Science.gov

Sample records for advanced image slicer

  1. 3D Slicer as an Image Computing Platform for the Quantitative Imaging Network

    PubMed Central

    Fedorov, Andriy; Beichel, Reinhard; Kalpathy-Cramer, Jayashree; Finet, Julien; Fillion-Robin, Jean-Christophe; Pujol, Sonia; Bauer, Christian; Jennings, Dominique; Fennessy, Fiona; Sonka, Milan; Buatti, John; Aylward, Stephen; Miller, James V.; Pieper, Steve; Kikinis, Ron

    2012-01-01

    Quantitative analysis has tremendous but mostly unrealized potential in healthcare to support objective and accurate interpretation of the clinical imaging. In 2008, the National Cancer Institute began building the Quantitative Imaging Network (QIN) initiative with the goal of advancing quantitative imaging in the context of personalized therapy and evaluation of treatment response. Computerized analysis is an important component contributing to reproducibility and efficiency of the quantitative imaging techniques. The success of quantitative imaging is contingent on robust analysis methods and software tools to bring these methods from bench to bedside. 3D Slicer is a free open source software application for medical image computing. As a clinical research tool, 3D Slicer is similar to a radiology workstation that supports versatile visualizations but also provides advanced functionality such as automated segmentation and registration for a variety of application domains. Unlike a typical radiology workstation, 3D Slicer is free and is not tied to specific hardware. As a programming platform, 3D Slicer facilitates translation and evaluation of the new quantitative methods by allowing the biomedical researcher to focus on the implementation of the algorithm, and providing abstractions for the common tasks of data communication, visualization and user interface development. Compared to other tools that provide aspects of this functionality, 3D Slicer is fully open source and can be readily extended and redistributed. In addition, 3D Slicer is designed to facilitate the development of new functionality in the form of 3D Slicer extensions. In this paper, we present an overview of 3D Slicer as a platform for prototyping, development and evaluation of image analysis tools for clinical research applications. To illustrate the utility of the platform in the scope of QIN, we discuss several use cases of 3D Slicer by the existing QIN teams, and we elaborate on the future

  2. Spectrum slicer for snapshot spectral imaging

    NASA Astrophysics Data System (ADS)

    Tamamitsu, Miu; Kitagawa, Yutaro; Nakagawa, Keiichi; Horisaki, Ryoichi; Oishi, Yu; Morita, Shin-ya; Yamagata, Yutaka; Motohara, Kentaro; Goda, Keisuke

    2015-12-01

    We propose and demonstrate an optical component that overcomes critical limitations in our previously demonstrated high-speed multispectral videography-a method in which an array of periscopes placed in a prism-based spectral shaper is used to achieve snapshot multispectral imaging with the frame rate only limited by that of an image-recording sensor. The demonstrated optical component consists of a slicing mirror incorporated into a 4f-relaying lens system that we refer to as a spectrum slicer (SS). With its simple design, we can easily increase the number of spectral channels without adding fabrication complexity while preserving the capability of high-speed multispectral videography. We present a theoretical framework for the SS and its experimental utility to spectral imaging by showing real-time monitoring of a dynamic colorful event through five different visible windows.

  3. Feasibility study of an image slicer for future space application

    NASA Astrophysics Data System (ADS)

    Calcines, A.; Ichimoto, K.

    2014-08-01

    This communication presents the feasibility study of an image slicer for future space missions, especially for the integral field unit (IFU) of the SUVIT (Solar UV-Visible-IR telescope) spectro-polarimeter on board the Japanese-led solar space mission Solar-C as a backup option. The MuSICa (Multi-Slit Image slicer based on collimator-Camera) image slicer concept, originally developed for the European Solar Telescope, has been adapted to the SUVIT requirements. The IFU will reorganizes a 2-D field of view of 10 x 10 arcsec2 into three slits of 0.18 arcsec width by 185.12 arcsec length using flat slicer mirrors of 100 μm width. The layout of MuSICa for Solar-C is telecentric and offers an optical quality limited by diffraction. The entrance for the SUVIT spectro-polarimeter is composed by the three IFU slits and one ordinal long slit to study, using high resolution spectro-polarimetry, the solar atmosphere (Photosphere and Chromosphere) within a spectral range between 520 nm (optionally 280 nm) and 1,100 nm.

  4. Image slicer manufacturing: from space application to mass production

    NASA Astrophysics Data System (ADS)

    Bonneville, Christophe; Cagnat, Jean-François; Laurent, Florence; Prieto, Eric; Ancourt, Gérard

    2004-09-01

    This presentation aims to show technical and industrial inputs to be taking into account for Image Slicer systems design and development for different types of projects from space application to mass production for multi-IFU instruments. Cybernétix has a strong experience of precision optics assembled thanks to molecular adhesion and have already manufactured 6 prototypes of image slicer subsystem (prototypes of NIRSPEC-IFU, IFS for JWST, MUSE ...) in collaboration with the Laboratoire d"Astrophysique de Marseille (LAM) and the Centre de Recherche Astronomique de Lyon (CRAL). After a brief presentation of the principle of manufacturing and assembly, we will focus on the different performances achieved in our prototypes of slicer mirrors, pupil and slit mirrors lines: an accuracy on centre of curvature position better than 15 arsec has been obtained for a stack of 30 slices. The contribution of the slice stacking to this error is lower than 4 arcsec. In spite of very thin surfaces (~ 0.9 x 40 mm for instance), a special process allows to guarantee a surface roughness about 5 nm and very few digs on the slice borders. The WFE of the mini-mirror can also be measured at a stage of the manufacturing. Different environmental tests have shown the withstanding of these assemblies to cryogenic temperature (30 K). Then, we will describe the different solutions (spherical, flat, cylindrical surfaces) and characteristics of an image slicer that can influence difficulties of manufacturing and metrology, cost, schedule and risks with regard to fabrication. Finally, the study of a mass production plan for MUSE (CRAL) composed of 24 Image Slicers of 38 slices, that"s to say 912 slices, will be exposed as an example of what can be do for multi-module instruments.

  5. Waveguide image-slicers for ultrahigh resolution spectroscopy

    NASA Astrophysics Data System (ADS)

    Beckert, Erik; Strassmeier, Klaus G.; Woche, Manfred; Eberhardt, Ramona; Tünnermann, Andreas; Andersen, Michael

    2008-07-01

    Waveguide image-slicer prototypes with resolutions up to 310.000 for the fiber fed PEPSI echelle spectrograph at the LBT and single waveguide thicknesses of down to 30 μm have been manufactured. The waveguides were macroscopically prepared, stacked up to an order of 7 and thinned back to square stack cross sections. A high filling ratio was achieved by realizing homogenous adhesive gaps of 4.6 μm, using index matching adhesives for TIR within the waveguides. The image-slicer stacks can be used in immersion mode and are miniaturized to be implemented in a set of four, measurements indicate an overall efficiency of above 80% for them.

  6. The Florida Image Slicer for Infrared Astrophysics and Cosmology

    NASA Astrophysics Data System (ADS)

    Raines, S. N.; Eikenberry, S. S.; Guzmán, R.; Gruel, N.; Julian, J.; Boreman, G.; Hoffman, J.; Rodgers, M.; Glenn, P.; Hull-Allen, G.; Myrick, B.; Flint, S.; Comstock, L.

    2007-06-01

    We report on the design, manufacture, and scientific performance of the Florida Image Slicer for Infrared Astrophysics and Cosmology (FISICA), a fully cryogenic all-reflective image slicing integral field unit (IFU) for the FLAMINGOS near-infrared spectrograph (Elston et al.003). We find that FISICA is capable of delivering excellent scientific results. It now operates as a turnkey instrument at the KPNO 4-m telescope via collaboration with the instrument team, who can assist with the proposal preparation and observations, as well as provide the data reduction tools for integral field spectroscopy.

  7. CRAL expertise on image slicer: optical designs, glass or metallic manufacturing, test and results

    NASA Astrophysics Data System (ADS)

    Renault, Edgard; Laurent, Florence; Kosmalski, Johan; Adjali, Louisa

    2008-07-01

    A research and development activity on image slicer systems for integral field spectroscopy has grown in the last years. It allows the simultaneous observation on the same detector matrix of two-dimensional sky maps and a spectral decomposition of light reducing the observation times. Today, image slicers lead to possible applications on future instrumentation for ground-based and space telescopes, covering a spectral domain ranging from blue to mid-IR wavelengths. Since 2001, the Centre de Recherche Astrophysique de Lyon has designed, manufactured, integrated and tested six different breadboards using advanced image slicers. These breadboards are based on different optical designs (three or two mirror arrays or a combination of mirrors and mini-lens arrays). All these designs will be presented. Furthermore, all manufacturing methods will be described. Some use classical polishing approach on Zerodur with an assembling by molecular adhesion. Others are made of metal with monolithic or segmented optical elements and state-of-the-art diamond turning machines. Then all individual tests (roughness, shape and reflectivity) and system performances (alignment and quality image) will be summarized. We will conclude with a comparison between these different breadboards by choosing the most suitable solution for the projects.

  8. FISICA: The Florida image slicer for infrared cosmology and astrophysics

    NASA Astrophysics Data System (ADS)

    Eikenberry, Stephen S.; Elston, Richard; Guzman, Rafael; Raines, S. Nicholas; Julian, J.; Gruel, N.; Boreman, Glenn; Hoffmann, Jeff; Rodgers, Michael; Glenn, Paul; Hull-Allen, Greg; Myrick, Bruce; Flint, Scott; Comstock, Lovell

    2006-06-01

    We report on the design and status of the Florida Image Slicer for Infrared Cosmology and Astrophysics (FISICA) - a fully-cryogenic all-reflective image-slicing integral field unit for the FLAMINGOS near-infrared spectrograph. Designed to accept input beams near f/15, FISICA with FLAMINGOS provides R ˜ 1300 spectra over a 16 × 33″ field-of-view on the Cassegrain f/15 focus of the KPNO 4-m telescope, or a 6 × 12″ field-of-view on the Nasmyth or Bent Cassegrain foci of the Gran Telescopio Canarias 10.4-m telescope. FISICA accomplishes this using three sets of "monolithic" powered mirror arrays, each with 22 mirrored surfaces cut into a single piece of aluminum. We review the optical and opto-mechanical design, fabrication, laboratory test results, and on-telescope performance for FISICA.

  9. FISICA: the Florida image slicer for infrared cosmology and astrophysics

    NASA Astrophysics Data System (ADS)

    Eikenberry, Stephen S.; Elston, Richard; Guzman, Rafael; Julian, Jeff; Raines, S. Nicholas; Gruel, Nicolas; Boreman, Glenn; Glenn, Paul E.; Hull-Allen, C. Gregory; Hoffman, Jeff; Rodgers, Michael; Thompson, Kevin; Flint, Scott; Comstock, Lovell; Myrick, Bruce

    2004-09-01

    We report on the design and status of the Florida Image Slicer for Infrared Cosmology and Astrophysics (FISICA) - a fully-cryogenic all-reflective image-slicing integral field unit for the FLAMINGOS near-infrared spectrograph. Designed to accept input beams near f/15, FISICA with FLAMINGOS provides R~1300 spectra over a 16x33-arcsec field-of-view on the Cassegrain f/15 focus of the KPNO 4-meter telescope, or a 6x12-arcsec field-of-view on the Nasmyth or Bent Cassegrain foci of the Gran Telescopio Canarias 10.4-meter telescope. FISICA accomplishes this using three sets of "monolithic" powered mirror arrays, each with 22 mirrored surfaces cut into a single piece of aluminum. We review the optical and opto-mechanical design and fabrication of FISICA, as well as laboratory test results for FISICA integrated with the FLAMINGOS instrument. We also discuss plans for first-light observations on the KPNO 4-meter telescope in July 2004.

  10. FISICA: the Florida imager slicer for infrared cosmology and astrophysics

    NASA Astrophysics Data System (ADS)

    Eikenberry, Stephen; Raines, S. Nicholas; Gruel, Nicolas; Elston, Richard; Guzman, Rafael; Julian, Jeff; Boreman, Glenn; Glenn, Paul; Hull-Allen, Gregory; Hoffman, Jeffrey; Rodgers, Michael; Thompson, Kevin; Flint, Scott; Comstock, Lovell; Myrick, Bruce

    2006-06-01

    We report on the design, fabrication, and on-sky performance of the Florida Image Slicer for Infrared Cosmology and Astrophysics (FISICA) - a fully-cryogenic all-reflective image-slicing integral field unit for the FLAMINGOS near-infrared spectrograph. Designed to accept input beams near f/15, FISICA with FLAMINGOS provides R~1300 spectra over a 16x33-arcsec field-of-view on the Cassegrain f/15 focus of the KPNO 4-meter telescope, or a 6x12-arcsec field-of-view on the Nasmyth or Bent Cassegrain foci of the Gran Telescopio Canarias 10.4-meter telescope. FISICA accomplishes this using three sets of "monolithic" powered mirror arrays, each with 22 mirrored surfaces cut into a single piece of aluminum. We review the optical and opto-mechanical design and fabrication of FISICA, as well as laboratory test results for FISICA integrated with the FLAMINGOS instrument. Finally, we present performance results from observations with FISICA at the KPNO 4-m telescope and comparisons of FISICA performance to other available IFUs on 4-m to 8-m-class telescopes.

  11. FISICA: The Florida Image Slicer for Infrared Astrophysics and Cosmology

    NASA Astrophysics Data System (ADS)

    Raines, S. N.; Eikenberry, S. S.; Elston, R.; Guzman, R.; Gruel, N.; Julian, J.; Boreman, G.; Hoffman, J.; Rodgers, M.; Glenn, P.; Hull-Allen, G.; Myrick, B.; Flint, S.; Comstock, L.

    2005-12-01

    We report on the design, manufacture, and scientific performance of the Florida Image Slicer for Infrared Astrophysics and Cosmology (FISICA) - a fully cryogenic all-reflective image slicing integral field unit for the FLAMINGOS near-infrared spectrograph. Originally conceived as a bench-top demonstration proof-of-concept instrument, after three productive engineering runs at the KPNO 4-m telescope (as of 15 Oct 2005) we find that FISICA is capable of delivering excellent scientific results. It now operates as a 'turnkey' instrument at the KPNO 4-m telescope. FISICA is now open for community access as a visitor instrument on the KPNO 4-m telescope via collaboration with the instrument team, who can assist with the proposal preparation and observations, as well as provide the data reduction tools for integral field spectroscopy. We review the optical and opto-mechanical design, fabrication, laboratory test results, and on-telescope performance for FISICA. Designed to accept input beams near f/15, FISICA with FLAMINGOS slices a 16x33 arcsec field of view into 22 parallel elements using three sets of monolithic powered mirror arrays, each with 22 mirrored surfaces cut into a single piece of aluminum. However, slight vignetting for some field positions limits the effective field of view to 15x32 arcsec. The effective spatial sampling of 0.70 arcsec delivers 960 spatial resolution elements. Combined with the FLAMINGOS spectrograph, R 1300 spectroscopy over the 1-2.4 micron wavelength range is possible, in either the J+H combined bandpass or the H+K combined bandpass. FISICA was funded by the UCF-UF Space Research Initiative; FLAMINGOS was designed and was constructed by the IR Instrumentation Group (PI: R. Elston) at the University of Florida, Department of Astronomy, with support from NSF grant AST97-31180 and Kitt Peak National Observatory.

  12. Concept and implementation of a virtual image slicer at the VLT

    NASA Astrophysics Data System (ADS)

    Guisard, S.; Sterzik, M.; Muñoz, I.

    2014-07-01

    The concept of "Virtual Image Slicer" was developed and implemented at the Very Large Telescope (VLT). The Virtual Image Slicer consists in elongating the stars in a given direction by the use of the Active Optics of the telescope. Alignment of the major axis of the elongated star along the entrance slit of the spectrograph allows to increase the total signal collected in a single (polarimetric) spectrum by a factor of up to 100 or more relative to a perfectly shaped image for bright sources.

  13. Use of a portable fluorescence imaging device to facilitate cleaning of deli slicers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Cross-contamination is a recognized food safety concern for deli departments, and deli slicers remain a particular concern. Our laboratory previously demonstrated that deli commodity residues can be detected using fluorescence imaging, and that the efficacy of cleaning and sanitation in produce proc...

  14. MuSICa at GRIS: a prototype image slicer for EST at GREGOR

    NASA Astrophysics Data System (ADS)

    Calcines, A.; Collados, M.; López, R. L.

    2013-05-01

    This communication presents a prototype image slicer for the 4-m European Solar Telescope (EST) designed for the spectrograph of the 1.5-m GREGOR solar telescope (GRIS). The design of this integral field unit has been called MuSICa (Multi-Slit Image slicer based on collimator-Camera). It is a telecentric system developed specifically for the integral field, high resolution spectrograph of EST and presents multi-slit capability, reorganizing a bidimensional field of view of 80 arcsec^{2} into 8 slits, each one of them with 200 arcsec length × 0.05 arcsec width. It minimizes the number of optical components needed to fulfil this multi-slit capability, three arrays of mirrors: slicer, collimator and camera mirror arrays (the first one flat and the other two spherical). The symmetry of the layout makes it possible to overlap the pupil images associated to each part of the sliced entrance field of view. A mask with only one circular aperture is placed at the pupil position. This symmetric characteristic offers some advantages: facilitates the manufacturing process, the alignment and reduces the costs. In addition, it is compatible with two modes of operation: spectroscopic and spectro-polarimetric, offering a great versatility. The optical quality of the system is diffraction-limited. The prototype will improve the performances of GRIS at GREGOR and is part of the feasibility study of the integral field unit for the spectrographs of EST. Although MuSICa has been designed as a solar image slicer, its concept can also be applied to night-time astronomical instruments (Collados et al. 2010, Proc. SPIE, Vol. 7733, 77330H; Collados et al. 2012, AN, 333, 901; Calcines et al. 2010, Proc. SPIE, Vol. 7735, 77351X)

  15. MuSICa image slicer prototype at 1.5-m GREGOR solar telescope

    NASA Astrophysics Data System (ADS)

    Calcines, A.; López, R. L.; Collados, M.; Vega Reyes, N.

    2014-07-01

    Integral Field Spectroscopy is an innovative technique that is being implemented in the state-of-the-art instruments of the largest night-time telescopes, however, it is still a novelty for solar instrumentation. A new concept of image slicer, called MuSICa (Multi-Slit Image slicer based on collimator-Camera), has been designed for the integral field spectrograph of the 4-m European Solar Telescope. This communication presents an image slicer prototype of MuSICa for GRIS, the spectrograph of the 1.5-m GREGOR solar telescope located at the Observatory of El Teide. MuSICa at GRIS reorganizes a 2-D field of view of 24.5 arcsec into a slit of 0.367 arcsec width by 66.76 arcsec length distributed horizontally. It will operate together with the TIP-II polarimeter to offer high resolution integral field spectropolarimetry. It will also have a bidimensional field of view scanning system to cover a field of view up to 1 by 1 arcmin.

  16. MuSICa: the Multi-Slit Image Slicer for the est Spectrograph

    NASA Astrophysics Data System (ADS)

    Calcines, A.; López, R. L.; Collados, M.

    2013-09-01

    Integral field spectroscopy (IFS) is a technique that allows one to obtain the spectra of all the points of a bidimensional field of view simultaneously. It is being applied to the new generation of the largest night-time telescopes but it is also an innovative technique for solar physics. This paper presents the design of a new image slicer, MuSICa (Multi-Slit Image slicer based on collimator-Camera), for the integral field spectrograph of the 4-m aperture European Solar Telescope (EST). MuSICa is a multi-slit image slicer that decomposes an 80 arcsec2 field of view into slices of 50 μm and reorganizes it into eight slits of 0.05 arcsec width × 200 arcsec length. It is a telecentric system with an optical quality at diffraction limit compatible with the two modes of operation of the spectrograph: spectroscopic and spectro-polarimetric. This paper shows the requirements, technical characteristics and layout of MuSICa, as well as other studied design options.

  17. SU-E-J-42: Customized Deformable Image Registration Using Open-Source Software SlicerRT

    SciTech Connect

    Gaitan, J Cifuentes; Chin, L; Pignol, J; Kirby, N; Pouliot, J; Lasso, A; Pinter, C; Fichtinger, G

    2014-06-01

    Purpose: SlicerRT is a flexible platform that allows the user to incorporate the necessary images registration and processing tools to improve clinical workflow. This work validates the accuracy and the versatility of the deformable image registration algorithm of the free open-source software SlicerRT using a deformable physical pelvic phantom versus available commercial image fusion algorithms. Methods: Optical camera images of nonradiopaque markers implanted in an anatomical pelvic phantom were used to measure the ground-truth deformation and evaluate the theoretical deformations for several DIR algorithms. To perform the registration, full and empty bladder computed tomography (CT) images of the phantom were obtained and used as fixed and moving images, respectively. The DIR module, found in SlicerRT, used a B-spline deformable image registration with multiple optimization parameters that allowed customization of the registration including a regularization term that controlled the amount of local voxel displacement. The virtual deformation field at the center of the phantom was obtained and compared to the experimental ground-truth values. The parameters of SlicerRT were then varied to improve spatial accuracy. To quantify image similarity, the mean absolute difference (MAD) parameter using Hounsfield units was calculated. In addition, the Dice coefficient of the contoured rectum was evaluated to validate the strength of the algorithm to transfer anatomical contours. Results: Overall, SlicerRT achieved one of the lowest MAD values across the algorithm spectrum, but slightly smaller mean spatial errors in comparison to MIM software (MIM). On the other hand, SlicerRT created higher mean spatial errors than Velocity Medical Solutions (VEL), although obtaining an improvement on the DICE to 0.91. The large spatial errors were attributed to the poor contrast in the prostate bladder interface of the phantom. Conclusion: Based phantom validation, SlicerRT is capable of

  18. Preliminary design of a multi-slit image slicer for EST

    NASA Astrophysics Data System (ADS)

    Calcines, A.; López, R. L.; Collados, M.

    2012-09-01

    Integral field spectroscopy is a modern technique used in Astronomy to obtain simultaneous spectral information of all points in a bidimensional field of view. This communication presents the preliminary design of a multi-slit image slicer to be coupled to the spectrographs of the 4 meters aperture European Solar Telescope. This integral field unit will provide the observation of an 80 arcsec2 field of view, rearranged into 8 slits of 200 arcsec length by 0.05 arcsec width. Different optical design alternatives with diffraction limited optical quality, as well as the design of a prototype for the GREGOR solar telescope, are presented.

  19. S4EI (Spectral Sampling with Slicer for Stellar and Extragalactical Instrumentation), a new-generation of 3D spectro-imager dedicated to night astronomy

    NASA Astrophysics Data System (ADS)

    Sayède, Frédéric; Puech, Mathieu; Mein, Pierre; Bonifacio, Piercarlo; Malherbe, Jean-Marie; Galicher, Raphaël.; Amans, Jean-Philippe; Fasola, Gilles

    2014-07-01

    Multichannel Subtractive Double Pass (MSDP) spectrographs have been widely used in solar spectroscopy because of their ability to provide an excellent compromise between field of view and spatial and spectral resolutions. Compared with other types of spectrographs, MSDP can deliver simultaneous monochromatic images at higher spatial and spectral resolutions without any time-scanning requirement (as with Fabry-Perot spectrographs), and with limited loss of flux. These performances are obtained thanks to a double pass through the dispersive element. Recent advances with VPH (Volume phase holographic) Grisms as well as with image slicers now make MSDP potentially sensitive to much smaller fluxes. We present S4EI (Spectral Sampling with Slicer for Stellar and Extragalactical Instrumentation), which is a new concept for extending MSDP to night-time astronomy. It is based on new generation reflecting plane image slicers working with large apertures specific to night-time telescopes. The resulting design could be potentially very attractive and innovative for different domains of astronomy, e.g., the simultaneous spatial mapping of accurately flux-calibrated emission lines between OH sky lines in extragalactic astronomy or the simultaneous imaging of stars, exoplanets and interstellar medium. We present different possible MSDP/S4EI configurations for these science cases and expected performances on telescopes such as the VLT.

  20. The S4I prototype: a beam-slicer system dedicated to the new generation multichannel subtractive double pass for EST imaging spectropolarimetry

    NASA Astrophysics Data System (ADS)

    Sayède, Frédéric; Mein, Pierre; Amans, Jean-Philippe; Moity, Jacques

    2012-09-01

    For the future European Solar Telescope (EST) the Observatoire de Paris proposes a new generation of MSDP: an imaging spectro-polarimetry instrument. To validate this new generation, we develop a beam slicer prototype that will be tested and validated on an optical bench and on existing telescopes. The prototype called S4I (Spectral Sampling with Slicer for Solar Instrumentation) is under construction and tested at the Observatoire de Paris. It validates the opto-mechanical feasibility of the new beam slicer. The manufacture is now complete: we give a description of the whole system. We give also some results of the first tests.

  1. The S4I prototype, a beam-slicer dedicated to the new generation Multichannel Subtractive Double Pass for EST imaging spectropolarimetry

    NASA Astrophysics Data System (ADS)

    Sayède, Frédéric; Mein, Pierre; Malherbe, Jean-Marie; Amans, Jean-Philippe; Crussaire, Daniel; Lecocguen, Regis

    2014-08-01

    For the future European Solar Telescope (EST) the Observatoire de Paris proposes a new generation of MSDP, an imaging spectro-polarimetry instrument. To validate this new generation, we develop a plane micro-mirrors beam slicer prototype that is tested and validated on an optical bench and on existing telescopes. The prototype called S4I (Spectral Sampling with Slicer for Solar Instrumentation) is built and tested at the Observatoire de Paris. It validates the opto-mechanical feasibility of the new beam slicer. After a complete description of the system, we present the first images. We evaluate the performances of the prototype and compare them to the requirements for the beam-slicer dedicated to the future EST.

  2. Exploring high contrast limitations for image slicer-based integral field spectrographs

    NASA Astrophysics Data System (ADS)

    Salter, Graeme; Thatte, Niranjan; Tecza, Matthias; Clarke, Fraser; Verinaud, Christophe; Kasper, Markus; Abuter, Roberto

    2008-07-01

    Current simulation and experimental investigatory work is going on into the performance of slicer and lenslet IFS designs. The aim of this work is to determine which technology holds the best promise for achieving the highest contrasts with EPICS on the E-ELT. Results from Spectral Deconvolution methods for high contrast detections are presented, both on sky images from AB Dor C observations using SINFONI on the VLT and improvements to the algorithms made through use of EPICS simulation data. Using these simulations, only containing photon and speckle noise, we have been able to detect simulated planets down to a contrast of 1010 located less than 1" from the parent star. The effects of spectral resolution and wavelength range on high contrast observations are discussed. Shortening the wavelength range increases the inner working angle. It is seen that an outer working angle is also reached that decreases with spectral resolution. The limit on the inner working angle can be overcome partly by increasing the wavelength range of the instrument although another inner working angle limit will be reached if a coronagraph is used. The limit of the outer working angle can also be overcome by increasing the spectral resolution of the instrument or possibly by making an IFS that produces an output with a constant spectral resolution, R, instead of constant Δλ. This is still a work in progress.

  3. GBM Volumetry using the 3D Slicer Medical Image Computing Platform

    PubMed Central

    Egger, Jan; Kapur, Tina; Fedorov, Andriy; Pieper, Steve; Miller, James V.; Veeraraghavan, Harini; Freisleben, Bernd; Golby, Alexandra J.; Nimsky, Christopher; Kikinis, Ron

    2013-01-01

    Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer – a free platform for biomedical research – provides an alternative to this manual slice-by-slice segmentation process, which is significantly faster and requires less user interaction. In this study, 4 physicians segmented GBMs in 10 patients, once using the competitive region-growing based GrowCut segmentation module of Slicer, and once purely by drawing boundaries completely manually on a slice-by-slice basis. Furthermore, we provide a variability analysis for three physicians for 12 GBMs. The time required for GrowCut segmentation was on an average 61% of the time required for a pure manual segmentation. A comparison of Slicer-based segmentation with manual slice-by-slice segmentation resulted in a Dice Similarity Coefficient of 88.43 ± 5.23% and a Hausdorff Distance of 2.32 ± 5.23 mm. PMID:23455483

  4. Deformable image registration with a featurelet algorithm: implementation as a 3D-slicer extension and validation

    NASA Astrophysics Data System (ADS)

    Renner, A.; Furtado, H.; Seppenwoolde, Y.; Birkfellner, W.; Georg, D.

    2016-03-01

    A radiotherapy (RT) treatment can last for several weeks. In that time organ motion and shape changes introduce uncertainty in dose application. Monitoring and quantifying the change can yield a more precise irradiation margin definition and thereby reduce dose delivery to healthy tissue and adjust tumor targeting. Deformable image registration (DIR) has the potential to fulfill this task by calculating a deformation field (DF) between a planning CT and a repeated CT of the altered anatomy. Application of the DF on the original contours yields new contours that can be used for an adapted treatment plan. DIR is a challenging method and therefore needs careful user interaction. Without a proper graphical user interface (GUI) a misregistration cannot be easily detected by visual inspection and the results cannot be fine-tuned by changing registration parameters. To provide a DIR algorithm with such a GUI available for everyone, we created the extension Featurelet-Registration for the open source software platform 3D Slicer. The registration logic is an upgrade of an in-house-developed DIR method, which is a featurelet-based piecewise rigid registration. The so called "featurelets" are equally sized rectangular subvolumes of the moving image which are rigidly registered to rectangular search regions on the fixed image. The output is a deformed image and a deformation field. Both can be visualized directly in 3D Slicer facilitating the interpretation and quantification of the results. For validation of the registration accuracy two deformable phantoms were used. The performance was benchmarked against a demons algorithm with comparable results.

  5. Design, fabrication, assembly, and testing of the Florida image slicer for infrared cosmology and astrophysics (FISICA) integral field unit

    NASA Astrophysics Data System (ADS)

    Glenn, Paul E.; Hull-Allen, C. Gregory; Hoffman, Jeff; Rodgers, Michael; Thompson, Kevin; Myrick, Bruce; Comstock, Lovell; Flint, Scott; Boreman, Glenn; Eikenberry, Stephen S.; Elston, Richard; Guzman, Rafael; Julian, Jeff; Raines, S. Nicholas

    2004-09-01

    We discuss the design, fabrication, assembly, and testing of the prototype Florida Image Slicer for Infrared Cosmology and Astrophysics (FISICA) Integral Field Unit (IFU). FISICA is intended for large telescopes with f/numbers close to f/15, such as the KPNO 4-m and GTC 10.4-m telescopes. It implements an image slicing approach, wherein the initial image plane is optically sliced into thin strips and the strips are optically rearranged end-to-end, whereupon the composite slit image is fed into a conventional spectrograph. We divide the field of view into 22 slices, while accommodating the entire f/15 viewing solid angle. The all-reflective instrument resides in a cryogenic dewar at the initial focal plane, and places the composite slit image output precisely at the initial focus, allowing it to interface to the existing FLAMINGOS spectrograph. The mirrors were diamond turned using various tool geometries and state-of-the-art, multi-axis tool control. The mirrors are made from a single billet of aluminum, and the optical bench and mounts are made of the same alloy as the mirrors for optimum performance during cryogenic cooling. We discuss the key design efforts, emphasizing tradeoffs among performance, volume, fabrication difficulty, and alignment requirements. We describe the fabrication, and present preliminary laboratory test results.

  6. Deployable Integral Field Units, Multislits, and Image Slicer for the Goodman Imaging Spectrograph on the SOAR Telescope

    NASA Astrophysics Data System (ADS)

    Cecil, Gerald N.; Moffett, A. J.; Cui, Y.; Eckert, K. D.; McBride, J.; Kannappan, S.; Keller, K.; Barlow, B. N.; Dunlap, B.; Bland-Hawthorn, J.

    2010-01-01

    The Goodman Imager-Spectrograph on the 4.1m SOAR telescope has operated on Cerro Pachon, Chile with volume-phase holographic gratings in long-slit mode since its commissioning in 2008. Recently, UNC graduate students played key roles to implement robust upgrades for multi-object spectroscopy that will soon be available to US astronomers through the NOAO time share on SOAR: • Multislits over 3x5 arcmin, generated on PCB solder stencils with exceptional sharpness compared to conventional laser cuts, initially to survey globular clusters for pulsating hot sub-dwarfs • An image slicer to obtain 3 simultaneous parallel spectra 70-arcsec long, 1- or 2-arcsec wide, spanning 320-750 nm to map stellar and gaseous emission and mass over the 1500 galaxies in the RESOLVE survey underway on SOAR • Four integral field units, each composed of 5-arcsec diameter, fused bundles of 0.5-arcsec diameter thin-clad optical fiber, independently deployed over a 10x5 arcmin field targeted by an EMCCD also used for Lucky Imaging. Initially will study aperture effects in single fiber surveys, extragalactic globular clusters, and demonstrate technology prior to deployment on larger telescopes • New wheels supporting a large set of existing narrow-band and Sloan filters • A trombone-style atmospheric dispersion compensator that corrects the full 12-arcmin diameter science field down to 30 deg elevation. Working in UNC's Goodman Laboratory for Astronomical Instrumentation, students employed SolidWorks and ZEMAX to design parts for in-house CAM on CNC machines and a 3D printer. All motors are controlled by LabVIEW as is the SOAR TCS. The deployable IFU axes are controlled by Quicksilver Controls Inc. intelligent servos and $80 model robot (Firgelli Corp.) actuators driven by a PIC-microcontroller and a student designed custom PCB. Upgrades and students were supported by $200K from SOAR Corporation, Research Corporation, NSF, and UNC competitive funds, and NC NASA Space Grant, Sigma Xi

  7. Pituitary Adenoma Volumetry with 3D Slicer

    PubMed Central

    Nimsky, Christopher; Kikinis, Ron

    2012-01-01

    In this study, we present pituitary adenoma volumetry using the free and open source medical image computing platform for biomedical research: (3D) Slicer. Volumetric changes in cerebral pathologies like pituitary adenomas are a critical factor in treatment decisions by physicians and in general the volume is acquired manually. Therefore, manual slice-by-slice segmentations in magnetic resonance imaging (MRI) data, which have been obtained at regular intervals, are performed. In contrast to this manual time consuming slice-by-slice segmentation process Slicer is an alternative which can be significantly faster and less user intensive. In this contribution, we compare pure manual segmentations of ten pituitary adenomas with semi-automatic segmentations under Slicer. Thus, physicians drew the boundaries completely manually on a slice-by-slice basis and performed a Slicer-enhanced segmentation using the competitive region-growing based module of Slicer named GrowCut. Results showed that the time and user effort required for GrowCut-based segmentations were on average about thirty percent less than the pure manual segmentations. Furthermore, we calculated the Dice Similarity Coefficient (DSC) between the manual and the Slicer-based segmentations to proof that the two are comparable yielding an average DSC of 81.97±3.39%. PMID:23240062

  8. MR diffusion-weighted imaging-based subcutaneous tumour volumetry in a xenografted nude mouse model using 3D Slicer: an accurate and repeatable method

    PubMed Central

    Ma, Zelan; Chen, Xin; Huang, Yanqi; He, Lan; Liang, Cuishan; Liang, Changhong; Liu, Zaiyi

    2015-01-01

    Accurate and repeatable measurement of the gross tumour volume(GTV) of subcutaneous xenografts is crucial in the evaluation of anti-tumour therapy. Formula and image-based manual segmentation methods are commonly used for GTV measurement but are hindered by low accuracy and reproducibility. 3D Slicer is open-source software that provides semiautomatic segmentation for GTV measurements. In our study, subcutaneous GTVs from nude mouse xenografts were measured by semiautomatic segmentation with 3D Slicer based on morphological magnetic resonance imaging(mMRI) or diffusion-weighted imaging(DWI)(b = 0,20,800 s/mm2) . These GTVs were then compared with those obtained via the formula and image-based manual segmentation methods with ITK software using the true tumour volume as the standard reference. The effects of tumour size and shape on GTVs measurements were also investigated. Our results showed that, when compared with the true tumour volume, segmentation for DWI(P = 0.060–0.671) resulted in better accuracy than that mMRI(P < 0.001) and the formula method(P < 0.001). Furthermore, semiautomatic segmentation for DWI(intraclass correlation coefficient, ICC = 0.9999) resulted in higher reliability than manual segmentation(ICC = 0.9996–0.9998). Tumour size and shape had no effects on GTV measurement across all methods. Therefore, DWI-based semiautomatic segmentation, which is accurate and reproducible and also provides biological information, is the optimal GTV measurement method in the assessment of anti-tumour treatments. PMID:26489359

  9. Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience.

    PubMed

    Kapur, Tina; Pieper, Steve; Fedorov, Andriy; Fillion-Robin, J-C; Halle, Michael; O'Donnell, Lauren; Lasso, Andras; Ungi, Tamas; Pinter, Csaba; Finet, Julien; Pujol, Sonia; Jagadeesan, Jayender; Tokuda, Junichi; Norton, Isaiah; Estepar, Raul San Jose; Gering, David; Aerts, Hugo J W L; Jakab, Marianna; Hata, Nobuhiko; Ibanez, Luiz; Blezek, Daniel; Miller, Jim; Aylward, Stephen; Grimson, W Eric L; Fichtinger, Gabor; Wells, William M; Lorensen, William E; Schroeder, Will; Kikinis, Ron

    2016-10-01

    The National Alliance for Medical Image Computing (NA-MIC) was launched in 2004 with the goal of investigating and developing an open source software infrastructure for the extraction of information and knowledge from medical images using computational methods. Several leading research and engineering groups participated in this effort that was funded by the US National Institutes of Health through a variety of infrastructure grants. This effort transformed 3D Slicer from an internal, Boston-based, academic research software application into a professionally maintained, robust, open source platform with an international leadership and developer and user communities. Critical improvements to the widely used underlying open source libraries and tools-VTK, ITK, CMake, CDash, DCMTK-were an additional consequence of this effort. This project has contributed to close to a thousand peer-reviewed publications and a growing portfolio of US and international funded efforts expanding the use of these tools in new medical computing applications every year. In this editorial, we discuss what we believe are gaps in the way medical image computing is pursued today; how a well-executed research platform can enable discovery, innovation and reproducible science ("Open Science"); and how our quest to build such a software platform has evolved into a productive and rewarding social engineering exercise in building an open-access community with a shared vision.

  10. Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience.

    PubMed

    Kapur, Tina; Pieper, Steve; Fedorov, Andriy; Fillion-Robin, J-C; Halle, Michael; O'Donnell, Lauren; Lasso, Andras; Ungi, Tamas; Pinter, Csaba; Finet, Julien; Pujol, Sonia; Jagadeesan, Jayender; Tokuda, Junichi; Norton, Isaiah; Estepar, Raul San Jose; Gering, David; Aerts, Hugo J W L; Jakab, Marianna; Hata, Nobuhiko; Ibanez, Luiz; Blezek, Daniel; Miller, Jim; Aylward, Stephen; Grimson, W Eric L; Fichtinger, Gabor; Wells, William M; Lorensen, William E; Schroeder, Will; Kikinis, Ron

    2016-10-01

    The National Alliance for Medical Image Computing (NA-MIC) was launched in 2004 with the goal of investigating and developing an open source software infrastructure for the extraction of information and knowledge from medical images using computational methods. Several leading research and engineering groups participated in this effort that was funded by the US National Institutes of Health through a variety of infrastructure grants. This effort transformed 3D Slicer from an internal, Boston-based, academic research software application into a professionally maintained, robust, open source platform with an international leadership and developer and user communities. Critical improvements to the widely used underlying open source libraries and tools-VTK, ITK, CMake, CDash, DCMTK-were an additional consequence of this effort. This project has contributed to close to a thousand peer-reviewed publications and a growing portfolio of US and international funded efforts expanding the use of these tools in new medical computing applications every year. In this editorial, we discuss what we believe are gaps in the way medical image computing is pursued today; how a well-executed research platform can enable discovery, innovation and reproducible science ("Open Science"); and how our quest to build such a software platform has evolved into a productive and rewarding social engineering exercise in building an open-access community with a shared vision. PMID:27498015

  11. Nicer-slicer-dicer: an interactive volume visualization tool

    NASA Astrophysics Data System (ADS)

    Moran, Patrick J.

    1994-04-01

    Nicer-Slicer-Dicer (NSD) is a new, interactive tool for volume visualization. In addition to single scalar volumes, NSD can visualize multivariate and time series data. NSD achieves high rendering rates by compositing slice planes back-to-front while blending pixels through the use of alpha buffering hardware. This technique introduces some small artifacts, but it works remarkably well with large data sets where voxels represent small areas in image space. The plane compositing technique also allows one to generate an isosurface and volume rendering simultaneously by interleaving planes and isosurface polygons.

  12. Morphological and Volumetric Assessment of Cerebral Ventricular System with 3D Slicer Software.

    PubMed

    Gonzalo Domínguez, Miguel; Hernández, Cristina; Ruisoto, Pablo; Juanes, Juan A; Prats, Alberto; Hernández, Tomás

    2016-06-01

    We present a technological process based on the 3D Slicer software for the three-dimensional study of the brain's ventricular system with teaching purposes. It values the morphology of this complex brain structure, as a whole and in any spatial position, being able to compare it with pathological studies, where its anatomy visibly changes. 3D Slicer was also used to obtain volumetric measurements in order to provide a more comprehensive and detail representation of the ventricular system. We assess the potential this software has for processing high resolution images, taken from Magnetic Resonance and generate the three-dimensional reconstruction of ventricular system. PMID:27147517

  13. Advanced imaging system

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This document describes the Advanced Imaging System CCD based camera. The AIS1 camera system was developed at Photometric Ltd. in Tucson, Arizona as part of a Phase 2 SBIR contract No. NAS5-30171 from the NASA/Goddard Space Flight Center in Greenbelt, Maryland. The camera project was undertaken as a part of the Space Telescope Imaging Spectrograph (STIS) project. This document is intended to serve as a complete manual for the use and maintenance of the camera system. All the different parts of the camera hardware and software are discussed and complete schematics and source code listings are provided.

  14. SLICER Airborne Laser Altimeter Characterization of Canopy Structure and Sub-canopy Topography for the BOREAS Northern and Southern Study Regions: Instrument and Data Product Description

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Harding, D. J.; Blair, J. B.; Rabine, D. L.; Still, K. L.

    2000-01-01

    SLICER data were acquired in support of BOREAS at all of the TF sites in the SSA and NSA, and along transects between the study areas. Data were acquired on 5 days between 18-Jul and 30-Jul-1996. Each coverage of a tower site is typically 40 km in length, with a minimum of 3 and a maximum of 10 lines across each tower oriented in a variety of azimuths. The SLICER data were acquired simultaneously with ASAS hyperspectral, multiview angle images. The SLICER Level 3 products consist of binary files for each flight line with a data record for each laser shot composed of 13 parameters and a 600-byte waveform that is the raw record of the backscatter laser energy reflected from Earth's surface. The SLICER data are stored in a combination of ASCII and binary data files.

  15. Enabling ITK-based processing and 3D Slicer MRML scene management in ParaView.

    PubMed

    Enquobahrie, Andinet; Bowers, Michael; Ibanez, Luis; Finet, Julien; Audette, Michel; Kolasny, Anthony

    2012-02-28

    This paper documents on-going work to facilitate ITK-based processing and 3D Slicer scene management in ParaView. We believe this will broaden the use of ParaView for high performance computing and visualization in the medical imaging research community. The effort is focused on developing ParaView plug-ins for managing VTK structures from 3D Slicer MRML scenes and encapsulating ITK filters for deployment in ParaView. In this paper, we present KWScene, an open source cross-platform library that is being developed to support implementation of these types of plugins. We describe the overall design of the library and provide implementation details and conclude by presenting a concrete example that demonstrates the use of the KWScene library in computational anatomy research at Johns Hopkins Center for Imaging Science.

  16. Advanced laser image recorder.

    PubMed

    Gramenopoulos, N; Hartfield, E D

    1972-12-01

    A laser image recorder is described, which is unique because of its advanced design and the state-of-the-art components employed to achieve high performance and versatility. The critical components are the pyramidal mirror scanner and the beam focusing lens. The scanner has a six-facet, beryllium mirror accurate to 0.33 sec of arc and rotating at 0-50,000 rpm on air bearings. A rapid change in speed is an important feature of this scanner. The focusing lens is diffraction limited with a flat field of 54 degrees , allowing a 90% duty cycle and the use of photographic film transported by a cylindrical drum. The lens converts the constant angular velocity of the reflected beam to a constant scanning velocity of the focused spot with a linearity of 0.05%. Maximum number of picture elements per line is 36,800 over a format of 228.6 mm. PMID:20119408

  17. Patch-clamp recording in brain slices with improved slicer technology.

    PubMed

    Geiger, J R P; Bischofberger, J; Vida, I; Fröbe, U; Pfitzinger, S; Weber, H J; Haverkampf, K; Jonas, P

    2002-01-01

    The use of advanced patch-clamp recording techniques in brain slices, such as simultaneous recording from multiple neurons and recording from dendrites or presynaptic terminals, demands slices of the highest quality. In this context the mechanics of the tissue slicer are an important factor. Ideally, a tissue slicer should generate large-amplitude and high-frequency movements of the cutting blade in a horizontal axis, with minimal vibrations in the vertical axis. We developed a vibroslicer that fulfils these in part conflicting requirements. The oscillator is a permanent-magnet-coil-leaf-spring system. Using an auto-resonant mechano-electrical feedback circuit, large horizontal oscillations (up to 3 mm peak-to-peak) with high frequency ( approximately 90 Hz) are generated. To minimize vertical vibrations, an adjustment mechanism was employed that allowed alignment of the cutting edge of the blade with the major axis of the oscillation. A vibroprobe device was used to monitor vertical vibrations during adjustment. The system is based on the shading of the light path between a light-emitting diode (LED) and a photodiode. Vibroprobe monitoring revealed that the vibroslicer, after appropriate adjustment, generated vertical vibrations of <1 microm, significantly less than many commercial tissue slicers. Light- and electron-microscopic analysis of surface layers of slices cut with the vibroslicer showed that cellular elements, dendritic processes and presynaptic terminals are well preserved under these conditions, as required for patch-clamp recording from these structures. PMID:11810221

  18. Advancing biomedical imaging

    PubMed Central

    Weissleder, Ralph; Nahrendorf, Matthias

    2015-01-01

    Imaging reveals complex structures and dynamic interactive processes, located deep inside the body, that are otherwise difficult to decipher. Numerous imaging modalities harness every last inch of the energy spectrum. Clinical modalities include magnetic resonance imaging (MRI), X-ray computed tomography (CT), ultrasound, and light-based methods [endoscopy and optical coherence tomography (OCT)]. Research modalities include various light microscopy techniques (confocal, multiphoton, total internal reflection, superresolution fluorescence microscopy), electron microscopy, mass spectrometry imaging, fluorescence tomography, bioluminescence, variations of OCT, and optoacoustic imaging, among a few others. Although clinical imaging and research microscopy are often isolated from one another, we argue that their combination and integration is not only informative but also essential to discovering new biology and interpreting clinical datasets in which signals invariably originate from hundreds to thousands of cells per voxel. PMID:26598657

  19. Advanced image memory architecture

    NASA Astrophysics Data System (ADS)

    Vercillo, Richard; McNeill, Kevin M.

    1994-05-01

    A workstation for radiographic images, known as the Arizona Viewing Console (AVC), was developed at the University of Arizona Health Sciences Center in the Department of Radiology. This workstation has been in use as a research tool to aid us in investigating how a radiologist interacts with a workstation, to determine which image processing features are required to aid the radiologist, to develop user interfaces and to support psychophysical and clinical studies. Results from these studies have show a need to increase the current image memory's available storage in order to accommodate high resolution images. The current triple-ported image memory can be allocated to store any number of images up to a combined total of 4 million pixels. Over the past couple of years, higher resolution images have become easier to generate with the advent of laser digitizers and computed radiology systems. As part of our research, a larger 32 million pixel image memory for AVC has been designed to replace the existing image memory.

  20. Modern Imaging Technology: Recent Advances

    SciTech Connect

    Welch, Michael J.; Eckelman, William C.

    2004-06-18

    This 2-day conference is designed to bring scientist working in nuclear medicine, as well as nuclear medicine practitioners together to discuss the advances in four selected areas of imaging: Biochemical Parameters using Small Animal Imaging, Developments in Small Animal PET Imaging, Cell Labeling, and Imaging Angiogenesis Using Multiple Modality. The presentations will be on molecular imaging applications at the forefront of research, up to date on the status of molecular imaging in nuclear medicine as well as in related imaging areas. Experts will discuss the basic science of imaging techniques, and scheduled participants will engage in an exciting program that emphasizes the current status of molecular imaging as well as the role of DOE funded research in this area.

  1. Advanced imaging communication system

    NASA Technical Reports Server (NTRS)

    Hilbert, E. E.; Rice, R. F.

    1977-01-01

    Key elements of system are imaging and nonimaging sensors, data compressor/decompressor, interleaved Reed-Solomon block coder, convolutional-encoded/Viterbi-decoded telemetry channel, and Reed-Solomon decoding. Data compression provides efficient representation of sensor data, and channel coding improves reliability of data transmission.

  2. Advanced Land Imager Assessment System

    NASA Technical Reports Server (NTRS)

    Chander, Gyanesh; Choate, Mike; Christopherson, Jon; Hollaren, Doug; Morfitt, Ron; Nelson, Jim; Nelson, Shar; Storey, James; Helder, Dennis; Ruggles, Tim; Kaita, Ed; Levy, Raviv; Ong, Lawrence; Markham, Brian; Schweiss, Robert

    2008-01-01

    The Advanced Land Imager Assessment System (ALIAS) supports radiometric and geometric image processing for the Advanced Land Imager (ALI) instrument onboard NASA s Earth Observing-1 (EO-1) satellite. ALIAS consists of two processing subsystems for radiometric and geometric processing of the ALI s multispectral imagery. The radiometric processing subsystem characterizes and corrects, where possible, radiometric qualities including: coherent, impulse; and random noise; signal-to-noise ratios (SNRs); detector operability; gain; bias; saturation levels; striping and banding; and the stability of detector performance. The geometric processing subsystem and analysis capabilities support sensor alignment calibrations, sensor chip assembly (SCA)-to-SCA alignments and band-to-band alignment; and perform geodetic accuracy assessments, modulation transfer function (MTF) characterizations, and image-to-image characterizations. ALIAS also characterizes and corrects band-toband registration, and performs systematic precision and terrain correction of ALI images. This system can geometrically correct, and automatically mosaic, the SCA image strips into a seamless, map-projected image. This system provides a large database, which enables bulk trending for all ALI image data and significant instrument telemetry. Bulk trending consists of two functions: Housekeeping Processing and Bulk Radiometric Processing. The Housekeeping function pulls telemetry and temperature information from the instrument housekeeping files and writes this information to a database for trending. The Bulk Radiometric Processing function writes statistical information from the dark data acquired before and after the Earth imagery and the lamp data to the database for trending. This allows for multi-scene statistical analyses.

  3. Advances in multimodality molecular imaging

    PubMed Central

    Zaidi, Habib; Prasad, Rameshwar

    2009-01-01

    Multimodality molecular imaging using high resolution positron emission tomography (PET) combined with other modalities is now playing a pivotal role in basic and clinical research. The introduction of combined PET/CT systems in clinical setting has revolutionized the practice of diagnostic imaging. The complementarity between the intrinsically aligned anatomic (CT) and functional or metabolic (PET) information provided in a “one-stop shop” and the possibility to use CT images for attenuation correction of the PET data has been the driving force behind the success of this technology. On the other hand, combining PET with Magnetic Resonance Imaging (MRI) in a single gantry is technically more challenging owing to the strong magnetic fields. Nevertheless, significant progress has been made resulting in the design of few preclinical PET systems and one human prototype dedicated for simultaneous PET/MR brain imaging. This paper discusses recent advances in PET instrumentation and the advantages and challenges of multimodality imaging systems. Future opportunities and the challenges facing the adoption of multimodality imaging instrumentation will also be addressed. PMID:20098557

  4. Retail Deli Slicer Cleaning Frequency--Six Selected Sites, United States, 2012.

    PubMed

    Brown, Laura G; Hoover, E Rickamer; Ripley, Danny; Matis, Bailey; Nicholas, David; Hedeen, Nicole; Faw, Brenda

    2016-01-01

    Listeria monocytogenes (Listeria) causes the third highest number of foodborne illness deaths (an estimated 255) in the United States annually, after nontyphoidal Salmonella species and Toxoplasma gondii (1). Deli meats are a major source of listeriosis illnesses, and meats sliced and packaged at retail delis are the major source of listeriosis illnesses attributed to deli meat (4). Mechanical slicers pose cross-contamination risks in delis and are an important source of Listeria cross-contamination. Reducing Listeria contamination of sliced meats in delis will likely reduce Listeria illnesses and outbreaks. Good slicer cleaning practices can reduce this foodborne illness risk. CDC's Environmental Health Specialists Network (EHS-Net) studied how often retail deli slicers were fully cleaned (disassembled, cleaned, and sanitized) at the Food and Drug Administration (FDA) Food Code-specified minimum frequency of every 4 hours and examined deli and staff characteristics related to slicer cleaning frequency. Interviews with staff members in 298 randomly-selected delis in six EHS-Net sites showed that approximately half of delis fully cleaned their slicers less often than FDA's specified minimum frequency. Chain-owned delis and delis with more customers, more slicers, required manager food safety training, food safety-knowledgeable workers, written slicer-cleaning policies, and food safety-certified managers fully cleaned their slicers more frequently than did other types of delis, according to deli managers or workers. States and localities should require deli manager training and certification, as specified in the FDA Food Code. They should also consider encouraging or requiring delis to have written slicer-cleaning policies. Retail food industry leaders can also implement these prevention efforts to reduce risk in their establishments. Because independent and smaller delis had lower frequencies of slicer cleaning, prevention efforts should focus on these types of

  5. Recent advances in imaging technologies in dentistry

    PubMed Central

    Shah, Naseem; Bansal, Nikhil; Logani, Ajay

    2014-01-01

    Dentistry has witnessed tremendous advances in all its branches over the past three decades. With these advances, the need for more precise diagnostic tools, specially imaging methods, have become mandatory. From the simple intra-oral periapical X-rays, advanced imaging techniques like computed tomography, cone beam computed tomography, magnetic resonance imaging and ultrasound have also found place in modern dentistry. Changing from analogue to digital radiography has not only made the process simpler and faster but also made image storage, manipulation (brightness/contrast, image cropping, etc.) and retrieval easier. The three-dimensional imaging has made the complex cranio-facial structures more accessible for examination and early and accurate diagnosis of deep seated lesions. This paper is to review current advances in imaging technology and their uses in different disciplines of dentistry. PMID:25349663

  6. Advanced Pointing Imaging Camera (APIC) Concept

    NASA Astrophysics Data System (ADS)

    Park, R. S.; Bills, B. G.; Jorgensen, J.; Jun, I.; Maki, J. N.; McEwen, A. S.; Riedel, E.; Walch, M.; Watkins, M. M.

    2016-10-01

    The Advanced Pointing Imaging Camera (APIC) concept is envisioned as an integrated system, with optical bench and flight-proven components, designed for deep-space planetary missions with 2-DOF control capability.

  7. Recent Advancements in Microwave Imaging Plasma Diagnostics

    SciTech Connect

    H. Park; C.C. Chang; B.H. Deng; C.W. Domier; A.J.H. Donni; K. Kawahata; C. Liang; X.P. Liang; H.J. Lu; N.C. Luhmann, Jr.; A. Mase; H. Matsuura; E. Mazzucato; A. Miura; K. Mizuno; T. Munsat; K. and Y. Nagayama; M.J. van de Pol; J. Wang; Z.G. Xia; W-K. Zhang

    2002-03-26

    Significant advances in microwave and millimeter wave technology over the past decade have enabled the development of a new generation of imaging diagnostics for current and envisioned magnetic fusion devices. Prominent among these are revolutionary microwave electron cyclotron emission imaging (ECEI), microwave phase imaging interferometers, imaging microwave scattering and microwave imaging reflectometer (MIR) systems for imaging electron temperature and electron density fluctuations (both turbulent and coherent) and profiles (including transport barriers) on toroidal devices such as tokamaks, spherical tori, and stellarators. The diagnostic technology is reviewed, and typical diagnostic systems are analyzed. Representative experimental results obtained with these novel diagnostic systems are also presented.

  8. Microscopy imaging device with advanced imaging properties

    SciTech Connect

    Ghosh, Kunal; Burns, Laurie; El Gamal, Abbas; Schnitzer, Mark J.; Cocker, Eric; Ho, Tatt Wei

    2015-11-24

    Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 .mu.m resolution for an image of the field of view.

  9. Microscopy imaging device with advanced imaging properties

    DOEpatents

    Ghosh, Kunal; Burns, Laurie; El Gamal, Abbas; Schnitzer, Mark J.; Cocker, Eric; Ho, Tatt Wei

    2016-10-25

    Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 .mu.m resolution for an image of the field of view.

  10. Desktop supercomputers. Advance medical imaging.

    PubMed

    Frisiello, R S

    1991-02-01

    Medical imaging tools that radiologists as well as a wide range of clinicians and healthcare professionals have come to depend upon are emerging into the next phase of functionality. The strides being made in supercomputing technologies--including reduction of size and price--are pushing medical imaging to a new level of accuracy and functionality.

  11. Advanced Imaging Algorithms for Radiation Imaging Systems

    SciTech Connect

    Marleau, Peter

    2015-10-01

    The intent of the proposed work, in collaboration with University of Michigan, is to develop the algorithms that will bring the analysis from qualitative images to quantitative attributes of objects containing SNM. The first step to achieving this is to develop an indepth understanding of the intrinsic errors associated with the deconvolution and MLEM algorithms. A significant new effort will be undertaken to relate the image data to a posited three-dimensional model of geometric primitives that can be adjusted to get the best fit. In this way, parameters of the model such as sizes, shapes, and masses can be extracted for both radioactive and non-radioactive materials. This model-based algorithm will need the integrated response of a hypothesized configuration of material to be calculated many times. As such, both the MLEM and the model-based algorithm require significant increases in calculation speed in order to converge to solutions in practical amounts of time.

  12. Volumetric CT-based segmentation of NSCLC using 3D-Slicer.

    PubMed

    Velazquez, Emmanuel Rios; Parmar, Chintan; Jermoumi, Mohammed; Mak, Raymond H; van Baardwijk, Angela; Fennessy, Fiona M; Lewis, John H; De Ruysscher, Dirk; Kikinis, Ron; Lambin, Philippe; Aerts, Hugo J W L

    2013-01-01

    Accurate volumetric assessment in non-small cell lung cancer (NSCLC) is critical for adequately informing treatments. In this study we assessed the clinical relevance of a semiautomatic computed tomography (CT)-based segmentation method using the competitive region-growing based algorithm, implemented in the free and public available 3D-Slicer software platform. We compared the 3D-Slicer segmented volumes by three independent observers, who segmented the primary tumour of 20 NSCLC patients twice, to manual slice-by-slice delineations of five physicians. Furthermore, we compared all tumour contours to the macroscopic diameter of the tumour in pathology, considered as the "gold standard". The 3D-Slicer segmented volumes demonstrated high agreement (overlap fractions > 0.90), lower volume variability (p = 0.0003) and smaller uncertainty areas (p = 0.0002), compared to manual slice-by-slice delineations. Furthermore, 3D-Slicer segmentations showed a strong correlation to pathology (r = 0.89, 95%CI, 0.81-0.94). Our results show that semiautomatic 3D-Slicer segmentations can be used for accurate contouring and are more stable than manual delineations. Therefore, 3D-Slicer can be employed as a starting point for treatment decisions or for high-throughput data mining research, such as Radiomics, where manual delineating often represent a time-consuming bottleneck. PMID:24346241

  13. Imaging of the pancreas: Recent advances

    PubMed Central

    Chaudhary, Vikas; Bano, Shahina

    2011-01-01

    A wide spectrum of anomalies of pancreas and the pancreatic duct system are commonly encountered at radiological evaluation. Diagnosing pancreatic lesions generally requires a multimodality approach. This review highlights the new advances in pancreatic imaging and their applications in the diagnosis and management of pancreatic pathologies. The mainstay techniques include computed tomography (CT), magnetic resonance imaging (MRI), endoscopic ultrasound (EUS), radionuclide imaging (RNI) and optical coherence tomography (OCT). PMID:21847450

  14. Advances in optical imaging for pharmacological studies

    PubMed Central

    Arranz, Alicia; Ripoll, Jorge

    2015-01-01

    Imaging approaches are an essential tool for following up over time representative parameters of in vivo models, providing useful information in pharmacological studies. Main advantages of optical imaging approaches compared to other imaging methods are their safety, straight-forward use and cost-effectiveness. A main drawback, however, is having to deal with the presence of high scattering and high absorption in living tissues. Depending on how these issues are addressed, three different modalities can be differentiated: planar imaging (including fluorescence and bioluminescence in vivo imaging), optical tomography, and optoacoustic approaches. In this review we describe the latest advances in optical in vivo imaging with pharmacological applications, with special focus on the development of new optical imaging probes in order to overcome the strong absorption introduced by different tissue components, especially hemoglobin, and the development of multimodal imaging systems in order to overcome the resolution limitations imposed by scattering. PMID:26441646

  15. Advanced noninvasive imaging of spinal vascular malformations

    PubMed Central

    Eddleman, Christopher S.; Jeong, Hyun; Cashen, Ty A.; Walker, Matthew; Bendok, Bernard R.; Batjer, H. Hunt; Carroll, Timothy J.

    2010-01-01

    Spinal vascular malformations (SVMs) are an uncommon, heterogeneous group of vascular anomalies that can render devastating neurological consequences if they are not diagnosed and treated in a timely fashion. Imaging SVMs has always presented a formidable challenge because their clinical and imaging presentations resemble those of neoplasms, demyelination diseases, and infection. Advancements in noninvasive imaging modalities (MR and CT angiography) have increased during the last decade and have improved the ability to accurately diagnose spinal vascular anomalies. In addition, intraoperative imaging techniques have been developed that aid in the intraoperative assessment before, during, and after resection of these lesions with minimal and/or optimal use of spinal digital subtraction angiography. In this report, the authors review recent advancements in the imaging of SVMs that will likely lead to more timely diagnoses and treatment while reducing procedural risk exposure to the patients who harbor these uncommon spinal lesions. PMID:19119895

  16. Chemical Approaches for Advanced Optical Imaging

    NASA Astrophysics Data System (ADS)

    Chen, Zhixing

    Advances in optical microscopy have been constantly expanding our knowledge of biological systems. The achievements therein are a result of close collaborations between physicists/engineers who build the imaging instruments and chemists/biochemists who design the corresponding probe molecules. In this work I present a number of chemical approaches for the development of advanced optical imaging methods. Chapter 1 provides an overview of the recent advances of novel imaging approaches taking advantage of chemical tag technologies. Chapter 2 describes the second-generation covalent trimethoprim-tag as a viable tool for live cell protein-specific labeling and imaging. In Chapter 3 we present a fluorescence lifetime imaging approach to map protein-specific micro-environment in live cells using TMP-Cy3 as a chemical probe. In Chapter 4, we present a method harnessing photo-activatable fluorophores to extend the fundamental depth limit in multi-photon microscopy. Chapter 5 describes the development of isotopically edited alkyne palette for multi-color live cell vibrational imaging of cellular small molecules. These studies exemplify the impact of modern chemical approaches in the development of advanced optical microscopies.

  17. Advanced Microwave/Millimeter-Wave Imaging Technology

    NASA Astrophysics Data System (ADS)

    Shen, Zuowei; Yang, Lu; Luhmann, N. C., Jr.; Domier, C. W.; Ito, N.; Kogi, Y.; Liang, Y.; Mase, A.; Park, H.; Sakata, E.; Tsai, W.; Xia, Z. G.; Zhang, P.

    Millimeter wave technology advances have made possible active and passive millimeter wave imaging for a variety of applications including advanced plasma diagnostics, radio astronomy, atmospheric radiometry, concealed weapon detection, all-weather aircraft landing, contraband goods detection, harbor navigation/surveillance in fog, highway traffic monitoring in fog, helicopter and automotive collision avoidance in fog, and environmental remote sensing data associated with weather, pollution, soil moisture, oil spill detection, and monitoring of forest fires, to name but a few. The primary focus of this paper is on technology advances which have made possible advanced imaging and visualization of magnetohydrodynamic (MHD) fluctuations and microturbulence in fusion plasmas. Topics of particular emphasis include frequency selective surfaces, planar Schottky diode mixer arrays, electronically controlled beam shaping/steering arrays, and high power millimeter wave local oscillator and probe sources.

  18. Advances in endoscopic imaging in ulcerative colitis.

    PubMed

    Tontini, Gian Eugenio; Pastorelli, Luca; Ishaq, Sauid; Neumann, Helmut

    2015-01-01

    Modern strategies for the treatment of ulcerative colitis require more accurate tools for gastrointestinal imaging to better assess mucosal disease activity and long-term prognostic clinical outcomes. Recent advances in gastrointestinal luminal endoscopy are radically changing the role of endoscopy in every-day clinical practice and research trials. Advanced endoscopic imaging techniques including high-definition endoscopes, optical magnification endoscopy, and various chromoendoscopy techniques have remarkably improved endoscopic assessment of ulcerative colitis. More recently, optical biopsy techniques with either endocytoscopy or confocal laser endomicroscopy have shown great potential in predicting several histological changes in real time during ongoing endoscopy. Here, we review current applications of advanced endoscopic imaging techniques in ulcerative colitis and present the most promising upcoming headways in this field. PMID:26365308

  19. Advances in electromagnetic brain imaging

    NASA Astrophysics Data System (ADS)

    Nagarajan, Srikantan S.

    2010-02-01

    Non-invasive and dynamic imaging of brain activity in the sub-millisecond time-scale is enabled by measurements on or near the scalp surface using an array of sensors that measure magnetic fields (magnetoencephalography (MEG)) or electric potentials (electroencephalography (EEG)). Algorithmic reconstruction of brain activity from MEG and EEG data is referred to as electromagnetic brain imaging (EBI). Reconstructing the actual brain response to external events and distinguishing unrelated brain activity has been a challenge for many existing algorithms in this field. Furthermore, even under conditions where there is very little interference, accurately determining the spatial locations and timing of brain sources from MEG and EEG data is challenging problem because it involves solving for unknown brain activity across thousands of voxels from just a few sensors (~300). In recent years, my research group has developed a suite of novel and powerful algorithms for EBI that we have shown to be considerably superior to existing benchmark algorithms. Specifically, these algorithms can solve for many brain sources, including sources located far from the sensors, in the presence of large interference from unrelated brain sources. Our algorithms efficiently model interference contributions to sensors, accurately estimate sparse brain source activity using fast and robust probabilistic inference techniques. Here, we review some of these algorithms and illustrate their performance in simulations and real MEG/EEG data.

  20. Personnel screening with advanced multistatic imaging technology

    NASA Astrophysics Data System (ADS)

    Ahmed, Sherif S.

    2013-05-01

    Personnel screening is demanded nowadays for securing air traffic as well as critical infrastructures. The millimeter-waves are able to penetrate clothes and detect concealed objects, making them an attractive choice for security screening. Imaging methods based on multistatic architecture can ensure high quality imagery in terms of resolution and dynamic range. Following the advances in semiconductor technology, fully electronic solutions delivering real-time imaging are becoming feasible. Furthermore, the continuously increasing capabilities of digital signal processing units allow for the utilization of digital-beamforming techniques for image reconstruction, thus offering new opportunities for imaging systems to use sophisticated operation modes. Based on these modern technologies, an advanced realization addressing personnel screening in E-band with planar multistatic sparse array design is demonstrated.

  1. Advances in Molecular Imaging with Ultrasound

    PubMed Central

    Gessner, Ryan; Dayton, Paul A.

    2010-01-01

    Ultrasound imaging has long demonstrated utility in the study and measurement of anatomic features and noninvasive observation of blood flow. Within the last decade, advances in molecular biology and contrast agents have allowed researchers to use ultrasound to detect changes in the expression of molecular markers on the vascular endothelium and other intravascular targets. This new technology, referred to as ultrasonic molecular imaging, is still in its infancy. However, in preclinical studies, ultrasonic molecular imaging has shown promise in assessing angiogenesis, inflammation, and thrombus. In this review, we discuss recent advances in microbubble-type contrast agent development, ultrasound technology, and signal processing strategies that have the potential to substantially improve the capabilities and utility of ultrasonic molecular imaging. PMID:20487678

  2. Development of a slicer integral field unit for the existing optical spectrograph FOCAS: progress

    NASA Astrophysics Data System (ADS)

    Ozaki, Shinobu; Tanaka, Yoko; Hattori, Takashi; Mitsui, Kenji; Fukushima, Mitsuhiro; Okada, Norio; Obuchi, Yoshiyuki; Tsuzuki, Toshihiro; Miyazaki, Satoshi; Yamashita, Takuya

    2014-07-01

    We are developing an integral field unit (IFU) with an image slicer for the existing optical spectrograph, Faint Object Camera And Spectrograph (FOCAS), on the Subaru Telescope. The slice width is 0.43 arcsec, the slice number is 23, and the field of view is 13.5 × 9.89 arcsec2. Sky spectrum separated by about 5.7 arcmin from an object field can be simultaneously obtained, which allows us precise background subtraction. Slice mirrors, pupil mirrors and slit mirrors are all glass, and their mirror surfaces are fabricated by polishing. Our IFU is about 200 mm × 300 mm × 80 mm in size and 1 kg in weight. It is installed into a mask storage in FOCAS along with one or two mask plates, and inserted into the optical path by using the existing mask exchange mechanism. This concept allow us flexible operation such as Targets of Opportunity observations. High reflectivity of multilayer dielectric coatings offers high throughput (>80%) of the IFU. In this paper, we will report a final optical layout, its performances, and results of prototyping works.

  3. AGO3 Slicer activity regulates mitochondria–nuage localization of Armitage and piRNA amplification

    PubMed Central

    Huang, Haidong; Li, Yujing; Szulwach, Keith E.; Zhang, Guoqiang

    2014-01-01

    In Drosophila melanogaster the reciprocal “Ping-Pong” cycle of PIWI-interacting RNA (piRNA)–directed RNA cleavage catalyzed by the endonuclease (or “Slicer”) activities of the PIWI proteins Aubergine (Aub) and Argonaute3 (AGO3) has been proposed to expand the secondary piRNA population. However, the role of AGO3/Aub Slicer activity in piRNA amplification remains to be explored. We show that AGO3 Slicer activity is essential for piRNA amplification and that AGO3 inhibits the homotypic Aub:Aub Ping-Pong process in a Slicer-independent manner. We also find that expression of an AGO3 Slicer mutant causes ectopic accumulation of Armitage, a key component in the primary piRNA pathway, in the Drosophila melanogaster germline granules known as nuage. AGO3 also coexists and interacts with Armitage in the mitochondrial fraction. Furthermore, AGO3 acts in conjunction with the mitochondria-associated protein Zucchini to control the dynamic subcellular localization of Armitage between mitochondria and nuage in a Slicer-dependent fashion. Collectively, our findings uncover a new mechanism that couples mitochondria with nuage to regulate secondary piRNA amplification. PMID:25049272

  4. Advanced endoscopic imaging to improve adenoma detection

    PubMed Central

    Neumann, Helmut; Nägel, Andreas; Buda, Andrea

    2015-01-01

    Advanced endoscopic imaging is revolutionizing our way on how to diagnose and treat colorectal lesions. Within recent years a variety of modern endoscopic imaging techniques was introduced to improve adenoma detection rates. Those include high-definition imaging, dye-less chromoendoscopy techniques and novel, highly flexible endoscopes, some of them equipped with balloons or multiple lenses in order to improve adenoma detection rates. In this review we will focus on the newest developments in the field of colonoscopic imaging to improve adenoma detection rates. Described techniques include high-definition imaging, optical chromoendoscopy techniques, virtual chromoendoscopy techniques, the Third Eye Retroscope and other retroviewing devices, the G-EYE endoscope and the Full Spectrum Endoscopy-system. PMID:25789092

  5. Advanced technologies for remote sensing imaging applications

    SciTech Connect

    Wood, L.L.

    1993-06-07

    Generating and returning imagery from great distances has been generally associated with national security activities, with emphasis on reliability of system operation. (While the introduction of such capabilities was usually characterized by high levels of innovation, the evolution of such systems has followed the classical track of proliferation of ``standardized items`` expressing ever more incremental technological advances.) Recent focusing of interest on the use of remote imaging systems for commercial and scientific purposes can be expected to induce comparatively rapid advances along the axes of efficiency and technological sophistication, respectively. This paper reviews the most basic reasons for expecting the next decade of advances to dwarf the impressive accomplishments of the past ten years. The impact of these advances clearly will be felt in all major areas of large-scale human endeavor, commercial, military and scientific.

  6. Advances in retinal ganglion cell imaging

    PubMed Central

    Balendra, S I; Normando, E M; Bloom, P A; Cordeiro, M F

    2015-01-01

    Glaucoma is one of the leading causes of blindness worldwide and will affect 79.6 million people worldwide by 2020. It is caused by the progressive loss of retinal ganglion cells (RGCs), predominantly via apoptosis, within the retinal nerve fibre layer and the corresponding loss of axons of the optic nerve head. One of its most devastating features is its late diagnosis and the resulting irreversible visual loss that is often predictable. Current diagnostic tools require significant RGC or functional visual field loss before the threshold for detection of glaucoma may be reached. To propel the efficacy of therapeutics in glaucoma, an earlier diagnostic tool is required. Recent advances in retinal imaging, including optical coherence tomography, confocal scanning laser ophthalmoscopy, and adaptive optics, have propelled both glaucoma research and clinical diagnostics and therapeutics. However, an ideal imaging technique to diagnose and monitor glaucoma would image RGCs non-invasively with high specificity and sensitivity in vivo. It may confirm the presence of healthy RGCs, such as in transgenic models or retrograde labelling, or detect subtle changes in the number of unhealthy or apoptotic RGCs, such as detection of apoptosing retinal cells (DARC). Although many of these advances have not yet been introduced to the clinical arena, their successes in animal studies are enthralling. This review will illustrate the challenges of imaging RGCs, the main retinal imaging modalities, the in vivo techniques to augment these as specific RGC-imaging tools and their potential for translation to the glaucoma clinic. PMID:26293138

  7. Advanced laser systems for photoacoustic imaging

    NASA Astrophysics Data System (ADS)

    Klosner, Marc; Sampathkumar, Ashwin; Chan, Gary; Wu, Chunbai; Gross, Daniel; Heller, Donald F.

    2015-03-01

    We describe the ongoing development of laser systems for advanced photoacoustic imaging (PAI). We discuss the characteristics of these laser systems and their particular benefits for soft tissue imaging and next-generation breast cancer diagnostics. We provide an overview of laser performance and compare this with other laser systems that have been used for early-stage development of PAI. These advanced systems feature higher pulse energy output at clinically relevant repetition rates, as well as a novel wavelength-cycling output pulse format. Wavelength cycling provides pulse sequences for which the output repeatedly alternates between two wavelengths that provide differential imaging. This capability improves co-registration of captured differential images. We present imaging results of phantoms obtained with a commercial ultrasound detector system and a wavelength-cycling laser source providing ~500 mJ/pulse at 755 and 797 nm, operating at 25 Hz. The results include photoacoustic images and corresponding pulse-echo data from a tissue mimicking phantom containing inclusions, simulating tumors in the breast. We discuss the application of these systems to the contrast-enhanced detection of various tissue types and tumors.

  8. Web-based volume slicer for 3D electron-microscopy data from EMDB.

    PubMed

    Salavert-Torres, José; Iudin, Andrii; Lagerstedt, Ingvar; Sanz-García, Eduardo; Kleywegt, Gerard J; Patwardhan, Ardan

    2016-05-01

    We describe the functionality and design of the Volume slicer - a web-based slice viewer for EMDB entries. This tool uniquely provides the facility to view slices from 3D EM reconstructions along the three orthogonal axes and to rapidly switch between them and navigate through the volume. We have employed multiple rounds of user-experience testing with members of the EM community to ensure that the interface is easy and intuitive to use and the information provided is relevant. The impetus to develop the Volume slicer has been calls from the EM community to provide web-based interactive visualisation of 2D slice data. This would be useful for quick initial checks of the quality of a reconstruction. Again in response to calls from the community, we plan to further develop the Volume slicer into a fully-fledged Volume browser that provides integrated visualisation of EMDB and PDB entries from the molecular to the cellular scale.

  9. Web-based volume slicer for 3D electron-microscopy data from EMDB.

    PubMed

    Salavert-Torres, José; Iudin, Andrii; Lagerstedt, Ingvar; Sanz-García, Eduardo; Kleywegt, Gerard J; Patwardhan, Ardan

    2016-05-01

    We describe the functionality and design of the Volume slicer - a web-based slice viewer for EMDB entries. This tool uniquely provides the facility to view slices from 3D EM reconstructions along the three orthogonal axes and to rapidly switch between them and navigate through the volume. We have employed multiple rounds of user-experience testing with members of the EM community to ensure that the interface is easy and intuitive to use and the information provided is relevant. The impetus to develop the Volume slicer has been calls from the EM community to provide web-based interactive visualisation of 2D slice data. This would be useful for quick initial checks of the quality of a reconstruction. Again in response to calls from the community, we plan to further develop the Volume slicer into a fully-fledged Volume browser that provides integrated visualisation of EMDB and PDB entries from the molecular to the cellular scale. PMID:26876163

  10. Foundations of Advanced Magnetic Resonance Imaging

    PubMed Central

    Bammer, Roland; Skare, Stefan; Newbould, Rexford; Liu, Chunlei; Thijs, Vincent; Ropele, Stefan; Clayton, David B.; Krueger, Gunnar; Moseley, Michael E.; Glover, Gary H.

    2005-01-01

    Summary: During the past decade, major breakthroughs in magnetic resonance imaging (MRI) quality were made by means of quantum leaps in scanner hardware and pulse sequences. Some advanced MRI techniques have truly revolutionized the detection of disease states and MRI can now—within a few minutes—acquire important quantitative information noninvasively from an individual in any plane or volume at comparatively high resolution. This article provides an overview of the most common advanced MRI methods including diffusion MRI, perfusion MRI, functional MRI, and the strengths and weaknesses of MRI at high magnetic field strengths. PMID:15897944

  11. Foundations of advanced magnetic resonance imaging.

    PubMed

    Bammer, Roland; Skare, Stefan; Newbould, Rexford; Liu, Chunlei; Thijs, Vincent; Ropele, Stefan; Clayton, David B; Krueger, Gunnar; Moseley, Michael E; Glover, Gary H

    2005-04-01

    During the past decade, major breakthroughs in magnetic resonance imaging (MRI) quality were made by means of quantum leaps in scanner hardware and pulse sequences. Some advanced MRI techniques have truly revolutionized the detection of disease states and MRI can now-within a few minutes-acquire important quantitative information noninvasively from an individual in any plane or volume at comparatively high resolution. This article provides an overview of the most common advanced MRI methods including diffusion MRI, perfusion MRI, functional MRI, and the strengths and weaknesses of MRI at high magnetic field strengths.

  12. Terahertz Tools Advance Imaging for Security, Industry

    NASA Technical Reports Server (NTRS)

    2010-01-01

    Picometrix, a wholly owned subsidiary of Advanced Photonix Inc. (API), of Ann Arbor, Michigan, invented the world s first commercial terahertz system. The company improved the portability and capabilities of their systems through Small Business Innovation Research (SBIR) agreements with Langley Research Center to provide terahertz imaging capabilities for inspecting the space shuttle external tanks and orbiters. Now API s systems make use of the unique imaging capacity of terahertz radiation on manufacturing floors, for thickness measurements of coatings, pharmaceutical tablet production, and even art conservation.

  13. Imaging Tumor Hypoxia to Advance Radiation Oncology

    PubMed Central

    Lee, Chen-Ting; Boss, Mary-Keara

    2014-01-01

    Abstract Significance: Most solid tumors contain regions of low oxygenation or hypoxia. Tumor hypoxia has been associated with a poor clinical outcome and plays a critical role in tumor radioresistance. Recent Advances: Two main types of hypoxia exist in the tumor microenvironment: chronic and cycling hypoxia. Chronic hypoxia results from the limited diffusion distance of oxygen, and cycling hypoxia primarily results from the variation in microvessel red blood cell flux and temporary disturbances in perfusion. Chronic hypoxia may cause either tumor progression or regressive effects depending on the tumor model. However, there is a general trend toward the development of a more aggressive phenotype after cycling hypoxia. With advanced hypoxia imaging techniques, spatiotemporal characteristics of tumor hypoxia and the changes to the tumor microenvironment can be analyzed. Critical Issues: In this review, we focus on the biological and clinical consequences of chronic and cycling hypoxia on radiation treatment. We also discuss the advanced non-invasive imaging techniques that have been developed to detect and monitor tumor hypoxia in preclinical and clinical studies. Future Directions: A better understanding of the mechanisms of tumor hypoxia with non-invasive imaging will provide a basis for improved radiation therapeutic practices. Antioxid. Redox Signal. 21, 313–337. PMID:24329000

  14. Image stabilization for SWIR advanced optoelectronic device

    NASA Astrophysics Data System (ADS)

    Schiopu, Paul; Manea, Adrian; Cristea, Ionica; Grosu, Neculai; Craciun, Anca-Ileana; Craciun, Alexandru; Granciu, Dana

    2015-02-01

    At long ranges and under low visibility conditions, Advanced Optoelectronic Device provides the signal-to-noise ratio and image quality in the Short-wave Infra-red - SWIR (wavelengths between 1,1 ÷2,5 μm), significantly better than in the near wave infrared - NWIR and visible spectral bands [1,2]. The quality of image is nearly independent of the polarization in the incoming light, but it is influenced by the relative movement between the optical system and the observer (the operators' handshake), and the movement towards the support system (land and air vehicles). All these make it difficult to detect objectives observation in real time. This paper presents some systems enhance which the ability of observation and sighting through the optical systems without the use of the stands, tripods or other means. We have to eliminate the effect of "tremors of the hands" and the vibration in order to allow the use of optical devices by operators on the moving vehicles on land, on aircraft, or on boats, and to provide additional comfort for the user to track the moving object through the optical system, without losing the control in the process of detection and tracking. The practical applications of stabilization image process, in SWIR, are the most advanced part of the optical observation systems available worldwide [3,4,5]. This application has a didactic nature, because it ensures understanding by the students about image stabilization and their participation in research.

  15. 3D Slicer as a Tool for Interactive Brain Tumor Segmentation

    PubMed Central

    Kikinis, Ron; Pieper, Steve

    2014-01-01

    User interaction is required for reliable segmentation of brain tumors in clinical practice and in clinical research. By incorporating current research tools, 3D Slicer provides a set of easy to use interactive tools that can be efficiently used for this purpose. PMID:22255945

  16. Recent advances in computer image generation simulation.

    PubMed

    Geltmacher, H E

    1988-11-01

    An explosion in flight simulator technology over the past 10 years is revolutionizing U.S. Air Force (USAF) operational training. The single, most important development has been in computer image generation. However, other significant advances are being made in simulator handling qualities, real-time computation systems, and electro-optical displays. These developments hold great promise for achieving high fidelity combat mission simulation. This article reviews the progress to date and predicts its impact, along with that of new computer science advances such as very high speed integrated circuits (VHSIC), on future USAF aircrew simulator training. Some exciting possibilities are multiship, full-mission simulators at replacement training units, miniaturized unit level mission rehearsal training simulators, onboard embedded training capability, and national scale simulator networking.

  17. Advances in computed tomography imaging technology.

    PubMed

    Ginat, Daniel Thomas; Gupta, Rajiv

    2014-07-11

    Computed tomography (CT) is an essential tool in diagnostic imaging for evaluating many clinical conditions. In recent years, there have been several notable advances in CT technology that already have had or are expected to have a significant clinical impact, including extreme multidetector CT, iterative reconstruction algorithms, dual-energy CT, cone-beam CT, portable CT, and phase-contrast CT. These techniques and their clinical applications are reviewed and illustrated in this article. In addition, emerging technologies that address deficiencies in these modalities are discussed.

  18. Advanced imaging of the scapholunate ligamentous complex.

    PubMed

    Shahabpour, Maryam; Staelens, Barbara; Van Overstraeten, Luc; De Maeseneer, Michel; Boulet, Cedric; De Mey, Johan; Scheerlinck, Thierry

    2015-12-01

    The scapholunate joint is one of the most involved in wrist injuries. Its stability depends on primary and secondary stabilisers forming together the scapholunate complex. This ligamentous complex is often evaluated by wrist arthroscopy. To avoid surgery as diagnostic procedure, optimization of MR imaging parameters as use of three-dimensional (3D) sequences with very thin slices and high spatial resolution, is needed to detect lesions of the intrinsic and extrinsic ligaments of the scapholunate complex. The paper reviews the literature on imaging of radial-sided carpal ligaments with advanced computed tomographic arthrography (CTA) and magnetic resonance arthrography (MRA) to evaluate the scapholunate complex. Anatomy and pathology of the ligamentous complex are described and illustrated with CTA, MRA and corresponding arthroscopy. Sprains, mid-substance tears, avulsions and fibrous infiltrations of carpal ligaments could be identified on CTA and MRA images using 3D fat-saturated PD and 3D DESS (dual echo with steady-state precession) sequences with 0.5-mm-thick slices. Imaging signs of scapholunate complex pathology include: discontinuity, nonvisualization, changes in signal intensity, contrast extravasation (MRA), contour irregularity and waviness and periligamentous infiltration by edema, granulation tissue or fibrosis. Based on this preliminary experience, we believe that 3 T MRA using 3D sequences with 0.5-mm-thick slices and multiplanar reconstructions is capable to evaluate the scapholunate complex and could help to reduce the number of diagnostic arthroscopies.

  19. Neurolight -astonishing advances in brain imaging.

    PubMed

    Rojczyk-Gołębiewska, Ewa; Pałasz, Artur; Worthington, John J; Markowski, Grzegorz; Wiaderkiewicz, Ryszard

    2015-02-01

    In recent years, significant advances in basic neuroanatomical studies have taken place. Moreover, such classical, clinically-oriented human brain imaging methods such as MRI, PET and DTI have been applied to small laboratory animals allowing improvement in current experimental neuroscience. Contemporary structural neurobiology also uses various technologies based on fluorescent proteins. One of these is optogenetics, which integrates physics, genetics and bioengineering to enable temporal precise control of electrical activity of specific neurons. Another important challenge in the field is the accurate imaging of complicated neural networks. To address this problem, three-dimensional reconstruction techniques and retrograde labeling with modified viruses has been developed. However, a revolutionary step was the invention of the "Brainbow" system, utilizing gene constructs including the sequences of fluorescent proteins and the usage of Cre recombinase to create dozens of colour combinations, enabling visualization of neurons and their connections in extremely high resolution. Furthermore, the newly- introduced CLARITY method should make it possible to visualize three-dimensionally the structure of translucent brain tissue using the hydrogel polymeric network. This original technique is a big advance in neuroscience creating novel viewpoints completely different than standard glass slide immunostaining. PMID:24730999

  20. Neurolight -astonishing advances in brain imaging.

    PubMed

    Rojczyk-Gołębiewska, Ewa; Pałasz, Artur; Worthington, John J; Markowski, Grzegorz; Wiaderkiewicz, Ryszard

    2015-02-01

    In recent years, significant advances in basic neuroanatomical studies have taken place. Moreover, such classical, clinically-oriented human brain imaging methods such as MRI, PET and DTI have been applied to small laboratory animals allowing improvement in current experimental neuroscience. Contemporary structural neurobiology also uses various technologies based on fluorescent proteins. One of these is optogenetics, which integrates physics, genetics and bioengineering to enable temporal precise control of electrical activity of specific neurons. Another important challenge in the field is the accurate imaging of complicated neural networks. To address this problem, three-dimensional reconstruction techniques and retrograde labeling with modified viruses has been developed. However, a revolutionary step was the invention of the "Brainbow" system, utilizing gene constructs including the sequences of fluorescent proteins and the usage of Cre recombinase to create dozens of colour combinations, enabling visualization of neurons and their connections in extremely high resolution. Furthermore, the newly- introduced CLARITY method should make it possible to visualize three-dimensionally the structure of translucent brain tissue using the hydrogel polymeric network. This original technique is a big advance in neuroscience creating novel viewpoints completely different than standard glass slide immunostaining.

  1. Recent advances in imaging subcellular processes

    PubMed Central

    Myers, Kenneth A.; Janetopoulos, Christopher

    2016-01-01

    Cell biology came about with the ability to first visualize cells. As microscopy techniques advanced, the early microscopists became the first cell biologists to observe the inner workings and subcellular structures that control life. This ability to see organelles within a cell provided scientists with the first understanding of how cells function. The visualization of the dynamic architecture of subcellular structures now often drives questions as researchers seek to understand the intricacies of the cell. With the advent of fluorescent labeling techniques, better and new optical techniques, and more sensitive and faster cameras, a whole array of questions can now be asked. There has been an explosion of new light microscopic techniques, and the race is on to build better and more powerful imaging systems so that we can further our understanding of the spatial and temporal mechanisms controlling molecular cell biology. PMID:27408708

  2. Recent advances in imaging subcellular processes.

    PubMed

    Myers, Kenneth A; Janetopoulos, Christopher

    2016-01-01

    Cell biology came about with the ability to first visualize cells. As microscopy techniques advanced, the early microscopists became the first cell biologists to observe the inner workings and subcellular structures that control life. This ability to see organelles within a cell provided scientists with the first understanding of how cells function. The visualization of the dynamic architecture of subcellular structures now often drives questions as researchers seek to understand the intricacies of the cell. With the advent of fluorescent labeling techniques, better and new optical techniques, and more sensitive and faster cameras, a whole array of questions can now be asked. There has been an explosion of new light microscopic techniques, and the race is on to build better and more powerful imaging systems so that we can further our understanding of the spatial and temporal mechanisms controlling molecular cell biology. PMID:27408708

  3. Hyperspectral image projector for advanced sensor characterization

    NASA Astrophysics Data System (ADS)

    Brown, S. W.; Rice, J. P.; Neira, J. E.; Bousquet, R.; Johnson, B. C.

    2006-08-01

    In this work, we describe radiometric platforms able to produce realistic spectral distributions and spatial scenes for the development of application-specific metrics to quantify the performance of sensors and systems. Using these platforms, sensor and system performance may be quantified in terms of the accuracy of measurements of standardized sets of complex source distributions. The same platforms can also serve as a basis for algorithm testing and instrument comparison. The platforms consist of spectrally tunable light sources (STS's) coupled with spatially programmable projection systems. The resultant hyperspectral image projectors (HIP) can generate complex spectral distributions with high spectral fidelity; that is, scenes with realistic spectral content. Using the same fundamental technology, platforms can be developed for the ultraviolet, visible, and infrared regions. These radiometric platforms will facilitate advanced sensor characterization testing, enabling a pre-flight validation of the pre-flight calibration.

  4. Advances in fluorescence labeling strategies for dynamic cellular imaging

    PubMed Central

    Dean, Kevin M; Palmer, Amy E

    2014-01-01

    Synergistic advances in optical physics, probe design, molecular biology, labeling techniques and computational analysis have propelled fluorescence imaging into new realms of spatiotemporal resolution and sensitivity. This review aims to discuss advances in fluorescent probes and live-cell labeling strategies, two areas that remain pivotal for future advances in imaging technology. Fluorescent protein– and bio-orthogonal–based methods for protein and RNA imaging are discussed as well as emerging bioengineering techniques that enable their expression at specific genomic loci (for example, CRISPR and TALENs). Important attributes that contribute to the success of each technique are emphasized, providing a guideline for future advances in dynamic live-cell imaging. PMID:24937069

  5. Web-based volume slicer for 3D electron-microscopy data from EMDB

    PubMed Central

    Salavert-Torres, José; Iudin, Andrii; Lagerstedt, Ingvar; Sanz-García, Eduardo; Kleywegt, Gerard J.; Patwardhan, Ardan

    2016-01-01

    We describe the functionality and design of the Volume slicer – a web-based slice viewer for EMDB entries. This tool uniquely provides the facility to view slices from 3D EM reconstructions along the three orthogonal axes and to rapidly switch between them and navigate through the volume. We have employed multiple rounds of user-experience testing with members of the EM community to ensure that the interface is easy and intuitive to use and the information provided is relevant. The impetus to develop the Volume slicer has been calls from the EM community to provide web-based interactive visualisation of 2D slice data. This would be useful for quick initial checks of the quality of a reconstruction. Again in response to calls from the community, we plan to further develop the Volume slicer into a fully-fledged Volume browser that provides integrated visualisation of EMDB and PDB entries from the molecular to the cellular scale. PMID:26876163

  6. Three-dimensional Printing and 3D Slicer: Powerful Tools in Understanding and Treating Structural Lung Disease.

    PubMed

    Cheng, George Z; San Jose Estepar, Raul; Folch, Erik; Onieva, Jorge; Gangadharan, Sidhu; Majid, Adnan

    2016-05-01

    Recent advances in the three-dimensional (3D) printing industry have enabled clinicians to explore the use of 3D printing in preprocedural planning, biomedical tissue modeling, and direct implantable device manufacturing. Despite the increased adoption of rapid prototyping and additive manufacturing techniques in the health-care field, many physicians lack the technical skill set to use this exciting and useful technology. Additionally, the growth in the 3D printing sector brings an ever-increasing number of 3D printers and printable materials. Therefore, it is important for clinicians to keep abreast of this rapidly developing field in order to benefit. In this Ahead of the Curve, we review the history of 3D printing from its inception to the most recent biomedical applications. Additionally, we will address some of the major barriers to wider adoption of the technology in the medical field. Finally, we will provide an initial guide to 3D modeling and printing by demonstrating how to design a personalized airway prosthesis via 3D Slicer. We hope this information will reduce the barriers to use and increase clinician participation in the 3D printing health-care sector.

  7. Three-dimensional Printing and 3D Slicer: Powerful Tools in Understanding and Treating Structural Lung Disease.

    PubMed

    Cheng, George Z; San Jose Estepar, Raul; Folch, Erik; Onieva, Jorge; Gangadharan, Sidhu; Majid, Adnan

    2016-05-01

    Recent advances in the three-dimensional (3D) printing industry have enabled clinicians to explore the use of 3D printing in preprocedural planning, biomedical tissue modeling, and direct implantable device manufacturing. Despite the increased adoption of rapid prototyping and additive manufacturing techniques in the health-care field, many physicians lack the technical skill set to use this exciting and useful technology. Additionally, the growth in the 3D printing sector brings an ever-increasing number of 3D printers and printable materials. Therefore, it is important for clinicians to keep abreast of this rapidly developing field in order to benefit. In this Ahead of the Curve, we review the history of 3D printing from its inception to the most recent biomedical applications. Additionally, we will address some of the major barriers to wider adoption of the technology in the medical field. Finally, we will provide an initial guide to 3D modeling and printing by demonstrating how to design a personalized airway prosthesis via 3D Slicer. We hope this information will reduce the barriers to use and increase clinician participation in the 3D printing health-care sector. PMID:26976347

  8. mRNA Decay of Most Arabidopsis miRNA Targets Requires Slicer Activity of AGO11[OPEN

    PubMed Central

    2016-01-01

    MicroRNAs (miRNAs) are key posttranscriptional regulators of gene expression in animals and plants. They guide RNA-induced silencing complexes to complementary target mRNA, thereby mediating mRNA degradation or translational repression. ARGONAUTE (AGO) proteins bind directly to miRNAs and may catalyze cleavage (slicing) of target mRNAs. In animals, miRNA target degradation via slicing occurs only exceptionally, and target mRNA decay is induced via AGO-dependent recruitment of deadenylase complexes. Conversely, plant miRNAs generally direct slicing of their targets, but it is unclear whether slicer-independent mechanisms of target mRNA decay also exist, and, if so, how much they contribute to miRNA-induced mRNA decay. Here, we compare phenotypes and transcript profiles of ago1 null and slicer-deficient mutants in Arabidopsis (Arabidopsis thaliana). We also construct conditional loss-of-function mutants of AGO1 to allow transcript profiling in true leaves. Although phenotypic differences between ago1 null and slicer-deficient mutants can be discerned, the results of both transcript profiling approaches indicate that slicer activity is required for mRNA repression of the vast majority of miRNA targets. A set of genes exhibiting up-regulation specifically in ago1 null, but not in ago1 slicer-deficient mutants was also identified, leaving open the possibility that AGO1 may have functions in gene regulation independent of small RNAs. PMID:27208258

  9. Advance of Molecular Imaging Technology and Targeted Imaging Agent in Imaging and Therapy

    PubMed Central

    Chen, Zhi-Yi; Wang, Yi-Xiang; Lin, Yan; Zhang, Jin-Shan; Yang, Feng; Zhou, Qiu-Lan; Liao, Yang-Ying

    2014-01-01

    Molecular imaging is an emerging field that integrates advanced imaging technology with cellular and molecular biology. It can realize noninvasive and real time visualization, measurement of physiological or pathological process in the living organism at the cellular and molecular level, providing an effective method of information acquiring for diagnosis, therapy, and drug development and evaluating treatment of efficacy. Molecular imaging requires high resolution and high sensitive instruments and specific imaging agents that link the imaging signal with molecular event. Recently, the application of new emerging chemical technology and nanotechnology has stimulated the development of imaging agents. Nanoparticles modified with small molecule, peptide, antibody, and aptamer have been extensively applied for preclinical studies. Therapeutic drug or gene is incorporated into nanoparticles to construct multifunctional imaging agents which allow for theranostic applications. In this review, we will discuss the characteristics of molecular imaging, the novel imaging agent including targeted imaging agent and multifunctional imaging agent, as well as cite some examples of their application in molecular imaging and therapy. PMID:24689058

  10. Beyond whole-body imaging: advanced imaging techniques of PET/MRI.

    PubMed

    Barnwell, James; Raptis, Constantine A; McConathy, Jonathan E; Laforest, Richard; Siegel, Barry A; Woodard, Pamela K; Fowler, Kathryn

    2015-02-01

    PET/MRI is a hybrid imaging modality that is gaining clinical interest with the first Food and Drug Administration-approved simultaneous imaging system recently added to the clinical armamentarium. Several advanced PET/MRI applications, such as high-resolution anatomic imaging, diffusion-weighted imaging, motion correction, and cardiac imaging, show great potential for clinical use. The purpose of this article is to highlight several advanced PET/MRI applications through case examples and review of the current literature.

  11. Tuberculosis, advanced - chest x-rays (image)

    MedlinePlus

    ... tissue, and can cause tissue death. These chest x-rays show advanced pulmonary tuberculosis. There are multiple light ... location of cavities within these light areas. The x-ray on the left clearly shows that the opacities ...

  12. Advanced Imaging Optics Utilizing Wavefront Coding.

    SciTech Connect

    Scrymgeour, David; Boye, Robert; Adelsberger, Kathleen

    2015-06-01

    Image processing offers a potential to simplify an optical system by shifting some of the imaging burden from lenses to the more cost effective electronics. Wavefront coding using a cubic phase plate combined with image processing can extend the system's depth of focus, reducing many of the focus-related aberrations as well as material related chromatic aberrations. However, the optimal design process and physical limitations of wavefront coding systems with respect to first-order optical parameters and noise are not well documented. We examined image quality of simulated and experimental wavefront coded images before and after reconstruction in the presence of noise. Challenges in the implementation of cubic phase in an optical system are discussed. In particular, we found that limitations must be placed on system noise, aperture, field of view and bandwidth to develop a robust wavefront coded system.

  13. Advanced ultrasound probes for medical imaging

    NASA Astrophysics Data System (ADS)

    Wildes, Douglas G.; Smith, L. Scott

    2012-05-01

    New medical ultrasound probe architectures and materials build upon established 1D phased array technology and provide improved imaging performance and clinical value. Technologies reviewed include 1.25D and 1.5D arrays for elevation slice thickness control; electro-mechanical and 2D array probes for real-time 3D imaging; catheter probes for imaging during minimally-invasive procedures; single-crystal piezoelectric materials for greater frequency bandwidth; and cMUT arrays using silicon MEMS in place of piezo materials.

  14. Advances in Small Animal Imaging Systems

    NASA Astrophysics Data System (ADS)

    Loudos, George K.

    2007-11-01

    The rapid growth in genetics and molecular biology combined with the development of techniques for genetically engineering small animals has led to an increased interest in in vivo laboratory animal imaging during the past few years. For this purpose, new instrumentation, data acquisition strategies, and image processing and reconstruction techniques are being developed, researched and evaluated. The aim of this article is to give a short overview of the state of the art technologies for high resolution and high sensitivity molecular imaging techniques, primarily positron emission tomography (PET) and single photon emission computed tomography (SPECT). The basic needs of small animal imaging will be described. The evolution in instrumentation in the past two decades, as well as the commercially available systems will be overviewed. Finally, the new trends in detector technology and preliminary results from challenging applications will be presented. For more details a number of references are provided.

  15. Advanced Image Search: A Strategy for Creating Presentation Boards

    ERIC Educational Resources Information Center

    Frey, Diane K.; Hines, Jean D.; Swinker, Mary E.

    2008-01-01

    Finding relevant digital images to create presentation boards requires advanced search skills. This article describes a course assignment involving a technique designed to develop students' literacy skills with respect to locating images of desired quality and content from Internet databases. The assignment was applied in a collegiate apparel…

  16. Clinical Application and Research Advances of CT Myocardial Perfusion Imaging.

    PubMed

    2016-06-10

    Computed tomography (CT)-based myocardial perfusion imaging (CTP)has been widely recognized as a one-station solution for the imaging of myocardial ischemia-related diseases. This article reviews the clinical scanning protocols,analytical methods,and research advances of CTP in recent years and briefly discusses its limitations and future development. PMID:27469926

  17. Advanced automated char image analysis techniques

    SciTech Connect

    Tao Wu; Edward Lester; Michael Cloke

    2006-05-15

    Char morphology is an important characteristic when attempting to understand coal behavior and coal burnout. In this study, an augmented algorithm has been proposed to identify char types using image analysis. On the basis of a series of image processing steps, a char image is singled out from the whole image, which then allows the important major features of the char particle to be measured, including size, porosity, and wall thickness. The techniques for automated char image analysis have been tested against char images taken from ICCP Char Atlas as well as actual char particles derived from pyrolyzed char samples. Thirty different chars were prepared in a drop tube furnace operating at 1300{sup o}C, 1% oxygen, and 100 ms from 15 different world coals sieved into two size fractions (53-75 and 106-125 {mu}m). The results from this automated technique are comparable with those from manual analysis, and the additional detail from the automated sytem has potential use in applications such as combustion modeling systems. Obtaining highly detailed char information with automated methods has traditionally been hampered by the difficulty of automatic recognition of individual char particles. 20 refs., 10 figs., 3 tabs.

  18. Center for Advanced Signal and Imaging Sciences Workshop 2004

    SciTech Connect

    McClellan, J H; Carrano, C; Poyneer, L; Palmer, D; Baker, K; Chen, D; London, R; Weinert, G; Brase, J; Paglieroni, D; Lopez, A; Grant, C W; Wright, W; Burke, M; Miller, W O; DeTeresa, S; White, D; Toeppen, J; Haugen, P; Kamath, C; Nguyen, T; Manay, S; Newsam, S; Cantu-Paz, E; Pao, H; Chang, J; Chambers, D; Leach, R; Paulson, C; Romero, C E; Spiridon, A; Vigars, M; Welsh, P; Zumstein, J; Romero, K; Oppenheim, A; Harris, D B; Dowla, F; Brown, C G; Clark, G A; Ong, M M; Clance, T J; Kegelmeyer, l M; Benzuijen, M; Bliss, E; Burkhart, S; Conder, A; Daveler, S; Ferguson, W; Glenn, S; Liebman, J; Norton, M; Prasad, R; Salmon, T; Kegelmeyer, L M; Hafiz, O; Cheung, S; Fodor, I; Aufderheide, M B; Bary, A; Martz, Jr., H E; Burke, M W; Benson, S; Fisher, K A; Quarry, M J

    2004-11-15

    Welcome to the Eleventh Annual C.A.S.I.S. Workshop, a yearly event at the Lawrence Livermore National Laboratory, presented by the Center for Advanced Signal & Image Sciences, or CASIS, and sponsored by the LLNL Engineering Directorate. Every November for the last 10 years we have convened a diverse set of engineering and scientific talent to share their work in signal processing, imaging, communications, controls, along with associated fields of mathematics, statistics, and computing sciences. This year is no exception, with sessions in Adaptive Optics, Applied Imaging, Scientific Data Mining, Electromagnetic Image and Signal Processing, Applied Signal Processing, National Ignition Facility (NIF) Imaging, and Nondestructive Characterization.

  19. Advances in Optical Spectroscopy and Imaging of Breast Lesions

    SciTech Connect

    Demos, S; Vogel, A J; Gandjbakhche, A H

    2006-01-03

    A review is presented of recent advances in optical imaging and spectroscopy and the use of light for addressing breast cancer issues. Spectroscopic techniques offer the means to characterize tissue components and obtain functional information in real time. Three-dimensional optical imaging of the breast using various illumination and signal collection schemes in combination with image reconstruction algorithms may provide a new tool for cancer detection and monitoring of treatment.

  20. Imaging morphogenesis: technological advances and biological insights.

    PubMed

    Keller, Philipp J

    2013-06-01

    Morphogenesis, the development of the shape of an organism, is a dynamic process on a multitude of scales, from fast subcellular rearrangements and cell movements to slow structural changes at the whole-organism level. Live-imaging approaches based on light microscopy reveal the intricate dynamics of this process and are thus indispensable for investigating the underlying mechanisms. This Review discusses emerging imaging techniques that can record morphogenesis at temporal scales from seconds to days and at spatial scales from hundreds of nanometers to several millimeters. To unlock their full potential, these methods need to be matched with new computational approaches and physical models that help convert highly complex image data sets into biological insights.

  1. Advanced enhancement techniques for digitized images

    NASA Astrophysics Data System (ADS)

    Tom, V. T.; Merenyi, R. C.; Carlotto, M. J.; Heller, W. G.

    Computer image enhancement of digitized X-ray and conventional photographs has been employed to reveal anomalies in aerospace hardware. Signal processing of these images included use of specially-developed filters to sharpen detail without sacrificing radiographic information, application of local contrast stretch and histogram equalization algorithms to display structure in low-contrast areas and employment of other unique digital processing methods. Edge detection, normally complicated by poor spatial resolution, limited contrast and recording media noise, was performed as a post-processing operation via a difference-of-Gaussians method and a least squares fitting procedures. In this manner, multi-image signal processing allowed for the precise measurement (to within 0.02 inches, rms) of the Inertial Upper Stage nozzle nosecap motion during a static test firing as well as identifying potential problems in the Solid Rocket Booster parachute deployment.

  2. Advances in noninvasive imaging of melanoma.

    PubMed

    Menge, Tyler D; Pellacani, Giovanni

    2016-03-01

    Melanoma is the most dangerous type of skin cancer and its incidence has risen sharply in recent decades. Early detection of disease is critical for improving patient outcomes. Any pigmented lesion that is clinically concerning must be removed by biopsy for morphologic investigation on histology. However, biopsies are invasive and can cause significant morbidity, and their accuracy in detecting melanoma may be limited by sampling error. The advent of noninvasive imaging devices has allowed for assessment of intact skin, thereby minimizing the need for biopsy; and these technologies are increasingly being used in the diagnosis and management of melanoma. Reflectance confocal microscopy, optical coherence tomography, ultrasonography, and multispectral imaging are noninvasive imaging techniques that have emerged as diagnostic aids to physical exam and/or conventional dermoscopy. This review summarizes the current knowledge about these techniques and discusses their practical applications and limitations. PMID:26963113

  3. Advanced imaging of osseous maxillary clefts.

    PubMed

    Boyne, P J; Christiansen, E L; Thompson, J R

    1993-01-01

    A computed tomographic (CT) technique to establish precise two-dimensional (2-D) and three-dimensional (3-D) images of the osseous defects of cleft palates is presented and illustrated by two case studies. Prospective soft tissue algorithms and bone detail imaging was made possible by a retrospective program, a specific software program and vertical reformatting technique leading to 3-D image reconstruction. The two cases illustrate the flexibility of the CT program in accurately providing morphometric and bone density data on the location and size of the osseous defects involved in the cleft. Not every cleft palate patient is a candidate for the procedures outlined; however, the diagnosis of and treatment planning for patients presenting with bilateral or extensive osseous clefting can be more accurate.

  4. Advanced optical imaging techniques for neurodevelopment.

    PubMed

    Wu, Yicong; Christensen, Ryan; Colón-Ramos, Daniel; Shroff, Hari

    2013-12-01

    Over the past decade, developmental neuroscience has been transformed by the widespread application of confocal and two-photon fluorescence microscopy. Even greater progress is imminent, as recent innovations in microscopy now enable imaging with increased depth, speed, and spatial resolution; reduced phototoxicity; and in some cases without external fluorescent probes. We discuss these new techniques and emphasize their dramatic impact on neurobiology, including the ability to image neurons at depths exceeding 1mm, to observe neurodevelopment noninvasively throughout embryogenesis, and to visualize neuronal processes or structures that were previously too small or too difficult to target with conventional microscopy.

  5. Advanced Optical Imaging Techniques for Neurodevelopment

    PubMed Central

    Wu, Yicong; Christensen, Ryan; Colón-Ramos, Daniel; Shroff, Hari

    2013-01-01

    Over the past decade, developmental neuroscience has been transformed by the widespread application of confocal and two-photon fluorescence microscopy. Even greater progress is imminent, as recent innovations in microscopy now enable imaging with increased depth, speed, and spatial resolution; reduced phototoxicity; and in some cases without external fluorescent probes. We discuss these new techniques and emphasize their dramatic impact on neurobiology, including the ability to image neurons at depths exceeding 1 mm, to observe neurodevelopment noninvasively throughout embryogenesis, and to visualize neuronal processes or structures that were previously too small or too difficult to target with conventional microscopy. PMID:23831260

  6. Advances in Pediatric Small Bowel Imaging.

    PubMed

    Lin, Tom K

    2016-01-01

    Technological advances for visualizing the small bowel have significantly grown over the past few decades. Balloon-assisted enteroscopy has come to the forefront of these innovations, and has been found to be safe and effective in children with small bowel ailments. The expanding body of research into balloon-assisted enteroscopy will continue to refine the current knowledge base of this technique, along with a growing assessment of the long-term benefits of such interventions. PMID:26616902

  7. Recent advances in breast cancer imaging.

    PubMed

    Newman, J

    1999-01-01

    Mammography is the best technique currently available for early detection of breast cancer, but it has limitations. Several new techniques are under investigation that may provide valuable complementary images. This article discusses some of the most promising adjuncts to film-screen mammography, including digital mammography, ultrasound of the breast, breast MR, scintimammography and sentinel node lymphoscintigraphy.

  8. Advances in Lymphatic Imaging and Drug Delivery

    SciTech Connect

    Nune, Satish K.; Gunda, Padmaja; Majeti, Bharat K.; Thallapally, Praveen K.; Laird, Forrest M.

    2011-09-10

    Cancer remains the second leading cause of death after heart disease in the US. While metastasized cancers such as breast, prostate, and colon are incurable, before their distant spread, these diseases will have invaded the lymphatic system as a first step in their progression. Hence, proper evaluation of the disease state of the lymphatics which drain a tumor site is crucial to staging and the formation of a treatment plan. Current lymphatic imaging modalities with visible dyes and radionucleotide tracers offer limited sensitivity and poor resolution; however, newer tools using nanocarriers, quantum dots, and magnetic resonance imaging promise to vastly improve the staging of lymphatic spread without needless biopsies. Concurrent with the improvement of lymphatic imaging agents, has been the development of drug carriers that can localize chemotherapy to the lymphatic system, thus improving the treatment of localized disease while minimizing the exposure of healthy organs to cytotoxic drugs. This review will focus on polymeric systems that have been developed for imaging and drug delivery to the lymph system, how these new devices improve upon current technologies, and where further improvement is needed.

  9. Multispectral laser imaging for advanced food analysis

    NASA Astrophysics Data System (ADS)

    Senni, L.; Burrascano, P.; Ricci, M.

    2016-07-01

    A hardware-software apparatus for food inspection capable of realizing multispectral NIR laser imaging at four different wavelengths is herein discussed. The system was designed to operate in a through-transmission configuration to detect the presence of unwanted foreign bodies inside samples, whether packed or unpacked. A modified Lock-In technique was employed to counterbalance the significant signal intensity attenuation due to transmission across the sample and to extract the multispectral information more efficiently. The NIR laser wavelengths used to acquire the multispectral images can be varied to deal with different materials and to focus on specific aspects. In the present work the wavelengths were selected after a preliminary analysis to enhance the image contrast between foreign bodies and food in the sample, thus identifying the location and nature of the defects. Experimental results obtained from several specimens, with and without packaging, are presented and the multispectral image processing as well as the achievable spatial resolution of the system are discussed.

  10. Advanced image analysis for the preservation of cultural heritage

    NASA Astrophysics Data System (ADS)

    France, Fenella G.; Christens-Barry, William; Toth, Michael B.; Boydston, Kenneth

    2010-02-01

    The Library of Congress' Preservation Research and Testing Division has established an advanced preservation studies scientific program for research and analysis of the diverse range of cultural heritage objects in its collection. Using this system, the Library is currently developing specialized integrated research methodologies for extending preservation analytical capacities through non-destructive hyperspectral imaging of cultural objects. The research program has revealed key information to support preservation specialists, scholars and other institutions. The approach requires close and ongoing collaboration between a range of scientific and cultural heritage personnel - imaging and preservation scientists, art historians, curators, conservators and technology analysts. A research project of the Pierre L'Enfant Plan of Washington DC, 1791 had been undertaken to implement and advance the image analysis capabilities of the imaging system. Innovative imaging options and analysis techniques allow greater processing and analysis capacities to establish the imaging technique as the first initial non-invasive analysis and documentation step in all cultural heritage analyses. Mapping spectral responses, organic and inorganic data, topography semi-microscopic imaging, and creating full spectrum images have greatly extended this capacity from a simple image capture technique. Linking hyperspectral data with other non-destructive analyses has further enhanced the research potential of this image analysis technique.

  11. Conventional and advanced imaging in neuromyelitis optica.

    PubMed

    Barnett, Y; Sutton, I J; Ghadiri, M; Masters, L; Zivadinov, R; Barnett, M H

    2014-08-01

    Myelitis and optic neuritis are prototypic clinical presentations of both multiple sclerosis and neuromyelitis optica. Once considered a subtype of multiple sclerosis, neuromyelitis optica, is now known to have a discrete pathogenesis in which antibodies to the water channel, aquaporin 4, play a critical role. Timely differentiation of neuromyelitis optica from MS is imperative, determining both prognosis and treatment strategy. Early, aggressive immunosuppression is required to prevent the accrual of severe disability in neuromyelitis optica; conversely, MS-specific therapies may exacerbate the disease. The diagnosis of neuromyelitis optica requires the integration of clinical, MR imaging, and laboratory data, but current criteria are insensitive and exclude patients with limited clinical syndromes. Failure to recognize the expanding spectrum of cerebral MR imaging patterns associated with aquaporin 4 antibody seropositivity adds to diagnostic uncertainty in some patients. We present the state of the art in conventional and nonconventional MR imaging in neuromyelitis optica and review the place of neuroimaging in the diagnosis, management, and research of the condition.

  12. Recent advances in echocardiography: strain and strain rate imaging

    PubMed Central

    Mirea, Oana; Duchenne, Jurgen; Voigt, Jens-Uwe

    2016-01-01

    Deformation imaging by echocardiography is a well-established research tool which has been gaining interest from clinical cardiologists since the introduction of speckle tracking. Post-processing of echo images to analyze deformation has become readily available at the fingertips of the user. New parameters such as global longitudinal strain have been shown to provide added diagnostic value, and ongoing efforts of the imaging societies and industry aimed at harmonizing methods will improve the technique further. This review focuses on recent advances in the field of echocardiographic strain and strain rate imaging, and provides an overview on its current and potential future clinical applications. PMID:27158476

  13. Advanced Breast Imaging Availability by Screening Facility Characteristics

    PubMed Central

    Lee, Christoph I.; Bogart, Andy; Hubbard, Rebecca A.; Obadina, Eniola T.; Hill, Deirdre A.; Haas, Jennifer S.; Tosteson, Anna N.A.; Alford-Teaster, Jennifer A.; Sprague, Brian L.; DeMartini, Wendy B.; Lehman, Constance D.; Onega, Tracy L.

    2015-01-01

    Rationale and Objective To determine the relationship between screening mammography facility characteristics and on-site availability of advanced breast imaging services required for supplemental screening and the diagnostic evaluation of abnormal screening findings. Materials and Methods We analyzed data from all active imaging facilities across six regional registries of the National Cancer Institute-funded Breast Cancer Surveillance Consortium offering screening mammography in calendar years 2011–2012 (n=105). We used generalized estimating equations regression models to identify associations between facility characteristics (e.g., academic affiliation, practice type) and availability of on-site advanced breast imaging (e.g., ultrasound, magnetic resonance imaging (MRI)) and image-guided biopsy services. Results Breast MRI was not available at any non-radiology or breast imaging only facilities. A combination of breast US, breast MRI, and imaging-guided breast biopsy services was available at 76.0% of multi-specialty breast centers compared to 22.2% of full diagnostic radiology practices (p=0.0047) and 75.0% of facilities with academic affiliations compared to 29.0% of those without academic affiliations (p=0.04). Both supplemental screening breast ultrasound and screening breast MRI were available at 28.0% of multi-specialty breast centers compared to 4.7% of full diagnostic radiology practices (p<0.01) and 25.0% of academic facilities compared to 8.5% of non-academic facilities (p=0.02). Conclusion Screening facility characteristics are strongly associated with the availability of on-site advanced breast imaging and image-guided biopsy service. Therefore, the type of imaging facility a woman attends for screening may have important implications on her timely access to supplemental screening and diagnostic breast imaging services. PMID:25851643

  14. Advanced and Conventional Magnetic Resonance Imaging in Neuropsychiatric Lupus.

    PubMed

    Sarbu, Nicolae; Bargalló, Núria; Cervera, Ricard

    2015-01-01

    Neuropsychiatric lupus is a major diagnostic challenge, and a main cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Magnetic resonance imaging (MRI) is, by far, the main tool for assessing the brain in this disease. Conventional and advanced MRI techniques are used to help establishing the diagnosis, to rule out alternative diagnoses, and recently, to monitor the evolution of the disease. This review explores the neuroimaging findings in SLE, including the recent advances in new MRI methods. PMID:26236469

  15. Advanced and Conventional Magnetic Resonance Imaging in Neuropsychiatric Lupus

    PubMed Central

    Sarbu, Nicolae; Bargalló, Núria; Cervera, Ricard

    2015-01-01

    Neuropsychiatric lupus is a major diagnostic challenge, and a main cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Magnetic resonance imaging (MRI) is, by far, the main tool for assessing the brain in this disease. Conventional and advanced MRI techniques are used to help establishing the diagnosis, to rule out alternative diagnoses, and recently, to monitor the evolution of the disease. This review explores the neuroimaging findings in SLE, including the recent advances in new MRI methods. PMID:26236469

  16. Earth Observing-1 Advanced Land Imager: Radiometric Response Calibration

    NASA Technical Reports Server (NTRS)

    Mendenhall, J. A.; Lencioni, D. E.; Evans, J. B.

    2000-01-01

    The Advanced Land Imager (ALI) is one of three instruments to be flown on the first Earth Observing mission (EO-1) under NASA's New Millennium Program (NMP). ALI contains a number of innovative features, including a wide field of view optical design, compact multispectral focal plane arrays, non-cryogenic HgCdTe detectors for the short wave infrared bands, and silicon carbide optics. This document outlines the techniques adopted during ground calibration of the radiometric response of the Advanced Land Imager. Results from system level measurements of the instrument response, signal-to-noise ratio, saturation radiance, and dynamic range for all detectors of every spectral band are also presented.

  17. Convergent Evolution of Argonaute-2 Slicer Antagonism in Two Distinct Insect RNA Viruses

    PubMed Central

    van Mierlo, Joël T.; Bronkhorst, Alfred W.; Overheul, Gijs J.; Sadanandan, Sajna A.; Ekström, Jens-Ola; Heestermans, Marco; Hultmark, Dan; Antoniewski, Christophe; van Rij, Ronald P.

    2012-01-01

    RNA interference (RNAi) is a major antiviral pathway that shapes evolution of RNA viruses. We show here that Nora virus, a natural Drosophila pathogen, is both a target and suppressor of RNAi. We detected viral small RNAs with a signature of Dicer-2 dependent small interfering RNAs in Nora virus infected Drosophila. Furthermore, we demonstrate that the Nora virus VP1 protein contains RNAi suppressive activity in vitro and in vivo that enhances pathogenicity of recombinant Sindbis virus in an RNAi dependent manner. Nora virus VP1 and the viral suppressor of RNAi of Cricket paralysis virus (1A) antagonized Argonaute-2 (AGO2) Slicer activity of RNA induced silencing complexes pre-loaded with a methylated single-stranded guide strand. The convergent evolution of AGO2 suppression in two unrelated insect RNA viruses highlights the importance of AGO2 in antiviral defense. PMID:22916019

  18. Advanced Imaging Catheter: Final Project Report

    SciTech Connect

    Krulevitch, P; Colston, B; DaSilva, L; Hilken, D; Kluiwstra, J U; Lee, A P; London, R; Miles, R; Schumann, D; Seward, K; Wang, A

    2001-07-20

    Minimally invasive surgery (MIS) is an approach whereby procedures conventionally performed with large and potentially traumatic incisions are replaced by several tiny incisions through which specialized instruments are inserted. Early MIS, often called laparoscopic surgery, used video cameras and laparoscopes to visualize and control the medical devices, which were typically cutting or stapling tools. More recently, catheter-based procedures have become a fast growing sector of all surgeries. In these procedures, small incisions are made into one of the main arteries (e.g. femoral artery in the thigh), and a long thin hollow tube is inserted and positioned near the target area. The key advantage of this technique is that recovery time can be reduced from months to a matter of days. In the United States, over 700,000 catheter procedures are performed annually representing a market of over $350 million. Further growth in this area will require significant improvements in the current catheter technology. In order to effectively navigate a catheter through the tortuous vessels of the body, two capabilities must exist: imaging and positioning. In most cases, catheter procedures rely on radiography for visualization and manual manipulation for positioning of the device. Radiography provides two-dimensional, global images of the vasculature and cannot be used continuously due to radiation exposure to both the patient and physician. Intravascular ultrasound devices are available for continuous local imaging at the catheter tip, but these devices cannot be used simultaneously with therapeutic devices. Catheters are highly compliant devices, and manipulating the catheter is similar to pushing on a string. Often, a guide wire is used to help position the catheter, but this procedure has its own set of problems. Three characteristics are used to describe catheter maneuverability: (1) pushability -- the amount of linear displacement of the distal end (inside body) relative to

  19. Imaging spectrometer technologies for advanced Earth remote sensing

    NASA Technical Reports Server (NTRS)

    Wellman, J. B.; Breckinridge, J. B.; Kuperfman, P.; Salazar, R. P.; Sigurdson, K. B.

    1982-01-01

    A major requirement of multispectral imaging systems for advanced Earth remote sensing is the provision for greater spectral resolution and more versatile spectral band selection. The imaging spectrometer instrument concept provides this versatility by the combination of pushbroom imaging and spectrally dispersing optics using area array detectors in the focal plane. The shuttle imaging spectrometer concept achieves 10- and 20-meter ground instantaneous fields of view with 20-nanometer spectral resolution from Earth Orbit. Onboard processing allows the selection of spectral bands during flight; this, in turn, permits the sensor parameters to be tailored to the experiment objectives. Advances in optical design, infrared detector arrays, and focal plane cooling indicate the feasibility of the instrument concept and support the practicability of a validation flight experiment for the shuttle in the late 1980s.

  20. Advanced digital detectors for neutron imaging.

    SciTech Connect

    Doty, F. Patrick

    2003-12-01

    Neutron interrogation provides unique information valuable for Nonproliferation & Materials Control and other important applications including medicine, airport security, protein crystallography, and corrosion detection. Neutrons probe deep inside massive objects to detect small defects and chemical composition, even through high atomic number materials such as lead. However, current detectors are bulky gas-filled tubes or scintillator/PM tubes, which severely limit many applications. Therefore this project was undertaken to develop new semiconductor radiation detection materials to develop the first direct digital imaging detectors for neutrons. The approach relied on new discovery and characterization of new solid-state sensor materials which convert neutrons directly to electronic signals via reactions BlO(n,a)Li7 and Li6(n,a)T.

  1. Advanced digital image archival system using MPEG technologies

    NASA Astrophysics Data System (ADS)

    Chang, Wo

    2009-08-01

    Digital information and records are vital to the human race regardless of the nationalities and eras in which they were produced. Digital image contents are produced at a rapid pace from cultural heritages via digitalization, scientific and experimental data via high speed imaging sensors, national defense satellite images from governments, medical and healthcare imaging records from hospitals, personal collection of photos from digital cameras. With these mass amounts of precious and irreplaceable data and knowledge, what standards technologies can be applied to preserve and yet provide an interoperable framework for accessing the data across varieties of systems and devices? This paper presents an advanced digital image archival system by applying the international standard of MPEG technologies to preserve digital image content.

  2. Technical advances of interventional fluoroscopy and flat panel image receptor.

    PubMed

    Lin, Pei-Jan Paul

    2008-11-01

    In the past decade, various radiation reducing devices and control circuits have been implemented on fluoroscopic imaging equipment. Because of the potential for lengthy fluoroscopic procedures in interventional cardiovascular angiography, these devices and control circuits have been developed for the cardiac catheterization laboratories and interventional angiography suites. Additionally, fluoroscopic systems equipped with image intensifiers have benefited from technological advances in x-ray tube, x-ray generator, and spectral shaping filter technologies. The high heat capacity x-ray tube, the medium frequency inverter generator with high performance switching capability, and the patient dose reduction spectral shaping filter had already been implemented on the image intensified fluoroscopy systems. These three underlying technologies together with the automatic dose rate and image quality (ADRIQ) control logic allow patients undergoing cardiovascular angiography procedures to benefit from "lower patient dose" with "high image quality." While photoconductor (or phosphor plate) x-ray detectors and signal capture thin film transistor (TFT) and charge coupled device (CCD) arrays are analog in nature, the advent of the flat panel image receptor allowed for fluoroscopy procedures to become more streamlined. With the analog-to-digital converter built into the data lines, the flat panel image receptor appears to become a digital device. While the transition from image intensified fluoroscopy systems to flat panel image receptor fluoroscopy systems is part of the on-going "digitization of imaging," the value of a flat panel image receptor may have to be evaluated with respect to patient dose, image quality, and clinical application capabilities. The advantage of flat panel image receptors has yet to be fully explored. For instance, the flat panel image receptor has its disadvantages as compared to the image intensifiers; the cost of the equipment is probably the most

  3. The ADIS advanced data acquisition, imaging, and storage system

    SciTech Connect

    Flaherty, J.W.

    1986-01-01

    The design and development of Automated Ultrasonic Scanning Systems (AUSS) by McDonnell Aircraft Company has provided the background for the development of the ADIS advanced data acquisition, imaging, and storage system. The ADIS provides state-of-the-art ultrasonic data processing and imaging features which can be utilized in both laboratory and production line composite evaluation applications. System features, such as, real-time imaging, instantaneous electronic rescanning, multitasking capability, histograms, and cross-sections, provide the tools necessary to inspect and evaluate composite parts quickly and consistently.

  4. Recent Advances of Radionuclide-based Molecular Imaging of Atherosclerosis

    PubMed Central

    Kazuma, Soraya M.; Sultan, Deborah; Zhao, Yongfeng; Detering, Lisa; You, Meng; Luehmann, Hannah P.; Abdalla, Dulcineia S.P.; Liu, Yongjian

    2015-01-01

    Atherosclerosis is a systemic disease characterized by the development of multifocal plaque lesions within vessel walls and extending into the vascular lumen. The disease takes decades to develop symptomatic lesions, affording opportunities for accurate detection of plaque progression, analysis of risk factors responsible for clinical events, and planning personalized treatment. Of the available molecular imaging modalities, radionuclide-based imaging strategies have been favored due to their sensitivity, quantitative detection and pathways for translational research. This review summarizes recent advances of radiolabeled small molecules, peptides, antibodies and nanoparticles for atherosclerotic plaque imaging during disease progression. PMID:26369676

  5. AXIOM: Advanced X-Ray Imaging Of the Magnetosheath

    NASA Technical Reports Server (NTRS)

    Sembay, S.; Branduardi-Rayrnont, G.; Eastwood, J. P.; Sibeck, D. G.; Abbey, A.; Brown, P.; Carter, J. A.; Carr, C. M.; Forsyth, C; Kataria, D.; Kemble, S.; Milan, S.; Owen, C. J.; Read, A. M.; Peacocke, L.; Arridge, C. S.; Coates, A. J.; Collier, M. R.; Cowley, S. W. H.; Fazakerley, A. N.; Fraser, G.; Jones, G. H.; Lallement, R.; Lester, M.; Porter, F. S.

    2012-01-01

    AXIOM (Advanced X-ray Imaging Of the Magnetosphere) is a concept mission which aims to explain how the Earth's magnetosphere responds to the changing impact of the solar wind using a unique method never attempted before; performing wide-field soft X-ray imaging and spectroscopy of the magnetosheath. magnetopause and bow shock at high spatial and temporal resolution. Global imaging of these regions is possible because of the solar wind charge exchange (SWCX) process which produces elevated soft X-ray emission from the interaction of high charge-state solar wind ions with primarily neutral hydrogen in the Earth's exosphere and near-interplanetary space.

  6. Recent advances in magnetic resonance imaging of prostate cancer

    PubMed Central

    Lawrentschuk, Nathan

    2010-01-01

    This concise review attempts to highlight the recent advances in magnetic resonance imaging (MRI) in relation to all the different aspects of prostate cancer (PCa), and outlines future implications of MRI in the diagnosis, treatment, and surveillance of PCa. PMID:21283654

  7. Establishing advanced practice for medical imaging in New Zealand

    SciTech Connect

    Yielder, Jill; Young, Adrienne; Park, Shelley; Coleman, Karen

    2014-02-15

    Introduction: This article presents the outcome and recommendations following the second stage of a role development project conducted on behalf of the New Zealand Institute of Medical Radiation Technology (NZIMRT). The study sought to support the development of profiles and criteria that may be used to formulate Advanced Scopes of Practice for the profession. It commenced in 2011, following on from initial research that occurred between 2005 and 2008 investigating role development and a possible career structure for medical radiation technologists (MRTs) in New Zealand (NZ). Methods: The study sought to support the development of profiles and criteria that could be used to develop Advanced Scopes of Practice for the profession through inviting 12 specialist medical imaging groups in NZ to participate in a survey. Results: Findings showed strong agreement on potential profiles and on generic criteria within them; however, there was less agreement on specific skills criteria within specialist areas. Conclusions: The authors recommend that one Advanced Scope of Practice be developed for Medical Imaging, with the establishment of generic and specialist criteria. Systems for approval of the overall criteria package for any individual Advanced Practitioner (AP) profile, audit and continuing professional development requirements need to be established by the Medical Radiation Technologists Board (MRTB) to meet the local needs of clinical departments. It is further recommended that the NZIMRT and MRTB promote and support the need for an AP pathway for medical imaging in NZ.

  8. Establishing advanced practice for medical imaging in New Zealand

    PubMed Central

    Yielder, Jill; Young, Adrienne; Park, Shelley; Coleman, Karen

    2014-01-01

    IntroductionThis article presents the outcome and recommendations following the second stage of a role development project conducted on behalf of the New Zealand Institute of Medical Radiation Technology (NZIMRT). The study sought to support the development of profiles and criteria that may be used to formulate Advanced Scopes of Practice for the profession. It commenced in 2011, following on from initial research that occurred between 2005 and 2008 investigating role development and a possible career structure for medical radiation technologists (MRTs) in New Zealand (NZ). MethodsThe study sought to support the development of profiles and criteria that could be used to develop Advanced Scopes of Practice for the profession through inviting 12 specialist medical imaging groups in NZ to participate in a survey. ResultsFindings showed strong agreement on potential profiles and on generic criteria within them; however, there was less agreement on specific skills criteria within specialist areas. ConclusionsThe authors recommend that one Advanced Scope of Practice be developed for Medical Imaging, with the establishment of generic and specialist criteria. Systems for approval of the overall criteria package for any individual Advanced Practitioner (AP) profile, audit and continuing professional development requirements need to be established by the Medical Radiation Technologists Board (MRTB) to meet the local needs of clinical departments. It is further recommended that the NZIMRT and MRTB promote and support the need for an AP pathway for medical imaging in NZ. PMID:26229631

  9. Challenges and recent advances in mass spectrometric imaging of neurotransmitters

    PubMed Central

    Gemperline, Erin; Chen, Bingming; Li, Lingjun

    2014-01-01

    Mass spectrometric imaging (MSI) is a powerful tool that grants the ability to investigate a broad mass range of molecules, from small molecules to large proteins, by creating detailed distribution maps of selected compounds. To date, MSI has demonstrated its versatility in the study of neurotransmitters and neuropeptides of different classes toward investigation of neurobiological functions and diseases. These studies have provided significant insight in neurobiology over the years and current technical advances are facilitating further improvements in this field. neurotransmitters, focusing specifically on the challenges and recent Herein, we advances of MSI of neurotransmitters. PMID:24568355

  10. Advances in imaging explosive blast mild traumatic brain injury.

    PubMed

    Hetherington, H; Bandak, A; Ling, G; Bandak, F A

    2015-01-01

    In the past, direct physical evidence of mild traumatic brain injury (mTBI) from explosive blast has been difficult to obtain through conventional imaging modalities such as T1- and T2-weighted magnetic resonance imaging (MRI) and computed tomography (CT). Here, we review current progress in detecting evidence of brain injury from explosive blast using advanced imaging, including diffusion tensor imaging (DTI), functional MRI (fMRI), and the metabolic imaging methods such as positron emission tomography (PET) and magnetic resonance spectroscopic imaging (MRSI), where each targets different aspects of the pathology involved in mTBI. DTI provides a highly sensitive measure to detect primary changes in the microstructure of white matter tracts. fMRI enables the measurement of changes in brain activity in response to different stimuli or tasks. Remarkably, all three of these paradigms have found significant success in conventional mTBI where conventional clinical imaging frequently fails to provide definitive differences. Additionally, although used less frequently for conventional mTBI, PET has the potential to characterize a variety of neurotransmitter systems using target agents and will undoubtedly play a larger role, once the basic mechanisms of injury are better understood and techniques to identify the injury are more common. Finally, our MRSI imaging studies, although acquired at much lower spatial resolution, have demonstrated selectivity to different metabolic and physiologic processes, uncovering some of the most profound differences on an individual by individual basis, suggesting the potential for utility in the management of individual patients.

  11. Recent advances in image-guided targeted prostate biopsy.

    PubMed

    Brown, Anna M; Elbuluk, Osama; Mertan, Francesca; Sankineni, Sandeep; Margolis, Daniel J; Wood, Bradford J; Pinto, Peter A; Choyke, Peter L; Turkbey, Baris

    2015-08-01

    Prostate cancer is a common malignancy in the United States that results in over 30,000 deaths per year. The current state of prostate cancer diagnosis, based on PSA screening and sextant biopsy, has been criticized for both overdiagnosis of low-grade tumors and underdiagnosis of clinically significant prostate cancers (Gleason score ≥7). Recently, image guidance has been added to perform targeted biopsies of lesions detected on multi-parametric magnetic resonance imaging (mpMRI) scans. These methods have improved the ability to detect clinically significant cancer, while reducing the diagnosis of low-grade tumors. Several approaches have been explored to improve the accuracy of image-guided targeted prostate biopsy, including in-bore MRI-guided, cognitive fusion, and MRI/transrectal ultrasound fusion-guided biopsy. This review will examine recent advances in these image-guided targeted prostate biopsy techniques. PMID:25596716

  12. Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection

    NASA Astrophysics Data System (ADS)

    Sinharay, Sanhita; Pagel, Mark D.

    2016-06-01

    Recent advances in magnetic resonance imaging (MRI) contrast agents have provided new capabilities for biomarker detection through molecular imaging. MRI contrast agents based on the T2 exchange mechanism have more recently expanded the armamentarium of agents for molecular imaging. Compared with T1 and T2* agents, T2 exchange agents have a slower chemical exchange rate, which improves the ability to design these MRI contrast agents with greater specificity for detecting the intended biomarker. MRI contrast agents that are detected through chemical exchange saturation transfer (CEST) have even slower chemical exchange rates. Another emerging class of MRI contrast agents uses hyperpolarized 13C to detect the agent with outstanding sensitivity. These hyperpolarized 13C agents can be used to track metabolism and monitor characteristics of the tissue microenvironment. Together, these various MRI contrast agents provide excellent opportunities to develop molecular imaging for biomarker detection.

  13. Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection

    PubMed Central

    Sinharay, Sanhita; Pagel, Mark D.

    2016-01-01

    Recent advances in magnetic resonance imaging (MRI) contrast agents have provided new capabilities for biomarker detection through molecular imaging. MRI contrast agents based on the T2 exchange mechanism have more recently expanded the armamentarium of agents for molecular imaging. Compared with T1 and T2* agents, T2 exchange agents have a slower chemical exchange rate, which improves the ability to design these MRI contrast agents with greater specificity for detecting the intended biomarker. MRI contrast agents that are detected through chemical exchange saturation transfer (CEST) have even slower chemical exchange rates. Another emerging class of MRI contrast agents uses hyperpolarized 13C to detect the agent with outstanding sensitivity. These hyperpolarized 13C agents can be used to track metabolism and monitor characteristics of the tissue microenvironment. Together, these various MRI contrast agents provide excellent opportunities to develop molecular imaging for biomarker detection. PMID:27049630

  14. Optical design and characterization of an advanced computational imaging system

    NASA Astrophysics Data System (ADS)

    Shepard, R. Hamilton; Fernandez-Cull, Christy; Raskar, Ramesh; Shi, Boxin; Barsi, Christopher; Zhao, Hang

    2014-09-01

    We describe an advanced computational imaging system with an optical architecture that enables simultaneous and dynamic pupil-plane and image-plane coding accommodating several task-specific applications. We assess the optical requirement trades associated with custom and commercial-off-the-shelf (COTS) optics and converge on the development of two low-cost and robust COTS testbeds. The first is a coded-aperture programmable pixel imager employing a digital micromirror device (DMD) for image plane per-pixel oversampling and spatial super-resolution experiments. The second is a simultaneous pupil-encoded and time-encoded imager employing a DMD for pupil apodization or a deformable mirror for wavefront coding experiments. These two testbeds are built to leverage two MIT Lincoln Laboratory focal plane arrays - an orthogonal transfer CCD with non-uniform pixel sampling and on-chip dithering and a digital readout integrated circuit (DROIC) with advanced on-chip per-pixel processing capabilities. This paper discusses the derivation of optical component requirements, optical design metrics, and performance analyses for the two testbeds built.

  15. Advanced ground-penetrating, imaging radar for bridge inspection

    SciTech Connect

    Warhus, J.P.; Mast, J.E.; Johansson, E.M.; Nelson, S.E.; Lee, Hua

    1993-08-01

    Inspecting high-value structures, like bridges and buildings using Ground Penetrating Radar (GPR) is an application of the technology that is growing in importance. In a typical inspection application, inspectors use GPR to locate structural components, like reinforcing bars embedded in concrete, to avoid weakening the structure while collecting core samples for detailed inspection. Advanced GPR, integrated with imaging technologies for use as an NDE tool, can provide the capability to locate and characterize construction flaws and wear- or age-induced damage in these structures without the need for destructive techniques like coring. In the following sections, we discuss an important inspection application, namely, concrete bridge deck inspection. We describe an advanced bridge deck inspection system concept and provide an overview of a program aimed at developing such a system. Examples of modeling, image reconstruction, and experimental results are presented.

  16. Recent advances in imaging-guided interventions for prostate cancers

    PubMed Central

    Wu, Xia; Zhang, Feng; Chen, Ran; Zheng, Weiliang; Yang, Xiaoming

    2014-01-01

    The numbers of patients diagnosed with prostate cancers is increasing due to the widespread application of prostate-specific antigen screening and subsequent prostate biopsies. The methods of systemic administration of therapeutics are not target-specific and thus cannot efficiently destroy prostate tumour cells while simultaneously sparing the surrounding normal tissues and organs. Recent advances in imaging-guided minimally invasive therapeutic techniques offer considerable potential for the effective management of prostate cancers. An objective understanding of the feasibility, effectiveness, morbidity, and deficiencies of these interventional techniques is essential for both clinical practice and scientific progress. This review presents the recent advances in imaging-guided interventional techniques for the diagnosis and treatment of prostate cancers. PMID:24769076

  17. Advanced indium antimonide monolithic charge coupled infrared imaging arrays

    NASA Technical Reports Server (NTRS)

    Koch, T. L.; Merilainen, C. A.; Thom, R. D.

    1981-01-01

    The continued process development of SiO2 insulators for use in advanced InSb monolithic charge coupled infrared imaging arrays is described. Specific investigations into the use of plasma enhanced chemical vapor deposited (PECVD) SiO2 as a gate insulator for InSb charge coupled devices is discussed, as are investigations of other chemical vapor deposited SiO2 materials.

  18. Advanced Imaging for Biopsy Guidance in Primary Brain Tumors

    PubMed Central

    Tsiouris, Apostolos J; Ramakrishna, Rohan

    2016-01-01

    Accurate glioma sampling is required for diagnosis and establishing eligibility for relevant clinical trials. MR-based perfusion and spectroscopy sequences supplement conventional MR in noninvasively predicting the areas of highest tumor grade for biopsy. We report the case of a patient with gliomatosis cerebri and multifocal patchy enhancement in whom the combination of advanced and conventional imaging attributes successfully guided a diagnostic biopsy. PMID:27014538

  19. Digital Mammography Imaging: Breast Tomosynthesis and Advanced Applications

    PubMed Central

    Helvie, Mark A.

    2011-01-01

    Synopsis This article discusses recent developments in advanced derivative technologies associated with digital mammography. Digital breast tomosynthesis – its principles, development, and early clinical trials are reviewed. Contrast enhanced digital mammography and combined imaging systems with digital mammography and ultrasound are also discussed. Although all these methods are currently research programs, they hold promise for improving cancer detection and characterization if early results are confirmed by clinical trials. PMID:20868894

  20. Advances in Magnetic Resonance Imaging of the Skull Base

    PubMed Central

    Kirsch, Claudia F.E.

    2014-01-01

    Introduction Over the past 20 years, magnetic resonance imaging (MRI) has advanced due to new techniques involving increased magnetic field strength and developments in coils and pulse sequences. These advances allow increased opportunity to delineate the complex skull base anatomy and may guide the diagnosis and treatment of the myriad of pathologies that can affect the skull base. Objectives The objective of this article is to provide a brief background of the development of MRI and illustrate advances in skull base imaging, including techniques that allow improved conspicuity, characterization, and correlative physiologic assessment of skull base pathologies. Data Synthesis Specific radiographic illustrations of increased skull base conspicuity including the lower cranial nerves, vessels, foramina, cerebrospinal fluid (CSF) leaks, and effacement of endolymph are provided. In addition, MRIs demonstrating characterization of skull base lesions, such as recurrent cholesteatoma versus granulation tissue or abscess versus tumor, are also provided as well as correlative clinical findings in CSF flow studies in a patient pre- and post-suboccipital decompression for a Chiari I malformation. Conclusions This article illustrates MRI radiographic advances over the past 20 years, which have improved clinicians' ability to diagnose, define, and hopefully improve the treatment and outcomes of patients with underlying skull base pathologies. PMID:25992137

  1. Advanced echocardiographic imaging of the congenitally malformed heart.

    PubMed

    Black, D; Vettukattil, J

    2013-08-01

    There have been significant advancements in the ability of echocardiography to provide both morphological and functional information in children with congenitally malformed hearts. This progress has come through the development of improved technology such as matrix array probes and software which allows for the off line analysis of images to a high standard. This article focuses on these developments and discusses some newer concepts in advanced echocardiography such is multi-planar reformatting [MPR] and tissue motion annular displacement [TMAD]. Our aim is to discuss important aspects related to the quality and reproducibility of data, to review the most recent published data regarding advanced echocardiography in the malformed heart and to guide the reader to appropriate text for overcoming the technical challenges of using these methods. Many of the technical aspects of image acquisition and post processing have been discussed in recent reviews by the authors and we would urge readers to study these texts to gain a greater understanding [1]. The quality of the two dimensional image is paramount in both strain analysis and three dimensional echocardiography. An awareness of how to improve image quality is vital to acquiring accurate and usable data. Three dimensional echocardiography (3DE) is an attempt to visualise the dynamic morphology of the heart. Although published media is the basis for theoretical knowledge of how to practically acquire images, electronic media [eg.www.3dechocardiography.com] is the only way of visualising the advantages of this technology in real time. It is important to be aware of the limitations of this technology and that much of the data gleaned from using these methods is at a research stage and not yet in regular clinical practice. PMID:23228075

  2. Advances in imaging secondary ion mass spectrometry for biological samples

    SciTech Connect

    Boxer, Steven G.; Kraft, Mary L.; Weber, Peter K.

    2008-12-16

    Imaging mass spectrometry combines the power of mass spectrometry to identify complex molecules based on mass with sample imaging. Recent advances in secondary ion mass spectrometry have improved sensitivity and spatial resolution, so that these methods have the potential to bridge between high-resolution structures obtained by X-ray crystallography and cyro-electron microscopy and ultrastructure visualized by conventional light microscopy. Following background information on the method and instrumentation, we address the key issue of sample preparation. Because mass spectrometry is performed in high vacuum, it is essential to preserve the lateral organization of the sample while removing bulk water, and this has been a major barrier for applications to biological systems. Furthermore, recent applications of imaging mass spectrometry to cell biology, microbial communities, and biosynthetic pathways are summarized briefly, and studies of biological membrane organization are described in greater depth.

  3. Advanced gastrointestinal endoscopic imaging for inflammatory bowel diseases

    PubMed Central

    Tontini, Gian Eugenio; Rath, Timo; Neumann, Helmut

    2016-01-01

    Gastrointestinal luminal endoscopy is of paramount importance for diagnosis, monitoring and dysplasia surveillance in patients with both, Crohn’s disease and ulcerative colitis. Moreover, with the recent recognition that mucosal healing is directly linked to the clinical outcome of patients with inflammatory bowel disorders, a growing demand exists for the precise, timely and detailed endoscopic assessment of superficial mucosal layer. Further, the novel field of molecular imaging has tremendously expanded the clinical utility and applications of modern endoscopy, now encompassing not only diagnosis, surveillance, and treatment but also the prediction of individual therapeutic responses. Within this review, we describe how novel endoscopic approaches and advanced endoscopic imaging methods such as high definition and high magnification endoscopy, dye-based and dye-less chromoendoscopy, confocal laser endomicroscopy, endocytoscopy and molecular imaging now allow for the precise and ultrastructural assessment of mucosal inflammation and describe the potential of these techniques for dysplasia detection. PMID:26811662

  4. Brain Imaging Using T-Rays Instrumentation Advances

    NASA Astrophysics Data System (ADS)

    Treviño-Palacios, C. G.; Celis-López, M. A.; Lárraga-Gutiérrez, J. M.; García-Garduño, A.; Zapata-Nava, O. J.; Díaz, A. Orduña; Torres-Jácome, A.; de-la-Hidalga-Wade, J.; Iturbe-Castillo, M. D.

    2010-12-01

    We present the advances on a brain imaging setup using submillimeter detectors and terahertz laser source. Terahertz radiation, known as T-rays, falls in the far infrared region of the electromagnetic spectrum close to the microwaves and fraction of millimeter wavelengths. These T-rays are ideal candidates for medical imaging because the wavelength is long enough to be dispersed by molecular structures and sufficient small to produce images with a reasonable resolution, in a non-ionizing way. The millimeter detectors used in this proposal are being developed in parallel to the detectors used in the large Millimeter Telescope (LMT/GTM). Using the non-ionizing water absorption to terahertz radiation by different tissues we study the absorption difference between healthy and tumors in spite of the large absorption by water present in the body.

  5. Imaging spectroscopic analysis at the Advanced Light Source

    SciTech Connect

    MacDowell, A. A.; Warwick, T.; Anders, S.; Lamble, G.M.; Martin, M.C.; McKinney, W.R.; Padmore, H.A.

    1999-05-12

    One of the major advances at the high brightness third generation synchrotrons is the dramatic improvement of imaging capability. There is a large multi-disciplinary effort underway at the ALS to develop imaging X-ray, UV and Infra-red spectroscopic analysis on a spatial scale from. a few microns to 10nm. These developments make use of light that varies in energy from 6meV to 15KeV. Imaging and spectroscopy are finding applications in surface science, bulk materials analysis, semiconductor structures, particulate contaminants, magnetic thin films, biology and environmental science. This article is an overview and status report from the developers of some of these techniques at the ALS. The following table lists all the currently available microscopes at the. ALS. This article will describe some of the microscopes and some of the early applications.

  6. Advances in imaging secondary ion mass spectrometry for biological samples

    DOE PAGES

    Boxer, Steven G.; Kraft, Mary L.; Weber, Peter K.

    2008-12-16

    Imaging mass spectrometry combines the power of mass spectrometry to identify complex molecules based on mass with sample imaging. Recent advances in secondary ion mass spectrometry have improved sensitivity and spatial resolution, so that these methods have the potential to bridge between high-resolution structures obtained by X-ray crystallography and cyro-electron microscopy and ultrastructure visualized by conventional light microscopy. Following background information on the method and instrumentation, we address the key issue of sample preparation. Because mass spectrometry is performed in high vacuum, it is essential to preserve the lateral organization of the sample while removing bulk water, and this hasmore » been a major barrier for applications to biological systems. Furthermore, recent applications of imaging mass spectrometry to cell biology, microbial communities, and biosynthetic pathways are summarized briefly, and studies of biological membrane organization are described in greater depth.« less

  7. Diagnostic imaging advances in murine models of colitis

    PubMed Central

    Brückner, Markus; Lenz, Philipp; Mücke, Marcus M; Gohar, Faekah; Willeke, Peter; Domagk, Dirk; Bettenworth, Dominik

    2016-01-01

    Inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis are chronic-remittent inflammatory disorders of the gastrointestinal tract still evoking challenging clinical diagnostic and therapeutic situations. Murine models of experimental colitis are a vital component of research into human IBD concerning questions of its complex pathogenesis or the evaluation of potential new drugs. To monitor the course of colitis, to the present day, classical parameters like histological tissue alterations or analysis of mucosal cytokine/chemokine expression often require euthanasia of animals. Recent advances mean revolutionary non-invasive imaging techniques for in vivo murine colitis diagnostics are increasingly available. These novel and emerging imaging techniques not only allow direct visualization of intestinal inflammation, but also enable molecular imaging and targeting of specific alterations of the inflamed murine mucosa. For the first time, in vivo imaging techniques allow for longitudinal examinations and evaluation of intra-individual therapeutic response. This review discusses the latest developments in the different fields of ultrasound, molecularly targeted contrast agent ultrasound, fluorescence endoscopy, confocal laser endomicroscopy as well as tomographic imaging with magnetic resonance imaging, computed tomography and fluorescence-mediated tomography, discussing their individual limitations and potential future diagnostic applications in the management of human patients with IBD. PMID:26811642

  8. Advances in Spectral-Spatial Classification of Hyperspectral Images

    NASA Technical Reports Server (NTRS)

    Fauvel, Mathieu; Tarabalka, Yuliya; Benediktsson, Jon Atli; Chanussot, Jocelyn; Tilton, James C.

    2012-01-01

    Recent advances in spectral-spatial classification of hyperspectral images are presented in this paper. Several techniques are investigated for combining both spatial and spectral information. Spatial information is extracted at the object (set of pixels) level rather than at the conventional pixel level. Mathematical morphology is first used to derive the morphological profile of the image, which includes characteristics about the size, orientation and contrast of the spatial structures present in the image. Then the morphological neighborhood is defined and used to derive additional features for classification. Classification is performed with support vector machines using the available spectral information and the extracted spatial information. Spatial post-processing is next investigated to build more homogeneous and spatially consistent thematic maps. To that end, three presegmentation techniques are applied to define regions that are used to regularize the preliminary pixel-wise thematic map. Finally, a multiple classifier system is defined to produce relevant markers that are exploited to segment the hyperspectral image with the minimum spanning forest algorithm. Experimental results conducted on three real hyperspectral images with different spatial and spectral resolutions and corresponding to various contexts are presented. They highlight the importance of spectral-spatial strategies for the accurate classification of hyperspectral images and validate the proposed methods.

  9. Recent Advances in Higher-order Multimodal Biomedical Imaging Agents

    PubMed Central

    Rieffel, James; Chitgupi, Upendra

    2015-01-01

    Advances in biomedical imaging have spurred the development of integrated multimodal scanners, usually capable of two simultaneous imaging modes. The long-term vision of higher-order multimodality is to improve diagnostics or guidance through analysis of complementary, data-rich, co-registered images. Synergies achieved through combined modalities could enable researchers to better track diverse physiological and structural events, analyze biodistribution and treatment efficacy, and compare established and emerging modalities. Higher-order multimodal approaches stand to benefit from molecular imaging probes and in recent years, contrast agents that have hypermodal characteristics have increasingly been reported in preclinical studies. Given the chemical requirements for contrast agents representing various modalities to be integrated into a single entity, higher-order multimodal agents reported so far tend to be of nanoparticulate form. To date, the majority of reported nanoparticles have included components that are active for magnetic resonance. Herein, we review recent progress in higher-order multimodal imaging agents, which span a range of material and structural classes, that have demonstrated utility in three (or more) imaging modalities. PMID:26185099

  10. Quantitative Computed Tomography and Image Analysis for Advanced Muscle Assessment

    PubMed Central

    Edmunds, Kyle Joseph; Gíslason, Magnus K.; Arnadottir, Iris D.; Marcante, Andrea; Piccione, Francesco; Gargiulo, Paolo

    2016-01-01

    Medical imaging is of particular interest in the field of translational myology, as extant literature describes the utilization of a wide variety of techniques to non-invasively recapitulate and quantity various internal and external tissue morphologies. In the clinical context, medical imaging remains a vital tool for diagnostics and investigative assessment. This review outlines the results from several investigations on the use of computed tomography (CT) and image analysis techniques to assess muscle conditions and degenerative process due to aging or pathological conditions. Herein, we detail the acquisition of spiral CT images and the use of advanced image analysis tools to characterize muscles in 2D and 3D. Results from these studies recapitulate changes in tissue composition within muscles, as visualized by the association of tissue types to specified Hounsfield Unit (HU) values for fat, loose connective tissue or atrophic muscle, and normal muscle, including fascia and tendon. We show how results from these analyses can be presented as both average HU values and compositions with respect to total muscle volumes, demonstrating the reliability of these tools to monitor, assess and characterize muscle degeneration. PMID:27478562

  11. Technology in radiology: advances in diagnostic imaging & therapeutics.

    PubMed

    Stern, S M

    1993-01-01

    Nearly 100 years from its birth, radiology continues to grow as though still in adolescence. Although some radiologic technologies have matured more than others, new applications and techniques appear regularly in the literature. Radiology has evolved from purely diagnostic devices to interventional technologies. New contrast agents in MRI, X ray and ultrasound enable physicians to make diagnoses and plan therapies with greater precision than ever before. Techniques are less and less invasive. Advances in computer technology have given supercomputer-like power to high-end nuclear medicine and MRI systems. Imaging systems in most modalities are now designed with upgrades in mind instead of "planned obsolescence." Companies routinely upgrade software and other facets of their products, sometimes at no additional charge to existing customers. Hospitals, radiology groups and imaging centers will face increasing demands to justify what they do according to patient outcomes and management criteria. Did images make the diagnosis or confirm it? Did the images determine optimal treatment strategies or confirm which strategies might be appropriate? Third-party payers, especially the government, will view radiology in those terms. The diagnostic imaging and therapy systems of today require increasingly sophisticated technical support for maintenance and repair. Hospitals, radiology groups and imaging centers will have to determine the most economic and effective ways to guarantee equipment up-time. Borrowing from the automotive industry, some radiology manufacturers have devised transtelephonic software systems to facilitate remote troubleshooting. To ensure their fiscal viability, hospitals continue to acquire new imaging and therapy technologies for competitive and access-to-services reasons.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:10129808

  12. Millimeter-Wave Imaging Technology Advancements for Plasma Diagnostics Applications

    NASA Astrophysics Data System (ADS)

    Kong, Xiangyu

    To realize fusion plant, the very first step is to understand the fundamental physics of materials under fusion conditions, i.e. to understand fusion plasmas. Our research group, Plasma Diagnostics Group, focuses on developing advanced tools for physicists to extract as much information as possible from fusion plasmas at millions degrees. The Electron Cyclotron Emission Imaging (ECEI) diagnostics is a very useful tool invented in this group to study fusion plasma electron temperature and it fluctuations. This dissertation presents millimeter wave imaging technology advances recently developed in this group to improve the ECEI system. New technologies made it more powerful to image and visualize magneto-hydrodynamics (MHD) activities and micro-turbulence in fusion plasmas. Topics of particular emphasis start from development of miniaturized elliptical substrate lens array. This novel substrate lens array replaces the previous generation substrate lens, hyper-hemispherical substrate lens, in terms of geometry. From the optical performance perspective, this substitution not only significantly simplifies the optical system with improved optical coupling, but also enhances the RF/LO coupling efficiency. By the benefit of the mini lens focusing properties, a wideband dual-dipole antenna array is carefully designed and developed. The new antenna array is optimized simultaneously for receiving both RF and LO, with sharp radiation patterns, low side-lobe levels, and less crosstalk between adjacent antennas. In addition, a high frequency antenna is also developed, which extends the frequency limit from 145 GHz to 220 GHz. This type of antenna will be used on high field operation tokamaks with toroidal fields in excess of 3 Tesla. Another important technology advance is so-called extended bandwidth double down-conversion electronics. This new electronics extends the instantaneous IF coverage from 2 to 9.2 GHz to 2 to 16.4 GHz. From the plasma point of view, it means that the

  13. The Advanced Gamma-ray Imaging System (AGIS) - Simulation Studies

    SciTech Connect

    Maier, G.; Buckley, J.; Bugaev, V.; Fegan, S.; Vassiliev, V. V.; Funk, S.; Konopelko, A.

    2008-12-24

    The Advanced Gamma-ray Imaging System (AGIS) is a US-led concept for a next-generation instrument in ground-based very-high-energy gamma-ray astronomy. The most important design requirement for AGIS is a sensitivity of about 10 times greater than current observatories like Veritas, H.E.S.S or MAGIC. We present results of simulation studies of various possible designs for AGIS. The primary characteristics of the array performance, collecting area, angular resolution, background rejection, and sensitivity are discussed.

  14. The Advanced Gamma-ray Imaging System (AGIS): Simulation studies

    SciTech Connect

    Maier, G.; Buckley, J.; Bugaev, V.; Fegan, S.; Funk, S.; Konopelko, A.; Vassiliev, V.V.; /UCLA

    2011-06-14

    The Advanced Gamma-ray Imaging System (AGIS) is a next-generation ground-based gamma-ray observatory being planned in the U.S. The anticipated sensitivity of AGIS is about one order of magnitude better than the sensitivity of current observatories, allowing it to measure gamma-ray emission from a large number of Galactic and extra-galactic sources. We present here results of simulation studies of various possible designs for AGIS. The primary characteristics of the array performance - collecting area, angular resolution, background rejection, and sensitivity - are discussed.

  15. Advances and challenges in deformable image registration: From image fusion to complex motion modelling.

    PubMed

    Schnabel, Julia A; Heinrich, Mattias P; Papież, Bartłomiej W; Brady, Sir J Michael

    2016-10-01

    Over the past 20 years, the field of medical image registration has significantly advanced from multi-modal image fusion to highly non-linear, deformable image registration for a wide range of medical applications and imaging modalities, involving the compensation and analysis of physiological organ motion or of tissue changes due to growth or disease patterns. While the original focus of image registration has predominantly been on correcting for rigid-body motion of brain image volumes acquired at different scanning sessions, often with different modalities, the advent of dedicated longitudinal and cross-sectional brain studies soon necessitated the development of more sophisticated methods that are able to detect and measure local structural or functional changes, or group differences. Moving outside of the brain, cine imaging and dynamic imaging required the development of deformable image registration to directly measure or compensate for local tissue motion. Since then, deformable image registration has become a general enabling technology. In this work we will present our own contributions to the state-of-the-art in deformable multi-modal fusion and complex motion modelling, and then discuss remaining challenges and provide future perspectives to the field.

  16. Advances and challenges in deformable image registration: From image fusion to complex motion modelling.

    PubMed

    Schnabel, Julia A; Heinrich, Mattias P; Papież, Bartłomiej W; Brady, Sir J Michael

    2016-10-01

    Over the past 20 years, the field of medical image registration has significantly advanced from multi-modal image fusion to highly non-linear, deformable image registration for a wide range of medical applications and imaging modalities, involving the compensation and analysis of physiological organ motion or of tissue changes due to growth or disease patterns. While the original focus of image registration has predominantly been on correcting for rigid-body motion of brain image volumes acquired at different scanning sessions, often with different modalities, the advent of dedicated longitudinal and cross-sectional brain studies soon necessitated the development of more sophisticated methods that are able to detect and measure local structural or functional changes, or group differences. Moving outside of the brain, cine imaging and dynamic imaging required the development of deformable image registration to directly measure or compensate for local tissue motion. Since then, deformable image registration has become a general enabling technology. In this work we will present our own contributions to the state-of-the-art in deformable multi-modal fusion and complex motion modelling, and then discuss remaining challenges and provide future perspectives to the field. PMID:27364430

  17. Advances in high-resolution imaging – techniques for three-dimensional imaging of cellular structures

    PubMed Central

    Lidke, Diane S.; Lidke, Keith A.

    2012-01-01

    A fundamental goal in biology is to determine how cellular organization is coupled to function. To achieve this goal, a better understanding of organelle composition and structure is needed. Although visualization of cellular organelles using fluorescence or electron microscopy (EM) has become a common tool for the cell biologist, recent advances are providing a clearer picture of the cell than ever before. In particular, advanced light-microscopy techniques are achieving resolutions below the diffraction limit and EM tomography provides high-resolution three-dimensional (3D) images of cellular structures. The ability to perform both fluorescence and electron microscopy on the same sample (correlative light and electron microscopy, CLEM) makes it possible to identify where a fluorescently labeled protein is located with respect to organelle structures visualized by EM. Here, we review the current state of the art in 3D biological imaging techniques with a focus on recent advances in electron microscopy and fluorescence super-resolution techniques. PMID:22685332

  18. Recent Advances in the Imaging of Frontotemporal Dementia

    PubMed Central

    Whitwell, Jennifer L.; Josephs, Keith A.

    2012-01-01

    Neuroimaging has played an important role in the characterization of the frontotemporal dementia (FTD) syndromes, demonstrating neurodegenerative signatures that can aid in the differentiation of FTD from other neurodegenerative disorders. Recent advances have been driven largely by the refinement of the clinical syndromes that underlie FTD, and by the discovery of new genetic and pathological features associated with FTD. Many new imaging techniques and modalities are also now available that allow the assessment of other aspects of brain structure and function, such as diffusion tensor imaging and resting state functional MRI. Studies have utilized these recent techniques, as well as traditional volumetric MRI, to provide further insight into disease progression across the many clinical, genetic and pathological variants of FTD. Importantly, neuroimaging signatures have been identified that will improve the clinician’s ability to predict underlying genetic and pathological features, and hence ultimately improve patient diagnosis. PMID:23015371

  19. Glaucoma Diagnosis and Monitoring Using Advanced Imaging Technologies

    PubMed Central

    Sehi, Mitra; Iverson, Shawn M

    2014-01-01

    Advanced ocular imaging technologies facilitate objective and reproducible quantification of change in glaucoma but at the same time, impose new challenges on scientists and clinicians for separating true structural change from imaging noise. This review examines time-domain and spectral-domain optical coherence tomography, confocal scanning laser ophthalmoscopy and scanning laser polarimetry technologies and discusses the diagnostic accuracy and the ability of each technique for evaluation of glaucomatous progression. A broad review of the current literature reveals that objective assessment of retinal nerve fiber layer, ganglion cell complex and optic nerve head topography may improve glaucoma monitoring when used as a complementary tool in conjunction with the clinical judgment of an expert. PMID:24470807

  20. Advances in imaging ultrastructure yield new insights into presynaptic biology

    PubMed Central

    Bruckner, Joseph J.; Zhan, Hong; O’Connor-Giles, Kate M.

    2015-01-01

    Synapses are the fundamental functional units of neural circuits, and their dysregulation has been implicated in diverse neurological disorders. At presynaptic terminals, neurotransmitter-filled synaptic vesicles are released in response to calcium influx through voltage-gated calcium channels activated by the arrival of an action potential. Decades of electrophysiological, biochemical, and genetic studies have contributed to a growing understanding of presynaptic biology. Imaging studies are yielding new insights into how synapses are organized to carry out their critical functions. The development of techniques for rapid immobilization and preservation of neuronal tissues for electron microscopy (EM) has led to a new renaissance in ultrastructural imaging that is rapidly advancing our understanding of synapse structure and function. PMID:26052269

  1. Advanced 3D imaging lidar concepts for long range sensing

    NASA Astrophysics Data System (ADS)

    Gordon, K. J.; Hiskett, P. A.; Lamb, R. A.

    2014-06-01

    Recent developments in 3D imaging lidar are presented. Long range 3D imaging using photon counting is now a possibility, offering a low-cost approach to integrated remote sensing with step changing advantages in size, weight and power compared to conventional analogue active imaging technology. We report results using a Geiger-mode array for time-of-flight, single photon counting lidar for depth profiling and determination of the shape and size of tree canopies and distributed surface reflections at a range of 9km, with 4μJ pulses with a frame rate of 100kHz using a low-cost fibre laser operating at a wavelength of λ=1.5 μm. The range resolution is less than 4cm providing very high depth resolution for target identification. This specification opens up several additional functionalities for advanced lidar, for example: absolute rangefinding and depth profiling for long range identification, optical communications, turbulence sensing and time-of-flight spectroscopy. Future concepts for 3D time-of-flight polarimetric and multispectral imaging lidar, with optical communications in a single integrated system are also proposed.

  2. Recent Advances in Techniques for Hyperspectral Image Processing

    NASA Technical Reports Server (NTRS)

    Plaza, Antonio; Benediktsson, Jon Atli; Boardman, Joseph W.; Brazile, Jason; Bruzzone, Lorenzo; Camps-Valls, Gustavo; Chanussot, Jocelyn; Fauvel, Mathieu; Gamba, Paolo; Gualtieri, Anthony; Marconcini, Mattia; Tilton, James C.; Trianni, Giovanna

    2009-01-01

    Imaging spectroscopy, also known as hyperspectral imaging, has been transformed in less than 30 years from being a sparse research tool into a commodity product available to a broad user community. Currently, there is a need for standardized data processing techniques able to take into account the special properties of hyperspectral data. In this paper, we provide a seminal view on recent advances in techniques for hyperspectral image processing. Our main focus is on the design of techniques able to deal with the highdimensional nature of the data, and to integrate the spatial and spectral information. Performance of the discussed techniques is evaluated in different analysis scenarios. To satisfy time-critical constraints in specific applications, we also develop efficient parallel implementations of some of the discussed algorithms. Combined, these parts provide an excellent snapshot of the state-of-the-art in those areas, and offer a thoughtful perspective on future potentials and emerging challenges in the design of robust hyperspectral imaging algorithms

  3. The Effectiveness of Advance Organizers on the Signification of Poetic Images

    ERIC Educational Resources Information Center

    Bayat, Nihat

    2007-01-01

    Advance organizers activate the most suitable schema to learn new material. Poetic images are signified in schemata and the elements which are not expressed may be called by advance organizers. The purpose of this investigation is to discern the effectiveness of advance organizers on the signification of poetic images. Pretest-posttest…

  4. Assessment of Cardiac Sarcoidosis with Advanced Imaging Modalities

    PubMed Central

    Akasaka, Takashi

    2014-01-01

    Sarcoidosis is a chronic systemic disease of unknown etiology that is characterized by the presence of noncaseating epithelioid granulomas, usually in multiple organs. Several studies have shown that sarcoidosis might be the result of an exaggerated granulomatous reaction after exposure to unidentified antigens in genetically susceptible individuals. Cardiac involvement may occur and lead to an adverse outcome: the heart mechanics will be affected and that causes ventricular failure, and the cardiac electrical system will be disrupted and lead to third degree atrioventricular block, malignant ventricular tachycardia, and sudden cardiac death. Thus, early diagnosis and treatment of this potentially devastating disease is critically important. However, sensitive and accurate imaging modalities have not been established. Recent studies have demonstrated the promising potential of cardiac magnetic resonance imaging (MRI) and 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) in the diagnosis and assessment of cardiac sarcoidosis (CS). In this review, we discuss the epidemiology, etiology, histological findings, and clinical features of sarcoidosis. We also introduce advanced imaging including 18F-FDG PET and cardiac MRI as more reliable diagnostic modalities for CS. PMID:25250336

  5. Advances in ultrasound imaging for congenital malformations during early gestation

    PubMed Central

    Rayburn, William F.; Jolley, Jennifer A.; Simpson, Lynn L.

    2015-01-01

    With refinement in ultrasound technology, detection of fetal structural abnormalities has improved and there have been detailed reports of the natural history and expected outcomes for many anomalies. The ability to either reassure a high-risk woman with normal intrauterine images or offer comprehensive counseling and offer options in cases of strongly suspected lethal or major malformations has shifted prenatal diagnoses to the earliest possible gestational age. When indicated, scans in early gestation are valuable in accurate gestational dating. Stricter sonographic criteria for early nonviability guard against unnecessary intervention. Most birth defects are without known risk factors, and detection of certain malformations is possible in the late first trimester. The best time for a standard complete fetal and placental scan is 18–20 weeks. In addition, certain soft anatomic markers provide clues to chromosomal aneuploidy risk. Maternal obesity and multifetal pregnancies are now more common and further limit early gestation visibility. Other advanced imaging techniques during early gestation in select cases of suspected malformations include fetal echocardiography and magnetic resonance imaging. PMID:25820190

  6. Advanced Imaging in Femoroacetabular Impingement: Current State and Future Prospects.

    PubMed

    Bittersohl, Bernd; Hosalkar, Harish S; Hesper, Tobias; Tiderius, Carl Johan; Zilkens, Christoph; Krauspe, Rüdiger

    2015-01-01

    Symptomatic femoroacetabular impingement (FAI) is now a known precursor of early osteoarthritis (OA) of the hip. In terms of clinical intervention, the decision between joint preservation and joint replacement hinges on the severity of articular cartilage degeneration. The exact threshold during the course of disease progression when the cartilage damage is irreparable remains elusive. The intention behind radiographic imaging is to accurately identify the morphology of osseous structural abnormalities and to accurately characterize the chondrolabral damage as much as possible. However, both plain radiographs and computed tomography (CT) are insensitive for articular cartilage anatomy and pathology. Advanced magnetic resonance imaging (MRI) techniques include magnetic resonance arthrography and biochemically sensitive techniques of delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), T1rho (T1ρ), T2/T2* mapping, and several others. The diagnostic performance of these techniques to evaluate cartilage degeneration could improve the ability to predict an individual patient-specific outcome with non-surgical and surgical care. This review discusses the facts and current applications of biochemical MRI for hip joint cartilage assessment covering the roles of dGEMRIC, T2/T2*, and T1ρ mapping. The basics of each technique and their specific role in FAI assessment are outlined. Current limitations and potential pitfalls as well as future directions of biochemical imaging are also outlined. PMID:26258129

  7. An advanced CCD emulator with 32MB image memory

    NASA Astrophysics Data System (ADS)

    O'Connor, P.; Fried, J.; Kotov, I.

    2012-07-01

    As part of the LSST sensor development program we have developed an advanced CCD emulator for testing new multichannel readout electronics. The emulator, based on an Altera Stratix II FPGA for timing and control, produces 4 channels of simulated video waveforms in response to an appropriate sequence of horizontal and vertical clocks. It features 40MHz, 16-bit DACs for reset and video generation, 32MB of image memory for storage of arbitrary grayscale bitmaps, and provision to simulate reset and clock feedthrough ("glitches") on the video channels. Clock inputs are qualified for proper sequences and levels before video output is generated. Binning, region of interest, and reverse clock sequences are correctly recognized and appropriate video output will be produced. Clock transitions are timestamped and can be played back to a control PC. A simplified user interface is provided via a daughter card having an ARM M3 Cortex microprocessor and miniature color LCD display and joystick. The user can select video modes from stored bitmap images, or flat, gradient, bar, chirp, or checkerboard test patterns; set clock thresholds and video output levels; and set row/column formats for image outputs. Multiple emulators can be operated in parallel to simulate complex CCDs or CCD arrays.

  8. Advanced Imaging in Femoroacetabular Impingement: Current State and Future Prospects

    PubMed Central

    Bittersohl, Bernd; Hosalkar, Harish S.; Hesper, Tobias; Tiderius, Carl Johan; Zilkens, Christoph; Krauspe, Rüdiger

    2015-01-01

    Symptomatic femoroacetabular impingement (FAI) is now a known precursor of early osteoarthritis (OA) of the hip. In terms of clinical intervention, the decision between joint preservation and joint replacement hinges on the severity of articular cartilage degeneration. The exact threshold during the course of disease progression when the cartilage damage is irreparable remains elusive. The intention behind radiographic imaging is to accurately identify the morphology of osseous structural abnormalities and to accurately characterize the chondrolabral damage as much as possible. However, both plain radiographs and computed tomography (CT) are insensitive for articular cartilage anatomy and pathology. Advanced magnetic resonance imaging (MRI) techniques include magnetic resonance arthrography and biochemically sensitive techniques of delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), T1rho (T1ρ), T2/T2* mapping, and several others. The diagnostic performance of these techniques to evaluate cartilage degeneration could improve the ability to predict an individual patient-specific outcome with non-surgical and surgical care. This review discusses the facts and current applications of biochemical MRI for hip joint cartilage assessment covering the roles of dGEMRIC, T2/T2*, and T1ρ mapping. The basics of each technique and their specific role in FAI assessment are outlined. Current limitations and potential pitfalls as well as future directions of biochemical imaging are also outlined. PMID:26258129

  9. AXIOM: Advanced X-Ray Imaging of the Magnetosphere

    NASA Technical Reports Server (NTRS)

    Branduardi-Raymont, G.; Sembay, S. F.; Eastwood, J. P.; Sibeck, D. G.; Abbey, A.; Brown, P.; Carter, J. A.; Carr, C. M.; Forsyth, C.; Kataria, D.; Kemble, S.; Milan, S. E.; Owen, C. J.; Peacocke, L.; Read, A. M.; Coates, A. J.; Collier, M. R.; Cowley, S. W. H.; Fazakerley, A. N.; Fraser, G. W.; Jones, G. H.; Lallement, R.; Lester, M.; Porter, F. S.; Yeoman, T. K.

    2011-01-01

    Planetary plasma and magnetic field environments can be studied in two complementary ways by in situ measurements, or by remote sensing. While the former provide precise information about plasma behaviour, instabilities and dynamics on local scales, the latter offers the global view necessary to understand the overall interaction of the magnetospheric plasma with the solar wind. Some parts of the Earth's magnetosphere have been remotely sensed, but the majority remains unexplored by this type of measurements. Here we propose a novel and more elegant approach employing remote X-ray imaging techniques, which are now possible thanks to the relatively recent discovery of solar wind charge exchange X-ray emissions in the vicinity of the Earth's magnetosphere. In this article we describe how an appropriately designed and located X-ray telescope, supported by simultaneous in situ measurements of the solar wind, can be used to image the dayside magnetosphere, magnetosheath and bow shock, with a temporal and spatial resolution sufficient to address several key outstanding questions concerning how the solar wind interacts with the Earth's magnetosphere on a global level. Global images of the dayside magnetospheric boundaries require vantage points well outside the magnetosphere. Our studies have led us to propose AXIOM: Advanced X-ray Imaging Of the Magnetosphere, a concept mission using a Vega launcher with a LISA Pathfinder-type Propulsion Module to place the spacecraft in a Lissajous orbit around the Earth Moon L1 point. The model payload consists of an X-ray Wide Field Imager, capable of both imaging and spectroscopy, and an in situ plasma and magnetic field measurement package. This package comprises a Proton-Alpha Sensor, designed to measure the bulk properties of the solar wind, an Ion Composition Analyser, to characterize the minor ion populations in the solar wind that cause charge exchange emission, and a Magnetometer, designed to measure the strength and direction

  10. AXIOM: Advanced X-ray Imaging of the Magnetosphere

    NASA Technical Reports Server (NTRS)

    Branduardi-Raymont, G.; Sembay, S. F.; Eastwood, J. P.; Sibeck, D. G.; Abbey, A.; Brown, P.; Carter, J. A.; Carr, C. M.; Forsyth, C.; Kataria, D.; Kemble, S.; Milan, S. E.; Owen, C. J.; Peacocke, L.; Read, A. M.; Coates, A. J.; Collier, M. R.; Cowley, S. W. H.; Fazakerley, A. N.; Fraser, G. W.; Jones, G. H.; Lallement, R.; Lester, M.; Porter, F. S.; Yeoman, T. K.

    2012-01-01

    Planetary plasma and magnetic field environments can be studied in two complementary ways - by in situ measurements, or by remote sensing. While the former provide precise information about plasma behaviour, instabilities and dynamics on local scales, the latter offers the global view necessary to understand the overall interaction of the magnetospheric plasma with the solar wind. Some parts of the Earth's magnetosphere have been remotely sensed, but the majority remains unexplored by this type of measurements. Here we propose a novel and more elegant approach employing remote X-ray imaging techniques. which are now possible thanks to the relatively recent discovery of solar wind charge exchange X-ray emissions in the vicinity of the Earth's magnetosphere. In this article we describe how an appropriately designed and located. X-ray telescope, supported by simultaneous in situ measurements of the solar wind, can be used to image the dayside magnetosphere, magnetosheath and bow shock. with a temporal and spatial resolution sufficient to address several key outstanding questions concerning how the solar wind interacts with the Earth's magnetosphere on a global level. Global images of the dayside magnetospheric boundaries require vantage points well outside the magnetosphere. Our studies have led us to propose 'AXIOM: Advanced X-ray Imaging Of the Magnetosphere', a concept mission using a Vega launcher with a LISA Pathfinder-type Propulsion Module to place the spacecraft in a Lissajous orbit around the Earth - Moon Ll point. The model payload consists of an X-ray Wide Field Imager, capable of both imaging and spectroscopy, and an in situ plasma and magnetic field measurement package. This package comprises a Proton-Alpha Sensor, designed to measure the bulk properties of the solar wind, an Ion Composition Analyser, to characterize the minor ion populations in the solar wind that cause charge exchange emission, and a Magnetometer, designed to measure the strength and

  11. AXIOM: advanced X-ray imaging of the magnetosphere

    NASA Astrophysics Data System (ADS)

    Branduardi-Raymont, Graziella; Sembay, Steve F.; Eastwood, Jonathan P.; Sibeck, David G.; Abbey, Tony A.; Brown, Patrick; Carter, Jenny A.; Carr, Chris M.; Forsyth, Colin; Kataria, Dhiren; Kemble, Steve; Milan, Steve E.; Owen, Chris J.; Peacocke, Lisa; Read, Andy M.; Coates, Andrew J.; Collier, Michael R.; Cowley, Stan W. H.; Fazakerley, Andrew N.; Fraser, George W.; Jones, Geraint H.; Lallement, Rosine; Lester, Mark; Porter, F. Scott; Yeoman, Tim K.

    2012-04-01

    Planetary plasma and magnetic field environments can be studied in two complementary ways—by in situ measurements, or by remote sensing. While the former provide precise information about plasma behaviour, instabilities and dynamics on local scales, the latter offers the global view necessary to understand the overall interaction of the magnetospheric plasma with the solar wind. Some parts of the Earth's magnetosphere have been remotely sensed, but the majority remains unexplored by this type of measurements. Here we propose a novel and more elegant approach employing remote X-ray imaging techniques, which are now possible thanks to the relatively recent discovery of solar wind charge exchange X-ray emissions in the vicinity of the Earth's magnetosphere. In this article we describe how an appropriately designed and located X-ray telescope, supported by simultaneous in situ measurements of the solar wind, can be used to image the dayside magnetosphere, magnetosheath and bow shock, with a temporal and spatial resolution sufficient to address several key outstanding questions concerning how the solar wind interacts with the Earth's magnetosphere on a global level. Global images of the dayside magnetospheric boundaries require vantage points well outside the magnetosphere. Our studies have led us to propose `AXIOM: Advanced X-ray Imaging of the Magnetosphere', a concept mission using a Vega launcher with a LISA Pathfinder-type Propulsion Module to place the spacecraft in a Lissajous orbit around the Earth-Moon L1 point. The model payload consists of an X-ray Wide Field Imager, capable of both imaging and spectroscopy, and an in situ plasma and magnetic field measurement package. This package comprises a Proton-Alpha Sensor, designed to measure the bulk properties of the solar wind, an Ion Composition Analyser, to characterise the minor ion populations in the solar wind that cause charge exchange emission, and a Magnetometer, designed to measure the strength and

  12. Modern transform design for advanced image/video coding applications

    NASA Astrophysics Data System (ADS)

    Tran, Trac D.; Topiwala, Pankaj N.

    2008-08-01

    This paper offers an overall review of recent advances in the design of modern transforms for image and video coding applications. Transforms have been an integral part of signal coding applications from the beginning, but emphasis had been on true floating-point transforms for most of that history. Recently, with the proliferation of low-power handheld multimedia devices, a new vision of integer-only transforms that provide high performance yet very low complexity has quickly gained ascendency. We explore two key design approaches to creating integer transforms, and focus on a systematic, universal method based on decomposition into lifting steps, and use of (dyadic) rational coefficients. This method provides a wealth of solutions, many of which are already in use in leading media codecs today, such as H.264, HD Photo/JPEG XR, and scalable audio. We give early indications in this paper, and more fully elsewhere.

  13. Photodetectors for the Advanced Gamma-ray Imaging System (AGIS)

    NASA Astrophysics Data System (ADS)

    Wagner, Robert G.; Advanced Gamma-ray Imaging System AGIS Collaboration

    2010-03-01

    The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation very high energy gamma-ray observatory. Design goals include an order of magnitude better sensitivity, better angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. Given the scale of AGIS, the camera must be reliable and cost effective. The Schwarzschild-Couder optical design yields a smaller plate scale than present-day Cherenkov telescopes, enabling the use of more compact, multi-pixel devices, including multianode photomultipliers or Geiger avalanche photodiodes. We present the conceptual design of the focal plane for the camera and results from testing candidate! focal plane sensors.

  14. Sharpening advanced land imager multispectral data using a sensor model

    USGS Publications Warehouse

    Lemeshewsky, G.P.; ,

    2005-01-01

    The Advanced Land Imager (ALI) instrument on NASA's Earth Observing One (EO-1) satellite provides for nine spectral bands at 30m ground sample distance (GSD) and a 10m GSD panchromatic band. This report describes an image sharpening technique where the higher spatial resolution information of the panchromatic band is used to increase the spatial resolution of ALI multispectral (MS) data. To preserve the spectral characteristics, this technique combines reported deconvolution deblurring methods for the MS data with highpass filter-based fusion methods for the Pan data. The deblurring process uses the point spread function (PSF) model of the ALI sensor. Information includes calculation of the PSF from pre-launch calibration data. Performance was evaluated using simulated ALI MS data generated by degrading the spatial resolution of high resolution IKONOS satellite MS data. A quantitative measure of performance was the error between sharpened MS data and high resolution reference. This report also compares performance with that of a reported method that includes PSF information. Preliminary results indicate improved sharpening with the method reported here.

  15. Advances in target imaging of deep Earth structure

    NASA Astrophysics Data System (ADS)

    Masson, Y.; Romanowicz, B. A.; Clouzet, P.

    2015-12-01

    A new generation of global tomographic models (Lekić and Romanowicz, 2011; French et al, 2013, 2014) has emerged with the development of accurate numerical wavefield computations in a 3D earth combined with access to enhanced HPC capabilities. These models have sharpened up mantle images and unveiled relatively small scale structures that were blurred out in previous generation models. Fingerlike structures have been found at the base of the oceanic asthenosphere, and vertically oriented broad low velocity plume conduits extend throughout the lower mantle beneath those major hotspots that are located within the perimeter of the deep mantle large low shear velocity provinces (LLSVPs). While providing new insights into our understanding of mantle dynamics, the detailed morphology of these features, requires further efforts to obtain higher resolution images. The focus of our ongoing effort is to develop advanced tomographic methods to image remote regions of the Earth at fine scales. We have developed an approach in which distant sources (located outside of the target region) are replaced by an equivalent set of local sources located at the border of the computational domain (Masson et al., 2014). A limited number of global simulations in a reference 3D earth model is then required. These simulations are computed prior to the regional inversion, while iterations of the model need to be performed only within the region of interest, potentially allowing us to include shorter periods at limited additional computational cost. Until now, the application was limited to a distribution of receivers inside the target region. This is particularly suitable for studies of upper mantle structure in regions with dense arrays (e.g. see our companion presentation Clouzet et al., this Fall AGU). Here we present our latest development that now can include teleseismic data recorded outside the imaged region. This allows us to perform regional waveform tomography in the situation where

  16. Application of Advanced Magnetic Resonance Imaging Techniques in Evaluation of the Lower Extremity

    PubMed Central

    Braun, Hillary J.; Dragoo, Jason L.; Hargreaves, Brian A.; Levenston, Marc E.; Gold, Garry E.

    2012-01-01

    Synopsis This article reviews current magnetic resonance imaging techniques for imaging the lower extremity, focusing on imaging of the knee, ankle, and hip joints. Recent advancements in MRI include imaging at 7 Tesla, using multiple receiver channels, T2* imaging, and metal suppression techniques, allowing more detailed visualization of complex anatomy, evaluation of morphological changes within articular cartilage, and imaging around orthopedic hardware. PMID:23622097

  17. The Advanced X-ray Spectroscopy and Imaging Observatory (AXSIO)

    NASA Technical Reports Server (NTRS)

    White, Nicholas E.; Bookbinder, Jay; Petre, Robert; Smith, Randall; Ptak, Andrew; Tananbaum, Harvey; Garcia, Michael

    2012-01-01

    Following recommendations from the 2010 "New Worlds, New Horizons" (NWNH) report, the Advanced X-ray Spectroscopy and Imaging Observatory (AXSIO) concept streamlines the International X-ray Observatory (IXO) mission to concentrate on the science objectives that are enabled by high-resolution spectroscopic capabilities. AXSIO will trace orbits close to the event horizon of black holes, measure black hole spin for tens of supermassive black holes (SMBH), use spectroscopy to characterize outflows and the environment of AGN during their peak activity, observe 5MBH out to redshift z=6, map bulk motions and turbulence in galaxy clusters, find the missing baryons in the cosmic web using background quasars, and observe the process of cosmic feedback where black holes and supernovae inject energy on galactic and intergalactic scales. These measurements are enabled by a 0.9 sq m collecting area at 1.25 keV, a micro calorimeter array providing high-resolution spectroscopic imaging and a deployable high efficiency grating spectrometer. AXSIO delivers a 30-fold increase in effective area for high resolution spectroscopy. The key simplifications are guided by recommendations in the NWNH panel report include a reduction in focal length from 20m to 10m, eliminating the extendable optical bench, and a reduction in the instrument complement from six to two, avoiding a movable instrument platform. A focus on spectroscopic science allows the spatial resolution requirement to be relaxed to 10 arc sec (with a 5 arc sec goal). These simplifications decrease the total mission cost to under the $2B cost to NASA recommended by NWNH. AXSIO will be available to the entire astronomical community with observing allocations based on peer-review.

  18. A collaborative enterprise for multi-stakeholder participation in the advancement of quantitative imaging.

    PubMed

    Buckler, Andrew J; Bresolin, Linda; Dunnick, N Reed; Sullivan, Daniel C

    2011-03-01

    Medical imaging has seen substantial and rapid technical advances during the past decade, including advances in image acquisition devices, processing and analysis software, and agents to enhance specificity. Traditionally, medical imaging has defined anatomy, but increasingly newer, more advanced, imaging technologies provide biochemical and physiologic information based on both static and dynamic modalities. These advanced technologies are important not only for detecting disease but for characterizing and assessing change of disease with time or therapy. Because of the rapidity of these advances, research to determine the utility of quantitative imaging in either clinical research or clinical practice has not had time to mature. Methods to appropriately develop, assess, regulate, and reimburse must be established for these advanced technologies. Efficient and methodical processes that meet the needs of stakeholders in the biomedical research community, therapeutics developers, and health care delivery enterprises will ultimately benefit individual patients. To help address this, the authors formed a collaborative program-the Quantitative Imaging Biomarker Alliance. This program draws from the very successful precedent set by the Integrating the Healthcare Enterprise effort but is adapted to the needs of imaging science. Strategic guidance supporting the development, qualification, and deployment of quantitative imaging biomarkers will lead to improved standardization of imaging tests, proof of imaging test performance, and greater use of imaging to predict the biologic behavior of tissue and monitor therapy response. These, in turn, confer value to corporate stakeholders, providing incentives to bring new and innovative products to market. PMID:21339352

  19. A collaborative enterprise for multi-stakeholder participation in the advancement of quantitative imaging.

    PubMed

    Buckler, Andrew J; Bresolin, Linda; Dunnick, N Reed; Sullivan, Daniel C

    2011-03-01

    Medical imaging has seen substantial and rapid technical advances during the past decade, including advances in image acquisition devices, processing and analysis software, and agents to enhance specificity. Traditionally, medical imaging has defined anatomy, but increasingly newer, more advanced, imaging technologies provide biochemical and physiologic information based on both static and dynamic modalities. These advanced technologies are important not only for detecting disease but for characterizing and assessing change of disease with time or therapy. Because of the rapidity of these advances, research to determine the utility of quantitative imaging in either clinical research or clinical practice has not had time to mature. Methods to appropriately develop, assess, regulate, and reimburse must be established for these advanced technologies. Efficient and methodical processes that meet the needs of stakeholders in the biomedical research community, therapeutics developers, and health care delivery enterprises will ultimately benefit individual patients. To help address this, the authors formed a collaborative program-the Quantitative Imaging Biomarker Alliance. This program draws from the very successful precedent set by the Integrating the Healthcare Enterprise effort but is adapted to the needs of imaging science. Strategic guidance supporting the development, qualification, and deployment of quantitative imaging biomarkers will lead to improved standardization of imaging tests, proof of imaging test performance, and greater use of imaging to predict the biologic behavior of tissue and monitor therapy response. These, in turn, confer value to corporate stakeholders, providing incentives to bring new and innovative products to market.

  20. Advanced imaging techniques for the study of plant growth and development.

    PubMed

    Sozzani, Rosangela; Busch, Wolfgang; Spalding, Edgar P; Benfey, Philip N

    2014-05-01

    A variety of imaging methodologies are being used to collect data for quantitative studies of plant growth and development from living plants. Multi-level data, from macroscopic to molecular, and from weeks to seconds, can be acquired. Furthermore, advances in parallelized and automated image acquisition enable the throughput to capture images from large populations of plants under specific growth conditions. Image-processing capabilities allow for 3D or 4D reconstruction of image data and automated quantification of biological features. These advances facilitate the integration of imaging data with genome-wide molecular data to enable systems-level modeling.

  1. Earth Observing-1 Advanced Land Imager: Imaging Performance On-Orbit

    NASA Technical Reports Server (NTRS)

    Hearn, D. R.

    2002-01-01

    This report analyzes the on-orbit imaging performance of the Advanced Land Imager (ALI) on the Earth Observing-1 satellite. The pre-flight calibrations are first summarized. The methods used to reconstruct and geometrically correct the image data from this push-broom sensor are described. The method used here does not refer to the position and attitude telemetry from the spacecraft. Rather, it is assumed that the image of the scene moves across the focal plane with a constant velocity, which can be ascertained from the image data itself. Next, an assortment of the images so reconstructed is presented. Color images sharpened with the 10-m panchromatic band data are shown, and the algorithm for producing them from the 30-m multispectral data is described. The approach taken for assessing spatial resolution is to compare the sharpness of features in the on-orbit image data with profiles predicted on the basis of the pre-flight calibrations. A large assortment of bridge profiles is analyzed, and very good fits to the predicted shapes are obtained. Lunar calibration scans are analyzed to examine the sharpness of the edge-spread function at the limb of the moon. The darkness of the space beyond the limb is better for this purpose than anything that could be simulated on the ground. From these scans, we find clear evidence of scattering in the optical system, as well as some weak ghost images. Scans of planets and stars are also analyzed. Stars are useful point sources of light at all wavelengths, and delineate the point-spread functions of the system. From a quarter-speed scan over the Pleiades, we find that the ALI can detect 6th magnitude stars. The quality of the reconstructed images verifies the capability of the ALI to produce Landsat-type multi spectral data. The signal-to-noise and panchromatic spatial resolution are considerably superior to those of the existing Landsat sensors. The spatial resolution is confirmed to be as good as it was designed to be.

  2. Advanced MEMS systems for optical communication and imaging

    NASA Astrophysics Data System (ADS)

    Horenstein, M. N.; Stewart, J. B.; Cornelissen, S.; Sumner, R.; Freedman, D. S.; Datta, M.; Kani, N.; Miller, P.

    2011-06-01

    Optical communication and adaptive optics have emerged as two important uses of micro-electromechanical (MEMS) devices based on electrostatic actuation. Each application uses a mirror whose surface is altered by applying voltages of up to 300 V. Previous generations of adaptive-optic mirrors were large (~1 m) and required the use of piezoelectric transducers. Beginning in the mid-1990s, a new class of small MEMS mirrors (~1 cm) were developed. These mirrors are now a commercially available, mature technology. This paper describes three advanced applications of MEMS mirrors. The first is a mirror used for corona-graphic imaging, whereby an interferometric telescope blocks the direct light from a distant star so that nearby objects such as planets can be seen. We have developed a key component of the system: a 144-channel, fully-scalable, high-voltage multiplexer that reduces power consumption to only a few hundred milliwatts. In a second application, a MEMS mirror comprises part of a two-way optical communication system in which only one node emits a laser beam. The other node is passive, incorporating a retro-reflective, electrostatic MEMS mirror that digitally encodes the reflected beam. In a third application, the short (~100-ns) pulses of a commercially-available laser rangefinder are returned by the MEMS mirror as a digital data stream. Suitable low-power drive systems comprise part of the system design.

  3. Advances in functional magnetic resonance imaging: technology and clinical applications.

    PubMed

    Dickerson, Bradford C

    2007-07-01

    Functional MRI (fMRI) is a valuable method for use by clinical investigators to study task-related brain activation in patients with neurological or neuropsychiatric illness. Despite the relative infancy of the field, the rapid adoption of this functional neuroimaging technology has resulted from, among other factors, its ready availability, its relatively high spatial and temporal resolution, and its safety as a noninvasive imaging tool that enables multiple repeated scans over the course of a longitudinal study, and thus may lend itself well as a measure in clinical drug trials. Investigators have used fMRI to identify abnormal functional brain activity during task performance in a variety of patient populations, including those with neurodegenerative, demyelinating, cerebrovascular, and other neurological disorders that highlight the potential utility of fMRI in both basic and clinical spheres of research. In addition, fMRI studies reveal processes related to neuroplasticity, including compensatory hyperactivation, which may be a universally-occurring, adaptive neural response to insult. Functional MRI is being used to study the modulatory effects of genetic risk factors for neurological disease on brain activation; it is being applied to differential diagnosis, as a predictive biomarker of disease course, and as a means to identify neural correlates of neurotherapeutic interventions. Technological advances are rapidly occurring that should provide new applications for fMRI, including improved spatial resolution, which promises to reveal novel insights into the function of fine-scale neural circuitry of the human brain in health and disease.

  4. Recent Advances in Metabolic Profiling And Imaging of Prostate Cancer

    PubMed Central

    Thapar, Roopa; Titus, Mark A

    2015-01-01

    Cancer is a metabolic disease. Cancer cells, being highly proliferative, show significant alterations in metabolic pathways such as glycolysis, respiration, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, lipid metabolism, and amino acid metabolism. Metabolites like peptides, nucleotides, products of glycolysis, the TCA cycle, fatty acids, and steroids can be an important read out of disease when characterized in biological samples such as tissues and body fluids like urine, serum, etc. The cancer metabolome has been studied since the 1960s by analytical techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Current research is focused on the identification and validation of biomarkers in the cancer metabolome that can stratify high-risk patients and distinguish between benign and advanced metastatic forms of the disease. In this review, we discuss the current state of prostate cancer metabolomics, the biomarkers that show promise in distinguishing indolent from aggressive forms of the disease, the strengths and limitations of the analytical techniques being employed, and future applications of metabolomics in diagnostic imaging and personalized medicine of prostate cancer. PMID:25632377

  5. Advanced Reservoir Imaging Using Frequency-Dependent Seismic Attributes

    SciTech Connect

    Fred Hilterman; Tad Patzek; Gennady Goloshubin; Dmitriy Silin; Charlotte Sullivan; Valeri Korneev

    2007-12-31

    Our report concerning advanced imaging and interpretation technology includes the development of theory, the implementation of laboratory experiments and the verification of results using field data. We investigated a reflectivity model for porous fluid-saturated reservoirs and demonstrated that the frequency-dependent component of the reflection coefficient is asymptotically proportional to the reservoir fluid mobility. We also analyzed seismic data using different azimuths and offsets over physical models of fractures filled with air and water. By comparing our physical model synthetics to numerical data we have identified several diagnostic indicators for quantifying the fractures. Finally, we developed reflectivity transforms for predicting pore fluid and lithology using rock-property statistics from 500 reservoirs in both the shelf and deep-water Gulf of Mexico. With these transforms and seismic AVO gathers across the prospect and its down-dip water-equivalent reservoir, fluid saturation can be estimated without a calibration well that ties the seismic. Our research provides the important additional mechanisms to recognize, delineate, and validate new hydrocarbon reserves and assist in the development of producing fields.

  6. Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging

    PubMed Central

    Shimojo, Masafumi; Higuchi, Makoto; Suhara, Tetsuya; Sahara, Naruhiko

    2015-01-01

    The rapid progress in advanced imaging technologies has expanded our toolbox for monitoring a variety of biological aspects in living subjects including human. In vivo radiological imaging using small chemical tracers, such as with positron emission tomography, represents an especially vital breakthrough in the efforts to improve our understanding of the complicated cascade of neurodegenerative disorders including Alzheimer's disease (AD), and it has provided the most reliable visible biomarkers for enabling clinical diagnosis. At the same time, in combination with genetically modified animal model systems, the most recent innovation of fluorescence imaging is helping establish diverse applications in basic neuroscience research, from single-molecule analysis to animal behavior manipulation, suggesting the potential utility of fluorescence technology for dissecting the detailed molecular-based consequence of AD pathophysiology. In this review, our primary focus is on a current update of PET radiotracers and fluorescence indicators beneficial for understanding the AD cascade, and discussion of the utility and pitfalls of those imaging modalities for future translational research applications. We will also highlight current cutting-edge genetic approaches and discuss how to integrate individual technologies for further potential innovations. PMID:26733795

  7. The Advanced Gamma-Ray Imaging System (AGIS): Science Highlights

    SciTech Connect

    Buckley, J.; Coppi, P.; Digel, S.; Funk, S.; Krawczynski, H.; Krennrich, F.; Pohl, M.; Romani, R.; Vassiliev, V.; /UCLA

    2011-11-21

    The Advanced Gamma-ray Imaging System (AGIS), a future gamma-ray telescope consisting of an array of {approx}50 atmospheric Cherenkov telescopes distributed over an area of {approx}1 km{sup 2}, will provide a powerful new tool for exploring the high-energy universe. The order-of-magnitude increase in sensitivity and improved angular resolution could provide the first detailed images of {gamma}-ray emission from other nearby galaxies or galaxy clusters. The large effective area will provide unprecedented sensitivity to short transients (such as flares from AGNs and GRBs) probing both intrinsic spectral variability (revealing the details of the acceleration mechanism and geometry) as well as constraining the high-energy dispersion in the velocity of light (probing the structure of spacetime and Lorentz invariance). A wide field of view ({approx}4 times that of current instruments) and excellent angular resolution (several times better than current instruments) will allow for an unprecedented survey of the Galactic plane, providing a deep unobscured survey of SNRs, X-ray binaries, pulsar-wind nebulae, molecular cloud complexes and other sources. The differential flux sensitivity of {approx}10{sup -13} erg cm{sup -2} sec{sup -1} will rival the most sensitive X-ray instruments for these extended Galactic sources. The excellent capabilities of AGIS at energies below 100 GeV will provide sensitivity to AGN and GRBs out to cosmological redshifts, increasing the number of AGNs detected at high energies from about 20 to more than 100, permitting population studies that will provide valuable insights into both a unified model for AGN and a detailed measurement of the effects of intergalactic absorption from the diffuse extragalactic background light. A new instrument with fast-slewing wide-field telescopes could provide detections of a number of long-duration GRBs providing important physical constraints from this new spectral component. The new array will also have excellent

  8. Advances in Clinical and Biomedical Applications of Photoacoustic Imaging

    PubMed Central

    Su, Jimmy L.; Wang, Bo; Wilson, Katheryne E.; Bayer, Carolyn L.; Chen, Yun-Sheng; Kim, Seungsoo; Homan, Kimberly A.; Emelianov, Stanislav Y.

    2010-01-01

    Importance of the field Photoacoustic imaging is an imaging modality that derives image contrast from the optical absorption coefficient of the tissue being imaged. The imaging technique is able to differentiate between healthy and diseased tissue with either deeper penetration or higher resolution than other functional imaging modalities currently available. From a clinical standpoint, photoacoustic imaging has demonstrated safety and effectiveness in diagnosing diseased tissue regions using either endogenous tissue contrast or exogenous contrast agents. Furthermore, the potential of photoacoustic imaging has been demonstrated in various therapeutic interventions ranging from drug delivery and release to image-guided therapy and monitoring. Areas covered in this review This article reviews the current state of photoacoustic imaging in biomedicine from a technological perspective, highlights various biomedical and clinical applications of photoacoustic imaging, and gives insights on future directions. What the reader will gain Readers will learn about the various applications of photoacoustic imaging, as well as the various contrast agents that can be used to assist photoacoustic imaging. This review will highlight both pre-clinical and clinical uses for photoacoustic imaging, as well as discuss some of the challenges that must be addressed to move photoacoustic imaging into the clinical realm. Take home message Photoacoustic imaging offers unique advantages over existing imaging modalities. The imaging field is broad with many exciting applications for detecting and diagnosing diseased tissue or processes. Photoacoustics is also used in therapeutic applications to identify and characterize the pathology and then to monitor the treatment. Although the technology is still in its infancy, much work has been done in the pre-clinical arena, and photoacoustic imaging is fast approaching the clinical setting. PMID:21344060

  9. Advanced magneto-optical microscopy: Imaging from picoseconds to centimeters - imaging spin waves and temperature distributions (invited)

    NASA Astrophysics Data System (ADS)

    Urs, Necdet Onur; Mozooni, Babak; Mazalski, Piotr; Kustov, Mikhail; Hayes, Patrick; Deldar, Shayan; Quandt, Eckhard; McCord, Jeffrey

    2016-05-01

    Recent developments in the observation of magnetic domains and domain walls by wide-field optical microscopy based on the magneto-optical Kerr, Faraday, Voigt, and Gradient effect are reviewed. Emphasis is given to the existence of higher order magneto-optical effects for advanced magnetic imaging. Fundamental concepts and advances in methodology are discussed that allow for imaging of magnetic domains on various length and time scales. Time-resolved imaging of electric field induced domain wall rotation is shown. Visualization of magnetization dynamics down to picosecond temporal resolution for the imaging of spin-waves and magneto-optical multi-effect domain imaging techniques for obtaining vectorial information are demonstrated. Beyond conventional domain imaging, the use of a magneto-optical indicator technique for local temperature sensing is shown.

  10. English 591, 592, and 593--Advance Program: Images of Man.

    ERIC Educational Resources Information Center

    Jefferson County Board of Education, Louisville, KY.

    For those students who qualify, the Advance Program offers an opportunity to follow a stimulating curriculum designed for the academically talented. The purposes of the course outlined in this guide for twelfth grade English are to bring the previous three years' studies in Advance Program English to a meaningful culmination; to provide a…

  11. Advanced Millimeter-Wave Imaging Enhances Security Screening

    SciTech Connect

    Sheen, David M.; Bernacki, Bruce E.; McMakin, Douglas L.

    2012-01-12

    Millimeter-wave imaging is rapidly gaining acceptance for passenger screening at airports and other secured facilities. This paper details a number of techniques developed over the last several years including novel image reconstruction and display techniques, polarimetric imaging techniques, array switching schemes, as well as high frequency high bandwidth techniques. Implementation of some of these methods will increase the cost and complexity of the mm-wave security portal imaging systems. RF photonic methods may provide new solutions to the design and development of the sequentially switched linear mm-wave arrays that are the key element in the mm-wave portal imaging systems.

  12. Advanced Millimeter-Wave Security Portal Imaging Techniques

    SciTech Connect

    Sheen, David M.; Bernacki, Bruce E.; McMakin, Douglas L.

    2012-04-01

    Millimeter-wave imaging is rapidly gaining acceptance for passenger screening at airports and other secured facilities. This paper details a number of techniques developed over the last several years including novel image reconstruction and display techniques, polarimetric imaging techniques, array switching schemes, as well as high frequency high bandwidth techniques. Implementation of some of these methods will increase the cost and complexity of the mm-wave security portal imaging systems. RF photonic methods may provide new solutions to the design and development of the sequentially switched linear mm-wave arrays that are the key element in the mm-wave portal imaging systems.

  13. The Slicer Activity of ARGONAUTE1 Is Required Specifically for the Phasing, Not Production, of Trans-Acting Short Interfering RNAs in Arabidopsis[OPEN

    PubMed Central

    Marchais, Antonin; Poulsen, Christian; Hauptmann, Judith; Meister, Gunter

    2016-01-01

    ARGONAUTE1 (AGO1) mediates posttranscriptional silencing by microRNAs (miRNAs) and short interfering RNAS (siRNAs). AGO1-catalyzed RNA cleavage (slicing) represses miRNA targets, but current models also highlight the roles of slicing in formation of siRNAs and siRNA-AGO1 complexes. miRNA-guided slicing is required for biogenesis of phased, trans-acting siRNAs (tasiRNAs), whose cleaved precursor fragments are converted to double-stranded RNA by RNA-dependent RNA polymerase 6 (RDR6). In addition, unwinding of duplex siRNA bound to AGO1 requires passenger strand cleavage in vitro. In this study, we analyze how mutation of four metal ion-coordinating residues of Arabidopsis thaliana AGO1 affects slicer activity in vitro and siRNA function in vivo. We show that while all four residues are required for slicer activity, they do not contribute equally to catalysis. Moreover, passenger strand cleavage is required for assembly of active AGO1-siRNA complexes in vivo, and many AGO1-bound siRNAs are trimmed in the absence of slicer activity. Remarkably, seedlings defective in AGO1 slicer activity produce abundant siRNAs from tasiRNA loci in vivo. These siRNAs depend on RDR6 and SUPPRESSOR OF GENE SILENCING3, but unlike wild-type tasiRNAs, they are unphased. These results demonstrate that slicing is solely required for phase definition of tasiRNAs, and they strongly support recruitment of RDR6 by AGO1 rather than by cleavage fragments. PMID:27354557

  14. Advanced photoacoustic image reconstruction using the k-Wave toolbox

    NASA Astrophysics Data System (ADS)

    Treeby, B. E.; Jaros, J.; Cox, B. T.

    2016-03-01

    Reconstructing images from measured time domain signals is an essential step in tomography-mode photoacoustic imaging. However, in practice, there are many complicating factors that make it difficult to obtain high-resolution images. These include incomplete or undersampled data, filtering effects, acoustic and optical attenuation, and uncertainties in the material parameters. Here, the processing and image reconstruction steps routinely used by the Photoacoustic Imaging Group at University College London are discussed. These include correction for acoustic and optical attenuation, spatial resampling, material parameter selection, image reconstruction, and log compression. The effect of each of these steps is demonstrated using a representative in vivo dataset. All of the algorithms discussed form part of the open-source k-Wave toolbox (available from http://www.k-wave.org).

  15. Recent advances on in vivo imaging with fluorescent proteins.

    PubMed

    Hoffman, Robert M

    2008-01-01

    In vivo imaging with green fluorescent protein (GFP) and other fluorescent proteins is revolutionizing cancer biology and other fields of in vivo biology (Hoffman, 2005; Hoffman and Yang, 2006a,b,c). Our laboratory pioneered the use of GFP for in vivo imaging in 1997 (Chishima et al., 1997). This chapter highlights recent developments from our laboratory on both macro and micro in vivo imaging by using fluorescent proteins.

  16. Recent Advances in Image Assisted Neurosurgical Procedures: Improved Navigational Accuracy and Patient Safety

    ScienceCinema

    Olivi, Alessandro, M.D.

    2016-07-12

    Neurosurgical procedures require precise planning and intraoperative support. Recent advances in image guided technology have provided neurosurgeons with improved navigational support for more effective and safer procedures. A number of exemplary cases will be presented.

  17. Recent Advances in Image Assisted Neurosurgical Procedures: Improved Navigational Accuracy and Patient Safety

    SciTech Connect

    Olivi, Alessandro, M.D.

    2010-08-28

    Neurosurgical procedures require precise planning and intraoperative support. Recent advances in image guided technology have provided neurosurgeons with improved navigational support for more effective and safer procedures. A number of exemplary cases will be presented.

  18. Carbon nanotubes for biomedical imaging: the recent advances.

    PubMed

    Gong, Hua; Peng, Rui; Liu, Zhuang

    2013-12-01

    This article reviews the latest progresses regarding the applications of carbon nanotubes (CNTs), including single-walled carbon nanotubes (SWNTs) and multi-walled carbon nanotubes (MWNTs), as multifunctional nano-probes for biomedical imaging. Utilizing the intrinsic band-gap fluorescence of semi-conducting single-walled carbon nanotubes (SWNTs), fluorescence imaging in the near infrared II (NIR-II) region with enhanced tissue penetration and spatial resolution has shown great promise in recent years. Raman imaging based on the resonance Raman scattering of SWNTs has also been explored by a number of groups for in vitro and in vivo imaging of biological samples. The strong absorbance of CNTs in the NIR region can be used for photoacoustic imaging, and their photoacoustic signals can be dramatically enhanced by adding organic dyes, or coating with gold shells. Taking advantages of metal nanoparticle impurities attached to nanotubes, CNTs can also serve as a T2-contrast agent in magnetic resonance (MR) imaging. In addition, when labeled with radioactive isotopes, many groups have developed nuclear imaging with functionalized CNTs. Therefore CNTs are unique imaging probes with great potential in biomedical multimodal imaging.

  19. The Advancing Clinical Impact of Molecular Imaging in Cardiovascular Disease

    PubMed Central

    Osborn, Eric A; Jaffer, Farouc A

    2013-01-01

    Molecular imaging seeks to unravel critical molecular and cellular events in living subjects by providing complementary biological information to current structural clinical imaging modalities. In recent years, molecular imaging efforts have marched forward into the clinical cardiovascular arena, and are now actively illuminating new biology in a broad range of conditions, including atherosclerosis, myocardial infarction, thrombosis, vasculitis, aneurysm, cardiomyopathy, and valvular disease. Development of novel molecular imaging reporters is occurring for many clinical cardiovascular imaging modalities (PET, SPECT, MRI), as well in translational platforms such as intravascular fluorescence imaging. The ability to image, track, and quantify molecular biomarkers in organs not routinely amenable to biopsy (e.g. the heart and vasculature) open new clinical opportunities to tailor therapeutics based on a cardiovascular disease molecular profile. In addition, molecular imaging is playing an increasing role in atherosclerosis drug development in Phase II clinical trials. Here we present state-of-the-art clinical cardiovascular molecular imaging strategies, and explore promising translational approaches positioned for clinical testing in the near term. PMID:24332285

  20. IR camera system with an advanced image processing technologies

    NASA Astrophysics Data System (ADS)

    Ohkubo, Syuichi; Tamura, Tetsuo

    2016-05-01

    We have developed image processing technologies for resolving issues caused by the inherent UFPA (uncooled focal plane array) sensor characteristics to spread its applications. For example, large time constant of an uncooled IR (infra-red) sensor limits its application field, because motion blur is caused in monitoring the objective moving at high speed. The developed image processing technologies can eliminate the blur and retrieve almost the equivalent image observed in still motion. This image processing is based on the idea that output of the IR sensor is construed as the convolution of radiated IR energy from the objective and impulse response of the IR sensor. With knowledge of the impulse response and moving speed of the objective, the IR energy from the objective can be de-convolved from the observed images. We have successfully retrieved the image without blur using the IR sensor of 15 ms time constant under the conditions in which the objective is moving at the speed of about 10 pixels/60 Hz. The image processing for reducing FPN (fixed pattern noise) has also been developed. UFPA having the responsivity in the narrow wavelength region, e.g., around 8 μm is appropriate for measuring the surface of glass. However, it suffers from severe FPN due to lower sensitivity compared with 8-13 μm. The developed image processing exploits the images of the shutter itself, and can reduce FPN significantly.

  1. Advances in passive imaging elements with micromirror array

    NASA Astrophysics Data System (ADS)

    Maekawa, Satoshi; Nitta, Kouichi; Matoba, Osamu

    2008-02-01

    We have proposed a new passive imaging optics which consists of a grid array of micro roof mirrors working as dihedral corner reflectors. Although this element forms mirror-like images at opposite side of objects, the images are real. Because the imaging principle of the proposed element is based on accumulation of rays, the design of each light path makes many kinds of devices possible. So, we propose two variations of such a device. One device consists of an array of micro retroreflectors and a half mirror, and it can also form real mirror-like images. The advantage of this device is wide range of view, because the displacement of each retororeflector is not limited on a plane unlike the roof mirror grid array. The other consists of an array of long dihedral corner reflectors. Although this structure has been already known as a roof mirror array, it can be used for imaging. This device forms two heterogeneous images. One is real at the same side of an object, and the other is virtual at the opposite side. This is a conjugate imaging optics of a slit mirror array whose mirror surface is perpendicular to the device surface. The advantage of a roor mirror array is that the real image has horizontal parallax and can be seen in air naturally.

  2. MO-C-BRE-01: The WMIS-AAPM Joint Symposium: Advances in Molecular Imaging

    SciTech Connect

    Contag, C; Pogue, B; Lewis, J

    2014-06-15

    This joint symposium of the World Molecular Imaging Society (WMIS) and the AAPM includes three luminary speakers discussing work in new paradigms of molecular imaging in cancer (Contag), applications of optical imaging technologies to radiation therapy (Pogue) and an update on PET imaging as a surrogate biomarker for cancer progression and response to therapy. Learning Objectives: Appreciate the current trends in molecular and systems imaging. Understand how optical imaging technologies, and particularly Cerenkov detectors, can be used in advancing radiation oncology. Stay current on new PET tracers - and targets - of interest in cancer treatment.

  3. Advances in targeting strategies for nanoparticles in cancer imaging and therapy

    NASA Astrophysics Data System (ADS)

    YheeThese Authors Contributed The Same., Ji Young; Lee, Sangmin; Kim, Kwangmeyung

    2014-10-01

    In the last decade, nanoparticles have offered great advances in diagnostic imaging and targeted drug delivery. In particular, nanoparticles have provided remarkable progress in cancer imaging and therapy based on materials science and biochemical engineering technology. Researchers constantly attempted to develop the nanoparticles which can deliver drugs more specifically to cancer cells, and these efforts brought the advances in the targeting strategy of nanoparticles. This minireview will discuss the progress in targeting strategies for nanoparticles focused on the recent innovative work for nanomedicine.

  4. [Advances in infrared spectrum zoom imaging system research].

    PubMed

    Bai, Yu; Xing, Ting-wen; Jiang, Ya-dong

    2014-12-01

    Compared with the infrared spectrum fixed focal length system and infrared spectrum dual-zoom system, infrared spectrum continuous zoom imaging system which has continuous variational field of view can track targets sequentially, so it is a research direction in infrared spectrum imaging technology. Some new technologies are presented overseas in order to improve the detection performance, reduce cost and have good athermalized performance in infrared spectrum continuous zoom imaging system. Infrared material, infrared detector and variable aperture, those new technologies are su mmarized and the idiographic application of those new technologies in infrared spectrum continuous zoom imaging system are presented in the paper, for example athermalization of an infrared spectrum zoom lens system with new infrared material for target detection, dual band infrared spectrum continuous zoom imaging system with mid-wave infrared and long-wave infrared, infrared spectrum continuous zoom imaging system with high ratio, nfrared spectrum continuous zoom imaging system with dual F/number. It is useful for the development of chinese infrared continuous zoom imaging system.

  5. PIFEX: An advanced programmable pipelined-image processor

    NASA Technical Reports Server (NTRS)

    Gennery, D. B.; Wilcox, B.

    1985-01-01

    PIFEX is a pipelined-image processor being built in the JPL Robotics Lab. It will operate on digitized raster-scanned images (at 60 frames per second for images up to about 300 by 400 and at lesser rates for larger images), performing a variety of operations simultaneously under program control. It thus is a powerful, flexible tool for image processing and low-level computer vision. It also has applications in other two-dimensional problems such as route planning for obstacle avoidance and the numerical solution of two-dimensional partial differential equations (although its low numerical precision limits its use in the latter field). The concept and design of PIFEX are described herein, and some examples of its use are given.

  6. 3D Imaging with Structured Illumination for Advanced Security Applications

    SciTech Connect

    Birch, Gabriel Carisle; Dagel, Amber Lynn; Kast, Brian A.; Smith, Collin S.

    2015-09-01

    Three-dimensional (3D) information in a physical security system is a highly useful dis- criminator. The two-dimensional data from an imaging systems fails to provide target dis- tance and three-dimensional motion vector, which can be used to reduce nuisance alarm rates and increase system effectiveness. However, 3D imaging devices designed primarily for use in physical security systems are uncommon. This report discusses an architecture favorable to physical security systems; an inexpensive snapshot 3D imaging system utilizing a simple illumination system. The method of acquiring 3D data, tests to understand illumination de- sign, and software modifications possible to maximize information gathering capability are discussed.

  7. Visualizing Chemistry: The Progess and Promise of Advanced Chemical Imaging

    SciTech Connect

    Committee on Revealing Chemistry Through Advanced Chemical Imaging

    2006-09-01

    The field of chemical imaging can provide detailed structural, functional, and applicable information about chemistry and chemical engineering phenomena that have enormous impacts on medicine, materials, and technology. In recognizing the potential for more research development in the field of chemical imaging, the National Academies was asked by the National Science Foundation, Department of Energy, U.S. Army, and National Cancer Institute to complete a study that would review the current state of molecular imaging technology, point to promising future developments and their applications, and suggest a research and educational agenda to enable breakthrough improvements in the ability to image molecular processes simultaneously in multiple physical dimensions as well as time. The study resulted in a consensus report that provides guidance for a focused research and development program in chemical imaging and identifies research needs and possible applications of imaging technologies that can provide the breakthrough knowledge in chemistry, materials science, biology, and engineering for which we should strive. Public release of this report is expected in early October.

  8. Advances in Hyperspectral and Multispectral Image Fusion and Spectral Unmixing

    NASA Astrophysics Data System (ADS)

    Lanaras, C.; Baltsavias, E.; Schindler, K.

    2015-08-01

    In this work, we jointly process high spectral and high geometric resolution images and exploit their synergies to (a) generate a fused image of high spectral and geometric resolution; and (b) improve (linear) spectral unmixing of hyperspectral endmembers at subpixel level w.r.t. the pixel size of the hyperspectral image. We assume that the two images are radiometrically corrected and geometrically co-registered. The scientific contributions of this work are (a) a simultaneous approach to image fusion and hyperspectral unmixing, (b) enforcing several physically plausible constraints during unmixing that are all well-known, but typically not used in combination, and (c) the use of efficient, state-of-the-art mathematical optimization tools to implement the processing. The results of our joint fusion and unmixing has the potential to enable more accurate and detailed semantic interpretation of objects and their properties in hyperspectral and multispectral images, with applications in environmental mapping, monitoring and change detection. In our experiments, the proposed method always improves the fusion compared to competing methods, reducing RMSE between 4% and 53%.

  9. Advanced millimeter-wave security portal imaging techniques

    NASA Astrophysics Data System (ADS)

    Sheen, David M.; Bernacki, Bruce E.; McMakin, Douglas L.

    2012-03-01

    Millimeter-wave (mm-wave) imaging is rapidly gaining acceptance as a security tool to augment conventional metal detectors and baggage x-ray systems for passenger screening at airports and other secured facilities. This acceptance indicates that the technology has matured; however, many potential improvements can yet be realized. The authors have developed a number of techniques over the last several years including novel image reconstruction and display techniques, polarimetric imaging techniques, array switching schemes, and high-frequency high-bandwidth techniques. All of these may improve the performance of new systems; however, some of these techniques will increase the cost and complexity of the mm-wave security portal imaging systems. Reducing this cost may require the development of novel array designs. In particular, RF photonic methods may provide new solutions to the design and development of the sequentially switched linear mm-wave arrays that are the key element in the mm-wave portal imaging systems. Highfrequency, high-bandwidth designs are difficult to achieve with conventional mm-wave electronic devices, and RF photonic devices may be a practical alternative. In this paper, the mm-wave imaging techniques developed at PNNL are reviewed and the potential for implementing RF photonic mm-wave array designs is explored.

  10. 78 FR 18287 - Passenger Screening Using Advanced Imaging Technology

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... confirmed that both the backscatter and millimeter wave technologies are safe because the x-ray or radio... bottled liquid scanners, advanced technology x-ray systems, explosives trace detection (ETD) units, and...-through explosive detection portals, document scanners, shoe scanners, and backscatter x-ray...

  11. Constructing a prior information base for river mapping from digital images and DEMs by an advanced image interpretation system

    NASA Astrophysics Data System (ADS)

    Demirkesen, Ali Can

    The purpose of this dissertation is to describe the construction of a prior information-base (interpretation of river characteristics) for river mapping from digital representations, such as remotely sensed digital images and DEMs, by an advanced image interpretation system. More reliable prior information availability in an advanced image interpretation system enables GIS and remote sensing facilities to locate rivers in an easier, more accurate and more straightforward way. In this study, the author proposes a prior information-base including some rules and facts for river mapping from the use of both remotely sensed multi-spectral images and DEMs. These rules not only allow water-related applications in both GIS and remote sensing to be more accurate, but also construct the information-base for river mapping by an advanced image interpretation system. These rules were constructed as a synthesis from searching the literature and experiments with both digital images and DEMs. These rules are employed in an advanced image interpretation system which requires (1) a prior information-base; (2) a working memory; (3) an inference module (Caelli and Bischof, 1997; Schenk and Zilberstein, 1990). A prior information-base is formed by a set of rules (qualitative or quantitative or relationships). A working memory has the basic function of holding features in the form of spatial data and their attribute values. These spatial and attribute data are used by interpreters to activate the rules. Inference module refers to software and hardware that connect the user's questions to the prior information-base and instruct the user (interpreter) about the process. In this dissertation, a prior information-based river mapping was implemented and the proposed rules were tested studying both images and DEMs in IDRISI, as well as RiverTools.

  12. The new kid on the block for advanced imaging in Barrett’s esophagus: a review of volumetric laser endomicroscopy

    PubMed Central

    Trindade, Arvind J.; Smith, Michael S.; Pleskow, Douglas K.

    2016-01-01

    Advanced imaging techniques used in the management of Barrett’s esophagus include electronic imaging enhancement (e.g. narrow band imaging, flexible spectral imaging color enhancement, and i-Scan), chromoendoscopy, and confocal laser endomicroscopy. Electronic imaging enhancement is used frequently in daily practice, but use of the other advanced technologies is not routine. High-definition white light endoscopy and random four quadrant biopsy remain the standard of care for evaluation of Barrett’s esophagus; this is largely due to the value of advanced imaging technologies not having been validated in large studies or in everyday practice. A new advanced imaging technology called volumetric laser endomicroscopy is commercially available in the United States. Its ease of use and rapid acquisition of high-resolution images make this technology very promising for widespread application. In this article we review the technology and its potential for advanced imaging in Barrett’s esophagus. PMID:27134668

  13. Three dimensional optical coherence tomography imaging: advantages and advances.

    PubMed

    Gabriele, Michelle L; Wollstein, Gadi; Ishikawa, Hiroshi; Xu, Juan; Kim, Jongsick; Kagemann, Larry; Folio, Lindsey S; Schuman, Joel S

    2010-11-01

    Three dimensional (3D) ophthalmic imaging using optical coherence tomography (OCT) has revolutionized assessment of the eye, the retina in particular. Recent technological improvements have made the acquisition of 3D-OCT datasets feasible. However, while volumetric data can improve disease diagnosis and follow-up, novel image analysis techniques are now necessary in order to process the dense 3D-OCT dataset. Fundamental software improvements include methods for correcting subject eye motion, segmenting structures or volumes of interest, extracting relevant data post hoc and signal averaging to improve delineation of retinal layers. In addition, innovative methods for image display, such as C-mode sectioning, provide a unique viewing perspective and may improve interpretation of OCT images of pathologic structures. While all of these methods are being developed, most remain in an immature state. This review describes the current status of 3D-OCT scanning and interpretation, and discusses the need for standardization of clinical protocols as well as the potential benefits of 3D-OCT scanning that could come when software methods for fully exploiting these rich datasets are available clinically. The implications of new image analysis approaches include improved reproducibility of measurements garnered from 3D-OCT, which may then help improve disease discrimination and progression detection. In addition, 3D-OCT offers the potential for preoperative surgical planning and intraoperative surgical guidance.

  14. Advances in engineering of high contrast CARS imaging endoscopes.

    PubMed

    Deladurantaye, Pascal; Paquet, Alex; Paré, Claude; Zheng, Huimin; Doucet, Michel; Gay, David; Poirier, Michel; Cormier, Jean-François; Mermut, Ozzy; Wilson, Brian C; Seibel, Eric J

    2014-10-20

    The translation of CARS imaging towards real time, high resolution, chemically selective endoscopic tissue imaging applications is limited by a lack of sensitivity in CARS scanning probes sufficiently small for incorporation into endoscopes. We have developed here a custom double clad fiber (DCF)-based CARS probe which is designed to suppress the contaminant Four-Wave-Mixing (FWM) background generated within the fiber and integrated it into a fiber based scanning probe head of a few millimeters in diameter. The DCF includes a large mode area (LMA) core as a first means of reducing FWM generation by ~3 dB compared to commercially available, step-index single mode fibers. A micro-fabricated miniature optical filter (MOF) was grown on the distal end of the DCF to block the remaining FWM background from reaching the sample. The resulting probe was used to demonstrate high contrast images of polystyrene beads in the forward-CARS configuration with > 10 dB suppression of the FWM background. In epi-CARS geometry, images exhibited lower contrast due to the leakage of MOF-reflected FWM from the fiber core. Improvements concepts for the fiber probe are proposed for high contrast epi-CARS imaging to enable endoscopic implementation in clinical tissue assessment contexts, particularly in the early detection of endoluminal cancers and in tumor margin assessment. PMID:25401538

  15. Recent Advances in Cardiac Computed Tomography: Dual Energy, Spectral and Molecular CT Imaging

    PubMed Central

    Danad, Ibrahim; Fayad, Zahi A.; Willemink, Martin J.; Min, James K.

    2015-01-01

    Computed tomography (CT) evolved into a powerful diagnostic tool and it is impossible to imagine current clinical practice without CT imaging. Due to its widespread availability, ease of clinical application, superb sensitivity for detection of CAD, and non-invasive nature, CT has become a valuable tool within the armamentarium of the cardiologist. In the last few years, numerous technological advances in CT have occurred—including dual energy CT (DECT), spectral CT and CT-based molecular imaging. By harnessing the advances in technology, cardiac CT has advanced beyond the mere evaluation of coronary stenosis to an imaging modality tool that permits accurate plaque characterization, assessment of myocardial perfusion and even probing of molecular processes that are involved in coronary atherosclerosis. Novel innovations in CT contrast agents and pre-clinical spectral CT devices have paved the way for CT-based molecular imaging. PMID:26068288

  16. Neuroimaging of pediatric brain tumors: from basic to advanced magnetic resonance imaging (MRI).

    PubMed

    Panigrahy, Ashok; Blüml, Stefan

    2009-11-01

    In this review, the basic magnetic resonance concepts used in the imaging approach of a pediatric brain tumor are described with respect to different factors including understanding the significance of the patient's age. Also discussed are other factors directly related to the magnetic resonance scan itself including evaluating the location of the tumor, determining if the lesion is extra-axial or intra-axial, and evaluating the contrast characteristics of the lesion. Of note, there are key imaging features of pediatric brain tumors, which can give information about the cellularity of the lesion, which can then be confirmed with advanced magnetic resonance imaging (MRI) techniques. The second part of this review will provide an overview of the major advanced MRI techniques used in pediatric imaging, particularly, magnetic resonance diffusion, magnetic resonance spectroscopy, and magnetic resonance perfusion. The last part of the review will provide more specific information about the use of advanced magnetic resonance techniques in the evaluation of pediatric brain tumors.

  17. Conventional and advanced MR imaging in infantile Refsum disease.

    PubMed

    Kılıç, Mustafa; Karlı-Oğuz, Kader; Haliloğlu, Göknur; Topçu, Meral; Wanders, Ronald James; Coşkun, Turgay

    2015-01-01

    We report magnetic resonance (MR) imaging findings including diffusion-weighted imaging and proton MR spectroscopy findings in a patient with infantile Refsum disease. The initial diagnosis was made on the basis of history, clinical findings and biochemical studies. Bilateral and symmetrical involvement of the peritrigonal white matter, centrum semiovale, thalami, corpus callosum and corticospinal tracts as assessed by increased T2 signal was highly suggestive of a peroxisomal disorder. Facilitated diffusion was observed in diseased parenchyma. Long echo-time (TE: 270 ms) MRS showed decreased N-acetyl-aspartate/creatine and elevated choline/creatine and lactate; short echo-time MRS (TE: 30 ms) revealed increased myoinositol at 3.56 ppm and lipid peaks at 0.9 and 1.3 ppm. A major contribution to the differential diagnosis came from MR imaging and proton MRS, as discussed in this report.

  18. Advances in MR Imaging for Cervical Spondylotic Myelopathy

    PubMed Central

    Ellingson, Benjamin M.; Salamon, Noriko; Holly, Langston T.

    2016-01-01

    Cervical spondylosis is the most common cause of nontraumatic spinal cord injury and is the most common cause of spinal cord dysfunction in the elderly. Magnetic resonance imaging (MRI) is an invaluable tool for the diagnosis and assessment of cervical spondylosis due to its sensitivity to soft tissues; however, standard MR techniques have some limitations in predicting neurological impairment and response to intervention. Therefore, there is great interest in novel MR techniques including diffusion tensor imaging (DTI) and MR spectroscopy (MRS) as imaging biomarkers for neurological impairment and tools for understanding spinal cord physiology. This review outlines the pathogenesis of cervical spondylotic myelopathy (CSM), the correlative abnormalities observed on standard MRI, the biological implications and current status of DTI and MRS as clinical tools, and future directions of MR technology in the management of CSM patients. PMID:23917647

  19. Advances in imaging for diagnosis and management of cardiac sarcoidosis.

    PubMed

    Aggarwal, Niti R; Snipelisky, David; Young, Phillip M; Gersh, Bernard J; Cooper, Leslie T; Chareonthaitawee, Panithaya

    2015-09-01

    Sarcoidosis is a multisystem granulomatous disorder with a high prevalence of cardiac involvement. Cardiac sarcoidosis (CS) may be life threatening due to end-stage cardiomyopathy and sudden cardiac death. The frequent absence of specific symptoms and lack of a diagnostic 'gold standard' pose challenges in the diagnosis of CS. Endomyocardial biopsy, although specific, has an unacceptably low sensitivity. Non-invasive cardiac imaging has a huge role in the assessment of patients with known or suspected CS. This comprehensive review compares the diagnostic accuracy, along with advantages and disadvantages, of established and emerging imaging modalities for CS.

  20. Advancements in MR Imaging of the Prostate: From Diagnosis to Interventions

    PubMed Central

    Bonekamp, David; Jacobs, Michael A.; El-Khouli, Riham; Stoianovici, Dan

    2011-01-01

    Prostate cancer is the most frequently diagnosed cancer in males and the second leading cause of cancer-related death in men. Assessment of prostate cancer can be divided into detection, localization, and staging; accurate assessment is a prerequisite for optimal clinical management and therapy selection. Magnetic resonance (MR) imaging has been shown to be of particular help in localization and staging of prostate cancer. Traditional prostate MR imaging has been based on morphologic imaging with standard T1-weighted and T2-weighted sequences, which has limited accuracy. Recent advances include additional functional and physiologic MR imaging techniques (diffusion-weighted imaging, MR spectroscopy, and perfusion imaging), which allow extension of the obtainable information beyond anatomic assessment. Multiparametric MR imaging provides the highest accuracy in diagnosis and staging of prostate cancer. In addition, improvements in MR imaging hardware and software (3-T vs 1.5-T imaging) continue to improve spatial and temporal resolution and the signal-to-noise ratio of MR imaging examinations. Another recent advancement in the field is MR imaging guidance for targeted prostate biopsy, which is an alternative to the current standard of transrectal ultrasonography–guided systematic biopsy. © RSNA, 2011 PMID:21571651

  1. Advanced InSAR imaging for dune mapping

    NASA Astrophysics Data System (ADS)

    Havivi, Shiran; August, Yitzhak; Blumberg, Dan G.; Rotman, Stanley R.

    2015-04-01

    Aeolian morphologies are formed in the presence of sufficient wind energy and available particles. These processes occur naturally or are further enhanced or reduced by human intervention. The dimensions of change are dependent primarily on the wind energy and surface properties. Since the 1970's, remote sensing imagery both optical and radar, are used for documentation and interpretation of the geomorphologic changes of sand dunes. Remote sensing studies of Aeolian morphologies is mostly useful to document major changes, yet, subtle changes, occurring in a period of days or months in scales of centimeters, are very difficult to detect in imagery. Interferometric Synthetic Aperture Radar (InSAR) is an imaging technique for measuring Earth's surface topography and deformation. InSAR images are produced by measuring the radar phase difference between two separated antennas that view the same surface area. Classical InSAR is based on high coherence between two images or more. The output (interferogram) can show subtle changes with an accuracy of several millimeters to centimeters. Very little work has been done on measuring or identifying the changes in dunes using InSAR. The reason is that dunes tend to be less coherent than firm, stable, surfaces. This research aims to demonstrate how interferometric decorrelation, or, coherence change detection, can be used for identifying dune instability. We hypothesize and demonstrate that the loss of radar coherence over time on dunes can be used as an indication of the dune's instability. When SAR images are acquired at sufficiently close intervals one can measure the time it takes to lose coherence and associate this time with geomorphic stability. To achieve our goals, the Nitzanim coastal dunes along the Mediterranean, 40 km south of Tel-Aviv, Israel, were chosen as a case study. The dunes in this area are of varying levels of stability and vegetation cover and have been monitored meteorologically, geomorphologically and

  2. A Review of Significant Advances in Neutron Imaging from Conception to the Present

    NASA Astrophysics Data System (ADS)

    Brenizer, J. S.

    This review summarizes the history of neutron imaging with a focus on the significant events and technical advancements in neutron imaging methods, from the first radiograph to more recent imaging methods. A timeline is presented to illustrate the key accomplishments that advanced the neutron imaging technique. Only three years after the discovery of the neutron by English physicist James Chadwick in 1932, neutron imaging began with the work of Hartmut Kallmann and Ernst Kuhn in Berlin, Germany, from 1935-1944. Kallmann and Kuhn were awarded a joint US Patent issued in January 1940. Little progress was made until the mid-1950's when Thewlis utilized a neutron beam from the BEPO reactor at Harwell, marking the beginning of the application of neutron imaging to practical applications. As the film method was improved, imaging moved from a qualitative to a quantitative technique, with applications in industry and in nuclear fuels. Standards were developed to aid in the quantification of the neutron images and the facility's capabilities. The introduction of dynamic neutron imaging (initially called real-time neutron radiography and neutron television) in the late 1970's opened the door to new opportunities and new challenges. As the electronic imaging matured, the introduction of the CCD imaging devices and solid-state light intensifiers helped address some of these challenges. Development of improved imaging devices for the medical community has had a major impact on neutron imaging. Additionally, amorphous silicon sensors provided improvements in temporal resolution, while providing a reasonably large imaging area. The development of new neutron imaging sensors and the development of new neutron imaging techniques in the past decade has advanced the technique's ability to provide insight and understanding of problems that other non-destructive techniques could not provide. This rapid increase in capability and application would not have been possible without the

  3. Advances in photographic X-ray imaging for solar astronomy

    NASA Astrophysics Data System (ADS)

    Moses, D.; Schueller, R.; Waljeski, K.; Davis, J. M.

    1989-11-01

    The technique of obtaining quantitative data from high resolution soft X-ray photographic images produced by grazing incidence optics was successfully developed to a high degree during the AS&E Solar Research Sounding Rocket Program and the S-054 X-Ray Spectrographic Telescope Experiment Program on Skylab. Continued use of soft X-Ray photographic imaging in sounding rocket flights of the AS&E High Resolution Solar Soft X-Ray Imaging Payload has provided opportunities to further develop these techniques. The developments discussed include: (1) the calibration and use of an inexpensive, commercially available microprocessor controlled drum type film processor for photometric film development, (2) the use of Kodak Technical Pan 2415 film and Kodak SO-253 High Speed Holographic film for improved resolution, and (3) the application of a technique described by Cook, Ewing, and Sutton (1988) for determining the film characteristics curves from density histograms of the flight film. Although the superior sensitivity, noise level, and linearity of microchannel plate and CCD detectors attracts the development efforts of many groups working in soft X-ray imaging, the high spatial resolution and dynamic range as well as the reliability and ease of application of photographic media assures the continued use of these techniques in solar X-ray astronomy observations.

  4. Advances in photographic X-ray imaging for solar astronomy

    NASA Astrophysics Data System (ADS)

    Moses, J. Daniel; Schueller, R.; Waljeski, K.; Davis, John M.

    1989-08-01

    The technique of obtaining quantitative data from high resolution soft X-ray photographic images produced by grazing incidence optics was successfully developed to a high degree during the Solar Research Sounding Rocket Program and the S-054 X-Ray Spectrographic Telescope Experiment Program on Skylab. Continued use of soft X-ray photographic imaging in sounding rocket flights of the High Resolution Solar Soft X-Ray Imaging Payload has provided opportunities to further develop these techniques. The developments discussed include: (1) The calibration and use of an inexpensive, commercially available microprocessor controlled drum type film processor for photometric film development; (2) The use of Kodak Technical Pan 2415 film and Kodak SO-253 High Speed Holographic film for improved resolution; and (3) The application of a technique described by Cook, Ewing, and Sutton for determining the film characteristics curves from density histograms of the flight film. Although the superior sensitivity, noise level, and linearity of microchannel plate and CCD detectors attracts the development efforts of many groups working in soft X-ray imaging, the high spatial resolution and dynamic range as well as the reliability and ease of application of photographic media assures the continued use of these techniques in solar X-ray astronomy observations.

  5. Advanced scanners and imaging systems for earth observations. [conferences

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Assessments of present and future sensors and sensor related technology are reported along with a description of user needs and applications. Five areas are outlined: (1) electromechanical scanners, (2) self-scanned solid state sensors, (3) electron beam imagers, (4) sensor related technology, and (5) user applications. Recommendations, charts, system designs, technical approaches, and bibliographies are included for each area.

  6. In situ metabolomic mass spectrometry imaging: recent advances and difficulties.

    PubMed

    Miura, Daisuke; Fujimura, Yoshinori; Wariishi, Hiroyuki

    2012-08-30

    MS imaging (MSI) is a remarkable new technology that enables us to determine the distribution of biological molecules present in tissue sections by direct ionization and detection. This technique is now widely used for in situ imaging of endogenous or exogenous molecules such as proteins, lipids, drugs and their metabolites, and it is a potential tool for pathological analysis and the investigation of disease mechanisms. MSI is also thought to be a technique that could be used for biomarker discovery with spatial information. The application of MSI to the study of endogenous metabolites has received considerable attention because metabolites are the result of the interactions of a system's genome with its environment and a total set of these metabolites more closely represents the phenotype of an organism under a given set of conditions. Recent studies have suggested the importance of in situ metabolite imaging in biological discovery and biomedical applications, but several issues regarding the technical application limits of MSI still remained to be resolved. In this review, we describe the capabilities of the latest MSI techniques for the imaging of endogenous metabolites in biological samples, and also discuss the technical problems and new challenges that need to be addressed for effective and widespread application of MSI in both preclinical and clinical settings.

  7. Perspectives on Imaging: Advanced Applications. Introduction and Overview.

    ERIC Educational Resources Information Center

    Lynch, Clifford A.; Lunin, Lois F.

    1991-01-01

    Provides an overview of six articles that address relationships between electronic imaging technology and information science. Articles discuss the areas of technology; applications in the fields of visual arts, medicine, and textile history; conceptual foundations; and future visions, including work in virtual reality and cyberspace. (LRW)

  8. Fabry-Perot MEMS Accelerometers for Advanced Seismic Imaging

    SciTech Connect

    Chisum, Brad

    2015-05-31

    This report summarizes the technical achievements that occurred over the duration of the project. On November 14th, 2014, Lumedyne Technologies Incorporated was acquired. As a result of the acquisition, the work toward seismic imaging applications was suspended indefinitely. This report captures the progress achieved up to that time.

  9. Advanced Computer Image Generation Techniques Exploiting Perceptual Characteristics. Final Report.

    ERIC Educational Resources Information Center

    Stenger, Anthony J.; And Others

    This study suggests and identifies computer image generation (CIG) algorithms for visual simulation that improve the training effectiveness of CIG simulators and identifies areas of basic research in visual perception that are significant for improving CIG technology. The first phase of the project entailed observing three existing CIG simulators.…

  10. Update on advanced imaging options for thyroid-associated orbitopathy

    PubMed Central

    Rabinowitz, Michael P.; Carrasco, Jacqueline R.

    2012-01-01

    Thyroid-associated orbitopathy (TAO) is a diverse spectrum of signs and symptoms that appears to have immunologic and pathologic causative factors as diverse as its clinical presentations. Lymphocytes, hormones, and cytokines affect orbital fibroblasts and other similar cells, which exert their effects on orbital tissues, including the extraocular muscles, orbital fat, and optic nerve. This complicated inflammatory cascade and the myriad of clinical findings that result contributes to the active phase of TAO. The distinction between the active and inactive phases of TAO is an important one, as the proper treatment will depend on the disease phase and degree thereof. Several clinical grading scales and scores have been established to help qualify and quantify the disease severity. Aiding clinical exam and acumen, proper and reproducible imaging of the orbit and ocular adnexa is incredibly important to the management of TAO. Orbital ultrasound, computed tomography, magnetic resonance imaging, and scintigraphy each have unique abilities, including quantifying orbital changes, assessing disease activity, correlating orbital findings with clinical changes, guiding appropriate treatment, and monitoring therapeutic responses. Further, study ease, accessibility, cost, sensitivity, specificity, reproducibility, and risks are all important considerations in picking the right test with which to diagnose and follow TAO. This analysis will provide a review of orbital imaging for TAO, including the mechanism of each imaging technique as well as their rationales, advantages, disadvantages, and utilities. PMID:23961023

  11. X-ray imaging in advanced studies of ophthalmic diseases

    SciTech Connect

    Antunes, Andrea; Safatle, Angelica M. V.; Barros, Paulo S. M.; Morelhao, Sergio L.

    2006-07-15

    Microscopic characterization of pathological tissues has one major intrinsic limitation, the small sampling areas with respect to the extension of the tissues. Mapping possible changes on vast tissues and correlating them with large ensembles of clinical cases is not a feasible procedure for studying most diseases, as for instance vision loss related diseases and, in particular, the cataract. Although intraocular lens implants are successful treatments, cataract still is a leading public-health issue that grows in importance as the population increases and life expectancy is extended worldwide. In this work we have exploited the radiation-tissue interaction properties of hard x-rays--very low absorption and scattering--to map distinct lesions on entire eye lenses. At the used synchrotron x-ray photon energy of 20 keV (wavelength {lambda}=0.062 nm), scattering and refraction are angular resolved effects. It allows the employed x-ray image technique to efficiently characterize two types of lesions in eye lenses under cataractogenesis: distributions of tiny scattering centers and extended areas of fiber cell compaction. The data collection procedure is relatively fast; allowing dozens of samples to be totally imaged (scattering, refraction, and mass absorption images) in a single day of synchrotron beam time. More than 60 cases of canine cataract, not correlated to specific causes, were investigated in this first application of x-rays to image entire lenses. Cortical opacity cases, or partial opacity, could be related to the presence of calcificated tissues at the cortical areas, clearly visible in the images, whose elemental contents were verified by micro x-ray fluorescence as very rich in calcium. Calcificated tissues were also observed at nuclear areas in some cases of hypermature cataract. Total opacity cases without distinguishable amount of scattering centers consist in 70% of the analyzed cases, where remarkable fissure marks owing to extended areas of fiber

  12. X-ray imaging in advanced studies of ophthalmic diseases.

    PubMed

    Antunes, Andrea; Safatle, Angélica M V; Barros, Paulo S M; Morelhão, Sérgio L

    2006-07-01

    Microscopic characterization of pathological tissues has one major intrinsic limitation, the small sampling areas with respect to the extension of the tissues. Mapping possible changes on vast tissues and correlating them with large ensembles of clinical cases is not a feasible procedure for studying most diseases, as for instance vision loss related diseases and, in particular, the cataract. Although intraocular lens implants are successful treatments, cataract still is a leading public-health issue that grows in importance as the population increases and life expectancy is extended worldwide. In this work we have exploited the radiation-tissue interaction properties of hard x-rays--very low absorption and scattering--to map distinct lesions on entire eye lenses. At the used synchrotron x-ray photon energy of 20 keV (wavelength lambda=0.062 nm), scattering and refraction are angular resolved effects. It allows the employed x-ray image technique to efficiently characterize two types of lesions in eye lenses under cataractogenesis: distributions of tiny scattering centers and extended areas of fiber cell compaction. The data collection procedure is relatively fast; allowing dozens of samples to be totally imaged (scattering, refraction, and mass absorption images) in a single day of synchrotron beam time. More than 60 cases of canine cataract, not correlated to specific causes, were investigated in this first application of x-rays to image entire lenses. Cortical opacity cases, or partial opacity, could be related to the presence of calcificated tissues at the cortical areas, clearly visible in the images, whose elemental contents were verified by micro x-ray fluorescence as very rich in calcium. Calcificated tissues were also observed at nuclear areas in some cases of hypermature cataract. Total opacity cases without distinguishable amount of scattering centers consist in 70% of the analyzed cases, where remarkable fissure marks owing to extended areas of fiber

  13. A coming of age: advanced imaging technologies for characterising the developing mouse.

    PubMed

    Norris, Francesca C; Wong, Michael D; Greene, Nicholas D E; Scambler, Peter J; Weaver, Tom; Weninger, Wolfgang J; Mohun, Timothy J; Henkelman, R Mark; Lythgoe, Mark F

    2013-12-01

    The immense challenge of annotating the entire mouse genome has stimulated the development of cutting-edge imaging technologies in a drive for novel information. These techniques promise to improve understanding of the genes involved in embryo development, at least one third of which have been shown to be essential. Aligning advanced imaging technologies with biological needs will be fundamental to maximising the number of phenotypes discovered in the coming years. International efforts are underway to meet this challenge through an integrated and sophisticated approach to embryo phenotyping. We review rapid advances made in the imaging field over the past decade and provide a comprehensive examination of the relative merits of current and emerging techniques. The aim of this review is to provide a guide to state-of-the-art embryo imaging that will enable informed decisions as to which technology to use and fuel conversations between expert imaging laboratories, researchers, and core mouse production facilities.

  14. Advancing molecular imaging: a chairman's perspective on how radiology can meet the challenge.

    PubMed

    Hricak, Hedvig

    2011-02-01

    To date, most molecular imaging techniques applied clinically have offered relatively general information about the metabolism and physiology of diseased cells and tissues. However, due to recent scientific and technological advances, much more specifically targeted molecular imaging probes (e.g., reporter gene probes, whole cell-tracking probes, and probes for localizing specific biomolecules) are now being used in preclinical research and, in some cases, translated to the clinical setting. As a result, the imaging community is poised to help lead a revolution in personalized, molecularly targeted medicine. This article considers the importance of molecular imaging for advancing research and clinical care both within individual institutions and across the medical field. It outlines specific steps that leaders in academic radiology can take to hasten progress in molecular imaging and explains why they must have the courage to reach across traditional interdisciplinary boundaries and advocate for major investments in equipment, education, and personnel. PMID:20809095

  15. Multifunctional nanomaterials for advanced molecular imaging and cancer therapy

    NASA Astrophysics Data System (ADS)

    Subramaniam, Prasad

    Nanotechnology offers tremendous potential for use in biomedical applications, including cancer and stem cell imaging, disease diagnosis and drug delivery. The development of nanosystems has aided in understanding the molecular mechanisms of many diseases and permitted the controlled nanoscale manipulation of biological phenomena. In recent years, many studies have focused on the use of several kinds of nanomaterials for cancer and stem cell imaging and also for the delivery of anticancer therapeutics to tumor cells. However, the proper diagnosis and treatment of aggressive tumors such as brain and breast cancer requires highly sensitive diagnostic agents, in addition to the ability to deliver multiple therapeutics using a single platform to the target cells. Addressing these challenges, novel multifunctional nanomaterial-based platforms that incorporate multiple therapeutic and diagnostic agents, with superior molecular imaging and targeting capabilities, has been presented in this work. The initial part of this work presents the development of novel nanomaterials with superior optical properties for efficiently delivering soluble cues such as small interfering RNA (siRNA) into brain cancer cells with minimal toxicity. Specifically, this section details the development of non-toxic quantums dots for the imaging and delivery of siRNA into brain cancer and mesenchymal stem cells, with the hope of using these quantum dots as multiplexed imaging and delivery vehicles. The use of these quantum dots could overcome the toxicity issues associated with the use of conventional quantum dots, enabled the imaging of brain cancer and stem cells with high efficiency and allowed for the delivery of siRNA to knockdown the target oncogene in brain cancer cells. The latter part of this thesis details the development of nanomaterial-based drug delivery platforms for the co-delivery of multiple anticancer drugs to brain tumor cells. In particular, this part of the thesis focuses on

  16. Pulse laser imaging amplifier for advanced ladar systems

    NASA Astrophysics Data System (ADS)

    Khizhnyak, Anatoliy; Markov, Vladimir; Tomov, Ivan; Murrell, David

    2016-05-01

    Security measures sometimes require persistent surveillance of government, military and public areas Borders, bridges, sport arenas, airports and others are often surveilled with low-cost cameras. Their low-light performance can be enhanced with laser illuminators; however various operational scenarios may require a low-intensity laser illumination with the object-scattered light intensity lower than the sensitivity of the Ladar image detector. This paper discusses a novel type of high-gain optical image amplifier. The approach enables time-synchronization of the incoming and amplifying signals with accuracy <= 1 ns. The technique allows the incoming signal to be amplified without the need to match the input spectrum to the cavity modes. Instead, the incoming signal is accepted within the spectral band of the amplifier. We have gauged experimentally the performance of the amplifier with a 40 dB gain and an angle of view 20 mrad.

  17. Advanced synchronous luminescence imaging for chemical and medical diagnostics

    DOEpatents

    Vo-Dinh, Tuan

    2006-09-05

    A diagnostic method and associated system includes the steps of exposing at least one sample location with excitation radiation through a single optical waveguide or a single optical waveguide bundle, wherein the sample emits emission radiation in response to the excitation radiation. The same single optical waveguide or the single optical waveguide bundle receives at least a portion of the emission radiation from the sample, thus providing co-registration of the excitation radiation and the emission radiation. The wavelength of the excitation radiation and emission radiation is synchronously scanned to produce a spectrum upon which an image can be formed. An increased emission signal is generated by the enhanced overlap of the excitation and emission focal volumes provided by co-registration of the excitation and emission signals thus increasing the sensitivity as well as decreasing the exposure time necessary to obtain an image.

  18. Advances in nanoparticle imaging technology for vascular pathologies.

    PubMed

    Annapragada, Ananth

    2015-01-01

    Nanoparticle imaging agents for vascular pathologies are in development, and some agents are already in clinical trials. Untargeted agents, with long circulation, are excellent blood-pool agents, but molecularly targeted agents have significant advantages due to the signal enhancement possible with nanoparticle presentation of the contrast agent molecules. Molecular targets that are accessible directly from the vasculature are optimal for such agents. Targets that are removed from the vasculature, such as those on tumor cell surfaces, have limited accessibility owing to the enhanced permeation and retention effect. Yet, efforts at molecular targeting have tested small molecules, peptides, antibodies, and most recently aptamers as possible targeting ligands. The future is bright for nanoparticle-based imaging of vascular pathologies.

  19. Advances in imaging to allow personalized medicine in Crohn's disease.

    PubMed

    Neurath, Markus F

    2015-08-01

    Crohn's disease is a destructive inflammatory bowel disease of unknown origin that may lead to various complications such as strictures, stenosis, fistulas and colitis-associated neoplasias. However, the course of the disease varies substantially among patients and disease behaviour may also change with time. At diagnosis behaviour is inflammatory in the majority of patients, while penetrating or structuring behaviour become more prominent at later time points. Thus, medication in Crohn's disease needs frequent optimization over time. Therefore, new strategies for prediction of response to therapy are urgently needed. Here, recent advantages in imaging techniques for personalized medicine in Crohn's disease are reviewed. Such advantages include ultrasonography, computed tomography, magnetic resonance imaging and new endoscopic approaches such as molecular endoscopy. It is expected that these novel techniques will lead to marked improvements in the assessment of disease behaviour and the prediction of response to clinical therapy with biologicals. PMID:26002559

  20. Recent Advances in Molecular Image-Guided Cancer Radionuclide Therapy.

    PubMed

    Gao, Duo; Sun, Xianlei; Gao, Liquan; Liu, Zhaofei

    2015-01-01

    Cancer-targeted radionuclide therapy is a promising approach for the treatment of a wide variety of malignancies, especially those resistant to conventional therapies. However, to improve the use of targeted radionuclide therapy for the management of cancer patients, the in vivo behaviors, dosimetry, and efficacy of radiotherapeutic agents need to be well characterized and monitored. Molecular imaging, which is a powerful tool for the noninvasive characterization and quantification of biological processes in living subjects at the cellular and molecular levels, plays an important role in the guidance of cancer radionuclide therapy. In this review, we introduce the radiotherapeutics for cancer-targeted therapy and summarize the most recent evidence supporting the use of molecular imaging to guide cancer radionuclide therapy.

  1. Advances in imaging technologies for planning breast reconstruction

    PubMed Central

    Mohan, Anita T.

    2016-01-01

    The role and choice of preoperative imaging for planning in breast reconstruction is still a disputed topic in the reconstructive community, with varying opinion on the necessity, the ideal imaging modality, costs and impact on patient outcomes. Since the advent of perforator flaps their use in microsurgical breast reconstruction has grown. Perforator based flaps afford lower donor morbidity by sparing the underlying muscle provide durable results, superior cosmesis to create a natural looking new breast, and are preferred in the context of radiation therapy. However these surgeries are complex; more technically challenging that implant based reconstruction, and leaves little room for error. The role of imaging in breast reconstruction can assist the surgeon in exploring or confirming flap choices based on donor site characteristics and presence of suitable perforators. Vascular anatomical studies in the lab have provided the surgeon a foundation of knowledge on location and vascular territories of individual perforators to improve our understanding for flap design and safe flap harvest. The creation of a presurgical map in patients can highlight any abnormal or individual anatomical variance to optimize flap design, intraoperative decision-making and execution of flap harvest with greater predictability and efficiency. This article highlights the role and techniques for preoperative planning using the newer technologies that have been adopted in reconstructive clinical practice: computed tomographic angiography (CTA), magnetic resonance angiography (MRA), laser-assisted indocyanine green fluorescence angiography (LA-ICGFA) and dynamic infrared thermography (DIRT). The primary focus of this paper is on the application of CTA and MRA imaging modalities. PMID:27047790

  2. Value of nuclear bone imaging in advanced prostatic cancer

    SciTech Connect

    Pollen, J.J.; Gerber, K.; Ashburn, W.L.; Schmidt, J.D.

    1981-02-01

    The nuclear bone scan is a highly sensitive means of detecting skeletal metastasis in patients with prostatic cancer. Serial bone imaging provides an accurate method to follow the response of osseous metastases to treatment and to detect relapsing disease in the skeleton. In selected instances the nuclear bone scan can provide information about vertebral metastases that can be important for planning palliative treatment of pain.

  3. Advances in imaging technologies for planning breast reconstruction.

    PubMed

    Mohan, Anita T; Saint-Cyr, Michel

    2016-04-01

    The role and choice of preoperative imaging for planning in breast reconstruction is still a disputed topic in the reconstructive community, with varying opinion on the necessity, the ideal imaging modality, costs and impact on patient outcomes. Since the advent of perforator flaps their use in microsurgical breast reconstruction has grown. Perforator based flaps afford lower donor morbidity by sparing the underlying muscle provide durable results, superior cosmesis to create a natural looking new breast, and are preferred in the context of radiation therapy. However these surgeries are complex; more technically challenging that implant based reconstruction, and leaves little room for error. The role of imaging in breast reconstruction can assist the surgeon in exploring or confirming flap choices based on donor site characteristics and presence of suitable perforators. Vascular anatomical studies in the lab have provided the surgeon a foundation of knowledge on location and vascular territories of individual perforators to improve our understanding for flap design and safe flap harvest. The creation of a presurgical map in patients can highlight any abnormal or individual anatomical variance to optimize flap design, intraoperative decision-making and execution of flap harvest with greater predictability and efficiency. This article highlights the role and techniques for preoperative planning using the newer technologies that have been adopted in reconstructive clinical practice: computed tomographic angiography (CTA), magnetic resonance angiography (MRA), laser-assisted indocyanine green fluorescence angiography (LA-ICGFA) and dynamic infrared thermography (DIRT). The primary focus of this paper is on the application of CTA and MRA imaging modalities. PMID:27047790

  4. Advanced imaging of the macrostructure and microstructure of bone

    NASA Technical Reports Server (NTRS)

    Genant, H. K.; Gordon, C.; Jiang, Y.; Link, T. M.; Hans, D.; Majumdar, S.; Lang, T. F.

    2000-01-01

    Noninvasive and/or nondestructive techniques are capable of providing more macro- or microstructural information about bone than standard bone densitometry. Although the latter provides important information about osteoporotic fracture risk, numerous studies indicate that bone strength is only partially explained by bone mineral density. Quantitative assessment of macro- and microstructural features may improve our ability to estimate bone strength. The methods available for quantitatively assessing macrostructure include (besides conventional radiographs) quantitative computed tomography (QCT) and volumetric quantitative computed tomography (vQCT). Methods for assessing microstructure of trabecular bone noninvasively and/or nondestructively include high-resolution computed tomography (hrCT), micro-computed tomography (muCT), high-resolution magnetic resonance (hrMR), and micromagnetic resonance (muMR). vQCT, hrCT and hrMR are generally applicable in vivo; muCT and muMR are principally applicable in vitro. Although considerable progress has been made in the noninvasive and/or nondestructive imaging of the macro- and microstructure of bone, considerable challenges and dilemmas remain. From a technical perspective, the balance between spatial resolution versus sampling size, or between signal-to-noise versus radiation dose or acquisition time, needs further consideration, as do the trade-offs between the complexity and expense of equipment and the availability and accessibility of the methods. The relative merits of in vitro imaging and its ultrahigh resolution but invasiveness versus those of in vivo imaging and its modest resolution but noninvasiveness also deserve careful attention. From a clinical perspective, the challenges for bone imaging include balancing the relative advantages of simple bone densitometry against the more complex architectural features of bone or, similarly, the deeper research requirements against the broader clinical needs. The

  5. Magnetic particle imaging: advancements and perspectives for real-time in vivo monitoring and image-guided therapy

    NASA Astrophysics Data System (ADS)

    Pablico-Lansigan, Michele H.; Situ, Shu F.; Samia, Anna Cristina S.

    2013-05-01

    Magnetic particle imaging (MPI) is an emerging biomedical imaging technology that allows the direct quantitative mapping of the spatial distribution of superparamagnetic iron oxide nanoparticles. MPI's increased sensitivity and short image acquisition times foster the creation of tomographic images with high temporal and spatial resolution. The contrast and sensitivity of MPI is envisioned to transcend those of other medical imaging modalities presently used, such as magnetic resonance imaging (MRI), X-ray scans, ultrasound, computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT). In this review, we present an overview of the recent advances in the rapidly developing field of MPI. We begin with a basic introduction of the fundamentals of MPI, followed by some highlights over the past decade of the evolution of strategies and approaches used to improve this new imaging technique. We also examine the optimization of iron oxide nanoparticle tracers used for imaging, underscoring the importance of size homogeneity and surface engineering. Finally, we present some future research directions for MPI, emphasizing the novel and exciting opportunities that it offers as an important tool for real-time in vivo monitoring. All these opportunities and capabilities that MPI presents are now seen as potential breakthrough innovations in timely disease diagnosis, implant monitoring, and image-guided therapeutics.

  6. Advanced human machine interaction for an image interpretation workstation

    NASA Astrophysics Data System (ADS)

    Maier, S.; Martin, M.; van de Camp, F.; Peinsipp-Byma, E.; Beyerer, J.

    2016-05-01

    In recent years, many new interaction technologies have been developed that enhance the usability of computer systems and allow for novel types of interaction. The areas of application for these technologies have mostly been in gaming and entertainment. However, in professional environments, there are especially demanding tasks that would greatly benefit from improved human machine interfaces as well as an overall improved user experience. We, therefore, envisioned and built an image-interpretation-workstation of the future, a multi-monitor workplace comprised of four screens. Each screen is dedicated to a complex software product such as a geo-information system to provide geographic context, an image annotation tool, software to generate standardized reports and a tool to aid in the identification of objects. Using self-developed systems for hand tracking, pointing gestures and head pose estimation in addition to touchscreens, face identification, and speech recognition systems we created a novel approach to this complex task. For example, head pose information is used to save the position of the mouse cursor on the currently focused screen and to restore it as soon as the same screen is focused again while hand gestures allow for intuitive manipulation of 3d objects in mid-air. While the primary focus is on the task of image interpretation, all of the technologies involved provide generic ways of efficiently interacting with a multi-screen setup and could be utilized in other fields as well. In preliminary experiments, we received promising feedback from users in the military and started to tailor the functionality to their needs

  7. Advanced imaging microscope tools applied to microgravity research investigations

    NASA Astrophysics Data System (ADS)

    Peterson, L.; Samson, J.; Conrad, D.; Clark, K.

    1998-01-01

    The inability to observe and interact with experiments on orbit has been an impediment for both basic research and commercial ventures using the shuttle. In order to open the frontiers of space, the Center for Microgravity Automation Technology has developed a unique and innovative system for conducting experiments at a distance, the ``Remote Scientist.'' The Remote Scientist extends laboratory automation capability to the microgravity environment. While the Remote Scientist conceptually encompasses a broad spectrum of elements and functionalities, the development approach taken is to: • establish a baseline capability that is both flexible and versatile • incrementally augment the baseline with additional functions over time. Since last year, the application of the Remote Scientist has changed from protein crystal growth to tissue culture, specifically, the development of skeletal muscle under varying levels of tension. This system includes a series of bioreactor chambers that allow for three-dimensional growth of muscle tissue on a membrane suspended between the two ends of a programmable force transducer that can provide automated or investigator-initiated tension on the developing tissue. A microscope objective mounted on a translation carriage allows for high-resolution microscopy along a large area of the tissue. These images will be mosaiced on orbit to detect features and structures that span multiple images. The use of fluorescence and pseudo-confocal microscopy will maximize the observational capabilities of this system. A series of ground-based experiments have been performed to validate the bioreactor, the force transducer, the translation carriage and the image acquisition capabilities of the Remote Scientist. • The bioreactor is capable of sustaining three dimensional tissue culture growth over time. • The force transducer can be programmed to provide static tension on cells or to simulate either slow or fast growth of underlying tissues in

  8. Advanced Thermal Emission Imaging Systems Definition and Development

    NASA Technical Reports Server (NTRS)

    Blasius, Karl; Nava, David (Technical Monitor)

    2002-01-01

    Santa Barbara Remote Sensing (SBRS), Raytheon Company, is pleased to submit this quarterly progress report of the work performed in the third quarter of Year 2 of the Advanced THEMIS Project, July through September 2002. We review here progress in the proposed tasks. During July through September 2002 progress was made in two major tasks, Spectral Response Characterization and Flight Instrument Definition. Because of staffing problems and technical problems earlier in the program we have refocused the remaining time and budget on the key technical tasks. Current technical problems with a central piece of test equipment has lead us to request a 1 quarter extension to the period of performance. This request is being made through a separate letter independent of this report.

  9. INVITED REVIEW--IMAGE REGISTRATION IN VETERINARY RADIATION ONCOLOGY: INDICATIONS, IMPLICATIONS, AND FUTURE ADVANCES.

    PubMed

    Feng, Yang; Lawrence, Jessica; Cheng, Kun; Montgomery, Dean; Forrest, Lisa; Mclaren, Duncan B; McLaughlin, Stephen; Argyle, David J; Nailon, William H

    2016-01-01

    The field of veterinary radiation therapy (RT) has gained substantial momentum in recent decades with significant advances in conformal treatment planning, image-guided radiation therapy (IGRT), and intensity-modulated (IMRT) techniques. At the root of these advancements lie improvements in tumor imaging, image alignment (registration), target volume delineation, and identification of critical structures. Image registration has been widely used to combine information from multimodality images such as computerized tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) to improve the accuracy of radiation delivery and reliably identify tumor-bearing areas. Many different techniques have been applied in image registration. This review provides an overview of medical image registration in RT and its applications in veterinary oncology. A summary of the most commonly used approaches in human and veterinary medicine is presented along with their current use in IGRT and adaptive radiation therapy (ART). It is important to realize that registration does not guarantee that target volumes, such as the gross tumor volume (GTV), are correctly identified on the image being registered, as limitations unique to registration algorithms exist. Research involving novel registration frameworks for automatic segmentation of tumor volumes is ongoing and comparative oncology programs offer a unique opportunity to test the efficacy of proposed algorithms. PMID:26777133

  10. INVITED REVIEW--IMAGE REGISTRATION IN VETERINARY RADIATION ONCOLOGY: INDICATIONS, IMPLICATIONS, AND FUTURE ADVANCES.

    PubMed

    Feng, Yang; Lawrence, Jessica; Cheng, Kun; Montgomery, Dean; Forrest, Lisa; Mclaren, Duncan B; McLaughlin, Stephen; Argyle, David J; Nailon, William H

    2016-01-01

    The field of veterinary radiation therapy (RT) has gained substantial momentum in recent decades with significant advances in conformal treatment planning, image-guided radiation therapy (IGRT), and intensity-modulated (IMRT) techniques. At the root of these advancements lie improvements in tumor imaging, image alignment (registration), target volume delineation, and identification of critical structures. Image registration has been widely used to combine information from multimodality images such as computerized tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) to improve the accuracy of radiation delivery and reliably identify tumor-bearing areas. Many different techniques have been applied in image registration. This review provides an overview of medical image registration in RT and its applications in veterinary oncology. A summary of the most commonly used approaches in human and veterinary medicine is presented along with their current use in IGRT and adaptive radiation therapy (ART). It is important to realize that registration does not guarantee that target volumes, such as the gross tumor volume (GTV), are correctly identified on the image being registered, as limitations unique to registration algorithms exist. Research involving novel registration frameworks for automatic segmentation of tumor volumes is ongoing and comparative oncology programs offer a unique opportunity to test the efficacy of proposed algorithms.

  11. Dawn of advanced molecular medicine: nanotechnological advancements in cancer imaging and therapy.

    PubMed

    Kaittanis, Charalambos; Shaffer, Travis M; Thorek, Daniel L J; Grimm, Jan

    2014-01-01

    Nanotechnology plays an increasingly important role not only in our everyday life (with all its benefits and dangers) but also in medicine. Nanoparticles are to date the most intriguing option to deliver high concentrations of agents specifically and directly to cancer cells; therefore, a wide variety of these nanomaterials has been developed and explored. These span the range from simple nanoagents to sophisticated smart devices for drug delivery or imaging. Nanomaterials usually provide a large surface area, allowing for decoration with a large amount of moieties on the surface for either additional functionalities or targeting. Besides using particles solely for imaging purposes, they can also carry as a payload a therapeutic agent. If both are combined within the same particle, a theranostic agent is created. The sophistication of highly developed nanotechnology targeting approaches provides a promising means for many clinical implementations and can provide improved applications for otherwise suboptimal formulations. In this review we will explore nanotechnology both for imaging and therapy to provide a general overview of the field and its impact on cancer imaging and therapy. PMID:25271430

  12. Dawn of Advanced Molecular Medicine: Nanotechnological Advancements in Cancer Imaging and Therapy

    PubMed Central

    Kaittanis, Charalambos; Shaffer, Travis M.; Thorek, Daniel L. J.; Grimm, Jan

    2014-01-01

    Nanotechnology plays an increasingly important role not only in our everyday life (with all its benefits and dangers) but also in medicine. Nanoparticles are to date the most intriguing option to deliver high concentrations of agents specifically and directly to cancer cells; therefore, a wide variety of these nanomaterials has been developed and explored. These span the range from simple nanoagents to sophisticated smart devices for drug delivery or imaging. Nanomaterials usually provide a large surface area, allowing for decoration with a large amount of moieties on the surface for either additional functionalities or targeting. Besides using particles solely for imaging purposes, they can also carry as a payload a therapeutic agent. If both are combined within the same particle, a theranostic agent is created. The sophistication of highly developed nanotechnology targeting approaches provides a promising means for many clinical implementations and can provide improved applications for otherwise suboptimal formulations. In this review we will explore nanotechnology both for imaging and therapy to provide a general overview of the field and its impact on cancer imaging and therapy. PMID:25271430

  13. Technological advances in hybrid imaging and impact on dose.

    PubMed

    Mattsson, Sören; Andersson, Martin; Söderberg, Marcus

    2015-07-01

    New imaging technologies utilising X-rays and radiopharmaceuticals have developed rapidly. Clinical application of computed tomography (CT) has revolutionised medical imaging and plays an enormous role in medical care. Due to technical improvements, spatial, contrast and temporal resolutions have continuously improved. In spite of significant reduction of CT doses during recent years, CT is still a dominating source of radiation exposure to the population. Combinations with single photon emission computed tomography (SPECT) and positron emission tomography (PET) and especially the use of SPECT/CT and PET/CT, provide important additional information about physiology as well as cellular and molecular events. However, significant dose contributions from SPECT and PET occur, making PET/CT and SPECT/CT truly high dose procedures. More research should be done to find optimal activities of radiopharmaceuticals for various patient groups and investigations. The implementation of simple protocol adjustments, including individually based administration, encouraged hydration, forced diuresis and use of optimised voiding intervals, laxatives, etc., can reduce the radiation exposure to the patients. New data about staff doses to fingers, hands and eye lenses indicate that finger doses could be a problem, but not doses to the eye lenses and to the whole body.

  14. Crosswell Imaging Technology & Advanced DSR Navigation for Horizontal Directional Drilling

    SciTech Connect

    Larry Stolarczyk

    2008-08-08

    The objective of Phase II is to develop and demonstrate real-time measurement-while-drilling (MWD) for guidance and navigation of drill strings during horizontal drilling operations applicable to both short and long holes. The end product of Phase II is a functional drill-string assembly outfitted with a commercial version of Drill String Radar (DSR). Project Objectives Develop and demonstrate a dual-phase methodology of in-seam drilling, imaging, and structure confirmation. This methodology, illustrated in Figure 1, includes: (1) Using RIM to image between drill holes for seam thickness estimates and in-seam structures detection. Completed, February 2005; and (2) Using DSR for real-time MWD guidance and navigation of drillstrings during horizontal drilling operations. Completed, November 2008. As of November 2008, the Phase II portion of Contract DE-FC26-04NT42085 is about 99% complete, including milestones and tasks original outlined as Phase II work. The one percent deficiency results from MSHA-related approvals which have yet to be granted (at the time of reporting). These approvals are pending and are do not negatively impact the scope of work or project objectives.

  15. Adaptation of commercial microscopes for advanced imaging applications

    NASA Astrophysics Data System (ADS)

    Brideau, Craig; Poon, Kelvin; Stys, Peter

    2015-03-01

    Today's commercially available microscopes offer a wide array of options to accommodate common imaging experiments. Occasionally, an experimental goal will require an unusual light source, filter, or even irregular sample that is not compatible with existing equipment. In these situations the ability to modify an existing microscopy platform with custom accessories can greatly extend its utility and allow for experiments not possible with stock equipment. Light source conditioning/manipulation such as polarization, beam diameter or even custom source filtering can easily be added with bulk components. Custom and after-market detectors can be added to external ports using optical construction hardware and adapters. This paper will present various examples of modifications carried out on commercial microscopes to address both atypical imaging modalities and research needs. Violet and near-ultraviolet source adaptation, custom detection filtering, and laser beam conditioning and control modifications will be demonstrated. The availability of basic `building block' parts will be discussed with respect to user safety, construction strategies, and ease of use.

  16. Automated angiogenesis quantification through advanced image processing techniques.

    PubMed

    Doukas, Charlampos N; Maglogiannis, Ilias; Chatziioannou, Aristotle; Papapetropoulos, Andreas

    2006-01-01

    Angiogenesis, the formation of blood vessels in tumors, is an interactive process between tumor, endothelial and stromal cells in order to create a network for oxygen and nutrients supply, necessary for tumor growth. According to this, angiogenic activity is considered a suitable method for both tumor growth or inhibition detection. The angiogenic potential is usually estimated by counting the number of blood vessels in particular sections. One of the most popular assay tissues to study the angiogenesis phenomenon is the developing chick embryo and its chorioallantoic membrane (CAM), which is a highly vascular structure lining the inner surface of the egg shell. The aim of this study was to develop and validate an automated image analysis method that would give an unbiased quantification of the micro-vessel density and growth in angiogenic CAM images. The presented method has been validated by comparing automated results to manual counts over a series of digital chick embryo photos. The results indicate the high accuracy of the tool, which has been thus extensively used for tumor growth detection at different stages of embryonic development. PMID:17946107

  17. Advanced electron crystallography through model-based imaging

    PubMed Central

    Van Aert, Sandra; De Backer, Annick; Martinez, Gerardo T.; den Dekker, Arnold J.; Van Dyck, Dirk; Bals, Sara; Van Tendeloo, Gustaaf

    2016-01-01

    The increasing need for precise determination of the atomic arrangement of non-periodic structures in materials design and the control of nanostructures explains the growing interest in quantitative transmission electron microscopy. The aim is to extract precise and accurate numbers for unknown structure parameters including atomic positions, chemical concentrations and atomic numbers. For this purpose, statistical parameter estimation theory has been shown to provide reliable results. In this theory, observations are considered purely as data planes, from which structure parameters have to be determined using a parametric model describing the images. As such, the positions of atom columns can be measured with a precision of the order of a few picometres, even though the resolution of the electron microscope is still one or two orders of magnitude larger. Moreover, small differences in average atomic number, which cannot be distinguished visually, can be quantified using high-angle annular dark-field scanning transmission electron microscopy images. In addition, this theory allows one to measure compositional changes at interfaces, to count atoms with single-atom sensitivity, and to reconstruct atomic structures in three dimensions. This feature article brings the reader up to date, summarizing the underlying theory and highlighting some of the recent applications of quantitative model-based transmisson electron microscopy. PMID:26870383

  18. Advanced electron crystallography through model-based imaging.

    PubMed

    Van Aert, Sandra; De Backer, Annick; Martinez, Gerardo T; den Dekker, Arnold J; Van Dyck, Dirk; Bals, Sara; Van Tendeloo, Gustaaf

    2016-01-01

    The increasing need for precise determination of the atomic arrangement of non-periodic structures in materials design and the control of nanostructures explains the growing interest in quantitative transmission electron microscopy. The aim is to extract precise and accurate numbers for unknown structure parameters including atomic positions, chemical concentrations and atomic numbers. For this purpose, statistical parameter estimation theory has been shown to provide reliable results. In this theory, observations are considered purely as data planes, from which structure parameters have to be determined using a parametric model describing the images. As such, the positions of atom columns can be measured with a precision of the order of a few picometres, even though the resolution of the electron microscope is still one or two orders of magnitude larger. Moreover, small differences in average atomic number, which cannot be distinguished visually, can be quantified using high-angle annular dark-field scanning transmission electron microscopy images. In addition, this theory allows one to measure compositional changes at interfaces, to count atoms with single-atom sensitivity, and to reconstruct atomic structures in three dimensions. This feature article brings the reader up to date, summarizing the underlying theory and highlighting some of the recent applications of quantitative model-based transmisson electron microscopy. PMID:26870383

  19. Advances in endoscopic ultrasound imaging of colorectal diseases.

    PubMed

    Cârțână, Elena Tatiana; Gheonea, Dan Ionuț; Săftoiu, Adrian

    2016-02-01

    The development of endoscopic ultrasound (EUS) has had a significant impact for patients with digestive diseases, enabling enhanced diagnostic and therapeutic procedures, with most of the available evidence focusing on upper gastrointestinal (GI) and pancreatico-biliary diseases. For the lower GI tract the main application of EUS has been in staging rectal cancer, as a complementary technique to other cross-sectional imaging methods. EUS can provide highly accurate in-depth assessments of tumour infiltration, performing best in the diagnosis of early rectal tumours. In the light of recent developments other EUS applications for colorectal diseases have been also envisaged and are currently under investigation, including beyond-rectum tumour staging by means of the newly developed forward-viewing radial array echoendoscope. Due to its high resolution, EUS might be also regarded as an ideal method for the evaluation of subepithelial lesions. Their differential diagnosis is possible by imaging the originating wall layer and the associated echostructure, and cytological and histological confirmation can be obtained through EUS-guided fine needle aspiration or trucut biopsy. However, reports on the use of EUS in colorectal subepithelial lesions are currently limited. EUS allows detailed examination of perirectal and perianal complications in Crohn's disease and, as a safe and less expensive investigation, can be used to monitor therapeutic response of fistulae, which seems to improve outcomes and reduce the need for additional surgery. Furthermore, EUS image enhancement techniques, such as the use of contrast agents or elastography, have recently been evaluated for colorectal indications as well. Possible applications of contrast enhancement include the assessment of tumour angiogenesis in colorectal cancer, the monitoring of disease activity in inflammatory bowel disease based on quantification of bowel wall vascularization, and differentiating between benign and

  20. Advanced astigmatism-corrected Czerny-Turner imaging spectrometer in spectral broadband

    NASA Astrophysics Data System (ADS)

    Cong, Hai-fang

    2014-12-01

    This paper reports an advanced Czerny-Turner optical structure which is used for the application in imaging spectrometers. To obtain the excellent imaging quality, a cylindrical lens with a wedge angle is used between the focusing mirror and the imaging plane to remove astigmatism in broadband. It makes the advanced optical system presents high resolution over the full bandwidth and decreases the cost. An example of the imaging spectrometer in the waveband of 260nm~520nm has been designed to prove our theory. It yields the excellent modulation transfer functions (MTF) of all fields of view which are more than 0.75 over the broadband under the required Nyquist frequency (20lp/mm).

  1. Advanced satellite sensors: Low Energy Neutral Atom (LENA) imager

    SciTech Connect

    Funsten, H.O.; McComas, D.J.

    1996-09-01

    This is the final report of a three-year, Laboratory-Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). Imaging of low energy neutral atoms (LENDs) created by electron capture by magnetospheric plasma ions from interactions with cold geocoronal neutrals promises to be a revolutionary technique for providing unprecedented information about the global structure and dynamics of the terrestrial magnetosphere. This has significant implications in space weather forecasting, weather-induced satellite upset diagnostics, and revolutionary insights into global magnetospheric physics. The Los Alamos Space and Atmospheric Sciences Group has completed extensive neutral atom simulations and detailed instrument definition, and we designed a proof-of-concept demonstration prototype and have obtained externally- funded programs for full instrument development

  2. Advanced Image Processing for Defect Visualization in Infrared Thermography

    NASA Technical Reports Server (NTRS)

    Plotnikov, Yuri A.; Winfree, William P.

    1997-01-01

    Results of a defect visualization process based on pulse infrared thermography are presented. Algorithms have been developed to reduce the amount of operator participation required in the process of interpreting thermographic images. The algorithms determine the defect's depth and size from the temporal and spatial thermal distributions that exist on the surface of the investigated object following thermal excitation. A comparison of the results from thermal contrast, time derivative, and phase analysis methods for defect visualization are presented. These comparisons are based on three dimensional simulations of a test case representing a plate with multiple delaminations. Comparisons are also based on experimental data obtained from a specimen with flat bottom holes and a composite panel with delaminations.

  3. Advances in photo-thermal infrared imaging microspectroscopy

    NASA Astrophysics Data System (ADS)

    Furstenberg, Robert; Kendziora, Chris; Papantonakis, Michael; Nguyen, Viet; McGill, Andrew

    2013-05-01

    There is a growing need for chemical imaging techniques in many fields of science and technology: forensics, materials science, pharmaceutical and chemical industries, just to name a few. While FTIR micro-spectroscopy is commonly used, its practical resolution limit of about 20 microns or more is often insufficient. Raman micro-spectroscopy provides better spatial resolution (~1 micron), but is not always practical because of samples exhibiting fluorescence or low Raman scattering efficiency. We are developing a non-contact and non-destructive technique we call photo-thermal infrared imaging spectroscopy (PT-IRIS). It involves photo-thermal heating of the sample with a tunable quantum cascade laser and measuring the resulting increase in thermal emission with an infrared detector. Photo-thermal emission spectra resemble FTIR absorbance spectra and can be acquired in both stand-off and microscopy configurations. Furthermore, PT-IRIS allows the acquisition of absorbance-like photo-thermal spectra in a reflected geometry, suitable for field applications and for in-situ study of samples on optically IR-opaque substrates (metals, fabrics, paint, glass etc.). Conventional FTIR microscopes in reflection mode measure the reflectance spectra which are different from absorbance spectra and are usually not catalogued in FTIR spectral libraries. In this paper, we continue developing this new technique. We perform a series of numerical simulations of the laser heating of samples during photo-thermal microscopy. We develop parameterized formulas to help the user pick the appropriate laser illumination power. We also examine the influence of sample geometry on spectral signatures. Finally, we measure and compare photo-thermal and reflectance spectra for two test samples.

  4. Advanced tools for astronomical time series and image analysis

    NASA Astrophysics Data System (ADS)

    Scargle, Jeffrey D.

    The algorithms described here, which I have developed for applications in X-ray and γ-ray astronomy, will hopefully be of use in other ways, perhaps aiding in the exploration of modern astronomy's data cornucopia. The goal is to describe principled approaches to some ubiquitous problems, such as detection and characterization of periodic and aperiodic signals, estimation of time delays between multiple time series, and source detection in noisy images with noisy backgrounds. The latter problem is related to detection of clusters in data spaces of various dimensions. A goal of this work is to achieve a unifying view of several related topics: signal detection and characterization, cluster identification, classification, density estimation, and multivariate regression. In addition to being useful for analysis of data from space-based and ground-based missions, these algorithms may be a basis for a future automatic science discovery facility, and in turn provide analysis tools for the Virtual Observatory. This chapter has ties to those by Larry Bretthorst, Tom Loredo, Alanna Connors, Fionn Murtagh, Jim Berger, David van Dyk, Vicent Martinez & Enn Saar.

  5. A survey of advanced excimer optical imaging and lithography

    NASA Astrophysics Data System (ADS)

    Matsumoto, Koichi; Suwa, Kyoichi

    1998-11-01

    The first item discussed in this paper is to estimate the future trend regarding minimum geometry and the optical parameters, such as NA and wavelength. Simulations based on aerial images are performed for the estimation. The resolution limit is defined as a minimum feature size which retains practical depth of focus (DOF). Pattern geometry is classified into two categories, which are dense lines and isolated lines. Available wavelengths are assumed to be KrF excimer laser (λ=248 nm), ArF excimer laser (λ=193 nm) and F2 excimer laser (λ=157 nm). Based upon the simulation results, the resolution limit is estimated for each geometry and each wavelength. The second item is to survey ArF optics. At present, the ArF excimer laser is regarded as one of the most promising candidates as a next-generation light source. Discussions are ranging over some critical issues. The lifetime of ArF optics supposedly limited by the radiation compaction of silica glass is estimated in comparison with KrF optics. Availability of calcium fluoride (CaF2) is also discussed. As a designing issue, a comparative study is made about the optical configuration, dioptric or catadioptric. In the end, our resist-based performance is shown.

  6. Significant advancement of mass spectrometry imaging for food chemistry.

    PubMed

    Yoshimura, Yukihiro; Goto-Inoue, Naoko; Moriyama, Tatsuya; Zaima, Nobuhiro

    2016-11-01

    Food contains various compounds that have an impact on our daily lives. Many technologies have been established to analyze these molecules of interest in foods. However, the analysis of the spatial distribution of these compounds in foods using conventional technology, such as high-performance liquid chromatography-mass spectrometry or gas chromatography-mass spectrometry is difficult. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is considered an ideal complementary approach. MALDI-MSI is a two-dimensional MALDI-MS technology that can detect compounds in a tissue section without extraction, purification, separation, or labeling. MALDI-MSI can be used to visualize the spatial distribution of chemical compounds or biomolecules in foods. Although the methodology of MALDI-MSI in food science is not yet fully established, the versatility of MALDI-MSI is expected to open a new frontier in food science. Herein, we describe the principles and applications of MALDI-MSI in food science and related fields.

  7. Advanced endoscopic imaging for gastric cancer assessment: new insights with new optics?

    PubMed

    Serrano, M; Kikuste, I; Dinis-Ribeiro, M

    2014-12-01

    The most immediate strategy for improving survival of gastric cancer patients is secondary prevention through diagnosis of early gastric cancer either through screening or follow-up of individuals at high risk. Endoscopy examination is therefore of paramount importance and two general steps are to be known in assessing gastric mucosa - detection and characterization. Over the past decade, the advent of advanced endoscopic imaging technology led to diverse descriptions of these modalities reporting them to be useful in this setting. In this review, we aim at summarizing the current evidence on the use of advance imaging in individuals at high-risk (i.e., advance stages of gastric atrophy/intestinal metaplasia) and in those harbouring neoplastic lesions, and address its potential usefulness providing the readers a framework to use in daily practice. Further research is also suggested.

  8. MO-C-18A-01: Advances in Model-Based 3D Image Reconstruction

    SciTech Connect

    Chen, G; Pan, X; Stayman, J; Samei, E

    2014-06-15

    Recent years have seen the emergence of CT image reconstruction techniques that exploit physical models of the imaging system, photon statistics, and even the patient to achieve improved 3D image quality and/or reduction of radiation dose. With numerous advantages in comparison to conventional 3D filtered backprojection, such techniques bring a variety of challenges as well, including: a demanding computational load associated with sophisticated forward models and iterative optimization methods; nonlinearity and nonstationarity in image quality characteristics; a complex dependency on multiple free parameters; and the need to understand how best to incorporate prior information (including patient-specific prior images) within the reconstruction process. The advantages, however, are even greater – for example: improved image quality; reduced dose; robustness to noise and artifacts; task-specific reconstruction protocols; suitability to novel CT imaging platforms and noncircular orbits; and incorporation of known characteristics of the imager and patient that are conventionally discarded. This symposium features experts in 3D image reconstruction, image quality assessment, and the translation of such methods to emerging clinical applications. Dr. Chen will address novel methods for the incorporation of prior information in 3D and 4D CT reconstruction techniques. Dr. Pan will show recent advances in optimization-based reconstruction that enable potential reduction of dose and sampling requirements. Dr. Stayman will describe a “task-based imaging” approach that leverages models of the imaging system and patient in combination with a specification of the imaging task to optimize both the acquisition and reconstruction process. Dr. Samei will describe the development of methods for image quality assessment in such nonlinear reconstruction techniques and the use of these methods to characterize and optimize image quality and dose in a spectrum of clinical

  9. Recent Advances in CT and MR Imaging for Evaluation of Hepatocellular Carcinoma

    PubMed Central

    Lee, Jeong Min; Yoon, Jeong-Hee; Joo, Ijin; Woo, Hyun Sik

    2012-01-01

    Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Accurate diagnosis and assessment of disease extent are crucial for proper management of patients with HCC. Imaging plays a crucial role in early detection, accurate staging, and the planning of management strategies. A variety of imaging modalities are currently used in evaluating patients with suspected HCC; these include ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine, and angiography. Among these modalities, dynamic MRI and CT are regarded as the best imaging techniques available for the noninvasive diagnosis of HCC. Recent improvements in CT and MRI technology have made noninvasive and reliable diagnostic assessment of hepatocellular nodules possible in the cirrhotic liver, and biopsy is frequently not required prior to treatment. Until now, the major challenge for radiologists in imaging cirrhosis has been the characterization of small cirrhotic nodules smaller than 2 cm in diameter. Further technological advancement will undoubtedly have a major impact on liver tumor imaging. The increased speed of data acquisition in CT and MRI has allowed improvements in both spatial and temporal resolution, which have made possible a more precise evaluation of the hemodynamics of liver nodules. Furthermore, the development of new, tissue-specific contrast agents such as gadoxetic acid has improved HCC detection on MRI. In this review, we discuss the role of CT and MRI in the diagnosis and staging of HCC, recent technological advances, and the strengths and limitations of these imaging modalities. PMID:24159569

  10. Advances in probing the blood vessels of the human brain using magnetic resonance imaging

    NASA Astrophysics Data System (ADS)

    Haacke, E. Mark

    2002-03-01

    Magnetic resonance imaging offers a marvelous means to probe the vasculature of the human body non-invasively. The first major advances came when the physics of the effects of motion in MRI were first understood well enough that new methods could be designed to compensate for the motion. This led to the development of MR angiography. The second major advance occurred when a contrast agent was used to enhance the signal from vessels independent of blood flow. This made it possible to image much smaller vessels because of the increased signal-to-noise ratio. The third major advance occurred when the susceptibility of the venous blood was used to create a new contrast unique to veins even in the presence of the contrast agent to enhance their signal. The fourth advance is close behind with the potential to use the susceptibility to measure the local oxygen content. Each of these advances involved some interesting physics and raised questions about local magnetic field effects, some of which remain unanswered yet today. We will show results from the first three levels with hints at how to proceed to the fourth. The development of this technology has important clinical implications. With new higher relaxivity contrast agents and higher field magnets coming on the market, the possibility to image vessels down to on the order of 100 microns may be viable. Each advance has enhanced the range of applications from just imaging vessels to occult vascular disease, trauma, the detection of blood products, and physiologic function of the tissue itself.

  11. Clinical decision support systems for brain tumor characterization using advanced magnetic resonance imaging techniques.

    PubMed

    Tsolaki, Evangelia; Kousi, Evanthia; Svolos, Patricia; Kapsalaki, Efthychia; Theodorou, Kyriaki; Kappas, Constastine; Tsougos, Ioannis

    2014-04-28

    In recent years, advanced magnetic resonance imaging (MRI) techniques, such as magnetic resonance spectroscopy, diffusion weighted imaging, diffusion tensor imaging and perfusion weighted imaging have been used in order to resolve demanding diagnostic problems such as brain tumor characterization and grading, as these techniques offer a more detailed and non-invasive evaluation of the area under study. In the last decade a great effort has been made to import and utilize intelligent systems in the so-called clinical decision support systems (CDSS) for automatic processing, classification, evaluation and representation of MRI data in order for advanced MRI techniques to become a part of the clinical routine, since the amount of data from the aforementioned techniques has gradually increased. Hence, the purpose of the current review article is two-fold. The first is to review and evaluate the progress that has been made towards the utilization of CDSS based on data from advanced MRI techniques. The second is to analyze and propose the future work that has to be done, based on the existing problems and challenges, especially taking into account the new imaging techniques and parameters that can be introduced into intelligent systems to significantly improve their diagnostic specificity and clinical application.

  12. Basic principles and concepts underlying recent advances in magnetic resonance imaging of the developing brain.

    PubMed

    Panigrahy, Ashok; Borzage, Matthew; Blüml, Stefan

    2010-02-01

    Over the last decade, magnetic resonance (MR) imaging has become an essential tool in the evaluation of both in vivo human brain development and perinatal brain injury. Recent technology including MR-compatible neonatal incubators, neonatal head coils, advanced MR pulse sequences, and 3-T field strength magnets allow high-quality MR imaging studies to be performed on sick neonates. This article will review basic principles and concepts underlying recent advances in MR spectroscopy, diffusion, perfusion, and volumetric MR imaging. These techniques provide quantitative assessment and novel insight of both brain development and brain injury in the immature brain. Knowledge of normal developmental changes in quantitative MR values is also essential to interpret pathologic cases.

  13. Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.

    PubMed

    Kremer, Stephane; Renard, Felix; Achard, Sophie; Lana-Peixoto, Marco A; Palace, Jacqueline; Asgari, Nasrin; Klawiter, Eric C; Tenembaum, Silvia N; Banwell, Brenda; Greenberg, Benjamin M; Bennett, Jeffrey L; Levy, Michael; Villoslada, Pablo; Saiz, Albert; Fujihara, Kazuo; Chan, Koon Ho; Schippling, Sven; Paul, Friedemann; Kim, Ho Jin; de Seze, Jerome; Wuerfel, Jens T; Cabre, Philippe; Marignier, Romain; Tedder, Thomas; van Pelt, Danielle; Broadley, Simon; Chitnis, Tanuja; Wingerchuk, Dean; Pandit, Lekha; Leite, Maria Isabel; Apiwattanakul, Metha; Kleiter, Ingo; Prayoonwiwat, Naraporn; Han, May; Hellwig, Kerstin; van Herle, Katja; John, Gareth; Hooper, D Craig; Nakashima, Ichiro; Sato, Douglas; Yeaman, Michael R; Waubant, Emmanuelle; Zamvil, Scott; Stüve, Olaf; Aktas, Orhan; Smith, Terry J; Jacob, Anu; O'Connor, Kevin

    2015-07-01

    Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.

  14. Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

    PubMed Central

    Kremer, Stephane; Renard, Felix; Achard, Sophie; Lana-Peixoto, Marco A.; Palace, Jacqueline; Asgari, Nasrin; Klawiter, Eric C.; Tenembaum, Silvia N.; Banwell, Brenda; Greenberg, Benjamin M.; Bennett, Jeffrey L.; Levy, Michael; Villoslada, Pablo; Saiz, Albert; Fujihara, Kazuo; Chan, Koon Ho; Schippling, Sven; Paul, Friedemann; Kim, Ho Jin; de Seze, Jerome; Wuerfel, Jens T.

    2016-01-01

    Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease. PMID:26010909

  15. Advances in retinal imaging for diabetic retinopathy and diabetic macular edema.

    PubMed

    Tan, Colin Siang Hui; Chew, Milton Cher Yong; Lim, Louis Wei Yi; Sadda, Srinivas R

    2016-01-01

    Diabetic retinopathy and diabetic macular edema (DME) are leading causes of blindness throughout the world, and cause significant visual morbidity. Ocular imaging has played a significant role in the management of diabetic eye disease, and the advent of advanced imaging modalities will be of great value as our understanding of diabetic eye diseases increase, and the management options become increasingly varied and complex. Color fundus photography has established roles in screening for diabetic eye disease, early detection of progression, and monitoring of treatment response. Fluorescein angiography (FA) detects areas of capillary nonperfusion, as well as leakage from both microaneurysms and neovascularization. Recent advances in retinal imaging modalities complement traditional fundus photography and provide invaluable new information for clinicians. Ultra-widefield imaging, which can be used to produce both color fundus photographs and FAs, now allows unprecedented views of the posterior pole. The pathologies that are detected in the periphery of the retina have the potential to change the grading of disease severity, and may be of prognostic significance to disease progression. Studies have shown that peripheral ischemia may be related to the presence and severity of DME. Optical coherence tomography (OCT) provides structural detail of the retina, and the quantitative and qualitative features are useful in the monitoring of diabetic eye disease. A relatively recent innovation, OCT angiography, produces images of the fine blood vessels at the macula and optic disc, without the need for contrast agents. This paper will review the roles of each of these imaging modalities for diabetic eye disease.

  16. Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder.

    PubMed

    Kremer, Stephane; Renard, Felix; Achard, Sophie; Lana-Peixoto, Marco A; Palace, Jacqueline; Asgari, Nasrin; Klawiter, Eric C; Tenembaum, Silvia N; Banwell, Brenda; Greenberg, Benjamin M; Bennett, Jeffrey L; Levy, Michael; Villoslada, Pablo; Saiz, Albert; Fujihara, Kazuo; Chan, Koon Ho; Schippling, Sven; Paul, Friedemann; Kim, Ho Jin; de Seze, Jerome; Wuerfel, Jens T; Cabre, Philippe; Marignier, Romain; Tedder, Thomas; van Pelt, Danielle; Broadley, Simon; Chitnis, Tanuja; Wingerchuk, Dean; Pandit, Lekha; Leite, Maria Isabel; Apiwattanakul, Metha; Kleiter, Ingo; Prayoonwiwat, Naraporn; Han, May; Hellwig, Kerstin; van Herle, Katja; John, Gareth; Hooper, D Craig; Nakashima, Ichiro; Sato, Douglas; Yeaman, Michael R; Waubant, Emmanuelle; Zamvil, Scott; Stüve, Olaf; Aktas, Orhan; Smith, Terry J; Jacob, Anu; O'Connor, Kevin

    2015-07-01

    Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease. PMID:26010909

  17. Prostate Radiotherapy in the Era of Advanced Imaging and Precision Medicine

    PubMed Central

    Dulaney, Caleb R.; Osula, Daniel O.; Yang, Eddy S.; Rais-Bahrami, Soroush

    2016-01-01

    Tremendous technological advancements in prostate radiotherapy have decreased treatment toxicity and improved clinical outcomes for men with prostate cancer. While these advances have allowed for significant treatment volume reduction and whole-organ dose escalation, further improvement in prostate radiotherapy has been limited by classic techniques for diagnosis and risk stratification. Developments in prostate imaging, image-guided targeted biopsy, next-generation gene expression profiling, and targeted molecular therapies now provide information to stratify patients and select treatments based on tumor biology. Image-guided targeted biopsy improves detection of clinically significant cases of prostate cancer and provides important information about the biological behavior of intraprostatic lesions which can further guide treatment decisions. We review the evolution of prostate magnetic resonance imaging (MRI) and MRI-ultrasound fusion-guided prostate biopsy. Recent advancements in radiation therapy including dose escalation, moderate and extreme hypofractionation, partial prostate radiation therapy, and finally dose escalation by simultaneous integrated boost are discussed. We also review next-generation sequencing and discuss developments in targeted molecular therapies. Last, we review ongoing clinical trials and future treatment paradigms that integrate targeted biopsy, molecular profiling and therapy, and prostate radiotherapy. PMID:27022486

  18. Where in the Cell Are You? Probing HIV-1 Host Interactions through Advanced Imaging Techniques

    PubMed Central

    Dirk, Brennan S.; Van Nynatten, Logan R.; Dikeakos, Jimmy D.

    2016-01-01

    Viruses must continuously evolve to hijack the host cell machinery in order to successfully replicate and orchestrate key interactions that support their persistence. The type-1 human immunodeficiency virus (HIV-1) is a prime example of viral persistence within the host, having plagued the human population for decades. In recent years, advances in cellular imaging and molecular biology have aided the elucidation of key steps mediating the HIV-1 lifecycle and viral pathogenesis. Super-resolution imaging techniques such as stimulated emission depletion (STED) and photoactivation and localization microscopy (PALM) have been instrumental in studying viral assembly and release through both cell–cell transmission and cell–free viral transmission. Moreover, powerful methods such as Forster resonance energy transfer (FRET) and bimolecular fluorescence complementation (BiFC) have shed light on the protein-protein interactions HIV-1 engages within the host to hijack the cellular machinery. Specific advancements in live cell imaging in combination with the use of multicolor viral particles have become indispensable to unravelling the dynamic nature of these virus-host interactions. In the current review, we outline novel imaging methods that have been used to study the HIV-1 lifecycle and highlight advancements in the cell culture models developed to enhance our understanding of the HIV-1 lifecycle. PMID:27775563

  19. Can Imaging Put the “Advanced” Back in Advanced Wound Care?

    PubMed Central

    DaCosta, Ralph S.; Ottolino-Perry, Kathryn; Banerjee, Jaideep

    2016-01-01

    An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless “innovative” treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been innovation in wound diagnostics. Whereas medical imaging is a mainstay in the diagnostic toolkit across many other medical fields (oncology, neurology, gastroenterology, orthopedics, etc.), the field of wound care has yet to realize the full potential that advances in imaging technologies have to offer the clinician. In this issue, the first of a series in wound imaging and diagnostics, four articles have been assembled, highlighting some of the recent advances in wound imaging technologies.

  20. Advances in molecular imaging: targeted optical contrast agents for cancer diagnostics

    PubMed Central

    Hellebust, Anne; Richards-Kortum, Rebecca

    2012-01-01

    Over the last three decades, our understanding of the molecular changes associated with cancer development and progression has advanced greatly. This has led to new cancer therapeutics targeted against specific molecular pathways; such therapies show great promise to reduce mortality, in part by enabling physicians to tailor therapy for patients based on a molecular profile of their tumor. Unfortunately, the tools for definitive cancer diagnosis – light microscopic examination of biopsied tissue stained with nonspecific dyes – remain focused on the analysis of tissue ex vivo. There is an important need for new clinical tools to support the molecular diagnosis of cancer. Optical molecular imaging is emerging as a technique to help meet this need. Targeted, optically active contrast agents can specifically label extra-and intracellular biomarkers of cancer. Optical images can be acquired in real time with high spatial resolution to image-specific molecular targets, while still providing morphologic context. This article reviews recent advances in optical molecular imaging, highlighting the advances in technology required to improve early cancer detection, guide selection of targeted therapy and rapidly evaluate therapeutic efficacy. PMID:22385200

  1. Advanced astigmatism-corrected tandem Wadsworth mounting for small-scale spectral broadband imaging spectrometer.

    PubMed

    Lei, Yu; Lin, Guan-yu

    2013-01-01

    Tandem gratings of double-dispersion mount make it possible to design an imaging spectrometer for the weak light observation with high spatial resolution, high spectral resolution, and high optical transmission efficiency. The traditional tandem Wadsworth mounting is originally designed to match the coaxial telescope and large-scale imaging spectrometer. When it is used to connect the off-axis telescope such as off-axis parabolic mirror, it presents lower imaging quality than to connect the coaxial telescope. It may also introduce interference among the detector and the optical elements as it is applied to the short focal length and small-scale spectrometer in a close volume by satellite. An advanced tandem Wadsworth mounting has been investigated to deal with the situation. The Wadsworth astigmatism-corrected mounting condition for which is expressed as the distance between the second concave grating and the imaging plane is calculated. Then the optimum arrangement for the first plane grating and the second concave grating, which make the anterior Wadsworth condition fulfilling each wavelength, is analyzed by the geometric and first order differential calculation. These two arrangements comprise the advanced Wadsworth mounting condition. The spectral resolution has also been calculated by these conditions. An example designed by the optimum theory proves that the advanced tandem Wadsworth mounting performs excellently in spectral broadband. PMID:23292378

  2. Can Imaging Put the “Advanced” Back in Advanced Wound Care?

    PubMed Central

    DaCosta, Ralph S.; Ottolino-Perry, Kathryn; Banerjee, Jaideep

    2016-01-01

    An effective, scientifically validated, diagnostic tool helps clinicians make better, timely, and more objective medical decisions in the care of their patients. Today, the need for such tools is especially urgent in the field of wound care where patient-centric care is the goal, under ever tightening clinical budget constraints. In an era of countless “innovative” treatment options, that is, advanced dressings, negative pressure devices, and various debridement instruments available to the wound care clinical team, one area that has arguably languished in the past decade has been innovation in wound diagnostics. Whereas medical imaging is a mainstay in the diagnostic toolkit across many other medical fields (oncology, neurology, gastroenterology, orthopedics, etc.), the field of wound care has yet to realize the full potential that advances in imaging technologies have to offer the clinician. In this issue, the first of a series in wound imaging and diagnostics, four articles have been assembled, highlighting some of the recent advances in wound imaging technologies. PMID:27602251

  3. Targeted radionuclide and fluorescence dual-modality imaging of cancer: preclinical advances and clinical translation.

    PubMed

    Lütje, S; Rijpkema, M; Helfrich, W; Oyen, W J G; Boerman, O C

    2014-12-01

    In oncology, sensitive and reliable detection tumor tissue is crucial to prevent recurrences and to improve surgical outcome. Currently, extensive research is focused on the use of radionuclides as well as fluorophores to provide real-time guidance during surgery to aid the surgeon in the identification of malignant tissue. Particularly, dual-modality approaches combining radionuclide and near-infrared fluorescence (NIRF) imaging have shown promising results in preclinical studies. Radionuclide imaging allows sensitive intra-operative localization of tumor lesions using a gamma probe, whereas NIRF imaging allows more accurate real-time tumor delineation. Consequently, both radionuclide and NIRF imaging might complement each other, and dual-modality image-guided surgery may overcome limitations of the currently used single-modality imaging techniques. In this review, a comprehensive overview on recent preclinical advances in tumor-targeted radionuclide and fluorescence dual-modality imaging is provided. Subsequently, the clinical applicability of dual-modality image-guided surgery is discussed.

  4. Procedural guidance using advance imaging techniques for percutaneous edge-to-edge mitral valve repair.

    PubMed

    Quaife, Robert A; Salcedo, Ernesto E; Carroll, John D

    2014-02-01

    The complexity of structural heart disease interventions such as edge-to edge mitral valve repair requires integration of multiple highly technical imaging modalities. Real time imaging with 3-dimensional (3D) echocardiography is a relatively new technique that first, allows clear volumetric imaging of target structures such as the mitral valve for both pre-procedural diagnosis and planning in patients with degenerative or functional mitral valve regurgitation. Secondly it provides intra-procedural, real-time panoramic volumetric 3D view of structural heart disease targets that facilitates eye-hand coordination while manipulating devices within the heart. X-ray fluoroscopy and RT 3D TEE images are used in combination to display specific targets and movement of catheter based technologies in 3D space. This integration requires at least two different image display monitors and mentally fusing the individual datasets by the operator. Combined display technology such as this, allow rotation and orientation of both dataset perspectives necessary to define targets and guidance of structural disease device procedures. The inherently easy concept of direct visual feedback and eye-hand coordination allows safe and efficient completion of MitraClip procedures. This technology is now merged into a single structural heart disease guidance mode called EchoNavigator(TM) (Philips Medical Imaging Andover, MA). These advanced imaging techniques have revolutionized the field of structural heart disease interventions and this experience is exemplified by a cooperative imaging approach used for guidance of edge-to-edge mitral valve repair procedures.

  5. Advanced imaging techniques for assessment of structure, composition and function in biofilm systems.

    PubMed

    Neu, Thomas R; Manz, Bertram; Volke, Frank; Dynes, James J; Hitchcock, Adam P; Lawrence, John R

    2010-04-01

    Scientific imaging represents an important and accepted research tool for the analysis and understanding of complex natural systems. Apart from traditional microscopic techniques such as light and electron microscopy, new advanced techniques have been established including laser scanning microscopy (LSM), magnetic resonance imaging (MRI) and scanning transmission X-ray microscopy (STXM). These new techniques allow in situ analysis of the structure, composition, processes and dynamics of microbial communities. The three techniques open up quantitative analytical imaging possibilities that were, until a few years ago, impossible. The microscopic techniques represent powerful tools for examination of mixed environmental microbial communities usually encountered in the form of aggregates and films. As a consequence, LSM, MRI and STXM are being used in order to study complex microbial biofilm systems. This mini review provides a short outline of the more recent applications with the intention to stimulate new research and imaging approaches in microbiology.

  6. Single virus detection by means of atomic force microscopy in combination with advanced image analysis.

    PubMed

    Bocklitz, Thomas; Kämmer, Evelyn; Stöckel, Stephan; Cialla-May, Dana; Weber, Karina; Zell, Roland; Deckert, Volker; Popp, Jürgen

    2014-10-01

    In the present contribution virions of five different virus species, namely Varicella-zoster virus, Porcine teschovirus, Tobacco mosaic virus, Coliphage M13 and Enterobacteria phage PsP3, are investigated using atomic force microscopy (AFM). From the resulting height images quantitative features like maximal height, area and volume of the viruses could be extracted and compared to reference values. Subsequently, these features were accompanied by image moments, which quantify the morphology of the virions. Both types of features could be utilized for an automatic discrimination of the five virus species. The accuracy of this classification model was 96.8%. Thus, a virus detection on a single-particle level using AFM images is possible. Due to the application of advanced image analysis the morphology could be quantified and used for further analysis. Here, an automatic recognition by means of a classification model could be achieved in a reliable and objective manner. PMID:25196422

  7. Smaller, faster, brighter: advances in optical imaging of living plant cells.

    PubMed

    Shaw, Sidney L; Ehrhardt, David W

    2013-01-01

    The advent of fluorescent proteins and access to modern imaging technologies have dramatically accelerated the pace of discovery in plant cell biology. Remarkable new insights into such diverse areas as plant pathogenesis, cytoskeletal dynamics, sugar transport, cell wall synthesis, secretory control, and hormone signaling have come from careful examination of living cells using advanced optical probes. New technologies, both commercially available and on the horizon, promise a continued march toward more quantitative methods for imaging and for extending the optical exploration of biological structure and activity to molecular scales. In this review, we lay out fundamental issues in imaging plant specimens and look ahead to several technological innovations in molecular tools, instrumentation, imaging methods, and specimen handling that show promise for shaping the coming era of plant cell biology.

  8. Image navigation and registration performance assessment tool set for the GOES-R Advanced Baseline Imager and Geostationary Lightning Mapper

    NASA Astrophysics Data System (ADS)

    De Luccia, Frank J.; Houchin, Scott; Porter, Brian C.; Graybill, Justin; Haas, Evan; Johnson, Patrick D.; Isaacson, Peter J.; Reth, Alan D.

    2016-05-01

    The GOES-R Flight Project has developed an Image Navigation and Registration (INR) Performance Assessment Tool Set (IPATS) for measuring Advanced Baseline Imager (ABI) and Geostationary Lightning Mapper (GLM) INR performance metrics in the post-launch period for performance evaluation and long term monitoring. For ABI, these metrics are the 3-sigma errors in navigation (NAV), channel-to-channel registration (CCR), frame-to-frame registration (FFR), swath-to-swath registration (SSR), and within frame registration (WIFR) for the Level 1B image products. For GLM, the single metric of interest is the 3-sigma error in the navigation of background images (GLM NAV) used by the system to navigate lightning strikes. 3-sigma errors are estimates of the 99. 73rd percentile of the errors accumulated over a 24 hour data collection period. IPATS utilizes a modular algorithmic design to allow user selection of data processing sequences optimized for generation of each INR metric. This novel modular approach minimizes duplication of common processing elements, thereby maximizing code efficiency and speed. Fast processing is essential given the large number of sub-image registrations required to generate INR metrics for the many images produced over a 24 hour evaluation period. Another aspect of the IPATS design that vastly reduces execution time is the off-line propagation of Landsat based truth images to the fixed grid coordinates system for each of the three GOES-R satellite locations, operational East and West and initial checkout locations. This paper describes the algorithmic design and implementation of IPATS and provides preliminary test results.

  9. Image Navigation and Registration Performance Assessment Tool Set for the GOES-R Advanced Baseline Imager and Geostationary Lightning Mapper

    NASA Technical Reports Server (NTRS)

    De Luccia, Frank J.; Houchin, Scott; Porter, Brian C.; Graybill, Justin; Haas, Evan; Johnson, Patrick D.; Isaacson, Peter J.; Reth, Alan D.

    2016-01-01

    The GOES-R Flight Project has developed an Image Navigation and Registration (INR) Performance Assessment Tool Set (IPATS) for measuring Advanced Baseline Imager (ABI) and Geostationary Lightning Mapper (GLM) INR performance metrics in the post-launch period for performance evaluation and long term monitoring. For ABI, these metrics are the 3-sigma errors in navigation (NAV), channel-to-channel registration (CCR), frame-to-frame registration (FFR), swath-to-swath registration (SSR), and within frame registration (WIFR) for the Level 1B image products. For GLM, the single metric of interest is the 3-sigma error in the navigation of background images (GLM NAV) used by the system to navigate lightning strikes. 3-sigma errors are estimates of the 99.73rd percentile of the errors accumulated over a 24-hour data collection period. IPATS utilizes a modular algorithmic design to allow user selection of data processing sequences optimized for generation of each INR metric. This novel modular approach minimizes duplication of common processing elements, thereby maximizing code efficiency and speed. Fast processing is essential given the large number of sub-image registrations required to generate INR metrics for the many images produced over a 24-hour evaluation period. Another aspect of the IPATS design that vastly reduces execution time is the off-line propagation of Landsat based truth images to the fixed grid coordinates system for each of the three GOES-R satellite locations, operational East and West and initial checkout locations. This paper describes the algorithmic design and implementation of IPATS and provides preliminary test results.

  10. Advanced Remote-Sensing Imaging Emission Spectrometer (ARIES): AIRS Spectral Resolution with MODIS Spatial Resolution

    NASA Technical Reports Server (NTRS)

    Pagano, Thomas S.; Chahine, Moustafa T.; Aumann, Hartmut H.; OCallaghan, Fred

    2006-01-01

    The Advanced Remote-sensing Imaging Emission Spectrometer (ARIES) will measure a wide range of earth quantities fundamental to the study of global climate change. It will build upon the success of the Moderate Resolution Imaging Spectroradiometer (MODIS) and the Atmospheric Infrared Sounder (AIRS) instruments currently flying on the EOS Aqua Spacecraft. Both instruments are facility instruments for NASA providing data to thousands of scientists investigating land, ocean and atmospheric Earth System processes. ARIES will meet all the requirements of AIRS and MODIS in a single compact instrument, while providing the next-generation capability of improved spatial resolution for AIRS and improved spectral resolution for MODIS.

  11. Uncovering brain–heart information through advanced signal and image processing

    PubMed Central

    Toschi, Nicola; Barbieri, Riccardo

    2016-01-01

    Through their dynamical interplay, the brain and the heart ensure fundamental homeostasis and mediate a number of physiological functions as well as their disease-related aberrations. Although a vast number of ad hoc analytical and computational tools have been recently applied to the non-invasive characterization of brain and heart dynamic functioning, little attention has been devoted to combining information to unveil the interactions between these two physiological systems. This theme issue collects contributions from leading experts dealing with the development of advanced analytical and computational tools in the field of biomedical signal and image processing. It includes perspectives on recent advances in 7 T magnetic resonance imaging as well as electroencephalogram, electrocardiogram and cerebrovascular flow processing, with the specific aim of elucidating methods to uncover novel biological and physiological correlates of brain–heart physiology and physiopathology. PMID:27044995

  12. 37 CFR 201.22 - Advance notices of potential infringement of works consisting of sounds, images, or both.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... infringement of works consisting of sounds, images, or both. 201.22 Section 201.22 Patents, Trademarks, and... Advance notices of potential infringement of works consisting of sounds, images, or both. (a) Definitions... after the first fixation of a work consisting of sounds, images, or both that is first...

  13. 37 CFR 201.22 - Advance notices of potential infringement of works consisting of sounds, images, or both.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... infringement of works consisting of sounds, images, or both. 201.22 Section 201.22 Patents, Trademarks, and... Advance notices of potential infringement of works consisting of sounds, images, or both. (a) Definitions... after the first fixation of a work consisting of sounds, images, or both that is first...

  14. 37 CFR 201.22 - Advance notices of potential infringement of works consisting of sounds, images, or both.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... infringement of works consisting of sounds, images, or both. 201.22 Section 201.22 Patents, Trademarks, and... Advance notices of potential infringement of works consisting of sounds, images, or both. (a) Definitions... after the first fixation of a work consisting of sounds, images, or both that is first...

  15. 37 CFR 201.22 - Advance notices of potential infringement of works consisting of sounds, images, or both.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... infringement of works consisting of sounds, images, or both. 201.22 Section 201.22 Patents, Trademarks, and... § 201.22 Advance notices of potential infringement of works consisting of sounds, images, or both. (a... after the first fixation of a work consisting of sounds, images, or both that is first...

  16. Recent Advances in 19Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions

    PubMed Central

    Schmieder, Anne H.; Caruthers, Shelton D.; Keupp, Jochen; Wickline, Samuel A.; Lanza, Gregory M.

    2016-01-01

    The research roots of 19fluorine (19F) magnetic resonance imaging (MRI) date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded. In part, this is due to advances in MRI instrumentation, 19F/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of 19F into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents. PMID:27110430

  17. A Novel Murine Model for Localized Radiation Necrosis and its Characterization Using Advanced Magnetic Resonance Imaging

    SciTech Connect

    Jost, Sarah C.; Hope, Andrew; Kiehl, Erich; Perry, Arie; Travers, Sarah; Garbow, Joel R.

    2009-10-01

    Purpose: To develop a murine model of radiation necrosis using fractionated, subtotal cranial irradiation; and to investigate the imaging signature of radiation-induced tissue damage using advanced magnetic resonance imaging techniques. Methods and Materials: Twenty-four mice each received 60 Gy of hemispheric (left) irradiation in 10 equal fractions. Magnetic resonance images at 4.7 T were subsequently collected using T1-, T2-, and diffusion sequences at selected time points after irradiation. After imaging, animals were killed and their brains fixed for correlative histologic analysis. Results: Contrast-enhanced T1- and T2-weighted magnetic resonance images at months 2, 3, and 4 showed changes consistent with progressive radiation necrosis. Quantitatively, mean diffusivity was significantly higher (mean = 0.86, 1.13, and 1.24 {mu}m{sup 2}/ms at 2, 3, and 4 months, respectively) in radiated brain, compared with contralateral untreated brain tissue (mean = 0.78, 0.82, and 0.83 {mu}m{sup 2}/ms) (p < 0.0001). Histology reflected changes typically seen in radiation necrosis. Conclusions: This murine model of radiation necrosis will facilitate investigation of imaging biomarkers that distinguish between radiation necrosis and tumor recurrence. In addition, this preclinical study supports clinical data suggesting that diffusion-weighted imaging may be helpful in answering this diagnostic question in clinical settings.

  18. Advancing Patient-centered Outcomes in Emergency Diagnostic Imaging: A Research Agenda.

    PubMed

    Kanzaria, Hemal K; McCabe, Aileen M; Meisel, Zachary M; LeBlanc, Annie; Schaffer, Jason T; Bellolio, M Fernanda; Vaughan, William; Merck, Lisa H; Applegate, Kimberly E; Hollander, Judd E; Grudzen, Corita R; Mills, Angela M; Carpenter, Christopher R; Hess, Erik P

    2015-12-01

    Diagnostic imaging is integral to the evaluation of many emergency department (ED) patients. However, relatively little effort has been devoted to patient-centered outcomes research (PCOR) in emergency diagnostic imaging. This article provides background on this topic and the conclusions of the 2015 Academic Emergency Medicine consensus conference PCOR work group regarding "Diagnostic Imaging in the Emergency Department: A Research Agenda to Optimize Utilization." The goal was to determine a prioritized research agenda to establish which outcomes related to emergency diagnostic imaging are most important to patients, caregivers, and other key stakeholders and which methods will most optimally engage patients in the decision to undergo imaging. Case vignettes are used to emphasize these concepts as they relate to a patient's decision to seek care at an ED and the care received there. The authors discuss applicable research methods and approaches such as shared decision-making that could facilitate better integration of patient-centered outcomes and patient-reported outcomes into decisions regarding emergency diagnostic imaging. Finally, based on a modified Delphi process involving members of the PCOR work group, prioritized research questions are proposed to advance the science of patient-centered outcomes in ED diagnostic imaging. PMID:26574729

  19. [Image guided and robotic treatment--the advance of cybernetics in clinical medicine].

    PubMed

    Fosse, E; Elle, O J; Samset, E; Johansen, M; Røtnes, J S; Tønnessen, T I; Edwin, B

    2000-01-10

    The introduction of advanced technology in hospitals has changed the treatment practice towards more image guided and minimal invasive procedures. Modern computer and communication technology opens up for robot aided and pre-programmed intervention. Several robotic systems are in clinical use today both in microsurgery and in major cardiac and orthopedic operations. As this trend develops, professions which are new in this context such as physicists, mathematicians and cybernetic engineers will be increasingly important in the treatment of patients.

  20. Recent advances in MRI technology: Implications for image quality and patient safety

    PubMed Central

    Sobol, Wlad T.

    2012-01-01

    Recent advances in MRI technology are presented, with emphasis on how this new technology impacts clinical operations (better image quality, faster exam times, and improved throughput). In addition, implications for patient safety are discussed with emphasis on the risk of patient injury due to either high local specific absorption rate (SAR) or large cumulative energy doses delivered during long exam times. Patient comfort issues are examined as well. PMID:23961024

  1. Important advances in technology and unique applications related to cardiac magnetic resonance imaging.

    PubMed

    Ghosn, Mohamad G; Shah, Dipan J

    2014-01-01

    Cardiac magnetic resonance has become a well-established imaging modality and is considered the gold standard for myocardial tissue viability assessment and ventricular volumes quantification. Recent technological hardware and software advancements in magnetic resonance imaging technology have allowed the development of new methods that can improve clinical cardiovascular diagnosis and prognosis. The advent of a new generation of higher magnetic field scanners can be beneficial to various clinical applications. Also, the development of faster acquisition techniques have allowed mapping of the magnetic relaxation properties T1, T2, and T2* in the myocardium that can be used to quantify myocardial diffuse fibrosis, determine the presence of edema or inflammation, and measure iron within the myocardium, respectively. Another recent major advancement in CMR has been the introduction of three-dimension (3D) phase contrast imaging, also known as 4D flow. The following review discusses key advances in cardiac magnetic resonance technology and their potential to improve clinical cardiovascular diagnosis and outcomes. PMID:25574343

  2. Important advances in technology and unique applications related to cardiac magnetic resonance imaging.

    PubMed

    Ghosn, Mohamad G; Shah, Dipan J

    2014-01-01

    Cardiac magnetic resonance has become a well-established imaging modality and is considered the gold standard for myocardial tissue viability assessment and ventricular volumes quantification. Recent technological hardware and software advancements in magnetic resonance imaging technology have allowed the development of new methods that can improve clinical cardiovascular diagnosis and prognosis. The advent of a new generation of higher magnetic field scanners can be beneficial to various clinical applications. Also, the development of faster acquisition techniques have allowed mapping of the magnetic relaxation properties T1, T2, and T2* in the myocardium that can be used to quantify myocardial diffuse fibrosis, determine the presence of edema or inflammation, and measure iron within the myocardium, respectively. Another recent major advancement in CMR has been the introduction of three-dimension (3D) phase contrast imaging, also known as 4D flow. The following review discusses key advances in cardiac magnetic resonance technology and their potential to improve clinical cardiovascular diagnosis and outcomes.

  3. Advanced Image Intensifier: a 60°field-of-view night vision system with integral electroluminescent display

    NASA Astrophysics Data System (ADS)

    Crenshaw, David A.; Branigan, Robert G.

    1996-06-01

    The Advanced Image Intensifier Advanced Technology Demonstrator is an Army program to develop and demonstrate the next generation of night vision goggle using revolutionary new technologies to improve system performance and expand the capability of currently fielded image intensifier devices. The Advanced Image Intensifier is a helmet mounted imaging and display system that exploits recent advances in diffractive optics, miniature flat panel displays, image intensifier tube technology and manufacturing processes. The system will demonstrate significantly enhanced operational performance by increasing low-light resolution by greater than 25 percent; increasing field of view from 40 degrees to 60 degrees; improving high light performance; and integrating a display for viewing thermal imagery, computer graphics, and symbology. The results of these improvements will increase the night fighting capability, operational effectiveness, mobilty, versatility, and survivability of the dismounted soldier and aviator.

  4. Three-Dimensional Imaging and Image Displays: Surgical Application of Advanced Technologies.

    PubMed

    Satava

    1996-09-01

    One of the cornerstones of modern technology that was ushered in by laparoscopic surgery is the use of the video image. The importance of this "virtual representation" of the patient goes well beyond the application to laparoscopic surgery, and lies at the very heart of the revolution of surgery into the Information Age. Real objects, organs and patients can be represented as 2 and 3-dimensional computer generated images and viewed upon displays beyond the simple video monitor which permit a level of clinical practice not possible on the actual patients. These fundamental concepts that form the foundation of the revolution in surgery are placed in a framework for the future of surgery, and illustrate how their implementation can dramatically improve patient care.

  5. Comparison of two imaging programs in predicting the soft tissue changes with mandibular advancement surgery.

    PubMed

    Ravindranath, Sneha; Krishnaswamy, Nathamuni Rengarajan; Sundaram, Venkateswaran

    2011-01-01

    Establishing common objectives and expectations concerning the outcome of proposed surgical orthodontic therapy is a crucial part of the treatment planning process, which has been greatly simplified by imaging software. The purpose of this study was to investigate the reliability of two surgical imaging programs--Dolphin Imaging 10 and Vistadent OC--in simulating the actual outcome of mandibular advancement surgery by using a visual analog scale (VAS) judged by a panel of orthodontists, oral surgeons, and laypersons. The predictions were also analyzed with soft tissue cephalometric evaluation. The results of the study showed that in predicting the surgical outcome evaluated by the VAS, both programs received a mean rating of fair. One was marginally superior for the overall assessment among all three panelist groups. Region-wise, rating indicated the lower lip region to be the least accurate, and the submental region received the highest scores. The soft tissue cephalometric parameters showed minimal differences except for the lower lip parameters. Thus, Dolphin Imaging 10 and Vistadent OC are reliable in predicting mandibular advancement surgical outcomes with inaccuracies chiefly in the lower lip region. PMID:22299108

  6. Advanced contrast nanoagents for photoacoustic molecular imaging, cytometry, blood test and photothermal theranostics†

    PubMed Central

    de la Zerda, Adam; Kim, Jin-Woo; Galanzha, Ekaterina I.; Gambhir, Sanjiv S.; Zharov, Vladimir P.

    2013-01-01

    Various nanoparticles have raised significant interest over the past decades for their unique physical and optical properties and biological utilities. Here we summarize the vast applications of advanced nanoparticles with a focus on carbon nanotube (CNT)-based or CNT-catalyzed contrast agents for photoacoustic (PA) imaging, cytometry and theranostics applications based on the photothermal (PT) effect. We briefly review the safety and potential toxicity of the PA/PT contrast nanoagents, while showing how the physical properties as well as multiple biological coatings change their toxicity profiles and contrasts. We provide general guidelines needed for the validation of a new molecular imaging agent in living subjects, and exemplify these guidelines with single-walled CNTs targeted to αvβ3, an integrin associated with tumor angiogenesis, and golden carbon nanotubes targeted to LYVE-1, endothelial lymphatic receptors. An extensive review of the potential applications of advanced contrast agents is provided, including imaging of static targets such as tumor angiogenesis receptors, in vivo cytometry of dynamic targets such as circulating tumor cells and nanoparticles in blood, lymph, bones and plants, methods to enhance the PA and PT effects with transient and stationary bubble conjugates, PT/PA Raman imaging and multispectral histology. Finally, theranostic applications are reviewed, including the nanophotothermolysis of individual tumor cells and bacteria with clustered nanoparticles, nanothrombolysis of blood clots, detection and purging metastasis in sentinel lymph nodes, spectral hole burning and multiplex therapy with ultrasharp rainbow nanoparticles. PMID:22025336

  7. A standard data set for performance analysis of advanced IR image processing techniques

    NASA Astrophysics Data System (ADS)

    Weiß, A. Robert; Adomeit, Uwe; Chevalier, Philippe; Landeau, Stéphane; Bijl, Piet; Champagnat, Frédéric; Dijk, Judith; Göhler, Benjamin; Landini, Stefano; Reynolds, Joseph P.; Smith, Leslie N.

    2012-06-01

    Modern IR cameras are increasingly equipped with built-in advanced (often non-linear) image and signal processing algorithms (like fusion, super-resolution, dynamic range compression etc.) which can tremendously influence performance characteristics. Traditional approaches to range performance modeling are of limited use for these types of equipment. Several groups have tried to overcome this problem by producing a variety of imagery to assess the impact of advanced signal and image processing. Mostly, this data was taken from classified targets and/ or using classified imager and is thus not suitable for comparison studies between different groups from government, industry and universities. To ameliorate this situation, NATO SET-140 has undertaken a systematic measurement campaign at the DGA technical proving ground in Angers, France, to produce an openly distributable data set suitable for the assessment of fusion, super-resolution, local contrast enhancement, dynamic range compression and image-based NUC algorithm performance. The imagery was recorded for different target / background settings, camera and/or object movements and temperature contrasts. MWIR, LWIR and Dual-band cameras were used for recording and were also thoroughly characterized in the lab. We present a selection of the data set together with examples of their use in the assessment of super-resolution and contrast enhancement algorithms.

  8. A review of breast tomosynthesis. Part II. Image reconstruction, processing and analysis, and advanced applications.

    PubMed

    Sechopoulos, Ioannis

    2013-01-01

    Many important post-acquisition aspects of breast tomosynthesis imaging can impact its clinical performance. Chief among them is the reconstruction algorithm that generates the representation of the three-dimensional breast volume from the acquired projections. But even after reconstruction, additional processes, such as artifact reduction algorithms, computer aided detection and diagnosis, among others, can also impact the performance of breast tomosynthesis in the clinical realm. In this two part paper, a review of breast tomosynthesis research is performed, with an emphasis on its medical physics aspects. In the companion paper, the first part of this review, the research performed relevant to the image acquisition process is examined. This second part will review the research on the post-acquisition aspects, including reconstruction, image processing, and analysis, as well as the advanced applications being investigated for breast tomosynthesis. PMID:23298127

  9. A review of breast tomosynthesis. Part II. Image reconstruction, processing and analysis, and advanced applications

    PubMed Central

    Sechopoulos, Ioannis

    2013-01-01

    Many important post-acquisition aspects of breast tomosynthesis imaging can impact its clinical performance. Chief among them is the reconstruction algorithm that generates the representation of the three-dimensional breast volume from the acquired projections. But even after reconstruction, additional processes, such as artifact reduction algorithms, computer aided detection and diagnosis, among others, can also impact the performance of breast tomosynthesis in the clinical realm. In this two part paper, a review of breast tomosynthesis research is performed, with an emphasis on its medical physics aspects. In the companion paper, the first part of this review, the research performed relevant to the image acquisition process is examined. This second part will review the research on the post-acquisition aspects, including reconstruction, image processing, and analysis, as well as the advanced applications being investigated for breast tomosynthesis. PMID:23298127

  10. Recent advancements in structured-illumination microscopy toward live-cell imaging.

    PubMed

    Hirano, Yasuhiro; Matsuda, Atsushi; Hiraoka, Yasushi

    2015-08-01

    Fluorescence microscopy allows us to observe fluorescently labeled molecules in diverse biological processes and organelle structures within living cells. However, the diffraction limit restricts its spatial resolution to about half of its wavelength, limiting the capability of biological observation at the molecular level. Structured-illumination microscopy (SIM), a type of super-resolution microscopy, doubles the spatial resolution in all three dimensions by illuminating the sample with a patterned excitation light, followed by computer reconstruction. SIM uses a relatively low illumination power compared with other methods of super-resolution microscopy and is easily available for multicolor imaging. SIM has great potential for meeting the requirements of live-cell imaging. Recent developments in diverse types of SIM have achieved higher spatial (∼50 nm lateral) and temporal (∼100 Hz) resolutions. Here, we review recent advancements in SIM and discuss its application in noninvasive live-cell imaging. PMID:26133185

  11. Advanced image processing package for FPGA-based re-programmable miniature electronics

    NASA Astrophysics Data System (ADS)

    Ovod, Vladimir I.; Baxter, Christopher R.; Massie, Mark A.; McCarley, Paul L.

    2005-05-01

    Nova Sensors produces miniature electronics for a variety of real-time digital video camera systems, including foveal sensors based on Nova's Variable Acuity Superpixel Imager (VASITM) technology. An advanced image-processing package has been designed at Nova Sensors to re-configure the FPGA-based co-processor board for numerous applications including motion detection, optical, background velocimetry and target tracking. Currently, the processing package consists of 14 processing operations that cover a broad range of point- and area-applied algorithms. Flexible FPGA designs of these operations and re-programmability of the processing board allows for easy updates of the VASITM sensors, and for low-cost customization of VASITM sensors taking into account specific customer requirements. This paper describes the image processing algorithms implemented and verified in Xilinx FPGAs and provides the major technical performances with figures illustrating practical applications of the processing package.

  12. Recent Advances in the Imaging Diagnosis of Hepatocellular Carcinoma: Value of Gadoxetic Acid-Enhanced MRI

    PubMed Central

    Joo, Ijin; Lee, Jeong Min

    2016-01-01

    Magnetic resonance imaging (MRI) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DPTA), or gadoxetic acid for short, is a hepatocyte-specific contrast agent which is now increasingly used for the detection and characterization of focal hepatic lesions, particularly in patients at high-risk of developing hepatocellular carcinomas (HCC). In fact, several recent guidelines now recognize gadoxetic acid-enhanced MRI (Gd-EOB-MRI) as the primary diagnostic imaging modality for the noninvasive diagnosis of HCC, although it must be noted that several major guidelines still include only extracellular contrast media-enhanced computed tomography and MRI. The primary merits of Gd-EOB-MRI lie in the fact that it can provide not only dynamic imaging, but also hepatobiliary phase (HBP) imaging which can lead to high lesion-to-liver contrast and give additional information regarding hepatocyte uptake via organic anion transporting polypeptides. This, in turn, allows higher sensitivity in detecting small HCCs and helps provide additional information regarding the multistep process of hepatocarcinogenesis. Indeed, many recent studies have investigated the diagnostic value of Gd-EOB-MRI for early HCCs as well as its role as a potential imaging biomarker in predicting outcome. We herein review the recent advances in the imaging diagnosis of HCCs focusing on the applications of Gd-EOB-MRI and the challenging issues that remain. PMID:26989660

  13. Technologies of image guidance and the development of advanced linear accelerator systems for radiotherapy.

    PubMed

    Wu, Vincent W C; Law, Maria Y Y; Star-Lack, Josh; Cheung, Fion W K; Ling, C Clifton

    2011-01-01

    As advanced radiotherapy approaches for targeting the tumor and sparing the normal tissues have been developed, the image guidance of therapy has become essential to directing and confirming treatment accuracy. To approach these goals, image guidance devices now include kV on-board imagers, kV/MV cone-beam CT systems, CT-on-rails, and mobile and in-room radiographic/fluoroscopic systems. Nonionizing sources, such as ultrasound and optical systems, and electromagnetic devices have been introduced to monitor or track the patient and/or tumor positions during treatment. In addition, devices have been designed specifically for monitoring and/or controlling respiratory motion. Optimally, image-guided radiation therapy systems should possess 3 essential elements: (1) 3D imaging of soft tissues and tumors, (2) efficient acquisition and comparison of the 3D images, and (3) an efficacious process for clinically meaningful intervention. Understanding and using these tools effectively is central to current radiotherapy practice. The implementation and integration of these devices continue to carry practical challenges, which emphasize the need for further development of the technologies and their clinical applications.

  14. Advanced imaging techniques in the therapeutic response of transarterial chemoembolization for hepatocellular carcinoma

    PubMed Central

    Yang, Ke; Zhang, Xiao-Ming; Yang, Lin; Xu, Hao; Peng, Juan

    2016-01-01

    Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transarterial chemoembolization (TACE) can significantly improve the survival rate of patients with HCC and is the first treatment choice for patients who are not suitable for surgical resections. The evaluation of the response to TACE treatment affects not only the assessment of the therapy efficacy but also the development of the next step in the treatment plan. The use of imaging to examine changes in tumor volume to assess the response of solid tumors to treatment has been controversial. In recent years, the emergence of new imaging technology has made it possible to observe the response of tumors to treatment prior to any morphological changes. In this article, the advances in studies reporting the use of computed tomography perfusion imaging, diffusion-weighted magnetic resonance imaging (MRI), intravoxel incoherent motion, diffusion kurtosis imaging, magnetic resonance spectroscopy, magnetic resonance perfusion-weighted imaging, blood oxygen level-dependent MRI, positron emission tomography (PET)/computed tomography and PET/MRI to assess the TACE treatment response are reviewed. PMID:27239110

  15. Recent Advances in the Imaging Diagnosis of Hepatocellular Carcinoma: Value of Gadoxetic Acid-Enhanced MRI.

    PubMed

    Joo, Ijin; Lee, Jeong Min

    2016-02-01

    Magnetic resonance imaging (MRI) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DPTA), or gadoxetic acid for short, is a hepatocyte-specific contrast agent which is now increasingly used for the detection and characterization of focal hepatic lesions, particularly in patients at high-risk of developing hepatocellular carcinomas (HCC). In fact, several recent guidelines now recognize gadoxetic acid-enhanced MRI (Gd-EOB-MRI) as the primary diagnostic imaging modality for the noninvasive diagnosis of HCC, although it must be noted that several major guidelines still include only extracellular contrast media-enhanced computed tomography and MRI. The primary merits of Gd-EOB-MRI lie in the fact that it can provide not only dynamic imaging, but also hepatobiliary phase (HBP) imaging which can lead to high lesion-to-liver contrast and give additional information regarding hepatocyte uptake via organic anion transporting polypeptides. This, in turn, allows higher sensitivity in detecting small HCCs and helps provide additional information regarding the multistep process of hepatocarcinogenesis. Indeed, many recent studies have investigated the diagnostic value of Gd-EOB-MRI for early HCCs as well as its role as a potential imaging biomarker in predicting outcome. We herein review the recent advances in the imaging diagnosis of HCCs focusing on the applications of Gd-EOB-MRI and the challenging issues that remain. PMID:26989660

  16. Recent Advances in the Diagnosis and Management of Cirrhosis-Associated Cardiomyopathy in Liver Transplant Candidates: Advanced Echo Imaging, Cardiac Biomarkers, and Advanced Heart Failure Therapies

    PubMed Central

    Farr, Maryjane; Schulze, Paul Christian

    2014-01-01

    Patients with end-stage liver disease in need of liver transplantation increasingly are older with a greater burden of cardiac disease and other co-morbidities, which may increase perioperative risk and adversely affect long-term prognosis. Cirrhosis of any etiology manifests hemodynamically as a state of low systemic vascular resistance, with high peripheral, but low central blood volume, leading to a state of neurohormonal activation and high cardiac output, which may adversely affect cardiac reserve under extreme perioperative stress, aptly termed cirrhosis-associated or cirrhotic cardiomyopathy. Evidence of asymptomatic cirrhotic cardiomyopathy may be found in subtle electrocardiographic and echocardiographic changes, but may progress to severe heart failure under the demands of bleeding and transfusions, vasopressors, rebounding peripheral vascular resistance, withdrawal of cardioprotective beta-blockers and mineralocorticoid antagonists, exacerbated by sepsis or systemic inflammatory response syndrome. This review will add to the current body of literature on cirrhotic cardiomyopathy by focusing on the role of advanced echocardiographic imaging techniques, cardiac biomarkers, and advanced heart failure therapies available to manage patients with cirrhotic cardiomyopathy while waiting for liver transplant and during the perioperative period. PMID:25657603

  17. Advances in functional and structural imaging of the human lung using proton MRI.

    PubMed

    Miller, G Wilson; Mugler, John P; Sá, Rui C; Altes, Talissa A; Prisk, G Kim; Hopkins, Susan R

    2014-12-01

    The field of proton lung MRI is advancing on a variety of fronts. In the realm of functional imaging, it is now possible to use arterial spin labeling (ASL) and oxygen-enhanced imaging techniques to quantify regional perfusion and ventilation, respectively, in standard units of measurement. By combining these techniques into a single scan, it is also possible to quantify the local ventilation-perfusion ratio, which is the most important determinant of gas-exchange efficiency in the lung. To demonstrate potential for accurate and meaningful measurements of lung function, this technique was used to study gravitational gradients of ventilation, perfusion, and ventilation-perfusion ratio in healthy subjects, yielding quantitative results consistent with expected regional variations. Such techniques can also be applied in the time domain, providing new tools for studying temporal dynamics of lung function. Temporal ASL measurements showed increased spatial-temporal heterogeneity of pulmonary blood flow in healthy subjects exposed to hypoxia, suggesting sensitivity to active control mechanisms such as hypoxic pulmonary vasoconstriction, and illustrating that to fully examine the factors that govern lung function it is necessary to consider temporal as well as spatial variability. Further development to increase spatial coverage and improve robustness would enhance the clinical applicability of these new functional imaging tools. In the realm of structural imaging, pulse sequence techniques such as ultrashort echo-time radial k-space acquisition, ultrafast steady-state free precession, and imaging-based diaphragm triggering can be combined to overcome the significant challenges associated with proton MRI in the lung, enabling high-quality three-dimensional imaging of the whole lung in a clinically reasonable scan time. Images of healthy and cystic fibrosis subjects using these techniques demonstrate substantial promise for non-contrast pulmonary angiography and detailed

  18. Recent advances in cross-sectional renal imaging-an oncologic perspective: the current concepts and the future challenges.

    PubMed

    Ganeshan, Dhakshinamoorthy; Notohamiprodjo, Mike; Nikolaidis, Paul; Sanyal, Rupan; Bhosale, Priya

    2013-01-01

    Renal imaging remains a critical tool to differentiate and manage benign from malignant renal disorders. Conventional multidetector computed tomography (CT) and magnetic resonance (MR) provide great anatomical details, although lack functional information and specificity. The lack of resolution undermines the functional capabilities of nuclear medicine imaging. Functional MR imaging has shown strong utility in imaging of renal masses, with evolving techniques such as diffusion, perfusion, and blood oxygen level-dependent sequences. At the same time, newer techniques like dual-energy CT and CT perfusion are also showing promise in renal oncologic imaging.This article will discuss the recent advances in MR imaging and CT techniques pertaining to renal oncological applications.

  19. Advanced Nurse Practitioner Educational Needs for Safe and Efficient Radiological Imaging.

    PubMed

    Logsdon, Roberta; Gleason, Robyn

    2015-01-01

    This study evaluated perceived knowledge and educational preparedness of advanced practice nurses (APNs) in the area of radiological imaging, including awareness and utilization of the American College of Radiology Appropriateness Criteria (ACR-AC). Previous studies have found a need for further education in radiological imaging for medical students, residents, and hospitalists; however, little to no research has been done to assess such knowledge and educational preparedness among APNs. An e-mail link to a researcher-developed questionnaire was sent to Florida licensed APNs. Statistical analysis used descriptive, parametric, and nonparametric methods including frequencies, percentages, and Mann-Whitney U statistics. Florida licensed APNs (n = 905) from 175 educational programs and 10 specialty areas responded to the questionnaire; 75.9% (n = 681) had never heard of the ACR-AC. Years of experience and training in acute care specialties increased perceived competency in ordering radiological tests. Results among APNs were similar to those reported from physician studies, and 92.3% of respondents (n = 829) stated that additional APN imaging education would be beneficial. These findings highlight the importance of incorporating more radiological imaging information into APN education, which could lead to a reduction in overall costs and improvement in perceived competence and knowledge of appropriate imaging utilization. PMID:26218489

  20. [Study on the advanced Schwarzschild imaging spectrometer with high resolution in broadband].

    PubMed

    Liu, Jian-Fang

    2013-08-01

    The Schwarzschild optical structure was studied for the application of imaging spectrometer. The perfect astigmatism-corrected condition was obtained based on the analysis of the astigmatism of the Schwarzschild structure. The structure was advanced in the paper. The Schwarzschild imaging spectrum system is composed of two Schwarzschild structures, which are the collimating mirror-convex mirror and the convex mirror-focusing mirror. The calculation was given to present the parameters of the imaging spectrum system. An example of the imaging spectrum system in the waveband of 340-500 nm was designed and proved our design theory. The solution of the initial optimum structure was designed by our theory and simulated. A system with NA 1.25, of which the modulation transfer functions (MTF) of all fields of view are more than 0.58 in the waveband in the required Nyquist frequency (20 lp x mm(-1)), is presented in the paper. The form of the design structure can be changed as C-T system, Ebert-Fastie system and Offner system. The result also certificated that the optical system theory can be applied to the small scale imaging spectrometer with high resolution and spectral broadband.

  1. Advanced spatio-temporal filtering techniques for photogrammetric image sequence analysis in civil engineering material testing

    NASA Astrophysics Data System (ADS)

    Liebold, F.; Maas, H.-G.

    2016-01-01

    The paper shows advanced spatial, temporal and spatio-temporal filtering techniques which may be used to reduce noise effects in photogrammetric image sequence analysis tasks and tools. As a practical example, the techniques are validated in a photogrammetric spatio-temporal crack detection and analysis tool applied in load tests in civil engineering material testing. The load test technique is based on monocular image sequences of a test object under varying load conditions. The first image of a sequence is defined as a reference image under zero load, wherein interest points are determined and connected in a triangular irregular network structure. For each epoch, these triangles are compared to the reference image triangles to search for deformations. The result of the feature point tracking and triangle comparison process is a spatio-temporally resolved strain value field, wherein cracks can be detected, located and measured via local discrepancies. The strains can be visualized as a color-coded map. In order to improve the measuring system and to reduce noise, the strain values of each triangle must be treated in a filtering process. The paper shows the results of various filter techniques in the spatial and in the temporal domain as well as spatio-temporal filtering techniques applied to these data. The best results were obtained by a bilateral filter in the spatial domain and by a spatio-temporal EOF (empirical orthogonal function) filtering technique.

  2. [Study on the Advanced Czerny-Turner Imaging Spectrometer with High Resolution in Broadband].

    PubMed

    Yan, Ling-wei

    2015-06-01

    This paper studies the Czerny-Turner optical structure which is used for the application in imaging spectrometers. To obtain the perfect astigmatism-corrected condition, the Czerny-Turner system has been analyzed and advanced. The basic structure of optical system is still as the traditional form which is composed by the spherical collimating mirror, the plane grating and the spherical focusing mirror. However, an off-the-shelf cylindrical lens is added after the focusing mirror to remove astigmatism differences between the tangential direction and the sagittaI direction. It makes the advanced optical system presents high resolution over the full bandwidth and decreases the cost. An example of the imaging spectrum system in the waveband of 380-760 nm has been designed to prove our theory. A system owns that NA equals to 0.05, and the modulation transfer functions (MTF) of all fields of view are more than 0.59 over the broadband under the required Nyquist frequency (20 lp x mm(-1)). It certificates that the optical system theory can be applied to the small scale imaging spectrometer with high resolution in spectral broadband.

  3. [Study on the Advanced Czerny-Turner Imaging Spectrometer with High Resolution in Broadband].

    PubMed

    Yan, Ling-wei

    2015-06-01

    This paper studies the Czerny-Turner optical structure which is used for the application in imaging spectrometers. To obtain the perfect astigmatism-corrected condition, the Czerny-Turner system has been analyzed and advanced. The basic structure of optical system is still as the traditional form which is composed by the spherical collimating mirror, the plane grating and the spherical focusing mirror. However, an off-the-shelf cylindrical lens is added after the focusing mirror to remove astigmatism differences between the tangential direction and the sagittaI direction. It makes the advanced optical system presents high resolution over the full bandwidth and decreases the cost. An example of the imaging spectrum system in the waveband of 380-760 nm has been designed to prove our theory. A system owns that NA equals to 0.05, and the modulation transfer functions (MTF) of all fields of view are more than 0.59 over the broadband under the required Nyquist frequency (20 lp x mm(-1)). It certificates that the optical system theory can be applied to the small scale imaging spectrometer with high resolution in spectral broadband. PMID:26601404

  4. Screening for Body Image Dissatisfaction in Patients with Advanced Cancer: A Pilot Study

    PubMed Central

    Rhondali, Wadih; Chisholm, Gary B.; Filbet, Marilene; Kang, Duck-Hee; Hui, David; Cororve Fingeret, Michelle

    2015-01-01

    Abstract Background Cancer and its treatment can significantly affect appearance and body integrity. A number of studies have explored the impact of cancer and its treatment on body image, primarily in head and neck and breast cancer. The aim of this pilot study was to examine the construct of body image dissatisfaction and its measurement using a single question in patients with advanced cancer. Methods Outpatients with advanced cancer were recruited (n=81). Assessments included Body Image Scale (BIS), Appearance Schema Inventory (ASI-R), Edmonton Symptom Assessment System (ESAS) with a total symptom distress score (TSDS) and two subscales scores (physical distress [PHS] and psychological distress [PSS]), Hospital Anxiety Depression Scale (HADS), and one question assessing the overall appearance satisfaction from the Multidimensional Body-Self Relations Questionnaire (MBSRQ). We also asked patients to rate the body image changes importance compared with five symptoms (pain, fatigue, depression, insomnia, lack of appetite). Results Forty-seven (58%) patients had a BIS score >10 (body image dissatisfaction) with a median of 11 (first–third quartiles, Q1–Q3; 5–16) and a median ASI-R of 3.1 (Q1–Q3; 2.8–3.5). Sensitivity and specificity of ≤3 for body image dissatisfaction in the single overall appearance question using the BIS as a standard was 0.70 and 0.71, respectively. BIS score was significantly correlated with ASI-R (r=0.248; p=0.025), age (r=−0.225; p=0.043), HADS-A (r=0.522, p<0.001), HADS-D (r=0.422, p<0.001), PSS score (r=0.371, p=0.001), PHS score (r=0.356, p=0.001), TSDS score (r=0.416, p<0.001), and the overall appearance question (MBSRQ; r=−0.449, p<0.001). Conclusion Body image dissatisfaction was frequent and associated with symptom burden. A single item ≤3 has a sensitivity of 70% for body image satisfaction screening. PMID:25188590

  5. Advances in EEG: home video telemetry, high frequency oscillations and electrical source imaging.

    PubMed

    Patel, Anjla C; Thornton, Rachel C; Mitchell, Tejal N; Michell, Andrew W

    2016-10-01

    Over the last two decades, technological advances in electroencephalography (EEG) have allowed us to extend its clinical utility for the evaluation of patients with epilepsy. This article reviews three main areas in which substantial advances have been made in the diagnosis and pre-surgical planning of patients with epilepsy. Firstly, the development of small portable video-EEG systems have allowed some patients to record their attacks at home, thereby improving diagnosis, with consequent substantial healthcare and economic implications. Secondly, in specialist centres carrying out epilepsy surgery, there has been considerable interest in whether bursts of very high frequency EEG activity can help to determine the regions of the brain likely to be generating the seizures. Identification of these discharges, initially only recorded from intracranial electrodes, may thus allow better surgical planning and improve surgical outcomes. Finally we discuss the contribution of electrical source imaging in the pre-surgical evaluation of patients with focal epilepsy, and its prospects for the future.

  6. Advanced MR imaging of the placenta: Exploring the in utero placenta-brain connection.

    PubMed

    Andescavage, Nickie Niforatos; du Plessis, Adre; Limperopoulos, Catherine

    2015-03-01

    The placenta is a vital organ necessary for the healthy neurodevelopment of the fetus. Despite the known associations between placental dysfunction and neurologic impairment, there is a paucity of tools available to reliably assess in vivo placental health and function. Existing clinical tools for placental assessment remain insensitive in predicting and evaluating placental well-being. Advanced MRI techniques hold significant promise for the dynamic, non-invasive, real-time assessment of placental health and identification of early placental-based disorders. In this review, we summarize the available clinical tools for placental assessment, including ultrasound, Doppler, and conventional MRI. We then explore the emerging role of advanced placental MR imaging techniques for supporting the developing fetus and appraise the strengths and limitations of quantitative MRI in identifying early markers of placental dysfunction for improved pregnancy monitoring and fetal outcomes. PMID:25765905

  7. SU-E-QI-20: A Review of Advanced PET and CT Image Features for the Evaluation of Tumor Response

    SciTech Connect

    Lu, W

    2014-06-15

    Purpose: To review the literature in using quantitative PET and CT image features for the evaluation of tumor response. Methods: We reviewed and summarized more than fifty papers that use advanced, quantitative PET/CT image features for the evaluation of tumor response. We also discussed future works on extracting disease-specific features, combining multiple and complementary features in response modeling, delineating tumor in multimodality images, and exploring biological explanations of these advanced features. Results: Advanced PET image features considering spatial information, such as tumor volume, tumor shape, total glycolytic volume, histogram distance, and texture features (characterizing spatial distribution of FDG uptake) have been found more informative than the traditional SUVmax for the prediction of tumor response. Advanced CT features, including volumetric, attenuation, morphologic, structure, and texture descriptors, have also been found advantage over the traditional RECIST and WHO criteria in certain tumor types. Conclusions: Advanced, quantitative FDG PET/CT image features have been shown promising for the evaluation of tumor response. With the emerging multi-modality imaging performed at multiple time points for each patient, it becomes more important to analyze the serial images quantitatively, select and combine both complementary and contradictory information from various sources, for accurate and personalized evaluation of tumor response to therapy.

  8. What advances in microscopy are required for combined MRI and optical functional brain imaging? (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Kleinfeld, David

    2016-03-01

    This overview talk will focus on forward-looking scientific needs and physical limits to images of neuronal processes. The challenge in nervous systems is that the basic unit for "switching" events in the nervous system occurs on the one micrometer scale of synaptic spines, while computations involve communication between individual neurons across the full expanse of cortex, which is ten millimeters for mouse cortex. I will address hoped-for advances in optical microscopy, within the context of existing and proposed contrast mechanisms of neuronal function, that span the four orders of magnitude of length scales for neuronal processing

  9. Earth Observing-1 Advanced Land Imager: Dark Current and Noise Characterization and Anomalous Detectors

    NASA Technical Reports Server (NTRS)

    Mendenhall, J. A.

    2001-01-01

    The dark current and noise characteristics of the Earth Observing-1 Advanced Land Imager measured during ground calibration at MIT Lincoln Laboratory are presented. Data were collected for the nominal focal plane operating temperature of 220 K as well as supplemental operating temperatures (215 and 225 K). Dark current baseline values are provided, and noise characterization includes the evaluation of white, coherent, low frequency, and high frequency components. Finally, anomalous detectors, characterized by unusual dark current, noise, gain, or cross-talk properties are investigated.

  10. High-speed image transmission via the Advanced Communication Technology Satellite (ACTS)

    NASA Astrophysics Data System (ADS)

    Bazzill, Todd M.; Huang, H. K.; Thoma, George R.; Long, L. Rodney; Gill, Michael J.

    1996-05-01

    We are developing a wide area test bed network using the Advanced Communication Technology Satellite (ACTS) from NASA for high speed medical image transmission. The two test sites are the University of California, San Francisco, and the National Library of Medicine. The first phase of the test bed runs over a T1 link (1.544 Mbits/sec) using a Very Small Aperture Terminal. The second phase involves the High Data Rate Terminal via an ATM OC 3C (155 Mbits/sec) connection. This paper describes the experimental set up and some preliminary results from phase 1.

  11. Advances in quantitative nanoscale subsurface imaging by mode-synthesizing atomic force microscopy

    SciTech Connect

    Vitry, P.; Bourillot, E.; Plassard, C.; Lacroute, Y.; Lesniewska, E.; Tetard, L.

    2014-08-04

    This paper reports on advances toward quantitative non-destructive nanoscale subsurface investigation of a nanofabricated sample based on mode synthesizing atomic force microscopy with heterodyne detection, addressing the need to correlate the role of actuation frequencies of the probe f{sub p} and the sample f{sub s} with depth resolution for 3D tomography reconstruction. Here, by developing a simple model and validating the approach experimentally through the study of the nanofabricated calibration depth samples consisting of buried metallic patterns, we demonstrate avenues for quantitative nanoscale subsurface imaging. Our findings enable the reconstruction of the sample depth profile and allow high fidelity resolution of the buried nanostructures. Non-destructive quantitative nanoscale subsurface imaging offers great promise in the study of the structures and properties of complex systems at the nanoscale.

  12. Recent advances in chemical imaging technology for the detection of contaminants for food safety and security

    NASA Astrophysics Data System (ADS)

    Priore, Ryan J.; Olkhovyk, Oksana; Drauch, Amy; Treado, Patrick; Kim, Moon; Chao, Kaunglin

    2009-05-01

    The need for routine, non-destructive chemical screening of agricultural products is increasing due to the health hazards to animals and humans associated with intentional and unintentional contamination of foods. Melamine, an industrial additive used to increase flame retardation in the resin industry, has recently been used to increase the apparent protein content of animal feed, of infant formula, as well as powdered and liquid milk in the dairy industry. Such contaminants, even at regulated levels, pose serious health risks. Chemical imaging technology provides the ability to evaluate large volumes of agricultural products before reaching the consumer. In this presentation, recent advances in chemical imaging technology that exploit Raman, fluorescence and near-infrared (NIR) are presented for the detection of contaminants in agricultural products.

  13. Advanced data visualization and sensor fusion: Conversion of techniques from medical imaging to Earth science

    NASA Technical Reports Server (NTRS)

    Savage, Richard C.; Chen, Chin-Tu; Pelizzari, Charles; Ramanathan, Veerabhadran

    1993-01-01

    Hughes Aircraft Company and the University of Chicago propose to transfer existing medical imaging registration algorithms to the area of multi-sensor data fusion. The University of Chicago's algorithms have been successfully demonstrated to provide pixel by pixel comparison capability for medical sensors with different characteristics. The research will attempt to fuse GOES (Geostationary Operational Environmental Satellite), AVHRR (Advanced Very High Resolution Radiometer), and SSM/I (Special Sensor Microwave Imager) sensor data which will benefit a wide range of researchers. The algorithms will utilize data visualization and algorithm development tools created by Hughes in its EOSDIS (Earth Observation SystemData/Information System) prototyping. This will maximize the work on the fusion algorithms since support software (e.g. input/output routines) will already exist. The research will produce a portable software library with documentation for use by other researchers.

  14. Satellite Detection in AdvancedCamera for Surveys/Wide Field Channel Images

    NASA Astrophysics Data System (ADS)

    Borncamp, D.; Lim, Pey-Lian

    2016-01-01

    This document explains the process by which satellite trails can be found within individual chips of an Advanced Camera for Surveys (ACS) Wide Field Channel (WFC) image. Since satellites are transient and sporadic events, we used the Hubble Frontier Fields (HFF) dataset which is manually checked for satellite trails has been used as a truth set to verify that the method in this document does a complete job without a high false positive rate. This document also details the process of producing a mask that will update data quality information to inform users where the trail traverses the image and properly account for the affected pixels. Along with this document, the Python source code used to detect and mask satellite trails will be released to users with as a stand-alone product within the STSDAS acstools package.

  15. Advanced magnetic resonance imaging techniques in the preterm brain: methods and applications.

    PubMed

    Tao, Joshua D; Neil, Jeffrey J

    2014-01-01

    Brain development and brain injury in preterm infants are areas of active research. Magnetic resonance imaging (MRI), a non-invasive tool applicable to both animal models and human infants, provides a wealth of information on this process by bridging the gap between histology (available from animal studies) and developmental outcome (available from clinical studies). Moreover, MRI also offers information regarding diagnosis and prognosis in the clinical setting. Recent advances in MR methods - diffusion tensor imaging, volumetric segmentation, surface based analysis, functional MRI, and quantitative metrics - further increase the sophistication of information available regarding both brain structure and function. In this review, we discuss the basics of these newer methods as well as their application to the study of premature infants.

  16. A geometric performance assessment of the EO-1 advanced land imager

    USGS Publications Warehouse

    Storey, J.C.; Choate, M.J.; Meyer, D.J.

    2004-01-01

    The Earth Observing 1 (EO-1) Advanced Land Imager (ALI) demonstrates technology applicable to a successor system to the Landsat Thematic Mapper series. A study of the geometric performance characteristics of the ALI was conducted under the auspices of the EO-1 Science Validation Team. This study evaluated ALI performance with respect to absolute pointing knowledge, focal plane sensor chip assembly alignment, and band-to-band registration for purposes of comparing this new technology to the heritage Landsat systems. On-orbit geometric calibration procedures were developed that allowed the generation of ALI geometrically corrected products that compare favorably with their Landsat 7 counterparts with respect to absolute geodetic accuracy, internal image geometry, and band registration.

  17. Magnetic resonance imaging for planning intracavitary brachytherapy for the treatment of locally advanced cervical cancer.

    PubMed

    Oñate Miranda, M; Pinho, D F; Wardak, Z; Albuquerque, K; Pedrosa, I

    2016-01-01

    Cervical cancer is the third most common gynecological cancer. Its treatment depends on tumor staging at the time of diagnosis, and a combination of chemotherapy and radiotherapy is the treatment of choice in locally advanced cervical cancers. The combined use of external beam radiotherapy and brachytherapy increases survival in these patients. Brachytherapy enables a larger dose of radiation to be delivered to the tumor with less toxicity for neighboring tissues with less toxicity for neighboring tissues compared to the use of external beam radiotherapy alone. For years, brachytherapy was planned exclusively using computed tomography (CT). The recent incorporation of magnetic resonance imaging (MRI) provides essential information about the tumor and neighboring structures making possible to better define the target volumes. Nevertheless, MRI has limitations, some of which can be compensated for by fusing CT and MRI. Fusing the images from the two techniques ensures optimal planning by combining the advantages of each technique.

  18. [Advances in the research of laser Doppler perfusion imaging in burn wounds].

    PubMed

    Liu, Jing; Xu, Longshun; Hu, Dahai; Qu, Yi; Wang, Guodong; Wang, Hongtao

    2014-04-01

    Laser Doppler perfusion imaging (LDPI) works through the Doppler effect of light wave, and it could depict the blood flow value of the entire wound in two-dimensional image without contacting the detection site directly. In resent years, LDPI has been proved to be effective to evaluate healing potential of a wound, and to predict burn depth and scar formation. The accuracy of LDPI is higher than other traditional methods and technique. However, there are still many influencing factors for the clinical application of LDPI scanning. This paper presents a comprehensive overview of advances in the research of LDPI for clinical application in the care of burn wounds and influencing factors for accurate scanning. PMID:24989665

  19. Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods.

    PubMed

    Ahmed, Rafay; Oborski, Matthew J; Hwang, Misun; Lieberman, Frank S; Mountz, James M

    2014-01-01

    Malignant gliomas consist of glioblastomas, anaplastic astrocytomas, anaplastic oligodendrogliomas and anaplastic oligoastrocytomas, and some less common tumors such as anaplastic ependymomas and anaplastic gangliogliomas. Malignant gliomas have high morbidity and mortality. Even with optimal treatment, median survival is only 12-15 months for glioblastomas and 2-5 years for anaplastic gliomas. However, recent advances in imaging and quantitative analysis of image data have led to earlier diagnosis of tumors and tumor response to therapy, providing oncologists with a greater time window for therapy management. In addition, improved understanding of tumor biology, genetics, and resistance mechanisms has enhanced surgical techniques, chemotherapy methods, and radiotherapy administration. After proper diagnosis and institution of appropriate therapy, there is now a vital need for quantitative methods that can sensitively detect malignant glioma response to therapy at early follow-up times, when changes in management of nonresponders can have its greatest effect. Currently, response is largely evaluated by measuring magnetic resonance contrast and size change, but this approach does not take into account the key biologic steps that precede tumor size reduction. Molecular imaging is ideally suited to measuring early response by quantifying cellular metabolism, proliferation, and apoptosis, activities altered early in treatment. We expect that successful integration of quantitative imaging biomarker assessment into the early phase of clinical trials could provide a novel approach for testing new therapies, and importantly, for facilitating patient management, sparing patients from weeks or months of toxicity and ineffective treatment. This review will present an overview of epidemiology, molecular pathogenesis and current advances in diagnoses, and management of malignant gliomas.

  20. Advancements in Transmitters and Sensors for Biological Tissue Imaging in Magnetic Induction Tomography

    PubMed Central

    Zakaria, Zulkarnay; Rahim, Ruzairi Abdul; Mansor, Muhammad Saiful Badri; Yaacob, Sazali; Ayub, Nor Muzakkir Nor; Muji, Siti Zarina Mohd.; Rahiman, Mohd Hafiz Fazalul; Aman, Syed Mustafa Kamal Syed

    2012-01-01

    Magnetic Induction Tomography (MIT), which is also known as Electromagnetic Tomography (EMT) or Mutual Inductance Tomography, is among the imaging modalities of interest to many researchers around the world. This noninvasive modality applies an electromagnetic field and is sensitive to all three passive electromagnetic properties of a material that are conductivity, permittivity and permeability. MIT is categorized under the passive imaging family with an electrodeless technique through the use of excitation coils to induce an electromagnetic field in the material, which is then measured at the receiving side by sensors. The aim of this review is to discuss the challenges of the MIT technique and summarize the recent advancements in the transmitters and sensors, with a focus on applications in biological tissue imaging. It is hoped that this review will provide some valuable information on the MIT for those who have interest in this modality. The need of this knowledge may speed up the process of adopted of MIT as a medical imaging technology. PMID:22969341

  1. Advances in image-guided radiation therapy-the role of PET-CT

    SciTech Connect

    Heron, Dwight E. . E-mail: heronD2@upmc.edu; Smith, Ryan P.; Andrade, Regiane S.

    2006-04-01

    In the era of image-guided radiation therapy (IGRT), the greatest challenge remains target delineation, as the opportunity to maximize cures while simultaneously decreasing radiation dose to the surrounding normal tissues is to be realized. Over the last 2 decades, technological advances in radiographic imaging, biochemistry, and molecular biology have played an increasing role in radiation treatment planning, delivery, and evaluation of response. Previously, fluoroscopy formed the basis of radiation treatment planning. Beginning in the late 1980s, computed tomography (CT) has become the basis for modern radiation treatment planning and delivery, coincident with the rise of 3-dimensional conformal radiation therapy (3DCRT). Additionally, multi-modality anatomic imaging registration was the solution pursued to augment delineation of tumors and surrounding structures on CT-based treatment planning. Although these imaging modalities provide the customary anatomic details necessary for radiation treatment planning, they have limitations, including difficulty with identification of small tumor deposits, tumor extension, and distinction from scar tissues. To overcome these limitations, PET and, more recently, PET-CT have been innovative regarding the extent of disease appraisal, target delineation in the treatment planning, and assessment of therapy response. We review the role of functional imaging in IGRT as it reassures transformations on the field of radiation oncology. As we move toward the era of IGRT, the use of multi-modality imaging fusion, and the introduction of more sensitive and specific PET-CT tracers may further assist target definition. Furthermore, the potential to predict early outcome or even detect early recurrence of tumor, may allow for the tailoring of intervention in cancer patients. The convergence of a biological target volume, and perhaps multi-tracer tumor, molecular, and genetic profile tumors will probably be vital in cancer treatment

  2. In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma

    PubMed Central

    Philipp-Abbrederis, Kathrin; Herrmann, Ken; Knop, Stefan; Schottelius, Margret; Eiber, Matthias; Lückerath, Katharina; Pietschmann, Elke; Habringer, Stefan; Gerngroß, Carlos; Franke, Katharina; Rudelius, Martina; Schirbel, Andreas; Lapa, Constantin; Schwamborn, Kristina; Steidle, Sabine; Hartmann, Elena; Rosenwald, Andreas; Kropf, Saskia; Beer, Ambros J; Peschel, Christian; Einsele, Hermann; Buck, Andreas K; Schwaiger, Markus; Götze, Katharina; Wester, Hans-Jürgen; Keller, Ulrich

    2015-01-01

    CXCR4 is a G-protein-coupled receptor that mediates recruitment of blood cells toward its ligand SDF-1. In cancer, high CXCR4 expression is frequently associated with tumor dissemination and poor prognosis. We evaluated the novel CXCR4 probe [68Ga]Pentixafor for in vivo mapping of CXCR4 expression density in mice xenografted with human CXCR4-positive MM cell lines and patients with advanced MM by means of positron emission tomography (PET). [68Ga]Pentixafor PET provided images with excellent specificity and contrast. In 10 of 14 patients with advanced MM [68Ga]Pentixafor PET/CT scans revealed MM manifestations, whereas only nine of 14 standard [18F]fluorodeoxyglucose PET/CT scans were rated visually positive. Assessment of blood counts and standard CD34+ flow cytometry did not reveal significant blood count changes associated with tracer application. Based on these highly encouraging data on clinical PET imaging of CXCR4 expression in a cohort of MM patients, we conclude that [68Ga]Pentixafor PET opens a broad field for clinical investigations on CXCR4 expression and for CXCR4-directed therapeutic approaches in MM and other diseases. PMID:25736399

  3. Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging.

    PubMed

    Ju, Myeong Jin; Hong, Young-Joo; Makita, Shuichi; Lim, Yiheng; Kurokawa, Kazuhiro; Duan, Lian; Miura, Masahiro; Tang, Shuo; Yasuno, Yoshiaki

    2013-08-12

    An advanced version of Jones matrix optical coherence tomography (JMT) is demonstrated for Doppler and polarization sensitive imaging of the posterior eye. JMT is capable of providing localized flow tomography by Doppler detection and investigating the birefringence property of tissue through a three-dimensional (3-D) Jones matrix measurement. Owing to an incident polarization multiplexing scheme based on passive optical components, this system is stable, safe in a clinical environment, and cost effective. Since the properties of this version of JMT provide intrinsic compensation for system imperfection, the system is easy to calibrate. Compared with the previous version of JMT, this advanced JMT achieves a sufficiently long depth measurement range for clinical cases of posterior eye disease. Furthermore, a fine spectral shift compensation method based on the cross-correlation of calibration signals was devised for stabilizing the phase of OCT, which enables a high sensitivity Doppler OCT measurement. In addition, a new theory of JMT which integrates the Jones matrix measurement, Doppler measurement, and scattering measurement is presented. This theory enables a sensitivity-enhanced scattering OCT and high-sensitivity Doppler OCT. These new features enable the application of this system to clinical cases. A healthy subject and a geographic atrophy patient were measured in vivo, and simultaneous imaging of choroidal vasculature and birefringence structures are demonstrated.

  4. New Generation of High Resolution Ultrasonic Imaging Technique for Advanced Material Characterization: Review

    NASA Astrophysics Data System (ADS)

    Maev, R. Gr.

    The role of non-destructive material characterization and NDT is changing at a rapid rate, continuing to evolve alongside the dramatic development of novel techniques based on the principles of high-resolution imaging. The modern use of advanced optical, thermal, ultrasonic, laser-ultrasound, acoustic emission, vibration, electro-magnetic, and X-ray techniques, etc., as well as refined measurement and signal/data processing devices, allows for continuous generation of on-line information. As a result real-time process monitoring can be achieved, leading to the more effective and efficient control of numerous processes, greatly improving manufacturing as a whole. Indeed, concurrent quality inspection has become an attainable reality. With the advent of new materials for use in various structures, joints, and parts, however, innovative applications of modern NDT imaging techniques are necessary to monitor as many stages of manufacturing as possible. Simply put, intelligent advance manufacturing is impossible without actively integrating modern non-destructive evaluation into the production system.

  5. Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging.

    PubMed

    Ju, Myeong Jin; Hong, Young-Joo; Makita, Shuichi; Lim, Yiheng; Kurokawa, Kazuhiro; Duan, Lian; Miura, Masahiro; Tang, Shuo; Yasuno, Yoshiaki

    2013-08-12

    An advanced version of Jones matrix optical coherence tomography (JMT) is demonstrated for Doppler and polarization sensitive imaging of the posterior eye. JMT is capable of providing localized flow tomography by Doppler detection and investigating the birefringence property of tissue through a three-dimensional (3-D) Jones matrix measurement. Owing to an incident polarization multiplexing scheme based on passive optical components, this system is stable, safe in a clinical environment, and cost effective. Since the properties of this version of JMT provide intrinsic compensation for system imperfection, the system is easy to calibrate. Compared with the previous version of JMT, this advanced JMT achieves a sufficiently long depth measurement range for clinical cases of posterior eye disease. Furthermore, a fine spectral shift compensation method based on the cross-correlation of calibration signals was devised for stabilizing the phase of OCT, which enables a high sensitivity Doppler OCT measurement. In addition, a new theory of JMT which integrates the Jones matrix measurement, Doppler measurement, and scattering measurement is presented. This theory enables a sensitivity-enhanced scattering OCT and high-sensitivity Doppler OCT. These new features enable the application of this system to clinical cases. A healthy subject and a geographic atrophy patient were measured in vivo, and simultaneous imaging of choroidal vasculature and birefringence structures are demonstrated. PMID:23938857

  6. Pushing CT and MR Imaging to the Molecular Level for Studying the “Omics”: Current Challenges and Advancements

    PubMed Central

    Huang, Hsuan-Ming; Shih, Yi-Yu

    2014-01-01

    During the past decade, medical imaging has made the transition from anatomical imaging to functional and even molecular imaging. Such transition provides a great opportunity to begin the integration of imaging data and various levels of biological data. In particular, the integration of imaging data and multiomics data such as genomics, metabolomics, proteomics, and pharmacogenomics may open new avenues for predictive, preventive, and personalized medicine. However, to promote imaging-omics integration, the practical challenge of imaging techniques should be addressed. In this paper, we describe key challenges in two imaging techniques: computed tomography (CT) and magnetic resonance imaging (MRI) and then review existing technological advancements. Despite the fact that CT and MRI have different principles of image formation, both imaging techniques can provide high-resolution anatomical images while playing a more and more important role in providing molecular information. Such imaging techniques that enable single modality to image both the detailed anatomy and function of tissues and organs of the body will be beneficial in the imaging-omics field. PMID:24738056

  7. Advances in Bio-Optical Imaging for the Diagnosis of Early Oral Cancer

    PubMed Central

    Olivo, Malini; Bhuvaneswari, Ramaswamy; Keogh, Ivan

    2011-01-01

    Oral cancer is among the most common malignancies worldwide, therefore early detection and treatment is imperative. The 5-year survival rate has remained at a dismal 50% for the past several decades. The main reason for the poor survival rate is the fact that most of the oral cancers, despite the general accessibility of the oral cavity, are not diagnosed until the advanced stage. Early detection of the oral tumors and its precursor lesions may be the most effective means to improve clinical outcome and cure most patients. One of the emerging technologies is the use of non-invasive in vivo tissue imaging to capture the molecular changes at high-resolution to improve the detection capability of early stage disease. This review will discuss the use of optical probes and highlight the role of optical imaging such as autofluorescence, fluorescence diagnosis (FD), laser confocal endomicroscopy (LCE), surface enhanced Raman spectroscopy (SERS), optical coherence tomography (OCT) and confocal reflectance microscopy (CRM) in early oral cancer detection. FD is a promising method to differentiate cancerous lesions from benign, thus helping in the determination of adequate resolution of surgical resection margin. LCE offers in vivo cellular imaging of tissue structures from surface to subsurface layers and has demonstrated the potential to be used as a minimally invasive optical biopsy technique for early diagnosis of oral cancer lesions. SERS was able to differentiate between normal and oral cancer patients based on the spectra acquired from saliva of patients. OCT has been used to visualize the detailed histological features of the oral lesions with an imaging depth down to 2–3 mm. CRM is an optical tool to noninvasively image tissue with near histological resolution. These comprehensive diagnostic modalities can also be used to define surgical margin and to provide a direct assessment of the therapeutic effectiveness. PMID:24310585

  8. Advances in bio-optical imaging for the diagnosis of early oral cancer.

    PubMed

    Olivo, Malini; Bhuvaneswari, Ramaswamy; Keogh, Ivan

    2011-01-01

    Oral cancer is among the most common malignancies worldwide, therefore early detection and treatment is imperative. The 5-year survival rate has remained at a dismal 50% for the past several decades. The main reason for the poor survival rate is the fact that most of the oral cancers, despite the general accessibility of the oral cavity, are not diagnosed until the advanced stage. Early detection of the oral tumors and its precursor lesions may be the most effective means to improve clinical outcome and cure most patients. One of the emerging technologies is the use of non-invasive in vivo tissue imaging to capture the molecular changes at high-resolution to improve the detection capability of early stage disease. This review will discuss the use of optical probes and highlight the role of optical imaging such as autofluorescence, fluorescence diagnosis (FD), laser confocal endomicroscopy (LCE), surface enhanced Raman spectroscopy (SERS), optical coherence tomography (OCT) and confocal reflectance microscopy (CRM) in early oral cancer detection. FD is a promising method to differentiate cancerous lesions from benign, thus helping in the determination of adequate resolution of surgical resection margin. LCE offers in vivo cellular imaging of tissue structures from surface to subsurface layers and has demonstrated the potential to be used as a minimally invasive optical biopsy technique for early diagnosis of oral cancer lesions. SERS was able to differentiate between normal and oral cancer patients based on the spectra acquired from saliva of patients. OCT has been used to visualize the detailed histological features of the oral lesions with an imaging depth down to 2-3 mm. CRM is an optical tool to noninvasively image tissue with near histological resolution. These comprehensive diagnostic modalities can also be used to define surgical margin and to provide a direct assessment of the therapeutic effectiveness. PMID:24310585

  9. Applications of Gas Imaging Micro-Well Detectors to an Advanced Compton Telescope

    NASA Technical Reports Server (NTRS)

    Bloser, P. F.; Hunter, S. D.; Ryan, J. M.; McConnell, M. L.; Miller, R. S.; Jackson, T. N.; Bai, B.; Jung, S.

    2003-01-01

    We present a concept for an Advanced Compton Telescope (ACT) based on the use of pixelized gas micro-well detectors to form a three-dimensional electron track imager. A micro-well detector consists of an array of individual micro-patterned proportional counters opposite a planar drift electrode. When combined with thin film transistor array readouts, large gas volumes may be imaged with very good spatial and energy resolution at reasonable cost. The third dimension is determined by timing the drift of the ionization electrons. The primary advantage of this approach is the excellent tracking of the Compton recoil electron that is possible in a gas volume. Such good electron tracking allows us to reduce the point spread function of a single incident photon dramatically, greatly improving the imaging capability and sensitivity. The polarization sensitivity, which relies on events with large Compton scattering angles, is particularly enhanced. We describe a possible ACT implementation of this technique, in which the gas tracking volume is surrounded by a CsI calorimeter, and present our plans to build and test a small prototype over the next three years.

  10. Assessment of geometric errors of Advanced Himawari-8 Imager (AHI) over one year operation

    NASA Astrophysics Data System (ADS)

    Takeuchi, Wataru

    2016-06-01

    This paper presents an approach to check a geometric performance of Advanced Himawari-8 imager (AHI) and demonstrate and evaluate a new approach to ensure more geometric accurately focusing on visible imagery in 500 meters. A series of processing is supplemented by ground control points of shore lines, land mark locations and digital elevation model. Firstly, a template matching technique is conducted to find a best matching point by simply moving the center of AHI sub-image over each point in a reference image of shore lines and calculating the sum of products between the coefficients and the corresponding neighbourhood pixels in the area spanned by the filter mask. Secondly, ortho-rectification processing is carried out to compensate for the geodetical distortions with respect to the acquisition condition including viewing geometry and so on. As a result, an average of root mean square sum of residual errors with system correction and that of precise geometric correction are shown. Overall geometric accuracy is about 1 to 1.5 pixels from 2015 March to July and it also gradually decreased down to 0.2 to 0.8 from 2015 September to 2016 February. AHI is officially open to public for operational use as of July 1, 2015 and after that operation date geometric errors are reasonably satisfied within one pixels of errors.

  11. Advanced camera image data acquisition system for Pi-of-the-Sky

    NASA Astrophysics Data System (ADS)

    Kwiatkowski, Maciej; Kasprowicz, Grzegorz; Pozniak, Krzysztof; Romaniuk, Ryszard; Wrochna, Grzegorz

    2008-11-01

    The paper describes a new generation of high performance, remote control, CCD cameras designed for astronomical applications. A completely new camera PCB was designed, manufactured, tested and commissioned. The CCD chip was positioned in a different way than previously resulting in better performance of the astronomical video data acquisition system. The camera was built using a low-noise, 4Mpixel CCD circuit by STA. The electronic circuit of the camera is highly parameterized and reconfigurable, as well as modular in comparison with the solution of first generation, due to application of open software solutions and FPGA circuit, Altera Cyclone EP1C6. New algorithms were implemented into the FPGA chip. There were used the following advanced electronic circuit in the camera system: microcontroller CY7C68013a (core 8051) by Cypress, image processor AD9826 by Analog Devices, GigEth interface RTL8169s by Realtec, memory SDRAM AT45DB642 by Atmel, CPU typr microprocessor ARM926EJ-S AT91SAM9260 by ARM and Atmel. Software solutions for the camera and its remote control, as well as image data acquisition are based only on the open source platform. There were used the following image interfaces ISI and API V4L2, data bus AMBA, AHB, INDI protocol. The camera will be replicated in 20 pieces and is designed for continuous on-line, wide angle observations of the sky in the research program Pi-of-the-Sky.

  12. Wild-Type Transthyretin Cardiac Amyloidosis: Novel Insights From Advanced Imaging.

    PubMed

    Narotsky, David L; Castano, Adam; Weinsaft, Jonathan W; Bokhari, Sabahat; Maurer, Mathew S

    2016-09-01

    Amyloidosis is caused by extracellular deposition of abnormal protein fibrils, resulting in destruction of tissue architecture and impairment of organ function. The most common forms of systemic amyloidosis are light-chain and transthyretin-related (ATTR). ATTR can result from an autosomal dominant hereditary transmission of mutated genes in the transthyretin or from a wild-type form of disease (ATTRwt), previously known as senile cardiac amyloidosis. With the aging of the worldwide population, ATTRwt will emerge as the most common type of cardiac amyloidosis that clinicians encounter. Diagnosis of systemic amyloidosis is often delayed, either because of the false assumption that it is a rare disease, or because of misdiagnosis as a result of mistaking it with other conditions. Clinicians must integrate clinical clues from history, physical examination, and common diagnostic tests to raise suspicion for ATTRwt. The historical gold standard for diagnosis of cardiac amyloid is endomyocardial biopsy analysis with pathological distinction of precursor protein type, but this method often results in delayed diagnosis because of the limited availability of expertise to perform and interpret the endomyocardial biopsy specimen. Emerging noninvasive imaging modalities provide easier, accurate screening for ATTRwt. These modalities include advanced echocardiography, using strain imaging and the myocardial contraction fraction; nuclear scintigraphy, which can differentiate between ATTR and light-chain cardiac amyloid; and cardiac magnetic resonance imaging, using extracellular volume measurement, late gadolinium enhancement, and distinct T1 mapping. These novel approaches reveal insights into the prevalence, clinical course, morphological effects, and prognosis of ATTRwt. PMID:27568874

  13. Advanced infrared sounder subpixel cloud detection with imagers and its impact on radiance assimilation in NWP

    NASA Astrophysics Data System (ADS)

    Wang, Pei; Li, Jun; Li, Jinlong; Li, Zhenglong; Schmit, Timothy J.; Bai, Wenguang

    2014-03-01

    Accurate cloud detection is very important for infrared (IR) radiance assimilation; improved cloud detection could reduce cloud contamination and hence improve the assimilation. Although operational numerical weather prediction (NWP) centers are using IR sounder radiance data for cloud detection, collocated high spatial resolution imager data could help sounder subpixel cloud detection and characterization. IR sounder radiances with improved cloud detection using Atmospheric Infrared Sounder (AIRS)/Moderate Resolution Imaging Spectroradiometer (MODIS) were assimilated for Hurricane Sandy (2012). Forecast experiments were run with Weather Research and Forecasting (WRF) as the forecast model and the Three-Dimensional Variational Assimilation (3DVAR)-based Gridpoint Statistical Interpolation (GSI) as the analysis system. Results indicate that forecasts of both hurricane track and intensity are substantially improved when the collocated high spatial resolution MODIS cloud mask is used for AIRS subpixel cloud detection for assimilating radiances. This methodology can be applied to process Crosstrack Infrared Sounder (CRIS)/Visible Infrared Imaging Radiometer Suite (VIIRS) onboard Suomi-NPOESS Preparatory Project (NPP)/Joint Polar Satellite System (JPSS) and Infrared Atmospheric Sounding Interferometer (IASI)/Advanced Very High Resolution Radiometer (AVHRR) onboard the Metop series for improved radiance assimilation in NWP.

  14. Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques.

    PubMed

    Wang, C; Schroeder, F A; Hooker, J M

    2014-04-01

    Abnormal gene regulation as a consequence of flawed epigenetic mechanisms may be central to the initiation and persistence of many human diseases. However, the association of epigenetic dysfunction with disease and the development of therapeutic agents for treatment are slow. Developing new methodologies used to visualize chromatin-modifying enzymes and their function in the human brain would be valuable for the diagnosis of brain disorders and drug discovery. We provide an overview of current invasive and noninvasive techniques for measuring expression and functions of chromatin-modifying enzymes in the brain, emphasizing tools applicable to histone deacetylase (HDAC) enzymes as a leading example. The majority of current techniques are invasive and difficult to translate to what is happening within a human brain in vivo. However, recent progress in molecular imaging provides new, noninvasive ways to visualize epigenetics in the human brain. Neuroimaging tool development presents a unique set of challenges in order to identify and validate CNS radiotracers for HDACs and other histone-modifying enzymes. We summarize advances in the effort to image HDACs and HDAC inhibitory effects in the brain using positron emission tomography (PET) and highlight generalizable techniques that can be adapted to investigate other specific components of epigenetic machinery. Translational tools like neuroimaging by PET and magnetic resonance imaging provide the best way to link our current understanding of epigenetic changes with in vivo function in normal and diseased brains. These tools will be a critical addition to ex vivo methods to evaluate - and intervene - in CNS dysfunction.

  15. Biomarkers in bile-complementing advanced endoscopic imaging in the diagnosis of indeterminate biliary strictures

    PubMed Central

    Lourdusamy, Vennisvasanth; Tharian, Benjamin; Navaneethan, Udayakumar

    2015-01-01

    Biliary strictures present a diagnostic challenge and a conundrum, particularly when an initial work up including abdominal imaging and endoscopic retrograde cholangiopancreatography based sampling are non-diagnostic. Advances in endoscopic imaging have helped us diagnose these strictures better. However, even with modern technology, some strictures remain a diagnostic challenge. The proximity of bile fluid to the bile duct epithelia makes it an attractive option to investigate for bio-markers, which might be representative of the functions/abnormal changes taking place in the biliary system. A number of biomarkers in bile have been discovered recently in approaching biliary strictures with their potential future diagnostic utility, further supported by the immunohistochemical analysis of the resected tissue specimens. Novel biliary biomarkers especially carcinoembryonic cell adhesion molecule 6 and neutrophil gelatinase-associated lipocalin seem promising in differentiating malignant from benign biliary strictures. Recent developments in lipidomic profiling of bile are also very promising. Biliary biomarkers appear to complement endoscopic imaging in diagnosing malignant etiologies of biliary stricture. Future studies addressing these biomarkers need to be incorporated to the current endoscopic techniques to determine the best approach in determining the etiology of biliary strictures. PMID:25901209

  16. Body image in Brazil: recent advances in the state of knowledge and methodological issues

    PubMed Central

    Laus, Maria Fernanda; Kakeshita, Idalina Shiraishi; Costa, Telma Maria Braga; Ferreira, Maria Elisa Caputo; Fortes, Leonardo de Sousa; Almeida, Sebastião Sousa

    2014-01-01

    OBJECTIVE To analyze Brazilian literature on body image and the theoretical and methodological advances that have been made. METHODS A detailed review was undertaken of the Brazilian literature on body image, selecting published articles, dissertations and theses from the SciELO, SCOPUS, LILACS and PubMed databases and the CAPES thesis database. Google Scholar was also used. There was no start date for the search, which used the following search terms: “body image” AND “Brazil” AND “scale(s)”; “body image” AND “Brazil” AND “questionnaire(s)”; “body image” AND “Brazil” AND “instrument(s)”; “body image” limited to Brazil and “body image”. RESULTS The majority of measures available were intended to be used in college students, with half of them evaluating satisfaction/dissatisfaction with the body. Females and adolescents of both sexes were the most studied population. There has been a significant increase in the number of available instruments. Nevertheless, numerous published studies have used non-validated instruments, with much confusion in the use of the appropriate terms (e.g., perception, dissatisfaction, distortion). CONCLUSIONS Much more is needed to understand body image within the Brazilian population, especially in terms of evaluating different age groups and diversifying the components/dimensions assessed. However, interest in this theme is increasing, and important steps have been taken in a short space of time. PMID:24897056

  17. Recent advances in rapid and non-destructive assessment of meat quality using hyperspectral imaging

    NASA Astrophysics Data System (ADS)

    Tao, Feifei; Ngadi, Michael

    2016-05-01

    Meat is an important food item in human diet. Its production and consumption has greatly increased in the last decades with the development of economies and improvement of peoples' living standards. However, most of the traditional methods for evaluation of meat quality are time-consuming, laborious, inconsistent and destructive to samples, which make them not appropriate for a fast-paced production and processing environment. Development of innovative and non-destructive optical sensing techniques to facilitate simple, fast, and accurate evaluation of quality are attracting increasing attention in the food industry. Hyperspectral imaging is one of the promising techniques. It integrates the combined merits of imaging and spectroscopic techniques. This paper provides a comprehensive review on recent advances in evaluation of the important quality attributes of meat including color, marbling, tenderness, pH, water holding capacity, and also chemical composition attributes such as moisture content, protein content and fat content in pork, beef and lamb. In addition, the future potential applications and trends of hyperspectral imaging are also discussed in this paper.

  18. A statistically based flow for image segmentation.

    PubMed

    Pichon, Eric; Tannenbaum, Allen; Kikinis, Ron

    2004-09-01

    In this paper we present a new algorithm for 3D medical image segmentation. The algorithm is versatile, fast, relatively simple to implement, and semi-automatic. It is based on minimizing a global energy defined from a learned non-parametric estimation of the statistics of the region to be segmented. Implementation details are discussed and source code is freely available as part of the 3D Slicer project. In addition, a new unified set of validation metrics is proposed. Results on artificial and real MRI images show that the algorithm performs well on large brain structures both in terms of accuracy and robustness to noise. PMID:15450221

  19. Reverse-Contrast Imaging and Targeted Radiation Therapy of Advanced Pancreatic Cancer Models

    SciTech Connect

    Thorek, Daniel L.J.; Kramer, Robin M.; Chen, Qing; Jeong, Jeho; Lupu, Mihaela E.; Lee, Alycia M.; Moynahan, Mary E.; Lowery, Maeve; Ulmert, David; Zanzonico, Pat; Deasy, Joseph O.; Humm, John L.; Russell, James

    2015-10-01

    Purpose: To evaluate the feasibility of delivering experimental radiation therapy to tumors in the mouse pancreas. Imaging and treatment were performed using combined CT (computed tomography)/orthovoltage treatment with a rotating gantry. Methods and Materials: After intraperitoneal administration of radiopaque iodinated contrast, abdominal organ delineation was performed by x-ray CT. With this technique we delineated the pancreas and both orthotopic xenografts and genetically engineered disease. Computed tomographic imaging was validated by comparison with magnetic resonance imaging. Therapeutic radiation was delivered via a 1-cm diameter field. Selective x-ray radiation therapy of the noninvasively defined orthotopic mass was confirmed using γH2AX staining. Mice could tolerate a dose of 15 Gy when the field was centered on the pancreas tail, and treatment was delivered as a continuous 360° arc. This strategy was then used for radiation therapy planning for selective delivery of therapeutic x-ray radiation therapy to orthotopic tumors. Results: Tumor growth delay after 15 Gy was monitored, using CT and ultrasound to determine the tumor volume at various times after treatment. Our strategy enables the use of clinical radiation oncology approaches to treat experimental tumors in the pancreas of small animals for the first time. We demonstrate that delivery of 15 Gy from a rotating gantry minimizes background healthy tissue damage and significantly retards tumor growth. Conclusions: This advance permits evaluation of radiation planning and dosing parameters. Accurate noninvasive longitudinal imaging and monitoring of tumor progression and therapeutic response in preclinical models is now possible and can be expected to more effectively evaluate pancreatic cancer disease and therapeutic response.

  20. Advanced Imaging for Glaucoma Study: Design, Baseline Characteristics, and Inter-Site Comparison

    PubMed Central

    Le, Phuc V.; Zhang, Xinbo; Francis, Brian A.; Varma, Rohit; Greenfield, David S.; Schuman, Joel S.; Loewen, Nils; Huang, David

    2014-01-01

    Purpose To report the baseline characteristics of the participants in the Advanced Imaging for Glaucoma Study. To compare the participating sites for variations among subjects and the performance of imaging instruments. Design Multi-center longitudinal observational cohort study Methods A total of 788 participants (1,329 eyes) were enrolled from three academic referral centers. There were 145 participants (289 eyes) in the normal group, 394 participants (663 eyes) in the glaucoma suspect/preperimetric glaucoma group, and 249 participants (377 eyes) in the perimetric glaucoma group. Participants underwent a full clinical exam, standard automated perimetry, and imaging with time-domain and Fourier-domain optical coherence tomography (OCT), scanning laser polarimetry, and confocal scanning laser ophthalmoscopy. Main Outcome Measures The baseline average, population standard deviation, and repeatability of imaging-derived anatomic variables were reported for each technology and center. Results Compared to the normal participants, glaucoma suspect/preperimetric glaucoma and perimetric glaucoma groups had significantly reduced anatomic measurements. Repeatability of nerve fiber layer thickness was best for Fourier-domain OCT (overall coefficient of variation < 2%), followed by time-domain OCT (coefficient of variation 2-2.9%), scanning laser polarimetry (coefficient of variation 2.6-4.5%), and confocal scanning laser ophthalmoscopy rim area (coefficient of variation 4.2-7.6%). A mixed-effects model showed that the differences between sites was less than 25 percent of the variation within groups and less than the differences between the normal and glaucoma suspect/preperimetric glaucoma group. Conclusions Site-to-site variation was smaller than both the variation within groups and the changes due to glaucoma. Therefore pooling of participants between sites is appropriate. PMID:25447111

  1. Reverse-contrast imaging and targeted radiation therapy of advanced pancreatic cancer models

    PubMed Central

    Thorek, Daniel L.J.; Kramer, Robin M.; Chen, Qing; Jeong, Jeho; Lupu, Mihaela E.; Lee, Alycia M.; Moynahan, Mary E.; Lowery, Maeve; Ulmert, H. David; Zanzonico, Pat; Deasy, Joseph O.; Humm, John L.; Russell, James

    2015-01-01

    Purpose To evaluate the feasibility of delivering experimental radiotherapy to tumors in the mouse pancreas. Imaging and treatment were performed using combined CT (computed tomography)/orthovoltage treatment with a rotating gantry. Methods and Materials After intraperitoneal administration of radiopaque iodinated contrast, abdominal organ delineation was performed by X-ray CT. With this technique we delineated the pancreas, and both orthotopic xenografts and genetically engineered disease. CT imaging was validated by comparison with magnetic resonance (MR) imaging. Therapeutic radiation was delivered via a 1 cm diameter field. Selective X-ray radiation therapy (XRT) of the non-invasively defined orthotopic mass was confirmed using γH2AX staining. Mice could tolerate a dose of 15 Gy when the field was centered on the pancreas tail, and treatment was delivered as a continuous 360-degree arc. This strategy was then used for radiation therapy planning for selective delivery of therapeutic XRT to orthotopic tumors. Results Tumor growth delay after 15 Gy was monitored, using CT and ultrasound to determine the tumor volume at various times post-treatment. Our strategy enables the use of clinical radiation oncology approaches to treat experimental tumors in the pancreas of small animals for the first time. We demonstrate that delivery of 15 Gy from a rotating gantry minimizes background healthy tissue damage and significantly retards tumor growth. Conclusions This advance permits evaluation of radiation planning and dosing parameters. Accurate non-invasive longitudinal imaging and monitoring of tumor progression and therapeutic response in pre-clinical models is now possible, and can be expected to more effectively evaluate pancreatic cancer disease and therapeutic response. PMID:26238952

  2. Advanced Tie Feature Matching for the Registration of Mobile Mapping Imaging Data and Aerial Imagery

    NASA Astrophysics Data System (ADS)

    Jende, P.; Peter, M.; Gerke, M.; Vosselman, G.

    2016-06-01

    Mobile Mapping's ability to acquire high-resolution ground data is opposing unreliable localisation capabilities of satellite-based positioning systems in urban areas. Buildings shape canyons impeding a direct line-of-sight to navigation satellites resulting in a deficiency to accurately estimate the mobile platform's position. Consequently, acquired data products' positioning quality is considerably diminished. This issue has been widely addressed in the literature and research projects. However, a consistent compliance of sub-decimetre accuracy as well as a correction of errors in height remain unsolved. We propose a novel approach to enhance Mobile Mapping (MM) image orientation based on the utilisation of highly accurate orientation parameters derived from aerial imagery. In addition to that, the diminished exterior orientation parameters of the MM platform will be utilised as they enable the application of accurate matching techniques needed to derive reliable tie information. This tie information will then be used within an adjustment solution to correct affected MM data. This paper presents an advanced feature matching procedure as a prerequisite to the aforementioned orientation update. MM data is ortho-projected to gain a higher resemblance to aerial nadir data simplifying the images' geometry for matching. By utilising MM exterior orientation parameters, search windows may be used in conjunction with a selective keypoint detection and template matching. Originating from different sensor systems, however, difficulties arise with respect to changes in illumination, radiometry and a different original perspective. To respond to these challenges for feature detection, the procedure relies on detecting keypoints in only one image. Initial tests indicate a considerable improvement in comparison to classic detector/descriptor approaches in this particular matching scenario. This method leads to a significant reduction of outliers due to the limited availability

  3. Advanced Numerical Imaging Procedure Accounting for Non-Ideal Effects in GPR Scenarios

    NASA Astrophysics Data System (ADS)

    Comite, Davide; Galli, Alessandro; Catapano, Ilaria; Soldovieri, Francesco

    2015-04-01

    The capability to provide fast and reliable imaging of targets and interfaces in non-accessible probed scenarios is a topic of great scientific interest, and many investigations have shown that Ground Penetrating Radar (GPR) can provide an efficient technique to conduct this kind of analysis in various applications of geophysical nature and civil engineering. In these cases, the development of an efficient and accurate imaging procedure is strongly dependent on the capability of accounting for the incident field that activates the scattering phenomenon. In this frame, based on a suitable implementation of an electromagnetic (EM) CAD tool (CST Microwave Studio), it has been possible to accurately and efficiently model the radiation pattern of real antennas in environments typically considered in GPR surveys [1]. A typical scenario of our interest is constituted by targets hidden in a ground medium, described by certain EM parameters and probed by a movable GPR using interfacial antennas [2]. The transmitting and receiving antennas considered here are Vivaldi ones, but a wide variety of other antennas can be modeled and designed, similar to those ones available in commercial GPR systems. Hence, an advanced version of a well-known microwave tomography approach (MTA) [3] has been implemented, both in the canonical 2D scalar case and in the more realistic 3D vectorial one. Such an approach is able to account for the real distribution of the radiated and scattered EM fields. Comparisons of results obtained by means of a 'conventional' implementation of the MTA, where the antennas are modeled as ideal line sources, and by means of our 'advanced' approach, which instead takes into account the radiation features of the chosen antenna type, have been carried out and discussed. Since the antenna radiation patterns are modified by the probed environment, whose EM features and the possible stratified structure usually are not exactly known, the imaging capabilities of the MTA

  4. Advanced Imaging and Tissue Engineering of the Human Limbal Epithelial Stem Cell Niche

    PubMed Central

    Massie, Isobel; Dziasko, Marc; Kureshi, Alvena; Levis, Hannah J.; Morgan, Louise; Neale, Michael; Sheth, Radhika; Tovell, Victoria E.; Vernon, Amanda J.; Funderburgh, James L.; Daniels, Julie T.

    2015-01-01

    The limbal epithelial stem cell niche provides a unique, physically protective environment in which limbal epithelial stem cells reside in close proximity with accessory cell types and their secreted factors. The use of advanced imaging techniques is described to visualize the niche in three dimensions in native human corneal tissue. In addition, a protocol is provided for the isolation and culture of three different cell types, including human limbal epithelial stem cells from the limbal niche of human donor tissue. Finally, the process of incorporating these cells within plastic compressed collagen constructs to form a tissue-engineered corneal limbus is described and how immunohistochemical techniques may be applied to characterize cell phenotype therein. PMID:25388395

  5. Mission science value-cost savings from the Advanced Imaging Communication System (AICS)

    NASA Technical Reports Server (NTRS)

    Rice, R. F.

    1984-01-01

    An Advanced Imaging Communication System (AICS) was proposed in the mid-1970s as an alternative to the Voyager data/communication system architecture. The AICS achieved virtually error free communication with little loss in the downlink data rate by concatenating a powerful Reed-Solomon block code with the Voyager convolutionally coded, Viterbi decoded downlink channel. The clean channel allowed AICS sophisticated adaptive data compression techniques. Both Voyager and the Galileo mission have implemented AICS components, and the concatenated channel itself is heading for international standardization. An analysis that assigns a dollar value/cost savings to AICS mission performance gains is presented. A conservative value or savings of $3 million for Voyager, $4.5 million for Galileo, and as much as $7 to 9.5 million per mission for future projects such as the proposed Mariner Mar 2 series is shown.

  6. Camera Concepts for the Advanced Gamma-Ray Imaging System (AGIS)

    NASA Astrophysics Data System (ADS)

    Nepomuk Otte, Adam

    2009-05-01

    The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Each telescope is equipped with a camera that detects and records the Cherenkov-light flashes from air showers. The camera is comprised of a pixelated focal plane of blue sensitive and fast (nanosecond) photon detectors that detect the photon signal and convert it into an electrical one. The incorporation of trigger electronics and signal digitization into the camera are under study. Given the size of AGIS, the camera must be reliable, robust, and cost effective. We are investigating several directions that include innovative technologies such as Geiger-mode avalanche-photodiodes as a possible detector and switched capacitor arrays for the digitization.

  7. The multispectral advanced volumetric real-time imaging compositor for real-time distributed scene generation

    NASA Astrophysics Data System (ADS)

    Morris, Joseph W.; Ballard, Gary H.; Bunfield, Dennis H.; Peddycoart, Thomas E.; Trimble, Darian E.

    2011-06-01

    AMRDEC has developed the Multi-spectral Advanced Volumetric Real-time Imaging Compositor (MAVRIC) prototype for distributed real-time hardware-in-the-loop (HWIL) scene generation. MAVRIC is a dynamic object-based energy conserved scene compositor that can seamlessly convolve distributed scene elements into temporally aligned physicsbased scenes for enhancing existing AMRDEC scene generation codes. The volumetric compositing process accepts input independent of depth order. This real-time compositor framework is built around AMRDEC's ContinuumCore API which provides the common messaging interface leveraging the Neutral Messaging Language (NML) for local, shared memory, reflective memory, network, and remote direct memory access (RDMA) communications and the Joint Signature Image Generator (JSIG) that provides energy conserved scene component interface at each render node. This structure allows for a highly scalable real-time environment capable of rendering individual objects at high fidelity while being considerate of real-time hardware-in-the-loop concerns, such as latency. As such, this system can be scaled to handle highly complex detailed scenes such as urban environments. This architecture provides the basis for common scene generation as it provides disparate scene elements to be calculated by various phenomenology codes and integrated seamlessly into a unified composited environment. This advanced capability is the gateway to higher fidelity scene generation such as ray-tracing. The high speed interconnects using PCI Express and InfiniBand were examined to support distributed scene generation whereby the scene graph, associated phenomenology, and the scene elements can be dynamically distributed across multiple high performance computing assets to maximize system performance.

  8. Advances in Echocardiographic Imaging in Heart Failure With Reduced and Preserved Ejection Fraction.

    PubMed

    Omar, Alaa Mabrouk Salem; Bansal, Manish; Sengupta, Partho P

    2016-07-01

    Echocardiography, given its safety, easy availability, and the ability to permit a comprehensive assessment of cardiac structure and function, is an indispensable tool in the evaluation and management of patients with heart failure (HF). From initial phenotyping and risk stratification to providing vital data for guiding therapeutic decision-making and monitoring, echocardiography plays a pivotal role in the care of HF patients. The recent advent of multiparametric approaches for myocardial deformation imaging has provided valuable insights in the pathogenesis of HF, elucidating distinct patterns of myocardial dysfunction and events that are associated with progression from subclinical stage to overt HF. At the same time, miniaturization of echocardiography has further expanded clinical application of echocardiography, with the use of pocket cardiac ultrasound as an adjunct to physical examination demonstrated to improve diagnostic accuracy and risk stratification. Furthermore, ongoing advances in the field of big data analytics promise to create an exciting opportunity to operationalize precision medicine as the new approach to healthcare delivery that aims to individualize patient care by integrating data extracted from clinical, laboratory, echocardiographic, and genetic assessments. The present review summarizes the recent advances in the field of echocardiography, with emphasis on their role in HF phenotyping, risk stratification, and optimizing clinical outcomes. PMID:27390337

  9. Recent Advances in Superparamagnetic Iron Oxide Nanoparticles for Cellular Imaging and Targeted Therapy Research

    PubMed Central

    Wang, Yi-Xiang J.; Xuan, Shouhu; Port, Marc; Idee, Jean-Marc

    2013-01-01

    Advances of nanotechnology have led to the development of nanomaterials with both potential diagnostic and therapeutic applications. Among them, superparamagnetic iron oxide (SPIO) nanoparticles have received particular attention. Over the past decade, various SPIOs with unique physicochemical and biological properties have been designed by modifying the particle structure, size and coating. This article reviews the recent advances in preparing SPIOs with novel properties, the way these physicochemical properties of SPIOs influence their interaction with cells, and the development of SPIOs in liver and lymph nodes magnetic resonance imaging (MRI) contrast. Cellular uptake of SPIO can be exploited in a variety of potential clinical applications, including stem cell and inflammation cell tracking and intra-cellular drug delivery to cancerous cells which offers higher intra-cellular concentration. When SPIOs are used as carrier vehicle, additional advantages can be achieved including magnetic targeting and hyperthermia options, as well as monitoring with MRI. Other potential applications of SPIO include magnetofection and gene delivery, targeted retention of labeled stem cells, sentinel lymph nodes mapping, and magnetic force targeting and cell orientation for tissue engineering. PMID:23621536

  10. Advances in Echocardiographic Imaging in Heart Failure With Reduced and Preserved Ejection Fraction.

    PubMed

    Omar, Alaa Mabrouk Salem; Bansal, Manish; Sengupta, Partho P

    2016-07-01

    Echocardiography, given its safety, easy availability, and the ability to permit a comprehensive assessment of cardiac structure and function, is an indispensable tool in the evaluation and management of patients with heart failure (HF). From initial phenotyping and risk stratification to providing vital data for guiding therapeutic decision-making and monitoring, echocardiography plays a pivotal role in the care of HF patients. The recent advent of multiparametric approaches for myocardial deformation imaging has provided valuable insights in the pathogenesis of HF, elucidating distinct patterns of myocardial dysfunction and events that are associated with progression from subclinical stage to overt HF. At the same time, miniaturization of echocardiography has further expanded clinical application of echocardiography, with the use of pocket cardiac ultrasound as an adjunct to physical examination demonstrated to improve diagnostic accuracy and risk stratification. Furthermore, ongoing advances in the field of big data analytics promise to create an exciting opportunity to operationalize precision medicine as the new approach to healthcare delivery that aims to individualize patient care by integrating data extracted from clinical, laboratory, echocardiographic, and genetic assessments. The present review summarizes the recent advances in the field of echocardiography, with emphasis on their role in HF phenotyping, risk stratification, and optimizing clinical outcomes.

  11. Advanced computational sensors technology: testing and evaluation in visible, SWIR, and LWIR imaging

    NASA Astrophysics Data System (ADS)

    Rizk, Charbel G.; Wilson, John P.; Pouliquen, Philippe

    2015-05-01

    The Advanced Computational Sensors Team at the Johns Hopkins University Applied Physics Laboratory and the Johns Hopkins University Department of Electrical and Computer Engineering has been developing advanced readout integrated circuit (ROIC) technology for more than 10 years with a particular focus on the key challenges of dynamic range, sampling rate, system interface and bandwidth, and detector materials or band dependencies. Because the pixel array offers parallel sampling by default, the team successfully demonstrated that adding smarts in the pixel and the chip can increase performance significantly. Each pixel becomes a smart sensor and can operate independently in collecting, processing, and sharing data. In addition, building on the digital circuit revolution, the effective well size can be increased by orders of magnitude within the same pixel pitch over analog designs. This research has yielded an innovative class of a system-on-chip concept: the Flexible Readout and Integration Sensor (FRIS) architecture. All key parameters are programmable and/or can be adjusted dynamically, and this architecture can potentially be sensor and application agnostic. This paper reports on the testing and evaluation of one prototype that can support either detector polarity and includes sample results with visible, short-wavelength infrared (SWIR), and long-wavelength infrared (LWIR) imaging.

  12. The value of clinical electrophysiology in the assessment of the eye and visual system in the era of advanced imaging.

    PubMed

    Whatham, Andrew R; Nguyen, Vincent; Zhu, Yuan; Hennessy, Michael; Kalloniatis, Michael

    2014-03-01

    Electrophysiological techniques allow clinical investigations to include a 'dissection' of the visual system. Using suitable electrophysiological techniques, the 'dissection' allows function to be ascribed to the different photoreceptors (rod and cone photoreceptors), retinal layers, retinal location or the visual pathway up to the visual cortex. Combined with advances in genetics, retinal biochemistry, visual fields and ocular imaging, it is now possible to obtain a better understanding of diseases affecting the retina and visual pathways. This paper reviews core electrophysiological principles that can complement other examination techniques, including advanced ocular imaging, and help the interpretation of other clinical data and thus, refine and guide clinical diagnosis. PMID:23865913

  13. Post Launch Calibration and Testing of the Advanced Baseline Imager on the GOES-R Satellite

    NASA Technical Reports Server (NTRS)

    Lebair, William; Rollins, C.; Kline, John; Todirita, M.; Kronenwetter, J.

    2016-01-01

    The Geostationary Operational Environmental Satellite R (GOES-R) series is the planned next generation of operational weather satellites for the United State's National Oceanic and Atmospheric Administration. The first launch of the GOES-R series is planned for October 2016. The GOES-R series satellites and instruments are being developed by the National Aeronautics and Space Administration (NASA). One of the key instruments on the GOES-R series is the Advance Baseline Imager (ABI). The ABI is a multi-channel, visible through infrared, passive imaging radiometer. The ABI will provide moderate spatial and spectral resolution at high temporal and radiometric resolution to accurately monitor rapidly changing weather. Initial on-orbit calibration and performance characterization is crucial to establishing baseline used to maintain performance throughout mission life. A series of tests has been planned to establish the post launch performance and establish the parameters needed to process the data in the Ground Processing Algorithm. The large number of detectors for each channel required to provide the needed temporal coverage presents unique challenges for accurately calibrating ABI and minimizing striping. This paper discusses the planned tests to be performed on ABI over the six-month Post Launch Test period and the expected performance as it relates to ground tests.

  14. Utilization of optical image data from the Advanced Test Accelerator (ATA)

    SciTech Connect

    Chambers, F.W.; Kallman, J.S.; Slominski, M.E.; Chong, Y.P.; Donnelly, D.; Cornish, J.P.

    1987-01-01

    Extensive use is made of optical diagnostics to obtain information on the 50-MeV, 10-kA, 70-ns pulsed-electron beam produced by the Advanced Test Accelerator (ATA). Light is generated by the beam striking a foil inserted in the beamline or through excitation of the gas when the beamline is filled with air. The emitted light is collected and digitized. Two-dimensional images are recorded by either a gated framing camera or a streak camera. Extraction of relevant beam parameters, such as current density, current, and beam size, requires an understanding of the physics of the light-generation mechanism and an ability to handle and properly exploit a large digital database of image data. We will present a brief overview of the present understanding of the light-generation mechanisms in foil and gas, with emphasis on experimental observations and trends. We will review our data management and analysis techniques and indicate successful approaches for extracting beam parameters.

  15. New dual gas puff imaging system with up-down symmetry on experimental advanced superconducting tokamak

    NASA Astrophysics Data System (ADS)

    Liu, S. C.; Shao, L. M.; Zweben, S. J.; Xu, G. S.; Guo, H. Y.; Cao, B.; Wang, H. Q.; Wang, L.; Yan, N.; Xia, S. B.; Zhang, W.; Chen, R.; Chen, L.; Ding, S. Y.; Xiong, H.; Zhao, Y.; Wan, B. N.; Gong, X. Z.; Gao, X.

    2012-12-01

    Gas puff imaging (GPI) offers a direct and effective diagnostic to measure the edge turbulence structure and velocity in the edge plasma, which closely relates to edge transport and instability in tokamaks. A dual GPI diagnostic system has been installed on the low field side on experimental advanced superconducting tokamak (EAST). The two views are up-down symmetric about the midplane and separated by a toroidal angle of 66.6°. A linear manifold with 16 holes apart by 10 mm is used to form helium gas cloud at the 130×130 mm (radial versus poloidal) objective plane. A fast camera is used to capture the light emission from the image plane with a speed up to 390 804 frames/s with 64×64 pixels and an exposure time of 2.156 μs. The spatial resolution of the system is 2 mm at the objective plane. A total amount of 200 Pa.L helium gas is puffed into the plasma edge for each GPI viewing region for about 250 ms. The new GPI diagnostic has been applied on EAST for the first time during the recent experimental campaign under various plasma conditions, including ohmic, L-mode, and type-I, and type-III ELMy H-modes. Some of these initial experimental results are also presented.

  16. A Combined Method for Segmentation and Registration for an Advanced and Progressive Evaluation of Thermal Images

    PubMed Central

    Barcelos, Emilio Z.; Caminhas, Walmir M.; Ribeiro, Eraldo; Pimenta, Eduardo M.; Palhares, Reinaldo M.

    2014-01-01

    In this paper, a method that combines image analysis techniques, such as segmentation and registration, is proposed for an advanced and progressive evaluation of thermograms. The method is applied for the prevention of muscle injury in high-performance athletes, in collaboration with a Brazilian professional soccer club. The goal is to produce information on spatio-temporal variations of thermograms favoring the investigation of the athletes' conditions along the competition. The proposed method improves on current practice by providing a means for automatically detecting adaptive body-shaped regions of interest, instead of the manual selection of simple shapes. Specifically, our approach combines the optimization features in Otsu's method with a correction factor and post-processing techniques, enhancing thermal-image segmentation when compared to other methods. Additional contributions resulting from the combination of the segmentation and registration steps of our approach are the progressive analyses of thermograms in a unique spatial coordinate system and the accurate extraction of measurements and isotherms. PMID:25414972

  17. Fire service and first responder thermal imaging camera (TIC) advances and standards

    NASA Astrophysics Data System (ADS)

    Konsin, Lawrence S.; Nixdorff, Stuart

    2007-04-01

    Fire Service and First Responder Thermal Imaging Camera (TIC) applications are growing, saving lives and preventing injury and property damage. Firefighters face a wide range of serious hazards. TICs help mitigate the risks by protecting Firefighters and preventing injury, while reducing time spent fighting the fire and resources needed to do so. Most fire safety equipment is covered by performance standards. Fire TICs, however, are not covered by such standards and are also subject to inadequate operational performance and insufficient user training. Meanwhile, advancements in Fire TICs and lower costs are driving product demand. The need for a Fire TIC Standard was spurred in late 2004 through a Government sponsored Workshop where experts from the First Responder community, component manufacturers, firefighter training, and those doing research on TICs discussed strategies, technologies, procedures, best practices and R&D that could improve Fire TICs. The workshop identified pressing image quality, performance metrics, and standards issues. Durability and ruggedness metrics and standard testing methods were also seen as important, as was TIC training and certification of end-users. A progress report on several efforts in these areas and their impact on the IR sensor industry will be given. This paper is a follow up to the SPIE Orlando 2004 paper on Fire TIC usage (entitled Emergency Responders' Critical Infrared) which explored the technological development of this IR industry segment from the viewpoint of the end user, in light of the studies and reports that had established TICs as a mission critical tool for firefighters.

  18. AXIS: an instrument for imaging Compton radiographs using the Advanced Radiography Capability on the NIF.

    PubMed

    Hall, G N; Izumi, N; Tommasini, R; Carpenter, A C; Palmer, N E; Zacharias, R; Felker, B; Holder, J P; Allen, F V; Bell, P M; Bradley, D; Montesanti, R; Landen, O L

    2014-11-01

    Compton radiography is an important diagnostic for Inertial Confinement Fusion (ICF), as it provides a means to measure the density and asymmetries of the DT fuel in an ICF capsule near the time of peak compression. The AXIS instrument (ARC (Advanced Radiography Capability) X-ray Imaging System) is a gated detector in development for the National Ignition Facility (NIF), and will initially be capable of recording two Compton radiographs during a single NIF shot. The principal reason for the development of AXIS is the requirement for significantly improved detection quantum efficiency (DQE) at high x-ray energies. AXIS will be the detector for Compton radiography driven by the ARC laser, which will be used to produce Bremsstrahlung X-ray backlighter sources over the range of 50 keV-200 keV for this purpose. It is expected that AXIS will be capable of recording these high-energy x-rays with a DQE several times greater than other X-ray cameras at NIF, as well as providing a much larger field of view of the imploded capsule. AXIS will therefore provide an image with larger signal-to-noise that will allow the density and distribution of the compressed DT fuel to be measured with significantly greater accuracy as ICF experiments are tuned for ignition. PMID:25430200

  19. Advanced Imaging and Receipt of Guideline Concordant Care in Women with Early Stage Breast Cancer

    PubMed Central

    Buist, Diana S. M.; Gold, Laura S.; Zeliadt, Steven; Hunter Merrill, Rachel; Etzioni, Ruth; Ramsey, Scott D.; Sullivan, Sean D.; Kessler, Larry

    2016-01-01

    Objective. It is unknown whether advanced imaging (AI) is associated with higher quality breast cancer (BC) care. Materials and Methods. Claims and Surveillance Epidemiology and End Results data were linked for women diagnosed with incident stage I-III BC between 2002 and 2008 in western Washington State. We examined receipt of preoperative breast magnetic resonance imaging (MRI) or AI (defined as computed tomography [CT]/positron emission tomography [PET]/PET/CT) versus mammogram and/or ultrasound (M-US) alone and receipt of guideline concordant care (GCC) using multivariable logistic regression. Results. Of 5247 women, 67% received M-US, 23% MRI, 8% CT, and 3% PET/PET-CT. In 2002, 5% received MRI and 5% AI compared to 45% and 12%, respectively, in 2008. 79% received GCC, but GCC declined over time and was associated with younger age, urban residence, less comorbidity, shorter time from diagnosis to surgery, and earlier year of diagnosis. Breast MRI was associated with GCC for lumpectomy plus radiation therapy (RT) (OR 1.55, 95% CI 1.08–2.26, and p = 0.02) and AI was associated with GCC for adjuvant chemotherapy for estrogen-receptor positive (ER+) BC (OR 1.74, 95% CI 1.17–2.59, and p = 0.01). Conclusion. GCC was associated with prior receipt of breast MRI and AI for lumpectomy plus RT and adjuvant chemotherapy for ER+ BC, respectively. PMID:27525122

  20. AXIS: An instrument for imaging Compton radiographs using the Advanced Radiography Capability on the NIF

    SciTech Connect

    Hall, G. N. Izumi, N.; Tommasini, R.; Carpenter, A. C.; Palmer, N. E.; Zacharias, R.; Felker, B.; Holder, J. P.; Allen, F. V.; Bell, P. M.; Bradley, D.; Montesanti, R.; Landen, O. L.

    2014-11-15

    Compton radiography is an important diagnostic for Inertial Confinement Fusion (ICF), as it provides a means to measure the density and asymmetries of the DT fuel in an ICF capsule near the time of peak compression. The AXIS instrument (ARC (Advanced Radiography Capability) X-ray Imaging System) is a gated detector in development for the National Ignition Facility (NIF), and will initially be capable of recording two Compton radiographs during a single NIF shot. The principal reason for the development of AXIS is the requirement for significantly improved detection quantum efficiency (DQE) at high x-ray energies. AXIS will be the detector for Compton radiography driven by the ARC laser, which will be used to produce Bremsstrahlung X-ray backlighter sources over the range of 50 keV–200 keV for this purpose. It is expected that AXIS will be capable of recording these high-energy x-rays with a DQE several times greater than other X-ray cameras at NIF, as well as providing a much larger field of view of the imploded capsule. AXIS will therefore provide an image with larger signal-to-noise that will allow the density and distribution of the compressed DT fuel to be measured with significantly greater accuracy as ICF experiments are tuned for ignition.

  1. System performance advances of 18-mm and 16-mm subminiature image intensifier sensors

    NASA Astrophysics Data System (ADS)

    Thomas, Nils I.

    2000-11-01

    Night vision system design has been centered aroudn the An/AVS-6 and AN/PVS-7 night vision goggle systems for the past 20 years. Goggle performance has improved during this time through increased performance of the image intensifier sensor, primarily the Omni IV sensor from ITT Industries Night Vision. Most of this improvement has been at the optimal light level (1E-3 fc scene illumination). Recent advances in image sensor performance from the filmless Generation (Gen) IV sensors has increased the low light level performance of night vision devices from 0.3 cy/mr to 0.7 cy/mr. In addition, sensor packaging design requirements have forced night vision sensor manufactures to design light weight, small volume sensors. ITT recently has designed such a sensor in a 16-mm format. This sensor if 50% lighter, up to 50% shorter, and has design features that simplify the objective lens design. New night vision goggles have been, and are being, designed which reduce the perceived head-supported weight. This paper presents signal-to-noise ratio, halo, and other film-less sensor data and similar 16-mm subminiature sensor data. The resulting system performance data will be described. Finally, the system design improvements and relationships with the subminiature 16-mm subminiature sensor will be given.

  2. Advances in Surface Plasmon Resonance Imaging enable quantitative measurement of laterally heterogeneous coatings of nanoscale thickness

    NASA Astrophysics Data System (ADS)

    Raegen, Adam; Reiter, Kyle; Clarke, Anthony; Lipkowski, Jacek; Dutcher, John

    2013-03-01

    The Surface Plasmon Resonance (SPR) phenomenon is routinely exploited to qualitatively probe changes to the optical properties of nanoscale coatings on thin metallic surfaces, for use in probes and sensors. Unfortunately, extracting truly quantitative information is usually limited to a select few cases - uniform absorption/desorption of small biomolecules and films, in which a continuous ``slab'' model is a good approximation. We present advancements in the SPR technique that expand the number of cases for which the technique can provide meaningful results. Use of a custom, angle-scanning SPR imaging system, together with a refined data analysis method, allow for quantitative kinetic measurements of laterally heterogeneous systems. We first demonstrate the directionally heterogeneous nature of the SPR phenomenon using a directionally ordered sample, then show how this allows for the calculation of the average coverage of a heterogeneous sample. Finally, the degradation of cellulose microfibrils and bundles of microfibrils due to the action of cellulolytic enzymes will be presented as an excellent example of the capabilities of the SPR imaging system.

  3. Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology

    PubMed Central

    Niendorf, Thoralf; Pohlmann, Andreas; Reimann, Henning M.; Waiczies, Helmar; Peper, Eva; Huelnhagen, Till; Seeliger, Erdmann; Schreiber, Adrian; Kettritz, Ralph; Strobel, Klaus; Ku, Min-Chi; Waiczies, Sonia

    2015-01-01

    Research in pathologies of the brain, heart and kidney have gained immensely from the plethora of studies that have helped shape new methods in magnetic resonance (MR) for characterizing preclinical disease models. Methodical probing into preclinical animal models by MR is invaluable since it allows a careful interpretation and extrapolation of data derived from these models to human disease. In this review we will focus on the applications of cryogenic radiofrequency (RF) coils in small animal MR as a means of boosting image quality (e.g., by supporting MR microscopy) and making data acquisition more efficient (e.g., by reducing measuring time); both being important constituents for thorough investigational studies on animal models of disease. This review attempts to make the (bio)medical imaging, molecular medicine, and pharmaceutical communities aware of this productive ferment and its outstanding significance for anatomical and functional MR in small rodents. The goal is to inspire a more intense interdisciplinary collaboration across the fields to further advance and progress non-invasive MR methods that ultimately support thorough (patho)physiological characterization of animal disease models. In this review, current and potential future applications for the RF coil technology in cardiovascular, neurovascular, and renal disease will be discussed. PMID:26617515

  4. AXIS: an instrument for imaging Compton radiographs using the Advanced Radiography Capability on the NIF.

    PubMed

    Hall, G N; Izumi, N; Tommasini, R; Carpenter, A C; Palmer, N E; Zacharias, R; Felker, B; Holder, J P; Allen, F V; Bell, P M; Bradley, D; Montesanti, R; Landen, O L

    2014-11-01

    Compton radiography is an important diagnostic for Inertial Confinement Fusion (ICF), as it provides a means to measure the density and asymmetries of the DT fuel in an ICF capsule near the time of peak compression. The AXIS instrument (ARC (Advanced Radiography Capability) X-ray Imaging System) is a gated detector in development for the National Ignition Facility (NIF), and will initially be capable of recording two Compton radiographs during a single NIF shot. The principal reason for the development of AXIS is the requirement for significantly improved detection quantum efficiency (DQE) at high x-ray energies. AXIS will be the detector for Compton radiography driven by the ARC laser, which will be used to produce Bremsstrahlung X-ray backlighter sources over the range of 50 keV-200 keV for this purpose. It is expected that AXIS will be capable of recording these high-energy x-rays with a DQE several times greater than other X-ray cameras at NIF, as well as providing a much larger field of view of the imploded capsule. AXIS will therefore provide an image with larger signal-to-noise that will allow the density and distribution of the compressed DT fuel to be measured with significantly greater accuracy as ICF experiments are tuned for ignition.

  5. Post launch calibration and testing of the Advanced Baseline Imager on the GOES-R satellite

    NASA Astrophysics Data System (ADS)

    Lebair, William; Rollins, C.; Kline, John; Todirita, M.; Kronenwetter, J.

    2016-05-01

    The Geostationary Operational Environmental Satellite R (GOES-R) series is the planned next generation of operational weather satellites for the United State's National Oceanic and Atmospheric Administration. The first launch of the GOES-R series is planned for October 2016. The GOES-R series satellites and instruments are being developed by the National Aeronautics and Space Administration (NASA). One of the key instruments on the GOES-R series is the Advance Baseline Imager (ABI). The ABI is a multi-channel, visible through infrared, passive imaging radiometer. The ABI will provide moderate spatial and spectral resolution at high temporal and radiometric resolution to accurately monitor rapidly changing weather. Initial on-orbit calibration and performance characterization is crucial to establishing baseline used to maintain performance throughout mission life. A series of tests has been planned to establish the post launch performance and establish the parameters needed to process the data in the Ground Processing Algorithm. The large number of detectors for each channel required to provide the needed temporal coverage presents unique challenges for accurately calibrating ABI and minimizing striping. This paper discusses the planned tests to be performed on ABI over the six-month Post Launch Test period and the expected performance as it relates to ground tests.

  6. Radiometric calibration stability of the EO-1 advanced land imager: 5 years on-orbit

    USGS Publications Warehouse

    Markham, B.L.; Ong, L.; Barsi, J.A.; Mendenhall, J.A.; Lencioni, D.E.; Helder, D.L.; Hollaren, D.M.; Morfitt, R.

    2006-01-01

    The Advanced Land Imager (ALI) was developed as a prototype sensor for follow on missions to Landsat-7. It was launched in November 2000 on the Earth Observing One (EO-1) satellite as a nominal one-year technology demonstration mission. As of this writing, the sensor has continued to operate in excess of 5 years. Six of the ALl's nine multi-spectral (MS) bands and the panchromatic band have similar spectral coverage as those on the Landsat-7 ETM+. In addition to on-board lamps, which have been significantly more stable than the lamps on ETM+, the ALI has a solar diffuser and has imaged the moon monthly since launch. This combined calibration dataset allows understanding of the radiometric stability of the ALI system, its calibrators and some differentiation of the sources of the changes with time. The solar dataset is limited as the mechanism controlling the aperture to the solar diffuser failed approximately 18 months after launch. Results over 5 years indicate that: the shortest wavelength band (443 nm) has degraded in response about 2%; the 482 nm and 565 nm bands decreased in response about 1%; the 660 nm, 790 nm and 868 nm bands each degraded about 5%; the 1250 nm and 1650 nm bands did not change significantly and the 2215 nm band increased in response about 2%.

  7. Radiometric calibration stability of the EO-1 Advanced Land Imager: 5 years on-orbit

    NASA Astrophysics Data System (ADS)

    Markham, Brian L.; Ong, Lawrence; Barsi, Julia A.; Mendenhall, Jeffrey A.; Lencioni, Donald E.; Helder, Dennis L.; Hollaren, Douglas M.; Morfitt, Ron

    2006-09-01

    The Advanced Land Imager (ALI) was developed as a prototype sensor for follow on missions to Landsat-7. It was launched in November 2000 on the Earth Observing One (EO-1) satellite as a nominal one-year technology demonstration mission. As of this writing, the sensor has continued to operate in excess of 5 years. Six of the ALI's nine multi-spectral (MS) bands and the panchromatic band have similar spectral coverage as those on the Landsat-7 ETM+. In addition to on-board lamps, which have been significantly more stable than the lamps on ETM+, the ALI has a solar diffuser and has imaged the moon monthly since launch. This combined calibration dataset allows understanding of the radiometric stability of the ALI system, its calibrators and some differentiation of the sources of the changes with time. The solar dataset is limited as the mechanism controlling the aperture to the solar diffuser failed approximately 18 months after launch. Results over 5 years indicate that: the shortest wavelength band (443 nm) has degraded in response about 2%; the 482 nm and 565 nm bands decreased in response about 1%; the 660 nm, 790 nm and 868 nm bands each degraded about 5%; the 1250 nm and 1650 nm bands did not change significantly and the 2215 nm band increased in response about 2%.

  8. Advanced Imaging and Receipt of Guideline Concordant Care in Women with Early Stage Breast Cancer.

    PubMed

    Loggers, Elizabeth Trice; Buist, Diana S M; Gold, Laura S; Zeliadt, Steven; Hunter Merrill, Rachel; Etzioni, Ruth; Ramsey, Scott D; Sullivan, Sean D; Kessler, Larry

    2016-01-01

    Objective. It is unknown whether advanced imaging (AI) is associated with higher quality breast cancer (BC) care. Materials and Methods. Claims and Surveillance Epidemiology and End Results data were linked for women diagnosed with incident stage I-III BC between 2002 and 2008 in western Washington State. We examined receipt of preoperative breast magnetic resonance imaging (MRI) or AI (defined as computed tomography [CT]/positron emission tomography [PET]/PET/CT) versus mammogram and/or ultrasound (M-US) alone and receipt of guideline concordant care (GCC) using multivariable logistic regression. Results. Of 5247 women, 67% received M-US, 23% MRI, 8% CT, and 3% PET/PET-CT. In 2002, 5% received MRI and 5% AI compared to 45% and 12%, respectively, in 2008. 79% received GCC, but GCC declined over time and was associated with younger age, urban residence, less comorbidity, shorter time from diagnosis to surgery, and earlier year of diagnosis. Breast MRI was associated with GCC for lumpectomy plus radiation therapy (RT) (OR 1.55, 95% CI 1.08-2.26, and p = 0.02) and AI was associated with GCC for adjuvant chemotherapy for estrogen-receptor positive (ER+) BC (OR 1.74, 95% CI 1.17-2.59, and p = 0.01). Conclusion. GCC was associated with prior receipt of breast MRI and AI for lumpectomy plus RT and adjuvant chemotherapy for ER+ BC, respectively. PMID:27525122

  9. Advancing Cardiovascular, Neurovascular, and Renal Magnetic Resonance Imaging in Small Rodents Using Cryogenic Radiofrequency Coil Technology.

    PubMed

    Niendorf, Thoralf; Pohlmann, Andreas; Reimann, Henning M; Waiczies, Helmar; Peper, Eva; Huelnhagen, Till; Seeliger, Erdmann; Schreiber, Adrian; Kettritz, Ralph; Strobel, Klaus; Ku, Min-Chi; Waiczies, Sonia

    2015-01-01

    Research in pathologies of the brain, heart and kidney have gained immensely from the plethora of studies that have helped shape new methods in magnetic resonance (MR) for characterizing preclinical disease models. Methodical probing into preclinical animal models by MR is invaluable since it allows a careful interpretation and extrapolation of data derived from these models to human disease. In this review we will focus on the applications of cryogenic radiofrequency (RF) coils in small animal MR as a means of boosting image quality (e.g., by supporting MR microscopy) and making data acquisition more efficient (e.g., by reducing measuring time); both being important constituents for thorough investigational studies on animal models of disease. This review attempts to make the (bio)medical imaging, molecular medicine, and pharmaceutical communities aware of this productive ferment and its outstanding significance for anatomical and functional MR in small rodents. The goal is to inspire a more intense interdisciplinary collaboration across the fields to further advance and progress non-invasive MR methods that ultimately support thorough (patho)physiological characterization of animal disease models. In this review, current and potential future applications for the RF coil technology in cardiovascular, neurovascular, and renal disease will be discussed.

  10. ABrIL - Advanced Brain Imaging Lab : a cloud based computation environment for cooperative neuroimaging projects.

    PubMed

    Neves Tafula, Sérgio M; Moreira da Silva, Nádia; Rozanski, Verena E; Silva Cunha, João Paulo

    2014-01-01

    Neuroscience is an increasingly multidisciplinary and highly cooperative field where neuroimaging plays an important role. Neuroimaging rapid evolution is demanding for a growing number of computing resources and skills that need to be put in place at every lab. Typically each group tries to setup their own servers and workstations to support their neuroimaging needs, having to learn from Operating System management to specific neuroscience software tools details before any results can be obtained from each setup. This setup and learning process is replicated in every lab, even if a strong collaboration among several groups is going on. In this paper we present a new cloud service model - Brain Imaging Application as a Service (BiAaaS) - and one of its implementation - Advanced Brain Imaging Lab (ABrIL) - in the form of an ubiquitous virtual desktop remote infrastructure that offers a set of neuroimaging computational services in an interactive neuroscientist-friendly graphical user interface (GUI). This remote desktop has been used for several multi-institution cooperative projects with different neuroscience objectives that already achieved important results, such as the contribution to a high impact paper published in the January issue of the Neuroimage journal. The ABrIL system has shown its applicability in several neuroscience projects with a relatively low-cost, promoting truly collaborative actions and speeding up project results and their clinical applicability.

  11. Advanced prism-grating-prism imaging spectrograph in online industrial applications

    NASA Astrophysics Data System (ADS)

    Vaarala, Tapio; Aikio, Mauri; Keraenen, Heimo

    1997-08-01

    Imaging spectrographs have traditionally been utilized in aerial and remote sensing applications. A novel, compact and inexpensive imaging spectrograph developed by VTT Electronics is now available. It contains a multichannel fiber optic sensor head, a dispersive prism-grating-prism (PGP) component and digital CCD matrix camera capable of area integration. In rolled steel manufacturing, a protective oil film is applied on steel to resist corrosion while in transport and storage. The main problems in the oiling machine are film thickness control and jet failures. In this application, the spectrum of fluorescence of an oil film was measured simultaneously with parallel fibers. A relatively simple calibration and analysis procedure was used to calculate the oil film thickness. On-line color control for color reproduction is essential in both consumer and industrial products. The instrument was tested and analyzed for measuring differences in color by multivariate analysis of the spectra and by color space coordinate estimation. In general, a continuous spectrum is not absolute requirement. In these two examples, filter-based measurement would probably cost less thana PGP spectrograph solution. On the other hand, by measuring the spectrum and using an advanced signal processing algorithm one production version will cover all installations in both applications. In practice, only the fiber sensor mechanics need to be modified.

  12. Carbon-Based Nanostructures as Advanced Contrast Agents for Magnetic Resonance Imaging

    NASA Astrophysics Data System (ADS)

    Ananta Narayanan, Jeyarama S.

    2011-12-01

    Superparamagnetic carbon-based nanostructures are presented as contrast agents (CAs) for advanced imaging applications such as cellular and molecular imaging using magnetic resonance imaging (MRI). Gadolinium-loaded, ultra-short single-walled carbon nanotubes (gadonanotubes; GNTs) are shown to have extremely high r1 relaxivities (contrast enhancement efficacy), especially at low-magnetic field strengths. The inherent lipophilicity of GNTs provides them the ability to image cells at low magnetic field strength. A carboxylated dextran-coated GNT (GadoDex) has been synthesized and proposed as a new biocompatible high-performance MRI CA. The r1 relaxivity is ca. 20 times greater than for other paramagnetic Gd-based CAs. This enhanced relaxivity for GadoDex is due to the synergistic effects of an increased molecular tumbling time (tauR) and a faster proton exchange rate (taum). GNTs also exhibit very large transverse relaxivities (r2) at high magnetic fields (≥ 3 T). The dependence of the transverse relaxation rates (especially R2*) of labeled cells on GNT concentration offers the possibility to quantify cell population in vivo using R2* mapping. The cell-labeling efficiency and high transverse relaxivities of GNTs has enabled the first non-iron oxide-based single-cell imaging using MRI. The residual metal catalyst particles of SWNT materials also have transverse relaxation properties. All of the SWNT materials exhibit superior transverse relaxation properties. However, purified SWNTs and US-tubes with less residual metal content exhibit better transverse relaxivities (r2), demonstrating the importance of the SWNT structure for enhanced MRI CA performance. A strategy to improve the r1 relaxivity of Gd-CAs by geometrically confining them within porous silicon particles (SiMPs) has been investigated. The enhancement in relaxivity is attributed to the slow diffusion of water molecules through the pores and the increase in the molecular tumbling time of the nanoconstruct

  13. The GOES-R Advanced Baseline Imager: polarization sensitivity and potential impacts

    NASA Astrophysics Data System (ADS)

    Pearlman, Aaron J.; Cao, Changyong; Wu, Xiangqian

    2015-09-01

    In contrast to the National Oceanic and Atmospheric Administration's (NOAA's) current geostationary imagers for operational weather forecasting, the next generation imager, the Advanced Baseline Imager (ABI) aboard the Geostationary Operational Environmental Satellite R-Series (GOES-R), will have six reflective solar bands - five more than currently available. These bands will be used for applications such as aerosol retrievals, which are influenced by polarization effects. These effects are determined by two factors: instrument polarization sensitivity and the polarization states of the observations. The former is measured as part of the pre-launch testing program performed by the instrument vendor. We analyzed the results of the pre-launch polarization sensitivity measurements of the 0.47 μm and 0.64 μm channels and used them in conjunction with simulated scene polarization states to estimate potential on-orbit radiometric impacts. The pre-launch test setups involved illuminating the ABI with an integrating sphere through either one or two polarizers. The measurement with one (rotating) polarizer yields the degree of linear polarization of ABI, and the measurements using two polarizers (one rotating and one fixed) characterized the non-ideal properties of the polarizer. To estimate the radiometric performance impacts from the instrument polarization sensitivity, we simulated polarized scenes using a radiative transfer code and accounted for the instrument polarization sensitivity over its field of regard. The results show the variation in the polarization impacts over the day and by regions of the full disk can reach up to 3.2% for the 0.47μm channel and 4.8% for the 0.64μm channel. Geostationary orbiters like the ABI give the unique opportunity to show these impacts throughout the day compared to low earth orbiters, which are more limited to certain times of day. This work may enhance the ability to diagnose anomalies on-orbit.

  14. Strong-Lensing Analysis of A1689 from Deep Advanced Camera Images

    NASA Astrophysics Data System (ADS)

    Broadhurst, Tom; Benítez, Narciso; Coe, Dan; Sharon, Keren; Zekser, Kerry; White, Rick; Ford, Holland; Bouwens, Rychard; Blakeslee, John; Clampin, Marc; Cross, Nick; Franx, Marijn; Frye, Brenda; Hartig, George; Illingworth, Garth; Infante, Leopoldo; Menanteau, Felipe; Meurer, Gerhardt; Postman, Marc; Ardila, D. R.; Bartko, F.; Brown, R. A.; Burrows, C. J.; Cheng, E. S.; Feldman, P. D.; Golimowski, D. A.; Goto, T.; Gronwall, C.; Herranz, D.; Holden, B.; Homeier, N.; Krist, J. E.; Lesser, M. P.; Martel, A. R.; Miley, G. K.; Rosati, P.; Sirianni, M.; Sparks, W. B.; Steindling, S.; Tran, H. D.; Tsvetanov, Z. I.; Zheng, W.

    2005-03-01

    We analyze deep multicolor Advanced Camera images of the largest known gravitational lens, A1689. Radial and tangential arcs delineate the critical curves in unprecedented detail, and many small counterimages are found near the center of mass. We construct a flexible light deflection field to predict the appearance and positions of counterimages. The model is refined as new counterimages are identified and incorporated to improve the model, yielding a total of 106 images of 30 multiply lensed background galaxies, spanning a wide redshift range, 1.0images are reproduced well by our best-fitting lens model.

  15. Image slicing with a twist: spatial and spectral Nyquist sampling without anamorphic optics

    NASA Astrophysics Data System (ADS)

    Tecza, Matthias

    2014-07-01

    Integral field spectrographs have become mainstream instruments at modern telescopes because of their efficient way of collecting data-cubes. Image slicer based integral field spectrographs achieve the highest fill-factor on the detector, but due to the need to Nyquist-sample the spectra, their spatial sampling on the sky is rectangular. Using anamorphic pre-optics before the image slicer overcomes this effect further maximising the fill-factor, but introduces optical aberrations, throughput losses, and additional alignment and calibration requirements, compromising overall instrument performance. In this paper I present a concept for an image-slicer that achieves both spatial and spectral Nyquist-sampling without anamorphic pre-optics. Rotating each slitlet by 45° with respect to the dispersion direction, and arranging them into a saw-tooth pseudo-slit, leads to a lozenge shaped sampling element on the sky, however, the centres of the lozenges lie on a regular and square grid, satisfying the Nyquist sampling criterion in both spatial directions.

  16. Integrated homeland security system with passive thermal imaging and advanced video analytics

    NASA Astrophysics Data System (ADS)

    Francisco, Glen; Tillman, Jennifer; Hanna, Keith; Heubusch, Jeff; Ayers, Robert

    2007-04-01

    A complete detection, management, and control security system is absolutely essential to preempting criminal and terrorist assaults on key assets and critical infrastructure. According to Tom Ridge, former Secretary of the US Department of Homeland Security, "Voluntary efforts alone are not sufficient to provide the level of assurance Americans deserve and they must take steps to improve security." Further, it is expected that Congress will mandate private sector investment of over $20 billion in infrastructure protection between 2007 and 2015, which is incremental to funds currently being allocated to key sites by the department of Homeland Security. Nearly 500,000 individual sites have been identified by the US Department of Homeland Security as critical infrastructure sites that would suffer severe and extensive damage if a security breach should occur. In fact, one major breach in any of 7,000 critical infrastructure facilities threatens more than 10,000 people. And one major breach in any of 123 facilities-identified as "most critical" among the 500,000-threatens more than 1,000,000 people. Current visible, nightvision or near infrared imaging technology alone has limited foul-weather viewing capability, poor nighttime performance, and limited nighttime range. And many systems today yield excessive false alarms, are managed by fatigued operators, are unable to manage the voluminous data captured, or lack the ability to pinpoint where an intrusion occurred. In our 2006 paper, "Critical Infrastructure Security Confidence Through Automated Thermal Imaging", we showed how a highly effective security solution can be developed by integrating what are now available "next-generation technologies" which include: Thermal imaging for the highly effective detection of intruders in the dark of night and in challenging weather conditions at the sensor imaging level - we refer to this as the passive thermal sensor level detection building block Automated software detection

  17. Advanced microlens and color filter process technology for the high-efficiency CMOS and CCD image sensors

    NASA Astrophysics Data System (ADS)

    Fan, Yang-Tung; Peng, Chiou-Shian; Chu, Cheng-Yu

    2000-12-01

    New markets are emerging for digital electronic image device, especially in visual communications, PC camera, mobile/cell phone, security system, toys, vehicle image system and computer peripherals for document capture. To enable one-chip image system that image sensor is with a full digital interface, can make image capture devices in our daily lives. Adding a color filter to such image sensor in a pattern of mosaics pixel or wide stripes can make image more real and colorful. We can say 'color filter makes the life more colorful color filter is? Color filter means can filter image light source except the color with specific wavelength and transmittance that is same as color filter itself. Color filter process is coating and patterning green, red and blue (or cyan, magenta and yellow) mosaic resists onto matched pixel in image sensing array pixels. According to the signal caught from each pixel, we can figure out the environment image picture. Widely use of digital electronic camera and multimedia applications today makes the feature of color filter becoming bright. Although it has challenge but it is very worthy to develop the process of color filter. We provide the best service on shorter cycle time, excellent color quality, high and stable yield. The key issues of advanced color process have to be solved and implemented are planarization and micro-lens technology. Lost of key points of color filter process technology have to consider will also be described in this paper.

  18. Novel genotype-phenotype associations in human cancers enabled by advanced molecular platforms and computational analysis of whole slide images

    PubMed Central

    Cooper, Lee A.D.; Kong, Jun; Gutman, David A.; Dunn, William D.; Nalisnik, Michael; Brat, Daniel J.

    2014-01-01

    Technological advances in computing, imaging and genomics have created new opportunities for exploring relationships between histology, molecular events and clinical outcomes using quantitative methods. Slide scanning devices are now capable of rapidly producing massive digital image archives that capture histological details in high-resolution. Commensurate advances in computing and image analysis algorithms enable mining of archives to extract descriptions of histology, ranging from basic human annotations to automatic and precisely quantitative morphometric characterization of hundreds of millions of cells. These imaging capabilities represent a new dimension in tissue-based studies, and when combined with genomic and clinical endpoints, can be used to explore biologic characteristics of the tumor microenvironment and to discover new morphologic biomarkers of genetic alterations and patient outcomes. In this paper we review developments in quantitative imaging technology and illustrate how image features can be integrated with clinical and genomic data to investigate fundamental problems in cancer. Using motivating examples from the study of glioblastomas (GBMs), we demonstrate how public data from The Cancer Genome Atlas (TCGA) can serve as an open platform to conduct in silico tissue based studies that integrate existing data resources. We show how these approaches can be used to explore the relation of the tumor microenvironment to genomic alterations and gene expression patterns and to define nuclear morphometric features that are predictive of genetic alterations and clinical outcomes. Challenges, limitations and emerging opportunities in the area of quantitative imaging and integrative analyses are also discussed. PMID:25599536

  19. Advanced magnetic resonance spectroscopy and imaging techniques applied to brain development and animal models of perinatal injury.

    PubMed

    van de Looij, Yohan; Dean, Justin M; Gunn, Alistair J; Hüppi, Petra S; Sizonenko, Stéphane V

    2015-10-01

    Magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) are widely used in the field of brain development and perinatal brain injury. Due to technical progress the magnetic field strength (B0) of MR systems has continuously increased, favoring (1)H-MRS with quantification of up to 18 metabolites in the brain and short echo time (TE) MRI sequences including phase and susceptibility imaging. For longer TE techniques including diffusion imaging modalities, the benefits of higher B0 have not been clearly established. Nevertheless, progress has also been made in new advanced diffusion models that have been developed to enhance the accuracy and specificity of the derived diffusion parameters. In this review, we will describe the latest developments in MRS and MRI techniques, including high-field (1)H-MRS, phase and susceptibility imaging, and diffusion imaging, and discuss their application in the study of cerebral development and perinatal brain injury.

  20. Advances in molecular imaging of atherosclerosis and myocardial infarction: shedding new light on in vivo cardiovascular biology

    PubMed Central

    Andia, Marcelo E.; Shah, Ajay M.; Botnar, René M.

    2012-01-01

    Molecular imaging of the cardiovascular system heavily relies on the development of new imaging probes and technologies to facilitate visualization of biological processes underlying or preceding disease. Molecular imaging is a highly active research discipline that has seen tremendous growth over the past decade. It has broadened our understanding of oncologic, neurologic, and cardiovascular diseases by providing new insights into the in vivo biology of disease progression and therapeutic interventions. As it allows for the longitudinal evaluation of biological processes, it is ideally suited for monitoring treatment response. In this review, we will concentrate on the major accomplishments and advances in the field of molecular imaging of atherosclerosis and myocardial infarction with a special focus on magnetic resonance imaging. PMID:23064836

  1. EPS in Environmental Microbial Biofilms as Examined by Advanced Imaging Techniques

    NASA Astrophysics Data System (ADS)

    Neu, T. R.; Lawrence, J. R.

    2006-12-01

    Biofilm communities are highly structured associations of cellular and polymeric components which are involved in biogenic and geogenic environmental processes. Furthermore, biofilms are also important in medical (infection), industrial (biofouling) and technological (biofilm engineering) processes. The interfacial microbial communities in a specific habitat are highly dynamic and change according to the environmental parameters affecting not only the cellular but also the polymeric constituents of the system. Through their EPS biofilms interact with dissolved, colloidal and particulate compounds from the bulk water phase. For a long time the focus in biofilm research was on the cellular constituents in biofilms and the polymer matrix in biofilms has been rather neglected. The polymer matrix is produced not only by different bacteria and archaea but also by eukaryotic micro-organisms such as algae and fungi. The mostly unidentified mixture of EPS compounds is responsible for many biofilm properties and is involved in biofilm functionality. The chemistry of the EPS matrix represents a mixture of polymers including polysaccharides, proteins, nucleic acids, neutral polymers, charged polymers, amphiphilic polymers and refractory microbial polymers. The analysis of the EPS may be done destructively by means of extraction and subsequent chemical analysis or in situ by means of specific probes in combination with advanced imaging. In the last 15 years laser scanning microscopy (LSM) has been established as an indispensable technique for studying microbial communities. LSM with 1-photon and 2-photon excitation in combination with fluorescence techniques allows 3-dimensional investigation of fully hydrated, living biofilm systems. This approach is able to reveal data on biofilm structural features as well as biofilm processes and interactions. The fluorescent probes available allow the quantitative assessment of cellular as well as polymer distribution. For this purpose

  2. Characterization of a linear device developed for research on advanced plasma imaging and dynamics

    SciTech Connect

    Chung, J.; Lee, K. D.; Seo, D. C.; Nam, Y. U.; Choi, M. C.

    2010-10-15

    Within the scope of long term research on imaging diagnostics for steady-state plasmas and understanding of edge plasma physics through diagnostics with conventional spectroscopic methods, we have constructed a linear electron cyclotron resonance (ECR) plasma device named Research on Advanced Plasma Imaging and Dynamics (RAPID). It has a variety of axial magnetic field profiles provided by eight water-cooled magnetic coils and two dc power supplies. The positions of the magnetic coils are freely adjustable along the axial direction and the power supplies can be operated with many combinations of electrical wiring to the coils. Here, a 6 kW 2.45 GHz magnetron is used to produce steady-state hydrogen, helium, and argon plasmas with central magnetic fields of 875 and/or 437.5 G (second harmonic). In order to achieve the highest possible plasma performance within the limited input parameters, wall conditioning experiments were carried out. Chamber bake-out was achieved with heating coils that were wound covering the vessel, and long-pulse electron cyclotron heating discharge cleaning was also followed after 4 days of bake-out. A uniform bake-out temperature (150 deg. C) was achieved by wrapping the vessel in high temperature thermal insulation textile and by controlling the heating coil current using a digital control system. The partial pressure changes were observed using a residual gas analyzer, and a total system pressure of 5x10{sup -8} Torr was finally reached. Diagnostic systems including a millimeter-wave interferometer, a high resolution survey spectrometer, a Langmuir probe, and an ultrasoft x-ray detector were used to provide the evidence that the plasma performance was improved as we desired. In this work, we present characterization of the RAPID device for various system conditions and configurations.

  3. Arctic sea ice leads from advanced very high resolution radiometer images

    NASA Technical Reports Server (NTRS)

    Lindsay, R. W.; Rothrock, D. A.

    1995-01-01

    A large number of advanced very high resolution radiometer (AVHRR) images from throughout 1989 are analyzed to determine lead characteristics. The units of analysis are square 200-km cells, and there are 270 such cells in the data set. Clouds are masked manually. Leads determine from images of the potential open water delta, a scaled version of the surface temperature or albedo that weights thin ice by its thermal or brightness impact. The lead fraction is determined as the mean delta, the monthly mean lead fraction ranges from 0.02 in winter to 0.06 in summer in the central Arctic and is near 0.08 in the winter in the peripheral seas. A method of accounting for lead width sampling errors due to the finite sample areas is introduced. In the central Arctic the observed mean lead width for a threshold of delta = 0.1 ranges from 2 or 3 km (near the resolution of the instrument) in the winter to 6 km in the summer. In the peripheral seas it is about 5 km in the winter. Width distributions are often more heavily weighted in the tail than exponential distributions and are well approximated by a power law. The along-track, number density power law N = aw(exp -6) has a mean exponent of b = 1.60 (standard deviation 0.18) and shows some seasonal variability. Mean floe widths in the central Arctic are 40 to 50 km in the winter, dropping to about 10 km in the summer. For floes the power law has a mean exponent of 0.93 and exhibits a clearer annual cycle. Lead orientation is determined with a method based on the direction of maximum extent.

  4. Characterization of a linear device developed for research on advanced plasma imaging and dynamics.

    PubMed

    Chung, J; Lee, K D; Seo, D C; Nam, Y U; Choi, M C

    2010-10-01

    Within the scope of long term research on imaging diagnostics for steady-state plasmas and understanding of edge plasma physics through diagnostics with conventional spectroscopic methods, we have constructed a linear electron cyclotron resonance (ECR) plasma device named Research on Advanced Plasma Imaging and Dynamics (RAPID). It has a variety of axial magnetic field profiles provided by eight water-cooled magnetic coils and two dc power supplies. The positions of the magnetic coils are freely adjustable along the axial direction and the power supplies can be operated with many combinations of electrical wiring to the coils. Here, a 6 kW 2.45 GHz magnetron is used to produce steady-state hydrogen, helium, and argon plasmas with central magnetic fields of 875 and/or 437.5 G (second harmonic). In order to achieve the highest possible plasma performance within the limited input parameters, wall conditioning experiments were carried out. Chamber bake-out was achieved with heating coils that were wound covering the vessel, and long-pulse electron cyclotron heating discharge cleaning was also followed after 4 days of bake-out. A uniform bake-out temperature (150 °C) was achieved by wrapping the vessel in high temperature thermal insulation textile and by controlling the heating coil current using a digital control system. The partial pressure changes were observed using a residual gas analyzer, and a total system pressure of 5×10(-8) Torr was finally reached. Diagnostic systems including a millimeter-wave interferometer, a high resolution survey spectrometer, a Langmuir probe, and an ultrasoft x-ray detector were used to provide the evidence that the plasma performance was improved as we desired. In this work, we present characterization of the RAPID device for various system conditions and configurations.

  5. Strategic steps for advanced molecular imaging with magnetic resonance-based diagnostic modalities.

    PubMed

    Belkic, Dž; Belkic, K

    2015-02-01

    With the rapidly-expanding sophistication in our understanding of cancer cell biology, molecular imaging offers a critical bridge to oncology. Molecular imaging through magnetic resonance spectroscopy (MRS) can provide information about many metabolites at the same time. Since MRS entails no ionizing radiation, repeated monitoring, including screening can be performed. However, MRS via the fast Fourier transform (FFT) has poor resolution and signal-to-noise ratio (SNR). Moreover, subjective and non-unique (ambiguous) fittings of FFT spectra cannot provide reliable quantification of clinical usefulness. In sharp contrast, objective and unique (unambiguous) signal processing by the fast Padé transform (FPT) can increase resolution and retrieve the true quantitative metabolic information. To illustrate, we apply the FPT to in vitro MRS data as encoded from malignant ovarian cyst fluid and perform detailed analysis. This problem area is particularly in need of timely diagnostics by more advanced modalities, such as high-resolution MRS, since conventional methods usually detect ovarian cancers at late stages with poor prognosis, whereas at an early stage the prognosis is excellent. The reliability and robustness of the FPT is assessed for time signals contaminated with varying noise levels. In the presence of higher background noise, all physical metabolites were unequivocally identified and their concentrations precisely extracted, using small fractions of the total signal length. Via the "signal-noise separation" concept alongside the "stability test", all non-physical information was binned, such that fully denoised spectra were generated. These results imply that a reformulation of data acquisition is needed, as guided by the FPT in MRS, since a small number of short transient time signals can provide high resolution and good SNR. This would enhance the diagnostic accuracy of MRS and shorten examination times, thereby improving efficiency and cost-effectiveness of

  6. Assessment of the Utility of the Advanced Himawari Imager to Detect Active Fire Over Australia

    NASA Astrophysics Data System (ADS)

    Hally, B.; Wallace, L.; Reinke, K.; Jones, S.

    2016-06-01

    Wildfire detection and attribution is an issue of importance due to the socio-economic impact of fires in Australia. Early detection of fires allows emergency response agencies to make informed decisions in order to minimise loss of life and protect strategic resources in threatened areas. Until recently, the ability of land management authorities to accurately assess fire through satellite observations of Australia was limited to those made by polar orbiting satellites. The launch of the Japan Meteorological Agency (JMA) Himawari-8 satellite, with the 16-band Advanced Himawari Imager (AHI-8) onboard, in October 2014 presents a significant opportunity to improve the timeliness of satellite fire detection across Australia. The near real-time availability of images, at a ten minute frequency, may also provide contextual information (background temperature) leading to improvements in the assessment of fire characteristics. This paper investigates the application of the high frequency observation data supplied by this sensor for fire detection and attribution. As AHI-8 is a new sensor we have performed an analysis of the noise characteristics of the two spectral bands used for fire attribution across various land use types which occur in Australia. Using this information we have adapted existing algorithms, based upon least squares error minimisation and Kalman filtering, which utilise high frequency observations of surface temperature to detect and attribute fire. The fire detection and attribution information provided by these algorithms is then compared to existing satellite based fire products as well as in-situ information provided by land management agencies. These comparisons were made Australia-wide for an entire fire season - including many significant fire events (wildfires and prescribed burns). Preliminary detection results suggest that these methods for fire detection perform comparably to existing fire products and fire incident reporting from relevant

  7. Dual wavelength imaging of a scrape-off layer in an advanced beam-driven field-reversed configuration

    NASA Astrophysics Data System (ADS)

    Osin, D.; Schindler, T.

    2016-11-01

    A dual wavelength imaging system has been developed and installed on C-2U to capture 2D images of a He jet in the Scrape-Off Layer (SOL) of an advanced beam-driven Field-Reversed Configuration (FRC) plasma. The system was designed to optically split two identical images and pass them through 1 nm FWHM filters. Dual wavelength images are focused adjacent on a large format CCD chip and recorded simultaneously with a time resolution down to 10 μs using a gated micro-channel plate. The relatively compact optical system images a 10 cm plasma region with a spatial resolution of 0.2 cm and can be used in a harsh environment with high electro-magnetic noise and high magnetic field. The dual wavelength imaging system provides 2D images of either electron density or temperature by observing spectral line pairs emitted by He jet atoms in the SOL. A large field of view, combined with good space and time resolution of the imaging system, allows visualization of macro-flows in the SOL. First 2D images of the electron density and temperature observed in the SOL of the C-2U FRC are presented.

  8. A Vision of Quantitative Imaging Technology for Validation of Advanced Flight Technologies

    NASA Technical Reports Server (NTRS)

    Horvath, Thomas J.; Kerns, Robert V.; Jones, Kenneth M.; Grinstead, Jay H.; Schwartz, Richard J.; Gibson, David M.; Taylor, Jeff C.; Tack, Steve; Dantowitz, Ronald F.

    2011-01-01

    Flight-testing is traditionally an expensive but critical element in the development and ultimate validation and certification of technologies destined for future operational capabilities. Measurements obtained in relevant flight environments also provide unique opportunities to observe flow phenomenon that are often beyond the capabilities of ground testing facilities and computational tools to simulate or duplicate. However, the challenges of minimizing vehicle weight and internal complexity as well as instrumentation bandwidth limitations often restrict the ability to make high-density, in-situ measurements with discrete sensors. Remote imaging offers a potential opportunity to noninvasively obtain such flight data in a complementary fashion. The NASA Hypersonic Thermodynamic Infrared Measurements Project has demonstrated such a capability to obtain calibrated thermal imagery on a hypersonic vehicle in flight. Through the application of existing and accessible technologies, the acreage surface temperature of the Shuttle lower surface was measured during reentry. Future hypersonic cruise vehicles, launcher configurations and reentry vehicles will, however, challenge current remote imaging capability. As NASA embarks on the design and deployment of a new Space Launch System architecture for access beyond earth orbit (and the commercial sector focused on low earth orbit), an opportunity exists to implement an imagery system and its supporting infrastructure that provides sufficient flexibility to incorporate changing technology to address the future needs of the flight test community. A long term vision is offered that supports the application of advanced multi-waveband sensing technology to aid in the development of future aerospace systems and critical technologies to enable highly responsive vehicle operations across the aerospace continuum, spanning launch, reusable space access and global reach. Motivations for development of an Agency level imagery

  9. 89Zr-cetuximab PET imaging in patients with advanced colorectal cancer

    PubMed Central

    Huisman, Marc C.; Vugts, Danielle J.; Roth, Chantal; Luik, Anne Marije; Mulder, Emma R.; Schuit, Robert C.; Boellaard, Ronald; Hoekstra, Otto S.; van Dongen, Guus AMS; Verheul, Henk M.W.

    2015-01-01

    Monoclonal antibodies (mAbs) against the epidermal growth factor receptor (EGFR) are used in the treatment of advanced colorectal cancer (mCRC). Approximately 50% of patients benefit despite patient selection for RAS wild type (wt) tumors. Based on the hypothesis that tumor targeting is required for clinical benefit of anti-EGFR treatment, biodistribution and tumor uptake of 89Zr-cetuximab by Positron Emission Tomography (PET), combining the sensitivity of PET with the specificity of cetuximab for EGFR was evaluated. Ten patients with wt K-RAS mCRC received 37 ± 1 MBq 89Zr-cetuximab directly (<2 h) after the first therapeutic dose of cetuximab. PET-scans were performed from 1 hour to 10 days post injection (p.i.). Biodistribution was determined for blood and organs. Uptake in tumor lesions was quantified by Standardized Uptake Value (SUV) and related to response. In 6 of 10 patients 89Zr-cetuximab uptake in tumor lesions was detected. Four of 6 patients with 89Zr-cetuximab uptake had clinical benefit, while progressive disease was observed in 3 of 4 patients without 89Zr-cetuximab uptake. Taken together, tumor uptake of 89Zr-cetuximab can be visualized by PET imaging. The strong relation between uptake and response warrants further clinical validation as an innovative selection method for cetuximab treatment in patients with wt RAS mCRC. PMID:26309164

  10. Descriptions of a linear device developed for research on advanced plasma imaging and dynamics

    SciTech Connect

    Chung, J.; Lee, K. D.; Seo, D. C.; Nam, Y. U.; Ko, W. H.; Lee, J. H.; Choi, M. C.

    2009-10-15

    The research on advanced plasma imaging and dynamics (RAPID) device is a newly developed linear electron cyclotron resonance (ECR) plasma device. It has a variety of axial magnetic field profiles provided by eight water-cooled magnetic coils and two dc power supplies. The positions of the magnetic coils are freely adjustable along the axial direction and the power supplies can be operated with many combinations of electrical wiring to the coils. A 6 kW 2.45 GHz magnetron is used to produce steady-state ECR plasmas with central magnetic fields of 875 and/or 437.5 G (second harmonic). The cylindrical stainless steel vacuum chamber is 300 mm in diameter and 750 mm in length and has eight radial and ten axial ports including 6-in. and 8-in. viewing windows for heating and diagnostics. Experimental observation of ECR plasma heating has been recently carried out during the initial plasma operation. The main diagnostic systems including a 94 GHz heterodyne interferometer, a high-resolution 25 channel one-dimensional array spectrometer, a single channel survey spectrometer, and an electric probe have been also prepared. The RAPID device is a flexible simulator for the understanding of tokamak edge plasma physics and new diagnostic system development. In this work, we describe the RAPID device and initial operation results.

  11. Advanced Imaging Technologies for the Detection of Dysplasia and Early Cancer in Barrett Esophagus

    PubMed Central

    Espino, Alberto; Cirocco, Maria; DaCosta, Ralph

    2014-01-01

    Advanced esophageal adenocarcinomas arising from Barrett esophagus (BE) are tumors with an increasing incidence and poor prognosis. The aim of endoscopic surveillance of BE is to detect dysplasia, particularly high-grade dysplasia and intramucosal cancers that can subsequently be treated endoscopically before progression to invasive cancer with lymph node metastases. Current surveillance practice standards require the collection of random 4-quadrant biopsy specimens over every 1 to 2 cm of BE (Seattle protocol) to detect dysplasia with the assistance of white light endoscopy, in addition to performing targeted biopsies of recognizable lesions. This approach is labor-intensive but should currently be considered state of the art. Chromoendoscopy, virtual chromoendoscopy (e.g., narrow band imaging), and confocal laser endomicroscopy, in addition to high-definition standard endoscopy, might increase the diagnostic yield for the detection of dysplastic lesions. Until these modalities have been demonstrated to enhance efficiency or cost effectiveness, the standard protocol will remain careful examination using conventional off the shelf high-resolution endoscopes, combined with as longer inspection time which is associated with increased detection of dysplasia. PMID:24570883

  12. 89Zr-cetuximab PET imaging in patients with advanced colorectal cancer.

    PubMed

    Menke-van der Houven van Oordt, Catharina Willemien; Gootjes, Elske C; Huisman, Marc C; Vugts, Danielle J; Roth, Chantal; Luik, Anne Marije; Mulder, Emma R; Schuit, Robert C; Boellaard, Ronald; Hoekstra, Otto S; van Dongen, Guus Ams; Verheul, Henk M W

    2015-10-01

    Monoclonal antibodies (mAbs) against the epidermal growth factor receptor (EGFR) are used in the treatment of advanced colorectal cancer (mCRC). Approximately 50% of patients benefit despite patient selection for RAS wild type (wt) tumors. Based on the hypothesis that tumor targeting is required for clinical benefit of anti-EGFR treatment, biodistribution and tumor uptake of (89)Zr-cetuximab by Positron Emission Tomography (PET), combining the sensitivity of PET with the specificity of cetuximab for EGFR was evaluated. Ten patients with wt K-RAS mCRC received 37 ± 1 MBq (89)Zr-cetuximab directly (<2 h) after the first therapeutic dose of cetuximab. PET-scans were performed from 1 hour to 10 days post injection (p.i.). Biodistribution was determined for blood and organs. Uptake in tumor lesions was quantified by Standardized Uptake Value (SUV) and related to response. In 6 of 10 patients (89)Zr-cetuximab uptake in tumor lesions was detected. Four of 6 patients with (89)Zr-cetuximab uptake had clinical benefit, while progressive disease was observed in 3 of 4 patients without (89)Zr-cetuximab uptake. Taken together, tumor uptake of 89Zr-cetuximab can be visualized by PET imaging. The strong relation between uptake and response warrants further clinical validation as an innovative selection method for cetuximab treatment in patients with wt RAS mCRC.

  13. Big Heart Data: Advancing Health Informatics through Data Sharing in Cardiovascular Imaging

    PubMed Central

    Suinesiaputra, Avan; Medrano-Gracia, Pau; Cowan, Brett R.; Young, Alistair A.

    2015-01-01

    The burden of heart disease is rapidly worsening due to increasing prevalence of obesity and diabetes. Data sharing and open database resources for heart health informatics are important for advancing our understanding of cardiovascular function, disease progression and therapeutics. Data sharing enables valuable information, often obtained at considerable expense and effort, to be re-used beyond the specific objectives of the original study. Many government funding agencies and journal publishers are requiring data re-use, and are providing mechanisms for data curation and archival. Tools and infrastructure are available to archive anonymous data from a wide range of studies, from descriptive epidemiological data to gigabytes of imaging data. Meta-analyses can be performed to combine raw data from disparate studies to obtain unique comparisons or to enhance statistical power. Open benchmark datasets are invaluable for validating data analysis algorithms and objectively comparing results. This review provides a rationale for increased data sharing and surveys recent progress in the cardiovascular domain. We also highlight the potential of recent large cardiovascular epidemiological studies enabling collaborative efforts to facilitate data sharing, algorithms benchmarking, disease modeling and statistical atlases. PMID:25415993

  14. Focal Plane Detectors for the Advanced Gamma-Ray Imaging System (AGIS)

    SciTech Connect

    Otte, A. N.; Williams, D. A.; Byrum, K.; Drake, G.; Horan, D.; Smith, A.; Wagner, R. G.; Falcone, A.; Funk, S.; Tajima, H.; Mukherjee, R.

    2008-12-24

    The Advanced Gamma-Ray Imaging System (AGIS) is a concept for the next generation observatory in ground-based very high energy gamma-ray astronomy. Design goals are ten times better sensitivity, higher angular resolution, and a lower energy threshold than existing Cherenkov telescopes. Simulations show that a substantial improvement in angular resolution may be achieved if the pixel diameter is reduced to the order of 0.05 deg, i.e. two to three times smaller than the pixel diameter of current Cherenkov telescope cameras. At these dimensions, photon detectors with smaller physical dimensions can be attractive alternatives to the classical photomultiplier tube (PMT). Furthermore, the operation of an experiment with the size of AGIS requires photon detectors that are among other things more reliable, more durable, and possibly higher efficiency photon detectors. Alternative photon detectors we are considering for AGIS include both silicon photomultipliers (SiPMs) and multi-anode photomultipliers (MAPMTs). Here we present results from laboratory testing of MAPMTs and SiPMs along with results from the first incorporation of these devices into cameras on test bed Cherenkov telescopes.

  15. Upgrades of the high resolution imaging x-ray crystal spectrometers on experimental advanced superconducting tokamak

    SciTech Connect

    Lu, B.; Wang, F.; Fu, J.; Li, Y.; Wan, B.; Shi, Y.; Bitter, M.; Hill, K. W.; Lee, S. G.

    2012-10-15

    Two imaging x-ray crystal spectrometers, the so-called 'poloidal' and 'tangential' spectrometers, were recently implemented on experimental advanced superconducting tokamak (EAST) to provide spatially and temporally resolved impurity ion temperature (T{sub i}), electron temperature (T{sub e}) and rotation velocity profiles. They are derived from Doppler width of W line for Ti, the intensity ratio of Li-like satellites to W line for Te, and Doppler shift of W line for rotation. Each spectrometer originally consisted of a spherically curved crystal and a two-dimensional multi-wire proportional counter (MWPC) detector. Both spectrometers have now been upgraded. The layout of the tangential spectrometer was modified, since it had to be moved to a different port, and the spectrometer was equipped with two high count rate Pilatus detectors (Model 100 K) to overcome the count rate limitation of the MWPC and to improve its time resolution. The poloidal spectrometer was equipped with two spherically bent crystals to record the spectra of He-like and H-like argon simultaneously and side by side on the original MWPC. These upgrades are described, and new results from the latest EAST experimental campaign are presented.

  16. Radiometric calibration of Advanced Land Imager using reflectance-based results between 2001 and 2005

    NASA Astrophysics Data System (ADS)

    McCorkel, J.; Thome, K.; Biggar, S.; Kuester, M.

    2006-08-01

    The Landsat series of sensors have supplied the remote sensing community with a continuous data set dating to the early 1970s. An important aspect of retaining the continuity of these data is that a Landsat follow-on as well as current Landsat instruments must be understood radiometrically throughout their mission. The Advanced Land Imager (ALI), for example, was developed as a prototype for the next generation of Landsat Instruments, and as such there was a significant effort to understand its radiometric characteristics as well as how it compares with previous Landsat sensors. The Remote Sensing Group at the University of Arizona has been part of this effort since the late 2000 launch of ALI through the use of the reflectance-based method of vicarious calibration. The reflectance-based approach consists of ground-based measurements of atmospheric conditions and surface reflectance at the time of satellite overpass to predict the at-sensor radiance seen by the sensor under study. The work compares results from the reflectance-based approach obtained from well-characterized test sites such as Railroad Valley Playa in Nevada and Ivanpah Playa in California as applied to ALI, Landsat-5 TM, and Landsat-7 EMT+. The results from the comparison use a total of 14 ALI dates spanning in time from 2001 to late 2005 and show that ALI agrees with the current radiometric results from TM and ETM+ to within 5%.

  17. Big heart data: advancing health informatics through data sharing in cardiovascular imaging.

    PubMed

    Suinesiaputra, Avan; Medrano-Gracia, Pau; Cowan, Brett R; Young, Alistair A

    2015-07-01

    The burden of heart disease is rapidly worsening due to the increasing prevalence of obesity and diabetes. Data sharing and open database resources for heart health informatics are important for advancing our understanding of cardiovascular function, disease progression and therapeutics. Data sharing enables valuable information, often obtained at considerable expense and effort, to be reused beyond the specific objectives of the original study. Many government funding agencies and journal publishers are requiring data reuse, and are providing mechanisms for data curation and archival. Tools and infrastructure are available to archive anonymous data from a wide range of studies, from descriptive epidemiological data to gigabytes of imaging data. Meta-analyses can be performed to combine raw data from disparate studies to obtain unique comparisons or to enhance statistical power. Open benchmark datasets are invaluable for validating data analysis algorithms and objectively comparing results. This review provides a rationale for increased data sharing and surveys recent progress in the cardiovascular domain. We also highlight the potential of recent large cardiovascular epidemiological studies enabling collaborative efforts to facilitate data sharing, algorithms benchmarking, disease modeling and statistical atlases. PMID:25415993

  18. Advanced image analysis of the surface pattern emerging in Ni3Al intermetallic alloys on anodization

    NASA Astrophysics Data System (ADS)

    Salerno, Marco; Stępniowski, Wojciech; Cieślak, Grzegorz; Norek, Małgorzata; Michalska-Domańska, Marta; Karczewski, Krzysztof; Chilimoniuk, Paulina; Polkowski, Wojciech; Jóźwik, Paweł; Bojar, Zbigniew

    2016-07-01

    Anodization of Ni3Al alloy is of interest in the field of industrial manufacturing, thanks to the formation of protective oxide layer on the materials working in corrosive environments and high temperatures. However, homogeneous surface treatment is paramount for technological applications of this material. The anodization conditions have to be set outside the ranges of corrosion and “burning”, which is the electric field enhanced anodic dissolution of the metal. In order to check against occurrence of these events, proper quantitative means for assessing the surface quality have to be developed and established. We approached this task by advanced analysis of scanning electron microscope images of anodized Ni3Al plates. The anodization was carried out in 0.3 M citric acid at two temperatures of 0 and 30°C and at voltages in the range of 2 12 V. Different figures can be used to characterize the quality of the surface, in terms of uniformity. Here, the concept of regularity ratio spread is used for the first time on surfaces of technological interest. Additionally, the Minkowski parameters have been calculated and their meaning is discussed.

  19. The Advanced Gamma-ray Imaging System (AGIS)--Science Highlights

    SciTech Connect

    Buckley, J.; Krawczynski, H.; Coppi, P.; Digel, S.; Funk, S.; Krennrich, F.; Pohl, M.; Romani, R.; Vassiliev, V.

    2008-12-24

    The Advanced Gamma-ray Imaging System (AGIS), a future gamma-ray telescope consisting of an array of {approx}50 atmospheric Cherenkov telescopes distributed over an area of {approx}1 km{sup 2}, will provide a powerful new tool for exploring the high-energy universe. The order-of-magnitude increase in sensitivity and improved angular resolution could provide the first detailed images of {gamma}-ray emission from other nearby galaxies or galaxy clusters. The large effective area will provide unprecedented sensitivity to short transients (such as flares from AGNs and GRBs) probing both intrinsic spectral variability (revealing the details of the acceleration mechanism and geometry) as well as constraining the high-energy dispersion in the velocity of light (probing the structure of spacetime and Lorentz invariance). A wide field of view ({approx}4 times that of current instruments) and excellent angular resolution (several times better than current instruments) will allow for an unprecedented survey of the Galactic plane, providing a deep unobscured survey of SNRs, X-ray binaries, pulsar-wind nebulae, molecular cloud complexes and other sources. The differential flux sensitivity of {approx}10{sup -13} erg cm{sup -2} sec{sup -1} will rival the most sensitive X-ray instruments for these extended Galactic sources. The excellent capabilities of AGIS at energies below 100 GeV will provide sensitivity to AGN and GRBs out to cosmological redshifts, increasing the number of AGNs detected at high energies from about 20 to more than 100, permitting population studies that will provide valuable insights into both a unified model for AGN and a detailed measurement of the effects of intergalactic absorption from the diffuse extragalactic background light. A new instrument with fast-slewing wide-field telescopes could provide detections of a number of long-duration GRBs providing important physical constraints from this new spectral component. The new array will also have excellent

  20. Imaging evidence for Hubbard Glacier advances and retreats since the last glacial maximum in Yakutat and Disenchantment Bays, Alaska

    NASA Astrophysics Data System (ADS)

    Zurbuchen, Julie M.; Gulick, Sean P. S.; Walton, Maureen A. L.; Goff, John A.

    2015-06-01

    High-resolution 2-D multichannel seismic data, collected during the 2012 UTIG-USGS National Earthquake Hazards Reduction Program survey of Disenchantment and Yakutat Bays in southeast Alaska, provide insight into their glacial history. These data show evidence of two unconformities, appearing in the form of channels, and are interpreted to be advance pathways for Hubbard Glacier. The youngest observable channel, thought to have culminated near the main phase of the Little Ice Age (LIA), is imaged in Disenchantment Bay and ends at a terminal moraine near Blizhni Point. An older channel, thought to be from an advance that culminated in the early phase of the LIA, extends from Disenchantment Bay into the northeastern edge of Yakutat Bay, turning southward at Knight Island and terminating on the southeastern edge of Yakutat Bay. Our interpretation is that Hubbard Glacier has repeatedly advanced around the east side of Yakutat Bay in Knight Island Channel, possibly due to the presence of Malaspina Glacier cutting off access to central Yakutat Bay during times of mutual advance. We observe two distinct erosional surfaces and retreat sequences of Hubbard Glacier in Yakutat Bay, supporting the hypothesis that minor glacial advances in fjords do not erode all prior sediment accumulations. Interpretation of chaotic seismic facies between these two unconformities suggests that Hubbard Glacier exhibits rapid retreats and that Disenchantment Bay is subject to numerous episodes of outburst flooding and morainal bank collapse. These findings also suggest that tidewater glaciers preferentially reoccupy the same channels in bay and marine settings during advances.

  1. Automated hotspot analysis with aerial image CD metrology for advanced logic devices

    NASA Astrophysics Data System (ADS)

    Buttgereit, Ute; Trautzsch, Thomas; Kim, Min-ho; Seo, Jung-Uk; Yoon, Young-Keun; Han, Hak-Seung; Chung, Dong Hoon; Jeon, Chan-Uk; Meyers, Gary

    2014-09-01

    Continuously shrinking designs by further extension of 193nm technology lead to a much higher probability of hotspots especially for the manufacturing of advanced logic devices. The CD of these potential hotspots needs to be precisely controlled and measured on the mask. On top of that, the feature complexity increases due to high OPC load in the logic mask design which is an additional challenge for CD metrology. Therefore the hotspot measurements have been performed on WLCD from ZEISS, which provides the benefit of reduced complexity by measuring the CD in the aerial image and qualifying the printing relevant CD. This is especially of advantage for complex 2D feature measurements. Additionally, the data preparation for CD measurement becomes more critical due to the larger amount of CD measurements and the increasing feature diversity. For the data preparation this means to identify these hotspots and mark them automatically with the correct marker required to make the feature specific CD measurement successful. Currently available methods can address generic pattern but cannot deal with the pattern diversity of the hotspots. The paper will explore a method how to overcome those limitations and to enhance the time-to-result in the marking process dramatically. For the marking process the Synopsys WLCD Output Module was utilized, which is an interface between the CATS mask data prep software and the WLCD metrology tool. It translates the CATS marking directly into an executable WLCD measurement job including CD analysis. The paper will describe the utilized method and flow for the hotspot measurement. Additionally, the achieved results on hotspot measurements utilizing this method will be presented.

  2. State of the art: advanced imaging of the right ventricle and pulmonary circulation in humans (2013 Grover Conference series)

    PubMed Central

    2014-01-01

    Abstract Pulmonary arterial hypertension (PAH) is a progressive disease characterized by remodeling and vasoconstriction of the pulmonary vasculature, ultimately leading to right ventricular (RV) failure and death. Recent developments in echocardiography, cardiovascular magnetic resonance imaging, computed tomography, and positron emission tomography allow advanced, noninvasive, in vivo assessment of the RV and have contributed to the identification of risk factors, prognostic factors, and monitoring of therapeutic responses in patients with PAH. Although far from reaching its future potential, these techniques have not only provided global RV assessment but also allowed evaluation of changes in cellular and molecular tissue processes, such as metabolism, oxygen balance and ischemia, angiogenesis, and apoptosis. Integrated application of these techniques could provide full insights into the different pathophysiological aspects of a failing RV in the setting of PAH. Recent advances in hybrid imaging have implemented simultaneous measurements of myocardial and vascular interactions and will be one of the most important potential future developments. PMID:25006434

  3. Bio-image warehouse system: concept and implementation of a diagnosis-based data warehouse for advanced imaging modalities in neuroradiology.

    PubMed

    Minati, L; Ghielmetti, F; Ciobanu, V; D'Incerti, L; Maccagnano, C; Bizzi, A; Bruzzone, M G

    2007-03-01

    Advanced neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), chemical shift spectroscopy imaging (CSI), diffusion tensor imaging (DTI), and perfusion-weighted imaging (PWI) create novel challenges in terms of data storage and management: huge amounts of raw data are generated, the results of analysis may depend on the software and settings that have been used, and most often intermediate files are inherently not compliant with the current DICOM (digital imaging and communication in medicine) standard, as they contain multidimensional complex and tensor arrays and various other types of data structures. A software architecture, referred to as Bio-Image Warehouse System (BIWS), which can be used alongside a radiology information system/picture archiving and communication system (RIS/PACS) system to store neuroimaging data for research purposes, is presented. The system architecture is conceived with the purpose of enabling to query by diagnosis according to a predefined two-layered classification taxonomy. The operational impact of the system and the time needed to get acquainted with the web-based interface and with the taxonomy are found to be limited. The development of modules enabling automated creation of statistical templates is proposed.

  4. Compact Image Slicing Spectrometer (ISS) for hyperspectral fluorescence microscopy

    PubMed Central

    Gao, Liang; Kester, Robert T.; Tkaczyk, Tomasz S.

    2009-01-01

    An image slicing spectrometer (ISS) for microscopy applications is presented. Its principle is based on the redirecting of image zones by specially organized thin mirrors within a custom fabricated component termed an image slicer. The demonstrated prototype can simultaneously acquire a 140nm spectral range within its 2D field of view from a single image. The spectral resolution of the system is 5.6nm. The FOV and spatial resolution of the ISS depend on the selected microscope objective and for the results presented is 45×45μm2 and 0.45μm respectively. This proof-of-concept system can be easily improved in the future for higher (both spectral and spatial) resolution imaging. The system requires no scanning and minimal post data processing. In addition, the reflective nature of the image slicer and use of prisms for spectral dispersion make the system light efficient. Both of the above features are highly valuable for real time fluorescent-spectral imaging in biological and diagnostic applications. PMID:19654631

  5. Advanced multimodality imaging of inflammatory bowel disease in 2015: An update

    PubMed Central

    Stanley, Emma; Moriarty, Heather K; Cronin, Carmel G

    2016-01-01

    The diagnosis and effective management of inflammatory bowel disease (IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard for diagnosis of IBD, imaging plays a central role in the assessment of extra mural disease, in disease surveillance and in the assessment of response to medical treatments, which are often expensive. Imaging is also vital in the detection and diagnosis of disease related complications, both acute and chronic. In this review, we will describe, with illustrative images, the imaging features of IBD in adults, with emphasis on up-to-date imaging techniques focusing predominantly on cross sectional imaging and new magnetic resonance imaging techniques. PMID:27358684

  6. Advanced imaging techniques II: using a compound microscope for photographing point-mount specimens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Digital imaging technology has revolutionized the practice photographing insects for scientific study. Herein described are lighting and mounting techniques designed for imaging micro Hymenoptera. Techniques described here are applicable to all small insects, as well as other invertebrates. The ke...

  7. Transpersonal Psychology: Guiding Image for the Advancement of International Adult Education.

    ERIC Educational Resources Information Center

    Boucouvalas, Marcie

    1984-01-01

    The importance of guiding images is examined, along with analyses of the images of humankind and worldviews previously offered by psychology and adopted by society-at-large. The article focuses on the contribution of transpersonal psychology, the discipline's fourth force, which integrates and extends prior guiding images. (CT)

  8. Advances in three-dimensional integral imaging: sensing, display, and applications [Invited].

    PubMed

    Xiao, Xiao; Javidi, Bahram; Martinez-Corral, Manuel; Stern, Adrian

    2013-02-01

    Three-dimensional (3D) sensing and imaging technologies have been extensively researched for many applications in the fields of entertainment, medicine, robotics, manufacturing, industrial inspection, security, surveillance, and defense due to their diverse and significant benefits. Integral imaging is a passive multiperspective imaging technique, which records multiple two-dimensional images of a scene from different perspectives. Unlike holography, it can capture a scene such as outdoor events with incoherent or ambient light. Integral imaging can display a true 3D color image with full parallax and continuous viewing angles by incoherent light; thus it does not suffer from speckle degradation. Because of its unique properties, integral imaging has been revived over the past decade or so as a promising approach for massive 3D commercialization. A series of key articles on this topic have appeared in the OSA journals, including Applied Optics. Thus, it is fitting that this Commemorative Review presents an overview of literature on physical principles and applications of integral imaging. Several data capture configurations, reconstruction, and display methods are overviewed. In addition, applications including 3D underwater imaging, 3D imaging in photon-starved environments, 3D tracking of occluded objects, 3D optical microscopy, and 3D polarimetric imaging are reviewed. PMID:23385893

  9. Implementation of improved interactive image analysis at the Advanced Photon Source (APC) linac.

    SciTech Connect

    Arnold, N.

    1998-09-11

    An image-analysis system, based on commercially available data visualization software (IDL [1]), allows convenient interaction with image data while still providing calculated beam parameters at a rate of up to 2 Hz. Image data are transferred from the IOC to the workstation via EPICS [2] channel access. A custom EPICS record was created in order to overcome the channel access limit of 16k bytes per array. The user can conveniently calibrate optical transition radiation (OTR) and fluorescent screens, capture background images, acquire and average a series of images, and specify several other filtering and viewing options. The images can be saved in either IDL format or APS-standard format (SDDS [3]), allowing for rapid postprocessing of image data by numerous other software tools.

  10. Advances in Image Pre-Processing to Improve Automated 3d Reconstruction

    NASA Astrophysics Data System (ADS)

    Ballabeni, A.; Apollonio, F. I.; Gaiani, M.; Remondino, F.

    2015-02-01

    Tools and algorithms for automated image processing and 3D reconstruction purposes have become more and more available, giving the possibility to process any dataset of unoriented and markerless images. Typically, dense 3D point clouds (or texture 3D polygonal models) are produced at reasonable processing time. In this paper, we evaluate how the radiometric pre-processing of image datasets (particularly in RAW format) can help in improving the performances of state-of-the-art automated image processing tools. Beside a review of common pre-processing methods, an efficient pipeline based on color enhancement, image denoising, RGB to Gray conversion and image content enrichment is presented. The performed tests, partly reported for sake of space, demonstrate how an effective image pre-processing, which considers the entire dataset in analysis, can improve the automated orientation procedure and dense 3D point cloud reconstruction, even in case of poor texture scenarios.

  11. The GOES-R Advanced Baseline Imager: detector spectral response effects on thermal emissive band calibration

    NASA Astrophysics Data System (ADS)

    Pearlman, Aaron J.; Padula, Francis; Cao, Changyong; Wu, Xiangqian

    2015-10-01

    The Advanced Baseline Imager (ABI) will be aboard the National Oceanic and Atmospheric Administration's Geostationary Operational Environmental Satellite R-Series (GOES-R) to supply data needed for operational weather forecasts and long-term climate variability studies, which depend on high quality data. Unlike the heritage operational GOES systems that have two or four detectors per band, ABI has hundreds of detectors per channel requiring calibration coefficients for each one. This increase in number of detectors poses new challenges for next generation sensors as each detector has a unique spectral response function (SRF) even though only one averaged SRF per band is used operationally to calibrate each detector. This simplified processing increases computational efficiency. Using measured system-level SRF data from pre-launch testing, we have the opportunity to characterize the calibration impact using measured SRFs, both per detector and as an average of detector-level SRFs similar to the operational version. We calculated the spectral response impacts for the thermal emissive bands (TEB) theoretically, by simulating the ABI response viewing an ideal blackbody and practically, with the measured ABI response to an external reference blackbody from the pre-launch TEB calibration test. The impacts from the practical case match the theoretical results using an ideal blackbody. The observed brightness temperature trends show structure across the array with magnitudes as large as 0.1 K for and 12 (9.61 µm), and 0.25 K for band 14 (11.2 µm) for a 300 K blackbody. The trends in the raw ABI signal viewing the blackbody support the spectral response measurements results, since they show similar trends in bands 12 (9.61µm), and 14 (11.2 µm), meaning that the spectral effects dominate the response differences between detectors for these bands. We further validated these effects using the radiometric bias calculated between calibrations using the external blackbody and

  12. Studies on the Synergy of TEMPO/GEO-CAPE with GOES-R Advanced Baseline Imager

    NASA Astrophysics Data System (ADS)

    Ciren, P.; Kondragunta, S.

    2015-12-01

    TEMPO (Tropospheric Emissions: Monitoring of Pollution) is a space-borne UV-spectral radiometer to be flown in a geostationary orbit as part of NASA's Earth Venture program. NASA also is planning a decadal survey mission-The GEOstationary Coastal and Air Pollution Events (GEO-CAPE). However, NASA has initiated scientific studies to determine if TEMPO can meet both its and GEO-CAPE's requirements by synergistically retrieving aerosol properties using TEMPO and GOES-R Advanced Baseline Imager (ABI) measurements. Because TEMPO does not have a cloud camera or needed spectral channels to identify clouds and a Shortwave IR band to characterize the surface that are essential for aerosol retrievals, GOES-R ABI can supplement those measurements. GOES-R aerosol team conducted a study to determine idealistic position of TEMPO and GOES-R (in its both east and west location) for scene overlap and projection of ABI Shortwave IR (2.25 um) reflectance and cloud mask to TEMPO pixels. The BRDF effect was taken into consideration in determining the spatial coverage of pixels ideal for aerosol retrievals using ABI shortwave IR reflectance in TEMPO pixels to extrapolate reflectance at visible spectral bands. Analysis shows that GOES-R (in its west location, 135W) and TEMPO do not overlap over eastern part of the United States (US) and Atlantic Ocean, while GOES-R (in its east location, 75W) overlaps with TEMPO over most part of the United States (US) except for small part of Pacific Ocean. In addition, retrievals in the early morning and late afternoon are not possible due to BRDF effects rendering the surface reflectance too bright. Cloud mask information from GOES-R observations in both its east and west location seems to be sufficient for TEMPO. In summary, GOES-R ABI Shortwave IR radiances and cloud mask information are adequate to be used with TEMPO measurements to retrieve aerosol optical depth product several times during the sunlit portion of the continental US.

  13. Advances in real-time millimeter-wave imaging radiometers for avionic synthetic vision

    NASA Astrophysics Data System (ADS)

    Lovberg, John A.; Chou, Ri-Chee; Martin, Christopher A.; Galliano, Joseph A., Jr.

    1995-06-01

    Millimeter-wave imaging has advantages over conventional visible or infrared imaging for many applications because millimeter-wave signals can travel through fog, snow, dust, and clouds with much less attenuation than infrared or visible light waves. Additionally, passive imaging systems avoid many problems associated with active radar imaging systems, such as radar clutter, glint, and multi-path return. ThermoTrex Corporation previously reported on its development of a passive imaging radiometer that uses an array of frequency-scanned antennas coupled to a multichannel acousto-optic spectrum analyzer (Bragg-cell) to form visible images of a scene through the acquisition of thermal blackbody radiation in the millimeter-wave spectrum. The output from the Bragg cell is imaged by a standard video camera and passed to a computer for normalization and display at real-time frame rates. An application of this system is its incorporation as part of an enhanced vision system to provide pilots with a synthetic view of a runway in fog and during other adverse weather conditions. Ongoing improvements to a 94 GHz imaging system and examples of recent images taken with this system will be presented. Additionally, the development of dielectric antennas and an electro- optic-based processor for improved system performance, and the development of an `ultra- compact' 220 GHz imaging system will be discussed.

  14. Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems.

    PubMed

    Vaquero, Juan José; Kinahan, Paul

    2015-01-01

    Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges.

  15. Advanced photoacoustic and thermoacoustic sensing and imaging beyond pulsed absorption contrast

    NASA Astrophysics Data System (ADS)

    Gao, Fei; Feng, Xiaohua; Zheng, Yuanjin

    2016-07-01

    In this paper, we review the recent progress in the photoacoustic (PA) and thermoacoustic (TA) imaging domain. Going beyond the conventional investigation of optical/microwave absorption contrast, this review will focus more on the new developments of PA and TA imaging towards multi-contrast mechanisms, such as multimodal PA/TA imaging, viscosity imaging, temperature monitoring, Doppler detection of flow speed, etc. In addition, several interesting techniques utilizing PA/TA will be reviewed, including photoacoustic-guided optical focusing, electrical circuit modeling of PA/TA effect, TA imaging with coherent continuous-wave (CW) magnetic and radio-frequency (RF) excitations, as well as its nonlinear effect. Finally, some prospects about the further improvement of PA/TA imaging techniques are suggested, followed by the conclusion.

  16. Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems.

    PubMed

    Vaquero, Juan José; Kinahan, Paul

    2015-01-01

    Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been widely adopted as an important clinical modality for oncological, cardiovascular, and neurological applications. PET imaging has also become an important tool in preclinical studies, particularly for investigating murine models of disease and other small-animal models. However, there are several challenges to using PET imaging systems. These include the fundamental trade-offs between resolution and noise, the quantitative accuracy of the measurements, and integration with X-ray computed tomography and magnetic resonance imaging. In this article, we review how researchers and industry are addressing these challenges. PMID:26643024

  17. Advances in 4D radiation therapy for managing respiration: part I - 4D imaging.

    PubMed

    Hugo, Geoffrey D; Rosu, Mihaela

    2012-12-01

    Techniques for managing respiration during imaging and planning of radiation therapy are reviewed, concentrating on free-breathing (4D) approaches. First, we focus on detailing the historical development and basic operational principles of currently-available "first generation" 4D imaging modalities: 4D computed tomography, 4D cone beam computed tomography, 4D magnetic resonance imaging, and 4D positron emission tomography. Features and limitations of these first generation systems are described, including necessity of breathing surrogates for 4D image reconstruction, assumptions made in acquisition and reconstruction about the breathing pattern, and commonly-observed artifacts. Both established and developmental methods to deal with these limitations are detailed. Finally, strategies to construct 4D targets and images and, alternatively, to compress 4D information into static targets and images for radiation therapy planning are described.

  18. Advances in 4D Radiation Therapy for Managing Respiration: Part I – 4D Imaging

    PubMed Central

    Hugo, Geoffrey D.; Rosu, Mihaela

    2014-01-01

    Techniques for managing respiration during imaging and planning of radiation therapy are reviewed, concentrating on free-breathing (4D) approaches. First, we focus on detailing the historical development and basic operational principles of currently-available “first generation” 4D imaging modalities: 4D computed tomography, 4D cone beam computed tomography, 4D magnetic resonance imaging, and 4D positron emission tomography. Features and limitations of these first generation systems are described, including necessity of breathing surrogates for 4D image reconstruction, assumptions made in acquisition and reconstruction about the breathing pattern, and commonly-observed artifacts. Both established and developmental methods to deal with these limitations are detailed. Finally, strategies to construct 4D targets and images and, alternatively, to compress 4D information into static targets and images for radiation therapy planning are described. PMID:22784929

  19. Advanced 2D-3D registration for endovascular aortic interventions: addressing dissimilarity in images

    NASA Astrophysics Data System (ADS)

    Demirci, Stefanie; Kutter, Oliver; Manstad-Hulaas, Frode; Bauernschmitt, Robert; Navab, Nassir

    2008-03-01

    In the current clinical workflow of minimally invasive aortic procedures navigation tasks are performed under 2D or 3D angiographic imaging. Many solutions for navigation enhancement suggest an integration of the preoperatively acquired computed tomography angiography (CTA) in order to provide the physician with more image information and reduce contrast injection and radiation exposure. This requires exact registration algorithms that align the CTA volume to the intraoperative 2D or 3D images. Additional to the real-time constraint, the registration accuracy should be independent of image dissimilarities due to varying presence of medical instruments and contrast agent. In this paper, we propose efficient solutions for image-based 2D-3D and 3D-3D registration that reduce the dissimilarities by image preprocessing, e.g. implicit detection and segmentation, and adaptive weights introduced into the registration procedure. Experiments and evaluations are conducted on real patient data.

  20. Advanced Cellular and Biomolecular Imaging at Lehigh University, (PA) Final Scientific/Technical Report

    SciTech Connect

    Cassimeris, Lynne, U.

    2010-09-10

    Lehigh University is establishing an interdisciplinary program in high resolution cellular and subcellular biological imaging for a range of applications including improved cancer detection. The completed DOE project added to Lehigh?s bio-imaging infrastructure through acquisition of a new confocal microscope system as well as upgrades to two pieces of existing equipment. Bio-imaging related research at Lehigh was also supported through two seed grants for initiation of new projects.

  1. Passive and Active Fast-Neutron Imaging in Support of Advanced Fuel Cycle Initiative Safeguards Campaign

    SciTech Connect

    Blackston, Matthew A; Hausladen, Paul

    2010-04-01

    Results from safeguards-related passive and active coded-aperture fast-neutron imaging measurements of plutonium and highly enriched uranium (HEU) material configurations performed at Idaho National Laboratory s Zero Power Physics Reactor facility are presented. The imaging measurements indicate that it is feasible to use fast neutron imaging in a variety of safeguards-related tasks, such as monitoring storage, evaluating holdup deposits in situ, or identifying individual leached hulls still containing fuel. The present work also presents the first demonstration of imaging of differential die away fast neutrons.

  2. Pediatric Cerebellar Tumors: Emerging Imaging Techniques and Advances in Understanding of Genetic Features.

    PubMed

    Choudhri, Asim F; Siddiqui, Adeel; Klimo, Paul

    2016-08-01

    Cerebellar tumors are the most common group of solid tumors in children. MR imaging provides an important role in characterization of these lesions, surgical planning, and postsurgical surveillance. Preoperative imaging can help predict the histologic subtype of tumors, which can provide guidance for surgical planning. Beyond histology, pediatric brain tumors are undergoing new classification schemes based on genetic features. Intraoperative MR imaging has emerged as an important tool in the surgical management of pediatric brain tumors. Effective understanding of the imaging features of pediatric cerebellar tumors can benefit communication with neurosurgeons and neuro-oncologists and can improve patient management.

  3. Pediatric Cerebellar Tumors: Emerging Imaging Techniques and Advances in Understanding of Genetic Features.

    PubMed

    Choudhri, Asim F; Siddiqui, Adeel; Klimo, Paul

    2016-08-01

    Cerebellar tumors are the most common group of solid tumors in children. MR imaging provides an important role in characterization of these lesions, surgical planning, and postsurgical surveillance. Preoperative imaging can help predict the histologic subtype of tumors, which can provide guidance for surgical planning. Beyond histology, pediatric brain tumors are undergoing new classification schemes based on genetic features. Intraoperative MR imaging has emerged as an important tool in the surgical management of pediatric brain tumors. Effective understanding of the imaging features of pediatric cerebellar tumors can benefit communication with neurosurgeons and neuro-oncologists and can improve patient management. PMID:27423803

  4. Imaging Evidence for Hubbard Glacier Advances and Retreats since the Last Glacial Maximum in Disenchantment and Yakutat Bays, Alaska

    NASA Astrophysics Data System (ADS)

    Zurbuchen, J.; Gulick, S. P.; Levoir, M. A.; Goff, J. A.; Haeussler, P. J.

    2013-12-01

    As glaciers advance and retreat, they leave erosional surfaces, retreat sequences, morainal banks, and terminal moraines. These features can be imaged and interpreted in seismic reflection data to gain insight into ice routing, ice-sediment processes, and preserved glacial history. High-resolution 2-D multichannel seismic data gathered on the August 2012 UTIG-USGS National Earthquake Hazards Reduction Program survey of Disenchantment and Yakutat Bays have provided understanding of the advance pathways of the Hubbard Glacier and the glacial history of the bays. These data show evidence of three unconformities appearing in the form of channels and interpreted to be glacial advance and retreat paths. The youngest observable channel in Disenchantment Bay is ~2 km wide, forming morainal banks along the edges of the bay. The depth below modern sea level in two-way travel time (twtt) shallows from 510 ms in the middle of the bay to 400 ms ~4 km north of the entrance to Yakutat Bay. The sediment contained within the youngest channel measured from the seafloor thins southward from a twtt thickness of 260 ms to 115 ms. Beneath the youngest channel lies an older, 2.2 km-wide channel which is observed at ~580 ms below sea level, and is filled with sediments ranging in thickness from 480 ms to 180 ms at the terminus. This older channel extends from Disenchantment Bay into Yakutat Bay, staying to the northeast of Yakutat Bay, then turns southward at Knight Island and shallows to 450 ms twtt before forming a terminal moraine ~10 km north of the mouth of Yakutat Bay. Evidence for the third and oldest unconformity can only be seen within a very small number of short seismic lines in Disenchantment Bay. It is the largest of the channels, at ~3 km wide and 720 ms below modern sea level. The evidence of three nested unconformities suggests that the Hubbard Glacier has had at least three major advances in recent history. Radiocarbon dating of wooden branches in moraine deposits

  5. Final Report for The University of Texas at Arlington Optical Medical Imaging Section of Advanced Imaging Research Center

    SciTech Connect

    Khosrow Behbehani

    2013-02-26

    The goal of this project was to create state-of-the-art optical medical imaging laboratories for the Biomedical Engineering faculty and student researchers of the University of Texas at Arlington (UTA) on the campus of the University of Texas Southwestern Medical Center (UTSW). This has been successfully achieved. These laboratories provide an unprecedented opportunity for the bioengineers (from UTA) to bring about new breakthroughs in medical imaging using optics. Specifically, three major laboratories have been successfully established and state-of-the-art scientific instruments have been placed in the labs. As a result of this grant, numerous journal and conference publications have been generated, patents for new inventions have been filed and received, and many additional grants for the continuation of the research has been received.

  6. X-ray Diffraction and Multi-Frame Phase Contrast Imaging Diagnostics for IMPULSE at the Advanced Photon Source

    SciTech Connect

    Iverson, Adam; Carlson, Carl; Young, Jason; Curtis, Alden; Jensen, Brian; Ramos, Kyle; Yeager, John; Montgomery, David; Fezza, Kamel

    2013-07-08

    The diagnostic needs of any dynamic loading platform present unique technical challenges that must be addressed in order to accurately measure in situ material properties in an extreme environment. The IMPULSE platform (IMPact system for Ultrafast Synchrotron Experiments) at the Advanced Photon Source (APS) is no exception and, in fact, may be more challenging, as the imaging diagnostics must be synchronized to both the experiment and the 60 ps wide x-ray bunches produced at APS. The technical challenges of time-resolved x-ray diffraction imaging and high-resolution multi-frame phase contrast imaging (PCI) are described in this paper. Example data from recent IMPULSE experiments are shown to illustrate the advances and evolution of these diagnostics with a focus on comparing the performance of two intensified CCD cameras and their suitability for multi-frame PCI. The continued development of these diagnostics is fundamentally important to IMPULSE and many other loading platforms and will benefit future facilities such as the Dynamic Compression Sector at APS and MaRIE at Los Alamos National Laboratory.

  7. A Simple Arbitrary Solid Slicer

    SciTech Connect

    Yao, J

    2005-06-23

    The intersection of a given plane and an arbitrary (possibly non-convex, with multiple connectivities) meshed solid is exactly expressed by a set of planar cross-sections. A rule for marching on the edges of an arbitrary polyhedron is set for obtaining the topology of the cross-section. The method neither seeks triangulation of the surface mesh nor utilizes look-up tables, therefore it has optimal efficiency.

  8. Advances in functional X-ray imaging techniques and contrast agents

    PubMed Central

    Chen, Hongyu; Rogalski, Melissa M.

    2012-01-01

    X-rays have been used for non-invasive high-resolution imaging of thick biological specimens since their discovery in 1895. They are widely used for structural imaging of bone, metal implants, and cavities in soft tissue. Recently, a number of new contrast methodologies have emerged which are expanding X-ray’s biomedical applications to functional as well as structural imaging. These techniques are promising to dramatically improve our ability to study in situ biochemistry and disease pathology. In this review, we discuss how X-ray absorption, X-ray fluorescence, and X-ray excited optical luminescence can be used for physiological, elemental, and molecular imaging of vasculature, tumours, pharmaceutical distribution, and the surface of implants. Imaging of endogenous elements, exogenous labels, and analytes detected with optical indicators will be discussed. PMID:22962667

  9. Advances in Molecular Imaging Strategies for In Vivo Tracking of Immune Cells

    PubMed Central

    Lee, Ho Won; Gangadaran, Prakash

    2016-01-01

    Tracking of immune cells in vivo is a crucial tool for development and optimization of cell-based therapy. Techniques for tracking immune cells have been applied widely for understanding the intrinsic behavior of immune cells and include non-radiation-based techniques such as optical imaging and magnetic resonance imaging (MRI), radiation-based techniques such as computerized tomography (CT), and nuclear imaging including single photon emission computerized tomography (SPECT) and positron emission tomography (PET). Each modality has its own strengths and limitations. To overcome the limitations of each modality, multimodal imaging techniques involving two or more imaging modalities are actively applied. Multimodal techniques allow integration of the strengths of individual modalities. In this review, we discuss the strengths and limitations of currently available preclinical in vivo immune cell tracking techniques and summarize the value of immune cell tracking in the development and optimization of immune cell therapy for various diseases. PMID:27725934

  10. National Institute of Biomedical Imaging and Bioengineering Point-of-Care Technology Research Network: Advancing Precision Medicine

    PubMed Central

    Ford Carleton, Penny; Parrish, John A.; Collins, John M.; Crocker, J. Benjamin; Dixon, Ronald F.; Edgman-Levitan, Susan; Lewandrowski, Kent B.; Stahl, James E.; Klapperich, Catherine; Cabodi, Mario; Gaydos, Charlotte A.; Rompalo, Anne M.; Manabe, Yukari; Wang, Tza-Huei; Rothman, Richard; Geddes, Chris D.; Widdice, Lea; Jackman, Joany; Mathura, Rishi A.; Lash, Tiffani Bailey

    2016-01-01

    To advance the development of point-of-care technology (POCT), the National Institute of Biomedical Imaging and Bioengineering established the POCT Research Network (POCTRN), comprised of Centers that emphasize multidisciplinary partnerships and close facilitation to move technologies from an early stage of development into clinical testing and patient use. This paper describes the POCTRN and the three currently funded Centers as examples of academic-based organizations that support collaborations across disciplines, institutions, and geographic regions to successfully drive innovative solutions from concept to patient care. PMID:27730014

  11. Advances in interpretation of subsurface processes with time-lapse electrical imaging

    SciTech Connect

    Singha, Kamini; Day-Lewis, Frederick D.; Johnson, Timothy C.; Slater, Lee D.

    2015-03-15

    Electrical geophysical methods, including electrical resistivity, time-domain induced polarization, and complex resistivity, have become commonly used to image the near subsurface. Here, we outline their utility for time-lapse imaging of hydrological, geochemical, and biogeochemical processes, focusing on new instrumentation, processing, and analysis techniques specific to monitoring. We review data collection procedures, parameters measured, and petrophysical relationships and then outline the state of the science with respect to inversion methodologies, including coupled inversion. We conclude by highlighting recent research focused on innovative applications of time-lapse imaging in hydrology, biology, ecology, and geochemistry, among other areas of interest.

  12. IR and Raman imaging of murine brains from control and ApoE/LDLR(-/-) mice with advanced atherosclerosis.

    PubMed

    Kochan, Kamila; Chrabaszcz, Karolina; Szczur, Barbara; Maslak, Edyta; Dybas, Jakub; Marzec, Katarzyna M

    2016-09-21

    Confocal Raman mapping and FT-IR imaging combined with chemometric analysis was used to study the alterations in murine brain tissue induced by the development of atherosclerosis. FT-IR imaging allowed us to obtain lower spatial resolution data (∼5.5 μm) from large, representative cross-sectional brain areas, while Raman mapping provided a more detailed insight into chosen regions of interest with high spatial resolution (∼0.4 μm). A comparison of white (WM) and grey matter (GM) from control (C57BL/6J) and ApoE/LDLR(-/-) mice with advanced atherosclerosis revealed disease-induced changes in both: GM and WM. The alterations included an increased lipid to protein ratio and higher total content of cholesterol.

  13. IR and Raman imaging of murine brains from control and ApoE/LDLR(-/-) mice with advanced atherosclerosis.

    PubMed

    Kochan, Kamila; Chrabaszcz, Karolina; Szczur, Barbara; Maslak, Edyta; Dybas, Jakub; Marzec, Katarzyna M

    2016-09-21

    Confocal Raman mapping and FT-IR imaging combined with chemometric analysis was used to study the alterations in murine brain tissue induced by the development of atherosclerosis. FT-IR imaging allowed us to obtain lower spatial resolution data (∼5.5 μm) from large, representative cross-sectional brain areas, while Raman mapping provided a more detailed insight into chosen regions of interest with high spatial resolution (∼0.4 μm). A comparison of white (WM) and grey matter (GM) from control (C57BL/6J) and ApoE/LDLR(-/-) mice with advanced atherosclerosis revealed disease-induced changes in both: GM and WM. The alterations included an increased lipid to protein ratio and higher total content of cholesterol. PMID:27332112

  14. More advances in real-time millimeter-wave imaging radiometers for avionic synthetic vision

    NASA Astrophysics Data System (ADS)

    Chou, Ri-Chee; Lovberg, John A.; Martin, Christopher A.

    1997-06-01

    Millimeter-wave thermal imaging provides a unique autonomous capability for aircraft landing in adverse weather, giving a pilot a comprehensive view of runway location and availability in real time with high fidelity. ThermoTrex Corporation has reported previous results from a passive millimeter-wave camera demonstration device. The addition of W-band low-noise amplifiers into the front end of this sparse phased-array thermal imaging camera has improved system thermal sensitivity by 5 dB over that previously reported. Processing upgrades have increased system frame update rate to about 1 Hz, and remote site field testing has established phenomenology relevant to aircraft landing guidance applications. Next-generation hardware design has addressed the issue of aircraft integration using an innovative lightweight, X-band antenna for 89 GHz thermal imaging. A flightworthy demonstration imager using this antenna is currently under construction for 10 Hz operation.

  15. Advanced diagnostic imaging in privately insured patients: recent trends in utilization and payments.

    PubMed

    Horný, Michal; Burgess, James F; Horwitt, Jedediah; Cohen, Alan B

    2014-07-01

    Recent studies have reported that the rate of growth in utilization of noninvasive diagnostic imaging has slowed, with a concomitant reduction in total payments to providers in the Medicare Part B fee-for-service population. Utilization and payment growth trends in commercially insured populations, however, are not as well understood. We used the Truven Health Analytics MarketScan® Commercial Claims and Encounters database containing more than 29 million individuals to investigate commercially insured population trends in utilization of and payments for CT, MRI, PET, and ultrasound procedures in the years 2007-2011. We found that imaging use--after a brief downturn in 2010--rose again in 2011, coupled with substantial increases in adjusted payments for all four imaging modalities, raising concerns about future efforts to stem growth in imaging use and associated spending.

  16. Fusion of visual and infrared thermography images for advanced assessment in non-destructive testing.

    PubMed

    Eisler, K; Homma, C; Goldammer, M; Rothenfusser, M; Arnold, W

    2013-06-01

    For better evaluation of infrared measurements in non-destructive testing, especially for objects with complex geometry or small dimensions, it is beneficial to combine with the same viewing angle an image of a camera in the visible range with the image of an infrared camera. In the hybrid camera developed by us, a beam splitter is used which combines the visible and the infrared wavelength regions under the same viewing angle to form a hybrid image. The applications of this new technique range from the localization and the verification of false indications in non-destructive testing applications to the retrieval of 3D surface information with a hybrid picture as texture with defect indications and the filtering of laser markings displayed in the IR image to area and process monitoring. PMID:23822367

  17. COxSwAIN: Compressive Sensing for Advanced Imaging and Navigation

    NASA Technical Reports Server (NTRS)

    Kurwitz, Richard; Pulley, Marina; LaFerney, Nathan; Munoz, Carlos

    2015-01-01

    The COxSwAIN project focuses on building an image and video compression scheme that can be implemented in a small or low-power satellite. To do this, we used Compressive Sensing, where the compression is performed by matrix multiplications on the satellite and reconstructed on the ground. Our paper explains our methodology and demonstrates the results of the scheme, being able to achieve high quality image compression that is robust to noise and corruption.

  18. Recent advances in photorefractivity of poly(4-diphenylaminostyrene) composites: Wavelength dependence and dynamic holographic images

    NASA Astrophysics Data System (ADS)

    Tsujimura, Sho; Kinashi, Kenji; Sakai, Wataru; Tsutsumi, Naoto

    2014-08-01

    To expand upon our previous report [Appl. Phys. Express 5, 064101 (2012) 064101], we provide here the modified poly(4-diphenylaminostyrene) (PDAS)-based photorefractive (PR) device on the basis of wavelength dependency, and demonstrate dynamic holographic images by using the PDAS-based PR device under the obtained appropriate conditions. The PR devices containing the triphenylamine unit have potential application to dynamic holographic images, which will be useful for real-time holographic displays.

  19. An advanced total variation model in H-1 space for image inpainting

    NASA Astrophysics Data System (ADS)

    Liu, Lin; Cheng, Dansong; Wang, Jun; Tian, Feng; Sun, Qiaoyu; Shi, Daming

    2015-12-01

    Image inpainting is to restore a damaged image with missing information - a fundamental problem and a hot research area in image processing. Many approaches, both geometry oriented and texture oriented, have been proposed on inpainting such as total variation (TV), Criminisi algorithm, etc. However, these approaches suffer from either limitations such as only suitable for small areas (cracks), staircase effect (discontinuity), or inefficient (time-consuming) to search the best matched patch (for filling-in). In this paper we propose a novel approach based on partial differential equation (PDE) and isophotes direction, named as Isophotes-TV-H-1. A corrupted image is first decomposed into two parts: the cartoon (smooth parts and edges of the image) and the texture. The cartoon part is inpainted through Isophotes- TV-H-1 while the texture part is done by an enhanced Criminisi algorithm which reduces the searching time for match and gives more reasonable match patches. The results of experiments on several images have demonstrated that, compared to existing methods, the proposed solution can recover the texture (of the damaged region) better, suppress error propagation and solve the problem of intensity discontinuity.

  20. Target Definition in Salvage Radiotherapy for Recurrent Prostate Cancer: The Role of Advanced Molecular Imaging

    PubMed Central

    Amzalag, Gaël; Rager, Olivier; Tabouret-Viaud, Claire; Wissmeyer, Michael; Sfakianaki, Electra; de Perrot, Thomas; Ratib, Osman; Miralbell, Raymond; Giovacchini, Giampiero; Garibotto, Valentina; Zilli, Thomas

    2016-01-01

    Salvage radiotherapy (SRT) represents the main treatment option for relapsing prostate cancer in patients after radical prostatectomy. Several open questions remain unanswered in terms of target volumes definition and delivered doses for SRT: the effective dose necessary to achieve biochemical control in the SRT setting may be different if the tumor recurrence is micro- or macroscopic. At the same time, irradiation of only the prostatic bed or of the whole pelvis will depend on the localization of the recurrence, local or locoregional. In the “theragnostic imaging” era, molecular imaging using positron emission tomography (PET) constitutes a useful tool for clinicians to define the site of the recurrence, the extent of disease, and individualize salvage treatments. The best option currently available in clinical routine is the combination of radiolabeled choline PET imaging and multiparametric magnetic resonance imaging (MRI), associating the nodal and distant metastases identification based on PET with the local assessment by MRI. A new generation of targeted tracers, namely, prostate-specific membrane antigen, show promising results, with a contrast superior to choline imaging and a higher detection rate even for low prostate-specific antigen levels; validation studies are ongoing. Finally, imaging targeting bone remodeling, using whole-body SPECT–CT, is a relevant complement to molecular/metabolic PET imaging when bone involvement is suspected. PMID:27065024

  1. ADVANCES IN IMAGING TECHNOLOGIES IN THE EVALUATION OF HIGH-GRADE BLADDER CANCER

    PubMed Central

    Zlatev, Dimitar V.; Altobelli, Emanuela; Liao, Joseph C.

    2015-01-01

    Bladder cancer is a heterogeneous disease that ranges from low-grade variant with an indolent course, to high-grade subtype with a recurrent, progressive, and potentially lethal outcome. Accurate assessment for individualized treatment depends critically on the diagnostic accuracy of white light cystoscopy. Despite its central role, white light cystoscopy has several well-documented shortcomings including difficult flat lesion detection, imprecise tumor delineation that limits complete resection, differentiation between inflammation and malignancy, and grade and stage determination. As the limitations of white light cystoscopy contribute to the risk of cancer persistence, recurrence, and progression, there is a need for improved visualization of flat, multifocal, high-grade, and muscle-invasive lesions. Optical imaging technologies have emerged as an adjunct to white light cystoscopy with the goal to guide more effective treatment by improving cancer detection and patient stratification on the basis of grade and stage. Photodynamic diagnosis and narrow band imaging are macroscopic imaging modalities similar to white light cystoscopy, but provide additional contrast enhancement of bladder tumors and have been shown to improve detection rates. Confocal laser endomicroscopy and optical coherence tomography are microscopic imaging technologies that enable real-time high resolution, subsurface tissue characterization with spatial resolutions similar to histology. Molecular imaging offers the potential for the combination of optical imaging technologies with cancer-specific molecular agents to improve the specificity of disease detection. PMID:25882557

  2. Advances in biomedical imaging using THz technology with applications to burn-wound assessment

    NASA Astrophysics Data System (ADS)

    Tewari, Priyamvada; Kealey, Colin; Sung, Jun; Maccabi, Ashkan; Bajwa, Neha; Singh, Rahul; Culjat, Martin; Stojadinovic, Alexander; Grundfest, Warren; Taylor, Zachary D.

    2012-02-01

    Terahertz (THz) hydration sensing and image has been a topic of increased interest recently due largely to improvements in source and detector technology and the identification of applications where current hydration sensing techniques are insufficient. THz medical imaging is an expanding field of research and tissue hydration plays a key role in the contrast observed in THz tissue reflectance and absorbance maps. This paper outlines the most recent results in burn and corneal imaging where hydration maps were used to assess tissue status. A 3 day study was carried out in rat models where a THz imaging system was used to assess the severity and extent of burn throughout the first day of injury and at the 24, 48, and 72 hour time points. Marked difference in tissue reflectance were observed between the partial and full thickness burns and image features were identified that may be used as diagnostic markers for burn severity. Companion histological analysis performed on tissue excised on Day 3 confirms hypothesized burn severity. The results of these preliminary animal trials suggest that THz imaging may be useful in burn wound assessment where current clinical modalities have resolution and/or sensitivity insufficient for accurate diagnostics.

  3. Real-world treatment practice in patients with advanced melanoma in the era before ipilimumab: results from the IMAGE study.

    PubMed

    Middleton, Mark R; Dalle, Stéphane; Claveau, Joel; Mut, Pilar; Hallmeyer, Sigrun; Plantin, Patrice; Highley, Martin; Kotapati, Srividya; Le, Trong Kim; Brokaw, Jane; Abernethy, Amy P

    2016-07-01

    The therapeutic landscape for advanced melanoma has recently been transformed by several novel agents (immune checkpoint inhibitors and molecular-targeted agents). The prospective, multi-site, observational study IMAGE (ipilimumab: management of advanced melanoma in real practice) included a retrospective cohort to describe real-world treatment prior to approval of the immune checkpoint inhibitor ipilimumab. This retrospective cohort of patients, who started second-line/subsequent treatment (index therapy) for advanced melanoma within 3 years before ipilimumab approval, was selected randomly by chart review. Collected data included treatment history, patient outcomes, and healthcare resource utilization. All patients had ≥1 year of follow-up data. This analysis included 177 patients from Europe (69%) and North America (31%). The most common index therapies (used alone or in combination) were fotemustine (23%), dacarbazine (21%), temozolomide (14%), and platinum-based chemotherapy (14%). Most patients (89%) discontinued index treatment during the study period; the most common reason was disease progression (59%). Among patients with tumor assessment (153/177; 86%), 2% had complete response, 5% had partial response, and 12% had stable disease on last tumor assessment. At 1-year study follow-up, median progression-free survival was 2.6 months (95% confidence interval [CI], 2.1-2.9) and median overall survival was 8.8 months (95% CI, 6.5-9.7). During follow-up, 95% of the patients had healthcare visits for advanced melanoma, 74% of whom were hospitalized or admitted to a hospice facility. These results provide insights into patient care with advanced melanoma in the era before ipilimumab and may serve as a benchmark for new agents in future real-world studies.

  4. Real-world treatment practice in patients with advanced melanoma in the era before ipilimumab: results from the IMAGE study.

    PubMed

    Middleton, Mark R; Dalle, Stéphane; Claveau, Joel; Mut, Pilar; Hallmeyer, Sigrun; Plantin, Patrice; Highley, Martin; Kotapati, Srividya; Le, Trong Kim; Brokaw, Jane; Abernethy, Amy P

    2016-07-01

    The therapeutic landscape for advanced melanoma has recently been transformed by several novel agents (immune checkpoint inhibitors and molecular-targeted agents). The prospective, multi-site, observational study IMAGE (ipilimumab: management of advanced melanoma in real practice) included a retrospective cohort to describe real-world treatment prior to approval of the immune checkpoint inhibitor ipilimumab. This retrospective cohort of patients, who started second-line/subsequent treatment (index therapy) for advanced melanoma within 3 years before ipilimumab approval, was selected randomly by chart review. Collected data included treatment history, patient outcomes, and healthcare resource utilization. All patients had ≥1 year of follow-up data. This analysis included 177 patients from Europe (69%) and North America (31%). The most common index therapies (used alone or in combination) were fotemustine (23%), dacarbazine (21%), temozolomide (14%), and platinum-based chemotherapy (14%). Most patients (89%) discontinued index treatment during the study period; the most common reason was disease progression (59%). Among patients with tumor assessment (153/177; 86%), 2% had complete response, 5% had partial response, and 12% had stable disease on last tumor assessment. At 1-year study follow-up, median progression-free survival was 2.6 months (95% confidence interval [CI], 2.1-2.9) and median overall survival was 8.8 months (95% CI, 6.5-9.7). During follow-up, 95% of the patients had healthcare visits for advanced melanoma, 74% of whom were hospitalized or admitted to a hospice facility. These results provide insights into patient care with advanced melanoma in the era before ipilimumab and may serve as a benchmark for new agents in future real-world studies. PMID:27118102

  5. Advanced Magnetic Resonance Imaging techniques to probe muscle structure and function

    NASA Astrophysics Data System (ADS)

    Malis, Vadim

    Structural and functional Magnetic Resonance Imaging (MRI) studies of skeletal muscle allow the elucidation of muscle physiology under normal and pathological conditions. Continuing on the efforts of the Muscle Imaging and Modeling laboratory, the focus of the thesis is to (i) extend and refine two challenging imaging modalities: structural imaging using Diffusion Tensor Imaging (DTI) and functional imaging based on Velocity Encoded Phase Contrast Imaging (VE-PC) and (ii) apply these methods to explore age related structure and functional differences of the gastrocnemius muscle. Diffusion Tensor Imaging allows the study of tissue microstructure as well as muscle fiber architecture. The images, based on an ultrafast single shot Echo Planar Imaging (EPI) sequence, suffer from geometric distortions and low signal to noise ratio. A processing pipeline was developed to correct for distortions and to improve image Signal to Noise Ratio (SNR). DTI acquired on a senior and young cohort of subjects were processed through the pipeline and differences in DTI derived indices and fiber architecture between the two cohorts were explored. The DTI indices indicated that at the microstructural level, fiber atrophy was accompanied with a reduction in fiber volume fraction. At the fiber architecture level, fiber length and pennation angles decreased with age that potentially contribute to the loss of muscle force with age. Velocity Encoded Phase Contrast imaging provides tissue (e.g. muscle) velocity at each voxel which allows the study of strain and Strain Rate (SR) under dynamic conditions. The focus of the thesis was to extract 2D strain rate tensor maps from the velocity images and apply the method to study age related differences. The tensor mapping can potentially provide unique information on the extracellular matrix and lateral transmission the role of these two elements has recently emerged as important determinants of force loss with age. In the cross sectional study on

  6. Comparing Hyperion Lunar Observation with model calculations in support of GOES-R Advanced Baseline Imager (ABI) calibration

    NASA Astrophysics Data System (ADS)

    Shao, Xi; Cao, Changyong; Uprety, Sirish; Padula, Frank; Choi, Taeyoung

    2014-09-01

    Radiometric stability of the lunar surface and its smooth reflectance spectrum makes the moon an attractive candidate for calibrating satellite-based hyper/multi-band visible and infrared imagers. Long-term performance monitoring of satellite instrument using Moon can reveal the degradation of instruments. In this paper, analysis of Hyperion lunar observations and comparison with lunar model are performed in support of Cal/Val activities for satellite photometric imager such as GOES-R Advanced Baseline Imager (ABI) instrument. Hyperion makes hyper-spectral observations of the moon regularly with moon phase mostly at 7 degree and it covers visible and shirt-wavelength infrared (SWIR) channels with 10 nm spectral resolution. Five Hyperion lunar observations are analyzed. Lunar reflectance is derived from Hyperion observation and the mean absolute lunar spectral reflectance difference between Hyperion derivation and lunar model is 4.0 ± 2.62%. Through reflectance comparison, over-compensation of two strong atmospheric water absorption bands in Hyperion calibration is identified. The radiometric variance and degradation of Hyperion are assessed. To support the calibration of GOES-R ABI, hyper-spectral data of Hyperion lunar observation is convoluted with ABI spectral response functions for reflective solar bands to synthesize predicted lunar images to be observed by ABI. Lunar irradiances are derived from these synthesized lunar images for ABI and compared with lunar model predictions to quantify spectral biases. Long-term lunar imaging window of opportunities for GOES-R ABI are also assessed. The ability of using lunar model and Hyperion observation to calibrate satellite VNIR/SWIR sensors and reduce the measurement uncertainties is essential to support post-launch Cal/Val activities of GOES-R ABI.

  7. Comparison of Landsat-7 Enhanced Thematic Mapper Plus (ETM+) and Earth Observing One (EO-1) Advanced Land Imager

    NASA Technical Reports Server (NTRS)

    Pedelty, Jeffrey A.; Morisette, Jeffrey T.; Smith, James A.

    2004-01-01

    We compare images from the Enhanced Thematic Mapper Plus (ETM+) sensor on Landsat-7 and the Advanced Land Imager (ALI) instrument on Earth Observing One (EO-1) over a test site in Rochester, New York. The site contains a variety of features, ranging from water of varying depths, deciduous/coniferous forest, and grass fields, to urban areas. Nearly coincident cloud-free images were collected one minute apart on 25 August 2001. We also compare images of a forest site near Howland, Maine, that were collected on 7 September, 2001. We atmospherically corrected each pair of images with the Second Simulation of the Satellite Signal in the Solar Spectrum (6S) atmosphere model, using aerosol optical thickness and water vapor column density measured by in situ Cimel sun photometers within the Aerosol Robotic Network (AERONET), along with ozone density derived from the Total Ozone Mapping Spectrometer (TOMS) on the Earth Probe satellite. We present true-color composites from each instrument that show excellent qualitative agreement between the multispectral sensors, along with grey-scale images that demonstrate a significantly improved ALI panchromatic band. We quantitatively compare ALI and ETM+ reflectance spectra of a grassy field in Rochester and find < or equal to 6% differences in the visible/near infrared and approx. 2% differences in the short wave infrared. Spectral comparisons of forest sites in Rochester and Howland yield similar percentage agreement except for band 1, which has very low reflectance. Principal component analyses and comparison of normalized difference vegetation index histograms for each sensor indicate that the ALI is able to reproduce the information content in the ETM+ but with superior signal-to-noise performance due to its increased 12-bit quantization.

  8. Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research.

    PubMed

    Anderson, Carolyn J; Ferdani, Riccardo

    2009-08-01

    Copper-64 (T(1/2) = 12.7 hours; beta(+), 0.653 MeV [17.8 %]; beta(-), 0.579 MeV [38.4 %]) has decay characteristics that allow for positron emission tomography (PET) imaging and targeted radiotherapy of cancer. The well-established coordination chemistry of copper allows for its reaction with a wide variety of chelator systems that can potentially be linked to peptides and other biologically relevant small molecules, antibodies, proteins, and nanoparticles. The 12.7-hours half-life of 64Cu provides the flexibility to image both smaller molecules and larger, slower clearing proteins and nanoparticles. In a practical sense, the radionuclide or the 64Cu-radiopharmaceuticals can be easily shipped for PET imaging studies at sites remote to the production facility. Due to the versatility of 64Cu, there has been an abundance of novel research in this area over the past 20 years, primarily in the area of PET imaging, but also for the targeted radiotherapy of cancer. The biologic activity of the hypoxia imaging agent, 60/64Cu-ATSM, has been described in great detail in animal models and in clinical PET studies. An investigational new drug application for 64Cu-ATSM was recently approved by the U.S. Food and Drug Administration (FDA) in the United States, paving the way for a multicenter trial to validate the utility of this agent, with the hopeful result being FDA approval for routine clinical use. This article discusses state-of-the-art cancer imaging with 64Cu radiopharmaceuticals, including 64Cu-ATSM for imaging hypoxia, 64Cu-labeled peptides for tumor-receptor targeting, (64)Cu-labeled monoclonal antibodies for targeting tumor antigens, and 64Cu-labeled nanoparticles for cancer targeting. The emphasis of this article will be on the new scientific discoveries involving (64)Cu radiopharmaceuticals, as well as the translation of these into human studies.

  9. Enhanced ultrasound for advanced diagnostics, ultrasound tomography for volume limb imaging and prosthetic fitting

    NASA Astrophysics Data System (ADS)

    Anthony, Brian W.

    2016-04-01

    Ultrasound imaging methods hold the potential to deliver low-cost, high-resolution, operator-independent and nonionizing imaging systems - such systems couple appropriate algorithms with imaging devices and techniques. The increasing demands on general practitioners motivate us to develop more usable and productive diagnostic imaging equipment. Ultrasound, specifically freehand ultrasound, is a low cost and safe medical imaging technique. It doesn't expose a patient to ionizing radiation. Its safety and versatility make it very well suited for the increasing demands on general practitioners, or for providing improved medical care in rural regions or the developing world. However it typically suffers from sonographer variability; we will discuss techniques to address user variability. We also discuss our work to combine cylindrical scanning systems with state of the art inversion algorithms to deliver ultrasound systems for imaging and quantifying limbs in 3-D in vivo. Such systems have the potential to track the progression of limb health at a low cost and without radiation exposure, as well as, improve prosthetic socket fitting. Current methods of prosthetic socket fabrication remain subjective and ineffective at creating an interface to the human body that is both comfortable and functional. Though there has been recent success using methods like magnetic resonance imaging and biomechanical modeling, a low-cost, streamlined, and quantitative process for prosthetic cup design and fabrication has not been fully demonstrated. Medical ultrasonography may inform the design process of prosthetic sockets in a more objective manner. This keynote talk presents the results of progress in this area.

  10. GOES-R Advanced Baseline Imager: spectral response functions and radiometric biases with the NPP Visible Infrared Imaging Radiometer Suite evaluated for desert calibration sites.

    PubMed

    Pearlman, Aaron; Pogorzala, David; Cao, Changyong

    2013-11-01

    The Advanced Baseline Imager (ABI), which will be launched in late 2015 on the National Oceanic and Atmospheric Administration's Geostationary Operational Environmental Satellite R-series satellite, will be evaluated in terms of its data quality postlaunch through comparisons with other satellite sensors such as the recently launched Visible Infrared Imaging Radiometer Suite (VIIRS) aboard the Suomi National Polar-orbiting Partnership satellite. The ABI has completed much of its prelaunch characterization and its developers have generated and released its channel spectral response functions (response versus wavelength). Using these responses and constraining a radiative transfer model with ground reflectance, aerosol, and water vapor measurements, we simulate observed top of atmosphere (TOA) reflectances for analogous visible and near infrared channels of the VIIRS and ABI sensors at the Sonoran Desert and White Sands National Monument sites and calculate the radiometric biases and their uncertainties. We also calculate sensor TOA reflectances using aircraft hyperspectral data from the Airborne Visible/Infrared Imaging Spectrometer to validate the uncertainties in several of the ABI and VIIRS channels and discuss the potential for validating the others. Once on-orbit, calibration scientists can use these biases to ensure ABI data quality and consistency to support the numerical weather prediction community and other data users. They can also use the results for ABI or VIIRS anomaly detection and resolution.

  11. Advancing Biomedical Image Retrieval: Development and Analysis of a Test Collection

    PubMed Central

    Hersh, William R.; Müller, Henning; Jensen, Jeffery R.; Yang, Jianji; Gorman, Paul N.; Ruch, Patrick

    2006-01-01

    Objective Develop and analyze results from an image retrieval test collection. Methods After participating research groups obtained and assessed results from their systems in the image retrieval task of Cross-Language Evaluation Forum, we assessed the results for common themes and trends. In addition to overall performance, results were analyzed on the basis of topic categories (those most amenable to visual, textual, or mixed approaches) and run categories (those employing queries entered by automated or manual means as well as those using visual, textual, or mixed indexing and retrieval methods). We also assessed results on the different topics and compared the impact of duplicate relevance judgments. Results A total of 13 research groups participated. Analysis was limited to the best run submitted by each group in each run category. The best results were obtained by systems that combined visual and textual methods. There was substantial variation in performance across topics. Systems employing textual methods were more resilient to visually oriented topics than those using visual methods were to textually oriented topics. The primary performance measure of mean average precision (MAP) was not necessarily associated with other measures, including those possibly more pertinent to real users, such as precision at 10 or 30 images. Conclusions We developed a test collection amenable to assessing visual and textual methods for image retrieval. Future work must focus on how varying topic and run types affect retrieval performance. Users' studies also are necessary to determine the best measures for evaluating the efficacy of image retrieval systems. PMID:16799124

  12. Recent advances in near-infrared fluorescence-guided imaging surgery using indocyanine green.

    PubMed

    Namikawa, Tsutomu; Sato, Takayuki; Hanazaki, Kazuhiro

    2015-12-01

    Near-infrared (NIR) fluorescence imaging has better tissue penetration, allowing for the effective rejection of excitation light and detection deep inside organs. Indocyanine green (ICG) generates NIR fluorescence after illumination by an NIR ray, enabling real-time intraoperative visualization of superficial lymphatic channels and vessels transcutaneously. The HyperEye Medical System (HEMS) can simultaneously detect NIR rays under room light to provide color imaging, which enables visualization under bright light. Thus, NIR fluorescence imaging using ICG can provide for excellent diagnostic accuracy in detecting sentinel lymph nodes in cancer and microvascular circulation in various ischemic diseases, to assist us with intraoperative decision making. Including HEMS in this system could further improve the sentinel lymph node mapping and intraoperative identification of blood supply in reconstructive organs and ischemic diseases, making it more attractive than conventional imaging. Moreover, the development of new laparoscopic imaging systems equipped with NIR will allow fluorescence-guided surgery in a minimally invasive setting. Future directions, including the conjugation of NIR fluorophores to target specific cancer markers might be realistic technology with diagnostic and therapeutic benefits.

  13. Oversampling advances in millimeter-wave scan imaging using inexpensive neon indicator lamp detectors

    NASA Astrophysics Data System (ADS)

    Levanon, Assaf; Kopeika, Natan S.; Yitzhaky, Yitzhak; Abramovich, Amir; Rozban, Daniel; Joseph, Hezi; Aharon, Avihai; Belenky, Alex; Gefen, Michael; Yadid-Pecht, Orly

    2013-06-01

    In recent years, much effort has been invested to develop room temperature inexpensive, but sensitive, millimeter wave (MMW) and terahertz (THz) detectors that can be used as pixels in focal plane arrays, which is important for real-time imaging. A new 18×2 neon indicator lamp MMW/THz scanner was developed. The components of the camera include horizontally shifted two-column glow discharge detectors in a scanning array. The detectors, costing about 50 cents each, are wired to a preprocessing card, a VLSI board, and a motor for scanner movement. A description of the VLSI Verilog programmable hardware of the new scanner, the physical architecture, the software user interface, and imaging results at 97 GHz are presented. At this stage, the emphasis is focused on the lamp exposure time and spatial resolution when the scanning is performed horizontally. In the future it is planned to expose all pixels simultaneously for real-time imaging. New software capabilities allow the application of digital image enhancement algorithms. Fast scanning permits obtaining images in 1 to 5 s. Oversampling yields a sharper edge response and a higher signal-to-noise ratio.

  14. Advancing the Use of Administrative Data for Emergency Department Diagnostic Imaging Research.

    PubMed

    Kuehl, Damon R; Berdahl, Carl T; Jackson, Tiffany D; Venkatesh, Arjun K; Mistry, Rakesh D; Bhargavan-Chatfield, Mythreyi; Raukar, Neha P; Carr, Brendan G; Schuur, Jeremiah D; Kocher, Keith E

    2015-12-01

    Administrative data are critical to describing patterns of use, cost, and appropriateness of imaging in emergency care. These data encompass a range of source materials that have been collected primarily for a nonresearch use: documenting clinical care (e.g., medical records), administering care (e.g., picture archiving and communication systems), or financial transactions (e.g., insurance claims). These data have served as the foundation for large, descriptive studies that have documented the rise and expanded role of diagnostic imaging in the emergency department (ED). This article summarizes the discussions of the breakout session on the use of administrative data for emergency imaging research at the May 2015 Academic Emergency Medicine consensus conference, "Diagnostic Imaging in the Emergency Department: A Research Agenda to Optimize Utilization." The authors describe the areas where administrative data have been applied to research evaluating the use of diagnostic imaging in the ED, the common sources for these data, and the strengths and limitations of administrative data. Next, the future role of administrative data is examined for answering key research questions in an evolving health system increasingly focused on measuring appropriateness, ensuring quality, and improving value for health spending. This article specifically focuses on four thematic areas: data quality, appropriateness and value, special populations, and policy interventions.

  15. Imaging of Small Animal Peripheral Artery Disease Models: Recent Advancements and Translational Potential

    PubMed Central

    Lin, Jenny B.; Phillips, Evan H.; Riggins, Ti’Air E.; Sangha, Gurneet S.; Chakraborty, Sreyashi; Lee, Janice Y.; Lycke, Roy J.; Hernandez, Clarissa L.; Soepriatna, Arvin H.; Thorne, Bradford R. H.; Yrineo, Alexa A.; Goergen, Craig J.

    2015-01-01

    Peripheral artery disease (PAD) is a broad disorder encompassing multiple forms of arterial disease outside of the heart. As such, PAD development is a multifactorial process with a variety of manifestations. For example, aneurysms are pathological expansions of an artery that can lead to rupture, while ischemic atherosclerosis reduces blood flow, increasing the risk of claudication, poor wound healing, limb amputation, and stroke. Current PAD treatment is often ineffective or associated with serious risks, largely because these disorders are commonly undiagnosed or misdiagnosed. Active areas of research are focused on detecting and characterizing deleterious arterial changes at early stages using non-invasive imaging strategies, such as ultrasound, as well as emerging technologies like photoacoustic imaging. Earlier disease detection and characterization could improve interventional strategies, leading to better prognosis in PAD patients. While rodents are being used to investigate PAD pathophysiology, imaging of these animal models has been underutilized. This review focuses on structural and molecular information and disease progression revealed by recent imaging efforts of aortic, cerebral, and peripheral vascular disease models in mice, rats, and rabbits. Effective translation to humans involves better understanding of underlying PAD pathophysiology to develop novel therapeutics and apply non-invasive imaging techniques in the clinic. PMID:25993289

  16. Advances in electron microscopy: A qualitative view of instrumentation development for macromolecular imaging and tomography.

    PubMed

    Schröder, Rasmus R

    2015-09-01

    Macromolecular imaging and tomography of ice embedded samples has developed into a mature imaging technology, in structural biology today widely referred to simply as cryo electron microscopy.(1) While the pioneers of the technique struggled with ill-suited instruments, state-of-the-art cryo microscopes are now readily available and an increasing number of groups are producing excellent high-resolution structural data of macromolecular complexes, of cellular organelles, or the morphology of whole cells. Instrumentation developers, however, are offering yet more novel electron optical devices, such as energy filters and monochromators, aberration correctors or physical phase plates. Here we discuss how current instrumentation has already changed cryo EM, and how newly available instrumentation - often developed in other fields of electron microscopy - may further develop the use and applicability of cryo EM to the imaging of single isolated macromolecules of smaller size or molecules embedded in a crowded cellular environment.

  17. Comparison of analysis techniques for aerial image metrology on advanced photomask

    NASA Astrophysics Data System (ADS)

    Hwang, Seolchong; Woo, Sungha; Jang, Heeyeon; Lee, Youngmo; Kim, Sangpyo; Yang, Hyunjo; Schulz, Kristian; Garetto, Anthony

    2016-05-01

    The standard method for defect disposition and verification of repair success in the mask shop is through the utilization of the aerial imaging platform, AIMSTM. The CD (Critical Dimension) deviation of the defective or repaired region as well as the pattern shift can be calculated by comparing the measured aerial images of this region to that of a reference. Through this analysis it can be determined if the defect or repaired region will be printed on the wafer under the illumination conditions of the scanner. The analysis of the measured aerial images from the AIMSTM are commonly performed manually using the analysis software available on the system or with the help of an analysis software called RV (Repair Verification). Because the process is manual, it is not standardized and is subject to operator variations. This method of manual aerial image analysis is time consuming, dependent on the skill level of the operator and significantly contributes to the overall mask manufacturing process flow. AutoAnalysis (AA), the first application available for the FAVOR® platform, provides fully automated analysis of AIMSTM aerial images [1] and runs in parallel to the measurement of the aerial images. In this paper, we investigate the initial AutoAnalysis performance compared to the conventional method using RV and its application to a production environment. The evaluation is based on the defect CD of three pattern types: contact holes, dense line and spaces and peripheral structure. The defect analysis results for different patterns and illumination conditions will be correlated and challenges in transitioning to the new approach will be discussed.

  18. Advancements in Imaging Technology for Detection and Diagnosis of Palpable Breast Masses.

    PubMed

    Jaeger, Barbara M; Hong, Andrea S; Letter, Haley; Odell, Matthew C

    2016-06-01

    Breast cancer is the most commonly diagnosed cancer among women worldwide and the most common cause of cancer death in women. The most common presentation of breast cancer is the presence of a palpable mass, whether noted by the patient during breast self-examination or noted during clinical breast examination. There are a variety of imaging modalities now available for the evaluation of a palpable abnormality. A thorough understanding of the indications, risks, and benefits can help the clinician guide the patient through an appropriate, comprehensive imaging work up. PMID:27101239

  19. Advanced imaging as a novel approach to the characterization of membranes for microfiltration applications

    NASA Astrophysics Data System (ADS)

    Marroquin, Milagro

    The primary objectives of my dissertation were to design, develop and implement novel confocal microscopy imaging protocols for the characterization of membranes and highlight opportunities to obtain reliable and cutting-edge information of microfiltration membrane morphology and fouling processes. After a comprehensive introduction and review of confocal microscopy in membrane applications (Chapter 1), the first part of this dissertation (Chapter 2) details my work on membrane morphology characterization by confocal laser scanning microscopy (CLSM) and the implementation of my newly developed CLSM cross-sectional imaging protocol. Depth-of-penetration limits were identified to be approximately 24 microns and 7-8 microns for mixed cellulose ester and polyethersulfone membranes, respectively, making it impossible to image about 70% of the membrane bulk. The development and implementation of my cross-sectional CLSM method enabled the imaging of the entire membrane cross-section. Porosities of symmetric and asymmetric membranes with nominal pore sizes in the range 0.65-8.0 microns were quantified at different depths and yielded porosity values in the 50-60% range. It is my hope and expectation that the characterization strategy developed in this part of the work will enable future studies of different membrane materials and applications by confocal microscopy. After demonstrating how cross-sectional CLSM could be used to fully characterize membrane morphologies and porosities, I applied it to the characterization of fouling occurring in polyethersulfone microfiltration membranes during the processing of solutions containing proteins and polysaccharides (Chapter 3). Through CLSM imaging, it was determined where proteins and polysaccharides deposit throughout polymeric microfiltration membranes when a fluid containing these materials is filtered. CLSM enabled evaluation of the location and extent of fouling by individual components (protein: casein and polysaccharide

  20. ADvanced IMage Algebra (ADIMA): a novel method for depicting multiple sclerosis lesion heterogeneity, as demonstrated by quantitative MRI

    PubMed Central

    Tozer, Daniel J; Schmierer, Klaus; Chard, Declan T; Anderson, Valerie M; Altmann, Daniel R; Miller, David H; Wheeler-Kingshott, Claudia AM

    2013-01-01

    Background: There are modest correlations between multiple sclerosis (MS) disability and white matter lesion (WML) volumes, as measured by T2-weighted (T2w) magnetic resonance imaging (MRI) scans (T2-WML). This may partly reflect pathological heterogeneity in WMLs, which is not apparent on T2w scans. Objective: To determine if ADvanced IMage Algebra (ADIMA), a novel MRI post-processing method, can reveal WML heterogeneity from proton-density weighted (PDw) and T2w images. Methods: We obtained conventional PDw and T2w images from 10 patients with relapsing–remitting MS (RRMS) and ADIMA images were calculated from these. We classified all WML into bright (ADIMA-b) and dark (ADIMA-d) sub-regions, which were segmented. We obtained conventional T2-WML and T1-WML volumes for comparison, as well as the following quantitative magnetic resonance parameters: magnetisation transfer ratio (MTR), T1 and T2. Also, we assessed the reproducibility of the segmentation for ADIMA-b, ADIMA-d and T2-WML. Results: Our study’s ADIMA-derived volumes correlated with conventional lesion volumes (p < 0.05). ADIMA-b exhibited higher T1 and T2, and lower MTR than the T2-WML (p < 0.001). Despite the similarity in T1 values between ADIMA-b and T1-WML, these regions were only partly overlapping with each other. ADIMA-d exhibited quantitative characteristics similar to T2-WML; however, they were only partly overlapping. Mean intra- and inter-observer coefficients of variation for ADIMA-b, ADIMA-d and T2-WML volumes were all < 6 % and < 10 %, respectively. Conclusion: ADIMA enabled the simple classification of WML into two groups having different quantitative magnetic resonance properties, which can be reproducibly distinguished. PMID:23037551

  1. ATLAAS: an automatic decision tree-based learning algorithm for advanced image segmentation in positron emission tomography

    NASA Astrophysics Data System (ADS)

    Berthon, Beatrice; Marshall, Christopher; Evans, Mererid; Spezi, Emiliano

    2016-07-01

    Accurate and reliable tumour delineation on positron emission tomography (PET) is crucial for radiotherapy treatment planning. PET automatic segmentation (PET-AS) eliminates intra- and interobserver variability, but there is currently no consensus on the optimal method to use, as different algorithms appear to perform better for different types of tumours. This work aimed to develop a predictive segmentation model, trained to automatically select and apply the best PET-AS method, according to the tumour characteristics. ATLAAS, the automatic decision tree-based learning algorithm for advanced segmentation is based on supervised machine learning using decision trees. The model includes nine PET-AS methods and was trained on a 100 PET scans with known true contour. A decision tree was built for each PET-AS algorithm to predict its accuracy, quantified using the Dice similarity coefficient (DSC), according to the tumour volume, tumour peak to background SUV ratio and a regional texture metric. The performance of ATLAAS was evaluated for 85 PET scans obtained from fillable and printed subresolution sandwich phantoms. ATLAAS showed excellent accuracy across a wide range of phantom data and predicted the best or near-best segmentation algorithm in 93% of cases. ATLAAS outperformed all single PET-AS methods on fillable phantom data with a DSC of 0.881, while the DSC for H&N phantom data was 0.819. DSCs higher than 0.650 were achieved in all cases. ATLAAS is an advanced automatic image segmentation algorithm based on decision tree predictive modelling, which can be trained on images with known true contour, to predict the best PET-AS method when the true contour is unknown. ATLAAS provides robust and accurate image segmentation with potential applications to radiation oncology.

  2. ATLAAS: an automatic decision tree-based learning algorithm for advanced image segmentation in positron emission tomography.

    PubMed

    Berthon, Beatrice; Marshall, Christopher; Evans, Mererid; Spezi, Emiliano

    2016-07-01

    Accurate and reliable tumour delineation on positron emission tomography (PET) is crucial for radiotherapy treatment planning. PET automatic segmentation (PET-AS) eliminates intra- and interobserver variability, but there is currently no consensus on the optimal method to use, as different algorithms appear to perform better for different types of tumours. This work aimed to develop a predictive segmentation model, trained to automatically select and apply the best PET-AS method, according to the tumour characteristics. ATLAAS, the automatic decision tree-based learning algorithm for advanced segmentation is based on supervised machine learning using decision trees. The model includes nine PET-AS methods and was trained on a 100 PET scans with known true contour. A decision tree was built for each PET-AS algorithm to predict its accuracy, quantified using the Dice similarity coefficient (DSC), according to the tumour volume, tumour peak to background SUV ratio and a regional texture metric. The performance of ATLAAS was evaluated for 85 PET scans obtained from fillable and printed subresolution sandwich phantoms. ATLAAS showed excellent accuracy across a wide range of phantom data and predicted the best or near-best segmentation algorithm in 93% of cases. ATLAAS outperformed all single PET-AS methods on fillable phantom data with a DSC of 0.881, while the DSC for H&N phantom data was 0.819. DSCs higher than 0.650 were achieved in all cases. ATLAAS is an advanced automatic image segmentation algorithm based on decision tree predictive modelling, which can be trained on images with known true contour, to predict the best PET-AS method when the true contour is unknown. ATLAAS provides robust and accurate image segmentation with potential applications to radiation oncology. PMID:27273293

  3. Advances in a fully integrated intravascular OCT-ultrasound system for cardiovascular imaging

    NASA Astrophysics Data System (ADS)

    Jing, Joe; Li, Jiawen; Li, Xiang; Yin, Jiechen; Zhang, Jun; Hoang, Khiet; Patel, Pranav; Zhou, Qifa; Chen, Zhongping

    2012-01-01

    Intracoronary optical coherence tomography (OCT) and intravascular ultrasound (IVUS) are two popular techniques for the detection and determination of atherosclerosis. IVUS allows visualization of plaques while also providing a large penetration depth to determine plaque volume. Intracoronary OCT provides the ability to capture microscopic features associated with high risk plaque. Traditionally to utilize the benefits of both modalities, separate probes and systems had to be used one at a time to image a vessel. We present work required to create a combined OCT IVUS system capable of simultaneous imaging to detect atherosclerotic plaques. A novel integrated probe of size 0.69 mm OD featuring sequential placement of components was created to acquire co-registered images within small coronary vessels. By utilizing commercial graphics processing units (GPUs) real time visualization of acquired data is possible up to a maximum 48 frames per second per channel. In vitro studies on human coronary artery samples as well as in vivo studies in rabbits and pigs show various plaque buildups in both OCT and IVUS images which match histology results, demonstrating the capabilities of the system.

  4. Advances in computed tomography and magnetic resonance imaging of hepatocellular carcinoma

    PubMed Central

    Hennedige, Tiffany; Venkatesh, Sudhakar K

    2016-01-01

    Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Imaging is important for establishing a diagnosis of HCC and early diagnosis is imperative as several potentially curative treatments are available when HCC is small. Hepatocarcinogenesis occurs in a stepwise manner on a background of chronic liver disease or cirrhosis wherein multiple genes are altered resulting in a range of cirrhosis-associated nodules. This progression is related to increased cellularity, neovascularity and size of the nodule. An understanding of the stepwise progression may aid in early diagnosis. Dynamic and multiphase contrast-enhanced computed tomography and magnetic resonance imaging still form the cornerstone in the diagnosis of HCC. An overview of the current diagnostic standards of HCC in accordance to the more common practicing guidelines and their differences will be reviewed. Ancillary features contribute to diagnostic confidence and has been incorporated into the more recent Liver Imaging Reporting and Data System. The use of hepatocyte-specific contrast agents is increasing and gradually changing the standard of diagnosis of HCC; the most significant benefit being the lack of uptake in the hepatocyte phase in the earlier stages of HCC progression. An outline of supplementary techniques in the imaging of HCC will also be reviewed. PMID:26755871

  5. Advances in the medical imaging of multiple myeloma and related clinical significance.

    PubMed

    Zhang, Hai-Bo; Xue, Hua-Dan; Li, Shuo

    2014-12-01

    Multiple myeloma is an incurable malignancy developed in the bone marrow plasma cell system. It usually consists of focal lesions of the bone,soft tissue lesions,and diffuse bone marrow infiltration. Currently,the diagnosis and follow-up of multiple myeloma are highly dependent on various medical imaging techniques.

  6. Advances in hardware, software, and automation for 193nm aerial image measurement systems

    NASA Astrophysics Data System (ADS)

    Zibold, Axel M.; Schmid, R.; Seyfarth, A.; Waechter, M.; Harnisch, W.; Doornmalen, H. v.

    2005-05-01

    A new, second generation AIMS fab 193 system has been developed which is capable of emulating lithographic imaging of any type of reticles such as binary and phase shift masks (PSM) including resolution enhancement technologies (RET) such as optical proximity correction (OPC) or scatter bars. The system emulates the imaging process by adjustment of the lithography equivalent illumination and imaging conditions of 193nm wafer steppers including circular, annular, dipole and quadrupole type illumination modes. The AIMS fab 193 allows a rapid prediction of wafer printability of critical mask features, including dense patterns and contacts, defects or repairs by acquiring through-focus image stacks by means of a CCD camera followed by quantitative image analysis. Moreover the technology can be readily applied to directly determine the process window of a given mask under stepper imaging conditions. Since data acquisition is performed electronically, AIMS in many applications replaces the need for costly and time consuming wafer prints using a wafer stepper/ scanner followed by CD SEM resist or wafer analysis. The AIMS fab 193 second generation system is designed for 193nm lithography mask printing predictability down to the 65nm node. In addition to hardware improvements a new modular AIMS software is introduced allowing for a fully automated operation mode. Multiple pre-defined points can be visited and through-focus AIMS measurements can be executed automatically in a recipe based mode. To increase the effectiveness of the automated operation mode, the throughput of the system to locate the area of interest, and to acquire the through-focus images is increased by almost a factor of two in comparison with the first generation AIMS systems. In addition a new software plug-in concept is realised for the tools. One new feature has been successfully introduced as "Global CD Map", enabling automated investigation of global mask quality based on the local determination of

  7. The ARIA-EQ project: Advanced Rapid Imaging and Analysis for Earthquakes

    NASA Astrophysics Data System (ADS)

    Owen, S. E.; Webb, F.; Simons, M.; Rosen, P. A.; Cruz, J.; Yun, S.; Fielding, E. J.; Moore, A. W.; Hua, H.; Agram, P. S.

    2011-12-01

    ARIA-EQ is a joint JPL/Caltech coordinated effort to automate geodetic imaging capabilities for hazard response and societal benefit. Over the past decade, space-based geodetic measurements such as InSAR and GPS have provided new assessment capabilities and situational awareness on the size and location of earthquakes following seismic disasters. Geodetic imaging's unique ability to capture the surface deformation in high spatial and temporal resolution allow us to resolve the fault geometry and slip that generated the earthquake in correspondingly high spatial & temporal detail. In addition, remote sensing with radar provides change detection and damage assessment capabilities that can image even at night or through clouds. However, since these data sets are still essentially hand-crafted, they are not generated rapidly and reliably enough to be useful for informing decision-making agencies and the public following an earthquake. We are building an end-to-end prototype geodetic imaging data system that would form the foundation for an envisioned operational hazard response center integrating InSAR, GPS, seismology, and modeling to deliver actionable science and situational awareness products. The automated geodetic imaging data system prototype is being realized by developing more robust analysis algorithms that capture the technical knowledge of technologists and scientists. Once developed, these algorithms will enable both the delivery of actionable products from larger data sets with enhanced modeling and interpretation, and the development of next generation techniques. We will present our progress to date on defining requirements, development of prototype data system and demonstration data products, and example responses we have run such as generating products for 2011 M9.0 Tohoku-oki M6.3 and Christchurch earthquakes.

  8. Advanced image collection, information extraction, and change detection in support of NN-20 broad area search and analysis

    SciTech Connect

    Petrie, G.M.; Perry, E.M.; Kirkham, R.R.; Slator, D.E.

    1997-09-01

    This report describes the work performed at the Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy`s Office of Nonproliferation and National Security, Office of Research and Development (NN-20). The work supports the NN-20 Broad Area Search and Analysis, a program initiated by NN-20 to improve the detection and classification of undeclared weapons facilities. Ongoing PNNL research activities are described in three main components: image collection, information processing, and change analysis. The Multispectral Airborne Imaging System, which was developed to collect georeferenced imagery in the visible through infrared regions of the spectrum, and flown on a light aircraft platform, will supply current land use conditions. The image information extraction software (dynamic clustering and end-member extraction) uses imagery, like the multispectral data collected by the PNNL multispectral system, to efficiently generate landcover information. The advanced change detection uses a priori (benchmark) information, current landcover conditions, and user-supplied rules to rank suspect areas by probable risk of undeclared facilities or proliferation activities. These components, both separately and combined, provide important tools for improving the detection of undeclared facilities.

  9. Evaluation of antiangiogenic efficacy in advanced hepatocellular carcinoma: Biomarkers and functional imaging

    PubMed Central

    Bouattour, Mohamed; Payancé, Audrey; Wassermann, Johanna

    2015-01-01

    Many years after therapeutic wilderness, sorafenib finally showed a clinical benefit in patients with advanced hepatocellular carcinoma. After the primary general enthusiasm worldwide, some disappointments emerged particularly since no new treatment could exceed or at least match sorafenib in this setting. Without these new drugs, research focused on optimizing care of patients treated with sorafenib. One challenging research approach deals with identifying prognostic and predictive biomarkers of sorafenib in this population. The task still seems difficult; however appropriate investigations could resolve this dilemma, as observed for some malignancies where other drugs were used. PMID:26380650

  10. Advanced InSb monolithic Charge Coupled Infrared Imaging Devices (CCIRID)

    NASA Technical Reports Server (NTRS)

    Koch, T. L.; Thom, R. D.; Parrish, W. D.

    1981-01-01

    The continued development of monolithic InSb charge coupled infrared imaging devices (CCIRIDs) is discussed. The processing sequence and structural design of 20-element linear arrays are discussed. Also, results obtained from radiometric testing of the 20-element arrays using a clamped sample-and-hold output circuit are reported. The design and layout of a next-generation CCIRID chip are discussed. The major devices on this chip are a 20 by 16 time-delay-and-integration (TDI) area array and a 100-element linear imaging array. The development of a process for incorporating an ion implanted S(+) planar channel stop into the CCIRID structure and the development of a thin film transparent photogate are also addressed. The transparent photogates will increase quantum efficiency to greater than 70% across the 2.5 to 5.4 micrometer spectral region in future front-side illuminated CCIRIDs.

  11. A Topological Array Trigger for AGIS, the Advanced Gamma ray Imaging System

    SciTech Connect

    Krennrich, F.; Anderson, J.; Byrum, K.; Dawson, J.; Drake, G.; Haberichter, W.; Kreps, A.; Smith, A.; Buckley, J.; Krawczynski, H.; Imran, A.; Schroedter, M.

    2008-12-24

    Next generation ground based {gamma}-ray observatories such as AGIS{sup 1} and CTA{sup 2} are expected to cover a 1 km{sup 2} area with 50-100 imaging atmospheric Cherenkov telescopes. The stereoscopic view ol air showers using multiple view points raises the possibility to use a topological array trigger that adds substantial flexibility, new background suppression capabilities and a reduced energy threshold. In this paper we report on the concept and technical implementation of a fast topological trigger system, that makes use of real time image processing of individual camera patterns and their combination in a stereoscopic array analysis. A prototype system is currently under construction and we discuss the design and hardware of this topological array trigger system.

  12. Advances in Rock Magnetometry Enabled by Nitrogen-Vacancy Magnetic Imaging

    NASA Astrophysics Data System (ADS)

    Glenn, David; Kehayias, Pauli; Fu, Roger; Lima, Eduardo; Weiss, Benjamin; Walsworth, Ronald

    2016-05-01

    Magnetic imaging using nitrogen-vacancy (NV) centers in diamond allows qualitatively new questions to be addressed in the field of paleomagnetism. The NV-diamond magnetic microscope provides sensitive magnetic imaging with resolution of approximately 1 micron at room temperature, enabling spatially heterogenous magnetic sources in rock samples to be resolved at this scale for the first time. We describe new work using NV-based techniques to isolate magnetic grains in ancient terrestrial minerals (zircons), as well as ongoing investigations of several meteorite samples with interesting magnetic properties. Finally, we demonstrate the possibility of making spatially-resolved hysteresis measurements in-situ, providing a new tool for the characterization of magnetic grain sizes and composition at the micron scale.

  13. Advanced characterization and refinement of poly N-butyl cyanoacrylate microbubbles for ultrasound imaging.

    PubMed

    Fokong, Stanley; Siepmann, Monica; Liu, Zhe; Schmitz, Georg; Kiessling, Fabian; Gätjens, Jessica

    2011-10-01

    We aimed to develop and characterize poly n-butylcyanoacrylate (PBCA) microbubbles (MBs) with a narrow size distribution. MBs were synthesized by established emulsion polymerization techniques, size-isolated by centrifugation and functionalized for molecular imaging by coating their surface with streptavidin. The physical and acoustic properties of the parent solution, different-size isolated populations and functionalized MBs were measured and compared. As expected from negative zeta potentials at pH 7, cryo scanning electron microscopy showed no aggregates. In phantoms MBs were destructible at high mechanical indices and showed a frequency-dependent attenuation and backscattering. The MBs were stable in solution for more than 14 weeks and could be lyophilized without major damage. However, for injection, small needle diameters and high injection rates are shown to be critical because both lead to MB destruction. In summary, when being handled correctly, size-isolated PBCA MBs are promising candidates for preclinical functional and molecular ultrasound imaging.

  14. Imaging the DNA Alkylator Melphalan by CEST MRI: An Advanced Approach to Theranostics.

    PubMed

    Ngen, Ethel J; Bar-Shir, Amnon; Jablonska, Anna; Liu, Guanshu; Song, Xiaolei; Ansari, Roxana; Bulte, Jeff W M; Janowski, Miroslaw; Pearl, Monica; Walczak, Piotr; Gilad, Assaf A

    2016-09-01

    Brain tumors are among the most lethal types of tumors. Therapeutic response variability and failure in patients have been attributed to several factors, including inadequate drug delivery to tumors due to the blood-brain barrier (BBB). Consequently, drug delivery strategies are being developed for the local and targeted delivery of drugs to brain tumors. These drug delivery strategies could benefit from new approaches to monitor the delivery of drugs to tumors. Here, we evaluated the feasibility of imaging 4-[bis(2-chloroethyl)amino]-l-phenylalanine (melphalan), a clinically used DNA alkylating agent, using chemical exchange saturation transfer magnetic resonance imaging (CEST MRI), for theranostic applications. We evaluated the physicochemical parameters that affect melphalan's CEST contrast and demonstrated the feasibility of imaging the unmodified drug by saturating its exchangeable amine protons. Melphalan generated a CEST signal despite its reactivity in an aqueous milieu. The maximum CEST signal was observed at pH 6.2. This CEST contrast trend was then used to monitor therapeutic responses to melphalan in vitro. Upon cell death, the decrease in cellular pH from ∼7.4 to ∼6.4 caused an amplification of the melphalan CEST signal. This is contrary to what has been reported for other CEST contrast agents used for imaging cell death, where a decrease in the cellular pH following cell death results in a decrease in the CEST signal. Ultimately, this method could be used to noninvasively monitor melphalan delivery to brain tumors and also to validate therapeutic responses to melphalan clinically. PMID:27398883

  15. Advanced system model for 1574-nm imaging, scannerless, eye-safe laser radar

    NASA Astrophysics Data System (ADS)

    Schael, Ulrich; Rothe, Hendrik

    2002-10-01

    Laser radar based on gated viewing uses narrow laser pulses to illuminate a whole scene for direct (incoherent) detection. Due to the time of flight principle and a very fast shutter with precisely controlled delay time, only light reflected in the range R (range slice ΔR) is detected by a camera. Scattered light which reaches the shutter outside a given exposure time (gate) is suppressed. Hence, it is possible to "look" along the optical axis through changing atmospheric transmissions (rain, haze, fog, snow). For each laser pulse, the grey value image ES(x,y) of the camera is captured by a framegrabber for subsequent evaluation. Image sequences from these laser radar systems are ideally suited to recognize objects, because of the automatic contrast generation of the technology. Difficult object recognition problems, detection, target tracking, or obstacle avoidance at bad weather conditions are favorite applications. In this paper we discuss improvements in the system modelling and simulation of our laser radar system. Formerly the system performance was calculated for the whole system using the signal-to-noise ratio (SNR), leading to a general estimation of the maximum range of target detection. Changing to a pixel oriented approach, we are now able to study the system response for targets with arbitrary two and even three dimensional form. We take into account different kinds of target reflectivity and the Gaussian nature of the illuminating laser spot. Hence it is possible to simulate gray value images (range slices) and calculate range images. This will lead to a modulation transfer function for the system in future. Finally, the theoretical considerations are compared with experimental results from indoor measurements.

  16. Development of Advanced Imaging Criteria for the Endoscopic Identification of Inflammatory Polyps

    PubMed Central

    Sussman, Daniel A; Barkin, Jodie A; Martin, Aileen M; Varma, Tanya; Clarke, Jennifer; Quintero, Maria A; Barkin, Heather B; Deshpande, Amar R; Barkin, Jamie S; Abreu, Maria T

    2015-01-01

    OBJECTIVES: Inflammatory polyps (IPs) are frequently encountered at colonoscopy in inflammatory bowel disease (IBD) patients and are associated with an increased risk of colon cancer. The aim of this prospective endoscopic image review and analysis was to describe endoscopic features of IPs in IBD patients at surveillance colonoscopy and determine the ability to endoscopically discern IPs from other colon polyps using high-definition white light (WL), narrow band imaging with magnification (NBI), and chromoendoscopy (CE). METHODS: Digital images of IPs using WL, NBI, and CE were reviewed by four attending gastroenterologists using a two-round modified Delphi method. The ability to endoscopically discern IPs from other colon polyps was determined among groups of gastroenterology fellows and attendings. IPs were classified by gross appearance, contour, surface pattern, pit pattern, and appearance of surrounding mucosa in IPs, as well as accuracy of diagnosis. RESULTS: Features characteristic of IPs included a fibrinous cap, surface friability and ulceration, an appendage-like appearance, the halo sign with CE, and a clustering of a multiplicity of IPs. The overall diagnostic accuracy for IP identification was 63% for WL, 42% for NBI, and 64% for CE. High degrees of histologic inflammation significantly improved the accuracy of diagnosis of IP with WL and CE, whereas the use of NBI significantly impaired IP accuracy. CONCLUSIONS: The overall diagnostic accuracy when applying these criteria to clinical images was modest, with incremental benefit with addition of CE to WL. CE showed promise predicting IP histology in actively inflamed tissue. Institutional Review Board approval was obtained. ClinicalTrials.gov Identifier: NCT01557387. PMID:26583503

  17. The ARIA project: Advanced Rapid Imaging and Analysis for Natural Hazard Monitoring and Response

    NASA Astrophysics Data System (ADS)

    Owen, S. E.; Webb, F.; Simons, M.; Rosen, P. A.; Cruz, J.; Yun, S.; Fielding, E. J.; Moore, A. W.; Hua, H.; Agram, P.; Lundgren, P.

    2012-12-01

    ARIA is a joint JPL/Caltech coordinated effort to automate geodetic imaging capabilities for hazard response and societal benefit. Over the past decade, space-based geodetic measurements such as InSAR and GPS have provided new assessment capabilities and situational awareness on the size and location of earthquakes following seismic disasters and on volcanic eruptions following magmatic events. Geodetic imaging's unique ability to capture surface deformation in high spatial and temporal resolution allow us to resolve the fault geometry and distribution of slip associated with any given earthquake in correspondingly high spatial & temporal detail. In addition, remote sensing with radar provides change detection and damage assessment capabilities for earthquakes, floods and other disasters that can image even at night or through clouds. These data sets are still essentially hand-crafted, and thus are not generated rapidly and reliably enough for informing decision-making agencies and the public following an earthquake. We are building an end-to-end prototype geodetic imaging data system that would form the foundation for an envisioned operational hazard response center integrating InSAR, GPS, seismology, and modeling to deliver monitoring, actionable science, and situational awareness products. This prototype exploits state-of-the-art analysis algorithms from technologists and scientists, These algorithms enable the delivery of actionable products from larger data sets with enhanced modeling and interpretation, and the development of next generation techniques. We are collaborating with USGS scientists in both the earthquake and volcano science program for our initial data product infusion. We present our progress to date on development of prototype data system and demonstration data products, and example responses we have run such as generating products for the 2011 M9.0 Tohoku-oki, M6.3 Christchurch earthquakes, the 2011 M7.1 Van earthquake, and several simulated

  18. Advanced Mass Calibration and Visualization for FT-ICR Mass Spectrometry Imaging

    SciTech Connect

    Smith, Donald F.; Kharchenko, Andriy; Konijnenburg, Marco; Klinkert, Ivo; Pasa-Tolic, Ljiljana; Heeren, Ronald M.

    2012-11-01

    Mass spectrometry imaging by Fourier transform ion cyclotron resonance (FT-ICR) yields hundreds of unique peaks, many of which cannot be resolved by lower performance mass spectrometers. The high mass accuracy and high mass resolving power allow confident identification of small molecules and lipids directly from biological tissue sections. Here, calibration strategies for FT-ICR MS imaging were investigated. Sub-parts-per-million mass accuracy is demonstrated over an entire tissue section. Ion abundance fluctuations are corrected by addition of total and relative ion abundances for a root-mean-square error of 0.158 ppm on 16,764 peaks. A new approach for visualization of FT-ICR MS imaging data at high resolution is presented. The "Mosaic Datacube" provides a flexible means to visualize the entire mass range at a mass spectral bin width of 0.001 Da. The high resolution Mosaic Datacube resolves spectral features not visible at lower bin widths, while retaining the high mass accuracy from the calibration methods discussed.

  19. Fast Filtered Imaging of the C-2U Advanced Beam-Driven Field-Reversed Configuration

    NASA Astrophysics Data System (ADS)

    Granstedt, E. M.; Petrov, P.; Knapp, K.; Cordero, M.; Patel, V.; the TAE Team

    2015-11-01

    The goal of the C-2U program is to sustain a Field-Reversed Configuration (FRC) for 5+ ms using neutral beam injection, end-biasing, and various particle fueling techniques. Three high-speed, filtered cameras are used to observe visible light emission from deuterium pellet ablation and compact-toroid injection which are used for auxiliary particle fueling. The instruments are also used to view the dynamics of the macroscopic plasma evolution, identify regions of strong plasma-material interactions, and visualize non-axisymmetric perturbations. To achieve the necessary viewing geometry, imaging lenses are mounted in re-entrant viewports, two of which are mounted on bellows for retraction during gettering and removal if cleaning is necessary. Images are coupled from the imaging lens to the camera via custom lens-based optical periscopes. Each instrument contains a remote-controlled filter wheel which is set between shots to select a particular emission line from neutral D or various charge states of He, C, O, or Ti. Measurements of absolute emissivity and estimates of neutral and impurity density will be presented.

  20. Advances in feature selection methods for hyperspectral image processing in food industry applications: a review.

    PubMed

    Dai, Qiong; Cheng, Jun-Hu; Sun, Da-Wen; Zeng, Xin-An

    2015-01-01

    There is an increased interest in the applications of hyperspectral imaging (HSI) for assessing food quality, safety, and authenticity. HSI provides abundance of spatial and spectral information from foods by combining both spectroscopy and imaging, resulting in hundreds of contiguous wavebands for each spatial position of food samples, also known as the curse of dimensionality. It is desirable to employ feature selection algorithms for decreasing computation burden and increasing predicting accuracy, which are especially relevant in the development of online applications. Recently, a variety of feature selection algorithms have been proposed that can be categorized into three groups based on the searching strategy namely complete search, heuristic search and random search. This review mainly introduced the fundamental of each algorithm, illustrated its applications in hyperspectral data analysis in the food field, and discussed the advantages and disadvantages of these algorithms. It is hoped that this review should provide a guideline for feature selections and data processing in the future development of hyperspectral imaging technique in foods.