Science.gov

Sample records for advanced maintenance advisory

  1. 75 FR 57742 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... Advanced Scientific Computing Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION... Scientific Computing Advisory Committee (ASCAC). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770...: Melea Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown Building;...

  2. 76 FR 45786 - Advanced Scientific Computing Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... Advanced Scientific Computing Advisory Committee; Meeting AGENCY: Office of Science, Department of Energy... Computing Advisory Committee (ASCAC). Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770) requires... INFORMATION CONTACT: Melea Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown...

  3. Advanced servomanipulator remote maintenance demonstration

    SciTech Connect

    Ray, T.L.; Bradley, E.C.

    1989-03-01

    The advanced servomanipulator (ASM) is a dual-arm, force-reflecting, master/slave servomanipulator that was designed for remote maintenance applications and is digitally controlled. The ASM is installed in the Maintenance Systems Test Area (MSTA) of the Fuel Recycle Division at the Oak Ridge National Laboratory. The unique aspect of ASM is that the slave arms were designed to be remotely maintainable, using a similar remote manipulator system, to maximize availability and minimize downtime. This test report describes the results of the maintenance testing conducted on ASM. Demonstration of the ability to maintain ASM remotely is an important precursor to the ultimate application of ASM in a totally remote facility. The approach taken in the design of ASM was for the manipulator slave arms to be composed of modules capable of being removed and replaced by another manipulator system of similar capabilities. The ASM incorporates gear and torque tube drives with drive couplings that facilitate remote maintenance. Although the use of special fixtures is normally discouraged for remote maintenance, special fixtures were required for this demonstration due to the complex nature of the slave arms. This test was performed to demonstrate that the ASM slave arms could be completely disassembled and reassembled remotely. Maintenance of ASM was successfully demonstrated using the M-2 servomanipulator and special fixtures. The entire disassembly process took about 4 h, and the assembly took about 3 1/2 h. Although there were some problems, in general, the arm modules were adequately designed for remote removal and replacement. Recommendations, which are documented in this report, have been made for improvements. 5 refs., 22 figs., 1 tab.

  4. 75 FR 43518 - Advanced Scientific Computing Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... Advanced Scientific Computing Advisory Committee; Meeting AGENCY: Office of Science, DOE. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Advanced Scientific Computing Advisory..., Office of Advanced Scientific Computing Research; SC-21/Germantown Building; U. S. Department of...

  5. 76 FR 41234 - Advanced Scientific Computing Advisory Committee Charter Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... Advanced Scientific Computing Advisory Committee Charter Renewal AGENCY: Department of Energy, Office of... Administration, notice is hereby given that the Advanced Scientific Computing Advisory Committee will be renewed... concerning the Advanced Scientific Computing program in response only to charges from the Director of...

  6. Advanced Tools for Software Maintenance.

    DTIC Science & Technology

    1982-12-01

    Old Applications ...... 118 11.3.3 Training People to Use New Tools ......... 119 Appendix A. Ada Style Guidelines . . . . . . . . . . . . . 121...and application -specific programming techniques and methods. - The Intelligent Editor provides facilities for manipulating programs at several...are applicable today or in the near future. In identifying tools and techniques, this study focused on one aspect of the maintenance problem

  7. 75 FR 64720 - DOE/Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    .../Advanced Scientific Computing Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Advanced Scientific Computing... Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown Building; U. S. Department...

  8. 76 FR 9765 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... Advanced Scientific Computing Advisory Committee AGENCY: Office of Science, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Advanced Scientific Computing..., Office of Advanced Scientific Computing Research, SC-21/Germantown Building, U.S. Department of...

  9. 77 FR 45345 - DOE/Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-31

    .../Advanced Scientific Computing Advisory Committee AGENCY: Office of Science, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Advanced Scientific Computing... Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown Building; U.S. Department...

  10. An advanced maintenance free aircraft battery system

    SciTech Connect

    Beutler, J.; Green, J.; Kulin, T.

    1996-11-01

    This paper describes an advanced aircraft battery system designed to provide 20 years of maintenance free operation with the flexibility for use on all US Air Force aircraft. System, battery, and charger/analyzer requirements are identified. The final design approach and test results are also presented. There are two general approaches to reduce the maintenance cost of batteries. One approach is to develop a disposable battery system, such that after some time interval the battery is simply replaced. The other approach, the subject of this paper, is to develop a battery that does not require any scheduled maintenance for the design life of the aircraft. This approach is currently used in spacecraft applications where battery maintenance is not practical.

  11. 77 FR 12823 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-02

    ... final report, Advanced Networking update Status from Computer Science COV Early Career technical talks Summary of Applied Math and Computer Science Workshops ASCR's new SBIR awards Data-intensive Science... Advanced Scientific Computing Advisory Committee AGENCY: Department of Energy, Office of Science. ACTION...

  12. Advanced Ground Systems Maintenance Prognostics Project

    NASA Technical Reports Server (NTRS)

    Perotti, Jose M.

    2015-01-01

    The project implements prognostics capabilities to predict when a component system or subsystem will no longer meet desired functional or performance criteria, called the end of life. The capability also provides an assessment of the remaining useful life of a hardware component. The project enables the delivery of system health advisories to ground system operators. This project will use modeling techniques and algorithms to assess components' health andpredict remaining life for such components. The prognostics capability being developed will beused:during the design phase and during pre/post operations to conduct planning and analysis ofsystem design, maintenance & logistics plans, and system/mission operations plansduring real-time operations to monitor changes to components' health and assess their impacton operations.This capability will be interfaced to Ground Operations' command and control system as a part ofthe AGSM project to help assure system availability and mission success. The initial modelingeffort for this capability will be developed for Liquid Oxygen ground loading applications.

  13. 78 FR 56871 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-16

    ... Advanced Scientific Computing Advisory Committee AGENCY: Office of Science, Department of Energy. ACTION... Exascale technical approaches subcommittee Facilities update Report from Applied Math Committee of Visitors...: ( Melea.Baker@science.doe.gov ). You must make your request for an oral statement at least five...

  14. Plant maintenance and advanced reactors issue, 2008

    SciTech Connect

    Agnihotri, Newal

    2009-09-15

    The focus of the September-October issue is on plant maintenance and advanced reactors. Major articles/reports in this issue include: Technologies of national importance, by Tsutomu Ohkubo, Japan Atomic Energy Agency, Japan; Modeling and simulation advances brighten future nuclear power, by Hussein Khalil, Argonne National Laboratory, Energy and desalination projects, by Ratan Kumar Sinha, Bhabha Atomic Research Centre, India; A plant with simplified design, by John Higgins, GE Hitachi Nuclear Energy; A forward thinking design, by Ray Ganthner, AREVA; A passively safe design, by Ed Cummins, Westinghouse Electric Company; A market-ready design, by Ken Petrunik, Atomic Energy of Canada Limited, Canada; Generation IV Advanced Nuclear Energy Systems, by Jacques Bouchard, French Commissariat a l'Energie Atomique, France, and Ralph Bennett, Idaho National Laboratory; Innovative reactor designs, a report by IAEA, Vienna, Austria; Guidance for new vendors, by John Nakoski, U.S. Nuclear Regulatory Commission; Road map for future energy, by John Cleveland, International Atomic Energy Agency, Vienna, Austria; and, Vermont's largest source of electricity, by Tyler Lamberts, Entergy Nuclear Operations, Inc. The Industry Innovation article is titled Intelligent monitoring technology, by Chris Demars, Exelon Nuclear.

  15. Advanced Ground Systems Maintenance Physics Models For Diagnostics Project

    NASA Technical Reports Server (NTRS)

    Perotti, Jose M.

    2015-01-01

    The project will use high-fidelity physics models and simulations to simulate real-time operations of cryogenic and systems and calculate the status/health of the systems. The project enables the delivery of system health advisories to ground system operators. The capability will also be used to conduct planning and analysis of cryogenic system operations. This project will develop and implement high-fidelity physics-based modeling techniques tosimulate the real-time operation of cryogenics and other fluids systems and, when compared to thereal-time operation of the actual systems, provide assessment of their state. Physics-modelcalculated measurements (called “pseudo-sensors”) will be compared to the system real-timedata. Comparison results will be utilized to provide systems operators with enhanced monitoring ofsystems' health and status, identify off-nominal trends and diagnose system/component failures.This capability can also be used to conduct planning and analysis of cryogenics and other fluidsystems designs. This capability will be interfaced with the ground operations command andcontrol system as a part of the Advanced Ground Systems Maintenance (AGSM) project to helpassure system availability and mission success. The initial capability will be developed for theLiquid Oxygen (LO2) ground loading systems.

  16. Plant maintenance and advanced reactors, 2007

    SciTech Connect

    Agnihotri, Newal

    2007-09-15

    The focus of the September-October issue is on plant maintenance and advanced reactors. Major articles/reports in this issue include: A new day for energy in America; Committed to success more than ever, by Andy White, GE--Hitachi Nuclear Energy; Competitive technology for decades, by Steve Tritch, Westinghouse Electric Company; Pioneers of positive community relationship, by Exelon Nuclear; A robust design for 60-years, by Ray Ganthner, Areva; Aiming at no evacuation plants, by Kumiaki Moriya, Hitachi-GE Nuclear Energy, Ltd.; and, Desalination and hydrogen economy, by Dr. I. Khamis, International Atomic Energy Agency. Industry innovation articles in this issue are: Reactor vessel closure head project, by Jeff LeClair, Prairie Island Nuclear Generating Plant; and Submersible remote-operated vehicle, by Michael S. Rose, Entergy's Fitzpatrick Nuclear Station.

  17. 78 FR 37595 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR.... Kathy Weaver, Acting Chief, Technical Support Branch, Advisory Committee on Reactor Safeguards....

  18. 76 FR 5218 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR); Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor... inconvenience. Dated: January 24, 2011. Antonio Dias, Chief, Reactor Safety Branch B, Advisory Committee...

  19. 77 FR 59678 - Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... COMMISSION Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR... Branch, Advisory Committee on Reactor Safeguards. BILLING CODE 7590-01-P...

  20. 78 FR 20959 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-08

    ... COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting.... Antonio Dias, Technical Advisor, Advisory Committee on Reactor Safeguards. BILLING CODE 7590-01-P...

  1. 77 FR 76089 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR... Committee on Reactor Safeguards. BILLING CODE 7590-01-P...

  2. 76 FR 18585 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-04

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR); Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water...

  3. 75 FR 10840 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the Subcommittee on Advanced Boiling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the Subcommittee on Advanced Boiling Water Reactor (ABWR); Notice of Meeting The ACRS Subcommittee on ABWR will hold a meeting on March 18... 3, 2010. Antonio F. Dias, Chief, Reactor Safety Branch B, Advisory Committee on Reactor...

  4. 75 FR 7632 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the Subcommittee on Advanced Boiling...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the Subcommittee on Advanced Boiling Water Reactor (ABWR) The ACRS Subcommittee on ABWR will hold a meeting on March 2, 2010, at 11545...: February 12, 2010. Antonio F. Dias, Chief Reactor Safety Branch B, Advisory Committee on Reactor...

  5. 76 FR 34276 - Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on June 21, 2011, Room T-2B1,...

  6. 75 FR 66803 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-29

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR); Notice of Meeting The ACRS Subcommittee on ABWR will hold a meeting...

  7. Advanced Technology Composite Fuselage - Repair and Damage Assessment Supporting Maintenance

    NASA Technical Reports Server (NTRS)

    Flynn, B. W.; Bodine, J. B.; Dopker, B.; Finn, S. R.; Griess, K. H.; Hanson, C. T.; Harris, C. G.; Nelson, K. M.; Walker, T. H.; Kennedy, T. C.; hide

    1997-01-01

    Under the NASA-sponsored contracts for Advanced Technology Composite Aircraft Structures (ATCAS) and Materials Development Omnibus Contract (MDOC), Boeing is studying the technologies associated with the application of composite materials to commercial transport fuselage structure. Included in the study is the incorporation of maintainability and repairability requirements of composite primary structure into the design. This contractor report describes activities performed to address maintenance issues in composite fuselage applications. A key aspect of the study was the development of a maintenance philosophy which included consideration of maintenance issues early in the design cycle, multiple repair options, and airline participation in design trades. Fuselage design evaluations considered trade-offs between structural weight, damage resistance/tolerance (repair frequency), and inspection burdens. Analysis methods were developed to assess structural residual strength in the presence of damage, and to evaluate repair design concepts. Repair designs were created with a focus on mechanically fastened concepts for skin/stringer structure and bonded concepts for sandwich structure. Both a large crown (skintstringer) and keel (sandwich) panel were repaired. A compression test of the keel panel indicated the demonstrated repairs recovered ultimate load capability. In conjunction with the design and manufacturing developments, inspection methods were investigated for their potential to evaluate damaged structure and verify the integrity of completed repairs.

  8. 78 FR 41046 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-09

    ... following consultation with the Committee Management Secretariat, General Services Administration, notice is... (DOE), on the Advanced Scientific Computing Research Program managed by the Office of Advanced...

  9. 75 FR 9887 - Advanced Scientific Computing Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... Baker, Office of Advanced Scientific Computing Research; SC-21/Germantown Building; U.S. Department of... meeting is to provide advice on the advanced scientific computing research program. Tentative Agenda... Information Public Reading Room; 1E-190, Forrestal Building; 1000 Independence Avenue, SW.; Washington, DC...

  10. Advanced Ground Systems Maintenance Physics Models for Diagnostics Project

    NASA Technical Reports Server (NTRS)

    Harp, Janicce Leshay

    2014-01-01

    The project will use high-fidelity physics models and simulations to simulate real-time operations of cryogenic and systems and calculate the status/health of the systems. The project enables the delivery of system health advisories to ground system operators. The capability will also be used to conduct planning and analysis of cryogenic system operations.

  11. DOE Advanced Scientific Computing Advisory Committee (ASCAC) Subcommittee Report on Scientific and Technical Information

    SciTech Connect

    Hey, Tony; Agarwal, Deborah; Borgman, Christine; Cartaro, Concetta; Crivelli, Silvia; Van Dam, Kerstin Kleese; Luce, Richard; Arjun, Shankar; Trefethen, Anne; Wade, Alex; Williams, Dean

    2015-09-04

    The Advanced Scientific Computing Advisory Committee (ASCAC) was charged to form a standing subcommittee to review the Department of Energy’s Office of Scientific and Technical Information (OSTI) and to begin by assessing the quality and effectiveness of OSTI’s recent and current products and services and to comment on its mission and future directions in the rapidly changing environment for scientific publication and data. The Committee met with OSTI staff and reviewed available products, services and other materials. This report summaries their initial findings and recommendations.

  12. DOE Advanced Scientific Computing Advisory Committee (ASCAC) Report: Exascale Computing Initiative Review

    SciTech Connect

    Reed, Daniel; Berzins, Martin; Pennington, Robert; Sarkar, Vivek; Taylor, Valerie

    2015-08-01

    On November 19, 2014, the Advanced Scientific Computing Advisory Committee (ASCAC) was charged with reviewing the Department of Energy’s conceptual design for the Exascale Computing Initiative (ECI). In particular, this included assessing whether there are significant gaps in the ECI plan or areas that need to be given priority or extra management attention. Given the breadth and depth of previous reviews of the technical challenges inherent in exascale system design and deployment, the subcommittee focused its assessment on organizational and management issues, considering technical issues only as they informed organizational or management priorities and structures. This report presents the observations and recommendations of the subcommittee.

  13. An Investigation of the Influence of Advanced Aircraft Diagnostics on the Technological Sophistication of Maintenance Personnel

    DTIC Science & Technology

    1992-09-01

    AD-A258 988 AFIT/GLM/LSM/9 2S-9 AN INVESTIGATION OF THE INFLUENCE OF ADVANCED AIRCRAFT DIAGNOSTICS ON THE TECHNOLOGICAL SOPHISTICATION OF MAINTENANCE ...DIAGNOSTICS ON THE TECHNOLOGICAL SOPHISTICATION OF MAINTENANCE PERSONNEL THESIS Presented to the Faculty of the School of Systems and Logistics of the Air...diagnostic systems will have on the maintenance worker’s technological capabilities. Four investigative questions guided the project: 1. What effect

  14. Pemetrexed in maintenance treatment of advanced non-squamous non-small-cell lung cancer.

    PubMed

    Minami, Seigo; Kijima, Takashi

    2015-01-01

    Pemetrexed, a multitargeting antifolate cytotoxic drug, plays a leading role in front-line chemotherapy for patients with advanced non-squamous non-small-cell lung cancer (NSCLC). Following its approval as second-line monotherapy for locally advanced or metastatic non-squamous NSCLC, pemetrexed has established itself as the first-line regimen in combination with cisplatin, and its powerful antitumor effects and less cumulative toxicities were then taken advantage of in the JMEN and PARAMOUNT trials, respectively, to pioneer a new treatment strategy of switch and continuation maintenance monotherapy. These developments have brought about a marked paradigm shift, and made pemetrexed indispensable in the treatment for non-squamous NSCLC. So far, only three drugs have been approved for maintenance therapy; pemetrexed both by switch and continuation maintenance, erlotinib by switch maintenance, and bevacizumab by continuation maintenance. Compared with observation alone after defined cycles of the first-line chemotherapy, subsequent pemetrexed maintenance therapy has provided significantly longer survival and infrequent severe adverse events. The cost-effectiveness of pemetrexed maintenance therapy is controversial, as well as the other two maintenance drugs, bevacizumab and erlotinib. The latest attractive attention is a combination maintenance therapy. We may have to consider epidermal growth factor receptor (EGFR) mutation status for selection of a combination pattern. A combination maintenance therapy of pemetrexed plus bevacizumab is potential for patients with wild-type EGFR status, while a EGFR tyrosine kinase inhibitor-containing combination is promising for patients with active EGFR mutation status. Pemetrexed will be a pivotal drug when a combination maintenance therapy is used in practice. For future maintenance therapy, we need to explore reliable predictive selection or exclusion markers that can predict who will really benefit from maintenance therapy.

  15. Pemetrexed in maintenance treatment of advanced non-squamous non-small-cell lung cancer

    PubMed Central

    Minami, Seigo; Kijima, Takashi

    2015-01-01

    Pemetrexed, a multitargeting antifolate cytotoxic drug, plays a leading role in front-line chemotherapy for patients with advanced non-squamous non-small-cell lung cancer (NSCLC). Following its approval as second-line monotherapy for locally advanced or metastatic non-squamous NSCLC, pemetrexed has established itself as the first-line regimen in combination with cisplatin, and its powerful antitumor effects and less cumulative toxicities were then taken advantage of in the JMEN and PARAMOUNT trials, respectively, to pioneer a new treatment strategy of switch and continuation maintenance monotherapy. These developments have brought about a marked paradigm shift, and made pemetrexed indispensable in the treatment for non-squamous NSCLC. So far, only three drugs have been approved for maintenance therapy; pemetrexed both by switch and continuation maintenance, erlotinib by switch maintenance, and bevacizumab by continuation maintenance. Compared with observation alone after defined cycles of the first-line chemotherapy, subsequent pemetrexed maintenance therapy has provided significantly longer survival and infrequent severe adverse events. The cost-effectiveness of pemetrexed maintenance therapy is controversial, as well as the other two maintenance drugs, bevacizumab and erlotinib. The latest attractive attention is a combination maintenance therapy. We may have to consider epidermal growth factor receptor (EGFR) mutation status for selection of a combination pattern. A combination maintenance therapy of pemetrexed plus bevacizumab is potential for patients with wild-type EGFR status, while a EGFR tyrosine kinase inhibitor-containing combination is promising for patients with active EGFR mutation status. Pemetrexed will be a pivotal drug when a combination maintenance therapy is used in practice. For future maintenance therapy, we need to explore reliable predictive selection or exclusion markers that can predict who will really benefit from maintenance therapy

  16. Advanced maintenance, inspection & repair technology for nuclear power plants

    SciTech Connect

    Hinton, B.M.

    1994-12-31

    Maintenance, inspection, and repair technology for nuclear power plants is outlined. The following topics are discussed: technology for reactor systems, reactor refueling bridge, fuel inspection system, fuel shuffling software, fuel reconstitution, CEA/RCCA/CRA inspection, vessel inspection capabilities, CRDM inspection and repair, reactor internals inspection and repair, stud tensioning system, stud/nut cleaning system, EDM machining technology, MI Cable systems, core exit T/C nozzle assemblies, technology for steam generators, genesis manipulator systems, ECT, UT penetrant inspections, steam generator repair and cleaning systems, technology for balance of plant, heat exchangers, piping and weld inspections, and turbogenerators.

  17. Performance of Water Recirculation Loop Maintenance Components for the Advanced Spacesuit Water Membrane Evaporator

    NASA Technical Reports Server (NTRS)

    Rector, Tony; Peyton, Barbara M.; Steele, John W.; Makinen, Janice; Bue, Grant C.; Campbell, Colin

    2014-01-01

    Water loop maintenance components to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop have undergone a comparative performance evaluation with a recirculating control loop which had no water quality maintenance. Results show that periodic water maintenance can improve performance of the SWME. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage of this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing sublimator technology. The driver for the evaluation of water recirculation maintenance components was to enhance the robustness of the SWME through the leveraging of fluid loop management lessons learned from the International Space Station (ISS). A patented bed design that was developed for a United Technologies Aerospace System military application provided a low pressure drop means for water maintenance in the SWME recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The maintenance cycle included the use of a biocide delivery component developed for the ISS to introduce a biocide in a microgravity compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

  18. Advanced solar concentrator mass production, operation, and maintenance cost assessment

    NASA Technical Reports Server (NTRS)

    Niemeyer, W. A.; Bedard, R. J.; Bell, D. M.

    1981-01-01

    The object of this assessment was to estimate the costs of the preliminary design at: production rates of 100 to 1,000,000 concentrators per year; concentrators per aperture diameters of 5, 10, 11, and 15 meters; and various receiver/power conversion package weights. The design of the cellular glass substrate Advanced Solar Concentrator is presented. The concentrator is an 11 meter diameter, two axis tracking, parabolic dish solar concentrator. The reflective surface of this design consists of inner and outer groups of mirror glass/cellular glass gores.

  19. Chemotherapy and targeted therapeutics as maintenance of response in advanced non-small cell lung cancer.

    PubMed

    Johnson, Melissa L; Patel, Jyoti D

    2014-02-01

    Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related death in the United States. Survival for patients with advanced disease remains meager with standard platinum-based doublet therapy even given initially. Improved efficacy and tolerability of third-generation chemotherapies and small-molecule inhibitors has prompted the evaluation of these agents in the maintenance setting in order to enhance current outcomes. Two separate strategies have evolved: the introduction of a non-cross-resistant drug immediately following first-line or induction chemotherapy (switch maintenance), or the continuation of the non-platinum partner initially introduced during induction (continuation maintenance). Here we review the available clinical trial data evaluating both maintenance strategies, and offer our assessment of their contemporary clinical implications and cost-effectiveness.

  20. Maintenance Cycle Extension in the IRIS Advanced Light Water Reactor Plant Design

    SciTech Connect

    Galvin, Mark R.; Todreas, Neil E.; Conway, Larry E.

    2003-09-15

    New nuclear power generation in the United States will be realized only if the economic performance can be made competitive with other methods of electrical power generation. The economic performance of a nuclear power plant can be significantly improved by increasing the time spent on-line generating electricity relative to the time spent off-line conducting maintenance and refueling. Maintenance includes planned actions (surveillances) and unplanned actions (corrective maintenance) to respond to component degradation or failure. A methodology is described that can be used to resolve, in the design phase, maintenance-related operating cycle length barriers. A primary goal was to demonstrate the applicability and utility of the methodology in the context of the International Reactor, Innovative and Secure (IRIS) design. IRIS is an advanced light water nuclear power plant that is being designed to maximize this on-line generating time by increasing the operating cycle length. This is consequently a maintenance strategy paper using the IRIS plant as the example.Potential IRIS operating cycle length maintenance-related barriers, determined by modification of an earlier operating pressurized water reactor (PWR) plant cycle length analysis to account for differences between the design of IRIS and this operating PWR, are presented. The proposed methodology to resolve these maintenance-related barriers by the design process is described. The results of applying the methodology to two potential IRIS cycle length barriers, relief valve testing and emergency heat removal system testing, are presented.

  1. An Advanced Tool for Control System Design and Maintenance

    SciTech Connect

    Storm, Joachim; Lohmann, Heinz

    2006-07-01

    The detailed engineering for control systems is usually supported by CAD Tools creating the relevant logic diagrams including software parameters and signal cross references. However at this stage of the design an early V and V process for checking out the functional correctness of the design is not available. The article describes the scope and capabilities of an advanced control system design tool which has the embedded capability of a stand-alone simulation of complex logic structures. The tool provides the following features for constructing logic diagrams for control systems: - Drag and Drop construction of logic diagrams using a predefined symbol sets; - Cross reference facility; - Data extraction facility; - Stand-alone simulation for Logic Diagrams featuring: On the fly changes, signal line animation, value boxes and mini trends etc. - Creation and on-line animation of Compound Objects (Handler); - Code Generation Facility for Simulation; - Code Generation Facility for several control systems. The results of the integrated simulation based V and V process can be used further for initial control system configuration and life cycle management as well as for Engineering Test Bed applications and finally in full Scope Replica Simulators for Operator Training. (authors)

  2. Maintenance Chemotherapy for Advanced Non–Small-Cell Lung Cancer: New Life for an Old Idea

    PubMed Central

    Gerber, David E.; Schiller, Joan H.

    2013-01-01

    Although well established for the treatment of certain hematologic malignancies, maintenance therapy has only recently become a treatment paradigm for advanced non–small-cell lung cancer. Maintenance therapy, which is designed to prolong a clinically favorable state after completion of a predefined number of induction chemotherapy cycles, has two principal paradigms. Continuation maintenance therapy entails the ongoing administration of a component of the initial chemotherapy regimen, generally the nonplatinum cytotoxic drug or a molecular targeted agent. With switch maintenance (also known as sequential therapy), a new and potentially non–cross-resistant agent is introduced immediately on completion of first-line chemotherapy. Potential rationales for maintenance therapy include increased exposure to effective therapies, decreasing chemotherapy resistance, optimizing efficacy of chemotherapeutic agents, antiangiogenic effects, and altering antitumor immunity. To date, switch maintenance therapy strategies with pemetrexed and erlotinib have demonstrated improved overall survival, resulting in US Food and Drug Administration approval for this indication. Recently, continuation maintenance with pemetrexed was found to prolong overall survival as well. Factors predicting benefit from maintenance chemotherapy include the degree of response to first-line therapy, performance status, the likelihood of receiving further therapy at the time of progression, and tumor histology and molecular characteristics. Several aspects of maintenance therapy have raised considerable debate in the thoracic oncology community, including clinical trial end points, the prevalence of second-line chemotherapy administration, the role of treatment-free intervals, quality of life, economic considerations, and whether progression-free survival is a worthy therapeutic goal in this disease setting. PMID:23401441

  3. Performance of Water Recirculation Loop Maintenance Components for the Advanced Spacesuit Water Membrane Evaporator

    NASA Technical Reports Server (NTRS)

    Rector, Tony; Peyton, Barbara M.; Steele, John W.; Makinen, Janice; Bue, Grant C.; Campbell, Colin

    2014-01-01

    Water loop maintenance components to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop have undergone a comparative performance evaluation with a second SWME water recirculation loop with no water quality maintenance. Results show the benefits of periodic water maintenance. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the evaluation of water recirculation maintenance components was to further enhance this advantage through the leveraging of fluid loop management lessons learned from the International Space Station (ISS). A bed design that was developed for a UTAS military application, and considered for a potential ISS application with the Urine Processor Assembly, provided a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The maintenance cycle included the use of a biocide delivery component developed for ISS to introduce a biocide in a microgravity compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

  4. Present Status and Future Growth of Advanced Maintenance Technology and Strategy in US Manufacturing

    PubMed Central

    Jin, Xiaoning; Weiss, Brian A.; Siegel, David; Lee, Jay

    2016-01-01

    The goals of this paper are to 1) examine the current practices of diagnostics, prognostics, and maintenance employed by United States (U.S.) manufacturers to achieve productivity and quality targets and 2) to understand the present level of maintenance technologies and strategies that are being incorporated into these practices. A study is performed to contrast the impact of various industry-specific factors on the effectiveness and profitability of the implementation of prognostics and health management technologies, and maintenance strategies using both surveys and case studies on a sample of U.S. manufacturing firms ranging from small to mid-sized enterprises (SMEs) to large-sized manufacturing enterprises in various industries. The results obtained provide important insights on the different impacts of specific factors on the successful adoption of these technologies between SMEs and large manufacturing enterprises. The varying degrees of success with respect to current maintenance programs highlight the opportunity for larger manufacturers to improve maintenance practices and consider the use of advanced prognostics and health management (PHM) technology. This paper also provides the existing gaps, barriers, future trends, and roadmaps for manufacturing PHM technology and maintenance strategy. PMID:28058173

  5. Present Status and Future Growth of Advanced Maintenance Technology and Strategy in US Manufacturing.

    PubMed

    Jin, Xiaoning; Weiss, Brian A; Siegel, David; Lee, Jay

    2016-01-01

    The goals of this paper are to 1) examine the current practices of diagnostics, prognostics, and maintenance employed by United States (U.S.) manufacturers to achieve productivity and quality targets and 2) to understand the present level of maintenance technologies and strategies that are being incorporated into these practices. A study is performed to contrast the impact of various industry-specific factors on the effectiveness and profitability of the implementation of prognostics and health management technologies, and maintenance strategies using both surveys and case studies on a sample of U.S. manufacturing firms ranging from small to mid-sized enterprises (SMEs) to large-sized manufacturing enterprises in various industries. The results obtained provide important insights on the different impacts of specific factors on the successful adoption of these technologies between SMEs and large manufacturing enterprises. The varying degrees of success with respect to current maintenance programs highlight the opportunity for larger manufacturers to improve maintenance practices and consider the use of advanced prognostics and health management (PHM) technology. This paper also provides the existing gaps, barriers, future trends, and roadmaps for manufacturing PHM technology and maintenance strategy.

  6. Research requirements for development of advanced-technology helicopter transmissions. [reduction of maintenance costs

    NASA Technical Reports Server (NTRS)

    Lemanski, A. J.

    1976-01-01

    Helicopter drive-system technology which would result in the largest benefit in direct maintenance cost when applied to civil helicopters in the 1980 timeframe was developed. A prototype baseline drive system based on 1975 technology provided the basis for comparison against the proposed advanced technology in order to determine the potential for each area recommended for improvement. A specific design example of an advanced-technology main transmission is presented to define improvements for maintainability, weight, producibility, reliability, noise, vibration, and diagnostics. Projections of the technology achievable in the 1980 timeframe are presented. Based on this data, the technologies with the highest payoff (lowest direct maintenance cost) for civil-helicopter drive systems are identified.

  7. An application of oscillation-damped motion for suspended payloads to the advanced integrated maintenance system

    SciTech Connect

    Noakes, M.W. ); Petterson, B.J.; Werner, J.C. )

    1990-06-01

    The transportation of objects using overhead cranes can induce pendular motion of the object, which usually must be damped or allowed to decay before the next process can take place. Recent work at Sandia National Laboratories has shown that oscillation-damped transport and swing-free stops are possible by properly programming the acceleration of the transporting crane. Initial studies have been completed using a CIMCORP XR6100 gantry robot. The Advanced Integrated Maintenance System (AIMS) is an engineering and operations test bed developed for remote maintenance and handling studies within the Consolidated Fuel Reprocessing Program (CFRP) at Oak Ridge National Laboratory. The goal of CFRP has been to advanced the technology of in-cell systems planned for future nuclear fuel cycle facilities. The AIMS provides the capabilities to examine the needs and constraints necessary for hot-cell remote maintenance and includes a force-reflecting master/slave teleoperator and overhead transporter system. The associated control system provides a flexible programming environment conducive to controls experimentation. This paper reviews the theory associated with oscillation-damped trajectories for simply suspended objects and describes a specific implementation of the oscillation damping methods for the AIMS transporter. Hardware and software requirements and constraints for proper operation are discussed.

  8. How Project Management Tools Aid in Association to Advance Collegiate Schools of Business (AACSB) International Maintenance of Accreditation

    ERIC Educational Resources Information Center

    Cann, Cynthia W.; Brumagim, Alan L.

    2008-01-01

    The authors present the case of one business college's use of project management techniques as tools for accomplishing Association to Advance Collegiate Schools of Business (AACSB) International maintenance of accreditation. Using these techniques provides an efficient and effective method of organizing maintenance efforts. In addition, using…

  9. How Project Management Tools Aid in Association to Advance Collegiate Schools of Business (AACSB) International Maintenance of Accreditation

    ERIC Educational Resources Information Center

    Cann, Cynthia W.; Brumagim, Alan L.

    2008-01-01

    The authors present the case of one business college's use of project management techniques as tools for accomplishing Association to Advance Collegiate Schools of Business (AACSB) International maintenance of accreditation. Using these techniques provides an efficient and effective method of organizing maintenance efforts. In addition, using…

  10. A Future With The United States Air Force Advanced Maintenance And Munitions Operations School: Securing Strategic Agility Through 2036

    DTIC Science & Technology

    2016-06-01

    the USAF Advanced Maintenance and Munitions Operations School (AMMOS). For 12 years AMMOS’ Combat Support Course (CSC) provided the Air Force’s...of AMMOS: 2003-2013 In June, 2003, the Air Expeditionary Force Logistics School graduated its inaugural class. Later that year , Logistics...in 2004 the school was reduced to 14 weeks and renamed the USAF Advanced Maintenance and Munitions Officer School (AMMOS).30 That same year , the

  11. Maintenance therapy in advanced non-small cell lung cancer: evolution, tolerability and outcomes

    PubMed Central

    Coate, Linda E.; Shepherd, Frances A.

    2011-01-01

    Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the industrialized world. Despite significant progress in early stage disease, survival rates for advanced disease remain low. Maintenance therapy is a treatment strategy that has been investigated extensively in NSCLC and has been the subject of considerable recent debate. Options for maintenance include continuing the initial combination chemotherapy regimen, continuing only single agent chemotherapy (‘continuation maintenance’) or introducing a new agent (‘switch’ maintenance therapy). Therapies that have been studied in this setting in randomized trials to date include chemotherapy, molecularly targeted agents and immunotherapy approaches. Following the development of multiple new agents that show activity in NSCLC, and have a tolerable side-effect profile, there has been increasing interest in utilizing them to maintain response to initial therapy after treatment with platinum-based doublets. Despite considerable controversy, it has become an acceptable treatment paradigm. Here, we briefly outline the evolution of this treatment paradigm and examine which subgroups of patients are most likely to benefit. PMID:21904577

  12. Advanced training of specialists in area of fiber-optic communication lines maintenance

    NASA Astrophysics Data System (ADS)

    Andreev, Vladimir A.; Voronkov, Andrey A.; Bukashkin, Sergey A.; Buzova, Maria A.

    2017-04-01

    The paper considers the concept of fiber-optic communication lines (FOCL) maintenance. Performance criterion of FOCL technical maintenance was proposed. For the first time the algorithm for evaluation of the FOCL maintenance efficiency at telecommunication specialists training was applied.

  13. Critical appraisal of rituximab in the maintenance treatment of advanced follicular lymphoma

    PubMed Central

    Aguiar-Bujanda, David; Blanco-Sánchez, María Jesús; Hernández-Sosa, María; Galván-Ruíz, Saray; Hernández-Sarmiento, Samuel

    2015-01-01

    Rituximab is an IgG1, chimeric monoclonal antibody specifically designed to recognize the CD20 antigen expressed on the surface of normal and malignant B-lymphocytes, from the B-cell precursor to the mature B-cells of the germinal center, and by most neoplasms derived from B-cells. After 2 decades of use, rituximab is firmly positioned in the treatment of follicular lymphoma (FL), both in the front line and in the relapsing disease, improving previous results by including it in classical chemotherapy regimens. However, the pharmacology of rituximab continues to generate controversial issues especially regarding the mechanisms of action in vivo. The contribution of rituximab as a maintenance treatment in FL has been significant progress in the management of this disease without an increase in side effects or a decrease in the quality of life of patients. With the widespread use of rituximab, there are new security alerts and side effects not previously detected in the pivotal trials that clinicians should learn to recognize and manage. In this article, we will review the pharmacokinetics and pharmacodynamics of rituximab, the management issues in the treatment of advanced FL focusing on maintenance rituximab, its long-term efficacy and safety profile, and its effect on the quality of life. PMID:26604821

  14. Advanced spent fuel conditioning process (ACP) progress with respect to remote operation and maintenance

    SciTech Connect

    Lee, Hyo Jik; Lee, Jong Kwang; Park, Byung Suk; Yoon, Ji Sup

    2007-07-01

    Korea Atomic Energy Research Institute (KAERI) has been developing an Advanced Spent Fuel Conditioning Process (ACP) to reduce the volume of spent fuel, and the construction of the ACP facility (ACPF) for a demonstration of its technical feasibility has been completed. In 2006 two inactive demonstrations were performed with simulated fuels in the ACPF. Accompanied by process equipment performance tests, its remote operability and maintainability were also tested during that time. Procedures for remote operation tasks are well addressed in this study and evaluated thoroughly. Also, remote maintenance and repair tasks are addressed regarding some important modules with a high priority order. The above remote handling test's results provided a lot of information such as items to be revised to improve the efficiency of the remote handling tasks. This paper deals with the current status of ACP and the progress of remote handling of ACPF. (authors)

  15. An application of oscillation damped motion for suspended payloads to the advanced integrated maintenance system

    SciTech Connect

    Noakes, M.W. ); Petterson, B.J.; Werner, J.C. )

    1990-01-01

    Transportation of objects using overhead cranes can induce pendulum motion of the object, which usually must be damped or allowed to decay before the next process can take place. Recent work at Sandia National Laboratories (SNL) has shown that oscillation damped transport and swing-free stops are possible by properly programming the acceleration of the transporting crane. This paper reviews the theory associated with oscillation-damped trajectories for simply suspended objects and describes a specific, full-scale implementation of the damped oscillation methods for the Oak Ridge National Laboratory (ORNL) Advanced Integrated Maintenance System (AIMS). Hardware and software requirements and constraints for proper operation are discussed. Finally, test results and lessons learned are presented. 5 refs., 4 figs.

  16. Nuclear Systems Enhanced Performance Program, Maintenance Cycle Extension in Advanced Light Water Reactor Design

    SciTech Connect

    Professor Neill Todreas

    2001-10-01

    A renewed interest in new nuclear power generation in the US has spurred interest in developing advanced reactors with features which will address the public's concerns regarding nuclear generation. However, it is economic performance which will dictate whether any new orders for these plants will materialize. Economic performance is, to a great extent, improved by maximizing the time that the plant is on-line generating electricity relative to the time spent off-line conducting maintenance and refueling. Indeed, the strategy for the advanced light water reactor plant IRIS (International Reactor, Innovative and Secure) is to utilize an eight year operating cycle. This report describes a formalized strategy to address, during the design phase, the maintenance-related barriers to an extended operating cycle. The top-level objective of this investigation was to develop a methodology for injecting component and system maintainability issues into the reactor plant design process to overcome these barriers. A primary goal was to demonstrate the applicability and utility of the methodology in the context of the IRIS design. The first step in meeting the top-level objective was to determine the types of operating cycle length barriers that the IRIS design team is likely to face. Evaluation of previously identified regulatory and investment protection surveillance program barriers preventing a candidate operating PWR from achieving an extended (48 month) cycle was conducted in the context of the IRIS design. From this analysis, 54 known IRIS operating cycle length barriers were identified. The resolution methodology was applied to each of these barriers to generate design solution alternatives for consideration in the IRIS design. The methodology developed has been demonstrated to narrow the design space to feasible design solutions which enable a desired operating cycle length, yet is general enough to have broad applicability. Feedback from the IRIS design team indicates

  17. Budget impact of erlotinib for maintenance therapy in advanced non-small cell lung cancer.

    PubMed

    Carlson, Josh J; Wong, William B; Veenstra, David L; Reyes, Carolina

    2011-01-01

    Assess the budgetary impact of adding erlotinib for maintenance therapy (MTx) in advanced non-small cell lung cancer (NSCLC) from a US health plan perspective. A budget impact model was developed to analyze the costs (drug, administration, adverse events) associated with adding erlotinib MTx to a hypothetical 500,000 member US health plan. Treatment durations and dosing were derived from randomized controlled trials, FDA labeling, and National Comprehensive Cancer Network guidelines. Treatment patterns and assumptions were based on market research data, the SEER registry, and published literature. Cost data were obtained from Centers for Medicare and Medicaid Services payment rates and a drug pricing database. Sensitivity analyses were conducted to assess uncertainty. Overall health plan expenditures increased by $0.010 per member per month (PMPM). The main driver of additional cost was the erlotinib drug cost (∼$66,000) with the administration ($464) and side-effect ($47) costs being relatively modest. One-way sensitivity analyses showed that the results were most sensitive to the proportion of members receiving MTx; however, the PMPM did not exceed $0.013. The overall budget impact to a health plan of expanding the use of erlotinib from the 2nd/3rd-line advanced NSCLC setting to include the maintenance setting was relatively small. This was primarily due to the proportion of patients who would receive erlotinib MTx, the low cost of side-effects and minimal cost of drug administration. Additional research may be warranted to estimate the relative clinical and economic impacts of erlotinib MTx versus alternative MTx treatments.

  18. Advance Directives and End-of-Life Care among Nursing Home Residents Receiving Maintenance Dialysis.

    PubMed

    Kurella Tamura, Manjula; Montez-Rath, Maria E; Hall, Yoshio N; Katz, Ronit; O'Hare, Ann M

    2017-03-07

    Little is known about the relation between the content of advance directives and downstream treatment decisions among patients receiving maintenance dialysis. In this study, we determined the prevalence of advance directives specifying treatment limitations and/or surrogate decision-makers in the last year of life and their association with end-of-life care among nursing home residents. Using national data from 2006 to 2007, we compared the content of advance directives among 30,716 nursing home residents receiving dialysis to 30,825 nursing home residents with other serious illnesses during the year before death. Among patients receiving dialysis, we linked the content of advance directives to Medicare claims to ascertain site of death and treatment intensity in the last month of life. In the last year of life, 36% of nursing home residents receiving dialysis had a treatment-limiting directive, 22% had a surrogate decision-maker, and 13% had both in adjusted analyses. These estimates were 13%-27%, 5%-11%, and 6%-13% lower, respectively, than for decedents with other serious illnesses. For patients receiving dialysis who had both a treatment-limiting directive and surrogate decision-maker, the adjusted frequency of hospitalization, intensive care unit admission, intensive procedures, and inpatient death were lower by 13%, 17%, 13%, and 14%, respectively, and hospice use and dialysis discontinuation were 5% and 7% higher compared with patients receiving dialysis lacking both components. Among nursing home residents receiving dialysis, treatment-limiting directives and surrogates were associated with fewer intensive interventions and inpatient deaths, but were in place much less often than for nursing home residents with other serious illnesses. Copyright © 2017 by the American Society of Nephrology.

  19. Advanced Visual and Instruction Systems for Maintenance Support (AVIS-MS)

    DTIC Science & Technology

    2006-12-01

    TERMS Maintenance Aides, Augmented Reality , Virtual Reality, Instruction Authoring 1ý. SECURITY CLASSIFICATION OF: 17. LIMITATION 18. NUMBER 19a. NAME...19 5.1 Surveys of Augmented Reality .............................................. 20 5.2 Applications in Maintenance...This project involved the investigation of Augmented Reality (AR) devices for maintenance instruction presentation for training and job aids. We

  20. Advanced Ground Systems Maintenance Functional Fault Models For Fault Isolation Project

    NASA Technical Reports Server (NTRS)

    Perotti, Jose M. (Compiler)

    2014-01-01

    This project implements functional fault models (FFM) to automate the isolation of failures during ground systems operations. FFMs will also be used to recommend sensor placement to improve fault isolation capabilities. The project enables the delivery of system health advisories to ground system operators.

  1. Performance of a Water Recirculation Loop Maintenance Device and Process for the Advanced Spacesuit Water Membrane Evaporator

    NASA Technical Reports Server (NTRS)

    Rector, Tony; Steele, John W.; Bue, Grant C.; Campbell, Colin; Makinen, Janice

    2012-01-01

    A water loop maintenance device and process to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop has been undergoing a performance evaluation. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the water recirculation maintenance device and process is to further enhance this advantage through the leveraging of fluid loop management lessons-learned from the International Space Station (ISS). A bed design that was developed for a Hamilton Sundstrand military application, and considered for a potential ISS application with the Urine Processor Assembly, provides a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The maintenance process further leverages a sorbent developed for ISS that introduces a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware. This

  2. Maintenance or non-maintenance therapy in the treatment of advanced non-small cell lung cancer: that is the question.

    PubMed

    Galetta, D; Rossi, A; Pisconti, S; Millaku, A; Colucci, G

    2010-11-01

    Lung cancer is the most common cancer worldwide with non-small cell lung cancer (NSCLC), including squamous carcinoma, adenocarcinoma and large cell carcinoma, accounting for about 85% of all lung cancer types with most of the patients presenting with advanced disease at the time of diagnosis. In this setting first-line platinum-based chemotherapy for no more than 4-6 cycles are recommended. After these cycles of treatment, non-progressing patients enter in the so called "watch and wait" period in which no further therapy is administered until there is disease progression. In order to improve the advanced NSCLC outcomes, the efficacy of further treatment in the "watch and wait" period was investigated. This is the "maintenance therapy". Recently, the results coming from randomized phase III trials investigating two new agents, pemetrexed and erlotinib, in this setting led to their registration for maintenance therapy. Here, we report and discuss these results. Copyright © 2010 Elsevier Ltd. All rights reserved.

  3. Colleges of Advanced Education, 1967-69; A First Report of the Commonwealth Advisory Committee on Advanced Education.

    ERIC Educational Resources Information Center

    Commonwealth Advisory Committee on Advanced Education, Canberra (Australia).

    This document is an English-language abstract (approximately 1,500 words) of a report by the "Wark Committee", established to promote the balanced development of higher education outside the universities and teacher training colleges. The aim of this development is a new type of institution, the college of advanced education. The states…

  4. Statement of Aaron Cohen, Director, Research and Engineering, Johnson Space Center and Chairman, Space Station Advanced Technology Advisory Committee, National Aeronautics and Space Administration, before the Subcommittee on Science, Technology, and Space, Committee on Commerce, Science, and Transportation, United States Senate

    NASA Technical Reports Server (NTRS)

    Cohen, A.

    1985-01-01

    The activities of NASA's Space Station Advanced Technology Advisory Committee is discussed. Advanced Technology Advisory Committee (ATAC) activities over the last year are reviewed in preparation of the report to Congress on the potential for advancing automation and robotics technology for the space station and for the U.S. economy.

  5. Automation and robotics for the Space Station - The influence of the Advanced Technology Advisory Committee

    NASA Technical Reports Server (NTRS)

    Nunamaker, Robert R.; Willshire, Kelli F.

    1988-01-01

    The reports of a committee established by Congress to identify specific systems of the Space Station which would advance automation and robotics technologies are reviewed. The history of the committee, its relation to NASA, and the reports which it has released are discussed. The committee's reports recommend the widespread use of automation and robotics for the Space Station, a program for technology development and transfer between industries and research and development communities, and the planned use of robots to service and repair satellites and their payloads which are accessible from the Space Station.

  6. Maintenance Peginterferon Therapy and Other Factors Associated with Hepatocellular Carcinoma in Patients with Advanced Hepatitis C

    PubMed Central

    Lok, Anna S.; Everhart, James E.; Wright, Elizabeth C.; Di Bisceglie, Adrian M.; Kim, Hae-Young; Sterling, Richard K.; Everson, Gregory T.; Lindsay, Karen L.; Lee, William M.; Bonkovsky, Herbert L.; Dienstag, Jules L.; Ghany, Marc G.; Morishima, Chihiro; Morgan, Timothy R.

    2010-01-01

    Background & Aims Interferon reportedly decreases the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C. The Hepatitis C anti-viral long-term treatment against cirrhosis (HALT-C) trial showed that 4 years of maintenance therapy with peginterferon does not reduce liver disease progression. We investigated whether peginterferon decreases the incidence of HCC in the HALT-C cohort over a longer post-treatment follow-up period. Methods The study included 1,048 patients with chronic Hepatitis C (Ishak fibrosis scores ≥3) who did not have a sustained virological response (SVR) to therapy. They were randomly assigned to groups given a half-dose of peginterferon or no treatment (controls) for 3.5 years and followed for a median 6.1 (maximum 8.7) years. Results Eighty-eight patients developed HCC (68 definite, 20 presumed): 37/515 that were given peginterferon (7.2%) and 51/533 controls (9.6%; P=0.24). There was a significantly lower incidence of HCC among patients given peginterferon therapy who had cirrhosis, but not fibrosis, based on analysis of baseline biopsy samples. After 7 years, the cumulative incidences of HCC in treated and control patients with cirrhosis were 7.8% and 24.2%, respectively (hazard ratio [HR]=0.45; 95% confidence interval [CI]: 0.24–0.83); in treated and control patients with fibrosis they were 8.3% and 6.8%, respectively (HR=1.44; 95% CI: 0.77–2.69). Treated patients with a ≥2-point decrease in the histologic activity index, based on a follow-up biopsy, had a lower incidence of HCC than those with unchanged or increased scores (2.9% vs. 9.4%; P=0.03). Conclusions Extended analysis of the HALT-C cohort showed that long-term peginterferon therapy does not reduce the incidence of HCC among patients with advanced hepatitis C who did not achieve SVRs. Patients with cirrhosis who received peginterferon treatment had a lower risk for HCC than controls. PMID:21129375

  7. Meta-analysis of first-line therapies with maintenance regimens for advanced non-small-cell lung cancer (NSCLC) in molecularly and clinically selected populations.

    PubMed

    Tan, Pui San; Bilger, Marcel; de Lima Lopes, Gilberto; Acharyya, Sanchalika; Haaland, Benjamin

    2017-08-01

    Evidence has suggested survival benefits of maintenance for advanced NSCLC patients not progressing after first-line chemotherapy. Additionally, particular first-line targeted therapies have shown survival improvements in selected populations. Optimal first-line and maintenance therapies remain unclear. Here, currently available evidence was synthesized to elucidate optimal first-line and maintenance therapy within patient groups. Literature was searched for randomized trials evaluating first-line and maintenance regimens in advanced NSCLC patients. Bayesian network meta-analysis was performed within molecularly and clinically selected groups. The primary outcome was combined clinically meaningful OS and PFS benefits. A total of 87 records on 56 trials evaluating first-line treatments with maintenance were included. Results showed combined clinically meaningful OS and PFS benefits with particular first-line with maintenance treatments, (1) first-line intercalated chemotherapy+erlotinib, maintenance erlotinib in patients with EGFR mutations, (2) first-line afatinib, maintenance afatinib in patients with EGFR deletion 19, (3) first-line chemotherapy + bevacizumab, maintenance bevacizumab in EGFR wild-type patients, (4) chemotherapy+conatumumab, maintenance conatumumab in patients with squamous histology, (5) chemotherapy+cetuximab, maintenance cetuximab or chemotherapy + necitumumab, maintenance necitumumab in EGFR FISH-positive patients with squamous histology, and (6) first-line chemotherapy+bevacizumab, maintenance bevacizumab or first-line sequential chemotherapy+gefitinib, maintenance gefitinib in patients clinically enriched for EGFR mutations with nonsquamous histology. No treatment showed combined clinically meaningful OS and PFS benefits in patients with EGFR L858R or nonsquamous histology. Particular first-line with maintenance treatments show meaningful OS and PFS benefits in patients selected by EGFR mutation or histology. Further research is needed

  8. DOE Advanced Scientific Computing Advisory Subcommittee (ASCAC) Report: Top Ten Exascale Research Challenges

    SciTech Connect

    Lucas, Robert; Ang, James; Bergman, Keren; Borkar, Shekhar; Carlson, William; Carrington, Laura; Chiu, George; Colwell, Robert; Dally, William; Dongarra, Jack; Geist, Al; Haring, Rud; Hittinger, Jeffrey; Hoisie, Adolfy; Klein, Dean Micron; Kogge, Peter; Lethin, Richard; Sarkar, Vivek; Schreiber, Robert; Shalf, John; Sterling, Thomas; Stevens, Rick; Bashor, Jon; Brightwell, Ron; Coteus, Paul; Debenedictus, Erik; Hiller, Jon; Kim, K. H.; Langston, Harper; Murphy, Richard Micron; Webster, Clayton; Wild, Stefan; Grider, Gary; Ross, Rob; Leyffer, Sven; Laros III, James

    2014-02-10

    Exascale computing systems are essential for the scientific fields that will transform the 21st century global economy, including energy, biotechnology, nanotechnology, and materials science. Progress in these fields is predicated on the ability to perform advanced scientific and engineering simulations, and analyze the deluge of data. On July 29, 2013, ASCAC was charged by Patricia Dehmer, the Acting Director of the Office of Science, to assemble a subcommittee to provide advice on exascale computing. This subcommittee was directed to return a list of no more than ten technical approaches (hardware and software) that will enable the development of a system that achieves the Department's goals for exascale computing. Numerous reports over the past few years have documented the technical challenges and the non¬-viability of simply scaling existing computer designs to reach exascale. The technical challenges revolve around energy consumption, memory performance, resilience, extreme concurrency, and big data. Drawing from these reports and more recent experience, this ASCAC subcommittee has identified the top ten computing technology advancements that are critical to making a capable, economically viable, exascale system.

  9. Recent advances in post autologous transplantation maintenance therapies in B-cell non-Hodgkin lymphomas.

    PubMed

    Epperla, Narendranath; Fenske, Timothy S; Hari, Parameswaran N; Hamadani, Mehdi

    2015-09-24

    Lymphomas constitute the second most common indication for high dose therapy (HDT) followed by autologous hematopoietic cell transplantation (auto-HCT). The intent of administering HDT in these heterogeneous disorders varies from cure (e.g., in relapsed aggressive lymphomas) to disease control (e.g., most indolent lymphomas). Regardless of the underlying histology or remission status at transplantation, disease relapse remains the number one cause of post auto-HCT therapy failure and mortality. The last decade has seen a proliferation of clinical studies looking at prevention of post auto-HCT therapy failure with various maintenance strategies. The benefit of such therapies is in turn dependent on disease histology and timing of transplantation. In relapsed, chemosensitive diffuse large B-cell lymphoma (DLBCL), although post auto-HCT maintenance rituximab seems to be safe and feasible, it does not provide improved survival outcomes and is not recommended. The preliminary results with anti- programmed death -1 (PD-1) antibody therapy as post auto-HCT maintenance in DLBCL is promising but requires randomized validation. Similarly in follicular lymphoma, maintenance therapies including rituximab following auto-HCT should be considered investigational and offered only on a clinical trial. Rituximab maintenance results in improved progression-free survival but has not yet shown to improve overall survival in mantle cell lymphoma (MCL), but given the poor prognosis with post auto-HCT failure in MCL, maintenance rituximab can be considered on a case-by-case basis. Ongoing trials evaluating the efficacy of post auto-HCT maintenance with novel compounds (e.g., immunomodulators, PD-1 inhibitors, proteasome inhibitors and bruton's tyrosine kinase inhibitors) will likely change the practice landscape in the near future for B cell non-Hodgkin lymphomas patients following HDT and auto-HCT.

  10. Recent advances in post autologous transplantation maintenance therapies in B-cell non-Hodgkin lymphomas

    PubMed Central

    Epperla, Narendranath; Fenske, Timothy S; Hari, Parameswaran N; Hamadani, Mehdi

    2015-01-01

    Lymphomas constitute the second most common indication for high dose therapy (HDT) followed by autologous hematopoietic cell transplantation (auto-HCT). The intent of administering HDT in these heterogeneous disorders varies from cure (e.g., in relapsed aggressive lymphomas) to disease control (e.g., most indolent lymphomas). Regardless of the underlying histology or remission status at transplantation, disease relapse remains the number one cause of post auto-HCT therapy failure and mortality. The last decade has seen a proliferation of clinical studies looking at prevention of post auto-HCT therapy failure with various maintenance strategies. The benefit of such therapies is in turn dependent on disease histology and timing of transplantation. In relapsed, chemosensitive diffuse large B-cell lymphoma (DLBCL), although post auto-HCT maintenance rituximab seems to be safe and feasible, it does not provide improved survival outcomes and is not recommended. The preliminary results with anti- programmed death -1 (PD-1) antibody therapy as post auto-HCT maintenance in DLBCL is promising but requires randomized validation. Similarly in follicular lymphoma, maintenance therapies including rituximab following auto-HCT should be considered investigational and offered only on a clinical trial. Rituximab maintenance results in improved progression-free survival but has not yet shown to improve overall survival in mantle cell lymphoma (MCL), but given the poor prognosis with post auto-HCT failure in MCL, maintenance rituximab can be considered on a case-by-case basis. Ongoing trials evaluating the efficacy of post auto-HCT maintenance with novel compounds (e.g., immunomodulators, PD-1 inhibitors, proteasome inhibitors and bruton’s tyrosine kinase inhibitors) will likely change the practice landscape in the near future for B cell non-Hodgkin lymphomas patients following HDT and auto-HCT. PMID:26421260

  11. Design and Evaluation of a Water Recirculation Loop Maintenance Device for the Advanced Spacesuit Water Membrane Evaporator

    NASA Technical Reports Server (NTRS)

    Steele, John W.; Rector, Tony; Bue, Grant C.; Campbell, Colin; Makinen, Janice

    2012-01-01

    A dual-bed device to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop has been designed and is undergoing testing. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing sublimator technology. The driver for the development of a water recirculation maintenance device is to further enhance this advantage through the leveraging of fluid loop management lessons learned from the International Space Station (ISS). A bed design that was developed for a Hamilton Sundstrand military application, and considered for a potential ISS application with the Urine Processor Assembly, provides a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high-capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit Transport Water Loop. The bed design further leverages a sorbent developed for the ISS that introduces a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System. The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of crewed spaceflight Environmental Control and Life Support System hardware.

  12. Design and Evaluation of a Water Recirculation Loop Maintenance Device for the Advanced Spacesuit Water Membrane Evaporator

    NASA Technical Reports Server (NTRS)

    Steele, John W.; Rector, Tony; Bue, Grant C.; Campbell, Colin; Makinen, Janice

    2011-01-01

    A dual-bed device to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop has been designed and is undergoing testing. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the development of a water recirculation maintenance device is to further enhance this advantage through the leveraging of fluid loop management lessons-learned from the International Space Station (ISS). A bed design that was developed for a Hamilton Sundstrand military application, and considered for a potential ISS application with the Urine Processor Assembly, provides a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The bed design further leverages a sorbent developed for ISS that introduces a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a clear demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

  13. Performance of a Water Recirculation Loop Maintenance Device and Process for the Advanced Spacesuit Water Membrane Evaporator

    NASA Technical Reports Server (NTRS)

    Steele, John W.; Rector, Tony; Bue, Grant C.; Campbell, Colin; Makinen, Janice

    2013-01-01

    A dual-bed device to maintain the water quality of the Advanced Spacesuit Water Membrane Evaporation (SWME) water recirculation loop has been designed and is undergoing testing. The SWME is a heat rejection device under development at the NASA Johnson Space Center to perform thermal control for advanced spacesuits. One advantage to this technology is the potential for a significantly greater degree of tolerance to contamination when compared to the existing Sublimator technology. The driver for the development of a water recirculation maintenance device is to further enhance this advantage through the leveraging of fluid loop management lessons-learned from the International Space Station (ISS). A bed design that was developed for a Hamilton Sundstrand military application, and considered for a potential ISS application with the Urine Processor Assembly, provides a low pressure drop means for water maintenance in a recirculation loop. The bed design is coupled with high capacity ion exchange resins, organic adsorbents, and a cyclic methodology developed for the Extravehicular Mobility Unit (EMU) Transport Water loop. The bed design further leverages a sorbent developed for ISS that introduces a biocide in a microgravity-compatible manner for the Internal Active Thermal Control System (IATCS). The leveraging of these water maintenance technologies to the SWME recirculation loop is a unique demonstration of applying the valuable lessons learned on the ISS to the next generation of manned spaceflight Environmental Control and Life Support System (ECLSS) hardware.

  14. Hagerstown Junior College Advisory Committee Handbook.

    ERIC Educational Resources Information Center

    Hagerstown Junior Coll., MD.

    The use of advisory committees in occupational education is a natural and desirable extension of lay participation in education and an efficient and logical way of keeping programs current. At Hagerstown Junior College (HJC), the primary functions of an advisory committee are to provide advice and counsel regarding the development, maintenance,…

  15. Advanced Planning and Scheduling in the United States Air Force Depot-Level Maintenance

    DTIC Science & Technology

    2002-03-01

    parameters The Air Logistic Center (ALC) Environment Within the Air Force, the management of high-cost inventory items (those that would be considered...of an inventory management system to more effectively support the determination of material requirements for maintenance and repair. Research...the problem, simulation has been determined to be superior to other tools. A comparison of the competing APS inventory management models, based on the

  16. 77 FR 5090 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ... Affairs (VA) gives notice under Public Law 92-463 (Federal Advisory Committee Act) that the Advisory... on the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities. The...

  17. 76 FR 11855 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-03

    ... Affairs (VA) gives notice under Public Law 92-463 (Federal Advisory Committee Act) that the Advisory... the Committee is to advise the Secretary of Veterans Affairs on the maintenance and periodic...

  18. 75 FR 25925 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ... Affairs (VA) gives notice under Public Law 92-463 (Federal Advisory Committee Act) that the Advisory... Veterans Affairs on the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities...

  19. 75 FR 15497 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... Affairs (VA) gives notice under Public Law 92-463 (Federal Advisory Committee Act) that the Advisory... Veterans Affairs on the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities...

  20. 76 FR 64429 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... Affairs (VA) gives notice under Public Law 92-463 (Federal Advisory Committee Act) that the Advisory... purpose of the Committee is to advise the Secretary of Veterans Affairs on the maintenance and periodic...

  1. 77 FR 34128 - Advisory Committee on Disability Compensation, Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... Affairs (VA) gives notice under Public Law 92-463 (Federal Advisory Committee Act) that the Advisory... the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities. The Committee is...

  2. Advanced Ground Systems Maintenance Cryogenics Test Lab Control System Upgrade Project

    NASA Technical Reports Server (NTRS)

    Harp, Janice Leshay

    2014-01-01

    This project will outfit the Simulated Propellant Loading System (SPLS) at KSC's Cryogenics Test Laboratory with a new programmable logic control system. The control system upgrade enables the Advanced Ground Systems Maintenace Element Integration Team and other users of the SPLS to conduct testing in a controls environment similar to that used at the launch pad.

  3. Differential introgression and the maintenance of species boundaries in an advanced generation avian hybrid zone.

    PubMed

    Walsh, Jennifer; Shriver, W Gregory; Olsen, Brian J; Kovach, Adrienne I

    2016-03-22

    Evolutionary processes, including selection and differential fitness, shape the introgression of genetic material across a hybrid zone, resulting in the exchange of some genes but not others. Differential introgression of molecular or phenotypic markers can thus provide insight into factors contributing to reproductive isolation. We characterized patterns of genetic variation across a hybrid zone between two tidal marsh birds, Saltmarsh (Ammodramus caudacutus) and Nelson's (A. nelsoni) sparrows (n = 286), and compared patterns of introgression among multiple genetic markers and phenotypic traits. Geographic and genomic cline analyses revealed variable patterns of introgression among marker types. Most markers exhibited gradual clines and indicated that introgression exceeds the spatial extent of the previously documented hybrid zone. We found steeper clines, indicating strong selection for loci associated with traits related to tidal marsh adaptations, including for a marker linked to a gene region associated with metabolic functions, including an osmotic regulatory pathway, as well as for a marker related to melanin-based pigmentation, supporting an adaptive role of darker plumage (salt marsh melanism) in tidal marshes. Narrow clines at mitochondrial and sex-linked markers also offer support for Haldane's rule. We detected patterns of asymmetrical introgression toward A. caudacutus, which may be driven by differences in mating strategy or differences in population density between the two species. Our findings offer insight into the dynamics of a hybrid zone traversing a unique environmental gradient and provide evidence for a role of ecological divergence in the maintenance of pure species boundaries despite ongoing gene flow.

  4. Maintenance treatment of advanced non-small-cell lung cancer: results of an international expert panel meeting of the Italian association of thoracic oncology.

    PubMed

    Gridelli, Cesare; de Marinis, Filippo; Di Maio, Massimo; Ardizzoni, Andrea; Belani, Chandra P; Cappuzzo, Federico; Ciardiello, Fortunato; Fidias, Panagiotis; Paz-Ares, Luis; Perrone, Francesco; Pirker, Robert; De Petris, Luigi; Stahel, Rolf

    2012-06-01

    Several randomized trials have recently investigated the role of maintenance treatment for patients with advanced non-small-cell lung cancer (NSCLC) with responding or stable disease after completion of first-line chemotherapy. Maintenance strategy has relevant implications in terms of potential toxicity, logistics and costs, and all of these aspects should be taken into account, together with the magnitude of benefit for the patient. In order to assess the strengths and limitations of available evidence, to help clinical practice, and to suggest priorities for future clinical research, the Italian Association of Thoracic Oncology (AIOT) organized an International Experts Panel Meeting on maintenance treatment of advanced NSCLC, which took place in Sperlonga (Italy) in May 2011. Based on the available evidence, panelists agreed that maintenance therapy represents a treatment option in advanced NSCLC. Maintenance should be discussed with patients not progressed after 4-6 cycles of first-line chemotherapy, who are fit (performance status 0-1) and without persistent chemotherapy-induced toxicity. Patients need to be well informed about potential advantages and disadvantages of accepting additional therapy without a "treatment-free period". Two different strategies, switch or continuation maintenance, are supported by available evidence. At the moment, there is no direct comparison between switch maintenance and continuation maintenance. For future trials, the panel recommends the use of overall survival as the primary endpoint, with pre-defined second-line treatment. Translational research is essential to identify predictive factors, and should be performed, whenever feasible, in order to achieve treatment optimization with proper patient selection. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  5. Intelligent Systems and Advanced User Interfaces for Design, Operation, and Maintenance of Command Management Systems

    NASA Technical Reports Server (NTRS)

    Mitchell, Christine M.

    1998-01-01

    Historically Command Management Systems (CMS) have been large, expensive, spacecraft-specific software systems that were costly to build, operate, and maintain. Current and emerging hardware, software, and user interface technologies may offer an opportunity to facilitate the initial formulation and design of a spacecraft-specific CMS as well as a to develop a more generic or a set of core components for CMS systems. Current MOC (mission operations center) hardware and software include Unix workstations, the C/C++ and Java programming languages, and X and Java window interfaces representations. This configuration provides the power and flexibility to support sophisticated systems and intelligent user interfaces that exploit state-of-the-art technologies in human-machine systems engineering, decision making, artificial intelligence, and software engineering. One of the goals of this research is to explore the extent to which technologies developed in the research laboratory can be productively applied in a complex system such as spacecraft command management. Initial examination of some of the issues in CMS design and operation suggests that application of technologies such as intelligent planning, case-based reasoning, design and analysis tools from a human-machine systems engineering point of view (e.g., operator and designer models) and human-computer interaction tools, (e.g., graphics, visualization, and animation), may provide significant savings in the design, operation, and maintenance of a spacecraft-specific CMS as well as continuity for CMS design and development across spacecraft with varying needs. The savings in this case is in software reuse at all stages of the software engineering process.

  6. Intelligent systems and advanced user interfaces for design, operation, and maintenance of command management systems

    NASA Technical Reports Server (NTRS)

    Potter, William J.; Mitchell, Christine M.

    1993-01-01

    Historically, command management systems (CMS) have been large and expensive spacecraft-specific software systems that were costly to build, operate, and maintain. Current and emerging hardware, software, and user interface technologies may offer an opportunity to facilitate the initial formulation and design of a spacecraft-specific CMS as well as to develop a more generic CMS system. New technologies, in addition to a core CMS common to a range of spacecraft, may facilitate the training and enhance the efficiency of CMS operations. Current mission operations center (MOC) hardware and software include Unix workstations, the C/C++ programming languages, and an X window interface. This configuration provides the power and flexibility to support sophisticated and intelligent user interfaces that exploit state-of-the-art technologies in human-machine interaction, artificial intelligence, and software engineering. One of the goals of this research is to explore the extent to which technologies developed in the research laboratory can be productively applied in a complex system such as spacecraft command management. Initial examination of some of these issues in CMS design and operation suggests that application of technologies such as intelligent planning, case-based reasoning, human-machine systems design and analysis tools (e.g., operator and designer models), and human-computer interaction tools (e.g., graphics, visualization, and animation) may provide significant savings in the design, operation, and maintenance of the CMS for a specific spacecraft as well as continuity for CMS design and development across spacecraft. The first six months of this research saw a broad investigation by Georgia Tech researchers into the function, design, and operation of current and planned command management systems at Goddard Space Flight Center. As the first step, the researchers attempted to understand the current and anticipated horizons of command management systems at Goddard

  7. Effects of Depth on Dredging Frequency. Report 3. Evaluation of Advance Maintenance Projects.

    DTIC Science & Technology

    1985-04-01

    to 1)rovide a p rede te rmi ned amiis’t () If L-;) Lhint c a pa( I it v he Ilow les jgz dtepth.i ItL is exclIus ive of the alIlIowah Ie ulre-lg Iig t...p roject s wh ichi infl tdod advance ma LI t ellal ce w Ii 11 h u h s wh I did ( to . Dlat I. used wv e of) Lb a I ned f rom p red redcge- aInd postdr...was conducted during the period 1978 to 1982 under the di- rection of Messrs. H. B. Simmons and F. A. Herrmann , Jr., former and present Chiefs of the

  8. Advanced model-based control studies for the induction and maintenance of intravenous anaesthesia.

    PubMed

    Naşcu, Ioana; Krieger, Alexandra; Ionescu, Clara Mihaela; Pistikopoulos, Efstratios N

    2015-03-01

    This paper describes strategies toward model-based automation of intravenous anaesthesia employing advanced control techniques. In particular, based on a detailed compartmental mathematical model featuring pharmacokinetic and pharmacodynamics information, two alternative model predictive control strategies are presented: a model predictive control strategy, based on online optimization, the extended predictive self-adaptive control and a multiparametric control strategy based on offline optimization, the multiparametric model predictive control. The multiparametric features to account for the effect of nonlinearity and the impact of estimation are also described. The control strategies are tested on a set of 12 virtually generated patient models for the regulation of the depth of anaesthesia by means of the bispectral index (BIS) using Propofol as the administrated anaesthetic. The simulations show fast response, suitability of dose, and robustness to induce and maintain the desired BIS setpoint.

  9. The prognostic significance of optimal debulking in the setting of a complete clinical response for advanced ovarian carcinoma patients receiving maintenance chemotherapy.

    PubMed

    Abaid, Lisa N; Goldstein, Bram H; Lopez, Katrina L; Micha, John P; Brown, John V; Rettenmaier, Mark A; Markman, Maurie

    2011-05-01

    We investigated if optimal surgical debulking increases tumor responsiveness to maintenance chemotherapy and improves survival in advanced ovarian cancer patients who previously attained a clinical complete response (CCR) to primary chemotherapy. We retrospectively reviewed 75 advanced ovarian cancer patients, of whom 43 and 32 underwent optimal versus suboptimal cytoreduction, respectively. All patients exhibited a CCR following 6 cycles of paclitaxel and carboplatin and subsequently received maintenance chemotherapy (paclitaxel 135 mg/m(2); q21 days). The median progression free survival (PFS) for the optimally debulked patients was 35 months, compared to 20 months for the suboptimal population (P = 0.003). Moreover, a Cox model analysis revealed that an increased number of maintenance chemotherapy cycles and optimal surgical reduction significantly correlated with favorable patient PFS (P < 0.001). In regard to overall survival (OS), the patients who had optimal cytoreductive surgery exhibited improved OS results compared to the sub-optimal surgery group (42 vs. 27 months; P < 0.001). However, a Cox model analysis indicated that a greater number of maintenance chemotherapy cycles was a surrogate marker for improved OS (P < 0.001), but surgery type was not (P > 0.05). Duration of overall patient follow-up exceeds 41 months. In advanced ovarian cancer patients who achieve a CCR following induction chemotherapy, optimal cytoreduction may confer a greater clinical benefit from a maintenance approach compared to suboptimal cytoreduction.

  10. Improving Space Object Catalog Maintenance Through Advances in Solar Radiation Pressure Modeling

    NASA Astrophysics Data System (ADS)

    McMahon, J.; Scheeres, D.

    the improved solar radiation pressure models can therefore help to alleviate track correlation, object identification, and sensor tasking issues that plague current catalog maintenance due to the standard inaccurate dynamic model.

  11. Approval summary: pemetrexed maintenance therapy of advanced/metastatic nonsquamous, non-small cell lung cancer (NSCLC).

    PubMed

    Cohen, Martin H; Cortazar, Patricia; Justice, Robert; Pazdur, Richard

    2010-01-01

    On July 2, 2009, the U.S. Food and Drug Administration approved pemetrexed injection (Alimta® Injection; Eli Lilly and Company, Indianapolis, IN) for maintenance treatment of patients with locally advanced or metastatic nonsquamous non-small cell lung cancer whose disease has not progressed after four cycles of platinum-based doublet induction chemotherapy. A double-blind study of pemetrexed plus best supportive care versus placebo plus best supportive care was conducted. Pemetrexed, 500 mg/m(2) i.v., was administered every 21 days until disease progression. Folic acid, vitamin B(12), and a corticosteroid were given to all study patients. There were 663 randomized patients (pemetrexed, 441; placebo, 222). Treatments were well balanced with respect to baseline disease characteristics and stratification factors. The median overall survival (OS) time for intent-to-treat (ITT) patients was 13.4 months for patients receiving pemetrexed and 10.6 months for those receiving placebo (hazard ratio [HR] 0.79; 95% confidence interval [CI], 0.65-0.95; p = .012). Median OS times were 15.5 months versus 10.3 months for patients with nonsquamous histologies receiving pemetrexed and placebo, respectively (HR, 0.70; 95% CI, 0.56-0.88). The median OS time in patients with squamous histology receiving pemetrexed was 9.9 months, versus 10.8 months for those receiving placebo (HR, 1.07; 95% CI, 0.77-1.50). A significantly longer progression-free survival interval for both the ITT and nonsquamous patient populations receiving pemetrexed maintenance therapy was also observed. The most common (>5%) adverse reactions in patients receiving pemetrexed were hematologic toxicity, an increase in hepatic enzymes, fatigue, gastrointestinal toxicity, sensory neuropathy, and skin rash.

  12. Approval Summary: Pemetrexed Maintenance Therapy of Advanced/Metastatic Nonsquamous, Non-Small Cell Lung Cancer (NSCLC)

    PubMed Central

    Cortazar, Patricia; Justice, Robert; Pazdur, Richard

    2010-01-01

    On July 2, 2009, the U.S. Food and Drug Administration approved pemetrexed injection (Alimta® Injection; Eli Lilly and Company, Indianapolis, IN) for maintenance treatment of patients with locally advanced or metastatic nonsquamous non-small cell lung cancer whose disease has not progressed after four cycles of platinum-based doublet induction chemotherapy. A double-blind study of pemetrexed plus best supportive care versus placebo plus best supportive care was conducted. Pemetrexed, 500 mg/m2 i.v., was administered every 21 days until disease progression. Folic acid, vitamin B12, and a corticosteroid were given to all study patients. There were 663 randomized patients (pemetrexed, 441; placebo, 222). Treatments were well balanced with respect to baseline disease characteristics and stratification factors. The median overall survival (OS) time for intent-to-treat (ITT) patients was 13.4 months for patients receiving pemetrexed and 10.6 months for those receiving placebo (hazard ratio [HR] 0.79; 95% confidence interval [CI], 0.65–0.95; p = .012). Median OS times were 15.5 months versus 10.3 months for patients with nonsquamous histologies receiving pemetrexed and placebo, respectively (HR, 0.70; 95% CI, 0.56–0.88). The median OS time in patients with squamous histology receiving pemetrexed was 9.9 months, versus 10.8 months for those receiving placebo (HR, 1.07; 95% CI, 0.77–1.50). A significantly longer progression-free survival interval for both the ITT and nonsquamous patient populations receiving pemetrexed maintenance therapy was also observed. The most common (>5%) adverse reactions in patients receiving pemetrexed were hematologic toxicity, an increase in hepatic enzymes, fatigue, gastrointestinal toxicity, sensory neuropathy, and skin rash. PMID:21148615

  13. 49 CFR 95.9 - Meetings; other than industry advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Meetings; other than industry advisory committees... Meetings; other than industry advisory committees. (a) Meetings of an advisory committee, other than an industry advisory committee, may be held only at the call, or with the advance approval, of a full-time...

  14. Safety Analyses of Pemetrexed-cisplatin and Pemetrexed Maintenance Therapies in Patients With Advanced Non-squamous NSCLC: Retrospective Analyses From 2 Phase III Studies.

    PubMed

    Langer, Corey J; Paz-Ares, Luis G; Wozniak, Antoinette J; Gridelli, Cesare; de Marinis, Filippo; Pujol, Jean-Louis; San Antonio, Belen; Chen, Jian; Liu, Jingyi; Oton, Ana B; Visseren-Grul, Carla; Scagliotti, Giorgio V

    2017-09-01

    In a phase III study, maintenance pemetrexed showed superior survival over placebo (PARAMOUNT) for patients with advanced non-squamous non-small cell lung cancer (NSCLC) who completed 4 cycles of pemetrexed plus cisplatin (PC) induction therapy, with low incidence of treatment-emergent adverse events (TEAEs) generally associated with pemetrexed. Prior analyses did not account for toxicities carried over from induction; thus, the current analysis was developed to understand toxicities that may be attributed to pemetrexed maintenance versus PC induction, and how treatment duration affects toxicity. Selected clinically relevant TEAEs were explored in 2 analyses: assessing induction versus maintenance treatment in PARAMOUNT, and comparing PC from PARAMOUNT with toxicity data from a previous phase III study that established the role of PC in front-line therapy of non-squamous NSCLC (JMDB trial). In PARAMOUNT, the incidence of most drug-related TEAEs was higher during induction than maintenance, for both the pemetrexed and placebo randomized populations. The majority of TEAEs during maintenance, except renal events, were carried over from induction with no change in severity from the end of induction; the incidence of TEAEs associated with pemetrexed maintenance was low. The cross-trial analysis showed that 6 cycles of PC in JMDB compared with 4 cycles in PARAMOUNT increased grade 1/2 fatigue (34.1% vs. 25.0%), anemia (24.0% vs. 13.5%), and renal events (11.8% vs. 3.6%). Safety data presented here support the favorable risk benefit of 4 cycles of PC followed by maintenance pemetrexed in patients with advanced non-squamous NSCLC. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. 76 FR 6196 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-03

    ... No: 2011-2337] DEPARTMENT OF VETERANS AFFAIRS Advisory Committee on Disability Compensation; Notice... Advisory Committee Act) that the Advisory Committee on Disability Compensation will meet on Monday... Affairs on the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities....

  16. Comparison of the efficacy and tolerability of gefitinib with pemetrexed maintenance after first-line platinum-based doublet chemotherapy in advanced lung adenocarcinoma: single-center experience.

    PubMed

    Lin, Liping; Zhao, Juanjuan; Hu, Jiazhu; Huang, Fuxi; Han, Jianjun; He, Yan; Cao, Xiaolong

    2016-01-01

    Both gefitinib and pemetrexed maintenance were effective therapies for advanced lung adenocarcinoma, but which is better is unclear. For patients with advanced lung adenocarcinoma, we have no idea whether we should choose gefitinib or pemetrexed maintenance in clinical practice. Here, we assessed the efficacy and tolerability of gefitinib versus pemetrexed maintenance in these patients. A total of 101 patients were identified and divided into gefitinib (n=53) or pemetrexed (n=48) maintenance. Epidermal growth factor receptor (EGFR) status of tumors was analyzed in 67 patients. Disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) were compared between the two groups. The results showed that DCR (79.2% vs 75%, P=0.642) was similar between gefitinib and pemetrexed groups. The PFS of gefitinib was significantly longer than that of pemetrexed (8 months vs 5.4 months, hazard ratio [HR]: 0.520, 95% confidence interval [CI]: 0.341-0.791, P=0.002); however, the OS was similar (19.9 months vs 18.8 months, HR: 1.006, 95% CI: 0.664-1.525, P=0.977). In EGFR mutation-positive patients, PFS was significantly longer in gefitinib (12 months vs 5.4 months; HR: 0.158, 95% CI: 0.074-0.333, P<0.001), whereas in EGFR wild-type subgroup gefitinib had a significantly shorter PFS than that by pemetrexed (2.5 months vs 5 months; HR: 2.822, 95% CI: 1.137-7.005, P=0.025). Cox multivariate regression analysis of PFS for overall population showed that smoking status (P=0.001) and maintenance regimens (P=0.013) were independent prognostic factors for PFS. Both gefitinib and pemetrexed were well tolerated. Gefitinib compared with pemetrexed as maintenance therapy had a significantly longer PFS and a similar OS with good tolerability in patients with advanced lung adenocarcinoma. Moreover, for EGFR mutation-positive patients, gefitinib maintenance had a significantly longer PFS; however, pemetrexed maintenance was considered more effective for EGFR wild

  17. Maintenance erlotinib versus erlotinib at disease progression in patients with advanced non-small-cell lung cancer who have not progressed following platinum-based chemotherapy (IUNO study).

    PubMed

    Cicènas, Saulius; Geater, Sarayut Lucien; Petrov, Petar; Hotko, Yevgeniy; Hooper, Gregory; Xia, Fan; Mudie, Nadejda; Wu, Yi-Long

    2016-12-01

    The phase III IUNO trial assessed the benefit of maintenance erlotinib versus erlotinib at progression in advanced/metastatic non-small-cell lung cancer (NSCLC) that had not progressed following four cycles of platinum-based chemotherapy. Patients had stage IIIB/IV NSCLC, no known epidermal growth factor receptor (EGFR)-activating mutation, and objective response or disease stabilization after platinum-based induction chemotherapy. Central EGFR-mutation testing was undertaken on tumors from patients with unknown or wild-type EGFR status following local testing. Patients were randomized to receive blinded maintenance erlotinib 150mg/day ('early erlotinib') or placebo. Those who progressed on placebo received open-label erlotinib ('late erlotinib'); patients who progressed on erlotinib received approved second-line chemotherapy or best supportive care. Primary endpoint: overall survival (OS). 643 patients were randomized to receive maintenance erlotinib (n=322) or placebo (n=321). As of March 23, 2015, 242 (75.2%) OS events had occurred with 'early erlotinib' versus 235 (73.2%) with 'late erlotinib'. Median OS was 9.7 and 9.5 months with 'early erlotinib' and 'late erlotinib', respectively (HR, 1.02, 95% CI: 0.85-1.22; log-rank p=0.82). No progression-free survival, objective response rate, or disease control rate benefit was observed with maintenance erlotinib. 410 patients entered the second-line phase of the study: 160 patients (50%) from the maintenance erlotinib arm and 250 patients (78%) from the maintenance placebo arm. The pattern of adverse events (AEs) was consistent with previous trials; 11 patients who received blinded erlotinib and 3 who received placebo died during the blinded maintenance phase due to nontreatment-related AEs. OS with maintenance erlotinib was not superior to second-line treatment in patients whose tumor did not harbor an EGFR-activating mutation. Safety results were consistent with the established safety profile of erlotinib. Thus

  18. Continuation maintenance therapy with S-1 in chemotherapy-naïve patients with advanced squamous cell lung cancer.

    PubMed

    Suzuki, Seiichiro; Karayama, Masato; Inui, Naoki; Fujisawa, Tomoyuki; Enomoto, Noriyuki; Nakamura, Yutaro; Kuroishi, Shigeki; Matsuda, Hiroyuki; Yokomura, Koshi; Koshimizu, Naoki; Toyoshima, Mikio; Imokawa, Shiro; Asada, Kazuhiro; Masuda, Masafumi; Yamada, Takashi; Watanabe, Hiroshi; Suda, Takafumi

    2016-08-01

    Objectives Maintenance therapy is a standard therapeutic strategy in non-squamous non-small-cell lung cancer. However, there is no consensus regarding the benefit of maintenance therapy for patients with squamous cell lung cancer. We assessed maintenance therapy with S-1, an oral fluoropyrimidine agent, following induction therapy with carboplatin and S-1 in patients with squamous cell lung cancer. Methods In this phase II trial, chemotherapy-naïve patients with squamous cell lung cancer were enrolled to induction therapy with four cycles of carboplatin (at an area under the curve of 5 on day 1) and S-1 (80 mg/m(2)/day on days 1-14) in a 28-day cycle. Patients who achieved disease control after induction therapy received maintenance therapy with S-1 in a 21-day cycle until disease progression or unacceptable toxicity. The primary endpoint was progression-free survival after administration of maintenance therapy. Results Fifty-one patients were enrolled in the study. The median progression-free survival from the start of maintenance therapy was 3.0 months (95 % confidence interval, 2.5-3.5). The most common toxicities associated with maintenance therapy were anemia, thrombocytopenia, and fatigue, but they were not severe. Conclusion S-1 maintenance therapy might be a feasible treatment option in patients with squamous cell lung cancer.

  19. Evaluation of prototype Advanced Life Support (ALS) pack for use by the Health Maintenance Facility (HMF) on Space Station Freedom (SSF)

    NASA Technical Reports Server (NTRS)

    Krupa, Debra T.; Gosbee, John; Murphy, Linda; Kizzee, Victor D.

    1991-01-01

    The purpose is to evaluate the prototype Advanced Life Support (ALS) Pack which was developed for the Health Maintenance Facility (HMF). This pack will enable the Crew Medical Officer (CMO) to have ready access to advanced life support supplies and equipment for time critical responses to any situation within the Space Station Freedom. The objectives are: (1) to evaluate the design of the pack; and (2) to collect comments for revision to the design of the pack. The in-flight test procedures and other aspects of the KC-135 parabolic test flight to simulate weightlessness are presented.

  20. Cryogenics maintenance strategy

    NASA Astrophysics Data System (ADS)

    Cruzat, Fabiola

    2012-09-01

    ALMA is an interferometer composed of 66 independent systems, with specific maintenance requirements for each subsystem. To optimize the observation time and reduce downtime maintenance, requirements are very demanding. One subsystem with high maintenance efforts is cryogenics and vacuum. To organize the maintenance, the Cryogenic and Vacuum department is using and implementing different tools. These are monitoring and problem reporting systems and CMMS. This leads to different maintenance approaches: Preventive Maintenance, Corrective Maintenance and Condition Based Maintenance. In order to coordinate activities with other departments the preventive maintenance schedule is kept as flexible as systems allow. To cope with unavoidable failures, the team has to be prepared to work under any condition with the spares on time. Computerized maintenance management system (CMMS) will help to manage inventory control for reliable spare part handling, the correct record of work orders and traceability of maintenance activities. For an optimized approach the department is currently evaluating where preventive or condition based maintenance applies to comply with the individual system demand. Considering the change from maintenance contracts to in-house maintenance will help to minimize costs and increase availability of parts. Due to increased number of system and tasks the cryo team needs to grow. Training of all staff members is mandatory, in depth knowledge must be built up by doing complex maintenance activities in the Cryo group, use of advanced computerized metrology systems.

  1. Estimated Creatinine Clearance Rate Is Associated With the Treatment Effectiveness and Toxicity of Pemetrexed As Continuation Maintenance Therapy for Advanced Nonsquamous Non-Small-Cell Lung Cancer.

    PubMed

    Chen, Chung-Yu; Lin, Jou-Wei; Huang, Jenq-Wen; Chen, Kuan-Yu; Shih, Jin-Yuan; Yu, Chong-Jen; Yang, Pan-Chyr

    2015-11-01

    The purpose of this study was to explore the predictive factors of the effectiveness and treatment toxicity for pemetrexed as continuation maintenance therapy in patients with advanced nonsquamous non-small-cell lung cancer. Patients with an estimated creatinine clearance rate (Ccr) < 60 mL/min had a significantly longer survival. However, a decrease in estimated Ccr was associated with a increased risk of Grade 3/4 neutropenia and anemia. The purpose of this study was to explore the predictive factors of the effectiveness and treatment toxicity for pemetrexed as continuation maintenance therapy in patients with advanced nonsquamous non-small-cell lung cancer (NSCLC). Patients with advanced nonsquamous NSCLC treated with pemetrexed as continuation maintenance therapy were enrolled. The medical records were reviewed and analyzed, including data on basic characteristics, estimated creatinine clearance rate (Ccr), treatment responses, progression-free survival (PFS), overall survival (OS), and treatment-related toxicities. A total of 124 patients were included and all had adenocarcinoma. Patients with an estimated Ccr < 60 mL/min had a significantly longer PFS and OS (P = .045, and P = .006, respectively). Each 10 mL/min increase in estimated Ccr was associated with an increase of 9.8% in the risk of disease progression, and an increase of 9.2% in the risk of death. In contrast, an increase of 10 mL/min in estimated Ccr was associated with a decreased risk of Grade 3/4 neutropenia by 50.9% and anemia by 42.2%. Estimated Ccr is helpful in predicting the effectiveness and treatment toxicities of pemetrexed maintenance therapy. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Cost-effectiveness of maintenance pemetrexed in patients with advanced nonsquamous-cell lung cancer from the perspective of the Swiss health care system.

    PubMed

    Matter-Walstra, Klazien; Joerger, Markus; Kühnel, Ursula; Szucs, Thomas; Pestalozzi, Bernhard; Schwenkglenks, Matthias

    2012-01-01

    A recent randomized study showed switch maintenance with pemetrexed after nonpemetrexed-containing first-line chemotherapy in patients with advanced nonsmall-cell lung cancer to prolong overall survival by 2.8 months. We examined the cost-effectiveness of pemetrexed in this indication, from the perspective of the Swiss health care system, and assessed the influence of the costs of best supportive care (BSC) on overall cost-effectiveness. A Markov model was constructed based on the pemetrexed maintenance study, and the incremental cost-effectiveness ratio (ICER) of adding pemetrexed until disease progression was calculated as cost per quality-adjusted life-year gained. Uncertainties concerning the costs of BSC on the ICER were addressed. The base case ICER for maintenance therapy with pemetrexed plus BSC compared to BSC alone was €106,202 per quality-adjusted life-year gained. Varying the costs for BSC had a marked effect. Assuming a reduction of the costs for BSC by 25% in the pemetrexed arm resulted in an ICER of €47,531 per quality-adjusted life-year, which is below predefined criteria for cost effectiveness in Switzerland. Switch maintenance with pemetrexed in patients with advanced nonsquamous-cell lung cancer after standard first-line chemotherapy is not cost-effective. Uncertainties on the resource use and costs for BSC have a large influence on the cost-effectiveness calculation and should be reported in more detail. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  3. Cisplatin/Pemetrexed Followed by Maintenance Pemetrexed Versus Carboplatin/Paclitaxel/Bevacizumab Followed by Maintenance Bevacizumab in Advanced Nonsquamous Lung Cancer: The GOIM (Gruppo Oncologico Italia Meridionale) ERACLE Phase III Randomized Trial.

    PubMed

    Galetta, Domenico; Cinieri, Saverio; Pisconti, Salvatore; Gebbia, Vittorio; Morabito, Alessandro; Borsellino, Nicola; Maiello, Evaristo; Febbraro, Antonio; Catino, Annamaria; Rizzo, Pietro; Montrone, Michele; Misino, Andrea; Logroscino, Antonio; Rizzi, Daniele; Di Maio, Massimo; Colucci, Giuseppe

    2015-07-01

    Cisplatin with pemetrexed (CP) and carboplatin with paclitaxel and bevacizumab (CbTB) are standard first-line treatments for patients with advanced nonsquamous (NS) non-small-cell lung cancer (NSCLC). Quality of life (QoL) is a key objective in the management of advanced NSCLC. Thus, effect on QoL could be an additional factor in the choice of treatment. Patients with untreated stage IIIB/IV NS-NSCLC and Eastern Cooperative Oncology Group performance status of 0 or 1 were randomized to receive first-line chemotherapy with cisplatin 75 mg/m(2) and pemetrexed 500 mg/m(2), every 3 weeks, for 6 cycles followed by maintenance pemetrexed; or carboplatin area under the curve 6, paclitaxel 200 mg/m(2), and bevacizumab 15 mg/kg, every 3 weeks, for 6 cycles followed by maintenance bevacizumab. The primary end point was the difference in QoL between the 2 treatment arms after 12 weeks of maintenance, measured using the EuroQoL 5 Dimensions-Index (EQ5D-I) and EQ5D-visual analogue scale (EQ5D-VAS). One hundred eighteen patients were randomized to CP (n = 60) or CbTB (n = 58). Baseline characteristics were well balanced. The proportion of patients evaluable for the primary end point was lower than planned. After 12 weeks of maintenance, the difference between mean changes in EQ5D-I was 0.137, favoring CP (95% confidence interval [CI], -0.02 to 0.29, Wilcoxon P = .078), although not statistically significant; and the difference between mean changes in EQ5D-VAS was 0.97 (95% CI, -9.37 to 11.31, Wilcoxon P = .41). Although the study was underpowered because of a small number of patients evaluable for the primary end point, QoL did not differ between treatment arms. Other factors such as comorbidities and schedule should be used when deciding on first-line treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

  4. Switch maintenance chemotherapy using S-1 with or without bevacizumab in patients with advanced non-small cell lung cancer: a phase II study.

    PubMed

    Niho, Seiji; Ohe, Yuichiro; Ohmatsu, Hironobu; Umemura, Shigeki; Matsumoto, Shingo; Yoh, Kiyotaka; Goto, Koichi

    2017-06-01

    We conducted this single-institute; prospective, non-randomized parallel two-arm phase II study to evaluate the efficacy and safety of switch maintenance chemotherapy with S-1 after induction therapy with a platinum-based regimen in patients with advanced non-small cell lung cancer (NSCLC). Patients not showing disease progression after induction platinum-based chemotherapy received S-1 at the dose of 40mg/m(2) twice daily for 14 consecutive days, every three weeks, with or without bevacizumab (Bev) at the dose of 15mg/kg. In cases where the induction chemotherapy regimen contained Bev, Bev was used as continuation maintenance chemotherapy where appropriate. The efficacy/toxicity of switch maintenance chemotherapy with S-1 and S-1+Bev was evaluated separately. The primary end point of this study was the treatment success rate at three months after the start of S-1 treatment. Between July 2010 and January 2014, 79 patients were enrolled, of which 78 were found to be eligible for inclusion in this study. The treatment success rate at three months was 28.2% (90% confidence interval (CI), 7.1-17.1%) in the S-1 group and 64.1% (90% CI, 50.0-76.8%) in the S-1+Bev group. The primary endpoint was met in the S-1+Bev group. The median PFS and OS were 2.6 months and 11.0 months in the S-1 group, and 4.6 months and 19.9 months in the S-1+Bev group, respectively. The most common grade three toxicity was neutropenia (10% incidence in the S-1+Bev group). There were no cases of febrile neutropenia. Switch maintenance chemotherapy with S-1 in combination with continuation maintenance chemotherapy with bevacizumab yielded modest efficacy with mild and acceptable toxicities. Copyright © 2017. Published by Elsevier B.V.

  5. Renal insufficiency is the leading cause of double maintenance (bevacizumab and pemetrexed) discontinuation for toxicity to advanced non-small cell lung cancer in real world setting.

    PubMed

    Sassier, Marion; Dugué, Audrey Emmanuelle; Clarisse, Bénédicte; Lesueur, Paul; Avrillon, Virginie; Bizieux-Thaminy, Acya; Auliac, Jean-Bernard; Kaluzinski, Laure; Tillon, Julie; Robinet, Gilles; Le Caer, Hervé; Monnet, Isabelle; Madroszyk, Anne; Boza, Gabriella; Falchero, Lionel; Fournel, Pierre; Egenod, Thomas; Toffart, Anne-Claire; Leiber, Nathalie; Do, Pascal; Gervais, Radj

    2015-08-01

    In advanced non-small cell lung cancer (NSCLC), maintenance therapy has emerged as a novel therapeutic reference for patients with non-progressive disease after platinum-based induction chemotherapy. However, the use of double maintenance (DM) with pemetrexed and bevacizumab is still being evaluated in terms of its clinical benefits and safety profile. The objective of this retrospective study was to describe the reasons for DM discontinuation in a real-world setting. Patients with advanced non-squamous NSCLC were eligible if they had received at least 4 cycles of induction chemotherapy, followed by at least 1 cycle of DM. They were identified by using the oncology pharmacy database of 17 French centers. Eighty-one patients who began a DM after induction chemotherapy were identified from September 2009 to April 2013. Among the 78 patients who had stopped DM at the time of the analysis, the main reasons for discontinuation were disease progression (42%), adverse events (33%), and personal preference (8%). The most frequent toxicity responsible for DM discontinuation was renal insufficiency (54%). For patients with advanced NSCLC eligible for DM therapy, a particular attention should be paid to potential renal failure. Kidney function should be monitored carefully before and during DM to detect and manage early this adverse event. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  6. Final Report of the Advanced Coal Technology Work Group

    EPA Pesticide Factsheets

    The Advanced Coal Technology workgroup reported to the Clean Air Act Advisory Committee. This page includes the final report of the Advanced Coal Technology Work Group to the Clean Air Act Advisory Committee.

  7. Home administration of maintenance pemetrexed for patients with advanced non-squamous non-small cell lung cancer: rationale, practicalities and phase II feasibility study design

    PubMed Central

    2013-01-01

    Background Home-based care in oncology is mainly reserved for patients at the end of life. Regulations regarding home delivery of cytotoxics differ across Europe, with a notable lack of practice guidelines in most countries. This has led to a lack of data addressing the feasibility of home-based administration of cytotoxic chemotherapy. In advanced non-squamous non-small cell lung cancer, pemetrexed is approved as maintenance therapy after first-line chemotherapy. In this setting, patients have the potential to be treated long-term with maintenance therapy, which, in the absence of unacceptable toxicity, is continued until disease progression. The favourable safety profile of pemetrexed and the ease of its administration by 10-minute intravenous infusion every 3 weeks make this drug a suitable candidate for administration in a home setting. Methods Literature and regulations relevant to the home-based delivery of cytotoxic therapy were reviewed, and a phase II feasibility study of home administration of pemetrexed maintenance therapy was designed. At least 50 patients with advanced non-squamous non-small cell lung cancer, Eastern Cooperative Oncology Group performance status 0–1 and no progressive disease after four cycles of platinum-based first-line therapy are required to allow investigation of the feasibility of home-based administration of pemetrexed maintenance therapy (500 mg/m2 every 3 weeks until progressive disease or unacceptable toxicity). Feasibility is being assessed as adherence to the home-based administration process (primary endpoint), patient safety, impact on patients’ quality of life, patient and physician satisfaction with home care, and healthcare resource use and costs. Enrolment of patients from the UK and Sweden, where home-based care is relatively well developed, commenced in December 2011. Discussion This feasibility study addresses an important aspect of maintenance therapy, that is, patient comfort during protracted home

  8. Shortened intensified multi-agent chemotherapy and non-cross resistant maintenance therapy for advanced lymphoblastic lymphoma in children and adolescents: report from the Children's Oncology Group.

    PubMed

    Abromowitch, Minnie; Sposto, Richard; Perkins, Sherrie; Zwick, David; Siegel, Stuart; Finlay, Jonathan; Cairo, Mitchell S

    2008-10-01

    Pediatric lymphoblastic lymphoma (LL) has utilized treatment strategies similar to childhood acute lymphoblastic leukaemia (ALL) with prolonged maintenance chemotherapy. We report the results of a pilot study to estimate the feasibility, toxicity and efficacy of a 12-month aggressive multi-agent chemotherapy regimen in children and adolescents with advanced LL. Between July 1994 and June 1997, 85 eligible children and adolescents with advanced LL (Stage III/IV) were enrolled on this pilot study. Patients achieving a complete response following induction and consolidation received six cycles of maintenance chemotherapy for a total duration of 12 months. Grade III/IV toxicities included: hematological (80%), infections (20%), stomatitis and elevated transaminases, (29%). There were a total of 19 events, 13 relapses, two secondary acute myeloid leukaemia and four toxic deaths (5%). The 5-year event-free survival (EFS) and overall survival (OS) was 78 +/- 4.5% and 85 +/- 3.9%, respectively. Relapsed patients had a 5-year OS of only 33 +/- 14%. Multivariate analysis failed to demonstrate age, gender, lactate dehydrogenase level, presence of marrow and/or central nervous system disease to have independent prognostic value. These results suggest that this experimental approach is safe and results in similar outcomes as more prolonged childhood ALL regimens.

  9. XELOX and bevacizumab followed by single-agent bevacizumab as maintenance therapy as first-line treatment in elderly patients with advanced colorectal cancer: the boxe study.

    PubMed

    Rosati, Gerardo; Avallone, Antonio; Aprile, Giuseppe; Butera, Alfredo; Reggiardo, Giorgio; Bilancia, Domenico

    2013-01-01

    The addition of bevacizumab to oxaliplatin-based chemotherapy significantly improved progression-free survival (PFS) in patients with metastatic colorectal cancer (CRC). An increased risk of arterial thromboembolic events has been observed in some trials in older patients, and the potential benefit of a maintenance therapy with bevacizumab alone has not been clearly demonstrated. This phase II study was designed to evaluate the efficacy and safety of XELOX (capecitabine plus oxaliplatin) plus bevacizumab followed by bevacizumab alone in elderly patients with advanced CRC. Treatment consisted of bevacizumab 7.5 mg/kg and oxaliplatin 130 mg/m(2) on day 1, plus capecitabine 1,000 mg/m(2) twice daily on days 1-14, every 3 weeks up to a maximum of 8 cycles. Patients then received maintenance therapy consisting of bevacizumab alone (7.5 mg/kg) once every 3 weeks up to disease progression. The primary study end-points were safety and response rate. A total of 44 patients were recruited. In an intention-to-treat analysis, the overall response rate was 52% [95% confidence interval (CI) 37 to 68%], with 86% of patients achieving disease control. Median PFS and overall survival were 11.5 months (95% CI 10.0-12.9 months) and 19.3 months (95% CI 16.5-22.1 months), respectively. In all, 10 patients (23%) had grade 3/4 adverse events (AEs), the most common being diarrhea (9%), neutropenia (7%), peripheral neuropathy (7%), and stomatitis (7%). No patients died because of treatment-related AEs. The rate of bevacizumab-related AEs (hypertension, thromboembolic events, and gastrointestinal perforation) was consistent with that reported earlier in the general CRC population. The combination of XELOX and bevacizumab is effective and has a manageable tolerability profile when administered to elderly patients with advanced CRC. Maintenance therapy with single-agent bevacizumab may be considered to extend PFS in this setting of patients.

  10. 75 FR 4440 - U.S. Advisory Commission on Public Diplomacy; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-27

    .... Advisory Commission on Public Diplomacy; Notice of Meeting The U.S. Advisory Commission on Public Diplomacy... meeting will be held from 10 a.m. to 11:30 a.m. The Commissioners will discuss public diplomacy issues, including interagency collaboration in advancing U.S. government public diplomacy efforts. The Advisory...

  11. 76 FR 39080 - Environmental Management Site-Specific Advisory Board, Idaho National Laboratory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-05

    ... Environmental Management Site-Specific Advisory Board, Idaho National Laboratory AGENCY: Department of Energy... Site-Specific Advisory Board (EM SSAB), Idaho National Laboratory. The Federal Advisory Committee Act... National Laboratory (INL) 101. INL EM Budget. Calcine Path Forward. Advanced Mixed Waste Treatment Project...

  12. 75 FR 8154 - Advisory Committee on Reactor Safeguards

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    ... NRC staff regarding new advanced reactor designs such as NuScale, Iris, Babcock and Wilcox Modular... COMMISSION Advisory Committee on Reactor Safeguards In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor Safeguards (ACRS...

  13. 62 FR 26281 - National Urban and Community Forestry Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-05-13

    ... Forest Service National Urban and Community Forestry Advisory Council AGENCY: Forest Service, USDA. ACTION: Notice of meeting. ] SUMMARY: The National Urban and Community Forestry Advisory Council will... advance the knowledge of, and promote interest in, urban and community forestry needs. Pursaunt to 5 U.S.C...

  14. 76 FR 49757 - Fusion Energy Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ... Energy Sciences Advisory Committee AGENCY: Office of Science, Department of Energy. ACTION: Notice of... that the Fusion Energy Sciences Advisory Committee will be renewed for a two-year period beginning on...-range plans, priorities, and strategies for advancing plasma science, fusion science, and fusion...

  15. Discovery of pyrrolidine-based β-secretase inhibitors: lead advancement through conformational design for maintenance of ligand binding efficiency.

    PubMed

    Stachel, Shawn J; Steele, Thomas G; Petrocchi, Alessia; Haugabook, Sharie J; McGaughey, Georgia; Katharine Holloway, M; Allison, Timothy; Munshi, Sanjeev; Zuck, Paul; Colussi, Dennis; Tugasheva, Katherine; Wolfe, Abigail; Graham, Samuel L; Vacca, Joseph P

    2012-01-01

    We have developed a novel series of pyrrolidine derived BACE-1 inhibitors. The potency of the weak initial lead structure was enhanced using library-based SAR methods. The series was then further advanced by rational design while maintaining a minimal ligand binding efficiency threshold. Ultimately, the co-crystal structure was obtained revealing that these inhibitors interacted with the enzyme in a unique fashion. In all, the potency of the series was enhanced by 4 orders of magnitude from the HTS lead with concomitant increases in physical properties needed for series advancement. The progression of these developments in a systematic fashion is described.

  16. A randomized phase II study of the telomerase inhibitor imetelstat as maintenance therapy for advanced non-small-cell lung cancer.

    PubMed

    Chiappori, A A; Kolevska, T; Spigel, D R; Hager, S; Rarick, M; Gadgeel, S; Blais, N; Von Pawel, J; Hart, L; Reck, M; Bassett, E; Burington, B; Schiller, J H

    2015-02-01

    Continuation or 'switch' maintenance therapy is commonly used in patients with advancd non-small-cell lung cancer (NSCLC). Here, we evaluated the efficacy of the telomerase inhibitor, imetelstat, as switch maintenance therapy in patients with advanced NSCLC. The primary end point of this open-label, randomized phase II study was progression-free survival (PFS). Patients with non-progressive, advanced NSCLC after platinum-based doublet (first-line) chemotherapy (with or without bevacizumab), any histology, with Eastern Cooperative Oncology Group performance status 0-1 were eligible. Randomization was 2 : 1 in favor of imetelstat, administered at 9.4 mg/kg on days 1 and 8 of a 21-day cycle, or observation. Telomere length (TL) biomarker exploratory analysis was carried out in tumor tissue by quantitative PCR (qPCR) and telomerase fluorescence in situ hybridization. Of 116 patients enrolled, 114 were evaluable. Grade 3/4 neutropenia and thrombocytopenia were more frequent with imetelstat. Median PFS was 2.8 and 2.6 months for imetelstat-treated versus control [hazard ratio (HR) = 0.844; 95% CI 0.54-1.31; P = 0.446]. Median survival time favored imetelstat (14.3 versus 11.5 months), although not significantly (HR = 0.68; 95% CI 0.41-1.12; P = 0.129). Exploratory analysis demonstrated a trend toward longer median PFS (HR = 0.43; 95% CI 0.14-1.3; P = 0.124) and overall survival (OS; HR = 0.41; 95% CI 0.11-1.46; P = 0.155) in imetelstat-treated patients with short TL, but no improvement in median PFS and OS in patients with long TL (HR = 0.86; 95% CI 0.39-1.88; and HR = 0.51; 95% CI 0.2-1.28; P = 0.145). Maintenance imetelstat failed to improve PFS in advanced NSCLC patients responding to first-line therapy. There was a trend toward a improvement in median PFS and OS in patients with short TL. Short TL as a predictive biomarker will require further investigation for the clinical development of imetelstat. © The Author 2014. Published by Oxford University Press on behalf

  17. A maintenance model for k-out-of-n subsystems aboard a fleet of advanced commercial aircraft

    NASA Technical Reports Server (NTRS)

    Miller, D. R.

    1978-01-01

    Proposed highly reliable fault-tolerant reconfigurable digital control systems for a future generation of commercial aircraft consist of several k-out-of-n subsystems. Each of these flight-critical subsystems will consist of n identical components, k of which must be functioning properly in order for the aircraft to be dispatched. Failed components are recoverable; they are repaired in a shop. Spares are inventoried at a main base where they may be substituted for failed components on planes during layovers. Penalties are assessed when failure of a k-out-of-n subsystem causes a dispatch cancellation or delay. A maintenance model for a fleet of aircraft with such control systems is presented. The goals are to demonstrate economic feasibility and to optimize.

  18. Advanced technologies for maintenance of electrical systems and equipment at the Savannah River Site Defense Waste Processing Facility

    SciTech Connect

    Husler, R.O. ); Weir, T.J. )

    1991-01-01

    An enhanced maintenance program is being established to characterize and monitor cables, components, and process response at the Savannah River Site, Defense Waste Processing Facility. This facility was designed and constructed to immobilize the radioactive waste currently stored in underground storage tanks and is expected to begin operation in 1993. The plant is initiating the program to baseline and monitor instrument and control (I C) and electrical equipment, remote process equipment, embedded instrument and control cables, and in-cell jumper cables used in the facility. This program is based on the electronic characterization and diagnostic (ECAD) system which was modified to include process response analysis and to meet rigid Department of Energy equipment requirements. The system consists of computer-automated, state-of-the-art electronics. The data that are gathered are stored in a computerized database for analysis, trending, and troubleshooting. It is anticipated that the data which are gathered and trended will aid in life extension for the facility.

  19. Advancements in the maintenance of skin barrier/skin lipid composition and the involvement of metabolic enzymes.

    PubMed

    Cui, Le; Jia, Yan; Cheng, Zhi-Wei; Gao, Ying; Zhang, Gao-Lei; Li, Jing-Yi; He, Cong-Fen

    2016-12-01

    The human skin barrier has an important role in protection and defense, reflected not only in the ability to resist entry of harmful substances into the human body, but also in the ability to prevent loss of water and nutrients. Once the skin barrier is damaged, the skin may become dry, scaly, and wrinkled, and a series of skin problems may occur. In this article, we review the composition of lipids, such as ceramides, cholesterol, and free fatty acids, in the skin and examine the expression of enzymes related to lipid metabolism, such as kallikreins, elongase of elongation of very long-chain fatty acids, hydrolases, and lipid synthases. Additionally, we discuss the involvement of these proteins in skin barrier function and structure. The information presented in this review is expected to provide a theoretical basis for the development of skin care products facilitating the maintenance and repair of skin barrier function. © 2016 Wiley Periodicals, Inc.

  20. A two-stage, single-arm, phase II study of EGCG-enriched green tea drink as a maintenance therapy in women with advanced stage ovarian cancer.

    PubMed

    Trudel, Dominique; Labbé, David P; Araya-Farias, Monica; Doyen, Alain; Bazinet, Laurent; Duchesne, Thierry; Plante, Marie; Grégoire, Jean; Renaud, Marie-Claude; Bachvarov, Dimcho; Têtu, Bernard; Bairati, Isabelle

    2013-11-01

    A two-stage, single-arm, phase II study was conducted to assess the effectiveness and safety of an epigallocatechin gallate (EGCG)-enriched tea drink, the double-brewed green tea (DBGT), as a maintenance treatment in women with advanced stage serous or endometrioid ovarian cancer (clinicaltrials.gov, NCT00721890). Eligible women had FIGO stage III-IV serous or endometrioid ovarian cancer. They had to undergo complete response after debulking surgery followed by 6 to 8 cycles of platinum/taxane chemotherapy at the Centre Hospitalier Universitaire de Québec. They all had to drink the DBGT, 500 mL daily until recurrence or during a follow-up of 18 months. The primary endpoint was the absence of recurrence at 18 months. Statistical analyses were done according to the principle of intention to treat. Using a two-stage design, the first stage consisted of 16 enrolled patients. At the end of the follow-up, if 7 or fewer patients were free of recurrence, the trial stopped. Otherwise, accrual would continue to a total of 46 patients. During the first stage of the study, only 5 of the 16 women remained free of recurrence 18 months after complete response. Accordingly, the clinical trial was terminated. Women's adherence to DBGT was high (median daily intake during intervention, 98.1%, interquartile range: 89.7-100%), but 6 women discontinued the intervention before the end of their follow-up. No severe toxicity was reported. DBGT supplementation does not appear to be a promising maintenance intervention in women with advanced stage ovarian cancer after standard treatment. © 2013.

  1. Maintenance therapy with pemetrexed and bevacizumab versus pemetrexed monotherapy after induction therapy with carboplatin, pemetrexed, and bevacizumab in patients with advanced non-squamous non small cell lung cancer.

    PubMed

    Karayama, Masato; Inui, Naoki; Fujisawa, Tomoyuki; Enomoto, Noriyuki; Nakamura, Yutaro; Kuroishi, Shigeki; Yokomura, Koshi; Koshimizu, Naoki; Sato, Masaki; Toyoshima, Mikio; Shirai, Toshihiro; Masuda, Masafumi; Yamada, Takashi; Imokawa, Shiro; Suda, Takafumi

    2016-05-01

    Single agent maintenance therapy is widely accepted for advanced non-squamous non small cell lung cancer (NSCLC). However, there is no consensus on the initial and maintenance phase regimens, and the clinical benefit of adding bevacizumab to cytotoxic drugs in the maintenance phase remains unclear. Chemotherapy-naïve patients with non-squamous NSCLC were randomly assigned to maintenance therapy with pemetrexed and bevacizumab or pemetrexed alone, after achieving disease control after four cycles of induction therapy with carboplatin (area under the curve = 6), pemetrexed (500 mg/m(2)), and bevacizumab (15 mg/kg). The primary end-point was 1-year progression-free survival (PFS) rate. One hundred ten patients were enrolled in the study, with 55 patients assigned to the two groups. The mean 1-year PFS rate was 43.9% (95% confidence interval [CI]: 29.6-59.2%) in the combination maintenance group and 35.2% (95% CI: 22.1-51.0%) in the pemetrexed maintenance group, and the difference was not significant (p = 0.433). Median PFS measured from enrolment was 11.5 months (95% CI: 7.1-19.0) in the combination maintenance group and 7.3 months (95% CI: 5.7-14.1, hazard ratio: 0.73, 95% CI: 0.44-1.19, log-rank p = 0.198) in the pemetrexed maintenance group. Nasal haemorrhage, hypertension, and proteinuria were significantly more frequent in the combination maintenance group, but they were mild and tolerable. Both maintenance therapy with pemetrexed alone and pemetrexed and bevacizumab in combination were feasible in patients with non-squamous NSCLC who have achieved disease control after induction therapy with carboplatin, pemetrexed, and bevacizumab. According to the selection design, differences in the superiority between these maintenance therapies were not demonstrated. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Advanced technologies for maintenance of electrical systems and equipment at the Savannah River Site Defense Waste Processing Facility

    SciTech Connect

    Husler, R.O.; Weir, T.J.

    1991-12-31

    An enhanced maintenance program is being established to characterize and monitor cables, components, and process response at the Savannah River Site, Defense Waste Processing Facility. This facility was designed and constructed to immobilize the radioactive waste currently stored in underground storage tanks and is expected to begin operation in 1993. The plant is initiating the program to baseline and monitor instrument and control (I&C) and electrical equipment, remote process equipment, embedded instrument and control cables, and in-cell jumper cables used in the facility. This program is based on the electronic characterization and diagnostic (ECAD) system which was modified to include process response analysis and to meet rigid Department of Energy equipment requirements. The system consists of computer-automated, state-of-the-art electronics. The data that are gathered are stored in a computerized database for analysis, trending, and troubleshooting. It is anticipated that the data which are gathered and trended will aid in life extension for the facility.

  3. Efficacy and safety of maintenance erlotinib in Asian patients with advanced non-small-cell lung cancer: a subanalysis of the phase III, randomized SATURN study.

    PubMed

    Wu, Yi-Long; Kim, Joo-Hang; Park, Keunchil; Zaatar, Adel; Klingelschmitt, Gaëlle; Ng, Christina

    2012-08-01

    Maintenance therapy, commenced immediately after the completion of first-line chemotherapy, is a promising strategy for improving treatment outcomes in patients with non-small-cell lung cancer (NSCLC). The global phase III SequentiAl Tarceva in UnResectable NSCLC (SATURN) study evaluated the efficacy and safety of the epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor erlotinib as maintenance treatment in NSCLC patients without progression after first-line chemotherapy. We report a retrospective subanalysis of Asian patients enrolled in SATURN. Patients with advanced NSCLC with no evidence of progression after four cycles of chemotherapy were randomized to receive erlotinib 150 mg/day or placebo, until progressive disease or limiting toxicity. The co-primary endpoints of SATURN were progression-free survival (PFS) in all patients and in those with positive EGFR immunohistochemistry (IHC) status. Secondary endpoints included overall survival (OS), disease control rate, safety, quality of life (QoL) and biomarker analyses. In total, 126 patients from East and South-East Asian centers were randomized (14% of the intent-to-treat population): 88 from Korea, 28 from China and 10 from Malaysia; one patient was excluded from this analysis due to Indian ethnicity. PFS was significantly prolonged in the erlotinib treatment arm, both overall (hazard ratio [HR]: 0.57; p=0.0067) and in patients with EGFR IHC-positive disease (HR=0.50; p=0.0057). There was a trend towards an increase in OS, which reached statistical significance in the EGFR IHC-positive subgroup (p=0.0233). The overall response rate was significantly higher with erlotinib compared with placebo (24% versus 5%; p=0.0025). Erlotinib was generally well tolerated and had no negative impact on QoL in this subpopulation. The most common treatment-related adverse events were rash, diarrhea and pruritus. Erlotinib was effective and well tolerated in Asian patients, producing benefits consistent with those

  4. Advisory Council Member.

    ERIC Educational Resources Information Center

    Illinois State Board of Vocational Education and Rehabilitation, Springfield. Div. of Vocational and Technical Education.

    The pamphlet is directed toward the new member of a career education advisory council. It explains why advisory councils are needed and why an individual should join one. An advisory council is defined as a group of persons selected to collectively advise regarding career education efforts within the community, whose members are predominantly from…

  5. 77 FR 48610 - Advisory Committee on Disability Compensation, Notice of Meeting Amendment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-14

    ... AFFAIRS Advisory Committee on Disability Compensation, Notice of Meeting Amendment The Department of... Advisory Committee on Disability Compensation will meet on August 20-21, 2012, at the St. Regis Hotel, 923... on the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities. The...

  6. Advanced manpower and time saving testing concept for development, production, and maintenance of electro-optical systems

    NASA Astrophysics Data System (ADS)

    Cabib, Dario; Buckwald, R. A.; Nirkin, Shimon; Lavi, Moshe; Neria, Oded; Ben Yaakov, Claudia; Tzafrir, Efraim; Blau, Moshe; Dolev, Jacob

    2006-05-01

    In all stages of an electro-optics system's life, development, production, and periodic maintenance, a large amount of manpower and time is devoted to testing. Each subsystem separately as well as the system as a whole are tested by a PC controlled test system, which consists of hardware for creation of the appropriate stimuli, and software for tests management and control. A very considerable portion of this manpower and time is devoted by the system manufacturer to configure the test routines, to manually input certain parameter values of the Unit Under Test (UUT) at predefined test nodes, and to reconfigure these routines from time to time, as the needs change during the system's life time. CI has developed the CTE (CI Test Executive), a software package which is a breakthrough in saving manpower and time devoted to electro-optics system testing. The new concept is based on: 1. The CTE can communicate directly with any UUT able to communicate with the outside world through a known protocol, to automatically set the UUT parameters before testing, 2. The user can more easily reconfigure the communication with the UUT through a provided special Excel file, without the help of the test system manufacturer, 3. The interface screen is automatically reconfigured every time the Excel file is changed to build the new test routine, 4. The CTE can simulate the test system stimuli with error injection capability, and simultaneously monitor communication and other hardware functions, 5. Test "verification" signals are provided on-line for the convenience and time saving of the test operator.

  7. Computer Technology and Maintenance Curriculum. Final Report.

    ERIC Educational Resources Information Center

    Manchester Community Coll., CT.

    A project was conducted by Manchester Community College and Howell Cheney Vocational Technical School in Connecticut to develop a joint curriculum for a two-year computer technology and maintenance program. During the year the project was conducted, a high technology advisory council was formed, consisting of industry and faculty representatives…

  8. Building Maintenance. Florida Vocational Program Guide.

    ERIC Educational Resources Information Center

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    This program guide identifies primary concerns in the organization, operation, and evaluation of a building maintenance program. It is designed for local school district and community college administrators, instructors, program advisory committees, and regional coordinating councils. The guide begins with the Dictionary of Occupational Titles…

  9. The Application of Advanced Cultivation Techniques in the Long Term Maintenance of Space Flight Plant Biological Systems

    NASA Technical Reports Server (NTRS)

    Heyenga, A. G.

    2003-01-01

    The development of the International Space Station (ISS) presents extensive opportunities for the implementation of long duration space life sciences studies. Continued attention has been placed in the development of plant growth chamber facilities capable of supporting the cultivation of plants in space flight microgravity conditions. The success of these facilities is largely dependent on their capacity to support the various growth requirements of test plant species. The cultivation requirements for higher plant species are generally complex, requiring specific levels of illumination, temperature, humidity, water, nutrients, and gas composition in order to achieve normal physiological growth and development. The supply of water, nutrients, and oxygen to the plant root system is a factor, which has proven to be particularly challenging in a microgravity space flight environment. The resolution of this issue is particularly important for the more intensive crop cultivation of plants envisaged in Nasa's advanced life support initiative. BioServe Space Technologies is a NASA, Research Partnership Center (RPC) at the University of Colorado, Boulder. BioServe has designed and operated various space flight plant habitat systems, and placed specific emphasis on the development and enhanced performance of subsystem components such as water and nutrient delivery, illumination, gas exchange and atmosphere control, temperature and humidity control. The further development and application of these subsystems to next generation habitats is of significant benefit and contribution towards the development of both the Space Plant biology and the Advanced Life Support Programs. The cooperative agreement between NASA Ames Research center and BioServe was established to support the further implementation of advanced cultivation techniques and protocols to plant habitat systems being coordinated at NASA Ames Research Center. Emphasis was placed on the implementation of passive

  10. The Application of Advanced Cultivation Techniques in the Long Term Maintenance of Space Flight Plant Biological Systems

    NASA Technical Reports Server (NTRS)

    Heyenga, A. G.

    2003-01-01

    The development of the International Space Station (ISS) presents extensive opportunities for the implementation of long duration space life sciences studies. Continued attention has been placed in the development of plant growth chamber facilities capable of supporting the cultivation of plants in space flight microgravity conditions. The success of these facilities is largely dependent on their capacity to support the various growth requirements of test plant species. The cultivation requirements for higher plant species are generally complex, requiring specific levels of illumination, temperature, humidity, water, nutrients, and gas composition in order to achieve normal physiological growth and development. The supply of water, nutrients, and oxygen to the plant root system is a factor, which has proven to be particularly challenging in a microgravity space flight environment. The resolution of this issue is particularly important for the more intensive crop cultivation of plants envisaged in Nasa's advanced life support initiative. BioServe Space Technologies is a NASA, Research Partnership Center (RPC) at the University of Colorado, Boulder. BioServe has designed and operated various space flight plant habitat systems, and placed specific emphasis on the development and enhanced performance of subsystem components such as water and nutrient delivery, illumination, gas exchange and atmosphere control, temperature and humidity control. The further development and application of these subsystems to next generation habitats is of significant benefit and contribution towards the development of both the Space Plant biology and the Advanced Life Support Programs. The cooperative agreement between NASA Ames Research center and BioServe was established to support the further implementation of advanced cultivation techniques and protocols to plant habitat systems being coordinated at NASA Ames Research Center. Emphasis was placed on the implementation of passive

  11. Industrial Maintenance Strategies

    SciTech Connect

    Sajjad Akbar

    2006-07-01

    Industrial plants have become more complex due to technological advancement. This has made the task of maintenance more difficult. The maintenance costs in terms of resources and downtime loss are so high that maintenance function has become a critical factor in a plant's profitability. Industry should devote as much forethought to the management of maintenance function as to production. Maintenance has grown from an art to a precise, technical engineering science. Planning, organizing scheduling and control of maintenance using modern techniques pays dividends in the form of reduced costs and increased reliability. The magnitude and the dimension of maintenance have multiplied due to development in the engineering technologies. Production cost and capacities are directly affected by the breakdown time. Total operating cost including the maintenance cost plays an important role in replacement dimension. The integrated system approach would bring forth the desired results of high maintenance standards. The standards once achieved and sustained, would add to the reliability of the plan and relieve heavy stresses and strains on the engineering logistic support. (author)

  12. Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer.

    PubMed

    Brugger, Wolfram; Triller, Nadja; Blasinska-Morawiec, Maria; Curescu, Stefan; Sakalauskas, Raimundas; Manikhas, Georgy Moiseevich; Mazieres, Julien; Whittom, Renaud; Ward, Carol; Mayne, Karen; Trunzer, Kerstin; Cappuzzo, Federico

    2011-11-01

    The phase III, randomized, placebo-controlled Sequential Tarceva in Unresectable NSCLC (SATURN; BO18192) study found that erlotinib maintenance therapy extended progression-free survival (PFS) and overall survival in patients with advanced non-small-cell lung cancer (NSCLC) who had nonprogressive disease following first-line platinum-doublet chemotherapy. This study included prospective analysis of the prognostic and predictive value of several biomarkers. Mandatory diagnostic tumor specimens were collected before initiating first-line chemotherapy and were tested for epidermal growth factor receptor (EGFR) protein expression by using immunohistochemistry (IHC), EGFR gene copy number by using fluorescent in situ hybridization (FISH), and EGFR and KRAS mutations by using DNA sequencing. An EGFR CA simple sequence repeat in intron 1 (CA-SSR1) polymorphism was evaluated in blood. All 889 randomly assigned patients provided tumor samples. EGFR IHC, EGFR FISH, KRAS mutation, and EGFR CA-SSR1 repeat length status were not predictive for erlotinib efficacy. A profound predictive effect on PFS of erlotinib relative to placebo was observed in the EGFR mutation-positive subgroup (hazard ratio [HR], 0.10; P < .001). Significant PFS benefits were also observed with erlotinib in the wild-type EGFR subgroup (HR, 0.78; P = .0185). KRAS mutation status was a significant negative prognostic factor for PFS. This large prospective biomarker study found that patients with activating EGFR mutations derive the greatest PFS benefit from erlotinib maintenance therapy. No other biomarkers were predictive for outcomes with erlotinib, although the study was not powered for clinical outcomes in biomarker subgroups other than EGFR IHC-positive [corrected]. KRAS mutations were prognostic for reduced PFS. The study demonstrated the feasibility of prospective tissue collection for biomarker analyses in NSCLC.

  13. 77 FR 27078 - Cancellation of May 8, 2012, Meeting of the Wekiva River System Advisory Management Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ... National Park Service Cancellation of May 8, 2012, Meeting of the Wekiva River System Advisory Management... Wekiva River System Advisory Management Committee previously announced in the Federal Register, April 18... decisions and steps that advance the Wekiva River System Advisory Management Committee towards its...

  14. Cost-effectiveness of continuation maintenance pemetrexed after cisplatin and pemetrexed chemotherapy for advanced nonsquamous non-small-cell lung cancer: estimates from the perspective of the Chinese health care system.

    PubMed

    Zeng, Xiaohui; Peng, Liubao; Li, Jianhe; Chen, Gannong; Tan, Chongqing; Wang, Siying; Wan, Xiaomin; Ouyang, Lihui; Zhao, Ziying

    2013-01-01

    Continuation maintenance treatment with pemetrexed is approved by current clinical guidelines as a category 2A recommendation after induction therapy with cisplatin and pemetrexed chemotherapy (CP strategy) for patients with advanced nonsquamous non-small-cell lung cancer (NSCLC). However, the cost-effectiveness of the treatment remains unclear. We completed a trial-based assessment, from the perspective of the Chinese health care system, of the cost-effectiveness of maintenance pemetrexed treatment after a CP strategy for patients with advanced nonsquamous NSCLC. A Markov model was developed to estimate costs and benefits. It was based on a clinical trial that compared continuation maintenance pemetrexed therapy plus best supportive care (BSC) versus placebo plus BSC after a CP strategy for advanced nonsquamous NSCLC. Sensitivity analyses were conducted to assess the stability of the model. The model base case analysis suggested that continuation maintenance pemetrexed therapy after a CP strategy would increase benefits in a 1-, 2-, 5-, or 10-year time horizon, with incremental costs of $183,589.06, $126,353.16, $124,766.68, and $124,793.12 per quality-adjusted life-year gained, respectively. The most sensitive influential variable in the cost-effectiveness analysis was the utility of the progression-free survival state, followed by proportion of patients with postdiscontinuation therapy in both arms, proportion of BSC costs for PFS versus progressed survival state, and cost of pemetrexed. Probabilistic sensitivity analysis indicated that the cost-effective probability of adding continuation maintenance pemetrexed therapy to BSC was zero. One-way and probabilistic sensitivity analyses revealed that the Markov model was robust. Continuation maintenance of pemetrexed after a CP strategy for patients with advanced nonsquamous NSCLC is not cost-effective based on a recent clinical trial. Decreasing the price or adjusting the dosage of pemetrexed may be a better option

  15. Powerful drivers for maintenance.

    PubMed

    Mason, Steve

    2013-10-01

    A UPS system is the central building block of a Power Continuity Plan in medical facilities, but such equipment requires careful maintenance to continue fulfilling its vital role in delivering power resilience, and avoid catastrophic downtime, and potentially tens of thousands of pounds in costs to rectify the issues caused by poor maintenance. In our latest technical guidance article, Steve Mason, MD at Bender UK, one of the leading providers of isolated power supplies, theatre control panels, UPS systems, and Steris surgical products, and a turnkey provider of solutions for safe handling of electrical power and advanced provision of critical care products, examines some of the issue surrounding UPS maintenance.

  16. Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice.

    PubMed

    Fineschi, Silvia; De Cunto, Giovanna; Facchinetti, Fabrizio; Civelli, Maurizio; Imbimbo, Bruno P; Carnini, Chiara; Villetti, Gino; Lunghi, Benedetta; Stochino, Stefania; Gibbons, Deena L; Hayday, Adrian; Lungarella, Giuseppe; Cavarra, Eleonora

    2013-02-01

    The role of the receptor for advanced glycation end products (RAGE) in promoting the inflammatory response through activation of NF-κB pathway is well established. Recent findings indicate that RAGE may also have a regulative function in apoptosis, as well as in cellular proliferation, differentiation, and adhesion. Unlike other organs, lung tissue in adulthood and during organ development shows relatively high levels of RAGE expression. Thus a role for the receptor in lung organogenesis and homeostasis may be proposed. To evaluate the role of RAGE in lung development and adult lung homeostasis, we generated hemizygous and homozygous transgenic mice overexpressing human RAGE, and analyzed their lungs from the fourth postnatal day to adulthood. Moderate RAGE hyperexpression during lung development influenced secondary septation, resulting in an impairment of alveolar morphogenesis and leading to significant changes in morphometric parameters such as airspace number and the size of alveolar ducts. An increase in alveolar cell apoptosis and a decrease in cell proliferation were demonstrated by the terminal deoxy-nucleotidyltransferase-mediated dUTP nick end labeling reaction, active caspase-3, and Ki-67 immunohistochemistry. Alterations in elastin organization and deposition and in TGF-β expression were observed. In homozygous mice, the hyperexpression of RAGE resulted in histological changes resembling those changes characterizing human bronchopulmonary dysplasia (BPD). RAGE hyperexpression in the adult lung is associated with an increase of the alveolar destructive index and persistent inflammatory status leading to "destructive" emphysema. These results suggest an important role for RAGE in both alveolar development and lung homeostasis, and open new doors to working hypotheses on the pathogenesis of BPD and chronic obstructive pulmonary disease.

  17. 75 FR 10760 - 2010 Census Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ...The Bureau of the Census (Census Bureau) is giving notice of a meeting of the 2010 Census Advisory Committee. The Committee will address policy, research, and technical issues related to 2010 Decennial Census Programs and the American Community Survey. Last- minute changes to the agenda are possible, which could prevent giving advance notification of schedule...

  18. Advanced Communications Technology Satellite high burst rate link evaluation terminal experiment control and monitor software maintenance manual, version 1.0

    NASA Technical Reports Server (NTRS)

    Reinhart, Richard C.

    1992-01-01

    The Experiment Control and Monitor (EC&M) software was developed at NASA Lewis Research Center to support the Advanced Communications Technology Satellite (ACTS) High Burst Rate Link Evaluation Terminal (HBR-LET). The HBR-LET is an experimenter's terminal to communicate with the ACTS for various investigations by government agencies, universities, and industry. The EC&M software is one segment of the Control and Performance Monitoring (C&PM) software system of the HBR-LET. The EC&M software allows users to initialize, control, and monitor the instrumentation within the HBR-LET using a predefined sequence of commands. Besides instrument control, the C&PM software system is also responsible for computer communication between the HBR-LET and the ACTS NASA Ground Station and for uplink power control of the HBR-LET to demonstrate power augmentation during rain fade events. The EC&M Software User's Guide, Version 1.0 (NASA-CR-189160) outlines the commands required to install and operate the EC&M software. Input and output file descriptions, operator commands, and error recovery procedures are discussed in the document. The EC&M Software Maintenance Manual, Version 1.0 (NASA-CR-189161) is a programmer's guide that describes current implementation of the EC&M software from a technical perspective. An overview of the EC&M software, computer algorithms, format representation, and computer hardware configuration are included in the manual.

  19. A randomized, phase 2 study comparing pemetrexed plus best supportive care versus best supportive care as maintenance therapy after first-line treatment with pemetrexed and cisplatin for advanced, non-squamous, non-small cell lung cancer.

    PubMed

    Mubarak, Nabil; Gaafar, Rabab; Shehata, Samir; Hashem, Tarek; Abigeres, Dani; Azim, Hamdy A; El-Husseiny, Gamal; Al-Husaini, Hamed; Liu, Zhixin

    2012-09-24

    Maintenance therapy for non-small cell lung cancer (NSCLC) aims to extend disease control after first-line chemotherapy with active and well-tolerated agents. The utility of continuation maintenance therapy requires further research. This multicenter, randomized, phase 2 study compared continuation maintenance therapy with pemetrexed (500 mg/m2 every 21 days) and best supportive care (BSC) versus BSC alone in patients with advanced, non-squamous NSCLC who had not progressed after 4 cycles of induction chemotherapy with pemetrexed (500 mg/m2) and cisplatin (75 mg/m2). The primary endpoint was progression-free survival (PFS) from randomization, was analyzed using a Cox model, stratified for the tumor response at the end of induction therapy, at a one-sided alpha of 0.2. Secondary endpoints: response and disease control rates, overall survival (OS), one year survival rates, and treatment-emergent adverse events (TEAEs). A total of 106 patients commenced induction therapy, of whom 55 patients were randomized to maintenance pemetrexed/BSC (n = 28) or BSC (n = 27). Although the median PFS time for maintenance phase for both arms was 3.2 months, the one-sided p-value for the PFS HR comparison was less than the prespecified limit of 0.2 (HR = 0.76, two-sided 95% confidence interval [CI]: 0.42 to 1.37; one-sided p-value = 0.1815), indicating that PFS was sufficiently long in the pemetrexed/BSC arm to warrant further investigation. Similar PFS results were observed for the overall study period (induction plus maintenance) and when the PFS analysis was adjusted for sex, baseline disease stage, and the ECOG PS prior to randomization. The median OS for the maintenance phase was 12.2 months (95%CI: 5.6 to 20.6) for the pemetrexed/BSC arm and 11.8 months (95% CI: 6.3 to 25.6) for BSC arm. The one-year survival probabilities were similar for both arms for the maintenance phase and the overall study period. Both the induction and continuation

  20. Predicting and prioritizing maintenance for concrete structures

    SciTech Connect

    Hertlein, B.H. )

    1991-06-01

    Using nondestructive testing of concrete structures to predict maintenance needs can help schedule maintenance work in advance and prevent unexpected shutdowns. Nondestructive testing methods are described and development of a testing program is discussed.

  1. 78 FR 40144 - Governmentwide Travel Advisory Committee (GTAC); Upcoming Public Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-03

    ... ADMINISTRATION Governmentwide Travel Advisory Committee (GTAC); Upcoming Public Advisory Committee Meeting AGENCY... Governmentwide Travel Advisory Committee (GTAC) (the Committee), is a Federal Advisory Committee established in..., Designated Federal Officer (DFO), Governmentwide Travel Advisory Committee (GTAC), Office of...

  2. 77 FR 74099 - Reestablishment of Advisory Group

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-12

    .... Reestablishing the Advisory Group on Prevention, Health Promotion, and Integrative and Public Health. The Advisory Group on Prevention, Health Promotion, and Integrative and Public Health (Advisory Group), as...

  3. A Phase III Clinical Trial of the Epidermal Growth Factor Vaccine CIMAvax-EGF as Switch Maintenance Therapy in Advanced Non-Small Cell Lung Cancer Patients.

    PubMed

    Rodriguez, Pedro C; Popa, Xitllaly; Martínez, Odeth; Mendoza, Silvia; Santiesteban, Eduardo; Crespo, Tatiana; Amador, Rosa M; Fleytas, Ricardo; Acosta, Soraida C; Otero, Yanine; Romero, Gala N; de la Torre, Ana; Cala, Mireysi; Arzuaga, Lina; Vello, Loisel; Reyes, Delmairis; Futiel, Niurka; Sabates, Teresa; Catala, Mauricio; Flores, Yoanna I; Garcia, Beatriz; Viada, Carmen; Lorenzo-Luaces, Patricia; Marrero, Maria A; Alonso, Liuba; Parra, Jenelin; Aguilera, Nadia; Pomares, Yaisel; Sierra, Patricia; Rodríguez, Gryssell; Mazorra, Zaima; Lage, Agustin; Crombet, Tania; Neninger, Elia

    2016-08-01

    EGFR is a well-validated target for patients with non-small cell lung cancer (NSCLC). CIMAvax-EGF is a therapeutic cancer vaccine composed of human recombinant EGF conjugated to a carrier protein and Montanide ISA51 as adjuvant. The vaccine is intended to induce antibodies against self EGFs that block EGF-EGFR interaction. To evaluate overall survival, safety, immunogenicity, and EGF concentration in serum after CIMAvax-EGF, a randomized phase III trial was done in patients with advanced NSCLC. Four to 6 weeks after first-line chemotherapy, 405 patients with stage IIIB/IV NSCLC were randomly assigned to a vaccine group, which received CIMAvax-EGF or a control group, treated with best supportive care. Long-term vaccination was very safe. Most frequent adverse reactions were grade 1 or 2 injection-site pain, fever, vomiting, and headache. Vaccination induced anti-EGF antibodies and decreased serum EGF concentration. In the safety population, median survival time (MST) was 10.83 months in the vaccine arm versus 8.86 months in the control arm. These differences were not significant according the standard log rank (HR, 0.82; P = 0.100), but according a weighted log rank (P = 0.04) that was applied once the nonproportionality of the HR was verified. Survival benefit was significant (HR, 0.77; P = 0.036) in the per-protocol setting (patients receiving at least four vaccine doses): MST was 12.43 months for the vaccine arm versus 9.43 months for the control arm. MST was higher (14.66 months) for vaccinated patients with high EGF concentration at baseline. Switch maintenance with CIMAvax-EGF was well tolerated and significantly increased MST of patients that completed induction vaccination. Baseline EGF concentration predicted survival benefit. Clin Cancer Res; 22(15); 3782-90. ©2016 AACR. ©2016 American Association for Cancer Research.

  4. Advisory Committee Handbook.

    ERIC Educational Resources Information Center

    Black Hawk Coll., Moline, IL.

    An advisory committee is generally comprised of persons outside the education profession who have specialized knowledge in a given area. The committee advises, makes recommendations, and gives service to the college and its students, instructors, and administrators. At Black Hawk College, there are four types of advisory committees: community,…

  5. Scheduling Advisory. Research Brief

    ERIC Educational Resources Information Center

    Muir, Mike

    2005-01-01

    More and more high schools are implementing Advisory programs for a variety of reasons: personalization, academics & study skills, life success skills, self-knowledge, addressing the concern about students feeling "lost" in the high school setting, first line of contact for the parents, and portfolios. But finding a way to schedule advisory can…

  6. Preventative Maintenance.

    ERIC Educational Resources Information Center

    Migliorino, James

    Boards of education must be convinced that spending money up front for preventive maintenance will, in the long run, save districts' tax dollars. A good program of preventive maintenance can minimize disruption of service; reduce repair costs, energy consumption, and overtime; improve labor productivity and system equipment reliability; handle…

  7. Preventative Maintenance.

    ERIC Educational Resources Information Center

    Migliorino, James

    Boards of education must be convinced that spending money up front for preventive maintenance will, in the long run, save districts' tax dollars. A good program of preventive maintenance can minimize disruption of service; reduce repair costs, energy consumption, and overtime; improve labor productivity and system equipment reliability; handle…

  8. Maintenance Downtime

    Atmospheric Science Data Center

    2013-07-10

    ... will be unavailable March 5, 2013 8:00 am to 5:00 pm due to database maintenance. Date(s):  Tuesday, March 5, 2013 ... will be unavailable March 5, 2013 8:00 am to 5:00 pm due to database maintenance. ...

  9. Maintenance Budgeting.

    ERIC Educational Resources Information Center

    Smith, J. McCree

    Three methods for the preparation of maintenance budgets are discussed--(1) a traditional method, inconclusive and obsolete, based on gross square footage, (2) the formula approach method based on building classification (wood-frame, masonry-wood, masonry-concrete) with maintenance cost factors for each type plus custodial service rates by type of…

  10. Software Maintenance.

    ERIC Educational Resources Information Center

    Cannon, Glenn; Jobe, Holly

    Proper cleaning and storage of audiovisual aids is outlined in this brief guide. Materials and equipment needed for first line maintenance are listed, as well as maintenance procedures for records, audio and video tape, film, filmstrips, slides, realia, models, prints, graphics, maps, and overhead transparencies. A 15-item quiz on software…

  11. 76 FR 8715 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold...: Office of the Secretary. Please use the title ``Technology Advisory Committee'' in any written...

  12. Double-blind, randomized, phase 2 trial of maintenance sunitinib versus placebo after response to chemotherapy in patients with advanced urothelial carcinoma.

    PubMed

    Grivas, Petros D; Daignault, Stephanie; Tagawa, Scott T; Nanus, David M; Stadler, Walter M; Dreicer, Robert; Kohli, Manish; Petrylak, Daniel P; Vaughn, David J; Bylow, Kathryn A; Wong, Steven G; Sottnik, Joseph L; Keller, Evan T; Al-Hawary, Mahmoud; Smith, David C; Hussain, Maha

    2014-03-01

    Angiogenesis contributes to the progression of urothelial carcinoma (UC). In the current study, the authors investigated the role of maintenance sunitinib in patients with advanced UC. Patients with locally recurrent/metastatic UC and adequate organ function who achieved stable disease or a partial or complete response after 4 to 6 chemotherapy cycles were randomized to sunitinib at a dose of 50 mg/day (28 days on and 14 days off) or placebo. The primary endpoint was the 6-month progression rate. Secondary endpoints were safety, survival, change in serum vascular endothelial growth factor (VEGF)/soluble VEGF receptor-2 (sVEGFR2), and the activity of sunitinib in patients who developed disease progression while receiving placebo. A total of 38 eligible patients per treatment arm were required to select better therapy with 90% probability (α = .05). A total of 54 eligible patients were randomized to either the sunitinib arm (26 patients) or the placebo arm (28 patients). The median number of cycles received was 2 cycles per treatment arm. The most common grade 3 to 4 adverse events (graded according to version 3.0 of the National Cancer Institute Common Terminology Criteria for Adverse Events) among patients receiving sunitinib were thrombocytopenia, diarrhea, mucositis, fatigue, and hypertension. There were no grade 3 or 4 adverse events noted among > 5% of patients receiving placebo. The 6-month progression rate was 72% versus 64%. The median progression-free survival (PFS) was 2.9 months (range, 0.5 months-32.5 months) versus 2.7 months (range, 0.8 months -65 months) for the sunitinib versus placebo arms, respectively. Patients receiving placebo were found to have no changes in their serum VEGF/sVEGFR2 levels over time. Patients treated with sunitinib had no significant change in their VEGF level, but the sVEGFR2 level significantly decreased after cycles 1 and 2 (P < .0001) and at the time of disease progression (P = .0002). A baseline VEGF level that was

  13. Enhanced Aircraft Platform Availability Through Advanced Maintenance Concepts and Technologies (Amelioration de la Disponibilite des Plateformes D’Aeronefs par L’Utilisation des Technologies et des Concepts Evolues de Maintenance)

    DTIC Science & Technology

    2011-06-01

    David Elford MOD DPA-DLO United Kingdom Mr. Richard Eustace Defence Science and Technology Organisation (DSTO) Australia Oberstleut nant Dirk...d’équipements de soutien qui peuvent être utilisées pour réduire le besoin en maintenance et les immobilisations associées. Le courant dominant de la R&D en...Defence Materiel in Operational Condition). In a statement to the Defence Commission of the French National Assembly in 2005 [12], General Richard

  14. 77 FR 13131 - Advisory Committees; Filing of Closed Meeting Reports

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-05

    ... Research Allergenic Products Advisory Committee Blood Products Advisory Committee Cellular, Tissue and Gene Therapies Advisory Committee Vaccines and Related Biological Products Advisory Committee Center for Drug...

  15. 75 FR 8176 - U.S. Advisory Commission on Public Diplomacy; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-23

    .... Advisory Commission on Public Diplomacy; Notice of Meeting The U.S. Advisory Commission on Public Diplomacy... inclement weather) at the same location. The Commissioners will discuss public diplomacy issues, including interagency collaboration in advancing U.S. government public diplomacy efforts. The Commission is a...

  16. 77 FR 64563 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... COMMISSION Advisory Committee on Reactor Safeguards; Notice of Meeting In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor... the Advanced Boiling Water Reactor (ABWR) Design for South Texas Project Units 3 and 4 (STP 3 and...

  17. 78 FR 18375 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... COMMISSION Advisory Committee on Reactor Safeguards; Notice of Meeting In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor... the Advanced Boiling Water Reactor (ABWR) Core Design. Note: A portion of this session may be...

  18. 77 FR 4837 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-31

    ... COMMISSION Advisory Committee on Reactor Safeguards; Notice of Meeting In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor... Approach for Reviewing Instrumentation and Control (I&C) for the mPower and Other Advanced Reactors...

  19. 76 FR 23340 - Advisory Committee on Reactor Safeguards; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-26

    ... COMMISSION Advisory Committee on Reactor Safeguards; Notice of Meeting In accordance with the purposes of Sections 29 and 182b of the Atomic Energy Act (42 U.S.C. 2039, 2232b), the Advisory Committee on Reactor...:30 a.m.: Advanced Reactor Research Plan (Open/Closed)--The Committee will hear presentations by...

  20. 78 FR 9689 - Notification of a Public Meeting of the Chartered Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-11

    ... research that integrates advances in molecular biology, chemistry and innovative computer science to more... AGENCY Notification of a Public Meeting of the Chartered Science Advisory Board AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The Environmental Protection Agency (EPA) Science Advisory...

  1. 78 FR 47409 - Meeting of the California Desert District Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-05

    ... Bureau of Land Management Meeting of the California Desert District Advisory Council SUMMARY: Notice is hereby given, in accordance with Public Laws 92-463 and 94-579, that the California Desert District... be filed in advance of the meeting for the California Desert District Advisory Council, c/o Bureau...

  2. Doublet chemotherapy with cisplatin and pemetrexed is associated with a favorable outcome in patients with advanced non-squamous non-small-cell lung cancer who are eligible for bevacizumab and maintenance therapy

    PubMed Central

    Nakashima, Kazuhisa; Murakami, Haruyasu; Omori, Shota; Wakuda, Kazushige; Ono, Akira; Kenmotsu, Hirotsugu; Naito, Tateaki; Endo, Masahiro; Takahashi, Toshiaki

    2016-01-01

    The previous AVAPERL trial demonstrated that induction therapy with first-line cisplatin (CDDP), pemetrexed (PEM) and bevacizumab (BEV), followed by continuation maintenance therapy with PEM+BEV, improved the progression-free survival (PFS) and overall survival (OS) compared with BEV alone (median PFS, 10.2 vs. 6.6 months and median OS, 19.8 vs. 15.9 months, respectively) in patients with advanced non-squamous non-small-cell lung cancer (non-Sq NSCLC). However, those findings were based on selected patients who were eligible for BEV and maintenance therapy. To assess the efficacy of CDDP+PEM as first-line therapy in selected patients depending on their eligibility for BEV and maintenance therapy, consecutive patients with non-Sq NSCLC who received first-line chemotherapy with CDDP+PEM at the Shizuoka Cancer Center (Shizuoka, Japan) between July, 2009 and December, 2013 were retrospectively reviewed. A total of 160 patients were assessed, including 92 who were eligible and 68 who were not eligible for BEV treatment. In the BEV-eligible group, CDDP+PEM treatment followed by maintenance PEM exhibited significantly superior efficacy compared with that in the BEV-ineligible group (median PFS, 5.8 vs. 4.8 months, respectively, P=0.013; and median OS, 21.3 vs. 12.6 months, respectively, P=0.0025). In the BEV-eligible group, 60 patients were suitable for maintenance therapy with PEM (group A) and 32 patients were unsuitable (group B). In the BEV-ineligible group, 31 patients were suitable for maintenance therapy with PEM (group C) and 37 patients were unsuitable (group D). In group A, the median PFS and OS were 6.9 and 31.8 months, respectively, compared with 2.4 and 10.5 months in group B, 6.1 and 18.5 months in group C, and 2.8 and 7.7 months in group D. The PFS and OS in group A were significantly better compared with those in the other groups. Thus, the PFS and OS with CDDP+PEM were favorable among patients with advanced non-Sq NSCLC who were eligible for BEV and

  3. Doublet chemotherapy with cisplatin and pemetrexed is associated with a favorable outcome in patients with advanced non-squamous non-small-cell lung cancer who are eligible for bevacizumab and maintenance therapy.

    PubMed

    Nakashima, Kazuhisa; Murakami, Haruyasu; Omori, Shota; Wakuda, Kazushige; Ono, Akira; Kenmotsu, Hirotsugu; Naito, Tateaki; Endo, Masahiro; Takahashi, Toshiaki

    2016-11-01

    The previous AVAPERL trial demonstrated that induction therapy with first-line cisplatin (CDDP), pemetrexed (PEM) and bevacizumab (BEV), followed by continuation maintenance therapy with PEM+BEV, improved the progression-free survival (PFS) and overall survival (OS) compared with BEV alone (median PFS, 10.2 vs. 6.6 months and median OS, 19.8 vs. 15.9 months, respectively) in patients with advanced non-squamous non-small-cell lung cancer (non-Sq NSCLC). However, those findings were based on selected patients who were eligible for BEV and maintenance therapy. To assess the efficacy of CDDP+PEM as first-line therapy in selected patients depending on their eligibility for BEV and maintenance therapy, consecutive patients with non-Sq NSCLC who received first-line chemotherapy with CDDP+PEM at the Shizuoka Cancer Center (Shizuoka, Japan) between July, 2009 and December, 2013 were retrospectively reviewed. A total of 160 patients were assessed, including 92 who were eligible and 68 who were not eligible for BEV treatment. In the BEV-eligible group, CDDP+PEM treatment followed by maintenance PEM exhibited significantly superior efficacy compared with that in the BEV-ineligible group (median PFS, 5.8 vs. 4.8 months, respectively, P=0.013; and median OS, 21.3 vs. 12.6 months, respectively, P=0.0025). In the BEV-eligible group, 60 patients were suitable for maintenance therapy with PEM (group A) and 32 patients were unsuitable (group B). In the BEV-ineligible group, 31 patients were suitable for maintenance therapy with PEM (group C) and 37 patients were unsuitable (group D). In group A, the median PFS and OS were 6.9 and 31.8 months, respectively, compared with 2.4 and 10.5 months in group B, 6.1 and 18.5 months in group C, and 2.8 and 7.7 months in group D. The PFS and OS in group A were significantly better compared with those in the other groups. Thus, the PFS and OS with CDDP+PEM were favorable among patients with advanced non-Sq NSCLC who were eligible for BEV and

  4. 76 FR 22395 - Federal Advisory Committee Act; Open Internet Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ... COMMISSION Federal Advisory Committee Act; Open Internet Advisory Committee AGENCY: Federal Communications... ``Open Internet Advisory Committee'' (hereinafter ``the Committee''), is being established. FOR FURTHER... Internet rules (available at...

  5. Environmental Laboratory Advisory Board

    EPA Pesticide Factsheets

    The Environmental Laboratory Advisory Board (ELAB) was established to provide consensus advice, information and recommendations on issues related to EPA measurement programs, and operation of the national accreditation program

  6. Rockford's Remarkable Advisory Council

    ERIC Educational Resources Information Center

    Mitchell, Brad

    1977-01-01

    Describes the cooperative relationship between the Rockford, Illinois, advisory council and the Comprehensive Employment and Training Act (CETA) staff for Winnebago and Boone Counties and credits this cooperation and community input with CETA's success. (MF)

  7. FIFRA Scientific Advisory Panel

    EPA Pesticide Factsheets

    Experts on the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel provide independent scientific advice to the EPA on a wide range of health and safety issues related to pesticides.

  8. 78 FR 33092 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-03

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications..., this notice advises interested persons that the Federal Communications Commission's (FCC)...

  9. 77 FR 70434 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications..., this notice advises interested persons that the Federal Communications Commission's (FCC) Technological...

  10. 78 FR 67362 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications..., this notice advises interested persons that the Federal Communications Commission's (FCC) Technological...

  11. 77 FR 30289 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-22

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications..., this notice advises interested persons that the Federal Communications Commission's (FCC) Technological...

  12. 76 FR 58513 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Technological Advisory Council AGENCY: Federal Communications..., this notice advises interested persons that the Federal Communications Commission's (FCC) Technological...

  13. Automated Pilot Advisory System

    NASA Technical Reports Server (NTRS)

    Parks, J. L., Jr.; Haidt, J. G.

    1981-01-01

    An Automated Pilot Advisory System (APAS) was developed and operationally tested to demonstrate the concept that low cost automated systems can provide air traffic and aviation weather advisory information at high density uncontrolled airports. The system was designed to enhance the see and be seen rule of flight, and pilots who used the system preferred it over the self announcement system presently used at uncontrolled airports.

  14. Enhanced Aircraft Platform Availability Through Advanced Maintenance Concepts and Technologies (Amelioration de la disponibilite des plateformes d’aeronefs au moyen de concepts de maintenance et de technologies evolues)

    DTIC Science & Technology

    2011-06-01

    was by invitation only. Most of the participants were senior engineers and managers with relevant hands-on experience from industry, the Armed Forces...availability. • Metrics, key performance indicators, and modelling of aircraft availability. • Maintenance/support management concepts and technologies...été entreprises ces quarante dernières années par certaines nations de l’OTAN avec pour objectifs de réduire les coûts et d’améliorer la

  15. A randomized, phase 2 study comparing pemetrexed plus best supportive care versus best supportive care as maintenance therapy after first-line treatment with pemetrexed and cisplatin for advanced, non-squamous, non-small cell lung cancer

    PubMed Central

    2012-01-01

    Background Maintenance therapy for non-small cell lung cancer (NSCLC) aims to extend disease control after first-line chemotherapy with active and well-tolerated agents. The utility of continuation maintenance therapy requires further research. Methods This multicenter, randomized, phase 2 study compared continuation maintenance therapy with pemetrexed (500 mg/m2 every 21 days) and best supportive care (BSC) versus BSC alone in patients with advanced, non-squamous NSCLC who had not progressed after 4 cycles of induction chemotherapy with pemetrexed (500 mg/m2) and cisplatin (75 mg/m2). The primary endpoint was progression-free survival (PFS) from randomization, was analyzed using a Cox model, stratified for the tumor response at the end of induction therapy, at a one-sided alpha of 0.2. Secondary endpoints: response and disease control rates, overall survival (OS), one year survival rates, and treatment-emergent adverse events (TEAEs). Results A total of 106 patients commenced induction therapy, of whom 55 patients were randomized to maintenance pemetrexed/BSC (n = 28) or BSC (n = 27). Although the median PFS time for maintenance phase for both arms was 3.2 months, the one-sided p-value for the PFS HR comparison was less than the prespecified limit of 0.2 (HR = 0.76, two-sided 95% confidence interval [CI]: 0.42 to 1.37; one-sided p-value = 0.1815), indicating that PFS was sufficiently long in the pemetrexed/BSC arm to warrant further investigation. Similar PFS results were observed for the overall study period (induction plus maintenance) and when the PFS analysis was adjusted for sex, baseline disease stage, and the ECOG PS prior to randomization. The median OS for the maintenance phase was 12.2 months (95%CI: 5.6 to 20.6) for the pemetrexed/BSC arm and 11.8 months (95% CI: 6.3 to 25.6) for BSC arm. The one-year survival probabilities were similar for both arms for the maintenance phase and the overall study period. Both the

  16. 78 FR 69991 - Advisory Committee; Veterinary Medicine Advisory Committee; Termination

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 14 Advisory Committee; Veterinary Medicine... Food and Drug Administration (FDA) is announcing the termination of the Veterinary Medicine Advisory Committee. This document removes the Veterinary Advisory Committee from the Agency's list of...

  17. 75 FR 30002 - Federal Advisory Committee; Threat Reduction Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-28

    ... Office of the Secretary Federal Advisory Committee; Threat Reduction Advisory Committee AGENCY... the charter for the Threat Reduction Advisory Committee (hereafter referred to as the Committee). FOR... Acquisition, Technology and Logistics and the Director of the Defense Threat Reduction Agency on the following...

  18. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This report presents the results of the Aerospace Safety Advisory Panel (ASAP) activities during 2002. The format of the report has been modified to capture a long-term perspective. Section II is new and highlights the Panel's view of NASA's safety progress during the year. Section III contains the pivotal safety issues facing NASA in the coming year. Section IV includes the program area findings and recommendations. The Panel has been asked by the Administrator to perform several special studies this year, and the resulting white papers appear in Appendix C. The year has been filled with significant achievements for NASA in both successful Space Shuttle operations and International Space Station (ISS) construction. Throughout the year, safety has been first and foremost in spite of many changes throughout the Agency. The relocation of the Orbiter Major Modifications (OMMs) from California to Kennedy Space Center (KSC) appears very successful. The transition of responsibilities for program management of the Space Shuttle and ISS programs from Johnson Space Center (JSC) to NASA Headquarters went smoothly. The decision to extend the life of the Space Shuttle as the primary NASA vehicle for access to space is viewed by the Panel as a prudent one. With the appropriate investments in safety improvements, in maintenance, in preserving appropriate inventories of spare parts, and in infrastructure, the Space Shuttle can provide safe and reliable support for the ISS for the foreseeable future. Indications of an aging Space Shuttle fleet occurred on more than one occasion this year. Several flaws went undetected in the early prelaunch tests and inspections. In all but one case, the problems were found prior to launch. These incidents were all handled properly and with safety as the guiding principle. Indeed, launches were postponed until the problems were fully understood and mitigating action could be taken. These incidents do, however, indicate the need to analyze the

  19. Building Maintenance and Utilities Management. Florida Vocational Program Guide.

    ERIC Educational Resources Information Center

    University of South Florida, Tampa. Dept. of Adult and Vocational Education.

    This program guide identifies primary concerns in the organization, operation, and evaluation of a building maintenance and utilities management program. It is designed for local school district and community college administrators, instructors, program advisory committees, and regional coordinating councils. The guide begins with the Dictionary…

  20. 76 FR 18757 - Monthly Public Meetings of the Local Government Advisory Committee's Small Community Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-05

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY Monthly Public Meetings of the Local Government Advisory Committee's Small Community Advisory... Advisory Committee Act, the U.S. Environmental Protection Agency's Local Government Advisory...

  1. 76 FR 29752 - The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-23

    ... Technology Management in the Federal Government, and Senior Executive Service (SES) Development and... ADMINISTRATION The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting.... SUMMARY: The President's Management Advisory Board, a Federal Advisory Committee established in...

  2. 67 FR 12587 - NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of the Universe...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2002-03-19

    ... SPACE ADMINISTRATION NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of... Advisory Council, Space Science Advisory Committee, Structure and Evolution of the Universe Subcommittee... Science Enterprise --Structure and Evolution of the Universe Overview: --Budget, Ongoing Programs, Future...

  3. WHC Maintenance

    NASA Image and Video Library

    2009-04-28

    ISS019-E-011464 (28 April 2009) --- Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 19/20 flight engineer, performs in-flight maintenance on the waste and hygiene compartment located in the Destiny laboratory of the International Space Station.

  4. WHC Maintenance

    NASA Image and Video Library

    2009-04-28

    ISS019-E-011471 (28 April 2009) --- Japan Aerospace Exploration Agency (JAXA) astronaut Koichi Wakata, Expedition 19/20 flight engineer, performs in-flight maintenance on the waste and hygiene compartment located in the Destiny laboratory of the International Space Station.

  5. Advisory Technical Skills Committee Manual

    ERIC Educational Resources Information Center

    Barbee, Jim R.

    2005-01-01

    The use of advisory committees is well established in the public school system. The purpose of advisory committees is to provide leadership, guidance and technical assistance to maintain, improve and develop quality career and technical education programs. This manual is written for those planning to form new advisory technical skills committees,…

  6. 75 FR 55365 - Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Joint Subcommittee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Joint Subcommittee The ACRS Subcommittees on Thermal Hydraulics Phenomena; Advanced Boiling Water Reactor (ABWR); and Materials,...

  7. 78 FR 20358 - NASA Advisory Council; Human Exploration and Operations Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ... SPACE ADMINISTRATION NASA Advisory Council; Human Exploration and Operations Committee; Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of meeting. SUMMARY: In accordance with the... Advancement of Science in Space/Status of Research Subcommittee --Status of Exploration Systems...

  8. Single-agent maintenance therapy for advanced non-small cell lung cancer (NSCLC): a systematic review and Bayesian network meta-analysis of 26 randomized controlled trials

    PubMed Central

    Zeng, Xiaoning; Ma, Yuan

    2016-01-01

    Background The benefit of maintenance therapy has been confirmed in patients with non-progressing non-small cell lung cancer (NSCLC) after first-line therapy by many trials and meta-analyses. However, since few head-to-head trials between different regimens have been reported, clinicians still have little guidance on how to select the most efficacious single-agent regimen. Hence, we present a network meta-analysis to assess the comparative treatment efficacy of several single-agent maintenance therapy regimens for stage III/IV NSCLC. Methods A comprehensive literature search of public databases and conference proceedings was performed. Randomized clinical trials (RCTs) meeting the eligible criteria were integrated into a Bayesian network meta-analysis. The primary outcome was overall survival (OS) and the secondary outcome was progression free survival (PFS). Results A total of 26 trials covering 7,839 patients were identified, of which 24 trials were included in the OS analysis, while 23 trials were included in the PFS analysis. Switch-racotumomab-alum vaccine and switch-pemetrexed were identified as the most efficacious regimens based on OS (HR, 0.64; 95% CrI, 0.45–0.92) and PFS (HR, 0.54; 95% CrI, 0.26–1.04) separately. According to the rank order based on OS, switch-racotumomab-alum vaccine had the highest probability as the most effective regimen (52%), while switch-pemetrexed ranked first (34%) based on PFS. Conclusions Several single-agent maintenance therapy regimens can prolong OS and PFS for stage III/IV NSCLC. Switch-racotumomab-alum vaccine maintenance therapy may be the most optimal regimen, but should be confirmed by additional evidence. PMID:27781159

  9. First-line bevacizumab, cisplatin and vinorelbine plus maintenance bevacizumab in advanced non-squamous non-small cell lung cancer chemo-naïve patients.

    PubMed

    Leon, Luis; Vázquez, Sergio; Gracia, José Manuel; Casal, Joaquín; Lazaro, Martín; Firvida, José Luis; Amenedo, Margarita; Santome, Lucia; Macia, Sonia

    2012-07-01

    The aim of this study was to evaluate efficacy and safety of first-line treatment with bevacizumab, cisplatin and vinorelbine and bevacizumab maintenance in non-squamous, non-small cell lung cancer (NSCLC). Forty-nine patients with stage IIIB plus pleural effusion or stage IV NSCLC were included in a Phase II clinical trial. Treatment consisted of 3-week cycles of bevacizumab (15 mg/kg on day 1), cisplatin (80 mg/m(2) on day 1) and vinorelbine (25 mg/m(2) on days 1 and 8). After 6 cycles, non-progressing patients received bevacizumab maintenance therapy. The primary end point was progression-free survival (PFS), calculated using the Kaplan-Meier method. Thirteen (29%) of 45 evaluable patients presented a partial response. PFS and overall survival were 6.0 months (95% confidence interval (CI) 4.5 - 7.5) and 14.7 months (95% CI 8.4 - 21), respectively. Fourteen patients (28%) experienced grade 3 - 4 neutropenia and 7 (14%) experienced febrile neutropenia during the combination treatment. During the maintenance phase, the most frequent grade 3 - 4 adverse event was hypertension. Neither grade 3 - 4 thrombocytopenia nor toxic death was observed. The studied regimen achieved a similar efficacy to other regimens containing platinum doublets. The data provide further evidence that bevacizumab may be used in combination with multiple standard platinum-based doublets in this setting.

  10. Periodontal maintenance.

    PubMed

    Tan, A E S

    2009-09-01

    The main goal of periodontal therapy is to establish an oral environment compatible with periodontal health by the physical disruption of the plaque biofilm and adjunctive chemical means if required. Implicit in this objective is the ongoing requirement of detection and interception of new and recurrent disease, which continues at selected intervals for the life of the dentition after the initial ("active") phase of periodontal treatment. This concept of ongoing periodontal maintenance therapy has been embraced as the mandatory requirement for favourable periodontal outcomes based on institutional clinical trials and in practice-based studies in various parts of the world. This review examines the ramifications of periodontal maintenance therapy based upon a multi-level assessment of logistic issues and risk factors at three levels: (1) The patient level - treatment time; patient attendance compliance; and homecare measures, antiseptics/antibiotics and smoking. (2) The level of the individual tooth - tooth loss; and evaluation of success versus survival. (3) The level of each tooth surface ("site") - probing depth, loss of attachment and bleeding on probing; and changes in clinical attachment levels. In spite of the diversity of studies conducted, there is agreement on the efficacy of periodontal maintenance therapy when compared with studies on untreated populations and in treated cases that were not maintained.

  11. 78 FR 65689 - Technical Mapping Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-01

    ... SECURITY Federal Emergency Management Agency Technical Mapping Advisory Council AGENCY: Federal Emergency... Emergency Management Agency's Technical Mapping Advisory Council. SUMMARY: The Federal Emergency Management Agency (FEMA) is requesting qualified individuals interested in serving on the Technical Mapping Advisory...

  12. 75 FR 42080 - Agricultural Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... COMMISSION Agricultural Advisory Committee Meeting AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of Meeting of Agricultural Advisory Committee. SUMMARY: The CFTC's Agricultural Advisory.... Written statements and requests to make oral statements should be sent to the attention of Agricultural...

  13. 77 FR 51512 - Allegheny Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... Forest Service Allegheny Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Allegheny Resource Advisory Committee will meet in Warren, Pennsylvania. The... conducted: Allegheny Resource Advisory Committee members will solicit and consider project proposals...

  14. 76 FR 12317 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will meet in Thermopolis, Wyoming... Broadway, Thermopolis, Wyoming. FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory...

  15. 76 FR 22672 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will meet in Thermopolis, Wyoming... CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest...

  16. 76 FR 2081 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-12

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Ketchikan Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in Ketchikan..., 3031 Tongass Avenue, Ketchikan, Alaska. Send written comments to Ketchikan Resource Advisory...

  17. 76 FR 41196 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will meet in Thermopolis, Wyoming...: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone National Forest Supervisor's...

  18. 76 FR 3081 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-19

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will hold a conference call on.... FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator,...

  19. 77 FR 43064 - Meeting; Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-23

    ... COMMISSION Meeting; Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (CFTC). ACTION: Notice of emergency meeting of technology advisory committee. SUMMARY: The CFTC announces that on Thursday, July 26, 2012, the CFTC's Technology Advisory Committee (``TAC'') will hold an emergency...

  20. 75 FR 58367 - Technology Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-24

    ... COMMISSION Technology Advisory Committee Meeting AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee...., Washington, DC 20581, attention: Office of the Secretary. Please use the title ``Technology...

  1. 76 FR 776 - Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-06

    ... COMMISSION Technology Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Technology Advisory Committee. SUMMARY: The Technology Advisory Committee will hold...., Washington, DC 20581, attention: Office of the Secretary. Please use the title ``Technology...

  2. 77 FR 47360 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-08

    ... Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee (Committee) will hold a conference call on.... FOR FURTHER INFORMATION CONTACT: Olga Troxel, Resource Advisory Committee Coordinator, Shoshone...

  3. Vocational Technical Advisory Committees: A Guide for Their Effective Use.

    ERIC Educational Resources Information Center

    Alabama State Dept. of Education, Montgomery. Div. of Vocational Education Services.

    Business and industry have been shaken by the explosion of new technology, and scientific and technological advances will continue to have a profound impact on the labor market. Vocational education plays a key role in preparing citizens for jobs. This manual encourages greater use of advisory committees in vocational education programs. Advisory…

  4. International Advisory Councils and Internationalization of Governance: A Qualitative Analysis

    ERIC Educational Resources Information Center

    Mihut, Georgiana; Altbach, Philip G.; Salmi, Jamil

    2016-01-01

    This paper discusses the emergence of international advisory councils (IACs) at universities around the world and introduces the concept of internationalization of governance. Global trends in the field of higher education, such as the quest to create world-class universities and advance in global rankings, the rise of new public management, and…

  5. International Advisory Councils and Internationalization of Governance: A Qualitative Analysis

    ERIC Educational Resources Information Center

    Mihut, Georgiana; Altbach, Philip G.; Salmi, Jamil

    2016-01-01

    This paper discusses the emergence of international advisory councils (IACs) at universities around the world and introduces the concept of internationalization of governance. Global trends in the field of higher education, such as the quest to create world-class universities and advance in global rankings, the rise of new public management, and…

  6. A Placement Advisory Test

    ERIC Educational Resources Information Center

    Hughes, Chris

    2010-01-01

    The primary method of placement at Portland CC (PCC) is the Compass Placement test. For the most part, students are placed correctly, but there are cases when students feel that they have been placed too low. In such cases we use our newly created Placement Advisory Test (PAT) to help us place them appropriately. (Contains 2 figures.)

  7. A Placement Advisory Test

    ERIC Educational Resources Information Center

    Hughes, Chris

    2010-01-01

    The primary method of placement at Portland CC (PCC) is the Compass Placement test. For the most part, students are placed correctly, but there are cases when students feel that they have been placed too low. In such cases we use our newly created Placement Advisory Test (PAT) to help us place them appropriately. (Contains 2 figures.)

  8. The UKCIS Advisory Service.

    ERIC Educational Resources Information Center

    Bingham, Archie

    1979-01-01

    Describes the free advisory service available to both users and potential users of chemical and biological databases in the United Kingdom and Ireland. Three specific areas are discussed in which queries about Chemical Abstracts Service (CAS) Registry Numbers have been received: isomers, replacing registry numbers, and mixed compounds. (JD)

  9. Citizen Advisory Committees.

    ERIC Educational Resources Information Center

    Miller, Leann R.

    This guide, describing community involvement through citizen advisory committees, is a summary of the literature on such committees. Its main concern is district committees created by school boards. Citations in the bibliography contain all points of view on committees and present many alternatives on most of the topics covered in the guide.…

  10. The UKCIS Advisory Service.

    ERIC Educational Resources Information Center

    Bingham, Archie

    1979-01-01

    Describes the free advisory service available to both users and potential users of chemical and biological databases in the United Kingdom and Ireland. Three specific areas are discussed in which queries about Chemical Abstracts Service (CAS) Registry Numbers have been received: isomers, replacing registry numbers, and mixed compounds. (JD)

  11. 77 FR 25479 - Notification of a Public Meeting of the Science Advisory Board (SAB); Exposure and Human Health...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-30

    ... integrates advances in molecular biology, chemistry and innovative computer science to more effectively and... AGENCY Notification of a Public Meeting of the Science Advisory Board (SAB); Exposure and Human Health Committee AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The EPA Science Advisory...

  12. Methadone maintenance.

    PubMed

    Russell-Taylor, W J

    1975-07-01

    Management of heroin addiction with oral methadone continues to create controversy. Since the first Dole-Nyswander experiments were reported almost a decade ago, methadone maintenance programs have been started in every major city in North America at an estimated public cost in the hundreds of millions of tax dollars. By the end of 1972, the United States alone spending at an annual rate in excess of $250 million, and an expenditure rate in excess of one billion dollars was occurring by the end of 1973. Despite the FDA investigational New Drug status of methadone when used for this purpose, objective data have still not been generated to substantiate the worth of Narcotic Substitution Therapy. Iatrogenic consequences are on the increase, and scepticism is growing among most pharmacologists. A critical evaluation of the entire methadone maintenance approach is being advocated by many and being attempted by some. Data currently being generated at the Philadelphia General Hospital suggest that many patients may have been better managed without methadone.

  13. 75 FR 28542 - Superior Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... orient the new Superior Resource Advisory Committee members on their roles and responsibilities. DATES... of the roles and responsibilities of the Superior Resource Advisory Committee members; Election of...

  14. National and Governmental Advisory Committees: Meetings

    EPA Pesticide Factsheets

    Meetings and Teleconference Information for the National Advisory Committee and Governmental Advisory Committee to the United States Representative to the North American Commission for Environmental Cooperation,

  15. 75 FR 26918 - Siuslaw Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Siuslaw Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Siuslaw Resource Advisory Committee will meet in Corvallis,...

  16. 75 FR 39910 - Dixie Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Dixie Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meetings. SUMMARY: The Dixie Resource Advisory Committee will meet in Cedar City,...

  17. 78 FR 22842 - Nicolet Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Nicolet Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Nicolet Resource Advisory Committee will meet in Crandon, WI....

  18. 76 FR 45504 - Virginia Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Virginia Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Virginia Resource Advisory Committee will meet in Roanoke...

  19. Metabolic response evaluated by 18F-FDG PET/CT as a potential screening tool in identifying a subgroup of patients with advanced non-small cell lung cancer for immediate maintenance therapy after first-line chemotherapy.

    PubMed

    Moon, Seung Hwan; Cho, Su-Hee; Park, Lee Chun; Ji, Jun Ho; Sun, Jong-Mu; Ahn, Jin Sock; Park, Keunchil; Choi, Joon Young; Ahn, Myung-Ju

    2013-07-01

    Among patients with advanced non-small cell lung cancer (NSCLC), identification of a subgroup of patients for immediate maintenance treatment after first-line chemotherapy has great importance in improving survival. The purpose of this study was to investigate whether the metabolic responses evaluated by (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) may be a potential screening tool for identifying patients with early disease progression who may benefit from immediate maintenance treatment. A total of 52 patients with advanced NSCLC (36 men and 16 women, mean age 57.2 ± 10.6 years) who underwent baseline and follow-up (18)F-FDG PET/CT after four cycles of first-line chemotherapy were enrolled. Maximum standardized uptake value (SUV(max)), SUV(peak), metabolic tumour volume (MTV) and total lesion glycolysis (TLG) of the tumour lesions were measured and percentage decrease of the parameters was calculated. The prognostic significance of percentage decrease of these parameters and other clinical variables related to progression-free survival (PFS) and overall survival (OS) were assessed by Cox proportional hazards regression analysis. Receiver-operating characteristic (ROC) curve analysis was used to define the optimal cut-off value of percentage decrease of the parameters that could distinguish between early (PFS < 6 months) and late (PFS ≥ 6 months) disease progression groups. Multivariate analysis showed that percentage decrease of TLG [hazard ratio per 10% decrease = 1.030, 95% confidence interval (CI) = 1.012-1.048, p = 0.001) was a significant predictor of PFS and OS. ROC curves identified a 50.0% decrease in TLG as the optimal cut-off value to distinguish disease progression groups. Positive and negative predictive values of the optimal TLG value for selecting patients with late disease progression were 36.4 and 100.0%, respectively. The percentage decrease in TLG of measurable tumour lesions may be a potential parameter to appropriately

  20. The Food and Drug Administration advisory committees and panels: how they are applied to the drug regulatory process.

    PubMed

    Ciociola, Arthur A; Karlstadt, Robyn G; Pambianco, Daniel J; Woods, Karen L; Ehrenpreis, Eli D

    2014-10-01

    Food and Drug Administration (FDA) advisory panels and committees play a critical role in advising the FDA on the safety and efficacy of medical devices and drugs marketed in the US. Advisory panel recommendations are used by the FDA to make decisions regarding medical products. Currently, the FDA utilizes over 50 advisory panels that serve the three major FDA centers, including the Centers for Biologics, Drugs and Device Products. Members of an advisory panel typically include academicians, clinicians, consumers, patients, and industry representatives. The FDA establishes the schedules for advisory panel meetings on an annual basis and a panel usually meets several times a year for two consecutive days in Washington, DC. Typically, the advisory panel discusses issues highlighted by the FDA and is then asked to vote a response to the questions posed in advance by the FDA. Advisory panel recommendations have a strong influence on FDA's decision to approve a product, as evidenced by the 214 Advisory Panels FDA convened between January 2008 to November 2012, during which advisory panel members voted to approve the product (or use of the product) ∼74% of the time, with FDA ultimately approving the medical product (or use of the product) ∼79% of the time. The ACG membership are encouraged to consider serving the public's interest by participating in an FDA advisory panel utilizing their expertise for the evaluation of a new drug or medical device, and providing advice about whether the product should be sold in the US.

  1. Numerical Data Advisory Board assembly of mathematial and physical sciences

    SciTech Connect

    Not Available

    1980-07-30

    The Numerical Data Advisory Board (NDAB) is an advisory body that provides expert overview, on a broad basis, of data needs and data programs as required for the advancement of science and technology. Board members, representing various disciplines, concern themselves with the quality, reliability, availability, accessibility, and dissemination of numerical data in physical, chemical, engineering, and interdisciplinary subjects as well as numeric and non-numeric data that arise in biology and geology. Topics of concern are addressed by the NDAB membership, or by specific, carefully chosen committees and panels established by NDAB in order to include experts appropriate to the subject at hand.

  2. Life and Biomedical Sciences and Applications Advisory Subcommittee Meeting

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The proceedings of the August 1995 meeting of the Life and Biomedical Sciences and Applications Advisory Subcommittee (LBSAAS) are summarized. The following topics were addressed by the Subcommittee members: the activities and status of the LBSA Division; program activities of the Office of Life and Microgravity Sciences and Applications (OLMSA); the medical Countermeasures Program; and the Fettman Report on animal research activities at ARC. Also presented were a history and overview of the activities of the Space Station Utilization Advisory Committee and the Advanced Life Support Program (ALSP). The meeting agenda and a list of the Subcommittee members and meeting attendees are included as appendices.

  3. Life and Biomedical Sciences and Applications Advisory Subcommittee Meeting

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The proceedings of the August 1995 meeting of the Life and Biomedical Sciences and Applications Advisory Subcommittee (LBSAAS) are summarized. The following topics were addressed by the Subcommittee members: the activities and status of the LBSA Division; program activities of the Office of Life and Microgravity Sciences and Applications (OLMSA); the medical Countermeasures Program; and the Fettman Report on animal research activities at ARC. Also presented were a history and overview of the activities of the Space Station Utilization Advisory Committee and the Advanced Life Support Program (ALSP). The meeting agenda and a list of the Subcommittee members and meeting attendees are included as appendices.

  4. Drive alignment pays maintenance dividends

    SciTech Connect

    Fedder, R.

    2008-12-15

    Proper alignment of the motor and gear drive on conveying and processing equipment will result in longer bearing and coupling life, along with lower maintenance costs. Selecting an alignment free drive package instead of a traditional foot mounted drive and motor is a major advancement toward these goals. 4 photos.

  5. Role of Gemcitabine and Pemetrexed as Maintenance Therapy in Advanced NSCLC: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

    PubMed Central

    Feng, Xuqin; Wen, Shimin; Fu, Xi; Guo, Cuihua; He, Wenwu

    2016-01-01

    Background Gemcitabine and pemetrexed have been used as maintenance therapy. However, few systematic reviews and meta-analyses have assessed their effects in the newest studies. This systematic review and meta-analysis were conducted to assess the role of gemcitabine and pemetrexed in the maintenance treatment of non-small-cell lung carcinoma (NSCLC). Methods We performed a literature search using PubMed, EMBASE and Cochrane library databases from their inceptions to September 16, 2015. We also searched the American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), and National Comprehensive Cancer Network (NCCN) databases from 2008 to 2015. Two authors independently extracted the data. The Cochrane Collaboration’s risk of bias graph was used to assess the risk of bias. The GRADE system was used to assess the grading of evidence, and a meta-analysis was conducted using Stata 11.0 software. Results Eleven randomized controlled trial (RCT) studies were collected. Ten studies were included in the meta-analysis and divided into the following 4 groups: gemcitabine vs. best supportive care (BSC)/observation, pemetrexed vs. BSC/placebo, pemetrexed + bevacizumab vs. bevacizumab and pemetrexed vs. bevacizumab. Gemcitabine exhibited significantly improved progression-free survival (PFS) compared with BSC (hazard ratio (HR) = 0.62, p = 0.000). Pemetrexed exhibited significantly improved PFS (HR = 0.54, p = 0.000) and OS (HR = 0.75, p = 0.000) compared with BSC. Pemetrexed + bevacizumab almost exhibited significantly improved PFS (HR = 0.71, p = 0.051) compared with bevacizumab. Pemetrexed exhibited no improvement in PFS or overall survival (OS) compared with bevacizumab. Regarding the grade, the GRADE system indicated that the gemcitabine group was "MODERATE", the pemetrexed group was "HIGH", and both the pemetrexed + bevacizumab vs. bevacizumab groups and pemetrexed vs. B groups were "LOW". Conclusions Gemcitabine or pemetrexed compared

  6. 78 FR 51191 - Government-wide Travel Advisory Committee (GTAC); Public Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... ADMINISTRATION Government-wide Travel Advisory Committee (GTAC); Public Advisory Committee Meeting AGENCY: Office... Government-wide Travel Advisory Committee (GTAC) (the Committee), is a Federal Advisory Committee established in accordance with the Federal Advisory Committee Act (FACA), 5 U.S.C., App 2. This ] notice...

  7. 78 FR 56231 - Government-Wide Travel Advisory Committee (GTAC); Public Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... ADMINISTRATION Government-Wide Travel Advisory Committee (GTAC); Public Advisory Committee Meeting AGENCY: Office... Government-wide Travel Advisory Committee (GTAC) (the Committee), is a Federal Advisory Committee established... CONTACT: Ms. Marcerto Barr, Designated Federal Officer (DFO), Government-wide Travel Advisory Committee...

  8. 77 FR 47706 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... AFFAIRS Advisory Committee on Disability Compensation; Notice of Meeting The Department of Veterans... Committee on Disability Compensation will meet on August 21-22, 2012, at the St. Regis Hotel, 923 16th and K... the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities. The Committee is...

  9. 77 FR 70549 - Advisory Committee on Disability Compensation, Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... AFFAIRS Advisory Committee on Disability Compensation, Notice of Meeting The Department of Veterans... Committee on Disability Compensation will meet on December 5-6, 2012, at the Hilton Homewood Suites, 1475... Affairs on the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities. The...

  10. 77 FR 77186 - Advisory Committee on Disability Compensation; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-31

    ... AFFAIRS Advisory Committee on Disability Compensation; Notice of Meeting The Department of Veterans... Committee on Disability Compensation will meet on January 28-29, 2013, at the Veterans Health Administration... maintenance and periodic readjustment of the VA Schedule for Rating Disabilities. The Committee is to assemble...

  11. 78 FR 54516 - Advisory Committee on Disability Compensation, Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-04

    ... AFFAIRS Advisory Committee on Disability Compensation, Notice of Meeting The Department of Veterans... Committee on Disability Compensation will meet on September 10-11, 2013, at the Department of Veterans... Affairs on the maintenance and periodic readjustment of the VA Schedule for Rating Disabilities....

  12. 75 FR 43156 - Federal Advisory Committee; Missile Defense Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-23

    ... staff and Program Managers on the Agency's strategic perspective and the Ballistic Missile Defense..., but are not limited to briefings on the Ballistic Missile Defense Review, Early Intercept, Phased... Office of the Secretary Federal Advisory Committee; Missile Defense Advisory Committee AGENCY:...

  13. Ash cloud aviation advisories

    SciTech Connect

    Sullivan, T.J.; Ellis, J.S.; Schalk, W.W.; Nasstrom, J.S.

    1992-06-25

    During the recent (12--22 June 1991) Mount Pinatubo volcano eruptions, the US Air Force Global Weather Central (AFGWC) requested assistance of the US Department of Energy`s Atmospheric Release Advisory Capability (ARAC) in creating volcanic ash cloud aviation advisories for the region of the Philippine Islands. Through application of its three-dimensional material transport and diffusion models using AFGWC meteorological analysis and forecast wind fields ARAC developed extensive analysis and 12-hourly forecast ash cloud position advisories extending to 48 hours for a period of five days. The advisories consisted of ``relative`` ash cloud concentrations in ten layers (surface-5,000 feet, 5,000--10,000 feet and every 10,000 feet to 90,000 feet). The ash was represented as a log-normal size distribution of 10--200 {mu}m diameter solid particles. Size-dependent ``ashfall`` was simulated over time as the eruption clouds dispersed. Except for an internal experimental attempt to model one of the Mount Redoubt, Alaska, eruptions (12/89), ARAC had no prior experience in modeling volcanic eruption ash hazards. For the cataclysmic eruption of 15--16 June, the complex three-dimensional atmospheric structure of the region produced dramatically divergent ash cloud patterns. The large eruptions (> 7--10 km) produced ash plume clouds with strong westward transport over the South China Sea, Southeast Asia, India and beyond. The low-level eruptions (< 7 km) and quasi-steady-state venting produced a plume which generally dispersed to the north and east throughout the support period. Modeling the sequence of eruptions presented a unique challenge. Although the initial approach proved viable, further refinement is necessary and possible. A distinct need exists to quantify eruptions consistently such that ``relative`` ash concentrations relate to specific aviation hazard categories.

  14. Aerospace safety advisory panel

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This report from the Aerospace Safety Advisory Panel (ASAP) contains findings, recommendations, and supporting material concerning safety issues with the space station program, the space shuttle program, aeronautics research, and other NASA programs. Section two presents findings and recommendations, section three presents supporting information, and appendices contain data about the panel membership, the NASA response to the March 1993 ASAP report, and a chronology of the panel's activities during the past year.

  15. 16 CFR 1018.26 - Advisory functions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Advisory functions. 1018.26 Section 1018.26 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 1018.26 Advisory functions. (a) Unless otherwise specifically provided by statute...

  16. 16 CFR 1018.26 - Advisory functions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Advisory functions. 1018.26 Section 1018.26 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 1018.26 Advisory functions. (a) Unless otherwise specifically provided by statute...

  17. 78 FR 77443 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-23

    ... Electricity Advisory Committee AGENCY: Office of Electricity Delivery and Energy Reliability, Department of... Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat. 770.../oe/services/electricity-advisory-committee-eac . FOR FURTHER INFORMATION CONTACT: Matthew...

  18. 75 FR 56997 - Global Markets Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... COMMISSION Global Markets Advisory Committee AGENCY: Commodity Futures Trading Commission (``CFTC''). ACTION: Notice of meeting of Global Markets Advisory Committee. SUMMARY: The Global Markets Advisory Committee...., Washington, DC 20581, attention Office of the Secretary. Please use the title ``Global Markets Advisory...

  19. 76 FR 25309 - Agricultural Advisory Committee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... COMMISSION Agricultural Advisory Committee; Meeting AGENCY: Commodity Futures Trading Commission (``CFTC''). ] ACTION: Notice of Meeting of Agricultural Advisory Committee. SUMMARY: The CFTC's Agricultural Advisory..., DC 20581. Written statements should be sent to the attention of Agricultural Advisory Committee, c/o...

  20. 76 FR 58813 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-22

    ... SECURITY Homeland Security Advisory Council AGENCY: The Office of Policy, DHS. ACTION: Notice of open teleconference Federal Advisory Committee meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will... message. Fax: (202) 282-9207 Mail: Homeland Security Advisory Council, Department of Homeland Security...

  1. 77 FR 64532 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-22

    ... SECURITY Homeland Security Advisory Council AGENCY: The Office of Policy, DHS. ACTION: Notice of open teleconference Federal advisory committee meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will... in the subject line of the message. Fax: (202) 282-9207 Mail: Homeland Security Advisory Council...

  2. 75 FR 2880 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... SECURITY Homeland Security Advisory Council AGENCY: The Office of Policy, DHS. ACTION: Committee management; Notice of partially closed federal advisory committee meeting. SUMMARY: The Homeland Security Advisory.... E-mail: HSAC@dhs.gov . Fax: 202-282-9207. Mail: Homeland Security Advisory Council, 1100 Hampton...

  3. 76 FR 55079 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... SECURITY Homeland Security Advisory Council AGENCY: The Office of Policy, DHS. ACTION: Notice of Open Teleconference Federal Advisory Committee Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will... subject line of the message. Fax: (202) 282-9207. Mail: Homeland Security Advisory Council, Department of...

  4. 16 CFR 1018.26 - Advisory functions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Advisory functions. 1018.26 Section 1018.26 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION GENERAL ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 1018.26 Advisory functions. (a) Unless otherwise specifically provided by...

  5. 75 FR 59278 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... SECURITY Homeland Security Advisory Council AGENCY: The Office of Policy, DHS. ACTION: Notice of Closed Federal Advisory Committee Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet on... message. Fax: (202) 282-9207. Mail: Homeland Security Advisory Council, Department of Homeland Security...

  6. 62 FR 67918 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-12-30

    ... and Evolution of the Universe Advisory Subcommittee; Meeting AGENCY: National Aeronautics and Space... meeting of the NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of the...

  7. 62 FR 45880 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-08-29

    ... and Evolution of the Universe Advisory Subcommittee; Meeting AGENCY: National Aeronautics and Space... of the NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of the...

  8. 64 FR 4721 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1999-01-29

    ... and Evolution of the Universe Advisory Subcommittee; Meeting. AGENCY: National Aeronautics and Space... of the NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of the...

  9. 64 FR 29702 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1999-06-02

    ... and Evolution of the Universe Advisory Subcommittee; Meeting AGENCY: National Aeronautics and Space... of the NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of the...

  10. 63 FR 52771 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1998-10-01

    ... and Evolution of the Universe Advisory Subcommittee; Meeting AGENCY: National Aeronautics and Space... of the NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of the...

  11. 61 FR 40662 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-08-05

    ... and Evolution of the Universe Advisory Subcommittee; Meeting AGENCY: National Aeronautics and Space... of the NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of the...

  12. 78 FR 17210 - Meeting Notice for the President's Advisory Council on Faith-Based and Neighborhood Partnerships

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ...: Please contact Ben O'Dell for any additional information about the President's Advisory Council meeting... sent in advance to partnerships@hhs.gov . Dated: March 14, 2013. Ben O'Dell, Associate Director...

  13. Impacts of traditional food consumption advisories: compliance, changes in diet and loss of confidence in traditional foods.

    PubMed

    McAuley, Claire; Knopper, Loren D

    2011-06-08

    Food consumption advisories are often posted when industrial activities are expected to affect the quality and availability of traditional foods used by First Nations. We were recently involved in a project and asked to summarize details regarding the impacts of traditional food consumption advisories with respect to compliance, broader changes in diet and loss of confidence in traditional foods by people. Our review was not conducted as a formal systematic comprehensive review; rather, we focused on primary and grey literature presenting academic, health practitioner and First Nations viewpoints on the topic available from literature databases (i.e., PubMed, Web of Knowledge (SM)) as well as the internet search engine Google. Some information came from personal communications. Our overview suggests that when communicated effectively and clearly, and when community members are involved in the process, consumption advisories can result in a decrease in contaminant load in people. On the other hand, consumption advisories can lead to cultural loss and have been linked to a certain amount of social, psychological, nutritional, economic and lifestyle disruption. In some cases, communities have decided to ignore consumption advisories opting to continue with traditional lifestyles believing that the benefits of doing so outweigh the risk of following advisories. We identified that there are both positive and negative aspects to the issuance of traditional food consumption advisories. A number of variables need to be recognized during the development and implementation of advisories in order to ensure a balance between human health, maintenance of cultures and industrial activity.

  14. Federal Advisory Committees: An Overview

    DTIC Science & Technology

    2009-04-16

    initiating a tradition of presidential use of outside expertise when, in 1794 , he appointed an ad hoc group of commissioners to investigate the Whiskey ... Rebellion .7 Since 1842, Congress has legislated control over federal advisory bodies — mostly by limiting funding and committee member pay. In 1842...reports aggregated advisory body information to Congress annually.12 7 " Whiskey Insurrection in

  15. Federal Advisory Committees: A Primer

    DTIC Science & Technology

    2007-03-20

    20 The Denali Commission . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 President’s Council...the Lakes Advisory Board;10 Trade Deficit Review Commission;11 Denali Commission;12 President’s Council on Counter-Narcotics;13 Parents’ Advisory...statutory authority of the seven-member Denali Commission26 authorizes the Governor of Alaska, or an individual selected by the governor, to serve as the

  16. OCLC and Its Advisory Committees.

    ERIC Educational Resources Information Center

    Baker, Shirley K.

    1998-01-01

    Describes the Online Computer Library Center (OCLC) advisory committees in terms of research, public, college and university, and special libraries. All four of the type-of-library advisory groups work to shape OCLC policies and programs, according to the particular needs of each group. OCLC's financial and programmatic success depends upon…

  17. 75 FR 4069 - Science Advisory Board Staff Office; Notification of a Clean Air Scientific Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-26

    ... Clean Air Scientific Advisory Committee (CASAC) Ambient Air Monitoring & Methods Subcommittee (AAMMS or... AGENCY Science Advisory Board Staff Office; Notification of a Clean Air Scientific Advisory Committee (CASAC); Ambient Air Methods and Monitoring Subcommittee (AAMMS); Meeting and Public Teleconference...

  18. 75 FR 60458 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital Age...

  19. 75 FR 70004 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-16

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital Age...

  20. 75 FR 20844 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital Age...

  1. 75 FR 6031 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital Age...

  2. 78 FR 30305 - The President's Management Advisory Board (PMAB); Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... ADMINISTRATION The President's Management Advisory Board (PMAB); Public Advisory Meeting AGENCY: Office of Executive Councils, U.S. General Services Administration (GSA). ACTION: Notice. SUMMARY: The President's..., Designated Federal Officer, President's Management Advisory Board, Office of Executive Councils, General...

  3. 77 FR 57085 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital Age (``Diversity Committee''). The Committee's mission is to provide recommendations to the Commission...

  4. 76 FR 64348 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-18

    ... COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital Age (``Diversity Committee''). The Committee's mission is to provide recommendations to the Commission...

  5. 78 FR 21354 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital... Communications Commission's (FCC) Advisory Committee on Diversity for Communications in the Digital Age (``Diversity Committee''). The Committee's mission is to provide recommendations to the Commission...

  6. 77 FR 6113 - Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-07

    ... COMMISSION Federal Advisory Committee Act; Advisory Committee on Diversity for Communications in the Digital... Communications Commission's (FCC's) Advisory Committee on Diversity for Communications in the Digital Age (``Diversity Committee''). The Committee's mission is to provide recommendations to the Commission...

  7. 77 FR 55863 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... SPACE ADMINISTRATION NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory Group Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of... Aeronautics and Space Administration (NASA) announces a meeting of the Applied Science Advisory Group. This...

  8. 77 FR 70482 - Notice of Establishment of a NASA Federal Advisory Committee; Applied Sciences Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... SPACE ADMINISTRATION Notice of Establishment of a NASA Federal Advisory Committee; Applied Sciences... the establishment of the Applied Sciences Advisory Committee as a Federal advisory committee under... Integration and Management Division, Science Mission Directorate, NASA Headquarters, 300 E Street...

  9. 76 FR 70425 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... Office of the Secretary Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board... discussions of classified information relating to DIA's intelligence operations including its support to... Advisory Board to discuss DIA operations and capabilities in support of current intelligence operations...

  10. 77 FR 2277 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-17

    ... of the Secretary Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed... discussions of classified information relating to DIA's intelligence operations including its support to... Advisory Board to discuss DIA operations and capabilities in support of current intelligence operations...

  11. Maintenance Business Plans.

    ERIC Educational Resources Information Center

    Adams, Matt

    2002-01-01

    Discusses maintenance business plans, statements which provide accountability for facilities maintenance organizations' considerable budgets. Discusses the plan's components: statement of plan objectives, macro and detailed description of the facility assets, maintenance function descriptions, description of key performance indicators, milestone…

  12. Maintenance Management Update.

    ERIC Educational Resources Information Center

    Sternloff, Robert E.

    1987-01-01

    Current trends in park maintenance are overviewed, including maintenance impact statements, avoidance of cost through efficient use and national resource conservation, horticultural accomplishments that influence maintenance management, and vandalism prevention. (CB)

  13. Maintenance Management Update.

    ERIC Educational Resources Information Center

    Sternloff, Robert E.

    1987-01-01

    Current trends in park maintenance are overviewed, including maintenance impact statements, avoidance of cost through efficient use and national resource conservation, horticultural accomplishments that influence maintenance management, and vandalism prevention. (CB)

  14. Myths and realities of electronics maintenance.

    PubMed

    Harris, Douglas H

    2008-06-01

    The author presents and discusses discoveries and developments contributing to enhanced electronics maintenance performance. This body of research is viewed from the vantage point of Nick Bond's 1970 Ely Award-winning article in Human Factors, "Some Persistent Myths About Military Electronics Maintenance." Bond identified a set of myths and summarized research that not only produced information and techniques leading to demonstrably improved maintenance performance but also exploded many unfounded beliefs that were commonly held before the research had been conducted and the findings disseminated. The period from 1964 through 1986, as reflected by publications in the journal, was a productive period of research that led to greater understanding of human factors in electronics maintenance and to numerous advances that contributed, ultimately, to more effective maintenance performance. Technological advances, combined with what we learned about maintenance performance, have substantially reduced the maintenance burden and enhanced the maintenance of electronic systems. Some of the principal lessons learned from this research on electronics maintenance apply to understanding the effects of equipment complexity, providing an optimal role for automation, designing more appropriate on-the-job training, and enhancing troubleshooting skills.

  15. 76 FR 7551 - Advisory Committee on Student Financial Assistance: Hearing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ... Advisory Committee on Student Financial Assistance: Hearing AGENCY: Advisory Committee on Student Financial... Student Financial Assistance (the Advisory Committee). This notice also describes the functions of the.... Alison Bane, Associate Director of Government Relations, Advisory Committee on Student...

  16. Biomarker analyses from a randomized, placebo-controlled, phase IIIb trial comparing bevacizumab with or without erlotinib as maintenance therapy for the treatment of advanced non-small-cell lung cancer (ATLAS).

    PubMed

    Kabbinavar, Fairooz; Fehrenbacher, Louis; Hainsworth, John; Kasubhai, Saifuddin; Kressel, Bruce; Marsland, Thomas; Patel, Taral; Rubin, Mark; White, Leonard; Yang, James Chih-Hsin; Klughammer, Barbara; Colburn, Dawn; Miller, Vincent; Johnson, Bruce E

    2014-09-01

    ATLAS compared bevacizumab plus erlotinib (B+E) with bevacizumab plus placebo (B+P) as maintenance therapy after first-line bevacizumab plus chemotherapy (B+C) for advanced non-small-cell lung cancer (NSCLC). Prespecified biomarkers were prospectively evaluated. Tumor samples were analyzed for: epidermal growth factor receptor (EGFR) expression (immunohistochemistry [IHC]); EGFR gene copy number (fluorescence in-situ hybridization [FISH]); EGFR mutations (exon 19 deletions/L858R mutations); and KRAS mutations (exons 2/3). Progression-free survival (PFS) and overall survival (OS) were estimated. Of 743 patients randomized to receive maintenance treatment (after four cycles of B+C without progression), 190 (B+E) and 177 (B+P) were evaluable for biomarker status. Median PFS (from randomization) was 4.4 months (B+E) versus 3.7 months (B+P; hazard ratio [HR], 0.75; 95% confidence interval [CI], 0.57-0.99), which was numerically similar to the intent-to-treat PFS. PFS benefit of B+E was observed across most biomarker subgroups. EGFR IHC, EGFR FISH, and EGFR/KRAS mutation status were not predictive of outcome. B+E-treated patients with EGFR mutation-positive NSCLC had longer PFS compared with B+P-treated patients (HR, 0.44; 95% CI, 0.22-0.86; p = 0.0139). Patients with KRAS wild-type disease had significant PFS improvements with B+E, compared with B+P (HR, 0.66; 95% CI, 0.485-0.914; p = 0.0105). No OS benefit of B+E was observed. Patients with KRAS wild-type or EGFR mutation-positive NSCLC derived PFS benefits from B+E. However, EGFR IHC, EGFR FISH, and EGFR or KRAS mutation status were not strongly predictive of survival. A larger sample size would be needed to confirm the initial trends observed in this study.

  17. 40 CFR 86.429-78 - Maintenance, unscheduled; test vehicles.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 18 2011-07-01 2011-07-01 false Maintenance, unscheduled; test... Emission Regulations for 1978 and Later New Motorcycles, General Provisions § 86.429-78 Maintenance... advance approval of the Administrator. (1) In the case of unscheduled maintenance, such approval will...

  18. 76 FR 21349 - Science Advisory Board Staff Office; Request for Nominations of Candidates to the EPA's Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-15

    ... AGENCY Science Advisory Board Staff Office; Request for Nominations of Candidates to the EPA's Advisory Council on Clean Air Compliance Analysis (Council) EPA's Clean Air Scientific Advisory Committee (CASAC) and EPA's Science Advisory Board (SAB) AGENCY: Environmental Protection Agency. ACTION:...

  19. Associations between chlorophyll a and various microcystin health advisory concentrations

    PubMed Central

    Hollister, Jeffrey W.; Kreakie, Betty J.

    2016-01-01

    Cyanobacteria harmful algal blooms (cHABs) are associated with a wide range of adverse health effects that stem mostly from the presence of cyanotoxins. To help protect against these impacts, several health advisory levels have been set for some toxins. In particular, one of the more common toxins, microcystin, has several advisory levels set for drinking water and recreational use. However, compared to other water quality measures, field measurements of microcystin are not commonly available due to cost and advanced understanding required to interpret results. Addressing these issues will take time and resources. Thus, there is utility in finding indicators of microcystin that are already widely available, can be estimated quickly and in situ, and used as a first defense against high levels of microcystin. Chlorophyll a is commonly measured, can be estimated in situ, and has been shown to be positively associated with microcystin. In this paper, we use this association to provide estimates of chlorophyll a concentrations that are indicative of a higher probability of exceeding select health advisory concentrations for microcystin. Using the 2007 National Lakes Assessment and a conditional probability approach, we identify chlorophyll a concentrations that are more likely than not to be associated with an exceedance of a microcystin health advisory level. We look at the recent US EPA health advisories for drinking water as well as the World Health Organization levels for drinking water and recreational use and identify a range of chlorophyll a thresholds. A 50% chance of exceeding one of the specific advisory microcystin concentrations of 0.3, 1, 1.6, and 2 μg/L is associated with chlorophyll a concentration thresholds of 23, 68, 84, and 104 μg/L, respectively. When managing for these various microcystin levels, exceeding these reported chlorophyll a concentrations should be a trigger for further testing and possible management action. PMID:27127617

  20. Associations between chlorophyll a and various microcystin health advisory concentrations.

    PubMed

    Hollister, Jeffrey W; Kreakie, Betty J

    2016-01-01

    Cyanobacteria harmful algal blooms (cHABs) are associated with a wide range of adverse health effects that stem mostly from the presence of cyanotoxins. To help protect against these impacts, several health advisory levels have been set for some toxins. In particular, one of the more common toxins, microcystin, has several advisory levels set for drinking water and recreational use. However, compared to other water quality measures, field measurements of microcystin are not commonly available due to cost and advanced understanding required to interpret results. Addressing these issues will take time and resources. Thus, there is utility in finding indicators of microcystin that are already widely available, can be estimated quickly and in situ, and used as a first defense against high levels of microcystin. Chlorophyll a is commonly measured, can be estimated in situ, and has been shown to be positively associated with microcystin. In this paper, we use this association to provide estimates of chlorophyll a concentrations that are indicative of a higher probability of exceeding select health advisory concentrations for microcystin. Using the 2007 National Lakes Assessment and a conditional probability approach, we identify chlorophyll a concentrations that are more likely than not to be associated with an exceedance of a microcystin health advisory level. We look at the recent US EPA health advisories for drinking water as well as the World Health Organization levels for drinking water and recreational use and identify a range of chlorophyll a thresholds. A 50% chance of exceeding one of the specific advisory microcystin concentrations of 0.3, 1, 1.6, and 2 μg/L is associated with chlorophyll a concentration thresholds of 23, 68, 84, and 104 μg/L, respectively. When managing for these various microcystin levels, exceeding these reported chlorophyll a concentrations should be a trigger for further testing and possible management action.

  1. First-line pemetrexed plus cisplatin followed by gefitinib maintenance therapy versus gefitinib monotherapy in East Asian patients with locally advanced or metastatic non-squamous non-small cell lung cancer: a randomised, phase 3 trial.

    PubMed

    Yang, James Chih-Hsin; Kang, Jin Hyoung; Mok, Tony; Ahn, Myung-Ju; Srimuninnimit, Vichien; Lin, Chia-Chi; Kim, Dong-Wan; Tsai, Chun-Ming; Barraclough, Helen; Altug, Sedat; Orlando, Mauro; Park, Keunchil

    2014-09-01

    In the Iressa Pan-ASia Study (IPASS), gefitinib claimed improved progression-free survival (PFS) versus carboplatin-paclitaxel in clinically selected lung cancer patients. The primary objective of this study was to assess the PFS of pemetrexed-cisplatin (PC) followed by gefitinib maintenance versus gefitinib monotherapy in an IPASS-like population. In this open-label, randomised, phase 3 trial, eligible patients were ⩾18 years, chemonaïve, East Asian, light ex-smokers/never-smokers with advanced non-squamous non-small cell lung cancer, an Eastern Cooperative Oncology Group (ECOG) performance status 0-1 and unknown epidermal growth factor receptor (EGFR) mutation status who enrolled at 12 sites in Asia. Patients randomly received (1:1) pemetrexed (500 mg/m(2)) plus cisplatin (75mg/m(2)) for six 21-day cycles, followed by gefitinib maintenance or gefitinib monotherapy (250 mg/day). Patient tissue was retrospectively analysed for EGFR mutations. This study is registered with ClinicalTrials.gov, NCT01017874. Between 23rd November 2009 and 27th April 2012, 253 patients entered, and 236 patients were randomly assigned to and treated with PC therapy (N=114) and gefitinib monotherapy (N=118). Between-arm baseline characteristics were balanced. PFS was not significantly different between treatment arms (p=0.217). The unadjusted hazard ratio (HR) was 0.85 (95% confidence interval (CI) 0.63-1.13). The HR should be cautiously interpreted as it was not constant. EGFR mutation status was determined for 74 tissue samples; 50 (67.6%) had mutations. In a pre-specified subgroup analysis, only the treatment-by-EGFR mutation interaction was significant (p=0.008) for PFS. For the entire treatment period, a higher proportion of patients in the PC/gefitinib arm versus gefitinib experienced possibly drug-related grade 3-4 treatment-emergent adverse events (39 of 114 [34%] versus 19 of 118 [16%]; p=0.002). In the intention-to-treat (ITT) population, PFS was not significantly different

  2. 76 FR 71033 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-16

    ..., DC 20554. FOR FURTHER INFORMATION CONTACT: Walter Johnston, Chief, Electromagnetic Compatibility Division, (202) 418-0807; Walter.Johnston@FCC.gov . SUPPLEMENTARY INFORMATION: Technical Advisory Council... written comments before the meeting to: Walter Johnston, the FCC's Designated Federal Officer...

  3. Grounds Maintenance Cost Report.

    ERIC Educational Resources Information Center

    Joice, Donald K.

    A grounds maintenance study was accomplished over the period of March 1965 through February 1966 to--(1) determine current grounds maintenance cost distribution; (2) provide basis for future grounds maintenance budgeting, and (3) provide basic data by which future landscape project designs can be developed to project or reduce maintenance costs.…

  4. National Environmental Justice Advisory Council

    EPA Pesticide Factsheets

    The National Environmental Justice Advisory Council (NEJAC) provides advice and recommendations about broad, cross-cutting issues related to environmental justice, from all stakeholders involved in the environmental justice dialogue.

  5. Chemical Safety Advisory Committee (CSAC)

    EPA Pesticide Factsheets

    Chemical Safety Advisory Committee (CSAC) provides expert scientific advice, information, and recommendations to the Office of Pollution Prevention and Toxics (OPPT) on the scientific basis for risk assessments, methodologies, and pollution prevention meas

  6. 78 FR 70960 - Utah Resource Advisory Council/Recreation Resource Advisory Council Meeting/Conference Call

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... Bureau of Land Management Utah Resource Advisory Council/Recreation Resource Advisory Council Meeting..., and the Federal Lands Recreation Enhancement Act, the Bureau of Land Management's (BLM) Utah Resource Advisory Council (RAC)/Recreation Resource Advisory Council (RRAC) will host a meeting/conference call...

  7. 77 FR 69869 - National Advisory Council on Alcohol Abuse and Alcoholism, National Advisory Council on Drug...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... HUMAN SERVICES National Institutes of Health National Advisory Council on Alcohol Abuse and Alcoholism... hereby given of a joint teleconference and Web cast meeting of the National Advisory Council on Alcohol... Alcohol Abuse and Alcoholism, National Advisory Council on Drug Abuse, and National Cancer Advisory Board...

  8. 75 FR 22757 - Federal Advisory Committee; Army Education Advisory Committee; Charter Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... of the Secretary Federal Advisory Committee; Army Education Advisory Committee; Charter Renewal... renewing the charter for the Army Education Advisory Committee (hereafter referred to as the Committee... advisory committee that shall provide the Secretary of Defense, through the Secretary of the Army and...

  9. 68 FR 7148 - NASA Advisory Council, Space Science Advisory Committee Structure and Evolution of the Universe...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2003-02-12

    ... SPACE ADMINISTRATION NASA Advisory Council, Space Science Advisory Committee Structure and Evolution of... Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of the Universe... following topics: --Status of Astronomy and Physics Programs. --Structure and Evolution of the Universe...

  10. 67 FR 68209 - NASA Advisory Council, Space Science Advisory Committee; Structure and Evolution of the Universe...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2002-11-08

    ... From the Federal Register Online via the Government Publishing Office NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NASA Advisory Council, Space Science Advisory Committee; Structure and Evolution of... Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of the Universe...

  11. 67 FR 46699 - NASA Advisory Council, Space Science Advisory Committee Structure and Evolution of the Universe...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2002-07-16

    ... From the Federal Register Online via the Government Publishing Office NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NASA Advisory Council, Space Science Advisory Committee Structure and Evolution of... Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of the Universe...

  12. 75 FR 54871 - Science Advisory Board Staff Office; Notification of a Clean Air Scientific Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... AGENCY Science Advisory Board Staff Office; Notification of a Clean Air Scientific Advisory Committee...). ACTION: Notice. SUMMARY: The Environmental Protection Agency (EPA) Science Advisory Board (SAB) Staff... Officer (DFO), EPA Science Advisory Board (1400R), U.S. Environmental Protection Agency, 1200...

  13. Practice advisory on liposuction.

    PubMed

    Iverson, Ronald E; Lynch, Dennis J

    2004-04-15

    COMMITTEE STATEMENT: At the 69th annual meeting of the American Society of Plastic Surgeons (ASPS) in October of 2000, the ASPS Board of Directors convened the Task Force on Patient Safety in Office-Based Surgery Facilities. The task force was assembled in the wake of several highly publicized patient deaths involving plastic surgery and increasing state legislative and regulatory activity of office-based surgery facilities. In response to the increased scrutiny of the office-based surgery setting, the task force produced two practice advisories: "Procedures in the Office-Based Surgery Setting" and "Patient Selection in the Office-Based Surgery Setting." Since the task force's inception, professional and public awareness of patient safety issues has continued to grow. This heightened interest resulted in an increased need for plastic surgeons to communicate their views on the topic. To meet this challenge, the task force evolved into the Committee on Patient Safety, allowing the committee to address topics affecting the safety and welfare of plastic surgery patients, regardless of the facility setting. The "Practice Advisory on Liposuction" is the first advisory developed since the committee was formed. It was a lengthy and painstaking process for the committee, which included representatives from related plastic surgery organizations as well as the American Society of Anesthesiologists (ASA). Committee members included Ronald E. Iverson, M.D., chair; Jeffery L. Apfelbaum, M.D., ASA representative; Bruce L. Cunningham, M.D., ASPS/Plastic Surgery Educational Foundation (PSEF) Joint Outcomes Task Force representative; Richard A. D'Amico, M.D., ASPS representative; Victor L. Lewis, Jr., M.D., ASPS Health Policy Analysis Committee representative; Dennis J. Lynch, M.D., ASPS representative; Noel B. McDevitt, M.D., ASPS Deep Vein Thrombosis Task Force representative; Michael F. McGuire, M.D., The American Society for Aesthetic Plastic Surgery (ASAPS) representative

  14. Establishing maintenance performance indicators

    SciTech Connect

    Baca, B.

    1994-10-01

    Maintenance Performance Indicators (PI) specify where the maintenance department is and which direction it is going allowing for a quick and accurate assessment of the performance of the Maintenance Management Program (MMP). Establishing PI`s for the maintenance department will allow a measure of productivity and a means of feedback for methods improvement. Effective performance of the maintenance department directly effects plant profitability. Improvements in the quality and productivity of the maintenance work force will significantly reduce maintenance costs. The level of performance attained by the maintenance work force is usually guessed at. Guessing will not identify areas needing improvement or help to initiate a corrective action. Maintenance PI`s are required for maintenance departments whose goal is to control maintenance costs while increasing productivity. The application of basic statistical methods will allow a maintenance department to know where they are and which direction they are going. The data presented in this paper is a representation of indicators used in industry as well as developed indicators to establish a complete maintenance performance indicator program. The methodology used in developing this program can be used as a way to manage a cost effective maintenance management program.

  15. Maintenance management at La Silla Paranal Observatory

    NASA Astrophysics Data System (ADS)

    Montano, Nelson

    2008-07-01

    From the beginning of the VLT project, the European Southern Observatory (ESO) considered the application of a competent maintenance strategy a fundamental aspect for future operations of the Paranal Observatory. For that purpose, a special maintenance philosophy was developed during the project stage and applied during the initial years of operations. The merging of the La Silla and Paranal Observatories in 2005 added a new managerial challenge to the regular operational requirements (high availability and reliability) which motivated ESO Management to develop a stronger strategy for the operations of the new merged Observatory. Part of the new strategy considered the creation of a dedicated department for the management of all maintenance activities, separating this support from the traditional scheme where the Engineering Department had the responsibility for the entire technical support to operations. In order to keep a competent level of maintenance operations for the new unified Observatory, the La Silla Paranal (LSP) Maintenance Department has been using a well known maintenance management model used in various industrial applications as a guide. Today the operations of the Maintenance Department are concentrated on developing and implementing practices regarding concepts such as Maintenance Tactics, Planning, Data Management, Performance Indicators and Material Management. In addition to that, advances related to Reliability Analysis been taken in order to reach a superior level of excellence. The results achieved by the LSP Maintenance Department are reflected in a reduced rate of functional failures, allowing uninterrupted operations of the Observation sites.

  16. 77 FR 70453 - Chemical Transportation Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-26

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HOMELAND SECURITY Coast Guard Chemical Transportation Advisory Committee AGENCY: Coast Guard, DHS. ] ACTION: Committee Management; Notice of Federal Advisory Committee Meeting. SUMMARY: The Chemical...

  17. 5 CFR 724.403 - Advisory guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... RETALIATION ACT OF 2002 Best Practices § 724.403 Advisory guidelines. OPM will issue advisory guidelines to Federal agencies incorporating the best practices identified under § 724.402 that agencies may follow to...

  18. 76 FR 39884 - Aviation Security Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... SECURITY Aviation Security Advisory Committee AGENCY: Transportation Security Administration, DHS. ACTION... Security Administration (TSA) announces the re-establishment of the Aviation Security Advisory Committee... and cost, and have a lower impact on the commerce of aviation. The Aviation Security...

  19. 75 FR 67351 - Environmental Management Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-02

    ... Environmental Management Advisory Board AGENCY: Department of Energy. ACTION: Notice of Open Teleconference. SUMMARY: This notice announces a teleconference of the Environmental Management Advisory Board (EMAB). The... is to provide the Assistant Secretary for Environmental Management (EM) with advice and...

  20. 76 FR 48801 - Gallatin Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Gallatin Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Gallatin National Forest's Gallatin Resource Advisory Committee will meet in Bozeman...

  1. 75 FR 55539 - Shoshone Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Shoshone Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Shoshone Resource Advisory Committee will meet in Thermopolis, Wyoming. The...

  2. 78 FR 41384 - Agricultural Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-10

    ... From the Federal Register Online via the Government Publishing Office COMMODITY FUTURES TRADING COMMISSION Agricultural Advisory Committee Meeting AGENCY: Commodity Futures Trading Commission. ACTION: Notice of Meeting. SUMMARY: The Commodity Futures Trading Commission's (CFTC) Agricultural Advisory...

  3. 76 FR 770 - Mendocino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Mendocino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Mendocino County Resource Advisory Committee will meet January 21, 2011 (RAC)...

  4. 75 FR 26918 - Fishlake Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Fishlake Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Fishlake Resource Advisory Committee will meet in Richfield, Utah. The committee...

  5. 76 FR 4089 - Nicolet Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Nicolet Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of Meeting. SUMMARY: The Nicolet Resource Advisory Committee will meet in Crandon, Wisconsin. The...

  6. 77 FR 49410 - Kisatchie Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Kisatchie Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Kisatchie Resource Advisory Committee will meet in Natchitoches, Louisiana....

  7. 76 FR 22077 - Gogebic Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Gogebic Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Gogebic Resource Advisory Committee will meet in Marenisco, Michigan. The...

  8. 76 FR 2882 - Ontonagon Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Ontonagon Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ontonagon Resource Advisory Committee will meet in Ewen, Michigan. The Committee...

  9. 75 FR 45091 - Ontonagon Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Ontonagon Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ontonagon Resource Advisory Committee will meet in Ontonagon, Michigan....

  10. 78 FR 41362 - Gogebic Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Gogebic Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Gogebic Resource Advisory Committee (RAC) will meet in Watersmeet, Michigan on...

  11. 76 FR 22672 - Nicolet Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Nicolet Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Nicolet Resource Advisory Committee will meet in Crandon, WI. The committee...

  12. 78 FR 22842 - Nicolet Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Nicolet Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Nicolet Resource Advisory Committee will meet in Crandon, WI. The committee...

  13. 76 FR 85 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-03

    ... Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in Flagstaff, Arizona, to finalize...., Flagstaff, Arizona 86004. Send written comments to Brady Smith, RAC Coordinator, Coconino Resource...

  14. 77 FR 50984 - Ontonagon Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Ontonagon Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ontonagon Resource Advisory Committee will meet in Ontonagon, Michigan....

  15. 77 FR 50985 - Gogebic Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Gogebic Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Gogebic Resource Advisory Committee will meet in Watersmeet, Michigan. The...

  16. 77 FR 48126 - Flathead Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Flathead Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meetings. SUMMARY: The Flathead Resource Advisory Committee will meet in Kalispell, Montana. The...

  17. 76 FR 11193 - Superior Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Superior Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Superior Resource Advisory Committee will meet in Duluth, Minnesota. The...

  18. 75 FR 42067 - Chequamegon Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Chequamegon Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Nicolet Resource Advisory Committee will meet in Crandon, Wisconsin. The...

  19. 78 FR 23741 - Flathead Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Flathead Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meetings. SUMMARY: The Flathead Resource Advisory Committee will meet in Kalispell, Montana. The...

  20. 75 FR 3197 - Mendocino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Mendocino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Mendocino County Resource Advisory Committee will meet February 5, 2010 (RAC)...

  1. 76 FR 38109 - Allegheny Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Forest Service Allegheny Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Allegheny Resource Advisory Committee will meet in Marienville, Pennsylvania....

  2. 77 FR 46733 - Marine Fisheries Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ... National Oceanic and Atmospheric Administration RIN 0648-XC145 Marine Fisheries Advisory Committee AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce... of a forthcoming meeting of the Marine Fisheries Advisory Committee (MAFAC). The members will...

  3. 78 FR 3402 - Marine Fisheries Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-16

    ... National Oceanic and Atmospheric Administration RIN 0648-XC443 Marine Fisheries Advisory Committee AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce... of a forthcoming meeting of the Marine Fisheries Advisory Committee (MAFAC). The members will...

  4. 76 FR 14379 - Marine Fisheries Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-16

    ... National Oceanic and Atmospheric Administration RIN 0648-XA265 Marine Fisheries Advisory Committee AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and Atmospheric Administration (NOAA), Commerce... of a forthcoming meeting of the Marine Fisheries Advisory Committee (MAFAC). The members will...

  5. 77 FR 62541 - Investor Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ... From the Federal Register Online via the Government Publishing Office ] SECURITIES AND EXCHANGE COMMISSION Investor Advisory Committee AGENCY: Securities and Exchange Commission. ACTION: Notice of Telephonic Meeting of Securities and Exchange Commission Investor Advisory Committee. SUMMARY: The...

  6. 77 FR 57086 - Open Internet Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... COMMISSION Open Internet Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date, time, and agenda of the Open Internet Advisory... Open Internet rules, and to provide any recommendations it deems appropriate to the...

  7. 78 FR 16852 - Open Internet Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-19

    ... COMMISSION Open Internet Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date, time, and agenda of the Open Internet Advisory... Open Internet rules, and to provide any recommendations it deems appropriate to the...

  8. 75 FR 9416 - Advisory Committee Information Hotline

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... Respiratory Therapy Devices Panel 3014512624 Circulatory System Devices Panel 3014512625 Clinical Chemistry... Central Nervous System Drugs Advisory Committee 3014512543 Pharmaceutical Science & Clinical Pharmacology... current information available about any particular advisory committee meeting, this system will...

  9. 77 FR 66476 - National Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-05

    ... National Advisory Council will meet by teleconference on Monday, November 19, 2012. The meeting will be open to the public. DATES: The National Advisory Council will meet Monday, November 19, 2012, from...

  10. 76 FR 56454 - Consumer Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... COMMISSION Consumer Advisory Committee Meeting AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (Committee). The purpose of the Committee is to make recommendations to the Commission regarding...

  11. 75 FR 33305 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding...

  12. 75 FR 9898 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-04

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (``Committee''). The purpose of the ] Committee is to make recommendations to the Commission regarding...

  13. 77 FR 55214 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date, time, and agenda of its Consumer Advisory Committee... within the jurisdiction of the Commission and to facilitate the participation of all consumers...

  14. 76 FR 3633 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-20

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: This document announces the rechartering of the Consumer Advisory Committee (hereinafter ``the... ``Commission'') regarding consumer issues within the jurisdiction of the Commission and to facilitate...

  15. 76 FR 45570 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-29

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces appointment of members and chairperson to its Consumer Advisory Committee... consumers in proceedings before the Commission. DATES: The meeting of the Committee will take place...

  16. 76 FR 65726 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-24

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date, time, and agenda of its Consumer Advisory Committee... within the jurisdiction of the Commission and to facilitate the participation of all consumers...

  17. 75 FR 41863 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding...

  18. 78 FR 54629 - Consumer Advisory Board meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ... From the Federal Register Online via the Government Publishing Office CONSUMER FINANCIAL PROTECTION BUREAU Consumer Advisory Board meeting AGENCY: Bureau of Consumer Financial Protection. ACTION... Consumer Advisory Board (``CAB'' or ``Board'') of the Consumer Financial Protection Bureau (Bureau)....

  19. 75 FR 63830 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding...

  20. 75 FR 4819 - Consumer Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... COMMISSION Consumer Advisory Committee AGENCY: Federal Communications Commission. ACTION: Notice. SUMMARY: The Commission announces the next meeting date and agenda of its Consumer Advisory Committee (``Committee''). The purpose of the Committee is to make recommendations to the Commission regarding...

  1. 5 CFR 2636.103 - Advisory opinions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... receive compensation for teaching. An advisory opinion issued under this section may not be substituted... conduct that is indistinguishable in all material aspects from the conduct described in the advisory...

  2. Aerospace Safety Advisory Panel

    NASA Astrophysics Data System (ADS)

    1993-03-01

    The Aerospace Safety Advisory Panel (ASAP) provided oversight on the safety aspects of many NASA programs. In addition, ASAP undertook three special studies. At the request of the Administrator, the panel assessed the requirements for an assured crew return vehicle (ACRV) for the space station and reviewed the organization of the safety and mission quality function within NASA. At the behest of Congress, the panel formed an independent, ad hoc working group to examine the safety and reliability of the space shuttle main engine. Section 2 presents findings and recommendations. Section 3 consists of information in support of these findings and recommendations. Appendices A, B, C, and D, respectively, cover the panel membership, the NASA response to the findings and recommendations in the March 1992 report, a chronology of the panel's activities during the reporting period, and the entire ACRV study report.

  3. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The Aerospace Safety Advisory Panel (ASAP) provided oversight on the safety aspects of many NASA programs. In addition, ASAP undertook three special studies. At the request of the Administrator, the panel assessed the requirements for an assured crew return vehicle (ACRV) for the space station and reviewed the organization of the safety and mission quality function within NASA. At the behest of Congress, the panel formed an independent, ad hoc working group to examine the safety and reliability of the space shuttle main engine. Section 2 presents findings and recommendations. Section 3 consists of information in support of these findings and recommendations. Appendices A, B, C, and D, respectively, cover the panel membership, the NASA response to the findings and recommendations in the March 1992 report, a chronology of the panel's activities during the reporting period, and the entire ACRV study report.

  4. Atmospheric Release Advisory Capability

    SciTech Connect

    Dickerson, M.H.; Gudiksen, P.H.; Sullivan, T.J.

    1983-02-01

    The Atmospheric Release Advisory Capability (ARAC) project is a Department of Energy (DOE) sponsored real-time emergency response service available for use by both federal and state agencies in case of a potential or actual atmospheric release of nuclear material. The project, initiated in 1972, is currently evolving from the research and development phase to full operation. Plans are underway to expand the existing capability to continuous operation by 1984 and to establish a National ARAC Center (NARAC) by 1988. This report describes the ARAC system, its utilization during the past two years, and plans for its expansion during the next five to six years. An integral part of this expansion is due to a very important and crucial effort sponsored by the Defense Nuclear Agency to extend the ARAC service to approximately 45 Department of Defense (DOD) sites throughout the continental US over the next three years.

  5. 76 FR 61118 - Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS) Meeting of the ACRS Subcommittee on Advanced Boiling Water Reactor; Notice of Meeting The ACRS Subcommittee on Advanced Boiling Water Reactor...

  6. 21 CFR 10.85 - Advisory opinions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... amendment or revocation of the advisory opinion involved will be expedited. (g) An advisory opinion may be amended or revoked at any time after it has been issued. Notice of amendment or revocation will be given... continued acceptance. Whenever possible, an amended or revoked advisory opinion will state when action...

  7. 78 FR 49543 - Towing Safety Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... SECURITY Coast Guard Towing Safety Advisory Committee AGENCY: Coast Guard, DHS. ACTION: Committee Management; Notice of Federal Advisory Committee Meeting. SUMMARY: The Towing Safety Advisory Committee (TSAC... related to shallow draft inland, coastal waterway navigation and towing safety. The meetings will be...

  8. Advisory Teacher Service in Queensland Primary Schools.

    ERIC Educational Resources Information Center

    Varley, Peter J.; Cumming, Joy

    The aim of this study was to obtain information about how advisory teachers and persons within schools perceive the operation of the Advisory Teacher Service inaugurated in the Queensland State Department of Education in 1970. The service was provided so that advisory teachers would visit primary schools on invitation of the principal and help…

  9. 76 FR 10577 - Electricity Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-25

    ... Electricity Advisory Committee Meeting AGENCY: Office of Electricity Delivery and Energy Reliability... reestablished Electricity Advisory Committee (EAC). The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat... of Electricity Delivery and Energy Reliability, U.S. Department of Energy, Forrestal Building,...

  10. 75 FR 61454 - Electricity Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-05

    ... Electricity Advisory Committee AGENCY: Department of Energy, Office of Electricity Delivery and Energy...-established DOE Electricity Advisory Committee. The Federal Advisory Committee Act (Pub. L. 92-463, 86 Stat...: David Meyer, Designated Federal Officer, Office of Electricity Delivery and Energy Reliability,...

  11. 76 FR 23845 - Arts Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... From the Federal Register Online via the Government Publishing Office NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory Panel Pursuant to Section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), as amended, notice is hereby given that one meeting of the Arts Advisory Panel to the...

  12. 76 FR 21772 - Navigation Safety Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ... SECURITY Coast Guard Navigation Safety Advisory Council AGENCY: Coast Guard, DHS. ACTION: Notice of Federal Advisory Committee Meeting. SUMMARY: The Navigation Safety Advisory Council (NAVSAC) will meet on May 4-5...; including the Inland and International Rules of the Road, navigation regulations and equipment,...

  13. 72 FR 27281 - Forestry Research Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2007-05-15

    ...; ] DEPARTMENT OF AGRICULTURE Office of the Secretary Forestry Research Advisory Council AGENCY: Office of the Secretary, USDA. ACTION: Notice; solicitation for membership to the Forestry Research Advisory Council... Forestry Research Advisory Council. DATES: Nominations must be received on or before July 16, 2007. Send...

  14. 76 FR 30955 - Invasive Species Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... Office of the Secretary Invasive Species Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of public meetings of the Invasive Species Advisory Committee. SUMMARY: Pursuant to the provisions of the Federal Advisory Committee Act, notice is hereby given of meetings of the Invasive...

  15. 77 FR 4238 - Advisory Committee Management

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... Part 8 RIN 1400-AC64 Advisory Committee Management AGENCY: Department of State. ACTION: Final rule... establish uniform administrative guidelines and management controls for advisory committees established by... of Subjects in 22 CFR Part 8 Advisory Committee Management. Accordingly, under the authority of 22 U...

  16. 76 FR 63664 - Arts Advisory Panel

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Doc No: 2011-26421] NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES National Endowment for the Arts Arts Advisory Panel Pursuant to Section 10(a)(2) of the Federal Advisory Committee Act (Pub. L. 92-463), as amended, notice is hereby given that thirteen meetings of the Arts Advisory Panel to the...

  17. 75 FR 8916 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-26

    ... Forest Service Ketchikan Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in Ketchikan, Alaska, March 31, 2010..., Alaska. Send written comments to Ketchikan Resource Advisory Committee, do District Ranger, USDA Forest...

  18. 76 FR 31578 - Siskiyou Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    ... Forest Service Siskiyou Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Siskiou Resource Advisory Committee will meet in Smith River, California. The..., OR Resource Advisory committee for Josephine, Coos and Curry Counties; review and recommend FY2012...

  19. 75 FR 54846 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... Forest Service Ketchikan Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in Ketchikan, Alaska, September 30..., Ketchikan, Alaska. Send written comments to Ketchikan Resource Advisory Committee, c/o District Ranger, USDA...

  20. 77 FR 26518 - Public Advisory Committees

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... United States Patent and Trademark Office Public Advisory Committees AGENCY: United States Patent and... three (3)-year terms. The Public Advisory Committee members must be United States citizens and represent..., which, among other things, established two Public Advisory Committees to review the policies,...

  1. 77 FR 40032 - Methane Hydrate Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-06

    ... Methane Hydrate Advisory Committee AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of open meeting. SUMMARY: This notice announces a meeting of the Methane Hydrate Advisory Committee.... SUPPLEMENTARY INFORMATION: Purpose of the Committee: The purpose of the Methane Hydrate Advisory Committee is...

  2. 48 CFR 401.371 - AGAR Advisories.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 4 2013-10-01 2013-10-01 false AGAR Advisories. 401.371... ACQUISITION REGULATION SYSTEM Agency Acquisition Regulations 401.371 AGAR Advisories. The SPE may issue AGAR Advisories, consistent with the policies of the FAR and the AGAR, for the following purposes: (a) To...

  3. 48 CFR 401.371 - AGAR Advisories.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 4 2014-10-01 2014-10-01 false AGAR Advisories. 401.371... ACQUISITION REGULATION SYSTEM Agency Acquisition Regulations 401.371 AGAR Advisories. The SPE may issue AGAR Advisories, consistent with the policies of the FAR and the AGAR, for the following purposes: (a) To...

  4. 48 CFR 401.371 - AGAR Advisories.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false AGAR Advisories. 401.371... ACQUISITION REGULATION SYSTEM Agency Acquisition Regulations 401.371 AGAR Advisories. The SPE may issue AGAR Advisories, consistent with the policies of the FAR and the AGAR, for the following purposes: (a) To...

  5. 48 CFR 401.371 - AGAR Advisories.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 4 2011-10-01 2011-10-01 false AGAR Advisories. 401.371... ACQUISITION REGULATION SYSTEM Agency Acquisition Regulations 401.371 AGAR Advisories. The SPE may issue AGAR Advisories, consistent with the policies of the FAR and the AGAR, for the following purposes: (a) To...

  6. 48 CFR 401.371 - AGAR Advisories.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 4 2012-10-01 2012-10-01 false AGAR Advisories. 401.371... ACQUISITION REGULATION SYSTEM Agency Acquisition Regulations 401.371 AGAR Advisories. The SPE may issue AGAR Advisories, consistent with the policies of the FAR and the AGAR, for the following purposes: (a) To...

  7. 76 FR 23537 - Resource Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-27

    ... Resource Advisory Committee Meeting AGENCY: Forest Service, USDA. ACTION: Notice of Public Meeting, Sabine National Forest Resource Advisory Committee. SUMMARY: In accordance with the Secure Rural Schools and..., Sabine National Forest Resource Advisory Committee (RAC) meeting will meet as indicated below. DATES:...

  8. 75 FR 46902 - Ketchikan Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... Forest Service Ketchikan Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Ketchikan Resource Advisory Committee will meet in Ketchikan, Alaska, August 18..., Ketchikan, Alaska. Send written comments to Ketchikan Resource Advisory Committee, c/o District Ranger,...

  9. 75 FR 33241 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-11

    ... Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in Sedona, Arizona. The purpose of... Smith, RAC Coordinator, Coconino Resource Advisory Committee, c/o Forest Service, USDA, 1824 S....

  10. 75 FR 10460 - Yakutat Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-08

    ... Forest Service Yakutat Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Yakutat Resource Advisory Committee will meet in Yakutat, Alaska. The purpose of the meeting is to continue business of the Yakutat Resource Advisory Committee. The committee was formed...

  11. 75 FR 61693 - Coconino Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-06

    ... Forest Service Coconino Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Coconino Resource Advisory Committee will meet in Flagstaff, Arizona. The purpose of the meeting is to receive training on Resource Advisory Committees and National Environmental...

  12. 78 FR 45496 - Flathead Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-29

    ... Forest Service Flathead Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meetings. SUMMARY: The Flathead Resource Advisory Committee will meet in Kalispell, Montana on the dates..., 2013--4:00 p.m. to 6:30 p.m. All Resource Advisory Committee meetings are subject to change...

  13. 75 FR 6056 - National Geospatial Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... Office of the Secretary National Geospatial Advisory Committee AGENCY: Office of the Secretary, Interior. ACTION: Notice of renewal of National Geospatial Advisory Committee. SUMMARY: This notice is published in... given that the Secretary of the Interior ] has renewed the National Geospatial Advisory Committee. The...

  14. 75 FR 53707 - Homeland Security Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-01

    ...-53708] [FR Doc No: 2010-21787] DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2010-0074] Homeland Security Advisory Council AGENCY: The Office of Policy, DHS. ACTION: Notice of Open Teleconference Federal Advisory Committee Meeting. SUMMARY: The Homeland Security Advisory Council (HSAC) will meet via...

  15. 76 FR 2672 - Science Advisory Board Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... National Oceanic and Atmospheric Administration Science Advisory Board Meeting AGENCY: Office of Oceanic... agenda of a forthcoming meeting of the NOAA Science Advisory Board. The members will discuss and provide... Decker, Executive Director, Science Advisory Board, NOAA, Rm. 11230, 1315 East-West Highway, Silver...

  16. 76 FR 57023 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... National Oceanic and Atmospheric Administration (NOAA) Science Advisory Board AGENCY: Office of Oceanic and... agenda of a forthcoming meeting of the NOAA Science Advisory Board. The members will discuss and provide..., but may not be reviewed prior to the meeting date. SUPPLEMENTARY INFORMATION: The Science Advisory...

  17. 77 FR 476 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... National Oceanic and Atmospheric Administration (NOAA) Science Advisory Board AGENCY: Office of Oceanic and... agenda of a forthcoming meeting of the NOAA Science Advisory Board. The members will discuss and provide... be reviewed prior to the meeting date. SUPPLEMENTARY INFORMATION: The Science Advisory Board (SAB...

  18. 78 FR 68037 - Science Advisory Board (SAB)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-13

    ... National Oceanic and Atmospheric Administration Science Advisory Board (SAB) AGENCY: Office of Oceanic and... the NOAA Science Advisory Board (SAB) was published in the Federal Register on October 2, 2013.... Cynthia Decker, Executive Director, Science Advisory Board, NOAA, Rm. 11230, 1315 East-West Highway...

  19. 77 FR 58356 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... National Oceanic and Atmospheric Administration Science Advisory Board AGENCY: Office of Oceanic and... agenda of a forthcoming meeting of the NOAA Science Advisory Board. The members will discuss and provide... the meeting date. SUPPLEMENTARY INFORMATION: The Science Advisory Board (SAB) was established by a...

  20. 75 FR 54854 - Science Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-09

    ... National Oceanic and Atmospheric Administration Science Advisory Board AGENCY: Office of Oceanic and... agenda of a forthcoming meeting of the NOAA Science Advisory Board. The members will discuss and provide.... Cynthia Decker, Executive Director, Science Advisory Board, NOAA, Rm. 11230, 1315 East-West Highway...

  1. 75 FR 38086 - Technology Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... COMMISSION Technology Advisory Committee Meeting The Commodity Futures Trading Commission's (``Commission'') Technology Advisory Committee will conduct a meeting on Wednesday, July 14, 2010, beginning at 1 p.m. The...://www.cftc.gov . This will be the first meeting of the reestablished Technology Advisory...

  2. 78 FR 11899 - Invasive Species Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-20

    ... Office of the Secretary Invasive Species Advisory Committee AGENCY: Office of the Secretary, Interior... Invasive Species Advisory Committee. The document contained incorrect dates. This document corrects those.... Meeting of the Invasive Species Advisory Committee (OPEN): Thursday, March 7, 2013 through Friday, March 8...

  3. 76 FR 2646 - 2010 Census Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... Bureau of the Census 2010 Census Advisory Committee AGENCY: Bureau of the Census, Department of Commerce. ACTION: Notice of public meeting. SUMMARY: The Bureau of the Census (Census Bureau) is giving notice of a meeting of the 2010 Census Advisory Committee. The Committee will address advisory committee...

  4. 77 FR 16894 - Financial Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-22

    ... Financial Research Advisory Committee AGENCY: Office of Financial Research, Treasury. ACTION: Notice of establishment of the Financial Research Advisory Committee and solicitation of applications for Committee... the Financial Research Advisory Committee. A Charter for the Committee has been prepared and will...

  5. Linchpins or Lost Time: Creating Effective Advisories

    ERIC Educational Resources Information Center

    Johnson, Bil

    2009-01-01

    That advisories in secondary schools are fairly pervasive around the country may be one of the great unintended consequences of the Coalition of Essential Schools (CES) reform effort. While no CES Common Principle explicitly states that advisories should exist in schools, as Coalition Schools evolved, advisories became one of the logical ways for…

  6. 78 FR 67379 - Chemical Transportation Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ... SECURITY Coast Guard Chemical Transportation Advisory Committee AGENCY: Coast Guard, DHS. ACTION: Committee Management; Notice of Federal Advisory Committee Meeting. SUMMARY: The Chemical Transportation Advisory... Washington, DC, to discuss marine transportation of hazardous materials. The meetings will be open to the...

  7. 76 FR 34240 - Chemical Transportation Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-13

    ... SECURITY Coast Guard Chemical Transportation Advisory Committee AGENCY: Coast Guard, DHS. ACTION: Committee... that the establishment of the Chemical Transportation Advisory Committee (CTAC) is necessary and in the...: Chemical Transportation Advisory Committee. ADDRESSES: If you desire to submit comments on this action...

  8. 78 FR 55278 - Chemical Transportation Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... SECURITY Coast Guard Chemical Transportation Advisory Committee AGENCY: Coast Guard, DHS. ACTION: Committee... that the re- establishment of the Chemical Transportation Advisory Committee (CTAC) is necessary and in... Committee: Chemical Transportation Advisory Committee. ADDRESSES: If you desire to submit comments on this...

  9. 78 FR 23773 - Chemical Transportation Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-22

    ... SECURITY Coast Guard Chemical Transportation Advisory Committee AGENCY: Coast Guard, DHS. ACTION: Committee Management; Notice of Federal Advisory Committee Meeting. SUMMARY: The Chemical Transportation Advisory..., VA, to discuss marine transportation of hazardous materials. The meetings will be open to the public...

  10. 77 FR 15091 - Environmental Management Advisory Board

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-14

    ... Environmental Management Advisory Board AGENCY: Department of Energy. ACTION: Notice of Solicitation of Nominations for Appointment as a member of the Environmental Management Advisory Board. SUMMARY: In accordance... soliciting nominations for candidates to fill vacancies on the Environmental Management Advisory Board...

  11. Advanced Ground Systems Maintenance Enterprise Architecture Project

    NASA Technical Reports Server (NTRS)

    Perotti, Jose M. (Compiler)

    2015-01-01

    The project implements an architecture for delivery of integrated health management capabilities for the 21st Century launch complex. The delivered capabilities include anomaly detection, fault isolation, prognostics and physics based diagnostics.

  12. Advanced figure sensor operations and maintenance manual

    NASA Technical Reports Server (NTRS)

    Robertson, H. J.

    1972-01-01

    This manual contains procedures for installing, operating, and maintaining the optical figure sensor and its associated electronic controls. The optical figure sensor, a system of integrated components, comprises: (1) a phase measuring modified interferometer employing a single frequency 6328 A laser, and a Vidissector; (2) a two-axis automatic thermal compensation control mount; (3) a five degree of freedom manual adjustment stand; and (4) a control console. This instrument provides real time output data of optical figure errors for spherical mirrors, and is also capable of measuring aspherical mirrors if a null corrector is added.

  13. Advanced Ground Systems Maintenance Enterprise Architecture Project

    NASA Technical Reports Server (NTRS)

    Harp, Janicce Leshay

    2014-01-01

    The project implements an architecture for delivery of integrated health management capabilities for the 21st Century launch complex. Capabilities include anomaly detection, fault isolation, prognostics and physics-based diagnostics.

  14. Advanced Ground Systems Maintenance Prognostics Project

    NASA Technical Reports Server (NTRS)

    Harp, Janicce Leshay

    2014-01-01

    The project implements prognostics capabilities to predict when a component, system or subsystem will no longer meet desired functional or performance criteria, called the "end of life." The capability also provides an assessment of the "remaining useful life" of a hardware component.

  15. Facilities maintenance handbook

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This handbook is a guide for facilities maintenance managers. Its objective is to set minimum facilities maintenance standards. It also provides recommendations on how to meet the standards to ensure that NASA maintains its facilities in a manner that protects and preserves its investment in the facilities in a cost-effective manner while safely and efficiently performing its mission. This handbook implements NMI 8831.1, which states NASA facilities maintenance policy and assigns organizational responsibilities for the management of facilities maintenance activities on all properties under NASA jurisdiction. It is a reference for facilities maintenance managers, not a step-by-step procedural manual. Because of the differences in NASA Field Installation organizations, this handbook does not assume or recommend a typical facilities maintenance organization. Instead, it uses a systems approach to describe the functions that should be included in any facilities maintenance management system, regardless of its organizational structure. For documents referenced in the handbook, the most recent version of the documents is applicable. This handbook is divided into three parts: Part 1 specifies common definitions and facilities maintenance requirements and amplifies the policy requirements contained in NMI 8831. 1; Part 2 provides guidance on how to meet the requirements of Part 1, containing recommendations only; Part 3 contains general facilities maintenance information. One objective of this handbook is to fix commonality of facilities maintenance definitions among the Centers. This will permit the application of uniform measures of facilities conditions, of the relationship between current replacement value and maintenance resources required, and of the backlog of deferred facilities maintenance. The utilization of facilities maintenance system functions will allow the Centers to quantitatively define maintenance objectives in common terms, prepare work plans, and

  16. Maintenance therapy in multiple myeloma

    PubMed Central

    Mewawalla, Prerna; Chilkulwar, Abhishek

    2016-01-01

    Despite recent advances, multiple myeloma remains an incurable disease. Induction therapy followed by autologous transplantation has become the standard of care. The idea of maintenance therapy in multiple myeloma is not new. Starting with chemotherapy in 1975, to interferon in 1998, to novel agents recently, a multitude of agents have been explored in patients with multiple myeloma. In spite of the novel agents, multiple myeloma continues to be an incurable disease with the progression-free survival after autologous transplant rarely exceeding 3 years. The goal of using maintenance therapy has been to improve the outcomes following autologous transplantation by increasing the progression-free survival, deepening remissions and perhaps increasing overall survival. It has been shown that patients with a stringent complete response (CR) have a better outcome [Kapoor et al. 2013]. It is becoming increasingly common to check minimal residual disease (MRD) as a means of assessing depth of response. It has also been shown that patients with no MRD have not only a better progression-free survival but also a better overall survival compared with patients who are MRD positive. This makes it even more important to find agents for maintenance therapy, which can further deepen and maintain responses. Here, we present a comprehensive review of the agents studied as maintenance for multiple myeloma and their efficacy, both in terms of overall survival, progression-free survival and toxicity. PMID:28203343

  17. Maintenance Management System

    DTIC Science & Technology

    1990-06-01

    maintenance opera- tions. d. Available national maintenance management system (MMS) software be utilized to develop the planning, organizing...portland cement concrete pavements to level and realign faulted areas between slabs or craks within the slab by grinding the high side. MAINTENANCE ITEM

  18. Asphalt in Pavement Maintenance.

    ERIC Educational Resources Information Center

    Asphalt Inst., College Park, MD.

    Maintenance methods that can be used equally well in all regions of the country have been developed for the use of asphalt in pavement maintenance. Specific information covering methods, equipment and terminology that applies to the use of asphalt in the maintenance of all types of pavement structures, including shoulders, is provided. In many…

  19. Defer Maintenance, Invite Disaster

    ERIC Educational Resources Information Center

    Bowman, William W.

    1977-01-01

    An AGB- and NACUBO-sponsored survey showed that "wish lists" are accumulating overdue major maintenance projects because energy costs are consuming physical plant budgets. Problem areas are discussed: budget "guesstimation," preventive maintenance, deferred maintenance inventory, the APPA accounting format, resource allocation,…

  20. Microform Reader Maintenance.

    ERIC Educational Resources Information Center

    Hall, Hal W.; Michaels, George H.

    1985-01-01

    Describes experiences in organizing a program of microform reader and reader/printer maintenance at Texas A & M's Sterling C. Evans Library and offers guidelines for regular machine maintenance and repair. Guidelines discussed relate to maintenance philosophy, general machine cleaning, troubleshooting, service contracts, supplies,…

  1. Light Vehicle Preventive Maintenance.

    ERIC Educational Resources Information Center

    Marine Corps Inst., Washington, DC.

    This correspondence course, originally developed for the Marine Corps, is designed to instruct students in the performance of preventive maintenance on motor vehicles. Instructional materials are presented in three chapters as follows: (1) Major Maintenance Areas (maintenance system, tires, batteries, cooling systems, and vehicle lubrication; (2)…

  2. Maintenance for the Millennium: Another Approach

    SciTech Connect

    Sculthorpe, Barruy R.

    2002-07-01

    Nuclear units nationwide are struggling to increase plant reliability and availability while at the same time reduce their operating and maintenance costs. Some very costly investments have been made in programs such as Reliability Centered Maintenance [RCM]. Florida Power and Light's approach at the St. Lucie Nuclear Plant has taken a slightly different approach. Building on our knowledge of the RCM process and an already existing 'World Class' Predictive Maintenance Program, a 'Condition-Based' Maintenance Program that takes advantage of the RCM philosophy and our toolbox full of advanced and highly successful predictive maintenance technologies. These tools currently consist of vibration analysis, lubricant analysis (both physical property and wear metals analysis, thermographic analysis, motor current signature analysis, tribology and process parameter trending. All employed with the intent to evaluate a machines health. This machine health check allows the forecasting of future preventative maintenance [PM's] tasks and the revision of existing PM's to maximize machine performance and eliminate 'no-value-added' maintenance activities/costs. Within the last year, the Condition-Based Maintenance Program has produced a cost saving of approximately $1.5 million dollars. As the program matures, these cost savings will accumulate well into the millennium. (authors)

  3. Effectiveness of maintenance treatments for nonsmall cell lung cancer

    PubMed Central

    Eadens, Matthew J; Robinson, Steven I; Price, Katharine AR

    2011-01-01

    Maintenance therapy for advanced nonsmall cell lung cancer has shown some clinical benefit for patients by improving progression-free survival and, to a lesser extent, overall survival. Two main strategies exist for maintenance therapy, ie, continuation and switch maintenance. Continuation maintenance involves the continued use of one of the induction drugs beyond 4–6 cycles of initial treatment. Switch maintenance utilizes a third agent initiated after first-line chemotherapy. Both cytotoxic agents and targeted agents have been studied. Switch maintenance therapy with pemetrexed in nonsquamous tumors and erlotinib appear to show the most clear clinical benefit. Continuation maintenance with bevacizumab has shown improvement in progression-free survival. Data concerning the role of cetuximab for maintenance is conflicting. Toxicity, quality of life, and cost are important confounding issues that need to be considered. Several ongoing Phase III trials are investigating strategies to improve on the current agents as well as testing promising new therapies. PMID:28210116

  4. 22 CFR 214.32 - Calling of advisory committee meetings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Calling of advisory committee meetings. 214.32 Section 214.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 214.32 Calling of advisory committee meetings. (a) No advisory committee...

  5. 22 CFR 214.32 - Calling of advisory committee meetings.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Calling of advisory committee meetings. 214.32 Section 214.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 214.32 Calling of advisory committee meetings. (a) No advisory committee...

  6. 21 CFR 14.90 - Ad hoc advisory committee members.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Ad hoc advisory committee members. 14.90 Section... PUBLIC HEARING BEFORE A PUBLIC ADVISORY COMMITTEE Members of Advisory Committees § 14.90 Ad hoc advisory committee members. In selecting members of an ad hoc advisory committee, the Commissioner may use...

  7. 21 CFR 14.90 - Ad hoc advisory committee members.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Ad hoc advisory committee members. 14.90 Section... PUBLIC HEARING BEFORE A PUBLIC ADVISORY COMMITTEE Members of Advisory Committees § 14.90 Ad hoc advisory committee members. In selecting members of an ad hoc advisory committee, the Commissioner may use...

  8. 22 CFR 214.32 - Calling of advisory committee meetings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Calling of advisory committee meetings. 214.32 Section 214.32 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT ADVISORY COMMITTEE MANAGEMENT Operation of Advisory Committees § 214.32 Calling of advisory committee meetings. (a) No advisory...

  9. Health advisory for zinc chloride

    SciTech Connect

    Donohue, J.M.; Gordon, L.; Kirman, C.; Roberts, W.C.

    1992-09-01

    The Health Advisory (HA) provides information on the health effects, analytical methodology and treatment technology that would be useful in dealing with zinc chloride contamination of drinking water. Based on available toxicity data the HA values for zinc chloride are given. Zinc chloride is classified as Group D, not classifiable as to human carcinogenicity. Health Advisories describe nonregulatory concentrations of drinking water contaminants at which adverse health effects would not be anticipated to occur over specific exposure durations. The HAs, developed by the US Environmental Protection Agency, Office of Water (OW), are not legally enforceable Federal standards and are subject to change as new information becomes available. Health Advisories are developed for One-day, Ten-day, Longer-term and Lifetime exposures based on data describing noncarcinogenic end points of toxicity. For those substances that are known or probable human carcinogens, according to the EPA classification scheme, Lifetime HAs are not recommended.

  10. Robots for Aircraft Maintenance

    NASA Technical Reports Server (NTRS)

    1993-01-01

    Marshall Space Flight Center charged USBI (now Pratt & Whitney) with the task of developing an advanced stripping system based on hydroblasting to strip paint and thermal protection material from Space Shuttle solid rocket boosters. A robot, mounted on a transportable platform, controls the waterjet angle, water pressure and flow rate. This technology, now known as ARMS, has found commercial applications in the removal of coatings from jet engine components. The system is significantly faster than manual procedures and uses only minimal labor. Because the amount of "substrate" lost is minimal, the life of the component is extended. The need for toxic chemicals is reduced, as is waste disposal and human protection equipment. Users of the ARMS work cell include Delta Air Lines and the Air Force, which later contracted with USBI for development of a Large Aircraft Paint Stripping system (LARPS). LARPS' advantages are similar to ARMS, and it has enormous potential in military and civil aircraft maintenance. The technology may also be adapted to aircraft painting, aircraft inspection techniques and paint stripping of large objects like ships and railcars.

  11. Aerospace safety advisory panel

    NASA Technical Reports Server (NTRS)

    1995-01-01

    The Aerospace Safety Advisory Panel (ASAP) monitored NASA's activities and provided feedback to the NASA Administrator, other NASA officials and Congress throughout the year. Particular attention was paid to the Space Shuttle, its launch processing and planned and potential safety improvements. The Panel monitored Space Shuttle processing at the Kennedy Space Center (KSC) and will continue to follow it as personnel reductions are implemented. There is particular concern that upgrades in hardware, software, and operations with the potential for significant risk reduction not be overlooked due to the extraordinary budget pressures facing the agency. The authorization of all of the Space Shuttle Main Engine (SSME) Block II components portends future Space Shuttle operations at lower risk levels and with greater margins for handling unplanned ascent events. Throughout the year, the Panel attempted to monitor the safety activities related to the Russian involvement in both space and aeronautics programs. This proved difficult as the working relationships between NASA and the Russians were still being defined as the year unfolded. NASA's concern for the unique safety problems inherent in a multi-national endeavor appears appropriate. Actions are underway or contemplated which should be capable of identifying and rectifying problem areas. The balance of this report presents 'Findings and Recommendations' (Section 2), 'Information in Support of Findings and Recommendations' (Section 3) and Appendices describing Panel membership, the NASA response to the March 1994 ASAP report, and a chronology of the panel's activities during the reporting period (Section 4).

  12. Aerospace Safety Advisory Panel

    NASA Astrophysics Data System (ADS)

    1989-03-01

    This report provides findings, conclusions and recommendations regarding the National Space Transportation System (NSTS), the Space Station Freedom Program (SSFP), aeronautical projects and other areas of NASA activities. The main focus of the Aerospace Safety Advisory Panel (ASAP) during 1988 has been monitoring and advising NASA and its contractors on the Space Transportation System (STS) recovery program. NASA efforts have restored the flight program with a much better management organization, safety and quality assurance organizations, and management communication system. The NASA National Space Transportation System (NSTS) organization in conjunction with its prime contractors should be encouraged to continue development and incorporation of appropriate design and operational improvements which will further reduce risk. The data from each Shuttle flight should be used to determine if affordable design and/or operational improvements could further increase safety. The review of Critical Items (CILs), Failure Mode Effects and Analyses (FMEAs) and Hazard Analyses (HAs) after the Challenger accident has given the program a massive data base with which to establish a formal program with prioritized changes.

  13. Wind Advisory System

    NASA Technical Reports Server (NTRS)

    Curto, Paul A. (Inventor); Brown, Gerald E. (Inventor); Zysko, Jan A. (Inventor)

    2001-01-01

    The present invention is a two-part wind advisory system comprising a ground station at an airfield and an airborne unit placed inside an aircraft. The ground station monitors wind conditions (wind speed, wind direction, and wind gust) at the airfield and transmits the wind conditions and an airfield ID to the airborne unit. The airborne unit identifies the airfield by comparing the received airfield ID with airfield IDs stored in a database. The airborne unit also calculates the headwind and crosswind for each runway in both directions at the airfield using the received wind conditions and runway information stored in the database. The airborne unit then determines a recommended runway for takeoff and landing operations of the aircraft based on th runway having the greatest headwind value and displays the airfield ID, wind conditions, and recommended runway to the pilot. Another embodiment of the present invention includes a wireless internet based airborne unit in which the airborne unit can receive the wind conditions from the ground station over the internet.

  14. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This report provides findings, conclusions and recommendations regarding the National Space Transportation System (NSTS), the Space Station Freedom Program (SSFP), aeronautical projects and other areas of NASA activities. The main focus of the Aerospace Safety Advisory Panel (ASAP) during 1988 has been monitoring and advising NASA and its contractors on the Space Transportation System (STS) recovery program. NASA efforts have restored the flight program with a much better management organization, safety and quality assurance organizations, and management communication system. The NASA National Space Transportation System (NSTS) organization in conjunction with its prime contractors should be encouraged to continue development and incorporation of appropriate design and operational improvements which will further reduce risk. The data from each Shuttle flight should be used to determine if affordable design and/or operational improvements could further increase safety. The review of Critical Items (CILs), Failure Mode Effects and Analyses (FMEAs) and Hazard Analyses (HAs) after the Challenger accident has given the program a massive data base with which to establish a formal program with prioritized changes.

  15. 78 FR 12059 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ...., Washington, DC 20554. FOR FURTHER INFORMATION CONTACT: Walter Johnston, Chief, Electromagnetic Compatibility Division, 202-418-0807; Walter.Johnston@FCC.gov . SUPPLEMENTARY INFORMATION: The FCC Technological Advisory.../ . The public may submit written comments before the meeting to: Walter Johnston, the FCC's...

  16. 77 FR 52332 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-29

    ..., DC 20554. FOR FURTHER INFORMATION CONTACT: Walter Johnston, Chief, Electromagnetic Compatibility Division, 202-418-0807; Walter.Johnston@FCC.gov . SUPPLEMENTARY INFORMATION: The FCC Technological Advisory... public may submit written comments before the meeting to: Walter Johnston, the FCC's Designated...

  17. 78 FR 55255 - Federal Advisory Committee Act; Technological Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... INFORMATION CONTACT: Walter Johnston, Chief, Electromagnetic Compatibility Division, 202-418-0807; Walter.Johnston@FCC.gov . SUPPLEMENTARY INFORMATION: The FCC Technological Advisory Council will discuss progress...://www.fcc.gov/live/ . The public may submit written comments before the meeting to: Walter Johnston,...

  18. 76 FR 44376 - Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS), Meeting of the ACRS Subcommittee on U.S. Advanced Pressurized Water Reactor; Notice of Meeting The ACRS Subcommittee on U.S. Advanced Pressurized Water Reactor (US-APWR) will hold a meeting on Augus...

  19. Innovation for maintenance technology improvements

    NASA Technical Reports Server (NTRS)

    Shives, T. R. (Editor); Willard, W. A. (Editor)

    1982-01-01

    A group of 34 submitted entries (32 papers and 2 abstracts) from the 33rd meeting of the Mechanical Failures Prevention Group whose subject was maintenance technology improvement through innovation. Areas of special emphasis included maintenance concepts, maintenance analysis systems, improved maintenance processes, innovative maintenance diagnostics and maintenance indicators, and technology improvements for power plant applications.

  20. 75 FR 28275 - Homeland Security Science and Technology Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ... SECURITY Homeland Security Science and Technology Advisory Committee AGENCY: Science and Technology...: On April 12, 2010, the Homeland Security Science and Technology Advisory Committee announced in the... supplements that original meeting notice. DATES: The Homeland Security Science and Technology Advisory...

  1. 77 FR 55201 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-07

    ... Biological and Environmental Research Advisory Committee AGENCY: Department of Energy, Office of Science... and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee Act (Pub. L. 92... Science, Office of Biological and Environmental Research, SC-23/Germantown Building, 1000 Independence...

  2. 78 FR 12043 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... Biological and Environmental Research Advisory Committee AGENCY: Office of Science, Department of Energy... and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee Act (Pub. L. No... Science, Office of Biological and Environmental Research, SC-23/Germantown Building, 1000 Independence...

  3. 76 FR 31319 - Biological and Environmental Research Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... Biological and Environmental Research Advisory Committee AGENCY: Office of Science, Department of Energy... the Biological and Environmental Research Advisory Committee (BERAC). The Federal Advisory Committee..., Office of Biological and Environmental Research, SC-23/Germantown Building, 1000 Independence Avenue, SW...

  4. 78 FR 12056 - National Environmental Justice Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... AGENCY National Environmental Justice Advisory Council AGENCY: Environmental Protection Agency (EPA). ACTION: Request for Nominations to the National Environmental Justice Advisory Council (NEJAC). SUMMARY... candidates to be considered for appointment to its National Environmental Justice Advisory Council (NEJAC...

  5. 76 FR 19952 - Davy Crockett National Forest Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-11

    ... Davy Crockett National Forest Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of Public Meeting, Davy Crockett National Forest Resource Advisory Committee. SUMMARY: In accordance.... Department of Agriculture, Forest Service, Davy Crockett National Forest Resource Advisory Committee (RAC...

  6. 76 FR 14647 - Sabine National Forest Resource Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-17

    ...; ] DEPARTMENT OF AGRICULTURE Sabine National Forest Resource Advisory Committee Meeting AGENCY: Forest Service, USDA. ACTION: Notice of Public Meeting, Sabine National Forest Resource Advisory Committee. SUMMARY: In.... Department of Agriculture, Forest Service, Sabine National Forest Resource Advisory Committee (RAC) meeting...

  7. 77 FR 58811 - Advisory Committee on Supply Chain Competitiveness Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-24

    ... International Trade Administration Advisory Committee on Supply Chain Competitiveness Meeting AGENCY... notice announces a public meeting of the Advisory Committee on Supply Chain Competitiveness (Committee... comments may be mailed to Advisory Committee on Supply Chain Competitiveness, Office of Service...

  8. 78 FR 17640 - National Climate Assessment and Development Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... National Oceanic and Atmospheric Administration National Climate Assessment and Development Advisory... the National Climate Assessment and Development Advisory Committee (NCADAC) for a six-month period.... Decker, Designated Federal Officer, National Climate Assessment and Development Advisory Committee, NOAA...

  9. 76 FR 37312 - Fruit and Vegetable Industry Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ...; ] DEPARTMENT OF AGRICULTURE Agricultural Marketing Service Fruit and Vegetable Industry Advisory Committee... Agriculture (USDA) Fruit and Vegetable Industry Advisory Committee and a Request for Nominations. SUMMARY: The USDA intends to reestablish the Fruit and Vegetable Industry Advisory Committee (Committee). The...

  10. 77 FR 64818 - The Critical Infrastructure Partnership Advisory Council

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-23

    ... SECURITY The Critical Infrastructure Partnership Advisory Council AGENCY: National Protection and Programs Directorate, DHS. ACTION: Quarterly Critical Infrastructure Partnership Advisory Council membership update... Infrastructure Partnership Advisory Council (CIPAC) in a Federal Register Notice (71 FR 14930-14933) dated March...

  11. 78 FR 20685 - Aviation Security Advisory Committee (ASAC) Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... SECURITY Transportation Security Administration Aviation Security Advisory Committee (ASAC) Meeting AGENCY... Committee Meeting. SUMMARY: The Aviation Security Advisory Committee (ASAC) will meet in Arlington, VA. This.... L. 92-463). The Aviation Security Advisory Committee (ASAC) provides advice and...

  12. 75 FR 60493 - Aviation Rulemaking Advisory Committee; Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... Federal Aviation Administration Aviation Rulemaking Advisory Committee; Renewal AGENCY: Federal Aviation... Regulations, the FAA gives notice it has renewed the Aviation Rulemaking Advisory Committee (ARAC) for a 2..., Executive Director, Aviation Rulemaking Advisory Committee. BILLING CODE 4910-13-P...

  13. 77 FR 56909 - Aviation Rulemaking Advisory Committee (ARAC); Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-14

    ... Federal Aviation Administration Aviation Rulemaking Advisory Committee (ARAC); Renewal AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Renewal. SUMMARY: The FAA announces the charter renewal of the Aviation Rulemaking Advisory Committee (ARAC), a Federal Advisory Committee that works...

  14. 77 FR 20643 - Blood Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    ... HUMAN SERVICES Food and Drug Administration Blood Products Advisory Committee; Notice of Meeting AGENCY... public. Name of Committee: Blood Products Advisory Committee. General Function of the Committee: To... following links. Blood Products Advisory Committee Web Cast Link May 15...

  15. 76 FR 39405 - Blood Products Advisory Committee; Notice of Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-06

    ... HUMAN SERVICES Food and Drug Administration Blood Products Advisory Committee; Notice of Meeting AGENCY... public. Name of Committee: Blood Products Advisory Committee. General Function of the Committee: To... available at the following links. Blood Products Advisory Committee Day 1:...

  16. 75 FR 72863 - Motor Carrier Safety Advisory Committee Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-26

    ... Federal Motor Carrier Safety Administration Motor Carrier Safety Advisory Committee Public Meeting AGENCY: Federal Motor Carrier Safety Administration, DOT. ACTION: Notice of Motor Carrier Safety Advisory Committee Meeting. SUMMARY: FMCSA announces that the Agency's Motor Carrier Safety Advisory Committee...

  17. 75 FR 50797 - Motor Carrier Safety Advisory Committee Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-17

    ... Federal Motor Carrier Safety Administration Motor Carrier Safety Advisory Committee Public Meeting AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of Motor Carrier Safety Advisory Committee Meeting. SUMMARY: FMCSA announces that its Motor Carrier Safety Advisory Committee (MCSAC)...

  18. 75 FR 29384 - Motor Carrier Safety Advisory Committee Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-25

    ... Federal Motor Carrier Safety Administration Motor Carrier Safety Advisory Committee Public Meeting AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of Motor Carrier Safety Advisory Committee meeting. SUMMARY: FMCSA announces that its Motor Carrier Safety Advisory Committee (MCSAC)...

  19. 78 FR 53497 - Commercial Space Transportation Advisory Committee; Closed Session

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-29

    ... Federal Aviation Administration Commercial Space Transportation Advisory Committee; Closed Session AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of Commercial Space Transportation Advisory... closed session of the Commercial Space Transportation Advisory Committee (COMSTAC). The special...

  20. 75 FR 57102 - Occupational Information Development Advisory Panel Meeting; Correction

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-17

    ... ADMINISTRATION Occupational Information Development Advisory Panel Meeting; Correction AGENCY: Social Security... Occupational Information Development Advisory Panel. The document contained an incorrect timeframe for the...: Occupational Information Development Advisory Panel, Social Security Administration, 6401 Security Boulevard...

  1. 76 FR 40768 - Occupational Information Development Advisory Panel Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... ADMINISTRATION Occupational Information Development Advisory Panel Meeting AGENCY: Social Security Administration... Development Advisory Panel (panel) is a discretionary panel, established under the Federal Advisory Committee... development and testing of a content model and taxonomy, work analysis instrumentation, sampling, and data...

  2. 76 FR 70804 - Occupational Information Development Advisory Panel Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ... ADMINISTRATION Occupational Information Development Advisory Panel Meeting AGENCY: Social Security Administration... Development Advisory Panel (panel) is a discretionary panel, established under the Federal Advisory Committee... development and testing of a content model and taxonomy, work analysis instrumentation, sampling, and data...

  3. 77 FR 39511 - Meeting (Webinar) of the Federal Advisory Committee on Juvenile Justice

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... 7 p.m. ET. FOR FURTHER INFORMATION CONTACT: Robin Delany-Shabazz, Designated Federal Official, OJJDP, Robin.Delany-Shabazz@usdoj.gov , or 202-307- 9963. SUPPLEMENTARY INFORMATION: The Federal Advisory... comments in advance to Robin Delany-Shabazz, Designated Federal Official, by email to...

  4. 75 FR 39974 - NASA Advisory Council; Science Committee; Planetary Protection Subcommittee; Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... (202) 358-4118, or mnorris@nasa.gov . SUPPLEMENTARY INFORMATION: The meeting will be open to the public... advance by contacting Marian Norris via e-mail at mnorris@nasa.gov or by telephone at (202) 358-4452. July... SPACE ADMINISTRATION NASA Advisory Council; Science Committee; Planetary Protection...

  5. 75 FR 32229 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on ABWR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-07

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on ABWR The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on June 23-24, 2010, Room...

  6. 75 FR 57536 - Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on ABWR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION Advisory Committee on Reactor Safeguards (ACRS); Meeting of the ACRS Subcommittee on ABWR The ACRS Subcommittee on Advanced Boiling Water Reactor (ABWR) will hold a meeting on October 20, 2010, Room...

  7. 78 FR 17232 - Meeting of the Global Justice Information Sharing Initiative Federal Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... advance of the meeting. Purpose The GAC will act as the focal point for justice information systems... of Justice Programs Meeting of the Global Justice Information Sharing Initiative Federal Advisory... announcement of a meeting of the Global Justice Information Sharing Initiative (Global) Federal...

  8. Ownership & Authorship of Collaborative Academic Work. CAUT Intellectual Property Advisory. Number 2

    ERIC Educational Resources Information Center

    Canadian Association of University Teachers, 2008

    2008-01-01

    The purpose of this advisory is to assist academic staff members in avoiding conflict over ownership and authorship rights in collaborative academic work. When students, professors, librarians and other researchers work together in teams, they can create fundamental advances in knowledge. Unfortunately, these arrangements are also generating…

  9. Integrating Palliative Care Into the Care of Neurocritically Ill Patients: A Report From the Improving Palliative Care in the ICU Project Advisory Board and the Center to Advance Palliative Care.

    PubMed

    Frontera, Jennifer A; Curtis, J Randall; Nelson, Judith E; Campbell, Margaret; Gabriel, Michelle; Mosenthal, Anne C; Mulkerin, Colleen; Puntillo, Kathleen A; Ray, Daniel E; Bassett, Rick; Boss, Renee D; Lustbader, Dana R; Brasel, Karen J; Weiss, Stefanie P; Weissman, David E

    2015-09-01

    To describe unique features of neurocritical illness that are relevant to provision of high-quality palliative care; to discuss key prognostic aids and their limitations for neurocritical illnesses; to review challenges and strategies for establishing realistic goals of care for patients in the neuro-ICU; and to describe elements of best practice concerning symptom management, limitation of life support, and organ donation for the neurocritically ill. A search of PubMed and MEDLINE was conducted from inception through January 2015 for all English-language articles using the term "palliative care," "supportive care," "end-of-life care," "withdrawal of life-sustaining therapy," "limitation of life support," "prognosis," or "goals of care" together with "neurocritical care," "neurointensive care," "neurological," "stroke," "subarachnoid hemorrhage," "intracerebral hemorrhage," or "brain injury." We reviewed the existing literature on delivery of palliative care in the neurointensive care unit setting, focusing on challenges and strategies for establishing realistic and appropriate goals of care, symptom management, organ donation, and other considerations related to use and limitation of life-sustaining therapies for neurocritically ill patients. Based on review of these articles and the experiences of our interdisciplinary/interprofessional expert advisory board, this report was prepared to guide critical care staff, palliative care specialists, and others who practice in this setting. Most neurocritically ill patients and their families face the sudden onset of devastating cognitive and functional changes that challenge clinicians to provide patient-centered palliative care within a complex and often uncertain prognostic environment. Application of palliative care principles concerning symptom relief, goal setting, and family emotional support will provide clinicians a framework to address decision making at a time of crisis that enhances patient/family autonomy and

  10. Integrating palliative care in the surgical and trauma intensive care unit: a report from the Improving Palliative Care in the Intensive Care Unit (IPAL-ICU) Project Advisory Board and the Center to Advance Palliative Care.

    PubMed

    Mosenthal, Anne C; Weissman, David E; Curtis, J Randall; Hays, Ross M; Lustbader, Dana R; Mulkerin, Colleen; Puntillo, Kathleen A; Ray, Daniel E; Bassett, Rick; Boss, Renee D; Brasel, Karen J; Campbell, Margaret; Nelson, Judith E

    2012-04-01

    Although successful models for palliative care delivery and quality improvement in the intensive care unit have been described, their applicability in surgical intensive care unit settings has not been fully addressed. We undertook to define specific challenges, strategies, and solutions for integration of palliative care in the surgical intensive care unit. We searched the MEDLINE database from inception to May 2011 for all English language articles using the term "surgical palliative care" or the terms "surgical critical care," "surgical ICU," "surgeon," "trauma" or "transplant," and "palliative care" or "end-of- life care" and hand-searched our personal files for additional articles. Based on review of these articles and the experiences of our interdisciplinary expert Advisory Board, we prepared this report. We critically reviewed the existing literature on delivery of palliative care in the surgical intensive care unit setting focusing on challenges, strategies, models, and interventions to promote effective integration of palliative care for patients receiving surgical critical care and their families. Characteristics of patients with surgical disease and practices, attitudes, and interactions of different disciplines on the surgical critical care team present distinctive issues for intensive care unit palliative care integration and improvement. Physicians, nurses, and other team members in surgery, critical care and palliative care (if available) should be engaged collaboratively to identify challenges and develop strategies. "Consultative," "integrative," and combined models can be used to improve intensive care unit palliative care, although optimal use of trigger criteria for palliative care consultation has not yet been demonstrated. Important components of an improvement effort include attention to efficient work systems and practical tools and to attitudinal factors and "culture" in the unit and institution. Approaches that emphasize delivery of

  11. Missing from the table: role of the environmental public health community in governmental advisory commissions related to Marcellus Shale drilling.

    PubMed

    Goldstein, Bernard D; Kriesky, Jill; Pavliakova, Barbara

    2012-04-01

    The Marcellus Shale is a vast natural gas field underlying parts of Pennsylvania, New York, West Virginia, Virginia, and Maryland. Rapid development of this field has been enabled by advances in hydrofracking techniques that include injection of chemical and physical agents deep underground. Response to public concern about potential adverse environmental and health impacts has led to the formation of state and national advisory committees. We review the extent to which advisory committees formed in 2011 by President Obama and governors of the states of Maryland and Pennsylvania contain individuals with expertise pertinent to human environmental public health. We also analyze the extent to which human health issues are of concern to the public by reviewing presentations at the public meeting of the Secretary of Energy Advisory Board (SEAB) Natural Gas Subcommittee formed by the U.S. President's directive. At a public hearing held by the SEAB Natural Gas Subcommittee 62.7% of those not in favor of drilling mentioned health issues. Although public health is specified to be a concern in the executive orders forming these three advisory committees, we could identify no individuals with health expertise among the 52 members of the Pennsylvania Governor's Marcellus Shale Advisory Commission, the Maryland Marcellus Shale Safe Drilling Initiative Advisory Commission, or the SEAB Natural Gas Subcommittee. Despite recognition of the environmental public health concerns related to drilling in the Marcellus Shale, neither state nor national advisory committees selected to respond to these concerns contained recognizable environmental public health expertise.

  12. Weekly paclitaxel, capecitabine, and bevacizumab with maintenance capecitabine and bevacizumab as first-line therapy for triple-negative, metastatic, or locally advanced breast cancer: Results from the GINECO A-TaXel phase 2 study.

    PubMed

    Ferrero, Jean-Marc; Hardy-Bessard, Anne-Claire; Capitain, Olivier; Lortholary, Alain; Salles, Bruno; Follana, Philippe; Herve, Robert; Deblock, Mathilde; Dauba, Jérôme; Atlassi, Mustapha; Largillier, Rémy

    2016-10-15

    The current study was performed to determine the efficacy and safety of first-line combination therapy with bevacizumab, paclitaxel, and capecitabine for triple-negative, locally advanced/metastatic breast cancer (LA/MBC). Patients with measurable triple-negative LA/MBC who had received no prior chemotherapy for their disease received 4-weekly cycles of paclitaxel (80 mg/m(2) on days 1, 8, and 15 for up to 6 cycles) combined with capecitabine (800 mg/m(2) twice daily on days 1-5, 8-12, and 15-19) and bevacizumab (10 mg/kg on days 1 and 14) repeated every 4 weeks until disease progression or unacceptable toxicity occurred. The primary endpoint was the objective response rate; secondary endpoints were progression-free survival, duration of response, overall survival, and safety. Between April 2010 and March 2012, 62 eligible patients were enrolled. The median age of the patients was 57 years, 74% had received adjuvant chemotherapy, and 65% had visceral metastases. Patients received a median of 6 cycles (range, 1-45 cycles). The objective response rate was 77% (95% confidence interval [95% CI] 66%-88%), including complete response in 19% of patients. The median duration of response was 5.6 months (range, 1.3-27.6 months). The median progression-free survival was 7.6 months (95% CI, 6.3-9.0 months) and the median overall survival was 19.2 months (95% CI, 17.4-20.9 months). The most common grade ≥3 adverse events were hypertension (35% of patients) and neutropenia (23% of patients); 5% of patients experienced febrile neutropenia. Grade ≥2 hand-foot syndrome, alopecia, and nail toxicity each occurred in 40% of patients (adverse events were recorded before every cycle and graded according to Common Terminology Criteria for Adverse Events [version 4.0]). Treatment was interrupted because of toxicity in 22% of patients. A triplet regimen of paclitaxel, capecitabine, and bevacizumab followed by maintenance therapy with capecitabine and bevacizumab demonstrated high

  13. Epigenome Maintenance in Response to DNA Damage.

    PubMed

    Dabin, Juliette; Fortuny, Anna; Polo, Sophie E

    2016-06-02

    Organism viability relies on the stable maintenance of specific chromatin landscapes, established during development, that shape cell functions and identities by driving distinct gene expression programs. Yet epigenome maintenance is challenged during transcription, replication, and repair of DNA damage, all of which elicit dynamic changes in chromatin organization. Here, we review recent advances that have shed light on the specialized mechanisms contributing to the restoration of epigenome structure and function after DNA damage in the mammalian cell nucleus. By drawing a parallel with epigenome maintenance during replication, we explore emerging concepts and highlight open issues in this rapidly growing field. In particular, we present our current knowledge of molecular players that support the coordinated maintenance of genome and epigenome integrity in response to DNA damage, and we highlight how nuclear organization impacts genome stability. Finally, we discuss possible functional implications of epigenome plasticity in response to genotoxic stress. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Epigenome maintenance in response to DNA damage

    PubMed Central

    Dabin, Juliette; Fortuny, Anna; Polo, Sophie E.

    2017-01-01

    Summary Organism viability relies on the stable maintenance of specific chromatin landscapes, established during development, that shape cell functions and identities by driving distinct gene expression programs. Yet, epigenome maintenance is challenged during transcription, replication and repair of DNA damage, all of which elicit dynamic changes in chromatin organization. Here, we review recent advances that have shed light on the specialized mechanisms contributing to the restoration of epigenome structure and function after DNA damage in the mammalian cell nucleus. By drawing a parallel with epigenome maintenance during replication, we explore emerging concepts and highlight open issues in this rapidly growing field. In particular, we present our current knowledge of molecular players that support the coordinated maintenance of genome and epigenome integrity in response to DNA damage, and we highlight how nuclear organization impacts genome stability. Finally, we discuss possible functional implications of epigenome plasticity in response to genotoxic stress. PMID:27259203

  15. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    2001-01-01

    This annual report is based on the activities of the Aerospace Safety Advisory Panel in calendar year 2000. During this year, the construction of the International Space Station (ISS) moved into high gear. The launch of the Russian Service Module was followed by three Space Shuttle construction and logistics flights and the deployment of the Expedition One crew. Continuous habitation of the ISS has begun. To date, both the ISS and Space Shuttle programs have met or exceeded most of their flight objectives. In spite of the intensity of these efforts, it is clear that safety was always placed ahead of cost and schedule. This safety consciousness permitted the Panel to devote more of its efforts to examining the long-term picture. With ISS construction accelerating, demands on the Space Shuttle will increase. While Russian Soyuz and Progress spacecraft will make some flights, the Space Shuttle remains the primary vehicle to sustain the ISS and all other U.S. activities that require humans in space. Development of a next generation, human-rated vehicle has slowed due to a variety of technological problems and the absence of an approach that can accomplish the task significantly better than the Space Shuttle. Moreover, even if a viable design were currently available, the realities of funding and development cycles suggest that it would take many years to bring it to fruition. Thus, it is inescapable that for the foreseeable future the Space Shuttle will be the only human-rated vehicle available to the U.S. space program for support of the ISS and other missions requiring humans. Use of the Space Shuttle will extend well beyond current planning, and is likely to continue for the life of the ISS.

  16. Aerospace Safety Advisory Panel

    NASA Technical Reports Server (NTRS)

    1999-01-01

    This report covers the activities of the Aerospace Safety Advisory Panel (ASAP) for calendar year 1998-a year of sharp contrasts and significant successes at NASA. The year opened with the announcement of large workforce cutbacks. The slip in the schedule for launching the International Space Station (ISS) created a 5-month hiatus in Space Shuttle launches. This slack period ended with the successful and highly publicized launch of the STS-95 mission. As the year closed, ISS assembly began with the successful orbiting and joining of the Functional Cargo Block (FGB), Zarya, from Russia and the Unity Node from the United States. Throughout the year, the Panel maintained its scrutiny of NASAs safety processes. Of particular interest were the potential effects on safety of workforce reductions and the continued transition of functions to the Space Flight Operations Contractor. Attention was also given to the risk management plans of the Aero-Space Technology programs, including the X-33, X-34, and X-38. Overall, the Panel concluded that safety is well served for the present. The picture is not as clear for the future. Cutbacks have limited the depth of talent available. In many cases, technical specialties are "one deep." The extended hiring freeze has resulted in an older workforce that will inevitably suffer significant departures from retirements in the near future. The resulting "brain drain" could represent a future safety risk unless appropriate succession planning is started expeditiously. This and other topics are covered in the section addressing workforce. In the case of the Space Shuttle, beneficial and mandatory safety and operational upgrades are being delayed because of a lack of sufficient present funding. Likewise, the ISS has little flexibility to begin long lead-time items for upgrades or contingency planning.

  17. 78 FR 9917 - The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-12

    ... effective strategies for the implementation of best business practices to improve Federal Government... ADMINISTRATION The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting AGENCY: Office of Executive Councils, U.S. General Services Administration (GSA). ACTION: Meeting...

  18. 76 FR 65511 - The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... effective strategies for the implementation of best business practices to improve Federal Government... ADMINISTRATION The President's Management Advisory Board (PMAB); Notification of Upcoming Public Advisory Meeting AGENCY: Office of Executive Councils, U.S. General Services Administration (GSA). ACTION: Meeting...

  19. 75 FR 60484 - NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... SPACE ADMINISTRATION NASA Advisory Council; Science Committee; Earth Science Subcommittee; Applied Sciences Advisory Group Meeting AGENCY: National Aeronautics and Space Administration. ACTION: Notice of..., the National Aeronautics and Space Administration (NASA) announces a meeting of the Applied Science...

  20. Serving Boys through Readers' Advisory

    ERIC Educational Resources Information Center

    Sullivan, Michael

    2010-01-01

    Based on more than twenty years' experience working to get boys interested in reading, the author now offers his first readers' advisory volume. With an emphasis on nonfiction and the boy-friendly categories of genre fiction, the work offers a wealth of material including: (1) Suggestions for how to booktalk one-on-one as well as in large groups;…

  1. Advisory List of Computer Courseware.

    ERIC Educational Resources Information Center

    North Carolina State Dept. of Public Instruction, Raleigh. Div. of Educational Media.

    Computer courseware appropriate for instruction in grades K-12 is listed in two advisory lists. Entries, selected from materials submitted by producers which received favorable reviews by educators, are arranged in the following categories: arts education, communication skills, mathematics, science, utility (a quiz generator), word processing, and…

  2. Objectives of Youth Advisory Services.

    ERIC Educational Resources Information Center

    World Health Organization, Copenhagen (Denmark). Regional Office for Europe.

    Professionals concerned with youth advisory services from 10 countries met to exchange appropriate experiences and information on their role, organizations and operations, especially within the framework of other community services. Changes in their roles and objectives received special attention to determine possibilities for prevention and early…

  3. Serving Boys through Readers' Advisory

    ERIC Educational Resources Information Center

    Sullivan, Michael

    2010-01-01

    Based on more than twenty years' experience working to get boys interested in reading, the author now offers his first readers' advisory volume. With an emphasis on nonfiction and the boy-friendly categories of genre fiction, the work offers a wealth of material including: (1) Suggestions for how to booktalk one-on-one as well as in large groups;…

  4. Writing Reviews for Readers' Advisory

    ERIC Educational Resources Information Center

    Hooper, Brad

    2010-01-01

    Reviews are an important resource for readers' advisory and collection development. They are also a helpful promotional tool, introducing patrons to what is new on the shelf. This resource includes: (1) Tips for writing strong, relevant reviews; (2) Different ways reviews can be used to promote your library; and (3) A chapter by Joyce Saricks…

  5. Senior Adult Consumer Advisory Manual,

    ERIC Educational Resources Information Center

    Ater, E. Carolyn, Ed.

    This manual is intended for use by senior adult peer advisors (age 60 and over) engaged in helping relationships in providing consumer education to other senior adults. The advisory procedures are based on a problem solving approach which incorporates the development of a self-help concept. Chapter 1 provides information on consumer advising. It…

  6. Writing Reviews for Readers' Advisory

    ERIC Educational Resources Information Center

    Hooper, Brad

    2010-01-01

    Reviews are an important resource for readers' advisory and collection development. They are also a helpful promotional tool, introducing patrons to what is new on the shelf. This resource includes: (1) Tips for writing strong, relevant reviews; (2) Different ways reviews can be used to promote your library; and (3) A chapter by Joyce Saricks…

  7. Examining maintenance responsibilities.

    PubMed

    Lam, K C

    2001-06-01

    This paper has examined the important responsibilities of the two organisations involved in the provision of maintenance service for the vital building services in many of our highly serviced buildings. The issues raised could be put to beneficial use in both clients and maintenance providers. All in all, the clients should work closely with their maintenance providers. Engineering services in buildings will not perform satisfactorily and efficiently if both parties do not work together and understand the maintenance tasks based on a business partnering mode. Put forward is the view that the management of the activities involved in the operation and maintenance process is a "shared commitment/involvement" between the client and the maintenance provider. It is obvious that many factors can influence the continued effectiveness of a quality maintenance scheme set up by client and provider. Some of these factors are: Change in key personnel Updates in technology Amendments to engineering practice Implementation of legislative requirements Changes in operation by client or provider Change of use of building Passage of time These factors must be fully reviewed by both parties from time to time, and necessary actions taken. A cooperative team working relationship and improved communication should be fostered by the client and his provider for the best management of services maintenance. This arrangement will contribute to better building services systems with continuous improvement; improved value for clients and higher return for the maintenance provider.

  8. [Medical Equipment Maintenance Methods].

    PubMed

    Liu, Hongbin

    2015-09-01

    Due to the high technology and the complexity of medical equipment, as well as to the safety and effectiveness, it determines the high requirements of the medical equipment maintenance work. This paper introduces some basic methods of medical instrument maintenance, including fault tree analysis, node method and exclusive method which are the three important methods in the medical equipment maintenance, through using these three methods for the instruments that have circuit drawings, hardware breakdown maintenance can be done easily. And this paper introduces the processing methods of some special fault conditions, in order to reduce little detours in meeting the same problems. Learning is very important for stuff just engaged in this area.

  9. 62 FR 9455 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1997-03-03

    ... and Evolution of the Universe Advisory Subcommittee; Meeting AGENCY: National Aeronautics and Space... of the NASA Advisory Council, Space Science Advisory Committee, Structure and Evolution of the... following topics: --Status of Ongoing Missions --Structure and Evolution of Universe (SEU) Strategic...

  10. 61 FR 46667 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    1996-09-04

    ... From the Federal Register Online via the Government Publishing Office NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of the Universe Advisory Subcommittee; Meeting...

  11. Industrial Maintenance Technology. Technical Committee Report.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This Technical Committee Report prepared by industry representatives in Idaho lists the skills currently necessary for an employee in that state to obtain a job in industrial maintenance technology, retain a job once hired, and advance in that occupational field. (Task lists are grouped according to duty areas generally used in industry settings,…

  12. Industrial Maintenance Technology. Technical Committee Report.

    ERIC Educational Resources Information Center

    Idaho State Dept. of Education, Boise. Div. of Vocational Education.

    This Technical Committee Report prepared by industry representatives in Idaho lists the skills currently necessary for an employee in that state to obtain a job in industrial maintenance technology, retain a job once hired, and advance in that occupational field. (Task lists are grouped according to duty areas generally used in industry settings,…

  13. Impacts of traditional food consumption advisories: Compliance, changes in diet and loss of confidence in traditional foods

    PubMed Central

    2011-01-01

    Background Food consumption advisories are often posted when industrial activities are expected to affect the quality and availability of traditional foods used by First Nations. We were recently involved in a project and asked to summarize details regarding the impacts of traditional food consumption advisories with respect to compliance, broader changes in diet and loss of confidence in traditional foods by people. Methods Our review was not conducted as a formal systematic comprehensive review; rather, we focused on primary and grey literature presenting academic, health practitioner and First Nations viewpoints on the topic available from literature databases (i.e., PubMed, Web of KnowledgeSM) as well as the internet search engine Google. Some information came from personal communications. Results Our overview suggests that when communicated effectively and clearly, and when community members are involved in the process, consumption advisories can result in a decrease in contaminant load in people. On the other hand, consumption advisories can lead to cultural loss and have been linked to a certain amount of social, psychological, nutritional, economic and lifestyle disruption. In some cases, communities have decided to ignore consumption advisories opting to continue with traditional lifestyles believing that the benefits of doing so outweigh the risk of following advisories. Conclusions We identified that there are both positive and negative aspects to the issuance of traditional food consumption advisories. A number of variables need to be recognized during the development and implementation of advisories in order to ensure a balance between human health, maintenance of cultures and industrial activity. PMID:21651789

  14. 76 FR 49431 - Missouri River Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Missouri River Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Missouri River Resource Advisory Committee will meet in...

  15. 76 FR 44302 - Fresno County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-25

    ... Robbin Ekman, Fresno County Resource Advisory Committee Coordinator, c/ o Sierra National Forest, High... FURTHER INFORMATION CONTACT: Robbin Ekman, Fresno County Resource Advisory Committee Coordinator,...

  16. 16 CFR 16.4 - Advisory Committee Management Officer.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... designate the Executive Director as the Advisory Committee Management Officer who shall: (1) Exercise... Commission's advisory committees; (5) Maintain information on the nature, functions, and operations of...

  17. 76 FR 7531 - Yavapai County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Yavapai County Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. SUMMARY: The Yavapai County Resource Advisory Committee (RAC) will...

  18. 78 FR 53127 - Delta-Bienville Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    ...; ] DEPARTMENT OF AGRICULTURE Forest Service Delta-Bienville Resource Advisory Committee AGENCY: Forest Service, USDA. ACTION: Notice of meeting. Date change. SUMMARY: The Delta-Bienville Resource Advisory...

  19. 75 FR 59235 - Federal Advisory Committee; Army National Cemeteries Advisory Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ... of the Secretary Federal Advisory Committee; Army National Cemeteries Advisory Commission AGENCY... establishing the charter for the Army National Cemeteries Advisory Commission (hereafter referred to as ``the..., independent advice and recommendations on the Army National Cemeteries Program, including, but not limited...

  20. 75 FR 25212 - Federal Advisory Committee; Defense Audit Advisory Committee (DAAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... of the Secretary Federal Advisory Committee; Defense Audit Advisory Committee (DAAC) AGENCY: Under... that the Defense Audit Advisory Committee will meet on May 17, 2010. Subject to the availability of... include financial reporting processes, systems of internal controls, audit processes, and processes...

  1. 75 FR 22751 - Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing; Charter...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... members, who are eminent authorities in the fields of educational and psychological testing. Committee... of the Secretary Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing... notice that it is renewing the charter for the Defense Advisory Committee on Military Personnel...

  2. 75 FR 22754 - Federal Advisory Committee; Chief of Engineers Environmental Advisory Board; Charter Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... of the Secretary Federal Advisory Committee; Chief of Engineers Environmental Advisory Board; Charter... that it is renewing the charter for the Chief of Engineers Environmental Advisory Board (hereafter... the Chief of Engineers (U.S. Army Corps of Engineers) on matters relating to environmental issues...

  3. 78 FR 14299 - Notification of a Public Meeting of the Science Advisory Board Chemical Assessment Advisory...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-05

    ... AGENCY Notification of a Public Meeting of the Science Advisory Board Chemical Assessment Advisory... SAB Chemical Assessment Advisory Committee (CAAC) to receive a briefing about the Integrated Risk... for chemicals. DATES: The SAB CAAC meeting dates are Tuesday April 2, 2013 from 9 a.m. to 5:00...

  4. 78 FR 21349 - Defense Advisory Committee on Military Personnel Testing; Notice of Federal Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ... of the Secretary Defense Advisory Committee on Military Personnel Testing; Notice of Federal Advisory... Defense Advisory Committee on Military Personnel Testing will take place. DATES: Thursday, May 9, 2013... progress in developing computerized tests for military enlistment. Agenda: The agenda includes an overview...

  5. 75 FR 63823 - Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing... Defense announces that the Defense Advisory Committee on Military Personnel Testing will meet November 18...

  6. 75 FR 37410 - Federal Advisory Committee; Defense Advisory Committee on Military Personnel Testing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF DEFENSE Office of the Secretary Federal Advisory Committee; Defense Advisory Committee on Military Personnel...D announces that the Defense Advisory Committee on Military Personnel Testing will meet on July 22...

  7. 75 FR 81245 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DoD. ACTION: Notice. SUMMARY: Under the provisions of the... Defense Intelligence Agency Advisory Board and two of its subcommittees will meet on January 26 and 27...

  8. 75 FR 43493 - Office of the Secretary; Federal Advisory Committee; Defense Intelligence Agency Advisory Board...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... of the Secretary; Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DOD. ACTION: Meeting notice. SUMMARY: Under the provisions of... that Defense Intelligence Agency Advisory Board will meet on September 1 and 2, 2010. The meeting is...

  9. 75 FR 24926 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-06

    ... of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DoD. ACTION: Meeting notice. SUMMARY: Under the provisions of... that Defense Intelligence Agency Advisory Board, and its subcommittees, will meet on June 15 and 16...

  10. 76 FR 41220 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency, DoD. ACTION: Meeting notice. SUMMARY: Under the provisions of... that Defense Intelligence Agency Advisory Board and two of its subcommittees will meet on August 4 and...

  11. 77 FR 18797 - Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-28

    ... of the Secretary Federal Advisory Committee; Defense Intelligence Agency (DIA) Advisory Board; Closed... discussions of classified information relating to DIA's intelligence operations including its support to... intelligence operations. Agenda May 2, 2012 S 8:30 a.m Convene Advisory Board Meeting Mr. William Caniano...

  12. 76 FR 53671 - Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-29

    ... of the Secretary Federal Advisory Committee; Defense Intelligence Agency Advisory Board; Closed Meeting AGENCY: Defense Intelligence Agency (DIA), Department of Defense (DoD). ACTION: Meeting notice... Department of Defense announces that Defense Intelligence Agency Advisory Board and two of its subcommittees...

  13. 75 FR 22560 - Federal Advisory Committee; U.S. Air Force Scientific Advisory Board; Charter Renewal

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... of the Secretary Federal Advisory Committee; U.S. Air Force Scientific Advisory Board; Charter... that it is renewing the charter for the U.S. Air Force Scientific Advisory Board (hereafter referred to... of science and technology relating to the Air Force mission. The Board shall: a. Provide independent...

  14. 76 FR 40726 - Notification of Public Teleconferences of the Science Advisory Board Radiation Advisory Committee...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... AGENCY Notification of Public Teleconferences of the Science Advisory Board Radiation Advisory Committee Augmented With Additional Experts for a Consultation on Revisions to the Multi-Agency Radiation Survey and... teleconferences of the Radiation Advisory Committee (RAC) augmented for a consultation on the revisions to the...

  15. Integrating Palliative Care into the Care of Neurocritically Ill Patients: A Report from The IPAL-ICU (Improving Palliative Care in the Intensive Care Unit) Project Advisory Board and the Center to Advance Palliative Care

    PubMed Central

    Frontera, Jennifer A.; Curtis, J. Randall; Nelson, Judith E.; Campbell, Margaret; Gabriel, Michelle; Hays, Ross M.; Mosenthal, Anne C.; Mulkerin, Colleen; Puntillo, Kathleen A.; Ray, Daniel E.; Bassett, Rick; Boss, Renee D.; Lustbader, Dana R.; Brasel, Karen J.; Weiss, Stefanie P.; Weissman, David E.

    2015-01-01

    Objectives To describe unique features of neurocritical illness that are relevant to provision of high-quality palliative care; To discuss key prognostic aids and their limitations for neurocritical illnesses; To review challenges and strategies for establishing realistic goals of care for patients in the neuro-ICU; To describe elements of best practice concerning symptom management, limitation of life support, and organ donation for the neurocritically ill. Data Sources A search of Pubmed and MEDLINE was conducted from inception through January 2015 for all English-language articles using the term “palliative care,” “supportive care,” “end-of-life care,” “withdrawal of life-sustaining therapy,” “limitation of life support,” “prognosis,” or “goals of care” together with “neurocritical care,” “neurointensive care,” “neurological,” “stroke,” “subarachnoid hemorrhage,” “intracerebral hemorrhage,” or “brain injury.” Data Extraction and Synthesis We reviewed the existing literature on delivery of palliative care in the neurointensive care unit setting, focusing on challenges and strategies for establishing realistic and appropriate goals of care, symptom management, organ donation, and other considerations related to use and limitation of life-sustaining therapies for neurocritically ill patients. Based on review of these articles and the experiences of our interdisciplinary/interprofessional expert Advisory Board, this report was prepared to guide critical care staff, palliative care specialists, and others who practice in this setting. Conclusions Most neurocritically ill patients and their families face the sudden onset of devastating cognitive and functional changes that challenge clinicians to provide patient-centered palliative care within a complex and often uncertain prognostic environment. Application of palliative care principles concerning symptom relief, goal setting, and family emotional support, will

  16. Integrating palliative care in the surgical and trauma intensive care unit: A report from the Improving Palliative Care in the Intensive Care Unit (IPAL-ICU) Project Advisory Board and the Center to Advance Palliative Care

    PubMed Central

    Mosenthal, Anne C.; Weissman, David E.; Curtis, J. Randall; Hays, Ross M.; Lustbader, Dana R.; Mulkerin, Colleen; Puntillo, Kathleen A.; Ray, Daniel E.; Bassett, Rick; Boss, Renee D.; Brasel, Karen J.; Campbell, Margaret; Nelson, Judith E.

    2012-01-01

    Objective Although successful models for palliative care delivery and quality improvement in the intensive care unit have been described, their applicability in surgical intensive care unit settings has not been fully addressed. We undertook to define specific challenges, strategies, and solutions for integration of palliative care in the surgical intensive care unit. Data Sources We searched the MEDLINE database from inception to May 2011 for all English language articles using the term “surgical palliative care” or the terms “surgical critical care,” “surgical ICU,” “surgeon,” “trauma” or “transplant,” and “palliative care” or “end-of- life care” and hand-searched our personal files for additional articles. Based on review of these articles and the experiences of our interdisciplinary expert Advisory Board, we prepared this report. Data Extraction and Synthesis We critically reviewed the existing literature on delivery of palliative care in the surgical intensive care unit setting focusing on challenges, strategies, models, and interventions to promote effective integration of palliative care for patients receiving surgical critical care and their families. Conclusions Characteristics of patients with surgical disease and practices, attitudes, and interactions of different disciplines on the surgical critical care team present distinctive issues for intensive care unit palliative care integration and improvement. Physicians, nurses, and other team members in surgery, critical care and palliative care (if available) should be engaged collaboratively to identify challenges and develop strategies. “Consultative,” “integrative,” and combined models can be used to improve intensive care unit palliative care, although optimal use of trigger criteria for palliative care consultation has not yet been demonstrated. Important components of an improvement effort include attention to efficient work systems and practical tools and to

  17. 66 FR 56718 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2001-11-09

    ... and Evolution of the Universe Subcommittee (SEUS); Meeting AGENCY: National Aeronautics and Space... Advisory Council, Space Science Advisory Committee, Structure and Evolution of the Universe Subcommittee...

  18. 66 FR 9883 - NASA Advisory Council (NAC), Space Science Advisory Committee (SScAC), Structure and Evolution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2001-02-12

    ... and Evolution of the Universe Subcommittee AGENCY: National Aeronautics and Space Administration... Advisory Council, Space Science Advisory Committee, Structure and Evolution of the Universe Subcommittee...

  19. FE Fossum performs aRED In-Flight Maintenance

    NASA Image and Video Library

    2011-07-28

    ISS028-E-019392 (28 July 2011) --- NASA astronaut Mike Fossum, Expedition 28 flight engineer, performs in-flight maintenance on the advanced Resistive Exercise Device (aRED) in the Tranquility node of the International Space Station.

  20. A Human Relations Approach to Custodial and Maintenance Training.

    ERIC Educational Resources Information Center

    Parker, Woodrow M.; And Others

    1983-01-01

    Describes a training program for residence hall custodial and maintenance supervisors and staff which combines human relations and technical skills. The sessions dealt with communication skills, leadership strategies, performance appraisal, self-understanding, advancement, and fringe benefits. (JAC)