Science.gov

Sample records for advanced injection timing

  1. The Effect of the Time of Injection of Intrathecal Analgesia on the Length of Early and Advanced Labor

    DTIC Science & Technology

    2007-11-02

    community (See Table 1). The average time for each stage for a patient receiving intravenous oxytocin infusion is also included in Table 1. Table 1. Mean...received an intrathecal injection of fentanyl 25 to 30 rig, plus 0.25 to 0.3 mg of morphine and six to eight mg of one percent lidocaine were compared to

  2. Application of advanced diesel technology to inland waterway towboats. variable timing, electronic fuel injection. Final report, September 1985-January 1989

    SciTech Connect

    Rowland, D.P.

    1989-03-01

    This report represents the test and evaluation of advanced diesel technology components on the DDC Series 149 Marine engine. The tests were conducted on an inland-waterways towboat and consist of over 20,000 engine hours of operation during the testing. The Detroit Diesel Series 16V-149 engine rated at 900 SHP was tested aboard the M/V ESCATAWPA owned and operated by Warrior and Gulf Navigation Company. Both port and starboard engines were instrumented to measure engine operating parameters, propeller-shaft torque, and fuel consumption. The data were collected by a computer-based data-acquisition system and written to floppy disc for analysis. The tasks included: (1) baseline evaluation of naturally-aspirated (NA) engines; (2) upgrade both engines to turbocharged intercooled and blower bypassed (TIB) configuration and measure performance; (3) upgrade port engine with Detroit Diesel electronic control (DDEC) and measure performance; (4) change port engine to high-torque rise governor setting and measure performance; (5) upgrade starboard engine with DDEC.

  3. LIGHT SOURCE: Conceptual design of Hefei Advanced Light Source (HALS) injection system

    NASA Astrophysics Data System (ADS)

    Zhang, Shan-Cai; Wang, Lin; Feng, Guang-Yao; Wu, Cong-Feng; Li, Wei-Min; Xu, Hong-Liang; Liu, Zu-Ping

    2009-06-01

    The Hefei Advanced Light Source(HALS) is a super low emittance storage ring and has a very short beam life time. In order to run the ring stablely, top-up injection will be necessary. The injection system will greatly affect the quality of beam. This article first gives a physics design of the injecting system. Then the injecting system is tracked under different errors. The responses of storage beam and injecting beam are given in the article.

  4. Diesel engine fuel injection pump capable of injection timing adjustment

    SciTech Connect

    Wakasa, S.; Okazaki, T.

    1987-12-15

    A diesel engine fuel injection pump capable of injection timing adjustment is described comprising: (a) housing means; (b) a plunger assembly reciprocably mounted within the housing means and defining a pumping chamber therein; (c) the housing means having defined therein a fuel inlet port to the pumping chamber in a predetermined position in the longitudinal direction of the pumping chamber; (d) drive means for reciprocably moving the plunger assembly within the pumping chamber between a first extreme position; (e) the plunger assembly being formed of at least two transversely split segments movable toward and away from each other within limits and including resilient means biasing the segments of the plunger assembly toward each other; and (f) the housing means further including a timing fluid inlet port for introduction of a timing fluid under variable pressure between the segments of the plunger assembly to move the plunger assembly segments away from each other to an extent that timing fluid pressure is counterbalanced by force of the resilient means for controllably varying the distance therebetween and, in consequence, for varying the prestroke of the plunger assembly solely in response to variation of the timing fluid pressure to effect adjustment of injection timing.

  5. An Optical Method for Measuring Injection Timing in Diesel Engines, Using a Single Port

    DTIC Science & Technology

    2014-09-01

    injection timing using samples that included unrefined soybean oil, soy-oil based biodiesel, a paraffinic distillate (Norpar-13), ultra-low sulfur diesel...advance associated with both soybean oil methyl ester and yellow grease methyl ester 15 biodiesel originated with a SOI advance. This was due both

  6. Fuel injection pump with adjustable timing

    SciTech Connect

    Nakamura, H.; Abe, N.

    1987-04-28

    A fuel injection pump is described comprising: a pump body; a plunger disposed in the pump body for reciprocating within the pump body; and a pre-stroke adjusting mechanism disposed in the pump body and operatively connected with the plunger for adjusting an effective pre-stroke of the plunger.

  7. Electron acceleration with advanced injection methods at the ASTRA laser

    NASA Astrophysics Data System (ADS)

    Poder, Kristjan; Carreira-Lopes, Nelson; Wood, Jonathan; Cole, Jason; Dangor, Bucker; Foster, Peta; Gopal, Ram; Kamperidis, Christos; Kononenko, Olena; Mangles, Stuart; Olgun, Halil; Palmer, Charlotte; Symes, Daniel; Pattathil, Rajeev; Najmudin, Zulfikar; Imperial College London Team; Central Laser Facility Collaboration; Tata InsituteFundamental Research Collaboration; DESY Collaboration

    2015-11-01

    Recent electron acceleration results from the ASTRA laser facility are presented. Experiments were performed using both the 40 TW ASTRA and the 350 TW ASTRA-Gemini laser. Fundamental electron beam properties relating to its quality were investigated both experimentally and with PIC simulations. For increased control over such parameters, various injection mechanisms such as self-injection and ionization injection were employed. Particular interest is given to the dynamics of ionization injected electrons in strongly driven wakes.

  8. Injection timing control device for distributor-type fuel injection pumps

    SciTech Connect

    Sakuranaka, T.

    1986-09-09

    This patent describes an injection timing control device for combination with a fuel injection pump for an internal combustion engine, the pump being of the type having a suction space filled with fuel under pressure variable as a function of the rotational speed of the engine, a pumping and distributing plunger, and a roller holder carrying rollers circumferentially arranged and disposed in camming engagement with the plunger the injection timing control device comprising: a cylinder; a timer piston slidably received within the cylinder. The timer piston is coupled to the roller holder such that displacement thereof causes a corresponding change in the cicumferential position of the roller holder,; a first chamber defined at one end of the timer piston; a second chamber defined at one end of the timer piston; a second chamber defined at an opposite end of the timer piston.

  9. Simulation Study of Injection Performance for the Advanced Photon Source Upgrade

    SciTech Connect

    Xiao, A.; Sajaev, V.

    2015-01-01

    A vertical on-axis injection scheme has been proposed for the hybrid seven-bend-achromat (H7BA) [1] Advanced Photon Source upgrade (APSU) lattice. In order to evaluate the injection performance, various errors, such as injection beam jitter, optical mismatch and errors, and injection element errors have been investigated and their significance has been discovered. Injection efficiency is then simulated under different error levels. Based on these simulation results, specifications and an error-budget for individual systems have been defined.

  10. Effect of timed secondary-air injection on automotive emissions

    NASA Technical Reports Server (NTRS)

    Coffin, K. P.

    1973-01-01

    A single cylinder of an automotive V-8 engine was fitted with an electronically timed system for the pulsed injection of secondary air. A straight-tube exhaust minimized any mixing other than that produced by secondary-air pulsing. The device was operated over a range of engine loads and speeds. Effects attributable to secondary-air pulsing were found, but emission levels were generally no better than using the engine's own injection system. Under nontypical fast-idle, no-load conditions, emission levels were reduced by roughly a factor of 2.

  11. Advanced information processing system: Fault injection study and results

    NASA Technical Reports Server (NTRS)

    Burkhardt, Laura F.; Masotto, Thomas K.; Lala, Jaynarayan H.

    1992-01-01

    The objective of the AIPS program is to achieve a validated fault tolerant distributed computer system. The goals of the AIPS fault injection study were: (1) to present the fault injection study components addressing the AIPS validation objective; (2) to obtain feedback for fault removal from the design implementation; (3) to obtain statistical data regarding fault detection, isolation, and reconfiguration responses; and (4) to obtain data regarding the effects of faults on system performance. The parameters are described that must be varied to create a comprehensive set of fault injection tests, the subset of test cases selected, the test case measurements, and the test case execution. Both pin level hardware faults using a hardware fault injector and software injected memory mutations were used to test the system. An overview is provided of the hardware fault injector and the associated software used to carry out the experiments. Detailed specifications are given of fault and test results for the I/O Network and the AIPS Fault Tolerant Processor, respectively. The results are summarized and conclusions are given.

  12. Optimization and modeling studies for obtaining high injection efficiency at the Advanced Photon Source.

    SciTech Connect

    Emery, L.; APS Operations Division

    2005-01-01

    In recent years, the optics of the Advanced Photon Source storage ring has evolved to a lower equilibrium emittance (2.5 nm-rad) at the cost of stronger sextupoles and stronger nonlinearities, which have reduced the injection efficiency from the virtual 100% of the high emittance mode. Over the years we have developed a series of optimizations, measurements, and modeling studies of the injection process, which allows us to obtain or maintain low injection losses. The above will be described along with the injection configuration.

  13. Fuel injection control based on spill port opening timing correction

    SciTech Connect

    Ban, M.; Miyaki, M.; Hasegawa, T.; Kobayashi, F.; Kobashi, M.

    1988-08-30

    This patent describes a fuel injection control system for an internal combustion engine, comprising: (a) a fuel injection pump including: a pump chamber; a low pressure chamber; plunger means reciprocating in synchronism with rotation of the engine for introducing fuel into the pump chamber, and for feeding the fuel under pressure from the pump chamber to a cylinder of the engine, detector means for detecting a reference position of the plunger, and for generating a detection signal indicative of the reference position, and a spill port coupled to the pump chamber and in communication with the low pressure chamber, (b) solenoid valve means for opening and closing the spill port; (c) first circuit means including first and second adjusting resistors, the first circuit means being replaceably disposed on the fuel injection pump; (d) first control means for calculating a fuel injection time period according to operating conditions of the engine; (e) second control means including second circuit means comprising first and second fixed resistors, the first fixed resistor being connected to the first adjusting resistor so as to produce a first voltage signal corresponding to a ratio of a resistance value of the first adjusting resistor to a resistance value of the first fixed resistor.

  14. Advanced Gasoline Turbocharged Direction Injection (GTDI) Engine Development

    SciTech Connect

    Wagner, Terrance

    2015-12-31

    This program was undertaken in response to US Department of Energy Solicitation DE-FOA-0000079, resulting in a cooperative agreement with Ford and MTU to demonstrate improvement of fuel efficiency in a vehicle equipped with an advanced GTDI engine. Ford Motor Company has invested significantly in GTDI engine technology as a cost effective, high volume, fuel economy solution, marketed globally as EcoBoost technology. Ford envisions additional fuel economy improvement in the medium and long term by further advancing EcoBoost technology. The approach for the project was to engineer a comprehensive suite of gasoline engine systems technologies to achieve the project objectives, and to progressively demonstrate the objectives via concept analysis / computer modeling, single-cylinder and multi-cylinder engine testing on engine dynamometer, and vehicle level testing on chassis rolls.

  15. Effects of injection pressure and injection timing to exhaust gas opacity for a conventional indirect diesel engine

    NASA Astrophysics Data System (ADS)

    Budiman, Agus; Majid, Akmal Irfan; Pambayun, Nirmala Adhi Yoga; Yuswono, Lilik Chaerul; Sukoco

    2016-06-01

    In relation to pollution control and environmental friendliness, the quality of exhaust gas from diesel engine needs to be considered. The influences of injection pressure and timing to exhaust gas opacity were investigated. A series of experiments were conducted in a one-cylinder conventional diesel engine with a naturally aspirated system and indirect injection. The default specification of injection pressure was 120 kg/cm2. To investigate the injection pressure, the engine speed was retained on 1000 rpm with pressure variations from 80 to 215 kg/cm2. On the other hand, the various injection timing (8, 10, 12, 16 degrees before TDC point and exact 18 degrees before TDC point) were used to determine their effects to exhaust gas opacity. In this case, the engine speed was varied from 1000 to 2400 rpm. The injector tester was used to measure injection pressure whereas the exhaust gas opacity was determined by the smoke meter. Those data were also statistically analyzed by product moment correlation. As the results, the injection pressure of diesel engine had a non-significant positive correlation to the exhaust gas opacity with r = 0.113 and p > 5 %. Injection pressure should be adjusted to the specification listed on the diesel engine as if it was too high or too low will lead to the higher opacity. Moreover, there was a significant positive correlation between injection timing and the exhaust gas opacity in all engine speeds.

  16. Performance Measurements of the Injection Laser System Configured for Picosecond Scale Advanced Radiographic Capability

    SciTech Connect

    Haefner, L C; Heebner, J E; Dawson, J W; Fochs, S N; Shverdin, M Y; Crane, J K; Kanz, K V; Halpin, J M; Phan, H H; Sigurdsson, R J; Brewer, S W; Britten, J A; Brunton, G K; Clark, W J; Messerly, M J; Nissen, J D; Shaw, B H; Hackel, R P; Hermann, M R; Tietbohl, G L; Siders, C W; Barty, C J

    2009-10-23

    We have characterized the Advanced Radiographic Capability injection laser system and demonstrated that it meets performance requirements for upcoming National Ignition Facility fusion experiments. Pulse compression was achieved with a scaled down replica of the meter-scale grating ARC compressor and sub-ps pulse duration was demonstrated at the Joule-level.

  17. Linearisation via input-output injection of time delay systems

    NASA Astrophysics Data System (ADS)

    García-Ramírez, Eduardo; Moog, Claude H.; Califano, Claudia; Alejandro Márquez-Martínez, Luis

    2016-06-01

    This paper deals with the problem of linearisation of systems with constant commensurable delays by input-output injection using algebraic control tools based on the theory of non-commutative rings. Solutions for the problem of linearisation free of delays, and with delays of an observable nonlinear time-delay systems are presented based on the analysis of the input-output equation. These results are achieved by means of constructive algorithms that use the nth derivative of the output expressed in terms of the state-space variables instead of the explicit computation of the input-output representation of the system. Necessary and sufficient conditions are established in both cases by means of an invertible change of coordinates.

  18. Fishbone activity in experimental advanced superconducting tokamak neutral beam injection plasma

    NASA Astrophysics Data System (ADS)

    Xu, Liqing; Zhang, Jizong; Chen, Kaiyun; Hu, Liqun; Li, Erzhong; Lin, Shiyao; Shi, Tonghui; Duan, Yanmin; Zhu, Yubao

    2015-12-01

    Repetitive fishbones near the trapped ion procession frequency were observed for the first time in the neutral beam injection high confinement plasmas in Experimental Advanced Superconducting Tokamak (EAST) tokamak, and diagnosed using a solid-state neutral particle analyzer based on a compact silicon photodiode together with an upgraded high spatial-temporal-resolution multi-arrays soft X-ray (SX) system. This 1/1 typical internal kink mode propagates in the ion-diamagnetism direction with a rotation speed faster than the bulk plasma in the plasma frame. From the SX measurements, this mode frequency is typical of chirping down and the energetic particle effect related to the twisting mode structure. This ion fishbone was found able to trigger a multiple core sawtooth crashes with edge-2/1 sideband modes, as well as to lead to a transition from fishbone to long lived saturated kink mode to fishbone. Furthermore, using SX tomography, a correlation between mode amplitude and mode frequency was found. Finally, a phenomenological prey-predator model was found to reproduce the fishbone nonlinear process well.

  19. Fishbone activity in experimental advanced superconducting tokamak neutral beam injection plasma

    SciTech Connect

    Xu, Liqing; Zhang, Jizong; Chen, Kaiyun E-mail: lqhu@ipp.cas.cn; Hu, Liqun E-mail: lqhu@ipp.cas.cn; Li, Erzhong; Lin, Shiyao; Shi, Tonghui; Duan, Yanmin; Zhu, Yubao

    2015-12-15

    Repetitive fishbones near the trapped ion procession frequency were observed for the first time in the neutral beam injection high confinement plasmas in Experimental Advanced Superconducting Tokamak (EAST) tokamak, and diagnosed using a solid-state neutral particle analyzer based on a compact silicon photodiode together with an upgraded high spatial-temporal-resolution multi-arrays soft X-ray (SX) system. This 1/1 typical internal kink mode propagates in the ion-diamagnetism direction with a rotation speed faster than the bulk plasma in the plasma frame. From the SX measurements, this mode frequency is typical of chirping down and the energetic particle effect related to the twisting mode structure. This ion fishbone was found able to trigger a multiple core sawtooth crashes with edge-2/1 sideband modes, as well as to lead to a transition from fishbone to long lived saturated kink mode to fishbone. Furthermore, using SX tomography, a correlation between mode amplitude and mode frequency was found. Finally, a phenomenological prey–predator model was found to reproduce the fishbone nonlinear process well.

  20. Angular-divergence calculation for Experimental Advanced Superconducting Tokamak neutral beam injection ion source based on spectroscopic measurements

    SciTech Connect

    Chi, Yuan; Hu, Chundong; Zhuang, Ge

    2014-02-15

    Calorimetric method has been primarily applied for several experimental campaigns to determine the angular divergence of high-current ion source for the neutral beam injection system on the Experimental Advanced Superconducting Tokamak (EAST). A Doppler shift spectroscopy has been developed to provide the secondary measurement of the angular divergence to improve the divergence measurement accuracy and for real-time and non-perturbing measurement. The modified calculation model based on the W7AS neutral beam injectors is adopted to accommodate the slot-type accelerating grids used in the EAST's ion source. Preliminary spectroscopic experimental results are presented comparable to the calorimetrically determined value of theoretical calculation.

  1. Advances in time-of-flight PET

    PubMed Central

    Surti, Suleman; Karp, Joel S.

    2016-01-01

    This paper provides a review and an update on time-of-flight PET imaging with a focus on PET instrumentation, ranging from hardware design to software algorithms. We first present a short introduction to PET, followed by a description of TOF PET imaging and its history from the early days. Next, we introduce the current state-of-art in TOF PET technology and briefly summarize the benefits of TOF PET imaging. This is followed by a discussion of the various technological advancements in hardware (scintillators, photo-sensors, electronics) and software (image reconstruction) that have led to the current widespread use of TOF PET technology, and future developments that have the potential for further improvements in the TOF imaging performance. We conclude with a discussion of some new research areas that have opened up in PET imaging as a result of having good system timing resolution, ranging from new algorithms for attenuation correction, through efficient system calibration techniques, to potential for new PET system designs. PMID:26778577

  2. Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction

    PubMed Central

    Yoshizumi, Tomo; Zhu, Yang; Jiang, Hongbin; D’Amore, Antonio; Sakaguchi, Hirokazu; Tchao, Jason; Tobita, Kimimasa; Wagner, William R.

    2016-01-01

    Intramyocardial injection of various injectable hydrogel materials has shown benefit in positively impacting the course of left ventricular (LV) remodeling after myocardial infarction (MI). However, since LV remodeling is a complex, time dependent process, the most efficacious time of hydrogel injection is not clear. In this study, we injected a relatively stiff, thermoresponsive and bioabsorbable hydrogel in rat hearts at 3 different time points - immediately after MI (IM), 3 d post-MI (3D), and 2 w post-MI (2W), corresponding to the beginnings of the necrotic, fibrotic and chronic remodeling phases. The employed left anterior descending coronary artery ligation model showed expected infarction responses including functional loss, inflammation and fibrosis with distinct time dependent patterns. Changes in LV geometry and contractile function were followed by longitudinal echocardiography for 10 w post-MI. While all injection times positively affected LV function and wall thickness, the 3D group gave better functional outcomes than the other injection times and also exhibited more local vascularization and less inflammatory markers than the earlier injection time. The results indicate an important role for injection timing in the increasingly explored concept of post-MI biomaterial injection therapy and suggest that for hydrogels with mechanical support as primary function, injection at the beginning of the fibrotic phase may provide improved outcomes. PMID:26774561

  3. Timing effect of intramyocardial hydrogel injection for positively impacting left ventricular remodeling after myocardial infarction.

    PubMed

    Yoshizumi, Tomo; Zhu, Yang; Jiang, Hongbin; D'Amore, Antonio; Sakaguchi, Hirokazu; Tchao, Jason; Tobita, Kimimasa; Wagner, William R

    2016-03-01

    Intramyocardial injection of various injectable hydrogel materials has shown benefit in positively impacting the course of left ventricular (LV) remodeling after myocardial infarction (MI). However, since LV remodeling is a complex, time dependent process, the most efficacious time of hydrogel injection is not clear. In this study, we injected a relatively stiff, thermoresponsive and bioabsorbable hydrogel in rat hearts at 3 different time points - immediately after MI (IM), 3 d post-MI (3D), and 2 w post-MI (2W), corresponding to the beginnings of the necrotic, fibrotic and chronic remodeling phases. The employed left anterior descending coronary artery ligation model showed expected infarction responses including functional loss, inflammation and fibrosis with distinct time dependent patterns. Changes in LV geometry and contractile function were followed by longitudinal echocardiography for 10 w post-MI. While all injection times positively affected LV function and wall thickness, the 3D group gave better functional outcomes than the other injection times and also exhibited more local vascularization and less inflammatory markers than the earlier injection time. The results indicate an important role for injection timing in the increasingly explored concept of post-MI biomaterial injection therapy and suggest that for hydrogels with mechanical support as primary function, injection at the beginning of the fibrotic phase may provide improved outcomes.

  4. Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate.

    PubMed

    Sartorius, Gideon; Fennell, Carolyn; Spasevska, Sasa; Turner, Leo; Conway, Ann J; Handelsman, David J

    2010-03-01

    Pain following depot intramuscular (IM) injection of oil vehicle-based drugs has been little studied. This study aimed to determine prospectively the prevalence, determinants, severity and functional consequences of pain during the week after IM injection of 1 000 mg testosterone undecanoate (TU) in a 4-mL castor oil vehicle. Androgen-deficient men receiving regular T replacement therapy at an academic andrology clinic were recruited to report pain scores using a coloured visual linear analogue scale at seven times over the first day and daily for a week after a deep IM gluteal injection. The time course and covariables influencing pain scores were analysed by mixed model analysis of variance (ANOVA). Following 168 injections in 125 men, pain was reported by 80% of men, peaking immediately after injection, reaching only moderate severity, lasting 1-2 days and returning to baseline by day 4. The pain required little analgesic use and produced minimal interference in daily activities. The time course of pain scores was reproducible in the 43 men who underwent two consecutive injections. Pain was more severe in men who had an earlier painful injection, but less severe in older and more obese men. There were negligible differences in post-injection pain experience between experienced nurses administering injections. Deep IM gluteal injection of depot TU in 4-mL castor oil is well tolerated and post-injection pain is influenced by earlier painful injection experience, as well as age and obesity.

  5. 10 CFR 75.44 - Timing of advance notification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Timing of advance notification. 75.44 Section 75.44 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Advanced Notification and Expenses § 75.44 Timing of advance notification. (a) Except as...

  6. 10 CFR 75.44 - Timing of advance notification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Timing of advance notification. 75.44 Section 75.44 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Advanced Notification and Expenses § 75.44 Timing of advance notification. (a) Except as...

  7. 10 CFR 75.44 - Timing of advance notification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Timing of advance notification. 75.44 Section 75.44 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Advanced Notification and Expenses § 75.44 Timing of advance notification. (a) Except as...

  8. 10 CFR 75.44 - Timing of advance notification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Timing of advance notification. 75.44 Section 75.44 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Advanced Notification and Expenses § 75.44 Timing of advance notification. (a) Except as...

  9. 10 CFR 75.44 - Timing of advance notification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Timing of advance notification. 75.44 Section 75.44 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Advanced Notification and Expenses § 75.44 Timing of advance notification. (a) Except as...

  10. Seawater injection barrier recharge with advanced reclaimed water at Llobregat delta aquifer (Spain).

    PubMed

    Ortuño, F; Molinero, J; Garrido, T; Custodio, E

    2012-01-01

    The main aquifer of the Llobregat delta (Barcelona, Spain) has been affected by seawater intrusion since the 1960s. The Catalan Water Agency (ACA) has sponsored the construction of a positive hydraulic barrier in order to stop the progress of seawater intrusion advance due to the intensive aquifer development. The hydraulic barrier consists of 15 wells into which highly treated reclaimed water from the waste water treatment plant of the Baix Llobregat is injected. Water is subjected, prior to the distribution to the injection wells, to secondary and tertiary treatments, and later to ultrafiltration, UV disinfection without chlorination, and salinity reduction through reverse osmosis. A preliminary pilot phase of the project was started in late 2007, with highly positive results, and the second phase started in mid 2010. Hydrogeological and hydrochemical monitoring data indicate an efficient performance and aquifer improvement. The evaluation of such efficiency and operational costs has been analyzed and discussed.

  11. Influence of injection timing on severity of cadmium-induced testicular toxicity in mice.

    PubMed

    Ohtani, Katsumi; Yanagiba, Yukie; Ashimori, Atsushige; Takeuchi, Asuka; Takada, Naoko; Togawa, Masako; Hasegawa, Tatsuya; Ikeda, Masayuki; Miura, Nobuhiko

    2013-02-01

    Cadmium (Cd) is one of the endocrine disrupter and is a well-known testicular toxicant. Recently, we reported that Cd-induced mortality was markedly different by injection timing. In this report, we investigated whether severity of testicular toxicity was affected by injection timing of Cd. C57BL/6J mice (male, 7 w) were received single intraperitoneal injection of CdCl(2) (4.5 mg/kg) at zeitgeber time 6 (ZT6) or ZT18; these injection timings showed highest (ZT6) or lowest (ZT18) mortality in our previous study (Miura, 2012). After one week of the injection, several parameters for testicular toxicity such as epididymal sperm motility and numbers of sperm head both in cauda epididymidis and testis were measured. At ZT6 injection group, all parameters examined were significantly reduced compared to the control group. However, very interestingly, no significant changes were observed at ZT18 injection group. We obtained similar results by another experiment in which mice were received single subcutaneous injection of CdCl(2) (4 or 6 mg/kg) followed by measuring the parameters ten days after the injection. This diurnal variation was not contradictory to the result of the lethal toxicity which we showed earlier. Therefore, our results indicate that the testicular toxicity of Cd is also influenced by the injection timing.

  12. A low loss Faraday isolator for squeezed vacuum injection in Advanced LIGO

    NASA Astrophysics Data System (ADS)

    Goetz, Ryan; Tanner, David; Mueller, Guido

    2016-03-01

    Using conventional interferometry, the strain sensitivity of Advanced LIGO is limited by a quantum noise floor known as the standard quantum limit (SQL). Injecting squeezed vacuum states into the output port of the interferometer allows for detector sensitivities below the SQL at frequencies within a band of observational interest. The effectiveness of squeezing in reducing quantum noise is strongly dependent upon the optical loss in the squeezed path. Thus, to combine the squeezed vacuum state with the interferometer output we require a Faraday isolator with both high power-throughput efficiency and high isolation ratio. A prototype isolator is currently being developed, and we will discuss the design goals and current status.

  13. Advances in Steady Inductive Helicity Injection for Plasma Startup and Toroidal Current Drive

    NASA Astrophysics Data System (ADS)

    Victor, Brian S.; Jarboe, Thomas R.; Hossack, Aaron C.; Ennis, David A.; Nelson, Brian A.; Hansen, Chris J.; Wrobel, Jonathan S.

    The Helicity Injected Torus with Steady Inductive Helicity Injection (HIT-SI) has achieved a breakthrough in the development of a new method of toroidal plasma startup and current drive. HIT-SI accomplishes helicity injection current drive on a spheromak of major radius 0.3 m with two injectors driven sinusoidally at 14.5 kHz. Results include the first sustainment of toroidal plasma current of over 50 kA at up to 3 times the injected currents added in quadrature. Separatrix toroidal currents—currents not linking the helicity injectors—are sustained at up to 40 kA. Toroidal currents persist for up to 0.65 ms after the injectors are turned off. Results are achieved after helium operations condition the alumina plasma-facing surface. The conditioned alumina walls then act to pump the deuterium, thereby reducing the spheromak density. High performance discharges (Itor/Iinj ≥ 2) are characterized by a decrease in the n = 1 mode activity measured by surface probes near the midplane of the confinement volume. Suppression of internal magnetic fields (measured by an internal probe) below the predicted Taylor equilibrium indicates that the magnetic fields in HIT-SI can no longer be described by a zero pressure, constant λ equilibrium.

  14. Intravitreal Injection of Bone Marrow Mesenchymal Stem Cells in Patients with Advanced Retinitis Pigmentosa; a Safety Study

    PubMed Central

    Satarian, Leila; Nourinia, Ramin; Safi, Sare; Kanavi, Mozhgan Rezaei; Jarughi, Neda; Daftarian, Narsis; Arab, Leila; Aghdami, Nasser; Ahmadieh, Hamid; Baharvand, Hossein

    2017-01-01

    Purpose: To examine the safety of a single intravitreal injection of autologous bone Marrow Mesenchymal stem cells (MSCs) in patients with advanced retinitis pigmentosa (RP). Methods: A prospective, phase I, nonrandomized, open-label study was conducted on 3 eyes of 3 volunteers with advanced RP. Visual acuity, slit-lamp examination, fundus examination, optical coherence tomography, fundus auto-fluorescence, fluorescein angiography and multifocal electroretinography were performed before and after an intravitreal injection of approximately one-million MSCs. The patients were followed for one year. Further evaluation of MSCs was performed by injection of these cells into the mouse vitreous cavity. Results: No, adverse events were observed in eyes of 2 out of 3 patients after transplantation of MSCs. These patients reported improvements in perception of the light after two weeks, which lasted for 3 months. However, severe fibrous tissue proliferation was observed in the vitreous cavity and retrolental space of the third patient's eye, which led to tractional retinal detachment (TRD), iris neovascularization and formation of mature cataract. Injection of this patient's MSCs into the vitreous cavity of mice also resulted in fibrosis; however, intravitreal injections of the two other patients' cells into the mouse vitreous did not generate any fibrous tissue. Conclusion: Intravitreal injection of autologous bone marrow MSCs into patients' eyes with advanced RP does not meet safety standards. Major side effects of this therapy can include fibrosis and TRD. We propose thorough evaluation of MSCs prior to transplantation by intravitreal injection in the laboratory animals.\\ PMID:28299008

  15. Advanced in-duct sorbent injection for SO{sub 2} control. Final technical report

    SciTech Connect

    Stouffer, M.R.; Withium, J.A.; Rosenhoover, W.A.; Maskew, J.T.

    1994-12-01

    The objective of this research project was to develop a second generation duct sorbent injection technology as a cost-effective compliance option for the 1990 Clean Air Act Amendments. Research and development work was focused on the Advanced Coolside process, which showed the potential for exceeding the original performance targets of 90% SO{sub 2} removal and 60% sorbent utilization. Process development was conducted in a 1000 acfm pilot plant. The pilot plant testing showed that the Advanced Coolside process can achieve 90% SO{sub 2} removal at sorbent utilizations up to 75%. The testing also showed that the process has the potential to achieve very high removal efficiency (90 to >99%). By conducting conceptual process design and economic evaluations periodically during the project, development work was focused on process design improvements which substantially lowered process capital and operating costs, A final process economic study projects capital costs less than one half of those for limestone forced oxidation wet FGD. Projected total SO{sub 2} control cost is about 25% lower than wet FGD for a 260 MWe plant burning a 2.5% sulfur coal. A waste management study showed the acceptability of landfill disposal; it also identified a potential avenue for by-product utilization which should be further investigated. Based on the pilot plant performance and on the above economic projections, future work to scale up the Advanced Coolside process is recommended.

  16. Some Effects of Injection Advance Angle, Engine-Jacket Temperature, and Speed on Combustion in a Compression-Ignition Engine

    NASA Technical Reports Server (NTRS)

    Rothrock, A M; Waldron, C D

    1936-01-01

    An optical indicator and a high-speed motion-picture camera capable of operating at the rate of 2,000 frames per second were used to record simultaneously the pressure development and the flame formation in the combustion chamber of the NACA combustion apparatus. Tests were made at engine speeds of 570 and 1,500 r.p.m. The engine-jacket temperature was varied from 100 degrees to 300 degrees F. And the injection advance angle from 13 degrees after top center to 120 degrees before top center. The results show that the course of the combustion is largely controlled by the temperature and pressure of the air in the chamber from the time the fuel is injected until the time at which combustion starts and by the ignition lag. The conclusion is presented that in a compression-ignition engine with a quiescent combustion chamber the ignition lag should be the longest that can be used without excessive rates of pressure rise; any further shortening of the ignition lag decreased the effective combustion of the engine.

  17. Advances in Time-Distance Helioseismology

    NASA Technical Reports Server (NTRS)

    Duvall, Thomas L., Jr.; Beck, John G.; Gizon, Laurent; Kosovichev, Alexander F.; Oegerle, William (Technical Monitor)

    2002-01-01

    Time-distance helioseismology is a way to measure travel times between surface locations for waves traversing the solar interior. Coupling the travel with an extensive modeling effort has proven to be a powerful tool for measuring flows and other wave speed inhomogeneities in the solar interior. Problems receiving current attention include studying the time variation of the meridional circulation and torsional oscillation and active region emergence and evolution, current results on these topics will be presented.

  18. Advances in coincidence time resolution for PET.

    PubMed

    Cates, Joshua W; Levin, Craig S

    2016-03-21

    Coincidence time resolution (CTR), an important parameter for time-of-flight (TOF) PET performance, is determined mainly by properties of the scintillation crystal and photodetector used. Stable production techniques for LGSO:Ce (Lu1.8Gd0.2SiO5:Ce) with decay times varying from ∼ 30-40 ns have been established over the past decade, and the decay time can be accurately controlled with varying cerium concentration (0.025-0.075 mol%). This material is promising for TOF-PET, as it has similar light output and equivalent stopping power for 511 keV annihilation photons compared to industry standard LSO:Ce and LYSO:Ce, and the decay time is improved by more than 30% with proper Ce concentration. This work investigates the achievable CTR with LGSO:Ce (0.025 mol%) when coupled to new silicon photomultipliers. Crystal element dimension is another important parameter for achieving fast timing. 20 mm length crystal elements achieve higher 511 keV photon detection efficiency, but also introduce higher scintillation photon transit time variance. 3 mm length crystals are not practical for PET, but have reduced scintillation transit time spread. The CTR between pairs of 2.9 × 2.9 × 3 mm(3) and 2.9 × 2.9 × 20 mm(3) LGSO:Ce crystals was measured to be 80 ± 4 and 122 ± 4 ps FWHM, respectively. Measurements of light yield and intrinsic decay time are also presented for a thorough investigation into the timing performance with LGSO:Ce (0.025 mol%).

  19. Advanced spectral methods for climatic time series

    USGS Publications Warehouse

    Ghil, M.; Allen, M.R.; Dettinger, M.D.; Ide, K.; Kondrashov, D.; Mann, M.E.; Robertson, A.W.; Saunders, A.; Tian, Y.; Varadi, F.; Yiou, P.

    2002-01-01

    The analysis of univariate or multivariate time series provides crucial information to describe, understand, and predict climatic variability. The discovery and implementation of a number of novel methods for extracting useful information from time series has recently revitalized this classical field of study. Considerable progress has also been made in interpreting the information so obtained in terms of dynamical systems theory. In this review we describe the connections between time series analysis and nonlinear dynamics, discuss signal- to-noise enhancement, and present some of the novel methods for spectral analysis. The various steps, as well as the advantages and disadvantages of these methods, are illustrated by their application to an important climatic time series, the Southern Oscillation Index. This index captures major features of interannual climate variability and is used extensively in its prediction. Regional and global sea surface temperature data sets are used to illustrate multivariate spectral methods. Open questions and further prospects conclude the review.

  20. Advanced Production Surface Preparation Technology Development for Ultra-High Pressure Diesel Injection

    SciTech Connect

    Grant, Marion B.

    2012-04-30

    In 2007, An Ultra High Injection Pressure (UHIP) fueling method has been demonstrated by Caterpillar Fuel Systems - Product Development, demonstrating ability to deliver U.S. Environment Protection Agency (EPA) Tier 4 Final diesel engine emission performance with greatly reduced emissions handling components on the engine, such as without NOx reduction after-treatment and with only a through-flow 50% effective diesel particulate trap (DPT). They have shown this capability using multiple multi-cylinder engine tests of an Ultra High Pressure Common Rail (UHPCR) fuel system with higher than traditional levels of CEGR and an advanced injector nozzle design. The system delivered better atomization of the fuel, for more complete burn, to greatly reduce diesel particulates, while CEGR or high efficiency NOx reduction after-treatment handles the NOx. With the reduced back pressure of a traditional DPT, and with the more complete fuel burn, the system reduced levels of fuel consumption by 2.4% for similar delivery of torque and horsepower over the best Tier 4 Interim levels of fuel consumption in the diesel power industry. The challenge is to manufacture the components in high-volume production that can withstand the required higher pressure injection. Production processes must be developed to increase the toughness of the injector steel to withstand the UHIP pulsations and generate near perfect form and finish in the sub-millimeter size geometries within the injector. This project resulted in two developments in 2011. The first development was a process and a machine specification by which a high target of compressive residual stress (CRS) can be consistently imparted to key surfaces of the fuel system to increase the toughness of the steel, and a demonstration of the feasibility of further refinement of the process for use in volume production. The second development was the demonstration of the feasibility of a process for imparting near perfect, durable geometry to

  1. The time lag and interval of discharge with a spring actuated fuel injection pump

    NASA Technical Reports Server (NTRS)

    Matthews, Robertson; Gardiner, A W

    1923-01-01

    Discussed here is research on a spring activated fuel pump for solid or airless injection with small, high speed internal combustion engines. The pump characteristics under investigation were the interval of fuel injection in terms of degrees of crank travel and in absolute time, the lag between the time the injection pump plunger begins its stroke and the appearance of the jet at the orifice, and the manner in which the fuel spray builds up to a maximum when the fuel valve is opened, and then diminishes.

  2. [Intravaginal ejaculatory latency time: Advances in studies].

    PubMed

    Wang, Wan-rong; Xie, Sheng

    2016-02-01

    Although premature ejaculation (PE) is a common type of male sexual dysfunction, to date we lack a unified definition of PE. The multidimensional definition of PE has been accepted by more and more clinicians. Intravaginal ejaculatory latency time (IELT) is one of the three important dimensions (time to ejaculation, inability to control or delay ejaculation, and negative consequences) for defining PE. Rapid ejaculation is one of the core symptoms of PE and IELT is an objective measurement as well as an important tool for the evaluation of PE. This article reviews estimated IELT, stopwatch-measured IELT, the correlation between estimated and stopwatch-measured IELT, and the factors affecting IELT in the general male population, PE patients, and those complaining of PE.

  3. Advances in NIF Shock Timing Experiments

    NASA Astrophysics Data System (ADS)

    Robey, Harry

    2012-10-01

    Experiments are underway to tune the shock timing of capsule implosions on the National Ignition Facility (NIF). These experiments use a modified cryogenic hohlraum geometry designed to precisely match the performance of ignition hohlraums. The targets employ a re-entrant Au cone to provide optical access to multiple shocks as they propagate in the liquid deuterium-filled capsule interior. The strength and timing of all four shocks is diagnosed with VISAR (Velocity Interferometer System for Any Reflector). Experiments are now routinely conducted in a mirrored keyhole geometry, which allows for simultaneous diagnosis of the shock timing at both the hohlraum pole and equator. Further modifications are being made to improve the surrogacy to ignition hohlraums by replacing the standard liquid deuterium (D2) capsule fill with a deuterium-tritium (DT) ice layer. These experiments will remove any possible surrogacy difference between D2 and DT as well as incorporate the physics of shock release from the ice layer, which is absent in current experiments. Experimental results and comparisons with numerical simulation are presented.

  4. [Time course of changes in aqueous flare following intravitreous gas injection in rabbits].

    PubMed

    Yamamoto, K

    1991-06-01

    The quantitative changes of the aqueous flare following intravitreous gas injection were determined by laser flare-cell metry in rabbits. A volume of 0.4 ml of air, 100% sulfur hexafluoride (SF6), or 100% perfluoropropane (C3F8), was injected separately into the vitreous of pigmented rabbits. The normal range of the aqueous flare was 7.8 +/- 3.0 (photon counts/msec). Each model showed an increase of aqueous flare on the first day (air: 18.9 +/- 9.1, SF6: 19.5 +/- 11.5, C3F8: 40.8 +/- 22.8). Subsequently, the aqueous flare of air-injected eyes gradually decreased, while that of SF6-injected eyes increased on the 4th day, and then gradually decreased. Also that of C3F8-injected eyes increased on the 4th day, and the 7th day, then decreased on the 14th day, but it was still higher than normal. Cataracts developed in two of the five eyes injected with SF6 and all of the four eyes injected with C3F8. These findings revealed that following intravitreous gas injection, disruption of the blood-ocular barrier depended on the expansibility of the gas and the length of time it remained in the vitreous cavity.

  5. Low-cost real-time infrared scene generation for image projection and signal injection

    NASA Astrophysics Data System (ADS)

    Buford, James A., Jr.; King, David E.; Bowden, Mark H.

    1998-07-01

    As cost becomes an increasingly important factor in the development and testing of Infrared sensors and flight computer/processors, the need for accurate hardware-in-the- loop (HWIL) simulations is critical. In the past, expensive and complex dedicated scene generation hardware was needed to attain the fidelity necessary for accurate testing. Recent technological advances and innovative applications of established technologies are beginning to allow development of cost-effective replacements for dedicated scene generators. These new scene generators are mainly constructed from commercial-off-the-shelf (COTS) hardware and software components. At the U.S. Army Aviation and Missile Command (AMCOM) Missile Research, Development, and Engineering Center (MRDEC), researchers have developed such a dynamic IR scene generator (IRSG) built around COTS hardware and software. The IRSG is used to provide dynamic inputs to an IR scene projector for in-band seeker testing and for direct signal injection into the seeker or processor electronics. AMCOM MRDEC has developed a second generation IRSG, namely IRSG2, using the latest Silicon Graphics Incorporated (SGI) Onyx2 with Infinite Reality graphics. As reported in previous papers, the SGI Onyx Reality Engine 2 is the platform of the original IRSG that is now referred to as IRSG1. IRSG1 has been in operation and used daily for the past three years on several IR projection and signal injection HWIL programs. Using this second generation IRSG, frame rates have increased from 120 Hz to 400 Hz and intensity resolution from 12 bits to 16 bits. The key features of the IRSGs are real time missile frame rates and frame sizes, dynamic missile-to-target(s) viewpoint updated each frame in real-time by a six-degree-of- freedom (6DOF) system under test (SUT) simulation, multiple dynamic objects (e.g. targets, terrain/background, countermeasures, and atmospheric effects), latency compensation, point-to-extended source anti-aliased targets, and

  6. My first time: initiation into injecting drug use in Manipur and Nagaland, north-east India

    PubMed Central

    Kermode, Michelle; Longleng, Verity; Singh, Bangkim Chingsubam; Hocking, Jane; Langkham, Biangtung; Crofts, Nick

    2007-01-01

    Background The north-east Indian states of Manipur and Nagaland are two of the six high HIV prevalence states in the country, and the main route of HIV transmission is injecting drug use. Understanding the pathways to injecting drug use can facilitate early intervention with HIV prevention programs. While several studies of initiation into injecting drug use have been conducted in developed countries, little is known about the situation in developing country settings. The aim of this study was to increase understanding of the contextual factors associated with initiation into injecting drug use in north-east India, and the influence of these factors on subsequent initiation of others. Method In mid 2006 a cross-sectional survey among 200 injecting drug users (IDUs) was undertaken in partnership with local NGOs that provide HIV prevention and care services and advocacy for IDUs in Imphal, Manipur and Dimapur, Nagaland. The questionnaire elicited detailed information about the circumstances of the first injection and the contexts of participants' lives. Demographic information, self-reported HIV status, and details about initiation of others were also recorded. Results Initiation into injecting drug use occurred at 20 years of age. The drugs most commonly injected were Spasmo-proxyvon (65.5%) and heroin (30.5%). In 53.5% cases, a needle belonging to someone else was used. Two-thirds (66.7%) had used the drug previously, and 91.0% had known other IDUs prior to initiation (mean = 7.5 others). The first injection was usually administered by another person (94.5%), mostly a friend (84.1%). Initiation is a social event; 98% had others present (mean = 2.7 others). Almost 70% of participants had initiated at least one other (mean = 5 others). Initiation of others was independently associated with being male and unemployed; having IDU friends and using alcohol around the time of initiation; and having been taught to inject and not paid for the drug at the time of initiation

  7. Development of the advanced coolside sorbent injection process for SO{sub 2}

    SciTech Connect

    Withum, J.A.; Maskew, J.T.; Rosenhoover, W.A.

    1995-11-01

    The goal of this work was to develop a low-capital-cost process capable of over 90% SO{sub 2} removal as an economically attractive option for compliance with the Clean Air Act. The Advanced Coolside Process uses a contactor to simultaneously remove fly ash and saturate the flue gas with water, followed by sorbent injection into the highly humid flue gas and collection of the sorbent by the existing particulate collector High sorbent utilization is achieved by sorbent recycle. The original performance targets of 90% SO{sub 2} removal and 60% sorbent utilization were exceeded in 1000 acfm pilot plant operations using commercial hydrated lime as the only sorbent. Process optimization simplified the process equipment, resulting in significant cost reduction. Recent accomplishments include completion of equipment testing and sorbent optimization, a waste management study, and a long-term performance test. An economic evaluation for the optimized process projects capital costs 55% to 60 % less than those of limestone forced oxidation wet FGD. The projected levelized control cost is 15% to 35% lower than wet FGD (25% lower for a 260 MWe plant burning a 2.5% sulfur coal), depending on plant size and coal sulfur content.

  8. Degarelix Injection

    MedlinePlus

    Degarelix injection is used to treat advanced prostate cancer (cancer that begins in the prostate [a male reproductive gland]). Degarelix injection is in a class of medications called gonadotropin-releasing hormone (GnRH) ...

  9. Towards Run-time Assurance of Advanced Propulsion Algorithms

    NASA Technical Reports Server (NTRS)

    Wong, Edmond; Schierman, John D.; Schlapkohl, Thomas; Chicatelli, Amy

    2014-01-01

    This paper covers the motivation and rationale for investigating the application of run-time assurance methods as a potential means of providing safety assurance for advanced propulsion control systems. Certification is becoming increasingly infeasible for such systems using current verification practices. Run-time assurance systems hold the promise of certifying these advanced systems by continuously monitoring the state of the feedback system during operation and reverting to a simpler, certified system if anomalous behavior is detected. The discussion will also cover initial efforts underway to apply a run-time assurance framework to NASA's model-based engine control approach. Preliminary experimental results are presented and discussed.

  10. Association between Hyaluronic Acid Injections and Time-to-Total Knee Replacement Surgery.

    PubMed

    Altman, Roy; Fredericson, Michael; Bhattacharyya, Samir K; Bisson, Brad; Abbott, Thomas; Yadalam, Sashidhar; Kim, Myoung

    2016-10-01

    This study assessed the association between hyaluronic acid (HA) injections and time-to-total knee replacement (TKR) surgery for patients with knee osteoarthritis (OA). Patients 18 to 64 years of age who had TKR surgery between January 1, 2006 and December 31, 2011 were identified from the MarketScan Commercial claims database. All patients had 6 years or more of continuous enrollment prior to TKR surgery. There were two cohorts (1) patients with HA injections prior to TKR surgery and (2) patients who did not have HA injections prior to TKR surgery. Time-to-TKR was defined as the total days from the date of diagnosis of knee OA on the patient's first visit to an orthopedic surgeon to the date of TKR surgery. Results included 22,555 patients who had TKR surgery: 14,132 in the non-HA and 8,423 in the HA cohort. In this retrospective analysis of patients undergoing TKR, the median Time-to-TKR surgery was 326 days for the non-HA and 908 days for the HA cohort, a difference of 582 days. Those receiving HA injections had a median 1.6-year longer Time-to-TKR surgery versus those who did not receive HA injections. These results have both clinical and economic implications.

  11. Advanced propeller noise prediction in the time domain

    NASA Technical Reports Server (NTRS)

    Farassat, F.; Dunn, M. H.; Spence, P. L.

    1992-01-01

    The time domain code ASSPIN gives acousticians a powerful technique of advanced propeller noise prediction. Except for nonlinear effects, the code uses exact solutions of the Ffowcs Williams-Hawkings equation with exact blade geometry and kinematics. By including nonaxial inflow, periodic loading noise, and adaptive time steps to accelerate computer execution, the development of this code becomes complete.

  12. Time parallelization of advanced operation scenario simulations of ITER plasma

    SciTech Connect

    Samaddar, D.; Casper, T. A.; Kim, S. H.; Berry, Lee A; Elwasif, Wael R; Batchelor, Donald B; Houlberg, Wayne A

    2013-01-01

    This work demonstrates that simulations of advanced burning plasma operation scenarios can be successfully parallelized in time using the parareal algorithm. CORSICA - an advanced operation scenario code for tokamak plasmas is used as a test case. This is a unique application since the parareal algorithm has so far been applied to relatively much simpler systems except for the case of turbulence. In the present application, a computational gain of an order of magnitude has been achieved which is extremely promising. A successful implementation of the Parareal algorithm to codes like CORSICA ushers in the possibility of time efficient simulations of ITER plasmas.

  13. Near real-time imaging of molasses injections using time-lapse electrical geophysics at the Brandywine DRMO, Brandywine, Maryland

    NASA Astrophysics Data System (ADS)

    Versteeg, R. J.; Johnson, T.; Major, B.; Day-Lewis, F. D.; Lane, J. W.

    2010-12-01

    Enhanced bioremediation, which involves introduction of amendments to promote biodegradation, increasingly is used to accelerate cleanup of recalcitrant compounds and has been identified as the preferred remedial treatment at many contaminated sites. Although blind introduction of amendments can lead to sub-optimal or ineffective remediation, the distribution of amendment throughout the treatment zone is difficult to measure using conventional sampling. Because amendments and their degradation products commonly have electrical properties that differ from those of ambient soil, time-lapse electrical geophysical monitoring has the potential to verify amendment emplacement and distribution. In order for geophysical monitoring to be useful, however, results of the injection ideally should be accessible in near real time. In August 2010, we demonstrated the feasibility of near real-time, autonomous electrical geophysical monitoring of amendment injections at the former Defense Reutilization and Marketing Office (DRMO) in Brandywine, Maryland. Two injections of about 1000 gallons each of molasses, a widely used amendment for enhanced bioremediation, were monitored using measurements taken with borehole and surface electrodes. During the injections, multi-channel resistance data were recorded; data were transmitted to a server and processed using a parallel resistivity inversion code; and results in the form of time-lapse imagery subsequently were posted to a website. This process occurred automatically without human intervention. The resulting time-lapse imagery clearly showed the evolution of the molasses plume. The delay between measurements and online delivery of images was between 45 and 60 minutes, thus providing actionable information that could support decisions about field procedures and a check on whether amendment reached target zones. This experiment demonstrates the feasibility of using electrical imaging as a monitoring tool both during amendment emplacement

  14. Time-lapse VSP data processing for monitoring CO2 injection

    SciTech Connect

    Huang, Lianjie; Rutledge, James; Cheng, Arthur

    2009-01-01

    As a part of the effort of the Southwest Regional Partnership on Carbon Sequestration supported by U.S. Department of Energy and managed by the National Energy Technology Laboratory, two sets of time-lapse VSPs were acquired and processed in oil fields undergoing CO{sub 2} injection. One set of VSPs was acquired at the Aneth oil field in Utah, the other set at the Scurry Area Canyon Reef Operators Committee (SACROC) field in West Texas. One baseline and two repeat VSP surveys were conducted from 2007 to 2009 at the Aneth oil field in Utah for monitoring CO{sub 2} injection. The aim of the time-lapse VSP surveys is to study the combined enhanced oil recovery (EOR) and CO{sub 2} sequestration in collaboration with Resolute Natural Resources, Inc. VSP data were acquired using a cemented geophone string with 60 levels at depth from 805 m to 1704 m, and CO{sub 2} is injected into a horizontal well nearby within the reservoir at depth approximately from 1730 m to 1780 m. For each VSP survey, the data were acquired for one zero-offset source location and seven offset source locations (Figure 1). The baseline VSP survey was conducted before the CO{sub 2} injection. More than ten thousand tons of CO{sub 2} was injected between each of the two repeat VSP surveys. There are three horizontal injection wells, all originating from the same vertical well. One is drilled towards Southeast, directly towards the monitoring well (Figure 2), and the other two towards Northwest, directly away from the monitoring well. The injection is into the top portion of the Desert Creek formation, just beneath the Gothic shale, which acts as the reservoir seal. The initial baseline acquisition was done in October 2007; subsequent time-lapse acquisitions were conducted in July 2008, and January 2009. The acquisition geometry is shown in Figure 1. Shot point 1 is the zero-offset source location, Shot points 2 to 8 are the seven offset VSPs, arranged in a quarter circle on the Northwest side of the

  15. A biomechanical model for real-time simulation of PMMA injection with haptics.

    PubMed

    Lian, Z; Chui, C-K; Teoh, S-H

    2008-03-01

    We have developed a computationally efficient rheological model to simulate polymethylmethacrylate (PMMA) injection into cancellous bone during percutaneous vertebroplasty. The model employs the Hagen-Poiseuille law to predict pressure drop across a delivery cannula with viscoelastic changes of curing PMMA modeled via a time and shear-rate-dependent power law. The power law was derived based on dynamic rheological testing of curing PMMA samples. In conjunction with a branching-pipe geometrical model that is reconstructed from micro-computed tomography scans of cancellous bone for estimating pressure changes during PMMA flow in bone, the method provides a fast estimation of overall injection pressure, and, hence, the reaction force during manual PMMA injection.

  16. Modeling Injection Induced Seismicity with Poro-Elasticity and Time-Dependent Earthquake Nucleation

    NASA Astrophysics Data System (ADS)

    Lu, S.; Segall, P.

    2014-12-01

    The standard approach to modeling injection-induced seismicity (IIS) considers Coulomb failure stress changes accounting only for pore-pressure changes, which are solved by the diffusion equation. However, this "diffusion" triggering mechanism is not comprehensive. Lab experiments indicate earthquake nucleation also depends on stress history. Here we add two effects in modeling IIS: 1) poro-elastic coupling between solid stresses and pore-pressure, and 2) time dependent earthquake nucleation under applied stresses. In this model, we compute stress and pore-pressure changes due to a point source injecting in a homogeneous, poro-elastic full space (Rudnicki, 1986). The Coulomb stress history is used to compute seismicity rate changes based on the time-dependent nucleation model of Dieterich (1994). Our new model reveals: 1) poro-elastic coupling breaks the radial symmetry in seismicity, 2) nucleation introduces a characteristic nucleation time ta, which affects the temporal evolution of seismicity rates, and 3) for some fault geometries, the seismicity rate may increase following shut in. For constant injection flux, the log of seismicity rate scales with the change in Coulomb stress at short time, consistent with diffusion profiles. At longer time, the model predicts seismicity rates decaying with time, consistent with some observations. The contour shape and decay time are characterized by ta. For finite injection with box-car flux history, seismicity rates plummet near the injector, but may continue for some time at greater distance. Depending on fault orientations, seismicity rates may increase after shut-in due to coupling effects. It has been observed in some cases that the maximum magnitude of induced quakes occurs after shut-in. This may be understood by the fact that the volume of perturbed crust increases with injection time, which influences probability of triggering an event of a given magnitude. Whether coupling effects are important in post shut

  17. Advanced Optical Diagnostic Methods for Describing Fuel Injection and Combustion Flowfield Phenomena

    NASA Technical Reports Server (NTRS)

    Locke, Randy J.; Hicks, Yolanda R.; Anderson, Robert C.

    2004-01-01

    Over the past decade advanced optical diagnostic techniques have evolved and matured to a point where they are now widely applied in the interrogation of high pressure combusting flows. At NASA Glenn Research Center (GRC), imaging techniques have been used successfully in on-going work to develop the next generation of commercial aircraft gas turbine combustors. This work has centered on providing a means by which researchers and designers can obtain direct visual observation and measurements of the fuel injection/mixing/combustion processes and combustor flowfield in two- and three-dimensional views at actual operational conditions. Obtaining a thorough understanding of the chemical and physical processes at the extreme operating conditions of the next generation of combustors is critical to reducing emissions and increasing fuel efficiency. To accomplish this and other tasks, the diagnostic team at GRC has designed and constructed optically accessible, high pressurer high temperature flame tubes and sectar rigs capable of optically probing the 20-60 atm flowfields of these aero-combustors. Among the techniques employed at GRC are planar laser-induced fluorescence (PLIF) for imaging molecular species as well as liquid and gaseous fuel; planar light scattering (PLS) for imaging fuel sprays and droplets; and spontaneous Raman scattering for species and temperature measurement. Using these techniques, optical measurements never before possible have been made in the actual environments of liquid fueled gas turbines. 2-D mapping of such parameters as species (e.g. OH-, NO and kerosene-based jet fuel) distribution, injector spray angle, and fuel/air distribution are just some of the measurements that are now routinely made. Optical imaging has also provided prompt feedback to researchers regarding the effects of changes in the fuel injector configuration on both combustor performance and flowfield character. Several injector design modifications and improvements have

  18. Extension of time until cardiac arrest after injection of a lethal dose of pentobarbital in the hibernating Syrian hamster.

    PubMed

    Miyazawa, Seiji; Shiina, Takahiko; Takewaki, Tadashi; Shimizu, Yasutake

    2009-03-01

    The aim of the present study was to examine whether entry of peripherally injected drugs into the central nervous system is reduced during hibernation. When a lethal dose of pentobarbital was injected intraperitoneally, the time until cardiac arrest was significantly longer in hibernating hamsters than in active controls. The time difference was not a consequence of low body temperature or diminished circulation, because mimicking these parameters in artificial hypothermia did not prolong the time. In contrast, there was no difference in the time until cardiac arrest after intracerebroventricular injection of the anesthetic. These results indicate that entry of peripherally injected anesthetics into the central nervous system may be suppressed during hibernation.

  19. Tunnel injection transit-time diodes for W-band power generation

    NASA Technical Reports Server (NTRS)

    Kidner, C.; Eisele, H.; Haddad, G. I.

    1992-01-01

    GaAs p(+ +)n(+)n(-)n(+) single-drift tunnel injection transit-time (TUNNETT) diodes for W-band operation have been successfully designed and tested. An output power of 32 mW at 93.5 GHz with a dc to RF conversion efficiency of 2.6 percent was obtained. The oscillations have a clean spectrum in a conventional waveguide cavity.

  20. Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction.

    PubMed

    Blackburn, Nick J R; Sofrenovic, Tanja; Kuraitis, Drew; Ahmadi, Ali; McNeill, Brian; Deng, Chao; Rayner, Katey J; Zhong, Zhiyuan; Ruel, Marc; Suuronen, Erik J

    2015-01-01

    Injectable hydrogel biomaterials are promising therapies to promote repair and regeneration post-myocardial infarction (MI). However, the timing of delivery and the mechanisms through which biomaterial treatments confer their benefits are translational issues that remain to be addressed. We assessed the efficacy of an injectable collagen matrix at 3 different delivery time points post-MI. Infarcted mice received the matrix or control (saline) treatment at 3 h, 1 week or 2 weeks after MI. The earlier treatment delivery better prevented negative ventricular remodeling and long-term deterioration of cardiac function (up to 3 months), whereas waiting longer to administer the matrix (1 and 2 weeks post-MI) reduced the therapeutic effects. Collagen matrix delivery did not stimulate an inflammatory response acutely and favorably modulated inflammation in the myocardium long-term. We found that the matrix interacts with the host tissue to alter the myocardial cytokine profile, promote angiogenesis, and reduce fibrosis and cell death. This work highlights that the timing of delivery can significantly affect the ability of an injectable hydrogel to protect the post-MI environment, which will be an important consideration in the clinical translation of cardiac biomaterial therapy.

  1. Estimation of Injected Carbon Longevity and Re-oxidation Times at Enhanced Reductive Bioremediation Sites

    NASA Astrophysics Data System (ADS)

    Tillotson, J.; Borden, R. C.

    2014-12-01

    Addition of an organic substrate to provide an electron donor and carbon source can be very effective at stimulating enhanced reductive bioremediation (ERB) of chlorinated solvents, energetics, and other groundwater contaminants. However, the quantity of electron donor added is usually based on an individual's or company's "rule of thumb" rather than considering site-specific conditions such as groundwater velocity, carbon source, and upgradient electron acceptor concentrations, potentially leading to unnecessarily large amounts of carbon injected. Mass balance estimates indicate that over 99% of electrons donated go to electron acceptors other than the primary contaminants. Thus, injecting excessive amounts of organic carbon can lead to a persistent reducing zone, releasing elevated levels of dissolved manganese, iron, methane, and sometimes arsenic. Monitoring data on carbon injections and electron acceptors were collected from 33 ERB sites. Two approaches were then used to evaluate carbon longevity and the time required to return to near-oxic conditions at an ERB site. The first method employed a simple mass balance approach, using such input parameters as groundwater velocity, upgradient electron acceptors, and amount of carbon injected. In the second approach, a combined flow, transport and geochemical model was developed using PHT3D to estimate the impact of ERB on secondary water quality impacts (SWQIs; e.g., methane production, iron mobilization and transport, etc.) The model was originally developed for use in estimating SWQIs released from petroleum sites, but has since been modified for use at ERB sites. The ERB site to be studied is a perchlorate release site in Elkton, Maryland where 840 lbs of an emulsified vegetable oil was injected. The results from the simple mass balance approach and PHT3D model will be compared and used to identify conditions where the simplified approach may be appropriate.

  2. Least-squares reverse-time migration of Cranfield VSP data for monitoring CO2 injection

    NASA Astrophysics Data System (ADS)

    TAN, S.; Huang, L.

    2012-12-01

    Cost-effective monitoring for carbon utilization and sequestration requires high-resolution imaging with a minimal amount of data. Least-squares reverse-time migration is a promising imaging method for this purpose. We apply least-squares reverse-time migration to a portion of the 3D vertical seismic profile data acquired at the Cranfield enhanced oil recovery field in Mississippi for monitoring CO2 injection. Conventional reverse-time migration of limited data suffers from significant image artifacts and a poor image resolution. Lease-squares reverse-time migration can reduce image artifacts and improves the image resolution. We demonstrate the significant improvements of least-squares reverse-time migration by comparing its migration images of the Cranfield VSP data with that obtained using the conventional reverse-time migration.

  3. Source Repeatability of Time-Lapse Offset VSP Surveys for Monitoring CO2 Injection

    NASA Astrophysics Data System (ADS)

    Zhang, Z.; Huang, L.; Rutledge, J. T.; Denli, H.; Zhang, H.; McPherson, B. J.; Grigg, R.

    2009-12-01

    Time-lapse vertical seismic profiling (VSP) surveys have the potential to remotely track the migration of injected CO2 within a geologic formation. To accurately detect small changes due to CO2 injection, the sources of time-lapse VSP surveys must be located exactly at the same positions. However, in practice, the source locations can vary from one survey to another survey. Our numerical simulations demonstrate that a variation of a few meters in the VSP source locations can result in significant changes in time-lapse seismograms. To address the source repeatability issue, we apply double-difference tomography to downgoing waves of time-lapse offset VSP data to invert for the source locations and the velocity structures simultaneously. In collaboration with Resolute Natural Resources, Navajo National Oil and Gas Company, and the Southwest Regional Partnership on Carbon Sequestration under the support of the U.S. Department of Energy’s National Energy Technology Laboratory, one baseline and two repeat offset VSP datasets were acquired in 2007-2009 for monitoring CO2 injection at the Aneth oil field in Utah. A cemented geophone string was used to acquire the data for one zero-offset and seven offset source locations. During the data acquisition, there was some uncertainty in the repeatability of the source locations relative to the baseline survey. Our double-difference tomography results of the Aneth time-lapse VSP data show that the source locations for different surveys are separated up to a few meters. Accounting for these source location variations during VSP data analysis will improve reliability of time-lapse VSP monitoring.

  4. Real-time rendering of drug injection and interactive simulation of vessel deformation using GPU.

    PubMed

    Wu, Jichuan; Chui, Chee Kong; Binh, P Nguyen; Teo, Chee Leong

    2013-01-01

    Developing patient specific model for the simulation of chemotherapy drug injection is important in medical application. This paper proposed a two-phase fluidic method to simulate chemotherapy drug injection and an improved lumped element method to simulate deformation of vessel at real-time by using GPU for general computing. Firstly, a three-dimensional (3-D) model of hepatic vessels is reconstructed from clinical CT-images using multi-layer method. A 3-D thinning algorithm based on Valence Driven Spatial Median (VDSM) is applied to generate unit-width skeleton of the vessel tree. The two-phase flow simulation of drug injection is based on Hagen-Poiseuille model by introducing a friction factor using bubbly flow Reynolds number. The improved lumped element method achieves good simulation realism at high computational speed to simulate deformable object. Real-time rendering and interaction of vessel deformation, self collision, and surface tearing has been realized and demonstrated in a virtual experiment.

  5. Optimal contant time injection policy for enhanced oil recovery and characterization of optimal viscous profiles

    NASA Astrophysics Data System (ADS)

    Daripa, Prabir

    2011-11-01

    We numerically investigate the optimal viscous profile in constant time injection policy of enhanced oil recovery. In particular, we investigate the effect of a combination of interfacial and layer instabilities in three-layer porous media flow on the overall growth of instabilities and thereby characterize the optimal viscous profile. Results based on monotonic and non-monotonic viscous profiles will be presented. Time permitting. we will also present results on multi-layer porous media flows for Newtonian and non-Newtonian fluids and compare the results. The support of Qatar National Fund under a QNRF Grant is acknowledged.

  6. Time Varying Apparent Volume of Distribution and Drug Half-Lives Following Intravenous Bolus Injections

    PubMed Central

    Wesolowski, Carl A.; Wesolowski, Michal J.; Babyn, Paul S.

    2016-01-01

    We present a model that generalizes the apparent volume of distribution and half-life as functions of time following intravenous bolus injection. This generalized model defines a time varying apparent volume of drug distribution. The half-lives of drug remaining in the body vary in time and become longer as time elapses, eventually converging to the terminal half-life. Two example fit models were substituted into the general model: biexponential models from the least relative concentration error, and gamma variate models using adaptive regularization for least relative error of clearance. Using adult population parameters from 41 studies of the renal glomerular filtration marker 169Yb-DTPA, simulations of extracellular fluid volumes of 5, 10, 15 and 20 litres and plasma clearances of 40 and 100 ml/min were obtained. Of these models, the adaptively obtained gamma variate models had longer times to 95% of terminal volume and longer half-lives. PMID:27403663

  7. Experimental Studies of Diestrol-Micro Emulsion Fuel in a Direct Injection Compression Ignition Engine under Varying Injection Pressures and Timings

    NASA Astrophysics Data System (ADS)

    Kannan, Gopal Radhakrishnan

    2017-03-01

    The research work on biodiesel becomes more attractive in the context of limited availability of petroleum fuels and rapid increase of harmful emissions from diesel engine using conventional fossil fuels. The present investigation has dealt with the influence of biodiesel-diesel-ethanol (diestrol) water micro emulsion fuel (B60D20E20M) on the performance, emission and combustion characteristics of a diesel engine under different injection pressure and timing. The results revealed that the maximum brake thermal efficiency of 32.4% was observed at an injection pressure of 260 bar and injection timing of 25.5°bTDC. In comparison with diesel, micro emulsion fuel showed reduction in carbon monoxide (CO) and total hydrocarbon (THC) by 40 and 24%, respectively. Further, micro emulsion fuel decreased nitric oxide (NO) emission and smoke emission by 7 and 20.7%, while the carbon dioxide (CO2) emission is similar to that of diesel.

  8. Evaluation of bisphenol E cyanate ester for the resin-injection repair of advanced composites

    SciTech Connect

    Lio, Wilber Yaote

    2009-12-01

    This thesis is a compilation of a general introduction and literature review that ties together the subsequent chapters which consist of two journal articles that have yet to be submitted for publication. The overall topic relates to the evaluation and application of a new class of cyanate ester resin with unique properties that lend it applicable to use as a resin for injection repair of high glass transition temperature polymer matrix composites. The first article (Chapter 2) details the evaluation and optimization of adhesive properties of this cyanate ester and alumina nanocomposites under different conditions. The second article (Chapter 3) describes the development and evaluation of an injection repair system for repairing delaminations in polymer matrix composites.

  9. Real-Time Variation of the Injected Neutral Beam Energy on the DIII-D Tokamak

    NASA Astrophysics Data System (ADS)

    Scoville, J. T.; Crowley, B. J.; Pace, D. C.; Rauch, J. M.

    2016-10-01

    A powerful new technique for smoothly controlling the time evolution of injected energy from neutral beams has recently been implemented on the DIII-D tokamak. Upgrades to the high voltage circuitry of the neutral beams and to the tokamak's Plasma Control System have enabled the first-ever continuous variation of beam voltage during plasma shots. This avoids the perturbative effects of pulse modulation, which was the previously employed method for changing the injected beam power. The new technique allows much finer control of the injected energy, with beam voltage able to be varied smoothly over a 20 kV range (within the 45-85 kV beam operating space) in 0.5 sec. This capability enables fundamentally new experiments that require precise control of beam ion phase space, including the minimization of undesirable energetic ion instabilities and scans across low torque regimes at fixed power. We present a description of the beam system modifications and initial results from plasma experiments using the new variable beam energy capability on the DIII-D tokamak. Work supported by U.S. DOE under DE-FC02-04ER54698.

  10. Simulation of Electron Cloud Density Distributions in RHIC Dipoles at Injection and Transition and Estimates for Scrubbing Times

    SciTech Connect

    He,P.; Blaskiewicz, M.; Fischer, W.

    2009-01-02

    In this report we summarize electron-cloud simulations for the RHIC dipole regions at injection and transition to estimate if scrubbing over practical time scales at injection would reduce the electron cloud density at transition to significantly lower values. The lower electron cloud density at transition will allow for an increase in the ion intensity.

  11. Design of the Advanced Light Source timing system

    SciTech Connect

    Fahmie, M.

    1993-05-01

    The Advanced Light Source (ALS) is a third generation synchrotron radiation facility, and as such, has several unique timing requirements. Arbitrary Storage Ring filling patterns and high single bunch purity requirements demand a highly stable, low jitter timing system with the flexibility to reconfigure on a pulse-to-pulse basis. This modular system utilizes a highly linear Gauss Clock with ``on the fly`` programmable setpoints to track a free-running Booster ramping magnet and provides digitally programmable sequencing and delay for Electron Gun, Linac, Booster Ring, and Storage Ring RF, Pulsed Magnet, and Instrumentation systems. It has proven itself over the last year of accelerator operation to be reliable and rock solid.

  12. Simulating the effects of timing and energy stability in a laser wakefield accelerator with external injection

    SciTech Connect

    Dijk, W. van; Corstens, J. M.; Stragier, X. F. D.; Brussaard, G. J. H.; Geer, S. B. van der

    2009-01-22

    One of the most compelling reasons to use external injection of electrons into a laser wakefield accelerator is to improve the stability and reproducibility of the accelerated electrons. We have built a simulation tool based on particle tracking to investigate the expected output parameters. Specifically, we are simulating the variations in energy and bunch charge under the influence of variations in laser power and timing jitter. In these simulations a a{sub 0} = 0.32 to a{sub 0} = 1.02 laser pulse with 10% shot-to-shot energy fluctuation is focused into a plasma waveguide with a density of 1.0x10{sup 24} m{sup -3} and a calculated matched spot size of 50.2 {mu}m. The timing of the injected electron bunch with respect to the laser pulse is varied from up to 1 ps from the standard timing (1 ps ahead or behind the laser pulse, depending on the regime). The simulation method and first results will be presented. Shortcomings and possible extensions to the model will be discussed.

  13. Time-Dependent Properties of Multimodal Polyoxymethylene Based Binder for Powder Injection Molding

    NASA Astrophysics Data System (ADS)

    Gonzalez-Gutierrez, Joamin; Stringari, Gustavo Beulke; Zupancic, Barbara; Kubyshkina, Galina; Bernstorff, Bernd Von; Emri, Igor

    Powder injection molding (PIM) is one of the most versatile methods for the manufacturing of small complex shaped components from metal, ceramic or cemented carbide powders for the use in many applications. PIM consists of mixing the powder and a polymeric binder, injecting this mixture in a mold, debinding and then sintering. Catalytic debinding of polyoxymethylene (POM) is attractive since it shows high debinding rates and low risk of cracking. This work examines the possibility of using POM with bimodal molecular mass distribution as the main component of the binding agent by studying its time-dependent properties and comparing them to monomodal POM. Furthermore, possible optimization of the binder formulation was investigated by the addition of shorter polymeric chains (wax) to bimodal POM, as to create a multimodal material. It was observed that the magnitude of the complex viscosity for the commercial bimodal material was more than 2 times lower than for the chemically identical monomodal POM within the investigated frequency range and temperature. Viscosity values were observed to drop as the content of wax was increased, without compromising the binders mechanical properties in solid state. A new formulation of bimodal POM plus 8 wt.% of added wax provided the most appropriate results from investigated combinations. This work has shown how the addition of short polymeric chains in POM influences its time-dependent properties in solid and molten state, which can be an important tool for the optimization of binders designed to be used in PIM technology.

  14. Time-Lapse Electrical Resistivity Investigations for Imaging the Grouting Injection in Shallow Subsurface Cavities

    PubMed Central

    Farooq, Muhammad; Kim, Jung Ho; Song, Young Soo; Amjad Sabir, Mohammad; Umar, Muhammad; Tariq, Mohammad; Muhammad, Said

    2014-01-01

    The highway of Yongweol-ri, Muan-gun, south-western part of the South Korean Peninsula, is underlain by the abandoned of subsurface cavities, which were discovered in 2005. These cavities lie at shallow depths with the range of 5∼15 meters below the ground surface. Numerous subsidence events have repeatedly occurred in the past few years, damaging infrastructure and highway. As a result of continuing subsidence issues, the Korean Institute of Geosciences and Mineral Resources (KIGAM) was requested by local administration to resolve the issue. The KIGAM used geophysical methods to delineate subsurface cavities and improve more refined understanding of the cavities network in the study area. Cement based grouting has been widely employed in the construction industry to reinforce subsurface ground. In this research work, time-lapse electrical resistivity surveys were accomplished to monitor the grouting injection in the subsurface cavities beneath the highway, which have provided a quasi-real-time monitoring for modifying the subsurface cavities related to ground reinforcement, which would be difficult with direct methods. The results obtained from time-lapse electrical resistivity technique have satisfactory imaged the grouting injection experiment in the subsurface cavities beneath the highway. Furthermore, the borehole camera confirmed the presence of grouting material in the subsurface cavities, and hence this procedure increases the mechanical resistance of subsurface cavities below the highway. PMID:24578621

  15. Time-lapse electrical resistivity investigations for imaging the grouting injection in shallow subsurface cavities.

    PubMed

    Farooq, Muhammad; Park, Samgyu; Kim, Jung Ho; Song, Young Soo; Amjad Sabir, Mohammad; Umar, Muhammad; Tariq, Mohammad; Muhammad, Said

    2014-01-01

    The highway of Yongweol-ri, Muan-gun, south-western part of the South Korean Peninsula, is underlain by the abandoned of subsurface cavities, which were discovered in 2005. These cavities lie at shallow depths with the range of 5∼15 meters below the ground surface. Numerous subsidence events have repeatedly occurred in the past few years, damaging infrastructure and highway. As a result of continuing subsidence issues, the Korean Institute of Geosciences and Mineral Resources (KIGAM) was requested by local administration to resolve the issue. The KIGAM used geophysical methods to delineate subsurface cavities and improve more refined understanding of the cavities network in the study area. Cement based grouting has been widely employed in the construction industry to reinforce subsurface ground. In this research work, time-lapse electrical resistivity surveys were accomplished to monitor the grouting injection in the subsurface cavities beneath the highway, which have provided a quasi-real-time monitoring for modifying the subsurface cavities related to ground reinforcement, which would be difficult with direct methods. The results obtained from time-lapse electrical resistivity technique have satisfactory imaged the grouting injection experiment in the subsurface cavities beneath the highway. Furthermore, the borehole camera confirmed the presence of grouting material in the subsurface cavities, and hence this procedure increases the mechanical resistance of subsurface cavities below the highway.

  16. Influence of fuel injection timing and pressure on in-flame soot particles in an automotive-size diesel engine.

    PubMed

    Zhang, Renlin; Kook, Sanghoon

    2014-07-15

    The current understanding of soot particle morphology in diesel engines and their dependency on the fuel injection timing and pressure is limited to those sampled from the exhaust. In this study, a thermophoretic sampling and subsequent transmission electron microscope imaging were applied to the in-flame soot particles inside the cylinder of a working diesel engine for various fuel injection timings and pressures. The results show that the number count of soot particles per image decreases by more than 80% when the injection timing is retarded from -12 to -2 crank angle degrees after the top dead center. The late injection also results in over 90% reduction of the projection area of soot particles on the TEM image and the size of soot aggregates also become smaller. The primary particle size, however, is found to be insensitive to the variations in fuel injection timing. For injection pressure variations, both the size of primary particles and soot aggregates are found to decrease with increasing injection pressure, demonstrating the benefits of high injection velocity and momentum. Detailed analysis shows that the number count of soot particles per image increases with increasing injection pressure up to 130 MPa, primarily due to the increased small particle aggregates that are less than 40 nm in the radius of gyration. The fractal dimension shows an overall decrease with the increasing injection pressure. However, there is a case that the fractal dimension shows an unexpected increase between 100 and 130 MPa injection pressure. It is because the small aggregates with more compact and agglomerated structures outnumber the large aggregates with more stretched chain-like structures.

  17. Mitoxantrone Injection

    MedlinePlus

    ... medications to relieve pain in people with advanced prostate cancer who did not respond to other medications. Mitoxantrone ... doses). When mitoxantrone injection is used to treat prostate cancer, it is usually given once every 21 days. ...

  18. Flow excursion time scales in the advanced neutron source reactor

    SciTech Connect

    Sulfredge, C.D.

    1995-04-01

    Flow excursion transients give rise to a key thermal limit for the proposed Advanced Neutron Source (ANS) reactor because its core involves many parallel flow channels with a common pressure drop. Since one can envision certain accident scenarios in which the thermal limits set by flow excursion correlations might be exceeded for brief intervals, a key objective is to determine how long a flow excursion would take to bring about a system failure that could lead to fuel damage. The anticipated time scale for flow excursions has been examined by subdividing the process into its component phenomena: bubble nucleation and growth, deceleration of the resulting two-phase flow, and finally overcoming thermal inertia to heat up the reactor fuel plates. Models were developed to estimate the time required for each individual stage. Accident scenarios involving sudden reduction in core flow or core exit pressure have been examined, and the models compared with RELAP5 output for the ANS geometry. For a high-performance reactor like the ANS, flow excursion time scales were predicted to be in the millisecond range, so that even very brief transients might lead to fuel damage. These results should prove useful whenever one must determine the time involved in any portion of a flow excursion transient.

  19. Locally advanced rectal cancer: time for precision therapeutics.

    PubMed

    Weiser, Martin R; Zhang, Zhen; Schrag, Deborah

    2015-01-01

    The year 2015 marks the 30th anniversary of the publication of NSABP-R01, a landmark trial demonstrating the benefit of adding pelvic radiation to the treatment regimen for locally advanced rectal cancer with a resultant decrease in local recurrence from 25% to 16%. These results ushered in the era of multimodal therapy for rectal cancer, heralding modern treatment and changing the standard of care in the United States. We have seen many advances over the past 3 decades, including optimization of the administration and timing of radiation, widespread adoption of total mesorectal excision (TME), and the implementation of more effective systemic chemotherapy. The current standard is neoadjuvant chemoradiation with 5-fluorouracil (5-FU) and a radiosensitizer, TME, and adjuvant chemotherapy including 5-FU and oxaliplatin. The results of this regimen have been impressive, with a reported local recurrence rate of less than 10%. However, the rates of distant relapse remain 30% to 40%, indicating room for improvement. In addition, trimodality therapy is arduous and many patients are unable to complete the full course of treatment. In this article we discuss the current standard of care and alternative strategies that have evolved in an attempt to individualize therapy according to risk of recurrence.

  20. Time Savings with Rituximab Subcutaneous Injection versus Rituximab Intravenous Infusion: A Time and Motion Study in Eight Countries

    PubMed Central

    De Cock, Erwin; Kritikou, Persefoni; Sandoval, Mariana; Tao, Sunning; Wiesner, Christof; Carella, Angelo Michele; Ngoh, Charles; Waterboer, Tim

    2016-01-01

    Background Rituximab is a standard treatment for non-Hodgkin lymphoma. The SABRINA trial (NCT01200758) showed that a subcutaneous (SC) rituximab formulation did not compromise efficacy or safety compared with intravenous (IV) infusion. We aimed to quantify active healthcare professional (HCP) time and patient chair time for rituximab SC and IV, including potential time savings. Methods This non-interventional time and motion study was run in eight countries and 30 day oncology units. Rituximab SC data were collected alongside the MabCute trial (NCT01461928); IV data were collected per routine real-world practice. Trained observers recorded active HCP time for pre-specified tasks (stopwatch) and chair time (time of day). A random intercept model was used to analyze active HCP time (by task and for all tasks combined) in the treatment room and drug preparation area, drug administration duration, chair time and patient treatment room time by country and/or across countries. Active HCP and chair time were extrapolated to a patient’s first year of treatment (11 rituximab sessions). Results Mean active HCP time was 35.0 and 23.7 minutes for IV and SC process, respectively (-32%, p <0.0001). By country, relative reduction in time was 27–58%. Absolute reduction in extrapolated active HCP time (first year of treatment) was 1.1–5.2 hours. Mean chair time was 262.1 minutes for IV, including 180.9 minutes infusion duration, vs. 67.3 minutes for SC, including 8.3 minutes SC injection administration (-74%, p <0.0001). By country, relative reduction was 53–91%. Absolute reduction in extrapolated chair time for the first year of treatment was 3.1–5.5 eight-hour days. Conclusions Compared with rituximab IV, rituximab SC was associated with reduced chair time and active HCP time. The latter could be invested in other activities, whereas the former may lead to more available appointments, reducing waiting lists and increasing the efficiency of day oncology units. Trial

  1. Migration rates and formation injectivity to determine containment time scales of sequestered carbon dioxide

    USGS Publications Warehouse

    Burke, Lauri

    2012-01-01

    Additionally, this research establishes a methodology to calculate the injectivity of a target formation. Because injectivity describes the pressure increase due to the introduction of fluids into a formation, the relevant application of injectivity is to determine the pressure increase, due to an injection volume and flow rate, that will induce fractures in the reservoir rocks. This quantity is defined mathematically as the maximum pressure differential between the hydrostatic gradient and the fracture gradient of the target formation. Injectivity is mathematically related to the maximum pressure differential of the formation, and can be used to determine the upper limit for the pressure increase that an injection target can withstand before fracturing.

  2. Time-dependent image changes after ethanol injection into the pancreas: an experimental study using a porcine model

    PubMed Central

    Matsumoto, Kazuyuki; Kato, Hironari; Tsutsumi, Koichiro; Fushimi, Soichiro; Iwamuro, Masaya; Oda, Shinsuke; Mizukawa, Sho; Akimoto, Yutaka; Uchida, Daisuke; Tomoda, Takeshi; Yamamoto, Naoki; Horiguchi, Shigeru; Okada, Hiroyuki

    2016-01-01

    Background Ethanol, a commonly available agent, has been used to successfully ablate cystic and solid lesions in the pancreas. The aim of this study is to investigate the effects of an ethanol injection into the porcine pancreas and observe the time-dependent image changes in the pancreatic parenchyma. Methods Pure ethanol was injected into the pancreatic tail using a 25-gauge EUS needle with direct ultrasound guidance under celiotomy: 1 mL and 2 mL were injected, respectively. The abdomen was closed after the injection. MRI was performed before the procedure, immediately after, and on postoperative day (POD) seven. Blood samples were taken before the procedure and on PODs one, three, five, and seven. The pigs were euthanised on POD seven. Results Immediately after the injection, linear high signal areas in the pancreatic tail on T2 and rounded speckled high signal areas on DWI images were detected in both animals, measuring 35 × 32 mm in the 1 mL injected pig and 42 × 38mm in the 2 mL injected pig. After POD seven, rounded high signal areas were noted on T2 images, measuring 22 × 18 mm and 36 × 28 mm respectively. On POD one, the 1 mL injected animal had a 53% elevation in serum amylase while the 2 mL injected animal had a 66% elevation. Histologically, cystic and necrotic changes in the parenchyma were observed, measuring 23 × 22 mm and 40 × 35 mm respectively. Conclusions Our results, which are limited to normal pancreas, suggested that a 1 mL injection caused localised changes within the pancreas while a 2 mL injection induced more widespread changes beyond the pancreas. The effective area of ethanol was widespread immediately after injection, and then the area was reduced with cystic and necrosis changes. PMID:27594908

  3. Investigation of performances of innovative aeronautic injection systems using advanced laser diagnostics

    NASA Astrophysics Data System (ADS)

    Orain, M.; Grisch, F.; Jourdanneau, E.; Rossow, B.; Guin, C.; Trétout, B.

    2011-10-01

    Simultaneous measurements of Planar Laser-Induced Fluorescence (PLIF) kerosene and PLIF-OH have been successfully performed in a multipoint injection system for various overall equivalence ratios, air inlet temperatures between 480 and 730 K, and pressures up to 2.2 MPa. Single-shot two-dimensional (2D) maps of the spatial distribution of kerosene vapor and OH radical in the combustor have been recorded with good signal-to-noise ratio. Results show that depending on the split between the pilot and the main injectors, the flame front exhibits either a single or a double structure. Good spatial correlation between the repartition of kerosene vapor and the position of the flame front was observed; in particular, no "dark zone" is observed between the fuel and the flame front. As temperature and pressure increase, fuel evaporation improves and the spatial distribution of OH radical becomes more homogeneous in the combustor, suggesting a partially-distributed combustion.

  4. Time Lapse Gravity and Seismic Monitoring of CO2 Injection at the West Hastings Field, Texas

    NASA Astrophysics Data System (ADS)

    Ferguson, J. F.; Richards, T.; Klopping, F.; MacQueen, J.; Hosseini, S. A.

    2015-12-01

    Time lapse or 4D gravity and seismic reflection surveys are being conducted at the West Hastings Field near Houston, Texas to monitor the progress of CO2 injection. This Department of Energy supported CO2 sequestration experiment is conducted in conjunction with a Denbury Onshore, LLC tertiary recovery project. The reservoir is at a depth of 1.8 km in the Oligocene Frio sands and has been produced since the 1930s. Goals are an accounting and mapping of the injected CO2 and to determine if migration occurs along intra-reservoir faults. An integrated interpretation of the geophysical surveys will be made together with well logs and engineering data. Gravity monitoring of water versus gas replacement has been very successful, but liquid phase CO2 monitoring is problematic due to the smaller density contrast with respect to oil and water. This reservoir has a small volume to depth ratio and hence only a small gravity difference signal is expected on the surface. New borehole gravity technology introduced by Micro-g-Lacoste can make gravity measurements at near reservoir depths with a much higher signal to noise ratio. This method has been successfully evaluated on a simulation of the Hastings project. Field operations have been conducted for repeated surface and borehole gravity surveys beginning in 2013. The surface survey of 95 stations covers an area of 3 by 5 km and 22 borehole gravity logs are run in the interval above the Frio formation. 4D seismic reflection surveys are being made at 6 month intervals on the surface and in 3 VSP wells. CO2 injection into the targeted portion of the reservoir only began in early 2015 and monitoring will continue into 2017. To date only the baseline reservoir conditions have been assessed. The overall success of the gravity monitoring will not be determined until 2017.

  5. Advanced X-Ray Timing Array (AXTAR) Animation

    NASA Technical Reports Server (NTRS)

    Hopkins, Randall C.; Thompson, Kevin S.

    2011-01-01

    The animation depicts NASA's concept for a next-generation Advanced X-ray Timing Mission. The models and their textures doe not necessarily represent the final iteration. Delivery specifications include launch with Taurus II or Falcon 9, mass of 2650 kg, with a circular low earth orbit at approximately 600 km. The inclination depends on the launch vehicle and spacecraft mass. AXTAR's prime instrument will probe the physics of neutron stars and black holes through X-ray timing and spectral measurements. The primary instrument will be the Large Area Timing Array (LATA). The Sky Monitor Clusters configuration consists of 27 Sky Monitor cameras th at are grouped in five clusters. This configuration will achieve approximately 85 percent all sky coverage. Spacecraft components include a science bus to house the LATA of supermodules; a spacecraft bus to house components such as propulsion tanks, avionics, and reaction wheels; solar arrays configured from space-qualified GaAs 3-junction cells; star trackers for attitude knowledge; a propulsion system of four pods, each containing one 100 lbf and two 5 lbf engines; a launch vehicle adaptor; and a radiation shield.

  6. Effect of a local, one time, low-dose injection of zoledronic acid on titanium implant osseointegration in ovariectomized rats

    PubMed Central

    Ying, Gao; Bo, Lian; Yanjun, Jiao; Lina, Wu

    2016-01-01

    Introduction Local application of bisphosphonates has been proven to be safer than systemic administration to promote implant fixation. The objective of this study was to introduce such a simple, convenient and efficient method to enhance titanium (Ti) implant osseointegration in ovariectomized (OVX) rats. Material and methods Twenty female Sprague-Dawley rats sequentially underwent bilateral ovariectomy and tibia implantation, and injection of 30 µg/implant zoledronic acid (ZOL) at the site of implantation was performed. At the end of the study, the tibiae, mandibles, femurs and vertebrae were harvested for dual energy X-ray absorptiometry, histology and micro-computed tomography examination. Results Ovariectomized rats showed poor bone density, bone mass and trabecular microstructure. OVX + ZOL rats were characterized by significantly improved peri-implant bone area (1.72-fold), bone contact (2.30-fold), bone mineral density (1.57-fold) and bone mineral content (1.67-fold), as well as moderately increased bone volume to total volume ratio (1.34-fold), percentage osteointegration (1.54-fold), connectivity density (1.45-fold), and trabecular number (1.43-fold), but decreased trabecular separation (57.69%) when compared with the control levels (p < 0.05). No histological signs of jaw osteonecrosis were observed in the rats treated with ZOL, and there was no significant difference between the OVX group and OVX + ZOL group in the bone mass of the mandible, femur and 5th lumbar vertebra (p > 0.05). In addition, the overproduction of osteoporosis-induced advanced glycation end-products (AGEs) was completely prevented by local treatment with 30 µg/implant ZOL. Conclusions A local, one time, low-dose injection of ZOL at the site of implantation is able to promote the osseointegration of Ti implants following postmenopausal osteoporosis, and this action may be partly mediated by inhibition of the osteoporosis-induced AGE overproduction in the bone marrow. PMID:27695483

  7. Advances in Time Estimation Methods for Molecular Data.

    PubMed

    Kumar, Sudhir; Hedges, S Blair

    2016-04-01

    Molecular dating has become central to placing a temporal dimension on the tree of life. Methods for estimating divergence times have been developed for over 50 years, beginning with the proposal of molecular clock in 1962. We categorize the chronological development of these methods into four generations based on the timing of their origin. In the first generation approaches (1960s-1980s), a strict molecular clock was assumed to date divergences. In the second generation approaches (1990s), the equality of evolutionary rates between species was first tested and then a strict molecular clock applied to estimate divergence times. The third generation approaches (since ∼2000) account for differences in evolutionary rates across the tree by using a statistical model, obviating the need to assume a clock or to test the equality of evolutionary rates among species. Bayesian methods in the third generation require a specific or uniform prior on the speciation-process and enable the inclusion of uncertainty in clock calibrations. The fourth generation approaches (since 2012) allow rates to vary from branch to branch, but do not need prior selection of a statistical model to describe the rate variation or the specification of speciation model. With high accuracy, comparable to Bayesian approaches, and speeds that are orders of magnitude faster, fourth generation methods are able to produce reliable timetrees of thousands of species using genome scale data. We found that early time estimates from second generation studies are similar to those of third and fourth generation studies, indicating that methodological advances have not fundamentally altered the timetree of life, but rather have facilitated time estimation by enabling the inclusion of more species. Nonetheless, we feel an urgent need for testing the accuracy and precision of third and fourth generation methods, including their robustness to misspecification of priors in the analysis of large phylogenies and data

  8. Investigation of storm time magnetotail and ion injection using three-dimensional global hybrid simulation

    NASA Astrophysics Data System (ADS)

    Lin, Y.; Wang, X. Y.; Lu, S.; Perez, J. D.; Lu, Q.

    2014-09-01

    Dynamics of the near-Earth magnetotail associated with substorms during a period of extended southward interplanetary magnetic field is studied using a three-dimensional (3-D) global hybrid simulation model that includes both the dayside and nightside magnetosphere, for the first time, with physics from the ion kinetic to the global Alfvénic convection scales. It is found that the dayside reconnection leads to the penetration of the dawn-dusk electric field through the magnetopause and thus a thinning of the plasma sheet, followed by the magnetotail reconnection with 3-D, multiple flux ropes. Ion kinetic physics is found to play important roles in the magnetotail dynamics, which leads to the following results: (1) Hall electric fields in the thin current layer cause a systematic dawnward ion drift motion and thus a dawn-dusk asymmetry of the plasma sheet with a higher (lower) density on the dawnside (duskside). Correspondingly, more reconnection occurs on the duskside. Bidirectional fast ions are generated due to acceleration in reconnection, and more high-speed earthward flow injections are found on the duskside than the dawnside. Such finding of the dawn-dusk asymmetry is consistent with recent satellite observations. (2) The injected ions undergo the magnetic gradient and curvature drift in the dipole-like field, forming a ring current. (3) Ion particle distributions reveal multiple populations/beams at various distances in the tail. (4) Dipolarization of the tail magnetic field takes place due to the pileup of the injected magnetic fluxes and thermal pressure of injected ions, where the fast earthward flow is stopped. Oscillation of the dipolarization front is developed at the fast-flow braking, predominantly on the dawnside. (5) Kinetic compressional wave turbulence is present around the dipolarization front. The cross-tail currents break into small-scale structures with k⟂ρi˜1, where k⟂ is the perpendicular wave number. A sharp dip of magnetic field

  9. Concealment of time delay signature of chaotic output in a slave semiconductor laser with chaos laser injection

    NASA Astrophysics Data System (ADS)

    Wu, Tianan; Sun, Weiyang; Zhang, Xiaoxu; Zhang, Shenghai

    2016-12-01

    An improved chaotic laser system, which has a slave semiconductor laser (SL) injected by a master SL with double optical feedback (DOF), is proposed, so that the time delay (TD) signature can be successfully concealed from both intensity and phase chaos via choosing appropriate parameters. The TD signature is investigated by employing autocorrelation function (ACF) and mutual information (MI) function. Through analyzing the influence on TD signature in the region of injection current and injection strength for the slave SL, we find that, for both intensity chaos and phase chaos, the TD signature can be easily concealed under weak injection strength. When the injection strength is strong, we can not only successfully conceal TD signature, but also improve the bandwidth of chaotic laser output by choosing the optimal detuning frequency.

  10. Advanced in-duct sorbent injection for SO{sub 2} control. Topical report No. 4, Task 3, Optimized advanced process evaluation

    SciTech Connect

    Rosenhoover, W.A.; Stouffer, M.R.; Maskew, J.T.; Withum, J.A.; Wu, M.M.; Winschel, R.A.

    1994-12-01

    The objective of this research project is to develop second- generation duct injection technology as a cost-effective compliance option for the 1990 Clean Air Act Amendments. Specific performance targets are 90% SO{sup 2} removal and 60% sorbent utilization efficiency. Research focused on the Advanced Coolside process, which showed the potential for exceeding these targets. The objective of Subtask 3.1, Performance Testing, was to develop process performance and operability data for design and scale-up of the optimized Advance Coolside process. Results of long-term pilot plant testing with 24 hour/day operation provided a positive indication of process operability. The objective of Subtask 3.2, Waste Characterization, was to determine the chemical and physical properties of the waste materials for designing the waste handling and disposal systems for the process. Test results show that the combined spent sorbent and fly ash waste is suitable for landfilling. Further, the waste management study indicated a potential for by-product utilization for synthetic aggregate production; a more thorough investigation of this potential is required.

  11. Advanced development of double-injection, deep-impurity semiconductor switches

    NASA Technical Reports Server (NTRS)

    Hanes, M. H.

    1987-01-01

    Deep-impurity, double-injection devices, commonly refered to as (DI) squared devices, represent a class of semiconductor switches possessing a very high degree of tolerance to electron and neutron irradiation and to elevated temperature operation. These properties have caused them to be considered as attractive candidates for space power applications. The design, fabrication, and testing of several varieties of (DI) squared devices intended for power switching are described. All of these designs were based upon gold-doped silicon material. Test results, along with results of computer simulations of device operation, other calculations based upon the assumed mode of operation of (DI) squared devices, and empirical information regarding power semiconductor device operation and limitations, have led to the conculsion that these devices are not well suited to high-power applications. When operated in power circuitry configurations, they exhibit high-power losses in both the off-state and on-state modes. These losses are caused by phenomena inherent to the physics and material of the devices and cannot be much reduced by device design optimizations. The (DI) squared technology may, however, find application in low-power functions such as sensing, logic, and memory, when tolerance to radiation and temperature are desirable (especially is device performance is improved by incorporation of deep-level impurities other than gold.

  12. Recent Advances and Future Advances in Time-of-Flight PET

    PubMed Central

    Moses, William W.

    2007-01-01

    Simple theory predicts that the statistical noise variance in PET can be reduced by an order of magnitude by using time-of-flight (TOF) information. This reduction can be obtained by improving the coincidence timing resolution, and so would be achievable in clinical, whole body studies using with PET systems that differ little from existing cameras. The potential impact of this development is large, especially for oncology studies in large patients, where it is sorely needed. TOF PET was extensively studied in the 1980’s but died away in the 1990’s, as it was impossible to reliably achieve sufficient timing resolution without sacrificing other important PET performance aspects, such as spatial resolution and efficiency. Recent advances in technology (scintillators, photodetectors, and high speed electronics) have renewed interest in TOF PET, which is experiencing a rebirth. However, there is still much to be done, both in instrumentation development and evaluating the true benefits of TOF in modern clinical PET. This paper looks at what has been accomplished and what needs to be done before time-of-flight PET can reach its full potential. PMID:18836513

  13. An Advanced Real-Time Earthquake Information System in Japan

    NASA Astrophysics Data System (ADS)

    Takahashi, I.; Nakamura, H.; Suzuki, W.; Kunugi, T.; Aoi, S.; Fujiwara, H.

    2015-12-01

    J-RISQ (Japan Real-time Information System for earthquake) has been developing in NIED for appropriate first-actions to big earthquakes. When an earthquake occurs, seismic intensities (SI) are calculated first at each observation station and sent to the Data Management Center in different timing. The system begins the first estimation when the number of the stations observing the SI of 2.5 or larger exceeds the threshold amount. It estimates SI distribution, exposed population and earthquake damage on buildings by using basic data for estimation, such as subsurface amplification factors, population, and building information. It has been accumulated in J-SHIS (Japan Seismic Information Station) developed by NIED, a public portal for seismic hazard information across Japan. The series of the estimation is performed for each 250m square mesh and finally the estimated data is converted into information for each municipality. Since October 2013, we have opened estimated SI, exposed population etc. to the public through the website by making full use of maps and tables.In the previous system, we sometimes could not inspect the information of the surrounding areas out of the range suffered from strong motions, or the details of the focusing areas, and could not confirm whether the present information was the latest or not without accessing the website. J-RISQ has been advanced by introducing the following functions to settle those problems and promote utilization in local areas or in personal levels. In addition, the website in English has been released.・It has become possible to focus on the specific areas and inspect enlarged information.・The estimated information can be downloaded in the form of KML.・The estimated information can be updated automatically and be provided as the latest one.・The newest information can be inspected by using RSS readers or browsers corresponding to RSS.・Exclusive pages for smartphones have been prepared.The information estimated

  14. Safety Design Strategy for the Advanced Test Reactor Emergency Firewater Injection System Replacement Project

    SciTech Connect

    Noel Duckwitz

    2011-06-01

    In accordance with the requirements of U.S. Department of Energy (DOE) Order 413.3B, “Program and Project Management for the Acquisition of Capital Assets,” safety must be integrated into the design process for new or major modifications to DOE Hazard Category 1, 2, and 3 nuclear facilities. The intended purpose of this requirement involves the handling of hazardous materials, both radiological and chemical, in a way that provides adequate protection to the public, workers, and the environment. Requirements provided in DOE Order 413.3B and DOE Order 420.1B, “Facility Safety,” and the expectations of DOE-STD-1189-2008, “Integration of Safety into the Design Process,” provide for identification of hazards early in the project and use of an integrated team approach to design safety into the facility. This safety design strategy provides the basic safety-in-design principles and concepts that will be used for the Advanced Test Reactor Reliability Sustainment Project. While this project does not introduce new hazards to the ATR, it has the potential for significant impacts to safety-related systems, structures, and components that are credited in the ATR safety basis and are being replaced. Thus the project has been determined to meet the definition of a major modification and is being managed accordingly.

  15. An efficient time advancing strategy for energy-preserving simulations

    NASA Astrophysics Data System (ADS)

    Capuano, F.; Coppola, G.; de Luca, L.

    2015-08-01

    Energy-conserving numerical methods are widely employed within the broad area of convection-dominated systems. Semi-discrete conservation of energy is usually obtained by adopting the so-called skew-symmetric splitting of the non-linear convective term, defined as a suitable average of the divergence and advective forms. Although generally allowing global conservation of kinetic energy, it has the drawback of being roughly twice as expensive as standard divergence or advective forms alone. In this paper, a general theoretical framework has been developed to derive an efficient time-advancement strategy in the context of explicit Runge-Kutta schemes. The novel technique retains the conservation properties of skew-symmetric-based discretizations at a reduced computational cost. It is found that optimal energy conservation can be achieved by properly constructed Runge-Kutta methods in which only divergence and advective forms for the convective term are used. As a consequence, a considerable improvement in computational efficiency over existing practices is achieved. The overall procedure has proved to be able to produce new schemes with a specified order of accuracy on both solution and energy. The effectiveness of the method as well as the asymptotic behavior of the schemes is demonstrated by numerical simulation of Burgers' equation.

  16. Winning Strategies in Challenging Times for Advancing Small Colleges.

    ERIC Educational Resources Information Center

    Willmer, Wesley K., Ed.

    This volume contains nine papers on advancement issues and strategies for small colleges in the context of this decade's economic and social challenges. Chapter 1, "Setting the Stage" (Wesley K. Willmer), reports on a study of the advancement programs of smaller colleges in 1990-91, the third in a series of studies beginning in 1977-78. Chapter 2,…

  17. Premixed calcium silicate cement for endodontic applications: injectability, setting time and radiopacity.

    PubMed

    Persson, Cecilia; Engqvist, Håkan

    2011-01-01

    Calcium silicate-based materials (also called MTA) are increasingly being used in endodontic applications. However, the handling properties of MTA are not optimal when it comes to injectability and cohesion. Premixing the cements using glycerol avoids these issues. However, there is a lack of data on the effect of common cement variables on important properties of premixed cements for endodontic applications. In this study, the effects of liquid-to-powder ratio, amount of radiopacifier and amount of calcium sulfate (added to control the setting time) were screened using a statistical model. In the second part of the study, the liquid-to-powder ratio was optimized for cements containing three different amounts of radiopacifier. Finally, the effect of using glycerol rather than water was evaluated in terms of radiopacity. The setting time was found to increase with the amount of radiopacifier when the liquid-to-powder ratio was fixed. This was likely due to the higher density of the radiopacifier in comparison to the calcium silicate, which gave a higher liquid-to-powder ratio in terms of volume. Using glycerol rather than water to mix the cements led to a decrease in radiopacity of the cement. In conclusion, we were able to produce premixed calcium silicate cements with acceptable properties for use in endodontic applications.

  18. Achieving a stable time response in polymeric radiation sensors under charge injection by X-rays.

    PubMed

    Intaniwet, Akarin; Mills, Christopher A; Sellin, Paul J; Shkunov, Maxim; Keddie, Joseph L

    2010-06-01

    Existing inorganic materials for radiation sensors suffer from several drawbacks, including their inability to cover large curved areas, lack of tissue-equivalence, toxicity, and mechanical inflexibility. As an alternative to inorganics, poly(triarylamine) (PTAA) diodes have been evaluated for their suitability for detecting radiation via the direct creation of X-ray induced photocurrents. A single layer of PTAA is deposited on indium tin oxide (ITO) substrates, with top electrodes selected from Al, Au, Ni, and Pd. The choice of metal electrode has a pronounced effect on the performance of the device; there is a direct correlation between the diode rectification factor and the metal-PTAA barrier height. A diode with an Al contact shows the highest quality of rectifying junction, and it produces a high X-ray photocurrent (several nA) that is stable during continuous exposure to 50 kV Mo Kalpha X-radiation over long time scales, combined with a high signal-to-noise ratio with fast response times of less than 0.25 s. Diodes with a low band gap, 'Ohmic' contact, such as ITO/PTAA/Au, show a slow transient response. This result can be explained by the build-up of space charge at the metal-PTAA interface, caused by a high level of charge injection due to X-ray-induced carriers. These data provide new insights into the optimum selection of metals for Schottky contacts on organic materials, with wider applications in light sensors and photovoltaic devices.

  19. Daclizumab Injection

    MedlinePlus

    ... course of disease where symptoms flare up from time to time) of multiple sclerosis (MS; a disease in which ... injections. Before you use daclizumab yourself the first time, read the written instructions that come with it. ...

  20. Acyclovir Injection

    MedlinePlus

    ... chickenpox in the past) in people with weak immune systems. It is also used to treat first-time ... from time to time) in people with normal immune systems. Acyclovir injection is used to treat herpes simplex ...

  1. Effects of injection timing on nonlinear dynamics of the combustion process in the lean-burn premixed natural gas engine

    NASA Astrophysics Data System (ADS)

    Ding, Shun-Liang; Song, En-Zhe; Yang, Li-Ping; Yao, Chong; Ma, Xiu-Zhen

    2017-02-01

    The nonlinear dynamics of the combustion process in the lean-burn premixed natural gas engine are studied in this paper. Based on nonlinear dynamic theory, the complexity of the combustion process is analyzed under different injection timing conditions. The phase spaces are reconstructed for the experimentally obtained in-cylinder pressure real-time series and the return maps are plotted for the IMEP time series. The results of phase space reconstruction manifest that the attractors are limited to the finite range in the reconstructed phase space. The attractors have a folded and twist geometry structure. The attractors under medium injection timing conditions are looser and more complex. The return maps indicate the coexistence of the stochastic and deterministic components in the patterns combustion process. With the injection timing increasing, there are both a transition from stochastic to deterministic and a transition from deterministic to stochastic, forming the region of deterministic behavior. The largest Lyapunov exponents (LLE) for in-cylinder pressure time series are calculated and the coefficients of variations (COV) of IMEP are also analyzed. The results express that the LLE values are positive. There are a "steep increase" and a "steep decrease" for the LLE and COV values as the injection timing increasing.

  2. Timely injection of knowledge when interacting with stakeholders and policy makers.

    NASA Astrophysics Data System (ADS)

    Bouma, Johan

    2015-04-01

    Timely injection of knowledge when interacting with stakeholders and policy makers. J.Bouma Em. Prof. Soil Science, Wageningen University, the Netherlands During the last decade, the spectacular development of Information and Communication Technology (ICT) has strongly increased the accessible amount of data and information for stakeholders and policy makers and the science community is struggling to adjust to these developments. In the Netherlands not only industry has now a major impact on the research agenda but this is now to be extended to citizens at large. Rather than complain about an apparent "gap" between science and society and wrestle with the challenge to bridge it in a rather reactive manner, the science community would be well advised to initiate a proactive approach, showing that knowledge implies a deep understanding of issues and processes that does not necessarily follow from having data and information. The "gap" certainly applies to soil research in the context of sustainable development where many often well informed stakeholders are involved with widely different opinions, norms and values. Changes are suggested in the manner in which we frame our work: (i) longer involvement with projects from initiation to implementation in practice; (ii) active role of "knowledge brokers" who inject the right type of knowledge during the entire project run in a joint-learning mode, and (iii) not proposing new research from a science perspective but demonstrating a clear need because existing knowledge is inadequate. Yet more conceptual discussions about e.g. inter- and transdisciplinarity, worrysome soil degradation and lack of professional recognition are less meaningful than specific case studies demonstrating the crucial role of soil science when analysing land-based environmental problems. New narratives are needed instead of statistics, openness to learn from best practices and pilot projects as a necessary next step beyond awareness raising. Soil

  3. Edge localized mode characteristics during edge localized mode mitigation by supersonic molecular beam injection in Korea Superconducting Tokamak Advanced Research

    SciTech Connect

    Lee, H. Y.; Hong, J. H.; Jang, J. H.; Park, J. S.; Choe, Wonho; Hahn, S. H.; Bak, J. G.; Lee, J. H.; Ko, W. H.; Lee, K. D.; Lee, S. H.; Lee, H. H.; Juhn, J.-W.; Kim, H. S.; Yoon, S. W.; Han, H.; Ghim, Y.-C.

    2015-12-15

    It has been reported that supersonic molecular beam injection (SMBI) is an effective means of edge localized mode (ELM) mitigation. This paper newly reports the changes in the ELM, plasma profiles, and fluctuation characteristics during ELM mitigation by SMBI in Korea Superconducting Tokamak Advanced Research. During the mitigated ELM phase, the ELM frequency increased by a factor of 2–3 and the ELM size, which was estimated from the D{sub α} amplitude, the fractional changes in the plasma-stored energy and the line-averaged electron density, and divertor heat flux during an ELM burst, decreased by a factor of 0.34–0.43. Reductions in the electron and ion temperatures rather than in the electron density were observed during the mitigated ELM phase. In the natural ELM phase, frequency chirping of the plasma fluctuations was observed before the ELM bursts; however, the ELM bursts occurred without changes in the plasma fluctuation frequency in the mitigated ELM phase.

  4. Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis

    PubMed Central

    2011-01-01

    Introduction Intraarticular hyaluronan (HA) is used clinically for symptomatic relief in patients with knee osteoarthritis (OA); however, the mechanism of action is unclear. In this study, we examined the effects of a single injection of HA on joint tissue pathology, mechanical allodynia and gait changes (measured by stride times) in a murine model of OA. Methods OA was induced in the right knee joint (stifle) of 12-week-old male C57BL/6 mice by transforming growth factor β1 (TGFβ1) injection and treadmill running for 14 days. Gait parameters were quantified by using TreadScan, mechanical allodynia was evaluated with von Frey filaments, and joint pathology was evaluated by scoring of macroscopic images for both cartilage erosion and periarticular fibrosis. HA or saline control was injected 1 day after TGFβ1 injection but before the start of treadmill running. Results OA development in this model was accompanied by significant (P < 0.01) enhancement of the stance and propulsion times of affected legs. HA injection (but not saline injection) blocked all gait changes and also protected joints from femoral cartilage erosion as well as tibial and femoral tissue fibrosis. Both HA injection and saline injection attenuated acute allodynia, but the HA effect was more pronounced and prolonged than the saline injection. Conclusions We conclude that videographic gait analysis is an objective, sensitive and reproducible means of monitoring joint pathology in experimental murine OA, since stance time appears to correlate directly with OA severity. A single injection of HA prevents acute and prolonged gait changes and ameliorates the cartilage erosion and periarticular fibrosis normally seen in this model. We speculate that the capacity of HA to prevent cartilage erosion results from its normalization of joint biomechanics and its inhibitory effects on periarticular cells, which are involved in tissue hyperplasia and fibrosis. This effect of exogenous HA appears to mimic the

  5. Surface uplift and time-dependent seismic hazard due to fluid-injection in eastern Texas

    NASA Astrophysics Data System (ADS)

    Shirzaei, M.; Ellsworth, W. L.; Tiampo, K. F.; González, P. J.; Manga, M.

    2015-12-01

    US states such as Texas and Oklahoma that produce high-volumes of unconventional oil and gas, are facing a sharp increase in seismicity. Observations of the associated surface deformation and accompanying physical models that unequivocally link the seismicity and waste water injection are scarce. Here, we find that the waste water injection in eastern Texas causes uplift, detectable using radar interferometric data. Combining the uplift and injection data through a poroelastic model allows for the resolution of a complex crustal distribution of hydraulic conductivity and pore pressure. We find that the ~5 years pore pressure increase is capable of triggering the 17 May 2012, Mw 4.8 earthquake, the largest event recorded in east Texas. This study shows that surface deformation data are vital in order to constrain the spatiotemporal variations of the stress field in the vicinity of injection sites.

  6. Advancing Knowledge in Higher Education: Universities in Turbulent Times

    ERIC Educational Resources Information Center

    Fitzgerald, Tanya, Ed.

    2014-01-01

    Over the last three decades, higher education institutions have experienced massive changes. In particular, institutions of higher education have been positioned as a means to contribute to the knowledge economy and gain a level of competitive advantage in the global marketplace. "Advancing Knowledge in Higher Education: Universities in…

  7. Measurement of heating laser injection time to imploded core plasma by using x-ray framing camera

    SciTech Connect

    Koga, Mayuko; Fujiwara, Takashi; Sakaiya, Tatsuhiro; Lee, Myongdok; Shigemori, Keisuke; Shiraga, Hiroyuki; Azechi, Hiroshi

    2008-10-15

    A simultaneous measurement of imploded core plasma and injection time of heating laser is conducted by using an x-ray framing camera (XFC). The experiments are performed using Gekko XII laser system for implosion of the deuterated polystyrene (CD) plastic shell target and Peta Watt (PW) laser system for heating. The time of PW laser injection is observed as the bright zone in the XFC image. The measured x-ray intensity profiles fit the Gaussian profiles well. The calculations of microchannel plate by using dynode model explain these broadened temporal profiles qualitatively. The peak position of fitted x-ray intensity profile is almost in agreement with the time when the high energy x ray is observed by x-ray streak camera. Moreover, the peak position is delayed corresponding to the delayed setting of PW laser injection time. From these results, it is concluded that we can estimate the heating laser injection time with resolution of the order of 10 ps by using XFC.

  8. Intra-lesional injections of recombinant human epidermal growth factor promote granulation and healing in advanced diabetic foot ulcers: multicenter, randomised, placebo-controlled, double-blind study.

    PubMed

    Fernández-Montequín, José I; Valenzuela-Silva, Carmen M; Díaz, Odalys González; Savigne, William; Sancho-Soutelo, Natasha; Rivero-Fernández, Fidel; Sánchez-Penton, Pablo; Morejón-Vega, Lourdes; Artaza-Sanz, Heriberto; García-Herrera, Arístides; González-Benavides, Cecilio; Hernández-Cañete, Carlos M; Vázquez-Proenza, Alberto; Berlanga-Acosta, Jorge; López-Saura, Pedro A

    2009-12-01

    A multicenter, double-blind, placebo-controlled trial was carried out to evaluate the intra-lesional infiltration of recombinant epidermal growth factor (EGF) in Wagner's grade 3 or 4 diabetic foot ulcers (DFUs). Subjects (149) were randomised to receive EGF (75 or 25 microg) or placebo, three times per week for 8 weeks and standard good wound care. The main endpoint was granulation tissue covering > or = 50% of the ulcer at 2 weeks. It was achieved by 19/48 controls versus 44/53 in the 75 microg group [odds ratio (OR): 7.5; 95% confidence interval (CI): 2.9-18.9] and 34/48 in the 25 microg group (OR: 3.7; 1.6-8.7). Secondary outcome variables such as end-of-treatment complete granulation response (28/48 controls, 46/53 with 75 microg and 34/48 with 25 microg EGF), time-to-complete response (controls: 5 weeks; both EGF dose groups: 3 weeks), and wound closure after follow-up (25/48 controls, 40/53 with 75 microg and 25/48 with 25 microg EGF) were also treatment dependent. Multivariate analyses yielded that they were significantly enhanced by 75 microg EGF treatment and neuropathic versus ischemic ulcers. Most adverse events were mild and no drug-related severe adverse reactions were reported. It was concluded that recombinant human EGF (rhEGF) local injections offer a favourable risk-benefit balance in patients with advanced DFU.

  9. Clinical NECR in 18F-FDG PET scans: optimization of injected activity and variable acquisition time. Relationship with SNR

    NASA Astrophysics Data System (ADS)

    Carlier, T.; Ferrer, L.; Necib, H.; Bodet-Milin, C.; Rousseau, C.; Kraeber-Bodéré, F.

    2014-10-01

    The injected activity and the acquisition time per bed position for 18F-FDG PET scans are usually optimized by using metrics obtained from phantom experiments. However, optimal activity and time duration can significantly vary from a phantom set-up and from patient to patient. An approach using a patient-specific noise equivalent count rate (NECR) modelling has been previously proposed for optimizing clinical scanning protocols. We propose using the clinical NECR on a large population as a function of the body mass index (BMI) for deriving the optimal injected activity and acquisition duration per bed position. The relationship between the NEC and the signal-to-noise ratio (SNR) was assessed both in a phantom and in a clinical setting. 491 consecutive patients were retrospectively evaluated and divided into 4 BMI subgroups. Two criteria were used to optimize the injected activity and the time per bed position was adjusted using the NECR value while keeping the total acquisition time constant. Finally, the relationship between NEC and SNR was investigated using an anthropomorphic phantom and a population of 507 other patients. While the first dose regimen suggested a unique injected activity (665 MBq) regardless of the BMI, the second dose regimen proposed a variable activity and a total acquisition time according to the BMI. The NEC improvement was around 35% as compared with the local current injection rule. Variable time per bed position was derived according to BMI and anatomical region. NEC and number of true events were found to be highly correlated with SNR for the phantom set-up and partially confirmed in the patient study for the BMI subgroup under 28 kg m-2 suggesting that for the scanner, the nonlinear reconstruction algorithm used in this study and BMI < 28 kg m-2, NEC, or the number of true events linearly correlated with SNR2.

  10. Novel Advancements in Internet-Based Real Time Data Technologies

    NASA Technical Reports Server (NTRS)

    Myers, Gerry; Welch, Clara L. (Technical Monitor)

    2002-01-01

    AZ Technology has been working with MSFC Ground Systems Department to find ways to make it easier for remote experimenters (RPI's) to monitor their International Space Station (ISS) payloads in real-time from anywhere using standard/familiar devices. AZ Technology was awarded an SBIR Phase I grant to research the technologies behind and advancements of distributing live ISS data across the Internet. That research resulted in a product called "EZStream" which is in use on several ISS-related projects. Although the initial implementation is geared toward ISS, the architecture and lessons learned are applicable to other space-related programs. This paper presents the high-level architecture and components that make up EZStream. A combination of commercial-off-the-shelf (COTS) and custom components were used and their interaction will be discussed. The server is powered by Apache's Jakarta-Tomcat web server/servlet engine. User accounts are maintained in a My SQL database. Both Tomcat and MySQL are Open Source products. When used for ISS, EZStream pulls the live data directly from NASA's Telescience Resource Kit (TReK) API. TReK parses the ISS data stream into individual measurement parameters and performs on-the- fly engineering unit conversion and range checking before passing the data to EZStream for distribution. TReK is provided by NASA at no charge to ISS experimenters. By using a combination of well established Open Source, NASA-supplied. and AZ Technology-developed components, operations using EZStream are robust and economical. Security over the Internet is a major concern on most space programs. This paper describes how EZStream provides for secure connection to and transmission of space- related data over the public Internet. Display pages that show sensitive data can be placed under access control by EZStream. Users are required to login before being allowed to pull up those web pages. To enhance security, the EZStream client/server data transmissions can

  11. Numerical Investigation Into Effect of Fuel Injection Timing on CAI/HCCI Combustion in a Four-Stroke GDI Engine

    NASA Astrophysics Data System (ADS)

    Cao, Li; Zhao, Hua; Jiang, Xi; Kalian, Navin

    2006-02-01

    The Controlled Auto-Ignition (CAI) combustion, also known as Homogeneous Charge Compression Ignition (HCCI), was achieved by trapping residuals with early exhaust valve closure in conjunction with direct injection. Multi-cycle 3D engine simulations have been carried out for parametric study on four different injection timings in order to better understand the effects of injection timings on in-cylinder mixing and CAI combustion. The full engine cycle simulation including complete gas exchange and combustion processes was carried out over several cycles in order to obtain the stable cycle for analysis. The combustion models used in the present study are the Shell auto-ignition model and the characteristic-time combustion model, which were modified to take the high level of EGR into consideration. A liquid sheet breakup spray model was used for the droplet breakup processes. The analyses show that the injection timing plays an important role in affecting the in-cylinder air/fuel mixing and mixture temperature, which in turn affects the CAI combustion and engine performance.

  12. Failure to Influence the Rejection Time of Homologous Skin Grafts in the Rabbit by Prior Injection of Donor Blood*

    PubMed Central

    Piomelli, S.; Brooke, M. S.

    1961-01-01

    Intravenous injection of rabbits with homologous whole blood or erythrocytes did not influence the rejection time of subsequent grafts from the blood donors. In some animals warm agglutinins developed, and donor erythrocytes labelled with chromium had an immune disappearance slope. PMID:14486825

  13. Plasma models for real-time control of advanced tokamak scenarios

    NASA Astrophysics Data System (ADS)

    Moreau, D.; Mazon, D.; Walker, M. L.; Ferron, J. R.; Burrell, K. H.; Flanagan, S. M.; Gohil, P.; Groebner, R. J.; Hyatt, A. W.; La Haye, R. J.; Lohr, J.; Turco, F.; Schuster, E.; Ou, Y.; Xu, C.; Takase, Y.; Sakamoto, Y.; Ide, S.; Suzuki, T.; ITPA-IOS Group members; experts

    2011-06-01

    An integrated plasma profile control strategy, ARTAEMIS, is being developed for extrapolating present-day advanced tokamak (AT) scenarios to steady-state operation. The approach is based on semi-empirical modelling and was initially explored on JET (Moreau et al 2008 Nucl. Fusion 48 106001). This paper deals with the general applicability of this strategy for simultaneous magnetic and kinetic control on various tokamaks. The determination of the device-specific, control-oriented models that are needed to compute optimal controller matrices for a given operation scenario is discussed. The methodology is generic and can be applied to any device, with different sets of heating and current drive actuators, controlled variables and profiles. The system identification algorithms take advantage of the large ratio between the magnetic and thermal diffusion time scales and have been recently applied to both JT-60U and DIII-D data. On JT-60U, an existing series of high bootstrap current (~70%), 0.9 MA non-inductive AT discharges was used. The actuators consisted of four groups of neutral beam injectors aimed at perpendicular injection (on-axis and off-axis), and co-current tangential injection (also on-axis and off-axis). On DIII-D, dedicated system identification experiments were carried out in the loop voltage (Vext) control mode (as opposed to current control) to avoid feedback in the response data from the primary circuit. The reference plasma state was that of a 0.9 MA AT scenario which had been optimized to combine non-inductive current fractions near unity with 3.5 < βN < 3.9, bootstrap current fractions larger than 65% and H98(y,2) = 1.5. Actuators other than Vext were co-current, counter-current and balanced neutral beam injection, and electron cyclotron current drive. Power and loop voltage modulations resulted in dynamic variations of the plasma current between 0.7 and 1.2 MA. It is concluded that the response of essential plasma parameter profiles to specific

  14. Influence of the timing of HC injection on the preservation of petrophysical properties of carbonate reservoirs at great depth

    NASA Astrophysics Data System (ADS)

    Neveux, Lucille; Grgic, Dragan; Pironon, Jacques; Carpentier, Cédric; Girard, Jean-Pierre

    2013-04-01

    In the oil industry, the preservation of petrophysical properties at great depth may lead to the existence of a deeply buried reservoir (DBR), a favoured target in the field of petroleum exploration and exploitation. The accurate prediction of reservoir quality requires an understanding of the key controlling diagenetic processes. Pressure solution is one of the main processes happening during diagenesis and being responsible for the evolution of porosity and permeability in many reservoirs. However, others processes may potentially act upon carbonate rocks during diagenesis: the timing of oil arrival is one of these processes. The aim of this study is to investigate experimentally the influence of oil injection and timing of this injection on the pressure solution process and thus on carbonate petrophysical properties. The experiments were performed using a subsurface consolidated carbonate rock and a specifically designed experimental apparatus, enabling the simulation of in situ conditions (pressure/stresses and temperature) of deeply buried reservoirs. Three experiments were realised with different fluids and injection conditions, namely meteoric fluid as the interstitial fluid, early saturation in oil of the sample followed by the injection of a meteoric fluid, late injection of oil in a sample initially saturated with a meteoric fluid. The results obtained in this study showed that without oil in the interstitial fluid, the main diagenetic process is the pressure solution creep (PSC). This process reduces by three the initial porosity but don't have any significant influence on permeability. When the sample was initially saturated with oil before the injection of the meteoric fluid, the process of PSC was inhibited. In this case, the porosity showed a slight decrease and the permeability showed a strong decrease from 23 mD to 1 mD. When an initially saturated (with a meteoric fluid) sample undergone a late injection of oil, the porosity was not preserved and

  15. Advancing health equity to improve health: the time is now.

    PubMed

    Jackson, B; Huston, P

    2016-02-01

    Health inequities, or avoidable inequalities in health between groups of people, are increasingly recognized and tackled to improve public health. Canada's interest in health inequities goes back over 40 years, with the landmark 1974 Lalonde report, and continues with the 2011 Rio Political Declaration on Social Determinants of Health, which affirmed a global political commitment to implementing a social determinants of health approach to reducing health inequities. Research in this area includes documenting and tracking health inequalities, exploring their multidimensional causes, and developing and evaluating ways to address them. Inequalities can be observed in who is vulnerable to infectious and chronic diseases, the impact of health promotion and disease prevention efforts, how disease progresses, and the outcomes of treatment. Many programs, policies and projects with potential impacts on health equity and determinants of health have been implemented across Canada. Recent theoretical and methodological advances in the areas of implementation science and population health intervention research have strengthened our capacity to develop effective interventions. With the launch of a new health equity series this month, the journals Canada Communicable Disease Report and Health Promotion and Chronic Disease Prevention in Canada will continue to reflect and foster analysis of social determinants of health and focus on intervention studies that advance health equity.

  16. Design and Implementation of a CO2 Flood Utilizing Advanced Reservoir Characterization and Horizontal Injection Wells In a Shallow Shelf Carbonate Approaching Waterflood Depletion, Class II

    SciTech Connect

    Wier, Don R. Chimanhusky, John S.; Czirr, Kirk L.; Hallenbeck, Larry; Gerard, Matthew G.; Dollens, Kim B.; Owen, Rex; Gaddis, Maurice; Moshell, M.K.

    2002-11-18

    The purpose of this project was to economically design an optimum carbon dioxide (CO2) flood for a mature waterflood nearing its economic abandonment. The original project utilized advanced reservoir characterization and CO2 horizontal injection wells as the primary methods to redevelop the South Cowden Unit (SCU). The development plans; project implementation and reservoir management techniques were to be transferred to the public domain to assist in preventing premature abandonment of similar fields.

  17. [Evaluation of short-time premedication with d-chlorpheniramine maleate injection for paclitaxel-induced hypersensitivity reaction].

    PubMed

    Harada, Tomohiko; Doi, Masakazu; Yamada, Yasuhiko; Akase, Tomohide

    2008-08-01

    Paclitaxel(referred to hereinafter as PTX )is used in ovarian cancer, non-small cell lung cancer, breast cancer, gastric cancer, and endometrial cancer with positive treatment result reports. However, severe allergic reactions such as decreases in blood pressure and impaired breathing occur with relatively high frequency. For the prevention of such allergic reactions, administration of a premedication composed of the three components, dexamethasone sodium phosphate injection, diphenhydramine hydrochloride tablet, and ranitidine hydrochloride injection solution(or injectable famodine), is advised in the appended documentation. Administration is difficult because, among these three components, only diphenhydramine hydrochloride is administered orally and thus must be provided through the internal medicine department. Particularly when this combined dosage is administered as outpatient chemotherapy, the doctor must prescribe diphenhydramine hydrochloride tablets, and the patient must not forget to bring them on the day in which chemotherapy is administered. Also, checks by the medical staff such as pharmacists and nurses are required, complicating the administration of this therapy further. Taking this situation into consideration, our hospital uses a short-time premedication method wherein d-Chlorpheniramine Maleate injections are substituted for diphenhydramine hydrochloride tablets, and the time required for premedication is reduced to 15 minutes. This study investigated the allergic reaction ratio to consider the safety and usefulness of the short-time premedication method used at our hospital. The chemotherapy regimens conducted for the subject patients were 9 cases of PTX+CBDCA, 6 cases of biweekly- PTX, and 5 cases of weekly-PTX. A total of 67 PTX injections were given, 15 of them being first-time administrations. The ratio of allergic/hypersensitivity reactions was 10.0%(2 cases in 20). The short-time premedication method using d-Chlorpheniramine Maleate

  18. Recent advances to obtain real - Time displacements for engineering applications

    USGS Publications Warehouse

    Celebi, M.

    2005-01-01

    This paper presents recent developments and approaches (using GPS technology and real-time double-integration) to obtain displacements and, in turn, drift ratios, in real-time or near real-time to meet the needs of the engineering and user community in seismic monitoring and assessing the functionality and damage condition of structures. Drift ratios computed in near real-time allow technical assessment of the damage condition of a building. Relevant parameters, such as the type of connections and story structural characteristics (including geometry) are used in computing drifts corresponding to several pre-selected threshold stages of damage. Thus, drift ratios determined from real-time monitoring can be compared to pre-computed threshold drift ratios. The approaches described herein can be used for performance evaluation of structures and can be considered as building health-monitoring applications.

  19. Influence of Dupree diffusivity on the occurrence scattering time advance in turbulent plasmas

    SciTech Connect

    Lee, Myoung-Jae; Jung, Young-Dae

    2015-12-15

    The influence of Dupree diffusivity on the occurrence scattering time advance for the electron-ion collision is investigated in turbulent plasmas. The second-order eikonal method and the effective Dupree potential term associated with the plasma turbulence are employed to obtain the occurrence scattering time as a function of the diffusion coefficient, impact parameter, collision energy, thermal energy, and Debye length. The result shows that the occurrence scattering time advance decreases with an increase of the Dupree diffusivity. Hence, we have found that the influence of plasma turbulence diminishes the occurrence time advance in forward electron-ion collisions in thermal turbulent plasmas. The occurrence time advance shows that the propensity of the occurrence time advance increases with increasing scattering angle. It is also found that the effect of turbulence due to the Dupree diffusivity on the occurrence scattering time advance decreases with an increase of the thermal energy. In addition, the variation of the plasma turbulence on the occurrence scattering time advance due to the plasma parameters is also discussed.

  20. Advancing critical care: time to kiss the right frog

    PubMed Central

    2013-01-01

    The greatest advances in critical care over the past two decades have been achieved through doing less to the patient. We have learnt through salutary experience that our burgeoning Master-of-the-Universe capabilities and the oh-so-obvious stratagems instilled in us from youth were often ineffective or even deleterious. This re-education process, however, is far from complete. We are now rightly agonizing over the need for better characterization of pathophysiology, earlier identification of disease processes and a more directed approach to therapeutic intervention. We need to delineate the point at which intrinsic and protective adaptation ends and true harmful pathology begins, and how our iatrogenic meddling either helps or hinders. We need to improve trial design in the heterogeneous populations we treat, and to move away from syndromic fixations that, while offering convenience, have generally proved counterproductive. Importantly, we need to discover a far more holistic approach to patient care, evolving from the prevailing overmedicalized, number-crunching perspective towards a true multidisciplinary effort that embraces psychological as well as physiological well-being, with appropriate pharmacological minimization or supplementation. Complacency, with an unfair apportion of blame on the patient for not getting better, is the biggest threat to continued improvement. PMID:23514321

  1. Alemtuzumab Injection

    MedlinePlus

    ... injection, the medication is usually given three times weekly on alternate days (usually Monday, Wednesday, and Friday) ... that you eat foods that are rich in iron such as meats, leafy green vegetables, and fortified ...

  2. Real-time PCR: Advanced technologies and applications

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This book brings together contributions from 20 experts in the field of PCR, providing a broad perspective of the applications of quantitative real-time PCR (qPCR). The editors state in the preface that the aim is to provide detailed insight into underlying principles and methods of qPCR to provide ...

  3. Time Pressure and Phonological Advance Planning in Spoken Production

    ERIC Educational Resources Information Center

    Damian, Markus F.; Dumay, Nicolas

    2007-01-01

    Current accounts of spoken production debate the extent to which speakers plan ahead. Here, we investigated whether the scope of phonological planning is influenced by changes in time pressure constraints. The first experiment used a picture-word interference task and showed that picture naming latencies were shorter when word distractors shared…

  4. Advances in time-dependent methods for multiphoton processes

    SciTech Connect

    Kulander, K.C.; Schafer, K.J.; Krause, J.L.

    1990-09-01

    This paper discusses recent theoretical results on above threshold ionization harmonic generation and high-frequency, high intensity suppression of ionization. These studies of multiphoton processes in atoms and molecules for short, intense pulsed optical lasers have been carried out using techniques which involve the explicit solution of the time-dependent Schroedinger equation. 43 refs., 5 figs.

  5. Precision Pulsar Timing and Gravity Waves: Recent Advances in Instrumentation

    NASA Astrophysics Data System (ADS)

    Demorest, P.; Ramachandran, R.; Backer, D.; Ferdman, R.; Stairs, I.; Nice, D.

    2004-12-01

    High-precision pulsar timing is a unique and useful tool for many different scientific applications, including studies of the interstellar medium, relativistic binary systems, and long period gravitational wave studies. Our group has designed and installed a new generation of pulsar instrumentation at several radio observatories over the past year: The Arecibo Signal Processor (ASP), the Green Bank Astronomical Signal Processor (GASP), and the Berkeley-Orleans-Nancay processor (BON). These machines perform real time coherent dedispersion of the pulsar signal on up to 64 MHz of bandwidth, and quasi-real time up to 128 MHz. They use high dynamic range voltage sampling (8 bits), which significantly reduces digitization artifacts. The processing is done in an array of personal computers, which makes the machines extremely flexible for future development. We present preliminary results from several different studies using this new instrumentation. At Green Bank, we have initiated a program of long-term precision timing of 15 pulsars using the 100m Green Bank Telescope. The data from this project will be used to study binary systems, and contribute to the ongoing multi-observatory effort to create a Pulsar Timing Array - a group of many pulsars distributed about the sky which can be used to detect gravitational radiation with a period of 1-10 years. We also have continuous use of a 85ft telescope at Green Bank which we have used to study dispersion measure fluctuations of PSR B1937+21 on timescales of 1 day to several years. These fluctuations are a potential systematic effect for the gravity wave study, and also help us learn more about the nature of interstellar weather.

  6. Effect of Water-Alcohol Injection and Maximum Economy Spark Advance on Knock-Limited Performance and Fuel Economy of a Large Air-Cooled Cylinder

    NASA Technical Reports Server (NTRS)

    Heinicke, Orville H.; Vandeman, Jack E.

    1945-01-01

    An investigation was conducted to determine the effect of a coolant solution of 25 percent ethyl alcohol, 25 percent methyl alcohol, and 50 percent water by volume and maximum-economy spark advance on knock-limited performance and fuel economy of a large air-cooled cylinder. The knock-limited performance of the cylinder at engine speeds of 2100 and 2500 rpm was determined for coolant-fuel ratios of 0.0, 0.2, and 0.4. The effect of water-alcohol injection on fuel economy was determined in constant charge-air flow tests. The tests were conducted at a spark advance of 20 deg B.T.C. and maximum-economy spark advance.

  7. Effect of lithosperm on thyroidal /sup 32/P uptake at various times of injection

    SciTech Connect

    Breneman, W.R.; Zeller, F.J.

    1983-06-01

    These experiments were performed to increase our understanding of possible side effects in the use of extracts of the plant Lithospermum ruderale (LSPM) as a contraceptive. Cold-water extracts of LSPM were used to note possible effects on injected TSH and on endogenous TSH which was increased by the use of propylthiouracil. It was demonstrated that LSPM had a biphasic effect on both endogenous and exogenous TSH activity as measured by chick thyroid /sup 32/P uptake. When given 18h before autopsy, LSPM decreased TSH activity in both, whereas when LSPM was administered 42h or 44h before autopsy, TSH activity was significantly increased.

  8. Injection overview

    SciTech Connect

    Prestwich, S.

    1983-12-01

    The test program was initiated at the Raft River Geothermal Field in southern Idaho in September 1982. A series of eight short-term injection and backflow tests, followed by a long-term injection test, were conducted on one well in the field. Tracers were added during injection and monitored during backflow as well. The principal objective was to determine if tracers could be effectively used as a means to assess reservoir characteristics in a one-well test. The test program resulted in a unique data set which shows promise as a means to improve understanding of the reservoir characteristics. In December 1982, an RFP was issued to obtain an industrial partner to obtain follow-on data on the injection/backflow technique in a second field, and to study any alternate advanced concepts for injection testing which the industrial community might recommend. The East Mesa Geothermal Field was selected for the second test series. Two wells were utilized for testing, and a series of ten tests were conducted in July and August 1983, aimed principally at further evaluation of the injection/backflow technique.

  9. Fuel injection pump having a compact spill-port timing control unit

    SciTech Connect

    Matsumura, T.; Miyaki, M.; Masuda, A.

    1986-03-04

    This patent describes a fuel injection pump. This pump consists of a compression chamber adapted to be coupled to a source of fuel; fuel injection nozzles; a rotary plunger rotatably driven by an internal combustion engine, the plunger including means for defining a common passageway connected at one end to the compression chamber, the plunger further including means for defining angularly spaced apart spill ports branching off the common passageway to an outside surface thereof and a fuel delivery port branching off the common passageway, the fuel delivery port being selectively movable into and out of alignment with each one of the nozzles by rotation of the plunger; a magnetized rotary ring including means for defining a spill groove extending along the inner wall thereof, the ring being mounted on the plunger and rotatable, with respect to the plunger, between at least a first angular position, the ring consists of a cylindrical structure having differently magnetized equally divided arcuate sections, the groove being formed on the inner wall of the cylindrical structure and substantially axially extending from one end of the structure; spring means for biasing the ring toward one of the first and second angular positions; a stationary core surrounding the ring; and a coil wound on the core for generating a rotative thrust on the ring for selectively moving the ring between the first and second angular positions in response to a control signal.

  10. Advances in time-dependent current-density functional theory

    NASA Astrophysics Data System (ADS)

    Berger, Arjan

    In this work we solve the problem of the gauge dependence of molecular magnetic properties (magnetizabilities, circular dichroism) using time-dependent current-density functional theory [1]. We also present a new functional that accurately describes the optical absorption spectra of insulators, semiconductors and metals [2] N. Raimbault, P.L. de Boeij, P. Romaniello, and J.A. Berger Phys. Rev. Lett. 114, 066404 (2015) J.A. Berger, Phys. Rev. Lett. 115, 137402 (2015) This study has been partially supported through the Grant NEXT No. ANR-10-LABX-0037 in the framework of the Programme des Investissements d'Avenir.

  11. Recent advances in phase shifted time averaging and stroboscopic interferometry

    NASA Astrophysics Data System (ADS)

    Styk, Adam; Józwik, Michał

    2016-08-01

    Classical Time Averaging and Stroboscopic Interferometry are widely used for MEMS/MOEMS dynamic behavior investigations. Unfortunately both methods require an extensive measurement and data processing strategies in order to evaluate the information on maximum amplitude at a given load of vibrating object. In this paper the modified strategies of data processing in both techniques are introduced. These modifications allow for fast and reliable calculation of searched value, without additional complication of measurement systems. Through the paper the both approaches are discussed and experimentally verified.

  12. Investigation using an advanced extremity gamma instrumentation system of options for shielding the hand during the preparation and injection of radiopharmaceuticals.

    PubMed

    Whitby, M; Martin, C J

    2003-03-01

    Staff preparing and injecting radiopharmaceuticals in hospitals may receive significant radiation doses to their hands. These doses may be high enough to warrant that they be classified as radiation workers. The influence of local shielding on finger doses has been investigated. Staff preparing radioactive liquids in a radionuclide dispensary and drawing up and injecting radiopharmaceuticals in a nuclear medicine department have been studied. Measurements have been recorded with an electronic extremity dose monitor, an advanced extremity gamma instrumentation system (AEGIS), worn near to the finger tip. The electronic dosimeter allows the pattern of doses received during different procedures to be determined. Doses received for individual manipulations during many routine sessions have been recorded for different staff members. Dose distributions around shielded vials and syringes have also been measured using AEGIS. In the radionuclide dispensary the vials from which radioactive liquids are dispensed are held in tungsten shields, whereas in nuclear medicine simple lead pots are used. Syringe shields are employed for some parts of dispensing and patient injections. Data on dose distributions have been used in interpretation of results from monitoring. Use of syringe shields during dispensing reduced the finger dose by 75-85%. The peaks in dose rate were 60% lower, and periods of exposure to high dose rates were reduced in length by a third because of the restriction in the region of high dose rate. The extremity doses to staff dispensing and injecting radiopharmaceuticals in nuclear medicine were of similar magnitude. Doses received during dispensing varied from 10 to 555 microGy depending upon whether the vial containing the radiopharmaceutical was directly handled or not. Dose received from individual injections varied from 1 to 150 microGy depending on the degree of difficulty experienced during the injection.

  13. Advanced tools for astronomical time series and image analysis

    NASA Astrophysics Data System (ADS)

    Scargle, Jeffrey D.

    The algorithms described here, which I have developed for applications in X-ray and γ-ray astronomy, will hopefully be of use in other ways, perhaps aiding in the exploration of modern astronomy's data cornucopia. The goal is to describe principled approaches to some ubiquitous problems, such as detection and characterization of periodic and aperiodic signals, estimation of time delays between multiple time series, and source detection in noisy images with noisy backgrounds. The latter problem is related to detection of clusters in data spaces of various dimensions. A goal of this work is to achieve a unifying view of several related topics: signal detection and characterization, cluster identification, classification, density estimation, and multivariate regression. In addition to being useful for analysis of data from space-based and ground-based missions, these algorithms may be a basis for a future automatic science discovery facility, and in turn provide analysis tools for the Virtual Observatory. This chapter has ties to those by Larry Bretthorst, Tom Loredo, Alanna Connors, Fionn Murtagh, Jim Berger, David van Dyk, Vicent Martinez & Enn Saar.

  14. Interglacial climate dynamics and advanced time series analysis

    NASA Astrophysics Data System (ADS)

    Mudelsee, Manfred; Bermejo, Miguel; Köhler, Peter; Lohmann, Gerrit

    2013-04-01

    Studying the climate dynamics of past interglacials (IGs) helps to better assess the anthropogenically influenced dynamics of the current IG, the Holocene. We select the IG portions from the EPICA Dome C ice core archive, which covers the past 800 ka, to apply methods of statistical time series analysis (Mudelsee 2010). The analysed variables are deuterium/H (indicating temperature) (Jouzel et al. 2007), greenhouse gases (Siegenthaler et al. 2005, Loulergue et al. 2008, L¨ü thi et al. 2008) and a model-co-derived climate radiative forcing (Köhler et al. 2010). We select additionally high-resolution sea-surface-temperature records from the marine sedimentary archive. The first statistical method, persistence time estimation (Mudelsee 2002) lets us infer the 'climate memory' property of IGs. Second, linear regression informs about long-term climate trends during IGs. Third, ramp function regression (Mudelsee 2000) is adapted to look on abrupt climate changes during IGs. We compare the Holocene with previous IGs in terms of these mathematical approaches, interprete results in a climate context, assess uncertainties and the requirements to data from old IGs for yielding results of 'acceptable' accuracy. This work receives financial support from the Deutsche Forschungsgemeinschaft (Project ClimSens within the DFG Research Priority Program INTERDYNAMIK) and the European Commission (Marie Curie Initial Training Network LINC, No. 289447, within the 7th Framework Programme). References Jouzel J, Masson-Delmotte V, Cattani O, Dreyfus G, Falourd S, Hoffmann G, Minster B, Nouet J, Barnola JM, Chappellaz J, Fischer H, Gallet JC, Johnsen S, Leuenberger M, Loulergue L, Luethi D, Oerter H, Parrenin F, Raisbeck G, Raynaud D, Schilt A, Schwander J, Selmo E, Souchez R, Spahni R, Stauffer B, Steffensen JP, Stenni B, Stocker TF, Tison JL, Werner M, Wolff EW (2007) Orbital and millennial Antarctic climate variability over the past 800,000 years. Science 317:793. Köhler P, Bintanja R

  15. Time since migration and HIV risk behaviors among Puerto Ricans who inject drugs in New York City

    PubMed Central

    Gelpí-Acosta, C; Pouget, ER; Reilly, KH; Hagan, H; Neaigus, A; Wendel, T; Marshall, D

    2016-01-01

    BACKGROUND Among people who inject drugs (PWID) in the U.S., those who initiated drug injection in Puerto Rico (immigrant Puerto Rican PWID) engage in more injection and sexual risk behaviors, and have higher HIV incidence than non-Hispanic whites. OBJECTIVE Understand the persistence of HIV risk behaviors. METHODS In a cross-sectional study conducted in New York City (NYC) in 2012 (National HIV Behavioral Surveillance), PWID aged ≥ 18 years were recruited using Respondent-Driven Sampling, interviewed, and tested for HIV. Participants were categorized into 5 different groups: (1) US-born non-Hispanic PWID, (2) US-born Puerto Rican PWID, (3) recent immigrant Puerto Rican PWID (≤ 3 years in NYC), (4) medium-term immigrant Puerto Rican PWID (> 3 and ≤ 10 years in NYC), and (5) long-term immigrant Puerto Rican PWID (> 10 years in NYC). We examined the relationship between time since migrating on sexual and injection risk behaviors among immigrant Puerto Rican PWID, compared with U.S.-born Puerto Rican PWID and US-born non-Hispanic PWID. Adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) were estimated using logistic regression. RESULTS A total of 481 PWID were recruited. In adjusted analyses using US-born non-Hispanic PWID as the comparison group, syringe sharing was significantly more likely among medium-term immigrants; and unprotected sex with casual partners was more likely among recent and long-term immigrants. CONCLUSIONS The risk-acculturation process for immigrant Puerto Rican PWID may be non-linear and may not necessarily lead to risk reduction over time. Research is needed to better understand this process. PMID:27100322

  16. [Advances of the Chinese Journal of Ophthalmology with the times].

    PubMed

    Zhao, Hong-mei

    2005-08-01

    Since the first publication of the Chinese Journal of Ophthalmology on October 1st, 1950, following the establishment of the People's Republic of China, more than fifty years have already elapsed. The editors and publishers of the elder generation of this magazine have witnessed the hardships in starting publication, the disappointments of the discontinuation of publication during certain periods, as well as the great delight of restarting publication. Having entered the 21st century, editors and publishers of the new generation have made dramatic achievements by keeping up with the times and continuously seeking innovations. However all of these achievements have only turned out to be the past. There are even more challenges for moving ahead in the future. The Chinese Journal of Ophthalmology has noted its achievements on the one hand; while on the other hand, has analyzed the main existing problems of this magazine. Some feasible approaches to improve the magazine have been proposed and the direction in the following few years was ascertained. We will collaborate with Chinese ophthalmologists to work towards the continuous development of this magazine.

  17. Advances on Sensitive Electron-injection based Cameras for Low-Flux, Short-Wave-Infrared Applications

    NASA Astrophysics Data System (ADS)

    Fathipour, Vala; Bonakdar, Alireza; Mohseni, Hooman

    2016-08-01

    Short-wave infrared (SWIR) photon detection has become an essential technology in the modern world. Sensitive SWIR detector arrays with high pixel density, low noise levels and high signal-to-noise-ratios are highly desirable for a variety of applications including biophotonics, light detection and ranging, optical tomography, and astronomical imaging. As such many efforts in infrared detector research are directed towards improving the performance of the photon detectors operating in this wavelength range. We review the history, principle of operation, present status and possible future developments of a sensitive SWIR detector technology, which has demonstrated to be one of the most promising paths to high pixel density focal plane arrays for low flux applications. The so-called electron-injection (EI) detector was demonstrated for the first time (in 2007). It offers an overall system-level sensitivity enhancement compared to the p-i-n diode due to a stable internal avalanche-free gain. The amplification method is inherently low noise, and devices exhibit an excess noise of unity. The detector operates in linear-mode and requires only bias voltage of a few volts. The stable detector characteristics, makes formation of high yield large-format, and high pixel density focal plane arrays less challenging compared to other detector technologies such as avalanche photodetectors. Detector is based on the mature InP material system (InP/InAlAs/GaAsSb/InGaAs), and has a cutoff wavelength of 1700 nm. It takes advantage of a unique three-dimensional geometry and combines the efficiency of a large absorbing volume with the sensitivity of a low-dimensional switch (injector) to sense and amplify signals. Current devices provide high-speed response ~ 5 ns rise time, and low jitter ~ 12 ps at room temperature. The internal dark current density is ~ 1 μA/cm2 at room temperature decreasing to 0.1 nA/cm2 at 160 K. EI detectors have been designed, fabricated, and tested during two

  18. Living Fully in the Shadow of Mortal Time: Psychosocial Assets in Advanced Cancer

    PubMed Central

    Wise, Meg; Marchand, Lucille

    2013-01-01

    Objective To characterize the strategies and psychosocial conditions that influence how resilient people live in the face of advanced cancer. Methods Grounded theory interviews and surveys of ten resilient people with advanced cancer were collected and analyzed. Findings Personal assets including positive relationships, purpose in life, faith, and a sense of mastery contributed to living fully in “mortal time.” Strategies included embracing paradox, reframing time, deepening connections, and aligning actions with priorities. Open-ended interviews yielded rich illness and life stories; many participants requested a copy of the transcript. Conclusions Resilient people use a range of strategies to thrive in the face of advanced cancer. PMID:23923470

  19. Editorial Commentary: The Time Has Come to Try Intra-articular Platelet-Rich Plasma Injections for Your Patients With Symptomatic Knee Osteoarthritis.

    PubMed

    Hunt, Timothy J

    2017-03-01

    Platelet-rich plasma injections, in a systematic review and meta-analysis of 10 Level I randomized control trials, were found to provide more pain relief and better functional outcomes than hyaluronic acid in patients with knee osteoarthritis at 12 months after injection. The time has come for those of us who have not yet tried platelet-rich plasma injections in our patients with symptomatic knee osteoarthritis to do so.

  20. 48 CFR 1552.215-74 - Advanced understanding-uncompensated time.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... hours delivered during the contract. In the event there is a shortage of uncompensated time hours...-uncompensated time. 1552.215-74 Section 1552.215-74 Federal Acquisition Regulations System ENVIRONMENTAL... Clauses 1552.215-74 Advanced understanding—uncompensated time. As prescribed in 1515.408(b), insert...

  1. Real-Time Ultrasound/MRI Fusion for Suprasacral Parallel Shift Approach to Lumbosacral Plexus Blockade and Analysis of Injectate Spread: An Exploratory Randomized Controlled Trial

    PubMed Central

    Pedersen, Erik Morre; Al-Karradi, Sinan Naseer Hussain; Bendtsen, Mathias Alrø Fichtner; Bjørn, Siska; Dam, Mette; Daugaard, Morten; Hansen, Martin Sejr; Linnet, Katrine Danker; Søballe, Kjeld

    2017-01-01

    Fused real-time ultrasound and magnetic resonance imaging (MRI) may be used to improve the accuracy of advanced image guided procedures. However, its use in regional anesthesia is practically nonexistent. In this randomized controlled crossover trial, we aim to explore effectiveness, procedure-related outcomes, injectate spread analyzed by MRI, and safety of ultrasound/MRI fusion versus ultrasound guided Suprasacral Parallel Shift (SSPS) technique for lumbosacral plexus blockade. Twenty-six healthy subjects aged 21–36 years received two SSPS blocks (20 mL 2% lidocaine-epinephrine [1 : 200,000] added 1 mL diluted contrast) guided by ultrasound/MRI fusion versus ultrasound. Number (proportion) of subjects with motor blockade of the femoral and obturator nerves and the lumbosacral trunk was equal (ultrasound/MRI, 23/26 [88%]; ultrasound, 23/26 [88%]; p = 1.00). Median (interquartile range) preparation and procedure times (s) were longer for the ultrasound/MRI fusion guided technique (686 [552–1023] versus 196 [167–228], p < 0.001 and 333 [254–439] versus 216 [176–294], p = 0.001). Both techniques produced perineural spread and corresponding sensory analgesia from L2 to S1. Epidural spread and lidocaine pharmacokinetics were similar. Different compartmentalized patterns of injectate spread were observed. Ultrasound/MRI fusion guided SSPS was equally effective and safe but required prolonged time, compared to ultrasound guided SSPS. This trial is registered with EudraCT (2013-004013-41) and ClinicalTrials.gov (NCT02593370).

  2. Unidirectional transparent signal injection in finite-difference time-domain electromagnetic codes -application to reflectometry simulations

    SciTech Connect

    Silva, F. da; Hacquin, S.

    2005-03-01

    We present a novel numerical signal injection technique allowing unidirectional injection of a wave in a wave-guiding structure, applicable to 2D finite-difference time-domain electromagnetic codes, both Maxwell and wave-equation. It is particularly suited to continuous wave radar-like simulations. The scheme gives an unidirectional injection of a signal while being transparent to waves propagating in the opposite direction (directional coupling). The reflected or backscattered waves (returned) are separated from the probing waves allowing direct access to the information on amplitude and phase of the returned wave. It also facilitates the signal processing used to extract the phase derivative (or group delay) when simulating radar systems. Although general, the technique is particularly suited to swept frequency sources (frequency modulated) in the context of reflectometry, a fusion plasma diagnostic. The UTS applications presented here are restricted to fusion plasma reflectometry simulations for different physical situations. This method can, nevertheless, also be used in other dispersive media such as dielectrics, being useful, for example, in the simulation of plasma filled waveguides or directional couplers.

  3. An improved method for the determination of 5-hydroxymethylfurfural in Shenfu injection by direct analysis in real time-quadrupole time-of-flight mass spectrometry.

    PubMed

    Gao, Wen; Qi, Lian-Wen; Liu, Charles C; Wang, Rui; Li, Ping; Yang, Hua

    2016-07-01

    The emergence of direct analysis in real time (DART) ion source provides the great possibility for rapid analysis of hazardous substance in drugs. DART mass spectrometry (DART-MS) enabled the conducting of a fast and non-contact analysis of various samples, including solid or liquid ones, without complex sample preparation or chromatographic separation. In this study, a modified DART-quadrupole time-of-flight mass spectrometry (DART-QTOF-MS) method was developed for identification and determination of 5-hydroxymethylfurfural (5-HMF) in Shenfu (SF) injection. The quantitative transfer of sample solution was introduced to the glass tips of DIP-it sampler at a fixed volume, which significantly increases the repeatability and accuracy of analytical results. The protonated ion of dibutyl phthalate in the atmosphere was used as the reference mass for TOF-MS recalibration during the data acquisition for constant high accuracy mass measurements. Finally, the developed DART-MS method was used to determine 5-HMF in seven batches of SF injection, and the contents of 5-HMF were not higher than 100 µg/mL. The results obtained were further confirmed by an ultra-high performance liquid chromatography combined with triple quadrupole mass spectrometer (UHPLC-QQQ-MS). The overall results demonstrated that the DART-QTOF-MS method could be applied as an alternative technique for rapid monitoring 5-HMF in herbal medicine injection. Copyright © 2015 John Wiley & Sons, Ltd.

  4. Retrieval and intercomparison of volcanic SO2 injection height and eruption time from satellite maps and ground-based observations

    NASA Astrophysics Data System (ADS)

    Pardini, Federica; Burton, Mike; de'Michieli Vitturi, Mattia; Corradini, Stefano; Salerno, Giuseppe; Merucci, Luca; Di Grazia, Giuseppe

    2017-02-01

    Syneruptive gas flux time series can, in principle, be retrieved from satellite maps of SO2 collected during and immediately after volcanic eruptions, and used to gain insights into the volcanic processes which drive the volcanic activity. Determination of the age and height of volcanic plumes are key prerequisites for such calculations. However, these parameters are challenging to constrain using satellite-based techniques. Here, we use imagery from OMI and GOME-2 satellite sensors and a novel numerical procedure based on back-trajectory analysis to calculate plume height as a function of position at the satellite measurement time together with plume injection height and time at a volcanic vent location. We applied this new procedure to three Etna eruptions (12 August 2011, 18 March 2012 and 12 April 2013) and compared our results with independent satellite and ground-based estimations. We also compare our injection height time-series with measurements of volcanic tremor, which reflects the eruption intensity, showing a good match between these two datasets. Our results are a milestone in progressing towards reliable determination of gas flux data from satellite-derived SO2 maps during volcanic eruptions, which would be of great value for operational management of explosive eruptions.

  5. A real time status monitor for transistor bank driver power limit resistor in boost injection kicker power supply

    SciTech Connect

    Mi, J.; Tan, Y.; Zhang, W.

    2011-03-28

    For years suffering of Booster Injection Kicker transistor bank driver regulator troubleshooting, a new real time monitor system has been developed. A simple and floating circuit has been designed and tested. This circuit monitor system can monitor the driver regulator power limit resistor status in real time and warn machine operator if the power limit resistor changes values. This paper will mainly introduce the power supply and the new designed monitoring system. This real time resistor monitor circuit shows a useful method to monitor some critical parts in the booster pulse power supply. After two years accelerator operation, it shows that this monitor works well. Previously, we spent a lot of time in booster machine trouble shooting. We will reinstall all 4 PCB into Euro Card Standard Chassis when the power supply system will be updated.

  6. Platelet-Rich Plasma Injections for Advanced Knee Osteoarthritis: A Prospective, Randomized, Double-Blinded Clinical Trial

    PubMed Central

    Joshi Jubert, Nayana; Rodríguez, Luciano; Reverté-Vinaixa, Maria Mercedes; Navarro, Aurora

    2017-01-01

    Background: Intra-articular injections of platelet-rich plasma (PRP) to treat symptoms of knee osteoarthritis (OA) have been successfully used in young patients and in the early stages of disease. No previous studies have analyzed outcomes of PRP injections during the late stages. Hypothesis: PRP reduces pain and leads to a more effective and lasting functional recovery than corticosteroid with local anesthetic. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 75 patients with symptomatic knee OA (Kellgren-Lawrence grade 3 to 4) were enrolled in this study between August 2013 and July 2014. Patients were randomized to treatment either with a single leukocyte-reduced PRP or corticosteroid intra-articular injection. The primary variable was visual analog scale assessment at 1 month. Secondary outcomes were the Knee injury and Osteoarthritis Outcome Score (KOOS) and Short Form–36 (SF-36) at 1, 3, and 6 months after treatment. Patient satisfaction at final follow-up was assessed. Both groups were homogeneous and comparable in baseline characteristics. Results: All variables improved in both groups. Statistical differences between groups were not found for the majority of the outcome variables, although the magnitude of improvements tended to be greater in the PRP group. Quality-of-life differences between values at 3 and 6 months versus baseline increased significantly more in the study group (P = .05 and .03, respectively), and so did general health perception differences at 6 months (P = .018). Conclusion: A single PRP intra-articular injection is effective for relieving pain and improving activities of daily living and quality of life in late-stage knee OA. For patients with late-stage knee OA who are 67 years or older, 1 intra-articular injection of PRP has similar results to 1 shot of corticosteroid. PMID:28255569

  7. PDMS glass serpentine microchannel chip for time domain PCR with bubble suppression in sample injection

    NASA Astrophysics Data System (ADS)

    Cho, Chul-Ho; Cho, Woong; Ahn, Yoomin; Hwang, Seung-Yong

    2007-09-01

    This paper reports on the development of a low-cost microreactor (10 µl) biochip for DNA polymerase chain reaction (PCR). The microbiochip (20 mm × 28 mm) is a hybrid type that is composed of a polydimethylsiloxane (PDMS) layer with a serpentine microchannel (360 µm × 100 µm) chamber and glass substrate integrated with a microheater and thermal microsensor. Because of the hydrophobic chip surface, bubbles are usually created during sample loading in the PMDS-based microchip. These bubbles disrupt the stable biochemical reaction. An improved microreactor chamber was designed using microfluidic simulation. The reactor has a rounded-corner serpentine channel architecture, which enables stable injection into the hydrophobic surface using only a micropipette. The reactor temperature needed for the PCR reaction is controlled within ±0.5 °C by the LabVIEW software proportional-integrative-derivative (PID) controller. PCR analyses of the sex-determining Y chromosome (SRY) gene and mouse GAPDH gene were successfully performed in less than 54 min by the fabricated microreactor chip.

  8. Time courses and time-resolved spectra of firefly bioluminescence initiated by two methods of ATP injection and photolysis of caged ATP.

    PubMed

    Yanagisawa, Yuki; Kageyama, Takeshi; Wada, Naohisa; Tanaka, Masatoshi; Ohno, Shin-Ya

    2013-01-01

    The time-dependent characteristics of firefly bioluminescence initiated by manual injection of adenosine triphosphate (ATP) into buffer solution containing luciferin (Ln), luciferase (Luc) and Mg(2+) were measured with a resolution of 10 ms, and compared with those obtained by photolysis of caged ATP. The time course depends on pH; both rise and decay rates decrease when pH is lowered from 7.8 to 6.8. In contrast, the parameter λ in the kinetic formula related to diffusion of ATP is almost independent of pH. The pH dependence of the time course of bioluminescence can be explained by the same pH tendency as the rate of ATP binding at the active site of Luc. The time-resolved spectra can be decomposed into two Gaussian components with maxima at 2.2 and 2.0 eV. At pH 7.8, the band at 2.2 eV is more intense than that at 2.0 eV for all three concentration conditions. At lower pH, the band at 2.2 eV becomes weaker than that at 2.0 eV. The intensity ratio of the 2.0 and 2.2 eV bands is constant for duration time of 600 s for both injection and photolysis experiments, and the above conclusions are unaffected by the concentration ratio [Ln]/[Luc].

  9. Reslizumab Injection

    MedlinePlus

    ... the infusion or for a short period of time after the infusion has finished.You will receive each injection of reslizumab in a doctor's office or medical facility. You will stay in the office for some time after you receive the medication so your doctor ...

  10. Time series geophysical monitoring of permanganate injections and in situ chemical oxidation of PCE, OU1 area, Savage Superfund Site, Milford, NH, USA

    USGS Publications Warehouse

    Harte, Philip T.; Smith, Thor E.; Williams, John H.; Degnan, James R.

    2012-01-01

    In situ chemical oxidation (ISCO) treatment with sodium permanganate, an electrically conductive oxidant, provides a strong electrical signal for tracking of injectate transport using time series geophysical surveys including direct current (DC) resistivity and electromagnetic (EM) methods. Effective remediation is dependent upon placing the oxidant in close contact with the contaminated aquifer. Therefore, monitoring tools that provide enhanced tracking capability of the injectate offer considerable benefit to guide subsequent ISCO injections. Time-series geophysical surveys were performed at a superfund site in New Hampshire, USA over a one-year period to identify temporal changes in the bulk electrical conductivity of a tetrachloroethylene (PCE; also called tetrachloroethene) contaminated, glacially deposited aquifer due to the injection of sodium permanganate. The ISCO treatment involved a series of pulse injections of sodium permanganate from multiple injection wells within a contained area of the aquifer. After the initial injection, the permanganate was allowed to disperse under ambient groundwater velocities. Time series geophysical surveys identified the downward sinking and pooling of the sodium permanganate atop of the underlying till or bedrock surface caused by density-driven flow, and the limited horizontal spread of the sodium permanganate in the shallow parts of the aquifer during this injection period. When coupled with conventional monitoring, the surveys allowed for an assessment of ISCO treatment effectiveness in targeting the PCE plume and helped target areas for subsequent treatment.

  11. Time series geophysical monitoring of permanganate injections and in situ chemical oxidation of PCE, OU1 area, Savage Superfund Site, Milford, NH, USA.

    PubMed

    Harte, Philip T; Smith, Thor E; Williams, John H; Degnan, James R

    2012-05-01

    In situ chemical oxidation (ISCO) treatment with sodium permanganate, an electrically conductive oxidant, provides a strong electrical signal for tracking of injectate transport using time series geophysical surveys including direct current (DC) resistivity and electromagnetic (EM) methods. Effective remediation is dependent upon placing the oxidant in close contact with the contaminated aquifer. Therefore, monitoring tools that provide enhanced tracking capability of the injectate offer considerable benefit to guide subsequent ISCO injections. Time-series geophysical surveys were performed at a superfund site in New Hampshire, USA over a one-year period to identify temporal changes in the bulk electrical conductivity of a tetrachloroethylene (PCE; also called tetrachloroethene) contaminated, glacially deposited aquifer due to the injection of sodium permanganate. The ISCO treatment involved a series of pulse injections of sodium permanganate from multiple injection wells within a contained area of the aquifer. After the initial injection, the permanganate was allowed to disperse under ambient groundwater velocities. Time series geophysical surveys identified the downward sinking and pooling of the sodium permanganate atop of the underlying till or bedrock surface caused by density-driven flow, and the limited horizontal spread of the sodium permanganate in the shallow parts of the aquifer during this injection period. When coupled with conventional monitoring, the surveys allowed for an assessment of ISCO treatment effectiveness in targeting the PCE plume and helped target areas for subsequent treatment.

  12. Time series geophysical monitoring of permanganate injections and in situ chemical oxidation of PCE, OU1 area, Savage Superfund Site, Milford, NH, USA

    NASA Astrophysics Data System (ADS)

    Harte, Philip T.; Smith, Thor E.; Williams, John H.; Degnan, James R.

    2012-05-01

    In situ chemical oxidation (ISCO) treatment with sodium permanganate, an electrically conductive oxidant, provides a strong electrical signal for tracking of injectate transport using time series geophysical surveys including direct current (DC) resistivity and electromagnetic (EM) methods. Effective remediation is dependent upon placing the oxidant in close contact with the contaminated aquifer. Therefore, monitoring tools that provide enhanced tracking capability of the injectate offer considerable benefit to guide subsequent ISCO injections. Time-series geophysical surveys were performed at a superfund site in New Hampshire, USA over a one-year period to identify temporal changes in the bulk electrical conductivity of a tetrachloroethylene (PCE; also called tetrachloroethene) contaminated, glacially deposited aquifer due to the injection of sodium permanganate. The ISCO treatment involved a series of pulse injections of sodium permanganate from multiple injection wells within a contained area of the aquifer. After the initial injection, the permanganate was allowed to disperse under ambient groundwater velocities. Time series geophysical surveys identified the downward sinking and pooling of the sodium permanganate atop of the underlying till or bedrock surface caused by density-driven flow, and the limited horizontal spread of the sodium permanganate in the shallow parts of the aquifer during this injection period. When coupled with conventional monitoring, the surveys allowed for an assessment of ISCO treatment effectiveness in targeting the PCE plume and helped target areas for subsequent treatment.

  13. Handbook II: Advanced Teaching Strategies for Adjunct and Part-Time Faculty.

    ERIC Educational Resources Information Center

    Greive, Donald E., Ed.

    This handbook is designed to help part-time and adjunct faculty who need professional enhancement but do not have the time for formal coursework. The focus is on the modern student, who differs in many ways from the traditional college student. The book provides more advanced strategies that those presented in the earlier "Handbook for…

  14. Time-Dependent Ballistic Phenomena of Electron Injected into Half-Ellipse Confined Room

    NASA Astrophysics Data System (ADS)

    Koiso, Takuji; Muraguchi, Masakazu; Takeda, Kyozaburo; Watanabe, Naoki

    2005-06-01

    We theoretically studied the time-developing ballistic phenomena of a single-electron confined in a half-ellipse infinite-potential wall by solving the time-dependent Schrödinger equation numerically. We also solved the corresponding Newton equation in order to compare the classical results with the quantum ones, and extracted the quantum features. The ellipse-shaped potential wall completely reflects an electron and causes the focusing ratio of unity in the classical limit. The dispersion of the wave packet of an electron, however, weakens this characteristic nature, and reduces the focusing ratio from unity. Because the dispersion also lets an electron arrive at the collector indistinctly, we define the effective arrival time by finding inflections in the time-dependent profile of the probability density at the collector. Based on the second-derivation technique, we further determine the quantum arrival time (QAT) at which the intrusion of the wave packet occurs dominantly. The comparison of this QAT with the classical arrival time (CAT) determines whether the corresponding ballistic propagation can be discussed on the basis of the quantum consideration or the classical prediction. We further studied how the change in the half-ellipse potential wall shape affects the ballistic phenomena through the change in the ellipticity γ, the system size L and the dispersion degree σ of the wave packet. Using the ellipse-shaped infinite-potential wall, the application of the magnetic field causes irrational cyclotron motion assisted by the ellipse potential, in addition to the rational cyclotron motions. The numerical solution of the time-dependent Schr\\"{o}dinger equation determines the unique cyclotron motion whose peculiarity is caused by the dispersion of the wave packet and is rarely predicted by the classical limit.

  15. Time-dependent injection of Oort Cloud comets into earth-crossing orbits

    SciTech Connect

    Fernandez, J.A.; Ip, W.H.

    1987-07-01

    The present consideration of close stellar encounter-induced modulations of the influx rate of Oort Cloud comets notes that comet showers sufficiently intense for emergence in cratering statistics are produced at 80-Myr intervals, on the assumption of an Oort Cloud heavy comet core. Numerical simulations of the time evolution of comet showers or bursts indicate that a long tail of residual shower comets follows the major event with an intensity of about 0.01 of the peak rate after 20-30 Myr, thereby suggesting that residual comet showers are primarily clustered in certain areas of the sky, rendering them observable at virtually any time. 33 references.

  16. Absorption and injection models for open time-dependent quantum systems

    NASA Astrophysics Data System (ADS)

    Traversa, F. L.; Zhan, Z.; Oriols, X.

    2014-08-01

    In the time-dependent simulation of pure states dealing with transport in open quantum systems, the initial state is located outside of the active region of interest. Using the superposition principle and the analytical knowledge of the free time evolution of such a state outside the active region, together with absorbing layers and remapping, a model for a very significant reduction of the computational burden associated with the numerical simulation of open time-dependent quantum systems is presented. The model is specially suited to study (many-particle and high-frequency effects) quantum transport, but it can also be applied to any other research field where the initial time-dependent pure state is located outside of the active region. From numerical simulations of open quantum systems described by the (effective mass) Schrödinger and (atomistic) tight-binding equations, a reduction of the computational burden of about two orders of magnitude for each spatial dimension of the domain with a negligible error is presented.

  17. Absolute Time Error Calibration of GPS Receivers Using Advanced GPS Simulators

    DTIC Science & Technology

    1997-12-01

    29th Annual Precise Time a d Time Interval (PTTI) Meeting ABSOLUTE TIME ERROR CALIBRATION OF GPS RECEIVERS USING ADVANCED GPS SIMULATORS E.D...DC 20375 USA Abstract Preche time transfer eq)er&nen& using GPS with t h e stabd?v’s under ten nanoseconh are common& being reported willrbr the... time transfer communily. Relarive calibrations are done by naeasurhg the time error of one GPS receiver versus a “known master refmence receiver.” Z?t

  18. Beam Injection into RHIC

    NASA Astrophysics Data System (ADS)

    Fischer, W.; Hahn, H.; Mackay, W. W.; Tsoupas, N.

    1997-05-01

    During the RHIC sextant test in January 1997 beam was injected into a sixth of one of the rings for the first time. We describe the injection zone and its bottlenecks, the application program to steer the beam and the injection kickers. We report on the commissioning of the injection systems and on measurements of the kickers.

  19. Rat Blastocysts from Nuclear Injection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells.

    PubMed

    Hara, Hiromasa; Goto, Teppei; Takizawa, Akiko; Sanbo, Makoto; Jacob, Howard J; Kobayashi, Toshihiro; Nakauchi, Hiromitsu; Hochi, Shinichi; Hirabayashi, Masumi

    2016-04-01

    Pronucleus-like vesicle formation following premature chromosome condensation (PCC) of the donor cell nucleus is the key event for successful generation of cloned rodents by nuclear transplantation (NT). However in rat cloning, this change is difficult to induce in enucleated recipient oocytes because of their inability to maintain maturation-promoting factor levels. In this study, intact oocytes retrieved from nuclear-visualized H2B-tdTomato knock-in rats were injected with Venus-labeled cell nuclei. Because the incidence of PCC under MG-132 treatment significantly increased with the culture period (0%, 10.8%, 36.8%, and 87.5% at 0, 0.5, 1, and 2 h postinjection, respectively), the metaphase plate of the oocyte was removed 1-2 h after the nuclear injection. The NT-derived rat zygotes (n = 748) were activated with ionomycin/cycloheximide and transferred into temporal host mothers, resulting in the harvest of three blastocysts (0.4%) with Venus fluorescence. Two blastocysts were examined for their potential to commit to NT-derived embryonic stem cells (ntESCs). One ntESC line was established successfully and found to be competent in terms of karyotype, stem cell marker expression, and pluripotency. In conclusion, time-lagged enucleation of visualized oocyte nuclei allows the PCC incidence of donor nuclei and generation of NT blastocysts, and the blastocysts can commit to germline-competent ntESCs.

  20. DESIGN AND IMPLEMENTATION OF A CO2 FLOOD UTILIZING ADVANCED RESERVOIR CHARACTERIZATION AND HORIZONTAL INJECTION WELLS IN A SHALLOW SHELF CARBONATE APPROACHING WATERFLOOD DEPLETION

    SciTech Connect

    K.J. Harpole; Ed G. Durrett; Susan Snow; J.S. Bles; Carlon Robertson; C.D. Caldwell; D.J. Harms; R.L. King; B.A. Baldwin; D. Wegener; M. Navarrette

    2002-09-01

    The purpose of this project was to economically design an optimum carbon dioxide (CO{sub 2}) flood for a mature waterflood nearing its economic abandonment. The original project utilized advanced reservoir characterization and CO{sub 2} horizontal injection wells as the primary methods to redevelop the South Cowden Unit (SCU). The development plans; project implementation and reservoir management techniques were to be transferred to the public domain to assist in preventing premature abandonment of similar fields. The Unit was a mature waterflood with water cut exceeding 95%. Oil must be mobilized through the use of a miscible or near-miscible fluid to recover significant additional reserves. Also, because the unit was relatively small, it did not have the benefit of economies of scale inherent in normal larger scale projects. Thus, new and innovative methods were required to reduce investment and operating costs. Two primary methods used to accomplish improved economics were use of reservoir characterization to restrict the flood to the higher quality rock in the unit and use of horizontal injection wells to cut investment and operating costs. The project consisted of two budget phases. Budget Phase I started in June 1994 and ended late June 1996. In this phase Reservoir Analysis, Characterization Tasks and Advanced Technology Definition Tasks were completed. Completion enabled the project to be designed, evaluated, and an Authority for Expenditure (AFE) for project implementation submitted to working interest owners for approval. Budget Phase II consisted of the implementation and execution of the project in the field. Phase II was completed in July 2001. Performance monitoring, during Phase II, by mid 1998 identified the majority of producing wells which under performed their anticipated withdrawal rates. Newly drilled and re-activated wells had lower offtake rates than originally forecasted. As a result of poor offtake, higher reservoir pressure was a concern

  1. Analysis of PV Advanced Inverter Functions and Setpoints under Time Series Simulation.

    SciTech Connect

    Seuss, John; Reno, Matthew J.; Broderick, Robert Joseph; Grijalva, Santiago

    2016-05-01

    Utilities are increasingly concerned about the potential negative impacts distributed PV may have on the operational integrity of their distribution feeders. Some have proposed novel methods for controlling a PV system's grid - tie inverter to mitigate poten tial PV - induced problems. This report investigates the effectiveness of several of these PV advanced inverter controls on improving distribution feeder operational metrics. The controls are simulated on a large PV system interconnected at several locations within two realistic distribution feeder models. Due to the time - domain nature of the advanced inverter controls, quasi - static time series simulations are performed under one week of representative variable irradiance and load data for each feeder. A para metric study is performed on each control type to determine how well certain measurable network metrics improve as a function of the control parameters. This methodology is used to determine appropriate advanced inverter settings for each location on the f eeder and overall for any interconnection location on the feeder.

  2. Electroencephalography when meditation advances: a case-based time-series analysis.

    PubMed

    Tsai, Jui-Feng; Jou, Shaw-Hwa; Cho, WenChun; Lin, Chieh-Min

    2013-11-01

    Increased alpha and theta activities in electroencephalography (EEG) have been found during various forms of meditation. However, advanced stage of meditation drew less attention to date. We aimed at exploring EEG characteristics during advanced meditation. Bilateral absolute alpha and theta EEG powers were recorded when a single meditator at rest, exercising breath meditation, and reaching the advanced meditative stage in 10 sessions of meditation. Averaged time-series data were analyzed using simulation modeling analysis to compare the powers during different meditative phases. During breath meditation, significantly higher activities compared with baseline were found only in bilateral theta (P = 0.0406, 0.0158 for left and right sides, respectively), but not in alpha (P = 0.1412, 0.0978 for left and right sides, respectively) bands. When meditation advanced, significantly increased activities were found both in bilateral alpha (P = 0.0218, 0.0258 for left and right sides, respectively) and theta (P = 0.0308, 0.0260 for left and right sides, respectively) bands compared against breath meditation. When advanced meditation compared against baseline, bilateral alpha (P = 0.0001, 0.0001 for left and right sides, respectively) and theta (P = 0.0001, 0.0001 for left and right sides, respectively) bands revealed significantly increased activities. Our findings support that internalized attention manifested as theta activity continuingly enhances significantly in sequential phases of meditation, while relaxation manifested as alpha activity is significant only after the advanced meditative phase is reached.

  3. Preliminary Seismic Time-lapse Results of the First Post-injection Monitoring at the Ketzin Pilot Site for CO2 Storage

    NASA Astrophysics Data System (ADS)

    Huang, Fei; Monika, Ivandic; Julin, Christopher; Lüth, Stefan; Bergmann, Peter

    2016-04-01

    Time-lapse surface seismic monitoring methods have proven to be notably successful in imaging the development of the CO2 plume injected into the 630-650 meters deep saline aquifer at the Ketzin pilot site. A 3D baseline survey was acquired in the autumn of 2005 prior to CO2 injection, followed by two 3D repeat surveys conducted in the same season of 2009 and 2012 after injection of about 22 and 61 kt of CO2, respectively. These repeat surveys showed that the CO2 plume was concentrated around the injection well with a preferred WNW propagating trend due to reservoir heterogeneity. The CO2 induced amplitude anomaly continued to grow with more CO2 injected into the reservoir. The CO2 injection ended on August 29, 2013 after a total of about 67 kt injected CO2. In the autumn of 2015, a third 3D repeat survey with a nominal fold of 25 was acquired during the post-injection phase. The acquisition was implemented with an identical template scheme and acquisition parameters as in the previous surveys. About 5500 source points were acquired during the 57 days of active acquisition. The same processing steps as used before were carried out from pre-stack to post-stack. In order to minimize changes unrelated to the site operations, cross-calibration was applied to the data. Preliminary results of the time-lapse analysis show that the obtained amplitude anomaly at the reservoir level is smaller in size than the one observed at the time of the second repeat survey. This may indicate that CO2 dissolution is active, especially east of the injection site, where permeability and flow rate appear to be lower. In comparison to the previous surveys, the maximum amplitude anomaly has moved towards the west, which is consistent with the previously observed propagating tendency of the CO2 plume within the reservoir. No CO2 leakage is observed within the overburden.

  4. The Role and Timing of Palliative Care in Supporting Persons with Intellectual Disability and Advanced Dementia

    ERIC Educational Resources Information Center

    McCarron, Mary; McCallion, Philip; Fahey-McCarthy, Elizabeth; Connaire, Kevin

    2011-01-01

    Aim: To better describe the role and timing of palliative care in supporting persons with intellectual disabilities and advanced dementia (AD). Background: Specialist palliative care providers have focused mostly on people with cancers. Working with persons with intellectual disabilities and AD offers opportunities to expand such palliative care…

  5. 48 CFR 1552.215-74 - Advanced understanding-uncompensated time.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 6 2013-10-01 2013-10-01 false Advanced understanding-uncompensated time. 1552.215-74 Section 1552.215-74 Federal Acquisition Regulations System ENVIRONMENTAL PROTECTION AGENCY CLAUSES AND FORMS SOLICITATION PROVISIONS AND CONTRACT CLAUSES Texts of Provisions...

  6. Geolocation of LTE Subscriber Stations Based on the Timing Advance Ranging Parameter

    DTIC Science & Technology

    2010-12-01

    timing advance range rings (From [8]). ..................6 Figure 3. Functional commonality between SC- FDMA and OFDMA signal chains (From [14... FDMA Single Carrier Frequency Division Multiple Access SDU Service Data Unit SS Subscriber Station SVD Singular Value Decomposition TA...uplink and downlink. They are single-carrier frequency-division multiple access (SC- FDMA ) and orthogonal frequency-division multiple access (OFDMA

  7. A system for accurate and automated injection of hyperpolarized substrate with minimal dead time and scalable volumes over a large range.

    PubMed

    Reynolds, Steven; Bucur, Adriana; Port, Michael; Alizadeh, Tooba; Kazan, Samira M; Tozer, Gillian M; Paley, Martyn N J

    2014-02-01

    Over recent years hyperpolarization by dissolution dynamic nuclear polarization has become an established technique for studying metabolism in vivo in animal models. Temporal signal plots obtained from the injected metabolite and daughter products, e.g. pyruvate and lactate, can be fitted to compartmental models to estimate kinetic rate constants. Modeling and physiological parameter estimation can be made more robust by consistent and reproducible injections through automation. An injection system previously developed by us was limited in the injectable volume to between 0.6 and 2.4ml and injection was delayed due to a required syringe filling step. An improved MR-compatible injector system has been developed that measures the pH of injected substrate, uses flow control to reduce dead volume within the injection cannula and can be operated over a larger volume range. The delay time to injection has been minimized by removing the syringe filling step by use of a peristaltic pump. For 100μl to 10.000ml, the volume range typically used for mice to rabbits, the average delivered volume was 97.8% of the demand volume. The standard deviation of delivered volumes was 7μl for 100μl and 20μl for 10.000ml demand volumes (mean S.D. was 9 ul in this range). In three repeat injections through a fixed 0.96mm O.D. tube the coefficient of variation for the area under the curve was 2%. For in vivo injections of hyperpolarized pyruvate in tumor-bearing rats, signal was first detected in the input femoral vein cannula at 3-4s post-injection trigger signal and at 9-12s in tumor tissue. The pH of the injected pyruvate was 7.1±0.3 (mean±S.D., n=10). For small injection volumes, e.g. less than 100μl, the internal diameter of the tubing contained within the peristaltic pump could be reduced to improve accuracy. Larger injection volumes are limited only by the size of the receiving vessel connected to the pump.

  8. A system for accurate and automated injection of hyperpolarized substrate with minimal dead time and scalable volumes over a large range☆

    PubMed Central

    Reynolds, Steven; Bucur, Adriana; Port, Michael; Alizadeh, Tooba; Kazan, Samira M.; Tozer, Gillian M.; Paley, Martyn N.J.

    2014-01-01

    Over recent years hyperpolarization by dissolution dynamic nuclear polarization has become an established technique for studying metabolism in vivo in animal models. Temporal signal plots obtained from the injected metabolite and daughter products, e.g. pyruvate and lactate, can be fitted to compartmental models to estimate kinetic rate constants. Modeling and physiological parameter estimation can be made more robust by consistent and reproducible injections through automation. An injection system previously developed by us was limited in the injectable volume to between 0.6 and 2.4 ml and injection was delayed due to a required syringe filling step. An improved MR-compatible injector system has been developed that measures the pH of injected substrate, uses flow control to reduce dead volume within the injection cannula and can be operated over a larger volume range. The delay time to injection has been minimized by removing the syringe filling step by use of a peristaltic pump. For 100 μl to 10.000 ml, the volume range typically used for mice to rabbits, the average delivered volume was 97.8% of the demand volume. The standard deviation of delivered volumes was 7 μl for 100 μl and 20 μl for 10.000 ml demand volumes (mean S.D. was 9 ul in this range). In three repeat injections through a fixed 0.96 mm O.D. tube the coefficient of variation for the area under the curve was 2%. For in vivo injections of hyperpolarized pyruvate in tumor-bearing rats, signal was first detected in the input femoral vein cannula at 3–4 s post-injection trigger signal and at 9–12 s in tumor tissue. The pH of the injected pyruvate was 7.1 ± 0.3 (mean ± S.D., n = 10). For small injection volumes, e.g. less than 100 μl, the internal diameter of the tubing contained within the peristaltic pump could be reduced to improve accuracy. Larger injection volumes are limited only by the size of the receiving vessel connected to the pump. PMID:24355621

  9. A system for accurate and automated injection of hyperpolarized substrate with minimal dead time and scalable volumes over a large range

    NASA Astrophysics Data System (ADS)

    Reynolds, Steven; Bucur, Adriana; Port, Michael; Alizadeh, Tooba; Kazan, Samira M.; Tozer, Gillian M.; Paley, Martyn N. J.

    2014-02-01

    Over recent years hyperpolarization by dissolution dynamic nuclear polarization has become an established technique for studying metabolism in vivo in animal models. Temporal signal plots obtained from the injected metabolite and daughter products, e.g. pyruvate and lactate, can be fitted to compartmental models to estimate kinetic rate constants. Modeling and physiological parameter estimation can be made more robust by consistent and reproducible injections through automation. An injection system previously developed by us was limited in the injectable volume to between 0.6 and 2.4 ml and injection was delayed due to a required syringe filling step. An improved MR-compatible injector system has been developed that measures the pH of injected substrate, uses flow control to reduce dead volume within the injection cannula and can be operated over a larger volume range. The delay time to injection has been minimized by removing the syringe filling step by use of a peristaltic pump. For 100 μl to 10.000 ml, the volume range typically used for mice to rabbits, the average delivered volume was 97.8% of the demand volume. The standard deviation of delivered volumes was 7 μl for 100 μl and 20 μl for 10.000 ml demand volumes (mean S.D. was 9 ul in this range). In three repeat injections through a fixed 0.96 mm O.D. tube the coefficient of variation for the area under the curve was 2%. For in vivo injections of hyperpolarized pyruvate in tumor-bearing rats, signal was first detected in the input femoral vein cannula at 3-4 s post-injection trigger signal and at 9-12 s in tumor tissue. The pH of the injected pyruvate was 7.1 ± 0.3 (mean ± S.D., n = 10). For small injection volumes, e.g. less than 100 μl, the internal diameter of the tubing contained within the peristaltic pump could be reduced to improve accuracy. Larger injection volumes are limited only by the size of the receiving vessel connected to the pump.

  10. A Low NO(x) Lean-Direct Injection, Multipoint Integrated Module Combuster Concept for Advanced Aircraft Gas Turbines

    NASA Technical Reports Server (NTRS)

    Tacina, Robert; Wey, Changlie; Laing, Peter; Mansour, Adel

    2002-01-01

    A low NO(x) emissions combustor has been demonstrated in flame-tube tests. A multipoint, lean-direct injection concept was used. Configurations were tested that had 25- and 36- fuel injectors in the size of a conventional single fuel injector. An integrated-module approach was used for the construction where chemically etched laminates, diffusion bonded together, combine the fuel injectors, air swirlers and fuel manifold into a single element. Test conditions were inlet temperatures up to 810 K, inlet pressures up to 2760 kPa, and flame temperatures up to 2100 K. A correlation was developed relating the NO(x) emissions with the inlet temperature, inlet pressure, fuel-air ratio and pressure drop. Assuming that 10 percent of the combustion air would be used for liner cooling and using a hypothetical engine cycle, the NO(x) emissions using the correlation from flame-tube tests were estimated to be less than 20 percent of the 1996 ICAO standard.

  11. Sequential injection analysis for automation of the Winkler methodology, with real-time SIMPLEX optimization and shipboard application.

    PubMed

    Horstkotte, Burkhard; Tovar Sánchez, Antonio; Duarte, Carlos M; Cerdà, Víctor

    2010-01-25

    A multipurpose analyzer system based on sequential injection analysis (SIA) for the determination of dissolved oxygen (DO) in seawater is presented. Three operation modes were established and successfully applied onboard during a research cruise in the Southern ocean: 1st, in-line execution of the entire Winkler method including precipitation of manganese (II) hydroxide, fixation of DO, precipitate dissolution by confluent acidification, and spectrophotometric quantification of the generated iodine/tri-iodide (I(2)/I(3)(-)), 2nd, spectrophotometric quantification of I(2)/I(3)(-) in samples prepared according the classical Winkler protocol, and 3rd, accurate batch-wise titration of I(2)/I(3)(-) with thiosulfate using one syringe pump of the analyzer as automatic burette. In the first mode, the zone stacking principle was applied to achieve high dispersion of the reagent solutions in the sample zone. Spectrophotometric detection was done at the isobestic wavelength 466 nm of I(2)/I(3)(-). Highly reduced consumption of reagents and sample compared to the classical Winkler protocol, linear response up to 16 mg L(-1) DO, and an injection frequency of 30 per hour were achieved. It is noteworthy that for the offline protocol, sample metering and quantification with a potentiometric titrator lasts in general over 5 min without counting sample fixation, incubation, and glassware cleaning. The modified SIMPLEX methodology was used for the simultaneous optimization of four volumetric and two chemical variables. Vertex calculation and consequent application including in-line preparation of one reagent was carried out in real-time using the software AutoAnalysis. The analytical system featured high signal stability, robustness, and a repeatability of 3% RSD (1st mode) and 0.8% (2nd mode) during shipboard application.

  12. Effect of vaccination with N-glycolyl GM3/VSSP vaccine by subcutaneous injection in patients with advanced cutaneous melanoma.

    PubMed

    Osorio, Marta; Gracia, Elias; Reigosa, Edmundo; Hernandez, Julio; de la Torre, Ana; Saurez, Giselle; Perez, Kirenia; Viada, Carmen; Cepeda, Meylán; Carr, Adriana; Avila, Yisel; Rodríguez, Migdalia; Fernandez, Luis E

    2012-01-01

    NeuGc-containing gangliosides have been described in melanoma cells and are an attractive target for cancer immunotherapy because they are minimally or not expressed in normal human tissues. Melanoma patients treated with a vaccine based on N-glycolyl gangliosides have shown benefit in progression free survival and overall survival. We conducted a multicenter Phase I/II clinical trial in patients with metastatic cutaneous melanoma treated with the N-gycolyl GM3/very-small-size proteoliposomes vaccine by the subcutaneous route. Selecting the optimal biological dose of the vaccine was the principal objective based on immunogenicity, efficacy, and safety results. Six dose levels were studied and the treatment schedule consisted of five doses administered every 2 weeks and then monthly until 15 doses had been given. Dose levels evaluated were 150, 300, 600, 900, 1200, and 1500 μg with five patients included in each dose level except the 900 μg dose (n = 10). Immunogenicity was determined by antibody titers generated in patients after vaccination. Antitumor effect was measured by response criteria of evaluation in solid tumors and safety was evaluated by common toxicity criteria of adverse events. The vaccine was safe and immunogenic at all doses levels. The most frequent adverse events related to vaccination were mild to moderate injection site reactions and flu-like symptoms. Vaccination induced specific anti-NeuGcGM3 immunoglobulin M and immunoglobulin G antibody responses in all patients. Disease control (objective response or stable disease) was obtained in 38.46% of patients. Global median overall survival was 20.20 months. Two patients achieved overall survival duration of about 4 and 5 years, respectively. The 900 μg dose resulted in overall survival duration of 19.40 months and was selected as the biological optimal dose.

  13. Injection rate control cam

    SciTech Connect

    Perr, J.P.; Liang, E.; Yu, R.C.; Ghuman, A.S.

    1990-10-16

    This patent describes a cam for controlling the injection rate of fuel in a fuel injection system of an engine. The fuel injection system including a cyclically operating unit injector having a body, an injector plunger mounted for reciprocating movement in the injector body between an advanced position and a retracted portion to pump into the engine during each cycle a variable quantity of fuel up to a maximum quantity under rated engine conditions, and a drive train for converting rotational movement of the cam into reciprocating movement of the pumping plunger depending on the profile of the cam. The cam profile comprises at least a plunger retraction segment and a plunger advancement segment for controlling the velocity if injector plunger retraction and advancement, respectively, the plunger advancement segment including a pre-injection subsequent shaped to cause an initial quantity of fuel to be injected into the engine during each cycle at rated engine conditions while the pre-injection subsegment is in contact with the drive train, and an injection subsegment following the pre-injection subsegment.

  14. Adaptive optics real time processing design for the advanced technology solar telescope

    NASA Astrophysics Data System (ADS)

    Richards, Kit

    2012-07-01

    The four meter Advanced Technology Solar Telescope (ATST) adaptive optics (AO) system will require at least twenty-four times the real time processing power as the Dunn Solar Telescope AO system. An FPGA solution for ATST AO real time processing is being pursued instead of the parallel DSP approach used for the Dunn AO76 system. An analysis shows FPGAs will have lower latency and lower hardware cost than an equivalent DSP solution. Interfacing to the proposed high speed camera and the deformable mirror will be simpler and have lower latency than with DSPs. This paper will discuss the current design and progress toward implementing the FPGA solution.

  15. Advanced X-Ray Timing Array Mission: Conceptual Spacecraft Design Study

    NASA Technical Reports Server (NTRS)

    Hopkins, R. C.; Johnson, L.; Thomas, H. D.; Wilson-Hodge, C. A.; Baysinger, M.; Maples, C. D.; Fabisinski, L.L.; Hornsby, L.; Thompson, K. S.; Miernik, J. H.

    2011-01-01

    The Advanced X-Ray Timing Array (AXTAR) is a mission concept for submillisecond timing of bright galactic x-ray sources. The two science instruments are the Large Area Timing Array (LATA) (a collimated instrument with 2-50-keV coverage and over 3 square meters of effective area) and a Sky Monitor (SM), which acts as a trigger for pointed observations of x-ray transients. The spacecraft conceptual design team developed two spacecraft concepts that will enable the AXTAR mission: A minimal configuration to be launched on a Taurus II and a larger configuration to be launched on a Falcon 9 or similar vehicle.

  16. Development of a real-time chemical injection system for air-assisted variable-rate sprayers

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A chemical injection system is an effective method to minimize chemical waste and reduce the environmental pollution in pesticide spray applications. A microprocessor controlled injection system implementing a ceramic piston metering pump was developed to accurately dispense chemicals to be mixed wi...

  17. The Efficacy of Brucea javanica Oil Emulsion Injection as Adjunctive Therapy for Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis

    PubMed Central

    Xu, Wei; Xu, Zhengyuan; Ye, Tong; Shi, Qionghua

    2016-01-01

    Purpose. To evaluate the efficacy of Brucea javanica oil emulsion injection (BJOEI) in patients with advanced non-small-cell lung cancer (NSCLC) during chemotherapy. Method. Electronic database of EMBASE and PubMed and the conference proceeding of ASCO, CNKI, CBMdisc, VIP, and Wanfang database were searched to select RCTs comparing BJOEI plus chemotherapy with chemotherapy alone in the treatment of advanced NSCLC, until June 1, 2016. Two reviewers independently performed the analysis according to the inclusion and exclusion criteria. Review Manager 5.3 and STATA 12.0 were employed for data analysis. Result. Twenty-one studies including 2234 cases were included. The pooled result indicated that there were significant differences in ORR (RR = 1.25; 95% CI: 1.14–1.36; P < 0.00001), improvement of QOL (RR = 1.87; 95% CI: 1.63–2.15; P < 0.00001), nausea and vomiting (RR = 0.67; 95% CI: 0.46–0.98; P = 0.04), leukopenia (RR = 0.63; 95% CI: 0.52–0.75; P < 0.00001), but there was no difference in thrombocytopenia (RR = 0.78; 95% CI: 0.49–1.23; P = 0.29). Begg's funnel plot and Egger's test indicated that no publication bias was found. The sensitivity analysis suggested the stability of the pooled result. Conclusion. The addition of BJOEI can enhance efficacy, improve QOL, and decrease incidence of nausea and vomiting and leukopenia for advanced NSCLC patients. However, higher quality RCTs are needed to further confirm this finding. PMID:28050192

  18. Flow injection mass spectral fingerprints demonstrate chemical differences in rio red grapefruit with respect to year, harvest time, and conventional versus organic farming

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Spectral fingerprints were acquired for Ruby Red grapefruit using direct injection-electrospray ionization with time-of-flight and ion trap mass spectrometry (DI-ESI-TOF-MS and DI-ESI-IT-MS). Rio Red grapefruits were harvested 3 times a year (early, mid, and late harvests) in 2005 and 2006 from con...

  19. Large-scale synthesis of the controlled-geometry carbon coils by the manipulation of the SF6 gas flow injection time.

    PubMed

    Eum, Jun-Ho; Kim, Sung-Hoon; Yi, Soung Soo; Jang, Kiwan

    2012-05-01

    Carbon coils could be synthesized using C2H2/H2 as source gases and SF6 as an incorporated additive gas under thermal chemical vapor deposition system. Nickel catalyst layer deposition and then hydrogen plasma pretreatment were performed prior to the carbon coils deposition reaction. According to the different reaction processes, the injection time of SF6 gas flow was varied. The characteristics (formation density, morphology, and geometry) of the deposited carbon coils on the substrates were investigated according to the different reaction processes. Finally, the large-scale synthesis of carbon coils and their geometry control could be achieved merely by manipulating SF6 gas flow injection time. Three cases growth aspects were proposed according to SF6 gas flow injection time in association with the fluorine's characteristics for etching the materials or enhancing the nucleation sites.

  20. Pb enamel biomarker: Deposition of pre- and postnatal Pb isotope injection in reconstructed time points along rat enamel transect

    SciTech Connect

    Rinderknecht, A.L.; Kleinman, M.T.; Ericson, J.E. . E-mail: jeericso@uci.edu

    2005-10-01

    Exposure to lead (Pb) as well as other heavy metals in the environment is still a matter of public health concern. The development of the enamel biomarker for heavy metal exposure assessment is designed to improve studies of dose-effect relationships to developmental anomalies, particularly embryonic dysfunctions, and to provide a time-specific recount of past exposures. The work presented in this paper demonstrates maternal transfer across the placental barrier of the enriched isotope {sup 206}Pb tracer to the enamel of the rat pup. Likewise, injections of {sup 204}Pb-enriched tracer in the neonate rat resulted in deposition of the tracer in the enamel histology as measured by secondary ion microprobe spectrometry. Through enamel, we were able to observe biological removal and assimilation of prenatal and postnatal tracers, respectively. This research demonstrates that enamel can be used as a biomarker of exposure to Pb and may illustrate the toxicokinetics of incorporating Pb into fetal and neonatal steady-state system processes. The biomarker technique, when completely developed, may be applied to cross-sectional and longitudinal epidemiological research.

  1. Interferon Beta-1b Injection

    MedlinePlus

    ... course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which ... interferon beta-1b injection at around the same time of day each time you inject it. Follow ...

  2. Peginterferon Beta-1a Injection

    MedlinePlus

    ... course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which ... peginterferon beta-1a injection at around the same time of day each time you inject it. Follow ...

  3. Beam injection into RHIC

    SciTech Connect

    Fischer, W.; Hahn, H.; MacKay, W.W.; Satogata, T.; Tsoupas, N.; Zhang, W.

    1997-07-01

    During the RHIC sextant test in January 1997 beam was injected into a sixth of one of the rings for the first time. The authors describe the injection zone and its bottlenecks. They report on the commissioning of the injection system, on beam based measurements of the kickers and the application program to steer the beam.

  4. Advanced filter banks and time interleaving for analog and digital conversion

    NASA Astrophysics Data System (ADS)

    Velazquez, Scott R.

    1999-10-01

    This paper presents a comparison of Advanced Filter Banks (AFB) and Time-Interleaving for high-speed, high-resolution conversion between analog and digital signals using a parallel array of converters. The AFB is an unconventional class of filter bank that employs both analog and digital signal processing. The AFB improves the speed and resolution of the conversion compared to the standard Time-Interleaved array conversion technique. Gain and phase mismatch errors are analyzed for both the AFB and Time-Interleaving architectures. The filters in the AFB isolate the converters in the array from each other and attenuate the effects of mismatches. In four-channel example systems analyzed in this paper, gain and phase errors are attenuated by 21 dB more in the AFB (with 30 dB stopband attenuation) than in the Time- Interleaved system. The AFB is capable of analog-to-digital conversion with 14-bit resolution and 400 MHz sample rate.

  5. Treatment of liver cancer of middle and advanced stages using ultrasound-guided percutaneous ethanol injection combined with radiofrequency ablation: A clinical analysis

    PubMed Central

    SUN, XUE; LI, RU; ZHANG, BOTAO; YANG, YUEJIE; CUI, ZHIFEI

    2016-01-01

    Liver cancer is a malignancy of the digestive system and has a high morbidity and mortality rate. Local intervention has become a viable option in identifying liver treatment. The aim of the present study was to analyze the clinical effects of treating liver cancer in middle and advanced stages using ultrasound-guided percutaneous ethanol injection (PEI) in tumors combined with radiofrequency ablation (RFA). A total of 100 patients with stage III–IV liver cancers were selected to participate in the study. Patients were divided into groups. In group A, treatment was initiated with PEI and after 1–2 weeks RFA was applied while in group B treatment was initiated with RFA and after 1–2 weeks PEI was applied. Patients in group C received PEI and RFA simultaneously. The clinical effects in the 3 groups were compared after 6-month follow ups. The volume of tumor ablation necrosis in group A was significantly greater than that in the groups B and C, while the size was significantly smaller compared to groups B and C after ablation. For group A, the complete ablation rate was significantly higher than that in groups B and C, and the differences were statistically significant (P<0.05). Liver damage indices, including raising levels of glutamic-pyruvic transaminase and total bilirubin, were significantly decreased in group A (P<0.05). The survival rate in group A was also significantly higher than in groups B and C (P<0.05). In conclusion, for patients with liver cancer in middle and advanced stages, the treatment method using PEI followed by RFA was more beneficial in terms of improving the tumor ablation rate, alleviating liver damages and increasing survival rates. PMID:26998128

  6. Combination of Light and Melatonin Time Cues for Phase Advancing the Human Circadian Clock

    PubMed Central

    Burke, Tina M.; Markwald, Rachel R.; Chinoy, Evan D.; Snider, Jesse A.; Bessman, Sara C.; Jung, Christopher M.; Wright, Kenneth P.

    2013-01-01

    Study Objectives: Photic and non-photic stimuli have been shown to shift the phase of the human circadian clock. We examined how photic and non-photic time cues may be combined by the human circadian system by assessing the phase advancing effects of one evening dose of exogenous melatonin, alone and in combination with one session of morning bright light exposure. Design: Randomized placebo-controlled double-blind circadian protocol. The effects of four conditions, dim light (∼1.9 lux, ∼0.6 Watts/m2)-placebo, dim light-melatonin (5 mg), bright light (∼3000 lux, ∼7 Watts/m2)-placebo, and bright light-melatonin on circadian phase was assessed by the change in the salivary dim light melatonin onset (DLMO) prior to and following treatment under constant routine conditions. Melatonin or placebo was administered 5.75 h prior to habitual bedtime and 3 h of bright light exposure started 1 h prior to habitual wake time. Setting: Sleep and chronobiology laboratory environment free of time cues. Participants: Thirty-six healthy participants (18 females) aged 22 ± 4 y (mean ± SD). Results: Morning bright light combined with early evening exogenous melatonin induced a greater phase advance of the DLMO than either treatment alone. Bright light alone and melatonin alone induced similar phase advances. Conclusion: Information from light and melatonin appear to be combined by the human circadian clock. The ability to combine circadian time cues has important implications for understanding fundamental physiological principles of the human circadian timing system. Knowledge of such principles is important for designing effective countermeasures for phase-shifting the human circadian clock to adapt to jet lag, shift work, and for designing effective treatments for circadian sleep-wakefulness disorders. Citation: Burke TM; Markwald RR; Chinoy ED; Snider JA; Bessman SC; Jung CM; Wright Jr KP. Combination of light and melatonin time cues for phase advancing the human circadian

  7. Cabazitaxel Injection

    MedlinePlus

    ... injection is used along with prednisone to treat prostate cancer (cancer of a male reproductive organ) that has ... cabazitaxel injection is usually used in men with prostate cancer. If used by pregnant women, cabazitaxel injection can ...

  8. Fondaparinux Injection

    MedlinePlus

    ... fondaparinux injection.Talk to your doctor about the risk of using fondaparinux injection. ... Fondaparinux injection is used to prevent deep vein thrombosis (DVT; a blood ... Xa inhibitors. It works by decreasing the clotting ability of the blood.

  9. Morphine Injection

    MedlinePlus

    Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate ( ... Morphine injection comes as a solution (liquid) to inject intramuscularly (into a muscle) or intravenously (into a ...

  10. Dexamethasone Injection

    MedlinePlus

    Dexamethasone injection is used to treat severe allergic reactions. It is used in the management of certain types of ... gastrointestinal disease, and certain types of arthritis. Dexamethasone injection is also used for diagnostic testing. Dexamethasone injection ...

  11. Romidepsin Injection

    MedlinePlus

    Romidepsin injection is used to treat cutaneous T-cell lymphoma (CTCL; a group of cancers of the immune system ... one other medication given by mouth or by injection. Romidepsin injection is in a class of medications ...

  12. Ondansetron Injection

    MedlinePlus

    Zofran® Injection ... Ondansetron injection is used to prevent nausea and vomiting caused by cancer chemotherapy and surgery. Ondansetron is in a ... medications: or any of the ingredients in ondansetron injection. Ask your pharmacist for a list of the ...

  13. Determination of Diclofenac on a Dysprosium Nanowire- Modified Carbon Paste Electrode Accomplished in a Flow Injection System by Advanced Filtering

    PubMed Central

    Daneshgar, Parandis; Norouzi, Parviz; Ganjali, Mohammad Reza; Dinarvand, Rasoul; Moosavi-Movahedi, Ali Akbar

    2009-01-01

    A new detection technique called Fast Fourier Transform Square-Wave Voltammetry (FFT SWV) is based on measurements of electrode admittance as a function of potential. The response of the detector (microelectrode), which is generated by a redox processes, is fast, which makes the method suitable for most applications involving flowing electrolytes. The carbon paste electrode was modified by nanostructures to improve sensitivity. Synthesized dysprosium nanowires provide a more effective nanotube-like surface [1-4] so they are good candidates for use as a modifier for electrochemical reactions. The redox properties of diclofenac were used for its determination in human serum and urine samples. The support electrolyte that provided a more defined and intense peak current for diclofenac determination was a 0.05 mol L−1 acetate buffer pH = 4.0. The drug presented an irreversible oxidation peak at 850 mV vs. Ag/AgCl on a modified nanowire carbon paste electrode which produced high current and reduced the oxidation potential by about 100 mV. Furthermore, the signal-to-noise ratio was significantly increased by application of a discrete Fast Fourier Transform (FFT) method, background subtraction and two-dimensional integration of the electrode response over a selected potential range and time window. To obtain the much sensivity the effective parameters such as frequency, amplitude and pH was optimized. As a result, CDL of 2.0 × 10−9 M and an LOQ of 5.0 × 10−9 M were found for the determination for diclofenac. A good recovery was obtained for assay spiked urine samples and a good quantification of diclofenac was achieved in a commercial formulation. PMID:22408485

  14. Advanced Time-Resolved Fluorescence Microscopy Techniques for the Investigation of Peptide Self-Assembly

    NASA Astrophysics Data System (ADS)

    Anthony, Neil R.

    The ubiquitous cross beta sheet peptide motif is implicated in numerous neurodegenerative diseases while at the same time offers remarkable potential for constructing isomorphic high-performance bionanomaterials. Despite an emerging understanding of the complex folding landscape of cross beta structures in determining disease etiology and final structure, we lack knowledge of the critical initial stages of nucleation and growth. In this dissertation, I advance our understanding of these key stages in the cross-beta nucleation and growth pathways using cutting-edge microscopy techniques. In addition, I present a new combined time-resolved fluorescence analysis technique with the potential to advance our current understanding of subtle molecular level interactions that play a pivotal role in peptide self-assembly. Using the central nucleating core of Alzheimer's Amyloid-beta protein, Abeta(16 22), as a model system, utilizing electron, time-resolved, and non-linear microscopy, I capture the initial and transient nucleation stages of peptide assembly into the cross beta motif. In addition, I have characterized the nucleation pathway, from monomer to paracrystalline nanotubes in terms of morphology and fluorescence lifetime, corroborating the predicted desolvation process that occurs prior to cross-beta nucleation. Concurrently, I have identified unique heterogeneous cross beta domains contained within individual nanotube structures, which have potential bionanomaterials applications. Finally, I describe a combined fluorescence theory and analysis technique that dramatically increases the sensitivity of current time-resolved techniques. Together these studies demonstrate the potential for advanced microscopy techniques in the identification and characterization of the cross-beta folding pathway, which will further our understanding of both amyloidogenesis and bionanomaterials.

  15. Magnetospheric Drift Resonance Effects on Local Time Asymmetry, Injection Events, and Moon Interactions for Saturn as Compared to Earth

    NASA Astrophysics Data System (ADS)

    Cooper, J. F.

    2005-05-01

    The magnetospheres of Earth and Saturn have similarities in terms of the highest energy radiation belt components from Cosmic Ray Albedo Neutron Decay (CRAND) but have otherwise been expected to differ on the role of charged particle convection driven by solar wind interactions with these magnetospheres. Saturn's inner and middle magnetosphere has been assumed to be dominated by corotation with little direct penetration by solar wind and magnetotail plasma. Since Saturn's planetary magnetic field characterized by the Z3 model is axisymmetric, although slightly offset northward from the ring plane, it has been difficult to understand previous Pioneer and Voyager measurements of local time asymmetry in energetic particle populations, including just outside the main rings as found by Pioneer 11. Small scale features (microsignatures) of charged particle absorption by Saturn moons and possible 'ghost' clouds of co-orbiting debris show no consistent patterns in the context of symmetric models for longitudinal drift shells. Since the 100-MeV CRAND proton drift shells are highly symmetric, it is apparent that lower energy electrons and ions showing substantial local time asymmetry are influenced by forces other than simple corotation. Cassini Huygens neutral atom observations show clear evidence of substorm injections reaching into the middle magnetosphere of Saturn preferentially on the nightside. One model would be that hot magnetotail plasma is convecting sunward into regions of colder plasma previously observed by Voyager, consistent with a dusk-to-dawn convective electric field. Numerical simulations of keV to MeV electron motion under such conditions, and with variability of upstream solar wind speed and magnetic field, show large perturbations of electron drift shells maximizing at energies of drift resonance where retrograde gradient-cuvature drift exactly cancels corotation for electrons at energies above several hundred keV. Averaged over many drift periods

  16. Assessing Uncertainty and Repeatability in Time-Lapse VSP Monitoring of CO2 Injection in a Brine Aquifer, Frio Formation, Texas (A Case Study)

    SciTech Connect

    Nazari, Siamak; Daley, Thomas M.

    2013-02-07

    This study was done to assess the repeatability and uncertainty of time-lapse VSP response to CO2 injection in the Frio formation near Houston Texas. A work flow was built to assess the effect of time-lapse injected CO2 into two Frio brine reservoir intervals, the ‘C’ sand (Frio1) and the ‘Blue sand’ (Frio2). The time-lapse seismic amplitude variations with sensor depth for both reservoirs Frio1 and Frio2 were computed by subtracting the seismic response of the base survey from each of the two monitor seismic surveys. Source site 1 has been considered as one of the best sites for evaluating the time-lapse response after injection. For site 1, the computed timelapse NRMS levels after processing had been compared to the estimated time-lapse NRMS level before processing for different control reflectors, and for brine aquifers Frio1, and Frio2 to quantify detectability of amplitude difference. As the main interest is to analyze the time-lapse amplitude variations, different scenarios have been considered. Three different survey scenarios were considered: the base survey which was performed before injection, monitor1 performed after the first injection operation, and monitor2 which was after the second injection. The first scenario was base-monitor1, the second was basemonitor2, and the third was monitor1-monitor2. We considered three ‘control’ reflections above the Frio to assist removal of overburden changes, and concluded that third control reflector (CR3) is the most favorable for the first scenario in terms of NRMS response, and first control reflector (CR1) is the most favorable for the second and third scenarios in terms of NRMS response. The NRMS parameter is shown to be a useful measure to assess the effect of processing on time-lapse data. The overall NRMS for the Frio VSP data set was found to be in the range of 30% to 80% following basic processing. This could be considered as an estimated baseline in assessing the utility

  17. The Chimera II Real-Time Operating System for advanced sensor-based control applications

    NASA Technical Reports Server (NTRS)

    Stewart, David B.; Schmitz, Donald E.; Khosla, Pradeep K.

    1992-01-01

    Attention is given to the Chimera II Real-Time Operating System, which has been developed for advanced sensor-based control applications. The Chimera II provides a high-performance real-time kernel and a variety of IPC features. The hardware platform required to run Chimera II consists of commercially available hardware, and allows custom hardware to be easily integrated. The design allows it to be used with almost any type of VMEbus-based processors and devices. It allows radially differing hardware to be programmed using a common system, thus providing a first and necessary step towards the standardization of reconfigurable systems that results in a reduction of development time and cost.

  18. Local-time Distribution of Low-latitute Ground Magnetic Disturbances at Sawtooth Injections of April 18-19, 2002

    NASA Astrophysics Data System (ADS)

    Kitamura, K.; Kawano, H.; Ohtani, S.; Yoshikawa, A.; Yumoto, K.

    2002-12-01

    A magnetic storm which occurred on April 17-19, 2002 has been studied to investigate a development of the ring current and the current structure which was set up during the magnetic storm. A Coronal Mass Ejection (CME) passed through the Earth on April 17, 2002, which caused an intense magnetic storm on the ground. The main phase of the magnetic storm started at 11 UT on April 17 and developed until 19 UT on April 18 with minimum Dst of -123 nT. On April 18, low energy electron flux observed by four LANL satellites showed quasi-periodic perturbations (2-3 h) in the energy range of 50-315keV: Events of this type has been called "saw-tooth" events. In the solar wind data from the ACE satellite, the IMF-Bz component was stable and southward (-10 nT) from 1 UT till 17 UT on April 18. On the other hand, magnetic variations on the ground showed Bay-like magnetic variations with amplitudes of 10-40 nT that were synchronized with particle injections observed by the LANL satellites. We have used magnetic data from 8 ground stations of the Circum-pan Magnetometer Network (CPMN) which are LMT (Mlat=-33.53 deg.), MUT (6.39), EWA (21.57), GAM (5.64), YAP (0.50), SMA (-19.82), LAQ (36.25) and HER (-42.12): They are widely separated in longitudinal direction in the middle and low latitudes. The Bay-like magnetic variations, which were synchronized with the particle injections, were predominant in the H-component, and showed similar waveforms at all stations. D-component variations were smaller than the H-component. Clear Pi 2 pulsations also appeared globally, corresponding to the above magnetic variations. We have so far studied the Pi 2 which occurred at 19:07 UT on April 18: In this case, each ground stations located at 04:30 MLT (LMT), 05:00 (MUT), 06:30 (GAM), 06:15 (YAP), 12:00 (EWA), 17:00 (SMA), 22:00 (LAQ) and 21:00 (HER). Amplitudes of the Pi 2s were large in the morning sector (> 1 nT) and weak at other local times (< 0.5 nT). We have calculated the directions of the

  19. A Proposal for an Advanced Drilling System with Real-Time Diagnostics (Diagnostics-While-Drilling)

    SciTech Connect

    Finger, J.T.; Mansure, A.J.; Prairie, M.R.

    1999-07-12

    In this paper, we summarize the rationale for an advanced system called Diagnostics-While-Drilling (DWD) and describe its benefits, preliminary configuration, and essential characteristics. The central concept is a closed data circuit in which downhole sensors collect information and send it to the surface via a high-speed data link, where it is combined with surface measurements and processed through drilling advisory software. The driller then uses this information to adjust the drilling process, sending control signals back downhole with real-time knowledge of their effects on performance. We outline a Program Plan for DOE, university, and industry to cooperate in the development of DWD technology.

  20. Development plan for an advanced drilling system with real-time diagnostics (Diagnostics-While-Drilling)

    SciTech Connect

    FINGER,JOHN T.; MANSURE,ARTHUR J.; PRAIRIE,MICHAEL R.; GLOWKA,D.A.

    2000-02-01

    This proposal provides the rationale for an advanced system called Diagnostics-while-drilling (DWD) and describes its benefits, preliminary configuration, and essential characteristics. The central concept is a closed data circuit in which downhole sensors collect information and send it to the surface via a high-speed data link, where it is combined with surface measurements and processed through drilling advisory software. The driller then uses this information to adjust the drilling process, sending control signals back downhole with real-time knowledge of their effects on performance. The report presents background of related previous work, and defines a Program Plan for US Department of Energy (DOE), university, and industry cooperation.

  1. Toward Integrated Operator Interface for Advanced Teleoperation under Time-Delay

    NASA Technical Reports Server (NTRS)

    Bejczy, Antal K.; Fiorini, Paolo; Kim, Won Soo; Schenker, Paul

    1994-01-01

    This paper briefly describes an Advanced Teleoperator (ATOP) system and its control station where a variety of computer-based operator interface devices and techniques are integrated into a functional setting, accommodating a primary operator and secondary operators. Computer graphics is a key operator interface component in the control station where new types of manual interface devices also are employed. The results of some generic and applications task experiments are summarized, including the performance of a simulated remote satellite servicing task, carried out under four to eight seconds communications time delay, using satellite TV and Internet computer communication links. In conclusion, the paper highlights the lessons learned so far,.

  2. Assessing the productivity of advanced practice providers using a time and motion study.

    PubMed

    Ogunfiditimi, Folusho; Takis, Lisa; Paige, Virginia J; Wyman, Janet F; Marlow, Elissa

    2013-01-01

    The Resource-Based Relative Value Scale is widely used to measure healthcare provider productivity and to set payment standards. The scale, however, is limited in its assessment of pre- and postservice work and other potentially non-revenue-generating healthcare services, what we have termed service-valued activity (SVA). In an attempt to quantify SVA, we conducted a time and motion study of providers to assess their productivity in inpatient and outpatient settings. Using the Standard Time and Motion Procedures checklist as a methodological guide, we provided personal digital assistants (PDAs) that were prepopulated with 2010 Current Procedural Terminology codes to 19 advanced practice providers (APPs). The APPs were instructed to identify their location and activity each time the PDA randomly alarmed. The providers collected data for 3 to 5 workdays, and those data were separated into revenue-generating services (RGSs) and SVAs. Multiple inpatient and outpatient departments were assessed. The inpatient APPs spent 61.6 percent of their time on RGSs and 35.1 percent on SVAs. Providers in the outpatient settings spent 59.0 percent of their time on RGSs and 38.2 percent on SVAs. This time and motion study demonstrated an innovative method and tool for the quantification and analysis of time spent on revenue- and non-revenue-generating services provided by healthcare professionals. The new information derived from this study can be used to accurately document productivity, determine clinical practice patterns, and improve deployment strategies of healthcare providers.

  3. The Effect of the Time of Injection of Intrathecal Analgesia on the Length of Early and Advanced Labor

    DTIC Science & Technology

    1999-10-01

    25 Calculation of Mean Length of Each Stage of Labor........................................................25 The Length of the Stages...Spreadsheet xi LIST OF TABLES Table 1. Mean Values of Various Components of Labor...............................................7 Table 2. Characteristics...30 xii LIST OF FIGURES Figure 1. Mean Length in Minutes of Each Stage of Labor..........................................27 Figure 2. The Length of

  4. Ibandronate Injection

    MedlinePlus

    Boniva® Injection ... Ibandronate injection is used to treat osteoporosis (a condition in which the bones become thin and weak and break ... Ibandronate injection comes as a solution (liquid) to be injected into a vein by a doctor or nurse in ...

  5. Leuprolide Injection

    MedlinePlus

    Leuprolide injection comes as a long-acting suspension (Lupron) that is injected intramuscularly (into a muscle) by a doctor or nurse in a medical ... Depot-4 month, Lupron Depot-6 Month). Leuprolide injection also comes as a long-acting suspension (Eligard) that is injected subcutaneously (just under ...

  6. Time-temperature-stress capabilities of composite materials for advanced supersonic technology application

    NASA Technical Reports Server (NTRS)

    Kerr, James R.; Haskins, James F.

    1987-01-01

    Advanced composites will play a key role in the development of the technology for the design and fabrication of future supersonic vehicles. However, incorporating the material into vehicle usage is contingent on accelerating the demonstration of service capacity and design technology. Because of the added material complexity and lack of extensive data, laboratory replication of the flight service will provide the most rapid method to document the airworthiness of advanced composite systems. Consequently, a laboratory program was conducted to determine the time-temperature-stress capabilities of several high temperature composites. Tests included were thermal aging, environmental aging, fatigue, creep, fracture, tensile, and real-time flight simulation exposure. The program had two phases. The first included all the material property determinations and aging and simulation exposures up through 10,000 hours. The second continued these tests up to 50,000 cumulative hours. This report presents the results of the Phase 1 baseline and 10,000-hr aging and flight simulation studies, the Phase 2 50,000-hr aging studies, and the Phase 2 flight simulation tests, some of which extended to almost 40,000 hours.

  7. Advanced Engine Health Management Applications of the SSME Real-Time Vibration Monitoring System

    NASA Technical Reports Server (NTRS)

    Fiorucci, Tony R.; Lakin, David R., II; Reynolds, Tracy D.; Turner, James E. (Technical Monitor)

    2000-01-01

    The Real Time Vibration Monitoring System (RTVMS) is a 32-channel high speed vibration data acquisition and processing system developed at Marshall Space Flight Center (MSFC). It Delivers sample rates as high as 51,200 samples/second per channel and performs Fast Fourier Transform (FFT) processing via on-board digital signal processing (DSP) chips in a real-time format. Advanced engine health assessment is achieved by utilizing the vibration spectra to provide accurate sensor validation and enhanced engine vibration redlines. Discrete spectral signatures (such as synchronous) that are indicators of imminent failure can be assessed and utilized to mitigate catastrophic engine failures- a first in rocket engine health assessment. This paper is presented in viewgraph form.

  8. Role of the advanced practice physiotherapist in decreasing surgical wait times.

    PubMed

    Aiken, Alice B; Harrison, Mark M; Hope, John

    2009-01-01

    The role of the advanced practice physiotherapist (APP) in outpatient orthopedic clinics has been present in Ontario for over five years. These professionals have additional duties beyond those of a regular physiotherapist in order to screen patients pre- and post-operatively, triage patients for surgery, prescribe conservative management and monitor patients on an ongoing basis. The purpose of this role is to improve patient access to timely surgical care by reducing wait times for hip and knee replacement surgeries. Several positive outcomes have been reported in the literature. It has been established that an APP can effectively manage over 30% of the patients referred to a surgeon for hip or knee replacement surgery because these patients do not require surgery; rather, they require conservative management.

  9. Time-temperature-stress capabilities of composite materials for advanced supersonic technology application, phase 1

    NASA Technical Reports Server (NTRS)

    Kerr, J. R.; Haskins, J. F.

    1980-01-01

    Implementation of metal and resin matrix composites into supersonic vehicle usage is contingent upon accelerating the demonstration of service capacity and design technology. Because of the added material complexity and lack of extensive service data, laboratory replication of the flight service will provide the most rapid method of documenting the airworthiness of advanced composite systems. A program in progress to determine the time temperature stress capabilities of several high temperature composite materials includes thermal aging, environmental aging, fatigue, creep, fracture, and tensile tests as well as real time flight simulation exposure. The program has two parts. The first includes all the material property determinations and aging and simulation exposures up through 10,000 hours. The second continues these tests up to 50,000 cumulative hours. Results are presented of the 10,000 hour phase, which has now been completed.

  10. MPACT FY2011 Advanced Time-Correlated Measurement Research at INL

    SciTech Connect

    D. L. Chichester; S. A. Pozzi; J. L. Dolan; M. Flaska; S. M. Watson

    2011-09-01

    Simulations and experiments have been carried out to investigate advanced time-correlated measurement methods for characterizing and assaying nuclear material for safeguarding the nuclear fuel cycle. These activities are part of a project studying advanced instrumentation techniques in support of the U.S. Department of Energy's Fuel Cycle Research and Development program and its Materials Protection, Accounting, and Control Technologies (MPACT) program. For fiscal year 2011 work focused on examining the practical experimental aspects of using a time-tagged, associated-particle electronic neutron generator for interrogating low-enrichment uranium in combination with steady-state interrogation using a moderated 241Am-Li neutron source. Simulation work for the project involved the use of the MCNP-PoliMi Monte Carlo simulation tool to determine the relative strength and the time-of-flight energy spectra of different sample materials under irradiation. Work also took place to develop a post-processor parser code to extract comparable data from the MCNP5&6 codes. Experiments took place using a commercial deuterium-tritium associated-particle electronic neutron generator to irradiate a number of uranium-bearing material samples. Time-correlated measurements of neutron and photon signatures of these measurements were made using five liquid scintillator detectors in a novel array, using high-speed waveform digitizers for data collection. This report summarizes the experiments that took place in FY2011, presents preliminary analyses that have been carried out to date for a subpart of these experiments, and describes future activities planned in this area. The report also describes support Idaho National Laboratory gave to Oak Ridge National Laboratory in 2011 to facilitate 2-dimensional imagery of mixed-oxide fuel pins for safeguards applications as a part of the MPACT program.

  11. Determination of optimal dosage and delay time for computed tomographic lymphography after percutaneous injection of Iohexol into popliteal lymph nodes in dogs.

    PubMed

    Chun, Hyeyoung; Cho, Hangmyo; Cheon, Haengbok; Kim, Juhyung; Kim, Taehun; Kang, Ji-Houn; Kim, Gonhyung; Lee, Youngwon; Choi, Hojung; Lee, Heechun; Chang, Dongwoo

    2009-07-01

    The purposes of this study were to determine the optimal dose and delay time for lymphography by injection of Iohexol into popliteal lymph nodes and to assess images of computed tomography by the established protocol. Three different doses (30, 60 and 90 mgI/kg) of water-soluble iodinated contrast medium were injected into 15 popliteal lymph nodes of 10 adult beagles, and fluoroscopy was performed. Filling and duration of contrast media and the number of visible ducts from popliteal lymph nodes to the thoracic duct and its branches were recorded. CT lymphography was performed, and the number of visible thoracic ducts was compared with that found by radiographic lymphography. Radiographs obtained between 130 and 800 seconds after injection of contrast medium provided a detailed view of the thoracic duct. The dose of 60 mgI/kg was determined to enable quality diagnostic imaging without extranodal leakage in radiographic lymphography. There was no significant difference in the number of thoracic ducts between the two modalities at each anatomic location. However, CT lymphography provided images of the thoracic duct with better spatial resolution and without superimposition of surrounding tissue. The present study provides an adequate delay time and injection for identification of the canine thoracic duct, and therefore, this technique could be applied to diagnosis of disease associated with chest lymphatic drainage.

  12. Numerical investigation on lithium transport in the edge plasma of EAST real-time- Li-injection experiments in the frame of BOUT + +

    NASA Astrophysics Data System (ADS)

    Li, N. M.; Sun, J. Z.; Wang, Z. H.; Xu, X. Q.; Sun, Z.; Wang, L.; Hu, J. S.; Wang, D. Z.

    2016-10-01

    Experimental observations on applications of Lithium (Li) have indicated that Li could benefit plasma performance. But all these call for further investigation on lithium transport. A simple model has been developed by reducing Braginskii's equations with assumed quasi-neutral condition for transport of Li species in the edge plasma in the EAST experiments of real-time Li aerosol injection and implemented in the frame of BOUT + + . The simulation results show that Li atoms propagate inwards continuously during the Li injection, and the propagating depth of Li atoms depends on both the local plasma conditions along its path and the Li injection velocity. It is also found that Li ions accumulate rapidly in the edge, and only a small fraction of Li species can transport cross the magnetic field into the core. In the poloidal direction, Li ions drift swiftly downwards along the field lines, and transport much faster at the high field side than at the low field side. The strong interaction between background plasma and Li ions plays a critical role in determining the edge plasma profile. It is found that real-time Li injection raises the plasma density in the pedestal region and reduces the plasma temperature, just as has been observed experimentally National Magnetic Confinement Fusion Science Program of China No. 2013GB107003, National Natural Science Foundation of China No. 11575039.

  13. Differentiation of Inflammatory from Fibrotic Ileal Strictures among Patients with Crohn's Disease through Analysis of Time-Intensity Curves Obtained after Microbubble Contrast Agent Injection.

    PubMed

    Quaia, Emilio; Gennari, Antonio Giulio; van Beek, Edwin J R

    2017-04-03

    The aim of the study described here was to assess whether the analysis of time-intensity curves obtained after microbubble contrast agent injection could differentiate inflammatory from fibrotic ileal strictures among patients with Crohn's disease. Sixty-five consecutive patients (40 male and 25 female; mean age ± SD, 42.2 ± 12.22 y) with stricture of the terminal ileal loop from Crohn's disease were scanned after microbubble injection. Time-intensity curves were obtained from quantitative analysis, and peak enhancement, rise time, time to peak, area under the time-intensity curve (AUC), AUC during wash-in (AUCWI) and AUC during wash-out (AUCWO) were compared between patients with inflammatory strictures and patients with fibrotic strictures. Inflammatory (n = 40) and fibrotic (n = 25) strictures differed (p < 0.05) in peak enhancement, wash-in rate, wash-in perfusion index, AUC, AUCWI and AUCWO. The quantitative analysis of small bowel wall contrast enhancement after microbubble contrast agent injection may differentiate inflammatory from fibrotic ileal strictures in patients with Crohn's disease.

  14. Advanced Kalman Filter for Real-Time Responsiveness in Complex Systems

    SciTech Connect

    Welch, Gregory Francis

    2014-06-10

    Complex engineering systems pose fundamental challenges in real-time operations and control because they are highly dynamic systems consisting of a large number of elements with severe nonlinearities and discontinuities. Today’s tools for real-time complex system operations are mostly based on steady state models, unable to capture the dynamic nature and too slow to prevent system failures. We developed advanced Kalman filtering techniques and the formulation of dynamic state estimation using Kalman filtering techniques to capture complex system dynamics in aiding real-time operations and control. In this work, we looked at complex system issues including severe nonlinearity of system equations, discontinuities caused by system controls and network switches, sparse measurements in space and time, and real-time requirements of power grid operations. We sought to bridge the disciplinary boundaries between Computer Science and Power Systems Engineering, by introducing methods that leverage both existing and new techniques. While our methods were developed in the context of electrical power systems, they should generalize to other large-scale scientific and engineering applications.

  15. An experimental study of fuel injection strategies in CAI gasoline engine

    SciTech Connect

    Hunicz, J.; Kordos, P.

    2011-01-15

    Combustion of gasoline in a direct injection controlled auto-ignition (CAI) single-cylinder research engine was studied. CAI operation was achieved with the use of the negative valve overlap (NVO) technique and internal exhaust gas re-circulation (EGR). Experiments were performed at single injection and split injection, where some amount of fuel was injected close to top dead centre (TDC) during NVO interval, and the second injection was applied with variable timing. Additionally, combustion at variable fuel-rail pressure was examined. Investigation showed that at fuel injection into recompressed exhaust fuel reforming took place. This process was identified via an analysis of the exhaust-fuel mixture composition after NVO interval. It was found that at single fuel injection in NVO phase, its advance determined the heat release rate and auto-ignition timing, and had a strong influence on NO{sub X} emission. However, a delay of single injection to intake stroke resulted in deterioration of cycle-to-cycle variability. Application of split injection showed benefits of this strategy versus single injection. Examinations of different fuel mass split ratios and variable second injection timing resulted in further optimisation of mixture formation. At equal share of the fuel mass injected in the first injection during NVO and in the second injection at the beginning of compression, the lowest emission level and cyclic variability improvement were observed. (author)

  16. [Near infrared spectroscopy on-line and real-time monitoring of alcohol precipitation process of reduning injection].

    PubMed

    Wang, Yong-Xiang; Mi, Hui-Juan; Zhang, Chuan-Li; Su, Guang; Bi, Yu-An; Wang, Zhen-Zhong; Xiao, Wei

    2014-12-01

    Near infrared (NIR) spectroscopy as a kind of rapid process analysis technology has been successfully applied in Chinese medicine pharmaceutical process. In this research, the technology was adopted to establish the rapid quantitative analysis models of main indicators from the Lonicera japonica and Artemisia annua alcohol precipitation process of Reduning injection. On-line NIR spectra of 142 samples from alcohol precipitation process were collected and the content of main indicators for each sample were detected through off-line HPLC. With eliminating outliers, determination of spectra pretreatment method and selecting optimal band, the NIR quantitative calibration model for each indicator was established using partial least squares (PLS). These models were used to predict the unknown samples from precipitation process of Reduning injection to achieve the goal of rapid detection. The results showed that the models were ideal. The correlation coefficients of models for neochlorogenic acid, chlorogenic acid, 4-O-caffeoylquinic acid and secoxyloganin were 0.973 872, 0.985 449, 0.975 509 and 0.979 790, respectively and their relative standard errors of prediction (RSEP) were 2.922 49%, 2.341 37%, 2.930 40% and 2.184 60%, respectively. This study indicated that the NIR quantitative calibration model showed good stability and precision, and it can be used in rapid quantitative detection of main indicators of efficacy in order to on-line monitor the alcohol precipitation process of Reduning injection.

  17. Recent advancements to study flowering time in almond and other Prunus species.

    PubMed

    Sánchez-Pérez, Raquel; Del Cueto, Jorge; Dicenta, Federico; Martínez-Gómez, Pedro

    2014-01-01

    Flowering time is an important agronomic trait in almond since it is decisive to avoid the late frosts that affect production in early flowering cultivars. Evaluation of this complex trait is a long process because of the prolonged juvenile period of trees and the influence of environmental conditions affecting gene expression year by year. Consequently, flowering time has to be studied for several years to have statistical significant results. This trait is the result of the interaction between chilling and heat requirements. Flowering time is a polygenic trait with high heritability, although a major gene Late blooming (Lb) was described in "Tardy Nonpareil." Molecular studies at DNA level confirmed this polygenic nature identifying several genome regions (Quantitative Trait Loci, QTL) involved. Studies about regulation of gene expression are scarcer although several transcription factors have been described as responsible for flowering time. From the metabolomic point of view, the integrated analysis of the mechanisms of accumulation of cyanogenic glucosides and flowering regulation through transcription factors open new possibilities in the analysis of this complex trait in almond and in other Prunus species (apricot, cherry, peach, plum). New opportunities are arising from the integration of recent advancements including phenotypic, genetic, genomic, transcriptomic, and metabolomics studies from the beginning of dormancy until flowering.

  18. Recent advancements to study flowering time in almond and other Prunus species

    PubMed Central

    Sánchez-Pérez, Raquel; Del Cueto, Jorge; Dicenta, Federico; Martínez-Gómez, Pedro

    2014-01-01

    Flowering time is an important agronomic trait in almond since it is decisive to avoid the late frosts that affect production in early flowering cultivars. Evaluation of this complex trait is a long process because of the prolonged juvenile period of trees and the influence of environmental conditions affecting gene expression year by year. Consequently, flowering time has to be studied for several years to have statistical significant results. This trait is the result of the interaction between chilling and heat requirements. Flowering time is a polygenic trait with high heritability, although a major gene Late blooming (Lb) was described in “Tardy Nonpareil.” Molecular studies at DNA level confirmed this polygenic nature identifying several genome regions (Quantitative Trait Loci, QTL) involved. Studies about regulation of gene expression are scarcer although several transcription factors have been described as responsible for flowering time. From the metabolomic point of view, the integrated analysis of the mechanisms of accumulation of cyanogenic glucosides and flowering regulation through transcription factors open new possibilities in the analysis of this complex trait in almond and in other Prunus species (apricot, cherry, peach, plum). New opportunities are arising from the integration of recent advancements including phenotypic, genetic, genomic, transcriptomic, and metabolomics studies from the beginning of dormancy until flowering. PMID:25071812

  19. Time controlled descent guidance algorithm for simulation of advanced ATC systems

    NASA Technical Reports Server (NTRS)

    Lee, H. Q.; Erzberger, H.

    1983-01-01

    Concepts and computer algorithms for generating time controlled four dimensional descent trajectories are described. The algorithms were implemented in the air traffic control simulator and used by experienced controllers in studies of advanced air traffic flow management procedures. A time controlled descent trajectory comprises a vector function of time, including position, altitude, and heading, that starts at the initial position of the aircraft and ends at touchdown. The trajectory provides a four dimensional reference path which will cause an aircraft tracking it to touchdown at a predetermined time with a minimum of fuel consumption. The problem of constructing such trajectories is divided into three subproblems involving synthesis of horizontal, vertical, and speed profiles. The horizontal profile is constructed as a sequence of turns and straight lines passing through a specified set of waypoints. The vertical profile consists of a sequence of level flight and constant descent angle segments defined by altitude waypoints. The speed profile is synthesized as a sequence of constant Mach number, constant indicated airspeed, and acceleration/deceleration legs. It is generated by integrating point mass differential equations of motion, which include the thrust and drag models of the aircraft.

  20. Advanced Automation for Ion Trap Mass Spectrometry-New Opportunities for Real-Time Autonomous Analysis

    NASA Technical Reports Server (NTRS)

    Palmer, Peter T.; Wong, C. M.; Salmonson, J. D.; Yost, R. A.; Griffin, T. P.; Yates, N. A.; Lawless, James G. (Technical Monitor)

    1994-01-01

    The utility of MS/MS for both target compound analysis and the structure elucidation of unknowns has been described in a number of references. A broader acceptance of this technique has not yet been realized as it requires large, complex, and costly instrumentation which has not been competitive with more conventional techniques. Recent advancements in ion trap mass spectrometry promise to change this situation. Although the ion trap's small size, sensitivity, and ability to perform multiple stages of mass spectrometry have made it eminently suitable for on-line, real-time monitoring applications, advance automation techniques are required to make these capabilities more accessible to non-experts. Towards this end we have developed custom software for the design and implementation of MS/MS experiments. This software allows the user to take full advantage of the ion trap's versatility with respect to ionization techniques, scan proxies, and ion accumulation/ejection methods. Additionally, expert system software has been developed for autonomous target compound analysis. This software has been linked to ion trap control software and a commercial data system to bring all of the steps in the analysis cycle under control of the expert system. These software development efforts and their utilization for a number of trace analysis applications will be described.

  1. A day at a time: caregiving on the edge in advanced COPD

    PubMed Central

    Simpson, A Catherine; Young, Joanne; Donahue, Margaret; Rocker, Graeme

    2010-01-01

    The human cost of advanced chronic obstructive pulmonary disease (COPD) for informal caregivers in Canada is mostly unknown. Formal care is episodic, and informal caregivers provide the bulk of care between exacerbations. While patients fear becoming burdensome to family, we lack relevant data against which to assess the validity of this fear. The purpose of our qualitative study was to better understand the extent and nature of ‘burden’ experienced by informal caregivers in advanced COPD. The analysis of 14 informal caregivers interviews yielded the global theme ‘a day at a time,’ reflecting caregivers’ approach to the process of adjusting/coping. Subthemes were: loss of intimate relationship/identity, disease-related demands, and coping-related factors. Caregivers experiencing most distress described greater negative impact on relational dynamics and identity, effects they associated with increasing illness demands especially care recipients’ difficult, emotionally controlling attitudes/behaviors. Our findings reflect substantial caregiver vulnerability in terms of an imbalance between burden and coping capacity. Informal caregivers provide necessary, cost-effective care for those living with COPD and/or other chronic illness. Improved understanding of the physical, emotional, spiritual, and relational factors contributing to their vulnerability can inform new chronic care models better able to support their efforts. PMID:20631814

  2. ANTIGEN-SPECIFIC T LYMPHOCYTE PROLIFERATION DECREASES OVER TIME IN ADVANCED CHRONIC HEPATITIS C

    PubMed Central

    Morishima, Chihiro; Di Bisceglie, Adrian M.; Rothman, Alan L.; Bonkovsky, Herbert L.; Lindsay, Karen L.; Lee, William M.; Koziel, Margaret James; Fontana, Robert J.; Kim, Hae-Young; Wright, Elizabeth C.

    2011-01-01

    To evaluate T cell immunity in advanced liver disease, antigen-specific lymphoproliferative responses were prospectively studied in the context of the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) trial. Peripheral blood responses to HCV, tetanus and Candida protein antigens were measured at baseline, Month 12 (M12), M24, M36 and M48 in 186 patients randomized to either low-dose PEG-IFN only or observation. Liver histology was evaluated at baseline, M24 and M48. Patients with cirrhosis (Ishak 5–6) were less likely to have positive lymphoproliferative responses to HCV at baseline than patients with fibrosis (15% vs 29%, p=0.03) and had lower levels of HCV c100 responses at baseline, M24 and M48 (p=0.11, p=0.05, p=0.02, respectively). For 97 patients with complete longitudinal data, the frequency of positive lymphoproliferative responses to HCV, tetanus and Candida antigens declined over time (p<0.003) and the slope of this decline was greater in the PEG-IFN treatment group than the observation group (p < 0.02). Lower levels of tetanus lymphoproliferative responses were associated with fibrosis progression and clinical outcomes (p=0.009). Poorer CD4+ T cell proliferative function is associated with more advanced liver disease in chronic hepatitis C, and may be further affected by long-term PEG-IFN treatment. PMID:22571902

  3. Improving the timing of middle Holocene retreat and late Holocene advance of Jakobshavn Isbrae, Greenland

    NASA Astrophysics Data System (ADS)

    Briner, J. P.; Stewart, H. A.; Young, N. E.; Csatho, B.; Axford, Y.

    2009-04-01

    The Greenland Ice Sheet is undergoing dramatic change. How the ice sheet continues to respond to climate change has important ramifications for global climate and sea level rise, but the observation-based record of ice sheet change is extremely short. We use glacial-geologic techniques to determine the behavior of the Greenland Ice Sheet over longer timescales. In particular, we focus on the Holocene history of Jakobshavn Isbrae, one of the key ice streams on Greenland that is responsible for disproportionate mass loss of the Greenland Ice Sheet. Radiocarbon ages from basal lake sediments and 10Be exposure ages of bedrock spanning from the present ice margin to Disko Bugt, ~50 km west, reveal rapid deglaciation between ~8 and ~7 ka. After ~7 ka, the ice margin continued to retreat inland behind its present position. Although it is difficult to reconstruct how far inland the ice margin retreated, the Little Ice Age advance reworked marine bivalves that date from 2.2 to 6.1 ka (Weidick and Bennike, 2007). The bivalve ages indicate that the ice margin was behind its Little Ice Age position between ~6 and ~2 ka, and that its Neoglacial advance post-dates ~2 ka. We improve the timing of the Neoglacial advance of Jakobshavn Isbrae by collecting sediment cores from lakes that are beyond the Little Ice Age margin but close enough to receive ice sheet meltwater during the Little Ice Age advance. The sediments in these "threshold" lakes contain distinct units of varved sediments (representing a proglacial environment) that sharply overlie gyttja (representing a non-glacial environment). Four radiocarbon ages of the sedimentary contacts from three different lake sites range from 530±10 to 370±60 cal yr BP (1410-1640 AD), and reveal when Jakobshavn Isbrae neared its maximum Little Ice Age margin. Furthermore, the lake sediments reveal that between early Holocene deglaciation and the Little Ice Age, Jakobshavn Isbrae never spilled into these lake basins, indicating that the

  4. Interferon Alfa-2b Injection

    MedlinePlus

    ... medication either subcutaneously or intramuscularly three times a week. HBV, inject the medication either subcutaneously or intramuscularly three times a week usually for 16 weeks. hairy cell leukemia, inject ...

  5. Impact of injected dose and acquisition time on a normal database by use of 3D-SSP in SPECT images: quantitative simulation studies.

    PubMed

    Onishi, Hideo; Hatazawa, Jun; Nakagawara, Jyoji; Ito, Kengo; Ha-Kawa, Sang Kil; Masuda, Yasuhiko; Sugibayashi, Keiichi; Takahashi, Masaaki; Kikuchi, Kei; Katsuta, Noboru

    2015-07-01

    The present study aimed to validate the accuracy of normal databases (NDBs) with respect to variable injected doses and acquisition times by use of three-dimensional stereotactic surface projections (3D-SSP) in N-isopropyl-p-[123I]-iodoamphetamine (I-123-IMP) brain perfusion images. We constructed NDBs based on brain SPECT images obtained from 29 healthy volunteers. Each NDB was rebuilt under simulated unique conditions by use of dynamic acquisition datasets and comprised injected doses (222, 167, and 111 MBq) and acquisition times (30, 20, and 15 min). We selected seven of 29 datasets derived from the volunteers to simulate patients' data (PD). The simulated PD were designed to include regions of hypoperfusion. The study comprised protocol A (same conditions for PD and NDB) and protocol B (mismatched conditions for PD and NDB). We used 3D-SSP to compare with the Z score and detection error. The average Z scores were decreased significantly in protocol A [PD (High)-NDB (High) vs. PD (Low)-NDB (Low); PD (30 m)-NDB (30 m) vs. PD (15 m)-NDB (15 m) and PD (20 m)-NDB (20 m)].The average Z scores of PD (High) and PD (Medium) with NDB (High) did not differ significantly in protocol B, whereas all others were decreased significantly. The error of detection increased 6.65 % (protocol A) and 32.05 % (protocol B). The Z scores were specific to the injected dose and acquisition time used in 3D-SSP studies, and the calculated Z scores were affected by mismatched injected doses and acquisition times between PD and selected NDBs.

  6. Golimumab Injection

    MedlinePlus

    ... body and causes pain, swelling, and damage) including: rheumatoid arthritis (condition in which the body attacks its own ... doctor.If golimumab injection is used to treat rheumatoid arthritis, it may also be injected intravenously (into a ...

  7. Adalimumab Injection

    MedlinePlus

    ... causes pain, swelling, and damage) including the following: rheumatoid arthritis (a condition in which the body attacks its ... If you are using adalimumab injection to treat rheumatoid arthritis, your doctor may tell you to inject the ...

  8. Aripiprazole Injection

    MedlinePlus

    ... aripiprazole injection and aripiprazole extended-release injection developed gambling problems or other intense urges or behaviors that ... even if you do not realize that your gambling or any other intense urges or unusual behaviors ...

  9. Teduglutide Injection

    MedlinePlus

    ... mix and inject it.Teduglutide comes as a kit containing vials of teduglutide powder for injection, prefilled syringes containing diluent (liquid to be mixed with teduglutide powder), needles to attach to the diluent syringe, dosing syringes ...

  10. Cyclosporine Injection

    MedlinePlus

    ... injection is used with other medications to prevent transplant rejection (attack of the transplanted organ by the ... people who have received kidney, liver, and heart transplants. Cyclosporine injection should only be used to treat ...

  11. Colistimethate Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria. Colistimethate injection is in a class of medications called antibiotics. It works by killing bacteria.Antibiotics such as colistimethate injection will not work ...

  12. Chloramphenicol Injection

    MedlinePlus

    ... treat certain types of serious infections caused by bacteria when other antibiotics cannot be used. Chloramphenicol injection ... antibiotics. It works by stopping the growth of bacteria..Antibiotics such as chloramphenicol injection will not work ...

  13. Estrogen Injection

    MedlinePlus

    ... forms of estrogen injection are used to treat hot flushes (hot flashes; sudden strong feelings of heat and sweating) ... If you are using estrogen injection to treat hot flushes, your symptoms should improve within 1 to ...

  14. Medroxyprogesterone Injection

    MedlinePlus

    ... Medroxyprogesterone injection is a very effective method of birth control but does not prevent the spread of human ... you have been using a different method of birth control and are switching to medroxyprogesterone injection, your doctor ...

  15. Etanercept Injection

    MedlinePlus

    ... areas causing pain and joint damage), chronic plaque psoriasis (a skin disease in which red, scaly patches ... etanercept injection is used to treat chronic plaque psoriasis, it may be injected twice a week during ...

  16. Levoleucovorin Injection

    MedlinePlus

    Levoleucovorin injection is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall) when methotrexate is used to to treat certain types of cancer. Levoleucovorin injection is also used to treat people ...

  17. Leucovorin Injection

    MedlinePlus

    Leucovorin injection is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to to treat certain types of cancer. Leucovorin injection is used to ...

  18. Teniposide Injection

    MedlinePlus

    ... in men. You should not become pregnant or breast-feed while you are receiving teniposide injection. If you or your partner become pregnant while receiving teniposide injection, call your doctor. Teniposide may harm the fetus.

  19. Ipilimumab Injection

    MedlinePlus

    ... are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving ipilimumab injection, call your doctor. Ipilimumab injection may cause your baby to be born too early or to die before birth.

  20. Pralatrexate Injection

    MedlinePlus

    Pralatrexate injection is used to treat peripheral T-cell lymphoma (PTCL; a form of cancer that begins in a ... come back after treatment with other medications. Pralatrexate injection has not been shown to help people who ...

  1. Cyanocobalamin Injection

    MedlinePlus

    Cyanocobalamin injection is used to treat and prevent a lack of vitamin B12 that may be caused by any ... organs) and permanent damage to the nerves. Cyanocobalamin injection also may be given as a test to ...

  2. Paclitaxel Injection

    MedlinePlus

    Paclitaxel injection manufactured with human albumin is used to treat breast cancer that has not improved or that has come back after treatment with other medications. Paclitaxel injection manufactured with polyoxyethylated castor oil is used to ...

  3. Diphenhydramine Injection

    MedlinePlus

    Diphenhydramine injection is used to treat allergic reactions, especially for people who are unable to take diphenhydramine by mouth. ... is used also to treat motion sickness. Diphenhydramine injection is also used alone or along with other ...

  4. Peramivir Injection

    MedlinePlus

    Peramivir injection is used to treat some types of influenza infection ('flu') in people who have had symptoms of ... flu for no longer than 2 days. Peramivir injection is in a class of medications called neuraminidase ...

  5. Cefotetan Injection

    MedlinePlus

    Cefotetan injection is used to treat infections of the lungs, skin, bones, joints, stomach area, blood, female reproductive organs, and urinary tract. Cefotetan injection is also used before surgery to prevent infections. ...

  6. Mipomersen Injection

    MedlinePlus

    Mipomersen injection is used to decrease levels of cholesterol and other fatty substances in the blood in people who ... that removes LDL from the blood), but mipomersen injection should not be used along with this treatment. ...

  7. Romiplostim Injection

    MedlinePlus

    Romiplostim injection is used to increase the number of platelets (cells that help the blood to clot) in order ... low number of platelets in the blood). Romiplostim injection should only be used in people who cannot ...

  8. Hydrocortisone Injection

    MedlinePlus

    Hydrocortisone injection is used to treat symptoms of low corticosteroid levels (lack of certain substances that are usually produced ... also used to treat severe allergic reactions. Hydrocortisone injection is used in the management of multiple sclerosis ( ...

  9. Palivizumab Injection

    MedlinePlus

    Palivizumab injection is used to help prevent respiratory syncytial virus (RSV; common virus that can cause serious lung infections) ... or have certain heart or lung diseases. Palivizumab injection is not used to treat the symptoms of ...

  10. Naltrexone Injection

    MedlinePlus

    Naltrexone injection is used along with counseling and social support to help people who have stopped drinking large amounts of alcohol to avoid drinking again. Naltrexone injection is also used along with counseling and social ...

  11. Tesamorelin Injection

    MedlinePlus

    Tesamorelin injection is used to decrease the amount of extra fat in the stomach area in adults with human ... fat in certain areas of the body). Tesamorelin injection is not used to help with weight loss. ...

  12. Testosterone Injection

    MedlinePlus

    ... and testosterone pellet (Testopel) are forms of testosterone injection used to treat symptoms of low testosterone in ... are low before you begin to use testosterone injection. Testosterone enanthate (Delatestryl) and testosterone pellet (Testopel) are ...

  13. Tigecycline Injection

    MedlinePlus

    Tigecycline injection used to treat certain serious infections including community acquired pneumonia (a lung infection that developed in a ... area between the chest and the waist). Tigecycline injection should not be used to treat pneumonia that ...

  14. Eculizumab Injection

    MedlinePlus

    Eculizumab injection is used to treat paroxysmal nocturnal hemoglobinuria (PNH: a type of anemia in which too many red ... oxygen to all parts of the body). Eculizumab injection is also used to treat atypical hemolytic uremic ...

  15. Pembrolizumab Injection

    MedlinePlus

    Pembrolizumab injection is used to treat melanoma (a type of skin cancer) that cannot be treated with surgery or ... spread to other parts of the body. Pembrolizumab injection is also used to treat a certain type ...

  16. Methylprednisolone Injection

    MedlinePlus

    ... allergic reactions. Methylprednisolone injection is used in the management of multiple sclerosis (a disease in which the ... laboratory test, tell your doctor and the laboratory personnel that you are using methylprednisolone injection.If you ...

  17. Obinutuzumab Injection

    MedlinePlus

    Obinutuzumab injection is used with chlorambucil (Leukeran) to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells). Obinutuzumab injection is in a class of medications called ...

  18. Institutional Advancement Strategies in Hard Times. AAHE-ERIC/Higher Education Research Report No. 2.

    ERIC Educational Resources Information Center

    Richards, Michael D.; Sherratt, Gerald R.

    The historical role of institutional advancement and the specific activities and trends currently affecting it are reviewed, and four strategies for advancement programs are suggested. Institutional advancement includes alumni relations, fund-raising, public relations, internal and external communications, and government relations, and its…

  19. Recent advances in real-time analysis of ionograms and ionospheric drift measurements with digisondes

    NASA Astrophysics Data System (ADS)

    Reinisch, B. W.; Huang, X.; Galkin, I. A.; Paznukhov, V.; Kozlov, A.

    2005-08-01

    Reliable long distance RF communication and transionospheric radio links depend critically on space weather, and specifically ionospheric conditions. Modern ground-based ionosondes provide space weather parameters in real-time including the vertical electron density distribution up to ˜1000 km and the velocity components of the ionospheric F region drift. A global network of digisondes distributes this information in real-time via internet connections. The quality of the automatic scaling of the echo traces in ionograms was a continuous concern ever since first attempts have been reported. The modern low-power ionosonde with ˜100 W transmitters (compared to several kilowatt for the older ionosondes) relies on more sophisticated signal processing to enhance the signal-to-noise ratio and to retrieve the essential ionospheric characteristics. Recent advances in the automatic scaling algorithm ARTIST have significantly increased the reliability of the autoscaled data, making the data, in combination with models, more useful for ionospheric now-casting. Vertical and horizontal F region drift velocities are a new real-time output of the digisondes. The “ionosonde drift” is derived from the measured Doppler frequency shift and angle of arrival of ionospherically reflected HF echoes, a method similar to that used by coherent VHF and incoherent scatter radars.

  20. A system for advanced real-time visualization and monitoring of MR-guided thermal ablations

    NASA Astrophysics Data System (ADS)

    Rothgang, Eva; Gilson, Wesley D.; Hornegger, Joachim; Lorenz, Christine H.

    2010-02-01

    In modern oncology, thermal ablations are increasingly used as a regional treatment option to supplement systemic treatment strategies such as chemotherapy and immunotherapy. The goal of all thermal ablation procedures is to cause cell death of disease tissue while sparing adjacent healthy tissue. Real-time assessment of thermal damage is the key to therapeutic efficiency and safety of such procedures. Magnetic resonance thermometry is capable of monitoring the spatial distribution and temporal evolution of temperature changes during thermal ablations. In this work, we present an advanced monitoring system for MR-guided thermal ablations that includes multiplanar visualization, specialized overlay visualization methods, and additional methods for correcting errors resulting from magnetic field shifts and motion. To ensure the reliability of the displayed thermal data, systematic quality control of thermal maps is carried out on-line. The primary purpose of this work is to provide clinicians with an intuitive tool for accurately visualizing the progress of thermal treatment at the time of the procedure. Importantly, the system is designed to be independent of the heating source. The presented system is expected to be of great value not only to guide thermal procedures but also to further explore the relationship between temperature-time exposure and tissue damage. The software application was implemented within the eXtensible Imaging Platform (XIP) and has been validated with clinical data.

  1. Busulfan Injection

    MedlinePlus

    Busulfex® Injection ... Busulfan injection is used to treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of ... of 16 doses) before bone marrow transplant.Busulfan injection may cause seizures during therapy with the medication. ...

  2. Time Course Analysis of the Effects of Botulinum Neurotoxin Type A on Pain and Vasomotor Responses Evoked by Glutamate Injection into Human Temporalis Muscles

    PubMed Central

    Bittencourt da Silva, Larissa; Kulas, Dolarose; Karshenas, Ali; Cairns, Brian E.; Bach, Flemming W.; Arendt-Nielsen, Lars; Gazerani, Parisa

    2014-01-01

    The effect of botulinum neurotoxin type A (BoNTA) on glutamate-evoked temporalis muscle pain and vasomotor responses was investigated in healthy men and women over a 60 day time course. Subjects participated in a pre-BoNTA session where their responses to injection of glutamate (1 M, 0.2 mL) and saline (0.2 mL) into the temporalis muscles were assessed. On Day 1, BoNTA (5 U) was injected into one temporalis muscle and saline into the contralateral temporalis muscle, in a randomized order. Subjects then received intramuscular injections of glutamate (1 M, 0.2 mL) into the left and right temporalis muscles at 3 h and subsequently 7, 30 and 60 days post-injection of BoNTA. Pain intensity, pain area, and neurogenic inflammation (skin temperature and skin blood perfusion) were recorded. Prior to BoNTA treatment, glutamate evoked significantly greater pain and vasomotor reactions (P < 0.001) than saline. BoNTA significantly reduced glutamate-evoked pain intensity (P < 0.05), pain area (P < 0.01), skin blood perfusion (P < 0.05), and skin temperature (P < 0.001). The inhibitory effect of BoNTA was present at 3 h after injection, peaked after 7 days and returned to baseline by 60 days. Findings from the present study demonstrated a rapid action of BoNTA on glutamate-evoked pain and neurogenic inflammation, which is in line with animal studies. PMID:24517906

  3. Time-lapse ERT interpretation methodology for leachate injection monitoring based on multiple inversions and a clustering strategy (MICS)

    NASA Astrophysics Data System (ADS)

    Audebert, M.; Clément, R.; Touze-Foltz, N.; Günther, T.; Moreau, S.; Duquennoi, C.

    2014-12-01

    Leachate recirculation is a key process in municipal waste landfills functioning as bioreactors. To quantify the water content and to assess the leachate injection system, in-situ methods are required to obtain spatially distributed information, usually electrical resistivity tomography (ERT). This geophysical method is based on the inversion process, which presents two major problems in terms of delimiting the infiltration area. First, it is difficult for ERT users to choose an appropriate inversion parameter set. Indeed, it might not be sufficient to interpret only the optimum model (i.e. the model with the chosen regularisation strength) because it is not necessarily the model which best represents the physical process studied. Second, it is difficult to delineate the infiltration front based on resistivity models because of the smoothness of the inversion results. This paper proposes a new methodology called MICS (multiple inversions and clustering strategy), which allows ERT users to improve the delimitation of the infiltration area in leachate injection monitoring. The MICS methodology is based on (i) a multiple inversion step by varying the inversion parameter values to take a wide range of resistivity models into account and (ii) a clustering strategy to improve the delineation of the infiltration front. In this paper, MICS was assessed on two types of data. First, a numerical assessment allows us to optimise and test MICS for different infiltration area sizes, contrasts and shapes. Second, MICS was applied to a field data set gathered during leachate recirculation on a bioreactor.

  4. One-time injection of AAV8 encoding urocortin 2 provides long-term resolution of insulin resistance

    PubMed Central

    Gao, Mei Hua; Giamouridis, Dimosthenis; Lai, N. Chin; Walenta, Evelyn; Paschoal, Vivian Almeida; Kim, Young Chul; Miyanohara, Atsushi; Guo, Tracy; Liao, Min; Liu, Li; Ciaraldi, Theodore P.; Bhargava, Aditi; Oh, Da Young; Hammond, H. Kirk

    2016-01-01

    Using mice rendered insulin resistant with high fat diets (HFD), we examined blood glucose levels and insulin resistance after i.v. delivery of an adeno-associated virus type 8 encoding murine urocortin 2 (AAV8.UCn2). A single i.v. injection of AAV8.UCn2-normalized blood glucose and glucose disposal within weeks, an effect that lasted for months. Hyperinsulinemic-euglycemic clamps showed reduced plasma insulin, increased glucose disposal rates, and increased insulin sensitivity following UCn2 gene transfer. Mice with corticotropin-releasing hormone type 2-receptor deletion that were rendered insulin resistant by HFD showed no improvement in glucose disposal after UCn2 gene transfer, indicating that the effect requires UCn2’s cognate receptor. We also demonstrated increased glucose disposal after UCn2 gene transfer in db/db mice, a second model of insulin resistance. UCn2 gene transfer reduced fatty infiltration of the liver in both models of insulin resistance. UCn2 increases Glut4 translocation to the plasma membrane in skeletal myotubes in a manner quantitatively similar to insulin, indicating a mechanism through which UCn2 operates to increase insulin sensitivity. UCn2 gene transfer, in a dose-dependent manner, is insulin sensitizing and effective for months after a single injection. These findings suggest a potential long-term therapy for clinical type-2 diabetes. PMID:27699250

  5. Development of a programmable piggyback syringe pump and four-times-a-day injection regimen for superovulation in non-lactating Holstein cows

    PubMed Central

    IRSHAD, Abdul Razaq; SASAKI, Taihei; KUBO, Tomoaki; ODASHIMA, Naoyuki; KATANO, Keiji; OSAWA, Takeshi; TAKAHASHI, Toru; IZAIKE, Yoshiaki

    2015-01-01

    The objectives of the present study were to develop a programmable piggyback syringe pump for bovine superovulation and to evaluate the effects of a four-times-a-day injection regimen using the pump. Non-lactating Holstein cows were treated with a total of 30 armour units of porcine FSH by injection four times a day with the pump (study, n = 9) or injection twice a day manually (control, n = 9) for four consecutive days from D10 of the estrous cycle. The pump-driven program successfully induced superovulation in all cows tested. The numbers of small (3– < 5 mm in diameter) and large (≥ 10 mm in diameter) follicles were greater in the study group on D11-13 and D14, respectively. There were fewer unovulated follicles detected on D21 (7 days after estrus) in the study group than in the control group (1.2 ± 0.4 and 3.2 ± 0.6, respectively). PMID:26052155

  6. Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

    PubMed Central

    Kim, Sung Rae; Ho, Myoung Jin; Lee, Eugene; Lee, Joon Woo; Choi, Young Wook; Kang, Myung Joo

    2015-01-01

    Positively surface-charged poly(lactide-co-glycolide) (PLGA)/Eudragit RL nanoparticles (NPs) were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva®) revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1′-dioctadecyl-3,3,3′,3′ tetramethylindotricarbocyanine iodide, DiR) displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively. PMID:26345227

  7. Influence of Hold Time on Creep-Fatigue Behavior of an Advanced Austenitic Alloy

    SciTech Connect

    Mark Carroll; Laura Carroll

    2011-09-01

    An advanced austenitic alloy, HT-UPS (high temperature-ultrafine precipitate strengthened), is a candidate material for the structural components of fast reactors and energy-conversion systems. HT-UPS provides improved creep resistance through a composition based on 316 stainless steel (SS) with additions of Ti and Nb to form nano-scale MC precipitates in the austenitic matrix. The low cycle fatigue and creep-fatigue behavior of a HT-UPS alloy has been investigated at 650 C, 1.0% total strain, and an R ratio of -1 with hold times as long as 9000 sec at peak tensile strain. The cyclic deformation response of HT-UPS is compared to that of 316 SS. The cycles to failure are similar, despite differences in peak stress profiles and the deformed microstructures. Cracking in both alloys is transgranular (initiation and propagation) in the case of continuous cycle fatigue, while the primary cracks also propagate transgranularly during creep-fatigue cycling. Internal grain boundary damage as a result of the tensile hold is present in the form of fine cracks for hold times of 3600 sec and longer and substantially more internal cracks are visible in 316 SS than HT-UPS. The dislocation substructures observed in the deformed material are different. An equiaxed cellular structure is observed in 316 SS, whereas tangles of dislocations are present at the nanoscale MC precipitates in HT-UPS and no cellular substructure is observed.

  8. Advances in Breeding Management and Use of Ovulation Induction for Fixed-time AI.

    PubMed

    Kirkwood, R N; Kauffold, J

    2015-07-01

    The objective of the breeding herd is the predictable and consistent production of high quality pigs. To achieve this objective, an appropriate number of females need to be mated in each breeding week and they should maintain their pregnancy and deliver large litters. Many factors can impact achievement of optimal sow productivity, particularly breeding management. Most matings will involve artificial insemination (AI), and successful AI requires deposition into the cervix (or beyond) of sufficient viable high quality sperm at an appropriate time relative to ovulation. This is facilitated by improved knowledge of the sow's ovarian function prior to and during her oestrous period. Realization of the importance of establishing an adequate sperm reservoir in the oviduct at an appropriate time relative to ovulation has led to advances in the management of AI. The future of AI will likely involve insemination of single doses of high genetic merit semen, potentially having a reduced sperm concentration which is made possible by knowledge of the effect of site of sperm deposition on sow fertility. In particular, knowledge of when a sow is likely to ovulate during a natural or induced oestrous period will prove invaluable in the maintenance of herd productivity. This review will examine options for breeding management, including the control of oestrus and ovulation, on sow herd reproductive performance.

  9. Fuel injection apparatus

    SciTech Connect

    Omori, T.; Sakakibara, S.; Kato, M.; Masuda, A.

    1986-06-10

    A fuel injection apparatus is described for supplying fuel from a fuel tank to at least one combustion chamber of an internal combustion engine, comprising: an injector housing defining therein a pressure cylinder bore, an injection cylinder bore and a timing cylinder bore connected in series with the pressure cylinder bore; a pressure plunger, fitted in the pressure cylinder bore and having one end defining, in the pressure cylinder bore, a pressure pump chamber communicating with the injection cylinder bore and the timing cylinder bore; first fuel supply means for supplying fuel from the fuel tank to the pressure pump chamber; pressurizing means for reciprocating the pressure plunger in the pressure cylinder bore in synchronism with the engine operation so as to pressurize fuel in the pressure pump chamber; an injection plunger, having a diameter smaller than the pressure plunger, fitted in the injection cylinder bore and having two ends defining, in the injection cylinder bore, an injection pump chamber and a first communicating chamber communicating with the pressure pump chamber; second fuel supply means for adjusting the quantity of the fuel from the fuel tank in accordance with engine operation conditions so as to supply the adjusted fuel quantity to the injection pump chamber; injection valve means for injecting the fuel into the fuel pump chamber toward a combustion chamber of the engine when the pressure in the pressure pump chamber is applied to the injection plunger through the first communicating chamber, and the fuel pressure in the injection pump chamber reaches a predetermined injection pressure.

  10. Health-related quality of life advantage of long-acting injectable antipsychotic treatment for schizophrenia: a time trade-off study

    PubMed Central

    2012-01-01

    Background This study was undertaken to estimate utility values for alternative treatment intervals for long acting antipsychotic intramuscular injections for the treatment of schizophrenia. Methods Vignettes were developed using the published literature and an iterative consultation process with expert clinicians and patient representative groups. Four vignettes were developed. The first was a vignette of relapsed/untreated schizophrenia. The other three vignettes presented a standardised picture of well-managed schizophrenia with variations in the intervals between injections: once every 2-weeks, 4-weeks and 3-months. A standardised time trade off (TTO) approach was used to obtain utility values for the vignettes. As a societal perspective was sought, a representative sample of individuals from across the community (Sydney, Australia) was recruited. Ninety-eight people completed the TTO interview. The vignettes were presented in random order to prevent possible ordering effects. Results A clear pattern of increasing utility was observed with increasing time between injections. Untreated schizophrenia was rated as very poor health-related quality of life with a mean (median) utility of 0.27 (0.20). The treated health states were rated at much higher utilities and were statistically significantly different (p < 0.001) from each other: (1) 2-weekly: mean (median) utility = 0.61 (0.65); (2) 4-weekly: mean (median) utility = 0.65 (0.70); (3) 3-monthly: mean (median) utility = 0.70 (0.75). Conclusions This study has provided robust data indicating that approximately a 0.05 utility difference exists between treatment options, with the highest utility assigned to 3-monthly injections. PMID:22472127

  11. Finding a Balance: Fifteen Institutional Case Studies on the Relationship between Part-Time Work and Advanced Level Study. Report.

    ERIC Educational Resources Information Center

    Hodgson, Ann, Ed.; Spours, Ken, Ed.

    This document presents and discusses case studies that examined the relationship between part-time employment and advanced level study at 15 schools in Essex, England. "Foreword" (David Jones) provides a brief overview of the project. "Finding a Balance--Fifteen Institutional Case Studies on the Relationship between Part-time Work…

  12. Piezoelectric Injection Systems

    NASA Astrophysics Data System (ADS)

    Mock, R.; Lubitz, K.

    The origin of direct injection can be doubtlessly attributed to Rudolf Diesel who used air assisted injection for fuel atomisation in his first self-ignition engine. Although it became apparent already at that time that direct injection leads to reduced specific fuel consumption compared to other methods of fuel injection, it was not used in passenger cars for the moment because of its disadvantageous noise generation as the requirements with regard to comfort were seen as more important than a reduced specific consumption.

  13. Effects of in ovo injection of organic trace minerals and post-hatch holding time on broiler performance and bone characteristics.

    PubMed

    Oliveira, T F B; Bertechini, A G; Bricka, R M; Hester, P Y; Kim, E J; Gerard, P D; Peebles, E D

    2015-11-01

    Effects of the in ovo injection of organic Mn, Zn, and Cu in association with post-hatch (POH) feed and water restriction on the performance and physical-chemical bone parameters of male Ross × Ross 708 broilers were examined. On 17 d of incubation, a total of 1,872 eggs were subjected to in ovo injection using a commercial multi-egg injector. Treatments (TRT) includingd non-injected and diluent-injected controls. The respective Zn, Mn, and Cu levels (mg/mL) added to the diluent of the low (LMD) and high mineral (HMD) TRT groups were 0.181, 0.087, and 0.010, and 0.544, 0.260, and 0.030, respectively. The 4 TRT groups were then sub-divided into 2 POH holding time (HT) groups, with 15 birds randomly allocated to each of 6 replicate pens in each of the 8 groups. The first HT group (0HT) had immediate access to water and feed, and the second HT group (24HT) contained birds that were kept in transport baskets for 24 h before being released. Performance was determined and selected birds were subsequently necropsied and their tibiae extracted for analysis. In comparison to birds from 24HT group, those in the 0HT group had a higher BW gain and feed intake, and a lower FCR through 21 d POH. The percentage of bone ash of the birds belonging to the HMD group was higher than all other TRT on d 1 POH and was higher than the non-injection control group on d 21 POH. On d 1, the LMD and HMD groups had higher tibial Mn concentrations than those of the control groups. On d 7, bones from the HMD group had a higher concentration of Mn than did the non-injected control group, and likewise, on d 21 POH, had a higher concentration of Zn than did the control groups. In conclusion, a 24HT negatively affected the performance of the birds during the first 2 wk POH; however, the LMD and HMD TRT had a positive influence on bone mineralization.

  14. A volumetric flow sensor for automotive injection systems

    NASA Astrophysics Data System (ADS)

    Schmid, U.; Krötz, G.; Schmitt-Landsiedel, D.

    2008-04-01

    For further optimization of the automotive power train of diesel engines, advanced combustion processes require a highly flexible injection system, provided e.g. by the common rail (CR) injection technique. In the past, the feasibility to implement injection nozzle volumetric flow sensors based on the thermo-resistive measurement principle has been demonstrated up to injection pressures of 135 MPa (1350 bar). To evaluate the transient behaviour of the system-integrated flow sensors as well as an injection amount indicator used as a reference method, hydraulic simulations on the system level are performed for a CR injection system. Experimentally determined injection timings were found to be in good agreement with calculated values, especially for the novel sensing element which is directly implemented into the hydraulic system. For the first time pressure oscillations occurring after termination of the injection pulse, predicted theoretically, could be verified directly in the nozzle. In addition, the injected amount of fuel is monitored with the highest resolution ever reported in the literature.

  15. A low-cost RK time advancing strategy for energy-preserving turbulent simulations

    NASA Astrophysics Data System (ADS)

    Capuano, Francesco; Coppola, Gennaro; de Luca, Luigi; Balarac, Guillaume

    2014-11-01

    Energy-conserving numerical methods are widely employed in direct and large eddy simulation of turbulent flows. Semi-discrete conservation of energy is usually obtained by adopting the so-called skew-symmetric splitting of the non-linear term, defined as a suitable average of the divergence and advective forms. Although generally allowing global conservation of kinetic energy by convection, it has the drawback of being roughly twice as expensive as standard divergence or advective forms alone. A novel time-advancement strategy that retains the conservation properties of skew-symmetric-based schemes at a reduced computational cost has been developed in the framework of explicit Runge-Kutta schemes. It is found that optimal energy-conservation can be achieved by properly constructed Runge-Kutta methods in which only divergence and advective forms for the convective term are adopted. The new schemes can be considerably faster than skew-symmetric-based techniques. A general framework for the construction of optimized Runge-Kutta coefficients is developed, which has proven to be able to produce new methods with a specified order of accuracy on both solution and energy. The effectiveness of the method is demonstrated by numerical simulation of homogeneous isotropic turbulence.

  16. Advancement of Solidification Processing Technology Through Real Time X-Ray Transmission Microscopy: Sample Preparation

    NASA Technical Reports Server (NTRS)

    Stefanescu, D. M.; Curreri, P. A.

    1996-01-01

    Two types of samples were prepared for the real time X-ray transmission microscopy (XTM) characterization. In the first series directional solidification experiments were carried out to evaluate the critical velocity of engulfment of zirconia particles in the Al and Al-Ni eutectic matrix under ground (l-g) conditions. The particle distribution in the samples was recorded on video before and after the samples were directionally solidified. In the second series samples of the above two type of composites were prepared for directional solidification runs to be carried out on the Advanced Gradient Heating Facility (AGHF) aboard the space shuttle during the LMS mission in June 1996. X-ray microscopy proved to be an invaluable tool for characterizing the particle distribution in the metal matrix samples. This kind of analysis helped in determining accurately the critical velocity of engulfment of ceramic particles by the melt interface in the opaque metal matrix composites. The quality of the cast samples with respect to porosity and instrumented thermocouple sheath breakage or shift could be easily viewed and thus helped in selecting samples for the space shuttle experiments. Summarizing the merits of this technique it can be stated that this technique enabled the use of cast metal matrix composite samples since the particle location was known prior to the experiment.

  17. Advanced mobile multimedia applications: using MPEG-21 and time-dependent metadata.

    NASA Astrophysics Data System (ADS)

    De Sutter, Robbie; Lerouge, Sam; De Neve, Wesley; Lambert, Peter; Van de Walle, Rik

    2003-11-01

    While the price of mobile devices is dropping quickly, the set of features and capabilities of these devices is advancing very dramatically. Because of this, new mobile multimedia applications are conceivable, also thanks to the availability of high speed mobile networks like UMTS and Wireless LAN. However, creating such applications is still difficult due to the huge diversity of features and capabilities of mobile devices. Software developers also have to take into account the rigorous limitation on processing capabilities, display possibilities, and the limited battery life of these devices. On top of that, the availability of the device resources fluctuates strongly during execution of an application, directly and violently influencing the user experience, whereas equivalent fluctuations on traditional desktop PC's are far less prominent. Using new technology like MPEG-4, -7 and -21 can help application developers to overcome these problems. We have created an MPEG-21-based Video-on-Demand application optimized for mobile devices that is aware of the usage environment (i.e., user preference, device capabilities, device conditions, network status, etc.) of the client and adapts the MPEG-4 videos to it. The application is compliant with the Universal Multimedia Access framework, supports Time-Dependent Metadata, and relies on both MPEG-4 and MPEG-21 technology.

  18. Full-Time Instructional Staffing and Outcomes of Advanced Adult Learners

    ERIC Educational Resources Information Center

    Patterson, Margaret Becker

    2016-01-01

    Two core adult education outcomes for advanced adult learners in U.S. states under the National Reporting System are learning gains in adult secondary education and entry into postsecondary education (PSE). Advanced learner outcomes are associated with key functions in an adult education programming framework, as well as with adequate…

  19. Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone.

    PubMed

    Paucard, Alexia; Besson, Valérie C; Plotkine, Michel; Margaill, Isabelle

    2005-02-01

    The aim of this study was to characterize the model of oxidative stress consisting in the infection of malonate (3 mumol), an inhibitor of mitochondrial complex II, in the rat striatum. The striatal concentrations of both the reduced and oxidized forms of glutathione (the major endogenous antioxidant) were determined at various times after malonate injection (1-4 h) in order to evaluate the evolution of oxidative stress. The progression of lesion size and edema was also determined up to 24 h after malonate administration. Finally, the effect of alpha-phenyl-N-tert-butylnitrone (PBN), an antioxidant nitrone, was studied. The levels of reduced glutathione (GSH) progressively decreased after malonate injection up to 40% of those of sham animals at 4 h. An increase in the concentrations of oxidized glutathione (GSSG) was also observed as early as 1 h after malonate administration which was maintained up to 4 h. The size of the lesion was maximal within 2 h of malonate injection, whereas edema continued to increase between 2 and 24 h. Injection of PBN at 100 mg/kg i.p. 30 min before and 2 h after malonate administration abolished the GSSG increase caused by malonate but did not modify the drop in GSH. This moderate antioxidant effect of PBN was associated with a slight decrease of the lesion area at two levels (10.7 and 10.2 mm anterior to the interaural line), but the lesion volume remained unchanged. By contrast, PBN reduced edema by 30%. Taken together, these results show that malonate induced a severe oxidative stress leading to the rapid development of the lesion. PBN demonstrates anti-edematous properties that are not sufficient to reduce the lesion.

  20. Increased atherosclerosis and glomerulonephritis in cynomolgus monkeys (Macaca fascicularis) given injections of BSA over an extended period of time.

    PubMed Central

    Stills, H. F.; Bullock, B. C.; Clarkson, T. B.

    1983-01-01

    A study was conducted to compare the effects of experimental immune complex disease on the development of glomerulonephritis and aortic and coronary artery atherosclerosis. Fourteen adult male macaques (Macaca fascicularis) were fed a mildly atherogenic diet. Ten of these animals were given repeated intravenous injections of bovine serum albumin (BSA), and the remaining 4 were given similar injections of saline. Three of the monkeys given BSA responded with a high antibody titer, 4 with a moderate titer, and 3 with a low level titer to BSA. In all 4 monkeys with the moderate antibody response glomerulonephritis developed, characterized by increased glomerular cellularity, electron-dense deposits in the glomerular capillary basal lamina, and deposits of IgG, IgM, C3, C4, and BSA. Glomerulonephritis was not seen in the other 6 monkeys given BSA or the 4 control monkeys. Aortic lesions seen at necropsy consisted of a few fatty intimal streaks with no differences between test monkeys (given BSA) and control monkeys (given saline). There was no correlation between total serum cholesterol concentration, high-density lipoprotein cholesterol concentration, or BSA antibody levels and the degree of aortic atherosclerosis. Immunochemical stains for immunoglobulins and complement components revealed increased intimal staining when intimal thickness increased. Medial staining for immunoglobulin and complement components appeared to be slightly increased in monkeys with moderately high-level titers of BSA. The extent of atherosclerosis in the coronary arteries of monkeys given BSA was greater than in the control animals. Differences in the extent and severity of the atherosclerotic lesions were most pronounced in the proximal portions of the main coronary arteries, suggesting an increased susceptibility of this site to immune-complex-exacerbated atherosclerosis. In addition to the increased lesion severity in monkeys given BSA, there were numerous granulocytes seen within

  1. Interaction of Porosity with an Advancing Solid/Liquid Interface: a Real-Time Investigation

    NASA Technical Reports Server (NTRS)

    Sen, S.; Kaukler, W.; Catalina, A.; Stefanescu, D.; Curreri, P.

    1999-01-01

    Problems associated with formation of porosity during solidification continue to have a daily impact on the metal forming industry. Several past investigations have dealt with the nucleation and growth aspects of porosity. However, investigations related to the interaction of porosity with that of a solidification front has been limited mostly to organic analogues. In this paper we report on real time experimental observations of such interactions in metal alloys. Using a state of the art X-Ray Transmission Microscope (XTM) we have been able to observe and record the dynamics of the interaction. This includes distortion of the solid/liquid interface near a poro.sity, solute segr,egation patterns surrounding a porosity and the change in shape of the porosity during interaction with an advancing solid/liquid interface. Results will be presented for different Al alloys and growth conditions. The experimental data will be compared to theory using a recently developed 2D numerical model. The model employs a finite difference approach where the solid/liquid interface is defined through the points at which the interface intersects the grid lines. The transport variables are calculated at these points and the motion of the solidification front is determined by the magnitude of the transport variables. The model accounts for the interplay of the thermal and solutal field and the influence of capilarity to predict the shape of the solid/liquid interface with time in the vicinity of porosity. One can further calculate the perturbation of the solutal field by the presence of porosity in the melt.

  2. Time-domain measurement of terahertz frequency magnetoplasmon resonances in a two-dimensional electron system by the direct injection of picosecond pulsed currents

    NASA Astrophysics Data System (ADS)

    Wu, Jingbo; Sydoruk, Oleksiy; Mayorov, Alexander S.; Wood, Christopher D.; Mistry, Divyang; Li, Lianhe; Linfield, Edmund H.; Giles Davies, A.; Cunningham, John E.

    2016-02-01

    We have investigated terahertz (THz) frequency magnetoplasmon resonances in a two-dimensional electron system through the direct injection of picosecond duration current pulses. The evolution of the time-domain signals was measured as a function of magnetic field, and the results were found to be in agreement with calculations using a mode-matching approach for four modes observed in the frequency range above 0.1 THz. This introduces a generic technique suitable for sampling ultrafast carrier dynamics in low-dimensional semiconductor nanostructures at THz frequencies.

  3. A comparative study of peripheral to central circulation delivery times between intraosseous and intravenous injection using a radionuclide technique in normovolemic and hypovolemic canines

    SciTech Connect

    Cameron, J.L.; Fontanarosa, P.B.; Passalaqua, A.M.

    1989-03-01

    Intraosseous infusion is considered a useful technique for administration of medications and fluids in emergency situations when peripheral intravascular access is unobtainable. This study examined the effectiveness of intraosseous infusion for delivery of substances to the central circulation. Central deliveries of a radionuclide tracer administered by the intraosseous and intravenous routes were evaluated during normovolemic and hypovolemic states. Intraosseous infusion achieved peripheral to central circulation transit times comparable to those achieved by the intravenous route. Analysis of variance revealed no statistically significant differences between the peripheral to central delivery times comparing intraosseous and intravenous administration. The results demonstrate that intraosseous infusion is a rapid and effective method of delivery to the central circulation and is an alternative method for intravascular access. This study also suggests that a radionuclide tracer is useful for the evaluation of transit times following intraosseous injection.

  4. Flow injection mass spectral fingerprints demonstrate chemical differences in Rio Red grapefruit with respect to year, harvest time, and conventional versus organic farming.

    PubMed

    Chen, Pei; Harnly, James M; Lester, Gene E

    2010-04-28

    Spectral fingerprints were acquired for Rio Red grapefruit using flow injection electrospray ionization with ion trap and time-of-flight mass spectrometry (FI-ESI-IT-MS and FI-ESI-TOF-MS). Rio Red grapefruits were harvested 3 times a year (early, mid, and late harvests) in 2005 and 2006 from conventionally and organically grown trees. Data analysis using analysis of variance principal component analysis (ANOVA-PCA) demonstrated that, for both MS systems, the chemical patterns were different as a function of farming mode (conventional vs organic), as well as growing year and time of harvest. This was visually obvious with PCA and was shown to be statistically significant using ANOVA. The spectral fingerprints provided a more inclusive view of the chemical composition of the grapefruit and extended previous conclusions regarding the chemical differences between conventionally and organically grown Rio Red grapefruit.

  5. Simplified Two-Time Step Method for Calculating Combustion and Emission Rates of Jet-A and Methane Fuel With and Without Water Injection

    NASA Technical Reports Server (NTRS)

    Molnar, Melissa; Marek, C. John

    2005-01-01

    A simplified kinetic scheme for Jet-A, and methane fuels with water injection was developed to be used in numerical combustion codes, such as the National Combustor Code (NCC) or even simple FORTRAN codes. The two time step method is either an initial time averaged value (step one) or an instantaneous value (step two). The switch is based on the water concentration in moles/cc of 1x10(exp -20). The results presented here results in a correlation that gives the chemical kinetic time as two separate functions. This two time step method is used as opposed to a one step time averaged method previously developed to determine the chemical kinetic time with increased accuracy. The first time averaged step is used at the initial times for smaller water concentrations. This gives the average chemical kinetic time as a function of initial overall fuel air ratio, initial water to fuel mass ratio, temperature, and pressure. The second instantaneous step, to be used with higher water concentrations, gives the chemical kinetic time as a function of instantaneous fuel and water mole concentration, pressure and temperature (T4). The simple correlations would then be compared to the turbulent mixing times to determine the limiting rates of the reaction. The NASA Glenn GLSENS kinetics code calculates the reaction rates and rate constants for each species in a kinetic scheme for finite kinetic rates. These reaction rates are used to calculate the necessary chemical kinetic times. Chemical kinetic time equations for fuel, carbon monoxide and NOx are obtained for Jet-A fuel and methane with and without water injection to water mass loadings of 2/1 water to fuel. A similar correlation was also developed using data from NASA's Chemical Equilibrium Applications (CEA) code to determine the equilibrium concentrations of carbon monoxide and nitrogen oxide as functions of overall equivalence ratio, water to fuel mass ratio, pressure and temperature (T3). The temperature of the gas entering

  6. Advanced Fire Information System - A real time fire information system for Africa

    NASA Astrophysics Data System (ADS)

    Frost, P. E.; Roy, D. P.

    2012-12-01

    The Council for Scientific and Industrial Research (CSIR) lead by the Meraka Institute and supported by the South African National Space Agency (SANSA) developed the Advanced Fire Information System (AFIS) to provide near real time fire information to a variety of operational and science fire users including disaster managers, fire fighters, farmers and forest managers located across Southern and Eastern Africa. The AFIS combines satellite data with ground based observations and statistics and distributes the information via mobile phone technology. The system was launched in 2004, and Eskom (South Africa' and Africa's largest power utility) quickly became the biggest user and today more than 300 Eskom line managers and support staff receive cell phone and email fire alert messages whenever a wildfire is within 2km of any of the 28 000km of Eskom electricity transmission lines. The AFIS uses Earth observation satellites from NASA and Europe to detect possible actively burning fires and their fire radiative power (FRP). The polar orbiting MODIS Terra and Aqua satellites provide data at around 10am, 15pm, 22am and 3am daily, while the European Geostationary MSG satellite provides 15 minute updates at lower spatial resolution. The AFIS processing system ingests the raw satellite data and within minutes of the satellite overpass generates fire location and FRP based fire intensity information. The AFIS and new functionality are presented including an incident report and permiting system that can be used to differentiate between prescribed burns and uncontrolled wild fires, and the provision of other information including 5-day fire danger forecasts, vegetation curing information and historical burned area maps. A new AFIS mobile application for IOS and Android devices as well as a fire reporting tool are showcased that enable both the dissemination and alerting of fire information and enable user upload of geo tagged photographs and on the fly creation of fire reports

  7. High-throughput real-time x-ray microtomography at the Advanced Photon Source

    NASA Astrophysics Data System (ADS)

    De Carlo, Francesco; Albee, Paul B.; Chu, Yong S.; Mancini, Derrick C.; Tieman, Brian; Wang, Steve Y.

    2002-01-01

    It is now possible for large volumes of synchrotron- radiation-generated micro-tomography data to be produced at gigabyte-per-minute rates, especially when using currently available CCD cameras at a high-brightness source, such as the Advanced Photon Source (APS). Recent improvements in the speed of our detectors and stages, combined with increased photon flux supplied by a newly installed double multilayer monochromator, allow us to achieve these data rates on a bending magnet beamline. Previously, most x-ray microtomography experiments have produced data at comparatively lower rates, and often the data were analyzed after the experiment. The time needed to generate complete data sets meant putting off analysis to the completion of a run, thus preventing the user from evaluating the usefulness of a data set and consequently impairing decision making during data acquisition as to how to proceed. Thus, the ability to provide to a tomography user a fully reconstructed data set in few minutes is one of the major problems to be solved when dealing with high-throughput x- ray tomography. This is due to the complexity of the data analysis that involves data preprocessing, sinogram generation, 3D reconstruction, and rendering. At the APS, we have developed systems and techniques to address this issue. We present a method that uses a cluster-based, parallel- computing system based on the Message Passing Interface (MPI) standard. Among the advantages of this approach are the portability, ease-of-use, and low cost of the system. The combination of high-speed, online analysis with high- throughput acquisition allows us to acquire and reconstruct a 512x512x512-voxel sample with a few microns resolution in less than ten minutes.

  8. Musculoskeletal Injection

    PubMed Central

    Wittich, Christopher M.; Ficalora, Robert D.; Mason, Thomas G.; Beckman, Thomas J.

    2009-01-01

    Patients commonly present to primary care physicians with musculoskeletal symptoms. Clinicians certified in internal medicine must be knowledgeable about the diagnosis and management of musculoskeletal diseases, yet they often receive inadequate postgraduate training on this topic. The musculoskeletal problems most frequently encountered in our busy injection practice involve, in decreasing order, the knees, trochanteric bursae, and glenohumeral joints. This article reviews the clinical presentations of these problems. It also discusses musculoskeletal injections for these problems in terms of medications, indications, injection technique, and supporting evidence from the literature. Experience with joint injection and the pharmacological principles described in this article should allow primary care physicians to become comfortable and proficient with musculoskeletal injections. PMID:19720781

  9. New Reduced Two-Time Step Method for Calculating Combustion and Emission Rates of Jet-A and Methane Fuel With and Without Water Injection

    NASA Technical Reports Server (NTRS)

    Molnar, Melissa; Marek, C. John

    2004-01-01

    A simplified kinetic scheme for Jet-A, and methane fuels with water injection was developed to be used in numerical combustion codes, such as the National Combustor Code (NCC) or even simple FORTRAN codes that are being developed at Glenn. The two time step method is either an initial time averaged value (step one) or an instantaneous value (step two). The switch is based on the water concentration in moles/cc of 1x10(exp -20). The results presented here results in a correlation that gives the chemical kinetic time as two separate functions. This two step method is used as opposed to a one step time averaged method previously developed to determine the chemical kinetic time with increased accuracy. The first time averaged step is used at the initial times for smaller water concentrations. This gives the average chemical kinetic time as a function of initial overall fuel air ratio, initial water to fuel mass ratio, temperature, and pressure. The second instantaneous step, to be used with higher water concentrations, gives the chemical kinetic time as a function of instantaneous fuel and water mole concentration, pressure and temperature (T4). The simple correlations would then be compared to the turbulent mixing times to determine the limiting properties of the reaction. The NASA Glenn GLSENS kinetics code calculates the reaction rates and rate constants for each species in a kinetic scheme for finite kinetic rates. These reaction rates were then used to calculate the necessary chemical kinetic times. Chemical kinetic time equations for fuel, carbon monoxide and NOx were obtained for Jet-A fuel and methane with and without water injection to water mass loadings of 2/1 water to fuel. A similar correlation was also developed using data from NASA's Chemical Equilibrium Applications (CEA) code to determine the equilibrium concentrations of carbon monoxide and nitrogen oxide as functions of overall equivalence ratio, water to fuel mass ratio, pressure and temperature (T3

  10. Fuel injection system

    SciTech Connect

    Herth, H.; Kraus, B.; Sautter, W.; Wessel, W.

    1983-03-15

    A fuel injection system for an internal combustion engine includes electromagnetic injection valves controlled by a fuel control unit which receives signals from a camshaft actuated switch, a position-dependent throttle transducer and an oxygen sensor. When the oxygen sensor changes output levels, the transmission of this information is delayed, by the action of a switching transistor controlled by a monostable multivibrator, for a period of time equal to the internal time constant of the multivibrator.

  11. Characterization of metabolites in rats after intravenous administration of salvianolic acid for injection by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.

    PubMed

    Miao, Jingzhuo; Sun, Wanyang; Huang, Jingyi; Liu, Xiaolin; Li, Shuming; Han, Xiaoping; Tong, Ling; Sun, Guoxiang

    2016-09-01

    It is an essential requirement to clarify the metabolites of traditional Chinese medicine (TCM) injections, which contain numerous ingredients, to assess their safe and effective use in clinic. Salvianolic acid for injection (SAFI), made from hydrophilic phenolic acids in Salvia miltiorrhiza Bunge, has been widely used for the treatment of cerebrovascular diseases, but information on its metabolites in vivo is still lacking. In the present study, we aimed to holistically characterize the metabolites of the main active ingredients in rat plasma, bile, urine and feces following intravenous administration of SAFI. An ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) method was developed. Combining information on retention behaviors, multistage mass spectra and literature data, a total of eight prototypes and 52 metabolites were tentatively characterized. Metabolites originated from rosmarinic acid and salvianolic acid B comprised the majority of identified compounds. Meanwhile, four metabolites derived from salvianolic acid D and five from salvianolic acid B are reported for the first time. This study revealed that methylation, sulfation and glucuronidation were the major metabolic pathways of phenolic acids in SAFI in vivo. Furthermore, the developed UPLC/Q-TOF-MS method could also benefit the metabolic investigation of extracts and preparations in TCM with hydrophilic ingredients. Copyright © 2016 John Wiley & Sons, Ltd.

  12. Research and development program for the development of advanced time-temperature dependent constitutive relationships. Volume 2: Programming manual

    NASA Technical Reports Server (NTRS)

    Cassenti, B. N.

    1983-01-01

    The results of a 10-month research and development program for nonlinear structural modeling with advanced time-temperature constitutive relationships are presented. The implementation of the theory in the MARC nonlinear finite element code is discussed, and instructions for the computational application of the theory are provided.

  13. Response Times of Children and Adolescents with Asperger Syndrome on an "Advanced" Test of Theory of Mind

    ERIC Educational Resources Information Center

    Kaland, Nils; Smith, Lars; Mortensen, Erik Lykke

    2007-01-01

    In the present study the response times of 10- to 20-year-old participants with Asperger syndrome (AS) (N = 21) of normal intelligence and a control group of typically developing individuals (N = 20) were recorded on a new "advanced" test of theory of mind. This test taps the ability to make mental-state inferences versus physical-state inferences…

  14. Time-lapse 3D VSP monitoring of a carbon dioxide injection project at Delhi Field, Louisiana

    NASA Astrophysics Data System (ADS)

    Lubis, Muhammad Husni Mubarak

    Delhi Field is a producing oil field located in northeastern Louisiana. The estimated original oil in place (OOIP) is 357 mmbo and approximately 54% of OOIP has been produced through the primary production and water-flooding. A CO2-EOR program has been implemented since November 2009 to recover an additional 17% of OOIP. Reservoir surveillance using time-lapse 3D seismic data has been conducted to monitor the CO2 sweep efficiency. The goal of this study is to monitor the CO2 flow-path in the area around the injector using time-lapse 3D VSP data. For this purpose, two 3D VSPs acquired in June 2010 and again in August 2011 were processed together. Fluid substitution and VSP modeling were performed to understand the influence of pore-fluid saturation change on VSP records. A cross-equalization was performed to improve the similarity of the datasets. This step is important to reduce the ambiguity in time-lapse observation. The splice of a 3D VSP image into the surface seismic data becomes the key point in determining the reflector of the reservoir. By integrating the observation from the modeling and the splice of 3D VSP image to surface seismic, the CO2 flow-path from injector 164-3 can be identified from 3D time-lapse VSP data. The CO2 was not radially distributed around the injector, but moved toward southwest direction. This finding is also consistent with the flow-path interpreted from surface seismic. This consistency implies that time-lapse 3D VSP surveys at Delhi Field confirm and augment the time-lapse interpretation from surface seismic data.

  15. Fuel injection pump device and method for settling the same

    SciTech Connect

    Ishida, A.; Itoh, K.; Oikawa, H.; Vehara, K.

    1988-07-05

    This patent describes a fuel injection pump device which comprises: a delivery valve communicated with a pressurizing chamber formed in a housing, loaded by a spring and communicated with a fuel injection nozzle; a plunger with its one end facing the pressurizing chamber and the other end operatively connected with a cam which is driven by an engine; a fuel chamber provided so as to surround the plunger in the housing; an oil passage formed in the plunger so that its one end communicates to the pressurizing chamber and the other end communicates to the fuel chamber; a control sleeve slidably mounted on the outer periphery of the plunger in the fuel chamber; a control groove provided on the outer peripheral surface of the plunger for communicating the pressurizing chamber and fuel chamber to each other by way of the oil passages or for interrupting the same. The control groove has at least longitudinally directed edges and inclined edges provided with relation to the axis of the plunger; control ports provided on the control sleeve and communicating the control groove to the fuel chamber when a fuel injection is completed; an injection quantity control member supported on the housing for controlling a fuel injection quantity; an injection timing control member for moving the control sleeve in the axial direction of the plunger; fuel injection control means for controlling the injection quantity control member and the injection timing control member in accordance with signals from operating state information sources, the fuel injection means is composed so as to advance the injection timing control member on the basis of the information of the engine in a high speed region from the operating state information sources.

  16. A computer program for estimating the power-density spectrum of advanced continuous simulation language generated time histories

    NASA Technical Reports Server (NTRS)

    Dunn, H. J.

    1981-01-01

    A computer program for performing frequency analysis of time history data is presented. The program uses circular convolution and the fast Fourier transform to calculate power density spectrum (PDS) of time history data. The program interfaces with the advanced continuous simulation language (ACSL) so that a frequency analysis may be performed on ACSL generated simulation variables. An example of the calculation of the PDS of a Van de Pol oscillator is presented.

  17. Session 20: Injection Overview

    SciTech Connect

    Prestwich, Susan

    1983-12-01

    The test program was initiated at the Raft River Geothermal Field in southern Idaho in September 1982. A series of eight short-term injection and backflow tests, followed by a long-term injection test, were conducted on one well in the field. Tracers were added during injection and monitored during backflow as well. The principal objective was to determine if tracers could be effectively used as a means to assess reservoir characteristics in a one-well test. The test program resulted in a unique data set which shows promise as a means to improve understanding of the reservoir characteristics. In December 1982, an RFP was issued to obtain an industrial partner to obtain follow-on data on the injection/backflow technique in a second field, and to study any alternate advanced concepts for injection testing which the industrial community might recommend. The East Mesa Geothermal Field was selected for the second test series. Two wells were utilized for testing, and a series of ten tests were conducted in July and August 1983, aimed principally at further evaluation of the injection/backflow technique.

  18. Simulating the Black Saturday 2009 smoke plume with an interactive composition-climate model: Sensitivity to emissions amount, timing, and injection height

    NASA Astrophysics Data System (ADS)

    Field, Robert D.; Luo, Ming; Fromm, Mike; Voulgarakis, Apostolos; Mangeon, Stéphane; Worden, John

    2016-04-01

    We simulated the high-altitude smoke plume from the early February 2009 Black Saturday bushfires in southeastern Australia using the NASA Goddard Institute for Space Studies ModelE2. To the best of our knowledge, this is the first single-plume analysis of biomass burning emissions injected directly into the upper troposphere/lower stratosphere (UTLS) using a full-complexity composition-climate model. We compared simulated carbon monoxide (CO) to a new Aura Tropospheric Emission Spectrometer/Microwave Limb Sounder joint CO retrieval, focusing on the plume's initial transport eastward, anticyclonic circulation to the north of New Zealand, westward transport in the lower stratospheric easterlies, and arrival over Africa at the end of February. Our goal was to determine the sensitivity of the simulated plume to prescribed injection height, emissions amount, and emissions timing from different sources for a full-complexity model when compared to Aura. The most realistic plumes were obtained using injection heights in the UTLS, including one drawn from ground-based radar data. A 6 h emissions pulse or emissions tied to independent estimates of hourly fire behavior produced a more realistic plume in the lower stratosphere compared to the same emissions amount being released evenly over 12 or 24 h. Simulated CO in the plume was highly sensitive to the differences between emissions amounts estimated from the Global Fire Emissions Database and from detailed, ground-based estimates of fire growth. The emissions amount determined not only the CO concentration of the plume but also the proportion of the plume that entered the stratosphere. We speculate that this is due to either or both nonlinear CO loss with a weakened OH sink or plume self-lofting driven by shortwave absorption of the coemitted aerosols.

  19. Certolizumab Injection

    MedlinePlus

    ... has not improved when treated with other medications, rheumatoid arthritis (a condition in which the body attacks its ... continues. When certolizumab injection is used to treat rheumatoid arthritis, it is usually given every other week and ...

  20. Natalizumab Injection

    MedlinePlus

    ... prevent episodes of symptoms in people who have Crohn's disease (a condition in which the body attacks the ... If you are receiving natalizumab injection to treat Crohn's disease, your symptoms should improve during the first few ...

  1. Vedolizumab Injection

    MedlinePlus

    ... injection may cause serious allergic reactions during an infusion and for several hours afterward. A doctor or ... of the following symptoms during or after your infusion: rash; itching; swelling of the face, eyes, mouth, ...

  2. Panitumumab Injection

    MedlinePlus

    ... as a solution (liquid) to be given by infusion (injected into a vein). It is usually given ... doctor or nurse in a doctor's office or infusion center. Panitumumab is usually given once every 2 ...

  3. Methotrexate Injection

    MedlinePlus

    ... woman's uterus while she is pregnant), breast cancer, lung cancer, certain cancers of the head and neck; certain ... Methotrexate injection is also used along with rest, physical therapy and ... treat rheumatoid arthritis by decreasing the activity of the immune system.

  4. Alirocumab Injection

    MedlinePlus

    ... injection is used along with diet and certain cholesterol-lowering medications (HMG-CoA reductase inhibitors [statins]) in ... familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally) or ...

  5. Evolocumab Injection

    MedlinePlus

    ... injection is used along with diet and certain cholesterol-lowering medications, HMG-CoA reductase inhibitors (statins), in ... heterozygous hypercholesterolemia (HeFH; an inherited condition in which cholesterol cannot be removed from the body normally) or ...

  6. Pentamidine Injection

    MedlinePlus

    Pentamidine injection is used to treat pneumonia caused by a fungus called Pneumocystis carinii. It is in a class of medications called antiprotozoals. It works by stopping the growth of protozoa that can cause pneumonia.

  7. Oxytocin Injection

    MedlinePlus

    Oxytocin injection is used to begin or improve contractions during labor. Oxytocin also is used to reduce bleeding after childbirth. ... other medications or procedures to end a pregnancy. Oxytocin is in a class of medications called oxytocic ...

  8. Ibritumomab Injection

    MedlinePlus

    ... is in a class of medications called monoclonal antibodies with radioisotopes. It works by attaching to cancer ... you receive ibritumomab injection, your body may develop antibodies (substances in the blood that help the immune ...

  9. Ganciclovir Injection

    MedlinePlus

    ... problems, eye problems other than CMV retinitis, or kidney disease.tell your doctor if you are pregnant or plan to become pregnant. Ganciclovir injection may cause infertility (difficulty becoming pregnant). However, if you are a ...

  10. Bendamustine Injection

    MedlinePlus

    ... a type of cancer of the white blood cells). Bendamustine injection is also used to treat a ... that begins in a type of white blood cell that normally fights infection) that is slow spreading, ...

  11. Vancomycin Injection

    MedlinePlus

    ... medications called glycopeptide antibiotics. It works by killing bacteria that cause infections.Antibiotics such as vancomycin injection ... infection may not be completely treated and the bacteria may become resistant to antibiotics.

  12. Levofloxacin Injection

    MedlinePlus

    ... of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections.Antibiotics such as levofloxacin injection ... infection may not be completely treated and the bacteria may become resistant to antibiotics.

  13. Doxycycline Injection

    MedlinePlus

    ... medications called tetracycline antibiotics. It works by killing bacteria that cause infections.Antibiotics such as doxycycline injection ... infection may not be completely treated and the bacteria may become resistant to antibiotics.

  14. Sumatriptan Injection

    MedlinePlus

    ... accompanied by nausea and sensitivity to sound and light). Sumatriptan injection is also used to treat the ... children. Store it at room temperature, away from light, excess heat, and moisture (not in the bathroom). ...

  15. Epinephrine Injection

    MedlinePlus

    Epinephrine injection is used along with emergency medical treatment to treat life-threatening allergic reactions caused by ... or stings, foods, medications, latex, and other causes. Epinephrine is in a class of medications called alpha- ...

  16. Trastuzumab Injection

    MedlinePlus

    ... with other medications to treat certain types of stomach cancer that have spread to other parts of the ... weeks. When trastuzumab injection is used to treat stomach cancer, it is usually given once every 3 weeks. ...

  17. Topotecan Injection

    MedlinePlus

    ... organs where eggs are formed) and small cell lung cancer (a type of cancer that begins in the ... topotecan injection is used to treat ovarian or lung cancer, it is usually given once a day for ...

  18. Palonosetron Injection

    MedlinePlus

    ... that may occur several days after receiving certain chemotherapy medications. Palonosetron injection is in a class of medications called 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a natural ...

  19. Meropenem Injection

    MedlinePlus

    ... skin and abdominal (stomach area) infections caused by bacteria and meningitis (infection of the membranes that surround ... of medications called antibiotics. It works by killing bacteria that cause infection.Antibiotics such as meropenem injection ...

  20. Amikacin Injection

    MedlinePlus

    ... treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that ... medications called aminoglycoside antibiotics. It works by killing bacteria.Antibiotics such as amikacin injection will not work ...

  1. Ertapenem Injection

    MedlinePlus

    ... abdominal (stomach area) infections, that are caused by bacteria. It is also used for the prevention of ... medications called carbapenem antibiotics. It works by killing bacteria.Antibiotics such as ertapenem injection will not work ...

  2. Moxifloxacin Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria such as pneumonia; ; and , skin, and abdominal (stomach ... antibiotics called fluoroquinolones. It works by killing the bacteria that cause infections.Antibiotics such as moxifloxacin injection ...

  3. Cefepime Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria including pneumonia, and skin, urinary tract, and kidney ... medications called cephalosporin antibiotics. It works by killing bacteria.Antibiotics such as cefepime injection will not work ...

  4. Cefazolin Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria including skin, bone, joint, genital, blood, heart valve, ... medications called cephalosporin antibiotics. It works by killing bacteria.Antibiotics such as cefazolin injection will not work ...

  5. Daptomycin Injection

    MedlinePlus

    ... blood infections or serious skin infections caused by bacteria. Daptomycin injection is in a class of medications called cyclic lipopeptide antibiotics. It works by killing bacteria. Antibiotics will not work for treating colds, flu, ...

  6. Aztreonam Injection

    MedlinePlus

    ... to treat certain infections that are caused by bacteria, including respiratory tract (including pneumonia and bronchitis), urinary ... abdominal (stomach area) infections, that are caused by bacteria. Aztreonam injection also may be used before, during, ...

  7. Ceftazidime Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria including pneumonia and other lower respiratory tract (lung) ... medications called cephalosporin antibiotics. It works by killing bacteria.Antibiotics such as ceftazidime injection will not work ...

  8. Tobramycin Injection

    MedlinePlus

    ... treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that ... medications called aminoglycoside antibiotics. It works by killing bacteria.Antibiotics such as tobramycin injection will not work ...

  9. Ciprofloxacin Injection

    MedlinePlus

    ... is used to treat certain infections caused by bacteria such as pneumonia; and infections of the skin, ... of antibiotics called fluoroquinolones. It works by killing bacteria that cause infections.Antibiotics such as ciprofloxacin injection ...

  10. Gentamicin Injection

    MedlinePlus

    ... treat certain serious infections that are caused by bacteria such as meningitis (infection of the membranes that ... medications called aminoglycoside antibiotics. It works by killing bacteria.Antibiotics such as gentamicin injection will not work ...

  11. Ceftaroline Injection

    MedlinePlus

    ... infections and pneumonia (lung infection) caused by certain bacteria. Ceftaroline is in a class of medications called cephalosporin antibiotics. It works by killing bacteria.Antibiotics such as ceftaroline injection will not work ...

  12. Risperidone Injection

    MedlinePlus

    ... release (long-acting) injection is used to treat schizophrenia (a mental illness that causes disturbed or unusual ... do not already have diabetes. If you have schizophrenia, you are more likely to develop diabetes than ...

  13. Omalizumab Injection

    MedlinePlus

    ... steroids. Omalizumab is also used to treat chronic hives without a known cause that cannot successfully be ... is not used to treat other forms of hives or allergic conditions. Omalizumab injection is in a ...

  14. Pegloticase Injection

    MedlinePlus

    ... doctor if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency (an inherited blood disease). Your doctor may test you for G6PD deficiency before you start to receive pegloticase injection. If ...

  15. Lacosamide Injection

    MedlinePlus

    ... with other medications to control certain types of seizures in people who cannot take oral medications. Lacosamide ... If you suddenly stop using lacosamide injection, your seizures may happen more often. Your doctor will probably ...

  16. Oxacillin Injection

    MedlinePlus

    ... injection is in a class of medications called penicillins. It works by killing bacteria.Antibiotics such as ... and pharmacist if you are allergic to oxacillin; penicillins; cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin, cefdinir, ...

  17. Nafcillin Injection

    MedlinePlus

    ... injection is in a class of medications called penicillins. It works by killing bacteria.Antibiotics such as ... and pharmacist if you are allergic to nafcillin; penicillins; cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin, cefdinir, ...

  18. Ampicillin Injection

    MedlinePlus

    ... injection is in a class of medications called penicillins. It works by killing bacteria.Antibiotics such as ... and pharmacist if you are allergic to ampicillin; penicillins; cephalosporin antibiotics such as cefaclor, cefadroxil, cefazolin (Ancef, ...

  19. Naloxone Injection

    MedlinePlus

    ... emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose. ... is also used after surgery to reverse the effects of opiates given during surgery. Naloxone injection is ...

  20. Omacetaxine Injection

    MedlinePlus

    ... or cannot take these medications due to side effects. Omacetaxine injection is in a class of medications ... a treatment cycle if you experience serious side effects of the medication or if blood tests show ...

  1. Methylnaltrexone Injection

    MedlinePlus

    ... injection is used to treat constipation caused by opioid (narcotic) pain medications in patients with chronic (on-going) pain that is not caused by ... by protecting the bowel from the effects of opioid (narcotic) medications.

  2. Denosumab Injection

    MedlinePlus

    ... menstrual periods), who have an increased risk for fractures (broken bones) or who cannot take or did ... receiving certain treatments that increase their risk for fractures. Denosumab injection (Xgeva) is used to reduce fractures ...

  3. Rasburicase Injection

    MedlinePlus

    ... break down) in people with certain types of cancer who are being treated with chemotherapy medications. Rasburicase injection is in a class of medications called enzymes. It works by breaking down uric acid so that the body can eliminate it.

  4. Gemcitabine Injection

    MedlinePlus

    ... with surgery. Gemcitabine is also used to treat cancer of the pancreas that has spread to other parts of the ... 4 weeks. When gemcitabine is used to treat cancer of pancreas it may be injected once every week. The ...

  5. Doxercalciferol Injection

    MedlinePlus

    Doxercalciferol injection is used to treat secondary hyperparathyroidism (a condition in which the body produces too much parathyroid hormone [PTH; a natural substance needed to control the amount of calcium in ...

  6. Granisetron Injection

    MedlinePlus

    ... that may occur after surgery. Granisetron extended-release (long-acting) injection is used with other medications to prevent nausea and vomiting caused by cancer chemotherapy that may occur immediately ...

  7. Fluconazole Injection

    MedlinePlus

    ... injection is used to treat fungal infections, including yeast infections of the mouth, throat, esophagus (tube leading ... by fungus. Fluconazole is also used to prevent yeast infections in patients who are likely to become ...

  8. Docetaxel Injection

    MedlinePlus

    ... allergic to docetaxel injection or drugs made with polysorbate 80, an ingredient found in some medications. Ask ... if a medication you are allergic to contains polysorbate 80. If you experience any of the following ...

  9. Haloperidol Injection

    MedlinePlus

    ... emotions). Haloperidol injection is also used to control motor tics (uncontrollable need to repeat certain body movements) ... people who have Tourette's disorder (condition characterized by motor or verbal tics). Haloperidol is in a class ...

  10. Investigation of injection dose and camera integration time on quantifying pharmacokinetics of a Cy5.5-GX1 probe with dynamic fluorescence imaging in vivo

    NASA Astrophysics Data System (ADS)

    Dai, Yunpeng; Chen, Xueli; Yin, Jipeng; Kang, Xiaoyu; Wang, Guodong; Zhang, Xianghan; Nie, Yongzhan; Wu, Kaichun; Liang, Jimin

    2016-08-01

    The aim of this article is to investigate the influence of a tracer injection dose (ID) and camera integration time (IT) on quantifying pharmacokinetics of Cy5.5-GX1 in gastric cancer BGC-823 cell xenografted mice. Based on three factors, including whether or not to inject free GX1, the ID of Cy5.5-GX1, and the camera IT, 32 mice were randomly divided into eight groups and received 60-min dynamic fluorescence imaging. Gurfinkel exponential model (GEXPM) and Lammertsma simplified reference tissue model (SRTM) combined with a singular value decomposition analysis were used to quantitatively analyze the acquired dynamic fluorescent images. The binding potential (Bp) and the sum of the pharmacokinetic rate constants (SKRC) of Cy5.5-GX1 were determined by the SRTM and EXPM, respectively. In the tumor region, the SKRC value exhibited an obvious trend with change in the tracer ID, but the Bp value was not sensitive to it. Both the Bp and SKRC values were independent of the camera IT. In addition, the ratio of the tumor-to-muscle region was correlated with the camera IT but was independent of the tracer ID. Dynamic fluorescence imaging in conjunction with a kinetic analysis may provide more quantitative information than static fluorescence imaging, especially for a priori information on the optimal ID of targeted probes for individual therapy.

  11. Green technology effect of injection pressure, timing and compression ratio in constant pressure heat addition cycle by an eco-friendly material.

    PubMed

    Karthikayan, S; Sankaranarayanan, G; Karthikeyan, R

    2015-11-01

    Present energy strategies focus on environmental issues, especially environmental pollution prevention and control by eco-friendly green technologies. This includes, increase in the energy supplies, encouraging cleaner and more efficient energy management, addressing air pollution, greenhouse effect, global warming, and climate change. Biofuels provide the panorama of new fiscal opportunities for people in rural area for meeting their need and also the demand of the local market. Biofuels concern protection of the environment and job creation. Renewable energy sources are self-reliance resources, have the potential in energy management with less emissions of air pollutants. Biofuels are expected to reduce dependability on imported crude oil with connected economic susceptibility, reduce greenhouse gases, other pollutants and invigorate the economy by increasing demand and prices for agricultural products. The use of neat paradise tree oil and induction of eco-friendly material Hydrogen through inlet manifold in a constant pressure heat addition cycle engine (diesel engine) with optimized engine operating parameters such as injection timing, injection pressure and compression ratio. The results shows the heat utilization efficiency for neat vegetable oil is 29% and neat oil with 15% Hydrogen as 33%. The exhaust gas temperature (EGT) for 15% of H2 share as 450°C at full load and the heat release of 80J/deg. crank angle for 15% Hydrogen energy share.

  12. The rise of the FGFR inhibitor in advanced biliary cancer: the next cover of time magazine?

    PubMed

    Rizvi, Sumera; Borad, Mitesh J

    2016-10-01

    Cholangiocarcinomas (CCAs) are heterogeneous tumors arising from the biliary tract with features of cholangiocyte differentiation. CCAs are aggressive tumors with limited treatment options and poor overall survival. Only a subset of CCA patients with early stage disease can avail potentially curative treatment options. For advanced biliary tract tumors, currently there are limited effective treatment modalities. Recent advances have provided greater insight into the genomic landscape of CCAs. The fibroblast growth factor receptor (FGFR) pathway is involved in key cellular processes essential to survival and differentiation. Accordingly, aberrant FGFR signaling has significant oncogenic potential. Recent discovery of FGFR2 gene fusions in CCA has heightened interest in FGFR inhibition in advanced biliary tract cancer. These findings have served as a catalyst for ongoing clinical investigation of FGFR inhibition in CCA patients with various FGFR signaling abnormalities. Herein, we review FGFR aberrations in CCA and their prognostic implications, FGFR targeting as a viable therapeutic option in advanced biliary tract malignancies, and future directions for development of combination approaches utilizing FGFR inhibition.

  13. Just-in-Time Teaching: A Tool for Enhancing Student Engagement in Advanced Foreign Language Learning

    ERIC Educational Resources Information Center

    Abreu, Laurel; Knouse, Stephanie

    2014-01-01

    Scholars have indicated a need for further research on effective pedagogical strategies designed for advanced foreign language courses in the postsecondary setting, especially in light of decreased enrollments at this level and the elimination of foreign language programs altogether in some institutions (Paesani & Allen, 2012). This article…

  14. Real-time application of advanced three-dimensional graphic techniques for research aircraft simulation

    NASA Technical Reports Server (NTRS)

    Davis, Steven B.

    1990-01-01

    Visual aids are valuable assets to engineers for design, demonstration, and evaluation. Discussed here are a variety of advanced three-dimensional graphic techniques used to enhance the displays of test aircraft dynamics. The new software's capabilities are examined and possible future uses are considered.

  15. The rise of the FGFR inhibitor in advanced biliary cancer: the next cover of time magazine?

    PubMed Central

    Rizvi, Sumera

    2016-01-01

    Cholangiocarcinomas (CCAs) are heterogeneous tumors arising from the biliary tract with features of cholangiocyte differentiation. CCAs are aggressive tumors with limited treatment options and poor overall survival. Only a subset of CCA patients with early stage disease can avail potentially curative treatment options. For advanced biliary tract tumors, currently there are limited effective treatment modalities. Recent advances have provided greater insight into the genomic landscape of CCAs. The fibroblast growth factor receptor (FGFR) pathway is involved in key cellular processes essential to survival and differentiation. Accordingly, aberrant FGFR signaling has significant oncogenic potential. Recent discovery of FGFR2 gene fusions in CCA has heightened interest in FGFR inhibition in advanced biliary tract cancer. These findings have served as a catalyst for ongoing clinical investigation of FGFR inhibition in CCA patients with various FGFR signaling abnormalities. Herein, we review FGFR aberrations in CCA and their prognostic implications, FGFR targeting as a viable therapeutic option in advanced biliary tract malignancies, and future directions for development of combination approaches utilizing FGFR inhibition. PMID:27747092

  16. Advanced karst hydrological and contaminant monitoring techniques for real-time and high resolution applications

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In telogenetic and soil-mantled karst aquifers, the movement of autogenic recharge through the epikarstic zone and into the regional aquifer can be a complex process and have implications for flooding, groundwater contamination, and other difficult to capture processes. Recent advances in instrument...

  17. Predicting SAT Performance from Advanced Course Content and Timing of Matriculation

    ERIC Educational Resources Information Center

    Patterson, Jonathan Sparks

    2012-01-01

    As record numbers of students are applying to selective colleges and universities, students are attempting to set themselves apart from their peers by taking rigorous advanced courses in high school. The race for improving a student's academic record has resulted in more and more students taking these courses earlier and earlier in their high…

  18. Science and Mathematics Advanced Placement Exams: Growth and Achievement over Time

    ERIC Educational Resources Information Center

    Judson, Eugene

    2017-01-01

    Rapid growth of Advanced Placement (AP) exams in the last 2 decades has been paralleled by national enthusiasm to promote availability and rigor of science, technology, engineering, and mathematics (STEM). Trends were examined in STEM AP to evaluate and compare growth and achievement. Analysis included individual STEM subjects and disaggregation…

  19. Effect of Immerse Temperature and Time on Solvent Debinding Process of Stainless Steel 316L Metal Injection Molding

    NASA Astrophysics Data System (ADS)

    Hafizah Kamarudin, Nur; Irwan Ibrahim, Mohd Halim

    2017-01-01

    This study was carried out to investigate solvent debinding by conducting the extraction process at temperature ranging from 40 to 80 °C within 2 to 8 hours, while keeping the heptane solvent and 12:1 of solvent to feed ratio as constant. The palm kernel loss was evaluated as an indicator of the process’s performance. It was also supported by the pore evolution that was observed by Field Emission Scanning Electron Micrograph (FESEM). Results show that both parameter give large effect on the solvent debinding performance. The best immerse temperature and time for extracting maximum palm kernel in heptane solution at S/F ratio of 12:1, without sacrificing the ability of producing free defect metal part were given by 80 °C and 6 hours, respectively.

  20. Hydraulic fracture monitoring in hard rock at 410 m depth with an advanced fluid-injection protocol and extensive sensor array

    NASA Astrophysics Data System (ADS)

    Zang, A.; Stephansson, O.; Stenberg, L.; Plenkers, K.; Specht, S.; Milkereit, C.; Schill, E.; Kwiatek, G.; Dresen, G.; Zimmermann, G.; Dahm, T.; Weber, M.

    2016-11-01

    In this article, an underground experiment at the Äspö Hard Rock Laboratory (HRL) is described. Main goal is optimizing geothermal heat exchange in crystalline rock mass at depth by multi-stage hydraulic fracturing with minimal impact on the environment, i.e. seismic events. For this, three arrays with acoustic emission, microseismicity and electromagnetic sensors are installed mapping hydraulic fracture initiation and growth. Fractures are driven by three different water injection schemes (continuous, progressive, pulse pressurization). After a brief review of hydraulic fracture operations in crystalline rock mass at mine scale, the site geology and the stress conditions at Äspö HRL are described. Then, the continuous, single-flow rate and alternative, multiple-flow rate fracture breakdown tests in a horizontal borehole at depth level 410 m are described together with the monitoring networks and sensitivity. Monitoring results include the primary catalogue of acoustic emission hypocenters obtained from four hydraulic fractures with the in situ trigger and localizing network. The continuous versus alternative water injection schemes are discussed in terms of the fracture breakdown pressure, the fracture pattern from impression packer result and the monitoring at the arrays. An example of multi-stage hydraulic fracturing with several phases of opening and closing of fracture walls is evaluated using data from acoustic emissions, seismic broadband recordings and electromagnetic signal response. Based on our limited amount of in situ tests (six) and evaluation of three tests in Ävrö granodiorite, in the multiple-flow rate test with progressively increasing target pressure, the acoustic emission activity starts at a later stage in the fracturing process compared to the conventional fracturing case with continuous water injection. In tendency, also the total number and magnitude of acoustic events is found to be smaller in the progressive treatment with frequent

  1. Hydraulic fracture monitoring in hard rock at 410 m depth with an advanced fluid-injection protocol and extensive sensor array

    NASA Astrophysics Data System (ADS)

    Zang, Arno; Stephansson, Ove; Stenberg, Leif; Plenkers, Katrin; Specht, Sebastian; Milkereit, Claus; Schill, Eva; Kwiatek, Grzegorz; Dresen, Georg; Zimmermann, Günter; Dahm, Torsten; Weber, Michael

    2017-02-01

    In this paper, an underground experiment at the Äspö Hard Rock Laboratory (HRL) is described. Main goal is optimizing geothermal heat exchange in crystalline rock mass at depth by multistage hydraulic fracturing with minimal impact on the environment, that is, seismic events. For this, three arrays with acoustic emission, microseismicity and electromagnetic sensors are installed mapping hydraulic fracture initiation and growth. Fractures are driven by three different water injection schemes (continuous, progressive and pulse pressurization). After a brief review of hydraulic fracture operations in crystalline rock mass at mine scale, the site geology and the stress conditions at Äspö HRL are described. Then, the continuous, single-flow rate and alternative, multiple-flow rate fracture breakdown tests in a horizontal borehole at depth level 410 m are described together with the monitoring networks and sensitivity. Monitoring results include the primary catalogue of acoustic emission hypocentres obtained from four hydraulic fractures with the in situ trigger and localizing network. The continuous versus alternative water injection schemes are discussed in terms of the fracture breakdown pressure, the fracture pattern from impression packer result and the monitoring at the arrays. An example of multistage hydraulic fracturing with several phases of opening and closing of fracture walls is evaluated using data from acoustic emissions, seismic broad-band recordings and electromagnetic signal response. Based on our limited amount of in situ tests (six) and evaluation of three tests in Ävrö granodiorite, in the multiple-flow rate test with progressively increasing target pressure, the acoustic emission activity starts at a later stage in the fracturing process compared to the conventional fracturing case with continuous water injection. In tendency, also the total number and magnitude of acoustic events are found to be smaller in the progressive treatment with

  2. About Time: A Metacognitive View of Time and Workload Created by Technological Advancements in an Odl Environment

    ERIC Educational Resources Information Center

    Gous, Ignatius G. P.; Roberts, Jennifer J.

    2015-01-01

    Management of time and workload is influenced by the quality of awareness of impacting factors. Faculty has to attend to many responsibilities, with technology in teaching a recent but game-changing impacting factor. This article is a case study which explores the metacognitive awareness of the impact of technology on teaching, learning and…

  3. Feasibility and Timing of Cytoreduction Surgery in Advanced (Metastatic or Recurrent) Gastrointestinal Stromal Tumors During the Era of Imatinib

    PubMed Central

    Chang, Shih-Chun; Liao, Chien-Hung; Wang, Shang-Yu; Tsai, Chun-Yi; Chiang, Kun-Chun; Cheng, Chi-Tung; Yeh, Ta-Sen; Chen, Yen-Yang; MA, Ming-Chun; Liu, Chien-Ting; Yeh, Chun-Nan

    2015-01-01

    Abstract The prognosis of advanced gastrointestinal stromal tumors (GISTs) was dramatically improved in the era of imatinib. Cytoreduction surgery was advocated as an additional treatment for advanced GISTs, especially when patients having poor response to imatinib or developing resistance to it. However, the efficacy and benefit of cytoreduction were still controversial. Likewise, the sequence between cytoreduction surgery and imatinib still need evaluation. In this study, we tried to assess the feasibility and efficiency of cytoreduction in advanced GISTs. Furthermore, we analyzed the impact of timing of the cytoreduction surgery on the prognosis of advanced GISTs. We conducted a prospective collecting retrospective review of patients with advanced GISTs (metastatic, unresectable, and recurrent GISTs) treated in Chang Gung memorial hospital (CGMH) since 2001 to 2013. We analyzed the impact of cytoreduction surgery to response to imatinib, progression-free survival (PFS), and overall survival (OS) in patients with advanced GISTs. Moreover, by the timing of cytoreduction to imatinib, we divided the surgical patients who had surgery before imatinib use into early group and those who had surgery after imatinib into late. We compared the clinical response to imatinib, PFS and OS between early and late cytoreduction surgical groups. Totally, 182 patients were enrolled into this study. Seventy-six patients underwent cytoreduction surgery. The demographic characteristics and tumor presentation were similar between surgical and non-surgical groups. The surgical group showed better complete response rate (P < 0.001) and partial response rate (P = 0.008) than non-surgical group. The 1-year, 3-year, and 5-year PFS were significantly superior in surgical group (P = 0.003). The 1-year, 3-year, and 5-year OS were superior in surgical group, but without statistical significance (P = 0.088). Dividing by cytoreduction surgical timing, the demographic

  4. Interferon Beta-1a Subcutaneous Injection

    MedlinePlus

    ... course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which ... under the skin). It is usually injected three times a week. You should inject this medication on ...

  5. The Timing of Arctic Sea Ice Advance and Retreat as an Indicator of Ice-Dependent Marine Mammal Habitat

    NASA Astrophysics Data System (ADS)

    Stern, H. L.; Laidre, K. L.

    2013-12-01

    The Arctic is widely recognized as the front line of climate change. Arctic air temperature is rising at twice the global average rate, and the sea-ice cover is shrinking and thinning, with total disappearance of summer sea ice projected to occur in a matter of decades. Arctic marine mammals such as polar bears, seals, walruses, belugas, narwhals, and bowhead whales depend on the sea-ice cover as an integral part of their existence. While the downward trend in sea-ice extent in a given month is an often-used metric for quantifying physical changes in the ice cover, it is not the most relevant measure for characterizing changes in the sea-ice habitat of marine mammals. Species that depend on sea ice are behaviorally tied to the annual retreat of sea ice in the spring and advance in the fall. Changes in the timing of the spring retreat and the fall advance are more relevant to Arctic marine species than changes in the areal sea-ice coverage in a particular month of the year. Many ecologically important regions of the Arctic are essentially ice-covered in winter and ice-free in summer, and will probably remain so for a long time into the future. But the dates of sea-ice retreat in spring and advance in fall are key indicators of climate change for ice-dependent marine mammals. We use daily sea-ice concentration data derived from satellite passive microwave sensors to calculate the dates of sea-ice retreat in spring and advance in fall in 12 regions of the Arctic for each year from 1979 through 2013. The regions include the peripheral seas around the Arctic Ocean (Beaufort, Chukchi, East Siberian, Laptev, Kara, Barents), the Canadian Arctic Archipelago, and the marginal seas (Okhotsk, Bering, East Greenland, Baffin Bay, Hudson Bay). We find that in 11 of the 12 regions (all except the Bering Sea), sea ice is retreating earlier in spring and advancing later in fall. Rates of spring retreat range from -5 to -8 days/decade, and rates of fall advance range from +5 to +9

  6. Temporal trends of time to antiretroviral treatment initiation, interruption and modification: examination of patients diagnosed with advanced HIV in Australia

    PubMed Central

    Wright, Stephen T; Law, Matthew G; Cooper, David A; Keen, Phillip; McDonald, Ann; Middleton, Melanie; Woolley, Ian; Kelly, Mark; Petoumenos, Kathy

    2015-01-01

    Introduction HIV prevention strategies are moving towards reducing plasma HIV RNA viral load in all HIV-positive persons, including those undiagnosed, treatment naïve, on or off antiretroviral therapy. A proxy population for those undiagnosed are patients that present late to care with advanced HIV. The objectives of this analysis are to examine factors associated with patients presenting with advanced HIV, and establish rates of treatment interruption and modification after initiating ART. Methods We deterministically linked records from the Australian HIV Observational Database to the Australian National HIV Registry to obtain information related to HIV diagnosis. Logistic regression was used to identify factors associated with advanced HIV diagnosis. We used survival methods to evaluate rates of ART initiation by diagnosis CD4 count strata and by calendar year of HIV diagnosis. Cox models were used to determine hazard of first ART treatment interruption (duration >30 days) and time to first major ART modification. Results Factors associated (p<0.05) with increased odds of advanced HIV diagnosis were sex, older age, heterosexual mode of HIV exposure, born overseas and rural–regional care setting. Earlier initiation of ART occurred at higher rates in later periods (2007–2012) in all diagnosis CD4 count groups. We found an 83% (69, 91%) reduction in the hazard of first treatment interruption comparing 2007–2012 versus 1996–2001 (p<0.001), and no difference in ART modification for patients diagnosed with advanced HIV. Conclusions Recent HIV diagnoses are initiating therapy earlier in all diagnosis CD4 cell count groups, potentially lowering community viral load compared to earlier time periods. We found a marked reduction in the hazard of first treatment interruption, and found no difference in rates of major modification to ART by HIV presentation status in recent periods. PMID:25865372

  7. Weekend-weekday advances in sleep timing are associated with altered reward-related brain function in healthy adolescents

    PubMed Central

    Hasler, Brant P.; Dahl, Ronald E.; Holm, Stephanie M.; Jakubcak, Jennifer L.; Ryan, Neal D.; Silk, Jennifer S.; Phillips, Mary L.; Forbes, Erika E.

    2012-01-01

    Sleep timing shifts later during adolescence, thus conflicting with early school start times. This can lead to irregular weekday-weekend schedules and circadian misalignment, which have been linked to depression and substance abuse, consistent with disruptions in the processing of rewards. We tested associations between weekend-weekday shifts in sleep timing and the neural response to monetary reward in healthy adolescents, using actigraphy and a functional magnetic resonance imaging paradigm. Region-of-interest analyses focused on the medial prefrontal cortex (mPFC) and striatum, both of which are implicated in reward function. Analyses adjusted for pubertal stage, sex, and total sleep time. Greater weekend-weekday advances in midsleep were associated with decreased mPFC and striatal reactivity to reward, which could reflect reduced regulatory response and reward sensitivity. We speculate that circadian misalignment associated with weekend shifts in sleep timing may contribute to reward-related problems such as depression and substance abuse. PMID:22960270

  8. Improvement in laboratory diagnosis of wound botulism and tetanus among injecting illicit-drug users by use of real-time PCR assays for neurotoxin gene fragments.

    PubMed

    Akbulut, D; Grant, K A; McLauchlin, J

    2005-09-01

    An upsurge in wound infections due to Clostridium botulinum and Clostridium tetani among users of illegal injected drugs (IDUs) occurred in the United Kingdom during 2003 and 2004. A real-time PCR assay was developed to detect a fragment of the neurotoxin gene of C. tetani (TeNT) and was used in conjunction with previously described assays for C. botulinum neurotoxin types A, B, and E (BoNTA, -B, and -E). The assays were sensitive, specific, rapid to perform, and applicable to investigating infections among IDUs using DNA extracted directly from wound tissue, as well as bacteria growing among mixed microflora in enrichment cultures and in pure culture on solid media. A combination of bioassay and PCR test results confirmed the clinical diagnosis in 10 of 25 cases of suspected botulism and two of five suspected cases of tetanus among IDUs. The PCR assays were in almost complete agreement with the conventional bioassays when considering results from different samples collected from the same patient. The replacement of bioassays by real-time PCR for the isolation and identification of both C. botulinum and C. tetani demonstrates a sensitivity and specificity similar to those of conventional approaches. However, the real-time PCR assays substantially improves the diagnostic process in terms of the speed of results and by the replacement of experimental animals. Recommendations are given for an improved strategy for the laboratory investigation of suspected wound botulism and tetanus among IDUs.

  9. Improvement in Laboratory Diagnosis of Wound Botulism and Tetanus among Injecting Illicit-Drug Users by Use of Real-Time PCR Assays for Neurotoxin Gene Fragments

    PubMed Central

    Akbulut, D.; Grant, K. A.; McLauchlin, J.

    2005-01-01

    An upsurge in wound infections due to Clostridium botulinum and Clostridium tetani among users of illegal injected drugs (IDUs) occurred in the United Kingdom during 2003 and 2004. A real-time PCR assay was developed to detect a fragment of the neurotoxin gene of C. tetani (TeNT) and was used in conjunction with previously described assays for C. botulinum neurotoxin types A, B, and E (BoNTA, -B, and -E). The assays were sensitive, specific, rapid to perform, and applicable to investigating infections among IDUs using DNA extracted directly from wound tissue, as well as bacteria growing among mixed microflora in enrichment cultures and in pure culture on solid media. A combination of bioassay and PCR test results confirmed the clinical diagnosis in 10 of 25 cases of suspected botulism and two of five suspected cases of tetanus among IDUs. The PCR assays were in almost complete agreement with the conventional bioassays when considering results from different samples collected from the same patient. The replacement of bioassays by real-time PCR for the isolation and identification of both C. botulinum and C. tetani demonstrates a sensitivity and specificity similar to those of conventional approaches. However, the real-time PCR assays substantially improves the diagnostic process in terms of the speed of results and by the replacement of experimental animals. Recommendations are given for an improved strategy for the laboratory investigation of suspected wound botulism and tetanus among IDUs. PMID:16145075

  10. Quantitative real-time monitoring of chemical reactions by autosampling flow injection analysis coupled with atmospheric pressure chemical ionization mass spectrometry.

    PubMed

    Zhu, Zhenqian; Bartmess, John E; McNally, Mary Ellen; Hoffman, Ron M; Cook, Kelsey D; Song, Liguo

    2012-09-04

    Although qualitative and/or semiquantitative real-time monitoring of chemical reactions have been reported with a few mass spectrometric approaches, to our knowledge, no quantitative mass spectrometric approach has been reported so far to have a calibration valid up to molar concentrations as required by process control. This is mostly due to the absence of a practical solution that could well address the sample overloading issue. In this study, a novel autosampling flow injection analysis coupled with an atmospheric pressure chemical ionization mass spectrometry (FIA/APCI-MS) system, consisting of a 1 μL automatic internal sample injector, a postinjection splitter with 1:10 splitting ratio, and a detached APCI source connected to the mass spectrometer using a 4.5 in. long, 0.042 in. inner diameter (ID) stainless-steel capillary, was thus introduced. Using this system together with an optional FIA solvent modifier, e.g., 0.05% (v/v) isopropylamine, a linear quantitative calibration up to molar concentration has been achieved with 3.4-7.2% relative standard deviations (RSDs) for 4 replicates. As a result, quantitative real-time monitoring of a model reaction was successfully performed at the 1.63 M level. It is expected that this novel autosampling FIA/APCI-MS system can be used in quantitative real-time monitoring of a wide range of reactions under diverse reaction conditions.

  11. Real-time monitoring of fragrance release from cotton towels by low thermal mass gas chromatography using a longitudinally modulating cryogenic system for headspace sampling and injection.

    PubMed

    Haefliger, Olivier P; Jeckelmann, Nicolas; Ouali, Lahoussine; León, Géraldine

    2010-01-15

    An innovative headspace sampling and injection system for gas chromatography was designed using a longitudinally modulating cryogenic system mounted around the sampling loop of a two-position loop injector. The setup was hyphenated to a fast low thermal mass gas chromatograph, allowing transient concentrations of semivolatile analytes to be monitored in real time with a time resolution of 4.5 min. The performance of the instrument, and in particular its cryotrapping efficiency, was characterized using a mixture of long-chain alkanes, methyl esters, ethyl esters, and alcohols of different volatilities. The device was found to be ideally suited to the analysis of semivolatile compounds with boiling points ranging between 190 and 320 degrees C, which are typical for a majority of perfumery raw materials. The new instrument was successfully used to monitor the release of eight odorant compounds from cotton towels to which fabric softener had been applied that alternatively contained the fragrance in free form or in microencapsulated form. The analytical results, unprecedented in their level of precision and time resolution for such an application, evidenced the major impact of microencapsulation technology on the kinetics of fragrance release during the drying of the towels and on the triggering of additional fragrance release by applying mechanical stress to the fabric to rupture the microcapsule walls.

  12. Design and implementation of a CO{sub 2} flood utilizing advanced reservoir characterization and horizontal injection wells in a shallow shelf carbonate approaching waterflood depletion

    SciTech Connect

    1996-08-09

    The first objective is to utilize reservoir characterization and advanced technologies to optimize the design of a carbon dioxide (CO{sub 2}) project for the South Cowden Unit (SCU) located in Ector County, Texas. The SCU is a mature, relatively small, shallow shelf carbonate unit nearing, waterflood depletion. The second objective is to demonstrate the performance and economic viability of the project in the field. This report includes work on the reservoir characterization and project design objective and the demonstration project objective.

  13. Design and Implementation of a CO2 Flood Utilizing Advanced Reservoir Characterization and Horizontal Injection Wells In a Shallow Shelf Carbonate Approaching Waterflood Depletion

    SciTech Connect

    Czirr, Kirk

    1999-10-28

    The first project objective is to utilize reservoir characterization and advanced technologies to optimize the design of a carbon dioxide (CO2) project for the South Cowden Unit (SCU) located in Ector County, Texas. The SCU is a mature, relatively small, shallow shelf carbonate unit nearing waterflood depletion. The second project objective is to demonstrate the performance and economic viability of the project in the field. All work during the second quarter falls within the demonstration project.

  14. A perfect time to harness advanced molecular technologies to explore the fundamental biology of Toxocara species.

    PubMed

    Gasser, Robin B

    2013-04-15

    Toxocarosis is of major canine health and socioeconomic importance worldwide. Although many studies have given insights into toxocarosis, to date, there has been limited exploration of the molecular biology, biochemistry, genetics, epidemiology and ecology of Toxocara species as well as parasite-host interactions using '-omic' technologies. The present article gives a background on Toxocara species and toxocarosis, describes molecular tools for specific identification and genetic analysis, and provides a prospective view of the benefits that advanced molecular technologies will have towards better understanding the parasites and disease. Tackling key biological questions employing a 'systems biology' approach should lead to new and improved strategies for the treatment, diagnosis and control of toxocarosis.

  15. Advances in Proteomics Data Analysis and Display Using an Accurate Mass and Time Tag Approach

    PubMed Central

    Zimmer, Jennifer S.D.; Monroe, Matthew E.; Qian, Wei-Jun; Smith, Richard D.

    2007-01-01

    Proteomics has recently demonstrated utility in understanding cellular processes on the molecular level as a component of systems biology approaches and for identifying potential biomarkers of various disease states. The large amount of data generated by utilizing high efficiency (e.g., chromatographic) separations coupled to high mass accuracy mass spectrometry for high-throughput proteomics analyses presents challenges related to data processing, analysis, and display. This review focuses on recent advances in nanoLC-FTICR-MS-based proteomics approaches and the accompanying data processing tools that have been developed to display and interpret the large volumes of data being produced. PMID:16429408

  16. Advances in high repetition rate, ultra-short, gigawatt laser systems for time-resolved spectroscopy

    SciTech Connect

    DiMauro, L.F.

    1991-12-31

    The objective of this article is to emphasize the current advances in the development of high-repetition rate amplifier pumps. Although this review highlights amplifier pump development, any recent data from achieved outputs via the tunable amplifier section is also discussed. The first section describes desirable parameters attributable to the pump amplifier while the rest of the article deals with specific examples for various options. The pump amplifiers can be characterized into two distinct classes; those achieving operation in the hundred hertz regime and those performing at repetition rates {ge}1kHz. 23 refs., 4 figs.

  17. Advances in high repetition rate, ultra-short, gigawatt laser systems for time-resolved spectroscopy

    SciTech Connect

    DiMauro, L.F.

    1991-01-01

    The objective of this article is to emphasize the current advances in the development of high-repetition rate amplifier pumps. Although this review highlights amplifier pump development, any recent data from achieved outputs via the tunable amplifier section is also discussed. The first section describes desirable parameters attributable to the pump amplifier while the rest of the article deals with specific examples for various options. The pump amplifiers can be characterized into two distinct classes; those achieving operation in the hundred hertz regime and those performing at repetition rates {ge}1kHz. 23 refs., 4 figs.

  18. Recent Advances in 3D Time-Resolved Contrast-Enhanced MR Angiography

    PubMed Central

    Riederer, Stephen J.; Haider, Clifton R.; Borisch, Eric A.; Weavers, Paul T.; Young, Phillip M.

    2015-01-01

    Contrast-enhanced MR angiography (CE-MRA) was first introduced for clinical studies approximately 20 years ago. Early work provided 3 to 4 mm spatial resolution with acquisition times in the 30 sec range. Since that time there has been continuing effort to provide improved spatial resolution with reduced acquisition time, allowing high resolution three-dimensional (3D) time-resolved studies. The purpose of this work is to describe how this has been accomplished. Specific technical enablers have been: improved gradients allowing reduced repetition times, improved k-space sampling and reconstruction methods, parallel acquisition particularly in two directions, and improved and higher count receiver coil arrays. These have collectively made high resolution time-resolved studies readily available for many anatomic regions. Depending on the application, approximate 1 mm isotropic resolution is now possible with frame times of several seconds. Clinical applications of time-resolved CE-MRA are briefly reviewed. PMID:26032598

  19. Constant versus variable response signal delays in speed--accuracy trade-offs: effects of advance preparation for processing time.

    PubMed

    Miller, Jeff; Sproesser, Gudrun; Ulrich, Rolf

    2008-07-01

    In two experiments, we used response signals (RSs) to control processing time and trace out speed--accuracy trade-off(SAT) functions in a difficult perceptual discrimination task. Each experiment compared performance in blocks of trials with constant and, hence, temporally predictable RS lags against performance in blocks with variable, unpredictable RS lags. In both experiments, essentially equivalent SAT functions were observed with constant and variable RS lags. We conclude that there is little effect of advance preparation for a given processing time, suggesting that the discrimination mechanisms underlying SAT functions are driven solely by bottom-up information processing in perceptual discrimination tasks.

  20. Advanced GPS-Based Time Link Calibration with PTB’s New GPS Calibration Setup

    DTIC Science & Technology

    2010-11-01

    and O. Koudelka, 2008, “Time transfer with nanosecond accuracy for the realization of International Atomic Time,” Metrologia , 45, 185- 198. [4] H...Observatory, Washington, D.C.), pp. 63-88. [14] P. Defraigne and G. Petit, 2004, “Time Transfer to TAI using geodetic receivers,” Metrologia , 40, 184-188

  1. Time-lapse integrated geophysical imaging of magmatic injections and fluid-induced fracturing causing Campi Flegrei 1983-84 Unrest

    NASA Astrophysics Data System (ADS)

    De Siena, Luca; Crescentini, Luca; Amoruso, Antonella; Del Pezzo, Edoardo; Castellano, Mario

    2016-04-01

    Geophysical precursors measured during Unrest episodes are a primary source of geophysical information to forecast eruptions at the largest and most potentially destructive volcanic calderas. Despite their importance and uniqueness, these precursors are also considered difficult to interpret and unrepresentative of larger eruptive events. Here, we show how novel geophysical imaging and monitoring techniques are instead able to represent the dynamic evolution of magmatic- and fluid-induced fracturing during the largest period of Unrest at Campi Flegrei caldera, Italy (1983-1984). The time-dependent patterns drawn by microseismic locations and deformation, once integrated by 3D attenuation tomography and absorption/scattering mapping, model injections of magma- and fluid-related materials in the form of spatially punctual microseismic bursts at a depth of 3.5 km, west and offshore the city of Pozzuoli. The shallowest four kilometres of the crust work as a deformation-based dipolar system before and after each microseismic shock. Seismicity and deformation contemporaneously focus on the point of injection; patterns then progressively crack the medium directed towards the second focus, a region at depths 1-1.5 km south of Solfatara. A single high-absorption and high-scattering aseismic anomaly marks zones of fluid storage overlying the first dipolar centre. These results provide the first direct geophysical signature of the processes of aseismic fluid release at the top of the basaltic basement, producing pozzolanic activity and recently observed via rock-physics and well-rock experiments. The microseismicity caused by fluids and gasses rises to surface via high-absorption north-east rising paths connecting the two dipolar centres, finally beingq being generally expelled from the maar diatreme Solfatara structure. Geophysical precursors during Unrest depict how volcanic stress was released at the Campi Flegrei caldera during its period of highest recorded seismicity

  2. Applications of advanced petroleum production technology and water alternating gas injection for enhanced oil recovery: Mattoon Oil Field, Illinois. Fourth quarterly report, [October 1, 1993--December 31, 1993

    SciTech Connect

    Baroni, M.

    1994-01-25

    The objectives of this project are to continue reservoir characterization of the Cypress Sandstone; to identify and map fades-defined waterflood units (FDWS); and to design and Implement water-alternating-gas (WAG) oil recovery utilizing carbon dioxide (CO{sub 2}). The producibility problems are permeability variation and poor sweep efficiency. Phase 1 of the project focuses on the development of computer-generated geological and reservoir simulation models that will be used to select sites for the demonstration and implementation of CO{sub 2} displacement programs in Phase 2. Included in Phase 1 is the site selection and drilling of an infill well, coring of the Cypress interval, and injectivity testing to gather information used to update the reservoir simulation model. Phase 2 involves field implementation of WAG. Technology Transfer includes outreach activity such as seminars, workshops, and field trips. Technical progress for this quarter is described.

  3. Applications of advanced petroleum production technology and water alternating gas injection for enhanced oil recovery: Mattoon Oil Field, Illinois. Third quarterly report, [July--September 1993

    SciTech Connect

    Baroni, M.R.

    1993-12-21

    The objectives of this project are to continue reservoir characterization of the Cypress Sandstone; to identify and map facies-defined waterflood units (FDWS); and to design and implement water-alternating-gas (WAG) oil recovery utilizing carbon dioxide (CO{sub 2}) The producibility problems are permeability variation and poor sweep efficiency. Part 1 of the project focuses on the development of computer-generated geological and reservoir simulation models that will be used to select sites for the demonstration and implementation of CO{sub 2} displacement programs in Part 2. Included in Part 1 is the site selection and drilling of an infill well, coring of the Cypress interval, and injectivity testing to gather information used to update the reservoir simulation model. Part 2 involves field implementation of WAG. Technology Transfer includes outreach activity such as seminars, workshops, and field trips.

  4. Pegaptanib Injection

    MedlinePlus

    ... if you have or have ever had diabetes, high blood pressure, a heart attack, or a stroke.tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using pegaptanib injection, ...

  5. Ramucirumab Injection

    MedlinePlus

    ... doctor if you have or have ever had high blood pressure, a wound that has not healed, or liver disease.tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Ramucirumab injection may harm your unborn baby. You ...

  6. Dexrazoxane Injection

    MedlinePlus

    ... are used to treat or prevent certain side effects that may be caused by chemotherapy medications. Dexrazoxane ... Dexrazoxane injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: pain or swelling in the place ...

  7. 41 CFR 301-71.306 - Are there exceptions to collecting an advance at the time the employee files a travel claim?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... collecting an advance at the time the employee files a travel claim? 301-71.306 Section 301-71.306 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...-71.306 Are there exceptions to collecting an advance at the time the employee files a travel...

  8. 41 CFR 301-71.306 - Are there exceptions to collecting an advance at the time the employee files a travel claim?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... collecting an advance at the time the employee files a travel claim? 301-71.306 Section 301-71.306 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...-71.306 Are there exceptions to collecting an advance at the time the employee files a travel...

  9. 41 CFR 301-52.14 - What must I do with any travel advance outstanding at the time I submit my travel claim?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... travel advance outstanding at the time I submit my travel claim? 301-52.14 Section 301-52.14 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES... § 301-52.14 What must I do with any travel advance outstanding at the time I submit my travel claim?...

  10. 41 CFR 301-71.306 - Are there exceptions to collecting an advance at the time the employee files a travel claim?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... collecting an advance at the time the employee files a travel claim? 301-71.306 Section 301-71.306 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...-71.306 Are there exceptions to collecting an advance at the time the employee files a travel...

  11. 41 CFR 301-52.14 - What must I do with any travel advance outstanding at the time I submit my travel claim?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... travel advance outstanding at the time I submit my travel claim? 301-52.14 Section 301-52.14 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES... § 301-52.14 What must I do with any travel advance outstanding at the time I submit my travel claim?...

  12. 41 CFR 301-71.306 - Are there exceptions to collecting an advance at the time the employee files a travel claim?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... collecting an advance at the time the employee files a travel claim? 301-71.306 Section 301-71.306 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...-71.306 Are there exceptions to collecting an advance at the time the employee files a travel...

  13. 41 CFR 301-71.306 - Are there exceptions to collecting an advance at the time the employee files a travel claim?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... collecting an advance at the time the employee files a travel claim? 301-71.306 Section 301-71.306 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES...-71.306 Are there exceptions to collecting an advance at the time the employee files a travel...

  14. 41 CFR 301-52.14 - What must I do with any travel advance outstanding at the time I submit my travel claim?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... travel advance outstanding at the time I submit my travel claim? 301-52.14 Section 301-52.14 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES... § 301-52.14 What must I do with any travel advance outstanding at the time I submit my travel claim?...

  15. 41 CFR 301-52.14 - What must I do with any travel advance outstanding at the time I submit my travel claim?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... travel advance outstanding at the time I submit my travel claim? 301-52.14 Section 301-52.14 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES... § 301-52.14 What must I do with any travel advance outstanding at the time I submit my travel claim?...

  16. 41 CFR 301-52.14 - What must I do with any travel advance outstanding at the time I submit my travel claim?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... travel advance outstanding at the time I submit my travel claim? 301-52.14 Section 301-52.14 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES... § 301-52.14 What must I do with any travel advance outstanding at the time I submit my travel claim?...

  17. Advances in the Geomagnetic Polarity Time Scale--Developments and Integration with the Geologic Time Scale and Future Directions (Invited)

    NASA Astrophysics Data System (ADS)

    Geissman, J. W.

    2013-12-01

    We celebrate the 50th anniversary of the publication of the Vine-Matthews/Morley-Larochelle hypothesis (Vine and Matthews, Nature, 1963, v. 199, #4897, p. 947-949), which integrated marine magnetic anomaly data with a rapidly evolving terrestrial-based geomagnetic polarity time scale (GPTS). The five decades of research since 1963 have witnessed the expansion and refinement of the GPTS, to the point where ages of magnetochron boundaries, in particular in the Cenozoic, can be estimated with uncertainties better than 0.1%. This has come about by integrating high precision geochronology, cyclostratigraphy at different time scales, and magnetic polarity data of increased quality, allowing extension of the GPTS back into the Paleozoic. The definition of a high resolution GPTS across time intervals of major events in Earth history has been of particular interest, as a specific magnetochron boundary correlated across several localities represents a singular global datum. A prime example is the end Permian, when some 80 percent of genus-level extinctions and a range of 75 to 96 percent species- level extinctions took place in the marine environment, depending upon clade. Much our understanding of the Permian-Triassic boundary (PTB) is based on relatively slowly deposited marine sequences in Europe and Asia, yet a growing body of observations from continental sequences demonstrates a similar extinction event and new polarity data from some of these sequences are critical to refining the GPTS across the PTB and testing synchronicity of marine and terrestrial events. The data show that the end-Permian ecological crisis and the conodont calibrated biostratigraphic PTB both followed a key polarity reversal between a short interval (subchron) of reverse polarity to a considerably longer (chron) of normal polarity. Central European Basin strata (continental Permian and epicontinental Triassic) yield high-quality magnetic polarity stratigraphic records (Szurlies et al., 2003

  18. Advanced instrument system for real-time and time-series microbial geochemical sampling of the deep (basaltic) crustal biosphere

    NASA Astrophysics Data System (ADS)

    Cowen, James P.; Copson, David A.; Jolly, James; Hsieh, Chih-Chiang; Lin, Huei-Ting; Glazer, Brian T.; Wheat, C. Geoffrey

    2012-03-01

    Integrated Ocean Drilling Program borehole CORK (Circulation Obviation Retrofit Kit) observatories provide long-term access to hydrothermal fluids circulating within the basaltic crust (basement), providing invaluable opportunities to study the deep biosphere. We describe the design and application parameters of the GeoMICROBE instrumented sled, an autonomous sensor and fluid sampling system. The GeoMICROBE system couples with CORK fluid delivery lines to draw large volumes of fluids from crustal aquifers to the seafloor. These fluids pass a series of in-line sensors and an in situ filtration and collection system. GeoMICROBE's major components include a primary valve manifold system, a positive displacement primary pump, sensors (e.g., fluid flow rate, temperature, dissolved O2, electrochemistry-voltammetry analyzer), a 48-port in situ filtration and fluid collection system, computerized controller, seven 24 V-40 A batteries and wet-mateable (ODI) communications with submersibles. This constantly evolving system has been successfully connected to IODP Hole 1301A on the eastern flank of the Juan de Fuca Ridge. Also described here is a mobile pumping system (MPS), which possesses many of the same components as the GeoMICROBE (e.g., pump, sensors, controller), but is directly powered and controlled in real time via submersible operations; the MPS has been employed repeatedly to collect pristine basement fluids for a variety of geochemical and microbial studies.

  19. Advanced time integration algorithms for dislocation dynamics simulations of work hardening

    NASA Astrophysics Data System (ADS)

    Sills, Ryan B.; Aghaei, Amin; Cai, Wei

    2016-05-01

    Efficient time integration is a necessity for dislocation dynamics simulations of work hardening to achieve experimentally relevant strains. In this work, an efficient time integration scheme using a high order explicit method with time step subcycling and a newly-developed collision detection algorithm are evaluated. First, time integrator performance is examined for an annihilating Frank-Read source, showing the effects of dislocation line collision. The integrator with subcycling is found to significantly out-perform other integration schemes. The performance of the time integration and collision detection algorithms is then tested in a work hardening simulation. The new algorithms show a 100-fold speed-up relative to traditional schemes. Subcycling is shown to improve efficiency significantly while maintaining an accurate solution, and the new collision algorithm allows an arbitrarily large time step size without missing collisions.

  20. Advanced time integration algorithms for dislocation dynamics simulations of work hardening

    DOE PAGES

    Sills, Ryan B.; Aghaei, Amin; Cai, Wei

    2016-04-25

    Efficient time integration is a necessity for dislocation dynamics simulations of work hardening to achieve experimentally relevant strains. In this work, an efficient time integration scheme using a high order explicit method with time step subcycling and a newly-developed collision detection algorithm are evaluated. First, time integrator performance is examined for an annihilating Frank–Read source, showing the effects of dislocation line collision. The integrator with subcycling is found to significantly out-perform other integration schemes. The performance of the time integration and collision detection algorithms is then tested in a work hardening simulation. The new algorithms show a 100-fold speed-up relativemore » to traditional schemes. As a result, subcycling is shown to improve efficiency significantly while maintaining an accurate solution, and the new collision algorithm allows an arbitrarily large time step size without missing collisions.« less

  1. Advanced time integration algorithms for dislocation dynamics simulations of work hardening

    SciTech Connect

    Sills, Ryan B.; Aghaei, Amin; Cai, Wei

    2016-04-25

    Efficient time integration is a necessity for dislocation dynamics simulations of work hardening to achieve experimentally relevant strains. In this work, an efficient time integration scheme using a high order explicit method with time step subcycling and a newly-developed collision detection algorithm are evaluated. First, time integrator performance is examined for an annihilating Frank–Read source, showing the effects of dislocation line collision. The integrator with subcycling is found to significantly out-perform other integration schemes. The performance of the time integration and collision detection algorithms is then tested in a work hardening simulation. The new algorithms show a 100-fold speed-up relative to traditional schemes. As a result, subcycling is shown to improve efficiency significantly while maintaining an accurate solution, and the new collision algorithm allows an arbitrarily large time step size without missing collisions.

  2. Advanced in Visualization of 3D Time-Dependent CFD Solutions

    NASA Technical Reports Server (NTRS)

    Lane, David A.; Lasinski, T. A. (Technical Monitor)

    1995-01-01

    Numerical simulations of complex 3D time-dependent (unsteady) flows are becoming increasingly feasible because of the progress in computing systems. Unfortunately, many existing flow visualization systems were developed for time-independent (steady) solutions and do not adequately depict solutions from unsteady flow simulations. Furthermore, most systems only handle one time step of the solutions individually and do not consider the time-dependent nature of the solutions. For example, instantaneous streamlines are computed by tracking the particles using one time step of the solution. However, for streaklines and timelines, particles need to be tracked through all time steps. Streaklines can reveal quite different information about the flow than those revealed by instantaneous streamlines. Comparisons of instantaneous streamlines with dynamic streaklines are shown. For a complex 3D flow simulation, it is common to generate a grid system with several millions of grid points and to have tens of thousands of time steps. The disk requirement for storing the flow data can easily be tens of gigabytes. Visualizing solutions of this magnitude is a challenging problem with today's computer hardware technology. Even interactive visualization of one time step of the flow data can be a problem for some existing flow visualization systems because of the size of the grid. Current approaches for visualizing complex 3D time-dependent CFD solutions are described. The flow visualization system developed at NASA Ames Research Center to compute time-dependent particle traces from unsteady CFD solutions is described. The system computes particle traces (streaklines) by integrating through the time steps. This system has been used by several NASA scientists to visualize their CFD time-dependent solutions. The flow visualization capabilities of this system are described, and visualization results are shown.

  3. Near Real-Time Nondestructive Active Inspection Technologies Utilizing Delayed γ-Rays and Neutrons for Advanced Safeguards

    SciTech Connect

    Hunt, Alan; Reedy, E. T.E.; Mozin, V.; Tobin, S. J.

    2015-02-12

    In this two year project, the research team investigated how delayed γ-rays from short-lived fission fragments detected in the short interval between irradiating pulses can be exploited for advanced safeguards technologies. This program contained experimental and modeling efforts. The experimental effort measured the emitted spectra, time histories and correlations of the delayed γ-rays from aqueous solutions and solid targets containing fissionable isotopes. The modeling effort first developed and benchmarked a hybrid Monte Carlo simulation technique based on these experiments. The benchmarked simulations were then extended to other safeguards scenarios, allowing comparisons to other advanced safeguards technologies and to investigate combined techniques. Ultimately, the experiments demonstrated the possible utility of actively induced delayed γ-ray spectroscopy for fissionable material assay.

  4. Advances in real-time magnetic resonance imaging of the vocal tract for speech science and technology research.

    PubMed

    Toutios, Asterios; Narayanan, Shrikanth S

    2016-01-01

    Real-time magnetic resonance imaging (rtMRI) of the moving vocal tract during running speech production is an important emerging tool for speech production research providing dynamic information of a speaker's upper airway from the entire mid-sagittal plane or any other scan plane of interest. There have been several advances in the development of speech rtMRI and corresponding analysis tools, and their application to domains such as phonetics and phonological theory, articulatory modeling, and speaker characterization. An important recent development has been the open release of a database that includes speech rtMRI data from five male and five female speakers of American English each producing 460 phonetically balanced sentences. The purpose of the present paper is to give an overview and outlook of the advances in rtMRI as a tool for speech research and technology development.

  5. Advances in real-time magnetic resonance imaging of the vocal tract for speech science and technology research

    PubMed Central

    TOUTIOS, ASTERIOS; NARAYANAN, SHRIKANTH S.

    2016-01-01

    Real-time magnetic resonance imaging (rtMRI) of the moving vocal tract during running speech production is an important emerging tool for speech production research providing dynamic information of a speaker's upper airway from the entire mid-sagittal plane or any other scan plane of interest. There have been several advances in the development of speech rtMRI and corresponding analysis tools, and their application to domains such as phonetics and phonological theory, articulatory modeling, and speaker characterization. An important recent development has been the open release of a database that includes speech rtMRI data from five male and five female speakers of American English each producing 460 phonetically balanced sentences. The purpose of the present paper is to give an overview and outlook of the advances in rtMRI as a tool for speech research and technology development. PMID:27833745

  6. Some Investigations on Hardness of Investment Casting Process After Advancements in Shell Moulding for Reduction in Cycle Time

    NASA Astrophysics Data System (ADS)

    Singh, R.; Mahajan, V.

    2014-07-01

    In the present work surface hardness investigations have been made on acrylonitrile butadiene styrene (ABS) pattern based investment castings after advancements in shell moulding for replication of biomedical implants. For the present study, a hip joint, made of ABS material, was fabricated as a master pattern by fused deposition modelling (FDM). After preparation of master pattern, mold was prepared by deposition of primary (1°), secondary (2°) and tertiary (3°) coatings with the addition of nylon fibre (1-2 cm in length of 1.5D). This study outlines the surface hardness mechanism for cast component prepared from ABS master pattern after advancement in shell moulding. The results of study highlight that during shell production, fibre modified shells have a much reduced drain time. Further the results are supported by cooling rate and micro structure analysis of casting.

  7. Advanced fluorescence microscopy methods for the real-time study of transcription and chromatin dynamics

    PubMed Central

    Annibale, Paolo; Gratton, Enrico

    2014-01-01

    In this contribution we provide an overview of the recent advances allowed by the use of fluorescence microscopy methods in the study of transcriptional processes and their interplay with the chromatin architecture in living cells. Although the use of fluorophores to label nucleic acids dates back at least to about half a century ago,1 two recent breakthroughs have effectively opened the way to use fluorescence routinely for specific and quantitative probing of chromatin organization and transcriptional activity in living cells: namely, the possibility of labeling first the chromatin loci and then the mRNA synthesized from a gene using fluorescent proteins. In this contribution we focus on methods that can probe rapid dynamic processes by analyzing fast fluorescence fluctuations. PMID:25764219

  8. The real-time learning mechanism of the Scientific Research Associates Advanced Robotic System (SRAARS)

    NASA Technical Reports Server (NTRS)

    Chen, Alexander Y.

    1990-01-01

    Scientific research associates advanced robotic system (SRAARS) is an intelligent robotic system which has autonomous learning capability in geometric reasoning. The system is equipped with one global intelligence center (GIC) and eight local intelligence centers (LICs). It controls mainly sixteen links with fourteen active joints, which constitute two articulated arms, an extensible lower body, a vision system with two CCD cameras and a mobile base. The on-board knowledge-based system supports the learning controller with model representations of both the robot and the working environment. By consecutive verifying and planning procedures, hypothesis-and-test routines and learning-by-analogy paradigm, the system would autonomously build up its own understanding of the relationship between itself (i.e., the robot) and the focused environment for the purposes of collision avoidance, motion analysis and object manipulation. The intelligence of SRAARS presents a valuable technical advantage to implement robotic systems for space exploration and space station operations.

  9. Adaptive engine injection for emissions reduction

    DOEpatents

    Reitz, Rolf D. : Sun, Yong

    2008-12-16

    NOx and soot emissions from internal combustion engines, and in particular compression ignition (diesel) engines, are reduced by varying fuel injection timing, fuel injection pressure, and injected fuel volume between low and greater engine loads. At low loads, fuel is injected during one or more low-pressure injections occurring at low injection pressures between the start of the intake stroke and approximately 40 degrees before top dead center during the compression stroke. At higher loads, similar injections are used early in each combustion cycle, in addition to later injections which preferably occur between about 90 degrees before top dead center during the compression stroke, and about 90 degrees after top dead center during the expansion stroke (and which most preferably begin at or closely adjacent the end of the compression stroke). These later injections have higher injection pressure, and also lower injected fuel volume, than the earlier injections.

  10. Nivolumab Injection

    MedlinePlus

    ... with ipilimumab (Yervoy) to treat certain types of melanoma (a type of skin cancer) that has spread ... facility. When nivolumab is given alone to treat melanoma, lung cancer, or advanced RCC, it is usually ...

  11. Oxaliplatin Injection

    MedlinePlus

    ... other medications to treat advanced colon or rectal cancer (cancer that begins in the large intestine). Oxaliplatin is also used with other medications to prevent colon cancer from spreading in people who have had surgery ...

  12. NSTX-U Advances in Real-Time C++11 on Linux

    SciTech Connect

    Erickson, Keith G.

    2015-08-14

    Programming languages like C and Ada combined with proprietary embedded operating systems have dominated the real-time application space for decades. The new C++11standard includes native, language-level support for concurrency, a required feature for any nontrivial event-oriented real-time software. Threads, Locks, and Atomics now exist to provide the necessary tools to build the structures that make up the foundation of a complex real-time system. The National Spherical Torus Experiment Upgrade (NSTX-U) at the Princeton Plasma Physics Laboratory (PPPL) is breaking new ground with the language as applied to the needs of fusion devices. A new Digital Coil Protection System (DCPS) will serve as the main protection mechanism for the magnetic coils, and it is written entirely in C++11 running on Concurrent Computer Corporation's real-time operating system, RedHawk Linux. It runs over 600 algorithms in a 5 kHz control loop that determine whether or not to shut down operations before physical damage occurs. To accomplish this, NSTX-U engineers developed software tools that do not currently exist elsewhere, including real-time atomic synchronization, real-time containers, and a real-time logging framework. Together with a recent (and carefully configured) version of the GCC compiler, these tools enable data acquisition, processing, and output using a conventional operating system to meet a hard real-time deadline (that is, missing one periodic is a failure) of 200 microseconds.

  13. NSTX-U Advances in Real-Time C++11 on Linux

    DOE PAGES

    Erickson, Keith G.

    2015-08-14

    Programming languages like C and Ada combined with proprietary embedded operating systems have dominated the real-time application space for decades. The new C++11standard includes native, language-level support for concurrency, a required feature for any nontrivial event-oriented real-time software. Threads, Locks, and Atomics now exist to provide the necessary tools to build the structures that make up the foundation of a complex real-time system. The National Spherical Torus Experiment Upgrade (NSTX-U) at the Princeton Plasma Physics Laboratory (PPPL) is breaking new ground with the language as applied to the needs of fusion devices. A new Digital Coil Protection System (DCPS) willmore » serve as the main protection mechanism for the magnetic coils, and it is written entirely in C++11 running on Concurrent Computer Corporation's real-time operating system, RedHawk Linux. It runs over 600 algorithms in a 5 kHz control loop that determine whether or not to shut down operations before physical damage occurs. To accomplish this, NSTX-U engineers developed software tools that do not currently exist elsewhere, including real-time atomic synchronization, real-time containers, and a real-time logging framework. Together with a recent (and carefully configured) version of the GCC compiler, these tools enable data acquisition, processing, and output using a conventional operating system to meet a hard real-time deadline (that is, missing one periodic is a failure) of 200 microseconds.« less

  14. Managing Institutional Research Advancement: Implications from a University Faculty Time Allocation Study

    ERIC Educational Resources Information Center

    Anderson, Derrick M.; Slade, Catherine P.

    2016-01-01

    While much is known about faculty time allocation, we know very little about how traditional managerial factors influence faculty time allocation behaviors. We know even less about the possible downsides associated with relying on these traditional managerial factors. Using survey data from the National Science Foundation/Department of Energy…

  15. Design and Implementation of a CO(2) Flood Utilizing Advanced Reservoir Characterization and Horizontal Injection Wells in Shallow Shelf Carbonate Approaching Waterflood Depletion

    SciTech Connect

    1997-12-31

    The work reported herein covers select tasks in Budget Phase 11. The principle Task in Budget Phase 11 included in this report is Field Demonstration. Completion of many of the Field Demonstration tasks during the last report period enabled an optimum carbon dioxide (CO{sub 2}) flood project to be designed, economically evaluated, and implemented in the field. Field implementation of the project commenced during late 1995, with actual C0{sub 2} injection commencing in mid-July, 1996. This report summarizes activities incurred following initial project start-up, towards the goal of optimizing project performance. The current project has focused on reducing initial investment cost by utilizing horizontal injection wells and concentrating the project in the best productivity area of the field. An innovative C0{sub 2} purchase agreement (no take-or-pay provisions, C0{sub 2} purchase price tied to West Texas Intermediate (WTI) crude oil price) and gas recycle agreement (expensing costs as opposed to a large upfront capital investment for compression) were negotiated to further improve the project economics. The Grayburg-San Andres section had previously been divided into multiple zones based on the core study and gamma ray markers that correlate wells within the Unit. Each zone was mapped as continuous across the field. Previous core studies concluded that the reservoir quality in the South Cowden Unit (SCU) is controlled primarily by the distribution of a bioturbated and diagenetically-altered rock type with a distinctive chaotic texture. The chaotic modifier is derived from the visual effect of pervasive, small-scale intermixing of tan oil-stained reservoir rock with tight gray non- reservoir rock. The chaotic reservoir rock extends from Zone C (4780`-4800`) to the lower part of Zone F (4640`-4680`). Zones D (4755`-4780`) and E (4680`-4755`) are considered the main floodable zones, though Zone F is also productive and Zone C is productive above the oil- water contact

  16. Non-Intrusive Device for Real-Time Circulatory System Assessment with Advanced Signal Processing Capabilities

    NASA Astrophysics Data System (ADS)

    Pinheiro, E.; Postolache, O.; Girão, P.

    2010-01-01

    This paper presents a device that uses three cardiography signals to characterize several important parameters of a subject's circulatory system. Using electrocardiogram, finger photoplethysmogram, and ballistocardiogram, three heart rate estimates are acquired from beat-to-beat time interval extraction. Furthermore, pre-ejection period, pulse transit time (PTT), and pulse arrival time (PAT) are computed, and their long-term evolution is analyzed. The system estimates heart rate variability (HRV) and blood pressure variability (BPV) from the heart rate and PAT time series, to infer the activity of the cardiac autonomic system. The software component of the device evaluates the frequency content of HRV and BPV, and also their fractal dimension and entropy, thus providing a detailed analysis of the time series' regularity and complexity evolution, to allow personalized subject evaluation.

  17. Simulation studies of time-control procedures for the advanced air traffic control system

    NASA Technical Reports Server (NTRS)

    Tobias, L.; Alcabin, M.; Erzberger, H.; Obrien, P. J.

    1985-01-01

    The problem of mixing aircraft equipped with time-controlled guidance systems and unequipped aircraft in the terminal area has been investigated via a real-time air traffic control simulation. These four-dimensional (4D) guidance systems can predict and control the touchdown time of an aircraft to an accuracy of a few seconds throughout the descent. The objectives of this investigation were to (1) develop scheduling algorithms and operational procedures for various traffic mixes that ranged from 25% to 75% 4D-equipped aircraft; (2) examine the effect of time errors at 120 n. mi. from touchdown on touchdown time scheduling of the various mix conditions; and (3) develop efficient algorithms and procedures to null the initial time errors prior to reaching the final control sector, 30 n. mi. from touchdown. Results indicate substantial reduction in controller workload and an increase in orderliness when more than 25% of the aircraft are equipped with 4D guidance systems; initial random errors of up to + or - 2 min can be handled via a single speed advisory issued in the arrival control sector, thus avoiding disruption of the time schedule.

  18. Advanced manpower and time saving testing concept for development, production, and maintenance of electro-optical systems

    NASA Astrophysics Data System (ADS)

    Cabib, Dario; Buckwald, R. A.; Nirkin, Shimon; Lavi, Moshe; Neria, Oded; Ben Yaakov, Claudia; Tzafrir, Efraim; Blau, Moshe; Dolev, Jacob

    2006-05-01

    In all stages of an electro-optics system's life, development, production, and periodic maintenance, a large amount of manpower and time is devoted to testing. Each subsystem separately as well as the system as a whole are tested by a PC controlled test system, which consists of hardware for creation of the appropriate stimuli, and software for tests management and control. A very considerable portion of this manpower and time is devoted by the system manufacturer to configure the test routines, to manually input certain parameter values of the Unit Under Test (UUT) at predefined test nodes, and to reconfigure these routines from time to time, as the needs change during the system's life time. CI has developed the CTE (CI Test Executive), a software package which is a breakthrough in saving manpower and time devoted to electro-optics system testing. The new concept is based on: 1. The CTE can communicate directly with any UUT able to communicate with the outside world through a known protocol, to automatically set the UUT parameters before testing, 2. The user can more easily reconfigure the communication with the UUT through a provided special Excel file, without the help of the test system manufacturer, 3. The interface screen is automatically reconfigured every time the Excel file is changed to build the new test routine, 4. The CTE can simulate the test system stimuli with error injection capability, and simultaneously monitor communication and other hardware functions, 5. Test "verification" signals are provided on-line for the convenience and time saving of the test operator.

  19. Time-frequency and advanced frequency estimation techniques for the investigation of bat echolocation calls.

    PubMed

    Kopsinis, Yannis; Aboutanios, Elias; Waters, Dean A; McLaughlin, Steve

    2010-02-01

    In this paper, techniques for time-frequency analysis and investigation of bat echolocation calls are studied. Particularly, enhanced resolution techniques are developed and/or used in this specific context for the first time. When compared to traditional time-frequency representation methods, the proposed techniques are more capable of showing previously unseen features in the structure of bat echolocation calls. It should be emphasized that although the study is focused on bat echolocation recordings, the results are more general and applicable to many other types of signal.

  20. Advances in interpretation of subsurface processes with time-lapse electrical imaging

    SciTech Connect

    Singha, Kamini; Day-Lewis, Frederick D.; Johnson, Timothy C.; Slater, Lee D.

    2015-03-15

    Electrical geophysical methods, including electrical resistivity, time-domain induced polarization, and complex resistivity, have become commonly used to image the near subsurface. Here, we outline their utility for time-lapse imaging of hydrological, geochemical, and biogeochemical processes, focusing on new instrumentation, processing, and analysis techniques specific to monitoring. We review data collection procedures, parameters measured, and petrophysical relationships and then outline the state of the science with respect to inversion methodologies, including coupled inversion. We conclude by highlighting recent research focused on innovative applications of time-lapse imaging in hydrology, biology, ecology, and geochemistry, among other areas of interest.

  1. Recent advances on a DGTD method for time-domain electromagnetics

    NASA Astrophysics Data System (ADS)

    Descombes, Stéphane; Durochat, Clément; Lanteri, Stéphane; Moya, Ludovic; Scheid, Claire; Viquerat, Jonathan

    2013-11-01

    During the last ten years, the discontinuous Galerkin time-domain (DGTD) method has progressively emerged as a viable alternative to well established finite-difference time-domain (FDTD) and finite-element time-domain (FETD) methods for the numerical simulation of electromagnetic wave propagation problems in the time-domain. In this paper, we review the historical development of the DGTD method and emphasize its recent adoption by the nanophotonic research community. In addition, we discuss about some of our recent efforts aiming at improving the accuracy, flexibility and efficiency of a non-dissipative order DGTD method, and also report on some preliminary works towards its extension to the numerical treatment of physical models and problems that are relevant to nanophotonics.

  2. Rain underscores need for injection

    SciTech Connect

    Stelling, K.F.

    1996-01-01

    Since 1987, steam production totals at The Geysers Geothermal field have fallen and water injection totals have remained quite stable, except for the unusually dry winter months of 1994 when injection fell by a record amount. The heavy rainfall in the first half of 1995 altered the long-term production and injection patterns and underscored the need to increase injection in the field. From January to June 1995, steam production at The Geysers was reduced by 37 percent form the amount produced during the same period in 1994--because the rain increased availability of hydroelectric power. At the same time, water injection in the field rose by 25 percent because more rainwater was available for injection. Consequently, both reservoir pressure and available steam reserves grew, and most power plants that returned on line in the second half of the year produced more megawatts with less steam. This confirmed findings form several injection studies at The Geyser`s.

  3. The Effect of Time-Advance Mechanism in Modeling and Simulation

    DTIC Science & Technology

    2011-09-01

    57  Figure 13.  Event Graph for multiple server queue M/M/k (Buss, 2001) ..........................61  Figure 14.  DES model output measures : a...Figure 15.  DTS model output measures with different time steps: a) average number in system behavior b) time in system behavior...Graph for multiple server queue M/M/k/c with balking........................73  Figure 20.  Output measures for DES, DTS and analytical solution for M

  4. Optimizing spinning time-domain gravitational waveforms for Advanced LIGO data analysis

    NASA Astrophysics Data System (ADS)

    Etienne, Zachariah; Devine, Caleb; McWilliams, Sean

    2016-03-01

    The Spinning Effective One Body--Numerical Relativity (SEOBNR) series of gravitational wave approximants are among the best available for Advanced LIGO data analysis. Unfortunately, SEOBNR codes as they currently exist within LALSuite are generally too slow to be directly useful for standard Markov-Chain Monte Carlo-based parameter estimation (PE). Reduced-Order Models (ROMs) of SEOBNR have been developed for this purpose, but there is no known way to make ROMs of the full eight-dimensional parameter space more efficient for PE than the SEOBNR codes directly. So as a proof of principle, we have sped up the original LALSuite SEOBNRv2 approximant code, which models waveforms from aligned-spin systems, by about 280x. Our optimized code shortens the timescale for conducting PE with this approximant to months, assuming a purely serial analysis, so that even modest parallelization combined with our optimized code will make running the full PE pipeline with SEOBNR codes directly a realistic possibility. A number of our SEOBNRv2 optimizations have already been applied to SEOBNRv3, a new approximant capable of modeling sources with all eight intrinsic degrees of freedom. We anticipate that once all of our optimizations have been applied to SEOBNRv3, a similar speed-up will be achieved.

  5. Optimizing spinning time-domain gravitational waveforms for advanced LIGO data analysis

    NASA Astrophysics Data System (ADS)

    Devine, Caleb; Etienne, Zachariah B.; McWilliams, Sean T.

    2016-06-01

    The spinning effective-one-body-numerical relativity (SEOBNR) series of gravitational wave approximants are among the best available for advanced LIGO data analysis. Unfortunately, SEOBNR codes as they currently exist within LALSuite are generally too slow to be directly useful for standard Markov-chain Monte Carlo-based parameter estimation (PE). Reduced-order models (ROMs) of SEOBNR have been developed for this purpose, but there is no known way to make ROMs of the full eight-dimensional intrinsic parameter space more efficient for PE than the SEOBNR codes directly. So as a proof of principle, we have sped up the original LALSuite SEOBNRv2 approximant code, which models waveforms from aligned-spin systems, by nearly 300x. Our optimized code shortens the timescale for conducting PE with this approximant to months, assuming a purely serial analysis, so that even modest parallelization combined with our optimized code will make running the full PE pipeline with SEOBNR codes directly a realistic possibility. A number of our SEOBNRv2 optimizations have already been applied to SEOBNRv3, a new approximant capable of modeling sources with all eight (precessing) intrinsic degrees of freedom. We anticipate that once all of our optimizations have been applied to SEOBNRv3, a similar speed-up may be achieved.

  6. Research and development program for non-linear structural modeling with advanced time-temperature dependent constitutive relationships

    NASA Technical Reports Server (NTRS)

    Walker, K. P.

    1981-01-01

    Results of a 20-month research and development program for nonlinear structural modeling with advanced time-temperature constitutive relationships are reported. The program included: (1) the evaluation of a number of viscoplastic constitutive models in the published literature; (2) incorporation of three of the most appropriate constitutive models into the MARC nonlinear finite element program; (3) calibration of the three constitutive models against experimental data using Hastelloy-X material; and (4) application of the most appropriate constitutive model to a three dimensional finite element analysis of a cylindrical combustor liner louver test specimen to establish the capability of the viscoplastic model to predict component structural response.

  7. Design of a magnetic shielding system for the time of flight enhanced diagnostics neutron spectrometer at Experimental Advanced Superconducting Tokamak.

    PubMed

    Cui, Z Q; Chen, Z J; Xie, X F; Peng, X Y; Hu, Z M; Du, T F; Ge, L J; Zhang, X; Yuan, X; Xia, Z W; Hu, L Q; Zhong, G Q; Lin, S Y; Wan, B N; Fan, T S; Chen, J X; Li, X Q; Zhang, G H

    2014-11-01

    The novel neutron spectrometer TOFED (Time of Flight Enhanced Diagnostics), comprising 90 individual photomultiplier tubes coupled with 85 plastic scintillation detectors through light guides, has been constructed and installed at Experimental Advanced Superconducting Tokamak. A dedicated magnetic shielding system has been constructed for TOFED, and is designed to guarantee the normal operation of photomultiplier tubes in the stray magnetic field leaking from the tokamak device. Experimental measurements and numerical simulations carried out employing the finite element method are combined to optimize the design of the magnetic shielding system. The system allows detectors to work properly in an external magnetic field of 200 G.

  8. Highway Subsidence Analysis Based on the Advanced InSAR Time Series Analysis Method

    NASA Astrophysics Data System (ADS)

    Zhang, Qingyun; Zhang, Jingfa; Liu, Guolin; Li, Yongsheng

    2016-08-01

    The synthetic aperture radar (InSAR) measurements have the advantages of all-weather, wide range, high precision on the surface deformation monitoring. Highway as an important index of modern social and economic development, the quality and deformation changes in the process of using have a significant impact in the social development and people's life and property security. In practical applications the InSAR technology should do a variety of error correction analysis. By using a new analysis method – FRAM- SBAS time-series analysis method, to analyze the settlement of highway on Yanzhou area by the ALOS PALSAR datas. Use FRAM- SBAS timing analysis method to obtain the surface timing changes during 2008-09-21 to 2010-07-18 in the Jining area and obtained good results, the Jining area maximum timing settlement is 60mm, the maximum settlement rate reached 30mm/yr. The maximum settlement of the highway section is 53mm, the maximum settlement rate is 32mm/yr. And the settlement of highway worst sections were in severe ground subsidence, thus proving the mining and vehicle load effect on settlement of highway. And it is proved that the timing method on the ground and highway subsidence monitoring is feasible.

  9. Effect of the photoperiod on the time schedule of egg mass production in Lymnaea stagnalis, as induced by ovulation hormone injections.

    PubMed

    Dogterom, G E; Bohlken, S; Joosse, J

    1983-02-01

    In the pulmonate snail Lymnaea stagnalis the neurosecretory caudo-dorsal cells (CDC) produce an ovulation hormone (CDCH) which is released at the periphery of the cerebral commissure (COM). Time schedules of the successive stages of the egg mass production following CDCH injection (COM extract) were determined at 20 degrees. Ovulation is performed rapidly, within 10 to 20 min. The latencies of the other stages are: egg formation, 20-30 min; egg mass formation, 60-90 min; and oviposition, about 120 min. The duration of oviposition is dependent on the size of the egg mass and varies from 5 to 20 min. At a 16-hr photoperiod all stages start 10 min earlier than at a 12-hr photoperiod. It is suggested that the effect of the photoperiod is achieved by a change of release activities of dorsal bodies and/or of CDC. The possibility that a nervous mechanism is involved in the control of the packaging of the egg cells is discussed.

  10. Advanced Visualization of Experimental Data in Real Time Using LiveView3D

    NASA Technical Reports Server (NTRS)

    Schwartz, Richard J.; Fleming, Gary A.

    2006-01-01

    LiveView3D is a software application that imports and displays a variety of wind tunnel derived data in an interactive virtual environment in real time. LiveView3D combines the use of streaming video fed into a three-dimensional virtual representation of the test configuration with networked communications to the test facility Data Acquisition System (DAS). This unified approach to real time data visualization provides a unique opportunity to comprehend very large sets of diverse forms of data in a real time situation, as well as in post-test analysis. This paper describes how LiveView3D has been implemented to visualize diverse forms of aerodynamic data gathered during wind tunnel experiments, most notably at the NASA Langley Research Center Unitary Plan Wind Tunnel (UPWT). Planned future developments of the LiveView3D system are also addressed.

  11. The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity

    PubMed Central

    Cousminer, Diana L.; Widén, Elisabeth; Palmert, Mark R.

    2016-01-01

    Purpose of review To overview advances in the genetics of puberty based on studies in the general population, describe evidence for sex-specific genetic effects on pubertal timing, and briefly review possible mechanisms mediating sexually dimorphic genetic effects. Recent findings Pubertal timing is highly polygenic, and many loci are conserved among ethnicities. A number of identified loci underlie both pubertal timing and related traits such as height and body mass index (BMI). It is increasingly apparent that understanding the factors modulating the onset of puberty is important because the timing of this developmental stage is associated with a wider range of adult health outcomes than previously appreciated. While most of the genetic effects underlying the timing of puberty are common between boys and girls, some effects show sex-specificity and many are epigenetically modulated. Several potential mechanisms, including hormone-independent ones, may be responsible for observed sex differences. Summary Studies of pubertal timing in the general population have provided new knowledge about the genetic architecture of this complex trait. Increasing attention paid to sex-specific effects may provide key insights into the sexual dimorphism in pubertal timing and even into the associations between puberty and adult health risks by identifying common underlying biological pathways. PMID:26574646

  12. Planar solid phase extraction clean-up and microliter-flow injection analysis-time-of-flight mass spectrometry for multi-residue screening of pesticides in food.

    PubMed

    Oellig, Claudia; Schwack, Wolfgang

    2014-07-18

    For multi-residue analysis of pesticides in food, a sufficient clean-up is essential for avoiding matrix effects in liquid and gas chromatography (LC and GC) analysis coupled to mass spectrometry (MS). In the last two years, high-throughput planar solid phase extraction (HTpSPE) was established as a new clean-up concept for pesticide residue analysis in fruits and vegetables (C. Oellig, W. Schwack, 2011) and tea (C. Oellig, W. Schwack, 2012). HTpSPE results in matrix-free extracts almost free of interferences and matrix effects. In this study, a time-of-flight mass spectrometer (TOFMS) was applied to directly analyze HTpSPE extracts for pesticide residues. This HTpSPE-microliter-flow injection analysis (μL-FIA)-TOFMS approach detects all pesticides at once in a single mass spectrum, without a liquid chromatographic separation step. Complete sample information was obtained after the injection of the cleaned extract within a single peak. Recovery studies for seven representative pesticides in four different matrices (apples, red grapes, cucumbers, tomatoes) provided mean recoveries of 86-116% with relative standard deviations of 1.3-10% (n=5) using the mass signal intensities under the entire sample peak. Comparing the mass spectra of sample peaks from spiked extracts and solvent standards indicated the efficiency of HTpSPE clean-up. A pesticide database search detected all spiked pesticides with a low incidence of false-positives. HTpSPE of one sample required a few minutes, and numerous samples could be cleaned in parallel at minimal cost with low sample and solvent consumption. The μL-FIA-TOFMS screening then needed an additional 6min per sample. The novel screening approach was successfully applied to QuEChERS extracts of several real samples, and the pesticides identified by HTpSPE-μL-FIA-TOFMS were identical to the pesticides detected by common target LC-MS/MS analyses. The high degree of concordantly identified pesticides by the new developed HTp

  13. Injectable barriers for waste isolation

    SciTech Connect

    Persoff, P.; Finsterle, S.; Moridis, G.J.; Apps, J.; Pruess, K.; Muller, S.J.

    1995-03-01

    In this paper the authors report laboratory work and numerical simulation done in support of development and demonstration of injectable barriers formed from either of two fluids: colloidal silica or polysiloxane. Two principal problems addressed here are control of gel time and control of plume emplacement in the vadose zone. Gel time must be controlled so that the viscosity of the barrier fluid remains low long enough to inject the barrier, but increases soon enough to gel the barrier in place. During injection, the viscosity must be low enough to avoid high injection pressures which could uplift or fracture the formation. To test the grout gel time in the soil, the injection pressure was monitored as grouts were injected into sandpacks. When grout is injected into the vadose zone, it slumps under the influence of gravity, and redistributes due to capillary forces as it gels. The authors have developed a new module for the reservoir simulator TOUGH2 to model grout injection into the vadose zone, taking into account the increase of liquid viscosity as a function of gel concentration and time. They have also developed a model to calculate soil properties after complete solidification of the grout. The numerical model has been used to design and analyze laboratory experiments and field pilot tests. The authors present the results of computer simulations of grout injection, redistribution, and solidification.

  14. Some Factors Controlling the Seismic Hazard due to Earthquakes Induced by Fluid Injection at Depth

    NASA Astrophysics Data System (ADS)

    McGarr, A.

    2012-12-01

    The maximum seismic moment (or moment magnitude) is an important measure of the seismic hazard associated with earthquakes induced by deep fluid injection. Although it would be advantageous to be able to predict the induced earthquake outcome, including the maximum seismic moment, of a specified fluid injection project in advance, this capability has, to date, proved to be elusive because the geomechanical and hydrological factors that control the seismic response to injection are too poorly understood. Fortunately, the vast majority of activities involving the injection of fluids into deep aquifers do not cause earthquakes that are large enough to be of any consequence. There have been, however, significant exceptions during the past 50 years, starting with the earthquakes induced by injection of wastewater at the Rocky Mountain Arsenal Well, during the 1960s, that caused extensive damage in the Denver, CO, area. Results from numerous case histories of earthquakes induced by injection activities, including wastewater disposal at depth and the development of enhanced geothermal systems, suggest that it may be feasible to estimate bounds on maximum magnitudes based on the volume of injected liquid. For these cases, volumes of injected liquid ranged from approximately 11.5 thousand to 5 million cubic meters and resulted in main shock moment magnitudes from 3.4 to 5.3. Because the maximum seismic moment appears to be linearly proportional to the total volume of injected fluid, this upper bound is expected to increase with time as long as a given injection well remains active. For example, in the Raton Basin, southern Colorado and northern New Mexico, natural gas is produced from an extensive coal bed methane field. The deep injection of wastewater associated with this gas production has induced a sequence of earthquakes starting in August 2001, shortly after the beginning of major injection activities. Most of this seismicity defines a northeast striking plane dipping

  15. A real-time implementation of an advanced sensor failure detection, isolation, and accommodation algorithm

    NASA Technical Reports Server (NTRS)

    Delaat, J. C.; Merrill, W. C.

    1983-01-01

    A sensor failure detection, isolation, and accommodation algorithm was developed which incorporates analytic sensor redundancy through software. This algorithm was implemented in a high level language on a microprocessor based controls computer. Parallel processing and state-of-the-art 16-bit microprocessors are used along with efficient programming practices to achieve real-time operation.

  16. Predictive transport simulations of real-time profile control in JET advanced tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Tala, T.; Laborde, L.; Mazon, D.; Moreau, D.; Corrigan, G.; Crisanti, F.; Garbet, X.; Heading, D.; Joffrin, E.; Litaudon, X.; Parail, V.; Salmi, A.; EFDA-JET workprogramme, contributors to the

    2005-09-01

    Predictive, time-dependent transport simulations with a semi-empirical plasma model have been used in closed-loop simulations to control the q-profile and the strength and location of the internal transport barrier (ITB). Five transport equations (Te, Ti, q, ne, vΦ) are solved, and the power levels of lower hybrid current drive, NBI and ICRH are calculated in a feedback loop determined by the feedback controller matrix. The real-time control (RTC) technique and algorithms used in the transport simulations are identical to those implemented and used in JET experiments (Laborde L. et al 2005 Plasma Phys. Control. Fusion 47 155 and Moreau D. et al 2003 Nucl. Fusion 43 870). The closed-loop simulations with RTC demonstrate that varieties of q-profiles and pressure profiles in the ITB can be achieved and controlled simultaneously. The simulations also showed that with the same RTC technique as used in JET experiments, it is possible to sustain the q-profiles and pressure profiles close to their set-point profiles for longer than the current diffusion time. In addition, the importance of being able to handle the multiple time scales to control the location and strength of the ITB is pointed out. Several future improvements and perspectives of the RTC scheme are presented.

  17. Proceedings of the 1986 workshop on advanced time-of-flight neutron powder diffraction

    SciTech Connect

    Lawson, A.C.; Smith, K.

    1986-09-01

    This report contains abstracts of talks and summaries of discussions from a small workshop held to discuss the future of time-of-flight neutron powder diffraction and its implementation at the Los Alamos Neutron Scattering Center. 47 refs., 3 figs.

  18. Recent advances in epigenomics in NSCLC: real-time detection and therapeutic implications.

    PubMed

    Di Paolo, Antonello; Del Re, Marzia; Petrini, Iacopo; Altavilla, Giuseppe; Danesi, Romano

    2016-08-01

    NSCLC is an aggressive disease with one of the poorer prognosis among cancers. The disappointing response to chemotherapy drives the search for genetic biomarkers aimed at both attaining an earlier diagnosis and choosing the most appropriate chemotherapy. In this scenario, epigenomic markers, such as DNA methylation, histone acetylation and the expression of noncoding RNAs, have been demonstrated to be reliable for the stratification of NSCLC patients. Newest techniques with increased sensitivity and the isolation of nucleic acids from plasma may allow an early diagnosis and then monitoring the efficacy over time. However, prospective confirmatory studies are still lacking. This article presents an overview of the epigenetic markers evaluated in NSCLC and discusses the role of their real-time detection in the clinical management of the disease.

  19. Advanced fibre reinforced thermoplastic composites with reduced processing times by use of nanoscale fillers

    NASA Astrophysics Data System (ADS)

    Brockerhoff, Georg; Brüll, Robert; Vonberg, Klaus; Seide, Gunnar; Gries, Thomas

    2016-07-01

    The industrial standard for the manufacturing of fibre reinforced thermoplastic composites (FRTCs) is the film stacking method. An alternative to this is commingling thermoplastic fibres with reinforcing fibres into hybrid rovings. These rovings are woven into weaves and consolidated through compression moulding. This paper evaluates the effects of 5 weight percent (wt.-%) titanium dioxide (TiO2) in commingled polyamide 6 (PA6) on the cycle time during the consolidation process and the mechanical properties. A product representing the industrial standard is used as reference. In order to achieve a good comparability with this product, the film stacking process is also reproduced. Finally, the three plate types are compared regarding their consolidation, tensile and flexural strength. The results show that the hybrid roving FRTC is more consolidated, has better mechanical properties and enables shorter cycle times when compared to the film stacking process.

  20. Real-Time Volumetric Phase Monitoring: Advancing Chemical Analysis by Countercurrent Separation.

    PubMed

    Pauli, Guido F; Pro, Samuel M; Chadwick, Lucas R; Burdick, Thomas; Pro, Luke; Friedl, Warren; Novak, Nick; Maltby, John; Qiu, Feng; Friesen, J Brent

    2015-07-21

    Countercurrent separation (CCS) utilizes the differential partitioning behavior of analytes between two immiscible liquid phases. We introduce the first platform ("CherryOne") capable of real-time monitoring, metering, and control of the dynamic liquid-liquid CCS process. Automated phase monitoring and volumetrics are made possible with an array of sensors, including the new permittivity-based phase metering apparatus (PMA). Volumetric data for each liquid phase are converted into a dynamic real-time display of stationary phase retention (Sf) and eluent partition coefficients (K), which represent critical parameters of CCS reproducibility. When coupled with the elution-extrusion operational mode (EECCC), automated Sf and K determination empowers untargeted and targeted applications ranging from metabolomic analysis to preparative purifications.

  1. Time-resolved X-ray scattering program at the Advanced Photon Source

    SciTech Connect

    Rodricks, B.

    1994-08-01

    The Time-Resolved Scattering Program`s goal is the development of instruments and techniques for time-resolved studies. This entails the development of wide bandpass and focusing optics, high-speed detectors, mechanical choppers, and components for the measurement and creation of changes in samples. Techniques being developed are pump-probe experiments, single-bunch scattering experiments, high-speed white and pink beam Laue scattering, and nanosecond to microsecond synchronization of instruments. This program will be carried out primarily from a white-beam, bend-magnet source, experimental station, 1-BM-B, that immediately follows the first optics enclosure (1-BM-A). This paper will describe the experimental station and instruments under development to carry out the program.

  2. Parallel processing of real-time dynamic systems simulation on OSCAR (Optimally SCheduled Advanced multiprocessoR)

    NASA Technical Reports Server (NTRS)

    Kasahara, Hironori; Honda, Hiroki; Narita, Seinosuke

    1989-01-01

    Parallel processing of real-time dynamic systems simulation on a multiprocessor system named OSCAR is presented. In the simulation of dynamic systems, generally, the same calculation are repeated every time step. However, we cannot apply to Do-all or the Do-across techniques for parallel processing of the simulation since there exist data dependencies from the end of an iteration to the beginning of the next iteration and furthermore data-input and data-output are required every sampling time period. Therefore, parallelism inside the calculation required for a single time step, or a large basic block which consists of arithmetic assignment statements, must be used. In the proposed method, near fine grain tasks, each of which consists of one or more floating point operations, are generated to extract the parallelism from the calculation and assigned to processors by using optimal static scheduling at compile time in order to reduce large run time overhead caused by the use of near fine grain tasks. The practicality of the scheme is demonstrated on OSCAR (Optimally SCheduled Advanced multiprocessoR) which has been developed to extract advantageous features of static scheduling algorithms to the maximum extent.

  3. Construction of a Direct Water-Injected Two-Stroke Engine for Phased Direct Fuel Injection-High Pressure Charging Investigations

    NASA Technical Reports Server (NTRS)

    Somsel, James P.

    1998-01-01

    The development of a water injected Orbital Combustion Process (OCP) engine was conducted to assess the viability of using the powerplant for high altitude NASA aircraft and General Aviation (GA) applications. An OCP direct fuel injected, 1.2 liter, three cylinder, two-stroke engine has been enhanced to independently inject water directly into the combustion chamber. The engine currently demonstrates low brake specific fuel consumption capability and an excellent power to weight ratio. With direct water injection, significant improvements can be made to engine power, to knock limits/ignition advance timing, and to engine NO(x) emissions. The principal aim of the testing was to validate a cyclic model developed by the Systems Analysis Branch at NASA Ames Research Center. The work is a continuation of Ames' investigations into a Phased Direct Fuel Injection Engine with High Pressure Charging (PDFI-ITPC).

  4. Improvement of electrical resistivity tomography for leachate injection monitoring

    SciTech Connect

    Clement, R.; Descloitres, M.; Guenther, T.; Oxarango, L.; Morra, C.

    2010-03-15

    Leachate recirculation is a key process in the scope of operating municipal waste landfills as bioreactors, which aims to increase the moisture content to optimize the biodegradation in landfills. Given that liquid flows exhibit a complex behaviour in very heterogeneous porous media, in situ monitoring methods are required. Surface time-lapse electrical resistivity tomography (ERT) is usually proposed. Using numerical modelling with typical 2D and 3D injection plume patterns and 2D and 3D inversion codes, we show that wrong changes of resistivity can be calculated at depth if standard parameters are used for time-lapse ERT inversion. Major artefacts typically exhibit significant increases of resistivity (more than +30%) which can be misinterpreted as gas migration within the waste. In order to eliminate these artefacts, we tested an advanced time-lapse ERT procedure that includes (i) two advanced inversion tools and (ii) two alternative array geometries. The first advanced tool uses invariant regions in the model. The second advanced tool uses an inversion with a 'minimum length' constraint. The alternative arrays focus on (i) a pole-dipole array (2D case), and (ii) a star array (3D case). The results show that these two advanced inversion tools and the two alternative arrays remove almost completely the artefacts within +/-5% both for 2D and 3D situations. As a field application, time-lapse ERT is applied using the star array during a 3D leachate injection in a non-hazardous municipal waste landfill. To evaluate the robustness of the two advanced tools, a synthetic model including both true decrease and increase of resistivity is built. The advanced time-lapse ERT procedure eliminates unwanted artefacts, while keeping a satisfactory image of true resistivity variations. This study demonstrates that significant and robust improvements can be obtained for time-lapse ERT monitoring of leachate recirculation in waste landfills.

  5. Timing of autumn bird migration under climate change: advances in long-distance migrants, delays in short-distance migrants

    USGS Publications Warehouse

    Jenni, L.; Kery, M.

    2003-01-01

    As a response to increasing spring temperature in temperate regions in recent years, populations of many plant and animal species, including migratory birds, have advanced the seasonal start of their reproduction or growth. However, the effects of climate changes on subsequent events of the annual cycle remain poorly understood. We investigated long-term changes in the timing of autumn migration in birds, a key event in the annual cycle limiting the reproductive period. Using data spanning a 42-year period, we analysed long-term changes in the passage of 65 species of migratory birds through Western Europe. The autumn passage of migrants wintering south of the Sahara has advanced in recent years, presumably as a result of selection pressure to cross the Sahel before its seasonal dry period. In contrast, migrants wintering north of the Sahara have delayed autumn passage. In addition, species with a variable rather than a fixed number of broods per year have delayed passage, possibly because they are free to attempt more broods. Recent climate changes seem to have a simple unidirectional effect on the seasonal onset of reproduction, but complex and opposing effects on the timing of subsequent events in the annual cycle, depending on the ecology and life history of a species. This complicates predictions of overall effects of global warming on avian communities.

  6. Timing of autumn bird migration under climate change: advances in long-distance migrants, delays in short-distance migrants.

    PubMed Central

    Jenni, Lukas; Kéry, Marc

    2003-01-01

    As a response to increasing spring temperature in temperate regions in recent years, populations of many plant and animal species, including migratory birds, have advanced the seasonal start of their reproduction or growth. However, the effects of climate changes on subsequent events of the annual cycle remain poorly understood. We investigated long-term changes in the timing of autumn migration in birds, a key event in the annual cycle limiting the reproductive period. Using data spanning a 42-year period, we analysed long-term changes in the passage of 65 species of migratory birds through Western Europe. The autumn passage of migrants wintering south of the Sahara has advanced in recent years, presumably as a result of selection pressure to cross the Sahel before its seasonal dry period. In contrast, migrants wintering north of the Sahara have delayed autumn passage. In addition, species with a variable rather than a fixed number of broods per year have delayed passage, possibly because they are free to attempt more broods. Recent climate changes seem to have a simple unidirectional effect on the seasonal onset of reproduction, but complex and opposing effects on the timing of subsequent events in the annual cycle, depending on the ecology and life history of a species. This complicates predictions of overall effects of global warming on avian communities. PMID:12965011

  7. Advanced Photon Counting Imaging Detectors with 100ps Timing for Astronomical and Space Sensing Applications

    NASA Astrophysics Data System (ADS)

    Siegmund, O.; Vallerga, J.; Welsh, B.; Rabin, M.; Bloch, J.

    In recent years EAG has implemented a variety of high-resolution, large format, photon-counting MCP detectors in space instrumentation for satellite FUSE, GALEX, IMAGE, SOHO, HST-COS, rocket, and shuttle payloads. Our scheme of choice has been delay line readouts encoding photon event position centroids, by determination of the difference in arrival time of the event charge at the two ends of a distributed resistive-capacitive (RC) delay line. Our most commonly used delay line configuration is the cross delay line (XDL). In its simplest form the delay-line encoding electronics consists of a fast amplifier for each end of the delay line, followed by time-to-digital converters (TDC's). We have achieved resolutions of < 25 μm in tests over 65 mm x 65 mm (3k x3k resolution elements) with excellent linearity. Using high speed TDC's, we have been able to encode event positions for random photon rates of ~1 MHz, while time tagging events using the MCP output signal to better than 100 ps. The unique ability to record photon X,Y,T high fidelity information has advantages over "frame driven" recording devices for some important applications. For example we have built open face and sealed tube cross delay line detectors used for biological fluorescence lifetime imaging, observation of flare stars, orbital satellites and space debris with the GALEX satellite, and time resolved imaging of the Crab Pulsar with a telescope as small as 1m. Although microchannel plate delay line detectors meet many of the imaging and timing demands of various applications, they have limitations. The relatively high gain (107) reduces lifetime and local counting rate, and the fixed delay (10's of ns) makes multiple simultaneous event recording problematic. To overcome these limitations we have begun development of cross strip readout anodes for microchannel plate detectors. The cross strip (XS) anode is a coarse (~0.5 mm) multi-layer metal and ceramic pattern of crossed fingers on an alumina

  8. Development of a real-time aeroperformance analysis technique for the X-29A advanced technology demonstrator

    NASA Technical Reports Server (NTRS)

    Ray, R. J.; Hicks, J. W.; Alexander, R. I.

    1988-01-01

    The X-29A advanced technology demonstrator has shown the practicality and advantages of the capability to compute and display, in real time, aeroperformance flight results. This capability includes the calculation of the in-flight measured drag polar, lift curve, and aircraft specific excess power. From these elements many other types of aeroperformance measurements can be computed and analyzed. The technique can be used to give an immediate postmaneuver assessment of data quality and maneuver technique, thus increasing the productivity of a flight program. A key element of this new method was the concurrent development of a real-time in-flight net thrust algorithm, based on the simplified gross thrust method. This net thrust algorithm allows for the direct calculation of total aircraft drag.

  9. Response times of children and adolescents with Asperger syndrome on an 'advanced' test of theory of mind.

    PubMed

    Kaland, Nils; Smith, Lars; Mortensen, Erik Lykke

    2007-02-01

    In the present study the response times of 10- to 20-year-old participants with Asperger syndrome (AS) (N=21) of normal intelligence and a control group of typically developing individuals (N=20) were recorded on a new 'advanced' test of theory of mind. This test taps the ability to make mental-state inferences versus physical-state inferences in a story context. The participants with AS were significantly slower than the controls on both tasks. In addition, the differences in response times between mental- and physical-state inference were significantly larger in the AS group than in the control group, suggesting that the clinical group experienced more problems than the controls in making inferences about mental states than about physical states.

  10. Development of a real-time aeroperformance analysis technique for the X-29A advanced technology demonstrator

    NASA Technical Reports Server (NTRS)

    Ray, R. J.; Hicks, J. W.; Alexander, R. I.

    1988-01-01

    The X-29A advanced technology demonstrator has shown the practicality and advantages of the capability to compute and display, in real time, aeroperformance flight results. This capability includes the calculation of the in flight measured drag polar, lift curve, and aircraft specific excess power. From these elements, many other types of aeroperformance measurements can be computed and analyzed. The technique can be used to give an immediate postmaneuver assessment of data quality and maneuver technique, thus increasing the productivity of a flight program. A key element of this new method was the concurrent development of a real-time in flight net thrust algorithm, based on the simplified gross thrust method. This net thrust algorithm allows for the direct calculation of total aircraft drag.

  11. A real-time simulation facility for advanced digital guidance and control system research

    NASA Technical Reports Server (NTRS)

    Bryant, W. H.; Downing, D. R.; Ostroff, A. J.

    1979-01-01

    A real-time simulation facility built at NASA's Langley Research Center to support digital guidance and control research and development activities is examined. The unit has recently been used to develop autoland systems for VTOL. The paper describes the autoland experiment and the flight environment, the simulation facility hardware and software, and presents typical simulation data to illustrate the type of data analysis carried out during software development. Finally, flight data for a later version of the autoland system are presented to demonstrate the simulation's capability to predict overall system behavior.

  12. Soil Contamination, Advanced integrated characterisation and time-lapse Monitoring, SoilCAM project highlights

    NASA Astrophysics Data System (ADS)

    French, H. K.; Van Der Zee, S. E.; Wehrer, M.; Godio, A.; Pedersen, L. B.; Tsocano, G.

    2013-12-01

    The SoilCAM project (2008- 2012, EU-FP7-212663) aimed at improving methods for monitoring subsurace contaminant distribution and biodegradation. Two test sites were chosen, Oslo airport Gardermoen, Norway where de-icing agents infiltrate the soil during snowmelt and the Trecate site in Italy where an inland crude oil spill occurred in 1994. A number of geophysical investigation techniques were combined with soil and water sampling techniques. Data obtained from time-lapse measurements were further analysed by numerical modelling of flow and transport at different scales in order to characterise transport processes in the unsaturated and saturated zones. Laboratory experiments provided physical and biogeochemical data for model parameterisation and to select remediation methods. The geophysical techniques were used to map geological heterogeneities and to conduct time-lapse measurements of processes in the unsaturated zone. Both cross borehole and surface electrodes were used for electrical resistivity and induced polarisation surveys. Results showed clear indications of areas highly affected by de-icing chemicals along the runway at Oslo airport. The time lapse measurements along the runway at the airport showed infiltration patterns during snowmelt and were used to validate 2D unsaturated flow and transport simulations using SUTRA. The simulations illustrate the effect of layering geological structures and membranes, buried parallel to the runway, on the flow pattern. Complex interaction between bio-geo-chemical processes in a 1D vertical profile along the runway were described with the ORCHESTRA model. Smaller scale field site measurements revealed increase of iron and manganese during degradation of de-icing chemicals. At the Trecate site a combination of georadar, electrical resistivity and radio magneto telluric provided a broad outline of the geology down to 50 m. Anomalies in the Induced polarisation and electrical resistivity data from the cross borehole

  13. Advanced imaging to extend the therapeutic time window of acute ischemic stroke.

    PubMed

    Fisher, Marc; Albers, Gregory W

    2013-01-01

    Reperfusion therapy for acute stroke has evolved from the initial use of intravenous tissue plasminogen activator (tPA) within 3 hours of symptom onset to more recent guideline-recommended use up to 4.5 hours. In addition, endovascular therapy is increasingly utilized for stroke treatment and is typically initiated up to 8 hours after onset. Recent studies demonstrate that imaging of the ischemic penumbra with diffusion/perfusion magnetic resonance imaging (MRI) can identify subgroups of patients who are likely to improve following successful reperfusion (Target Mismatch profile) and others who are at increased risk for hemorrhage and poor clinical outcomes (Malignant profile). New data indicate that stent retriever devices provide better recanalization efficacy and clinical outcomes than the previously available mechanical thrombectomy devices. Going forward, we believe that the use of penumbral imaging with validated MRI techniques, as well as the currently less well-validated computed tomography (CT) perfusion approach, will maximize benefit and reduce the risk of adverse events and poor outcomes when used both early after stroke onset and at later time points. New trials that feature diffusion/perfusion MRI or CT perfusion-based patient selection for treatment with intravenous tPA and or endovascular therapies versus nonreperfused control groups are planned or in progress. We predict that these trials will confirm the hypothesis that penumbral imaging can enhance patient selection and extend the therapeutic time window for acute ischemic stroke.

  14. Trends and advances in food analysis by real-time polymerase chain reaction.

    PubMed

    Salihah, Nur Thaqifah; Hossain, Mohammad Mosharraf; Lubis, Hamadah; Ahmed, Minhaz Uddin

    2016-05-01

    Analyses to ensure food safety and quality are more relevant now because of rapid changes in the quantity, diversity and mobility of food. Food-contamination must be determined to maintain health and up-hold laws, as well as for ethical and cultural concerns. Real-time polymerase chain reaction (RT-PCR), a rapid and inexpensive quantitative method to detect the presence of targeted DNA-segments in samples, helps in determining both accidental and intentional adulterations of foods by biological contaminants. This review presents recent developments in theory, techniques, and applications of RT-PCR in food analyses, RT-PCR addresses the limitations of traditional food analyses in terms of sensitivity, range of analytes, multiplexing ability, cost, time, and point-of-care applications. A range of targets, including species of plants or animals which are used as food ingredients, food-borne bacteria or viruses, genetically modified organisms, and allergens, even in highly processed foods can be identified by RT-PCR, even at very low concentrations. Microfluidic RT-PCR eliminates the separate sample-processing step to create opportunities for point-of-care analyses. We also cover the challenges related to using RT-PCR for food analyses, such as the need to further improve sample handling.

  15. Advances in Digital Calibration Techniques Enabling Real-Time Beamforming SweepSAR Architectures

    NASA Technical Reports Server (NTRS)

    Hoffman, James P.; Perkovic, Dragana; Ghaemi, Hirad; Horst, Stephen; Shaffer, Scott; Veilleux, Louise

    2013-01-01

    Real-time digital beamforming, combined with lightweight, large aperture reflectors, enable SweepSAR architectures, which promise significant increases in instrument capability for solid earth and biomass remote sensing. These new instrument concepts require new methods for calibrating the multiple channels, which are combined on-board, in real-time. The benefit of this effort is that it enables a new class of lightweight radar architecture, Digital Beamforming with SweepSAR, providing significantly larger swath coverage than conventional SAR architectures for reduced mass and cost. This paper will review the on-going development of the digital calibration architecture for digital beamforming radar instrument, such as the proposed Earth Radar Mission's DESDynI (Deformation, Ecosystem Structure, and Dynamics of Ice) instrument. This proposed instrument's baseline design employs SweepSAR digital beamforming and requires digital calibration. We will review the overall concepts and status of the system architecture, algorithm development, and the digital calibration testbed currently being developed. We will present results from a preliminary hardware demonstration. We will also discuss the challenges and opportunities specific to this novel architecture.

  16. High-pressure fuel injection system for diesel engine

    SciTech Connect

    Hoshi, Y.

    1986-01-21

    This patent describes a high-pressure fuel injection system for a diesel engine. This system consists of: (a) main pumps for injecting fuel each located at one of cylinders of the engine and formed with a fuel injecting port, a discharge valve located in a path connecting the first injected fuel space with the fuel injecting port. The discharge valve is opened when the fuel to be injected reaches a predetermined pressure level. A first injection timing fuel space fluidly connected with the first injected fuel space through a movable shuttle is filled with injection timing fuel, and a plunger varies the volume of the first injection timing fuel space; (b) a metering and distributing pump formed with injection fuel outputs and injection timing fuel outlets corresponding in number to the cylinders of the engine for discharging fuel in timed relation to the rotation of the engine; (c) fuel metering valves for metering fuel flowing into the second injected fuel space and second injection timing fuel space respectively; (d) pipes for fluidly connecting the first injected fuel space and first injection timing fuel space of the main pump for injecting fuel with the injected fuel outlets and injection timing fuel outlets of the metering and distributing pump respectively; and (e) a rocker arm mechanism for driving the plunger of the main pump for injecting fuel in timed relation to the rotation of the engine.

  17. Is Advanced Real-Time Energy Metering Sufficient to Persuade People to Save Energy?

    NASA Astrophysics Data System (ADS)

    Ting, L.; Leite, H.; Ponce de Leão, T.

    2012-10-01

    In order to promote a low-carbon economy, EU citizens may soon be able to check their electricity consumption from smart meter. It is hoped that smart meter can, by providing real-time consumption and pricing information to residential users, help reducing demand for electricity. It is argued in this paper that, according the Elaborative Likelihood Model (ELM), these methods are most likely to be effective when consumers perceive the issue of energy conservation relevant to their lives. Nevertheless, some fundamental characteristics of these methods result in limited amount of perceived personal relevance; for instance, energy expenditure expense may be relatively small comparing to other household expenditure like mortgage and consumption information does not enhance interpersonal trust. In this paper, it is suggested that smart meter can apply the "nudge" approaches which respond to ELM as the use of simple rules to make decision, which include the change of feedback delivery and device design.

  18. Advancing Navigation, Timing, and Science with the Deep Space Atomic Clock

    NASA Technical Reports Server (NTRS)

    Ely, Todd A.; Seubert, Jill; Bell, Julia

    2014-01-01

    NASA's Deep Space Atomic Clock mission is developing a small, highly stable mercury ion atomic clock with an Allan deviation of at most 1e-14 at one day, and with current estimates near 3e-15. This stability enables one-way radiometric tracking data with accuracy equivalent to and, in certain conditions, better than current two-way deep space tracking data; allowing a shift to a more efficient and flexible one-way deep space navigation architecture. DSAC-enabled one-way tracking will benefit navigation and radio science by increasing the quantity and quality of tracking data. Additionally, DSAC would be a key component to fully-autonomous onboard radio navigation useful for time-sensitive situations. Potential deep space applications of DSAC are presented, including orbit determination of a Mars orbiter and gravity science on a Europa flyby mission.

  19. Dynamics in Transcriptomics: Advancements in RNA-seq Time Course and Downstream Analysis

    PubMed Central

    Spies, Daniel; Ciaudo, Constance

    2015-01-01

    Analysis of gene expression has contributed to a plethora of biological and medical research studies. Microarrays have been intensively used for the profiling of gene expression during diverse developmental processes, treatments and diseases. New massively parallel sequencing methods, often named as RNA-sequencing (RNA-seq) are extensively improving our understanding of gene regulation and signaling networks. Computational methods developed originally for microarrays analysis can now be optimized and applied to genome-wide studies in order to have access to a better comprehension of the whole transcriptome. This review addresses current challenges on RNA-seq analysis and specifically focuses on new bioinformatics tools developed for time series experiments. Furthermore, possible improvements in analysis, data integration as well as future applications of differential expression analysis are discussed. PMID:26430493

  20. Novel Advancements in Internet-Based Real-Time Data Technologies

    NASA Technical Reports Server (NTRS)

    Myers, Gerry; Welch, Clara L. (Technical Monitor)

    2002-01-01

    AZ Technology has been working with NASA MSFC (Marshall Space Flight Center) to find ways to make it easier for remote experimenters (RPI's) to monitor their International Space Station (ISS) payloads in real-time from anywhere using standard/familiar devices. That effort resulted in a product called 'EZStream' which is in use on several ISS-related projects. Although the initial implementation is geared toward ISS, the architecture and lessons learned are applicable to other space-related programs. This paper begins with a brief history on why Internet-based real-time data is important and where EZStream or products like it fit in the flow of data from orbit to experimenter/researcher. A high-level architecture is then presented along with explanations of the components used. A combination of commercial-off-the-shelf (COTS), Open Source, and custom components are discussed. The use of standard protocols is shown along with some details on how data flows between server and client. Some examples are presented to illustrate how a system like EZStream can be used in real world applications and how care was taken to make the end-user experience as painless as possible. A system such as EZStream has potential in the commercial (non-ISS) arena and some possibilities are presented. During the development and fielding of EZStream, a lot was learned. Good and not so good decisions were made. Some of the major lessons learned will be shared. The development of EZStream is continuing and the future of EZStream will be discussed to shed some light over the technological horizon.

  1. Litter decomposition over broad spatial and long time scales investigated by advanced solid-state NMR: insight into effects of climate, litter quality, and time

    NASA Astrophysics Data System (ADS)

    Mao, J.; Chen, N.; Harmon, M. E.; Li, Y.; Cao, X.; Chappell, M.

    2012-12-01

    Advanced 13C solid-state NMR techniques were employed to study the chemical structural changes of litter decomposition across broad spatial and long time scales. The fresh and decomposed litter samples of four species (Acer saccharum (ACSA), Drypetes glauca (DRGL), Pinus resinosa (PIRE), and Thuja plicata (THPL)) incubated for up to 10 years at four sites under different climatic conditions (from Arctic to tropical forest) were examined. Decomposition generally led to an enrichment of cutin and surface wax materials, and a depletion of carbohydrates causing overall composition to become more similar compared with original litters. However, the changes of main constituents in the four litters were inconsistent with the four litters following different pathways of decomposition at the same site. As decomposition proceeded, waxy materials decreased at the early stage and then gradually increased in PIRE; DRGL showed a significant depletion of lignin and tannin while the changes of lignin and tannin were relative small and inconsistent for ACSA and THPL. In addition, the NCH groups, which could be associated with either fungal cell wall chitin or bacterial wall petidoglycan, were enriched in all litters except THPL. Contrary to the classic lignin-enrichment hypothesis, DRGL with low-quality C substrate had the highest degree of composition changes. Furthermore, some samples had more "advanced" compositional changes in the intermediate stage of decomposition than in the highly-decomposed stage. This pattern might be attributed to the formation of new cross-linking structures, that rendered substrates more complex and difficult for enzymes to attack. Finally, litter quality overrode climate and time factors as a control of long-term changes of chemical composition.

  2. Evaluation of an Advanced-Practice Physical Therapist in a Specialty Shoulder Clinic: Diagnostic Agreement and Effect on Wait Times

    PubMed Central

    Robarts, Susan; Kennedy, Deborah; McKnight, Cheryl; MacLeod, Anne Marie; Holtby, Richard

    2013-01-01

    ABSTRACT Purpose: To examine the role of an advanced-practice physiotherapist (APP) with respect to (1) agreement with an orthopaedic surgeon on diagnosis and management of patients with shoulder problems; (2) wait times; and (3) satisfaction with care. Methods: This prospective study involved patients with shoulder complaints who were referred to a shoulder specialist in a tertiary care centre. Agreement was examined on seven major diagnostic categories, need for further examination and surgery, and type of surgical procedure. Wait times were compared between the APP- and surgeon-led clinics from referral date to date of initial consultation, date of final diagnostic test, and date of confirmed diagnosis and planned treatment. A modified and validated version of the Visit-Specific Satisfaction Instrument assessed satisfaction in seven domains. Kappa (κ) coefficients and bias- and prevalence-adjusted kappa (PABAK) values were calculated, and strength of agreement was categorized. Wait time and satisfaction data were examined using non-parametric statistics. Results: Agreement on major diagnostic categories varied from 0.68 (good) to 0.96 (excellent). Agreement with respect to indication for surgery was κ=0.75, p<0.001; 95% CI, 0.62–0.88 (good). Wait time for APP assessment was significantly shorter than wait time for surgeon consultation at all time points (p<0.001); the surgeon's wait time was significantly reduced over 3 years. High satisfaction was reported in all components of care received from both health care providers. Conclusions: Using experienced physiotherapists in an extended role reduces wait times without compromising patient clinical management and overall satisfaction. PMID:24381382

  3. Leakage current conduction, hole injection, and time-dependent dielectric breakdown of n-4H-SiC MOS capacitors during positive bias temperature stress

    NASA Astrophysics Data System (ADS)

    Samanta, Piyas; Mandal, Krishna C.

    2017-01-01

    The conduction mechanism(s) of gate leakage current JG through thermally grown silicon dioxide (SiO2) films on the silicon (Si) face of n-type 4H-silicon carbide (4H-SiC) has been studied in detail under positive gate bias. It was observed that at an oxide field above 5 MV/cm, the leakage current measured up to 303 °C can be explained by Fowler-Nordheim (FN) tunneling of electrons from the accumulated n-4H-SiC and Poole-Frenkel (PF) emission of trapped electrons from the localized neutral traps located at ≈2.5 eV below the SiO2 conduction band. However, the PF emission current IPF dominates the FN electron tunneling current IFN at oxide electric fields Eox between 5 and 10 MV/cm and in the temperature ranging from 31 to 303 °C. In addition, we have presented a comprehensive analysis of injection of holes and their subsequent trapping into as-grown oxide traps eventually leading to time-dependent dielectric breakdown during electron injection under positive bias temperature stress (PBTS) in n-4H-SiC metal-oxide-silicon carbide structures. Holes were generated in the heavily doped n-type polycrystalline silicon (n+-polySi) gate (anode) as well as in the oxide bulk via band-to-band ionization by the hot-electrons depending on their energy and SiO2 film thickness at Eox between 6 and 10 MV/cm (prior to the intrinsic oxide breakdown field). Transport of hot electrons emitted via both FN and PF mechanisms was taken into account. On the premise of the hole-induced oxide breakdown model, the time- and charge-to-breakdown ( tBD and QBD ) of 8.5 to 47 nm-thick SiO2 films on n-4H-SiC were estimated at a wide range of temperatures. tBD follows the Arrhenius law with activation energies varying inversely with initial applied constant field Eox supporting the reciprocal field ( 1 /E ) model of breakdown irrespective of SiO2 film thicknesses. We obtained an excellent margin (6.66 to 6.33 MV/cm at 31 °C and 5.11 to 4.55 MV/cm at 303 °C) of normal operating field for a 10

  4. Fuel injection pump

    SciTech Connect

    Luscomb, D.A.

    1984-05-22

    A fuel injection pump including a plunger and a piston movably disposed in a pumping chamber, means for initiating fuel injection and means for terminating fuel injection, the plunger periodically pressurizing fuel in a pressure chamber and the piston spaced from the plunger and allowing a metering chamber to fill with a metered quantity of fuel to be injected to an engine. The means for initiating injection comprises a pilot valve having a solenoid to selectively operate between either of two states and a control valve movable between first and second positions in response to the state of pilot valve, the first position filling the metering chamber with the metered quantity of fuel. The pilot valve determines the fuel quantity to be delivered to the engine relative to a signal from an electronic controller. An accumulator is pressurized during each cycle of the plunger to provide pressurized fuel during a metering phase. A variable orifice adjusts the rate of flow during the time fuel is being metered to metering chamber.

  5. Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry

    PubMed Central

    Sakane, Chiharu; Ohta, Hiromichi; Shidoji, Yoshihiro

    2015-01-01

    Lysine-specific demethylase 1 (LSD1/KDM1A), a histone-modifying enzyme, is upregulated in many cancers, especially in neuroblastoma, breast cancer and hepatoma. We have established a simple method to measure LSD1 activity using a synthetic N-terminal 21-mer peptide of histone H3, which is dimethylated at Lys-4 (H3K4me2). After the enzyme reaction, a substrate of H3K4me2 and two demethylated products, H3K4me1 and H3K4me0, were quantitatively determined by flow injection time-of-flight mass spectrometry (FI-TOF/MS). By using recombinant human LSD1, a nonlinear fitting simulation of the data obtained by FI-TOF/MS produced typical consecutive-reaction kinetics. Apparent Km and kcat values of hLSD1 for the first and second demethylation reactions were found to be in the range of reported values. Tranylcypromine was shown to inhibit LSD1 activity with an IC50 of 6.9 µM for the first demethylation reaction and 5.8 µM for the second demethylation reaction. The FI-TOF/MS assay revealed that the endogenous LSD1 activity was higher in the nuclear extracts of SH-SY5Y cells than in HeLa or PC-3 cells, and this is in accordance with the immunoblotting data using an anti-LSD1 antibody. A simple, straightforward FI-TOF/MS assay is described to efficiently measure LSD1 activity in the nuclear extracts of cultured cells. PMID:25759518

  6. Design and implementation of a CO{sub 2} flood utilizing advanced reservoir characterization and horizontal injection wells in a shallow shelf carbonate approaching waterflood depletion. Annual Report, July 1, 1995--June 30, 1996

    SciTech Connect

    Chimahusky, J.S.; Hallenbeck, L.D.; Harpole, K.J.; Dollens, K.B.

    1997-05-01

    The work reported herein covers select tasks remaining in Budget Phase I and many of the tasks of Budget Phase II. The principal Tasks in Budget Phase I included in this report are Reservoir Analysis and Characterization; Advanced Technical Studies; and Technology Transfer, Reporting and Project Management Activities for Budget Phase I. The principle Task in Budget Phase II included in this report is Field Demonstration. Completion of these tasks has enabled an optimum carbon dioxide (CO{sub 2}) flood project to be designed, economically evaluated, and implemented in the field. Field implementation of the project commenced during late 1995, with actual CO{sub 2} injection scheduled for start-up in mid-July, 1996. The current project has focused on reducing initial investment cost by utilizing horizontal injection wells and concentrating the project in the best productivity area of the field. An innovative CO{sub 2} purchase agreement (no take-or-pay provisions, CO{sub 2} purchase price tied to West Texas Intermediate (WTI) crude oil price) and gas recycle agreements (expensing costs as opposed to a large upfront capital investment for compression) were negotiated to further improve the project economics. The Grayburg-San Andres section had previously been divided into multiple zones based on the core study and gamma ray markers that correlate wells within the Unit. Each zone was mapped as continuous across the field. Previous core studies concluded that the reservoir quality in the South Cowden Unit (SCU) is controlled primarily by the distribution of a bioturbated and diagenetically-altered rock type with a distinctive {open_quotes}chaotic{close_quotes} texture. The {open_quotes}chaotic{close_quotes} modifier is derived from the visual effect of pervasive, small-scale intermixing of tan oil-stained reservoir rock with tight gray non-reservoir rock.

  7. Advanced image processing and wavefront sensing with real-time phase diversity.

    PubMed

    Dolne, Jean J; Menicucci, Paul; Miccolis, David; Widen, Ken; Seiden, Harold; Vachss, Frederick; Schall, Harold

    2009-01-01

    This paper will describe a state-of-the-art approach to real-time wavefront sensing and image enhancement. It will explore Boeing's existing technology to realize a 50 Hz frame rate (with a path to 1 KHz and higher). At this higher rate, phase diversity will be readily applicable to compensate for distortions of large dynamic bandwidth such as those of the atmosphere. We will describe various challenges in aligning a two-camera phase diversity system. Such configurations make it almost impossible to process the captured images without additional upgrade in the algorithm to account for alignment errors. An example of an error is the relative misalignment of the two images, the "best-focus" and the diversity image, where it is extremely hard to maintain alignment to less than a fraction of 1 pixel. We will show that the algorithm performance increases dramatically when we account for these errors in the estimation process. Preliminary evaluation has assessed a National Imagery Interpretability Rating Scale increase of approximately 3 from the best-focus to the enhanced image. Such a performance improvement would greatly increase the operating range (or, equivalently, decrease the weight) of many optical systems.

  8. Real-time approximate optimal guidance laws for the advanced launch system

    NASA Technical Reports Server (NTRS)

    Speyer, Jason L.; Feeley, Timothy; Hull, David G.

    1989-01-01

    An approach to optimal ascent guidance for a launch vehicle is developed using an expansion technique. The problem is to maximize the payload put into orbit subject to the equations of motion of a rocket over a rotating spherical earth. It is assumed that the thrust and gravitational forces dominate over the aerodynamic forces. It is shown that these forces can be separated by a small parameter epsilon, where epsilon is the ratio of the atmospheric scale height to the radius of the earth. The Hamilton-Jacobi-Bellman or dynamic programming equation is expanded in a series where the zeroth-order term (epsilon = 0) can be obtained in closed form. The zeroth-order problem is that of putting maximum payload into orbit subject to the equations of motion of a rocket in a vacuum over a flat earth. The neglected inertial and aerodynamic terms are included in higher order terms of the expansion, which are determined from the solution of first-order linear partial differential equations requiring only quadrature integrations. These quadrature integrations can be performed rapidly, so that real-time approximate optimization can be used to construct the launch guidance law.

  9. Advanced characterisation of encapsulated lipid powders regarding microstructure by time domain-nuclear magnetic resonance.

    PubMed

    Linke, Annika; Anzmann, Theresa; Weiss, Jochen; Kohlus, Reinhard

    2017-03-15

    Encapsulation is an established technique to protect sensitive materials from environmental stress. In order to understand the physical protection mechanism against oxidation, knowledge about the powder microstructure is required. Time domain-nuclear magnetic resonance (TD-NMR) has the potential to determine the surface oil (SO) and droplet size distribution by relaxation and restricted self-diffusion, respectively. The amount of SO, the retention and encapsulation efficiency are determined based on a lipid balance. The oil load of the initial powder and after SO removal is measured by TD-NMR. The results correlate with gravimetric and photometric references. The oil droplet size obtained by TD-NMR correlates well with static light scattering. The diameter of droplets in emulsions and dried powder both measured by TD-NMR, correlates (r = 0.998), implying that oil droplets embedded in a solid matrix can be measured. Summarising, TD-NMR allows analysis of the microstructure of encapsulated lipid powders, in a rapid, simple and non-destructive way.

  10. Modern U-Pb chronometry of meteorites: advancing to higher time resolution reveals new problems

    USGS Publications Warehouse

    Amelin, Y.; Connelly, J.; Zartman, R.E.; Chen, J.-H.; Gopel, C.; Neymark, L.A.

    2009-01-01

    In this paper, we evaluate the factors that influence the accuracy of lead (Pb)-isotopic ages of meteorites, and may possibly be responsible for inconsistencies between Pb-isotopic and extinct nuclide timescales of the early Solar System: instrumental mass fractionation and other possible analytical sources of error, presence of more than one component of non-radiogenic Pb, migration of ancient radiogenic Pb by diffusion and other mechanisms, possible heterogeneity of the isotopic composition of uranium (U), uncertainties in the decay constants of uranium isotopes, possible presence of "freshly synthesized" actinides with short half-life (e.g. 234U) in the early Solar System, possible initial disequilibrium in the uranium decay chains, and potential fractionation of radiogenic Pb isotopes and U isotopes caused by alpha-recoil and subsequent laboratory treatment. We review the use of 232Th/238U values to assist in making accurate interpretations of the U-Pb ages of meteorite components. We discuss recently published U-Pb dates of calcium-aluminum-rich inclusions (CAIs), and their apparent disagreement with the extinct nuclide dates, in the context of capability and common pitfalls in modern meteorite chronology. Finally, we discuss the requirements of meteorites that are intended to be used as the reference points in building a consistent time scale of the early Solar System, based on the combined use of the U-Pb system and extinct nuclide chronometers.

  11. Advanced SuperDARN meteor wind observations based on raw time series analysis technique

    NASA Astrophysics Data System (ADS)

    Tsutsumi, M.; Yukimatu, A. S.; Holdsworth, D. A.; Lester, M.

    2009-04-01

    The meteor observation technique based on SuperDARN raw time series analysis has been upgraded. This technique extracts meteor information as biproducts and does not degrade the quality of normal SuperDARN operations. In the upgrade the radar operating system (RADOPS) has been modified so that it can oversample every 15 km during the normal operations, which have a range resolution of 45 km. As an alternative method for better range determination a frequency domain interferometry (FDI) capability was also coded in RADOPS, where the operating radio frequency can be changed every pulse sequence. Test observations were conducted using the CUTLASS Iceland East and Finland radars, where oversampling and FDI operation (two frequencies separated by 3 kHz) were simultaneously carried out. Meteor ranges obtained in both ranging techniques agreed very well. The ranges were then combined with the interferometer data to estimate meteor echo reflection heights. Although there were still some ambiguities in the arrival angles of echoes because of the rather long antenna spacing of the interferometers, the heights and arrival angles of most of meteor echoes were more accurately determined than previously. Wind velocities were successfully estimated over the height range of 84 to 110 km. The FDI technique developed here can be further applied to the common SuperDARN operation, and study of fine horizontal structures of F region plasma irregularities is expected in the future.

  12. The cost of unsafe injections.

    PubMed Central

    Miller, M. A.; Pisani, E.

    1999-01-01

    Unsafe injection practices are associated with substantial morbidity and mortality, particularly from hepatitis B and C and human immunodeficiency virus (HIV) infections. These inadvertently transmitted bloodborne diseases become manifest some considerable time after infection and hence may not be appropriately accounted for. Annually more than 1.3 million deaths and US$ 535 million are estimated to be due to current unsafe injection practices. With the global increase in the number of injections for vaccination and medical services, safer injecting technologies such as auto-disable syringes must be budgeted for. Investment in health education and safer disposal will also reduce infections associated with unsafe injecting practices. Safer injecting practices are more expensive than current less safe practices, but the additional cost is more than offset by the reduction in disease that would result. PMID:10593028

  13. Advanced time and wavelength division multiplexing for metropolitan area optical data communication networks

    NASA Astrophysics Data System (ADS)

    Watford, M.; DeCusatis, C.

    2005-09-01

    With the advent of new regulations governing the protection and recovery of sensitive business data, including the Sarbanes-Oxley Act, there has been a renewed interest in business continuity and disaster recovery applications for metropolitan area networks. Specifically, there has been a need for more efficient bandwidth utilization and lower cost per channel to facilitate mirroring of multi-terabit data bases. These applications have further blurred the boundary between metropolitan and wide area networks, with synchronous disaster recovery applications running up to 100 km and asynchronous solutions extending to 300 km or more. In this paper, we discuss recent enhancements in the Nortel Optical Metro 5200 Dense Wavelength Division Multiplexing (DWDM) platform, including features recently qualified for data communication applications such as Metro Mirror, Global Mirror, and Geographically Distributed Parallel Sysplex (GDPS). Using a 10 Gigabit/second (Gbit/s) backbone, this solution transports significantly more Fibre Channel protocol traffic with up to five times greater hardware density in the same physical package. This is also among the first platforms to utilize forward error correction (FEC) on the aggregate signals to improve bit error rate (BER) performance beyond industry standards. When combined with encapsulation into wide area network protocols, the use of FEC can compensate for impairments in BER across a service provider infrastructure without impacting application level performance. Design and implementation of these features will be discussed, including results from experimental test beds which validate these solutions for a number of applications. Future extensions of this environment will also be considered, including ways to provide configurable bandwidth on demand, mitigate Fibre Channel buffer credit management issues, and support for other GDPS protocols.

  14. Computer architecture for efficient algorithmic executions in real-time systems: New technology for avionics systems and advanced space vehicles

    NASA Technical Reports Server (NTRS)

    Carroll, Chester C.; Youngblood, John N.; Saha, Aindam

    1987-01-01

    Improvements and advances in the development of computer architecture now provide innovative technology for the recasting of traditional sequential solutions into high-performance, low-cost, parallel system to increase system performance. Research conducted in development of specialized computer architecture for the algorithmic execution of an avionics system, guidance and control problem in real time is described. A comprehensive treatment of both the hardware and software structures of a customized computer which performs real-time computation of guidance commands with updated estimates of target motion and time-to-go is presented. An optimal, real-time allocation algorithm was developed which maps the algorithmic tasks onto the processing elements. This allocation is based on the critical path analysis. The final stage is the design and development of the hardware structures suitable for the efficient execution of the allocated task graph. The processing element is designed for rapid execution of the allocated tasks. Fault tolerance is a key feature of the overall architecture. Parallel numerical integration techniques, tasks definitions, and allocation algorithms are discussed. The parallel implementation is analytically verified and the experimental results are presented. The design of the data-driven computer architecture, customized for the execution of the particular algorithm, is discussed.

  15. Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections.

    PubMed

    Hoeger-Bement, Marie K; Sluka, Kathleen A

    2003-07-02

    Spinal activation of the cAMP pathway produces mechanical hyperalgesia, sensitizes nociceptive spinal neurons, and phosphorylates the transcription factor cAMP-responsive element binding protein (CREB), which initiates gene transcription. This study examined the role of the cAMP pathway in a model of chronic muscle pain by assessing associated behavioral changes and phosphorylation of CREB. Bilateral mechanical hyperalgesia of the paw was induced by administering two injections of acidic saline, 5 d apart, into the gastrocnemius muscle of male Sprague Dawley rats. Interestingly, the increases in immunoreactivity for CREB and phosphorylated CREB (p-CREB) in the spinal dorsal horn occur 24 hr, but not 1 week, after the second injection of acidic saline compared with pH 7.2 intramuscular injections. Spinal blockade of adenylate cyclase prevents the expected increase in p-CREB that occurs after intramuscular acid injection. The reversal of mechanical hyperalgesia by adenylate cyclase or protein kinase A inhibitors spinally follows a similar pattern with reversal at 24 hr, but not 1 week, compared with the vehicle controls. The p-CREB immunoreactivity in the superficial dorsal horn correlates with the mechanical withdrawal threshold such that increases in p-CREB are associated with decreases in threshold. Therefore, activation of the cAMP pathway in the spinal cord phosphorylates CREB and produces mechanical hyperalgesia associated with intramuscular acid injections. The mechanical hyperalgesia and phosphorylation of CREB depend on early activation of the cAMP pathway during the first 24 hr but are independent of the cAMP pathway by 1 week after intramuscular injection of acid.

  16. Glatiramer Injection

    MedlinePlus

    ... symptoms flare up from time to time) of multiple sclerosis (MS; a disease in which the nerves do ... minutes, but do not rub it. Glatiramer controls multiple sclerosis but does not cure it. Continue to use ...

  17. Is high-rate injection causing the increase in U.S. mid-continent seismicity?

    NASA Astrophysics Data System (ADS)

    Weingarten, M.; Ge, S.

    2014-12-01

    An unprecedented increase in earthquakes in the central and eastern US (CEUS) began in 2009. Many of these earthquakes have been documented as likely induced by wastewater injection. To better understand the likelihood of an induced seismic event from a given injection well, we compare the location and timing of earthquakes and injection operational parameters across the CEUS. We compiled a database of more than 187,000 injection wells in the CEUS, both active and inactive. In combination with the Advanced National Seismic System's (ANSS) comprehensive earthquake catalog from 1973 to mid-2014, we use spatial and temporal filtering methods to discriminate injection wells that may be associated with earthquakes from those that are not. Our goal was to understand whether or not well operational parameters such as injection rate, cumulative injected volume, injection pressure and injection depth affect the likelihood that a well is spatiotemporally associated with an earthquake. We found more than 14,000 injection wells (~8% of all wells) that may be associated with earthquakes in the CEUS. Our spatiotemporal filter succeeded in capturing every suspected case of induced seismicity that we are aware of. We also found that the likelihood of an injection well being associated with an earthquake increased with increasing injection rate and cumulative injected volume. This phenomenon was observed over a wide range of geologic and hydrogeologic provinces in states such as Oklahoma, Colorado, New Mexico and Arkansas. Operational parameters such as injection pressure and injection depth do not show a clear trend towards an increased likelihood of spatiotemporal association with an earthquake. In all, the cumulative number of CEUS earthquakes potentially associated with injection has risen sharply from 112 out of 545 in year 2000 (~19%) to more than 732 out of 1325 by May 2014 (~55%). This increase in earthquakes spatiotemporally associated with wells accounts for the vast

  18. The Effect of ShenQi FuZheng Injection in Combination with Chemotherapy versus Chemotherapy Alone on the Improvement of Efficacy and Immune Function in Patients with Advanced Non-Small Cell Lung Cancer: A Meta-Analysis

    PubMed Central

    dedong, Cao; huilin, Xu; Anbing, He; Ximing, Xu; wei, Ge

    2016-01-01

    Objective To evaluate the effect of ShenQi FuZheng Injection (SFI) on cellular immunity and clinical efficacy in patients with advanced non small cell lung cancer(NSCLC) when combined with chemotherapy. Methods Electronic databases including EMBASE, PUBMED, the conference proceedings of the American Society of Clinical Oncology (ASCO), Cochrane, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biological Medical disc(CBM) were searched, until July, 2015. The randomized controlled clinical studies reporting results of efficacy and immune function were collected according to the inclusion criteria. Cochrane handbook 5.1.0 was applied to assess the quality of included trials and Revman 5 software was used for data analysis. Results Fifteen studies including 1006 cases of advanced NSCLC were included based on the inclusion criteria. The results of meta-analysis showed that there were significant differences in percentages of CD3+ cells (SMD = 13.48; 95%CI: 8.11–18.85; p<0.01), CD4+ cells (SMD = 10.78; 95%CI, 6.38–15.18; p<0.01), NK [WMD = 8.59, 95% CI(3.97, 13.21), p = 0.003], and ratio of CD4+/ CD8+ (SMD = 0.32; 95%: 0.28–0.36; p<0.01) between SFI combination group and control group, whereas the difference was not significant in CD8+ (SMD = -1.44; 95%CI, -4.53–1.65; p = 0.36). Funnel plot, Begg's rank correlation test and Egger's linear regression analysis indicated that there was significant publication bias across studies. Conclusion SFI is effective to improve the efficacy of chemotherpay and function of cellular immunity in NSCLC patients, however, high quality RCTs are needed to further confirm the findings. PMID:27015629

  19. Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction

    PubMed Central

    Khattab, Ahmad; Islam, Mohammad Ariful; Hweij, Khaled Abou; Zeitouny, Joya; Waters, Renae; Sayegh, Malek; Hossain, Md Monowar; Paul, Arghya

    2015-01-01

    Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI. PMID:27668147

  20. Magnetic particle imaging: advancements and perspectives for real-time in vivo monitoring and image-guided therapy

    NASA Astrophysics Data System (ADS)

    Pablico-Lansigan, Michele H.; Situ, Shu F.; Samia, Anna Cristina S.

    2013-05-01

    Magnetic particle imaging (MPI) is an emerging biomedical imaging technology that allows the direct quantitative mapping of the spatial distribution of superparamagnetic iron oxide nanoparticles. MPI's increased sensitivity and short image acquisition times foster the creation of tomographic images with high temporal and spatial resolution. The contrast and sensitivity of MPI is envisioned to transcend those of other medical imaging modalities presently used, such as magnetic resonance imaging (MRI), X-ray scans, ultrasound, computed tomography (CT), positron emission tomography (PET) and single photon emission computed tomography (SPECT). In this review, we present an overview of the recent advances in the rapidly developing field of MPI. We begin with a basic introduction of the fundamentals of MPI, followed by some highlights over the past decade of the evolution of strategies and approaches used to improve this new imaging technique. We also examine the optimization of iron oxide nanoparticle tracers used for imaging, underscoring the importance of size homogeneity and surface engineering. Finally, we present some future research directions for MPI, emphasizing the novel and exciting opportunities that it offers as an important tool for real-time in vivo monitoring. All these opportunities and capabilities that MPI presents are now seen as potential breakthrough innovations in timely disease diagnosis, implant monitoring, and image-guided therapeutics.

  1. Application of the advanced communications technology satellite to teleradiology and real-time compressed ultrasound video telemedicine.

    PubMed

    Stewart, B K; Carter, S J; Cook, J N; Abbe, B S; Pinck, D; Rowberg, A H

    1999-05-01

    The authors have investigated the application of the NASA Advanced Communications Technology Satellite (ACTS) to teleradiology and telemedicine using the Jet Propulsion Laboratory (JPL)-developed ACTS Mobile Terminal (AMT) uplink. In this experiment, bidirectional 128, 256, and 384 kbps satellite links were established between the ACTS/AMT, the ACTS in geosynchronous orbit, and the downlink terrestrial terminal at JPL. A terrestrial Integrated Digital Services Network (ISDN) link was established from JPL to the University of Washington Department of Radiology to complete the bidirectional connection. Ultrasound video imagery was compressed in real-time using video codecs adhering to the International Telecommunication Union-Telecommunication Standardization Sector (ITU-T) Recommendation H.261. A 16 kbps in-band audio channel was used throughout. A five-point Likert scale was used to evaluate the quality of the compressed ultrasound imagery at the three transmission bandwidths (128, 256, and 384 kbps). The central question involved determination of the bandwidth requirements to provide sufficient spatial and contrast resolution for the remote visualization of fine- and low-contrast objects. The 384 kbps bandwidth resulted in only slight tiling artifact and fuzziness owing to the quantizer step size; however, these motion artifacts were rapidly resolved in time at this bandwidth. These experiments have demonstrated that real-time compressed ultrasound video imagery can be transmitted over multiple ISDN line bandwidth links with sufficient temporal, contrast, and spatial resolution for clinical diagnosis of multiple disease and pathology states to provide subspecialty consultation and educational at a distance.

  2. Superselective embolization of superior gluteal artery pseudoaneurysms following intramuscular injection: case report.

    PubMed

    Vauthey, J N; Maddern, G J; Balsiger, D; Blumgart, L H; Triller, J

    1991-08-01

    Two bleeding superior gluteal artery pseudoaneurysms occurred in a patient with advanced malignant disease following an intramuscular injection. This was diagnosed by angiography and successfully managed by superselective embolization. This avoided further surgery and no additional complication from the pseudoaneurysm occurred up to the time of the patient's demise.

  3. Hyaluronidase inhibitors (sodium cromoglycate and sodium auro-thiomalate) reduce the local tissue damage and prolong the survival time of mice injected with Naja kaouthia and Calloselasma rhodostoma venoms.

    PubMed

    Yingprasertchai, Senee; Bunyasrisawat, Srisurat; Ratanabanangkoon, Kavi

    2003-11-01

    Experiments have been carried out to find potent inhibitors of hyaluronidases of Naja kaouthia (NK) and Calloselasma rhodostoma (CR) venoms with the aim of reducing local tissue damage and systemic toxicities caused by the venoms. Seven drugs/chemicals known to inhibit hyaluronidases were tested for their activity on venom enzymes. These were: sodium cromoglycate (SC), sodium aurothiomalate (SAT), apigenin, kaemferol, phenylbutazone, oxyphenbutazone and fenoprofen. The results showed that SC or SAT at 10 mM, completely inhibited the enzymes of both venoms. In in vivo experiments, SC or SAT, when incubated with NK venom prior to injection, significantly reduced edema and myonecrosis. In the case of CR venom, hemorrhage, in addition to edema and myonecrosis, was also significantly reduced. In the independent type experiment, SC or SAT were effective if injected within 1 min after the injection of venom. At longer time intervals of 3 and 10 min the inhibitors were effective in reducing some parameters of local tissue necrosis but the extent of inhibition was lower. SC and SAT at 256 and 195 microg/mouse, respectively, significantly prolonged the survival time of mice receiving lethal doses of NK. In the case of CR venoms, the two inhibitors not only prolonged the survival time but also prevented death of mice receiving lethal doses of the venom. The other inhibitors were poorly soluble in water and were studied only on enzyme inhibition and prolongation of survival time; they were mostly ineffective. Thus, SC and SAT when injected immediately at the sites of bites can reduce the systemic and local toxicity of NK and CR venoms. These results suggest that administration of these drugs at the site of venom injection may be useful in reducing venom-induced local tissue damage.

  4. Effects of in ovo injection of organic trace minerals and post-hatch holding time on broiler performance and bone characteristics

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Effects of the in ovo injection of organic Mn, Zn, and Cu in association with post-hatch (POH) feed and water restriction on the performance and physical-chemical bone parameters of male Ross × Ross 708 broilers were examined. On 17 d of incubation, a total of 1,872 eggs were subjected to in ovo inj...

  5. Advances in Web-Based, Near Real-Time Climate Data Ingest For NOAA's Cooperative Volunteer Observation Network

    NASA Astrophysics Data System (ADS)

    Owen, T.; Brewer, M.; Redmond, K.; McCurdy, G.; Kelly, G.; Bonack, B.; Somrek, B.; Doesken, N.; Bollinger, J.

    2006-12-01

    NOAA is charged with collection, preservation and accessibility of a quality digital record of Cooperative Network data and metadata. This record has historically been derived through the imaging and keying of so- called "B-91' forms that are sent by observers and the National Weather Service to the National Climatic Data Center (NCDC). The processing time, including quality assurance checks and serial publication, typically is 45-60 days beyond the data month. Technological and communication advances, coupled with integrated climate and weather and water reporting needs have reached a threshold where near real-time (i.e., daily) reporting of observations is desirable. While ASOS data have long been directly reported to NCDC in this time horizon, National Weather Service Cooperative Network (COOP) data has continued to be recorded on forms. Timely data reporting is fundamental to the success of the U.S. effort in Global Earth Observations, especially for monitoring drought as part of the National Integrated Drought Information System (NIDIS). Coupled with implementation planning for transition of Legacy COOP under NOAA's Environmental Real-Time Observing Network (NERON), work toward such a system is timely. NOAA is working closely with Regional Climate Centers, State Climatologists and other partners to develop a web-based interface based on existing systems (e.g., WxCoder, CoCoRAHS and COOLTAP) to provide for the electronic submission of daily COOP data to NCDC and the climate community. To this end, the following guiding principles have been identified: 1) Provide efficient, easy-to-use data entry system for participating COOP observers, 2) Ensure timely availability of COOP data for all customers, 3) Improve data quality through automated near-real-time data QA/QC, 4) Achieve a paperless electronic data collection, transmission, and archiving system. 5) Allow system flexibility to meet demands of integrating data from future observing systems This presentation

  6. 252Cf fission-neutron spectrum using a simplified time-of-flight setup: An advanced teaching laboratory experiment

    NASA Astrophysics Data System (ADS)

    Becchetti, F. D.; Febbraro, M.; Torres-Isea, R.; Ojaruega, M.; Baum, L.

    2013-02-01

    The removal of PuBe and AmBe neutron sources from many university teaching laboratories (due to heightened security issues) has often left a void in teaching various aspects of neutron physics. We have recently replaced such sources with sealed 252Cf oil-well logging sources (nominal 10-100 μCi), and developed several experiments using them as neutron sources. This includes a fission-neutron time-of-flight experiment using plastic scintillators, which utilizes the prompt γ rays emitted in 252Cf spontaneous fission as a fast timing start signal. The experiment can be performed with conventional nuclear instrumentation and a 1-D multi-channel pulse-height analyzer, available in most advanced teaching laboratories. Alternatively, a more sophisticated experiment using liquid scintillators and n/γ pulse-shape discrimination can be performed. Several other experiments using these neutron sources are also feasible. The experiments can introduce students to the problem of detecting the dark matter thought to dominate the universe and to the techniques used to detect contraband fissionable nuclear materials.

  7. A comparison of molding procedures - Contact, injection and vacuum injection

    NASA Astrophysics Data System (ADS)

    Cathiard, G.

    1980-06-01

    The technical and economic aspects of the contact, injection and vacuum injection molding of reinforced plastic components are compared for the example of a tractor roof with a gel-coated surface. Consideration is given to the possibility of reinforcement, number of smooth faces, condition of the gel-coated surface, reliability, and labor and workplace requirements of the three processes, and advantages of molding between the mold and a countermold in smooth faces, reliability, labor requirements, working surface and industrial hygiene are pointed out. The times and labor requirements of each step in the molding cycles are examined, and material requirements and yields, investment costs, amortization and product cost prices of the processes are compared. It is concluded that, for the specific component examined, the processes of vacuum injection and injection molding appear very interesting, with injection molding processes resulting in lower cost prices than contact molding for any production volume.

  8. MR-trackable intramyocardial injection catheter.

    PubMed

    Karmarkar, P V; Kraitchman, D L; Izbudak, I; Hofmann, L V; Amado, L C; Fritzges, D; Young, R; Pittenger, M; Bulte, J W M; Atalar, E

    2004-06-01

    There is growing interest in delivering cellular agents to infarcted myocardium to prevent postinfarction left ventricular remodeling. MRI can be effectively used to differentiate infarcted from healthy myocardium. MR-guided delivery of cellular agents/therapeutics is appealing because the therapeutics can be precisely targeted to the desired location within the infarct. In this study, a steerable intramyocardial injection catheter that can be actively tracked under MRI was developed and tested. The components of the catheter were arranged to form a loopless RF antenna receiver coil that enabled active tracking. Feasibility studies were performed in canine and porcine myocardial infarction models. Myocardial delayed-enhancement (MDE) imaging identified the infarcted myocardium, and real-time MRI was used to guide left ventricular catheterization from a carotid artery approach. The distal 35 cm of the catheter was seen under MRI with a bright signal at the distal tip of the catheter. The catheter was steered into position, the distal tip was apposed against the infarct, the needle was advanced, and a bolus of MR contrast agent and tissue marker dye was injected intramyocardially, as confirmed by imaging and postmortem histology. A pilot study involving intramyocardial delivery of magnetically labeled stem cells demonstrated the utility of the active injection catheter system.

  9. Abatacept Injection

    MedlinePlus

    ... with daily activities, and joint damage caused by rheumatoid arthritis (a condition in which the body attacks its ... that fight infection). People who have had severe rheumatoid arthritis for a long time may have a greater ...

  10. Air injection system diagnostic

    SciTech Connect

    Kotzan, J.M.; Labus, G.E.

    1992-05-19

    This patent describes a method for diagnosing failures in an air control system that controls a quantity of air admitted into an exhaust path of an internal combustion engine. It comprises sensing the oxygen content of the exhaust gas of the engine at predetermined time intervals at a first predetermined point in the exhaust path of the engine, the oxygen content normally oscillating between a rich oxygen condition and a lean oxygen condition in the absence of air injected into the exhaust path above the first predetermined point; injecting a quantity of air into the exhaust path of the engine at a second predetermined point in the exhaust port, the second predetermined point being above the first predetermined point; counting the number of intervals at which the sensed oxygen content indicates a rich oxygen condition over a predetermined period of time; comparing the counted number of rich oxygen intervals to a predetermined threshold value, the threshold value being greater than a counted number of rich oxygen intervals over the predetermined period of time resulting from the normal oscillations between rich and lean oxygen conditions in the absence of air injected into the exhaust path; indicating the existence of a fault in the air control system when the number of rich oxygen intervals does not exceed the predetermined threshold value.

  11. Snowplow Injection Front Effects

    NASA Technical Reports Server (NTRS)

    Moore, T. E.; Chandler, M. O.; Buzulukova, N.; Collinson, G. A.; Kepko, E. L.; Garcia-Sage, K. S.; Henderson, M. G.; Sitnov, M. I.

    2013-01-01

    As the Polar spacecraft apogee precessed through the magnetic equator in 2001, Polar encountered numerous substorm events in the region between geosynchronous orbit and 10 RE geocentric distance; most of them in the plasma sheet boundary layers. Of these, a small number was recorded near the neutral sheet in the evening sector. Polar/Thermal Ion Dynamics Experiment provides a unique perspective on the lowest-energy ion plasma, showing that these events exhibited a damped wavelike character, initiated by a burst of radially outward flow transverse to the local magnetic field at approximately 80 km/s. They then exhibit strongly damped cycles of inward/outward flow with a period of several minutes. After one or two cycles, they culminated in a hot plasma electron and ion injection, quite similar to those observed at geosynchronous orbit. Cold plasmaspheric plasmas comprise the outward flow cycles, while the inward flow cycles contain counterstreaming field-parallel polar wind-like flows. The observed wavelike structure, preceding the arrival of an earthward moving substorm injection front, suggests an outward displacement driven by the inward motion at local times closer to midnight, that is, a "snowplow" effect. The damped in/out flows are consistent with interchange oscillations driven by the arrival at the observed local time by an injection originating at greater radius and local time.

  12. Characterization and quantitative amino acids analysis of analgesic peptides in cinobufacini injection by size exclusion chromatography, matrix-assisted laser desorption/ionization time of flight mass spectrometry and gas chromatography mass spectrometry.

    PubMed

    Wu, Xu; Si, Nan; Bo, Gao; Hu, Hao; Yang, Jian; Bian, Baolin; Zhao, Hai Yu; Wang, Hongjie

    2015-01-01

    Cinobufacini injection that comes from the water extract of Bufo bufo gargarizans Cantor skin is widely used for cancer treatment in China. Peptide is one of its major types of constituents, however the biological effects and content of this injection are little reported. In present study, the analgesic effect of peptides was determined and evaluated by in-vivo models. To characterize and quantitatively analyze these peptides, a reliable and efficient method combining size exclusion chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry with amino acid analysis was developed. The peptides presented as a series of analogs with similar molecular weights mostly ranging from 2 to 8 kDa. The amino acid analysis by gas chromatography mass spectrometry (GC-MS) was developed to determine both free and combined amino acids (FAA and CAA) in cinobufacini injection. This method achieved good linearity (R(2) , 0.9909-0.9999) and low limit of detection and quantification. FAA and CAA samples were efficiently analyzed by modified Phenomenex EZ: faast procedure. For the sample analysis, the method showed good repeatability (relative standard deviation, RSD ≤ 10%). For most FAA and CAA the mean recoveries were >80% with RSD <10%. The GC-MS based method is useful for quality assurance of both FAA and CAA in cinobufacini injection.

  13. A fast-time-response extreme ultraviolet spectrometer for measurement of impurity line emissions in the Experimental Advanced Superconducting Tokamak

    SciTech Connect

    Zhang, Ling; Xu, Zong; Wu, Zhenwei; Zhang, Pengfei; Wu, Chengrui; Gao, Wei; Shen, Junsong; Chen, Yingjie; Liu, Xiang; Wang, Yumin; Gong, Xianzu; Hu, Liqun; Chen, Junlin; Zhang, Xiaodong; Wan, Baonian; Li, Jiangang; Morita, Shigeru; Ohishi, Tetsutarou; Goto, Motoshi; Dong, Chunfeng; and others

    2015-12-15

    A flat-field extreme ultraviolet (EUV) spectrometer working in the 20-500 Å wavelength range with fast time response has been newly developed to measure line emissions from highly ionized tungsten in the Experimental Advanced Superconducting Tokamak (EAST) with a tungsten divertor, while the monitoring of light and medium impurities is also an aim in the present development. A flat-field focal plane for spectral image detection is made by a laminar-type varied-line-spacing concave holographic grating with an angle of incidence of 87°. A back-illuminated charge-coupled device (CCD) with a total size of 26.6 × 6.6 mm{sup 2} and pixel numbers of 1024 × 255 (26 × 26 μm{sup 2}/pixel) is used for recording the focal image of spectral lines. An excellent spectral resolution of Δλ{sub 0} = 3-4 pixels, where Δλ{sub 0} is defined as full width at the foot position of a spectral line, is obtained at the 80-400 Å wavelength range after careful adjustment of the grating and CCD positions. The high signal readout rate of the CCD can improve the temporal resolution of time-resolved spectra when the CCD is operated in the full vertical binning mode. It is usually operated at 5 ms per frame. If the vertical size of the CCD is reduced with a narrow slit, the time response becomes faster. The high-time response in the spectral measurement therefore makes possible a variety of spectroscopic studies, e.g., impurity behavior in long pulse discharges with edge-localized mode bursts. An absolute intensity calibration of the EUV spectrometer is also carried out with a technique using the EUV bremsstrahlung continuum at 20-150 Å for quantitative data analysis. Thus, the high-time resolution tungsten spectra have been successfully observed with good spectral resolution using the present EUV spectrometer system. Typical tungsten spectra in the EUV wavelength range observed from EAST discharges are presented with absolute intensity and spectral identification.

  14. A fast-time-response extreme ultraviolet spectrometer for measurement of impurity line emissions in the Experimental Advanced Superconducting Tokamak.

    PubMed

    Zhang, Ling; Morita, Shigeru; Xu, Zong; Wu, Zhenwei; Zhang, Pengfei; Wu, Chengrui; Gao, Wei; Ohishi, Tetsutarou; Goto, Motoshi; Shen, Junsong; Chen, Yingjie; Liu, Xiang; Wang, Yumin; Dong, Chunfeng; Zhang, Hongmin; Huang, Xianli; Gong, Xianzu; Hu, Liqun; Chen, Junlin; Zhang, Xiaodong; Wan, Baonian; Li, Jiangang

    2015-12-01

    A flat-field extreme ultraviolet (EUV) spectrometer working in the 20-500 Å wavelength range with fast time response has been newly developed to measure line emissions from highly ionized tungsten in the Experimental Advanced Superconducting Tokamak (EAST) with a tungsten divertor, while the monitoring of light and medium impurities is also an aim in the present development. A flat-field focal plane for spectral image detection is made by a laminar-type varied-line-spacing concave holographic grating with an angle of incidence of 87°. A back-illuminated charge-coupled device (CCD) with a total size of 26.6 × 6.6 mm(2) and pixel numbers of 1024 × 255 (26 × 26 μm(2)/pixel) is used for recording the focal image of spectral lines. An excellent spectral resolution of Δλ0 = 3-4 pixels, where Δλ0 is defined as full width at the foot position of a spectral line, is obtained at the 80-400 Å wavelength range after careful adjustment of the grating and CCD positions. The high signal readout rate of the CCD can improve the temporal resolution of time-resolved spectra when the CCD is operated in the full vertical binning mode. It is usually operated at 5 ms per frame. If the vertical size of the CCD is reduced with a narrow slit, the time response becomes faster. The high-time response in the spectral measurement therefore makes possible a variety of spectroscopic studies, e.g., impurity behavior in long pulse discharges with edge-localized mode bursts. An absolute intensity calibration of the EUV spectrometer is also carried out with a technique using the EUV bremsstrahlung continuum at 20-150 Å for quantitative data analysis. Thus, the high-time resolution tungsten spectra have been successfully observed with good spectral resolution using the present EUV spectrometer system. Typical tungsten spectra in the EUV wavelength range observed from EAST discharges are presented with absolute intensity and spectral identification.

  15. Olanzapine Injection

    MedlinePlus

    ... in people who have bipolar I disorder (manic depressive disorder; a disease that causes episodes of depression, episodes ... high blood sugar, diabetes, or liver or prostate disease. Tell your doctor if ... you develop these symptoms at any time during your treatment. Also tell ...

  16. An advanced joint inversion system for CO2 storage modeling with large date sets for characterization and real-time monitoring-enhancing storage performance and reducing failure risks under uncertainties

    SciTech Connect

    Kitanidis, Peter

    2016-04-30

    As large-scale, commercial storage projects become operational, the problem of utilizing information from diverse sources becomes more critically important. In this project, we developed, tested, and applied an advanced joint data inversion system for CO2 storage modeling with large data sets for use in site characterization and real-time monitoring. Emphasis was on the development of advanced and efficient computational algorithms for joint inversion of hydro-geophysical data, coupled with state-of-the-art forward process simulations. The developed system consists of (1) inversion tools using characterization data, such as 3D seismic survey (amplitude images), borehole log and core data, as well as hydraulic, tracer and thermal tests before CO2 injection, (2) joint inversion tools for updating the geologic model with the distribution of rock properties, thus reducing uncertainty, using hydro-geophysical monitoring data, and (3) highly efficient algorithms for directly solving the dense or sparse linear algebra systems derived from the joint inversion. The system combines methods from stochastic analysis, fast linear algebra, and high performance computing. The developed joint inversion tools have been tested through synthetic CO2 storage examples.

  17. Near minimum-time maneuvers of the advanced space structures technology research experiment (ASTREX) test article: Theory and experiments

    NASA Technical Reports Server (NTRS)

    Vadali, Srinivas R.; Carter, Michael T.

    1994-01-01

    The Phillips Laboratory at the Edwards Air Force Base has developed the Advanced Space Structures Technology Research Experiment (ASTREX) facility to serve as a testbed for demonstrating the applicability of proven theories to the challenges of spacecraft maneuvers and structural control. This report describes the work performed on the ASTREX test article by Texas A&M University under contract NAS119373 as a part of the Control-Structure Interaction (CSI) Guest Investigator Program. The focus of this work is on maneuvering the ASTREX test article with compressed air thrusters that can be throttled, while attenuating structural excitation. The theoretical foundation for designing the near minimum-time thrust commands is based on the generation of smooth, parameterized optimal open-loop control profiles, and the determination of control laws for final position regulation and tracking using Lyapunov stability theory. Details of the theory, mathematical modeling, model updating, and compensation for the presence of 'real world' effects are described and the experimental results are presented. The results show an excellent match between theory and experiments.

  18. Design and implementation of a CO{sub 2} flood utilizing advanced reservoir characterization and horizontal injection wells in a shallow shelf carbonate approaching waterflood depletion. Annual report, June 3, 1994--October 31, 1995

    SciTech Connect

    Hallenbeck, L.D.; Harpole, K.J.; Gerard, M.G.

    1996-05-01

    The work reported here covers Budget Phase I of the project. The principal tasks in Budget Phase I are the Reservoir Analysis and Characterization Task and the Advanced Technology Definition Task. Completion of these tasks have enabled an optimum carbon dioxide (CO{sub 2}) flood project to be designed and evaluated from an economic and risk analysis standpoint. Field implementation of the project has been recommended to the working interest owner of the South Cowden Unit (SCU) and approval has been obtained. The current project has focused on reducing initial investment cost by utilizing horizontal injection wells and concentrating the project in the best productivity area of the field. An innovative CO{sub 2} purchase agreement (no take or pay requirements, CO{sub 2} purchase price tied to West Texas Intermediate crude oil price) and gas recycle agreements (expensing cost as opposed to large capital investments for compression) were negotiated to further improve project economics. A detailed reservoir characterization study was completed by an integrated team of geoscientists and engineers. The study consisted of detailed core description, integration of log response to core descriptions, mapping of the major flow units, evaluation of porosity and permeability relationships, geostatistical analysis of permeability trends, and direct integration of reservoir performance with the geological interpretation. The study methodology fostered iterative bidirectional feedback between the reservoir characterization team and the reservoir engineering/simulation team to allow simultaneous refinement and convergence of the geological interpretation with the reservoir model. The fundamental conclusion from the study is that South Cowden exhibits favorable enhanced oil recovery characteristics, particularly reservoir quality and continuity.

  19. Dietary flavonoids advance timing of moult but do not affect redox status of juvenile blackbirds (Turdus merula).

    PubMed

    Cecere, Jacopo G; Caprioli, Manuela; Carnevali, Chiara; Colombo, Graziano; Dalle-Donne, Isabella; Mancuso, Elisa; Milzani, Aldo; Parolini, Marco; Portanova, Antea; Saino, Nicola; Serra, Lorenzo; Rubolini, Diego

    2016-10-01

    Flavonoids are the most abundant plant polyphenols, widely occurring in fruits and berries, and show a strong antioxidant activity in vitro Studies of avian species feeding on berries suggest that dietary flavonoids have health-promoting effects and may enhance the expression of melanin-based plumage traits. These effects are probably mediated by the antioxidant activity of flavonoids. However, the effect of dietary flavonoids on oxidative status has never been investigated in any bird species. We analysed the effects of dietary flavonoids on blood non-enzymatic antioxidants and protein oxidative damage of juvenile European blackbirds (Turdus merula). In addition, we analysed the effects of flavonoid-enriched diet on body condition and on the timing of moult from juvenile to adult plumage. Dietary flavonoids did not significantly affect redox status but significantly advanced the onset of moult, hastening plumage development. Moulting birds showed higher protein oxidative damage compared with those that had not yet started moulting. The probability of initiating moult after 40 days of dietary treatment was higher for birds with low circulating levels of oxidizing agents and high glutathione concentration. The metabolization of flavonoids could have altered their redox potential, resulting in no net effects on redox status. However, flavonoid consumption before and during moult may contribute to enhance plumage development. Moreover, our findings suggest that moulting feathers may result in redox imbalance. Given their effect on moult and growth of melanin-rich feathers, fruit flavonoids may have contributed to shape plant fruiting time in relation to fruit consumption preferences by birds.

  20. Implications of the Index Cholecystectomy and Timing of Referral for Radical Resection of Advanced Incidental Gallbladder Cancer

    PubMed Central

    Ausania, F; White, SA; French, JJ; Jaques, BC; Charnley, RM; Manas, DM

    2015-01-01

    Introduction Advanced (pT2/T3) incidental gallbladder cancer is often deemed unresectable after restaging. This study assesses the impact of the primary operation, tumour characteristics and timing of management on re-resection. Methods The records of 60 consecutive referrals for incidental gallbladder cancer in a single tertiary centre from 2003 to 2011 were reviewed retrospectively. Decision on re-resection of incidental gallbladder cancer was based on delayed interval restaging at three months following cholecystectomy. Demographics, index cholecystectomy data, primary pathology, CA19–9 tumour marker levels at referral and time from cholecystectomy to referral as well as from referral to restaging were analysed. Results Thirty-seven patients with pT2 and twelve patients with pT3 incidental gallbladder cancer were candidates for radical re-resection. Following interval restaging, 24 patients (49%) underwent radical resection and 25 (51%) were deemed inoperable. The inoperable group had significantly more patients with positive resection margins at cholecystectomy (p=0.002), significantly higher median CA19–9 levels at referral (p=0.018) and were referred significantly earlier (p=0.004) than the patients who had resectable tumours. On multivariate analysis, urgent referral (p=0.036) and incomplete cholecystectomy (p=0.048) were associated significantly with inoperable disease following restaging. Conclusions In patients with incidental, potentially resectable, pT2/T3 gallbladder cancer, inappropriate index cholecystectomy may have a significant impact on tumour dissemination. Early referral of breached tumours is not associated with resectability. PMID:25723690