach to representing, quantifying and understanding flooding risks to a nuclear power plant.

  1. Advances in orthodontics.

    PubMed

    Cunningham, Susan J; Jones, Steven P; Hodges, Samantha J; Horrocks, Elisabeth N; Hunt, Nigel P; Moseley, Howard C; Noar, Joseph H

    2002-01-01

    There has been tremendous progress in orthodontics since Edward Angle first popularised the fixed orthodontic appliance at the turn of the century. Recent years have seen an increased demand for orthodontic treatment from both adolescents and adults and, in addition, patient and clinician expectations of treatment outcomes continue to rise. A desire for more aesthetic materials has resulted in both smaller and 'tooth-coloured' appliances. Improvements in technology, often outside orthodontics, have also led to the development of new materials. The best example of this was the development of nickel titanium alloy by the NASA space programme, which was subsequently adapted for use in nickel titanium archwires. Other technological advances adopted for use in orthodontics include magnets, computerised imaging systems and distraction osteogenesis. This review paper looks at some of the innovations in the fields of materials as well as in techniques and appliance systems.

  2. ADVANCED CUTTINGS TRANSPORT STUDY

    SciTech Connect

    Ergun Kuru; Stefan Miska; Nicholas Takach; Kaveh Ashenayi; Gerald Kane; Len Volk; Mark Pickell; Evren Ozbayoglu; Barkim Demirdal; Paco Vieira; Affonso Lourenco

    1999-10-15

    This report includes a review of the progress made in ACTF Flow Loop development and research during 90 days pre-award period (May 15-July 14, 1999) and the following three months after the project approval date (July15-October 15, 1999) The report presents information on the following specific subjects; (a) Progress in Advanced Cuttings Transport Facility design and development, (b) Progress report on the research project ''Study of Flow of Synthetic Drilling Fluids Under Elevated Pressure and Temperature Conditions'', (c) Progress report on the research project ''Study of Cuttings Transport with Foam Under LPAT Conditions (Joint Project with TUDRP)'', (d) Progress report on the research project ''Study of Cuttings Transport with Aerated Muds Under LPAT Conditions (Joint Project with TUDRP)'', (e) Progress report on the research project ''Study of Foam Flow Behavior Under EPET Conditions'', (f) Progress report on the instrumentation tasks (Tasks 11 and 12) (g) Activities towards technology transfer and developing contacts with oil and service company members.

  3. Advanced Motor Drives Studies

    NASA Technical Reports Server (NTRS)

    Ehsani, M.; Tchamdjou, A.

    1997-01-01

    This report presents an evaluation of advanced motor drive systems as a replacement for the hydrazine fueled APU units. The replacement technology must meet several requirements which are particular to the space applications and the Orbiter in general. Some of these requirements are high efficiency, small size, high power density. In the first part of the study several motors are compared, based on their characteristics and in light of the Orbiter requirements. The best candidate, the brushless DC is chosen because of its particularly good performance with regards to efficiency. Several power electronics drive technologies including the conventional three-phase hard switched and several soft-switched inverters are then presented. In the last part of the study, a soft-switched inverter is analyzed and compared to its conventional hard-switched counterpart. Optimal efficiency is a basic requirement for space applications and the soft-switched technology represents an unavoidable trend for the future.

  4. Advanced servo manipulator

    DOEpatents

    Holt, William E.; Kuban, Daniel P.; Martin, H. Lee

    1988-01-01

    An advanced servo manipulator has modular parts. Modular motor members drive individual input gears to control shoulder roll, shoulder pitch, elbow pitch, wrist yaw, wrist pitch, wrist roll, and tong spacing. The modules include a support member, a shoulder module for controlling shoulder roll, and a sleeve module attached to the shoulder module in fixed relation thereto. The shoulder roll sleeve module has an inner cylindrical member rotatable relative to the outer cylindrical member, and upon which a gear pod assembly is mounted. A plurality of shafts are driven by the gears, which are in turn driven by individual motor modules to transmit rotary power to control elbow pitch as well as to provide four different rotary shafts across the bendable elbow joint to supply rotary motive power to a wrist member and tong member.

  5. Advances in treating psoriasis

    PubMed Central

    Belge, Katharina; Brück, Jürgen

    2014-01-01

    Psoriasis is a T helper (Th)17/Th1-mediated autoimmune disease affecting the skin and joints. So far, distinct traditional oral compounds and modern biologics have been approved in most countries for the treatment of patients with moderate to severe psoriasis or psoriatic arthritis. Yet, the anti-psoriatic therapeutic spectrum is to be extended by a number of novel targeted therapies including biologics and modern oral compounds. The next set of anti-psoriatic biologics targets mainly Th17-associated cytokines such as IL-17 or IL-23. In contrast, modern oral anti-psoriatics, such as dimethyl fumarate (DMF), apremilast or Janus kinase (JAK) inhibitors interfere with intracellular proteins and affect signaling pathways. Here we summarize the current systemic therapies for psoriasis and their immunological mechanism. The recent advances in psoriasis therapy will help treat our patients efficiently and complete our understanding of disease pathogenesis. PMID:24592316

  6. Advanced servo manipulator

    DOEpatents

    Holt, W.E.; Kuban, D.P.; Martin, H.L.

    1988-10-25

    An advanced servo manipulator has modular parts. Modular motor members drive individual input gears to control shoulder roll, shoulder pitch, elbow pitch, wrist yaw, wrist pitch, wrist roll, and tong spacing. The modules include a support member, a shoulder module for controlling shoulder roll, and a sleeve module attached to the shoulder module in fixed relation thereto. The shoulder roll sleeve module has an inner cylindrical member rotatable relative to the outer cylindrical member, and upon which a gear pod assembly is mounted. A plurality of shafts are driven by the gears, which are in turn driven by individual motor modules to transmit rotary power to control elbow pitch as well as to provide four different rotary shafts across the bendable elbow joint to supply rotary motive power to a wrist member and tong member. 41 figs.

  7. USMC UGS technology advancements

    NASA Astrophysics Data System (ADS)

    Hartup, David C.; Barr, Michael E.; Hirz, Philip M.; Kipp, Jason; Fishburn, Thomas A.; Waller, Ezra S.; Marks, Brian A.

    2008-04-01

    Technology advancements for the USMC UGS system are described. Integration of the ARL Blue Radio/CSR into the System Controller and Radio Repeater permit the TRSS system to operate seamlessly within the Family of UGS concept. In addition to the Blue Radio/CSR, the TRSS system provides VHF and SATCOM radio links. The TRSS system is compatible with a wide range of imagers, including those with both analog and digital interfaces. The TRSS System Controller permits simultaneous monitoring of 2 camera inputs. To complement enhanced compatibility and improved processing, the mechanical housing of the TRSS System Controller has been updated. The SDR-II, a system monitoring device, also incorporates four Blue Radio/CSRs along with other communication capabilities, making it an ideal choice for a monitoring station within the Family of UGS. Field testing of L-3 Nova's UGS system at YPG has shown flawless performance, capturing all 126 targets.

  8. Advanced drilling systems study.

    SciTech Connect

    Pierce, Kenneth G.; Livesay, Billy Joe; Finger, John Travis

    1996-05-01

    This report documents the results of a study of advanced drilling concepts conducted jointly for the Natural Gas Technology Branch and the Geothermal Division of the U.S. Department of Energy. A number of alternative rock cutting concepts and drilling systems are examined. The systems cover the range from current technology, through ongoing efforts in drilling research, to highly speculative concepts. Cutting mechanisms that induce stress mechanically, hydraulically, and thermally are included. All functions necessary to drill and case a well are considered. Capital and operating costs are estimated and performance requirements, based on comparisons of the costs for alternative systems to conventional drilling technology, are developed. A number of problems common to several alternatives and to current technology are identified and discussed.

  9. Advances in Alcoholism Treatment

    PubMed Central

    Huebner, Robert B.; Kantor, Lori Wolfgang

    2011-01-01

    Researchers are working on numerous and varied approaches to improving the accessibility, quality, effectiveness, and cost-effectiveness of treatment for alcohol use disorders (AUDs). This overview article summarizes the approaches reviewed in this issue, including potential future developments for alcoholism treatment, such as medications development, behavioral therapy, advances in technology that are being used to improve treatment, integrated care of patients with AUDs and co-occurring disorders, the role of 12-step programs in the broader realm of treatment, treating patients with recurring and chronic alcohol dependence, strategies to close the gap between treatment need and treatment utilization, and how changes in the health care system may affect the delivery of treatment. This research will not only reveal new medications and behavioral therapies but also will contribute to new ways of approaching current treatment problems. PMID:23580014

  10. Manifestations of advanced civilizations

    NASA Astrophysics Data System (ADS)

    Bracewell, R. N.

    A list of possible modes of detecting advanced civilizations elsewhere in the universe is provided, including EM Alfven, and gravity waves, matter transfer, and exotica such as tachyons, black hole tunneling, and telepathy. Further study is indicated for low frequency radio wave propagation, which may travel along magnetic fields to reach the earth while laser beams are not favored because of the power needed for transmitting quanta instead of waves. IR, X ray, and UV astronomy are noted to be suitable for detecting signals in those ranges, while Alfven wave communication will be best observed by probes outside the orbit of Jupiter, where local anomalies have less effect. Particle propagation communication is viewed as unlikely, except as a trace of an extinct civilization, but panspermia, which involves interstellar spreading of seeds and/or spores, receives serious attention, as does laser probe or pellet propulsion.

  11. Advanced Ceramics Property Measurements

    NASA Technical Reports Server (NTRS)

    Salem, Jonathan; Helfinstine, John; Quinn, George; Gonczy, Stephen

    2013-01-01

    Mechanical and physical properties of ceramic bodies can be difficult to measure correctly unless the proper techniques are used. The Advanced Ceramics Committee of ASTM, C-28, has developed dozens of consensus test standards and practices to measure various properties of a ceramic monolith, composite, or coating. The standards give the "what, how, how not, and why" for measurement of many mechanical, physical, thermal, and performance properties. Using these standards will provide accurate, reliable, and complete data for rigorous comparisons with other test results from your test lab, or another. The C-28 Committee has involved academics, producers, and users of ceramics to write and continually update more than 45 standards since the committee's inception in 1986. Included in this poster is a pictogram of the C-28 standards and information on how to obtain individual copies with full details or the complete collection of standards in one volume.

  12. Advances in Antibody Design.

    PubMed

    Tiller, Kathryn E; Tessier, Peter M

    2015-01-01

    The use of monoclonal antibodies as therapeutics requires optimizing several of their key attributes. These include binding affinity and specificity, folding stability, solubility, pharmacokinetics, effector functions, and compatibility with the attachment of additional antibody domains (bispecific antibodies) and cytotoxic drugs (antibody-drug conjugates). Addressing these and other challenges requires the use of systematic design methods that complement powerful immunization and in vitro screening methods. We review advances in designing the binding loops, scaffolds, domain interfaces, constant regions, post-translational and chemical modifications, and bispecific architectures of antibodies and fragments thereof to improve their bioactivity. We also highlight unmet challenges in antibody design that must be overcome to generate potent antibody therapeutics. PMID:26274600

  13. Current advances and future perspectives in extrusion-based bioprinting.

    PubMed

    Ozbolat, Ibrahim T; Hospodiuk, Monika

    2016-01-01

    Extrusion-based bioprinting (EBB) is a rapidly growing technology that has made substantial progress during the last decade. It has great versatility in printing various biologics, including cells, tissues, tissue constructs, organ modules and microfluidic devices, in applications from basic research and pharmaceutics to clinics. Despite the great benefits and flexibility in printing a wide range of bioinks, including tissue spheroids, tissue strands, cell pellets, decellularized matrix components, micro-carriers and cell-laden hydrogels, the technology currently faces several limitations and challenges. These include impediments to organ fabrication, the limited resolution of printed features, the need for advanced bioprinting solutions to transition the technology bench to bedside, the necessity of new bioink development for rapid, safe and sustainable delivery of cells in a biomimetically organized microenvironment, and regulatory concerns to transform the technology into a product. This paper, presenting a first-time comprehensive review of EBB, discusses the current advancements in EBB technology and highlights future directions to transform the technology to generate viable end products for tissue engineering and regenerative medicine. PMID:26561931

  14. Advanced Fuels Campaign FY 2015 Accomplishments Report

    SciTech Connect

    Braase, Lori Ann; Carmack, William Jonathan

    2015-10-29

    The mission of the Advanced Fuels Campaign (AFC) is to perform research, development, and demonstration (RD&D) activities for advanced fuel forms (including cladding) to enhance the performance and safety of the nation’s current and future reactors; enhance proliferation resistance of nuclear fuel; effectively utilize nuclear energy resources; and address the longer-term waste management challenges. This report is a compilation of technical accomplishment summaries for FY-15. Emphasis is on advanced accident-tolerant LWR fuel systems, advanced transmutation fuels technologies, and capability development.

  15. Selective Audiovisual Semantic Integration Enabled by Feature-Selective Attention.

    PubMed

    Li, Yuanqing; Long, Jinyi; Huang, Biao; Yu, Tianyou; Wu, Wei; Li, Peijun; Fang, Fang; Sun, Pei

    2016-01-13

    An audiovisual object may contain multiple semantic features, such as the gender and emotional features of the speaker. Feature-selective attention and audiovisual semantic integration are two brain functions involved in the recognition of audiovisual objects. Humans often selectively attend to one or several features while ignoring the other features of an audiovisual object. Meanwhile, the human brain integrates semantic information from the visual and auditory modalities. However, how these two brain functions correlate with each other remains to be elucidated. In this functional magnetic resonance imaging (fMRI) study, we explored the neural mechanism by which feature-selective attention modulates audiovisual semantic integration. During the fMRI experiment, the subjects were presented with visual-only, auditory-only, or audiovisual dynamical facial stimuli and performed several feature-selective attention tasks. Our results revealed that a distribution of areas, including heteromodal areas and brain areas encoding attended features, may be involved in audiovisual semantic integration. Through feature-selective attention, the human brain may selectively integrate audiovisual semantic information from attended features by enhancing functional connectivity and thus regulating information flows from heteromodal areas to brain areas encoding the attended features.

  16. Advanced Electrophysiologic Mapping Systems

    PubMed Central

    2006-01-01

    has not been found to be effective for the treatment of complex arrhythmias such as chronic atrial fibrillation or ventricular tachycardia. Advanced nonfluoroscopic mapping systems have been developed for guiding the ablation of these complex arrhythmias. The Technology Four nonfluoroscopic advanced mapping systems have been licensed by Health Canada: CARTO EP mapping System (manufactured by Biosense Webster, CA) uses weak magnetic fields and a special mapping/ablation catheter with a magnetic sensor to locate the catheter and reconstruct a 3-dimensional geometry of the heart superimposed with colour-coded electric potential maps to guide ablation. EnSite System (manufactured by Endocardial Solutions Inc., MN) includes a multi-electrode non-contact catheter that conducts simultaneous mapping. A processing unit uses the electrical data to computes more than 3,000 isopotential electrograms that are displayed on a reconstructed 3-dimensional geometry of the heart chamber. The navigational system, EnSite NavX, can be used separately with most mapping catheters. The LocaLisa Intracardiac System (manufactured by Medtronics Inc, MN) is a navigational system that uses an electrical field to locate the mapping catheter. It reconstructs the location of the electrodes on the mapping catheter in 3-dimensional virtual space, thereby enabling an ablation catheter to be directed to the electrode that identifies abnormal electric potential. Polar Constellation Advanced Mapping Catheter System (manufactured by Boston Scientific, MA) is a multielectrode basket catheter with 64 electrodes on 8 splines. Once deployed, each electrode is automatically traced. The information enables a 3-dimensional model of the basket catheter to be computed. Colour-coded activation maps are reconstructed online and displayed on a monitor. By using this catheter, a precise electrical map of the atrium can be obtained in several heartbeats. Review Strategy A systematic search of Cochrane, MEDLINE and EMBASE

  17. Translational research on advanced therapies.

    PubMed

    Belardelli, Filippo; Rizza, Paola; Moretti, Franca; Carella, Cintia; Galli, Maria Cristina; Migliaccio, Giovanni

    2011-01-01

    Fostering translational research of advanced therapies has become a major priority of both scientific community and national governments. Advanced therapy medicinal products (ATMP) are a new medicinal product category comprising gene therapy and cell-based medicinal products as well as tissue engineered medicinal products. ATMP development opens novel avenues for therapeutic approaches in numerous diseases, including cancer and neurodegenerative and cardiovascular diseases. However, there are important bottlenecks for their development due to the complexity of the regulatory framework, the high costs and the needs for good manufacturing practice (GMP) facilities and new end-points for clinical experimentation. Thus, a strategic cooperation between different stakeholders (academia, industry and experts in regulatory issues) is strongly needed. Recently, a great importance has been given to research infrastructures dedicated to foster translational medicine of advanced therapies. Some ongoing European initiatives in this field are presented and their potential impact is discussed.

  18. Process for producing advanced ceramics

    DOEpatents

    Kwong, Kyei-Sing

    1996-01-01

    A process for the synthesis of homogeneous advanced ceramics such as SiC+AlN, SiAlON, SiC+Al.sub.2 O.sub.3, and Si.sub.3 N.sub.4 +AlN from natural clays such as kaolin, halloysite and montmorillonite by an intercalation and heat treatment method. Included are the steps of refining clays, intercalating organic compounds into the layered structure of clays, drying the intercalated mixture, firing the treated atmospheres and grinding the loosely agglomerated structure. Advanced ceramics produced by this procedure have the advantages of homogeneity, cost effectiveness, simplicity of manufacture, ease of grind and a short process time. Advanced ceramics produced by this process can be used for refractory, wear part and structure ceramics.

  19. Advanced Systems for Monitoring Underwater Sounds

    NASA Technical Reports Server (NTRS)

    Lane, Michael; Van Meter, Steven; Gilmore, Richard Grant; Sommer, Keith

    2007-01-01

    The term "Passive Acoustic Monitoring System" (PAMS) describes a developmental sensing-and-data-acquisition system for recording underwater sounds. The sounds (more precisely, digitized and preprocessed versions from acoustic transducers) are subsequently analyzed by a combination of data processing and interpretation to identify and/or, in some cases, to locate the sources of those sounds. PAMS was originally designed to locate the sources such as fish of species that one knows or seeks to identify. The PAMS unit could also be used to locate other sources, for example, marine life, human divers, and/or vessels. The underlying principles of passive acoustic sensing and analyzing acoustic-signal data in conjunction with temperature and salinity data are not new and not unique to PAMS. Part of the uniqueness of the PAMS design is that it is the first deep-sea instrumentation design to provide a capability for studying soniferous marine animals (especially fish) over the wide depth range described below. The uniqueness of PAMS also lies partly in a synergistic combination of advanced sensing, packaging, and data-processing design features with features adapted from proven marine instrumentation systems. This combination affords a versatility that enables adaptation to a variety of undersea missions using a variety of sensors. The interpretation of acoustic data can include visual inspection of power-spectrum plots for identification of spectral signatures of known biological species or artificial sources. Alternatively or in addition, data analysis could include determination of relative times of arrival of signals at different acoustic sensors arrayed at known locations. From these times of arrival, locations of acoustic sources (and errors in those locations) can be estimated. Estimates of relative locations of sources and sensors can be refined through analysis of the attenuation of sound in the intervening water in combination with water-temperature and salinity

  20. Advances in targeted genome editing.

    PubMed

    Perez-Pinera, Pablo; Ousterout, David G; Gersbach, Charles A

    2012-08-01

    New technologies have recently emerged that enable targeted editing of genomes in diverse systems. This includes precise manipulation of gene sequences in their natural chromosomal context and addition of transgenes to specific genomic loci. This progress has been facilitated by advances in engineering targeted nucleases with programmable, site-specific DNA-binding domains, including zinc finger proteins and transcription activator-like effectors (TALEs). Recent improvements have enhanced nuclease performance, accelerated nuclease assembly, and lowered the cost of genome editing. These advances are driving new approaches to many areas of biotechnology, including biopharmaceutical production, agriculture, creation of transgenic organisms and cell lines, and studies of genome structure, regulation, and function. Genome editing is also being investigated in preclinical and clinical gene therapies for many diseases.